wget ftp://ftp.ebi.ac.uk/pub/databases/Pfam/releases/Pfam30.0/Pfam-A.hmm.gz
wget ftp://ftp.ebi.ac.uk/pub/databases/Pfam/releases/Pfam27.0/Pfam-B.hmm.gz
gzip -d Pfam-A.hmm.gz
gzip -d Pfam-B.hmm.gz
hmmpress Pfam-A.hmm
hmmpress Pfam-B.hmm