# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Trypsin PF00089.24 T072840_1 - 2.6e-48 164.6 0.0 3.7e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 T072840_1 - 7.5e-10 39.0 0.0 1.4e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 CUB domain Trypsin_2 PF13365.4 T072840_1 - 0.076 13.7 0.0 0.18 12.6 0.0 1.6 1 1 0 1 1 1 0 Trypsin-like peptidase domain CUB PF00431.18 T072840_2 - 1.6e-47 160.3 0.0 1.4e-27 96.1 0.0 2.3 2 0 0 2 2 2 2 CUB domain Trypsin PF00089.24 T072840_2 - 8.3e-44 149.9 0.0 1.3e-43 149.3 0.0 1.3 1 0 0 1 1 1 1 Trypsin FXa_inhibition PF14670.4 T072840_2 - 1.1e-09 38.3 6.4 1.1e-09 38.3 6.4 3.0 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 T072840_2 - 1.8e-05 24.7 6.2 1.8e-05 24.7 6.2 2.3 2 0 0 2 2 2 1 Calcium-binding EGF domain cEGF PF12662.5 T072840_2 - 0.00011 21.9 8.7 0.00013 21.7 3.4 2.9 2 0 0 2 2 2 1 Complement Clr-like EGF-like Sushi PF00084.18 T072840_2 - 0.00046 20.6 0.4 0.00046 20.6 0.4 2.7 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) EGF PF00008.25 T072840_2 - 0.006 16.7 6.9 0.034 14.3 6.9 2.3 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.5 T072840_2 - 0.11 13.1 9.7 0.024 15.2 4.1 3.1 2 0 0 2 2 2 0 Human growth factor-like EGF MFS_1 PF07690.14 T195700_2 - 5.2e-44 150.5 27.2 5.2e-44 150.5 27.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.22 T195700_2 - 4.1e-10 39.0 3.3 4.1e-10 39.0 3.3 1.8 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.5 T195700_2 - 0.13 11.0 18.3 12 4.5 18.5 2.2 1 1 0 1 1 1 0 MFS_1 like family SH3_2 PF07653.15 T080495_1 - 6e-13 48.1 1.2 5.5e-06 25.8 0.2 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 T080495_1 - 1.1e-12 47.2 0.8 2.5e-12 46.0 0.2 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 T080495_1 - 2.5e-12 46.3 3.2 3.8e-10 39.3 0.1 3.2 3 0 0 3 3 3 2 Variant SH3 domain C1_1 PF00130.20 T080495_1 - 1.1e-07 31.5 11.8 1.1e-07 31.5 11.8 2.3 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) STAC2_u1 PF16664.3 T080495_1 - 2.9e-07 30.9 0.1 7.2e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 B12D PF06522.9 T080495_2 - 1.5e-23 82.2 0.0 3.6e-23 81.0 0.0 1.7 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit SUZ PF12752.5 T080495_3 - 3.7e-10 40.3 4.9 3.7e-10 40.3 4.9 3.0 2 0 0 2 2 2 1 SUZ domain R3H PF01424.20 T080495_3 - 4.3e-10 39.3 0.0 7.9e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 R3H domain PH PF00169.27 T000198_1 - 4.9e-05 23.7 0.0 0.1 12.9 0.0 2.3 2 0 0 2 2 2 2 PH domain Kelch_1 PF01344.23 T000198_2 - 1.8e-71 235.4 18.4 1.6e-14 53.1 0.3 7.1 6 0 0 6 6 6 6 Kelch motif BACK PF07707.13 T000198_2 - 7.9e-37 125.4 0.1 1.2e-36 124.8 0.1 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_6 PF13964.4 T000198_2 - 1.7e-36 123.2 7.4 3.3e-06 27.1 0.1 7.1 2 1 5 7 7 7 6 Kelch motif BTB PF00651.29 T000198_2 - 2.9e-31 107.8 0.9 3.5e-31 107.6 0.2 1.5 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.4 T000198_2 - 1.3e-19 69.8 8.6 0.004 17.0 0.0 7.4 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_3 PF13415.4 T000198_2 - 9.8e-19 67.0 27.9 0.00016 21.7 0.0 8.3 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.13 T000198_2 - 2.4e-18 65.2 11.8 0.00062 19.5 0.1 6.8 7 0 0 7 7 7 5 Kelch motif Kelch_5 PF13854.4 T000198_2 - 0.00085 19.1 7.0 8.2 6.4 0.0 4.9 5 0 0 5 5 5 1 Kelch motif DUF4770 PF15994.3 T000198_2 - 3.8 7.6 4.6 6.6 6.8 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) EF-hand_1 PF00036.30 T062119_2 - 6.7e-25 84.6 5.3 4e-08 32.1 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 T062119_2 - 3e-20 72.3 2.8 2.5e-13 50.2 0.5 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 T062119_2 - 4.7e-20 71.0 4.5 5.7e-08 32.3 0.1 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.4 T062119_2 - 5.4e-19 66.3 4.1 1.2e-07 31.0 0.0 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.4 T062119_2 - 5.1e-17 60.4 7.4 1.4e-07 30.6 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.4 T062119_2 - 0.00089 19.4 0.1 1.3 9.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.7 T062119_2 - 0.14 12.3 0.0 11 6.2 0.0 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF3349 PF11829.6 T062119_2 - 0.17 12.5 0.0 24 5.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) ODAM PF15424.4 T266123_3 - 5.6e-133 442.3 23.1 7.5e-133 441.9 23.1 1.1 1 0 0 1 1 1 1 Odontogenic ameloblast-associated family Glyco_transf_54 PF04666.11 T295015_1 - 4.8e-134 445.6 0.0 6.5e-134 445.2 0.0 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF1725 PF08333.9 T344502_3 - 0.76 9.4 5.0 0.1 12.2 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1725) Trypsin PF00089.24 T265750_3 - 2.9e-64 216.8 0.2 4.3e-64 216.2 0.2 1.3 1 0 0 1 1 1 1 Trypsin SEA PF01390.18 T265750_3 - 2e-25 89.0 0.8 3.2e-25 88.3 0.8 1.3 1 0 0 1 1 1 1 SEA domain Trypsin_2 PF13365.4 T265750_3 - 0.00052 20.8 0.0 0.0011 19.7 0.0 1.5 2 0 0 2 2 2 1 Trypsin-like peptidase domain DUF1986 PF09342.9 T265750_3 - 0.007 16.6 0.1 0.014 15.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) A_deamin PF02137.16 T035381_2 - 4e-107 358.3 0.0 5.4e-107 357.9 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 T035381_2 - 2.4e-21 76.1 0.0 2.2e-11 44.2 0.0 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif Peptidase_S68 PF10461.7 T035381_2 - 0.17 12.0 2.6 0.7 10.0 2.6 2.1 1 0 0 1 1 1 0 Peptidase S68 HECT PF00632.23 T102503_3 - 3.3e-73 246.7 0.0 6.9e-73 245.7 0.0 1.5 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Sad1_UNC PF07738.11 T102503_3 - 3.8e-24 85.1 0.0 6.8e-24 84.3 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal MIB_HERC2 PF06701.11 T102503_3 - 2.1e-23 82.2 2.6 4.9e-23 81.0 2.6 1.7 1 0 0 1 1 1 1 Mib_herc2 Ank_2 PF12796.5 T102503_3 - 4.4e-18 65.5 0.0 6.3e-10 39.4 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T102503_3 - 5.1e-10 39.3 0.0 5.3e-07 29.7 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 T102503_3 - 5.8e-08 33.0 0.0 5.9e-06 26.6 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 T102503_3 - 9.4e-08 31.6 0.0 0.098 13.1 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.28 T102503_3 - 1.7e-07 31.2 0.0 0.00053 20.2 0.0 4.1 4 0 0 4 4 3 1 Ankyrin repeat F5_F8_type_C PF00754.23 T102503_3 - 1.7e-05 24.8 0.1 4e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 F5/8 type C domain Arm PF00514.21 T102503_3 - 1.9 8.5 5.5 34 4.5 0.0 4.6 6 0 0 6 6 4 0 Armadillo/beta-catenin-like repeat Cwf_Cwc_15 PF04889.10 T102503_3 - 3 7.4 11.0 0.053 13.1 1.5 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SF1-HH PF16275.3 T060857_1 - 1.6e-12 47.6 0.0 2.7e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain SF1-HH PF16275.3 T060857_2 - 2.1e-22 79.5 0.6 2.1e-22 79.5 0.6 1.6 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.27 T060857_2 - 6e-07 29.1 0.3 1e-06 28.3 0.3 1.4 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.21 T060857_2 - 0.00031 20.5 1.6 0.00084 19.2 1.6 1.7 1 0 0 1 1 1 1 Zinc knuckle AbLIM_anchor PF16182.3 T340178_2 - 2.3e-78 264.5 28.5 4.5e-56 191.1 9.9 2.8 2 1 1 3 3 3 2 Putative adherens-junction anchoring region of AbLIM FGF PF00167.16 T340178_2 - 6.3e-39 132.8 0.1 2.1e-38 131.1 0.7 1.6 2 0 0 2 2 2 1 Fibroblast growth factor Nucleoplasmin PF03066.13 T340178_2 - 5.1e-34 116.7 0.0 8.7e-34 115.9 0.0 1.4 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain VHP PF02209.17 T340178_2 - 5.2e-14 51.9 0.8 1.2e-13 50.7 0.8 1.7 1 0 0 1 1 1 1 Villin headpiece domain YL1 PF05764.11 T340178_2 - 0.0021 18.1 6.1 0.0021 18.1 6.1 2.4 2 0 0 2 2 2 1 YL1 nuclear protein MPP6 PF10175.7 T340178_2 - 3.6 8.0 10.8 8.9 6.7 3.7 2.5 2 0 0 2 2 2 0 M-phase phosphoprotein 6 Myc_target_1 PF15179.4 T313780_3 - 5.2e-75 251.5 4.6 7.2e-75 251.0 4.6 1.2 1 0 0 1 1 1 1 Myc target protein 1 DAGK_acc PF00609.17 T256402_1 - 1.4e-56 191.1 0.0 2.1e-56 190.6 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 T256402_1 - 6.3e-16 58.0 0.0 1.1e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DAG_kinase_N PF14513.4 T256402_3 - 3e-52 177.1 0.1 5.2e-52 176.3 0.1 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus C1_1 PF00130.20 T256402_3 - 6.5e-13 48.2 33.6 5.5e-09 35.7 11.2 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.30 T256402_3 - 1.5e-06 27.2 1.0 0.023 14.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 T256402_3 - 2.2e-06 27.9 0.3 4.1e-06 27.0 0.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T256402_3 - 0.0011 18.6 0.1 0.68 9.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 T256402_3 - 0.06 12.8 0.4 0.29 10.6 0.0 2.1 2 0 0 2 2 2 0 EF hand HECT PF00632.23 T348775_2 - 2.4e-65 220.9 0.0 3.9e-65 220.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) E3_UbLigase_EDD PF11547.6 T348775_2 - 9.1e-31 105.2 4.1 2.1e-30 104.1 4.1 1.6 1 0 0 1 1 1 1 E3 ubiquitin ligase EDD PABP PF00658.16 T348775_2 - 5.1e-20 71.3 0.0 1.1e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain 6PGD PF00393.17 T002895_1 - 3.8e-129 430.0 0.0 4.9e-129 429.7 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.13 T002895_1 - 1.7e-47 161.4 0.0 2.4e-47 160.9 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Kinesin PF00225.21 T002895_3 - 4.7e-115 383.9 0.6 6.3e-115 383.5 0.6 1.2 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.3 T002895_3 - 4.3e-78 261.5 4.1 3.4e-75 252.0 4.1 2.6 1 1 0 1 1 1 1 Kinesin-associated DUF3694 PF12473.6 T002895_3 - 1.6e-37 129.4 0.0 2.8e-37 128.6 0.0 1.4 1 0 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.3 T002895_3 - 1.6e-23 83.2 0.2 3.8e-23 81.9 0.2 1.7 1 0 0 1 1 1 1 Microtubule binding PH PF00169.27 T002895_3 - 4.9e-13 49.4 0.1 1.1e-10 41.8 0.0 3.1 2 0 0 2 2 2 1 PH domain KIF1B PF12423.6 T002895_3 - 1.3e-12 47.9 13.0 3e-11 43.5 0.1 3.0 3 0 0 3 3 3 2 Kinesin protein 1B FHA PF00498.24 T002895_3 - 4.2e-07 30.1 0.1 1e-06 28.8 0.1 1.7 1 0 0 1 1 1 1 FHA domain Transglut_C PF00927.20 T115428_2 - 6.8e-50 167.5 0.1 4.2e-26 91.0 0.1 2.3 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.17 T115428_2 - 2.3e-18 66.5 0.5 4.3e-18 65.7 0.5 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily ENOD40 PF08247.9 T340434_1 - 5.8 7.0 9.5 24 5.1 1.4 3.2 2 0 0 2 2 2 0 ENOD40 protein ENOD40 PF08247.9 T340434_2 - 4.8 7.3 9.5 24 5.1 1.4 3.3 2 0 0 2 2 2 0 ENOD40 protein C2 PF00168.28 T059794_3 - 4.7e-52 174.4 1.8 8.5e-26 90.1 0.1 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.4 T059794_3 - 0.1 12.0 0.0 0.28 10.6 0.0 1.6 2 0 0 2 2 2 0 CEP76 C2 domain IMD PF08397.9 T350807_1 - 7.4e-106 352.3 4.2 9.7e-106 351.9 4.2 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain WH2 PF02205.18 T350807_1 - 8.1e-07 28.6 0.1 1.7e-06 27.5 0.1 1.6 1 0 0 1 1 1 1 WH2 motif OmpH PF03938.12 T350807_1 - 9.8 6.0 9.9 18 5.2 9.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Mito_carr PF00153.25 T380005_2 - 1.3e-37 127.4 0.2 6.5e-20 70.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.25 T380005_3 - 1.1e-20 73.2 0.1 1.8e-20 72.5 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial carrier protein Cadherin PF00028.15 T065742_3 - 0 1567.8 69.2 7.6e-22 77.4 0.0 34.6 35 0 0 35 35 35 33 Cadherin domain Cadherin_2 PF08266.10 T065742_3 - 3.3e-24 84.4 0.3 4.1 7.1 0.0 17.2 18 0 0 18 18 18 4 Cadherin-like Laminin_G_2 PF02210.22 T065742_3 - 3.3e-24 85.7 0.3 4.1e-23 82.2 0.0 3.0 3 0 0 3 3 3 1 Laminin G domain Laminin_G_1 PF00054.21 T065742_3 - 1.8e-17 63.6 0.0 5.1e-17 62.2 0.0 1.9 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.25 T065742_3 - 2.2e-10 40.5 56.8 0.00043 20.4 8.9 5.2 4 0 0 4 4 4 3 EGF-like domain Cadherin_3 PF16184.3 T065742_3 - 4.3e-10 39.5 69.6 0.057 13.3 0.4 20.4 24 0 0 24 24 24 4 Cadherin-like Cadherin_pro PF08758.9 T065742_3 - 2.4e-07 30.7 0.1 5.7 7.0 0.0 8.9 12 0 0 12 12 12 2 Cadherin prodomain like EGF_CA PF07645.13 T065742_3 - 0.00011 22.2 11.0 0.00011 22.2 11.0 4.6 3 1 1 4 4 4 1 Calcium-binding EGF domain hEGF PF12661.5 T065742_3 - 0.00021 21.7 46.9 0.016 15.7 8.2 5.2 4 0 0 4 4 4 3 Human growth factor-like EGF OFCC1 PF15680.3 T297086_2 - 5.7e-56 187.6 2.8 1.1e-55 186.7 2.8 1.5 1 0 0 1 1 1 1 Orofacial cleft 1 candidate gene 1 protein WD40 PF00400.30 T168957_1 - 2.3e-13 50.2 12.1 0.0037 17.9 0.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T168957_1 - 0.00029 21.0 0.0 0.32 11.2 0.0 3.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 T168957_3 - 0.0075 17.0 0.2 0.11 13.3 0.1 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat Forkhead PF00250.16 T144544_1 - 1.7e-31 108.2 0.2 2.8e-31 107.5 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain CCDC73 PF15818.3 T056793_2 - 7.4e-07 27.4 1.1 9.8e-07 27.0 1.1 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 73 family Pkinase_Tyr PF07714.15 T342300_1 - 7.1e-104 346.6 0.0 1.2e-103 345.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T342300_1 - 1.7e-45 155.3 0.0 2.7e-45 154.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 T342300_1 - 1.8e-28 98.3 0.0 1.5e-13 50.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 T342300_1 - 2.3e-24 85.7 0.1 2.1e-11 44.1 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 T342300_1 - 1e-18 67.1 0.0 1.4e-08 34.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 T342300_1 - 2.9e-18 65.9 0.2 1.2e-09 38.3 0.1 3.1 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 T342300_1 - 2.3e-09 37.3 0.1 0.00049 20.1 0.0 3.4 3 1 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 T342300_1 - 0.0085 16.0 0.0 0.76 9.8 0.0 2.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain DUF4611 PF15387.4 T342300_1 - 0.24 11.5 1.3 0.46 10.6 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) BEN PF10523.7 T371995_1 - 2e-15 56.6 0.2 6.5e-09 35.8 0.0 2.5 2 0 0 2 2 2 2 BEN domain zf-H2C2_2 PF13465.4 T176810_1 - 4.4e-57 188.0 86.7 1.1e-08 35.0 0.3 12.7 13 0 0 13 13 13 8 Zinc-finger double domain zf-C2H2 PF00096.24 T176810_1 - 5.1e-34 114.7 78.9 5.4e-06 26.4 2.0 12.1 11 0 0 11 11 11 8 Zinc finger, C2H2 type KRAB PF01352.25 T176810_1 - 8.4e-21 73.2 0.4 1.6e-20 72.3 0.4 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T176810_1 - 4.1e-07 30.1 85.1 0.028 15.1 1.7 11.8 11 0 0 11 11 11 6 C2H2-type zinc finger zf-met PF12874.5 T176810_1 - 5.2e-05 23.3 59.0 0.0027 17.9 1.9 8.4 9 0 0 9 9 9 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T176810_1 - 0.0001 22.4 56.5 0.0017 18.5 0.1 10.4 11 0 0 11 11 11 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T176810_1 - 0.12 12.3 38.6 0.17 11.9 2.6 5.7 5 1 0 5 5 5 0 Zinc ribbon domain BolA PF01722.16 T176810_1 - 1.1 9.4 18.6 13 6.0 0.1 5.0 3 1 1 5 5 5 0 BolA-like protein zf-C2H2_6 PF13912.4 T176810_1 - 9 6.3 42.1 4 7.4 0.9 8.4 8 0 0 8 8 8 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T176810_2 - 4e-74 241.8 104.8 1.4e-07 31.5 0.6 15.5 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 T176810_2 - 3.5e-46 153.0 97.9 1.2e-05 25.3 0.2 14.8 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T176810_2 - 6.9e-20 69.9 91.4 0.026 15.2 0.3 14.5 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 T176810_2 - 9.9e-19 66.6 0.6 1.8e-18 65.8 0.6 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 T176810_2 - 0.00011 22.2 46.2 1.5 9.1 0.1 11.1 11 0 0 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T176810_2 - 4.2 7.3 72.6 0.099 12.5 0.5 12.6 13 0 0 13 13 13 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T176810_2 - 7.6 6.6 73.7 0.53 10.3 3.3 8.4 4 1 7 11 11 11 0 Zinc ribbon domain BolA PF01722.16 T176810_2 - 9.8 6.4 12.7 15 5.8 0.4 4.0 3 0 0 3 3 3 0 BolA-like protein zf-C2H2 PF00096.24 T072606_1 - 5.2e-29 98.9 80.1 0.00022 21.4 3.3 9.4 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T072606_1 - 4.7e-28 96.2 71.1 3.4e-05 23.9 0.3 9.3 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 T072606_1 - 1.5e-13 50.1 76.8 0.0068 17.0 1.0 9.7 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2HC_2 PF13913.4 T072606_1 - 4.7e-05 23.1 17.1 0.025 14.4 0.4 5.4 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 T072606_1 - 0.00085 19.4 45.9 0.038 14.2 0.5 7.6 6 1 1 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T072606_1 - 0.0013 18.5 0.1 0.0013 18.5 0.1 8.5 8 0 0 8 8 8 3 C2H2-type zinc finger TFIIA PF03153.11 T072606_1 - 0.042 13.7 28.9 0.069 13.0 28.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit API5 PF05918.9 T072606_1 - 0.15 10.7 9.5 0.29 9.8 9.5 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) TerY_C PF15616.4 T072606_1 - 4 7.4 9.1 12 5.9 0.3 3.5 2 1 1 3 3 3 0 TerY-C metal binding domain DUF4407 PF14362.4 T072606_1 - 7.3 5.7 11.7 11 5.1 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AJAP1_PANP_C PF15298.4 T072606_3 - 7.4e-07 29.4 0.0 1.8e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 AJAP1/PANP C-terminus KH_1 PF00013.27 T228130_1 - 2.1e-53 177.9 13.9 2.7e-18 65.4 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 T228130_1 - 4.7e-13 48.6 6.7 0.00012 21.7 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 T228130_1 - 1.8e-06 27.6 1.1 0.029 14.1 0.3 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 T228130_1 - 0.0014 18.5 7.9 2 8.4 0.2 3.3 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.3 T228130_1 - 0.028 14.3 0.0 0.21 11.5 0.0 2.3 3 0 0 3 3 3 0 KH-like RNA-binding domain ACTH_domain PF00976.16 T228130_3 - 1.9 8.4 18.9 11 5.9 1.6 4.0 3 0 0 3 3 3 0 Corticotropin ACTH domain DUF3456 PF11938.6 T336694_2 - 2.7e-20 73.3 0.1 4.8e-20 72.5 0.1 1.3 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP I-set PF07679.14 T274205_1 - 2.2e-97 319.2 0.0 2.7e-22 78.5 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 T274205_1 - 6e-64 212.5 0.1 3.1e-13 50.0 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 T274205_1 - 1.2e-44 150.2 0.9 6.4e-10 38.9 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 T274205_1 - 5.3e-43 145.1 0.3 5.8e-10 39.2 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.15 T274205_1 - 7.6e-19 67.8 0.3 0.0011 18.9 0.0 6.9 5 1 0 5 5 5 4 Immunoglobulin V-set domain C2-set_2 PF08205.10 T274205_1 - 1e-13 51.0 0.3 0.064 13.2 0.0 4.9 5 0 0 5 5 5 4 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.6 T274205_1 - 0.005 16.9 0.0 0.56 10.3 0.0 3.6 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 DAGK_cat PF00781.22 T235543_3 - 3.9e-29 100.7 0.0 6.1e-29 100.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain ETRAMP PF09716.8 T260298_1 - 1.6 8.7 5.4 13 5.8 0.5 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Homeobox PF00046.27 T260298_3 - 3.5e-20 71.4 4.6 7.5e-20 70.4 4.6 1.6 1 0 0 1 1 1 1 Homeobox domain Pkinase PF00069.23 T101795_1 - 2.9e-37 128.3 0.0 4.1e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T101795_1 - 1.5e-31 109.5 0.0 2.1e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase AC_N PF16214.3 T101795_1 - 1.2e-17 64.1 0.0 1.9e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Adenylyl cyclase N-terminal extracellular and transmembrane region Guanylate_cyc PF00211.18 T101795_1 - 2.7e-09 36.8 0.0 4e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.21 T101795_1 - 0.0062 16.4 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Guanylate_cyc PF00211.18 T101795_2 - 5.4e-52 175.9 0.0 7.8e-52 175.4 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Guanylate_cyc PF00211.18 T101795_3 - 1.3e-39 135.6 0.1 2.5e-35 121.6 0.0 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.12 T101795_3 - 3e-31 107.9 0.2 5.3e-31 107.1 0.2 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) RHIM PF12721.5 T101795_3 - 2.2e-06 27.9 2.5 2.2e-06 27.9 2.5 3.4 3 0 0 3 3 3 1 RIP homotypic interaction motif Pkinase_Tyr PF07714.15 T101795_3 - 0.0039 16.4 0.0 0.01 15.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase CD52 PF15116.4 T101795_3 - 0.41 10.6 2.1 0.69 9.8 0.0 2.4 2 0 0 2 2 2 0 CAMPATH-1 antigen WWE PF02825.18 T327030_3 - 7.9e-32 109.5 0.6 2.1e-15 56.9 0.0 2.4 2 0 0 2 2 2 2 WWE domain zf-C3HC4 PF00097.23 T327030_3 - 0.00069 19.3 4.0 0.00069 19.3 4.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 T327030_3 - 0.003 17.7 2.3 0.008 16.3 2.3 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 T327030_3 - 1.1 8.9 6.8 0.61 9.7 0.2 2.9 3 0 0 3 3 3 0 RING-like zinc finger Ank_2 PF12796.5 T266368_1 - 4.5e-150 488.5 38.4 1.5e-19 70.2 0.9 12.3 3 3 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T266368_1 - 3.5e-125 406.8 14.4 5.5e-12 45.8 0.0 16.4 7 4 9 17 17 17 17 Ankyrin repeats (many copies) Ank PF00023.28 T266368_1 - 1.7e-111 360.1 56.1 6e-08 32.7 0.0 24.9 25 0 0 25 25 25 21 Ankyrin repeat Ank_3 PF13606.4 T266368_1 - 8.4e-102 320.6 32.6 7.9e-05 22.6 0.0 25.6 25 0 0 25 25 25 22 Ankyrin repeat Ank_5 PF13857.4 T266368_1 - 1e-98 321.5 49.9 3.4e-10 39.9 0.0 21.1 7 4 14 21 21 21 21 Ankyrin repeats (many copies) KH_1 PF00013.27 T266368_1 - 1.6e-15 56.5 2.4 4e-15 55.2 2.4 1.8 1 0 0 1 1 1 1 KH domain KH_4 PF13083.4 T266368_1 - 0.039 13.7 0.0 0.18 11.6 0.0 2.2 1 0 0 1 1 1 0 KH domain C2-set_2 PF08205.10 T177019_2 - 1.7e-20 72.8 0.8 4.4e-20 71.4 0.2 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 T177019_2 - 1.7e-11 44.5 2.4 0.0041 17.6 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T177019_2 - 2.9e-10 40.0 0.0 0.01 15.8 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T177019_2 - 1.4e-09 37.9 0.0 9.4e-09 35.3 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T177019_2 - 0.00059 20.0 0.6 2.1 8.6 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 T177019_2 - 0.00095 19.1 0.0 1.2 9.1 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.15 T177019_3 - 1.2e-06 28.5 0.0 2.2e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain DSPc PF00782.18 T044247_1 - 0.00022 20.9 0.0 0.00031 20.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DSPc PF00782.18 T044247_2 - 2.6e-25 88.6 0.0 3.5e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 T044247_2 - 0.0011 18.5 0.1 0.0016 17.9 0.1 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RhoGAP PF00620.25 T290385_1 - 1e-35 122.7 0.0 1.9e-35 121.8 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 T290385_1 - 7.6e-34 116.3 0.0 5.3e-12 46.0 0.0 5.4 5 0 0 5 5 5 5 PH domain ArfGap PF01412.16 T290385_1 - 8.4e-30 103.1 0.0 1.6e-29 102.2 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf SH3_9 PF14604.4 T290385_1 - 2e-20 72.2 1.4 1.9e-09 37.1 0.1 2.8 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.21 T290385_1 - 7.4e-17 61.3 2.0 2.3e-16 59.7 0.1 2.6 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.26 T290385_1 - 2.7e-16 58.8 0.3 3.7e-08 32.7 0.2 2.6 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.15 T290385_1 - 4.5e-16 58.2 0.1 1.7e-07 30.7 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain RA PF00788.21 T290385_1 - 1.2e-11 44.9 0.0 2.7e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_2 PF07647.15 T290385_1 - 1.8e-11 43.8 0.1 5.1e-11 42.4 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 T290385_1 - 1.1e-09 38.4 0.0 5.1e-09 36.3 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH_8 PF15409.4 T290385_1 - 2.7e-06 27.4 0.0 0.0001 22.3 0.0 2.9 3 0 0 3 3 3 1 Pleckstrin homology domain PH_3 PF14593.4 T290385_1 - 1.1e-05 25.3 0.0 0.002 18.1 0.0 2.6 2 0 0 2 2 2 1 PH domain PH_6 PF15406.4 T290385_1 - 5.6e-05 23.3 0.0 0.0002 21.5 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain hSH3 PF14603.4 T290385_1 - 0.0039 17.6 0.0 0.0085 16.5 0.0 1.5 1 0 0 1 1 1 1 Helically-extended SH3 domain PH_2 PF08458.8 T290385_1 - 0.0078 16.4 0.6 0.69 10.2 0.1 2.9 3 0 0 3 3 3 1 Plant pleckstrin homology-like region SH3_3 PF08239.9 T290385_1 - 0.029 14.5 0.3 0.06 13.5 0.3 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain Tetraspannin PF00335.18 T072365_1 - 2.3e-43 148.3 10.5 2.3e-43 148.3 10.5 2.5 3 0 0 3 3 3 1 Tetraspanin family Glyco_hydro_47 PF01532.18 T237157_1 - 6.6e-112 374.6 0.0 9.8e-112 374.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_47 PF01532.18 T237157_2 - 0.047 12.4 0.0 0.06 12.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 47 GDNF PF02351.14 T305509_3 - 8.8e-19 68.1 55.9 3.6e-10 40.5 11.7 3.4 3 0 0 3 3 3 2 GDNF/GAS1 domain zf-H2C2_2 PF13465.4 T173334_1 - 9.4e-74 240.7 85.0 1.1e-08 35.0 0.6 14.8 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 T173334_1 - 1.1e-41 138.8 100.0 3e-05 24.1 0.3 13.7 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T173334_1 - 2.5e-23 80.6 90.8 0.045 14.4 0.3 13.7 13 0 0 13 13 13 10 C2H2-type zinc finger KRAB PF01352.25 T173334_1 - 4.1e-23 80.7 0.3 7.5e-23 79.8 0.3 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T173334_1 - 3.1e-15 55.5 74.9 0.0011 18.7 0.5 13.0 13 0 0 13 13 13 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T173334_1 - 9.2e-05 22.4 48.4 0.066 13.2 3.2 7.9 2 2 7 9 9 9 6 Zinc ribbon domain FYVE PF01363.19 T173334_1 - 0.065 13.3 52.8 0.019 15.0 3.2 5.4 2 2 2 4 4 4 0 FYVE zinc finger XPA_N PF01286.16 T173334_1 - 2 8.4 42.9 15 5.6 0.0 10.4 11 0 0 11 11 11 0 XPA protein N-terminal zf-C2H2_jaz PF12171.6 T173334_1 - 3.3 8.0 60.2 0.58 10.4 0.4 10.5 13 0 0 13 13 13 0 Zinc-finger double-stranded RNA-binding YIF1 PF03878.13 T061580_2 - 3.7e-53 180.4 0.6 3.6e-43 147.7 0.2 2.1 1 1 1 2 2 2 2 YIF1 Yip1 PF04893.15 T061580_2 - 0.0022 17.6 2.5 0.0049 16.5 2.5 1.5 1 0 0 1 1 1 1 Yip1 domain Nramp PF01566.16 T207669_1 - 3.7e-31 108.3 0.0 5e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein NIF PF03031.16 T207669_2 - 2.9e-50 170.0 0.0 4e-50 169.5 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Nramp PF01566.16 T207669_2 - 3e-40 138.2 3.9 4e-40 137.8 3.9 1.2 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Nramp PF01566.16 T207669_3 - 1.8e-30 106.0 0.3 2.6e-30 105.5 0.3 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein CAMSAP_CKK PF08683.9 T368952_2 - 2.2e-54 182.6 0.0 3.4e-54 182.0 0.0 1.3 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH PF11971.6 T368952_2 - 3.4e-34 116.4 0.2 6.6e-34 115.5 0.2 1.5 1 0 0 1 1 1 1 CAMSAP CH domain CAMSAP_CC1 PF17095.3 T368952_2 - 1.3e-25 88.9 3.5 1.3e-25 88.9 3.5 2.6 2 1 0 2 2 2 1 Spectrin-binding region of Ca2+-Calmodulin zf-C2H2 PF00096.24 T132268_2 - 4.1e-31 105.5 78.0 2.1e-05 24.6 0.2 10.6 11 0 0 11 11 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T132268_2 - 1.5e-26 90.6 88.7 0.00014 22.3 0.4 11.4 12 0 0 12 12 10 9 C2H2-type zinc finger zf-met PF12874.5 T132268_2 - 5.6e-26 90.0 53.1 0.00042 20.5 0.6 9.8 9 0 0 9 9 9 8 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T132268_2 - 5e-24 83.9 39.1 0.00025 21.1 1.4 9.6 9 0 0 9 9 9 7 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.4 T132268_2 - 5.7e-22 77.0 72.5 5.3e-07 29.7 1.0 11.9 13 0 0 13 13 12 5 Zinc-finger double domain zf-C2H2_6 PF13912.4 T132268_2 - 4.2e-07 29.6 59.7 0.24 11.3 1.8 10.2 10 0 0 10 10 10 7 C2H2-type zinc finger zf-Di19 PF05605.10 T132268_2 - 0.00017 21.6 28.0 0.076 13.2 2.2 4.8 4 0 0 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.3 T132268_2 - 0.0031 17.1 39.8 0.95 9.2 0.0 8.9 8 0 0 8 8 8 2 zinc-finger C2H2-type zf-C2HC_2 PF13913.4 T132268_2 - 0.0046 16.7 35.9 0.95 9.3 0.1 8.2 8 0 0 8 8 8 3 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.5 T132268_2 - 0.0052 17.0 39.1 1.2 9.4 1.0 8.5 4 4 5 9 9 9 3 C2H2 type zinc-finger (2 copies) IZUMO PF15005.4 T132268_2 - 0.01 16.2 0.1 0.044 14.2 0.0 2.1 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated BolA PF01722.16 T132268_2 - 0.069 13.3 9.7 2.7 8.2 0.0 4.8 5 0 0 5 5 4 0 BolA-like protein DUF3268 PF11672.6 T132268_2 - 0.14 12.4 17.7 0.71 10.1 0.5 4.1 4 0 0 4 4 4 0 zinc-finger-containing domain zf-C2H2_9 PF16293.3 T132268_2 - 0.31 10.8 5.9 11 5.8 0.2 4.3 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2HE PF16278.3 T132268_2 - 0.84 10.0 34.0 0.68 10.3 1.3 6.4 5 1 1 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger JmjC PF02373.20 T375134_2 - 5e-11 42.9 0.4 2.2e-10 40.9 0.4 2.0 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.27 T375134_2 - 2.5e-08 33.5 6.6 5.4e-08 32.5 6.6 1.6 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.4 T375134_2 - 7e-08 32.4 0.0 2.5e-07 30.7 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain PHD_2 PF13831.4 T375134_2 - 2.3 7.7 10.1 0.023 14.1 2.5 1.7 2 0 0 2 2 2 0 PHD-finger PHD_4 PF16866.3 T375134_2 - 2.4 8.2 6.1 6.3 6.8 6.1 1.7 1 0 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.4 T375134_2 - 7.7 6.7 6.4 22 5.3 6.4 1.8 1 0 0 1 1 1 0 Ring finger domain Yae1_N PF09811.7 T337554_1 - 0.045 13.3 3.6 0.081 12.5 3.6 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal FG-GAP PF01839.21 T337554_2 - 3.8 7.6 5.6 2.7e+02 1.7 0.1 4.5 4 0 0 4 4 4 0 FG-GAP repeat CLASP_N PF12348.6 T103605_2 - 6.5e-09 35.6 1.9 2.7e-05 23.7 0.5 3.0 3 0 0 3 3 3 2 CLASP N terminal HEAT_2 PF13646.4 T103605_2 - 1.5e-05 25.2 5.0 1.1 9.6 0.0 4.6 4 1 0 4 4 4 3 HEAT repeats Cnd1 PF12717.5 T103605_2 - 0.024 14.5 5.4 7.8 6.3 0.2 4.2 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 NUC173 PF08161.10 T103605_2 - 0.16 11.5 4.9 0.48 9.9 0.2 2.7 3 0 0 3 3 3 0 NUC173 domain HEAT PF02985.20 T103605_2 - 0.64 10.3 11.6 2.9 8.2 0.2 6.2 7 0 0 7 7 7 0 HEAT repeat HEAT_EZ PF13513.4 T103605_2 - 3.6 8.0 11.3 3.2 8.2 0.1 5.3 5 1 0 5 5 5 0 HEAT-like repeat IRF-2BP1_2 PF11261.6 T033172_3 - 2.4e-34 116.5 1.2 6e-34 115.2 1.2 1.7 1 0 0 1 1 1 1 Interferon regulatory factor 2-binding protein zinc finger zf-C3HC4 PF00097.23 T033172_3 - 1.3 8.8 14.6 0.0049 16.6 5.1 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pam16 PF03656.11 T126485_3 - 1.2e-59 199.7 1.4 1.7e-59 199.3 1.4 1.1 1 0 0 1 1 1 1 Pam16 FGF PF00167.16 T116488_2 - 9.6e-35 119.3 0.2 2.1e-34 118.2 0.2 1.5 1 0 0 1 1 1 1 Fibroblast growth factor E1_dh PF00676.18 T372123_1 - 3.4e-124 413.6 0.0 4.4e-124 413.2 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.4 T372123_1 - 0.0017 17.5 0.0 0.0034 16.5 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase PDZ PF00595.22 T244717_1 - 4.1e-49 164.7 3.4 3.2e-13 49.7 0.0 4.9 5 0 0 5 5 5 4 PDZ domain (Also known as DHR or GLGF) MAGI_u5 PF16666.3 T244717_1 - 9.1e-36 122.8 9.7 9.1e-36 122.8 9.7 3.2 2 0 0 2 2 2 1 Unstructured region on MAGI MAGI_u1 PF16663.3 T244717_1 - 1.9e-32 110.9 3.2 9.4e-32 108.6 3.2 2.3 1 0 0 1 1 1 1 Unstructured region on MAGI PDZ_2 PF13180.4 T244717_1 - 3e-21 75.4 0.0 0.00087 19.4 0.0 5.1 5 0 0 5 5 5 4 PDZ domain WW PF00397.24 T244717_1 - 4.7e-18 64.7 3.9 6.7e-10 38.6 0.4 2.7 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 T244717_1 - 2.9e-10 40.0 0.0 2.9e-10 40.0 0.0 2.2 2 0 0 2 2 2 1 Guanylate kinase Tricorn_PDZ PF14685.4 T244717_1 - 0.0008 19.2 3.0 2.4 8.1 0.0 3.8 4 0 0 4 4 4 2 Tricorn protease PDZ domain Serglycin PF04360.10 T244717_1 - 0.061 13.1 0.4 0.12 12.2 0.4 1.4 1 0 0 1 1 1 0 Serglycin DUF853 PF05872.10 T244717_1 - 1.8 6.9 4.0 3.1 6.2 4.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Folate_rec PF03024.12 T031082_1 - 1.9e-11 44.0 5.6 3.2e-11 43.3 5.6 1.4 1 0 0 1 1 1 1 Folate receptor family GSDH PF07995.9 T031082_2 - 1.9e-25 89.8 0.0 2.7e-25 89.3 0.0 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase DED PF01335.19 T062918_3 - 2.3e-23 82.1 2.8 2.3e-23 82.1 2.8 1.8 2 0 0 2 2 2 1 Death effector domain Death PF00531.20 T062918_3 - 5.2e-22 77.7 1.4 6.5e-22 77.4 0.2 1.7 2 0 0 2 2 2 1 Death domain CLTH PF10607.7 T294624_1 - 2.3e-31 108.5 0.0 4.1e-31 107.7 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Rtf2 PF04641.10 T294624_1 - 0.015 14.5 0.0 0.023 13.9 0.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Sec15 PF04091.10 T294624_1 - 0.14 11.4 0.1 0.21 10.8 0.1 1.1 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like IQ_SEC7_PH PF16453.3 T071192_1 - 7e-60 200.9 1.2 1.2e-59 200.2 1.2 1.4 1 0 0 1 1 1 1 PH domain Sec7 PF01369.18 T071192_1 - 5.9e-56 189.0 0.0 8.3e-56 188.5 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain Ank_2 PF12796.5 T120460_3 - 5.7e-15 55.5 0.4 1.2e-12 48.1 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T120460_3 - 4.3e-14 52.5 0.2 3.1e-05 24.3 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 T120460_3 - 2.8e-11 43.3 0.6 7.2e-05 22.9 0.0 3.6 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 T120460_3 - 4.3e-11 42.6 0.3 0.00013 22.2 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.4 T120460_3 - 2.7e-08 33.3 0.1 0.025 14.9 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat DBP PF12361.6 T267989_3 - 0.63 9.5 7.0 0.89 9.0 7.0 1.1 1 0 0 1 1 1 0 Duffy-antigen binding protein WD40 PF00400.30 T243163_2 - 1.4e-24 85.8 15.9 0.00026 21.6 0.4 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T243163_2 - 0.0066 16.6 0.1 5.6 7.2 0.0 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4200 PF13863.4 T249739_1 - 1.4e-32 112.4 15.0 1.4e-32 112.4 15.0 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4200) DNA_photolyase PF00875.16 T249739_1 - 0.0042 17.0 3.4 0.0071 16.2 0.2 2.2 2 0 0 2 2 2 1 DNA photolyase Mis12 PF05859.10 T249739_2 - 0.32 10.9 2.3 0.55 10.2 2.3 1.3 1 0 0 1 1 1 0 Mis12 protein DUF342 PF03961.11 T249739_2 - 3.1 6.2 6.6 4.1 5.8 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IL1 PF00340.17 T197041_1 - 2.6e-18 65.7 0.1 4.6e-18 64.9 0.1 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 RhoGEF PF00621.18 T302759_2 - 3.2e-44 151.2 1.1 3.2e-44 151.2 1.1 1.6 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.19 T302759_2 - 2.1e-17 62.8 10.2 2.1e-17 62.8 10.2 2.0 2 0 0 2 2 2 1 FYVE zinc finger PH PF00169.27 T302759_2 - 4.1e-17 62.5 0.0 6.9e-09 36.0 0.0 2.5 2 0 0 2 2 2 2 PH domain FYVE_2 PF02318.14 T302759_2 - 1.1e-05 25.5 3.0 2.9e-05 24.1 3.0 1.7 1 0 0 1 1 1 1 FYVE-type zinc finger IQ_SEC7_PH PF16453.3 T302759_2 - 0.00079 19.3 0.1 0.0016 18.3 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_13 PF16652.3 T302759_2 - 0.0012 18.6 0.2 1.1 9.0 0.0 2.7 2 1 0 2 2 2 2 Pleckstrin homology domain C1_1 PF00130.20 T302759_2 - 0.028 14.2 5.8 0.11 12.2 5.8 2.1 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) IBR PF01485.19 T302759_2 - 3.4 7.8 8.8 0.69 10.0 2.3 2.7 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain LRR_6 PF13516.4 T360800_1 - 2.1e-09 36.5 10.0 0.009 15.9 0.1 5.8 5 0 0 5 5 5 3 Leucine Rich repeat Cortex-I_coil PF09304.8 T360800_1 - 0.052 13.6 6.3 0.026 14.6 3.2 2.1 2 0 0 2 2 2 0 Cortexillin I, coiled coil ATPase PF06745.11 T360800_1 - 0.064 12.5 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 KaiC DUF3122 PF11320.6 T360800_1 - 0.085 12.8 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3122) Myosin_tail_1 PF01576.17 T141692_1 - 1.8e-147 492.9 273.6 2.2e-147 492.6 273.6 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 T141692_1 - 2.6e-113 379.5 33.6 2.5e-82 277.1 0.0 4.7 5 0 0 5 5 5 3 Myosin head (motor domain) IQ PF00612.25 T141692_1 - 0.049 13.3 0.0 0.31 10.8 0.0 2.4 2 0 0 2 2 2 0 IQ calmodulin-binding motif Anoctamin PF04547.10 T141692_1 - 0.063 11.9 2.8 0.19 10.3 2.8 1.8 1 0 0 1 1 1 0 Calcium-activated chloride channel Toxin_18 PF08087.9 T141692_1 - 0.33 10.8 3.0 1.2 9.0 3.0 2.0 1 0 0 1 1 1 0 Conotoxin O-superfamily Reo_sigmaC PF04582.10 T141692_1 - 3.5 6.8 77.5 0.12 11.6 3.7 8.6 1 1 7 10 10 10 0 Reovirus sigma C capsid protein Myosin_head PF00063.19 T141692_2 - 0.056 11.5 0.0 0.074 11.1 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) Myosin_head PF00063.19 T141692_3 - 8.6e-16 57.2 0.1 1.2e-15 56.7 0.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Calpain_inhib PF00748.17 T286381_3 - 3.4e-116 383.3 109.3 6.4e-38 130.1 18.6 6.2 4 2 2 6 6 6 5 Calpain inhibitor AMP-binding PF00501.26 T072940_1 - 1e-34 119.8 0.0 1.3e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 T072940_1 - 2.7e-22 79.4 1.1 4.4e-22 78.7 1.1 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sulfotransfer_1 PF00685.25 T234880_2 - 1.8e-15 57.0 0.1 2.5e-15 56.5 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain FdsD PF11390.6 T234880_2 - 0.0071 16.5 0.3 4.8 7.4 0.3 2.4 2 0 0 2 2 2 2 NADH-dependant formate dehydrogenase delta subunit FdsD Sulfotransfer_3 PF13469.4 T234880_2 - 0.034 14.4 0.0 0.05 13.8 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase family Sulfotransfer_1 PF00685.25 T234880_3 - 7e-23 81.3 0.1 1.5e-18 67.1 0.0 2.1 2 0 0 2 2 2 2 Sulfotransferase domain ADAM_spacer1 PF05986.12 T118968_2 - 2e-35 121.1 0.1 3e-35 120.6 0.1 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.17 T118968_2 - 3.8e-24 84.5 89.0 2.1e-06 27.7 5.8 8.3 8 0 0 8 8 8 7 Thrombospondin type 1 domain PLAC PF08686.9 T118968_2 - 2.6e-08 34.3 15.0 2.6e-08 34.3 15.0 2.7 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain 4_1_CTD PF05902.11 T311316_2 - 3e-50 168.8 9.6 3e-50 168.8 9.6 2.4 2 0 0 2 2 2 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.8 T311316_2 - 1.1e-23 83.2 0.0 2.3e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 T311316_2 - 1.5e-20 72.8 0.1 4e-20 71.4 0.1 1.8 1 0 0 1 1 1 1 FERM N-terminal domain FA PF08736.9 T311316_2 - 6e-19 67.7 5.0 2.5e-18 65.8 5.0 2.2 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.16 T311316_2 - 3e-18 66.2 0.0 3e-18 66.2 0.0 2.8 2 1 0 2 2 2 1 FERM central domain PIEZO PF15917.3 T158714_1 - 4.9e-102 340.1 3.2 4.9e-102 340.1 3.2 4.4 5 0 0 5 5 5 1 Piezo Piezo_RRas_bdg PF12166.6 T158714_3 - 3.6e-160 533.7 4.8 5.5e-160 533.1 4.8 1.3 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain Ig_3 PF13927.4 T328336_1 - 3.1e-23 82.1 0.4 1.7e-14 54.0 0.3 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T328336_1 - 1.3e-18 66.7 0.0 1e-11 44.6 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 T328336_1 - 2.3e-14 53.2 0.1 1.8e-08 34.3 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T328336_1 - 2.6e-12 46.8 0.7 7.2e-08 32.5 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 T328336_1 - 3.2e-12 46.4 0.1 3.2e-05 23.9 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin V-set domain C1-set PF07654.13 T328336_1 - 0.0046 17.3 0.1 0.013 15.8 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 T328336_1 - 0.088 12.8 0.0 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain 7tm_2 PF00002.22 T169613_1 - 1.2e-51 175.2 19.5 2.2e-51 174.4 19.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 T169613_1 - 1.3e-11 44.8 8.2 4.4e-11 43.1 8.2 2.0 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF_CA PF07645.13 T169613_3 - 4.8e-30 103.4 59.5 2.7e-14 52.9 7.1 5.1 5 0 0 5 5 5 3 Calcium-binding EGF domain cEGF PF12662.5 T169613_3 - 1.3e-15 56.8 31.7 5.3e-08 32.5 0.4 5.6 5 0 0 5 5 5 4 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.5 T169613_3 - 1.6e-09 37.5 34.7 0.0011 18.9 2.3 4.9 4 0 0 4 4 4 4 MSP1 EGF domain 1 EGF_3 PF12947.5 T169613_3 - 6.9e-08 32.4 38.8 0.00035 20.6 2.8 5.2 5 0 0 5 5 5 3 EGF domain EGF PF00008.25 T169613_3 - 1.6e-06 28.2 5.6 1.6e-06 28.2 5.6 5.7 5 0 0 5 5 5 3 EGF-like domain hEGF PF12661.5 T169613_3 - 7.9e-05 23.0 17.9 0.00032 21.1 5.1 6.4 6 0 0 6 6 6 4 Human growth factor-like EGF FXa_inhibition PF14670.4 T169613_3 - 0.62 10.3 55.5 0.015 15.4 6.8 6.1 6 0 0 6 6 6 0 Coagulation Factor Xa inhibitory site Pkinase_Tyr PF07714.15 T175457_2 - 8.3e-11 41.5 0.0 1.2e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T175457_2 - 0.0056 15.9 0.0 0.0087 15.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.23 T175457_3 - 3.9e-45 154.1 0.0 5.1e-45 153.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T175457_3 - 9.2e-41 139.7 0.0 1.2e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SH3_9 PF14604.4 T175457_3 - 2.6e-14 52.6 0.1 5.1e-14 51.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T175457_3 - 9e-11 41.1 0.0 1.9e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 T175457_3 - 1.2e-10 40.8 0.0 3.5e-10 39.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Cast PF10174.7 T243906_1 - 0 1249.3 153.9 0 1248.7 153.9 1.3 1 1 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone AAA_13 PF13166.4 T243906_1 - 0.00098 17.8 25.3 0.00098 17.8 25.3 4.4 1 1 4 5 5 5 1 AAA domain IncA PF04156.12 T243906_1 - 0.0025 17.5 18.4 0.0025 17.5 18.4 8.6 1 1 6 8 8 8 4 IncA protein Ank_4 PF13637.4 T025320_3 - 3.2e-11 43.4 0.8 2.7e-07 30.9 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 T025320_3 - 5.5e-10 39.6 0.5 2.3e-09 37.6 0.3 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T025320_3 - 1e-08 34.6 0.2 0.0028 17.9 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 T025320_3 - 0.00043 20.4 2.9 0.015 15.5 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 T025320_3 - 0.0026 18.0 0.1 0.88 10.0 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Asn_synthase PF00733.19 T204630_1 - 8e-16 58.5 0.0 6e-08 32.6 0.0 3.1 2 1 0 2 2 2 2 Asparagine synthase GATase_7 PF13537.4 T204630_1 - 6.4e-05 22.7 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Ank_3 PF13606.4 T204630_1 - 0.031 14.7 0.1 0.092 13.2 0.1 1.9 1 0 0 1 1 1 0 Ankyrin repeat Ank_5 PF13857.4 T204630_1 - 0.13 12.5 0.1 0.44 10.9 0.0 1.8 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Arm PF00514.21 T204630_3 - 1.8e-16 59.4 7.6 0.0034 17.2 0.1 5.8 5 0 0 5 5 5 5 Armadillo/beta-catenin-like repeat Ank_4 PF13637.4 T204630_3 - 0.0046 17.4 0.0 0.013 16.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) HEAT_EZ PF13513.4 T204630_3 - 0.0089 16.3 0.2 1.9 8.9 0.0 3.9 4 0 0 4 4 4 1 HEAT-like repeat Ank_2 PF12796.5 T204630_3 - 0.012 16.1 0.0 0.032 14.7 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Atx10homo_assoc PF09759.7 T204630_3 - 0.019 14.9 3.9 0.054 13.4 1.8 2.5 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Ank_3 PF13606.4 T204630_3 - 0.057 13.8 0.0 1.2 9.7 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeat Arm_2 PF04826.11 T204630_3 - 1.1 8.6 4.4 1.6 8.0 0.2 2.1 1 1 1 2 2 2 0 Armadillo-like ApoO PF09769.7 T376980_3 - 1.7e-34 118.5 0.0 2.8e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 Apolipoprotein O DUF4691 PF15762.3 T134802_3 - 3.3e-83 278.2 18.3 2.6e-72 242.6 14.2 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4691) Rib_recp_KP_reg PF05104.10 T134802_3 - 0.88 10.5 12.9 1.5 9.7 12.9 1.3 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Peptidase_M13_N PF05649.11 T001395_1 - 2.8e-118 395.8 0.0 4.1e-118 395.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.19 T001395_1 - 2.2e-53 180.8 1.6 2.2e-53 180.8 1.6 1.5 2 0 0 2 2 2 1 Peptidase family M13 ERAP1_C PF11838.6 T001395_1 - 0.0036 16.8 0.1 0.23 10.8 0.0 2.4 1 1 1 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M48 PF01435.16 T001395_1 - 0.07 12.8 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M48 Peptidase_M13 PF01431.19 T001395_3 - 4.7e-12 45.8 0.0 6.5e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 EF-hand_1 PF00036.30 T332838_1 - 6.6e-12 44.0 22.9 0.02 14.3 0.4 6.7 7 0 0 7 7 7 5 EF hand EF-hand_7 PF13499.4 T332838_1 - 7.4e-12 45.4 23.2 1.7e-05 25.1 0.5 4.1 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 T332838_1 - 1.1e-08 34.2 13.1 0.12 12.3 0.0 6.7 6 0 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.4 T332838_1 - 2e-08 33.3 26.5 0.021 14.2 0.0 6.4 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.4 T332838_1 - 3.8e-06 26.5 7.1 0.017 14.8 0.0 4.1 4 0 0 4 4 4 2 EF-hand domain pair DUF3699 PF12480.6 T332838_2 - 3.6e-09 36.5 0.1 7.9e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3699) p450 PF00067.20 T329229_2 - 2.2e-89 300.2 0.4 3.1e-89 299.7 0.4 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 T329229_3 - 9.7e-22 77.2 0.0 1.4e-21 76.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1725 PF08333.9 T329229_3 - 0.00093 18.7 5.0 0.00093 18.7 5.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) Pkinase_Tyr PF07714.15 T073898_2 - 1.4e-58 198.1 0.0 2.2e-58 197.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T073898_2 - 1.1e-29 103.5 0.0 1.4e-29 103.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 T073898_2 - 0.0095 15.1 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-C3HC4_3 PF13920.4 T126554_2 - 1.9e-13 49.9 9.3 1.9e-13 49.9 9.3 4.2 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Bromodomain PF00439.23 T017753_2 - 7.5e-22 77.1 0.3 1.5e-21 76.1 0.3 1.5 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.22 T017753_2 - 7.1e-11 41.9 34.2 5.4e-09 35.9 6.7 4.2 3 0 0 3 3 3 2 B-box zinc finger PHD PF00628.27 T017753_2 - 3.4e-07 29.9 10.0 3.4e-07 29.9 10.0 4.7 5 0 0 5 5 5 1 PHD-finger zf-RING_UBOX PF13445.4 T017753_2 - 3.9e-07 29.8 1.1 3.9e-07 29.8 1.1 3.3 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.4 T017753_2 - 0.00014 21.6 3.2 0.00014 21.6 3.2 3.9 3 1 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.4 T017753_2 - 0.0043 17.1 5.7 0.0043 17.1 5.7 4.6 4 1 0 4 4 4 1 Ring finger domain Spectrin PF00435.19 T017753_2 - 1.4 9.3 6.6 0.6 10.5 2.2 2.6 2 0 0 2 2 2 0 Spectrin repeat Peptidase_S49_N PF08496.8 T172680_2 - 3 7.8 4.0 4.9 7.1 4.0 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal zf-C2H2_assoc PF16606.3 T172680_3 - 2.6e-40 136.4 16.8 2.6e-40 136.4 16.8 2.2 2 0 0 2 2 1 1 Unstructured conserved, between two C2H2-type zinc-fingers zf-C2H2 PF00096.24 T172680_3 - 1.6e-33 113.2 73.7 4e-05 23.7 4.0 11.1 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T172680_3 - 1.3e-21 75.3 88.0 0.0039 17.8 2.8 12.1 12 0 0 12 12 12 9 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T172680_3 - 6.5e-20 70.4 60.2 4.9e-07 29.2 0.9 10.2 10 0 0 10 10 10 4 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.4 T172680_3 - 1.5e-19 69.3 83.5 1.6e-07 31.3 2.4 13.3 13 0 0 13 13 13 6 Zinc-finger double domain GAGA PF09237.9 T172680_3 - 0.00045 19.8 5.5 1.2 8.8 0.1 5.3 4 1 1 5 5 5 1 GAGA factor zf-Di19 PF05605.10 T172680_3 - 0.00098 19.2 56.1 0.013 15.6 1.6 8.2 7 3 1 8 8 8 5 Drought induced 19 protein (Di19), zinc-binding DUF3268 PF11672.6 T172680_3 - 0.0045 17.2 8.8 0.06 13.5 1.2 3.4 3 0 0 3 3 3 2 zinc-finger-containing domain CpXC PF14353.4 T172680_3 - 0.21 11.5 22.8 18 5.2 0.5 6.6 4 3 2 6 6 6 0 CpXC protein TerY_C PF15616.4 T172680_3 - 0.27 11.2 3.6 18 5.3 0.0 3.1 3 0 0 3 3 3 0 TerY-C metal binding domain Zn-ribbon_8 PF09723.8 T172680_3 - 5.6 7.0 37.2 1.6 8.8 3.8 6.3 6 1 0 6 6 6 0 Zinc ribbon domain SAM_2 PF07647.15 T350182_3 - 3.9e-17 62.0 1.0 6e-17 61.4 1.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 T350182_3 - 1e-10 41.7 0.8 1e-10 41.7 0.8 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 T350182_3 - 2e-08 33.9 0.2 3.7e-08 33.1 0.2 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain EGF_CA PF07645.13 T269553_1 - 1.1e-10 41.5 6.0 2.2e-10 40.4 6.0 1.5 1 0 0 1 1 1 1 Calcium-binding EGF domain EGF_3 PF12947.5 T269553_1 - 1.5e-06 28.1 4.6 3.1e-06 27.1 4.6 1.5 1 0 0 1 1 1 1 EGF domain EGF PF00008.25 T269553_1 - 0.00049 20.2 3.4 0.0014 18.8 3.4 1.8 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.5 T269553_1 - 0.016 15.7 3.9 0.066 13.8 3.9 2.2 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_MSP1_1 PF12946.5 T269553_1 - 0.025 14.5 3.7 0.053 13.4 3.7 1.6 1 0 0 1 1 1 0 MSP1 EGF domain 1 FXa_inhibition PF14670.4 T269553_1 - 0.043 14.0 5.3 0.1 12.8 5.3 1.6 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.9 T269553_1 - 0.17 12.1 2.4 0.4 10.9 2.4 1.6 1 0 0 1 1 1 0 Pvs28 EGF domain cEGF PF12662.5 T269553_1 - 10 6.1 9.1 0.22 11.4 2.0 2.0 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_3 PF12947.5 T269553_3 - 0.00014 21.8 3.3 0.0003 20.8 3.3 1.5 1 0 0 1 1 1 1 EGF domain EGF PF00008.25 T269553_3 - 0.00015 21.9 3.4 0.00048 20.2 3.4 2.0 1 0 0 1 1 1 1 EGF-like domain IRF-3 PF10401.7 T101671_1 - 5e-38 130.6 0.0 4.8e-26 91.5 0.0 2.2 2 0 0 2 2 2 2 Interferon-regulatory factor 3 IRF PF00605.15 T101671_1 - 1.8e-36 124.5 0.2 5.2e-36 123.0 0.2 1.9 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Rad21_Rec8 PF04824.14 T101671_1 - 1.7e-06 27.1 0.0 3.5e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein HOIP-UBA PF16678.3 T101671_3 - 4.1e-51 172.9 0.1 7e-51 172.1 0.1 1.4 1 0 0 1 1 1 1 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase Rad21_Rec8_N PF04825.11 T101671_3 - 4.5e-23 81.4 0.0 9.3e-23 80.4 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein PUB PF09409.8 T101671_3 - 3.6e-13 49.1 0.0 6.7e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 PUB domain IBR PF01485.19 T101671_3 - 3.3e-07 30.3 7.2 3.3e-07 30.3 7.2 6.0 5 2 1 6 6 6 3 IBR domain, a half RING-finger domain zf-RanBP PF00641.16 T101671_3 - 7.7e-05 21.8 33.1 0.0023 17.1 0.9 4.9 4 0 0 4 4 4 2 Zn-finger in Ran binding protein and others Rad21_Rec8 PF04824.14 T101671_3 - 0.00047 19.3 0.0 0.00087 18.4 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein NMD3 PF04981.11 T101671_3 - 7 5.9 12.5 13 5.0 11.6 2.0 1 1 1 2 2 2 0 NMD3 family APG6 PF04111.10 T147966_3 - 1.9e-129 431.4 11.4 2.4e-129 431.1 11.4 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 BH3 PF15285.4 T147966_3 - 8.8e-17 60.3 0.2 1.6e-16 59.5 0.2 1.4 1 0 0 1 1 1 1 Beclin-1 BH3 domain, Bcl-2-interacting MT PF12777.5 T147966_3 - 0.017 14.0 8.6 0.028 13.3 8.6 1.2 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor HAUS-augmin3 PF14932.4 T147966_3 - 0.025 14.0 17.8 0.042 13.2 17.8 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 EzrA PF06160.10 T147966_3 - 0.32 9.0 19.3 0.45 8.5 19.3 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA ERM PF00769.17 T147966_3 - 0.36 10.5 22.5 0.63 9.7 22.5 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Suppressor_APC PF11414.6 T147966_3 - 0.41 10.6 11.9 1.1 9.3 11.9 1.7 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein Exonuc_VII_L PF02601.13 T147966_3 - 0.46 9.9 7.1 0.68 9.3 7.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FTA4 PF13093.4 T147966_3 - 1.5 8.5 10.7 2.6 7.8 10.7 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Spc7 PF08317.9 T147966_3 - 3.2 6.4 23.5 5 5.8 23.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein IFT57 PF10498.7 T147966_3 - 3.2 6.5 17.9 5.3 5.8 17.9 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 V_ATPase_I PF01496.17 T147966_3 - 3.3 5.4 10.0 4.6 4.9 10.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GAS PF13851.4 T147966_3 - 3.9 6.6 27.2 8.6 5.5 26.1 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Ima1_N PF09779.7 T147966_3 - 5.4 7.7 12.0 9.2 7.0 2.2 2.9 1 1 1 2 2 2 0 Ima1 N-terminal domain DUF342 PF03961.11 T147966_3 - 9.6 4.5 18.0 2.9 6.3 10.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF342) zf-H2C2_2 PF13465.4 T206980_3 - 5.1e-08 32.9 37.4 7.7e-07 29.2 2.8 6.3 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.24 T206980_3 - 7.1e-08 32.4 41.4 0.00071 19.8 1.3 6.6 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T206980_3 - 1.3e-05 25.5 35.3 0.009 16.6 1.1 6.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T206980_3 - 0.0028 17.2 0.9 0.0028 17.2 0.9 4.8 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 T206980_3 - 6.8 6.6 27.2 0.46 10.4 5.6 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger Acetyltransf_1 PF00583.23 T126316_1 - 2.4e-13 50.2 0.0 3.8e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 T126316_1 - 1.2e-07 31.9 0.0 2.7e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 T126316_1 - 5.6e-07 29.4 0.1 3.1e-06 27.0 0.1 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 T126316_1 - 1.2e-05 25.0 0.0 2.2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein RRM_1 PF00076.20 T013039_2 - 4.9e-06 26.1 0.0 8.5e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RVT_1 PF00078.25 T202531_2 - 3.7e-11 42.8 0.1 9.7e-11 41.5 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FCH PF00611.21 T202531_2 - 1.5e-10 41.1 2.4 1.5e-10 41.1 2.4 3.1 3 0 0 3 3 3 2 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.4 T202531_3 - 1.4e-16 59.9 0.0 2.6e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T202531_3 - 3.9e-16 58.2 0.1 8.7e-16 57.1 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 T202531_3 - 5.8e-11 41.8 0.0 1.2e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain HR1 PF02185.14 T202531_3 - 0.0092 15.9 0.9 0.019 14.9 0.9 1.5 1 0 0 1 1 1 1 Hr1 repeat Metal_resist PF13801.4 T249105_1 - 0.0023 18.0 1.7 0.0023 18.0 1.7 9.2 10 0 0 10 10 10 2 Heavy-metal resistance HALZ PF02183.16 T249105_1 - 0.0026 17.8 2.3 0.0026 17.8 2.3 29.5 30 2 2 32 32 32 8 Homeobox associated leucine zipper Cadherin PF00028.15 T279743_3 - 5e-77 254.3 2.2 7.5e-18 64.6 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 T279743_3 - 8.4e-54 181.3 0.6 1.4e-53 180.6 0.6 1.3 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.10 T279743_3 - 2.6e-05 23.8 0.0 0.04 13.6 0.0 3.2 3 0 0 3 3 3 2 Cadherin-like Folate_carrier PF01770.16 T228056_2 - 1.2e-167 557.7 8.3 1.5e-167 557.4 8.3 1.1 1 0 0 1 1 1 1 Reduced folate carrier TLV_coat PF00429.17 T333691_2 - 0.0019 16.9 0.2 0.0027 16.3 0.2 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Aldo_ket_red PF00248.19 T333691_3 - 3.3e-52 177.3 0.0 4.6e-52 176.8 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family ATP-synt_S1 PF05827.10 T285072_3 - 3.2e-35 121.0 0.1 5e-35 120.3 0.1 1.3 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Lamp PF01299.15 T285072_3 - 4.6e-06 26.3 0.0 8.3e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) DUF4199 PF13858.4 T285072_3 - 0.14 12.4 0.1 0.14 12.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Nramp PF01566.16 T078513_3 - 3.2e-119 397.9 13.6 5e-119 397.3 13.6 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Lipase_3 PF01764.23 T318120_1 - 3.7e-14 52.7 0.0 6.1e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.18 T318120_1 - 0.013 15.1 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Hydrolase_4 PF12146.6 T318120_1 - 0.19 10.9 0.8 0.25 10.5 0.0 1.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 RabGAP-TBC PF00566.16 T062034_1 - 1.8e-22 79.9 0.0 2.8e-17 63.0 0.0 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Pkinase PF00069.23 T062034_2 - 8.2e-68 228.5 0.0 1e-67 228.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T062034_2 - 9.5e-33 113.4 0.0 1.3e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 T062034_2 - 3.4e-09 37.1 2.8 9e-09 35.8 2.8 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 T062034_2 - 0.0031 16.7 0.0 0.0044 16.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like ATPgrasp_Ter PF15632.4 T062034_3 - 2.9e-11 42.5 0.0 4.4e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.4 T062034_3 - 1.6e-07 30.9 0.0 2.2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain RabGAP-TBC PF00566.16 T062034_3 - 5.2e-06 26.1 0.0 0.00032 20.3 0.0 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain ATP-grasp_3 PF02655.12 T062034_3 - 0.0026 17.7 0.0 0.0041 17.0 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain PLA2G12 PF06951.9 T269490_1 - 9.8e-85 282.9 8.9 1.5e-84 282.3 8.9 1.2 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) Peptidase_C14 PF00656.20 T269490_3 - 3.2e-48 164.7 0.0 4.3e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Ldl_recept_a PF00057.16 T335513_1 - 1.3e-66 220.4 178.9 1e-11 44.7 9.7 15.1 14 1 1 15 15 15 11 Low-density lipoprotein receptor domain class A TSP_1 PF00090.17 T335513_1 - 5.6e-49 164.0 141.3 1.6e-11 44.1 8.8 11.5 9 0 0 9 9 9 8 Thrombospondin type 1 domain C8 PF08742.9 T335513_1 - 7.8e-30 103.0 26.7 1.1e-16 60.8 7.6 5.1 4 0 0 4 4 4 2 C8 domain VWD PF00094.23 T335513_1 - 3e-23 82.7 0.0 6e-15 55.7 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type D domain TIL PF01826.15 T335513_1 - 5.8e-20 71.2 76.8 2.1e-09 37.3 15.1 19.1 16 4 3 19 19 19 4 Trypsin Inhibitor like cysteine rich domain F5_F8_type_C PF00754.23 T335513_1 - 1e-18 67.6 0.0 1.8e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain Pacifastin_I PF05375.11 T335513_1 - 1.6e-06 27.6 4.3 1.6e-06 27.6 4.3 8.8 8 0 0 8 8 8 3 Pacifastin inhibitor (LCMII) VWC PF00093.16 T335513_1 - 0.00064 19.9 13.4 0.00064 19.9 13.4 17.3 16 4 2 18 18 18 3 von Willebrand factor type C domain C8 PF08742.9 T335513_2 - 4.4e-17 62.1 4.4 1.7e-16 60.3 4.4 2.1 1 0 0 1 1 1 1 C8 domain TIL PF01826.15 T335513_2 - 6.1e-11 42.3 26.1 6.7e-10 38.9 14.6 5.9 7 0 0 7 7 7 2 Trypsin Inhibitor like cysteine rich domain VWD PF00094.23 T335513_3 - 9e-43 146.1 0.0 8.5e-21 74.7 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type D domain TIL PF01826.15 T335513_3 - 9.6e-06 25.6 6.9 9.6e-06 25.6 6.9 3.2 2 0 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Pacifastin_I PF05375.11 T335513_3 - 4.2 7.0 10.3 0.057 13.0 1.9 2.4 2 0 0 2 2 2 0 Pacifastin inhibitor (LCMII) Peptidase_M28 PF04389.15 T058514_3 - 5.1e-16 58.8 0.0 7.3e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.13 T058514_3 - 8.8e-14 51.5 1.1 5.1e-11 42.6 0.1 2.3 1 1 1 2 2 2 2 Transferrin receptor-like dimerisation domain PA PF02225.20 T058514_3 - 3.6e-13 49.3 0.1 9.2e-13 48.0 0.0 1.7 2 0 0 2 2 2 1 PA domain BC10 PF06726.10 T217386_2 - 1.2e-24 86.1 10.2 4.9e-24 84.2 10.2 2.2 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 zf-C2H2 PF00096.24 T177959_2 - 9.2e-12 44.6 32.2 9.3e-05 22.6 3.5 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T177959_2 - 5.3e-09 36.0 32.5 0.0041 17.7 0.9 4.9 4 0 0 4 4 4 4 C2H2-type zinc finger ELM2 PF01448.22 T177959_2 - 1.4e-06 28.8 0.0 3.3e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 ELM2 domain zf-H2C2_2 PF13465.4 T177959_2 - 0.00017 21.7 31.5 0.0019 18.4 3.4 5.5 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_6 PF13912.4 T177959_2 - 0.00019 21.1 3.4 0.00019 21.1 3.4 3.8 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T177959_2 - 0.00091 19.3 12.5 0.16 12.2 0.2 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T177959_2 - 0.31 11.7 3.9 0.76 10.4 0.7 2.4 2 0 0 2 2 2 0 zinc-ribbon family zf-C2H2_8 PF15909.3 T177959_2 - 1.5 9.0 9.7 1.9 8.7 0.1 3.2 2 1 0 2 2 2 0 C2H2-type zinc ribbon Myb_DNA-binding PF00249.29 T177959_3 - 5.9e-05 23.0 0.1 0.00015 21.7 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-C2H2_6 PF13912.4 T177959_3 - 0.028 14.2 0.1 0.072 12.9 0.1 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_4 PF13894.4 T177959_3 - 0.088 13.6 1.0 0.33 11.8 1.0 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.24 T177959_3 - 0.17 12.3 1.0 0.53 10.7 1.0 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type Arm PF00514.21 T170831_1 - 1.9e-13 49.8 13.0 4.1e-05 23.3 0.0 7.0 6 2 1 7 7 7 4 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.7 T170831_1 - 0.00059 19.7 0.9 0.79 9.7 0.1 4.2 3 1 1 4 4 4 2 Spinocerebellar ataxia type 10 protein domain Drf_GBD PF06371.11 T170831_1 - 0.044 13.2 0.1 0.082 12.3 0.1 1.4 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain Mis14 PF08641.10 T170831_1 - 0.17 12.1 0.4 0.31 11.2 0.4 1.3 1 0 0 1 1 1 0 Kinetochore protein Mis14 like Myco_arth_vir_N PF09610.8 T170831_3 - 1.4 8.9 2.6 2.7 8.0 2.6 1.5 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) FF PF01846.17 T201140_2 - 5.6e-43 144.8 24.7 1.4e-15 57.0 0.5 5.9 6 0 0 6 6 6 5 FF domain WW PF00397.24 T201140_2 - 3.5e-20 71.5 15.9 3.1e-11 42.9 5.4 2.6 2 0 0 2 2 2 2 WW domain MCR_alpha PF02249.15 T201140_2 - 1.2 9.5 3.7 2.6 8.4 3.7 1.5 1 0 0 1 1 1 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain Smg8_Smg9 PF10220.7 T059110_1 - 0.027 12.7 0.1 0.036 12.2 0.1 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Gly_acyl_tr_N PF06021.9 T059110_3 - 1.5e-69 234.1 0.9 2.1e-69 233.6 0.9 1.2 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.8 T059110_3 - 1.2e-41 140.7 0.3 2e-41 140.0 0.3 1.4 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region FR47 PF08445.8 T059110_3 - 0.00015 21.6 0.0 0.00026 20.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein CH PF00307.29 T373031_1 - 0.00041 20.4 0.0 0.00071 19.6 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 T373031_1 - 0.014 15.1 0.0 0.036 13.8 0.0 1.7 1 0 0 1 1 1 0 CAMSAP CH domain TMEM131_like PF12371.6 T373031_3 - 0.044 13.8 0.0 17 5.5 0.0 2.5 2 0 0 2 2 2 0 Transmembrane protein 131-like Pkinase PF00069.23 T140068_2 - 9e-62 208.7 1.1 6.1e-61 205.9 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain CNH PF00780.20 T140068_2 - 6.5e-58 196.4 0.0 9.7e-58 195.8 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 T140068_2 - 1.3e-45 155.6 0.0 2.7e-45 154.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Glyco_transf_7N PF13733.4 T009611_1 - 2.7e-54 182.3 0.0 3.9e-54 181.8 0.0 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 T009611_1 - 6.6e-30 102.5 0.4 6.6e-30 102.5 0.4 2.0 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 T009611_1 - 0.14 11.4 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase like family 2 CCDC24 PF15669.3 T009611_2 - 5.7e-60 202.5 3.2 8.7e-60 201.9 3.2 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family ATP-synt_C PF00137.19 T009611_2 - 4e-22 78.2 31.0 4.4e-13 49.2 10.4 4.3 4 0 0 4 4 4 2 ATP synthase subunit C Diphthamide_syn PF01866.15 T009611_3 - 5.9e-62 209.7 0.0 7.9e-62 209.2 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein 7tm_1 PF00001.19 T246202_3 - 3.8e-70 236.1 8.4 5.6e-70 235.5 8.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ssl1 PF04056.12 T283913_3 - 3.7e-94 313.8 0.1 5e-94 313.4 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.4 T283913_3 - 8e-12 45.6 0.0 1.6e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain C1_4 PF07975.10 T283913_3 - 1.5e-10 41.1 27.7 5.9e-10 39.1 21.1 3.1 2 1 0 2 2 2 1 TFIIH C1-like domain VWA PF00092.26 T283913_3 - 4.1e-06 27.0 0.0 6e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain IBR PF01485.19 T283913_3 - 0.7 10.0 16.0 0.97 9.6 9.9 3.1 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain DZR PF12773.5 T283913_3 - 3.7 7.5 21.9 22 5.0 12.8 3.3 1 1 3 4 4 4 0 Double zinc ribbon Adaptin_N PF01602.18 T231844_2 - 4.5e-164 546.7 15.1 5.7e-164 546.4 15.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 T231844_2 - 3e-68 228.8 8.8 2e-65 219.6 1.4 3.4 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.8 T231844_2 - 1.3e-34 118.5 0.0 2.6e-34 117.5 0.0 1.6 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.4 T231844_2 - 4e-21 75.1 3.2 4.8e-08 33.1 0.0 5.8 3 2 3 6 6 6 4 HEAT repeats HEAT PF02985.20 T231844_2 - 4.5e-11 41.8 8.7 0.013 15.6 0.1 6.7 7 0 0 7 7 7 3 HEAT repeat Alpha_adaptinC2 PF02883.18 T231844_2 - 2.8e-09 37.1 0.5 6.1e-09 36.0 0.5 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd3 PF12719.5 T231844_2 - 1.3e-08 34.3 4.4 2.5e-05 23.5 0.3 2.5 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain Arm PF00514.21 T231844_2 - 1.1e-05 25.2 4.4 0.025 14.5 0.0 4.8 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.7 T231844_2 - 0.00053 20.0 6.3 0.13 12.3 0.0 4.8 2 2 1 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.6 T231844_2 - 0.00056 19.4 1.5 1.3 8.4 0.1 3.7 2 2 0 2 2 2 2 CLASP N terminal Arm_2 PF04826.11 T231844_2 - 0.022 14.1 0.1 0.057 12.7 0.1 1.6 1 0 0 1 1 1 0 Armadillo-like Cohesin_HEAT PF12765.5 T231844_2 - 0.099 12.7 0.0 48 4.2 0.0 3.6 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion UNC45-central PF11701.6 T231844_2 - 0.14 12.0 0.6 3.2 7.5 0.0 2.8 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central HEAT_EZ PF13513.4 T231844_2 - 0.3 11.5 7.4 13 6.3 0.0 5.4 7 0 0 7 7 6 0 HEAT-like repeat Mo25 PF08569.9 T231844_2 - 0.89 8.7 5.3 0.32 10.2 0.3 2.2 2 1 0 2 2 2 0 Mo25-like Sec7_N PF12783.5 T231844_2 - 1.5 8.7 5.1 0.7 9.7 0.4 2.8 2 1 2 4 4 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal RPEL PF02755.13 T006578_2 - 2.2e-23 81.1 20.0 2.7e-08 33.1 3.2 4.7 4 0 0 4 4 4 4 RPEL repeat Complex1_LYR PF05347.13 T288726_2 - 4.4e-05 23.3 0.4 7.2e-05 22.6 0.4 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) I-set PF07679.14 T337746_1 - 0.00015 21.7 0.0 0.00021 21.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain I-set PF07679.14 T337746_2 - 2.7e-22 78.5 0.1 4.5e-22 77.8 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T337746_2 - 2.8e-13 50.1 0.0 5.8e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T337746_2 - 8.2e-09 35.4 0.0 1.7e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T337746_2 - 5.8e-08 32.8 0.0 1.1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 T337746_2 - 4.9e-06 26.5 0.2 0.00032 20.7 0.2 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 T337746_2 - 0.0092 15.9 0.0 0.023 14.6 0.0 1.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.13 T337746_2 - 0.11 12.2 0.2 0.17 11.5 0.2 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 Synapsin PF02078.14 T337746_2 - 0.16 12.2 0.1 0.3 11.3 0.1 1.4 1 0 0 1 1 1 0 Synapsin, N-terminal domain Pkinase_Tyr PF07714.15 T258169_3 - 8.6e-87 290.6 0.0 1.1e-86 290.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase GTPase_binding PF09027.8 T258169_3 - 1.4e-44 149.7 0.6 2.8e-44 148.8 0.6 1.5 1 0 0 1 1 1 1 GTPase binding Pkinase PF00069.23 T258169_3 - 1.5e-41 142.4 0.0 2.6e-41 141.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Inhibitor_Mig-6 PF11555.6 T258169_3 - 2.6e-25 88.1 19.1 2.6e-25 88.1 19.1 4.4 4 1 0 4 4 4 1 EGFR receptor inhibitor Mig-6 SH3_9 PF14604.4 T258169_3 - 6.7e-11 41.7 0.0 1.4e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T258169_3 - 9.6e-05 21.8 0.0 0.00016 21.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain Kinase-like PF14531.4 T258169_3 - 0.00013 21.2 0.0 0.00023 20.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SH3_2 PF07653.15 T258169_3 - 0.00035 20.1 0.5 0.00078 18.9 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain UBA_4 PF14555.4 T258169_3 - 0.029 14.1 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain SPATIAL PF15256.4 T043477_1 - 8.7e-38 130.5 0.0 1.5e-37 129.7 0.0 1.4 1 0 0 1 1 1 1 SPATIAL PKD_channel PF08016.10 T014258_2 - 3.7e-11 42.2 11.9 3.7e-11 42.2 11.9 1.7 2 0 0 2 2 2 1 Polycystin cation channel Glyco_transf_8 PF01501.18 T257831_2 - 0.00013 21.5 0.0 0.0002 20.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 CC190 PF15768.3 T024083_2 - 3.1e-108 361.8 10.1 3.1e-108 361.8 10.1 1.6 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 190 CARMIL_C PF16000.3 T134785_1 - 3.7e-52 177.8 0.4 3.7e-52 177.8 0.4 1.8 2 0 0 2 2 2 1 CARMIL C-terminus Rib_recp_KP_reg PF05104.10 T134785_1 - 2.8 8.9 7.5 12 6.8 7.5 2.1 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region LRR_6 PF13516.4 T134785_3 - 6.2e-13 47.5 18.8 5.1e-05 22.9 0.1 8.7 9 0 0 9 9 9 3 Leucine Rich repeat CARMIL_C PF16000.3 T134785_3 - 6.3e-06 26.0 0.0 1.1e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 CARMIL C-terminus LRR_1 PF00560.31 T134785_3 - 0.0019 18.2 2.7 12 6.7 0.0 6.8 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_4 PF12799.5 T134785_3 - 0.065 13.5 8.5 34 4.9 0.0 5.7 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) PWWP PF00855.15 T342236_1 - 6.2e-42 141.9 6.5 3.2e-21 75.5 1.9 2.7 2 0 0 2 2 2 2 PWWP domain PAP2 PF01569.19 T342236_1 - 4.4e-22 78.2 2.3 7.6e-22 77.4 0.4 2.2 2 0 0 2 2 2 1 PAP2 superfamily SET PF00856.26 T342236_1 - 1.6e-19 70.8 0.1 1.6e-19 70.8 0.1 2.7 2 1 1 3 3 3 1 SET domain PHD PF00628.27 T342236_1 - 3.5e-06 26.7 77.3 0.0013 18.4 9.3 6.6 5 1 1 6 6 6 4 PHD-finger ACBP PF00887.17 T148860_1 - 2.8e-21 75.4 0.0 5.6e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein HEXIM PF15313.4 T148860_3 - 2.3e-53 180.1 3.9 2.3e-53 180.1 3.9 1.7 2 0 0 2 2 2 1 Hexamethylene bis-acetamide-inducible protein CATSPERG PF15064.4 T174854_1 - 2.7e-201 670.8 11.8 8.4e-145 483.8 0.4 3.0 3 0 0 3 3 3 3 Cation channel sperm-associated protein subunit gamma CATSPERG PF15064.4 T174854_2 - 1.9e-225 750.7 2.9 9e-211 702.2 2.8 3.0 3 0 0 3 3 3 3 Cation channel sperm-associated protein subunit gamma Glyco_transf_49 PF13896.4 T057904_1 - 6e-09 35.6 0.0 9.1e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glyco_transf_8 PF01501.18 T057904_1 - 2e-08 34.0 0.0 2.8e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 zf-H2C2_2 PF13465.4 T182398_2 - 8.8e-84 272.4 85.9 4e-09 36.4 0.7 15.5 14 1 1 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 T182398_2 - 1.2e-62 204.8 96.7 1.6e-05 25.0 1.2 15.3 15 0 0 15 15 14 14 Zinc finger, C2H2 type Ig_2 PF13895.4 T182398_2 - 3.9e-35 119.9 0.0 2.3e-14 53.3 0.0 6.5 6 0 0 6 6 6 5 Immunoglobulin domain zf-C2H2_4 PF13894.4 T182398_2 - 1.4e-29 100.0 104.8 0.0051 17.4 0.7 15.9 15 0 0 15 15 14 13 C2H2-type zinc finger Ig_3 PF13927.4 T182398_2 - 3.6e-14 53.0 0.0 0.014 15.8 0.0 4.8 4 0 0 4 4 4 3 Immunoglobulin domain zf-C2H2_6 PF13912.4 T182398_2 - 5.3e-09 35.7 76.9 0.021 14.6 0.2 14.1 14 0 0 14 14 14 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T182398_2 - 5.6e-09 36.0 29.4 0.63 10.3 0.0 10.8 12 0 0 12 12 12 4 Zinc-finger double-stranded RNA-binding ig PF00047.23 T182398_2 - 4.1e-06 26.7 0.0 0.72 9.9 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin domain Zn-ribbon_8 PF09723.8 T182398_2 - 7.8e-06 25.8 63.8 0.028 14.4 0.9 9.4 5 2 3 9 9 9 5 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T182398_2 - 0.011 16.3 36.6 1.6 9.4 0.3 7.2 3 3 4 7 7 7 0 zinc-ribbon family XPA_N PF01286.16 T182398_2 - 0.034 14.0 46.9 9.2 6.3 0.2 13.3 14 0 0 14 14 14 0 XPA protein N-terminal zf-LYAR PF08790.9 T182398_2 - 0.056 13.2 35.6 3.2 7.6 0.0 11.8 14 0 0 14 14 14 0 LYAR-type C2HC zinc finger DUF3268 PF11672.6 T182398_2 - 0.3 11.3 25.1 0.23 11.7 0.4 6.0 4 2 1 7 7 7 0 zinc-finger-containing domain ADK_lid PF05191.12 T182398_2 - 1.3 9.0 18.1 26 4.8 0.4 6.8 4 3 2 6 6 6 0 Adenylate kinase, active site lid HypA PF01155.17 T182398_2 - 1.7 8.5 40.0 1.9 8.4 1.5 7.0 1 1 5 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.5 T182398_2 - 3.6 7.5 61.2 1.6e+04 -41.1 60.3 7.8 1 1 0 1 1 0 0 Double zinc ribbon FYDLN_acid PF09538.8 T182398_2 - 4.4 7.9 21.5 63 4.2 0.3 8.1 3 3 5 8 8 8 0 Protein of unknown function (FYDLN_acid) zf-CCCH PF00642.22 T173926_1 - 0.011 15.5 0.5 0.034 13.9 0.5 1.9 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH PF00642.22 T173926_2 - 0.024 14.4 2.4 0.073 12.9 2.4 1.8 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.20 T173926_3 - 0.00061 19.4 0.0 0.00097 18.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1220 PF06758.11 T004087_1 - 3e-32 110.6 14.1 3.2e-16 59.2 2.5 2.9 2 0 0 2 2 2 2 Repeat of unknown function (DUF1220) GAT PF03127.12 T004087_1 - 2.2e-05 24.6 19.0 0.31 11.2 1.7 4.0 3 0 0 3 3 3 3 GAT domain DUF1258 PF06869.10 T004087_1 - 0.022 14.1 3.0 16 4.7 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1258) HIP1_clath_bdg PF16515.3 T004087_1 - 0.7 10.4 32.3 2.4 8.7 8.2 4.2 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MAP PF03642.11 T004087_1 - 4.3 7.7 9.5 2.9 8.2 0.3 3.1 4 0 0 4 4 4 0 MAP domain DUF1220 PF06758.11 T004087_2 - 5e-19 68.2 2.6 5e-19 68.2 2.6 3.1 3 0 0 3 3 3 1 Repeat of unknown function (DUF1220) DUF1220 PF06758.11 T004087_3 - 5.5e-89 292.3 33.5 6.2e-24 84.0 0.3 5.9 5 0 0 5 5 5 4 Repeat of unknown function (DUF1220) Ntox24 PF15529.4 T004087_3 - 0.038 14.2 0.7 13 6.1 0.1 2.3 2 0 0 2 2 2 0 Bacterial toxin 24 zinc_ribbon_16 PF17034.3 T318427_1 - 4.4e-23 81.7 14.2 9.5e-23 80.6 14.2 1.6 1 0 0 1 1 1 1 Zinc-ribbon like family JAB PF01398.19 T136130_2 - 9.5e-33 112.5 0.0 1.7e-32 111.7 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.4 T136130_2 - 5.2e-17 62.2 1.6 4.1e-09 36.8 0.2 2.4 1 1 1 2 2 2 2 Maintenance of mitochondrial structure and function GAGE PF05831.9 T136130_2 - 0.016 15.6 0.1 0.016 15.6 0.1 2.0 2 0 0 2 2 2 0 GAGE protein Connexin PF00029.17 T136130_2 - 0.027 14.1 0.8 0.043 13.4 0.8 1.2 1 0 0 1 1 1 0 Connexin BMF PF15185.4 T114692_3 - 1.3e-67 227.1 0.0 2.1e-67 226.5 0.0 1.3 1 0 0 1 1 1 1 Bcl-2-modifying factor, apoptosis HGWP PF03578.13 T152114_1 - 4 7.1 11.6 0.084 12.4 3.8 2.3 2 0 0 2 2 2 0 HGWP repeat Pkinase PF00069.23 T152114_2 - 1.4e-27 96.6 0.0 1.9e-27 96.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T152114_2 - 2.2e-21 76.2 0.0 3.3e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase LIM PF00412.20 T152114_2 - 2.6e-09 37.0 9.9 5.2e-09 36.1 9.9 1.5 1 0 0 1 1 1 1 LIM domain Zona_pellucida PF00100.21 T327063_1 - 5.4e-08 32.8 0.1 8.3e-08 32.2 0.1 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain POM121 PF15229.4 T327063_1 - 0.0018 17.9 0.1 0.0039 16.8 0.1 1.6 1 0 0 1 1 1 1 POM121 family MYCBPAP PF14646.4 T150473_1 - 2.7e-64 217.6 0.0 4e-64 217.0 0.0 1.2 1 0 0 1 1 1 1 MYCBP-associated protein family ENTH PF01417.18 T150473_1 - 2e-49 166.7 0.0 3.1e-49 166.0 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.14 T150473_1 - 0.00022 20.2 0.0 0.00033 19.6 0.0 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.17 T150473_1 - 0.048 13.4 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 VHS domain UIM PF02809.18 T150473_1 - 0.14 12.0 7.3 0.28 11.1 7.3 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif MYCBPAP PF14646.4 T150473_3 - 1.3e-53 182.4 9.5 4.2e-19 68.7 0.1 3.4 4 0 0 4 4 4 3 MYCBP-associated protein family Pkinase PF00069.23 T047125_2 - 2.9e-53 180.8 0.0 5.1e-53 180.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T047125_2 - 4.8e-37 127.5 0.0 7.7e-37 126.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Band_7 PF01145.23 T047125_2 - 3.1e-19 69.6 0.1 4.5e-19 69.0 0.1 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Kdo PF06293.12 T047125_2 - 0.0057 15.9 0.1 0.012 14.8 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4346 PF14251.4 T047125_2 - 0.38 10.7 2.3 0.81 9.6 2.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4346) IKKbetaNEMObind PF12179.6 T047125_3 - 8.3e-17 60.8 2.4 1.8e-16 59.7 2.4 1.6 1 0 0 1 1 1 1 I-kappa-kinase-beta NEMO binding domain DUF4653 PF15546.4 T007912_1 - 4.5e-117 390.1 0.8 7.2e-117 389.4 0.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4653) Ras PF00071.20 T166079_3 - 2.9e-46 156.9 0.2 4.2e-46 156.4 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T166079_3 - 8.8e-16 58.1 0.0 1.3e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF258 PF03193.14 T166079_3 - 3.4e-05 23.7 0.1 0.046 13.5 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Arf PF00025.19 T166079_3 - 5e-05 22.7 0.0 7.5e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.3 T166079_3 - 0.069 13.1 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.21 T166079_3 - 0.096 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Lipocalin PF00061.21 T369481_2 - 3.4e-07 30.4 0.0 0.0004 20.5 0.0 2.1 2 0 0 2 2 2 2 Lipocalin / cytosolic fatty-acid binding protein family Aldo_ket_red PF00248.19 T334148_1 - 2.6e-40 138.3 0.0 4.2e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family PI3_PI4_kinase PF00454.25 T099467_1 - 0.096 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase RhoGAP PF00620.25 T139325_2 - 1.9e-47 160.8 0.0 4.3e-47 159.6 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain RhoGEF PF00621.18 T139325_2 - 9.5e-32 110.6 2.3 1.6e-31 109.8 2.3 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 T139325_2 - 1.2e-09 38.5 4.2 3.8e-09 36.9 1.2 2.7 2 1 0 2 2 2 1 PH domain C2 PF00168.28 T139325_2 - 2.2e-06 27.8 0.1 4.3e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 C2 domain PH_10 PF15411.4 T139325_2 - 0.096 12.8 0.1 0.24 11.6 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Phage_antiter_Q PF06323.9 T139325_2 - 0.17 11.3 0.0 0.31 10.4 0.0 1.3 1 0 0 1 1 1 0 Phage antitermination protein Q Acyltransferase PF01553.19 T342872_2 - 2.2e-18 66.0 0.1 4.9e-18 64.9 0.1 1.6 1 0 0 1 1 1 1 Acyltransferase PITH PF06201.11 T162646_2 - 1.4e-39 135.6 0.1 1.9e-39 135.2 0.1 1.2 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.18 T162646_2 - 9.3e-16 57.5 0.0 1.6e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin SNF PF00209.16 T237968_3 - 2.4e-232 772.1 40.6 2.9e-232 771.9 40.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF2470 PF10615.7 T237968_3 - 0.13 12.7 0.2 0.25 11.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2470) PRKCSH_1 PF13015.4 T124940_2 - 3.9e-09 36.3 0.0 6.7e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.11 T124940_2 - 8.2e-08 33.0 1.6 1.6e-07 32.1 1.6 1.5 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein DMAP_binding PF06464.9 T124940_2 - 0.14 12.9 0.9 0.31 11.8 0.4 1.9 2 1 0 2 2 2 0 DMAP1-binding Domain DPM3 PF08285.9 T124940_2 - 0.2 11.7 0.0 0.39 10.8 0.0 1.4 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LRR_4 PF12799.5 T290198_1 - 2.6e-06 27.5 0.2 0.069 13.4 0.0 3.8 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T290198_1 - 7e-06 25.6 0.0 0.0065 16.1 0.0 3.4 3 0 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.31 T290198_1 - 0.077 13.4 5.5 39 5.2 0.1 5.0 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.4 T290198_1 - 0.093 12.7 7.2 3.8 7.7 0.0 4.1 5 0 0 5 5 5 0 Leucine Rich repeat 6PF2K PF01591.16 T375247_2 - 2.4e-65 219.8 0.7 3.7e-65 219.2 0.7 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 T375247_2 - 9.7e-42 142.7 0.0 1.3e-41 142.3 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 T375247_2 - 0.017 15.1 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.16 T375247_3 - 3.5e-15 55.8 0.1 4.8e-15 55.3 0.1 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Zeta_toxin PF06414.10 T375247_3 - 0.2 10.8 0.0 0.33 10.1 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Phtf-FEM1B_bdg PF12129.6 T017657_3 - 5.9e-69 230.7 3.3 1.3e-68 229.6 3.3 1.6 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor PRIMA1 PF16101.3 T017657_3 - 0.32 10.9 4.8 0.68 9.8 1.9 2.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 2-Hacid_dh_C PF02826.17 T050367_3 - 7.9e-54 181.5 0.0 1.1e-53 181.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 T050367_3 - 1.2e-27 96.1 0.0 1.6e-27 95.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 T050367_3 - 0.012 15.7 0.0 0.017 15.2 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Sulfotransfer_2 PF03567.12 T198736_2 - 1.1e-74 251.4 0.0 1.5e-74 250.9 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Gelsolin PF00626.20 T039127_1 - 7.6e-20 70.5 0.1 5e-05 23.0 0.0 5.6 5 0 0 5 5 5 4 Gelsolin repeat VHP PF02209.17 T039127_1 - 4.5e-16 58.5 0.3 2.9e-15 55.9 0.3 2.4 2 0 0 2 2 2 1 Villin headpiece domain DUF4695 PF15766.3 T039127_1 - 0.003 17.6 2.7 0.15 12.2 0.1 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF4695) NKAIN PF05640.12 T222254_1 - 1.1e-62 210.8 4.3 1.6e-62 210.3 4.3 1.2 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein FYRC PF05965.12 T069420_3 - 4e-18 65.2 0.0 8.5e-18 64.2 0.0 1.6 1 0 0 1 1 1 1 F/Y rich C-terminus FYRN PF05964.12 T069420_3 - 2.6e-17 62.3 0.7 5.2e-17 61.3 0.7 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus Innexin PF00876.16 T069420_3 - 4.6e-08 32.6 0.1 7.9e-08 31.8 0.1 1.3 1 0 0 1 1 1 1 Innexin Armet PF10208.7 T243070_1 - 8.5e-68 226.7 7.8 1.3e-67 226.1 7.8 1.3 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding SPOC PF07744.11 T243070_1 - 2.3e-36 124.9 0.0 4.7e-36 123.8 0.0 1.6 1 0 0 1 1 1 1 SPOC domain RRM_1 PF00076.20 T243070_1 - 2.4e-27 94.4 0.0 3e-13 49.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 T243070_1 - 0.0021 18.0 0.0 0.0075 16.2 0.0 1.8 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.4 T243070_1 - 0.086 12.7 0.1 2.1 8.2 0.0 2.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif REV PF00424.16 T243070_1 - 2.7 8.0 9.0 8.2 6.4 9.0 1.8 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) DHR-2 PF06920.11 T243070_3 - 2.3e-131 439.0 6.8 2.3e-131 439.0 6.8 1.7 2 0 0 2 2 2 1 Dock homology region 2 DOCK_N PF16172.3 T243070_3 - 4.5e-120 400.9 0.7 6.5e-120 400.4 0.7 1.2 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.4 T243070_3 - 1.9e-52 177.8 0.0 4.4e-52 176.6 0.0 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins SH3_2 PF07653.15 T243070_3 - 0.00013 21.5 0.2 0.0003 20.3 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain PLDc_2 PF13091.4 T155564_3 - 0.00012 21.8 0.0 0.00044 20.0 0.0 1.9 2 0 0 2 2 2 1 PLD-like domain cNMP_binding PF00027.27 T347285_2 - 2.1e-10 40.4 0.0 4.5e-06 26.5 0.0 3.3 3 1 0 3 3 3 2 Cyclic nucleotide-binding domain BTB PF00651.29 T260231_1 - 8.9e-25 86.9 2.1 1.4e-24 86.3 2.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 T260231_1 - 8.1e-06 25.9 1.0 3.6e-05 23.8 1.0 2.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type PyrI_C PF02748.13 T260231_1 - 0.00048 19.8 0.6 0.00098 18.9 0.6 1.5 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.6 T260231_1 - 0.004 17.3 0.3 0.011 15.9 0.3 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T260231_1 - 0.019 15.2 0.4 0.019 15.2 0.4 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 T260231_1 - 0.052 14.3 1.1 0.3 11.9 1.1 2.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T260231_2 - 6.6e-28 95.7 44.2 1.3e-08 34.7 2.7 6.7 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 T260231_2 - 2.6e-19 68.4 30.2 0.00057 20.1 1.3 7.0 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T260231_2 - 1.3e-06 28.5 53.0 0.023 15.4 1.2 8.1 8 0 0 8 8 8 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T260231_2 - 1e-05 25.2 5.1 0.00039 20.2 0.3 5.6 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T260231_2 - 0.0019 18.4 20.4 1.4 9.2 0.5 5.6 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.4 T260231_2 - 2.1 8.2 16.1 1.5 8.7 0.5 4.7 4 0 0 4 4 4 0 zinc-finger of a C2HC-type Surp PF01805.18 T170796_2 - 1.6e-15 56.7 0.2 7.1e-10 38.6 0.2 2.6 2 0 0 2 2 2 2 Surp module G-patch PF01585.21 T170796_2 - 9.6e-13 47.7 1.0 9.6e-13 47.7 1.0 2.4 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.5 T170796_2 - 0.083 12.9 0.1 0.26 11.3 0.1 1.8 1 0 0 1 1 1 0 G-patch domain DUF1041 PF06292.15 T170466_1 - 3.4e-36 123.6 0.3 6.8e-36 122.6 0.3 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) Membr_traf_MHD PF10540.7 T170466_1 - 8.7e-19 68.1 3.0 1.9e-18 67.0 3.0 1.6 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain Spc97_Spc98 PF04130.11 T170466_1 - 0.19 10.3 1.7 0.2 10.3 0.3 1.6 2 0 0 2 2 2 0 Spc97 / Spc98 family C2 PF00168.28 T170466_3 - 1.5e-38 131.1 2.7 1.8e-26 92.3 0.3 2.5 2 0 0 2 2 2 2 C2 domain C1_1 PF00130.20 T170466_3 - 2.2e-11 43.4 6.2 6.5e-11 41.8 6.2 1.9 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) APG6 PF04111.10 T170466_3 - 0.043 13.1 6.3 0.092 12.0 6.3 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1220 PF06758.11 T019232_3 - 1.1e-107 352.2 55.0 3.7e-25 87.9 3.9 6.2 6 0 0 6 6 6 5 Repeat of unknown function (DUF1220) EGF PF00008.25 T019232_3 - 1e-28 99.1 81.5 3e-07 30.5 5.3 7.3 6 0 0 6 6 6 6 EGF-like domain EGF_CA PF07645.13 T019232_3 - 7.4e-08 32.3 6.2 7.4e-08 32.3 6.2 6.7 3 1 3 6 6 6 1 Calcium-binding EGF domain hEGF PF12661.5 T019232_3 - 8e-06 26.2 90.7 1.4e-05 25.4 6.4 8.6 7 1 0 7 7 7 5 Human growth factor-like EGF GAT PF03127.12 T019232_3 - 0.00063 19.9 8.5 0.11 12.7 1.0 2.7 2 0 0 2 2 2 2 GAT domain FANCI_S3 PF14677.4 T019232_3 - 1.1 8.8 15.2 2.5 7.6 2.0 3.8 2 2 2 4 4 4 0 FANCI solenoid 3 PTR2 PF00854.19 T089362_1 - 3.4e-31 108.3 0.3 4.7e-31 107.9 0.3 1.1 1 0 0 1 1 1 1 POT family PTR2 PF00854.19 T089362_3 - 8e-62 209.2 3.4 1.1e-61 208.7 3.4 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.14 T089362_3 - 0.00063 18.6 4.3 0.00063 18.6 4.3 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.5 T089362_3 - 0.2 10.3 10.8 0.015 14.0 2.8 2.5 2 1 1 3 3 3 0 MFS_1 like family TPR_2 PF07719.15 T032711_1 - 1.2e-28 96.8 5.5 1.1e-05 25.0 0.4 7.6 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.26 T032711_1 - 1.9e-28 96.9 12.6 8.4e-08 31.6 0.4 8.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.4 T032711_1 - 3.8e-21 74.3 4.6 5.8e-05 22.6 0.0 7.2 3 1 4 7 7 7 6 TPR repeat TPR_8 PF13181.4 T032711_1 - 6.2e-18 63.3 5.0 0.00014 21.7 0.2 7.6 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_16 PF13432.4 T032711_1 - 7.7e-16 58.4 0.1 3.8e-05 24.2 0.0 4.2 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 T032711_1 - 1.3e-15 57.6 2.6 4.5e-05 23.7 0.2 5.3 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_9 PF13371.4 T032711_1 - 9e-15 54.5 2.3 0.00019 21.4 0.1 5.2 2 1 6 8 8 7 4 Tetratricopeptide repeat TPR_14 PF13428.4 T032711_1 - 1.1e-13 50.6 1.0 0.15 12.8 0.1 6.6 2 1 4 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.4 T032711_1 - 2.4e-13 50.0 6.9 2.4e-05 24.4 1.8 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.4 T032711_1 - 2.7e-09 36.7 0.5 1.8 9.0 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.4 T032711_1 - 0.00011 21.8 3.3 1 9.2 0.2 4.7 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.4 T032711_1 - 0.00014 21.5 2.5 0.022 14.6 0.2 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.5 T032711_1 - 0.00028 20.9 6.2 0.083 13.0 1.3 4.4 2 1 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.6 T032711_1 - 0.00037 19.4 0.9 0.068 11.9 0.2 2.2 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 BTAD PF03704.15 T032711_1 - 0.0039 17.5 0.8 1 9.7 0.0 2.7 1 1 0 2 2 2 1 Bacterial transcriptional activator domain SHNi-TPR PF10516.7 T032711_1 - 0.036 13.4 8.0 28 4.2 0.2 4.6 4 0 0 4 4 4 0 SHNi-TPR TPR_6 PF13174.4 T032711_1 - 0.16 12.5 5.9 29 5.5 0.1 5.4 7 0 0 7 7 5 0 Tetratricopeptide repeat Arfaptin PF06456.11 T054015_1 - 0.007 15.8 0.2 0.0087 15.5 0.2 1.1 1 0 0 1 1 1 1 Arfaptin-like domain Arfaptin PF06456.11 T054015_2 - 5.3e-70 235.4 1.4 6.9e-70 235.0 1.4 1.1 1 0 0 1 1 1 1 Arfaptin-like domain BAR PF03114.16 T054015_2 - 0.0019 17.8 1.2 0.003 17.1 1.2 1.2 1 0 0 1 1 1 1 BAR domain Peptidase_C54 PF03416.17 T012342_2 - 1.5e-102 342.4 0.0 2.1e-102 341.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 14-3-3 PF00244.18 T218413_1 - 1.7e-108 361.1 8.7 2.3e-108 360.7 8.7 1.2 1 0 0 1 1 1 1 14-3-3 protein RRM_1 PF00076.20 T218413_1 - 5.7e-72 237.4 0.1 8.3e-23 79.9 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 T218413_1 - 8.1e-05 22.1 0.7 0.1 12.1 0.2 3.2 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T218413_1 - 0.00044 20.2 0.0 0.89 9.6 0.0 3.6 3 0 0 3 3 3 1 RNA recognition motif Limkain-b1 PF11608.6 T218413_1 - 0.013 15.4 0.2 0.91 9.5 0.1 3.0 3 0 0 3 3 3 0 Limkain b1 PABP PF00658.16 T218413_3 - 4.1e-23 81.2 0.6 7e-23 80.5 0.6 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Hydrolase_6 PF13344.4 T228758_1 - 7.1e-18 64.5 0.0 1.1e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 T228758_2 - 9.4e-05 22.3 0.0 0.001 19.0 0.0 2.3 2 0 0 2 2 2 1 HAD-hyrolase-like PUF PF00806.17 T185697_3 - 2e-71 231.7 9.5 2.1e-09 36.4 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.9 T185697_3 - 0.097 12.9 1.3 9.3 6.4 0.1 3.5 1 1 2 3 3 3 0 CPL (NUC119) domain PC4 PF02229.14 T185697_3 - 0.17 11.4 0.5 0.38 10.3 0.5 1.5 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) DUF4510 PF14971.4 T111892_2 - 3.5e-72 241.8 12.1 3.5e-72 241.8 12.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4510) DUF4509 PF14970.4 T111892_2 - 2.1e-54 184.2 0.0 3.1e-54 183.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4509) LIM PF00412.20 T111892_3 - 1.3e-37 127.7 33.9 3.1e-13 49.6 6.6 3.5 3 0 0 3 3 3 3 LIM domain APG9 PF04109.14 T208038_1 - 1.9e-130 435.2 0.4 2.8e-130 434.7 0.4 1.2 1 0 0 1 1 1 1 Autophagy protein Apg9 MTABC_N PF16185.3 T208038_1 - 4.1e-76 255.6 0.1 7.6e-76 254.7 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region PRRSV_2b PF07069.9 T208038_1 - 0.096 13.1 1.1 0.3 11.5 1.1 1.8 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b ABC_tran PF00005.25 T208038_3 - 3.3e-34 118.2 0.0 4.7e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.21 T208038_3 - 2.1e-18 66.8 8.0 2.8e-18 66.4 8.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.17 T208038_3 - 2e-06 27.3 0.1 3e-05 23.4 0.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 T208038_3 - 0.0021 18.3 0.0 0.004 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 T208038_3 - 0.0024 17.6 0.0 0.0045 16.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 T208038_3 - 0.0068 16.0 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.4 T208038_3 - 0.011 15.9 0.0 0.028 14.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.4 T208038_3 - 0.034 13.8 0.0 0.061 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.27 T208038_3 - 0.066 13.5 0.0 0.41 10.9 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.4 T208038_3 - 0.27 10.8 0.0 0.44 10.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF3413 PF11893.6 T208038_3 - 0.73 8.8 4.6 1.3 8.0 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) DUF1725 PF08333.9 T290990_2 - 3.5e-09 35.9 0.8 6.9e-09 35.0 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Kazal_2 PF07648.13 T290990_3 - 7.9e-136 441.9 98.5 6.8e-11 42.0 4.5 15.5 15 0 0 15 15 15 15 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 T290990_3 - 8.5e-91 297.7 112.1 6e-14 51.7 5.1 15.3 15 0 0 15 15 15 14 Kazal-type serine protease inhibitor domain zf-RING_2 PF13639.4 T225852_1 - 6.8e-10 38.9 6.0 1.9e-09 37.5 6.0 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 T225852_1 - 1.5e-07 31.0 6.2 4.3e-07 29.5 6.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T225852_1 - 8.6e-07 28.6 6.3 2.2e-06 27.3 6.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 T225852_1 - 2.6e-06 27.5 5.9 7.4e-06 26.0 5.9 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 T225852_1 - 9.2e-05 22.2 7.2 0.00023 20.9 7.2 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 T225852_1 - 0.00023 21.0 4.0 0.00061 19.6 4.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 T225852_1 - 0.00027 20.6 4.3 0.00027 20.6 4.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 T225852_1 - 0.0018 17.8 4.3 0.006 16.1 4.3 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.5 T225852_1 - 0.17 11.9 1.8 0.41 10.6 1.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PAM2 PF07145.13 T225852_1 - 0.21 11.3 1.5 0.55 9.9 0.0 2.4 2 0 0 2 2 2 0 Ataxin-2 C-terminal region FANCL_C PF11793.6 T225852_1 - 0.35 11.0 3.7 0.79 9.8 3.7 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.4 T225852_1 - 0.76 9.6 5.9 2.4 8.0 5.9 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.9 T225852_1 - 4.6 7.5 8.3 12 6.1 8.3 1.8 1 0 0 1 1 1 0 RING-like domain TPR_1 PF00515.26 T225852_3 - 8.7e-09 34.7 16.1 0.0022 17.6 0.4 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.15 T225852_3 - 1.4e-07 30.9 11.2 0.0099 15.8 0.2 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.4 T225852_3 - 0.00019 21.2 1.0 1.2 9.4 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.4 T225852_3 - 0.00022 21.3 0.8 0.071 13.3 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.4 T225852_3 - 0.00033 20.7 0.7 0.0081 16.4 0.2 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.4 T225852_3 - 0.00062 19.3 2.0 0.084 12.4 0.1 3.2 3 0 0 3 3 3 1 TPR repeat TPR_16 PF13432.4 T225852_3 - 0.0022 18.5 4.8 0.11 13.1 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.5 T225852_3 - 0.0022 18.0 1.1 0.0058 16.7 0.2 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.4 T225852_3 - 0.15 12.1 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat SH3_9 PF14604.4 T046549_2 - 4.8e-37 125.4 0.6 2.3e-14 52.8 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 T046549_2 - 1.5e-35 120.4 0.4 2.4e-10 39.7 0.0 3.5 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 T046549_2 - 2.1e-28 97.6 0.2 6.3e-12 44.9 0.0 3.5 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 T046549_2 - 4.9e-23 80.4 1.3 9.5e-23 79.5 1.3 1.5 1 0 0 1 1 1 1 Sorbin homologous domain IBR PF01485.19 T242327_2 - 1.3e-16 60.4 32.1 1.3e-12 47.6 6.2 4.5 5 0 0 5 5 5 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.4 T242327_2 - 0.8 9.5 41.9 0.0065 16.2 9.4 4.1 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF3715 PF12509.6 T243954_3 - 1.5e-53 180.7 0.0 3.1e-53 179.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3715) ETAA1 PF15350.4 T190995_2 - 1.1e-69 235.6 3.5 1.4e-69 235.2 3.5 1.1 1 0 0 1 1 1 1 Ewing's tumour-associated antigen 1 homologue ETAA1 PF15350.4 T190995_3 - 2.4e-55 188.1 19.4 3.1e-55 187.8 19.4 1.0 1 0 0 1 1 1 1 Ewing's tumour-associated antigen 1 homologue Beach PF02138.16 T272805_1 - 4.8e-125 416.4 0.8 7.2e-125 415.8 0.8 1.3 1 0 0 1 1 1 1 Beige/BEACH domain DUF4704 PF15787.3 T272805_1 - 1.1e-105 352.8 6.9 1.1e-105 352.8 6.9 2.6 1 1 2 3 3 3 1 Domain of unknown function (DUF4704) DUF1088 PF06469.9 T272805_1 - 9.9e-86 285.5 3.2 2.1e-85 284.5 3.2 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) PH_BEACH PF14844.4 T272805_1 - 3.8e-29 100.6 0.3 1e-27 96.0 0.0 2.8 3 0 0 3 3 3 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.4 T272805_1 - 2.3e-11 43.9 0.0 1.3e-10 41.5 0.0 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.30 T272805_1 - 8.1e-08 32.7 1.8 1.1 10.1 0.2 6.2 5 0 0 5 5 5 2 WD domain, G-beta repeat RNase_Zc3h12a PF11977.6 T375638_3 - 1.9e-63 212.7 0.0 2.9e-63 212.2 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain Acetyltransf_13 PF13880.4 T341007_1 - 1.2e-27 95.5 0.0 2.2e-27 94.7 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.4 T341007_1 - 4.6e-15 55.0 1.7 1.1e-14 53.8 1.7 1.7 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Ion_trans PF00520.29 T114053_2 - 1.7e-14 53.5 3.4 2.6e-14 52.9 3.4 1.2 1 0 0 1 1 1 1 Ion transport protein RR_TM4-6 PF06459.10 T114053_3 - 5.7e-59 200.1 20.0 6.6e-32 111.3 7.4 2.9 2 1 1 3 3 3 2 Ryanodine Receptor TM 4-6 EF-hand_1 PF00036.30 T114053_3 - 2.6e-05 23.3 0.1 6.8e-05 22.0 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.4 T114053_3 - 0.0003 20.4 0.1 0.0013 18.4 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 T114053_3 - 0.00064 19.3 1.9 0.0012 18.5 0.6 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.4 T114053_3 - 0.0048 17.2 1.1 0.0048 17.2 1.1 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.4 T114053_3 - 0.017 14.5 0.0 0.034 13.5 0.0 1.5 1 0 0 1 1 1 0 EF hand Homeobox_KN PF05920.9 T277815_2 - 2e-15 56.2 0.4 3.8e-15 55.4 0.4 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 T277815_2 - 8.7e-07 28.5 2.3 1.5e-06 27.8 2.3 1.3 1 0 0 1 1 1 1 Homeobox domain MRP-S32 PF10210.7 T277815_2 - 0.15 12.5 0.6 0.32 11.5 0.6 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 Med16 PF11635.6 T165373_2 - 8.2e-121 404.2 0.0 1.2e-120 403.7 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 16 WD40 PF00400.30 T165373_2 - 0.00079 20.1 0.8 0.0044 17.7 0.8 2.4 1 0 0 1 1 1 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T165373_2 - 0.012 15.8 0.0 0.17 12.1 0.1 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain CLAMP PF14769.4 T130437_2 - 3.7e-05 24.0 0.0 6.1e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 CLAMP PF14769.4 T130437_3 - 7.3e-18 64.7 0.1 1.8e-13 50.6 0.2 2.3 2 0 0 2 2 2 2 Flagellar C1a complex subunit C1a-32 SCAN PF02023.15 T140243_1 - 7.5e-41 137.7 3.0 1.2e-40 137.1 3.0 1.3 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 T140243_2 - 1.8e-33 113.3 33.8 3.2e-08 33.5 0.4 6.3 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 T140243_2 - 5e-26 89.5 29.4 9.9e-07 28.8 1.0 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T140243_2 - 3.5e-12 45.9 30.4 0.0052 17.4 0.7 5.8 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T140243_2 - 3.1e-09 36.4 24.3 0.2 11.5 0.7 5.7 5 0 0 5 5 5 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T140243_2 - 0.00017 21.5 19.4 0.017 15.1 2.9 3.7 2 1 1 3 3 3 3 Zinc ribbon domain XPA_N PF01286.16 T140243_2 - 0.004 17.0 21.8 0.27 11.2 0.4 5.4 5 0 0 5 5 5 2 XPA protein N-terminal zf-trcl PF13451.4 T140243_2 - 0.028 14.2 16.4 11 5.8 0.1 5.3 5 0 0 5 5 5 0 Probable zinc-ribbon domain DZR PF12773.5 T140243_2 - 0.17 11.8 15.2 1.2 9.1 5.2 3.2 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_15 PF17032.3 T140243_2 - 0.26 11.9 14.7 3.6 8.3 1.5 3.0 1 1 2 3 3 3 0 zinc-ribbon family HypA PF01155.17 T140243_2 - 0.38 10.6 12.1 6.2 6.7 1.1 3.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_jaz PF12171.6 T140243_2 - 0.6 10.4 16.8 3.3 8.0 0.1 5.1 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 T140243_2 - 0.6 10.3 10.3 0.39 10.9 0.6 2.8 2 1 1 3 3 3 0 zinc-finger-containing domain zf-C2H2_11 PF16622.3 T140243_2 - 2.3 7.9 18.1 0.22 11.2 0.3 5.0 5 0 0 5 5 5 0 zinc-finger C2H2-type YhfH PF14149.4 T140243_2 - 2.4 8.1 17.0 29 4.6 0.1 5.3 5 0 0 5 5 5 0 YhfH-like protein ADK_lid PF05191.12 T140243_2 - 2.5 8.1 11.4 5.7 6.9 1.7 3.8 2 1 0 2 2 2 0 Adenylate kinase, active site lid LIM PF00412.20 T140243_2 - 2.9 8.0 13.2 7.7 6.7 1.2 4.0 1 1 1 3 3 3 0 LIM domain DUF2321 PF10083.7 T140243_2 - 3 7.3 11.5 1.4 8.4 1.6 2.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-LYAR PF08790.9 T140243_2 - 4.3 7.2 14.9 0.97 9.3 0.3 4.3 5 0 0 5 5 4 0 LYAR-type C2HC zinc finger CpXC PF14353.4 T140243_2 - 7.4 6.5 10.8 10 6.1 0.0 4.1 2 1 2 4 4 4 0 CpXC protein Tmemb_cc2 PF10267.7 T250421_3 - 5.6e-166 552.4 13.7 1.2e-165 551.4 13.7 1.6 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein ATF7IP_BD PF16788.3 T250421_3 - 0.0089 16.2 2.4 0.0089 16.2 2.4 2.3 2 0 0 2 2 2 1 ATF-interacting protein binding domain UPF0565 PF10561.7 T250421_3 - 8.3 5.4 8.3 0.23 10.5 0.4 2.1 2 1 0 2 2 2 0 Uncharacterised protein family UPF0565 Myosin_head PF00063.19 T170285_1 - 5.1e-214 712.3 15.1 4.3e-182 606.7 3.0 2.4 3 0 0 3 3 3 2 Myosin head (motor domain) RhoGAP PF00620.25 T170285_1 - 9e-46 155.3 0.3 2.9e-45 153.7 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain RA PF00788.21 T170285_1 - 2.3e-18 66.5 4.1 7e-16 58.5 0.0 3.9 3 0 0 3 3 3 2 Ras association (RalGDS/AF-6) domain IQ PF00612.25 T170285_1 - 1.2e-15 55.6 27.8 0.00045 19.6 2.2 6.0 5 0 0 5 5 5 4 IQ calmodulin-binding motif C1_1 PF00130.20 T170285_1 - 6.9e-05 22.5 11.4 0.00014 21.5 11.4 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RGM_N PF06535.10 T170285_1 - 0.08 13.1 3.1 0.069 13.3 0.4 2.3 2 0 0 2 2 2 0 Repulsive guidance molecule (RGM) N-terminus AAA_22 PF13401.4 T170285_1 - 0.11 12.6 0.1 0.43 10.7 0.1 2.0 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.18 T170285_1 - 0.12 11.3 0.0 0.22 10.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.4 T170285_1 - 0.71 10.1 3.2 1.2 9.4 0.0 3.1 3 0 0 3 3 3 0 AAA ATPase domain Zf_RING PF16744.3 T170285_1 - 0.83 9.7 7.4 2.2 8.3 7.4 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger zf-RING_9 PF13901.4 T170285_1 - 2.5 7.9 11.4 0.12 12.2 4.3 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Use1 PF09753.7 T170285_3 - 5.5e-92 307.8 8.4 7.2e-92 307.4 8.4 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 MCU PF04678.11 T170285_3 - 0.0069 16.4 1.2 0.011 15.7 1.2 1.3 1 0 0 1 1 1 1 Mitochondrial calcium uniporter Prominin PF05478.9 T170285_3 - 0.039 11.8 0.4 0.054 11.3 0.4 1.0 1 0 0 1 1 1 0 Prominin Peptidase_M56 PF05569.9 T170285_3 - 0.17 10.9 0.4 0.25 10.4 0.4 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 Ank_2 PF12796.5 T233535_1 - 5.9e-33 113.2 13.5 5.5e-09 36.4 0.2 4.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T233535_1 - 2.4e-29 101.2 1.3 1.5e-06 28.5 0.1 6.9 6 1 1 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.28 T233535_1 - 6.2e-26 89.5 6.8 0.00013 22.1 0.0 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.4 T233535_1 - 5.5e-25 86.9 6.1 1.9e-10 40.7 1.0 5.8 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.4 T233535_1 - 5.3e-21 72.3 4.3 0.0015 18.8 0.0 7.0 6 0 0 6 6 6 4 Ankyrin repeat SH3_9 PF14604.4 T233535_1 - 7.2e-05 22.4 0.0 0.00025 20.7 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain IMD PF08397.9 T233535_2 - 4.5e-83 277.8 7.6 9.6e-81 270.2 5.8 2.1 2 0 0 2 2 2 2 IRSp53/MIM homology domain Patatin PF01734.20 T233535_2 - 4.9e-16 59.4 0.6 1.5e-15 57.8 0.6 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase MFS_1 PF07690.14 T233535_2 - 7.2e-16 57.9 11.4 1.1e-15 57.2 11.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily BAR_3 PF16746.3 T233535_2 - 0.00051 19.7 7.2 0.00073 19.2 7.2 1.1 1 0 0 1 1 1 1 BAR domain of APPL family Golgin_A5 PF09787.7 T233535_2 - 1.3 8.3 7.3 2 7.7 7.3 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Transmemb_17 PF09799.7 T190345_3 - 3.6e-29 101.3 14.5 3.6e-29 101.3 14.5 2.2 2 0 0 2 2 2 1 Predicted membrane protein DUF3043 PF11241.6 T190345_3 - 1.1 9.1 7.3 4.7 7.1 1.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3043) Zfx_Zfy_act PF04704.11 T372464_1 - 1.7e-152 507.1 18.3 2.4e-152 506.6 18.3 1.2 1 0 0 1 1 1 1 Zfx / Zfy transcription activation region zf-C2H2 PF00096.24 T372464_1 - 1.4e-34 116.5 113.5 4.2e-05 23.6 2.1 14.4 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T372464_1 - 1.3e-28 98.0 122.7 1.4e-07 31.5 1.2 14.7 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2_4 PF13894.4 T372464_1 - 2e-23 80.9 108.8 0.00057 20.4 0.9 15.0 13 0 0 13 13 13 11 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T372464_1 - 3.4e-19 68.1 105.0 1.8e-06 27.5 5.8 11.8 12 0 0 12 12 12 8 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 T372464_1 - 2.6e-07 30.6 68.7 0.14 12.4 0.1 11.9 12 0 0 12 12 12 6 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T372464_1 - 0.00038 21.0 47.0 0.15 12.7 2.2 7.9 5 1 2 7 7 7 4 zinc-ribbon family zf-C2H2_11 PF16622.3 T372464_1 - 0.0079 15.8 56.6 0.084 12.5 0.3 9.4 9 0 0 9 9 9 5 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 T372464_1 - 0.11 12.4 57.3 0.058 13.2 3.1 9.1 8 0 0 8 8 8 0 C2H2-type zinc finger zf-met PF12874.5 T372464_1 - 0.68 10.3 60.0 1.5 9.2 0.0 11.2 10 1 0 10 10 10 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.24 T375379_2 - 7.3e-12 44.9 24.4 0.00021 21.4 5.5 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T375379_2 - 1.8e-08 34.3 20.6 4.1e-06 26.8 1.8 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 T375379_2 - 0.053 14.2 30.8 0.061 14.1 3.0 4.9 4 0 0 4 4 4 0 C2H2-type zinc finger HSP70 PF00012.18 T105895_1 - 6.5e-190 632.2 10.3 2e-180 600.8 5.9 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.11 T105895_1 - 9e-12 44.3 0.1 7.6e-11 41.3 0.0 1.9 1 1 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 T105895_1 - 0.0019 18.5 3.0 2.9 8.2 0.0 3.3 3 0 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 T105895_1 - 0.0019 17.8 0.0 0.0041 16.7 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain ARA70 PF12489.6 T105895_1 - 0.023 14.7 0.0 0.023 14.7 0.0 2.3 3 0 0 3 3 3 0 Nuclear coactivator DUF1464 PF07318.10 T105895_1 - 0.15 11.1 0.0 0.27 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) Hydantoinase_A PF01968.16 T105895_1 - 0.17 10.9 0.4 0.83 8.7 0.1 1.9 1 1 1 2 2 2 0 Hydantoinase/oxoprolinase WD40 PF00400.30 T001008_2 - 1.2e-40 136.6 21.4 6.1e-08 33.1 0.0 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T001008_2 - 5.2e-14 52.2 0.0 0.0014 18.7 0.0 5.4 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 T001008_2 - 0.00028 20.2 0.0 0.0017 17.6 0.0 2.0 1 1 1 2 2 2 1 WD40-like domain eIF2A PF08662.9 T001008_2 - 0.00097 18.9 0.0 1.3 8.8 0.0 2.6 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Myc-LZ PF02344.13 T001008_2 - 0.12 12.4 1.2 0.24 11.4 1.2 1.4 1 0 0 1 1 1 0 Myc leucine zipper domain CALM_bind PF16025.3 T001008_2 - 0.15 12.4 1.5 0.34 11.2 1.5 1.5 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Acetyltransf_1 PF00583.23 T330036_1 - 0.013 15.6 0.0 0.025 14.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family KCNQ_channel PF03520.12 T306554_2 - 4.1e-94 313.6 1.6 6.4e-94 313.0 1.6 1.3 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel Ion_trans PF00520.29 T306554_2 - 2.2e-15 56.4 1.7 4.1e-15 55.5 1.7 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 T306554_2 - 4.8e-14 52.0 5.3 9.4e-14 51.0 5.3 1.5 1 0 0 1 1 1 1 Ion channel NDK PF00334.17 T251240_2 - 1.3e-38 131.9 0.0 4.4e-38 130.2 0.0 1.7 2 0 0 2 2 2 1 Nucleoside diphosphate kinase Thioredoxin PF00085.18 T251240_2 - 2.2e-06 27.4 0.0 3.7e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin RVT_1 PF00078.25 T347509_2 - 1.3e-12 47.6 2.6 2.3e-12 46.8 2.6 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pyr_redox_3 PF13738.4 T347509_2 - 5.5e-05 22.4 0.0 0.0031 16.7 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Transposase_22 PF02994.12 T347509_3 - 2.3e-19 69.4 3.5 3.5e-19 68.8 3.5 1.2 1 0 0 1 1 1 1 L1 transposable element Arm PF00514.21 T038883_2 - 2.4e-52 173.4 24.0 3.9e-06 26.6 0.0 13.6 13 0 0 13 13 13 12 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 T038883_2 - 3.9e-20 71.9 5.5 1.5e-05 25.2 0.0 7.3 4 2 2 7 7 7 4 HEAT repeats HEAT_EZ PF13513.4 T038883_2 - 2.1e-11 43.9 8.9 0.0019 18.5 0.3 8.3 7 3 3 10 10 10 3 HEAT-like repeat HEAT PF02985.20 T038883_2 - 1.4e-09 37.2 14.2 0.6 10.4 0.1 9.1 9 0 0 9 9 9 3 HEAT repeat Adaptin_N PF01602.18 T038883_2 - 1.2e-08 33.9 7.9 2e-05 23.2 0.2 3.8 2 1 1 3 3 3 2 Adaptin N terminal region KAP PF05804.10 T038883_2 - 3.8e-08 31.9 3.1 0.0068 14.5 0.1 3.2 2 1 1 3 3 3 3 Kinesin-associated protein (KAP) Arm_2 PF04826.11 T038883_2 - 6.4e-08 32.2 12.5 0.029 13.7 0.1 6.7 3 2 3 7 7 7 3 Armadillo-like Cnd1 PF12717.5 T038883_2 - 7.7e-08 32.4 5.6 0.036 13.9 0.1 4.8 2 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.6 T038883_2 - 2.1e-07 30.9 12.2 1.8 8.6 0.5 7.4 5 3 2 8 8 8 3 V-ATPase subunit H UNC45-central PF11701.6 T038883_2 - 4.3e-07 29.9 3.0 0.24 11.2 0.1 4.6 3 1 1 4 4 4 2 Myosin-binding striated muscle assembly central DUF727 PF05303.10 T038883_2 - 0.0028 17.5 0.0 0.0098 15.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF727) V-ATPase_H_N PF03224.12 T038883_2 - 0.004 16.4 0.5 3 6.9 0.1 3.5 2 1 0 2 2 2 1 V-ATPase subunit H RasGEF_N_2 PF14663.4 T038883_2 - 0.0082 16.3 14.5 6.6 7.0 0.0 6.8 6 1 2 8 8 7 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Vac14_Fab1_bd PF12755.5 T038883_2 - 0.022 15.2 0.1 23 5.5 0.0 4.2 5 0 0 5 5 4 0 Vacuolar 14 Fab1-binding region RTTN_N PF14726.4 T038883_2 - 0.17 12.6 1.4 55 4.6 0.1 4.7 3 2 2 5 5 5 0 Rotatin, an armadillo repeat protein, centriole functioning Defensin_3 PF08131.9 T017523_2 - 1.8 8.7 4.2 11 6.2 0.0 2.6 2 0 0 2 2 2 0 Defensin-like peptide family ST7 PF04184.10 T017523_3 - 9.8e-42 142.9 0.0 1.3e-41 142.5 0.0 1.1 1 0 0 1 1 1 1 ST7 protein PH PF00169.27 T199340_1 - 2.6e-08 34.2 0.0 4.5e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 PH domain RhoGEF PF00621.18 T199340_3 - 3.2e-39 134.9 2.4 4.5e-39 134.4 2.4 1.1 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 T199340_3 - 1.9e-10 40.0 1.9 3.4e-10 39.2 1.9 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 T199340_3 - 1.8e-08 33.8 0.0 3.6e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T199340_3 - 1.9e-07 30.7 0.2 3.2e-07 29.9 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain MIP PF00230.18 T129152_1 - 0.0049 16.5 0.0 0.0076 15.9 0.0 1.2 1 0 0 1 1 1 1 Major intrinsic protein MIP PF00230.18 T129152_3 - 9.4e-40 136.6 7.5 1.3e-39 136.1 7.5 1.2 1 0 0 1 1 1 1 Major intrinsic protein DNMT1-RFD PF12047.6 T168195_1 - 9e-48 161.8 0.0 1.5e-46 157.9 0.0 2.6 2 0 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain DNA_methylase PF00145.15 T168195_1 - 4.9e-47 160.8 0.0 4.9e-47 160.8 0.0 3.2 2 2 0 2 2 2 1 C-5 cytosine-specific DNA methylase BAH PF01426.16 T168195_1 - 6.5e-46 155.0 0.0 1.1e-21 76.8 0.0 2.6 2 0 0 2 2 2 2 BAH domain DMAP_binding PF06464.9 T168195_1 - 9.5e-21 74.6 2.9 9.5e-21 74.6 2.9 3.5 2 1 1 3 3 3 1 DMAP1-binding Domain zf-CXXC PF02008.18 T168195_1 - 6.2e-15 54.8 21.5 1.9e-14 53.3 21.5 1.9 1 0 0 1 1 1 1 CXXC zinc finger domain HTH_12 PF08461.8 T168195_1 - 0.11 12.4 0.1 0.26 11.1 0.1 1.6 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain DUF4764 PF15961.3 T370794_1 - 1.2e-94 318.4 7.4 2.3e-89 301.0 1.4 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4764) DUF4764 PF15961.3 T370794_2 - 7e-07 28.2 1.3 9.5e-07 27.8 1.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) DUF1725 PF08333.9 T370794_2 - 0.0011 18.4 5.0 0.0019 17.6 5.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF4764 PF15961.3 T370794_3 - 1.9e-11 43.3 0.2 2.6e-11 42.8 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) Vinculin PF01044.17 T043047_3 - 2.2e-57 194.9 9.0 5.1e-43 147.4 2.4 2.5 2 1 0 2 2 2 2 Vinculin family Neur_chan_LBD PF02931.21 T140987_2 - 4.7e-63 212.4 0.0 6.3e-63 212.0 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 T140987_2 - 3.2e-52 177.8 0.0 5.7e-52 177.0 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region FGF PF00167.16 T140987_2 - 1.3e-14 54.2 0.0 2.1e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Mab-21 PF03281.12 T140987_2 - 3.5e-08 33.0 0.0 6.1e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Mab-21 protein Fascin PF06268.11 T140987_2 - 0.025 14.7 0.0 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 Fascin domain Neur_chan_memb PF02932.14 T140987_3 - 1.8e-15 57.5 0.0 2.9e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Spectrin PF00435.19 T008523_3 - 1.1e-209 681.4 434.5 2e-17 63.4 4.8 42.2 38 5 2 41 41 40 34 Spectrin repeat TGFb_propeptide PF00688.16 T008523_3 - 4.4e-63 213.2 0.0 1.4e-62 211.5 0.0 2.0 1 0 0 1 1 1 1 TGF-beta propeptide CH PF00307.29 T008523_3 - 1.5e-45 153.7 0.5 1.5e-21 76.5 0.5 3.8 2 0 0 2 2 2 2 Calponin homology (CH) domain TGF_beta PF00019.18 T008523_3 - 7.6e-35 119.8 2.7 3.5e-34 117.7 2.7 2.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain GAS2 PF02187.15 T008523_3 - 1.3e-30 105.2 0.3 3.3e-30 103.8 0.3 1.8 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_1 PF00036.30 T008523_3 - 4.4e-11 41.4 2.2 0.00018 20.7 0.7 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 T008523_3 - 2.4e-10 40.6 0.9 1.2e-09 38.3 0.9 2.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T008523_3 - 4.7e-10 38.4 1.6 0.00092 18.8 0.4 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 T008523_3 - 6.6e-08 32.1 0.1 3.2e-07 29.9 0.1 2.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 T008523_3 - 2.9e-07 29.6 4.1 5.2e-05 22.4 1.4 2.7 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.6 T008523_3 - 4.2e-05 23.2 0.1 0.0094 15.6 0.0 2.9 2 0 0 2 2 2 1 CAMSAP CH domain CcdA PF07362.10 T008523_3 - 1 9.7 5.2 2 8.8 1.6 3.6 2 0 0 2 2 2 0 Post-segregation antitoxin CcdA DUF19 PF01579.16 T008523_3 - 1.8 8.2 13.4 0.015 15.0 2.1 3.4 2 0 0 2 2 1 0 Domain of unknown function (DUF19) DASH_Dam1 PF08653.8 T008523_3 - 3.3 7.5 14.6 9 6.0 0.1 6.8 6 0 0 6 6 5 0 DASH complex subunit Dam1 SCAN PF02023.15 T160793_1 - 2.9e-41 139.1 5.5 4.9e-41 138.3 5.5 1.4 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 T160793_2 - 1.2e-60 199.3 47.8 5.5e-08 32.8 0.4 10.9 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 T160793_2 - 1.1e-54 179.8 59.4 1.1e-06 28.6 0.6 10.1 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T160793_2 - 7.7e-25 85.3 57.6 0.0051 17.4 0.6 10.1 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T160793_2 - 7.7e-15 54.3 49.1 0.0098 15.7 0.2 9.6 9 0 0 9 9 9 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T160793_2 - 1.9e-11 43.7 40.3 0.0096 15.9 3.2 6.1 3 2 1 5 5 5 5 Zinc ribbon domain XPA_N PF01286.16 T160793_2 - 4.6e-07 29.6 32.8 2.4 8.1 0.7 9.3 9 0 0 9 9 9 4 XPA protein N-terminal zinc_ribbon_15 PF17032.3 T160793_2 - 0.00027 21.5 35.7 0.57 10.8 1.2 5.3 1 1 6 7 7 7 7 zinc-ribbon family zf-C2H2_jaz PF12171.6 T160793_2 - 0.001 19.2 27.8 0.25 11.6 0.1 8.1 8 0 0 8 8 8 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T160793_2 - 0.0087 15.7 44.5 1.5 8.5 0.1 9.1 9 0 0 9 9 9 5 zinc-finger C2H2-type DZR PF12773.5 T160793_2 - 0.0087 15.9 37.1 7.6 6.5 5.7 5.3 1 1 2 3 3 3 1 Double zinc ribbon C1_4 PF07975.10 T160793_2 - 0.88 9.7 34.3 0.63 10.2 2.2 5.8 2 1 3 6 6 6 0 TFIIH C1-like domain HypA PF01155.17 T160793_2 - 5.4 6.9 32.3 12 5.8 1.6 5.0 1 1 5 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.6 T160793_2 - 6.8 6.9 26.2 3.1 8.0 1.5 4.8 4 1 1 5 5 5 0 zinc-finger-containing domain Brix PF04427.16 T199174_1 - 6.9e-28 97.9 0.0 9.6e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Brix domain Y_phosphatase PF00102.25 T199174_2 - 1.2e-38 132.8 0.1 1.8e-38 132.3 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 T199174_2 - 0.026 14.4 0.0 0.04 13.7 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family MFS_1 PF07690.14 T299002_1 - 4.1e-05 22.5 0.6 6.9e-05 21.8 0.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Eapp_C PF10238.7 T299002_1 - 5.5 6.9 8.7 9.8 6.1 8.7 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Enolase_C PF00113.20 T140126_1 - 2.6e-153 509.4 0.0 3.3e-153 509.0 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.14 T140126_1 - 5e-59 198.0 0.0 7.9e-59 197.4 0.0 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.4 T140126_1 - 1.9e-06 27.6 0.0 3.4e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.9 T140126_1 - 7.8e-05 21.8 0.4 0.00013 21.1 0.4 1.3 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus FAM153 PF15722.3 T293943_2 - 2.5e-108 356.4 22.2 1.6e-41 141.1 6.3 4.3 2 1 2 4 4 4 4 FAM153 family Peptidase_C1 PF00112.21 T020597_3 - 1.3e-81 273.8 3.7 1.8e-81 273.3 3.7 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 T020597_3 - 5e-12 45.9 0.4 1.1e-11 44.9 0.4 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 T020597_3 - 0.0025 16.5 1.4 0.079 11.6 0.4 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Phosducin PF02114.14 T265015_1 - 1.1e-16 60.5 1.6 2e-16 59.6 1.6 1.3 1 1 0 1 1 1 1 Phosducin DUF3886 PF13025.4 T265015_1 - 0.14 12.2 6.6 0.31 11.1 6.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) FXMRP1_C_core PF12235.6 T141063_2 - 1.8e-33 115.9 8.5 1.8e-33 115.9 8.5 3.5 2 1 2 4 4 4 1 Fragile X-related 1 protein core C terminal FXR_C1 PF16096.3 T141063_2 - 1.6e-32 111.4 3.2 1.6e-32 111.4 3.2 3.3 3 1 1 4 4 4 1 Fragile X-related 1 protein C-terminal region 2 HMG_box PF00505.17 T141063_2 - 4.2e-26 91.0 2.6 7.2e-26 90.3 2.6 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box KH_1 PF00013.27 T141063_2 - 1e-17 63.6 0.8 6.4e-11 41.8 0.4 2.4 2 0 0 2 2 2 2 KH domain Agenet PF05641.10 T141063_2 - 2.8e-12 46.8 5.4 5.1e-09 36.4 0.1 3.3 4 0 0 4 4 4 2 Agenet domain HMG_box_2 PF09011.8 T141063_2 - 6.1e-11 42.6 2.7 1.3e-10 41.6 2.7 1.6 1 0 0 1 1 1 1 HMG-box domain KH_2 PF07650.15 T141063_2 - 0.013 15.2 0.8 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 KH domain KH_4 PF13083.4 T141063_2 - 0.14 11.9 0.1 3.8 7.3 0.0 2.4 2 0 0 2 2 2 0 KH domain Sugar_tr PF00083.22 T309500_2 - 8.7e-19 67.6 27.2 1.1e-18 67.2 27.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 T309500_2 - 3.1e-14 52.5 33.5 3.1e-14 52.5 33.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily RhoGEF PF00621.18 T375545_1 - 1.6e-43 149.0 2.0 3.1e-43 148.0 2.0 1.5 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 T375545_1 - 8.8e-10 37.9 1.8 1.6e-09 37.1 1.8 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T375545_1 - 4.1e-09 36.0 0.1 8e-09 35.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T375545_1 - 5.1e-09 35.5 0.1 1.1e-08 34.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 T375545_1 - 1.4e-06 28.6 0.3 2.7e-06 27.7 0.3 1.4 1 0 0 1 1 1 1 PH domain EGF PF00008.25 T305959_1 - 3.1e-39 132.7 175.0 5.8e-06 26.4 5.4 17.5 16 1 1 17 17 17 13 EGF-like domain hEGF PF12661.5 T305959_1 - 1.1e-18 67.1 143.3 0.00095 19.6 6.1 16.4 15 0 0 15 15 15 12 Human growth factor-like EGF Laminin_G_2 PF02210.22 T305959_2 - 9.2e-75 249.1 2.5 4.5e-21 75.6 0.0 5.3 5 0 0 5 5 5 5 Laminin G domain Laminin_G_1 PF00054.21 T305959_2 - 2.8e-63 211.8 1.6 4.2e-19 68.9 0.0 5.3 5 0 0 5 5 5 5 Laminin G domain EGF PF00008.25 T305959_2 - 4.4e-45 151.4 175.5 4.2e-07 30.0 6.9 13.9 13 0 0 13 13 13 12 EGF-like domain hEGF PF12661.5 T305959_2 - 1.8e-20 72.6 159.4 1.1e-05 25.8 4.8 14.8 14 0 0 14 14 14 10 Human growth factor-like EGF Laminin_G_3 PF13385.4 T305959_2 - 3.8e-07 30.3 0.1 0.035 14.1 0.0 3.6 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily MRVI1 PF05781.10 T054734_1 - 2.2e-165 551.3 10.0 2.9e-165 550.9 10.0 1.1 1 0 0 1 1 1 1 MRVI1 protein DUF1725 PF08333.9 T054734_2 - 6.1e-08 32.0 0.7 1.2e-07 31.0 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Xlink PF00193.15 T054734_3 - 2.5e-18 66.1 0.0 6.6e-18 64.8 0.0 1.7 1 0 0 1 1 1 1 Extracellular link domain Dynein_heavy PF03028.13 T243385_1 - 8.1e-167 556.4 0.0 2.3e-166 554.9 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.5 T243385_1 - 1.3e-91 305.5 0.4 5.4e-90 300.2 0.7 2.5 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 T243385_1 - 1.1e-81 273.8 0.1 2.2e-81 272.9 0.1 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.5 T243385_1 - 3.1e-52 177.6 3.7 4.4e-52 177.1 3.7 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.5 T243385_1 - 5.3e-51 173.4 0.0 1.3e-50 172.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_6 PF12774.5 T243385_1 - 1.8e-20 73.6 0.0 5.2e-20 72.0 0.0 1.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_5 PF07728.12 T243385_1 - 1.3e-13 50.9 0.0 6e-06 26.2 0.0 3.7 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 T243385_1 - 1.3e-06 28.7 0.0 0.38 11.0 0.0 3.9 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.4 T243385_1 - 4.3e-06 26.9 0.0 0.52 10.4 0.0 3.8 3 0 0 3 3 3 2 AAA domain AAA PF00004.27 T243385_1 - 5.3e-05 23.5 0.3 2.7 8.3 0.0 4.3 5 0 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.18 T243385_1 - 0.00043 19.3 4.2 0.44 9.4 0.0 3.3 4 0 0 4 4 4 2 Type II/IV secretion system protein AAA_18 PF13238.4 T243385_1 - 0.00081 19.8 0.2 8.6 6.8 0.0 4.3 4 0 0 4 4 4 0 AAA domain Mg_chelatase PF01078.19 T243385_1 - 0.0012 18.1 0.0 0.24 10.6 0.0 3.4 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI ResIII PF04851.13 T243385_1 - 0.0015 18.4 0.0 1.3 8.9 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit ABC_tran PF00005.25 T243385_1 - 0.0015 18.9 0.4 0.21 11.9 0.0 3.2 3 0 0 3 3 3 1 ABC transporter AAA_33 PF13671.4 T243385_1 - 0.009 16.0 0.1 0.99 9.4 0.1 2.6 2 0 0 2 2 2 1 AAA domain DEAD PF00270.27 T243385_1 - 0.022 14.4 0.0 5.8 6.5 0.0 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_29 PF13555.4 T243385_1 - 0.031 13.9 3.3 0.21 11.2 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain RNA_helicase PF00910.20 T243385_1 - 0.032 14.5 0.1 3 8.1 0.0 3.2 3 0 0 3 3 2 0 RNA helicase Rad17 PF03215.13 T243385_1 - 0.054 12.3 0.3 4.7 5.9 0.0 2.3 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein AAA_30 PF13604.4 T243385_1 - 0.063 12.8 0.4 4.6 6.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.4 T243385_1 - 0.12 12.6 0.1 6.9 6.9 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_25 PF13481.4 T243385_1 - 0.13 11.7 0.5 3.6 7.0 0.1 2.5 2 0 0 2 2 2 0 AAA domain PhoH PF02562.14 T243385_1 - 0.16 11.3 0.1 1.3 8.3 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Alanine_zipper PF11839.6 T243385_1 - 2.2 8.5 8.8 7.7 6.7 8.8 1.9 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein DUF3584 PF12128.6 T243385_1 - 2.5 5.3 12.0 2.1 5.6 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) ISG65-75 PF11727.6 T243385_1 - 3.7 6.6 9.7 8.2 5.4 9.7 1.5 1 0 0 1 1 1 0 Invariant surface glycoprotein Fez1 PF06818.13 T243385_1 - 5.4 7.3 12.9 0.79 10.0 0.6 2.4 2 0 0 2 2 2 0 Fez1 DUF3450 PF11932.6 T243385_1 - 9.3 5.3 9.2 0.49 9.5 0.0 2.6 2 0 0 2 2 1 0 Protein of unknown function (DUF3450) Dynein_heavy PF03028.13 T243385_2 - 4.9e-92 309.2 0.4 6.4e-92 308.8 0.4 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.11 T243385_3 - 2.8e-144 481.0 14.5 2.8e-144 481.0 14.5 2.0 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 T243385_3 - 1.3e-69 234.3 0.0 2.2e-69 233.6 0.0 1.3 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 Seryl_tRNA_N PF02403.20 T243385_3 - 0.016 15.3 0.5 0.046 13.8 0.0 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain AAA_18 PF13238.4 T243385_3 - 0.02 15.3 0.0 0.12 12.7 0.0 2.4 1 0 0 1 1 1 0 AAA domain Kazal_2 PF07648.13 T291005_2 - 2.6e-118 385.8 77.3 5.9e-11 42.3 0.7 12.6 12 0 0 12 12 12 12 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 T291005_2 - 8.1e-76 249.7 88.9 5.3e-14 51.8 4.7 12.3 12 0 0 12 12 12 12 Kazal-type serine protease inhibitor domain Ntox1 PF15500.4 T291005_3 - 9.8 6.5 9.2 51 4.2 0.3 3.6 3 0 0 3 3 3 0 Putative RNase-like toxin, toxin_1 Defensin_2 PF01097.16 T253308_2 - 0.031 14.1 0.3 0.058 13.2 0.3 1.5 1 0 0 1 1 1 0 Arthropod defensin SH3_2 PF07653.15 T154426_1 - 6.5e-10 38.4 0.0 1.5e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T154426_1 - 1.7e-07 30.9 0.0 2.2e-06 27.3 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain Myosin_head PF00063.19 T154426_2 - 2e-50 171.6 0.0 2.4e-49 168.1 0.0 2.0 2 0 0 2 2 2 1 Myosin head (motor domain) MyTH4 PF00784.15 T154426_2 - 2.2e-46 156.6 7.2 1.2e-25 89.9 0.0 3.3 4 0 0 4 4 4 2 MyTH4 domain FERM_M PF00373.16 T154426_2 - 8.8e-15 55.0 1.9 9e-15 55.0 0.2 1.9 2 0 0 2 2 2 1 FERM central domain IQ PF00612.25 T154426_2 - 0.8 9.5 3.7 3.2 7.7 3.7 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif Myosin_head PF00063.19 T154426_3 - 1.2e-71 241.8 0.0 1.7e-71 241.3 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.4 T154426_3 - 0.019 15.2 0.0 0.04 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 T154426_3 - 0.024 14.8 0.0 0.042 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Aldedh PF00171.20 T143738_3 - 1.3e-97 327.1 0.0 1.7e-97 326.7 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family NTP_transferase PF00483.21 T242636_1 - 4.5e-48 163.9 0.0 6.9e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase LRR_8 PF13855.4 T242636_1 - 1.5e-20 72.6 20.3 9.5e-12 44.4 5.6 4.1 1 1 3 4 4 4 4 Leucine rich repeat NTP_transf_3 PF12804.5 T242636_1 - 4e-09 36.9 0.0 9.1e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.22 T242636_1 - 7.8e-09 34.8 4.5 1.6e-08 33.8 0.9 2.6 2 0 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) LRR_4 PF12799.5 T242636_1 - 0.00016 21.8 12.7 0.4 11.0 0.2 4.2 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) Ig_3 PF13927.4 T242636_1 - 0.0012 19.3 0.0 0.0031 18.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Hexapep_2 PF14602.4 T242636_1 - 0.43 10.3 6.0 0.07 12.8 1.8 1.9 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase IPK PF03770.14 T242636_2 - 1.4e-63 214.2 0.0 1.8e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase LRR_9 PF14580.4 T118949_2 - 2e-21 76.1 15.7 2.5e-13 49.8 2.8 3.4 2 1 1 3 3 3 3 Leucine-rich repeat LRR_4 PF12799.5 T118949_2 - 3.6e-19 68.3 35.1 5e-07 29.8 5.6 5.4 2 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T118949_2 - 9.7e-11 41.1 36.9 4.7e-07 29.4 8.4 4.6 2 1 2 4 4 4 3 Leucine rich repeat Rad9 PF04139.11 T061986_2 - 2.8e-35 121.9 1.0 9.2e-30 103.8 1.5 2.1 2 0 0 2 2 2 2 Rad9 Rad9 PF04139.11 T061986_3 - 4.2e-47 160.6 0.0 5.4e-47 160.2 0.0 1.1 1 0 0 1 1 1 1 Rad9 IZUMO PF15005.4 T165950_3 - 2e-28 99.7 0.2 2.7e-28 99.2 0.2 1.2 1 0 0 1 1 1 1 Izumo sperm-egg fusion, Ig domain-associated CCDC14 PF15254.4 T249387_3 - 0 1303.8 53.7 0 1021.4 41.2 2.0 1 1 1 2 2 2 2 Coiled-coil domain-containing protein 14 Oxysterol_BP PF01237.16 T010985_1 - 8.8e-81 271.4 8.3 6.9e-79 265.2 8.3 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein Snapin_Pallidin PF14712.4 T010985_1 - 0.7 10.2 5.5 0.095 13.0 1.4 1.6 2 0 0 2 2 2 0 Snapin/Pallidin PH_8 PF15409.4 T010985_2 - 0.00071 19.7 0.1 0.0018 18.4 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 T010985_2 - 0.00091 19.6 0.1 0.0017 18.7 0.1 1.4 1 0 0 1 1 1 1 PH domain Ion_trans PF00520.29 T202250_1 - 7.1e-257 847.3 103.8 1.7e-82 276.2 13.9 4.3 4 0 0 4 4 4 4 Ion transport protein Na_trans_cytopl PF11933.6 T202250_1 - 6.1e-66 222.2 17.2 7e-65 218.7 17.2 2.5 1 1 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.11 T202250_1 - 1.1e-55 188.7 1.9 1.1e-55 188.7 1.9 2.9 3 1 0 3 3 3 1 Sodium ion transport-associated PKD_channel PF08016.10 T202250_1 - 4.9e-06 25.4 82.6 0.00019 20.1 0.3 9.5 6 4 4 10 10 10 5 Polycystin cation channel GPHH PF16905.3 T202250_1 - 1.2e-05 24.9 0.0 2.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated ATP-synt_B PF00430.16 T202250_1 - 0.0013 18.7 5.2 0.005 16.8 5.2 2.1 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) Tmemb_9 PF05434.9 T202250_1 - 0.089 12.5 1.6 20 4.9 0.1 3.2 2 0 0 2 2 2 0 TMEM9 E2F_CC-MB PF16421.3 T005440_2 - 4.6e-34 116.6 0.3 7.3e-34 116.0 0.3 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.18 T005440_2 - 6.8e-21 73.9 0.1 1.2e-20 73.2 0.1 1.4 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain PDZ PF00595.22 T113442_1 - 1.8e-45 153.0 7.7 1.5e-15 57.1 0.2 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) ZU5 PF00791.18 T113442_1 - 9.2e-37 125.2 0.1 7.5e-36 122.3 0.0 2.3 2 0 0 2 2 2 1 ZU5 domain PDZ_2 PF13180.4 T113442_1 - 3.3e-15 56.0 4.9 0.00014 22.0 0.1 3.4 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.19 T113442_1 - 2.9e-12 46.5 0.0 4.6e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.15 T113442_1 - 2.1e-10 40.0 0.2 6.5e-10 38.4 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 T113442_1 - 0.03 13.8 0.1 0.095 12.2 0.0 2.0 2 0 0 2 2 2 0 SH3 domain CAP-ZIP_m PF15255.4 T041085_1 - 3.2e-52 176.4 6.7 2.9e-49 166.8 3.4 2.5 2 0 0 2 2 2 2 WASH complex subunit CAP-Z interacting, central region Nucleoporin_FG PF13634.4 T041085_2 - 6.8 7.5 15.4 16 6.3 0.0 5.2 4 2 1 5 5 5 0 Nucleoporin FG repeat region CcmD PF04995.12 T041085_3 - 3.2 7.8 9.5 3.3 7.7 1.2 2.9 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) CP2 PF04516.13 T005660_3 - 4.4e-78 261.6 0.0 6.7e-78 261.0 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor Ank_2 PF12796.5 T269814_2 - 2e-135 441.6 43.0 1.2e-17 64.1 0.2 11.2 1 1 8 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.28 T269814_2 - 1e-121 392.4 65.2 5.2e-07 29.7 0.5 21.5 20 1 1 21 21 21 19 Ankyrin repeat Ank_4 PF13637.4 T269814_2 - 2.6e-110 359.4 31.1 4e-11 43.1 0.6 14.2 6 4 9 16 16 16 16 Ankyrin repeats (many copies) Ank_5 PF13857.4 T269814_2 - 1.6e-106 346.3 48.5 2.6e-11 43.4 0.6 17.3 3 3 15 18 18 18 18 Ankyrin repeats (many copies) Ank_3 PF13606.4 T269814_2 - 3.2e-102 321.9 30.1 3.6e-05 23.7 0.0 22.0 21 0 0 21 21 21 19 Ankyrin repeat ZU5 PF00791.18 T269814_2 - 1.9e-34 117.7 0.5 2e-26 92.0 0.0 2.7 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 T269814_2 - 5e-22 77.8 0.9 1.1e-21 76.7 0.9 1.6 1 0 0 1 1 1 1 Death domain PK_C PF02887.14 T269814_2 - 8.5e-06 25.9 1.2 6.8 6.8 0.0 5.1 4 1 1 5 5 5 2 Pyruvate kinase, alpha/beta domain HTH_23 PF13384.4 T269814_2 - 0.16 11.7 0.1 1.4 8.7 0.1 2.7 2 0 0 2 2 2 0 Homeodomain-like domain Ank_2 PF12796.5 T269805_2 - 2.2e-149 486.3 45.6 1.3e-17 64.1 0.2 12.3 1 1 11 12 12 12 12 Ankyrin repeats (3 copies) Ank PF00023.28 T269805_2 - 1.8e-134 432.7 70.4 5.2e-07 29.7 0.5 23.5 22 1 1 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 T269805_2 - 9.1e-125 405.5 34.1 1.7e-12 47.4 0.1 15.3 7 4 9 17 17 17 17 Ankyrin repeats (many copies) Ank_5 PF13857.4 T269805_2 - 2e-119 387.4 48.6 2.6e-11 43.4 0.6 18.3 3 3 17 20 20 20 20 Ankyrin repeats (many copies) Ank_3 PF13606.4 T269805_2 - 2e-113 356.3 34.6 3.6e-05 23.7 0.0 24.0 23 0 0 23 23 23 21 Ankyrin repeat ZU5 PF00791.18 T269805_2 - 1.9e-34 117.7 0.5 2e-26 92.0 0.0 2.7 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 T269805_2 - 5.3e-22 77.6 0.9 1.1e-21 76.7 0.9 1.5 1 0 0 1 1 1 1 Death domain PK_C PF02887.14 T269805_2 - 2.8e-06 27.4 2.4 6.8 6.8 0.0 5.9 5 1 1 6 6 6 2 Pyruvate kinase, alpha/beta domain HTH_23 PF13384.4 T269805_2 - 0.11 12.2 0.1 1.4 8.7 0.1 3.0 2 0 0 2 2 2 0 Homeodomain-like domain Hist_deacetyl PF00850.17 T376271_1 - 6.6e-57 193.2 0.0 8.9e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Hep_59 PF07052.9 T220280_2 - 0.12 13.0 0.1 0.12 13.0 0.1 3.3 4 0 0 4 4 4 0 Hepatocellular carcinoma-associated antigen 59 AT_hook PF02178.17 T068483_2 - 0.76 9.7 11.4 0.49 10.3 3.1 3.7 2 0 0 2 2 2 0 AT hook motif BCL9 PF11502.6 T068483_3 - 2.4e-15 55.9 1.3 1.1e-14 53.8 1.3 2.2 1 0 0 1 1 1 1 B-cell lymphoma 9 protein Spin-Ssty PF02513.15 T375518_2 - 6.7e-64 211.3 14.7 5e-23 80.4 0.5 4.0 4 0 0 4 4 4 3 Spin/Ssty Family DSPc PF00782.18 T074178_3 - 2.1e-25 88.9 0.0 3.5e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 T074178_3 - 0.018 14.4 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Comm PF15957.3 T074178_3 - 0.059 13.6 0.8 0.16 12.2 0.8 1.7 1 0 0 1 1 1 0 Commissureless SH3_9 PF14604.4 T046500_3 - 4.8e-37 125.4 0.6 2.3e-14 52.8 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 T046500_3 - 1.4e-35 120.5 0.4 2.4e-10 39.7 0.0 3.6 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 T046500_3 - 1.7e-28 97.9 0.2 6.3e-12 44.9 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 T046500_3 - 4.5e-23 80.5 1.3 9.5e-23 79.5 1.3 1.6 1 0 0 1 1 1 1 Sorbin homologous domain Kelch_1 PF01344.23 T064101_2 - 5.9e-40 134.5 0.1 1e-10 40.9 0.0 6.8 6 0 0 6 6 6 6 Kelch motif BACK PF07707.13 T064101_2 - 8.1e-25 86.8 0.0 1.3e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_6 PF13964.4 T064101_2 - 4.2e-24 83.9 4.3 0.0023 18.0 0.0 6.6 2 1 4 6 6 6 6 Kelch motif Kelch_2 PF07646.13 T064101_2 - 1.1e-19 69.4 2.2 0.0092 15.8 0.0 6.7 6 0 0 6 6 6 5 Kelch motif BTB PF00651.29 T064101_2 - 2.5e-14 53.3 0.0 4.2e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.4 T064101_2 - 1e-12 47.8 0.8 0.011 15.9 0.0 6.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_4 PF13418.4 T064101_2 - 1.5e-12 47.1 0.1 1.3 8.9 0.0 6.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.4 T064101_2 - 1.3e-08 34.5 1.1 4.2 7.3 0.0 5.5 5 0 0 5 5 5 3 Kelch motif GDPD PF03009.15 T064101_3 - 1.6e-15 57.4 0.0 4.2e-15 56.1 0.0 1.6 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.4 T064101_3 - 0.023 15.1 0.0 0.045 14.2 0.0 1.4 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Syntaxin PF00804.23 T089587_2 - 4.5e-64 215.7 15.5 7.3e-64 215.0 15.5 1.3 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.17 T089587_2 - 3.8e-17 61.9 1.7 3.8e-17 61.9 1.7 3.2 3 0 0 3 3 3 1 SNARE domain Syntaxin_2 PF14523.4 T089587_2 - 7.2e-09 35.8 5.9 7.2e-09 35.8 5.9 2.2 2 1 0 2 2 2 1 Syntaxin-like protein DUF3671 PF12420.6 T089587_2 - 0.0058 16.6 10.0 0.043 13.8 10.0 2.3 1 1 0 1 1 1 1 Protein of unknown function Syntaxin-6_N PF09177.9 T089587_2 - 0.0091 16.4 1.2 0.0091 16.4 1.2 2.4 1 1 0 2 2 2 1 Syntaxin 6, N-terminal DUF2207 PF09972.7 T089587_2 - 0.027 13.1 3.3 0.031 13.0 0.1 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF16 PF01519.14 T089587_2 - 0.25 11.7 8.7 0.12 12.7 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 ApoLp-III PF07464.9 T089587_2 - 0.43 10.5 5.8 0.29 11.1 1.2 2.2 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) MCPsignal PF00015.19 T089587_2 - 0.76 9.4 6.9 2.7 7.6 1.0 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain YtxH PF12732.5 T089587_2 - 1.8 9.0 6.2 0.64 10.5 1.0 2.4 2 0 0 2 2 2 0 YtxH-like protein ABC_tran_CTD PF16326.3 T089587_2 - 2.7 8.2 4.7 5.9 7.1 0.2 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF1640 PF07798.9 T089587_2 - 9.1 6.2 13.1 0.046 13.6 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) RVT_1 PF00078.25 T053471_1 - 2.2e-15 56.7 0.0 3.3e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T053471_1 - 0.0034 16.8 0.2 0.14 11.6 0.0 2.1 2 0 0 2 2 2 2 Gag P30 core shell protein zf-H2C2_2 PF13465.4 T053471_2 - 2.9e-61 201.2 84.0 5.4e-08 32.8 0.9 12.6 12 0 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.24 T053471_2 - 9.5e-28 95.0 113.9 2.5e-05 24.4 0.5 14.5 15 0 0 15 15 15 10 Zinc finger, C2H2 type KRAB PF01352.25 T053471_2 - 9.2e-23 79.5 0.4 1.7e-22 78.7 0.4 1.5 1 0 0 1 1 1 1 KRAB box TLV_coat PF00429.17 T053471_2 - 7.2e-22 77.6 0.6 7.2e-22 77.6 0.6 2.1 2 0 0 2 2 2 1 ENV polyprotein (coat polyprotein) zf-C2H2_6 PF13912.4 T053471_2 - 2.9e-14 52.4 62.5 0.0019 18.0 2.8 11.9 11 0 0 11 11 11 7 C2H2-type zinc finger zf-C2H2_4 PF13894.4 T053471_2 - 0.00013 22.4 109.1 0.0019 18.8 3.2 14.6 15 0 0 15 15 15 8 C2H2-type zinc finger ADK_lid PF05191.12 T053471_2 - 0.045 13.6 35.7 0.16 11.9 1.2 6.6 6 0 0 6 6 6 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 T053471_2 - 4.5 7.3 74.2 0.065 13.2 2.4 8.9 5 2 4 10 10 10 0 Zinc ribbon domain RVP PF00077.18 T053471_3 - 1e-09 38.4 0.0 1.8e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RNase_H PF00075.22 T053471_3 - 8.5e-08 32.4 0.0 1.5e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-CCHC PF00098.21 T053471_3 - 1.2e-05 25.0 13.1 0.0096 15.8 0.7 2.8 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.4 T053471_3 - 0.098 13.2 0.0 0.19 12.3 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T053471_3 - 0.19 12.1 0.0 0.36 11.3 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_5 PF14787.4 T053471_3 - 2.2 7.9 17.1 3.4 7.3 2.2 2.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Hydrolase_4 PF12146.6 T360196_2 - 1.2e-11 44.2 0.0 4.2e-06 26.1 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.19 T360196_2 - 1e-06 28.2 0.0 6.6e-05 22.3 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.5 T360196_2 - 1.4e-05 25.7 0.0 0.00087 19.8 0.0 2.3 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 T360196_2 - 1.7e-05 24.4 0.1 0.065 12.7 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.16 T360196_2 - 0.0053 16.2 0.0 0.0083 15.6 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.11 T360196_2 - 0.017 14.7 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF818 PF05677.10 T360196_2 - 0.024 13.5 0.1 0.036 12.9 0.1 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) UPF0227 PF05728.10 T360196_2 - 0.027 14.3 0.0 0.22 11.3 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Asp2 PF16929.3 T360196_2 - 0.058 12.3 0.0 0.085 11.8 0.0 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Abhydrolase_5 PF12695.5 T360196_2 - 0.16 11.5 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family CH PF00307.29 T055877_1 - 2.8e-14 53.1 0.1 6.3e-14 52.0 0.1 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain AAA_22 PF13401.4 T055877_1 - 4.6e-05 23.6 0.2 0.0025 17.9 0.2 2.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.27 T055877_1 - 0.00046 20.5 0.1 0.0034 17.7 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.4 T055877_1 - 0.00058 19.8 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 T055877_1 - 0.0012 19.2 0.0 0.004 17.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 T055877_1 - 0.0016 18.7 0.1 0.14 12.4 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain CAMSAP_CH PF11971.6 T055877_1 - 0.0031 17.2 0.2 0.023 14.4 0.0 2.3 2 0 0 2 2 2 1 CAMSAP CH domain IncA PF04156.12 T055877_1 - 0.0099 15.6 11.4 0.16 11.6 2.5 2.8 2 0 0 2 2 2 2 IncA protein T2SSE PF00437.18 T055877_1 - 0.011 14.7 0.0 0.024 13.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.15 T055877_1 - 0.019 14.6 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.14 T055877_1 - 0.019 14.3 0.0 0.036 13.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_5 PF07728.12 T055877_1 - 0.048 13.5 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.4 T055877_1 - 0.052 13.8 0.2 0.13 12.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.4 T055877_1 - 0.06 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.4 T055877_1 - 0.069 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.4 T055877_1 - 0.17 11.3 0.0 0.37 10.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2205 PF10224.7 T055877_1 - 0.37 10.7 3.2 1.2 9.0 3.2 1.9 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) APG6 PF04111.10 T055877_1 - 0.74 9.0 17.2 0.4 9.9 1.4 3.0 3 0 0 3 3 3 0 Autophagy protein Apg6 DUF4407 PF14362.4 T055877_1 - 1.3 8.2 13.5 0.068 12.4 1.9 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) SlyX PF04102.10 T055877_1 - 3.6 8.1 11.1 0.98 10.0 0.2 3.6 2 1 1 3 3 3 0 SlyX Peptidase_M28 PF04389.15 T355302_1 - 2.1e-46 158.0 0.0 2.8e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.26 T355302_1 - 0.034 13.7 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 AAA_6 PF12774.5 T244019_1 - 4.5e-28 98.4 0.1 6.4e-28 97.9 0.1 1.1 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 Dynein_heavy PF03028.13 T244019_2 - 3.8e-288 957.4 0.0 4.8e-288 957.1 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.11 T244019_3 - 2.9e-105 352.5 7.4 2.9e-105 352.5 7.4 1.7 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.5 T244019_3 - 6e-52 176.5 0.1 9.7e-52 175.8 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_6 PF12774.5 T244019_3 - 2.1e-31 109.3 0.2 9.1e-31 107.2 0.0 2.2 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.5 T244019_3 - 6.5e-17 61.4 0.1 1.6e-16 60.2 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_5 PF07728.12 T244019_3 - 6.5e-14 52.0 0.0 2.1e-05 24.4 0.0 2.9 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA PF00004.27 T244019_3 - 0.0033 17.7 0.8 0.0095 16.2 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 T244019_3 - 0.028 14.7 0.0 1.4 9.1 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.20 T244019_3 - 0.049 13.9 0.0 1.5 9.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Hormone_recep PF00104.28 T170296_3 - 1.3e-35 122.8 0.0 2e-35 122.1 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor MCC-bdg_PDZ PF10506.7 T170296_3 - 1.7e-32 111.1 18.4 2.8e-28 97.6 3.4 2.7 2 0 0 2 2 2 2 PDZ domain of MCC-2 bdg protein for Usher syndrome zf-C4 PF00105.16 T170296_3 - 2.3e-31 107.9 17.7 4.5e-31 107.0 17.7 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Mei5 PF10376.7 T170296_3 - 1.2 8.8 7.8 0.78 9.4 0.4 2.2 2 0 0 2 2 2 0 Double-strand recombination repair protein FlaC_arch PF05377.9 T170296_3 - 1.4 9.3 6.5 2.8 8.3 1.0 2.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Spc24 PF08286.9 T170296_3 - 4.4 7.5 4.8 43 4.3 0.1 2.6 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 HALZ PF02183.16 T170296_3 - 10 6.3 9.6 0.32 11.1 2.0 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper Cpn60_TCP1 PF00118.22 T145710_2 - 1.8e-163 544.6 10.0 2.1e-163 544.4 10.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Roc PF08477.11 T145354_2 - 0.0016 18.5 0.0 0.0024 18.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 T145354_2 - 0.011 15.2 0.0 0.015 14.8 0.0 1.1 1 0 0 1 1 1 0 Ras family MMR_HSR1 PF01926.21 T145354_2 - 0.14 12.2 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase EF_assoc_2 PF08356.10 T145354_3 - 1.4e-35 121.0 0.0 3.5e-35 119.7 0.0 1.8 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.10 T145354_3 - 2.3e-29 100.7 2.4 1.1e-28 98.6 0.9 2.3 2 0 0 2 2 2 1 EF hand associated Ras PF00071.20 T145354_3 - 3e-18 65.8 1.3 1.7e-11 43.9 0.1 2.6 2 1 0 2 2 2 2 Ras family EF-hand_7 PF13499.4 T145354_3 - 7.4e-06 26.2 1.0 0.013 15.8 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 T145354_3 - 9.7e-06 24.7 3.2 0.08 12.4 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T145354_3 - 2.8e-05 23.6 4.1 0.012 15.4 0.2 3.0 3 0 0 3 3 3 2 EF-hand domain Roc PF08477.11 T145354_3 - 0.00028 21.0 0.3 0.15 12.2 0.0 3.0 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Rad4 PF03835.13 T145354_3 - 0.0033 17.0 0.0 0.0066 16.0 0.0 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain EF-hand_8 PF13833.4 T145354_3 - 0.046 13.4 1.1 1.2 8.8 0.1 2.7 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.4 T145354_3 - 0.12 11.8 2.8 2 8.0 0.1 2.5 2 0 0 2 2 2 0 EF hand MMR_HSR1 PF01926.21 T145354_3 - 0.21 11.5 0.4 1.3 9.0 0.1 2.4 2 1 0 2 2 2 0 50S ribosome-binding GTPase DUF2722 PF10846.6 T098741_2 - 0.0016 17.3 6.2 0.0025 16.7 6.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.6 T098741_2 - 0.06 12.8 16.0 0.1 12.1 16.0 1.3 1 0 0 1 1 1 0 Spt20 family Hydin_ADK PF17213.1 T098741_2 - 0.12 12.5 1.6 0.32 11.1 1.6 1.7 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain PaO PF08417.10 T098741_2 - 0.15 12.1 0.1 0.15 12.1 0.1 1.8 2 0 0 2 2 2 0 Pheophorbide a oxygenase Kei1 PF08552.9 T098741_2 - 0.38 10.3 0.8 0.63 9.6 0.8 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Sugar_tr PF00083.22 T098741_2 - 0.46 9.1 0.8 0.67 8.6 0.8 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter TFIIA PF03153.11 T098741_2 - 0.91 9.3 15.2 1.7 8.5 15.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Connexin PF00029.17 T098741_2 - 7.6 6.1 6.3 0.86 9.2 1.2 1.9 2 0 0 2 2 2 0 Connexin Cytomega_UL84 PF06284.9 T098741_3 - 0.56 8.5 7.1 1.1 7.5 7.1 1.4 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Ank_2 PF12796.5 T170314_1 - 1.4e-14 54.3 0.0 1.6e-07 31.7 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T170314_1 - 3.2e-08 33.8 0.8 6.5e-07 29.6 0.1 2.8 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 T170314_1 - 1.1e-07 31.9 1.2 1.2e-05 25.4 0.2 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.28 T170314_1 - 1.1e-07 31.8 1.2 0.033 14.5 0.0 4.8 5 0 0 5 5 5 2 Ankyrin repeat LEM PF03020.13 T170314_1 - 9.5e-06 24.9 0.0 2e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 LEM domain Ank_3 PF13606.4 T170314_1 - 6.8e-05 22.8 0.9 0.31 11.6 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat Ank_2 PF12796.5 T139739_1 - 3.9e-20 72.1 1.3 8.8e-09 35.7 0.3 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T139739_1 - 5.6e-12 44.6 0.1 0.19 12.2 0.0 5.1 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.28 T139739_1 - 7.6e-12 45.0 0.2 0.043 14.1 0.1 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.4 T139739_1 - 6.6e-10 38.9 0.1 0.18 12.1 0.1 3.9 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 T139739_1 - 1e-06 29.1 0.3 0.049 14.1 0.0 4.5 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ion_trans PF00520.29 T139739_2 - 1.8e-10 40.4 7.4 1.8e-10 40.4 7.4 2.2 2 0 0 2 2 2 1 Ion transport protein Pox_polyA_pol PF03296.11 T139739_2 - 0.024 14.4 0.2 0.045 13.5 0.2 1.3 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase nucleotidyltransferase domain APS_kinase PF01583.18 T045722_3 - 7.2e-71 237.1 0.0 1.1e-70 236.5 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.15 T045722_3 - 9.1e-64 214.7 0.0 7.3e-54 182.4 0.0 2.4 2 0 0 2 2 2 2 ATP-sulfurylase PUA_2 PF14306.4 T045722_3 - 1.8e-51 173.8 0.0 3.1e-51 173.1 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.4 T045722_3 - 0.00015 21.8 0.0 0.00033 20.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 T045722_3 - 0.007 16.7 0.0 0.018 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain MFS_1 PF07690.14 T298993_2 - 3.9e-05 22.6 0.6 6.6e-05 21.9 0.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Eapp_C PF10238.7 T298993_2 - 5.2 7.0 8.7 9.3 6.2 8.7 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein LBP_BPI_CETP PF01273.23 T216356_3 - 8.6e-40 135.9 0.8 1.1e-39 135.5 0.8 1.1 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain SSF PF00474.15 T010697_2 - 1e-96 324.2 5.0 1.4e-96 323.7 5.0 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family OppC_N PF12911.5 T010697_2 - 0.004 17.0 0.2 0.004 17.0 0.2 2.3 2 0 0 2 2 2 1 N-terminal TM domain of oligopeptide transport permease C DUF2569 PF10754.7 T010697_2 - 0.99 9.7 8.3 0.059 13.7 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) SSF PF00474.15 T010697_3 - 1.5e-34 119.5 7.0 2e-34 119.0 7.0 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family AAA PF00004.27 T323885_3 - 4.8e-37 127.2 0.0 8e-37 126.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 T323885_3 - 1.2e-06 28.3 0.0 2.5e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.10 T323885_3 - 0.001 18.3 0.0 0.0016 17.6 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.12 T323885_3 - 0.0095 15.9 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.12 T323885_3 - 0.0098 15.8 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 T323885_3 - 0.032 14.5 0.8 0.19 11.9 0.9 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 T323885_3 - 0.12 12.6 0.7 0.79 9.9 0.6 2.0 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.11 T323885_3 - 0.17 10.7 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 TIP49 C-terminus CC2D2AN-C2 PF15625.4 T046595_1 - 0.00072 19.2 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain Dynein_heavy PF03028.13 T141103_1 - 4.9e-261 867.8 0.0 6.3e-261 867.5 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.5 T141103_1 - 1.8e-46 157.9 0.2 2.9e-46 157.2 0.2 1.3 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 Mucin PF01456.15 T141103_1 - 6.1 6.7 22.1 1.4 8.8 1.3 2.7 2 0 0 2 2 2 0 Mucin-like glycoprotein DHC_N2 PF08393.11 T141103_2 - 5.6e-140 466.8 14.1 5.6e-140 466.8 14.1 2.9 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.10 T141103_2 - 5.4e-108 361.9 1.5 4.7e-67 226.8 0.0 4.0 4 1 1 5 5 5 2 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.5 T141103_2 - 1.4e-99 332.4 0.0 2.3e-98 328.5 0.0 2.3 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.5 T141103_2 - 5.1e-71 238.9 0.0 1.4e-70 237.5 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 T141103_2 - 1.1e-57 195.2 0.1 1.8e-57 194.6 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.5 T141103_2 - 2.3e-52 178.0 9.1 3.9e-52 177.3 9.1 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.5 T141103_2 - 6.1e-34 116.9 0.0 2.2e-33 115.1 0.0 2.0 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_5 PF07728.12 T141103_2 - 2.3e-33 115.0 0.0 5.8e-19 68.3 0.0 4.8 4 0 0 4 4 4 3 AAA domain (dynein-related subfamily) JmjC PF02373.20 T141103_2 - 2.7e-31 108.2 1.6 6e-31 107.1 1.6 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase AAA PF00004.27 T141103_2 - 1.4e-11 44.8 1.0 0.00014 22.2 0.0 5.0 6 0 0 6 6 5 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 T141103_2 - 1.6e-08 34.7 0.2 0.019 15.1 0.0 4.6 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.4 T141103_2 - 2.8e-07 31.0 2.7 0.024 14.9 0.0 5.2 5 0 0 5 5 4 1 AAA ATPase domain AAA_18 PF13238.4 T141103_2 - 0.0001 22.7 0.0 9.3 6.6 0.0 4.7 4 0 0 4 4 4 0 AAA domain TsaE PF02367.15 T141103_2 - 0.00025 20.9 0.1 1.4 8.8 0.0 3.5 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.18 T141103_2 - 0.00046 19.2 0.1 0.078 11.9 0.0 2.8 3 0 0 3 3 3 1 Type II/IV secretion system protein Mg_chelatase PF01078.19 T141103_2 - 0.0017 17.6 0.1 0.6 9.3 0.0 3.8 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.24 T141103_2 - 0.0019 17.8 0.0 0.048 13.2 0.0 2.8 3 0 0 3 3 3 1 Sigma-54 interaction domain DUF3452 PF11934.6 T141103_2 - 0.0052 16.2 0.6 0.24 10.8 0.1 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3452) AAA_33 PF13671.4 T141103_2 - 0.012 15.7 0.6 2.2 8.3 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.4 T141103_2 - 0.022 14.4 0.8 8.5 5.9 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_2 PF07724.12 T141103_2 - 0.055 13.5 0.0 0.2 11.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.4 T141103_2 - 0.066 13.2 0.0 0.54 10.2 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain ResIII PF04851.13 T141103_2 - 0.081 12.8 0.0 4.5 7.1 0.0 3.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit IstB_IS21 PF01695.15 T141103_2 - 0.081 12.6 0.0 0.36 10.4 0.0 2.1 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.11 T141103_2 - 0.092 11.7 0.0 1.2 8.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_25 PF13481.4 T141103_2 - 0.1 12.1 0.6 8 5.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain CbiA PF01656.21 T141103_2 - 0.15 12.0 0.0 0.57 10.1 0.0 2.0 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.15 T141103_2 - 0.54 9.8 3.3 0.37 10.4 0.1 2.4 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein TPR_2 PF07719.15 T141103_2 - 0.61 10.2 2.2 3.8 7.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Guanylate_kin PF00625.19 T141103_2 - 1 8.9 3.6 0.28 10.7 0.0 1.9 2 0 0 2 2 1 0 Guanylate kinase AAA_19 PF13245.4 T141103_2 - 2.3 8.4 4.3 11 6.3 0.0 3.6 4 0 0 4 4 4 0 AAA domain Rootletin PF15035.4 T004338_2 - 1.2e-64 217.7 25.4 1.2e-64 217.7 25.4 13.5 3 2 7 10 10 10 1 Ciliary rootlet component, centrosome cohesion FHA PF00498.24 T006464_3 - 8.3e-16 58.0 0.1 1.5e-15 57.1 0.1 1.5 1 0 0 1 1 1 1 FHA domain Ras PF00071.20 T335959_1 - 3.1e-16 59.3 0.0 4.2e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T335959_1 - 0.036 14.2 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ArfGap PF01412.16 T335959_3 - 1.4e-36 124.9 0.0 4.5e-36 123.3 0.0 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.27 T335959_3 - 1.5e-10 41.4 0.0 3.6e-10 40.2 0.0 1.7 1 1 0 1 1 1 1 PH domain Ank_2 PF12796.5 T335959_3 - 2e-06 28.1 0.0 3.8e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T335959_3 - 0.00013 22.3 0.0 0.045 14.2 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 T335959_3 - 0.00022 21.4 0.0 0.23 11.8 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 T335959_3 - 0.0096 16.2 0.2 0.048 13.9 0.1 2.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) PH_6 PF15406.4 T335959_3 - 0.043 14.0 0.1 0.072 13.2 0.1 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain Cul7 PF11515.6 T303927_2 - 5.5e-33 113.0 0.2 1.8e-32 111.3 0.1 2.0 2 0 0 2 2 2 1 Mouse development and cellular proliferation protein Cullin-7 Cullin PF00888.20 T303927_2 - 1.2e-24 86.7 0.0 2.2e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Cullin family IBR PF01485.19 T303927_2 - 9.8e-13 48.0 32.9 1e-08 35.1 12.9 3.4 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain ANAPC10 PF03256.14 T303927_2 - 5.4e-09 35.8 0.0 1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Cullin_Nedd8 PF10557.7 T303927_2 - 1.5e-07 31.2 0.0 3.5e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain SRF-TF PF00319.16 T303927_3 - 9.2e-19 66.5 0.1 1.7e-18 65.7 0.1 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) IRF-3 PF10401.7 T216014_1 - 0.023 14.4 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 Interferon-regulatory factor 3 Collar PF07484.10 T216014_2 - 0.091 12.7 0.6 0.5 10.3 0.1 2.4 2 0 0 2 2 2 0 Phage Tail Collar Domain Forkhead PF00250.16 T216014_3 - 1.3e-36 124.6 0.0 2e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain IRF-3 PF10401.7 T216014_3 - 9.4e-10 38.4 0.0 1.6e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 TPR_1 PF00515.26 T239835_3 - 8e-12 44.3 14.9 0.00027 20.5 0.0 6.4 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.15 T239835_3 - 4.4e-09 35.6 25.2 0.028 14.4 0.2 8.4 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_12 PF13424.4 T239835_3 - 7.1e-07 29.3 12.2 0.046 13.9 0.2 6.6 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.4 T239835_3 - 2.4e-05 24.6 16.5 0.11 12.9 0.0 7.5 8 2 2 10 10 10 1 Tetratricopeptide repeat SRP_TPR_like PF17004.3 T239835_3 - 6.9e-05 22.7 3.7 0.15 12.0 0.2 3.5 3 0 0 3 3 3 2 Putative TPR-like repeat TPR_8 PF13181.4 T239835_3 - 0.00011 21.9 8.9 0.04 14.0 0.0 5.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.4 T239835_3 - 0.00012 21.8 1.2 0.038 13.9 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.5 T239835_3 - 0.00076 19.5 16.6 5.9 7.0 0.2 6.4 5 1 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.4 T239835_3 - 0.00099 19.6 6.6 1.1 10.1 0.1 6.1 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_10 PF13374.4 T239835_3 - 0.002 17.8 2.2 0.6 10.0 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.4 T239835_3 - 0.015 15.5 14.0 5.1 7.6 0.1 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.4 T239835_3 - 0.078 13.6 0.2 8.1 7.1 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF948 PF06103.9 T239835_3 - 0.16 12.1 0.3 0.48 10.6 0.3 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) TPR_6 PF13174.4 T239835_3 - 0.79 10.4 4.7 48 4.8 0.1 4.8 6 0 0 6 6 4 0 Tetratricopeptide repeat POX PF07526.9 T239835_3 - 3.5 8.1 6.0 7.5 7.0 0.1 3.1 3 0 0 3 3 3 0 Associated with HOX Kinesin PF00225.21 T129942_1 - 2.7e-91 305.8 0.0 3.7e-91 305.4 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Vault PF01505.16 T129942_1 - 4.3e-56 186.8 5.5 4.8e-15 55.4 0.0 4.8 4 0 0 4 4 4 4 Major Vault Protein repeat MVP_shoulder PF11978.6 T129942_1 - 1.1e-51 173.6 0.0 1.9e-51 172.9 0.0 1.4 1 0 0 1 1 1 1 Shoulder domain Microtub_bd PF16796.3 T129942_1 - 1.2e-19 70.7 0.0 1.9e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding zf-C2H2_4 PF13894.4 T129942_1 - 2e-18 65.3 53.9 0.0018 18.8 3.4 8.9 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2 PF00096.24 T129942_1 - 6.3e-18 64.0 56.7 5.8e-05 23.2 3.7 8.7 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T129942_1 - 1.3e-13 50.6 50.6 7.8e-05 22.8 2.8 8.6 8 0 0 8 8 8 4 Zinc-finger double domain Band_7 PF01145.23 T129942_1 - 0.00053 19.9 0.3 0.0013 18.7 0.3 1.6 1 0 0 1 1 1 1 SPFH domain / Band 7 family zf-C2H2_6 PF13912.4 T129942_1 - 0.00091 19.0 35.6 0.0085 15.9 2.1 7.2 7 0 0 7 7 7 3 C2H2-type zinc finger zf-met PF12874.5 T129942_1 - 0.002 18.3 38.4 0.093 13.0 1.1 7.1 7 0 0 7 7 7 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T129942_1 - 0.0029 17.7 35.0 0.27 11.5 0.1 6.9 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding GAGA PF09237.9 T129942_1 - 0.83 9.4 5.9 6.9 6.4 0.0 3.9 4 0 0 4 4 4 0 GAGA factor DZR PF12773.5 T129942_1 - 3.5 7.6 19.1 0.45 10.5 0.9 3.8 2 1 0 2 2 2 0 Double zinc ribbon HHH_3 PF12836.5 T129942_2 - 2.7e-10 40.2 0.0 4.6e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_6 PF14579.4 T129942_2 - 0.1 12.7 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Helix-hairpin-helix motif PAXIP1_C PF15364.4 T129942_3 - 2.9e-48 163.5 5.6 5.3e-48 162.6 5.6 1.4 1 0 0 1 1 1 1 PAXIP1-associated-protein-1 C term PTIP binding protein CD225 PF04505.10 T129942_3 - 1.5e-22 79.3 0.7 3.1e-22 78.3 0.7 1.5 1 0 0 1 1 1 1 Interferon-induced transmembrane protein zf-CCCH PF00642.22 T173957_1 - 0.012 15.4 0.5 0.035 13.9 0.5 1.9 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH PF00642.22 T173957_2 - 0.027 14.2 2.4 0.074 12.9 2.4 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.20 T173957_3 - 0.00061 19.4 0.0 0.00098 18.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RYDR_ITPR PF01365.19 T114011_1 - 8.6e-138 456.3 8.3 1.4e-73 246.6 0.0 3.2 3 0 0 3 3 3 2 RIH domain RyR PF02026.14 T114011_1 - 1.1e-123 403.5 2.0 2.7e-33 113.9 0.0 4.8 4 0 0 4 4 4 4 RyR domain SPRY PF00622.26 T114011_1 - 4.1e-65 217.2 0.6 4.6e-20 71.8 0.0 3.7 3 0 0 3 3 3 3 SPRY domain MIR PF02815.17 T114011_1 - 3.3e-60 203.0 0.1 4.2e-55 186.3 0.0 2.4 2 0 0 2 2 2 2 MIR domain Ins145_P3_rec PF08709.9 T114011_1 - 4e-59 199.3 0.0 1.7e-56 190.7 0.0 3.4 2 1 1 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RR_TM4-6 PF06459.10 T114011_3 - 3.9e-56 190.8 12.6 3.1e-31 109.1 7.5 4.0 3 1 1 4 4 4 2 Ryanodine Receptor TM 4-6 RIH_assoc PF08454.9 T114011_3 - 4.9e-30 103.2 0.2 4.9e-30 103.2 0.2 2.1 2 0 0 2 2 2 1 RyR and IP3R Homology associated Ion_trans PF00520.29 T114011_3 - 9.2e-14 51.1 3.0 9.2e-14 51.1 3.0 2.1 3 0 0 3 3 3 1 Ion transport protein EF-hand_1 PF00036.30 T114011_3 - 0.00013 21.1 0.1 0.00027 20.1 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 T114011_3 - 0.0017 18.0 0.4 0.0041 16.7 0.4 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T114011_3 - 0.0017 18.0 0.0 0.0051 16.5 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.4 T114011_3 - 0.073 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.4 T114011_3 - 0.15 12.5 5.8 0.019 15.3 1.1 2.0 2 0 0 2 2 2 0 EF-hand domain pair Pkinase PF00069.23 T029150_3 - 1.3e-66 224.5 0.0 1.8e-66 224.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T029150_3 - 8.3e-27 94.0 0.0 1.2e-26 93.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 T029150_3 - 6.7e-05 22.2 0.0 0.00011 21.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 T029150_3 - 0.00094 18.4 0.0 0.0014 17.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Mito_carr PF00153.25 T061131_1 - 1.3e-17 63.4 1.1 2.1e-17 62.7 0.3 1.7 2 0 0 2 2 2 1 Mitochondrial carrier protein Mito_carr PF00153.25 T061131_3 - 9.7e-38 127.9 0.0 1.5e-19 69.5 0.1 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein Gelsolin PF00626.20 T039151_3 - 1.9e-19 69.2 0.3 5.9e-05 22.8 0.0 5.6 5 0 0 5 5 5 4 Gelsolin repeat VHP PF02209.17 T039151_3 - 6e-16 58.1 0.3 3.4e-15 55.7 0.3 2.3 2 0 0 2 2 2 1 Villin headpiece domain DUF4695 PF15766.3 T039151_3 - 0.0035 17.4 2.3 0.17 12.0 0.1 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4695) Na_H_Exchanger PF00999.19 T276970_1 - 8.8e-85 284.6 50.5 1.1e-84 284.3 50.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.3 T276970_1 - 0.27 11.4 6.2 0.54 10.4 6.2 1.5 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Pkinase PF00069.23 T175127_1 - 6.4e-66 222.3 0.0 8.1e-66 221.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T175127_1 - 3.9e-42 144.2 0.0 5.5e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 T175127_1 - 1.3e-15 57.4 0.0 2.6e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 T175127_1 - 1.2e-06 27.9 0.0 1.7e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like SRF-TF PF00319.16 T022513_2 - 6.9e-24 82.9 0.4 1.3e-23 82.0 0.4 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 T022513_2 - 1.1e-07 31.6 0.0 1.1e-07 31.6 0.0 2.8 2 1 0 2 2 2 1 Holliday junction regulator protein family C-terminal repeat DUF2360 PF10152.7 T022513_2 - 0.13 12.5 3.3 0.22 11.8 3.3 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) TFIIA PF03153.11 T022513_2 - 2.5 7.9 14.8 3.7 7.3 14.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.11 T022513_2 - 3.8 8.1 15.2 9.7 6.8 15.2 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Phosphodiest PF01663.20 T275463_3 - 1.9e-55 188.8 0.7 2.5e-55 188.4 0.7 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.16 T275463_3 - 0.023 13.9 0.0 0.036 13.3 0.0 1.1 1 0 0 1 1 1 0 Metalloenzyme superfamily PglZ PF08665.10 T275463_3 - 0.12 12.4 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 PglZ domain CD20 PF04103.13 T059487_3 - 1.5e-46 158.2 6.2 2.6e-46 157.4 6.2 1.4 1 0 0 1 1 1 1 CD20-like family CM2 PF03021.12 T059487_3 - 0.1 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Influenza C virus M2 protein GluR_Homer-bdg PF10606.7 T313183_1 - 2.5e-24 85.0 10.5 2.5e-24 85.0 10.5 2.4 2 0 0 2 2 2 1 Homer-binding domain of metabotropic glutamate receptor ANF_receptor PF01094.26 T313183_3 - 8.6e-93 311.1 0.0 1.2e-92 310.7 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 T313183_3 - 6.1e-56 189.7 27.9 6.1e-56 189.7 27.9 2.6 3 0 0 3 3 3 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 T313183_3 - 2.4e-14 52.9 10.7 2.4e-14 52.9 10.7 2.1 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR DUF2318 PF10080.7 T313183_3 - 0.13 12.2 3.2 0.28 11.2 3.2 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) MAGE_N PF12440.6 T313183_3 - 0.47 11.0 3.2 1 9.9 3.2 1.5 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal CAF-1_p60_C PF15512.4 T313183_3 - 0.49 10.7 4.5 0.82 10.0 4.5 1.3 1 0 0 1 1 1 0 Chromatin assembly factor complex 1 subunit p60, C-terminal Miff PF05644.9 T208999_3 - 4.1e-138 459.8 2.5 5.1e-138 459.5 2.5 1.1 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff Vps16_N PF04841.11 T212780_3 - 8e-147 489.1 0.0 1.3e-123 412.6 0.0 2.1 1 1 1 2 2 2 2 Vps16, N-terminal region Vps16_C PF04840.10 T212780_3 - 6.3e-145 482.1 1.0 8.7e-145 481.6 1.0 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region FliO PF04347.11 T212780_3 - 0.12 12.6 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 Flagellar biosynthesis protein, FliO Pkinase_Tyr PF07714.15 T049733_3 - 1.6e-103 345.4 0.0 2.3e-103 344.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T049733_3 - 2.6e-44 151.4 0.0 4.1e-44 150.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 T049733_3 - 1.2e-33 114.9 0.0 1.2e-13 50.7 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 T049733_3 - 1.7e-33 115.0 0.1 1.4e-11 44.7 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T049733_3 - 4.4e-23 81.3 0.2 1.9e-09 37.6 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T049733_3 - 6.5e-22 77.4 0.0 2.6e-08 33.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T049733_3 - 1e-12 48.0 0.3 0.0013 18.7 0.0 4.4 4 1 0 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.3 T049733_3 - 8.6e-05 22.7 0.0 0.47 10.8 0.0 3.5 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 T049733_3 - 0.086 12.8 0.0 1.3 9.0 0.0 3.0 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Lipocalin PF00061.21 T369751_1 - 2e-33 115.5 0.0 2.6e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 T369751_1 - 0.028 14.2 0.0 0.044 13.5 0.0 1.2 1 0 0 1 1 1 0 Triabin Lipocalin PF00061.21 T369751_2 - 2.8e-10 40.4 0.0 4.2e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Ank_2 PF12796.5 T290135_2 - 2.9e-148 482.7 36.8 1.1e-16 61.1 0.1 12.8 3 3 8 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T290135_2 - 1.2e-118 385.9 17.4 1e-09 38.6 0.1 15.9 9 3 7 17 17 17 16 Ankyrin repeats (many copies) Ank PF00023.28 T290135_2 - 6.2e-112 361.5 50.4 5.5e-08 32.8 0.0 24.6 24 0 0 24 24 24 23 Ankyrin repeat Ank_3 PF13606.4 T290135_2 - 9.4e-102 320.4 28.0 7.2e-05 22.8 0.0 25.5 25 0 0 25 25 25 23 Ankyrin repeat Ank_5 PF13857.4 T290135_2 - 8.1e-96 312.3 47.2 6e-08 32.7 0.0 21.6 6 5 16 22 22 22 21 Ankyrin repeats (many copies) KH_1 PF00013.27 T290135_2 - 1.2e-14 53.7 0.6 3.2e-14 52.4 0.6 1.8 1 0 0 1 1 1 1 KH domain eIF_4EBP PF05456.9 T290135_3 - 2.3e-20 72.5 0.1 4.8e-20 71.5 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Fibrillarin PF01269.15 T175377_1 - 9.5e-108 358.4 0.0 1.2e-107 358.0 0.0 1.1 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.8 T175377_1 - 0.0014 18.3 0.0 0.002 17.7 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.17 T175377_1 - 0.017 14.7 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.17 T175377_1 - 0.21 11.5 0.0 0.38 10.7 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase Pkinase PF00069.23 T175377_2 - 1.9e-49 168.3 0.0 2.6e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T175377_2 - 1.9e-21 76.4 0.0 2.7e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 T175377_2 - 0.12 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family MatE PF01554.16 T143721_1 - 2.6e-21 75.8 1.0 3.6e-21 75.4 1.0 1.2 1 0 0 1 1 1 1 MatE MatE PF01554.16 T143721_2 - 8.3e-07 28.7 0.2 2e-06 27.5 0.2 1.6 1 0 0 1 1 1 1 MatE DUF2681 PF10883.6 T143721_2 - 0.93 9.8 3.2 0.29 11.5 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) MatE PF01554.16 T143721_3 - 3.1e-10 39.8 2.9 3.1e-10 39.8 2.9 2.4 2 0 0 2 2 2 1 MatE Polysacc_synt_C PF14667.4 T143721_3 - 5e-05 23.3 10.3 0.00011 22.1 10.3 1.5 1 0 0 1 1 1 1 Polysaccharide biosynthesis C-terminal domain CSD PF00313.20 T073905_1 - 2.3e-25 88.1 0.5 3.9e-25 87.4 0.5 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.9 T073905_1 - 0.067 12.8 0.0 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 Ribonuclease B OB domain Herpes_LMP1 PF05297.9 T073905_1 - 0.38 9.8 4.3 0.64 9.0 4.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Zona_pellucida PF00100.21 T050043_3 - 1.4e-49 169.1 12.7 2.3e-49 168.3 12.7 1.4 1 0 0 1 1 1 1 Zona pellucida-like domain CUB PF00431.18 T050043_3 - 2.3e-39 134.0 0.6 4.2e-27 94.5 0.1 2.4 2 0 0 2 2 2 2 CUB domain FAM24 PF15193.4 T050043_3 - 8.1e-27 93.6 3.6 2.3e-26 92.1 3.6 1.8 1 0 0 1 1 1 1 FAM24 family CUB_2 PF02408.18 T050043_3 - 0.089 12.4 1.0 0.84 9.3 0.2 2.5 2 0 0 2 2 2 0 CUB-like domain Aa_trans PF01490.16 T282442_2 - 3.6e-25 88.4 36.8 6.4e-13 48.1 7.5 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Sulfotransfer_1 PF00685.25 T129198_2 - 0.00021 20.8 0.0 0.00029 20.3 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain GCV_T PF01571.19 T284738_2 - 2e-68 230.4 0.0 2.5e-68 230.1 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.22 T284738_2 - 4.6e-15 55.9 0.0 6.7e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAO_M PF16350.3 T284738_2 - 8.3e-13 48.3 0.1 1.6e-12 47.4 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain SoxG PF04268.10 T284738_2 - 3e-07 30.6 0.0 4.8e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Sarcosine oxidase, gamma subunit family DAO PF01266.22 T284738_3 - 0.001 18.6 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Rod_cone_degen PF15201.4 T154896_3 - 4e-06 26.7 3.7 1e-05 25.4 3.7 1.7 1 0 0 1 1 1 1 Progressive rod-cone degeneration Cadherin PF00028.15 T043595_1 - 0 1316.7 23.5 1.3e-19 70.3 0.0 25.3 25 0 0 25 25 25 25 Cadherin domain Cadherin_2 PF08266.10 T043595_1 - 2.5e-22 78.3 0.0 0.17 11.6 0.0 13.2 14 0 0 14 14 14 8 Cadherin-like Cadherin_3 PF16184.3 T043595_1 - 1.8e-18 66.4 30.1 0.0073 16.2 0.0 17.1 19 0 0 19 19 19 6 Cadherin-like Cadherin_pro PF08758.9 T043595_1 - 1.8e-07 31.1 0.0 5.5 7.1 0.0 8.6 11 0 0 11 11 11 1 Cadherin prodomain like DUF3364 PF11844.6 T043595_1 - 8 6.7 7.4 19 5.4 0.1 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF3364) 2TM PF13239.4 T237410_2 - 3.1 8.0 6.0 0.75 10.0 0.6 2.6 2 0 0 2 2 2 0 2TM domain UPF0020 PF01170.16 T237410_3 - 1.2e-48 165.3 0.0 1.7e-48 164.8 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 THUMP PF02926.15 T237410_3 - 2.6e-11 43.7 0.9 5.5e-11 42.6 0.5 1.8 1 1 1 2 2 2 1 THUMP domain Methyltransf_25 PF13649.4 T237410_3 - 0.002 18.7 0.0 0.0037 17.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Glyco_transf_7N PF13733.4 T009648_3 - 5.5e-55 184.5 0.0 1.1e-54 183.6 0.0 1.5 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 CCDC24 PF15669.3 T009648_3 - 6.7e-42 143.5 9.8 5e-39 134.2 0.1 3.1 3 0 0 3 3 3 2 Coiled-coil domain-containing protein 24 family Glyco_transf_7C PF02709.12 T009648_3 - 1.1e-30 105.0 2.8 2e-30 104.1 0.4 2.4 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 T009648_3 - 0.038 13.3 0.0 0.061 12.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 RhoGAP PF00620.25 T015479_3 - 3e-41 140.6 0.7 3e-41 140.6 0.7 2.1 2 0 0 2 2 2 1 RhoGAP domain C1_1 PF00130.20 T015479_3 - 5.7e-07 29.2 7.8 2.3e-06 27.2 7.8 2.1 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) UPAR_LY6 PF00021.19 T353132_1 - 3.8e-12 46.6 11.4 3.8e-12 46.6 11.4 2.4 2 0 0 2 2 2 1 u-PAR/Ly-6 domain Toxin_1 PF00087.19 T353132_1 - 3.4e-06 27.1 9.9 3.4e-06 27.1 9.9 3.6 4 0 0 4 4 4 1 Snake toxin VWC PF00093.16 T332994_1 - 2.4e-27 94.9 129.9 6.5e-10 39.0 11.2 7.9 7 0 0 7 7 7 5 von Willebrand factor type C domain TILa PF12714.5 T332994_1 - 1.7e-05 24.5 21.5 3.2e-05 23.7 2.7 7.8 8 0 0 8 8 8 4 TILa domain CFC PF09443.8 T332994_1 - 2.8 7.8 65.8 0.25 11.1 2.8 7.6 6 0 0 6 6 6 0 Cripto_Frl-1_Cryptic (CFC) VWC PF00093.16 T332994_3 - 4.6e-92 302.1 301.8 7.1e-09 35.7 15.1 15.7 14 1 1 15 15 15 15 von Willebrand factor type C domain VWD PF00094.23 T332994_3 - 2.1e-36 125.4 0.0 3.2e-36 124.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain TILa PF12714.5 T332994_3 - 1.1e-12 47.6 224.2 0.0036 17.1 9.6 15.7 14 1 1 15 15 15 13 TILa domain CFC PF09443.8 T332994_3 - 0.0023 17.6 2.6 0.0023 17.6 2.6 14.7 14 0 0 14 14 14 6 Cripto_Frl-1_Cryptic (CFC) Bestrophin PF01062.19 T081982_1 - 1.6e-85 286.9 1.3 2.3e-85 286.4 1.3 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Tyr_Deacylase PF02580.14 T102539_2 - 0.00047 20.5 0.0 0.00065 20.1 0.0 1.1 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Ig_2 PF13895.4 T018582_1 - 1.8e-20 72.9 0.9 4.5e-09 36.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 T018582_1 - 3.2e-15 56.4 1.1 2.3e-09 37.6 0.7 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 T018582_1 - 3.2e-06 27.1 4.6 0.34 11.0 0.1 3.5 2 2 1 3 3 3 3 Immunoglobulin V-set domain ig PF00047.23 T018582_1 - 0.0008 19.4 0.7 0.13 12.3 0.3 2.7 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 T018582_1 - 0.002 18.0 0.1 0.2 11.6 0.1 2.8 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 T018582_2 - 4e-05 23.6 0.2 0.0033 17.4 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 T018582_2 - 5.1e-05 23.4 0.0 9.1e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 T018582_2 - 0.00069 20.0 0.0 0.0017 18.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain PIRT PF15099.4 T018582_2 - 0.072 12.5 0.3 0.16 11.4 0.3 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family PID PF00640.21 T204523_3 - 6.6e-09 35.8 0.1 9.8e-06 25.5 0.0 2.3 1 1 1 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) bZIP_2 PF07716.13 T204523_3 - 0.0097 15.8 3.9 0.018 15.0 3.9 1.4 1 0 0 1 1 1 1 Basic region leucine zipper PTB PF08416.11 T204523_3 - 0.021 14.9 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotyrosine-binding domain DivIC PF04977.13 T204523_3 - 0.04 13.6 3.9 0.074 12.7 3.9 1.3 1 0 0 1 1 1 0 Septum formation initiator Ax_dynein_light PF10211.7 T204523_3 - 0.046 13.5 0.3 0.081 12.7 0.3 1.3 1 0 0 1 1 1 0 Axonemal dynein light chain Pox_A_type_inc PF04508.10 T204523_3 - 0.089 12.6 0.8 1.6 8.6 0.2 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat IncA PF04156.12 T204523_3 - 0.098 12.3 1.0 0.16 11.6 1.0 1.2 1 0 0 1 1 1 0 IncA protein bZIP_1 PF00170.19 T204523_3 - 0.14 12.2 1.6 0.28 11.2 1.6 1.4 1 0 0 1 1 1 0 bZIP transcription factor TSC22 PF01166.16 T204523_3 - 0.19 12.0 1.3 0.36 11.0 1.3 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family Thioesterase PF00975.18 T037623_3 - 1.4e-36 126.6 0.0 9.5e-33 114.1 0.0 2.1 2 0 0 2 2 2 2 Thioesterase domain Abhydrolase_1 PF00561.18 T037623_3 - 0.00089 18.8 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 T037623_3 - 0.0023 17.1 0.0 0.0037 16.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.5 T037623_3 - 0.025 15.1 0.0 0.062 13.8 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family LIDHydrolase PF10230.7 T037623_3 - 0.081 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Glyco_tran_28_C PF04101.14 T378877_1 - 3.4e-21 75.8 0.0 6.9e-21 74.8 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Drf_GBD PF06371.11 T009846_3 - 0.0019 17.7 1.9 0.0057 16.1 0.5 2.1 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain HEAT_2 PF13646.4 T009846_3 - 0.09 13.0 0.0 0.55 10.5 0.0 2.3 2 1 0 2 2 2 0 HEAT repeats Paired_CXXCH_1 PF09699.8 T380380_1 - 0.27 10.9 3.3 1.9 8.2 0.1 2.6 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Peptidase_M60 PF13402.4 T334956_3 - 1.1e-116 389.9 0.0 1.4e-116 389.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase M60, enhancin and enhancin-like KRAB PF01352.25 T325227_1 - 5.8e-22 77.0 0.5 1.5e-21 75.7 0.5 1.8 1 0 0 1 1 1 1 KRAB box Mid2 PF04478.10 T325227_2 - 0.0014 18.3 0.1 0.0022 17.7 0.1 1.2 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor zf-H2C2_2 PF13465.4 T325227_2 - 0.0023 18.2 0.0 0.0023 18.2 0.0 4.6 5 0 0 5 5 5 1 Zinc-finger double domain zf-H2C2_2 PF13465.4 T325227_3 - 1.3e-87 284.5 150.7 4.8e-07 29.8 0.3 19.3 20 0 0 20 20 20 16 Zinc-finger double domain zf-C2H2 PF00096.24 T325227_3 - 3.5e-55 181.4 121.3 1.2e-05 25.3 2.2 18.9 19 0 0 19 19 19 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T325227_3 - 7.2e-27 91.6 116.7 0.013 16.1 1.9 18.5 18 0 0 18 18 18 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T325227_3 - 4.7e-13 48.6 124.0 0.0032 17.3 0.9 17.8 19 0 0 19 19 19 14 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T325227_3 - 2.4e-11 43.4 100.5 0.035 14.1 3.6 13.4 8 4 7 15 15 15 10 Zinc ribbon domain XPA_N PF01286.16 T325227_3 - 9.8e-11 41.4 80.2 0.92 9.5 0.1 17.4 17 0 0 17 17 17 10 XPA protein N-terminal BolA PF01722.16 T325227_3 - 0.073 13.2 26.5 9.9 6.4 0.0 8.3 6 2 3 10 10 10 0 BolA-like protein zf-C2H2_jaz PF12171.6 T325227_3 - 0.089 13.0 0.1 0.089 13.0 0.1 17.0 17 0 0 17 17 17 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T325227_3 - 1.9 8.2 66.7 4.5 7.0 1.0 15.3 16 0 0 16 16 16 0 zinc-finger C2H2-type MT-A70 PF05063.12 T270302_2 - 1.9e-29 102.6 0.1 2.9e-29 102.1 0.1 1.2 1 0 0 1 1 1 1 MT-A70 MEA1 PF06910.9 T303863_3 - 1.7e-119 395.6 9.1 2.1e-119 395.3 9.1 1.1 1 0 0 1 1 1 1 Male enhanced antigen 1 (MEA1) RasGEF PF00617.17 T174915_3 - 4.2e-39 134.3 0.0 6.7e-39 133.7 0.0 1.2 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 T174915_3 - 1.7e-11 43.7 15.8 1.7e-11 43.7 15.8 2.3 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_7 PF13499.4 T174915_3 - 0.015 15.6 0.0 0.24 11.8 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.4 T174915_3 - 0.042 13.7 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain SAMP PF05924.9 T174915_3 - 0.047 12.8 1.5 0.11 11.7 1.5 1.6 1 0 0 1 1 1 0 SAMP Motif EF-hand_1 PF00036.30 T174915_3 - 0.1 12.1 0.0 0.25 10.8 0.0 1.7 1 0 0 1 1 1 0 EF hand T4_deiodinase PF00837.15 T108007_2 - 4.2e-108 359.9 0.4 1.1e-83 280.1 0.0 2.2 2 0 0 2 2 2 2 Iodothyronine deiodinase Dpy19 PF10034.7 T172934_3 - 9.9e-230 764.0 35.9 2.9e-162 541.1 38.0 2.5 3 0 0 3 3 3 2 Q-cell neuroblast polarisation PSP PF04046.14 T088109_3 - 1.2e-16 60.1 0.1 2.8e-16 59.0 0.1 1.7 1 0 0 1 1 1 1 PSP SMAP PF15477.4 T088109_3 - 5.7e-16 59.1 1.6 5.7e-16 59.1 1.6 2.6 3 0 0 3 3 3 1 Small acidic protein family zf-CCHC PF00098.21 T088109_3 - 0.00011 22.0 3.3 0.00028 20.7 3.3 1.8 1 0 0 1 1 1 1 Zinc knuckle MIP-T3 PF10243.7 T088109_3 - 9.5 4.7 77.9 22 3.5 77.9 1.5 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Peptidase_M1 PF01433.18 T146410_3 - 5.2e-141 470.3 0.1 1.5e-140 468.8 0.1 1.7 1 1 0 1 1 1 1 Peptidase family M1 Shisa PF13908.4 T242158_3 - 2.6e-27 96.1 1.0 5.8e-27 95.0 1.0 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF1725 PF08333.9 T244577_2 - 6.4e-06 25.5 0.8 1.3e-05 24.6 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) PET PF06297.12 T244577_3 - 6e-29 100.0 0.4 6e-29 100.0 0.4 2.0 2 0 0 2 2 2 1 PET Domain LIM PF00412.20 T244577_3 - 2.3e-24 85.2 44.4 1.7e-09 37.6 14.3 3.8 3 0 0 3 3 3 3 LIM domain TMF_TATA_bd PF12325.6 T205302_2 - 0.73 9.9 15.0 0.47 10.5 12.3 1.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding FUSC PF04632.10 T205302_2 - 0.79 8.1 2.6 1.1 7.7 2.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family zf-RING_4 PF14570.4 T333905_3 - 7.1e-20 70.3 12.2 2e-19 68.9 12.2 1.8 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.4 T333905_3 - 6.6e-06 25.8 7.4 6.6e-06 25.8 7.4 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.20 T333905_3 - 2.5e-05 23.9 0.0 5.1e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-UDP PF14569.4 T333905_3 - 0.086 12.8 3.5 0.22 11.6 3.5 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger PH PF00169.27 T068407_3 - 8e-15 55.1 0.1 1.7e-14 54.1 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_3 PF14593.4 T068407_3 - 4.8e-05 23.3 0.8 0.0002 21.3 0.0 2.3 2 0 0 2 2 2 1 PH domain PH_8 PF15409.4 T068407_3 - 0.0001 22.4 0.8 0.00019 21.5 0.1 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.4 T068407_3 - 0.0011 19.2 0.6 0.0033 17.7 0.6 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain WD40_alt PF14077.4 T068407_3 - 0.012 15.3 0.9 0.037 13.8 0.9 1.8 1 0 0 1 1 1 0 Alternative WD40 repeat motif TRIQK PF15168.4 T347760_2 - 7.7e-38 128.1 1.0 1.4e-37 127.3 1.0 1.4 1 0 0 1 1 1 1 Triple QxxK/R motif-containing protein family Peptidase_M3 PF01432.18 T091492_1 - 3.7e-145 484.6 0.0 4.9e-145 484.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 C1q PF00386.19 T091492_1 - 5.9e-36 123.4 0.6 8.9e-36 122.8 0.6 1.3 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 T091492_1 - 4.2e-24 83.9 86.9 2.6e-08 33.4 24.1 4.5 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Peptidase_M91 PF14891.4 T091492_1 - 0.064 13.4 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Effector protein NFRKB_winged PF14465.4 T070362_3 - 6.8e-32 109.6 1.9 2.1e-31 108.0 1.9 1.9 1 0 0 1 1 1 1 NFRKB Winged Helix-like Apt1 PF10351.7 T070362_3 - 0.094 11.4 0.2 0.16 10.7 0.2 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain PSRT PF07636.9 T070362_3 - 0.23 11.0 4.6 0.75 9.4 4.6 1.9 1 0 0 1 1 1 0 PSRT SCAN PF02023.15 T241275_1 - 2.2e-39 133.0 2.2 3.6e-39 132.4 2.2 1.3 1 0 0 1 1 1 1 SCAN domain KRAB PF01352.25 T241275_1 - 4.2e-11 42.2 0.0 8.9e-11 41.2 0.0 1.6 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 T241275_2 - 2.8e-65 213.9 72.2 2.9e-08 33.7 0.6 11.6 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 T241275_2 - 5e-49 162.0 78.9 6e-06 26.3 1.7 11.2 11 0 0 11 11 11 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T241275_2 - 1.4e-24 84.5 64.9 0.028 15.1 0.9 11.4 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T241275_2 - 2.9e-12 46.1 62.4 0.068 13.0 0.2 11.0 10 0 0 10 10 10 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T241275_2 - 1.5e-07 31.3 52.1 0.034 14.1 1.9 7.1 6 1 0 6 6 6 5 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T241275_2 - 7.8e-07 29.1 38.0 0.8 10.0 0.0 10.5 10 0 0 10 10 10 2 Zinc-finger double-stranded RNA-binding DZR PF12773.5 T241275_2 - 0.023 14.6 43.3 13 5.8 6.6 5.9 1 1 2 3 3 3 0 Double zinc ribbon zinc_ribbon_15 PF17032.3 T241275_2 - 0.032 14.8 41.7 4 8.1 2.5 5.9 1 1 4 5 5 5 0 zinc-ribbon family XPA_N PF01286.16 T241275_2 - 1.1 9.2 45.5 15 5.6 0.4 10.3 10 0 0 10 10 10 0 XPA protein N-terminal zf-LYAR PF08790.9 T241275_2 - 3.1 7.7 26.0 0.53 10.1 0.1 7.5 8 0 0 8 8 8 0 LYAR-type C2HC zinc finger Fibrinogen_C PF00147.16 T167558_3 - 6.4e-55 186.2 0.0 9.5e-55 185.7 0.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain SlyX PF04102.10 T167558_3 - 0.31 11.6 6.8 0.19 12.2 4.5 1.8 2 0 0 2 2 2 0 SlyX DivIC PF04977.13 T167558_3 - 1 9.0 2.6 2.3 7.9 2.6 1.5 1 0 0 1 1 1 0 Septum formation initiator NDK PF00334.17 T251220_3 - 2.8e-33 114.7 0.0 8.3e-19 67.8 0.0 2.2 2 0 0 2 2 2 2 Nucleoside diphosphate kinase TTL PF03133.13 T237663_1 - 6.7e-35 120.5 0.0 1e-34 119.9 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ARPC4 PF05856.10 T237663_3 - 4.1e-82 273.6 8.0 5.4e-82 273.2 8.0 1.2 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) TTL PF03133.13 T237663_3 - 1.4e-28 99.8 0.0 2.1e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family Sm_like PF16243.3 T237663_3 - 0.051 13.6 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Sm_like domain RIC3 PF15361.4 T054333_1 - 7.1e-08 32.8 0.5 1.6e-06 28.5 0.4 2.4 2 0 0 2 2 2 1 Resistance to inhibitors of cholinesterase homologue 3 RIC3 PF15361.4 T054333_2 - 1.1e-16 61.4 0.0 2.7e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 GAS PF13851.4 T232040_2 - 0.27 10.4 57.7 0.075 12.3 18.7 2.9 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding FPP PF05911.9 T232040_2 - 1.5 6.8 51.7 0.11 10.5 25.6 2.1 1 1 0 2 2 2 0 Filament-like plant protein, long coiled-coil zf-C4H2 PF10146.7 T232040_2 - 1.6 8.8 20.4 0.068 13.3 1.7 2.6 2 0 0 2 2 2 0 Zinc finger-containing protein Reo_sigmaC PF04582.10 T232040_2 - 6.6 5.9 7.6 3.1 7.0 1.4 2.5 1 1 1 2 2 2 0 Reovirus sigma C capsid protein zf-C2H2 PF00096.24 T356108_2 - 1.1e-06 28.6 32.1 0.019 15.3 1.8 7.2 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-met PF12874.5 T356108_2 - 0.0003 20.9 22.0 0.029 14.6 0.1 5.5 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T356108_2 - 0.029 14.5 16.5 1.8 8.8 1.5 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Radical_SAM PF04055.19 T150412_1 - 1.7e-14 54.4 0.0 2.7e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily HemN_C PF06969.14 T150412_1 - 1.7e-05 24.6 0.7 3.5e-05 23.6 0.7 1.5 1 0 0 1 1 1 1 HemN C-terminal domain AMP-binding PF00501.26 T150412_3 - 7.3e-96 321.2 0.0 9e-96 320.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 T150412_3 - 1.2e-16 61.3 0.1 2.5e-16 60.3 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain zf-C4 PF00105.16 T084334_1 - 4.2e-31 107.1 15.4 9.3e-31 106.0 15.4 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) DUF2318 PF10080.7 T084334_1 - 0.031 14.3 0.2 0.063 13.3 0.2 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Hormone_recep PF00104.28 T084334_3 - 1.2e-27 96.7 3.2 1.8e-27 96.2 3.2 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Pkinase PF00069.23 T289153_2 - 2.9e-10 39.8 0.0 5.3e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain MdcG PF10620.7 T289153_2 - 0.0035 17.0 0.0 0.0061 16.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl-dephospho-CoA transferase MdcG WH1 PF00568.21 T374445_3 - 1e-42 144.4 0.0 1.4e-42 144.0 0.0 1.2 1 0 0 1 1 1 1 WH1 domain PBD PF00786.26 T374445_3 - 6e-17 61.7 0.0 1.4e-16 60.5 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain WH2 PF02205.18 T374445_3 - 1.2e-08 34.4 0.2 2.7e-08 33.3 0.2 1.6 1 0 0 1 1 1 1 WH2 motif Phe_ZIP PF08916.9 T129614_1 - 1.3e-21 77.0 6.6 2.2e-21 76.2 6.6 1.4 1 0 0 1 1 1 1 Phenylalanine zipper SH2 PF00017.22 T129614_1 - 5.4e-14 51.9 0.2 8.5e-14 51.2 0.2 1.3 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 T129614_1 - 7.1e-13 48.8 0.0 1.3e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 PH domain E1-E2_ATPase PF00122.18 T129614_2 - 1e-63 214.5 0.9 1e-63 214.5 0.9 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 T129614_2 - 9.7e-44 149.1 1.0 1.6e-43 148.4 1.0 1.3 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 T129614_2 - 2.4e-19 69.1 0.4 4e-19 68.4 0.4 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 T129614_2 - 3.6e-19 68.0 0.6 8.4e-19 66.9 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 T129614_2 - 1.6e-17 64.4 0.2 5.3e-17 62.7 0.2 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 T129614_2 - 2.1e-05 24.3 0.6 3.1e-05 23.7 0.6 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 T129614_2 - 0.05 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Glyco_transf_29 PF00777.16 T122369_2 - 1.7e-23 83.3 0.3 2.2e-23 82.8 0.3 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Pkinase PF00069.23 T152091_2 - 3.4e-67 226.5 0.0 4.5e-67 226.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T152091_2 - 3e-40 138.0 0.0 4.7e-40 137.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 T152091_2 - 3.8e-12 45.8 0.3 6.8e-12 45.0 0.3 1.4 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.4 T152091_2 - 0.00014 21.2 0.0 0.0026 17.0 0.0 2.4 1 1 1 2 2 2 1 Kinase-like DUF3338 PF11819.6 T037438_2 - 7.7e-52 174.8 10.2 3.6e-51 172.6 10.2 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3338) FERM_C PF09380.8 T037438_2 - 1.4e-12 47.7 0.7 3e-12 46.6 0.7 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain DUF1725 PF08333.9 T037438_2 - 0.00055 19.4 1.3 0.0012 18.3 1.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Utp13 PF08625.9 T125208_2 - 2e-39 134.5 1.5 2.7e-39 134.1 1.5 1.2 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.30 T125208_2 - 4.8e-08 33.4 1.5 0.0022 18.6 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat UTP15_C PF09384.8 T125208_2 - 0.0016 18.1 1.5 0.0025 17.5 1.5 1.2 1 0 0 1 1 1 1 UTP15 C terminal ANAPC4_WD40 PF12894.5 T125208_2 - 0.071 13.3 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 T125208_3 - 4.7e-42 141.0 28.8 2.8e-07 31.0 0.2 10.2 10 1 1 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T125208_3 - 4.4e-13 49.2 0.5 0.57 10.4 0.0 7.2 3 2 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T125208_3 - 0.0013 17.7 0.1 2.4 6.9 0.0 3.6 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 T125208_3 - 0.01 14.3 0.9 31 2.9 0.0 4.1 4 0 0 4 4 4 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.9 T125208_3 - 0.037 12.6 0.0 7.4 5.1 0.0 2.8 2 1 0 2 2 2 0 Nup133 N terminal like Urotensin_II PF02083.13 T257068_1 - 0.00041 19.7 4.2 0.00041 19.7 4.2 2.9 3 0 0 3 3 3 1 Urotensin II GYF PF02213.14 T329800_2 - 1.1e-19 69.8 0.2 1.8e-19 69.0 0.2 1.4 1 0 0 1 1 1 1 GYF domain DUF4339 PF14237.4 T329800_2 - 0.0051 16.5 0.1 0.014 15.1 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4339) PRTase_3 PF15610.4 T329800_2 - 0.18 10.9 0.0 0.27 10.3 0.0 1.1 1 0 0 1 1 1 0 PRTase ComF-like Septin PF00735.16 T151469_1 - 1.7e-127 424.3 0.0 2.3e-127 423.9 0.0 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 T151469_1 - 2.7e-06 27.3 0.0 4.9e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 T151469_1 - 1.2e-05 25.1 0.0 0.00078 19.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 T151469_1 - 0.0045 16.4 0.1 0.61 9.5 0.0 2.7 2 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AIG1 PF04548.14 T151469_1 - 0.02 14.1 0.0 0.042 13.0 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Dynamin_N PF00350.21 T151469_1 - 0.054 13.4 0.2 5.8 6.8 0.0 2.5 1 1 1 2 2 2 0 Dynamin family AAA_16 PF13191.4 T151469_1 - 0.086 13.1 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.4 T151469_1 - 0.16 11.6 0.1 0.33 10.6 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain CLASP_N PF12348.6 T198153_1 - 6.7e-53 179.5 17.0 1.6e-39 135.7 0.6 5.2 6 0 0 6 6 6 2 CLASP N terminal HEAT PF02985.20 T198153_1 - 1.6e-15 55.7 11.6 2.6e-05 23.9 0.0 8.9 10 0 0 10 10 9 3 HEAT repeat Cnd1 PF12717.5 T198153_1 - 3.5e-08 33.5 2.7 0.0045 16.9 0.8 5.1 4 1 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 T198153_1 - 8.1e-08 32.4 2.8 0.066 13.6 0.0 5.6 5 0 0 5 5 5 1 HEAT-like repeat HEAT_2 PF13646.4 T198153_1 - 1.4e-07 31.7 6.8 0.18 12.1 0.0 6.9 5 2 4 10 10 10 4 HEAT repeats Sec7_N PF12783.5 T198153_1 - 1.9e-07 31.1 0.1 0.0077 16.1 0.0 4.3 3 0 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Vac14_Fab1_bd PF12755.5 T198153_1 - 2.3e-05 24.8 1.2 2.7 8.5 0.0 5.0 6 0 0 6 6 5 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.18 T198153_1 - 9.2e-05 21.0 3.2 2.5 6.4 0.0 4.9 4 2 0 6 6 6 2 Adaptin N terminal region RTP1_C1 PF10363.7 T198153_1 - 0.00056 19.9 2.4 0.71 9.9 0.3 4.6 4 1 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 ParcG PF10274.7 T198153_1 - 0.0048 16.9 2.0 0.067 13.2 0.2 3.5 2 1 1 3 3 3 1 Parkin co-regulated protein TFCD_C PF12612.6 T198153_1 - 0.0073 16.1 0.9 0.091 12.5 0.2 3.0 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal MMS19_N PF14500.4 T198153_1 - 0.012 15.1 2.8 1.4 8.2 0.1 3.8 4 0 0 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II TAN PF11640.6 T198153_1 - 0.08 13.0 5.0 0.19 11.8 0.1 3.6 4 0 0 4 4 4 0 Telomere-length maintenance and DNA damage repair Ipi1_N PF12333.6 T198153_1 - 3.9 8.0 5.9 3.6 8.2 0.1 3.7 4 0 0 4 4 3 0 Rix1 complex component involved in 60S ribosome maturation AlbA_2 PF04326.12 T008947_1 - 1.8e-20 73.3 0.0 2.9e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 Putative DNA-binding domain MBT PF02820.16 T008947_3 - 1.2e-47 160.0 0.0 9.9e-25 86.6 0.0 2.5 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 T008947_3 - 1.7e-35 121.7 0.1 3.1e-35 120.9 0.1 1.4 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.28 T008947_3 - 6.2e-16 58.5 0.1 1e-15 57.8 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.1 T008947_3 - 7.6e-12 45.7 17.6 7.6e-12 45.7 17.6 2.6 2 0 0 2 2 2 1 RNA binding Region SAM_2 PF07647.15 T008947_3 - 8.8e-07 28.8 0.0 1.6e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 T008947_3 - 0.0058 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain MHC_I_3 PF16497.3 T023023_1 - 6.6e-29 100.7 0.1 1.4e-28 99.6 0.0 1.5 2 0 0 2 2 2 1 MHC-I family domain C1-set PF07654.13 T023023_1 - 7.5e-10 39.0 0.0 1.6e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 T023023_1 - 0.12 12.8 0.1 1.4 9.4 0.0 2.2 1 1 1 2 2 2 0 Immunoglobulin domain MHC_I PF00129.16 T023023_1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 I-set PF07679.14 T121589_1 - 9.6e-20 70.3 0.0 5.8e-10 39.0 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain TPKR_C2 PF16920.3 T121589_1 - 4.5e-19 68.2 7.3 1.4e-18 66.6 7.3 1.9 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain ig PF00047.23 T121589_1 - 9.3e-18 64.1 0.4 5.1e-15 55.3 0.3 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 T121589_1 - 2.8e-17 63.0 1.5 1.3e-09 38.4 0.9 2.6 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.4 T121589_1 - 5.2e-13 48.4 2.3 5.2e-13 48.4 2.3 1.9 2 0 0 2 2 2 1 Leucine rich repeat Ig_2 PF13895.4 T121589_1 - 3.7e-12 46.3 1.1 6.6e-07 29.5 0.3 2.6 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 T121589_1 - 3e-08 33.5 0.5 0.001 18.9 0.1 2.4 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain LRRNT PF01462.16 T121589_1 - 1.7e-06 27.4 2.2 6.7e-06 25.5 2.2 2.1 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.4 T121589_1 - 0.00013 21.7 0.9 0.00026 20.8 0.9 1.4 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_4 PF12799.5 T121589_1 - 0.00015 21.9 8.0 0.0017 18.5 0.8 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 T121589_1 - 0.11 12.4 0.3 0.59 10.2 0.3 2.3 1 0 0 1 1 1 0 Leucine Rich repeat LRR_1 PF00560.31 T121589_1 - 3.4 8.4 7.6 12 6.7 0.2 5.3 6 0 0 6 6 5 0 Leucine Rich Repeat Fucokinase PF07959.10 T135493_1 - 2.9e-56 191.1 0.0 3.7e-56 190.8 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase GHMP_kinases_C PF08544.11 T135493_1 - 1.4e-05 25.2 0.0 3.3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.24 T135493_1 - 2.8e-05 24.1 0.5 9.2e-05 22.5 0.5 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain RhoGEF PF00621.18 T022263_1 - 2.8e-29 102.5 0.3 4.3e-29 101.9 0.3 1.3 1 0 0 1 1 1 1 RhoGEF domain C1_1 PF00130.20 T022263_1 - 2e-05 24.2 3.7 6.5e-05 22.6 3.7 1.9 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 T022263_1 - 0.00039 20.8 0.0 0.0008 19.8 0.0 1.5 1 0 0 1 1 1 1 PH domain C1_2 PF03107.14 T022263_1 - 0.00068 19.8 1.4 0.0018 18.4 1.4 1.7 1 0 0 1 1 1 1 C1 domain Prok-RING_1 PF14446.4 T022263_1 - 0.0048 16.7 5.4 0.016 15.0 5.4 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 SAM_1 PF00536.28 T075773_2 - 1.4e-37 127.8 10.4 5.8e-17 61.7 0.2 3.8 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T075773_2 - 4.2e-32 109.9 5.8 1e-13 51.0 0.0 3.8 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) DUF16 PF01519.14 T075773_2 - 0.0012 19.1 1.4 0.0012 19.1 1.4 2.8 2 1 0 2 2 2 1 Protein of unknown function DUF16 SAM_PNT PF02198.14 T075773_2 - 0.048 13.5 2.2 4 7.3 0.1 3.0 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain ADIP PF11559.6 T075773_2 - 0.51 10.3 22.6 0.2 11.6 8.6 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.4 T075773_2 - 0.87 8.7 14.9 16 4.6 13.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF3837 PF12939.5 T075773_2 - 4.5 7.6 11.0 0.044 14.1 1.0 2.7 3 1 1 4 4 4 0 Domain of unknown function (DUF3837) RNase_P_Rpp14 PF01900.17 T087700_1 - 0.00028 21.0 0.0 0.0044 17.1 0.0 2.1 1 1 1 2 2 2 1 Rpp14/Pop5 family C2 PF00168.28 T059796_3 - 5.7e-52 174.2 1.8 9.4e-26 90.0 0.1 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.4 T059796_3 - 0.12 11.9 0.0 0.3 10.5 0.0 1.6 2 0 0 2 2 2 0 CEP76 C2 domain Copine PF07002.14 T138700_1 - 1.5e-89 299.1 0.0 4.4e-84 281.2 0.0 2.1 2 0 0 2 2 2 2 Copine C2 PF00168.28 T138700_1 - 1.3e-14 54.1 0.0 2.8e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain vWA-TerF-like PF10138.7 T138700_1 - 0.00063 19.8 0.0 0.001 19.1 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.26 T138700_1 - 0.0012 19.0 0.0 0.002 18.3 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain C2 PF00168.28 T138700_3 - 5.9e-11 42.4 0.0 1.1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 C2 domain Pkinase PF00069.23 T211697_2 - 6.8e-70 235.3 0.0 8.5e-70 235.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T211697_2 - 2.9e-51 174.1 0.0 4.5e-51 173.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1241 PF06840.9 T211697_2 - 0.00036 20.1 0.0 0.0007 19.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Kinase-like PF14531.4 T211697_2 - 0.016 14.4 0.0 0.046 12.9 0.0 1.7 2 0 0 2 2 2 0 Kinase-like PHD PF00628.27 T235093_3 - 5.5e-06 26.0 5.6 5.5e-06 26.0 5.6 2.9 2 0 0 2 2 2 1 PHD-finger Dimer_Tnp_hAT PF05699.12 T370620_2 - 8.1e-15 54.3 0.0 2.3e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-BED PF02892.13 T370620_2 - 7.5e-14 51.4 0.9 7.5e-14 51.4 0.9 2.0 2 0 0 2 2 2 1 BED zinc finger DUF4413 PF14372.4 T370620_2 - 0.00018 21.6 0.1 0.00045 20.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) PH PF00169.27 T302315_1 - 3.5e-18 65.9 0.2 5.9e-18 65.2 0.2 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 T302315_1 - 0.001 19.2 0.0 0.0019 18.3 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 T302315_1 - 0.0029 17.9 1.5 0.023 15.0 1.5 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.8 T302315_1 - 0.0068 16.6 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Plant pleckstrin homology-like region EF-hand_6 PF13405.4 T302315_1 - 0.2 11.5 0.0 0.47 10.4 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain MVL PF12151.6 T302315_1 - 1 9.1 4.6 2.1 8.1 0.3 2.8 2 0 0 2 2 2 0 Mannan-binding protein zf-H2C2_2 PF13465.4 T302315_2 - 5.7e-27 92.8 50.7 1.8e-08 34.3 1.4 8.4 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 T302315_2 - 5.5e-19 67.4 65.3 7.6e-05 22.8 0.4 9.6 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T302315_2 - 5e-12 45.4 50.2 0.006 17.2 0.4 9.3 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T302315_2 - 5.5e-05 23.2 4.0 0.95 9.7 0.1 4.7 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding CopK PF11525.6 T302315_2 - 0.21 11.1 0.1 50 3.5 0.0 3.4 3 1 1 4 4 4 0 Copper resistance protein K zf-C2H2_aberr PF17017.3 T302315_2 - 0.76 9.8 18.3 6.9 6.6 0.2 4.8 3 1 2 5 5 5 0 Aberrant zinc-finger zf-C2H2_6 PF13912.4 T302315_2 - 4 7.4 22.4 1.1 9.2 0.7 5.2 5 0 0 5 5 5 0 C2H2-type zinc finger zf-CXXC PF02008.18 T162100_1 - 1.1e-33 114.8 73.4 1.7e-12 47.0 26.0 4.4 3 0 0 3 3 3 3 CXXC zinc finger domain TPH PF13868.4 T162100_1 - 3.8e-17 61.7 135.6 3.8e-17 61.7 135.6 2.3 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain MBD PF01429.17 T162100_1 - 1.3e-15 56.7 0.0 3.1e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain zf-CpG_bind_C PF12269.6 T162100_3 - 1e-103 346.1 6.7 2.4e-103 344.9 6.7 1.7 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain zf-CXXC PF02008.18 T162100_3 - 2.3e-16 59.4 20.4 9.9e-16 57.4 20.4 2.2 1 0 0 1 1 1 1 CXXC zinc finger domain PHD PF00628.27 T162100_3 - 5.3e-10 38.9 11.9 5.3e-10 38.9 11.9 3.4 4 0 0 4 4 4 1 PHD-finger zf-Tim10_DDP PF02953.13 T058932_1 - 1.6e-21 75.5 0.7 3e-21 74.7 0.7 1.5 1 0 0 1 1 1 1 Tim10/DDP family zinc finger MFS_1 PF07690.14 T058932_1 - 3e-14 52.6 13.8 3e-14 52.6 13.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily UQ_con PF00179.24 T058932_3 - 9.3e-40 135.4 0.4 1.4e-39 134.8 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 T058932_3 - 0.0082 16.3 0.3 0.014 15.6 0.3 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.4 T058932_3 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B Nucleoside_tran PF01733.16 T061638_2 - 7.9e-38 130.4 1.3 1.2e-37 129.8 1.3 1.2 1 0 0 1 1 1 1 Nucleoside transporter DUF2070 PF09843.7 T061638_2 - 4 5.5 12.7 6.2 4.8 12.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Nucleoside_tran PF01733.16 T061638_3 - 8.6e-80 268.3 0.4 1.2e-79 267.8 0.4 1.1 1 0 0 1 1 1 1 Nucleoside transporter DUF4519 PF15012.4 T349250_2 - 0.16 12.0 4.2 0.47 10.5 4.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) SAM_1 PF00536.28 T075820_1 - 8.2e-38 128.5 10.4 5e-17 62.0 0.2 3.9 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T075820_1 - 2.5e-32 110.7 5.8 8.7e-14 51.2 0.0 3.9 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) DUF16 PF01519.14 T075820_1 - 0.001 19.4 1.4 0.001 19.4 1.4 3.4 2 1 0 2 2 2 1 Protein of unknown function DUF16 SAM_PNT PF02198.14 T075820_1 - 0.033 14.0 2.2 3.5 7.5 0.1 3.0 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain DUF4407 PF14362.4 T075820_1 - 0.37 10.0 17.4 4.3 6.5 15.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Ank_2 PF12796.5 T332318_2 - 1.1e-37 128.3 15.3 6.9e-11 42.5 0.0 4.5 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T332318_2 - 1.6e-26 92.2 5.9 5e-06 26.8 0.0 5.7 6 0 0 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 T332318_2 - 1.3e-24 83.4 8.2 0.0024 18.1 0.4 9.0 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.4 T332318_2 - 1.1e-18 66.8 11.5 1.2e-05 25.4 0.2 6.2 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.28 T332318_2 - 5.2e-17 61.3 16.6 0.018 15.4 0.1 8.0 8 0 0 8 8 8 6 Ankyrin repeat SOCS_box PF07525.14 T332318_2 - 6.6e-11 42.2 6.9 6.6e-11 42.2 6.9 2.2 2 0 0 2 2 2 1 SOCS box Ank_2 PF12796.5 T332318_3 - 0.017 15.5 0.0 0.035 14.6 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) C2 PF00168.28 T349075_2 - 1.6e-36 124.6 0.0 5.8e-19 68.2 0.0 2.4 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 T349075_2 - 6.5e-10 39.1 10.2 1.4e-09 38.0 10.2 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger PDZ PF00595.22 T349075_2 - 1.5e-05 25.1 0.0 2.9e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Gar1 PF04410.12 T269519_2 - 2.4e-37 128.0 0.0 3.6e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Pkinase PF00069.23 T144439_2 - 5e-63 212.8 0.0 7.1e-63 212.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T144439_2 - 4.5e-30 104.7 0.0 6.4e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T144439_2 - 0.049 12.8 0.0 0.085 12.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.4 T144439_2 - 0.11 12.0 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 zf-LYAR PF08790.9 T248857_2 - 0.13 12.1 2.2 2.1 8.2 0.1 2.8 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Mito_fiss_reg PF05308.9 T345136_3 - 2.4e-82 276.6 2.0 3.4e-82 276.1 2.0 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator PRIMA1 PF16101.3 T345136_3 - 0.22 11.4 3.5 0.45 10.4 3.5 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 FlxA PF14282.4 T345136_3 - 1.4 8.9 5.0 2.5 8.0 5.0 1.3 1 0 0 1 1 1 0 FlxA-like protein PRIMA1 PF16101.3 T203920_2 - 8.1 6.4 12.7 14 5.6 12.7 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-met PF12874.5 T203920_3 - 1.3e-05 25.3 0.6 2.8e-05 24.2 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T203920_3 - 0.00013 22.0 0.3 0.00029 20.9 0.3 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF4764 PF15961.3 T370771_2 - 8.6e-102 342.1 6.2 1.9e-89 301.3 1.5 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4764) DUF4764 PF15961.3 T370771_3 - 1.1e-13 50.7 8.9 7.9e-07 28.0 1.3 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4764) Hydrolase_like PF13242.4 T161775_3 - 2.6e-17 62.5 0.0 4.6e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.4 T161775_3 - 2.2e-08 34.0 0.0 3.8e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 T161775_3 - 9.1e-05 22.5 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 T161775_3 - 0.024 14.8 0.0 0.035 14.3 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase zf-RING_2 PF13639.4 T336840_1 - 9.5e-09 35.3 6.8 9.5e-09 35.3 6.8 2.7 3 0 0 3 3 2 1 Ring finger domain zf-RING_UBOX PF13445.4 T336840_1 - 1.1e-08 34.7 5.7 4.3e-08 32.9 5.7 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 T336840_1 - 5.5e-07 29.3 7.1 2.7e-06 27.1 7.1 2.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.5 T336840_1 - 2.6e-06 27.5 4.3 1e-05 25.6 4.3 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 T336840_1 - 7.9e-06 25.5 8.1 3.7e-05 23.4 8.1 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T336840_1 - 2.8e-05 23.8 7.7 2.8e-05 23.8 7.7 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 T336840_1 - 8.5e-05 22.4 4.6 0.00011 22.1 2.7 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.4 T336840_1 - 0.00011 21.9 5.2 0.00011 21.9 5.2 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) IQ PF00612.25 T336840_1 - 0.00024 20.5 3.2 0.00058 19.3 3.2 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif zf-RING_11 PF17123.3 T336840_1 - 0.0006 19.3 4.0 0.0006 19.3 4.0 2.3 2 0 0 2 2 1 1 RING-like zinc finger Zn_ribbon_17 PF17120.3 T336840_1 - 0.013 15.0 3.0 0.054 13.0 3.0 2.0 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.4 T336840_1 - 0.11 12.2 5.2 0.34 10.5 5.2 2.0 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.4 T336840_1 - 0.17 11.6 17.9 0.013 15.2 8.1 3.8 3 1 1 4 4 4 0 Prokaryotic RING finger family 4 zf-Nse PF11789.6 T336840_1 - 0.2 11.4 5.3 0.63 9.8 5.3 1.9 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.4 T336840_1 - 0.22 11.6 6.9 0.74 9.9 6.9 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING BDV_P40 PF06407.9 T038241_2 - 1.1e-74 251.6 0.0 1.6e-74 251.1 0.0 1.1 1 0 0 1 1 1 1 Borna disease virus P40 protein Hormone_recep PF00104.28 T058091_2 - 8.7e-29 100.5 1.8 1.2e-28 100.0 1.8 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DENN PF02141.19 T058091_3 - 3.1e-33 115.2 1.5 6.4e-33 114.1 1.5 1.6 1 1 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 T058091_3 - 4.5e-18 65.7 0.6 1.5e-17 64.0 0.6 2.0 1 0 0 1 1 1 1 uDENN domain Transposase_22 PF02994.12 T119111_1 - 6.6e-17 61.3 10.0 1.2e-14 53.8 0.1 2.6 3 0 0 3 3 3 2 L1 transposable element RRM_1 PF00076.20 T119111_3 - 1e-47 159.7 0.0 6.2e-16 57.9 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T119111_3 - 0.031 14.3 0.1 5.5 7.1 0.0 3.2 3 0 0 3 3 3 0 RNA recognition motif A2M_comp PF07678.12 T365861_1 - 9.2e-65 218.4 0.2 1.4e-64 217.8 0.2 1.3 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_N_2 PF07703.12 T365861_1 - 1.8e-27 96.2 0.2 2.8e-26 92.4 0.0 2.8 2 1 1 3 3 3 1 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 T365861_1 - 6.7e-27 93.0 0.1 2.2e-26 91.4 0.1 2.0 1 0 0 1 1 1 1 Alpha-2-macroglobulin family NTR PF01759.19 T365861_1 - 3.5e-24 84.5 0.2 7.5e-24 83.5 0.2 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module A2M_recep PF07677.12 T365861_1 - 1e-22 80.5 0.1 5.3e-22 78.3 0.0 2.3 2 0 0 2 2 2 1 A-macroglobulin receptor TRAF_BIRC3_bd PF16673.3 T365861_1 - 3.5e-16 58.6 1.4 5e-15 54.9 3.2 2.0 2 0 0 2 2 2 1 TNF receptor-associated factor BIRC3 binding domain A2M_N PF01835.17 T365861_1 - 6.5e-15 55.2 0.0 4.9e-13 49.2 0.0 2.9 2 0 0 2 2 2 1 MG2 domain ANATO PF01821.16 T365861_1 - 2.4e-08 34.5 11.2 7.4e-08 33.0 11.2 1.9 1 0 0 1 1 1 1 Anaphylotoxin-like domain DUF4369 PF14289.4 T365861_1 - 0.0027 18.2 0.0 0.011 16.2 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4369) MFS_1 PF07690.14 T129683_1 - 1.2e-32 113.1 24.1 1.2e-32 113.1 24.1 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 T129683_1 - 3.8e-13 49.0 3.3 3.8e-13 49.0 3.3 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.18 T129683_1 - 6.2e-09 34.6 13.6 0.00047 18.5 0.3 4.1 2 2 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.4 T129683_1 - 2.2e-07 29.7 2.0 0.0043 15.5 0.0 2.5 1 1 1 2 2 2 2 MFS/sugar transport protein MFS_4 PF06779.12 T129683_1 - 0.00057 19.2 1.7 0.0011 18.2 1.7 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB PTR2 PF00854.19 T129683_1 - 0.16 10.7 1.6 0.25 10.0 1.6 1.2 1 0 0 1 1 1 0 POT family LAT PF15234.4 T129683_3 - 3.4e-118 393.6 10.9 4.9e-118 393.1 10.9 1.2 1 0 0 1 1 1 1 Linker for activation of T-cells LAX PF15681.3 T129683_3 - 0.89 8.0 3.9 1.7 7.1 3.9 1.4 1 1 0 1 1 1 0 Lymphocyte activation family X TFR_dimer PF04253.13 T060993_1 - 4.2e-24 84.8 0.0 2.2e-23 82.5 0.0 1.9 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain Metallophos PF00149.26 T340327_2 - 4.9e-38 131.6 0.0 7.2e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PTEN_C2 PF10409.7 T340327_2 - 0.1 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein Torsin PF06309.9 T367609_2 - 3e-48 163.0 0.1 4.6e-48 162.4 0.1 1.3 1 0 0 1 1 1 1 Torsin AAA PF00004.27 T367609_2 - 0.00036 20.8 0.0 0.00056 20.2 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.16 T367609_2 - 0.03 13.9 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_2 PF07724.12 T367609_2 - 0.063 13.3 0.0 0.092 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) GPS2_interact PF15784.3 T142451_2 - 5.9e-35 119.7 6.8 5.9e-35 119.7 6.8 4.4 3 0 0 3 3 3 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 T142451_2 - 1.1e-17 63.8 0.2 6.1e-12 45.4 0.2 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T142451_2 - 0.0072 16.4 1.9 0.094 12.8 0.3 2.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Lectin_C PF00059.19 T018501_2 - 6.6e-18 65.3 4.1 1e-17 64.7 4.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain RcnB PF11776.6 T018501_2 - 0.19 11.7 3.7 6.4 6.8 0.1 2.4 2 0 0 2 2 2 0 Nickel/cobalt transporter regulator zf-C2H2 PF00096.24 T380781_2 - 4.5e-09 36.1 12.9 1.3e-05 25.2 3.0 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T380781_2 - 5.4e-05 23.3 16.9 0.0053 17.0 5.1 4.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.5 T380781_2 - 0.0015 18.7 1.2 0.0015 18.7 1.2 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 T380781_2 - 0.002 17.9 1.1 0.0055 16.5 1.1 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.4 T380781_2 - 0.0061 17.2 1.8 0.0061 17.2 1.8 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T380781_2 - 0.0075 16.4 7.5 0.031 14.4 0.2 3.5 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding COX7C PF02935.14 T380781_2 - 0.074 13.2 0.5 1.5 8.9 0.9 2.7 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc zf-C2H2 PF00096.24 T380781_3 - 3.6e-10 39.6 10.9 0.00011 22.3 0.2 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T380781_3 - 2.8e-06 27.4 0.3 2.8e-06 27.4 0.3 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.4 T380781_3 - 0.11 13.3 0.2 0.11 13.3 0.2 4.7 4 0 0 4 4 4 0 C2H2-type zinc finger PE PF00934.18 T380781_3 - 0.12 12.6 4.7 0.22 11.7 4.7 1.3 1 0 0 1 1 1 0 PE family KxDL PF10241.7 T170715_1 - 3e-29 101.0 2.0 4.5e-29 100.4 2.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein ubiquitin PF00240.21 T170715_2 - 4.9e-33 112.5 0.3 7.7e-33 111.9 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.15 T170715_2 - 1.8e-31 107.6 12.3 4.3e-31 106.4 12.3 1.7 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.6 T170715_2 - 4.2e-15 55.2 0.4 6.2e-15 54.6 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 T170715_2 - 0.00053 20.2 0.1 0.00092 19.5 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain DUF4918 PF16265.3 T079671_3 - 0.0021 17.5 0.0 0.013 14.9 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4918) Glyco_hydro_38 PF01074.20 T122183_3 - 1.2e-106 356.1 0.3 1.8e-106 355.6 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.11 T122183_3 - 1.4e-84 284.7 0.0 2.1e-84 284.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.9 T122183_3 - 5.2e-24 84.3 0.0 1.3e-23 83.1 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain PLAC8 PF04749.15 T267381_2 - 3.5e-12 47.0 21.8 3.5e-12 47.0 21.8 2.1 2 0 0 2 2 2 1 PLAC8 family Sugar_tr PF00083.22 T366768_2 - 5.5e-62 210.0 12.8 1.1e-61 209.0 12.8 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 T366768_2 - 2.3e-07 30.0 23.6 4.1e-07 29.1 23.6 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Syncollin PF15138.4 T175144_3 - 3.1e-54 181.8 0.5 5.4e-54 181.0 0.5 1.4 1 0 0 1 1 1 1 Syncollin PalH PF08733.8 T175144_3 - 0.014 14.3 1.8 0.026 13.4 1.8 1.3 1 0 0 1 1 1 0 PalH/RIM21 Ank_2 PF12796.5 T244008_1 - 0.0065 16.9 0.0 0.01 16.3 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 T244008_1 - 0.014 15.7 0.1 0.028 14.7 0.1 1.6 1 0 0 1 1 1 0 Ankyrin repeat Ank_4 PF13637.4 T244008_1 - 0.058 13.9 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.4 T244008_1 - 0.075 13.5 0.1 0.17 12.4 0.1 1.6 1 0 0 1 1 1 0 Ankyrin repeat Ig_2 PF13895.4 T180629_2 - 1.6e-08 34.6 0.0 2.9e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T180629_2 - 3.8e-05 23.6 0.0 6.7e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 T180629_2 - 0.00014 22.2 0.0 0.00026 21.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain PHD PF00628.27 T152959_1 - 2.6e-26 91.1 49.9 1.2e-09 37.8 6.8 4.5 4 0 0 4 4 4 3 PHD-finger Bromodomain PF00439.23 T152959_1 - 2.8e-25 88.1 0.2 5.6e-25 87.1 0.2 1.6 1 0 0 1 1 1 1 Bromodomain DDT PF02791.15 T152959_1 - 4.6e-17 62.0 0.3 9.5e-17 60.9 0.3 1.6 1 0 0 1 1 1 1 DDT domain WSD PF15613.4 T152959_1 - 2.1e-08 34.4 1.8 2.1e-08 34.4 1.8 5.2 6 1 0 6 6 6 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif WHIM1 PF15612.4 T152959_1 - 0.00022 20.6 0.0 0.00075 18.9 0.0 1.9 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 Arc_PepC_II PF06847.9 T152959_1 - 0.24 11.8 1.8 1.6 9.1 0.6 3.1 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II HLH PF00010.24 T319452_2 - 8.3e-16 57.6 0.7 1.8e-15 56.5 0.7 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain LRR19-TM PF15176.4 T009390_1 - 5.8e-22 77.6 2.6 1.8e-19 69.5 2.6 2.2 1 1 0 1 1 1 1 Leucine-rich repeat family 19 TM domain MHC_I PF00129.16 T178815_2 - 3.1e-42 144.0 0.0 4.4e-42 143.5 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 T178815_2 - 4.4e-08 33.4 0.0 8e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 T178815_2 - 0.0016 17.8 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain EF-hand_1 PF00036.30 T178815_3 - 3.3e-14 51.1 0.1 0.012 15.0 0.0 6.0 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.4 T178815_3 - 1.1e-13 51.2 2.9 0.00069 19.9 0.5 3.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.4 T178815_3 - 5.3e-13 47.6 0.9 0.16 11.8 0.0 6.3 6 0 0 6 6 6 5 EF-hand domain EF-hand_5 PF13202.4 T178815_3 - 2.3e-08 33.0 10.1 0.42 10.1 0.1 6.2 6 0 0 6 6 6 3 EF hand EF-hand_8 PF13833.4 T178815_3 - 6.6e-07 28.9 2.9 0.044 13.4 0.0 4.3 5 0 0 5 5 5 3 EF-hand domain pair C2 PF00168.28 T086755_1 - 2.7e-40 136.7 0.0 5.7e-19 68.2 0.0 2.4 2 0 0 2 2 2 2 C2 domain RasGAP PF00616.17 T086755_1 - 4.9e-39 134.1 0.0 7.7e-39 133.4 0.0 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase PH PF00169.27 T086755_1 - 3.2e-15 56.4 0.0 1.5e-14 54.2 0.0 2.0 2 0 0 2 2 2 1 PH domain BTK PF00779.17 T086755_1 - 2.8e-07 30.1 5.1 4.9e-07 29.3 0.9 2.7 2 0 0 2 2 2 1 BTK motif Pkinase_Tyr PF07714.15 T310348_3 - 9.9e-96 319.9 0.0 1.6e-95 319.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase fn3 PF00041.19 T310348_3 - 2.1e-48 162.5 25.4 2.2e-09 37.4 0.0 9.9 9 0 0 9 9 9 9 Fibronectin type III domain Pkinase PF00069.23 T310348_3 - 8.1e-39 133.4 0.0 1.4e-38 132.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pur_ac_phosph_N PF16656.3 T310348_3 - 0.037 14.5 10.7 2.8 8.4 3.4 5.4 4 1 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.3 T310348_3 - 0.15 11.9 0.3 1.6 8.5 0.0 3.0 4 0 0 4 4 4 0 Fibronectin-III type domain TTL PF03133.13 T107596_2 - 2e-91 306.1 0.1 4.7e-91 304.8 0.1 1.6 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 T107596_2 - 1.6e-06 27.4 0.0 0.0035 16.5 0.0 2.5 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 T107596_2 - 0.0027 16.9 0.0 0.32 10.1 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp Sec23_trunk PF04811.13 T269479_2 - 1.3e-85 286.8 0.1 1.8e-85 286.3 0.1 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.13 T269479_2 - 2.5e-27 94.6 2.1 4.8e-27 93.7 2.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.10 T269479_2 - 1.3e-20 73.8 0.0 2.5e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.13 T269479_2 - 1.8e-14 53.4 5.2 4.3e-14 52.1 5.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 T269479_2 - 5.8e-12 45.2 0.0 1.2e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Sen15 PF09631.8 T269479_2 - 0.062 13.5 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Sen15 protein DUF4586 PF15239.4 T275777_2 - 5.3e-67 227.0 12.1 6.5e-67 226.7 12.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) DUF4586 PF15239.4 T275777_3 - 1e-06 29.0 0.4 1.6e-06 28.4 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4586) EDR1 PF14381.4 T038320_2 - 6e-37 127.2 0.0 1.1e-36 126.4 0.0 1.3 1 0 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 Arm PF00514.21 T038320_2 - 3.2e-24 84.0 4.1 1.6e-07 31.0 0.0 4.6 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 T038320_2 - 5.3e-12 45.8 6.6 2.2e-06 27.8 1.4 3.9 1 1 3 4 4 4 4 HEAT repeats HEAT_EZ PF13513.4 T038320_2 - 8.8e-12 45.1 3.4 7.1e-05 23.0 0.1 4.3 4 0 0 4 4 4 3 HEAT-like repeat HEAT PF02985.20 T038320_2 - 4.4e-08 32.5 6.5 0.0002 21.2 0.1 4.2 4 0 0 4 4 4 2 HEAT repeat UNC45-central PF11701.6 T038320_2 - 1.4e-07 31.4 2.2 0.00027 20.8 0.2 2.4 2 0 0 2 2 2 2 Myosin-binding striated muscle assembly central Adaptin_N PF01602.18 T038320_2 - 0.00013 20.6 1.0 0.0016 16.9 1.0 2.1 1 1 1 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.5 T038320_2 - 0.00014 21.8 1.0 0.0019 18.1 0.5 2.2 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.6 T038320_2 - 0.0038 17.2 1.0 0.57 10.2 0.1 2.6 2 1 1 3 3 3 1 V-ATPase subunit H HEAT_PBS PF03130.14 T038320_2 - 0.004 17.6 0.5 0.11 13.2 0.5 2.9 2 0 0 2 2 2 1 PBS lyase HEAT-like repeat IFRD PF05004.11 T038320_2 - 0.17 10.8 4.3 5.4 5.9 0.4 3.1 1 1 2 3 3 3 0 Interferon-related developmental regulator (IFRD) Arm PF00514.21 T038320_3 - 6.7e-12 44.9 0.0 2.2e-05 24.2 0.0 2.8 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT PF02985.20 T038320_3 - 6.9e-05 22.6 0.0 0.15 12.2 0.0 2.8 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.4 T038320_3 - 0.00061 20.0 0.0 0.14 12.4 0.0 2.3 1 1 1 2 2 2 2 HEAT repeats Cnd1 PF12717.5 T038320_3 - 0.0024 17.7 0.6 0.19 11.6 0.3 2.2 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 T038320_3 - 0.005 17.1 0.0 0.82 10.1 0.0 2.5 2 0 0 2 2 2 1 HEAT-like repeat Pkinase PF00069.23 T060903_1 - 2.9e-54 184.1 0.0 4.3e-54 183.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T060903_1 - 3.7e-27 95.1 0.0 7.1e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.8 T060903_1 - 2.8e-19 68.9 19.9 2.8e-19 68.9 19.9 6.2 5 1 1 6 6 6 2 DMPK coiled coil domain like Kinase-like PF14531.4 T060903_1 - 4.8e-07 29.2 0.0 1e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 T060903_1 - 0.0012 19.4 0.1 0.0026 18.3 0.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.4 T060903_1 - 0.021 14.3 0.0 6.8 6.1 0.0 2.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 C1_1 PF00130.20 T060903_1 - 0.034 13.9 0.8 0.085 12.6 0.0 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) IncA PF04156.12 T060903_1 - 0.22 11.1 72.5 0.0093 15.6 20.0 4.4 4 0 0 4 4 4 0 IncA protein APG6 PF04111.10 T060903_1 - 2.2 7.4 55.1 0.14 11.4 16.6 3.6 3 1 1 4 4 4 0 Autophagy protein Apg6 CNH PF00780.20 T060903_2 - 2.8e-51 174.6 0.0 3.8e-51 174.2 0.0 1.1 1 0 0 1 1 1 1 CNH domain PH PF00169.27 T060903_2 - 0.00017 21.9 0.0 0.00049 20.4 0.0 1.8 2 0 0 2 2 2 1 PH domain PBD PF00786.26 T060903_2 - 0.0031 17.8 0.1 0.0062 16.8 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain TLV_coat PF00429.17 T353225_1 - 0.0043 15.6 1.4 0.0064 15.1 1.4 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) C2 PF00168.28 T186495_2 - 1.9e-40 137.2 0.3 3e-17 62.7 0.0 6.2 4 2 0 5 5 5 4 C2 domain Ferlin_C PF16165.3 T186495_2 - 1.7e-31 109.1 1.9 1.5e-27 96.3 0.1 3.8 2 2 2 4 4 4 2 Ferlin C-terminus FerB PF08150.10 T186495_3 - 1.3e-22 80.1 0.0 2.6e-22 79.1 0.0 1.5 1 0 0 1 1 1 1 FerB (NUC096) domain tify PF06200.12 T147293_3 - 0.27 10.5 0.0 0.27 10.5 0.0 1.7 2 0 0 2 2 2 0 tify domain LRR_8 PF13855.4 T094180_2 - 3.9e-14 52.0 10.6 1.8e-10 40.3 0.6 3.0 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.5 T094180_2 - 3.6e-07 30.2 17.4 0.00074 19.7 0.1 4.6 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 T094180_2 - 0.00017 21.4 8.2 0.91 10.1 0.0 5.5 4 2 0 4 4 4 2 Leucine Rich Repeat LRR_6 PF13516.4 T094180_2 - 0.11 12.5 5.3 3.8 7.7 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich repeat Methyltransf_11 PF08241.10 T213982_3 - 3.4e-19 69.1 0.0 2e-18 66.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 T213982_3 - 2.1e-14 53.9 0.0 1.1e-13 51.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.4 T213982_3 - 4e-14 52.7 0.0 7e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T213982_3 - 1.4e-10 41.1 0.0 6e-10 39.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.10 T213982_3 - 1.5e-10 41.5 0.0 3.6e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 T213982_3 - 4.9e-07 29.2 0.0 9.2e-07 28.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.10 T213982_3 - 0.015 14.7 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW MTS PF05175.12 T213982_3 - 0.016 14.6 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain MyTH4 PF00784.15 T143214_1 - 6.2e-25 87.6 0.1 1.4e-24 86.5 0.1 1.6 1 0 0 1 1 1 1 MyTH4 domain SH3_2 PF07653.15 T143214_1 - 1.2e-15 56.8 0.0 2.3e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain 2OG-FeII_Oxy_2 PF13532.4 T143214_1 - 1.4e-08 35.1 0.0 2.8e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RRM_1 PF00076.20 T116329_1 - 2.6e-07 30.2 0.0 4.4e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 T116329_1 - 0.17 11.9 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 Limkain b1 RRM_1 PF00076.20 T116329_2 - 3e-33 113.3 0.4 9.1e-17 60.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_38 PF01074.20 T122177_2 - 1.4e-106 356.0 0.3 2e-106 355.5 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.11 T122177_2 - 1.5e-84 284.5 0.0 2.4e-84 283.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.9 T122177_2 - 6e-24 84.1 0.0 1.4e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Neil1-DNA_bind PF09292.8 T119790_1 - 5.7e-17 61.2 0.2 1.2e-16 60.1 0.2 1.6 1 0 0 1 1 1 1 Endonuclease VIII-like 1, DNA bind DUF4764 PF15961.3 T110783_1 - 0 1252.9 1.1 0 1252.7 1.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) K_channel_TID PF07941.9 T110783_1 - 2.6 8.5 6.7 7.5 7.0 5.6 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain DUF4939 PF16297.3 T110339_1 - 1.2e-13 50.7 0.0 2.6e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 T110339_1 - 8.7e-10 38.6 0.1 3.9e-09 36.6 0.0 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein gag-asp_proteas PF13975.4 T110339_1 - 4.7e-05 23.7 0.0 0.0001 22.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.4 T110339_1 - 0.00011 22.7 0.0 0.00026 21.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease RVT_1 PF00078.25 T110339_1 - 0.00034 20.1 0.0 0.00057 19.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.9 T110339_1 - 0.0076 16.1 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease PhoLip_ATPase_C PF16212.3 T116530_1 - 1.5e-86 290.1 29.2 1.5e-86 290.1 29.2 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 T116530_1 - 1.4e-29 101.5 3.4 3.4e-29 100.2 3.4 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.4 T116530_1 - 8.5e-10 38.5 0.0 8.3e-09 35.3 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 T116530_1 - 2.8e-08 34.2 2.2 0.0014 18.8 0.9 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.18 T116530_1 - 2.8e-06 26.7 0.0 6.9e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.10 T116530_1 - 0.0015 18.2 0.0 0.0032 17.1 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Synaptobrevin PF00957.19 T193161_1 - 6e-55 182.9 10.3 4.5e-30 103.2 1.7 2.2 2 0 0 2 2 2 2 Synaptobrevin Ferlin_C PF16165.3 T193161_1 - 0.0078 16.0 0.9 0.094 12.5 0.3 2.2 2 0 0 2 2 2 1 Ferlin C-terminus DUF912 PF06024.10 T193161_1 - 0.0082 16.3 1.5 0.43 10.8 0.2 2.2 2 0 0 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF912) ODV-E18 PF10717.7 T193161_1 - 0.0083 15.9 3.8 1.2 8.9 0.6 2.5 2 0 0 2 2 2 2 Occlusion-derived virus envelope protein ODV-E18 MCU PF04678.11 T193161_1 - 0.077 13.0 1.0 0.81 9.7 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial calcium uniporter DUF2207 PF09972.7 T193161_1 - 0.079 11.6 0.0 4.6 5.8 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Virul_fac_BrkB PF03631.13 T193161_1 - 0.08 12.4 1.9 6.8 6.1 0.5 2.2 2 0 0 2 2 2 0 Virulence factor BrkB Sec20 PF03908.11 T193161_1 - 0.11 12.3 1.7 1.3 8.8 0.1 2.4 2 0 0 2 2 2 0 Sec20 GP41 PF00517.15 T193161_1 - 0.11 12.1 3.1 2.2 7.9 0.1 2.2 2 0 0 2 2 2 0 Retroviral envelope protein EVI2A PF05399.9 T193161_1 - 0.13 11.7 2.3 4 6.8 0.2 2.5 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) Peptidase_M56 PF05569.9 T193161_1 - 0.3 10.1 1.2 2.3 7.2 0.3 2.0 2 0 0 2 2 2 0 BlaR1 peptidase M56 Prominin PF05478.9 T193161_1 - 0.81 7.4 3.4 2.1 6.1 0.3 2.1 2 0 0 2 2 2 0 Prominin Baculo_11_kDa PF06143.9 T193161_1 - 4 7.0 9.8 11 5.5 0.4 2.3 2 0 0 2 2 2 0 Baculovirus 11 kDa family OppC_N PF12911.5 T193161_1 - 6.7 6.7 8.1 4.2 7.3 0.5 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C zf-RING_2 PF13639.4 T193161_3 - 9.8e-13 48.0 8.4 9.8e-13 48.0 8.4 4.6 5 1 1 6 6 4 1 Ring finger domain zf-C3HC4_2 PF13923.4 T193161_3 - 4.1e-09 36.0 8.5 4.1e-09 36.0 8.5 2.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 T193161_3 - 6.8e-09 35.8 4.5 2.6e-08 33.9 4.5 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 T193161_3 - 1.3e-06 28.0 8.1 1.3e-06 28.0 8.1 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 T193161_3 - 1.8e-06 27.4 6.9 1.8e-06 27.4 6.9 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.4 T193161_3 - 1.8e-05 24.5 5.0 1.8e-05 24.5 5.0 2.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 T193161_3 - 2.6e-05 24.0 6.0 2.6e-05 24.0 6.0 3.4 3 0 0 3 3 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 T193161_3 - 0.00022 21.1 0.8 0.00022 21.1 0.8 2.1 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.4 T193161_3 - 0.00029 20.5 3.3 0.00029 20.5 3.3 3.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 T193161_3 - 0.00032 20.3 3.9 0.00032 20.3 3.9 3.4 4 0 0 4 4 3 1 Prokaryotic RING finger family 4 zf-Nse PF11789.6 T193161_3 - 0.0022 17.6 3.8 0.005 16.5 3.8 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Rad50_zn_hook PF04423.12 T193161_3 - 0.016 14.9 1.2 5.8 6.7 0.1 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif Zn_ribbon_17 PF17120.3 T193161_3 - 0.66 9.5 11.2 0.017 14.6 3.8 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Trypsin PF00089.24 T003043_2 - 6.1e-56 189.6 0.0 1e-55 188.8 0.0 1.4 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 T003043_2 - 2.8e-44 149.8 0.0 1.4e-28 99.3 0.1 2.7 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 T003043_2 - 3.7e-20 72.2 14.5 3.4e-10 40.3 0.3 3.4 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) EGF_CA PF07645.13 T003043_2 - 7.9e-07 29.0 5.2 7.9e-07 29.0 5.2 2.4 3 0 0 3 3 3 1 Calcium-binding EGF domain FXa_inhibition PF14670.4 T003043_2 - 3.6e-05 23.8 8.6 3.6e-05 23.8 8.6 2.5 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.5 T003043_2 - 0.0056 16.5 2.8 0.0056 16.5 2.8 2.8 4 0 0 4 4 4 1 Complement Clr-like EGF-like CUB_2 PF02408.18 T003043_2 - 0.051 13.2 0.0 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 CUB-like domain PDZ PF00595.22 T140779_1 - 7.4e-65 215.2 10.1 5.1e-21 74.7 0.1 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) Guanylate_kin PF00625.19 T140779_1 - 2.2e-34 118.6 0.0 3e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ_assoc PF10600.7 T140779_1 - 2e-26 92.5 6.5 2e-26 92.5 6.5 2.5 2 0 0 2 2 2 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 T140779_1 - 3.7e-17 62.3 1.7 2.9e-06 27.4 0.0 3.3 3 0 0 3 3 3 3 PDZ domain MAGUK_N_PEST PF10608.7 T140779_1 - 1.4e-12 48.0 4.9 3.5e-09 37.1 0.8 2.4 1 1 1 2 2 2 2 Polyubiquitination (PEST) N-terminal domain of MAGUK SH3_1 PF00018.26 T140779_1 - 4.5e-08 32.4 0.0 1.1e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 T140779_1 - 2.8e-07 30.0 0.0 6.7e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T140779_1 - 0.0047 16.6 0.9 0.02 14.6 0.1 2.3 2 0 0 2 2 2 1 Variant SH3 domain Guanylate_kin PF00625.19 T140779_2 - 7.9e-08 32.1 0.1 1.1e-07 31.5 0.1 1.2 1 0 0 1 1 1 1 Guanylate kinase L27_1 PF09058.8 T140779_3 - 4.9e-06 26.4 0.1 8.3e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 L27_1 RRM_1 PF00076.20 T019372_1 - 8.6e-18 63.8 0.0 1.3e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 T019372_1 - 1.1e-05 25.3 0.0 3e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 RNA binding motif RRM_5 PF13893.4 T019372_1 - 0.00082 18.8 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U3_assoc_6 PF08640.9 T145294_3 - 7.1e-25 86.8 6.1 7.1e-25 86.8 6.1 2.5 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 6 NRDE-2 PF08424.8 T145294_3 - 1.1e-05 24.6 12.5 0.032 13.2 2.4 3.3 3 0 0 3 3 3 3 NRDE-2, necessary for RNA interference TPR_14 PF13428.4 T145294_3 - 0.0049 17.4 3.2 3.8 8.5 0.1 5.5 7 0 0 7 7 7 1 Tetratricopeptide repeat RabGAP-TBC PF00566.16 T120233_1 - 4.7e-57 193.0 2.0 4.7e-57 193.0 2.0 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain PH PF00169.27 T120233_1 - 2.9e-06 27.6 0.0 5.6e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 PH domain DUF4795 PF16043.3 T120233_1 - 0.011 15.2 7.0 0.018 14.5 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) KRAB PF01352.25 T120233_1 - 0.011 15.2 0.2 0.028 14.0 0.2 1.6 1 0 0 1 1 1 0 KRAB box NBP1 PF08537.8 T120233_1 - 0.02 14.2 0.2 0.044 13.1 0.2 1.4 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 PH_8 PF15409.4 T120233_1 - 0.12 12.5 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Spc29 PF17082.3 T120233_1 - 1.2 8.8 5.6 6.7 6.4 0.3 2.2 2 0 0 2 2 2 0 Spindle Pole Component 29 DUF1664 PF07889.10 T120233_1 - 1.2 9.0 9.4 6.7 6.6 0.5 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) AAA_13 PF13166.4 T120233_1 - 4.9 5.5 7.1 17 3.8 7.1 1.6 1 1 0 1 1 1 0 AAA domain IncA PF04156.12 T120233_1 - 8.6 6.0 21.9 0.51 10.0 9.9 2.4 2 0 0 2 2 2 0 IncA protein SCAN PF02023.15 T140235_3 - 5.3e-41 138.2 3.0 1.1e-40 137.2 3.0 1.6 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 T140235_3 - 8e-34 114.4 33.8 3e-08 33.6 0.4 6.7 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 T140235_3 - 5e-26 89.5 29.4 9.4e-07 28.8 1.0 5.6 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T140235_3 - 2.2e-12 46.5 30.4 0.0049 17.5 0.7 5.9 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T140235_3 - 2.4e-09 36.8 24.3 0.19 11.6 0.7 5.7 5 0 0 5 5 5 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T140235_3 - 0.00014 21.7 19.5 0.017 15.1 3.0 3.8 2 1 1 3 3 3 2 Zinc ribbon domain XPA_N PF01286.16 T140235_3 - 0.0035 17.2 21.8 0.25 11.3 0.4 5.3 5 0 0 5 5 5 2 XPA protein N-terminal zf-trcl PF13451.4 T140235_3 - 0.022 14.5 16.4 11 5.9 0.1 5.3 5 0 0 5 5 5 0 Probable zinc-ribbon domain DZR PF12773.5 T140235_3 - 0.13 12.2 15.1 1.1 9.2 5.1 3.2 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_15 PF17032.3 T140235_3 - 0.21 12.2 14.8 3.3 8.4 1.5 3.2 1 1 2 3 3 3 0 zinc-ribbon family HypA PF01155.17 T140235_3 - 0.25 11.3 11.8 5.3 7.0 3.6 3.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_jaz PF12171.6 T140235_3 - 0.44 10.8 16.8 3.1 8.1 0.1 5.1 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 T140235_3 - 1.3 9.3 11.6 0.63 10.3 1.3 2.8 1 1 1 3 3 3 0 zinc-finger-containing domain zf-C2H2_11 PF16622.3 T140235_3 - 1.5 8.5 18.1 0.21 11.2 0.3 5.2 5 0 0 5 5 5 0 zinc-finger C2H2-type YhfH PF14149.4 T140235_3 - 2 8.3 17.0 28 4.7 0.1 5.3 5 0 0 5 5 5 0 YhfH-like protein ADK_lid PF05191.12 T140235_3 - 2.4 8.1 11.4 5.4 7.0 1.7 3.7 2 1 1 3 3 3 0 Adenylate kinase, active site lid zf-LYAR PF08790.9 T140235_3 - 3.1 7.7 14.9 0.92 9.3 0.3 4.5 5 0 0 5 5 4 0 LYAR-type C2HC zinc finger LIM PF00412.20 T140235_3 - 3.1 8.0 13.2 7.4 6.7 1.2 3.9 1 1 1 3 3 3 0 LIM domain DUF2321 PF10083.7 T140235_3 - 3.6 7.1 12.2 1.5 8.3 1.7 3.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) CpXC PF14353.4 T140235_3 - 7.1 6.6 11.6 9.5 6.2 0.0 4.5 2 1 2 4 4 4 0 CpXC protein RhoGAP PF00620.25 T169710_3 - 1.8e-44 151.1 0.0 2.7e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain 7tm_4 PF13853.4 T100311_3 - 6.8e-14 52.1 6.2 1.1e-13 51.4 6.2 1.4 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T100311_3 - 7.9e-06 25.2 4.2 7.9e-06 25.2 4.2 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) SNF2_N PF00176.21 T376616_2 - 8.4e-64 215.4 0.2 1.7e-63 214.3 0.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 T376616_2 - 4.9e-15 55.7 0.0 1.7e-14 54.0 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Plexin_cytopl PF08337.10 T242093_1 - 3.2e-217 722.5 0.0 4.5e-217 722.0 0.0 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.17 T242093_2 - 1.4e-54 185.4 0.0 1.9e-54 184.9 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 T242093_2 - 1.2e-36 124.4 0.0 7.6e-11 41.8 0.0 5.2 4 1 0 4 4 4 4 IPT/TIG domain PSI PF01437.23 T242093_2 - 4.1e-15 55.9 31.4 6.8e-11 42.4 13.3 3.5 2 0 0 2 2 2 2 Plexin repeat Plexin_cytopl PF08337.10 T242093_3 - 0.071 11.6 0.0 0.094 11.2 0.0 1.0 1 0 0 1 1 1 0 Plexin cytoplasmic RasGAP domain HECT PF00632.23 T209274_3 - 2.6e-87 293.0 0.4 7e-87 291.6 0.0 1.9 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) WWE PF02825.18 T209274_3 - 4.9e-19 68.5 0.1 9.7e-19 67.6 0.1 1.5 1 0 0 1 1 1 1 WWE domain UNC45-central PF11701.6 T209274_3 - 0.015 15.1 0.9 0.047 13.5 0.0 2.2 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central Integrase_AP2 PF14657.4 T269427_1 - 2.8 7.6 5.9 5.5 6.7 5.9 1.4 1 0 0 1 1 1 0 AP2-like DNA-binding integrase domain Collagen PF01391.16 T269427_3 - 7.1e-65 214.5 306.5 3.1e-09 36.3 29.8 9.8 4 2 6 10 10 10 9 Collagen triple helix repeat (20 copies) AAA PF00004.27 T323856_1 - 4.7e-37 127.2 0.0 7.9e-37 126.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 T323856_1 - 1.2e-06 28.3 0.0 2.5e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.10 T323856_1 - 0.00099 18.3 0.0 0.0016 17.6 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.12 T323856_1 - 0.0093 16.0 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.12 T323856_1 - 0.0094 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 T323856_1 - 0.03 14.6 0.8 0.19 12.0 0.8 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 T323856_1 - 0.11 12.6 0.6 0.7 10.0 0.6 2.0 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.11 T323856_1 - 0.16 10.7 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 TIP49 C-terminus ILEI PF15711.3 T382603_1 - 4.7e-25 87.7 0.0 7.1e-25 87.2 0.0 1.3 1 0 0 1 1 1 1 Interleukin-like EMT inducer CCDC84 PF14968.4 T382603_1 - 0.045 13.2 0.4 0.067 12.7 0.4 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 Vasohibin PF14822.4 T030197_1 - 3.6e-121 402.9 0.2 4.7e-121 402.5 0.2 1.1 1 0 0 1 1 1 1 Vasohibin TPR_2 PF07719.15 T183426_1 - 9e-12 44.0 0.1 0.024 14.6 0.0 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_12 PF13424.4 T183426_1 - 2.4e-09 37.2 1.3 0.0013 18.9 0.0 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 T183426_1 - 2.8e-08 33.1 0.0 0.0058 16.3 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.4 T183426_1 - 3.6e-08 33.7 0.1 1.9e-05 24.9 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.4 T183426_1 - 2.3e-07 31.2 0.0 0.0057 17.2 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.4 T183426_1 - 0.0005 20.4 0.2 0.0072 16.8 0.0 3.1 4 0 0 4 4 3 1 Tetratricopeptide repeat Coatomer_E PF04733.12 T183426_1 - 0.0016 17.8 0.1 0.0025 17.2 0.1 1.2 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_8 PF13181.4 T183426_1 - 0.0091 16.0 0.0 28 5.1 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.4 T183426_1 - 0.017 15.8 0.0 34 5.5 0.0 3.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.4 T183426_1 - 0.031 14.5 0.2 0.41 11.0 0.1 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_9 PF13371.4 T183426_1 - 0.076 13.1 0.1 0.51 10.4 0.1 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.8 T183426_1 - 0.092 12.3 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) ANAPC3 PF12895.5 T183426_1 - 0.16 12.1 0.2 9.2 6.4 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Pericardin_rpt PF07054.9 T183426_1 - 0.39 10.7 19.7 1.3 9.1 0.5 3.6 2 1 0 2 2 2 0 Pericardin like repeat DNA_pol_A_exo1 PF01612.18 T114972_3 - 1e-09 38.3 0.1 1.7e-09 37.5 0.1 1.3 1 0 0 1 1 1 1 3'-5' exonuclease tRNA-synt_1c PF00749.19 T242386_1 - 1.2e-116 388.9 0.0 1.5e-116 388.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.13 T242386_1 - 1.4e-49 168.0 0.0 2.4e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.16 T242386_1 - 8.4e-42 142.9 0.0 1.2e-41 142.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.13 T242386_1 - 7.3e-27 94.0 1.6 7.3e-27 94.0 1.6 1.6 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 IMPDH PF00478.23 T242386_3 - 3.3e-139 463.6 2.2 4.6e-139 463.1 2.2 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain DUF3504 PF12012.6 T242386_3 - 3.5e-61 205.7 0.7 7.4e-61 204.6 0.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) NMO PF03060.13 T242386_3 - 4.2e-12 46.0 0.5 4.5e-07 29.4 0.4 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase CBS PF00571.26 T242386_3 - 1.6e-11 44.3 0.6 1.2e-05 25.5 0.1 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.16 T242386_3 - 3.4e-09 36.1 0.6 5.9e-09 35.3 0.6 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.19 T242386_3 - 0.00029 20.2 1.1 0.0042 16.4 0.1 2.1 1 1 1 2 2 2 1 Histidine biosynthesis protein NanE PF04131.12 T242386_3 - 0.00048 19.2 0.2 0.00085 18.4 0.2 1.2 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.12 T242386_3 - 0.0072 15.5 1.0 0.015 14.5 1.0 1.5 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG CARD PF00619.19 T242386_3 - 0.025 14.5 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 Caspase recruitment domain DUF4683 PF15735.3 T309660_2 - 1.5e-164 548.3 13.4 1.5e-164 548.3 13.4 4.5 5 0 0 5 5 5 1 Domain of unknown function (DUF4683) DNA_pol_B PF00136.19 T309660_2 - 5.9e-102 341.6 0.0 8.9e-102 341.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.17 T309660_2 - 5.5e-28 97.9 0.1 1.1e-14 54.2 0.1 2.4 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain DUF1725 PF08333.9 T309660_2 - 2.8e-08 33.1 0.8 5.9e-08 32.0 0.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) zf-C4pol PF14260.4 T309660_3 - 3.2e-12 46.6 9.5 1.4e-11 44.5 9.5 2.2 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta zf-C2HC_2 PF13913.4 T107482_3 - 0.02 14.7 5.5 0.045 13.5 5.5 1.6 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Fungus-induced PF10917.6 T330148_1 - 0.37 11.0 3.1 3.3 8.0 0.8 2.6 2 0 0 2 2 2 0 Fungus-induced protein EF-hand_8 PF13833.4 T330148_2 - 0.0071 16.0 0.1 3.9 7.2 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.30 T330148_2 - 0.11 12.0 0.0 2.9 7.5 0.0 2.5 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.4 T330148_2 - 0.14 12.1 0.4 0.29 11.0 0.1 1.7 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.4 T330148_2 - 0.16 12.3 0.1 0.35 11.3 0.1 1.6 1 1 0 1 1 1 0 EF-hand domain pair LIM PF00412.20 T120027_2 - 1.8e-28 98.4 17.4 2.8e-15 56.1 1.5 2.5 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 T120027_2 - 1.3e-14 53.7 0.2 2.3e-14 52.8 0.2 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 T120027_2 - 0.00012 21.8 0.0 0.00027 20.6 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain DAGK_acc PF00609.17 T259165_1 - 7.3e-49 166.0 0.0 9.7e-49 165.6 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 T259165_1 - 6.2e-23 80.6 0.0 1.1e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain RA PF00788.21 T259165_2 - 6.5e-22 77.8 0.1 3.9e-15 56.1 0.1 3.0 3 0 0 3 3 3 2 Ras association (RalGDS/AF-6) domain C1_1 PF00130.20 T259165_2 - 2.1e-21 75.4 43.3 4e-10 39.3 4.4 3.9 3 0 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.14 T259165_2 - 0.003 17.7 24.6 0.14 12.4 2.0 4.0 3 0 0 3 3 3 2 C1 domain Kringle PF00051.16 T058025_2 - 1.5e-48 162.9 11.3 3.1e-25 88.2 3.0 2.4 2 0 0 2 2 2 2 Kringle domain Thrombin_light PF09396.8 T058025_2 - 8.9e-27 92.5 1.0 1.5e-26 91.7 1.0 1.4 1 0 0 1 1 1 1 Thrombin light chain Gla PF00594.18 T058025_2 - 4.9e-18 64.9 5.1 9.4e-18 64.0 5.1 1.5 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Trypsin PF00089.24 T058025_3 - 1.7e-62 211.0 0.0 2.4e-62 210.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 T058025_3 - 0.013 15.8 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 T058025_3 - 0.068 13.9 0.0 0.13 13.0 0.0 1.5 1 0 0 1 1 1 0 Trypsin-like peptidase domain HLH PF00010.24 T147800_1 - 3.4e-15 55.6 0.1 5.8e-15 54.9 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CoaE PF01121.18 T147800_3 - 7.2e-39 133.2 0.0 1.1e-38 132.5 0.0 1.3 1 0 0 1 1 1 1 Dephospho-CoA kinase CTP_transf_like PF01467.24 T147800_3 - 8.3e-08 32.4 0.0 1.3e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like AAA_33 PF13671.4 T147800_3 - 0.00065 19.7 0.0 0.0013 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 T147800_3 - 0.011 16.1 0.0 0.021 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain PRK PF00485.16 T147800_3 - 0.28 10.7 0.5 0.44 10.1 0.5 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AKAP2_C PF15304.4 T364579_1 - 6.5e-14 51.8 5.5 6.5e-14 51.8 5.5 2.8 2 1 0 2 2 2 1 A-kinase anchor protein 2 C-terminus Pkinase PF00069.23 T311731_3 - 2.8e-69 233.3 0.0 3.7e-69 232.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T311731_3 - 5.3e-35 120.8 0.0 7.9e-35 120.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T311731_3 - 1.8e-06 27.4 0.0 3.1e-06 26.6 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 T311731_3 - 1.4e-05 25.5 0.1 3.3e-05 24.4 0.1 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.12 T311731_3 - 0.025 13.8 0.0 0.042 13.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 T311731_3 - 0.14 11.6 0.1 5.7 6.4 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 FOXP-CC PF16159.3 T245052_2 - 3.3e-33 114.0 5.3 3.3e-33 114.0 5.3 2.4 2 0 0 2 2 2 1 FOXP coiled-coil domain Forkhead PF00250.16 T245052_2 - 6.3e-27 93.6 0.2 1.2e-26 92.7 0.2 1.5 1 0 0 1 1 1 1 Forkhead domain RWD PF05773.20 T310251_1 - 7.4e-21 74.5 1.0 1.5e-20 73.5 1.0 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.3 T310251_1 - 2.5e-05 24.5 6.0 2.5e-05 24.5 6.0 2.3 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 BUD22 PF09073.8 T310251_1 - 3.3 6.8 11.8 5.2 6.2 11.8 1.2 1 0 0 1 1 1 0 BUD22 Radial_spoke PF04712.10 T310251_2 - 8.5e-38 130.4 0.1 1.3e-37 129.8 0.1 1.2 1 0 0 1 1 1 1 Radial spokehead-like protein Radial_spoke PF04712.10 T310251_3 - 2.5e-150 501.6 9.6 3.6e-150 501.0 9.6 1.2 1 0 0 1 1 1 1 Radial spokehead-like protein HGTP_anticodon PF03129.18 T123788_2 - 1.2e-11 44.4 0.1 1.9e-11 43.8 0.1 1.2 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.23 T123788_3 - 1.5e-35 122.6 0.0 2.2e-35 122.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) TGS PF02824.19 T123788_3 - 2.2e-11 43.5 0.0 4e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.12 T123788_3 - 1.1e-10 41.3 0.1 2.2e-10 40.3 0.1 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain RTP1_C1 PF10363.7 T217283_1 - 0.002 18.1 0.0 0.005 16.9 0.0 1.6 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF3452 PF11934.6 T217283_2 - 5.1e-26 90.7 0.1 9.5e-26 89.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3452) RB_A PF01858.15 T217283_3 - 2.4e-78 262.4 1.9 6.6e-78 261.0 0.5 2.1 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain RB_B PF01857.18 T217283_3 - 3.8e-53 178.9 0.7 8e-53 177.9 0.7 1.6 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Rb_C PF08934.8 T217283_3 - 3.6e-06 26.7 0.6 7.2e-06 25.8 0.6 1.4 1 0 0 1 1 1 1 Rb C-terminal domain DUF3452 PF11934.6 T217283_3 - 0.00028 20.3 0.1 0.00061 19.2 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3452) ATLF PF07737.9 T217283_3 - 0.057 12.6 0.1 0.094 11.9 0.1 1.2 1 0 0 1 1 1 0 Anthrax toxin lethal factor, N- and C-terminal domain Rib_5-P_isom_A PF06026.12 T193612_3 - 2.2e-64 216.1 0.0 3e-64 215.7 0.0 1.2 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Sugar-bind PF04198.11 T193612_3 - 0.015 14.3 0.0 0.023 13.7 0.0 1.1 1 0 0 1 1 1 0 Putative sugar-binding domain DeoRC PF00455.20 T193612_3 - 0.11 12.3 0.1 0.22 11.3 0.1 1.5 1 1 0 1 1 1 0 DeoR C terminal sensor domain Oscp1 PF10188.7 T008060_2 - 1.7e-77 259.4 3.0 2.5e-77 258.8 3.0 1.3 1 0 0 1 1 1 1 Organic solute transport protein 1 Ribosomal_S15 PF00312.20 T008060_2 - 6e-20 71.1 2.2 1.2e-19 70.1 2.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S15 Lep_receptor_Ig PF06328.9 T008060_3 - 1.7e-31 107.9 0.2 3.7e-31 106.9 0.2 1.6 1 0 0 1 1 1 1 Ig-like C2-type domain fn3 PF00041.19 T008060_3 - 1.5e-18 66.7 0.4 1.3e-06 28.5 0.0 5.3 5 0 0 5 5 5 3 Fibronectin type III domain EpoR_lig-bind PF09067.8 T008060_3 - 0.0054 16.8 0.0 0.0099 15.9 0.0 1.4 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3_2 PF16893.3 T008060_3 - 0.058 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Fibronectin type III domain zf-C6H2 PF15801.3 T162232_2 - 0.002 18.2 3.9 0.011 15.9 3.9 2.3 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding Neur_chan_memb PF02932.14 T209740_3 - 6.4e-73 245.6 0.2 9.1e-73 245.1 0.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 T209740_3 - 5.4e-69 231.8 0.2 7.4e-69 231.3 0.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Trypsin PF00089.24 T209740_3 - 1.6e-65 220.8 0.0 2.3e-65 220.4 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 T209740_3 - 3.4e-05 24.6 0.0 7.4e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 T209740_3 - 0.00015 22.0 0.0 0.00027 21.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) IQ_SEC7_PH PF16453.3 T375014_1 - 1.4e-63 212.8 0.3 3e-63 211.8 0.3 1.6 1 0 0 1 1 1 1 PH domain Sec7 PF01369.18 T375014_1 - 2.1e-55 187.2 0.0 3.1e-55 186.6 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain Pkinase_Tyr PF07714.15 T022728_1 - 2e-92 309.0 0.0 2.7e-92 308.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T022728_1 - 3.9e-42 144.3 0.0 5.6e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 T022728_1 - 6.7e-06 26.0 0.0 0.00036 20.4 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T022728_1 - 0.037 14.5 0.0 0.15 12.6 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin domain TPKR_C2 PF16920.3 T022728_3 - 1.5e-13 50.5 2.1 3.6e-13 49.3 2.1 1.7 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain LRR_8 PF13855.4 T022728_3 - 7.6e-11 41.5 3.9 9e-11 41.2 0.5 2.2 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 T022728_3 - 0.51 10.7 7.6 0.23 11.8 0.8 2.7 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) Zona_pellucida PF00100.21 T327070_1 - 5.4e-08 32.8 0.1 8.4e-08 32.2 0.1 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain POM121 PF15229.4 T327070_1 - 0.0018 17.9 0.1 0.0039 16.8 0.1 1.6 1 0 0 1 1 1 1 POM121 family ASC PF00858.22 T335917_1 - 9.4e-45 153.2 0.0 1.3e-44 152.7 0.0 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel ABC_membrane PF00664.21 T335917_2 - 7.1e-52 176.6 3.8 9.3e-52 176.2 3.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 T335917_2 - 5.2e-31 107.8 0.0 7.8e-31 107.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 T335917_2 - 0.00011 21.6 0.0 0.00038 19.8 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.10 T335917_2 - 0.00025 20.3 0.0 0.00044 19.5 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.4 T335917_2 - 0.0005 20.4 0.0 0.00098 19.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 T335917_2 - 0.01 15.9 0.2 0.07 13.3 0.2 2.1 1 1 0 1 1 1 0 AAA domain ABC_membrane_2 PF06472.13 T335917_2 - 0.034 13.4 2.1 0.051 12.8 2.1 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 AAA_30 PF13604.4 T335917_2 - 0.07 12.7 0.5 0.19 11.3 0.5 1.6 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.15 T335917_2 - 0.11 12.4 0.1 0.19 11.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF87 APS_kinase PF01583.18 T335917_2 - 0.13 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase ASC PF00858.22 T335917_3 - 9.4e-40 136.7 0.0 1.4e-39 136.2 0.0 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel SelP_N PF04592.12 T134409_1 - 1.5 8.1 6.4 2.7 7.2 6.4 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Sec6 PF06046.11 T134409_3 - 2.1e-43 148.4 0.0 2.9e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 DUF1704 PF08014.9 T134409_3 - 4.2e-15 55.5 0.5 2e-14 53.3 0.0 1.9 1 1 0 2 2 2 1 Domain of unknown function (DUF1704) SAM_1 PF00536.28 T075796_2 - 1.5e-37 127.7 10.4 6e-17 61.7 0.2 3.8 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T075796_2 - 4.4e-32 109.8 5.8 1e-13 51.0 0.0 3.8 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) DUF16 PF01519.14 T075796_2 - 0.0013 19.1 1.4 0.0013 19.1 1.4 3.4 2 1 1 3 3 3 1 Protein of unknown function DUF16 SAM_PNT PF02198.14 T075796_2 - 0.049 13.5 2.2 4.1 7.3 0.1 3.0 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain DUF4407 PF14362.4 T075796_2 - 0.68 9.1 17.8 7.6 5.7 16.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) RimK PF08443.9 T073272_3 - 2e-41 141.5 0.0 2.8e-41 141.0 0.0 1.2 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.14 T073272_3 - 1.3e-10 40.8 0.0 2.1e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.12 T073272_3 - 3.9e-06 26.9 0.0 5.6e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.4 T073272_3 - 8e-05 21.9 2.0 0.15 11.1 0.3 3.1 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_Ter PF15632.4 T073272_3 - 0.0066 15.1 0.0 0.01 14.5 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon RRM_1 PF00076.20 T267251_3 - 2.6e-34 116.7 0.4 2.8e-16 59.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T267251_3 - 1.3e-16 60.4 0.8 9.3e-08 32.0 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif CBFNT PF08143.9 T267251_3 - 3.3e-12 47.5 27.6 3.3e-12 47.5 27.6 2.6 3 0 0 3 3 3 1 CBFNT (NUC161) domain RRM_3 PF08777.9 T267251_3 - 0.00038 20.3 0.6 0.27 11.2 0.1 2.5 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.4 T267251_3 - 0.004 17.0 0.0 0.5 10.3 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif NID PF07292.11 T267251_3 - 0.039 14.5 0.3 0.21 12.1 0.0 2.2 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) Sec2p PF06428.9 T082007_1 - 6.9e-08 32.2 8.3 1.5e-07 31.1 8.3 1.5 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p NDT80_PhoG PF05224.10 T082007_1 - 4.5e-07 30.1 0.1 7e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family APG6 PF04111.10 T082007_1 - 0.17 11.1 5.1 0.26 10.5 5.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF3584 PF12128.6 T082007_1 - 3.3 5.0 8.1 4.6 4.5 8.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.9 T082007_1 - 5.3 5.7 9.3 8.1 5.1 9.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein MRF_C1 PF13887.4 T082007_2 - 1.1e-20 72.3 0.7 1.9e-20 71.6 0.7 1.4 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 NDT80_PhoG PF05224.10 T082007_2 - 8.6e-16 58.6 0.0 1.4e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Peptidase_S74 PF13884.4 T082007_2 - 3.1e-14 52.9 0.1 6.3e-14 51.9 0.1 1.6 1 0 0 1 1 1 1 Chaperone of endosialidase MRF_C2 PF13888.4 T082007_3 - 1.8e-49 167.0 1.3 3.1e-49 166.2 1.3 1.4 1 0 0 1 1 1 1 Myelin gene regulatory factor C-terminal domain 2 C1q PF00386.19 T045550_3 - 9.9e-24 83.8 0.1 1.6e-23 83.1 0.1 1.4 1 0 0 1 1 1 1 C1q domain EMI PF07546.11 T045550_3 - 1.3e-14 54.5 4.1 3e-14 53.4 4.1 1.7 1 0 0 1 1 1 1 EMI domain DUF1664 PF07889.10 T045550_3 - 0.0011 18.8 16.8 0.69 9.8 0.2 4.8 5 0 0 5 5 5 2 Protein of unknown function (DUF1664) BLOC1_2 PF10046.7 T045550_3 - 0.017 15.3 9.6 0.021 15.0 1.1 3.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Reo_sigmaC PF04582.10 T045550_3 - 0.047 12.9 10.9 1.2 8.4 1.3 4.3 3 1 1 4 4 4 0 Reovirus sigma C capsid protein DUF1154 PF06631.9 T045550_3 - 0.33 10.8 4.4 0.69 9.8 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1154) GAS PF13851.4 T045550_3 - 0.43 9.8 27.4 0.11 11.8 1.1 3.9 2 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding AAA_13 PF13166.4 T045550_3 - 0.91 8.0 15.7 0.12 10.9 10.0 1.9 1 1 1 2 2 2 0 AAA domain Lge1 PF11488.6 T045550_3 - 1.4 9.4 4.3 4.1 7.9 4.3 1.8 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 DUF948 PF06103.9 T045550_3 - 1.6 8.9 8.4 30 4.8 0.5 4.1 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.4 T045550_3 - 7 5.8 23.8 1.3 8.2 7.1 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4407) DUF5082 PF16888.3 T045550_3 - 8.2 6.7 9.3 6.5 7.0 0.8 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) APG6 PF04111.10 T045550_3 - 8.4 5.5 26.6 1.2 8.3 8.6 3.2 3 0 0 3 3 3 0 Autophagy protein Apg6 Ig_2 PF13895.4 T168225_1 - 1.1e-40 137.7 0.5 3.8e-07 30.2 0.0 8.6 8 1 0 8 8 8 6 Immunoglobulin domain Ig_3 PF13927.4 T168225_1 - 1e-31 109.2 17.8 3.8e-09 36.9 0.0 9.6 8 5 0 8 8 8 5 Immunoglobulin domain I-set PF07679.14 T168225_1 - 5.8e-29 99.9 9.0 8e-06 25.7 0.0 10.1 10 1 1 11 11 11 7 Immunoglobulin I-set domain ig PF00047.23 T168225_1 - 3.8e-23 81.3 1.1 0.00013 22.0 0.0 9.9 9 1 0 9 9 9 4 Immunoglobulin domain ICAM_N PF03921.12 T168225_1 - 8e-17 60.6 0.0 8.1e-15 54.2 0.0 2.6 2 0 0 2 2 2 1 Intercellular adhesion molecule (ICAM), N-terminal domain V-set PF07686.15 T168225_1 - 1.4e-06 28.3 8.0 1.3 9.1 0.1 8.3 10 1 1 11 11 11 1 Immunoglobulin V-set domain Izumo-Ig PF16706.3 T168225_1 - 0.00082 19.2 0.1 4.6 7.2 0.0 3.9 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 T168225_1 - 0.0073 16.2 12.1 0.12 12.4 0.0 6.4 8 0 0 8 8 8 1 CD80-like C2-set immunoglobulin domain NPCBM_assoc PF10633.7 T168225_1 - 0.067 13.3 3.7 20 5.4 0.1 4.9 4 1 0 4 4 4 0 NPCBM-associated, NEW3 domain of alpha-galactosidase RNase_Zc3h12a PF11977.6 T008182_1 - 5.8e-36 123.5 0.0 7.9e-36 123.0 0.0 1.1 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain zf-CCCH_2 PF14608.4 T008182_1 - 2.8 8.4 7.9 8.5 6.9 7.9 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger RNase_Zc3h12a PF11977.6 T008182_3 - 5.8e-21 74.8 0.0 2.3e-20 72.8 0.0 1.8 2 0 0 2 2 2 1 Zc3h12a-like Ribonuclease NYN domain Pribosyl_synth PF14572.4 T154819_3 - 3.4e-98 327.0 1.0 6e-98 326.2 1.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain DUF4795 PF16043.3 T154819_3 - 8.2e-66 221.3 4.9 8.2e-66 221.3 4.9 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4795) Pribosyltran_N PF13793.4 T154819_3 - 2.4e-37 127.3 0.2 4.8e-37 126.3 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.25 T154819_3 - 4.2e-05 23.0 0.1 7.8e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MbeD_MobD PF04899.10 T154819_3 - 5.5 7.1 7.8 0.22 11.5 0.1 2.7 3 0 0 3 3 3 0 MbeD/MobD like DHR-2 PF06920.11 T098059_3 - 2.3e-202 673.2 7.9 2.3e-202 673.2 7.9 2.1 2 1 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.4 T098059_3 - 3.3e-53 180.2 0.1 7.3e-53 179.1 0.1 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 T098059_3 - 7.7e-33 112.6 0.2 2e-32 111.3 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.27 T098059_3 - 5.2e-13 49.3 0.2 1.4e-12 47.9 0.2 1.8 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 T098059_3 - 0.00042 20.6 0.0 0.0015 18.8 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain Tektin PF03148.12 T142173_1 - 2.2e-42 145.0 6.4 2.7e-42 144.8 6.4 1.1 1 0 0 1 1 1 1 Tektin family MiaE_2 PF13794.4 T142173_1 - 0.044 13.3 0.0 0.071 12.7 0.0 1.2 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like Tektin PF03148.12 T142173_3 - 1.1e-95 320.5 14.6 1.4e-95 320.1 14.6 1.1 1 0 0 1 1 1 1 Tektin family Atg14 PF10186.7 T142173_3 - 0.088 11.7 5.2 0.14 11.1 5.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CorA PF01544.16 T142173_3 - 0.64 9.2 6.4 1 8.5 6.4 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Fib_alpha PF08702.8 T142173_3 - 0.65 10.0 5.5 1.2 9.1 5.5 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.10 T142173_3 - 1 9.2 6.9 1.5 8.7 6.1 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF745 PF05335.11 T142173_3 - 1.8 8.1 8.6 1.6 8.3 2.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF1664 PF07889.10 T142173_3 - 4.2 7.2 7.8 4 7.3 2.1 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.10 T142173_3 - 8 6.9 6.6 1.9 8.8 1.2 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ANP PF00212.16 T003243_2 - 1.1e-13 51.0 4.9 1.1e-13 51.0 4.9 2.0 2 0 0 2 2 2 1 Atrial natriuretic peptide IMUP PF15761.3 T003243_2 - 0.31 11.6 3.9 0.72 10.4 3.9 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein LIM PF00412.20 T382001_1 - 0.0039 17.2 14.7 0.012 15.7 14.7 1.9 1 0 0 1 1 1 1 LIM domain SCAN PF02023.15 T182545_1 - 8e-39 131.2 0.1 1.4e-38 130.5 0.1 1.3 1 0 0 1 1 1 1 SCAN domain KRAB PF01352.25 T182545_1 - 6e-35 118.5 3.6 4.2e-21 74.2 0.2 2.5 2 0 0 2 2 2 2 KRAB box zf-C2H2 PF00096.24 T182545_1 - 0.00023 21.3 20.1 0.045 14.1 1.1 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T182545_1 - 0.0021 18.3 14.2 0.0076 16.5 0.4 4.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 T182545_1 - 0.073 13.8 17.4 2.3 9.1 1.8 4.4 3 0 0 3 3 3 0 C2H2-type zinc finger CpXC PF14353.4 T182545_1 - 0.34 10.8 1.7 60 3.6 0.2 3.1 2 1 1 3 3 3 0 CpXC protein Zn-ribbon_8 PF09723.8 T182545_1 - 0.69 10.0 5.6 25 5.0 2.2 3.2 2 0 0 2 2 2 0 Zinc ribbon domain zf-H2C2_2 PF13465.4 T182545_3 - 3.2e-56 185.3 63.1 7.2e-08 32.4 0.2 11.5 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2 PF00096.24 T182545_3 - 2.5e-37 125.1 69.4 8.6e-06 25.8 0.8 10.3 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T182545_3 - 1.3e-19 69.0 66.2 0.015 16.0 1.1 10.9 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T182545_3 - 6.8e-05 22.6 56.4 0.22 11.4 2.3 10.5 10 0 0 10 10 10 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T182545_3 - 8.1e-05 22.7 25.0 0.081 13.1 0.4 7.9 9 0 0 9 9 9 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T182545_3 - 0.00038 20.4 39.4 0.0099 15.8 2.3 6.2 6 1 0 6 6 6 4 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T182545_3 - 0.29 11.8 20.8 3.1 8.5 0.8 4.9 1 1 3 5 5 5 0 zinc-ribbon family GAGA PF09237.9 T182545_3 - 0.72 9.6 9.2 1.8 8.3 0.8 3.7 3 1 1 4 4 4 0 GAGA factor HypA PF01155.17 T182545_3 - 1.1 9.2 20.2 5.1 7.0 1.7 4.6 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FdhE PF04216.10 T182545_3 - 1.7 8.3 10.2 3.5 7.2 2.8 2.3 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation Ig_2 PF13895.4 T181041_2 - 2.9e-09 37.0 0.0 0.00061 19.9 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 T181041_2 - 6.7e-07 29.7 0.0 0.0011 19.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 T181041_2 - 0.0029 17.6 0.0 0.015 15.3 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain TPR_2 PF07719.15 T119182_3 - 3.2e-33 111.0 19.7 0.00016 21.4 0.0 9.8 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.26 T119182_3 - 1e-29 101.0 25.0 0.0001 21.9 0.0 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.4 T119182_3 - 8e-24 81.7 21.1 1.8e-05 24.4 0.0 9.1 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_11 PF13414.4 T119182_3 - 1.2e-22 79.2 8.9 2e-08 33.6 0.0 6.9 5 3 1 6 6 6 5 TPR repeat TPR_19 PF14559.4 T119182_3 - 1.3e-18 67.2 8.3 1.3e-05 25.5 0.1 5.1 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.4 T119182_3 - 2.5e-14 53.2 17.4 1.1e-05 25.5 0.2 6.0 5 1 2 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.4 T119182_3 - 5.5e-13 49.2 0.2 0.14 12.8 0.3 5.3 3 2 4 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.4 T119182_3 - 1.8e-12 46.8 0.9 0.0034 17.9 0.0 5.9 3 3 4 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.4 T119182_3 - 1.3e-11 44.3 0.0 0.00019 21.4 0.0 4.3 3 1 1 5 5 4 2 Tetratricopeptide repeat ANAPC3 PF12895.5 T119182_3 - 6.7e-11 42.1 25.9 0.00017 21.6 1.2 5.6 2 2 4 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 T119182_3 - 3e-10 39.6 16.4 0.019 15.2 0.0 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.4 T119182_3 - 1.8e-05 24.3 13.5 0.0068 16.2 0.0 7.0 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_6 PF13174.4 T119182_3 - 3.1e-05 24.2 12.1 10 6.8 0.0 8.7 9 0 0 9 9 9 0 Tetratricopeptide repeat PknG_TPR PF16918.3 T119182_3 - 5.6e-05 21.9 0.3 0.15 10.7 0.1 2.4 2 0 0 2 2 2 2 Protein kinase G tetratricopeptide repeat Wzy_C_2 PF11846.6 T119182_3 - 0.00016 21.5 2.6 0.6 9.9 0.0 3.8 2 2 1 4 4 4 1 Virulence factor membrane-bound polymerase, C-terminal TPR_15 PF13429.4 T119182_3 - 0.00049 19.3 6.3 0.026 13.6 0.1 3.4 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.4 T119182_3 - 0.095 12.9 4.1 2.5 8.3 0.0 3.8 5 0 0 5 5 4 0 Tetratricopeptide repeat BTAD PF03704.15 T119182_3 - 2 8.7 4.8 27 5.0 0.9 3.2 3 1 1 4 4 4 0 Bacterial transcriptional activator domain KASH_CCD PF14662.4 T003700_1 - 0.0016 18.2 35.4 0.0075 16.0 20.2 2.3 2 0 0 2 2 2 2 Coiled-coil region of CCDC155 or KASH Atg14 PF10186.7 T003700_1 - 0.003 16.6 22.2 0.012 14.6 12.9 2.1 2 0 0 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 IncA PF04156.12 T003700_1 - 0.0044 16.7 39.9 0.006 16.3 27.8 3.0 2 1 0 2 2 2 1 IncA protein Spc7 PF08317.9 T003700_1 - 0.034 12.9 33.8 0.012 14.4 21.2 2.2 1 1 0 2 2 2 0 Spc7 kinetochore protein Shugoshin_N PF07558.9 T003700_1 - 0.14 11.9 11.4 1.6 8.5 0.5 3.6 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region TMF_DNA_bd PF12329.6 T003700_1 - 0.25 11.2 37.7 2 8.3 13.6 4.6 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding Cast PF10174.7 T003700_1 - 0.28 9.2 34.8 0.38 8.8 34.8 1.0 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Fez1 PF06818.13 T003700_1 - 0.67 10.2 33.5 0.38 11.1 29.6 2.2 1 1 1 2 2 2 0 Fez1 DUF641 PF04859.10 T003700_1 - 7.3 6.8 27.5 0.14 12.3 4.1 3.3 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) SHE3 PF17078.3 T003700_1 - 7.6 6.0 29.7 6.1 6.4 18.0 2.2 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 KRAB PF01352.25 T171891_1 - 3.7e-12 45.6 1.0 2.3e-11 43.0 1.0 2.2 1 1 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 T171891_3 - 6.6e-228 727.9 353.0 1.1e-08 35.0 3.0 42.7 42 0 0 42 42 42 39 Zinc-finger double domain zf-C2H2 PF00096.24 T171891_3 - 3.6e-148 474.2 288.4 1.4e-05 25.2 1.3 40.3 40 0 0 40 40 40 34 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T171891_3 - 3e-58 189.3 279.8 0.014 16.1 0.5 39.5 39 0 0 39 39 39 32 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T171891_3 - 1.1e-31 108.3 178.2 0.071 13.3 0.3 36.9 37 0 0 37 37 37 18 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T171891_3 - 2.1e-28 97.6 250.7 0.0015 18.3 0.3 36.8 37 0 0 37 37 37 27 C2H2-type zinc finger KRAB PF01352.25 T171891_3 - 5.7e-23 80.2 0.1 1.1e-22 79.3 0.1 1.5 1 0 0 1 1 1 1 KRAB box XPA_N PF01286.16 T171891_3 - 5.8e-15 54.9 201.9 3.3 7.7 0.2 36.8 39 0 0 39 39 39 22 XPA protein N-terminal Zn-ribbon_8 PF09723.8 T171891_3 - 2.3e-12 46.7 225.9 0.19 11.7 3.8 24.7 5 4 28 34 34 34 26 Zinc ribbon domain zf-C2H2_11 PF16622.3 T171891_3 - 7.2e-09 35.1 168.7 0.35 10.5 0.2 32.9 37 0 0 37 37 37 14 zinc-finger C2H2-type DUF1725 PF08333.9 T140580_2 - 2.3e-05 23.7 0.9 5.4e-05 22.6 0.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T140580_2 - 3.4e-05 23.4 0.1 6.2e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) F-box-like PF12937.5 T140580_3 - 5e-07 29.4 3.3 1.4e-06 28.0 3.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T140580_3 - 0.006 16.3 1.8 0.019 14.7 1.8 1.9 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.4 T140580_3 - 4.7 7.4 5.0 2 8.5 1.2 2.5 2 0 0 2 2 2 0 Leucine Rich repeat PRY PF13765.4 T273999_2 - 4.5e-18 64.5 0.0 1.1e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_4 PF15227.4 T273999_2 - 1.1e-17 63.8 9.3 1.1e-17 63.8 9.3 3.6 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 T273999_2 - 1.3e-11 44.2 7.3 1.3e-11 44.2 7.3 3.8 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.23 T273999_2 - 1.8e-10 40.3 6.8 1.8e-10 40.3 6.8 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) SPRY PF00622.26 T273999_2 - 5.2e-10 39.4 0.0 9.8e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_2 PF13923.4 T273999_2 - 3.5e-09 36.2 7.8 3.5e-09 36.2 7.8 4.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T273999_2 - 1.1e-07 31.9 8.2 1.1e-07 31.9 8.2 3.8 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_3 PF13920.4 T273999_2 - 1.5e-06 27.9 7.6 1.5e-06 27.9 7.6 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 T273999_2 - 1.6e-06 28.0 7.2 1.6e-06 28.0 7.2 3.6 4 1 0 4 4 4 1 B-box zinc finger zf-RING_5 PF14634.4 T273999_2 - 2.4e-05 24.1 5.4 2.4e-05 24.1 5.4 3.2 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_10 PF16685.3 T273999_2 - 5.2e-05 23.2 5.1 5.2e-05 23.2 5.1 2.5 1 1 0 2 2 2 1 zinc RING finger of MSL2 zf-Nse PF11789.6 T273999_2 - 0.11 12.2 5.9 0.095 12.4 3.9 2.0 2 0 0 2 2 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.5 T273999_2 - 1.4 9.2 15.8 0.15 12.2 3.7 3.6 3 0 0 3 3 3 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.4 T273999_2 - 3.2 7.5 24.9 0.071 12.8 10.6 3.8 3 1 1 4 4 4 0 Prokaryotic RING finger family 4 TBCC_N PF16752.3 T273999_2 - 5 7.4 9.6 8.2 6.8 3.9 2.4 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain SAM_1 PF00536.28 T028200_1 - 3.4e-24 84.9 1.2 9.3e-13 48.3 0.2 3.3 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T028200_1 - 7.8e-23 80.2 0.9 3e-09 36.7 0.1 3.3 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) Fanconi_C PF02106.13 T363006_1 - 2.2e-29 102.5 0.1 2.7e-29 102.2 0.1 1.1 1 0 0 1 1 1 1 Fanconi anaemia group C protein Fanconi_C PF02106.13 T363006_2 - 3.7e-224 745.5 7.7 5e-224 745.0 7.7 1.1 1 0 0 1 1 1 1 Fanconi anaemia group C protein PDZ PF00595.22 T244724_3 - 6.2e-65 215.4 5.6 4.7e-14 52.4 0.1 5.4 5 0 0 5 5 5 5 PDZ domain (Also known as DHR or GLGF) MAGI_u5 PF16666.3 T244724_3 - 9.4e-36 122.8 9.7 9.4e-36 122.8 9.7 3.2 2 0 0 2 2 2 1 Unstructured region on MAGI MAGI_u1 PF16663.3 T244724_3 - 2e-32 110.8 3.2 9.7e-32 108.6 3.2 2.3 1 0 0 1 1 1 1 Unstructured region on MAGI PDZ_2 PF13180.4 T244724_3 - 4e-29 100.6 0.0 3.9e-05 23.7 0.0 6.0 6 0 0 6 6 6 5 PDZ domain WW PF00397.24 T244724_3 - 5e-18 64.6 3.9 6.9e-10 38.6 0.4 2.7 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 T244724_3 - 3e-10 39.9 0.0 3e-10 39.9 0.0 2.2 2 0 0 2 2 2 1 Guanylate kinase Tricorn_PDZ PF14685.4 T244724_3 - 2.1e-07 30.7 4.8 0.17 11.8 0.0 4.8 5 0 0 5 5 5 3 Tricorn protease PDZ domain Serglycin PF04360.10 T244724_3 - 0.057 13.2 0.4 0.13 12.1 0.4 1.5 1 0 0 1 1 1 0 Serglycin DUF853 PF05872.10 T244724_3 - 1.9 6.9 4.0 3.2 6.1 4.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Mtc PF03820.15 T047896_1 - 4.1e-58 196.7 0.2 6.1e-58 196.2 0.2 1.2 1 0 0 1 1 1 1 Tricarboxylate carrier WBP-1 PF11669.6 T047896_1 - 1.4e-44 150.9 12.2 3.9e-44 149.4 12.2 1.9 1 0 0 1 1 1 1 WW domain-binding protein 1 Mtc PF03820.15 T047896_2 - 7.8e-58 195.8 0.1 1.3e-57 195.1 0.1 1.3 1 0 0 1 1 1 1 Tricarboxylate carrier Nsp1_C PF05064.11 T179010_1 - 2.6e-37 127.0 6.5 4.9e-37 126.2 6.5 1.4 1 0 0 1 1 1 1 Nsp1-like C-terminal region GAS PF13851.4 T179010_1 - 0.13 11.5 10.9 0.25 10.5 10.9 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4164 PF13747.4 T179010_1 - 0.14 12.3 5.1 0.052 13.7 1.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) HSR PF03172.11 T209346_2 - 8.8e-44 147.6 1.7 1.5e-43 146.8 1.7 1.4 1 0 0 1 1 1 1 HSR domain SAND PF01342.19 T209346_2 - 5.5e-31 106.0 0.1 1.1e-30 105.1 0.1 1.5 1 0 0 1 1 1 1 SAND domain Bromodomain PF00439.23 T209346_2 - 5e-07 29.6 0.1 1.1e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 Bromodomain PHD PF00628.27 T209346_2 - 2.6e-06 27.1 12.1 2.6e-06 27.1 12.1 2.6 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.4 T209346_2 - 0.076 12.4 4.9 0.22 10.9 4.9 1.8 1 0 0 1 1 1 0 PHD-finger DUF1725 PF08333.9 T209346_3 - 1.2e-06 27.9 0.4 2.8e-06 26.7 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) zf-H2C2_2 PF13465.4 T135650_1 - 9.7e-120 386.0 120.9 1.7e-08 34.4 0.5 17.7 18 0 0 18 18 18 16 Zinc-finger double domain zf-C2H2 PF00096.24 T135650_1 - 1.8e-74 242.1 115.7 3.8e-05 23.8 0.5 16.9 16 0 0 16 16 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T135650_1 - 2e-43 143.1 117.2 0.0053 17.3 0.4 17.2 17 0 0 17 17 17 16 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T135650_1 - 1.5e-16 59.7 82.4 0.00013 21.5 0.4 15.9 17 0 0 17 17 17 7 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T135650_1 - 4.8e-15 55.3 82.0 0.0079 16.2 1.2 10.8 3 2 11 14 14 14 13 Zinc ribbon domain zf-C2H2_6 PF13912.4 T135650_1 - 6.5e-13 48.2 94.4 0.2 11.5 0.1 16.6 16 0 0 16 16 16 11 C2H2-type zinc finger C1_4 PF07975.10 T135650_1 - 0.0002 21.4 79.2 0.14 12.3 0.2 11.1 3 2 11 14 14 14 5 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 T135650_1 - 0.00025 21.6 71.0 1.2 9.8 1.6 8.9 1 1 8 9 9 9 6 zinc-ribbon family Rapsyn_N PF10579.7 T135650_1 - 0.017 15.1 0.0 13 5.8 0.0 5.0 5 1 1 6 6 6 0 Rapsyn N-terminal myristoylation and linker region CpXC PF14353.4 T135650_1 - 2.6 8.0 64.6 9.6 6.1 0.0 14.6 2 2 12 15 15 15 0 CpXC protein KRAB PF01352.25 T135650_2 - 1e-24 85.8 0.1 1.9e-24 84.9 0.1 1.5 1 0 0 1 1 1 1 KRAB box Shugoshin_N PF07558.9 T238994_3 - 3.7e-11 42.6 2.2 7.2e-11 41.6 2.2 1.5 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.9 T238994_3 - 5.9e-10 38.6 1.3 1.7e-09 37.1 1.3 1.9 1 0 0 1 1 1 1 Shugoshin C terminus DUF2353 PF09789.7 T238994_3 - 0.091 12.0 6.4 0.13 11.6 6.4 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Aminotran_3 PF00202.19 T269353_3 - 1.2e-84 284.3 0.0 1.5e-84 283.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Synaphin PF05835.10 T119634_2 - 2.3e-44 151.0 8.4 3.1e-44 150.6 8.4 1.2 1 0 0 1 1 1 1 Synaphin protein Lectin_leg-like PF03388.11 T119634_3 - 2.8e-34 118.3 0.0 4e-34 117.8 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family DALR_1 PF05746.13 T242383_3 - 4.8e-15 55.7 0.0 7.3e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 DALR anticodon binding domain MFS_2 PF13347.4 T047848_2 - 6.4e-19 67.7 10.3 7.2e-11 41.1 0.5 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein SRF-TF PF00319.16 T170855_2 - 6.1e-23 79.9 0.3 8.7e-23 79.4 0.3 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) NEP PF10167.7 T170855_3 - 8.1e-40 135.1 0.1 1.2e-39 134.6 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein Pkinase_Tyr PF07714.15 T222406_1 - 8.1e-59 198.9 0.0 1.2e-58 198.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T222406_1 - 4e-29 101.6 0.0 5.8e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T222406_2 - 0.0055 15.9 0.0 0.0081 15.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SH2 PF00017.22 T222406_2 - 0.16 12.0 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 SH2 domain Pkinase_Tyr PF07714.15 T222406_3 - 2.3e-96 321.9 0.0 6.1e-78 261.6 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.23 T222406_3 - 1.4e-41 142.5 0.0 3.2e-39 134.8 0.0 2.9 3 0 0 3 3 3 1 Protein kinase domain SH3_1 PF00018.26 T222406_3 - 1.3e-07 30.9 0.2 2.9e-07 29.8 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T222406_3 - 5.6e-07 29.2 0.1 1.3e-06 28.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T222406_3 - 5.9e-06 25.7 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH2 PF00017.22 T222406_3 - 0.0025 17.7 0.0 0.0046 16.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain Activin_recp PF01064.21 T079259_1 - 0.53 11.3 6.4 0.36 11.8 3.7 2.2 2 0 0 2 2 2 0 Activin types I and II receptor domain Pkinase PF00069.23 T079259_2 - 1.4e-20 73.7 0.0 2.1e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T079259_2 - 6.3e-18 64.9 0.0 1.2e-17 63.9 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 T079259_2 - 0.019 14.8 1.0 0.066 13.0 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family UCH PF00443.27 T081129_3 - 3.7e-85 285.4 0.3 5.4e-85 284.9 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.4 T081129_3 - 2.3e-38 129.8 0.1 3.8e-38 129.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.10 T081129_3 - 1.4e-20 73.6 1.4 3.6e-20 72.2 1.4 1.8 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.4 T081129_3 - 1.6e-17 64.0 0.0 3.2e-10 40.0 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.4 T081129_3 - 1.7e-07 31.0 0.3 9.1e-07 28.7 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal CW_binding_1 PF01473.18 T081129_3 - 0.55 10.5 4.7 2 8.8 4.7 1.9 1 0 0 1 1 1 0 Putative cell wall binding repeat MRP-S26 PF14943.4 T212787_1 - 2.3e-50 170.7 16.5 3.1e-50 170.3 16.5 1.2 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S26 Y_phosphatase PF00102.25 T212787_3 - 1.4e-166 551.6 9.2 5.8e-84 281.2 0.5 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Hormone_5 PF00184.15 T212787_3 - 5.6e-30 103.9 25.0 5.6e-30 103.9 25.0 3.4 4 0 0 4 4 4 1 Neurohypophysial hormones, C-terminal Domain DSPc PF00782.18 T212787_3 - 7.3e-08 32.2 0.8 0.0061 16.2 0.3 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 T212787_3 - 2.3e-07 30.9 0.0 0.0022 17.9 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 T212787_3 - 4.7e-05 23.4 0.3 0.044 13.8 0.1 2.5 2 0 0 2 2 2 2 Inositol hexakisphosphate Hormone_4 PF00220.15 T212787_3 - 0.78 9.7 10.7 0.036 13.9 3.9 2.6 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain PCRF PF03462.16 T093445_3 - 1e-48 165.6 0.9 1e-48 165.6 0.9 1.6 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.18 T093445_3 - 3.7e-39 133.1 3.5 3.7e-39 133.1 3.5 2.4 2 1 0 2 2 2 1 RF-1 domain L27_1 PF09058.8 T093445_3 - 0.0048 16.8 1.3 0.0048 16.8 1.3 2.1 2 0 0 2 2 2 1 L27_1 BLOC1_2 PF10046.7 T093445_3 - 0.045 13.9 3.0 0.11 12.6 3.0 1.7 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1910 PF08928.8 T093445_3 - 0.5 10.2 5.0 2.7 7.9 0.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) PLA2_B PF01735.16 T115123_1 - 5.9e-28 97.4 0.0 3.5e-27 94.8 0.0 1.9 2 0 0 2 2 2 1 Lysophospholipase catalytic domain C2 PF00168.28 T115123_2 - 2.6e-17 62.9 0.0 4.1e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 C2 domain Cupin_8 PF13621.4 T115123_3 - 1.3e-75 254.4 0.0 1.6e-75 254.0 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.20 T115123_3 - 0.02 15.2 0.0 0.037 14.3 0.0 1.3 1 0 0 1 1 1 0 JmjC domain, hydroxylase Glyco_hydro_20 PF00728.20 T157033_2 - 3e-08 33.3 0.0 4.8e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain zf-C3HC4_2 PF13923.4 T160583_3 - 7.6e-14 51.1 10.4 7.6e-14 51.1 10.4 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Di19 PF05605.10 T160583_3 - 6.5e-13 48.6 2.3 6.5e-13 48.6 2.3 3.3 3 1 0 3 3 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C3HC4 PF00097.23 T160583_3 - 6.2e-08 32.2 9.6 6.2e-08 32.2 9.6 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T160583_3 - 6.2e-07 29.5 9.6 6.2e-07 29.5 9.6 3.9 3 1 1 4 4 3 1 Ring finger domain zf-RING_5 PF14634.4 T160583_3 - 1.1e-06 28.4 9.1 1.1e-06 28.4 9.1 3.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 T160583_3 - 3.5e-06 26.8 9.0 3.5e-06 26.8 9.0 3.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 T160583_3 - 3.8e-06 26.5 7.1 3.8e-06 26.5 7.1 4.5 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.6 T160583_3 - 6.1e-05 22.6 3.7 6.1e-05 22.6 3.7 2.1 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.4 T160583_3 - 6.5e-05 22.9 8.4 6.5e-05 22.9 8.4 3.6 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.4 T160583_3 - 8.1e-05 22.3 6.7 8.1e-05 22.3 6.7 4.2 3 1 1 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.4 T160583_3 - 0.0019 17.9 3.4 0.0019 17.9 3.4 2.5 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.4 T160583_3 - 0.1 12.2 15.2 0.071 12.7 9.0 3.7 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain zf-MIZ PF02891.18 T160583_3 - 0.69 9.6 19.0 0.01 15.5 7.1 3.1 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger zf-UDP PF14569.4 T160583_3 - 0.97 9.5 5.2 3 7.9 5.2 1.9 1 0 0 1 1 1 0 Zinc-binding RING-finger SNF PF00209.16 T277625_2 - 5.7e-112 374.9 16.8 7.4e-112 374.6 16.8 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.16 T277625_3 - 3.2e-73 247.1 3.8 4.3e-73 246.7 3.8 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Acyltransferase PF01553.19 T277625_3 - 3.7e-15 55.6 0.0 6.2e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase EF-hand_8 PF13833.4 T277625_3 - 2.5e-10 39.8 1.0 6e-08 32.2 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.4 T277625_3 - 1.8e-06 28.2 0.3 0.00026 21.3 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 T277625_3 - 2e-06 27.2 0.1 0.034 14.0 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 T277625_3 - 1.3e-05 24.3 0.4 0.056 12.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.4 T277625_3 - 0.81 9.2 1.8 26 4.4 0.2 2.3 2 0 0 2 2 2 0 EF hand DnaJ PF00226.29 T078135_3 - 4.6e-16 58.5 0.1 8e-16 57.8 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain TM2 PF05154.14 T078135_3 - 1.4e-06 28.4 10.8 4.3e-06 26.8 10.8 1.9 1 0 0 1 1 1 1 TM2 domain Pkinase PF00069.23 T281732_1 - 3.9e-69 232.8 0.0 5.2e-69 232.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T281732_1 - 3.2e-39 134.7 0.0 4.2e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T281732_1 - 2.9e-09 36.5 0.0 4.2e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 T281732_1 - 0.0044 16.5 0.1 0.0072 15.8 0.1 1.2 1 0 0 1 1 1 1 RIO1 family FlgM PF04316.11 T281732_1 - 0.0062 16.7 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 Anti-sigma-28 factor, FlgM Kdo PF06293.12 T281732_1 - 0.027 13.7 0.0 0.043 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-H2C2_2 PF13465.4 T281732_2 - 1.7e-12 47.1 27.9 4.1e-07 30.0 6.2 4.7 4 0 0 4 4 4 4 Zinc-finger double domain zf-met PF12874.5 T281732_2 - 2.6e-07 30.7 5.4 0.00023 21.3 0.6 5.5 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 T281732_2 - 5.1e-06 26.7 32.6 0.1 13.3 0.3 5.6 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.24 T281732_2 - 0.00027 21.1 36.7 0.14 12.6 0.1 5.5 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 T281732_2 - 0.00066 19.8 0.9 0.00066 19.8 0.9 5.1 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T281732_2 - 0.4 10.5 28.9 0.65 9.9 0.1 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger PyrI_C PF02748.13 T281732_2 - 5.5 6.8 8.0 1.4 8.7 0.3 3.0 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain AA_kinase PF00696.26 T046558_2 - 4.2e-40 137.7 0.6 6.2e-40 137.2 0.6 1.3 1 0 0 1 1 1 1 Amino acid kinase family Aldedh PF00171.20 T046558_2 - 5e-11 41.7 0.0 2.4e-08 32.8 0.0 2.2 2 0 0 2 2 2 2 Aldehyde dehydrogenase family DUF1619 PF07773.9 T046558_3 - 1.3e-83 281.5 10.2 6.4e-83 279.2 5.7 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) EF-hand_7 PF13499.4 T034439_1 - 1.2e-05 25.6 0.1 2.6e-05 24.5 0.1 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.4 T034439_1 - 0.00051 20.2 0.0 0.0071 16.5 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_6 PF13405.4 T034439_1 - 0.038 13.8 0.0 0.089 12.7 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain Pkinase PF00069.23 T001094_3 - 3.7e-64 216.5 0.0 4.8e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T001094_3 - 2.7e-33 115.2 0.0 5e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 T001094_3 - 1.3e-18 66.6 0.0 2.7e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 PB1 domain C1_1 PF00130.20 T001094_3 - 7.4e-15 54.4 6.6 1.4e-14 53.6 6.6 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 T001094_3 - 5.2e-06 26.9 2.1 1.4e-05 25.5 2.1 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 T001094_3 - 5.3e-05 22.5 0.0 0.00011 21.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like C1_2 PF03107.14 T001094_3 - 0.0056 16.8 4.7 0.099 12.8 2.1 2.4 2 0 0 2 2 2 1 C1 domain APH PF01636.21 T001094_3 - 0.037 13.8 0.1 0.17 11.7 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.4 T001094_3 - 0.046 13.2 0.2 1.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 T001094_3 - 0.049 12.9 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DZR PF12773.5 T001094_3 - 0.14 12.1 1.5 0.37 10.7 1.5 1.7 1 0 0 1 1 1 0 Double zinc ribbon 7tm_4 PF13853.4 T100321_2 - 2.8e-50 171.5 18.1 4.2e-50 170.9 18.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T100321_2 - 2.1e-18 66.4 20.8 7.1e-18 64.7 20.8 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Xan_ur_permease PF00860.18 T289861_1 - 2.9e-87 292.8 24.3 3.9e-87 292.3 24.3 1.2 1 0 0 1 1 1 1 Permease family DUF4585 PF15232.4 T289861_1 - 1.6e-20 72.8 1.2 3.5e-20 71.7 1.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4585) ECSCR PF15820.3 T289861_1 - 5.6e-11 42.0 0.7 1.1e-10 41.2 0.7 1.4 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator DUF1977 PF09320.9 T289861_2 - 1.4e-23 83.0 0.8 1.4e-23 83.0 0.8 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) DnaJ PF00226.29 T289861_2 - 6.8e-23 80.4 0.1 1.2e-22 79.7 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain SPATA24 PF15175.4 T289861_2 - 8.1e-06 25.7 0.8 1.5e-05 24.9 0.8 1.4 1 0 0 1 1 1 1 Spermatogenesis-associated protein 24 SPATA24 PF15175.4 T289861_3 - 6.7e-65 218.3 21.0 1.2e-64 217.4 21.0 1.3 1 0 0 1 1 1 1 Spermatogenesis-associated protein 24 Collagen PF01391.16 T208945_1 - 2.1e-105 344.3 447.6 7.5e-10 38.3 28.0 16.7 7 5 9 16 16 16 15 Collagen triple helix repeat (20 copies) C4 PF01413.17 T208945_1 - 1.1e-10 41.7 0.0 1.7e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 C-terminal tandem repeated domain in type 4 procollagen Collagen PF01391.16 T208945_2 - 3.3e-63 209.2 280.2 5.1e-10 38.8 25.8 11.7 4 3 7 11 11 11 10 Collagen triple helix repeat (20 copies) JAB PF01398.19 T349994_2 - 7.4e-23 80.6 0.6 7.4e-23 80.6 0.6 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease START PF01852.17 T284432_2 - 6.8e-30 103.9 0.5 1.1e-29 103.2 0.5 1.3 1 0 0 1 1 1 1 START domain PH PF00169.27 T284432_2 - 6.3e-15 55.4 0.5 1.5e-14 54.3 0.5 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 T284432_2 - 1.2e-07 31.8 0.2 1e-06 28.8 0.1 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.4 T284432_2 - 4.7e-05 23.6 2.2 0.0015 18.8 2.2 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain Homeobox PF00046.27 T010312_1 - 2.6e-21 75.1 3.6 4.8e-21 74.2 3.6 1.4 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 T010312_1 - 6.3e-05 22.5 1.2 0.00013 21.5 1.2 1.6 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 T010312_1 - 0.082 12.7 0.1 0.21 11.4 0.1 1.7 1 0 0 1 1 1 0 Homeobox KN domain Sugar_tr PF00083.22 T368338_1 - 2.4e-22 79.3 0.0 3.5e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Sugar_tr PF00083.22 T368338_3 - 1.1e-47 162.8 20.4 2.2e-27 95.9 5.5 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 T368338_3 - 4e-14 52.2 34.9 2.1e-13 49.8 17.6 2.5 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.5 T368338_3 - 0.046 12.4 0.0 0.086 11.5 0.0 1.3 1 0 0 1 1 1 0 MFS_1 like family WD40_4 PF16300.3 T144901_1 - 9.6e-21 73.3 0.2 1.9e-20 72.3 0.2 1.5 1 0 0 1 1 1 1 Type of WD40 repeat DUF1899 PF08953.9 T144901_2 - 1.5e-29 101.6 0.0 2.7e-29 100.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.30 T144901_2 - 7.8e-13 48.6 5.4 0.0013 19.4 0.2 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T144901_2 - 2.4e-07 30.8 0.1 0.002 18.3 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DSPc PF00782.18 T144901_3 - 8.8e-33 112.8 0.0 1.5e-32 112.0 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.9 T144901_3 - 4.8e-10 39.1 5.1 8.6e-10 38.3 5.1 1.4 1 0 0 1 1 1 1 DEK C terminal domain PB1 PF00564.22 T246857_3 - 1.6e-11 43.8 0.2 2.7e-11 43.1 0.2 1.4 1 0 0 1 1 1 1 PB1 domain MucBP PF06458.10 T246857_3 - 0.22 12.5 3.4 7.3 7.6 0.0 3.0 2 1 0 2 2 2 0 MucBP domain Cofilin_ADF PF00241.18 T077248_2 - 9.8e-39 132.3 0.5 5.1e-21 75.0 0.3 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein zf-C2H2 PF00096.24 T214422_1 - 1.1e-79 258.5 104.3 3.8e-07 30.1 0.4 15.8 16 0 0 16 16 15 15 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T214422_1 - 2.8e-77 251.8 80.5 3.2e-06 27.2 0.4 15.9 15 1 1 16 16 16 14 Zinc-finger double domain zf-C2H2_4 PF13894.4 T214422_1 - 5.8e-47 154.1 101.4 0.0039 17.8 0.3 16.2 16 0 0 16 16 16 15 C2H2-type zinc finger KRAB PF01352.25 T214422_1 - 9.7e-25 85.8 0.1 1.7e-24 85.1 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 T214422_1 - 1.2e-13 50.9 33.5 4.1 7.7 0.0 13.7 14 0 0 14 14 14 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T214422_1 - 3.2e-09 36.4 88.8 0.023 14.5 1.6 15.0 14 1 0 14 14 14 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T214422_1 - 1.3e-08 34.7 60.2 0.03 14.3 0.8 10.3 2 2 9 12 12 12 6 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T214422_1 - 6.6e-08 33.1 45.0 0.41 11.3 0.4 7.9 1 1 7 8 8 8 6 zinc-ribbon family ADK_lid PF05191.12 T214422_1 - 3.8e-06 26.7 50.1 0.033 14.1 0.5 10.5 5 2 6 11 11 11 5 Adenylate kinase, active site lid zf-C2H2_11 PF16622.3 T214422_1 - 1.5e-05 24.5 82.6 0.21 11.3 0.8 14.8 15 0 0 15 15 15 6 zinc-finger C2H2-type DUF3268 PF11672.6 T214422_1 - 0.002 18.3 43.0 0.38 11.0 1.2 8.2 4 2 3 9 9 9 4 zinc-finger-containing domain Chordopox_RPO7 PF05864.10 T214422_1 - 0.012 15.8 28.6 24 5.1 0.7 10.4 10 1 1 11 11 11 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zf-trcl PF13451.4 T214422_1 - 0.013 15.3 52.8 4.2 7.2 0.1 13.4 14 1 0 14 14 14 0 Probable zinc-ribbon domain BHD_1 PF10403.7 T214422_1 - 0.078 12.7 0.1 1.5 8.6 0.0 3.2 5 1 0 5 5 5 0 Rad4 beta-hairpin domain 1 zf-met PF12874.5 T214422_1 - 1.1 9.6 70.6 3.7 7.9 0.1 13.7 14 0 0 14 14 14 0 Zinc-finger of C2H2 type DUF2799 PF10973.6 T214422_2 - 0.33 11.3 3.7 0.74 10.2 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2799) P53 PF00870.16 T001664_1 - 4e-112 372.4 0.2 6e-112 371.8 0.2 1.3 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 T001664_1 - 1.7e-18 65.5 0.5 3e-18 64.7 0.5 1.3 1 0 0 1 1 1 1 P53 tetramerisation motif SAM_2 PF07647.15 T001664_3 - 4.4e-09 36.2 0.0 8.4e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 T001664_3 - 0.0023 18.2 0.0 0.004 17.4 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Mit_proteolip PF08039.9 T304631_1 - 1.1 9.5 5.0 3.2 8.0 5.0 1.7 1 0 0 1 1 1 0 Mitochondrial proteolipid Mito_carr PF00153.25 T304631_3 - 5.5e-52 173.5 0.1 3.3e-20 71.7 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein RPAP2_Rtr1 PF04181.11 T304631_3 - 0.011 15.9 0.5 0.02 15.1 0.5 1.3 1 0 0 1 1 1 0 Rtr1/RPAP2 family AAA_11 PF13086.4 T222487_3 - 5.9e-74 249.0 0.0 4.3e-52 177.3 0.0 3.3 2 1 1 3 3 3 3 AAA domain AAA_12 PF13087.4 T222487_3 - 2.3e-70 236.1 0.0 7.3e-43 146.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain RNB PF00773.17 T222487_3 - 7.5e-50 170.0 0.0 1.2e-49 169.3 0.0 1.3 1 0 0 1 1 1 1 RNB domain AAA_30 PF13604.4 T222487_3 - 1.8e-18 66.8 0.0 7.1e-05 22.5 0.0 4.5 4 0 0 4 4 4 3 AAA domain AAA_19 PF13245.4 T222487_3 - 1.2e-14 54.8 0.0 1.6e-06 28.4 0.0 4.0 4 0 0 4 4 4 2 AAA domain UvrD_C_2 PF13538.4 T222487_3 - 7.2e-07 28.8 1.1 0.00026 20.6 0.1 3.2 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.4 T222487_3 - 1.6e-06 28.3 0.0 0.025 14.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain PhoH PF02562.14 T222487_3 - 7.8e-06 25.4 0.0 2.1 7.6 0.0 4.2 4 0 0 4 4 4 2 PhoH-like protein ResIII PF04851.13 T222487_3 - 0.00067 19.6 0.0 1.4 8.8 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit UvrD_C PF13361.4 T222487_3 - 0.002 17.5 0.0 0.013 14.8 0.0 2.1 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.16 T222487_3 - 0.002 17.8 4.2 0.25 10.9 0.0 3.5 4 0 0 4 4 4 1 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.19 T222487_3 - 0.0032 16.9 0.0 0.15 11.4 0.0 2.7 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain DUF2075 PF09848.7 T222487_3 - 0.0053 15.9 0.0 0.028 13.5 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) zf-C2H2_jaz PF12171.6 T222487_3 - 0.0093 16.1 2.9 0.019 15.1 2.9 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding AAA_24 PF13479.4 T222487_3 - 0.072 12.7 0.1 0.77 9.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA PF00004.27 T222487_3 - 0.091 13.1 1.2 13 6.1 0.1 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.16 T222487_3 - 0.14 11.8 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein zf-CCCH PF00642.22 T222487_3 - 0.59 10.0 5.7 2.5 8.0 1.9 3.2 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-met PF12874.5 T222487_3 - 1.5 9.2 4.3 4.2 7.7 4.3 1.9 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.24 T365162_3 - 2e-05 24.7 28.3 0.47 10.9 2.9 5.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type Dimer_Tnp_hAT PF05699.12 T365162_3 - 0.0082 15.8 0.1 0.0082 15.8 0.1 2.1 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region zf-H2C2_2 PF13465.4 T365162_3 - 0.009 16.3 14.2 4.9 7.6 0.1 5.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 T365162_3 - 0.049 14.4 42.8 0.091 13.5 2.3 6.9 6 0 0 6 6 6 0 C2H2-type zinc finger Neur_chan_memb PF02932.14 T209761_1 - 1.2e-57 195.6 0.1 1.7e-57 195.1 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 T209761_1 - 3.4e-07 29.8 0.0 5e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_LBD PF02931.21 T209761_2 - 1.5e-52 178.0 1.4 2.2e-52 177.5 1.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Rhomboid PF01694.20 T123992_2 - 2.4e-28 98.9 8.6 2.4e-28 98.9 8.6 1.6 2 0 0 2 2 2 1 Rhomboid family Rhomboid_SP PF12595.6 T123992_2 - 3.8e-08 32.8 0.0 6.7e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Rhomboid serine protease Rhomboid_SP PF12595.6 T123992_3 - 7.5e-94 313.0 7.4 7.5e-94 313.0 7.4 2.0 2 0 0 2 2 2 1 Rhomboid serine protease Tubulin-binding PF00418.17 T241990_3 - 3.9e-40 135.4 16.5 6.3e-15 54.8 6.2 3.7 3 0 0 3 3 3 3 Tau and MAP protein, tubulin-binding repeat ABC_tran PF00005.25 T208018_2 - 3.6e-34 118.1 0.0 5e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.21 T208018_2 - 6.5e-29 101.3 10.8 8.9e-29 100.8 10.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.17 T208018_2 - 2.2e-06 27.1 0.1 3.2e-05 23.3 0.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 T208018_2 - 0.0022 18.3 0.0 0.0043 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 T208018_2 - 0.0026 17.6 0.0 0.0048 16.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 T208018_2 - 0.0071 15.9 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.4 T208018_2 - 0.011 15.8 0.0 0.03 14.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.4 T208018_2 - 0.037 13.7 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.27 T208018_2 - 0.073 13.4 0.0 0.44 10.8 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF3413 PF11893.6 T208018_2 - 0.62 9.0 4.8 1.1 8.3 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) APG9 PF04109.14 T208018_3 - 2.2e-130 435.0 0.4 3e-130 434.5 0.4 1.2 1 0 0 1 1 1 1 Autophagy protein Apg9 MTABC_N PF16185.3 T208018_3 - 4e-64 216.3 0.0 8e-64 215.3 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region PRRSV_2b PF07069.9 T208018_3 - 0.11 12.9 1.1 0.31 11.4 1.1 1.7 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b Methyltransf_23 PF13489.4 T213988_1 - 0.0011 18.7 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 T213988_1 - 0.037 14.5 0.0 0.069 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.4 T213988_3 - 0.031 14.9 0.1 0.12 13.0 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.10 T213988_3 - 0.16 12.5 0.0 0.64 10.6 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain FYRC PF05965.12 T068336_2 - 1.9e-21 75.9 0.0 4.6e-21 74.6 0.0 1.7 1 0 0 1 1 1 1 F/Y rich C-terminus SET PF00856.26 T068336_2 - 2.8e-21 76.5 0.7 2.8e-21 76.5 0.7 3.2 4 0 0 4 4 2 1 SET domain PHD PF00628.27 T068336_2 - 3.2e-16 58.8 74.7 2.5e-08 33.5 12.0 5.3 3 1 2 5 5 5 3 PHD-finger C2-set_2 PF08205.10 T068336_2 - 5e-16 58.4 0.2 7e-14 51.5 0.0 3.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain FYRN PF05964.12 T068336_2 - 7.2e-16 57.7 0.1 1.8e-15 56.4 0.1 1.8 1 0 0 1 1 1 1 F/Y-rich N-terminus zf-CXXC PF02008.18 T068336_2 - 6.6e-13 48.3 23.6 6.6e-13 48.3 23.6 4.9 4 1 1 5 5 1 1 CXXC zinc finger domain zf-HC5HC2H PF13771.4 T068336_2 - 6.9e-10 38.9 10.0 6.9e-10 38.9 10.0 5.3 4 1 1 5 5 2 1 PHD-like zinc-binding domain TPR_2 PF07719.15 T068336_2 - 2e-06 27.4 2.8 0.012 15.5 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.26 T068336_2 - 6.3e-06 25.7 0.1 0.0028 17.3 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 T068336_2 - 1.6e-05 25.0 3.8 1.6e-05 25.0 3.8 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat PHD_2 PF13831.4 T068336_2 - 0.00075 18.8 22.8 0.039 13.4 2.5 4.0 3 0 0 3 3 3 2 PHD-finger TPR_9 PF13371.4 T068336_2 - 0.0019 18.2 2.4 0.0019 18.2 2.4 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.4 T068336_2 - 0.0038 16.8 0.2 0.089 12.4 0.1 2.5 1 1 1 2 2 2 1 TPR repeat Bromodomain PF00439.23 T068336_2 - 0.0078 16.1 0.0 0.023 14.6 0.0 1.7 1 0 0 1 1 1 1 Bromodomain TPR_16 PF13432.4 T068336_2 - 0.02 15.5 14.2 0.0041 17.6 3.5 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.4 T068336_2 - 0.12 12.1 8.4 0.13 12.1 1.7 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.4 T068336_2 - 0.63 10.5 2.0 1.7 9.1 2.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3915 PF13054.4 T068336_2 - 3.3 7.6 5.6 9.4 6.1 5.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Choline_transpo PF04515.10 T013364_1 - 2e-106 355.8 28.5 2e-106 355.8 28.5 2.9 4 0 0 4 4 4 1 Plasma-membrane choline transporter STAR_dimer PF16544.3 T314903_1 - 1.3e-26 91.7 0.1 2.3e-26 91.0 0.1 1.4 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein Quaking_NLS PF16551.3 T314903_1 - 4.4e-16 58.1 4.9 7.2e-16 57.4 4.9 1.4 1 0 0 1 1 1 1 Putative nuclear localisation signal of quaking KH_1 PF00013.27 T314903_1 - 2.8e-05 23.7 0.0 5e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 KH domain Complex1_30kDa PF00329.17 T058318_1 - 8.5e-44 149.0 0.0 1.3e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit FAM180 PF15173.4 T058318_3 - 1.5e-32 112.3 0.2 2.2e-32 111.8 0.2 1.2 1 0 0 1 1 1 1 FAM180 family TRM PF02005.14 T169144_2 - 6.6e-151 502.6 0.0 8.3e-151 502.3 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase zf-CCCH PF00642.22 T169144_2 - 1.4e-06 27.9 5.9 3.9e-06 26.5 5.9 1.9 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Met_10 PF02475.14 T169144_2 - 1.7e-05 24.5 0.0 2.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Torus PF16131.3 T169144_2 - 0.0017 18.9 0.4 0.0043 17.6 0.4 1.6 1 0 0 1 1 1 1 Torus domain Cons_hypoth95 PF03602.13 T169144_2 - 0.014 14.9 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 HLH PF00010.24 T169144_3 - 1.3e-13 50.5 0.0 1.3e-13 50.5 0.0 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Steroid_dh PF02544.14 T187325_2 - 2.6e-61 205.9 1.7 4.1e-61 205.2 1.7 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.10 T187325_2 - 0.0024 17.3 0.1 0.004 16.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PHF5 PF03660.12 T248292_1 - 7e-07 29.3 0.2 1.3e-06 28.4 0.2 1.4 1 0 0 1 1 1 1 PHF5-like protein PHF5 PF03660.12 T248292_2 - 1.1e-14 54.3 7.9 1.8e-14 53.6 7.9 1.3 1 0 0 1 1 1 1 PHF5-like protein PHF5 PF03660.12 T248292_3 - 0.0024 17.9 1.0 0.0024 17.9 1.0 1.8 2 0 0 2 2 2 1 PHF5-like protein Ion_trans PF00520.29 T062557_2 - 5.4e-52 176.3 48.1 1.5e-28 99.5 21.1 2.8 3 0 0 3 3 3 2 Ion transport protein DUF4147 PF13660.4 T243302_2 - 2.6e-50 171.0 0.5 3.8e-50 170.4 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) DUF4147 PF13660.4 T243302_3 - 1.1e-25 90.4 0.0 1.6e-25 89.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) Ank_3 PF13606.4 T204623_1 - 0.036 14.5 0.1 0.09 13.2 0.1 1.7 1 0 0 1 1 1 0 Ankyrin repeat Asn_synthase PF00733.19 T204623_2 - 7.7e-16 58.6 0.0 5.9e-08 32.6 0.0 3.1 2 1 0 2 2 2 2 Asparagine synthase GATase_7 PF13537.4 T204623_2 - 6.3e-05 22.8 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Prefoldin_2 PF01920.18 T204623_2 - 0.45 10.4 6.6 0.83 9.5 6.6 1.4 1 0 0 1 1 1 0 Prefoldin subunit Arm PF00514.21 T204623_3 - 9e-17 60.4 11.6 0.0033 17.3 0.1 6.8 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat Ank_4 PF13637.4 T204623_3 - 0.0042 17.5 0.0 0.012 16.0 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) HEAT_EZ PF13513.4 T204623_3 - 0.0067 16.7 0.1 1.8 9.0 0.0 4.0 4 0 0 4 4 4 1 HEAT-like repeat Ank_2 PF12796.5 T204623_3 - 0.009 16.5 0.0 0.031 14.7 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Atx10homo_assoc PF09759.7 T204623_3 - 0.027 14.4 5.1 0.07 13.1 2.0 2.9 3 1 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Ank_3 PF13606.4 T204623_3 - 0.048 14.1 0.0 1.2 9.8 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeat Mit_proteolip PF08039.9 T152891_1 - 1.7 8.9 4.7 4.4 7.6 4.7 1.7 1 0 0 1 1 1 0 Mitochondrial proteolipid IP_trans PF02121.16 T152891_3 - 4.8e-110 366.8 4.8 6.4e-110 366.4 4.8 1.1 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein ABA_GPCR PF12430.6 T019489_1 - 2.2e-13 50.3 1.8 3.7e-13 49.5 1.8 1.3 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.6 T019489_2 - 4.4e-28 97.0 0.1 9.6e-28 96.0 0.1 1.6 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal ABA_GPCR PF12430.6 T019489_2 - 8.6e-21 74.4 6.4 8.6e-21 74.4 6.4 1.8 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor Cyclin_N PF00134.21 T000747_1 - 4.4e-09 36.1 0.0 6.9e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 T000747_3 - 6.2e-05 22.9 0.0 0.0001 22.2 0.0 1.2 1 0 0 1 1 1 1 Cyclin, C-terminal domain Cyclin_C_2 PF16899.3 T000747_3 - 0.095 13.0 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Cyclin C-terminal domain Cyclin_N PF00134.21 T000747_3 - 0.13 12.0 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Cyclin, N-terminal domain DUF4559 PF15112.4 T373438_1 - 9.1e-102 340.8 0.9 1.3e-101 340.3 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4559) Med14 PF08638.9 T373438_3 - 3.3e-54 183.1 0.0 6.4e-54 182.2 0.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit MED14 DUF773 PF05600.10 T149540_1 - 2e-74 251.1 0.3 2.6e-74 250.7 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF773) DUF773 PF05600.10 T149540_2 - 4.1e-37 128.0 0.1 5.8e-37 127.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF773) DUF773 PF05600.10 T149540_3 - 1.5e-53 182.2 0.6 2e-53 181.8 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF773) zf-C4 PF00105.16 T084350_1 - 1.3e-31 108.7 15.4 3.2e-31 107.5 15.4 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) DUF2318 PF10080.7 T084350_1 - 0.023 14.7 0.2 0.023 14.7 0.2 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) zf-GRF PF06839.10 T269744_2 - 1.5e-13 50.4 0.3 4.1e-13 49.1 0.3 1.8 1 0 0 1 1 1 1 GRF zinc finger AAA_11 PF13086.4 T269744_2 - 1.4e-05 24.8 0.0 2.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.4 T269744_3 - 1.7e-50 171.3 0.7 4.8e-50 169.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF2439 PF10382.7 T269744_3 - 1.2e-19 70.2 0.6 5.4e-19 68.2 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) AAA_11 PF13086.4 T269744_3 - 0.00024 20.8 0.0 0.00024 20.8 0.0 3.2 4 0 0 4 4 4 1 AAA domain Viral_helicase1 PF01443.16 T269744_3 - 0.082 12.5 0.1 2.4 7.7 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase 2OG-FeII_Oxy_2 PF13532.4 T143196_1 - 1.5e-08 35.0 0.0 2.9e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SH3_2 PF07653.15 T143196_1 - 4.8e-06 26.0 0.0 9.7e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain MyTH4 PF00784.15 T143196_3 - 6e-25 87.7 0.1 1.4e-24 86.5 0.1 1.7 1 0 0 1 1 1 1 MyTH4 domain FERM_M PF00373.16 T143196_3 - 2.6e-07 30.9 0.6 4.3e-07 30.2 0.6 1.4 1 0 0 1 1 1 1 FERM central domain SH3_2 PF07653.15 T143196_3 - 0.0015 18.0 0.1 0.0033 17.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SFTA2 PF15210.4 T300699_1 - 9.7e-34 115.0 3.4 1.7e-33 114.2 3.4 1.4 1 0 0 1 1 1 1 Surfactant-associated protein 2 SNF PF00209.16 T277524_2 - 3.5e-50 171.1 6.4 1.2e-42 146.1 0.5 3.0 3 0 0 3 3 3 3 Sodium:neurotransmitter symporter family SNF PF00209.16 T277524_3 - 1.6e-25 89.7 0.3 2.2e-25 89.3 0.3 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SHIPPO-rpt PF07004.10 T119899_2 - 0.014 16.2 15.1 4.8 8.1 0.0 5.8 5 0 0 5 5 5 0 Sperm-tail PG-rich repeat EF-hand_7 PF13499.4 T052560_1 - 3.8e-05 24.0 0.1 5.9e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T052560_1 - 9.5e-05 21.9 0.0 0.38 10.7 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain Tetraspannin PF00335.18 T052560_3 - 4.9e-48 163.6 12.0 7.2e-48 163.0 12.0 1.3 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.13 T052560_3 - 2.1e-05 24.5 0.4 4.2e-05 23.6 0.4 1.4 1 0 0 1 1 1 1 CD20-like family DUF4199 PF13858.4 T052560_3 - 0.001 19.4 0.8 0.0019 18.5 0.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) SUR7 PF06687.10 T052560_3 - 0.018 14.6 3.0 0.034 13.6 3.0 1.4 1 0 0 1 1 1 0 SUR7/PalI family DUF2569 PF10754.7 T052560_3 - 1.5 9.1 5.3 2.5 8.4 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) DUF3040 PF11239.6 T052560_3 - 3.3 7.9 5.5 17 5.6 5.5 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) PDZ PF00595.22 T374615_1 - 5.6e-05 23.3 0.0 0.00011 22.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SNF2_N PF00176.21 T199939_2 - 3.6e-24 85.0 0.0 5.1e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.13 T199939_2 - 2.9e-09 37.0 0.0 3.6e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.27 T199939_2 - 0.00084 19.0 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.12 T199939_2 - 0.003 17.4 0.0 0.0046 16.8 0.0 1.2 1 0 0 1 1 1 1 Flavivirus DEAD domain Transketolase_C PF02780.18 T199939_2 - 0.049 13.4 0.0 0.48 10.2 0.0 2.1 2 0 0 2 2 2 0 Transketolase, C-terminal domain AAA_22 PF13401.4 T199939_2 - 0.088 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Terminase_1 PF03354.13 T199939_2 - 0.15 10.5 0.0 0.21 10.0 0.0 1.1 1 0 0 1 1 1 0 Phage Terminase EF-hand_7 PF13499.4 T370453_1 - 3e-21 75.5 4.9 8.9e-21 74.0 1.3 2.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.4 T370453_1 - 0.00028 20.1 0.0 0.0014 17.9 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 T370453_1 - 0.034 13.9 0.9 0.22 11.4 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.30 T370453_1 - 0.21 11.1 2.4 0.78 9.3 0.1 3.1 4 0 0 4 4 4 0 EF hand EF-hand_8 PF13833.4 T370453_1 - 0.37 10.5 2.5 1.3 8.8 0.2 3.1 4 1 0 4 4 4 0 EF-hand domain pair DUF3585 PF12130.6 T309398_1 - 8.2e-33 113.3 21.6 2e-32 112.1 21.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) CH PF00307.29 T309398_1 - 7.4e-19 67.8 0.0 1.8e-18 66.5 0.0 1.7 1 0 0 1 1 1 1 Calponin homology (CH) domain FAD_binding_3 PF01494.17 T309398_1 - 3.4e-06 26.4 0.0 5.9e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain LIM PF00412.20 T309398_1 - 1.1e-05 25.5 7.2 1.1e-05 25.5 7.2 2.0 2 0 0 2 2 1 1 LIM domain Pyr_redox_2 PF07992.12 T309398_1 - 3.9e-05 22.9 0.0 9.9e-05 21.6 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 T309398_1 - 0.00015 21.4 0.5 0.021 14.3 0.4 3.1 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 T309398_1 - 0.00035 19.6 2.6 0.00075 18.5 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.4 T309398_1 - 0.0012 18.0 0.0 0.0021 17.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 T309398_1 - 0.0026 16.4 0.0 0.0055 15.3 0.0 1.5 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_7 PF13241.4 T309398_1 - 0.0039 17.5 0.0 0.042 14.1 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding CAMSAP_CH PF11971.6 T309398_1 - 0.005 16.5 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain Pyr_redox PF00070.25 T309398_1 - 0.005 17.2 0.1 0.016 15.6 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 T309398_1 - 0.0058 16.7 0.1 0.016 15.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.10 T309398_1 - 0.0084 15.1 0.0 0.015 14.2 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FlhC PF05280.9 T309398_1 - 0.028 14.0 0.0 0.089 12.4 0.0 1.8 2 0 0 2 2 2 0 Flagellar transcriptional activator (FlhC) GIDA PF01134.20 T309398_1 - 0.058 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.5 T309398_1 - 0.12 11.6 0.2 0.19 10.9 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase ThiF PF00899.19 T309398_1 - 0.12 11.5 0.1 0.32 10.2 0.1 1.6 1 0 0 1 1 1 0 ThiF family Thi4 PF01946.15 T309398_1 - 0.21 10.7 0.0 0.38 9.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family MBT PF02820.16 T008942_1 - 1.2e-47 160.0 0.0 9.7e-25 86.6 0.0 2.5 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 T008942_1 - 1.7e-35 121.7 0.1 3.1e-35 120.9 0.1 1.4 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.28 T008942_1 - 6.1e-16 58.5 0.1 9.9e-16 57.8 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.1 T008942_1 - 7.5e-12 45.7 17.6 7.5e-12 45.7 17.6 2.6 2 0 0 2 2 2 1 RNA binding Region SAM_2 PF07647.15 T008942_1 - 8.8e-07 28.8 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 T008942_1 - 0.0058 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain AlbA_2 PF04326.12 T008942_2 - 1.8e-20 73.4 0.0 2.9e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 Putative DNA-binding domain EF-hand_7 PF13499.4 T277374_2 - 0.23 11.8 0.0 0.35 11.2 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain pair Fic PF02661.16 T085931_3 - 2.3e-27 95.6 0.0 4.1e-27 94.8 0.0 1.4 1 0 0 1 1 1 1 Fic/DOC family TPR_2 PF07719.15 T085931_3 - 0.017 15.0 0.3 0.099 12.7 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 T085931_3 - 0.045 13.9 0.3 0.26 11.5 0.3 2.3 1 1 0 1 1 1 0 Tetratricopeptide repeat BAR PF03114.16 T014438_1 - 1.9e-52 178.2 1.2 3.1e-52 177.5 1.2 1.3 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 T014438_1 - 1e-10 41.2 0.1 8e-10 38.3 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain BAR_2 PF10455.7 T014438_1 - 3.1e-09 36.2 0.7 4.4e-09 35.8 0.7 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.3 T014438_1 - 1.1e-07 31.7 0.3 1.7e-07 31.1 0.3 1.2 1 0 0 1 1 1 1 BAR domain of APPL family SH3_1 PF00018.26 T014438_1 - 3.3e-07 29.6 0.0 7.7e-07 28.5 0.0 1.7 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 T014438_1 - 9.7e-06 25.1 0.0 2.4e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain zf-MYND PF01753.16 T370244_2 - 3.5e-06 26.9 16.5 3.6e-06 26.8 12.7 3.1 2 0 0 2 2 2 1 MYND finger HNH_3 PF13392.4 T370244_2 - 4.3e-06 26.3 0.8 8.5e-06 25.4 0.8 1.4 1 0 0 1 1 1 1 HNH endonuclease WD40 PF00400.30 T370244_3 - 0.0035 18.0 3.3 0.69 10.8 0.1 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat C2 PF00168.28 T065165_3 - 1.7e-34 118.1 2.4 6e-20 71.3 0.5 3.2 3 0 0 3 3 3 2 C2 domain FYVE_2 PF02318.14 T065165_3 - 1.5e-06 28.3 0.8 4.3e-06 26.8 0.8 1.8 1 0 0 1 1 1 1 FYVE-type zinc finger MSC PF09402.8 T065165_3 - 0.093 12.1 2.2 0.18 11.2 0.3 2.3 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain Cystatin PF00031.19 T215302_3 - 7.8e-29 99.7 0.0 1.1e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 T215302_3 - 0.00025 21.2 0.0 0.00053 20.2 0.0 1.6 1 1 0 1 1 1 1 Aspartic acid proteinase inhibitor Cadherin PF00028.15 T160501_3 - 9.6e-55 182.9 0.4 1.9e-19 69.8 0.0 4.4 4 0 0 4 4 4 4 Cadherin domain Cadherin_C PF01049.15 T160501_3 - 8.4e-09 35.7 0.2 7.1e-08 32.7 0.0 2.1 2 0 0 2 2 2 1 Cadherin cytoplasmic region Cadherin_2 PF08266.10 T160501_3 - 0.057 13.1 0.0 12 5.7 0.0 3.2 3 0 0 3 3 3 0 Cadherin-like ABC_tran PF00005.25 T323672_3 - 3.4e-51 173.2 0.0 3.3e-28 98.8 0.3 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.5 T323672_3 - 1.2e-26 93.5 51.7 1.2e-16 60.7 18.5 3.4 3 1 1 4 4 4 2 ABC-2 family transporter protein AAA_21 PF13304.4 T323672_3 - 1e-15 58.2 4.3 3.9e-05 23.5 0.0 4.2 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 T323672_3 - 0.00021 21.7 0.9 0.013 15.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.4 T323672_3 - 0.0033 17.0 4.1 0.099 12.2 0.2 2.9 3 0 0 3 3 3 2 P-loop containing region of AAA domain DUF258 PF03193.14 T323672_3 - 0.025 14.4 1.1 0.46 10.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 GATA-N PF05349.10 T159662_3 - 3.7e-57 193.4 24.5 8.9e-57 192.1 24.5 1.7 1 0 0 1 1 1 1 GATA-type transcription activator, N-terminal GATA PF00320.25 T159662_3 - 2.1e-28 97.5 14.7 2.1e-14 52.7 4.5 2.8 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 T159662_3 - 1.2e-05 24.6 4.7 0.041 13.3 0.2 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Prim_Zn_Ribbon PF08273.10 T159662_3 - 1.9 8.8 6.8 0.46 10.8 0.8 2.7 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase eIF-5_eIF-2B PF01873.15 T159662_3 - 4.6 7.0 5.0 24 4.7 0.2 2.2 2 0 0 2 2 2 0 Domain found in IF2B/IF5 DUF4691 PF15762.3 T134816_1 - 4e-33 114.9 1.3 6.8e-33 114.2 1.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4691) DUF4691 PF15762.3 T134816_3 - 8.3e-45 153.0 13.5 7.7e-35 120.5 7.7 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4691) SAM_1 PF00536.28 T054240_1 - 8.2e-38 128.5 3.0 6.5e-17 61.6 0.0 3.8 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T054240_1 - 1.3e-37 127.5 0.9 1.3e-15 57.1 0.0 3.4 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) Reo_sigmaC PF04582.10 T054240_1 - 0.46 9.7 7.5 1.8 7.8 4.0 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein CALCOCO1 PF07888.9 T054240_1 - 0.74 8.2 26.1 1.2 7.5 26.1 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF16 PF01519.14 T054240_1 - 6.1 7.2 19.2 0.029 14.7 2.5 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 Ank_4 PF13637.4 T199028_2 - 1.7e-26 92.1 2.5 2.3e-06 27.9 0.0 5.9 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.5 T199028_2 - 2.2e-26 92.1 6.0 1.3e-09 38.4 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T199028_2 - 5.2e-26 90.2 2.4 1.6e-07 31.3 0.1 3.5 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 T199028_2 - 7e-24 83.1 5.6 6.9e-05 23.0 0.1 6.7 7 0 0 7 7 7 4 Ankyrin repeat CCDC144C PF14915.4 T199028_2 - 7.9e-18 64.5 0.5 1.2e-17 63.9 0.5 1.3 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region Ank_3 PF13606.4 T199028_2 - 3e-17 60.8 1.4 0.0056 17.0 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Actin PF00022.17 T199028_3 - 1.3e-141 471.7 0.0 3.2e-141 470.5 0.0 1.6 1 1 0 1 1 1 1 Actin CCDC144C PF14915.4 T199028_3 - 2.8e-14 52.8 5.0 2.8e-14 52.8 5.0 2.3 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region ANTH PF07651.14 T307359_2 - 5.5e-84 281.3 0.3 6.9e-84 281.0 0.3 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.18 T307359_2 - 1.7e-14 53.8 0.0 2.9e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 ENTH domain VHS PF00790.17 T307359_2 - 0.14 11.9 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 VHS domain RhlB PF12300.6 T307359_3 - 5.8 7.0 10.8 10 6.2 10.8 1.3 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB DUF4545 PF15078.4 T012761_1 - 1.4e-129 433.0 18.6 2.3e-97 326.8 7.7 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4545) Kelch_4 PF13418.4 T366461_1 - 1.7e-23 82.1 0.6 3.1e-07 30.1 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.4 T366461_1 - 6e-22 77.3 7.5 3.3e-08 33.5 0.1 4.7 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.4 T366461_1 - 3.7e-19 68.1 3.7 3.9e-05 23.4 0.0 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.23 T366461_1 - 5.1e-19 67.5 0.0 2.3e-06 26.9 0.0 3.9 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.4 T366461_1 - 1.3e-18 66.4 0.2 7.6e-05 22.7 0.0 3.9 2 1 1 3 3 3 3 Kelch motif Kelch_2 PF07646.13 T366461_1 - 4.4e-12 45.3 0.4 0.0026 17.5 0.0 4.0 3 1 0 3 3 3 3 Kelch motif Kelch_2 PF07646.13 T366461_2 - 3.7e-19 67.8 0.4 1.4e-17 62.8 0.1 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.4 T366461_2 - 7.5e-08 32.3 0.2 0.0055 16.8 0.0 3.5 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.4 T366461_2 - 1.9e-07 30.8 0.1 0.0036 17.1 0.0 2.6 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.4 T366461_2 - 3.1e-05 23.9 0.5 0.02 15.0 0.1 2.5 1 1 1 2 2 2 2 Kelch motif Kelch_1 PF01344.23 T366461_2 - 5.3e-05 22.6 0.0 0.0044 16.4 0.0 2.8 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.4 T366461_2 - 0.00041 20.1 4.1 0.15 11.9 0.1 3.3 4 0 0 4 4 4 2 Kelch motif ABM PF03992.14 T216438_1 - 4.6e-09 36.1 0.4 7.8e-09 35.4 0.4 1.4 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase E2F_CC-MB PF16421.3 T216438_2 - 7.8e-35 119.1 1.7 1.2e-34 118.5 1.7 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.18 T216438_2 - 5.4e-22 77.5 0.3 8.5e-22 76.8 0.3 1.3 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain Vps36-NZF-N PF16988.3 T216438_3 - 0.0018 17.5 0.1 0.0052 16.0 0.1 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain UAA PF08449.9 T296939_1 - 1.7e-12 47.1 0.8 2.3e-12 46.6 0.8 1.2 1 0 0 1 1 1 1 UAA transporter family RVT_1 PF00078.25 T019174_1 - 2e-08 33.9 0.0 4.3e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T019174_1 - 0.031 13.8 0.1 0.16 11.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T019174_2 - 8.5e-48 162.9 1.6 1.2e-47 162.5 1.6 1.1 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T019174_3 - 6.8e-20 71.1 2.4 1.2e-19 70.3 2.4 1.3 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T019174_3 - 1.6e-18 66.9 0.5 2.5e-18 66.3 0.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BTG PF07742.10 T083955_2 - 5.2e-42 142.2 0.0 7.7e-42 141.7 0.0 1.3 1 0 0 1 1 1 1 BTG family SPRR2 PF14820.4 T021235_2 - 6.1e-24 84.0 77.1 1.2e-23 83.1 77.1 1.5 1 0 0 1 1 1 1 Small proline-rich 2 SH2 PF00017.22 T193103_3 - 3.2e-08 33.4 0.0 5.1e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 SH2 domain RS4NT PF08071.10 T193103_3 - 0.0058 16.6 0.0 0.014 15.3 0.0 1.7 1 0 0 1 1 1 1 RS4NT (NUC023) domain VCX_VCY PF15231.4 T371066_1 - 1.7e-77 258.7 51.8 1e-69 233.5 31.8 2.2 1 1 1 2 2 2 2 Variable charge X/Y family DUF765 PF05570.9 T371066_1 - 2.2 8.4 5.3 8.2 6.6 5.3 2.0 1 0 0 1 1 1 0 Circovirus protein of unknown function (DUF765) LRR_9 PF14580.4 T063378_3 - 1.4e-11 44.1 0.0 3.2e-11 42.9 0.0 1.5 1 1 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.4 T063378_3 - 2.9e-06 26.8 1.5 2.9e-06 26.8 1.5 1.9 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.5 T063378_3 - 0.00092 19.4 5.1 0.0079 16.4 0.3 3.1 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) DUF1725 PF08333.9 T283120_3 - 0.00025 20.5 1.1 0.00057 19.3 1.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Astacin PF01400.22 T160590_1 - 2.7e-70 235.7 0.1 4e-70 235.2 0.1 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) MAM PF00629.21 T160590_1 - 1.6e-38 132.0 0.0 3.2e-38 131.0 0.0 1.5 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu EGF PF00008.25 T160590_1 - 0.0043 17.2 2.7 0.0043 17.2 2.7 2.7 3 0 0 3 3 3 1 EGF-like domain EGF_3 PF12947.5 T160590_1 - 3.1 8.0 7.6 8.6 6.5 7.6 1.8 1 0 0 1 1 1 0 EGF domain wnt PF00110.17 T032072_2 - 1.3e-119 399.1 19.0 1.6e-119 398.8 19.0 1.1 1 0 0 1 1 1 1 wnt family EF-hand_4 PF12763.5 T312419_2 - 1.1e-15 57.3 0.0 8.6e-12 44.8 0.0 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.30 T312419_2 - 0.0022 17.3 0.0 0.0052 16.1 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 T312419_2 - 0.0092 15.6 0.0 0.022 14.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.4 T312419_2 - 0.042 14.2 0.0 0.082 13.3 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.4 T312419_2 - 0.054 13.3 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain MCLC PF05934.9 T312419_2 - 3.5 6.1 4.2 5.6 5.4 4.2 1.2 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) HEAT PF02985.20 T312419_3 - 0.11 12.7 0.3 0.27 11.4 0.3 1.7 1 0 0 1 1 1 0 HEAT repeat Pecanex_C PF05041.13 T106749_3 - 2.5e-115 383.6 0.0 3.5e-115 383.1 0.0 1.2 1 0 0 1 1 1 1 Pecanex protein (C-terminus) UPF0258 PF06789.10 T120492_1 - 2e-65 219.7 0.0 3.5e-65 218.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0258) DUF4819 PF16090.3 T176214_2 - 3.8e-21 74.7 0.1 7.5e-21 73.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4819) HMG_box PF00505.17 T176214_2 - 8.2e-17 61.3 1.5 1.6e-16 60.3 1.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T176214_2 - 3.7e-07 30.5 0.4 8.9e-07 29.3 0.4 1.6 1 0 0 1 1 1 1 HMG-box domain THAP PF05485.10 T343065_3 - 6.5e-16 59.0 6.6 6.5e-16 59.0 6.6 2.1 2 0 0 2 2 1 1 THAP domain Cep57_CLD PF14073.4 T343065_3 - 0.00023 21.1 3.2 0.00037 20.4 3.2 1.2 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 Sec2p PF06428.9 T343065_3 - 0.0052 16.6 5.9 0.0084 15.9 5.9 1.3 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p MPS2 PF17060.3 T343065_3 - 0.037 13.1 3.2 0.061 12.5 3.2 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 ADIP PF11559.6 T343065_3 - 0.092 12.7 9.1 0.15 12.0 9.1 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4391 PF14335.4 T343065_3 - 0.12 11.9 1.9 0.18 11.3 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) PI3K_P85_iSH2 PF16454.3 T343065_3 - 0.16 11.4 9.6 0.27 10.7 9.6 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF16 PF01519.14 T343065_3 - 0.5 10.7 3.2 0.9 9.9 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 GrpE PF01025.17 T343065_3 - 0.68 9.5 4.8 1.1 8.8 4.8 1.2 1 0 0 1 1 1 0 GrpE TMF_DNA_bd PF12329.6 T343065_3 - 0.88 9.5 6.0 1.7 8.6 6.0 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Macoilin PF09726.7 T343065_3 - 1.9 6.8 5.6 2.7 6.3 5.6 1.1 1 0 0 1 1 1 0 Transmembrane protein ABC_tran_Xtn PF12848.5 T343065_3 - 2.1 8.3 7.6 3.9 7.4 7.6 1.3 1 0 0 1 1 1 0 ABC transporter IncA PF04156.12 T343065_3 - 3.5 7.2 5.1 5.4 6.6 5.1 1.2 1 0 0 1 1 1 0 IncA protein DivIC PF04977.13 T343065_3 - 3.6 7.3 6.3 6.5 6.5 6.3 1.3 1 0 0 1 1 1 0 Septum formation initiator RA PF00788.21 T315606_2 - 6e-46 154.9 0.0 7.3e-23 80.9 0.0 2.8 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain DIL PF01843.17 T315606_2 - 8.8e-31 106.2 2.0 1.2e-30 105.7 0.6 2.0 2 0 0 2 2 2 1 DIL domain PDZ PF00595.22 T315606_2 - 1.9e-16 60.1 0.5 1.9e-16 60.1 0.5 1.9 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) FHA PF00498.24 T315606_2 - 6.6e-07 29.5 0.0 1.4e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 FHA domain PDZ_2 PF13180.4 T315606_2 - 0.0022 18.2 0.4 0.006 16.8 0.4 1.7 1 0 0 1 1 1 1 PDZ domain Yop-YscD_cpl PF16697.3 T315606_2 - 0.0081 16.3 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain CHDCT2 PF08074.9 T141165_2 - 2.1e-83 278.6 2.9 6e-63 212.0 0.5 2.5 2 0 0 2 2 2 2 CHDCT2 (NUC038) domain DUF1086 PF06461.9 T141165_2 - 1.1e-61 206.6 0.0 2.9e-61 205.2 0.0 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.21 T141165_2 - 4.1e-61 206.5 0.0 8.8e-61 205.4 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain CHDNT PF08073.10 T141165_2 - 3.2e-26 90.8 0.4 7.3e-26 89.7 0.4 1.6 1 0 0 1 1 1 1 CHDNT (NUC034) domain DUF1087 PF06465.11 T141165_2 - 7.4e-25 86.7 6.6 7.4e-25 86.7 6.6 2.7 3 0 0 3 3 1 1 Domain of Unknown Function (DUF1087) Helicase_C PF00271.29 T141165_2 - 1.5e-21 76.7 0.0 2.7e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 T141165_2 - 3.9e-20 71.4 26.4 2e-10 40.2 7.3 2.6 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.22 T141165_2 - 4.6e-19 67.9 6.8 1e-13 50.8 2.5 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 T141165_2 - 2.3e-08 34.1 0.0 6.1e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 T141165_2 - 6e-08 32.1 0.0 1.5e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 HMG_box PF00505.17 T141165_2 - 0.0041 17.4 0.2 0.0041 17.4 0.2 2.2 2 0 0 2 2 1 1 HMG (high mobility group) box DEAD PF00270.27 T141165_2 - 0.0078 15.9 0.0 0.023 14.3 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase PHD_2 PF13831.4 T141165_2 - 0.07 12.5 11.5 0.32 10.4 3.1 2.7 2 0 0 2 2 2 0 PHD-finger AAA_22 PF13401.4 T141165_2 - 0.16 12.1 0.0 0.57 10.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain zf-PHD-like PF15446.4 T141165_2 - 3.6 7.1 15.1 1 8.8 0.5 3.0 1 1 2 3 3 3 0 PHD/FYVE-zinc-finger like domain EST1_DNA_bind PF10373.7 T026360_3 - 2.7e-55 187.7 5.2 2.7e-55 187.7 5.2 1.9 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.7 T026360_3 - 1.6e-27 96.6 0.3 7.5e-27 94.5 0.3 2.3 1 0 0 1 1 1 1 Telomerase activating protein Est1 zf-AD PF07776.13 T026360_3 - 0.011 15.9 0.5 0.041 14.0 0.5 2.1 1 1 0 1 1 1 0 Zinc-finger associated domain (zf-AD) TPR_2 PF07719.15 T026360_3 - 0.13 12.3 0.0 0.35 10.9 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.4 T026360_3 - 0.15 12.4 0.2 1.2 9.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2273 PF10031.7 T092671_3 - 0.76 9.7 5.4 1.2 9.1 5.4 1.3 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) PCI PF01399.25 T209614_2 - 5.1e-07 30.0 0.0 9.7e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 PCI domain Band_3_cyto PF07565.11 T209614_2 - 0.69 9.5 3.8 1.3 8.6 3.9 1.4 1 1 0 1 1 1 0 Band 3 cytoplasmic domain TTL PF03133.13 T000514_3 - 8.2e-26 90.7 0.0 1.2e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 T000514_3 - 0.00055 19.1 0.0 0.00088 18.5 0.0 1.2 1 0 0 1 1 1 1 YheC/D like ATP-grasp PPARgamma_N PF12577.6 T238123_3 - 1.9e-32 111.6 0.9 6.8e-32 109.8 1.3 1.8 2 0 0 2 2 2 1 PPAR gamma N-terminal region zf-C4 PF00105.16 T238123_3 - 1.9e-27 95.3 15.0 3.7e-27 94.5 15.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 T238123_3 - 1.9e-16 60.2 0.1 4.6e-16 58.9 0.1 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 T238123_3 - 0.026 13.5 3.1 0.042 12.8 3.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A ISK_Channel PF02060.13 T225482_3 - 1.7e-61 205.2 0.0 2.5e-61 204.7 0.0 1.2 1 0 0 1 1 1 1 Slow voltage-gated potassium channel Pkinase PF00069.23 T241110_1 - 5.9e-75 251.9 0.0 8.1e-75 251.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T241110_1 - 2.9e-41 141.3 0.0 4.2e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T241110_1 - 2.3e-09 36.8 0.0 7.5e-09 35.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 T241110_1 - 0.04 13.1 0.0 0.066 12.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Fibrinogen_C PF00147.16 T368574_1 - 3.7e-43 147.8 0.1 5.5e-43 147.2 0.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Collagen PF01391.16 T368574_1 - 0.0044 16.6 8.9 0.0044 16.6 8.9 1.9 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) RRM_1 PF00076.20 T106570_3 - 3.5e-24 84.3 0.6 1.7e-15 56.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 T106570_3 - 0.00019 21.3 0.0 0.066 13.1 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.4 T106570_3 - 0.00022 21.0 0.0 0.0016 18.3 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF4551 PF15087.4 T106570_3 - 2.6 6.6 13.2 4.5 5.9 13.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) TBD PF12845.5 T149428_2 - 1.2e-17 63.4 0.0 3.9e-17 61.7 0.0 2.0 1 0 0 1 1 1 1 TBD domain IncA PF04156.12 T149428_2 - 0.0063 16.2 4.9 0.0063 16.2 4.9 2.4 2 0 0 2 2 2 1 IncA protein CT_C_D PF02682.14 T149428_2 - 0.41 10.2 2.5 0.51 9.9 0.4 1.9 2 0 0 2 2 2 0 Carboxyltransferase domain, subdomain C and D Seryl_tRNA_N PF02403.20 T149428_2 - 0.63 10.2 13.9 0.074 13.2 2.5 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Mod_r PF07200.11 T149428_2 - 0.75 9.8 16.9 0.018 15.0 6.0 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Prominin PF05478.9 T149428_2 - 2.6 5.8 4.0 4.1 5.1 4.0 1.2 1 0 0 1 1 1 0 Prominin DUF3584 PF12128.6 T149428_2 - 5 4.4 13.0 0.42 7.9 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Y_phosphatase PF00102.25 T083036_2 - 3e-76 255.9 0.0 3.8e-76 255.6 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 T083036_2 - 0.00049 20.0 0.0 0.00069 19.5 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 T083036_2 - 0.028 14.1 0.0 0.05 13.3 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 T083036_2 - 0.037 14.0 0.0 0.07 13.1 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate PLAT PF01477.21 T139997_2 - 1.5e-10 41.5 0.0 3e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain Lipoxygenase PF00305.17 T139997_3 - 9e-56 189.5 0.0 3.1e-55 187.7 0.0 1.7 1 1 0 1 1 1 1 Lipoxygenase zf-CW PF07496.13 T225734_1 - 1.4e-16 60.1 6.1 9.4e-16 57.5 6.1 2.6 1 0 0 1 1 1 1 CW-type Zinc Finger HATPase_c_3 PF13589.4 T225734_1 - 8.8e-16 57.8 0.0 1.6e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 T225734_1 - 4.6e-05 23.8 0.0 9.1e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2353 PF09789.7 T225734_1 - 0.22 10.8 21.4 0.01 15.1 7.3 2.8 2 1 1 3 3 3 0 Uncharacterized coiled-coil protein (DUF2353) SOGA PF11365.6 T225734_1 - 1.8 9.6 17.3 2.2 9.3 2.5 2.5 2 0 0 2 2 2 0 Protein SOGA bZIP_1 PF00170.19 T225734_1 - 3.9 7.5 10.7 1.6 8.7 3.3 3.3 3 0 0 3 3 3 0 bZIP transcription factor Dopey_N PF04118.12 T225734_2 - 5.5e-98 327.7 3.0 9.4e-98 327.0 1.3 2.3 2 0 0 2 2 2 1 Dopey, N-terminal PS_Dcarbxylase PF02666.13 T232384_3 - 1.2e-67 227.2 0.0 1.6e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Arm PF00514.21 T147572_2 - 2.7e-40 135.1 19.8 3.2e-09 36.4 0.1 10.6 12 0 0 12 12 12 6 Armadillo/beta-catenin-like repeat HEAT PF02985.20 T147572_2 - 1.7e-07 30.7 2.0 0.27 11.4 0.0 5.7 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.5 T147572_2 - 3.1e-05 23.9 4.5 0.0092 15.9 0.2 4.1 4 1 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.12 T147572_2 - 3.5e-05 23.1 1.2 0.044 12.9 0.0 3.5 1 1 1 3 3 3 2 V-ATPase subunit H Atx10homo_assoc PF09759.7 T147572_2 - 5.4e-05 23.1 2.0 0.0052 16.7 0.1 3.9 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Adaptin_N PF01602.18 T147572_2 - 0.00016 20.2 1.3 0.00016 20.2 1.3 2.7 2 1 0 2 2 2 1 Adaptin N terminal region HEAT_2 PF13646.4 T147572_2 - 0.00021 21.5 14.4 0.00084 19.5 1.0 5.6 4 3 2 6 6 6 1 HEAT repeats HEAT_EZ PF13513.4 T147572_2 - 0.0011 19.3 11.1 4.8 7.6 0.1 7.1 6 2 2 8 8 8 1 HEAT-like repeat DUF3361 PF11841.6 T147572_2 - 0.002 17.9 4.2 0.34 10.7 0.4 4.4 3 2 2 5 5 5 1 Domain of unknown function (DUF3361) KAP PF05804.10 T147572_2 - 0.02 12.9 1.5 1.7 6.5 0.1 3.1 2 1 2 4 4 4 0 Kinesin-associated protein (KAP) RasGEF_N_2 PF14663.4 T147572_2 - 0.022 14.9 2.7 53 4.1 0.0 4.3 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Arm_2 PF04826.11 T147572_2 - 0.083 12.2 6.2 1.1 8.5 0.3 4.4 3 2 1 5 5 5 0 Armadillo-like PUL PF08324.9 T147572_2 - 0.29 10.3 5.0 0.17 11.1 0.3 2.5 2 1 0 2 2 2 0 PUL domain NHL PF01436.19 T048903_2 - 3e-27 93.1 1.0 8.9e-06 25.4 0.0 6.3 6 0 0 6 6 6 4 NHL repeat Thioredoxin_8 PF13905.4 T048903_2 - 2.2e-10 40.6 0.0 4.1e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like SGL PF08450.10 T048903_2 - 5e-05 22.9 0.1 0.016 14.7 0.0 2.7 2 1 0 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.18 T048903_2 - 0.0021 18.1 0.0 2.7 8.1 0.0 3.3 3 0 0 3 3 3 2 Arylesterase CCDC92 PF14916.4 T199084_1 - 2.9e-13 49.2 11.6 4.8e-11 42.1 8.4 2.3 2 0 0 2 2 2 2 Coiled-coil domain of unknown function CCDC74_C PF14917.4 T199084_3 - 4.3e-38 130.4 6.2 4.3e-38 130.4 6.2 1.6 2 0 0 2 2 2 1 Coiled coil protein 74, C terminal RGS PF00615.17 T049514_3 - 3.5e-32 111.0 6.9 6.4e-32 110.2 6.9 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.9 T049514_3 - 0.0069 16.0 0.3 0.01 15.4 0.3 1.3 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain UPF0688 PF15772.3 T001749_1 - 1e-104 349.8 20.2 3.7e-93 312.0 7.1 2.1 2 0 0 2 2 2 2 UPF0688 family Synaptobrevin PF00957.19 T193149_1 - 1.7e-24 85.3 1.6 2.8e-24 84.6 1.6 1.2 1 0 0 1 1 1 1 Synaptobrevin Synaptobrevin PF00957.19 T193149_3 - 2.8e-30 103.8 1.7 4.4e-30 103.2 1.7 1.3 1 0 0 1 1 1 1 Synaptobrevin zf-RING_2 PF13639.4 T193149_3 - 9.5e-13 48.1 8.4 9.5e-13 48.1 8.4 3.0 3 1 1 4 4 3 1 Ring finger domain zf-C3HC4_2 PF13923.4 T193149_3 - 1.6e-09 37.3 8.5 4e-09 36.0 8.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 T193149_3 - 8.3e-09 35.5 4.5 2.5e-08 33.9 4.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 T193149_3 - 6.5e-07 28.8 6.9 1.7e-06 27.5 6.9 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.23 T193149_3 - 1.3e-06 28.1 8.1 1.3e-06 28.1 8.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T193149_3 - 7.7e-06 25.6 5.0 1.7e-05 24.5 5.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 T193149_3 - 2.5e-05 24.0 6.0 2.5e-05 24.0 6.0 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 T193149_3 - 7.6e-05 22.6 0.8 0.00021 21.1 0.8 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.4 T193149_3 - 0.00012 21.7 3.3 0.00028 20.5 3.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 T193149_3 - 0.00032 20.4 3.9 0.00032 20.4 3.9 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-Nse PF11789.6 T193149_3 - 0.0022 17.6 3.8 0.0048 16.6 3.8 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Rad50_zn_hook PF04423.12 T193149_3 - 0.11 12.2 4.4 5.6 6.8 0.1 2.7 3 0 0 3 3 3 0 Rad50 zinc hook motif DUF912 PF06024.10 T193149_3 - 0.19 11.9 0.2 0.42 10.8 0.2 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Zn_ribbon_17 PF17120.3 T193149_3 - 0.75 9.3 11.2 0.016 14.7 3.8 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-P11 PF03854.12 T193149_3 - 1.1 8.9 5.7 4.4 6.9 5.7 2.1 1 0 0 1 1 1 0 P-11 zinc finger Ferlin_C PF16165.3 T193149_3 - 3.1 7.6 6.8 0.087 12.6 0.3 1.7 2 0 0 2 2 1 0 Ferlin C-terminus Peptidase_C48 PF02902.17 T306820_2 - 6.3e-34 117.6 3.1 2.4e-20 73.2 1.3 2.3 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain FAD_binding_4 PF01565.21 T211849_2 - 2.6e-10 40.1 0.0 5.7e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Gal-3-0_sulfotr PF06990.9 T211849_3 - 3.5e-189 628.7 2.0 4.5e-189 628.3 2.0 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase FAD-oxidase_C PF02913.17 T211849_3 - 4.3e-59 200.0 0.0 5.7e-59 199.6 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.21 T211849_3 - 1.2e-13 50.9 0.2 2.7e-13 49.7 0.2 1.6 1 0 0 1 1 1 1 FAD binding domain Sulfotransfer_2 PF03567.12 T211849_3 - 0.056 13.2 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 Sulfotransferase family Neur_chan_LBD PF02931.21 T307894_2 - 1.1e-50 172.0 0.4 1.7e-50 171.3 0.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 T307894_2 - 9.7e-36 123.9 6.2 3.3e-30 105.8 3.6 2.3 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region WD40 PF00400.30 T274901_1 - 2.7e-17 62.7 38.1 0.00027 21.5 0.1 9.2 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T274901_1 - 2.1e-14 53.5 0.8 0.0004 20.5 0.0 5.4 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain DUF2065 PF09838.7 T274901_1 - 0.17 11.8 0.2 0.39 10.6 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2065) Nup160 PF11715.6 T274901_1 - 0.45 8.9 5.2 0.68 8.3 0.0 3.3 4 0 0 4 4 4 0 Nucleoporin Nup120/160 PHR PF08005.10 T096471_3 - 2.5e-84 281.3 0.0 1.1e-40 139.6 0.0 2.7 2 0 0 2 2 2 2 PHR domain RCC1 PF00415.16 T096471_3 - 2e-21 76.2 25.0 3.1e-12 46.8 1.6 7.1 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 T096471_3 - 1.5e-20 72.3 13.7 9.5e-08 31.5 0.1 5.3 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat SH3_3 PF08239.9 T096471_3 - 2.9e-15 56.1 0.4 3.2e-07 30.4 0.0 3.5 3 0 0 3 3 3 2 Bacterial SH3 domain zf-RING_2 PF13639.4 T096471_3 - 1.8e-07 31.1 6.9 1.8e-07 31.1 6.9 4.9 5 1 0 5 5 5 1 Ring finger domain Filamin PF00630.17 T096471_3 - 6.2e-06 26.8 0.0 1.8e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 Filamin/ABP280 repeat ANAPC10 PF03256.14 T096471_3 - 2.2e-05 24.1 0.1 5.1e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) zf-RING_11 PF17123.3 T096471_3 - 0.0048 16.5 8.4 0.043 13.4 8.4 2.9 1 0 0 1 1 1 1 RING-like zinc finger PX PF00787.22 T317461_2 - 1.4e-20 73.2 1.5 2.6e-20 72.4 1.5 1.4 1 0 0 1 1 1 1 PX domain Perilipin PF03036.14 T317461_2 - 0.25 10.2 4.0 0.43 9.5 4.0 1.3 1 0 0 1 1 1 0 Perilipin family RMI2 PF16100.3 T127336_1 - 3.5e-20 72.0 0.1 5.7e-20 71.3 0.1 1.3 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 HLH PF00010.24 T121915_3 - 1.2e-12 47.5 0.4 1.9e-12 46.8 0.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain AJAP1_PANP_C PF15298.4 T072645_3 - 2.7e-07 30.9 0.0 5.5e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 AJAP1/PANP C-terminus SAM_1 PF00536.28 T083087_2 - 3.6e-26 91.2 0.5 7.6e-13 48.6 0.2 3.6 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T083087_2 - 2.4e-21 75.5 0.5 1.3e-07 31.5 0.1 3.6 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) IL17_R_N PF15037.4 T237783_1 - 3.3e-139 464.1 3.0 5.7e-138 460.1 3.0 2.1 1 1 0 1 1 1 1 Interleukin-17 receptor extracellular region SEFIR PF08357.9 T237783_1 - 2.5e-21 76.4 0.0 5.8e-20 72.0 0.0 2.3 1 1 0 1 1 1 1 SEFIR domain DUF3456 PF11938.6 T237783_1 - 5e-09 36.7 1.2 0.00023 21.6 0.0 2.3 1 1 1 2 2 2 2 TLR4 regulator and MIR-interacting MSAP EGF_CA PF07645.13 T237783_1 - 2.1e-07 30.9 9.6 2.1e-07 30.9 9.6 6.3 5 1 0 5 5 5 2 Calcium-binding EGF domain IL17_R_N PF15037.4 T237783_3 - 4.3e-143 476.9 19.1 1.8e-141 471.6 19.1 2.7 1 1 0 1 1 1 1 Interleukin-17 receptor extracellular region SEFIR PF08357.9 T237783_3 - 6.4e-38 130.2 0.0 8.9e-38 129.8 0.0 1.2 1 0 0 1 1 1 1 SEFIR domain DDE_1 PF03184.17 T024410_3 - 2.2e-43 147.7 0.0 3.1e-43 147.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease BrkDBD PF09607.8 T024410_3 - 4.8e-25 87.0 0.1 8.6e-25 86.2 0.1 1.4 1 0 0 1 1 1 1 Brinker DNA-binding domain HTH_Tnp_Tc5 PF03221.14 T024410_3 - 9.8e-13 47.8 0.0 2.1e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Fn3_assoc PF13287.4 T214500_3 - 9.1e-17 60.8 0.2 1.6e-16 60.0 0.2 1.4 1 0 0 1 1 1 1 Fn3 associated DZR PF12773.5 T214500_3 - 1.6e-15 56.7 38.3 2.8e-08 33.5 9.9 3.7 3 0 0 3 3 3 3 Double zinc ribbon CHB_HEX_C_1 PF13290.4 T214500_3 - 4.3e-14 52.1 0.1 7.2e-14 51.4 0.1 1.3 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain Ank_2 PF12796.5 T214500_3 - 1.7e-05 25.2 0.0 5.5e-05 23.6 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) zinc_ribbon_2 PF13240.4 T214500_3 - 0.0018 17.8 3.7 0.0018 17.8 3.7 5.3 5 1 0 5 5 5 2 zinc-ribbon domain zf-C4H2 PF10146.7 T214500_3 - 0.005 17.0 1.5 0.014 15.6 1.5 1.7 1 0 0 1 1 1 1 Zinc finger-containing protein Ank_4 PF13637.4 T214500_3 - 0.014 15.8 0.0 0.35 11.4 0.0 2.7 1 1 2 3 3 3 0 Ankyrin repeats (many copies) zf-RanBP PF00641.16 T214500_3 - 0.026 13.7 0.3 0.026 13.7 0.3 4.4 4 0 0 4 4 4 0 Zn-finger in Ran binding protein and others zinc-ribbon_6 PF10005.7 T214500_3 - 3.9 8.1 13.6 16 6.1 0.1 4.0 3 1 0 3 3 3 0 zinc-ribbon domain DUF3704 PF12488.6 T115390_1 - 3e-07 29.8 4.5 7.5e-07 28.6 4.5 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3704) zf-UBR PF02207.18 T115390_3 - 2.5e-21 75.5 11.7 2.5e-21 75.5 11.7 3.6 5 0 0 5 5 5 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.15 T115390_3 - 3.4e-21 74.7 0.6 6.7e-21 73.7 0.6 1.5 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS ATPase_2 PF01637.16 T115390_3 - 0.11 12.3 0.1 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea BCS1_N PF08740.9 T207779_1 - 2.4e-28 99.3 0.9 3.5e-28 98.7 0.9 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.27 T207779_3 - 1.1e-17 64.6 0.0 1.9e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.9 T207779_3 - 1.3e-06 28.4 0.0 1.8e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA_16 PF13191.4 T207779_3 - 0.0012 19.1 0.0 0.0025 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.20 T207779_3 - 0.0018 18.5 0.0 0.0048 17.1 0.0 1.7 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.4 T207779_3 - 0.0099 15.3 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.11 T207779_3 - 0.02 14.0 0.0 0.029 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.25 T207779_3 - 0.035 14.5 0.0 0.056 13.8 0.0 1.2 1 0 0 1 1 1 0 ABC transporter Polyoma_lg_T_C PF06431.9 T207779_3 - 0.047 12.4 0.0 0.12 11.1 0.0 1.5 2 0 0 2 2 2 0 Polyomavirus large T antigen C-terminus AAA_5 PF07728.12 T207779_3 - 0.066 13.1 0.0 0.15 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.4 T207779_3 - 0.088 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_11 PF13086.4 T207779_3 - 0.16 11.5 0.0 0.25 10.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.13 T207779_3 - 0.22 10.3 0.0 0.33 9.6 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein PDEase_I PF00233.17 T321279_3 - 9.3e-81 270.9 4.3 1.4e-80 270.3 4.3 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.10 T321279_3 - 8e-31 105.5 0.1 1.6e-30 104.6 0.1 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal PHD PF00628.27 T336187_3 - 6.9e-39 131.4 132.8 1.3e-09 37.7 6.8 10.2 5 2 4 9 9 9 6 PHD-finger FYRC PF05965.12 T336187_3 - 2.7e-23 81.8 0.0 9.4e-23 80.0 0.0 2.0 1 0 0 1 1 1 1 F/Y rich C-terminus FYRN PF05964.12 T336187_3 - 2e-20 72.3 0.1 4.2e-20 71.2 0.1 1.6 1 0 0 1 1 1 1 F/Y-rich N-terminus SET PF00856.26 T336187_3 - 5e-18 65.9 0.2 5e-18 65.9 0.2 3.7 3 0 0 3 3 3 1 SET domain zf-HC5HC2H PF13771.4 T336187_3 - 2.6e-14 53.1 25.9 1.5e-09 37.8 9.3 9.6 4 2 4 8 8 8 3 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 T336187_3 - 6.4e-14 51.9 26.9 2.9e-10 40.1 8.9 8.4 3 2 4 7 7 7 3 PHD-zinc-finger like domain HMG_box PF00505.17 T336187_3 - 0.00012 22.3 0.1 0.00012 22.3 0.1 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box Steroid_dh PF02544.14 T265518_2 - 3.2e-07 30.3 2.3 3.2e-07 30.3 2.3 1.8 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase SPATIAL PF15256.4 T043502_1 - 9.1e-71 238.2 0.1 9.1e-71 238.2 0.1 1.6 2 0 0 2 2 2 1 SPATIAL Sushi PF00084.18 T152794_1 - 2.1e-42 143.4 26.7 9.2e-12 45.3 0.7 5.2 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) Sushi_2 PF09014.8 T152794_1 - 1.4e-35 121.0 5.5 3.3e-35 119.8 5.5 1.7 1 0 0 1 1 1 1 Beta-2-glycoprotein-1 fifth domain cEGF PF12662.5 T152794_1 - 0.07 12.9 9.0 14 5.6 0.2 4.4 3 0 0 3 3 3 0 Complement Clr-like EGF-like HRM PF02793.20 T152794_1 - 0.36 11.0 8.6 5.2 7.3 0.1 3.8 3 0 0 3 3 3 0 Hormone receptor domain zinc_ribbon_12 PF11331.6 T152794_2 - 1.8 8.3 7.7 6.9 6.4 0.4 3.2 3 0 0 3 3 3 0 Probable zinc-ribbon domain zf-SAP30 PF13866.4 T291834_2 - 3.1e-36 123.1 3.4 3.1e-36 123.1 3.4 2.2 2 0 0 2 2 2 1 SAP30 zinc-finger SAP30_Sin3_bdg PF13867.4 T291834_3 - 1.1e-23 83.1 0.9 1.8e-23 82.5 0.9 1.4 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 SBF_like PF13593.4 T272599_1 - 9.2e-77 258.3 21.3 1.3e-76 257.8 21.3 1.2 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.14 T272599_1 - 8.2e-15 54.9 11.6 1.9e-14 53.7 11.6 1.6 1 0 0 1 1 1 1 Sodium Bile acid symporter family TPR_1 PF00515.26 T067488_1 - 4.5e-08 32.4 4.4 0.0013 18.3 0.7 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.15 T067488_1 - 7.8e-06 25.5 2.0 0.0014 18.5 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 T067488_1 - 0.00058 19.7 3.5 0.008 16.2 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 T067488_1 - 0.074 13.0 0.9 5.2 7.1 0.1 2.4 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Yae1_N PF09811.7 T067488_3 - 1.4 8.5 5.5 2.8 7.6 5.5 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Laminin_G_2 PF02210.22 T107963_2 - 3.4e-22 79.2 0.1 6.8e-22 78.3 0.1 1.5 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 T107963_2 - 8.7e-10 38.8 0.3 2.4e-09 37.4 0.0 1.8 2 0 0 2 2 2 1 Laminin G domain Syndecan PF01034.18 T107963_2 - 2.2e-07 30.5 0.0 5e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Syndecan domain DUF202 PF02656.13 T107963_2 - 0.065 13.6 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Peptidase_S49_N PF08496.8 T107963_2 - 0.85 9.6 9.5 3.6 7.5 0.1 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Homeobox PF00046.27 T192155_3 - 1.1e-18 66.6 7.0 2.1e-18 65.8 7.0 1.5 1 0 0 1 1 1 1 Homeobox domain zf-C2HC_2 PF13913.4 T107479_1 - 0.025 14.3 5.5 0.067 13.0 5.5 1.7 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Auts2 PF15336.4 T326049_1 - 1.2e-107 358.9 15.2 1.2e-107 358.9 15.2 4.6 4 1 1 5 5 5 1 Autism susceptibility gene 2 protein DUF2798 PF11391.6 T331206_2 - 0.15 12.0 1.9 0.74 9.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2798) Peptidase_S26 PF10502.7 T331206_3 - 0.002 17.8 0.0 0.047 13.3 0.0 2.1 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.21 T331206_3 - 0.075 12.9 0.2 0.13 12.1 0.2 1.3 1 0 0 1 1 1 0 Peptidase S24-like SapB_2 PF03489.15 T193213_2 - 0.00067 19.6 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 Saposin-like type B, region 2 WD40 PF00400.30 T063567_2 - 3.1e-15 56.2 17.9 0.15 12.9 0.0 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat ATG16 PF08614.9 T063567_3 - 5.3e-35 121.3 18.2 5.6e-18 65.7 17.1 2.2 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) IncA PF04156.12 T063567_3 - 4.4 6.9 11.9 7.6 6.1 11.9 1.2 1 0 0 1 1 1 0 IncA protein Macoilin PF09726.7 T063567_3 - 5.8 5.2 7.7 8.5 4.7 7.7 1.1 1 0 0 1 1 1 0 Transmembrane protein Sulfotransfer_1 PF00685.25 T234883_1 - 0.016 14.6 0.0 0.022 14.1 0.0 1.1 1 0 0 1 1 1 0 Sulfotransferase domain Sulfotransfer_1 PF00685.25 T234883_3 - 1.3e-50 172.3 0.0 1.8e-50 171.8 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 T234883_3 - 4.7e-09 36.8 0.1 2.6e-07 31.1 0.2 2.1 2 0 0 2 2 2 1 Sulfotransferase family FdsD PF11390.6 T234883_3 - 0.0067 16.6 0.1 4.1 7.7 0.1 2.4 2 0 0 2 2 2 2 NADH-dependant formate dehydrogenase delta subunit FdsD SCAN PF02023.15 T140239_2 - 5.1e-41 138.3 3.0 1e-40 137.3 3.0 1.5 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 T140239_2 - 4.9e-34 115.1 33.8 2.8e-08 33.7 0.4 6.8 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 T140239_2 - 5.4e-25 86.3 33.6 8.7e-07 28.9 1.0 5.9 6 0 0 6 6 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T140239_2 - 1.6e-12 47.0 30.4 0.0045 17.6 0.7 5.8 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T140239_2 - 1.6e-09 37.4 24.3 0.17 11.7 0.7 5.8 5 0 0 5 5 5 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T140239_2 - 0.00011 22.1 19.4 0.017 15.1 3.1 3.8 2 1 1 3 3 3 2 Zinc ribbon domain XPA_N PF01286.16 T140239_2 - 0.0023 17.8 21.8 0.24 11.4 0.4 5.4 5 0 0 5 5 5 2 XPA protein N-terminal zf-trcl PF13451.4 T140239_2 - 0.013 15.2 16.4 9.9 6.0 0.1 5.4 5 0 0 5 5 5 0 Probable zinc-ribbon domain DZR PF12773.5 T140239_2 - 0.1 12.5 15.1 0.83 9.6 4.9 3.2 1 1 1 2 2 2 0 Double zinc ribbon HypA PF01155.17 T140239_2 - 0.18 11.7 11.6 4.7 7.1 1.0 3.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 T140239_2 - 0.2 12.3 15.1 0.54 10.9 1.5 3.2 1 1 2 3 3 3 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 T140239_2 - 0.3 11.3 16.8 2.9 8.2 0.1 5.2 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding YhfH PF14149.4 T140239_2 - 1.2 9.0 17.0 26 4.8 0.1 5.4 5 0 0 5 5 5 0 YhfH-like protein DUF3268 PF11672.6 T140239_2 - 1.3 9.3 11.9 0.54 10.5 1.3 2.8 1 1 1 3 3 3 0 zinc-finger-containing domain zf-C2H2_11 PF16622.3 T140239_2 - 1.3 8.7 18.1 0.19 11.4 0.3 5.0 5 0 0 5 5 5 0 zinc-finger C2H2-type DUF2321 PF10083.7 T140239_2 - 2.2 7.8 11.8 1 8.8 1.4 3.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) ADK_lid PF05191.12 T140239_2 - 2.3 8.2 12.1 4.9 7.1 1.7 4.0 3 1 2 5 5 4 0 Adenylate kinase, active site lid zf-LYAR PF08790.9 T140239_2 - 2.4 8.0 14.9 0.85 9.5 0.3 4.4 5 0 0 5 5 4 0 LYAR-type C2HC zinc finger CpXC PF14353.4 T140239_2 - 5.2 7.0 11.5 8.8 6.3 0.0 4.5 2 1 2 4 4 4 0 CpXC protein LIM PF00412.20 T140239_2 - 8.7 6.5 15.5 6.7 6.9 1.2 4.2 2 1 1 4 4 3 0 LIM domain TFIIS_C PF01096.16 T140239_2 - 8.8 6.1 19.1 14 5.5 0.4 5.4 5 0 0 5 5 5 0 Transcription factor S-II (TFIIS) zf-AN1 PF01428.14 T140239_2 - 9.5 6.4 22.9 21 5.3 0.2 5.4 4 1 1 5 5 5 0 AN1-like Zinc finger AMP-binding PF00501.26 T228392_1 - 1.8e-77 260.6 0.7 6.7e-50 169.8 0.4 2.2 2 0 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.9 T228392_1 - 8.1e-35 119.9 1.0 1.4e-34 119.1 1.0 1.4 1 0 0 1 1 1 1 DMAP1-binding Domain GvpG PF05120.10 T228392_1 - 0.014 15.2 0.1 0.027 14.3 0.1 1.3 1 0 0 1 1 1 0 Gas vesicle protein G PACT_coil_coil PF10495.7 T228392_3 - 7.5e-24 84.0 0.2 7.5e-24 84.0 0.2 4.5 4 0 0 4 4 4 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein AMP-binding PF00501.26 T228392_3 - 3.8e-09 35.5 0.7 5.7e-09 34.9 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme wnt PF00110.17 T149184_3 - 1.1e-99 333.8 16.8 1.5e-99 333.2 16.8 1.2 1 0 0 1 1 1 1 wnt family Pkinase_Tyr PF07714.15 T170494_2 - 1.4e-100 335.8 0.0 1.9e-51 174.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.23 T170494_2 - 9.6e-50 169.2 0.0 1.8e-30 106.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain SH2 PF00017.22 T170494_2 - 0.057 13.3 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 SH2 domain APH PF01636.21 T170494_2 - 0.058 13.2 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 T170494_2 - 0.063 12.5 0.0 0.51 9.5 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.15 T170494_3 - 1.3e-23 83.5 0.0 1.9e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T170494_3 - 6.6e-08 32.1 0.0 9.7e-08 31.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain CFC PF09443.8 T241668_2 - 3.1e-15 55.6 16.4 3.8e-15 55.3 10.2 3.1 2 0 0 2 2 2 2 Cripto_Frl-1_Cryptic (CFC) Tet_JBP PF12851.5 T043156_3 - 1.2e-139 465.2 0.0 1.2e-139 465.2 0.0 2.1 2 1 0 2 2 2 1 Oxygenase domain of the 2OGFeDO superfamily MHC_I_3 PF16497.3 T022997_2 - 2e-93 311.3 4.4 3e-93 310.7 4.4 1.3 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 T022997_2 - 2.8e-10 40.4 0.0 5.8e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain NOB1_Zn_bind PF08772.9 T156143_3 - 0.0087 16.1 0.3 0.026 14.5 0.3 1.7 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like DZR PF12773.5 T156143_3 - 0.027 14.3 7.1 0.038 13.9 4.5 2.7 2 1 0 2 2 2 0 Double zinc ribbon Nudix_N_2 PF14803.4 T156143_3 - 0.084 12.7 2.1 0.45 10.3 0.1 3.0 2 0 0 2 2 2 0 Nudix N-terminal Roc PF08477.11 T330120_2 - 1.1e-05 25.5 0.0 1.9e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 T330120_2 - 8.5e-05 22.1 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Arf PF00025.19 T330120_2 - 0.14 11.5 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family KRAB PF01352.25 T040201_1 - 2.4e-23 81.4 0.2 4.3e-23 80.6 0.2 1.4 1 0 0 1 1 1 1 KRAB box DUF4187 PF13821.4 T040201_1 - 7.6 6.3 9.2 9 6.0 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4187) zf-C2H2_11 PF16622.3 T020828_2 - 4.1e-17 61.5 9.9 1.9e-14 53.0 0.4 8.2 10 0 0 10 10 10 4 zinc-finger C2H2-type zf-C2H2_4 PF13894.4 T020828_2 - 1.7e-13 50.0 105.2 0.026 15.2 2.2 15.2 15 0 0 15 15 15 11 C2H2-type zinc finger zf-C2H2 PF00096.24 T020828_2 - 5.3e-12 45.4 100.4 0.013 15.7 1.9 14.6 14 0 0 14 14 14 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T020828_2 - 0.00021 21.5 64.8 0.046 14.1 0.5 12.4 12 0 0 12 12 12 4 Zinc-finger double domain zf-met PF12874.5 T020828_2 - 0.0064 16.7 48.7 0.016 15.4 1.3 9.6 11 0 0 11 11 11 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T020828_2 - 1.3 9.3 29.3 0.3 11.3 0.1 8.4 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding V-set PF07686.15 T247973_2 - 4.4e-11 42.8 2.8 5.5e-05 23.2 0.5 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 T247973_2 - 6.4e-07 29.8 6.4 0.0059 17.1 0.4 4.3 3 1 1 4 4 4 2 Immunoglobulin domain ig PF00047.23 T247973_2 - 0.00029 20.8 3.9 0.11 12.5 0.4 3.2 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.10 T247973_2 - 0.00083 19.3 0.0 0.0088 16.0 0.0 2.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain PH PF00169.27 T028596_3 - 4.3e-20 72.0 0.1 9.1e-20 71.0 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 T028596_3 - 7.7e-09 35.8 0.1 1.3e-08 35.0 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 T028596_3 - 0.0018 18.4 0.0 0.0051 16.9 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain Tropomyosin_1 PF12718.5 T028596_3 - 0.49 10.4 8.7 1.4 8.9 8.7 1.8 1 1 0 1 1 1 0 Tropomyosin like TMF_DNA_bd PF12329.6 T028596_3 - 1.8 8.5 5.9 18 5.3 0.8 2.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding LRAT PF04970.11 T060397_2 - 2.7e-35 121.3 0.0 3.9e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 Lecithin retinol acyltransferase Uso1_p115_head PF04869.12 T266674_3 - 1.7e-63 214.5 1.6 2.4e-63 214.0 0.0 2.1 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.11 T266674_3 - 1.3e-07 31.9 37.2 1.3e-07 31.9 37.2 3.8 2 1 1 3 3 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region ADIP PF11559.6 T266674_3 - 0.0033 17.4 6.7 0.0033 17.4 6.7 4.9 3 1 2 5 5 5 1 Afadin- and alpha -actinin-Binding DUF4407 PF14362.4 T266674_3 - 0.025 13.8 35.3 0.016 14.4 15.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TFIIA PF03153.11 T266674_3 - 0.13 12.1 32.2 0.22 11.4 32.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Atx10homo_assoc PF09759.7 T266674_3 - 0.18 11.7 6.6 0.93 9.5 0.2 4.1 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain MG1 PF11974.6 T266674_3 - 3.7 7.5 10.3 1 9.3 1.0 3.2 2 1 1 3 3 3 0 Alpha-2-macroglobulin MG1 domain Spc7 PF08317.9 T266674_3 - 3.8 6.2 61.2 0.77 8.4 19.0 3.7 1 1 3 4 4 4 0 Spc7 kinetochore protein CUE PF02845.14 T047809_3 - 0.00026 20.5 0.0 0.00044 19.8 0.0 1.3 1 0 0 1 1 1 1 CUE domain DUF2992 PF11208.6 T047809_3 - 0.26 11.4 0.6 0.46 10.6 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) IL8 PF00048.18 T024684_1 - 2.6e-12 46.6 0.1 6.8e-12 45.2 0.1 1.7 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like PHtD_u1 PF16645.3 T024684_1 - 0.28 11.5 2.6 0.31 11.4 1.2 1.8 2 0 0 2 2 2 0 Unstructured region on Pneumococcal histidine triad protein Fer4_2 PF12797.5 T024684_3 - 0.066 13.2 0.4 0.23 11.5 0.4 2.0 1 0 0 1 1 1 0 4Fe-4S binding domain Vasculin PF15337.4 T010172_1 - 5.6e-43 145.6 3.7 1.1e-42 144.7 3.7 1.5 1 0 0 1 1 1 1 Vascular protein family Vasculin-like 1 zf-C2H2 PF00096.24 T010172_1 - 0.063 13.6 0.1 0.22 11.9 0.1 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type AbLIM_anchor PF16182.3 T260716_2 - 5.2e-68 230.4 29.5 1.3e-50 173.1 14.0 3.2 1 1 2 3 3 3 3 Putative adherens-junction anchoring region of AbLIM LIM PF00412.20 T260716_2 - 3.6e-39 132.6 42.0 9.3e-14 51.3 3.0 4.8 4 0 0 4 4 4 4 LIM domain VHP PF02209.17 T260716_2 - 1.2e-15 57.2 1.0 1.2e-15 57.2 1.0 1.7 2 0 0 2 2 2 1 Villin headpiece domain Chorion_2 PF03964.13 T260716_2 - 0.36 11.5 4.4 1 10.1 4.4 1.7 1 0 0 1 1 1 0 Chorion family 2 zf-C2H2 PF00096.24 T139531_3 - 5.4e-23 80.0 22.9 2.2e-05 24.5 1.7 6.0 5 0 0 5 5 5 5 Zinc finger, C2H2 type BTB PF00651.29 T139531_3 - 1.6e-22 79.7 0.0 2.4e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 T139531_3 - 3.9e-21 73.8 18.9 0.00041 20.8 0.6 6.0 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T139531_3 - 1.3e-16 60.0 25.2 4.9e-07 29.8 0.1 6.3 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_jaz PF12171.6 T139531_3 - 7.6e-13 48.3 1.9 0.0019 18.3 0.2 5.4 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T139531_3 - 2.1e-09 37.0 14.5 0.049 13.5 0.2 5.9 5 0 0 5 5 5 3 C2H2-type zinc finger zf-met PF12874.5 T139531_3 - 3.6e-07 30.2 17.5 0.022 15.0 0.4 5.7 6 0 0 6 6 5 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 T139531_3 - 0.0012 18.4 15.7 0.39 10.4 0.3 4.9 5 0 0 5 5 5 2 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 T139531_3 - 0.0016 18.6 11.8 2.7 8.3 7.4 4.7 2 1 2 4 4 4 2 C2H2 type zinc-finger (2 copies) LIM PF00412.20 T139531_3 - 0.5 10.5 5.6 2.2 8.4 2.4 2.9 1 1 1 2 2 2 0 LIM domain Zn-ribbon_8 PF09723.8 T139531_3 - 1.8 8.6 14.6 0.44 10.6 1.3 3.8 3 1 1 4 4 4 0 Zinc ribbon domain SprT-like PF10263.7 T139531_3 - 4 7.1 9.5 6.7 6.4 1.1 2.5 1 1 0 2 2 2 0 SprT-like family zf-AN1 PF01428.14 T139531_3 - 4.1 7.5 8.3 66 3.7 0.1 4.3 4 0 0 4 4 4 0 AN1-like Zinc finger V-set PF07686.15 T100822_3 - 5.1e-10 39.3 0.0 7.4e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T100822_3 - 0.046 13.9 0.2 0.26 11.5 0.2 2.0 1 1 0 1 1 1 0 Immunoglobulin domain Cadherin PF00028.15 T290352_3 - 5.2e-76 251.1 0.1 1.2e-15 57.5 0.2 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_tail PF15974.3 T290352_3 - 2.5e-25 89.2 6.7 7.8e-25 87.6 3.1 2.4 2 0 0 2 2 2 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 T290352_3 - 5.2e-23 81.5 0.3 1.3e-22 80.2 0.3 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 T290352_3 - 0.016 15.0 0.7 12 5.9 0.0 4.1 4 0 0 4 4 4 0 Cadherin-like Cadherin_2 PF08266.10 T290352_3 - 0.096 12.4 0.0 2 8.1 0.0 2.8 3 0 0 3 3 3 0 Cadherin-like HNF-1A_C PF04813.10 T087767_1 - 4.2e-18 65.8 10.8 1.1e-17 64.5 10.8 1.7 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus Beach PF02138.16 T092834_2 - 5.6e-121 403.0 0.7 8.3e-121 402.5 0.7 1.3 1 0 0 1 1 1 1 Beige/BEACH domain DUF4704 PF15787.3 T092834_2 - 2.5e-110 368.0 2.5 2.5e-110 368.0 2.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4704) DUF1088 PF06469.9 T092834_2 - 6.5e-88 292.6 9.0 6.5e-88 292.6 9.0 2.0 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1088) PH_BEACH PF14844.4 T092834_2 - 2.6e-29 101.1 0.0 2.6e-29 101.1 0.0 3.0 4 0 0 4 4 4 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.4 T092834_2 - 1.7e-11 44.4 0.0 4.4e-11 43.0 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.30 T092834_2 - 2.4e-06 28.0 8.1 1.4 9.8 0.3 6.8 6 0 0 6 6 6 2 WD domain, G-beta repeat PIGA PF08288.10 T092834_2 - 0.052 14.0 0.4 0.2 12.1 0.4 2.0 1 0 0 1 1 1 0 PIGA (GPI anchor biosynthesis) Pkinase_Tyr PF07714.15 T079260_3 - 1e-13 51.0 0.0 1.5e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T079260_3 - 1.2e-12 47.6 0.0 1.8e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Activin_recp PF01064.21 T079260_3 - 6.3e-05 23.8 4.7 0.0001 23.2 4.7 1.3 1 0 0 1 1 1 1 Activin types I and II receptor domain Sensor PF13796.4 T079260_3 - 0.0069 16.3 0.4 0.0069 16.3 0.4 2.3 3 0 0 3 3 3 1 Putative sensor APH PF01636.21 T079260_3 - 0.025 14.3 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.15 T352555_2 - 1.6e-93 312.6 0.0 2.4e-93 312.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.11 T352555_2 - 4.3e-56 188.4 2.3 8.8e-56 187.4 2.3 1.5 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.23 T352555_2 - 9.3e-46 156.2 0.0 1.6e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 T352555_2 - 7.8e-11 42.3 0.2 3.8e-10 40.1 0.2 2.2 2 0 0 2 2 2 1 FERM central domain Kinase-like PF14531.4 T352555_2 - 0.0081 15.4 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PAT1 PF09770.7 T115764_2 - 3e-12 45.6 0.2 9e-11 40.7 0.0 2.1 2 0 0 2 2 2 2 Topoisomerase II-associated protein PAT1 Spatacsin_C PF14649.4 T115764_3 - 3.3e-102 341.5 4.5 8e-102 340.3 4.5 1.7 1 0 0 1 1 1 1 Spatacsin C-terminus V-SNARE_C PF12352.6 T149207_3 - 2.6e-11 43.5 1.8 4.6e-11 42.7 1.8 1.4 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.11 T149207_3 - 0.0019 18.0 0.2 0.0037 17.0 0.2 1.5 1 0 0 1 1 1 1 Sec20 Ig_3 PF13927.4 T236774_3 - 1.5e-63 211.2 5.2 4.6e-13 49.4 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 T236774_3 - 3.5e-58 193.5 0.0 1.5e-12 47.3 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin I-set domain fn3 PF00041.19 T236774_3 - 7.5e-46 154.3 8.7 5.6e-13 48.9 0.1 4.9 4 0 0 4 4 4 4 Fibronectin type III domain Ig_2 PF13895.4 T236774_3 - 6.2e-41 138.5 0.4 3.5e-07 30.3 0.0 6.6 6 0 0 6 6 6 5 Immunoglobulin domain ig PF00047.23 T236774_3 - 7e-40 135.0 0.1 2.8e-08 33.7 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain Bravo_FIGEY PF13882.4 T236774_3 - 4.8e-28 98.2 2.9 8.4e-28 97.5 2.9 1.4 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.15 T236774_3 - 4.4e-16 58.8 1.3 0.0097 15.9 0.3 6.5 5 1 0 5 5 5 4 Immunoglobulin V-set domain Izumo-Ig PF16706.3 T236774_3 - 9.9e-06 25.4 0.0 1.4 8.9 0.0 4.1 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 T236774_3 - 0.0018 18.2 0.2 7 6.7 0.0 4.1 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.13 T236774_3 - 0.027 14.1 0.1 0.52 10.0 0.0 2.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 ICAM_N PF03921.12 T236774_3 - 0.034 13.7 0.6 0.26 10.9 0.0 2.7 3 0 0 3 3 3 0 Intercellular adhesion molecule (ICAM), N-terminal domain DUF3585 PF12130.6 T309399_2 - 1.4e-32 112.6 21.6 2.8e-32 111.6 21.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) CH PF00307.29 T309399_2 - 1.2e-18 67.1 0.0 2.6e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain LIM PF00412.20 T309399_2 - 1.5e-05 25.0 7.2 1.5e-05 25.0 7.2 2.0 2 0 0 2 2 2 1 LIM domain CAMSAP_CH PF11971.6 T309399_2 - 0.0083 15.8 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain FAD_binding_3 PF01494.17 T309399_3 - 4.7e-06 26.0 0.0 8.2e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.12 T309399_3 - 7.6e-05 22.0 0.0 0.00013 21.1 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 T309399_3 - 0.00039 20.0 0.5 0.031 13.8 0.4 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 T309399_3 - 0.00073 18.6 0.1 0.001 18.1 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.4 T309399_3 - 0.002 17.3 0.0 0.0029 16.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 T309399_3 - 0.0052 15.4 0.0 0.0074 14.9 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.4 T309399_3 - 0.0098 16.0 0.1 0.021 14.9 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 T309399_3 - 0.012 16.0 0.1 0.021 15.2 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.10 T309399_3 - 0.013 14.4 0.0 0.021 13.7 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_7 PF13241.4 T309399_3 - 0.033 14.5 0.0 0.058 13.7 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding FlhC PF05280.9 T309399_3 - 0.064 12.8 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhC) GIDA PF01134.20 T309399_3 - 0.1 11.6 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.5 T309399_3 - 0.18 11.0 0.2 0.26 10.5 0.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase TMCO5 PF14992.4 T075746_1 - 1.6e-31 109.8 1.0 2.6e-31 109.1 1.0 1.2 1 0 0 1 1 1 1 TMCO5 family PAS_11 PF14598.4 T075746_1 - 7.4e-26 90.4 0.0 8e-21 74.1 0.0 2.3 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.10 T075746_1 - 5.3e-20 71.4 0.0 1.2e-13 51.1 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 T075746_1 - 4.9e-18 65.0 0.0 8.4e-09 35.3 0.0 2.3 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 T075746_1 - 1e-13 50.8 1.7 1e-13 50.8 1.7 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 T075746_1 - 5.6e-10 39.3 0.0 2.9e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 T075746_1 - 0.00019 21.5 0.0 0.11 12.6 0.0 2.7 2 0 0 2 2 2 2 PAS fold AA_permease_2 PF13520.4 T101056_2 - 1.4e-59 201.9 42.2 1.8e-59 201.5 42.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 T101056_2 - 8.3e-26 90.5 36.0 1.2e-25 89.9 36.0 1.2 1 0 0 1 1 1 1 Amino acid permease Glyco_transf_54 PF04666.11 T195024_1 - 5.1e-135 448.8 0.9 7.5e-135 448.3 0.9 1.2 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region zf-B_box PF00643.22 T254072_2 - 6.4e-05 22.9 3.4 6.4e-05 22.9 3.4 2.0 2 0 0 2 2 2 1 B-box zinc finger CEBP_ZZ PF16366.3 T254072_2 - 0.006 16.6 1.2 0.017 15.2 1.2 1.8 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain IBR PF01485.19 T254072_2 - 0.2 11.8 4.5 0.86 9.7 4.5 2.1 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-HIT PF04438.14 T254072_2 - 0.56 10.0 5.3 1.4 8.7 5.3 1.6 1 0 0 1 1 1 0 HIT zinc finger SOGA PF11365.6 T254072_2 - 2.8 9.0 9.9 4.9 8.2 3.3 3.2 2 1 0 2 2 2 0 Protein SOGA zf-DHHC PF01529.18 T318172_1 - 3.6e-31 107.9 11.2 3.6e-31 107.9 11.2 2.5 2 1 1 3 3 3 1 DHHC palmitoyltransferase DUF4507 PF14964.4 T318172_3 - 1.1e-122 409.3 2.6 1.4e-122 408.9 2.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4507) ASC PF00858.22 T208169_1 - 4.1e-92 309.1 0.1 6.6e-92 308.4 0.0 1.4 2 0 0 2 2 2 1 Amiloride-sensitive sodium channel I-set PF07679.14 T208169_2 - 2.3e-183 594.8 0.0 1.4e-21 76.2 0.0 10.8 11 0 0 11 11 11 10 Immunoglobulin I-set domain Pkinase PF00069.23 T208169_2 - 4.9e-109 363.6 0.0 4.1e-55 186.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 T208169_2 - 7.3e-106 346.8 0.0 1.5e-10 41.4 0.0 10.9 10 0 0 10 10 10 10 Immunoglobulin domain Ig_2 PF13895.4 T208169_2 - 4e-61 203.2 0.0 7.1e-07 29.3 0.0 10.6 10 0 0 10 10 10 10 Immunoglobulin domain ig PF00047.23 T208169_2 - 5e-55 183.5 0.0 3.1e-06 27.2 0.0 11.5 11 0 0 11 11 11 9 Immunoglobulin domain Pkinase_Tyr PF07714.15 T208169_2 - 4.8e-50 170.1 0.0 1.2e-26 93.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase SPEG_u2 PF16650.3 T208169_2 - 5.8e-32 109.5 14.4 3.8e-31 106.9 14.4 2.6 1 0 0 1 1 1 1 Unstructured region on SPEG complex protein V-set PF07686.15 T208169_2 - 1.4e-15 57.3 0.1 0.09 12.8 0.0 9.8 9 3 0 9 9 9 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 T208169_2 - 1.1e-11 44.5 0.4 2.7 8.0 0.0 8.7 9 0 0 9 9 8 2 CD80-like C2-set immunoglobulin domain fn3 PF00041.19 T208169_2 - 5.3e-08 33.0 0.2 0.013 15.7 0.1 2.7 2 0 0 2 2 2 2 Fibronectin type III domain Receptor_2B4 PF11465.6 T208169_2 - 8e-05 22.7 0.0 19 5.3 0.0 5.3 6 0 0 6 6 5 0 Natural killer cell receptor 2B4 Izumo-Ig PF16706.3 T208169_2 - 0.011 15.6 2.4 2.5 8.1 0.1 4.7 6 0 0 6 6 5 0 Izumo-like Immunoglobulin domain Kdo PF06293.12 T208169_2 - 0.018 14.2 0.7 0.046 12.9 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 T208169_2 - 0.14 11.3 0.0 0.28 10.3 0.0 1.5 2 0 0 2 2 2 0 Kinase-like APH PF01636.21 T208169_2 - 0.14 11.9 1.8 1.3 8.8 0.0 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family NTP_transferase PF00483.21 T208169_3 - 1.7e-27 96.5 0.0 2.6e-27 95.9 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.5 T208169_3 - 3.2e-07 30.7 0.0 5.9e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.22 T208169_3 - 2.9e-05 23.5 2.6 5e-05 22.7 0.3 2.2 2 0 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.3 T208169_3 - 0.24 9.3 0.1 0.34 8.9 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Erf4 PF10256.7 T376328_3 - 8e-09 35.5 0.0 1.6e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Tim54 PF11711.6 T376328_3 - 0.03 13.0 3.5 0.043 12.5 3.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2052 PF09747.7 T376328_3 - 0.049 13.6 7.7 0.077 13.0 7.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) TFIIA PF03153.11 T376328_3 - 0.38 10.6 8.1 0.53 10.1 8.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YL1 PF05764.11 T376328_3 - 0.48 10.4 15.1 0.69 9.9 15.1 1.1 1 0 0 1 1 1 0 YL1 nuclear protein PPP4R2 PF09184.9 T376328_3 - 0.71 9.3 12.9 1.1 8.6 12.9 1.1 1 0 0 1 1 1 0 PPP4R2 Myc_N PF01056.16 T376328_3 - 1.6 8.4 9.9 2.3 7.8 9.9 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Nop14 PF04147.10 T376328_3 - 3.1 5.8 17.8 4.5 5.2 17.8 1.1 1 0 0 1 1 1 0 Nop14-like family DUF1777 PF08648.10 T376328_3 - 6.2 6.9 7.5 9.4 6.3 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) 7tm_2 PF00002.22 T240893_2 - 1.5e-75 253.6 6.4 2.4e-75 252.9 6.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 T240893_2 - 2.4e-17 62.9 0.8 6.1e-17 61.5 0.8 1.8 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.9 T240893_2 - 0.08 11.9 11.7 0.12 11.3 11.7 1.1 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor 7tm_2 PF00002.22 T240893_3 - 3.1e-11 42.9 0.0 5.6e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) DUF3338 PF11819.6 T374543_3 - 6.9e-39 132.8 5.1 1.2e-38 132.0 5.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) HR1 PF02185.14 T374543_3 - 7.6 6.6 7.9 15 5.6 7.9 1.4 1 0 0 1 1 1 0 Hr1 repeat Sec6 PF06046.11 T110945_3 - 1.3e-108 363.7 0.0 1.6e-108 363.5 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec6 SR-25 PF10500.7 T110945_3 - 0.07 12.6 4.6 0.11 11.9 4.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein C1q PF00386.19 T292360_1 - 4.1e-37 127.1 0.0 6.7e-37 126.4 0.0 1.2 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 T292360_2 - 3.7e-07 29.7 15.3 6.7e-07 28.8 15.3 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Rad51 PF08423.9 T106263_1 - 0.00029 20.0 0.0 0.00044 19.5 0.0 1.2 1 0 0 1 1 1 1 Rad51 Lig_chan PF00060.24 T369926_1 - 8.8e-39 132.6 0.1 1.2e-38 132.1 0.1 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 T369926_1 - 2.8e-29 101.5 0.0 3.8e-18 65.6 0.0 2.3 2 0 0 2 2 2 2 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 T369926_1 - 7.1e-19 68.0 0.0 3e-18 65.9 0.0 1.9 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 CaM_bdg_C0 PF10562.7 T369926_1 - 1.3e-13 50.6 3.9 2.3e-13 49.8 3.9 1.4 1 0 0 1 1 1 1 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit Ion_trans_2 PF07885.14 T369926_1 - 0.055 13.3 0.5 0.13 12.2 0.5 1.6 1 0 0 1 1 1 0 Ion channel Phosphodiest PF01663.20 T258866_3 - 1.6e-10 41.0 0.1 8.7e-07 28.7 0.0 2.1 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.16 T258866_3 - 0.01 15.0 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily PDZ PF00595.22 T378547_1 - 1.6e-07 31.5 0.0 3.3e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T378547_1 - 0.00054 20.1 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain RP-C_C PF11800.6 T378547_1 - 0.027 14.4 5.7 0.072 13.0 5.7 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region SKA1 PF07160.10 T378547_1 - 0.047 13.4 9.5 0.1 12.3 9.5 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF4834 PF16118.3 T378547_1 - 0.054 14.3 3.4 0.16 12.8 3.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Peroxin-13_N PF04088.11 T378547_1 - 0.46 10.6 3.9 0.93 9.6 3.9 1.4 1 0 0 1 1 1 0 Peroxin 13, N-terminal region EPL1 PF10513.7 T378547_1 - 0.97 9.7 6.7 2.9 8.1 6.7 1.7 1 0 0 1 1 1 0 Enhancer of polycomb-like Anoctamin PF04547.10 T378547_1 - 1.1 7.9 2.9 1.8 7.2 2.9 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel ZYG-11_interact PF05884.10 T378547_1 - 1.2 8.4 7.4 1.8 7.8 7.4 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 V_ATPase_I PF01496.17 T378547_1 - 1.5 6.5 6.5 2.2 5.9 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rpp20 PF12328.6 T378547_1 - 1.7 8.4 8.6 3.4 7.5 8.6 1.4 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P eIF-3_zeta PF05091.10 T378547_1 - 2.3 7.0 7.9 3.7 6.3 7.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CagX PF03524.13 T378547_1 - 3.2 7.3 6.1 5.5 6.5 6.1 1.2 1 0 0 1 1 1 0 Conjugal transfer protein ALMT PF11744.6 T378547_1 - 3.2 6.3 6.6 5.3 5.6 6.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Roughex PF06020.9 T378547_1 - 3.9 6.3 9.8 7.3 5.5 9.8 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.6 T378547_1 - 5.3 6.4 32.6 0.038 13.5 23.9 1.8 2 0 0 2 2 1 0 Spt20 family Presenilin PF01080.15 T378547_1 - 5.5 5.5 7.5 14 4.1 7.5 1.6 1 0 0 1 1 1 0 Presenilin Coilin_N PF15862.3 T378547_1 - 7.5 6.2 8.8 18 5.0 8.8 1.6 1 0 0 1 1 1 0 Coilin N-terminus TERB2 PF15101.4 T378547_1 - 7.8 6.4 10.3 16 5.4 10.3 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FERM_M PF00373.16 T378547_2 - 6.5e-17 61.9 0.0 1.3e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 FERM central domain Telomerase_RBD PF12009.6 T277571_3 - 7.4e-41 139.2 0.5 1.3e-40 138.4 0.5 1.4 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.25 T277571_3 - 7.7e-12 45.1 0.0 1.9e-07 30.7 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) TFIID-18kDa PF02269.14 T016763_2 - 5.7e-37 125.5 0.4 8.3e-37 125.0 0.4 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Pkinase_Tyr PF07714.15 T310352_3 - 1e-95 319.8 0.0 1.6e-95 319.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase fn3 PF00041.19 T310352_3 - 3e-48 161.9 25.4 2.3e-09 37.3 0.0 9.8 9 0 0 9 9 9 9 Fibronectin type III domain Pkinase PF00069.23 T310352_3 - 8.4e-39 133.4 0.0 1.5e-38 132.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pur_ac_phosph_N PF16656.3 T310352_3 - 0.038 14.4 10.5 2.9 8.4 3.3 5.3 4 1 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain Homeobox_KN PF05920.9 T041650_2 - 0.14 12.0 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain Pkinase PF00069.23 T041650_3 - 4.9e-62 209.5 0.0 6.3e-62 209.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T041650_3 - 1.8e-29 102.7 0.0 2.5e-29 102.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 T041650_3 - 2.9e-06 26.6 0.2 4.5e-06 26.0 0.2 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 T041650_3 - 0.0014 17.8 0.0 0.0023 17.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 T041650_3 - 0.0059 16.4 0.0 0.0093 15.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.20 T041650_3 - 0.006 16.1 0.4 0.01 15.3 0.4 1.2 1 0 0 1 1 1 1 RIO1 family CAP_N PF01213.17 T008744_1 - 9.2e-114 380.0 0.1 1.4e-113 379.4 0.1 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.9 T008744_1 - 4.2e-64 214.8 6.4 6.2e-64 214.2 6.4 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.10 T008744_1 - 0.01 15.4 2.6 0.019 14.6 2.6 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor C Spc29 PF17082.3 T008744_1 - 0.089 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Spindle Pole Component 29 Aa_trans PF01490.16 T105502_2 - 1.3e-76 257.8 41.0 1.6e-76 257.5 41.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MAT1 PF06391.11 T105502_3 - 8.2e-62 208.5 21.7 1e-61 208.2 21.7 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.3 T105502_3 - 3.3e-12 46.0 4.7 3.3e-12 46.0 4.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T105502_3 - 0.0025 17.5 4.7 0.0025 17.5 4.7 2.5 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T105502_3 - 0.0037 17.1 7.0 0.0037 17.1 7.0 3.2 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4 PF00097.23 T105502_3 - 0.0039 16.9 5.0 0.0039 16.9 5.0 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T105502_3 - 0.0066 16.3 6.7 0.0066 16.3 6.7 3.2 4 0 0 4 4 4 1 RING-type zinc-finger DZR PF12773.5 T105502_3 - 0.099 12.5 6.6 0.76 9.7 6.6 2.5 1 1 0 1 1 1 0 Double zinc ribbon zf-UDP PF14569.4 T105502_3 - 0.2 11.7 8.7 0.26 11.3 0.8 2.8 1 1 1 2 2 2 0 Zinc-binding RING-finger zf-RING_4 PF14570.4 T105502_3 - 1.3 8.6 7.5 0.34 10.6 0.4 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.4 T105502_3 - 1.9 8.3 14.3 0.05 13.3 5.7 3.0 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 T105502_3 - 3.9 7.3 14.5 0.84 9.4 6.7 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 FBP_C PF16571.3 T186596_1 - 0.023 14.1 0.0 0.039 13.3 0.0 1.2 1 0 0 1 1 1 0 FBP C-terminal treble-clef zinc-finger TMEM214 PF10151.7 T186596_2 - 1.3e-247 823.4 0.0 1.5e-247 823.2 0.0 1.1 1 0 0 1 1 1 1 TMEM214, C-terminal, caspase 4 activator Peptidase_M14 PF00246.22 T186596_3 - 1.5e-10 41.2 0.0 2.9e-10 40.3 0.0 1.5 1 1 0 1 1 1 1 Zinc carboxypeptidase Sema PF01403.17 T116231_2 - 3.7e-131 437.7 0.0 7.9e-131 436.6 0.0 1.4 1 0 0 1 1 1 1 Sema domain PRT_C PF08372.8 T116231_2 - 0.34 10.5 1.8 0.86 9.2 1.8 1.6 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal Ninjurin PF04923.10 T071272_3 - 1.9e-34 117.5 8.4 2.4e-34 117.2 8.4 1.1 1 0 0 1 1 1 1 Ninjurin C2 PF00168.28 T349092_2 - 1.1e-36 125.1 0.0 5.1e-19 68.4 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 T349092_2 - 6.2e-15 55.3 13.2 1.3e-14 54.3 13.2 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger PDZ PF00595.22 T349092_2 - 1.3e-05 25.3 0.0 2.5e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) ADK PF00406.20 T355223_2 - 5.5e-49 166.0 0.0 7.5e-49 165.6 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.4 T355223_2 - 1.4e-16 61.0 0.0 2.1e-16 60.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.12 T355223_2 - 5.2e-15 55.0 0.0 1.2e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.4 T355223_2 - 5.3e-05 23.6 0.0 8.7e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain DUF1387 PF07139.9 T078139_1 - 4e-121 404.3 14.4 6e-121 403.7 14.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1387) 7TMR-HDED PF07697.9 T078139_1 - 0.05 13.6 0.0 0.22 11.5 0.0 1.8 1 1 0 1 1 1 0 7TM-HD extracellular DUF1296 PF06972.9 T078139_1 - 1.1 9.4 3.9 0.34 11.0 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) ABC_tran PF00005.25 T304044_1 - 6.2e-32 110.8 0.0 8.7e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 T304044_1 - 0.00031 20.1 0.0 0.015 14.6 0.0 2.0 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 T304044_1 - 0.011 15.4 0.2 1.8 8.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 T304044_1 - 0.043 13.4 0.0 0.094 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF87 PF01935.15 T304044_1 - 0.067 13.1 0.1 0.1 12.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_16 PF13191.4 T304044_1 - 0.12 12.6 1.2 0.29 11.4 1.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC_membrane PF00664.21 T304044_2 - 2.3e-49 168.4 6.3 8.3e-31 107.5 0.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 T304044_2 - 2.1e-19 70.3 0.0 3.3e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 T304044_2 - 0.0031 16.8 0.1 2.2 7.5 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain KAP_NTPase PF07693.12 T304044_2 - 0.13 11.4 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain MMR_HSR1 PF01926.21 T304044_2 - 0.23 11.4 0.1 0.39 10.7 0.1 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Longin PF13774.4 T240914_1 - 7.3e-10 38.6 0.0 1.4e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF4795 PF16043.3 T154830_1 - 3e-66 222.8 4.9 3e-66 222.8 4.9 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF4795) Pribosyl_synth PF14572.4 T154830_3 - 1.5e-98 328.2 1.0 2.2e-98 327.6 1.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.4 T154830_3 - 1.1e-37 128.3 0.2 1.9e-37 127.6 0.2 1.3 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.25 T154830_3 - 1.6e-05 24.3 0.1 2.9e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain TMCO5 PF14992.4 T229430_1 - 1.6e-07 31.1 0.0 1.6e-07 31.1 0.0 1.7 2 0 0 2 2 2 1 TMCO5 family DUF972 PF06156.11 T229430_1 - 0.0015 19.0 1.0 0.73 10.4 0.4 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF972) TMEM191C PF15194.4 T229430_1 - 0.03 14.3 1.0 0.058 13.4 1.0 1.4 1 0 0 1 1 1 0 TMEM191C family DUF4391 PF14335.4 T229430_1 - 0.42 10.1 1.4 0.72 9.4 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) NYD-SP28_assoc PF14775.4 T229430_1 - 1.5 8.8 3.4 3.4 7.7 3.4 1.6 1 0 0 1 1 1 0 Sperm tail C-terminal domain ABC_membrane PF00664.21 T097741_1 - 1.3e-75 254.4 34.9 4.3e-46 157.6 10.7 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 T097741_1 - 2.1e-55 186.9 0.2 4.5e-30 104.8 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 T097741_1 - 9.3e-12 44.7 1.8 0.013 14.9 0.1 4.2 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.21 T097741_1 - 3.6e-07 30.1 0.5 0.0033 17.3 0.2 2.7 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.4 T097741_1 - 5.5e-07 29.6 1.2 0.39 10.3 0.2 4.4 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 T097741_1 - 8.8e-07 28.4 0.4 0.039 13.5 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.4 T097741_1 - 1.7e-06 28.4 0.2 0.0091 16.3 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.14 T097741_1 - 3.5e-06 26.9 0.1 0.071 12.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Dynamin_N PF00350.21 T097741_1 - 0.00092 19.2 2.8 0.14 12.1 0.1 2.6 2 1 0 2 2 2 2 Dynamin family AAA_22 PF13401.4 T097741_1 - 0.0017 18.5 1.1 2 8.5 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.4 T097741_1 - 0.0031 17.1 0.4 1.3 8.6 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.4 T097741_1 - 0.0048 17.3 0.1 0.97 9.8 0.1 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.15 T097741_1 - 0.0054 16.4 1.6 1.4 8.5 0.0 3.3 4 0 0 4 4 4 1 IstB-like ATP binding protein T2SSE PF00437.18 T097741_1 - 0.023 13.6 0.0 1.1 8.2 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.17 T097741_1 - 0.051 13.0 0.7 3.1 7.2 0.1 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF815 PF05673.11 T097741_1 - 0.12 11.4 0.3 5.4 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA PF00004.27 T097741_1 - 0.13 12.6 0.7 14 6.0 0.0 3.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.10 T097741_1 - 0.15 11.2 0.3 9.4 5.3 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.15 T097741_1 - 0.17 11.8 1.0 0.67 9.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF87 Zona_pellucida PF00100.21 T015102_1 - 3.2e-42 144.9 0.2 4.9e-42 144.3 0.2 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain Delta_lysin PF05372.9 T015102_1 - 0.13 11.5 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 Delta lysin family Pkinase_Tyr PF07714.15 T242702_2 - 5.3e-88 294.5 0.0 7.2e-88 294.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 T242702_2 - 9.2e-45 153.0 0.0 1.3e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 Sema domain Pkinase PF00069.23 T242702_2 - 2e-37 128.8 0.0 2.9e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.22 T242702_2 - 1.9e-22 79.0 0.3 1.2e-09 37.9 0.1 3.7 3 0 0 3 3 3 3 IPT/TIG domain PSI PF01437.23 T242702_2 - 0.00064 20.1 17.3 0.00064 20.1 17.3 2.3 2 0 0 2 2 2 1 Plexin repeat Kinase-like PF14531.4 T242702_2 - 0.0012 18.1 0.0 0.0018 17.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Gasdermin PF04598.10 T353507_1 - 3.2e-165 550.5 0.0 1.8e-111 373.3 0.0 2.1 2 0 0 2 2 2 2 Gasdermin family SRCR PF00530.16 T341019_1 - 7.5e-31 106.5 7.6 9.1e-31 106.2 3.0 2.6 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Collagen PF01391.16 T341019_1 - 1.4e-13 50.2 49.5 3.4e-08 33.0 20.6 2.8 2 1 1 3 3 3 2 Collagen triple helix repeat (20 copies) SRCR_2 PF15494.4 T341019_1 - 1.7e-05 25.2 1.3 5.2e-05 23.5 0.1 2.2 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain IncA PF04156.12 T341019_1 - 0.058 13.0 2.2 0.085 12.5 2.2 1.2 1 0 0 1 1 1 0 IncA protein RasGEF PF00617.17 T366677_1 - 5.5e-31 107.9 1.5 6.4e-23 81.7 0.4 3.0 1 1 2 3 3 3 2 RasGEF domain PH PF00169.27 T366677_1 - 9.2e-11 42.1 0.0 1.7e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 PH domain Yae1_N PF09811.7 T337510_1 - 0.082 12.5 3.6 0.19 11.4 3.6 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal CUB PF00431.18 T011386_3 - 8.4e-31 106.4 0.0 1.2e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 CUB domain Ig_3 PF13927.4 T028765_3 - 6e-75 247.7 0.0 5.7e-14 52.4 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 T028765_3 - 1.3e-70 233.3 0.0 8e-14 51.3 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.4 T028765_3 - 8.1e-48 160.5 0.0 8.5e-09 35.5 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 T028765_3 - 1.7e-39 133.7 0.0 1.3e-06 28.4 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.19 T028765_3 - 2.1e-35 120.8 14.4 1.1e-10 41.5 0.1 4.5 4 0 0 4 4 4 4 Fibronectin type III domain Bravo_FIGEY PF13882.4 T028765_3 - 3.2e-27 95.6 5.2 8.3e-27 94.3 5.2 1.8 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.15 T028765_3 - 5.9e-16 58.5 4.1 0.0023 17.9 0.0 8.3 7 3 1 8 8 8 3 Immunoglobulin V-set domain Ig_5 PF16681.3 T028765_3 - 4.2e-09 36.6 0.0 0.033 14.5 0.0 4.1 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 T028765_3 - 8.1e-07 28.9 0.1 1 9.4 0.0 5.4 6 0 0 6 6 6 2 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.10 T028765_3 - 0.0035 17.2 0.0 0.11 12.4 0.0 2.9 2 0 0 2 2 2 1 Penicillin-Binding Protein C-terminus Family Izumo-Ig PF16706.3 T028765_3 - 0.0063 16.4 0.2 17 5.4 0.0 3.5 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 T028765_3 - 0.11 12.5 0.1 14 5.8 0.0 2.6 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 WW PF00397.24 T068106_1 - 1.3e-05 24.9 0.0 3.9e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 WW domain Pkinase PF00069.23 T271076_1 - 6.8e-71 238.6 0.1 1.1e-70 237.9 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T271076_1 - 6.1e-45 153.4 0.4 2e-44 151.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase POLO_box PF00659.16 T271076_1 - 9.3e-09 35.2 0.1 1e-07 31.9 0.0 2.6 2 0 0 2 2 2 1 POLO box duplicated region Kinase-like PF14531.4 T271076_1 - 0.0027 16.9 0.0 0.0063 15.7 0.0 1.6 1 1 0 1 1 1 1 Kinase-like DUF4520 PF15016.4 T271076_1 - 0.0035 17.3 0.3 0.15 12.1 0.0 3.1 4 0 0 4 4 4 1 Domain of unknown function (DUF4520) FERM_M PF00373.16 T378553_1 - 6.7e-17 61.8 0.0 1.4e-16 60.8 0.0 1.5 1 0 0 1 1 1 1 FERM central domain PDZ PF00595.22 T378553_1 - 2.8e-09 37.1 0.0 4.6e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T378553_1 - 0.00017 21.7 0.0 0.00031 20.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain RP-C_C PF11800.6 T378553_3 - 0.029 14.3 5.7 0.074 13.0 5.7 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region SKA1 PF07160.10 T378553_3 - 0.05 13.3 9.5 0.11 12.2 9.5 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF4834 PF16118.3 T378553_3 - 0.057 14.3 3.4 0.17 12.8 3.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Peroxin-13_N PF04088.11 T378553_3 - 0.48 10.5 3.9 0.96 9.6 3.9 1.4 1 0 0 1 1 1 0 Peroxin 13, N-terminal region EPL1 PF10513.7 T378553_3 - 1 9.6 6.7 3 8.1 6.7 1.7 1 0 0 1 1 1 0 Enhancer of polycomb-like Anoctamin PF04547.10 T378553_3 - 1.1 7.8 2.9 1.8 7.1 2.9 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel ZYG-11_interact PF05884.10 T378553_3 - 1.2 8.3 7.4 1.9 7.7 7.4 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 V_ATPase_I PF01496.17 T378553_3 - 1.5 6.5 6.5 2.3 5.9 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rpp20 PF12328.6 T378553_3 - 1.8 8.4 8.6 3.5 7.4 8.6 1.4 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P eIF-3_zeta PF05091.10 T378553_3 - 2.4 6.9 7.9 3.9 6.2 7.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CagX PF03524.13 T378553_3 - 3.3 7.2 6.1 5.7 6.4 6.1 1.2 1 0 0 1 1 1 0 Conjugal transfer protein ALMT PF11744.6 T378553_3 - 3.4 6.3 6.6 5.5 5.6 6.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Roughex PF06020.9 T378553_3 - 4.1 6.3 9.8 7.5 5.4 9.8 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.15 T378553_3 - 5.8 5.4 7.5 15 4.1 7.5 1.6 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.6 T378553_3 - 6 6.3 32.7 0.039 13.4 23.9 1.8 2 0 0 2 2 1 0 Spt20 family Coilin_N PF15862.3 T378553_3 - 7.9 6.1 8.8 18 5.0 8.8 1.5 1 0 0 1 1 1 0 Coilin N-terminus TERB2 PF15101.4 T378553_3 - 8.1 6.3 10.3 17 5.3 10.3 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 7tm_1 PF00001.19 T221641_3 - 3.4e-61 206.7 0.0 7e-61 205.7 0.0 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T221641_3 - 4.4e-05 22.9 5.7 0.0022 17.3 0.9 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 T221641_3 - 0.013 15.1 1.2 0.025 14.2 1.2 1.4 1 0 0 1 1 1 0 Olfactory receptor DUF621 PF04789.13 T221641_3 - 2.9 6.8 7.0 4.7 6.1 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF621) SAM_2 PF07647.15 T331773_1 - 2.2e-08 33.9 1.1 4.1e-07 29.9 0.2 2.5 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 T331773_1 - 1.7e-06 28.3 0.4 4.5e-06 26.9 0.4 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank_5 PF13857.4 T331773_1 - 0.00061 20.0 0.0 0.0061 16.8 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.5 T331773_1 - 0.0052 17.2 0.1 0.029 14.8 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) DUF1359 PF07097.9 T331773_1 - 0.024 14.7 2.3 3.9 7.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1359) DUF342 PF03961.11 T331773_1 - 0.58 8.6 3.1 0.95 7.9 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Ank_2 PF12796.5 T331773_2 - 1.2e-11 44.9 0.0 2e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 T331773_2 - 2e-08 34.2 0.0 0.00011 22.3 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 T331773_2 - 1.1e-07 31.4 0.7 0.0002 21.4 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.4 T331773_2 - 5e-05 23.4 0.1 0.00042 20.5 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 T331773_2 - 5.1e-05 23.6 0.0 0.0054 17.2 0.0 2.9 1 1 0 2 2 2 1 Ankyrin repeats (many copies) UCH PF00443.27 T067591_1 - 1.6e-51 175.1 0.7 2.5e-51 174.5 0.7 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 T067591_1 - 5.2e-14 52.4 3.9 7e-12 45.5 3.9 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.4 T067591_1 - 0.025 14.3 0.0 0.065 12.9 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain UIM PF02809.18 T067591_1 - 0.17 11.7 0.4 0.53 10.2 0.4 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif TPR_3 PF07720.10 T067591_1 - 0.44 10.5 4.3 0.21 11.5 1.4 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4769 PF15992.3 T067591_1 - 1.5 8.4 8.6 0.029 14.0 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4769) ATF7IP_BD PF16788.3 T127180_1 - 2.9e-50 171.4 9.3 2.9e-50 171.4 9.3 3.2 2 1 1 3 3 3 1 ATF-interacting protein binding domain fn3_4 PF16794.3 T127180_2 - 2.1e-37 127.0 0.0 3.5e-37 126.3 0.0 1.4 1 0 0 1 1 1 1 Fibronectin-III type domain ATF7IP_BD PF16788.3 T127180_2 - 2.9e-20 73.3 5.3 4.7e-20 72.6 5.3 1.3 1 0 0 1 1 1 1 ATF-interacting protein binding domain MBT PF02820.16 T218183_2 - 2.7e-27 94.8 0.0 6.2e-27 93.6 0.0 1.7 1 0 0 1 1 1 1 mbt repeat MBT PF02820.16 T218183_3 - 8.2e-64 211.8 0.8 2.8e-32 110.7 0.2 2.4 2 0 0 2 2 2 2 mbt repeat zf-C2HC PF01530.16 T218183_3 - 4.4e-14 52.3 10.2 4.4e-14 52.3 10.2 2.3 2 0 0 2 2 2 1 Zinc finger, C2HC type GIT1_C PF12205.6 T144888_3 - 7.6e-47 158.1 0.2 7.6e-47 158.1 0.2 2.1 2 0 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term GIT_CC PF16559.3 T144888_3 - 1.1e-30 105.3 5.0 2.4e-30 104.2 5.0 1.6 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor GIT_SHD PF08518.9 T144888_3 - 8.4e-26 89.1 5.9 3.7e-13 48.7 0.5 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT ArfGap PF01412.16 T144888_3 - 9.2e-26 90.0 0.0 2.3e-25 88.7 0.0 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ank_2 PF12796.5 T144888_3 - 4.6e-10 39.8 0.0 1.1e-09 38.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T144888_3 - 8.8e-07 29.2 0.0 0.00017 21.9 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 T144888_3 - 1.9e-06 28.0 0.0 7.3e-06 26.1 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 T144888_3 - 0.00059 20.1 0.0 0.018 15.4 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Shugoshin_N PF07558.9 T144888_3 - 0.002 17.8 3.2 0.0051 16.5 3.2 1.6 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Ank_3 PF13606.4 T144888_3 - 0.011 16.1 0.0 11 6.9 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeat ZapB PF06005.10 T144888_3 - 0.023 15.0 0.1 0.075 13.4 0.1 1.9 1 0 0 1 1 1 0 Cell division protein ZapB DUF4613 PF15390.4 T144888_3 - 0.35 9.1 2.1 0.51 8.5 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DivIC PF04977.13 T144888_3 - 4.6 7.0 6.2 4.3 7.0 3.3 2.2 1 1 1 2 2 2 0 Septum formation initiator T7SS_ESX_EspC PF10824.6 T144888_3 - 5 7.5 7.4 0.6 10.5 0.3 2.7 3 0 0 3 3 2 0 Excreted virulence factor EspC, type VII ESX diderm FlxA PF14282.4 T144888_3 - 9.7 6.1 7.7 3 7.8 2.4 2.5 2 0 0 2 2 2 0 FlxA-like protein CwsA PF10814.6 T245597_1 - 0.11 12.6 0.8 0.2 11.7 0.8 1.3 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA Ig_3 PF13927.4 T245597_3 - 8.9e-17 61.4 0.0 1.5e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T245597_3 - 1.9e-14 53.4 0.0 2.9e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 T245597_3 - 5.8e-11 42.5 0.0 1e-10 41.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T245597_3 - 1.1e-06 28.5 0.0 2.3e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 T245597_3 - 0.0018 18.2 0.0 0.0031 17.4 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 T245597_3 - 0.0041 17.1 0.0 0.034 14.2 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain Peptidase_C2 PF00648.19 T124183_2 - 5e-81 271.8 0.0 6.9e-81 271.4 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease RBD-FIP PF09457.8 T124183_2 - 8.4e-20 70.3 1.3 8.4e-20 70.3 1.3 2.1 2 0 0 2 2 2 1 FIP domain zf-RanBP PF00641.16 T124183_2 - 1.4e-14 53.0 49.8 8.1e-06 24.9 0.8 6.9 7 0 0 7 7 7 5 Zn-finger in Ran binding protein and others DZR PF12773.5 T124183_2 - 3.4 7.6 44.2 2.1 8.3 8.1 5.4 4 0 0 4 4 4 0 Double zinc ribbon WD40_alt PF14077.4 T124183_2 - 3.6 7.4 6.3 0.21 11.3 0.4 2.0 2 0 0 2 2 2 0 Alternative WD40 repeat motif EF-hand_7 PF13499.4 T124183_3 - 6.4e-05 23.2 0.0 0.0001 22.5 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T124183_3 - 0.00096 18.8 0.7 0.0091 15.7 0.3 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.30 T124183_3 - 0.015 14.7 0.3 0.26 10.8 0.3 2.4 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.4 T124183_3 - 0.23 11.2 1.2 6.5 6.5 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain pair DEAD PF00270.27 T152167_2 - 8.5e-49 165.6 0.0 6.6e-48 162.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T152167_2 - 2.2e-27 95.5 0.0 7.1e-27 93.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 T152167_2 - 3.5e-06 27.0 0.0 6.1e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 T152167_2 - 0.016 14.3 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-C2H2 PF00096.24 T335741_1 - 4.6e-53 174.7 89.2 8.8e-06 25.8 1.2 11.7 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T335741_1 - 3.5e-49 163.0 79.0 3.5e-08 33.4 0.3 12.2 12 0 0 12 12 12 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 T335741_1 - 6.2e-33 110.5 87.7 0.00037 21.0 0.4 11.8 11 0 0 11 11 11 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T335741_1 - 9.3e-13 47.7 71.4 0.03 14.1 0.1 11.3 11 0 0 11 11 11 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T335741_1 - 1.9e-11 43.7 47.4 0.00074 19.5 0.1 7.4 5 1 1 6 6 6 3 Zinc ribbon domain DUF3268 PF11672.6 T335741_1 - 3.1e-05 24.1 19.6 0.13 12.5 0.1 5.3 4 2 1 6 6 6 3 zinc-finger-containing domain MBD PF01429.17 T335741_1 - 0.00027 20.4 3.8 0.44 10.2 0.1 4.9 3 3 0 3 3 3 1 Methyl-CpG binding domain zf-C2H2_11 PF16622.3 T335741_1 - 0.0025 17.4 0.9 0.065 12.9 0.1 10.8 12 0 0 12 12 11 4 zinc-finger C2H2-type zf-Di19 PF05605.10 T335741_1 - 0.0053 16.9 3.8 0.0053 16.9 3.8 5.8 3 3 2 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding CpXC PF14353.4 T335741_1 - 0.0061 16.4 36.5 4.5 7.2 0.9 10.0 4 3 7 11 11 11 1 CpXC protein zf-H2C2_5 PF13909.4 T335741_1 - 0.035 13.8 0.2 0.035 13.8 0.2 9.0 11 0 0 11 11 9 0 C2H2-type zinc-finger domain HypA PF01155.17 T335741_1 - 0.042 13.7 30.5 2.5 8.0 0.2 5.9 3 3 1 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Gin PF10764.7 T335741_1 - 0.11 12.3 1.2 50 3.8 0.0 3.9 3 0 0 3 3 3 0 Inhibitor of sigma-G Gin zf-C2H2_jaz PF12171.6 T335741_1 - 0.14 12.3 38.5 1.8 8.9 0.1 9.5 10 0 0 10 10 10 0 Zinc-finger double-stranded RNA-binding ArfGap PF01412.16 T335741_1 - 0.35 10.8 5.7 3.3 7.6 0.2 3.4 3 0 0 3 3 3 0 Putative GTPase activating protein for Arf zf-LYAR PF08790.9 T335741_1 - 0.41 10.5 16.0 0.42 10.4 0.1 6.6 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger zf-C4_ClpX PF06689.11 T335741_1 - 1.1 9.1 8.1 14 5.6 0.0 4.5 4 1 0 4 4 4 0 ClpX C4-type zinc finger Osteoregulin PF07175.9 T267843_2 - 5.1e-88 293.2 6.3 5.1e-88 293.2 6.3 2.4 3 0 0 3 3 3 1 Osteoregulin DuoxA PF10204.7 T115852_2 - 5.8e-05 22.1 0.9 8.4e-05 21.5 0.9 1.1 1 0 0 1 1 1 1 Dual oxidase maturation factor DuoxA PF10204.7 T115852_3 - 9.9e-81 270.6 0.3 3.6e-76 255.7 0.1 2.1 2 0 0 2 2 2 2 Dual oxidase maturation factor bZIP_2 PF07716.13 T173099_3 - 2.4e-14 53.0 16.9 4.2e-14 52.2 16.9 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.19 T173099_3 - 0.001 19.0 15.1 0.0014 18.6 13.0 2.1 2 0 0 2 2 2 1 bZIP transcription factor XhlA PF10779.7 T173099_3 - 0.49 10.5 3.2 0.87 9.7 3.2 1.3 1 0 0 1 1 1 0 Haemolysin XhlA DivIC PF04977.13 T173099_3 - 1.6 8.4 5.3 3.1 7.5 5.3 1.4 1 0 0 1 1 1 0 Septum formation initiator LRR_9 PF14580.4 T134659_1 - 3.9e-09 36.1 0.2 1e-08 34.8 0.2 1.6 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.4 T134659_1 - 0.056 13.1 0.3 0.15 11.7 0.3 1.8 1 0 0 1 1 1 0 Leucine rich repeat KLRAQ PF10205.7 T134659_1 - 0.074 13.2 1.8 0.2 11.8 1.8 1.7 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein DUF972 PF06156.11 T134659_1 - 0.75 10.3 11.0 7.7 7.1 2.8 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) bZIP_2 PF07716.13 T134659_1 - 0.76 9.8 11.7 6.1 6.9 4.1 2.6 2 0 0 2 2 2 0 Basic region leucine zipper DivIVA PF05103.11 T134659_1 - 0.83 9.6 6.0 0.3 11.0 1.0 2.3 2 0 0 2 2 2 0 DivIVA protein Mnd1 PF03962.13 T134659_1 - 0.92 9.2 5.0 2.8 7.6 5.0 1.8 1 0 0 1 1 1 0 Mnd1 family Sugar_tr PF00083.22 T230802_1 - 3.1e-07 29.5 0.0 0.0018 17.1 0.0 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter Sugar_tr PF00083.22 T230802_2 - 2.3e-15 56.3 1.1 3.2e-15 55.8 1.1 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MIF PF01187.16 T230802_3 - 4.3e-49 165.4 0.0 6.4e-49 164.9 0.0 1.3 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) KH_1 PF00013.27 T079323_1 - 1.1e-46 156.4 15.8 4.9e-17 61.4 0.8 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 T079323_1 - 4.6e-12 45.5 5.4 0.00065 19.3 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 T079323_1 - 0.00035 20.3 3.3 1 9.1 0.3 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 T079323_1 - 0.041 13.9 6.8 3.8 7.5 0.1 3.2 3 0 0 3 3 3 0 NusA-like KH domain DUF3534 PF12053.6 T206196_1 - 6e-54 182.1 0.0 1.8e-53 180.6 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3534) PDZ PF00595.22 T206196_1 - 7.6e-34 115.8 4.4 1.1e-16 60.8 0.2 3.6 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T206196_1 - 6.7e-12 45.4 0.1 6.4e-07 29.5 0.1 2.9 3 0 0 3 3 3 2 PDZ domain Dynein_heavy PF03028.13 T141111_2 - 1.4e-262 872.9 0.1 5.2e-261 867.8 0.0 3.0 3 0 0 3 3 3 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.11 T141111_2 - 4.6e-140 467.1 14.1 4.6e-140 467.1 14.1 3.8 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 T141111_2 - 9.7e-100 332.9 0.0 1.9e-98 328.7 0.0 2.4 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.5 T141111_2 - 2.6e-88 294.7 0.2 1.1e-87 292.7 0.2 2.2 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 T141111_2 - 4.3e-71 239.1 0.2 1.1e-70 237.7 0.0 1.8 2 0 0 2 2 1 1 P-loop containing dynein motor region D4 DHC_N1 PF08385.10 T141111_2 - 4.2e-67 226.9 0.0 4.2e-67 226.9 0.0 3.2 3 1 1 4 4 4 1 Dynein heavy chain, N-terminal region 1 AAA_7 PF12775.5 T141111_2 - 8.7e-58 195.6 0.1 1.5e-57 194.9 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.5 T141111_2 - 1.8e-52 178.4 9.1 3.2e-52 177.5 9.1 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 T141111_2 - 7.9e-34 116.5 0.0 4.9e-19 68.6 0.0 5.2 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA PF00004.27 T141111_2 - 4.9e-12 46.3 0.9 0.00011 22.4 0.0 5.3 6 0 0 6 6 5 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 T141111_2 - 5.5e-09 36.3 0.2 0.016 15.3 0.0 5.0 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.4 T141111_2 - 6.7e-08 33.0 2.4 0.02 15.1 0.0 5.6 5 0 0 5 5 4 1 AAA ATPase domain AAA_18 PF13238.4 T141111_2 - 4.5e-05 23.8 0.0 7.8 6.9 0.0 5.0 4 0 0 4 4 4 0 AAA domain TsaE PF02367.15 T141111_2 - 0.00015 21.7 0.1 1.2 9.0 0.0 3.6 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.18 T141111_2 - 0.00029 19.8 0.1 0.066 12.1 0.0 2.9 3 0 0 3 3 3 1 Type II/IV secretion system protein Mg_chelatase PF01078.19 T141111_2 - 0.00099 18.4 0.1 0.51 9.6 0.0 3.9 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.24 T141111_2 - 0.0011 18.6 0.0 0.041 13.5 0.0 3.0 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_33 PF13671.4 T141111_2 - 0.0068 16.4 0.5 1.9 8.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.4 T141111_2 - 0.012 15.2 0.7 7.2 6.1 0.0 3.3 3 0 0 3 3 3 0 AAA domain DUF3452 PF11934.6 T141111_2 - 0.025 14.0 0.1 0.21 11.0 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) AAA_2 PF07724.12 T141111_2 - 0.039 13.9 0.0 0.17 11.9 0.0 2.1 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.4 T141111_2 - 0.047 13.7 0.0 0.45 10.5 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain ResIII PF04851.13 T141111_2 - 0.05 13.5 0.0 3.8 7.3 0.0 3.2 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit IstB_IS21 PF01695.15 T141111_2 - 0.058 13.0 0.0 0.31 10.7 0.0 2.2 2 0 0 2 2 1 0 IstB-like ATP binding protein DUF815 PF05673.11 T141111_2 - 0.063 12.3 0.0 0.98 8.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) CbiA PF01656.21 T141111_2 - 0.064 13.2 0.0 0.48 10.4 0.0 2.5 2 0 0 2 2 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.4 T141111_2 - 0.066 12.6 0.7 6.8 6.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.15 T141111_2 - 0.25 11.0 2.9 0.32 10.6 0.1 2.7 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein Guanylate_kin PF00625.19 T141111_2 - 0.85 9.1 3.7 0.23 11.0 0.0 2.0 2 0 0 2 2 1 0 Guanylate kinase AAA_19 PF13245.4 T141111_2 - 1.2 9.3 4.5 8.9 6.5 0.0 4.0 4 0 0 4 4 4 0 AAA domain DUF4201 PF13870.4 T141111_2 - 8.7 5.8 27.7 8.1 5.9 8.8 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) JmjC PF02373.20 T141111_3 - 2.7e-31 108.3 1.6 5.1e-31 107.4 1.6 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Telomerase_RBD PF12009.6 T277553_2 - 3.3e-18 65.9 0.2 6.9e-18 64.9 0.2 1.5 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.25 T277553_2 - 1.4e-12 47.5 0.0 8.1e-08 31.9 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) CUT PF02376.13 T165817_2 - 1e-30 105.6 0.3 1.7e-30 104.8 0.3 1.4 1 0 0 1 1 1 1 CUT domain Homeobox PF00046.27 T165817_2 - 1.2e-08 34.5 1.1 2.1e-08 33.7 1.1 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 T165817_2 - 0.0026 17.5 0.0 0.0071 16.1 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain DUF3915 PF13054.4 T165817_2 - 0.086 12.7 6.5 4 7.3 1.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) PBP PF01161.18 T154669_2 - 5.6e-08 33.0 0.0 1.1e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein ACOX PF01756.17 T154669_3 - 5.1e-61 205.2 1.6 5.1e-61 205.2 1.6 2.0 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.4 T154669_3 - 4.3e-35 120.9 0.1 4.3e-35 120.9 0.1 3.5 4 0 0 4 4 4 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.17 T154669_3 - 8.3e-11 41.8 0.0 1.6e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain S_100 PF01023.17 T021372_2 - 1.2e-22 79.2 0.6 5.5e-12 45.1 0.0 2.7 2 0 0 2 2 2 2 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 T021372_2 - 0.00029 21.1 0.1 0.0006 20.1 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 T021372_2 - 0.00061 19.1 0.0 0.0012 18.1 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 T021372_2 - 0.0012 18.5 0.1 0.0026 17.3 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 T021372_2 - 0.018 14.4 0.1 0.049 13.1 0.1 1.8 1 0 0 1 1 1 0 EF hand LEM PF03020.13 T028850_2 - 7.4e-07 28.5 0.1 1.6e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 LEM domain Pyrophosphatase PF00719.17 T269078_2 - 9.8e-41 139.1 0.4 7.3e-26 90.7 0.0 2.1 1 1 1 2 2 2 2 Inorganic pyrophosphatase FAM27 PF15832.3 T375764_2 - 0.46 10.9 5.5 0.88 10.0 5.5 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family TNFR_c6 PF00020.16 T375764_3 - 0.0005 20.3 3.4 0.0005 20.3 3.4 2.5 3 0 0 3 3 3 1 TNFR/NGFR cysteine-rich region THRAP3_BCLAF1 PF15440.4 T008025_2 - 1.6e-197 658.5 111.3 2.6e-174 581.8 78.2 3.3 3 0 0 3 3 3 2 THRAP3/BCLAF1 family SH3_9 PF14604.4 T008025_3 - 2.3e-39 132.9 6.4 2.4e-14 52.8 0.2 3.7 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.15 T008025_3 - 1.3e-34 117.5 1.2 8e-15 54.1 0.1 3.6 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 T008025_3 - 1e-31 108.1 1.8 6e-14 51.3 0.0 3.4 3 0 0 3 3 3 3 SH3 domain Cementoin PF10511.7 T159403_1 - 0.011 15.5 0.4 1.5e+02 2.5 0.0 4.3 4 0 0 4 4 4 0 Trappin protein transglutaminase binding domain EFhand_Ca_insen PF08726.8 T159403_2 - 0.00039 20.3 0.2 0.75 9.8 0.1 2.3 2 0 0 2 2 2 2 Ca2+ insensitive EF hand DUF1992 PF09350.8 T159403_2 - 0.0048 16.9 0.3 1.8 8.7 0.0 3.0 2 1 0 2 2 2 2 Domain of unknown function (DUF1992) CENP-P PF13096.4 T159403_2 - 0.0065 16.1 5.0 31 4.1 0.1 4.5 2 2 3 5 5 5 2 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P Fn3_assoc PF13287.4 T159403_2 - 0.038 14.0 0.1 2.4e+02 1.9 0.0 4.5 3 1 2 5 5 5 0 Fn3 associated Fe_hyd_SSU PF02256.15 T159403_3 - 0.032 14.2 0.8 5.3 7.1 0.1 2.3 2 0 0 2 2 2 0 Iron hydrogenase small subunit Homeobox PF00046.27 T050148_3 - 1.9e-19 69.1 4.7 3.6e-19 68.2 4.7 1.5 1 0 0 1 1 1 1 Homeobox domain OTU PF02338.17 T020326_2 - 5e-24 85.1 0.0 7.9e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease zf-A20 PF01754.14 T020326_2 - 1.2e-05 25.0 12.2 5.5e-05 22.9 12.2 2.3 1 0 0 1 1 1 1 A20-like zinc finger UBA_4 PF14555.4 T020326_2 - 0.00031 20.4 0.0 0.00054 19.6 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.11 T020326_2 - 0.0014 18.0 0.1 0.0042 16.5 0.0 1.8 2 0 0 2 2 2 1 TAP C-terminal domain Myotub-related PF06602.12 T020326_3 - 1.3e-54 185.4 0.0 6.5e-42 143.6 0.0 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain RRM_1 PF00076.20 T020326_3 - 5.3e-37 125.4 0.0 1.4e-18 66.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 3-PAP PF12578.6 T020326_3 - 6.2e-22 77.6 0.3 1.1e-21 76.8 0.3 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein RRM_7 PF16367.3 T020326_3 - 0.0002 21.3 0.0 0.019 14.9 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif ANP PF00212.16 T003234_3 - 5.7e-11 42.3 3.3 1e-10 41.4 3.3 1.4 1 0 0 1 1 1 1 Atrial natriuretic peptide NACHT PF05729.10 T181046_1 - 9.9e-42 142.5 0.0 2.4e-41 141.3 0.0 1.7 1 0 0 1 1 1 1 NACHT domain PYRIN PF02758.14 T181046_1 - 3.6e-19 68.6 3.8 7.4e-19 67.6 1.8 2.3 2 0 0 2 2 2 1 PAAD/DAPIN/Pyrin domain LRR_6 PF13516.4 T181046_1 - 0.00035 20.2 16.1 0.15 12.1 0.0 6.6 7 0 0 7 7 7 2 Leucine Rich repeat AAA_16 PF13191.4 T181046_1 - 0.0018 18.5 0.3 0.026 14.8 0.3 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.27 T181046_1 - 0.013 15.8 0.0 0.027 14.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.20 T181046_1 - 0.023 13.6 0.0 0.062 12.2 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.4 T181046_1 - 0.025 14.7 0.4 0.11 12.6 0.1 2.3 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.4 T181046_1 - 0.05 13.6 0.0 0.23 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.4 T181046_1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.12 T181046_1 - 0.13 11.3 0.1 13 4.7 0.0 2.2 1 1 0 2 2 2 0 KAP family P-loop domain LRR_4 PF12799.5 T181046_1 - 0.52 10.7 18.2 3 8.2 0.8 5.9 4 3 1 5 5 5 0 Leucine Rich repeats (2 copies) Fmp27 PF10344.7 T144633_1 - 9.6e-63 212.4 9.2 2e-42 145.2 11.8 2.3 1 1 1 2 2 2 2 Mitochondrial protein from FMP27 Apt1 PF10351.7 T144633_2 - 1.9e-109 366.6 5.1 3.2e-109 365.8 5.1 1.4 1 1 0 1 1 1 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.7 T144633_2 - 1.1e-34 119.7 0.0 1.8e-34 119.0 0.0 1.4 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain MIR PF02815.17 T144633_2 - 1.3e-06 28.3 0.0 2.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 MIR domain DUF2405 PF10293.7 T144633_2 - 0.0018 18.1 0.0 0.003 17.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Pkinase PF00069.23 T144633_3 - 5.6e-52 176.6 0.0 8.6e-52 176.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T144633_3 - 2.1e-22 79.5 0.0 3e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T144633_3 - 4.7e-06 26.0 0.0 8.9e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like CTNNB1_binding PF08347.9 T181821_2 - 0.13 12.3 1.8 0.26 11.3 1.8 1.4 1 0 0 1 1 1 0 N-terminal CTNNB1 binding SR-25 PF10500.7 T181821_2 - 0.18 11.2 11.9 0.31 10.5 11.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.9 T181821_2 - 1.4 9.0 10.1 2.5 8.3 10.1 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Med19 PF10278.7 T181821_2 - 2.3 8.0 16.4 3.7 7.3 16.4 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Peptidase_S49_N PF08496.8 T181821_2 - 8.1 6.4 8.8 18 5.3 8.8 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal ETRAMP PF09716.8 T181821_3 - 5.6 7.0 6.5 0.26 11.3 0.1 2.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SET PF00856.26 T241912_2 - 1.4e-18 67.7 2.5 2.3e-18 67.0 0.1 2.8 2 0 0 2 2 2 1 SET domain Med26 PF08711.9 T241912_2 - 0.035 14.0 0.8 12 5.8 0.0 2.7 2 0 0 2 2 2 0 TFIIS helical bundle-like domain SRI PF08236.9 T241912_3 - 2.5e-27 94.7 7.2 5.3e-27 93.7 7.2 1.6 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain WW PF00397.24 T241912_3 - 1.8e-11 43.6 3.1 4.1e-11 42.5 3.1 1.7 1 0 0 1 1 1 1 WW domain VWA PF00092.26 T006886_1 - 5.2e-53 179.8 0.7 7e-53 179.3 0.7 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Matrilin_ccoil PF10393.7 T006886_1 - 1.6e-20 72.5 4.0 2.8e-20 71.8 1.6 2.3 2 0 0 2 2 2 1 Trimeric coiled-coil oligomerisation domain of matrilin VWA_2 PF13519.4 T006886_1 - 3.4e-16 59.7 0.0 5.6e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain FXa_inhibition PF14670.4 T006886_1 - 3.1e-09 36.8 9.8 3.1e-09 36.8 9.8 3.1 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.5 T006886_1 - 4.6e-06 26.3 3.3 4.6e-06 26.3 3.3 2.8 2 0 0 2 2 2 1 Complement Clr-like EGF-like EGF_CA PF07645.13 T006886_1 - 7.8e-05 22.7 7.4 7.8e-05 22.7 7.4 2.2 2 0 0 2 2 2 1 Calcium-binding EGF domain STAC2_u1 PF16664.3 T146681_1 - 2.9e-46 157.0 1.4 5.4e-46 156.1 1.4 1.5 1 0 0 1 1 1 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 SH3_9 PF14604.4 T146681_1 - 1.2e-15 56.9 0.0 5.8e-12 45.2 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 T146681_1 - 2.6e-12 46.0 0.2 2e-11 43.2 0.1 2.4 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 T146681_1 - 1.5e-11 43.6 1.7 1.5e-06 27.7 0.0 3.1 3 0 0 3 3 3 2 Variant SH3 domain C1_1 PF00130.20 T146681_1 - 8e-07 28.7 9.7 1.9e-06 27.5 9.7 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.14 T146681_1 - 0.013 15.7 1.1 0.03 14.5 1.1 1.6 1 0 0 1 1 1 0 C1 domain zf-RING_9 PF13901.4 T146681_1 - 0.68 9.7 5.9 1.1 9.0 5.9 1.2 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon DNA_pol_E_B PF04042.14 T061085_2 - 3.6e-45 153.8 0.2 5.1e-45 153.3 0.2 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.8 T061085_2 - 4e-10 39.9 0.0 6.1e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal Proteasome PF00227.24 T160083_1 - 4.7e-42 143.5 0.1 6.7e-42 143.0 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit BRCA2 PF00634.16 T371765_2 - 0.16 11.3 0.9 0.28 10.5 0.9 1.4 1 0 0 1 1 1 0 BRCA2 repeat zf-CCCH PF00642.22 T371765_3 - 5.4e-12 45.2 11.2 3.9e-07 29.7 5.0 3.0 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.20 T371765_3 - 0.00013 21.6 0.0 0.0003 20.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1725 PF08333.9 T371765_3 - 0.00039 19.9 2.0 0.00079 18.9 2.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Torus PF16131.3 T371765_3 - 0.12 13.0 13.8 0.66 10.6 2.7 3.1 3 0 0 3 3 3 0 Torus domain RCC1 PF00415.16 T094366_1 - 4.9e-54 180.6 32.7 6.5e-15 55.4 1.6 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 T094366_1 - 2.4e-26 90.8 31.7 6.2e-12 44.9 0.9 5.8 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.29 T094366_1 - 1.6e-18 66.8 1.8 2.7e-16 59.6 0.2 2.3 1 1 1 2 2 2 2 BTB/POZ domain BACK PF07707.13 T094366_1 - 9.2e-05 22.4 2.2 0.0014 18.6 0.2 2.8 2 1 1 3 3 3 1 BTB And C-terminal Kelch Myb_DNA-binding PF00249.29 T369133_2 - 2.5e-42 142.6 18.9 1.2e-13 50.9 0.1 5.6 5 0 0 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T369133_2 - 1.7e-31 108.1 21.4 1.3e-12 47.6 0.7 5.6 1 1 4 5 5 5 5 Myb-like DNA-binding domain CARD PF00619.19 T369133_2 - 1.7e-17 63.1 0.0 5.7e-17 61.4 0.0 2.0 1 0 0 1 1 1 1 Caspase recruitment domain SLIDE PF09111.8 T369133_2 - 5.2e-09 36.0 3.3 0.49 10.3 0.2 5.0 1 1 3 4 4 4 3 SLIDE CARD_2 PF16739.3 T369133_2 - 0.0055 16.5 0.0 0.018 14.9 0.0 2.0 1 0 0 1 1 1 1 Caspase recruitment domain HTH_23 PF13384.4 T369133_2 - 0.062 13.0 0.1 0.17 11.6 0.1 1.7 1 0 0 1 1 1 0 Homeodomain-like domain SR-25 PF10500.7 T369133_2 - 0.078 12.4 15.3 0.34 10.3 15.3 2.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DNA_PPF PF02916.13 T369133_2 - 0.89 9.8 2.1 1.9 8.7 2.1 1.5 1 0 0 1 1 1 0 DNA polymerase processivity factor SANT_DAMP1_like PF16282.3 T369133_2 - 1.6 8.8 4.4 19 5.4 0.5 3.2 2 1 1 3 3 3 0 SANT/Myb-like domain of DAMP1 DUF755 PF05501.9 T369133_2 - 2.9 8.0 10.8 20 5.4 10.8 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Secretin_N_2 PF07655.11 T369133_2 - 7.1 7.1 8.9 16 6.0 8.9 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain zf-DNL PF05180.10 T369133_3 - 2.7e-29 100.8 0.3 6.4e-29 99.5 0.3 1.7 1 0 0 1 1 1 1 DNL zinc finger JMY PF15871.3 T369133_3 - 1.5 7.9 3.2 2.2 7.4 3.2 1.1 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein DCAF15_WD40 PF14939.4 T243111_1 - 0.31 10.5 1.1 0.5 9.9 1.1 1.2 1 0 0 1 1 1 0 DDB1-and CUL4-substrate receptor 15, WD repeat PIG-P PF08510.10 T243111_1 - 0.56 10.0 3.3 1.2 8.9 3.3 1.5 1 0 0 1 1 1 0 PIG-P ANF_receptor PF01094.26 T243111_3 - 1.2e-93 314.0 0.0 1.4e-93 313.7 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 T243111_3 - 6.5e-66 222.3 14.4 6.5e-66 222.3 14.4 1.7 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 T243111_3 - 1.5e-12 47.2 10.8 4.9e-12 45.5 10.8 2.0 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Toxin_33 PF08121.9 T243111_3 - 0.58 9.9 4.2 1.5 8.6 4.2 1.7 1 0 0 1 1 1 0 Waglerin family RepA_N PF06970.9 T070345_1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Replication initiator protein A (RepA) N-terminus DUF716 PF04819.10 T070345_2 - 3.6e-32 110.8 4.6 7e-32 109.9 4.6 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF716) Ank_4 PF13637.4 T275751_3 - 6.5e-14 52.0 0.1 4.1e-09 36.7 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 T275751_3 - 6.8e-10 39.3 0.1 3.2e-09 37.1 0.1 2.0 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T275751_3 - 2.9e-08 33.7 0.2 1e-06 28.8 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 T275751_3 - 5.6e-06 26.4 0.9 0.47 10.9 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 T275751_3 - 0.0024 18.1 0.1 11 6.8 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Pkinase PF00069.23 T094853_3 - 5.9e-137 455.2 0.0 2.8e-67 226.7 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 T094853_3 - 6.1e-93 310.7 0.0 1.6e-46 158.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 T094853_3 - 2e-12 46.9 3.4 1.8e-05 24.1 0.0 3.4 3 1 1 4 4 4 2 Kinase-like Kdo PF06293.12 T094853_3 - 0.00022 20.5 0.2 0.11 11.7 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 T094853_3 - 0.00048 20.0 0.0 5.3 6.8 0.0 4.1 4 0 0 4 4 4 1 Phosphotransferase enzyme family MyTH4 PF00784.15 T154511_1 - 7.5e-20 71.3 0.1 1.7e-19 70.2 0.1 1.5 1 0 0 1 1 1 1 MyTH4 domain Myosin_head PF00063.19 T154511_1 - 1.5e-10 39.8 0.0 2.1e-10 39.4 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.4 T154511_1 - 0.011 15.9 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 T154511_1 - 0.025 14.7 0.1 0.046 13.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain Myosin_head PF00063.19 T154511_2 - 9.3e-66 222.3 0.0 1.8e-49 168.5 0.0 4.0 3 1 1 4 4 4 4 Myosin head (motor domain) SH3_2 PF07653.15 T154511_2 - 5.8e-10 38.6 0.0 1.2e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T154511_2 - 1.1e-07 31.4 0.0 1.7e-06 27.6 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 T154511_2 - 0.14 11.7 0.0 1.8 8.1 0.0 2.5 2 0 0 2 2 2 0 SH3 domain MyTH4 PF00784.15 T154511_3 - 9.6e-26 90.2 0.0 9.6e-26 90.2 0.0 2.4 3 0 0 3 3 3 1 MyTH4 domain FERM_M PF00373.16 T154511_3 - 7e-15 55.3 0.2 7e-15 55.3 0.2 1.8 2 0 0 2 2 2 1 FERM central domain PDZ PF00595.22 T106675_1 - 2.6e-20 72.4 0.1 4.2e-20 71.8 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T106675_1 - 1.1e-06 28.7 0.1 1.8e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 PDZ domain Lebercilin PF15619.4 T226298_1 - 7.2e-65 218.1 42.7 7.2e-65 218.1 42.7 2.2 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease Sec8_exocyst PF04048.12 T226298_1 - 8.3 6.2 17.6 0.11 12.3 6.1 2.8 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain DUF1515 PF07439.9 T226298_1 - 9.5 6.1 8.7 12 5.8 3.8 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) Helicase_C PF00271.29 T111223_2 - 5.4e-13 49.2 0.0 1.1e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.21 T111223_2 - 1.2e-12 47.9 0.0 2.5e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.27 T111223_2 - 6.2e-09 35.7 0.1 9.5e-09 35.1 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_14 PF13173.4 T111223_2 - 0.0062 16.4 0.1 0.047 13.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.4 T111223_2 - 0.0094 16.1 0.2 0.032 14.4 0.2 1.9 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.18 T111223_2 - 0.019 13.9 0.0 0.031 13.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.16 T111223_2 - 0.026 13.8 0.0 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_19 PF13245.4 T111223_2 - 0.028 14.6 0.1 0.047 13.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 T111223_2 - 0.07 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.4 T111223_2 - 0.15 12.4 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.14 T111223_2 - 0.19 11.0 0.0 0.34 10.2 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein TUDOR PF00567.22 T111223_3 - 1.6e-14 53.8 0.0 3e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Tudor domain DUF4460 PF14687.4 T241219_1 - 7.3e-10 38.8 0.7 1.3e-09 38.0 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) DUF4461 PF14688.4 T241219_3 - 1.1e-120 403.0 3.9 1.4e-120 402.6 3.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4461) DUF4460 PF14687.4 T241219_3 - 1.8e-09 37.5 0.2 5.2e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4460) Ion_trans PF00520.29 T071646_1 - 9.9e-249 820.6 85.2 2.5e-70 236.4 21.1 4.3 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 T071646_1 - 4.7e-37 128.4 12.3 7.1e-27 94.9 0.0 3.0 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 T071646_1 - 5.7e-36 122.0 0.0 1.2e-35 121.0 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 T071646_1 - 5.4e-30 103.4 0.1 1.1e-29 102.4 0.1 1.5 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 T071646_1 - 2.8e-07 29.4 81.1 3.4e-06 25.9 3.9 7.9 7 2 2 9 9 9 4 Polycystin cation channel DUF3338 PF11819.6 T037450_3 - 2.2e-58 196.0 5.3 4.7e-58 194.9 5.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) FERM_C PF09380.8 T037450_3 - 8e-23 80.5 0.4 1.6e-22 79.5 0.4 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 T037450_3 - 3e-19 69.4 1.4 3.3e-19 69.3 0.1 1.8 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.8 T037450_3 - 4.3e-13 48.9 0.4 9.2e-13 47.8 0.4 1.5 1 0 0 1 1 1 1 FERM N-terminal domain DUF1725 PF08333.9 T037450_3 - 0.00056 19.4 1.3 0.0012 18.3 1.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) ASXH PF13919.4 T186374_2 - 4.6e-35 120.4 0.0 9.4e-35 119.4 0.0 1.6 1 0 0 1 1 1 1 Asx homology domain PHD_3 PF13922.4 T186374_2 - 6.5e-24 84.0 6.4 1.8e-23 82.5 6.4 1.8 1 0 0 1 1 1 1 PHD domain of transcriptional enhancer, Asx HARE-HTH PF05066.11 T186374_2 - 7.6e-20 70.9 0.0 1.5e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain Uteroglobin PF01099.15 T051879_1 - 1.4e-14 53.9 0.0 2.2e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Uteroglobin family BTB PF00651.29 T007342_1 - 5.7e-25 87.6 0.9 7.3e-25 87.2 0.2 1.6 2 0 0 2 2 2 1 BTB/POZ domain DUF3342 PF11822.6 T007342_1 - 0.0002 21.4 0.1 0.0004 20.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Ribosomal_60s PF00428.17 T007342_1 - 0.016 15.6 5.9 0.038 14.4 5.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein PDGF PF00341.15 T175867_1 - 0.3 11.3 2.6 4.1 7.6 0.1 2.5 2 0 0 2 2 2 0 PDGF/VEGF domain CD225 PF04505.10 T175867_2 - 9.7e-07 28.7 0.7 9.7e-07 28.7 0.7 3.0 3 0 0 3 3 3 1 Interferon-induced transmembrane protein C2 PF00168.28 T170467_2 - 1.6e-11 44.2 0.1 3.7e-11 43.1 0.1 1.6 2 0 0 2 2 2 1 C2 domain zf-H2C2_2 PF13465.4 T046647_1 - 0.0049 17.1 0.9 0.0049 17.1 0.9 6.3 6 0 0 6 6 6 2 Zinc-finger double domain Ribosomal_S28e PF01200.16 T046647_2 - 0.071 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S28e Snf7 PF03357.19 T138746_1 - 5.1e-07 29.3 13.4 7.3e-07 28.8 13.4 1.1 1 0 0 1 1 1 1 Snf7 Peptidase_M1 PF01433.18 T362944_3 - 2.8e-23 82.7 0.0 3.7e-12 46.1 0.0 2.9 3 0 0 3 3 3 2 Peptidase family M1 zf-RING_2 PF13639.4 T336845_1 - 7.5e-06 26.0 1.2 7.5e-06 26.0 1.2 3.2 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 T336845_1 - 3.4e-05 23.6 0.9 3.4e-05 23.6 0.9 3.1 2 0 0 2 2 2 1 zinc-RING finger domain IQ PF00612.25 T336845_1 - 0.00016 21.1 3.2 0.00048 19.6 3.2 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif zf-rbx1 PF12678.5 T336845_1 - 0.00038 20.5 1.3 0.0015 18.6 1.3 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 T336845_1 - 0.00051 19.9 3.3 0.0022 17.8 0.0 3.7 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.23 T336845_1 - 0.0097 15.6 0.6 0.0097 15.6 0.6 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 T336845_1 - 0.028 14.0 11.9 0.048 13.2 6.8 3.5 2 1 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.4 T336845_1 - 0.049 13.4 4.6 0.042 13.6 1.7 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.4 T336845_3 - 5.2e-05 23.0 1.8 5.2e-05 23.0 1.8 3.1 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_11 PF17123.3 T336845_3 - 0.00078 19.0 1.7 0.0026 17.3 1.7 1.9 1 0 0 1 1 1 1 RING-like zinc finger Pentaxin PF00354.15 T366287_2 - 1.5e-17 63.8 0.0 2.3e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 T366287_2 - 3.9e-08 33.4 0.0 6.4e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily UAA PF08449.9 T296938_2 - 1.7e-12 47.1 0.8 2.4e-12 46.6 0.8 1.2 1 0 0 1 1 1 1 UAA transporter family KH_1 PF00013.27 T013607_1 - 1.5e-67 223.2 14.9 7.8e-18 63.9 0.1 4.2 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 T013607_1 - 5.9e-21 74.0 9.4 1.3e-05 24.8 0.0 4.3 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.8 T013607_1 - 1.4e-11 43.5 19.6 3.9e-07 29.3 3.7 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF1897) KH_4 PF13083.4 T013607_1 - 1.4e-06 28.0 11.0 0.14 11.9 0.1 4.2 4 0 0 4 4 4 3 KH domain Secretin_N PF03958.15 T013607_1 - 0.013 15.7 0.3 0.34 11.2 0.4 2.8 2 1 0 2 2 2 0 Bacterial type II/III secretion system short domain KH_5 PF13184.4 T013607_1 - 0.77 9.8 9.9 16 5.5 0.1 4.0 4 0 0 4 4 4 0 NusA-like KH domain Ion_trans PF00520.29 T053268_2 - 1.2e-11 44.2 14.7 2.4e-11 43.2 14.7 1.5 1 1 0 1 1 1 1 Ion transport protein dNK PF01712.17 T191947_2 - 4.4e-49 167.0 0.0 5.2e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase dNK PF01712.17 T191947_3 - 0.00036 20.3 0.0 0.00046 20.0 0.0 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase Pkinase_Tyr PF07714.15 T077223_2 - 3.7e-53 180.3 0.0 5.1e-53 179.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T077223_2 - 5.9e-52 176.5 0.1 8.3e-52 176.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain zf-H2C2_2 PF13465.4 T090528_2 - 5.7e-67 219.2 82.9 9.5e-08 32.0 0.5 13.5 14 0 0 14 14 14 10 Zinc-finger double domain zf-C2H2 PF00096.24 T090528_2 - 1.8e-40 135.0 93.4 6.2e-07 29.4 0.4 13.0 13 0 0 13 13 13 10 Zinc finger, C2H2 type KRAB PF01352.25 T090528_2 - 2.8e-24 84.4 0.1 5.4e-24 83.5 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T090528_2 - 2e-18 65.3 82.2 0.016 15.9 0.2 12.7 12 0 0 12 12 12 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T090528_2 - 8.7e-18 63.7 67.9 0.0026 17.5 0.5 11.6 11 0 0 11 11 11 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T090528_2 - 0.0015 18.6 51.3 0.77 10.0 0.9 10.5 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T090528_2 - 0.0017 18.3 55.3 0.058 13.4 1.6 8.1 3 1 8 11 11 11 8 Zinc ribbon domain PknG_rubred PF16919.3 T090528_2 - 6.3 6.8 17.1 0.25 11.3 0.2 3.9 2 1 1 4 4 4 0 Protein kinase G rubredoxin domain XPA_N PF01286.16 T090528_2 - 7.7 6.5 46.0 35 4.4 0.3 11.0 11 0 0 11 11 11 0 XPA protein N-terminal Mesothelin PF06060.10 T124578_1 - 1.1e-06 27.2 0.3 1.6e-06 26.6 0.3 1.1 1 0 0 1 1 1 1 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Mesothelin PF06060.10 T124578_2 - 0.018 13.2 0.6 0.027 12.6 0.6 1.1 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Mesothelin PF06060.10 T124578_3 - 7.7e-44 149.9 0.0 1.1e-43 149.4 0.0 1.1 1 0 0 1 1 1 1 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) LIM PF00412.20 T111855_1 - 1.4e-13 50.7 6.6 2.9e-13 49.7 6.6 1.5 1 0 0 1 1 1 1 LIM domain DUF4510 PF14971.4 T111855_3 - 3.2e-72 241.9 12.1 3.2e-72 241.9 12.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4510) DUF4509 PF14970.4 T111855_3 - 1.2e-50 171.9 0.0 1.9e-50 171.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4509) LIM PF00412.20 T111855_3 - 3.1e-24 84.8 19.3 9.8e-13 48.0 4.4 2.5 2 0 0 2 2 2 2 LIM domain zf-CCCH PF00642.22 T227100_2 - 1.3e-12 47.1 16.3 3.2e-06 26.8 2.6 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.20 T227100_2 - 6.5e-06 25.8 0.0 1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.3 T227100_2 - 2.6e-05 24.7 1.3 0.17 12.5 0.1 2.5 2 0 0 2 2 2 2 Torus domain RabGAP-TBC PF00566.16 T350557_3 - 5.6e-08 32.6 7.9 5.6e-08 32.6 7.9 2.7 1 1 1 2 2 2 1 Rab-GTPase-TBC domain WD40 PF00400.30 T350557_3 - 1.2e-05 25.8 5.8 0.95 10.3 0.2 6.0 6 0 0 6 6 6 1 WD domain, G-beta repeat Neisseria_PilC PF05567.9 T350557_3 - 0.012 14.6 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Neisseria PilC beta-propeller domain Nbas_N PF15492.4 T350557_3 - 0.035 13.3 0.1 0.39 9.9 0.0 2.5 3 0 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DUF2933 PF11666.6 T350557_3 - 0.082 12.8 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2933) C2-set_2 PF08205.10 T177014_1 - 1.8e-20 72.6 0.2 7.5e-20 70.7 0.2 2.1 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 T177014_1 - 8.6e-11 42.2 2.4 0.0069 16.8 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T177014_1 - 1.7e-09 37.6 0.0 0.018 15.1 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T177014_1 - 3.2e-09 36.8 0.0 1.6e-08 34.5 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T177014_1 - 0.0029 17.8 0.6 3.5 7.9 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.14 T177014_1 - 0.0043 17.0 0.0 2 8.4 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin I-set domain V-set PF07686.15 T177014_3 - 1.9e-06 27.9 0.0 3.8e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain BAG PF02179.14 T049550_2 - 6.1e-18 64.9 4.1 9.8e-18 64.2 4.1 1.3 1 0 0 1 1 1 1 BAG domain WW PF00397.24 T049550_2 - 4.4e-10 39.2 1.7 9.3e-10 38.2 1.7 1.6 1 0 0 1 1 1 1 WW domain GETHR PF05671.9 T040238_1 - 0.086 12.1 10.8 26 4.2 0.1 5.8 6 0 0 6 6 6 0 GETHR pentapeptide repeat (5 copies) zf-H2C2_2 PF13465.4 T040238_2 - 6.6e-78 253.8 126.1 3.4e-09 36.6 1.2 14.7 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 T040238_2 - 4.2e-61 200.0 127.8 1.1e-06 28.6 2.1 14.6 14 0 0 14 14 14 12 Zinc finger, C2H2 type KRAB PF01352.25 T040238_2 - 3.8e-23 80.8 0.0 7.1e-23 79.9 0.0 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T040238_2 - 2.7e-19 68.1 139.2 0.014 16.1 0.4 15.4 16 0 0 16 16 16 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T040238_2 - 4.1e-08 32.8 100.9 0.06 13.2 0.2 13.5 14 0 0 14 14 14 9 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T040238_2 - 0.003 18.1 59.9 1.4 9.6 2.3 6.8 4 2 2 6 6 6 5 zinc-ribbon family Zn-ribbon_8 PF09723.8 T040238_2 - 0.0058 16.6 4.1 0.0058 16.6 4.1 8.7 4 2 6 11 11 11 7 Zinc ribbon domain NUC194 PF08163.10 T343417_1 - 2e-153 511.1 0.0 3e-153 510.5 0.0 1.3 1 0 0 1 1 1 1 NUC194 domain FAT PF02259.21 T343417_1 - 7.8e-75 252.1 8.5 1.3e-74 251.4 8.5 1.4 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.25 T343417_1 - 3.6e-55 187.3 0.6 3.5e-54 184.1 0.0 2.8 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.18 T343417_1 - 8.3e-11 41.4 2.1 1.3e-10 40.8 0.2 2.2 2 0 0 2 2 2 1 FATC domain Glyco_hydro_31 PF01055.24 T115253_1 - 2.1e-151 504.9 3.0 2.9e-151 504.4 3.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Peptidase_C2 PF00648.19 T115253_1 - 4.4e-126 419.7 2.6 6.8e-126 419.1 2.6 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 T115253_1 - 2.1e-24 86.2 0.0 4.6e-24 85.2 0.0 1.5 1 0 0 1 1 1 1 Calpain large subunit, domain III Calpain_u2 PF16648.3 T115253_1 - 1e-23 83.4 3.2 2.2e-23 82.3 3.2 1.5 1 0 0 1 1 1 1 Unstructured region on Calpain-3 Gal_mutarotas_2 PF13802.4 T115253_1 - 3.6e-18 65.5 0.3 1.1e-17 63.9 0.2 2.0 2 0 0 2 2 2 1 Galactose mutarotase-like EF-hand_1 PF00036.30 T115253_1 - 1.7e-15 55.2 0.7 7.7e-05 21.8 0.0 3.8 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 T115253_1 - 2.4e-12 45.6 2.8 0.0018 18.0 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 T115253_1 - 3.3e-10 39.5 4.1 1e-07 31.4 0.2 3.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.4 T115253_1 - 9e-07 28.0 1.1 0.34 10.4 0.0 3.7 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 T115253_1 - 2.2e-06 27.9 6.3 0.032 14.6 0.6 3.4 3 1 1 4 4 4 2 EF-hand domain pair DUF5110 PF17137.2 T115253_1 - 0.0042 17.2 0.0 0.01 15.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Calpain_III PF01067.20 T115253_2 - 7.1e-24 84.6 0.1 1.2e-23 83.8 0.1 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III adh_short PF00106.23 T363181_1 - 1.5e-48 164.7 0.1 2.1e-48 164.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 T363181_1 - 1.2e-23 83.7 0.0 1.7e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 T363181_1 - 0.00014 21.7 0.0 0.00031 20.6 0.0 1.5 1 1 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.16 T363181_1 - 0.0076 16.4 0.3 0.018 15.2 0.1 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.14 T363181_1 - 0.061 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.18 T363181_1 - 0.17 11.8 0.1 0.38 10.7 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase BRCT_assoc PF12820.5 T148090_2 - 2.2e-81 271.3 1.3 2.2e-81 271.3 1.3 3.1 2 0 0 2 2 2 1 Serine-rich domain associated with BRCT BRCT PF00533.24 T148090_2 - 1.5e-18 66.8 0.0 8.3e-09 35.6 0.0 3.0 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-C3HC4 PF00097.23 T148090_2 - 1.8e-09 37.2 10.7 6.1e-09 35.5 10.7 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T148090_2 - 5.9e-09 35.5 11.1 1.7e-08 34.0 11.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T148090_2 - 1.4e-07 31.4 10.7 4.4e-07 29.8 10.7 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 T148090_2 - 4.8e-07 29.4 7.6 1.2e-06 28.2 7.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T148090_2 - 1e-06 28.5 9.0 3.2e-06 26.9 9.0 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 T148090_2 - 3.7e-06 27.0 8.6 3.7e-06 27.0 8.6 2.4 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 T148090_2 - 1.5e-05 24.7 8.7 4.7e-05 23.1 8.7 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.6 T148090_2 - 0.00025 20.7 7.4 0.00075 19.1 7.4 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 T148090_2 - 0.00045 19.9 2.1 0.001 18.8 2.1 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein BRCT_2 PF16589.3 T148090_2 - 0.00089 19.5 0.0 0.43 10.9 0.0 2.8 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain zf-ANAPC11 PF12861.5 T148090_2 - 0.0028 17.6 1.6 0.0061 16.4 1.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 T148090_2 - 0.0031 17.2 9.1 0.0076 16.0 8.0 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 T148090_2 - 0.0054 16.7 7.0 0.015 15.2 7.0 1.8 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.5 T148090_2 - 0.02 15.1 5.0 0.068 13.3 5.0 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.4 T148090_2 - 0.93 9.1 7.1 2.5 7.8 7.1 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain AMP-binding PF00501.26 T288782_2 - 4e-108 361.6 0.0 5.6e-108 361.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 T288782_2 - 0.00027 21.7 0.0 0.00052 20.8 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Y_phosphatase PF00102.25 T166734_1 - 6.2e-168 556.0 0.5 1.3e-84 283.4 0.0 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.19 T166734_1 - 5.7e-53 177.1 12.7 4.1e-16 59.0 0.0 5.6 5 0 0 5 5 5 4 Fibronectin type III domain I-set PF07679.14 T166734_1 - 1.8e-41 140.0 0.0 1.6e-16 60.0 0.0 3.9 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 T166734_1 - 9.5e-39 131.8 2.7 9.2e-12 45.3 0.0 6.0 6 0 0 6 6 6 3 Immunoglobulin domain Ig_2 PF13895.4 T166734_1 - 8.4e-23 80.4 0.1 6.5e-08 32.7 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 T166734_1 - 1.9e-16 59.9 0.0 0.0017 18.4 0.0 5.3 5 0 0 5 5 5 3 Immunoglobulin domain DSPc PF00782.18 T166734_1 - 1.4e-08 34.5 0.0 0.0076 15.9 0.0 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain V-set PF07686.15 T166734_1 - 2.4e-07 30.7 1.4 1.4 9.0 0.0 6.3 5 2 1 6 6 6 2 Immunoglobulin V-set domain Y_phosphatase3 PF13350.4 T166734_1 - 6.1e-07 29.5 0.0 0.036 13.9 0.0 2.2 2 0 0 2 2 2 2 Tyrosine phosphatase family Pur_ac_phosph_N PF16656.3 T166734_1 - 1.8e-05 25.0 10.4 0.64 10.5 0.0 6.0 5 2 0 5 5 5 2 Purple acid Phosphatase, N-terminal domain PTPlike_phytase PF14566.4 T166734_1 - 2.5e-05 24.3 0.0 0.01 15.8 0.0 2.6 2 0 0 2 2 2 1 Inositol hexakisphosphate C2-set_2 PF08205.10 T166734_1 - 2.7e-05 24.0 0.0 0.95 9.4 0.0 3.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Tissue_fac PF01108.15 T166734_1 - 0.00014 21.5 0.9 2.2 8.0 0.0 4.0 4 0 0 4 4 4 2 Tissue factor Ig_5 PF16681.3 T166734_1 - 0.00025 21.2 0.0 0.42 10.9 0.0 3.8 4 0 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Interfer-bind PF09294.8 T166734_1 - 0.01 16.0 0.0 0.58 10.4 0.0 3.0 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III SusE PF14292.4 T166734_1 - 0.14 12.4 0.1 4.8 7.5 0.0 3.0 3 0 0 3 3 3 0 SusE outer membrane protein Y_phosphatase PF00102.25 T082100_1 - 1.3e-73 247.3 0.2 1.8e-73 246.9 0.2 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 T082100_1 - 0.0017 18.1 0.0 0.003 17.2 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 T082100_1 - 0.01 15.7 0.0 0.015 15.1 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family fn3 PF00041.19 T082100_2 - 1.7e-167 544.1 43.9 8.5e-13 48.3 0.9 18.2 18 0 0 18 18 18 16 Fibronectin type III domain Y_phosphatase PF00102.25 T082100_2 - 1.1e-78 263.9 0.1 1.9e-78 263.1 0.1 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Ricin_B_lectin PF00652.20 T082100_2 - 1.8e-05 24.9 1.2 4.2e-05 23.7 1.2 1.7 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain SdrD_B PF17210.1 T082100_2 - 0.00078 19.5 19.7 2.6 8.1 0.2 7.8 8 1 1 9 9 9 2 SdrD B-like domain Y_phosphatase3 PF13350.4 T082100_2 - 0.012 15.5 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.18 T082100_2 - 0.029 14.0 0.0 0.073 12.7 0.0 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Glyco_hydro_66 PF13199.4 T082100_2 - 0.077 11.5 0.2 1 7.8 0.0 2.7 4 0 0 4 4 4 0 Glycosyl hydrolase family 66 DUF4493 PF14900.4 T082100_2 - 0.23 11.3 4.6 0.71 9.8 0.3 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4493) Pur_ac_phosph_N PF16656.3 T082100_2 - 1 9.9 31.6 0.46 11.0 0.2 9.5 8 4 0 8 8 8 0 Purple acid Phosphatase, N-terminal domain WD40 PF00400.30 T316147_1 - 6.4e-12 45.7 3.4 2.1e-07 31.4 0.3 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T316147_1 - 0.039 14.1 0.1 0.56 10.4 0.0 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 T316147_2 - 8e-14 51.7 0.1 0.0039 17.9 0.0 6.3 5 0 0 5 5 5 4 WD domain, G-beta repeat zf-C3HC4_3 PF13920.4 T126561_2 - 1.8e-13 49.9 9.3 1.8e-13 49.9 9.3 4.2 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T369979_1 - 0.0027 17.5 10.8 0.0098 15.8 10.8 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 T369979_1 - 0.0095 15.8 11.9 0.0095 15.8 11.9 2.1 2 0 0 2 2 2 1 zinc-RING finger domain GcpE PF04551.12 T369979_1 - 2.8 6.8 3.4 4.9 6.0 3.4 1.3 1 1 0 1 1 1 0 GcpE protein Beach PF02138.16 T267566_3 - 1.6e-127 424.5 0.1 2.5e-127 423.9 0.1 1.3 1 0 0 1 1 1 1 Beige/BEACH domain FYVE PF01363.19 T267566_3 - 1.9e-17 63.0 12.3 1.9e-17 63.0 12.3 2.6 2 0 0 2 2 2 1 FYVE zinc finger PH_BEACH PF14844.4 T267566_3 - 7.1e-12 45.2 0.0 1.8e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4704 PF15787.3 T267566_3 - 5.3e-07 29.0 5.3 1e-06 28.0 1.8 3.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4704) WD40 PF00400.30 T267566_3 - 0.00014 22.5 13.3 0.041 14.6 0.3 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat Laminin_G_3 PF13385.4 T267566_3 - 0.0012 18.8 0.0 0.0035 17.4 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF4800 PF16057.3 T267566_3 - 0.0019 17.4 0.8 0.0037 16.4 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) E3_UbLigase_R4 PF13764.4 T267566_3 - 0.044 11.8 0.2 0.091 10.8 0.2 1.4 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 zf-C2H2_11 PF16622.3 T162903_1 - 3.4e-18 64.9 59.6 3.3e-16 58.6 3.8 9.5 10 0 0 10 10 10 5 zinc-finger C2H2-type zf-C2H2 PF00096.24 T162903_1 - 1.4e-13 50.4 119.8 0.0033 17.7 0.5 16.1 15 0 0 15 15 15 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T162903_1 - 9.8e-08 32.1 121.0 0.0029 18.2 0.3 16.2 17 0 0 17 17 17 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T162903_1 - 5.6e-06 26.0 0.2 5.6e-06 26.0 0.2 10.9 12 0 0 12 12 12 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T162903_1 - 8.1e-06 25.9 1.8 0.00059 19.9 0.2 9.9 12 0 0 12 12 12 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T162903_1 - 0.014 15.7 0.2 0.014 15.7 0.2 10.6 10 0 0 10 10 10 0 Zinc-finger of C2H2 type Lipoxygenase PF00305.17 T139983_1 - 8.2e-56 189.6 0.0 3.4e-55 187.6 0.0 1.8 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.21 T139983_1 - 2.8e-18 66.4 0.0 5e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain zf-RING_2 PF13639.4 T336829_1 - 7.6e-06 26.0 1.2 7.6e-06 26.0 1.2 3.2 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 T336829_1 - 3.4e-05 23.6 0.9 3.4e-05 23.6 0.9 3.1 2 0 0 2 2 2 1 zinc-RING finger domain IQ PF00612.25 T336829_1 - 0.00016 21.0 3.2 0.00048 19.5 3.2 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif zf-rbx1 PF12678.5 T336829_1 - 0.00039 20.5 1.3 0.0016 18.6 1.3 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 T336829_1 - 0.00056 19.7 3.4 0.0022 17.8 0.0 3.7 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.23 T336829_1 - 0.0098 15.6 0.6 0.0098 15.6 0.6 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 T336829_1 - 0.029 13.9 11.9 0.049 13.2 6.8 3.5 2 1 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.4 T336829_1 - 0.048 13.4 4.6 0.043 13.6 1.7 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.4 T336829_3 - 5.3e-05 23.0 1.8 5.3e-05 23.0 1.8 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_11 PF17123.3 T336829_3 - 0.00079 19.0 1.7 0.0027 17.3 1.7 1.9 1 0 0 1 1 1 1 RING-like zinc finger HMG_box PF00505.17 T055378_3 - 1.2e-21 76.7 4.5 2.4e-21 75.8 4.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T055378_3 - 8.6e-09 35.7 1.1 8.6e-09 35.7 1.1 2.3 2 0 0 2 2 2 1 HMG-box domain MPS2 PF17060.3 T055378_3 - 0.23 10.5 10.7 0.4 9.8 10.7 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 Exonuc_VII_L PF02601.13 T055378_3 - 8.1 5.8 11.3 19 4.6 11.3 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lys PF00062.18 T039321_1 - 2e-11 44.1 0.3 3.2e-11 43.4 0.3 1.3 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SOGA PF11365.6 T311136_1 - 1.8e-58 195.5 55.3 2.1e-30 105.5 1.1 5.1 4 1 1 5 5 5 3 Protein SOGA DUF4482 PF14818.4 T311136_1 - 1.2e-52 178.3 13.1 1.2e-52 178.3 13.1 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4482) TSC22 PF01166.16 T311136_1 - 0.89 9.8 37.6 0.097 12.9 0.4 6.3 6 0 0 6 6 6 0 TSC-22/dip/bun family Fucokinase PF07959.10 T135469_1 - 1.1e-31 110.1 0.0 1.6e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase GHMP_kinases_C PF08544.11 T135469_1 - 1.9e-05 24.8 0.0 4.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.24 T135469_1 - 3.5e-05 23.8 0.2 0.00011 22.2 0.2 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain Fucokinase PF07959.10 T135469_2 - 9.5e-43 146.6 0.0 1.4e-42 146.0 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase GST_C_3 PF14497.4 T016951_1 - 2.6e-13 49.9 0.0 4.8e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 T016951_1 - 2e-11 43.8 0.0 3.5e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 T016951_1 - 0.001 18.7 0.1 0.0024 17.5 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 T016951_1 - 0.0054 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 T016951_2 - 6.1e-43 144.9 0.0 1.7e-20 73.0 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 T016951_2 - 1.5e-14 53.8 0.0 2.6e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 T016951_2 - 4.2e-12 46.0 0.0 7.2e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 T016951_2 - 4.3e-05 23.7 0.1 0.36 11.1 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.2 T016951_2 - 0.002 17.8 0.3 0.0043 16.7 0.3 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Xpo1 PF08389.10 T129435_2 - 3.7e-23 82.1 14.6 2.4e-22 79.5 0.1 5.8 5 1 0 5 5 5 2 Exportin 1-like protein IBN_N PF03810.17 T129435_2 - 2.6e-09 36.7 0.2 2.8e-08 33.4 0.0 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain BACK PF07707.13 T010030_1 - 0.00018 21.4 0.0 0.0003 20.7 0.0 1.2 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 T010030_2 - 8.3e-09 35.5 0.0 1.5e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Pyridoxal_deC PF00282.17 T038679_2 - 0.00039 19.1 0.0 0.00053 18.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Pyridoxal_deC PF00282.17 T038679_3 - 2.4e-100 335.8 0.3 3.2e-100 335.3 0.3 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 T038679_3 - 0.0013 17.6 0.0 0.0032 16.4 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 T038679_3 - 0.0092 15.2 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pkinase PF00069.23 T361801_1 - 1.7e-42 145.5 0.0 2.1e-39 135.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 T361801_1 - 1.5e-19 70.2 0.0 2.2e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 T361801_1 - 0.039 13.7 0.0 0.099 12.4 0.0 1.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.23 T361801_2 - 6.7e-11 41.9 0.0 1.1e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PMP22_Claudin PF00822.18 T378424_3 - 4e-21 75.5 7.1 6.1e-21 74.9 7.1 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 T378424_3 - 8.2e-05 22.3 7.9 0.00017 21.3 7.9 1.6 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.4 T378424_3 - 9.2 6.5 8.9 18 5.6 2.7 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF4064) KRAB PF01352.25 T178151_1 - 5.4e-23 80.3 0.2 1e-22 79.4 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 T178151_1 - 1.8e-22 78.5 39.7 2.6e-09 36.9 0.9 6.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 T178151_1 - 6.6e-16 57.7 32.0 0.00011 22.4 1.7 6.3 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T178151_1 - 8.3e-08 32.3 34.3 0.0047 17.5 1.5 6.8 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T178151_1 - 0.00015 21.5 28.8 0.026 14.4 1.8 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T178151_1 - 0.068 12.8 21.1 0.022 14.4 0.5 4.2 4 0 0 4 4 3 0 zinc-finger C2H2-type zf-trcl PF13451.4 T178151_1 - 0.28 11.0 8.1 2.7 7.8 0.6 3.7 3 0 0 3 3 3 0 Probable zinc-ribbon domain XPA_N PF01286.16 T178151_1 - 0.33 10.9 8.8 35 4.4 0.1 4.7 4 0 0 4 4 4 0 XPA protein N-terminal zf-C2H2_jaz PF12171.6 T178151_1 - 0.35 11.1 12.0 0.037 14.2 1.7 3.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T178151_1 - 2.2 8.3 19.6 5.1 7.2 5.6 4.2 1 1 2 4 4 4 0 Zinc ribbon domain zf-BED PF02892.13 T178151_1 - 2.6 8.0 18.5 2.4 8.1 4.3 4.1 1 1 2 3 3 3 0 BED zinc finger Zn_Tnp_IS1595 PF12760.5 T178151_1 - 4.3 7.3 14.6 12 5.8 4.9 3.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-C2HE PF16278.3 T178151_1 - 7 7.1 16.6 2.3 8.6 5.7 3.2 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.4 T178151_1 - 9.7 6.1 10.8 12 5.8 0.2 3.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type HTH_Tnp_Tc5 PF03221.14 T256303_2 - 5e-07 29.5 0.1 9e-07 28.7 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Kelch_1 PF01344.23 T308409_2 - 2.9e-12 45.8 1.8 0.00046 19.6 0.1 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.4 T308409_2 - 1.6e-11 43.9 0.4 0.0021 18.2 0.0 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.13 T308409_2 - 2.8e-08 33.3 0.1 0.0041 16.9 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.4 T308409_2 - 8.9e-05 22.2 1.1 0.0031 17.3 0.0 2.6 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.4 T308409_2 - 0.00014 21.9 0.6 1.1 9.5 0.1 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.4 T308409_2 - 0.0079 16.0 0.1 4.1 7.4 0.0 2.7 2 0 0 2 2 2 2 Kelch motif BTB PF00651.29 T308409_3 - 1.7e-26 92.4 1.3 2.7e-26 91.8 0.2 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.13 T308409_3 - 2.3e-06 27.5 0.3 4.5e-06 26.6 0.3 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch JAB PF01398.19 T382709_3 - 3.5e-43 146.2 1.3 3.5e-43 146.2 1.3 2.6 2 1 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 T382709_3 - 3.8e-05 23.3 0.1 3.8e-05 23.3 0.1 1.8 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain DUF1512 PF07431.10 T046598_2 - 2.5 6.9 4.7 0.36 9.6 0.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1512) RR_TM4-6 PF06459.10 T114050_1 - 8.8e-17 61.7 0.2 8.8e-17 61.7 0.2 2.8 3 0 0 3 3 3 1 Ryanodine Receptor TM 4-6 EF-hand_1 PF00036.30 T114050_1 - 2.6e-05 23.3 0.1 6.5e-05 22.1 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.4 T114050_1 - 0.0003 20.4 0.1 0.0012 18.5 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 T114050_1 - 0.0011 18.6 0.5 0.0011 18.6 0.5 2.2 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.4 T114050_1 - 0.0017 18.7 1.1 0.0045 17.3 1.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 T114050_1 - 0.016 14.6 0.0 0.033 13.6 0.0 1.5 1 0 0 1 1 1 0 EF hand RIH_assoc PF08454.9 T114050_3 - 1.1e-30 105.4 0.2 1.1e-30 105.4 0.2 1.7 2 0 0 2 2 2 1 RyR and IP3R Homology associated ADAM_spacer1 PF05986.12 T278320_3 - 3.7e-37 126.7 0.0 6.4e-37 125.9 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Pep_M12B_propep PF01562.17 T278320_3 - 1.8e-33 115.6 0.1 3.3e-33 114.8 0.1 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.17 T278320_3 - 5.5e-29 101.4 0.1 9.7e-29 100.6 0.1 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease TSP_1 PF00090.17 T278320_3 - 6.5e-25 87.0 100.6 3.1e-12 46.4 11.4 8.5 9 0 0 9 9 9 6 Thrombospondin type 1 domain PLAC PF08686.9 T278320_3 - 6.2e-12 45.9 10.5 3.8e-11 43.4 10.5 2.6 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Reprolysin_5 PF13688.4 T278320_3 - 3.1e-10 40.4 0.2 8.3e-10 39.0 0.2 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.4 T278320_3 - 1.9e-07 31.1 0.6 5.1e-07 29.7 0.6 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.4 T278320_3 - 2.9e-07 30.9 0.6 1e-06 29.1 0.0 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T278320_3 - 0.00066 19.2 0.2 0.0012 18.4 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Lipase_GDSL PF00657.20 T187037_3 - 1.9e-19 70.3 0.0 3.1e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.4 T187037_3 - 1.1e-05 25.8 0.0 6.4e-05 23.3 0.0 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family PEX11 PF05648.12 T121871_1 - 4.5e-46 157.0 0.1 6.5e-46 156.5 0.1 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Perilipin PF03036.14 T121871_3 - 3.9e-115 384.9 2.1 4.9e-115 384.6 2.1 1.1 1 0 0 1 1 1 1 Perilipin family PEX11 PF05648.12 T121871_3 - 0.15 11.4 0.1 0.26 10.6 0.1 1.4 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) DUF1220 PF06758.11 T019288_2 - 1.9e-16 60.0 3.5 4.5e-16 58.8 3.5 1.6 1 0 0 1 1 1 1 Repeat of unknown function (DUF1220) GAT PF03127.12 T019288_2 - 0.00042 20.4 8.5 0.078 13.2 1.0 2.5 2 0 0 2 2 2 2 GAT domain EGF PF00008.25 T019288_3 - 1.6e-29 101.7 81.5 2.2e-07 30.9 5.3 7.3 6 0 0 6 6 6 6 EGF-like domain EGF_CA PF07645.13 T019288_3 - 5.4e-08 32.8 6.2 5.4e-08 32.8 6.2 6.5 3 1 3 6 6 6 1 Calcium-binding EGF domain hEGF PF12661.5 T019288_3 - 6.3e-06 26.5 17.6 1e-05 25.9 6.4 8.9 8 1 0 8 8 8 5 Human growth factor-like EGF ADAM_spacer1 PF05986.12 T167635_1 - 8.1e-24 83.7 0.0 1.2e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 PLAC PF08686.9 T167635_1 - 2.4e-08 34.4 11.0 7.5e-08 32.8 11.0 2.0 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain TSP_1 PF00090.17 T167635_1 - 4.4e-07 29.9 54.8 0.0069 16.4 11.0 6.0 5 0 0 5 5 5 4 Thrombospondin type 1 domain Myosin_head PF00063.19 T167635_2 - 7.4e-248 824.1 0.0 8.8e-248 823.8 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) zf-C2H2_8 PF15909.3 T167635_2 - 6.6e-57 189.7 12.1 1.4e-56 188.7 12.1 1.6 1 0 0 1 1 1 1 C2H2-type zinc ribbon Myosin_TH1 PF06017.11 T167635_2 - 1.4e-51 174.6 0.0 2.2e-51 174.0 0.0 1.3 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Reprolysin PF01421.17 T167635_2 - 9.3e-17 61.5 0.0 1.6e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease SH3_9 PF14604.4 T167635_2 - 1.1e-13 50.6 0.2 2.3e-13 49.6 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T167635_2 - 2.2e-13 49.4 0.2 6.2e-13 48.0 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 T167635_2 - 4.4e-11 42.2 0.1 1.2e-10 40.8 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain Reprolysin_3 PF13582.4 T167635_2 - 1.3e-09 38.5 0.1 2.2e-09 37.7 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T167635_2 - 3.1e-08 33.6 0.3 5.2e-08 32.9 0.3 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 T167635_2 - 3.3e-07 30.5 0.6 5.9e-07 29.7 0.6 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.4 T167635_2 - 2.3e-05 24.0 0.6 4.3e-05 23.1 0.6 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like zf-H2C2_5 PF13909.4 T167635_2 - 0.03 13.9 1.8 0.044 13.4 0.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc-finger domain IQ PF00612.25 T167635_2 - 5.6 6.9 5.9 1.3 8.9 1.2 2.6 2 0 0 2 2 1 0 IQ calmodulin-binding motif zf-C2H2_6 PF13912.4 T167635_2 - 7.1 6.6 11.7 2 8.3 0.2 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Pep_M12B_propep PF01562.17 T167635_3 - 6.1e-31 107.4 0.0 1.1e-30 106.6 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide hSH3 PF14603.4 T167635_3 - 5.2e-30 103.7 0.0 8.5e-30 103.0 0.0 1.3 1 0 0 1 1 1 1 Helically-extended SH3 domain TSP_1 PF00090.17 T167635_3 - 1.7e-06 28.0 9.7 1.7e-06 28.0 9.7 2.8 2 0 0 2 2 2 1 Thrombospondin type 1 domain SH3_2 PF07653.15 T167635_3 - 0.0053 16.3 0.0 0.013 15.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Tetraspannin PF00335.18 T294123_3 - 1.8e-54 184.6 7.9 2.6e-54 184.1 7.9 1.3 1 0 0 1 1 1 1 Tetraspanin family IF4E PF01652.16 T294123_3 - 1.1e-52 177.9 0.3 1.7e-52 177.3 0.3 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E tRNA_Me_trans PF03054.14 T235495_1 - 0.17 10.5 0.0 0.25 9.9 0.0 1.1 1 0 0 1 1 1 0 tRNA methyl transferase tRNA_Me_trans PF03054.14 T235495_2 - 4.5e-69 232.8 0.0 6.2e-69 232.3 0.0 1.1 1 0 0 1 1 1 1 tRNA methyl transferase tRNA_Me_trans PF03054.14 T235495_3 - 1.6e-29 102.7 0.1 2.1e-29 102.3 0.1 1.1 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.12 T235495_3 - 1.5e-05 24.6 0.0 2.2e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) NAD_synthase PF02540.15 T235495_3 - 0.00061 18.8 0.0 0.00095 18.2 0.0 1.1 1 0 0 1 1 1 1 NAD synthase Asn_synthase PF00733.19 T235495_3 - 0.036 13.6 0.0 0.051 13.1 0.0 1.1 1 0 0 1 1 1 0 Asparagine synthase QueC PF06508.11 T235495_3 - 0.094 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC WD40 PF00400.30 T125371_2 - 1.4e-33 114.2 7.5 0.00012 22.7 0.0 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T125371_2 - 5e-10 39.4 0.5 0.01 16.0 0.0 4.8 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T125371_2 - 0.0005 19.0 0.2 1.9 7.2 0.0 3.9 2 1 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 T125371_2 - 0.0051 15.4 0.8 4.3 5.7 0.0 3.6 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Hira PF07569.9 T125371_2 - 0.015 14.9 0.1 0.73 9.4 0.0 2.5 1 1 1 2 2 2 0 TUP1-like enhancer of split HPS3_N PF14761.4 T125371_2 - 0.15 11.6 0.0 0.71 9.3 0.0 1.9 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 BEX PF04538.10 T378049_1 - 5e-22 78.7 21.3 8.9e-22 77.9 21.3 1.4 1 0 0 1 1 1 1 Brain expressed X-linked like family DotU PF09850.7 T378049_1 - 0.089 12.4 0.9 4.8 6.8 0.0 2.2 2 0 0 2 2 2 0 Type VI secretion system protein DotU POT1PC PF16686.3 T332449_1 - 8.9e-40 136.0 0.0 1.4e-39 135.3 0.0 1.3 1 0 0 1 1 1 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.15 T332449_1 - 8e-07 28.9 0.0 2.3e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 POT1 PF02765.15 T332449_3 - 0.0027 17.4 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 Ca_hom_mod PF14798.4 T048002_2 - 5.4e-23 81.3 0.1 9.8e-23 80.4 0.1 1.4 1 0 0 1 1 1 1 Calcium homeostasis modulator Ca_hom_mod PF14798.4 T048002_3 - 5.1e-54 182.9 0.1 6.9e-54 182.5 0.1 1.1 1 0 0 1 1 1 1 Calcium homeostasis modulator zf-H2C2_2 PF13465.4 T270524_1 - 1.7e-55 183.0 122.4 1.3e-08 34.8 0.8 16.6 16 0 0 16 16 16 13 Zinc-finger double domain zf-C2H2 PF00096.24 T270524_1 - 2.3e-51 169.4 113.7 4.9e-05 23.4 0.6 17.3 16 0 0 16 16 16 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T270524_1 - 2e-44 146.3 114.7 0.00042 20.8 0.2 17.9 16 0 0 16 16 16 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T270524_1 - 7.8e-19 67.4 90.9 0.0015 18.7 2.4 15.7 16 0 0 16 16 16 9 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T270524_1 - 7.3e-14 51.5 91.3 0.0061 16.8 0.7 15.9 15 0 0 15 15 15 10 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 T270524_1 - 4.4e-13 48.7 106.6 0.0028 17.4 0.6 17.0 16 2 1 17 17 17 9 C2H2-type zinc finger zf-Di19 PF05605.10 T270524_1 - 3e-05 24.1 78.6 0.012 15.7 1.5 9.7 6 2 2 9 9 9 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.3 T270524_1 - 0.00011 21.8 71.0 0.013 15.1 0.1 13.5 15 0 0 15 15 15 6 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 T270524_1 - 0.0037 17.4 2.5 0.0037 17.4 2.5 8.4 2 1 7 10 10 10 2 C2H2-type zinc ribbon GAGA PF09237.9 T270524_1 - 0.091 12.4 5.9 3 7.6 0.4 4.2 3 0 0 3 3 3 0 GAGA factor KRAB PF01352.25 T171497_1 - 2e-22 78.4 0.6 3.8e-22 77.6 0.6 1.4 1 0 0 1 1 1 1 KRAB box DENN PF02141.19 T021475_1 - 3.1e-58 196.7 4.9 6.9e-58 195.5 4.9 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain TORC_N PF12884.5 T021475_1 - 6.6e-17 61.9 0.1 6.6e-17 61.9 0.1 2.5 2 0 0 2 2 2 1 Transducer of regulated CREB activity, N terminus uDENN PF03456.16 T021475_1 - 1.5e-16 60.9 0.0 6e-16 58.9 0.0 2.2 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 T021475_1 - 7.6e-11 41.7 5.4 1.5e-10 40.7 5.4 1.6 1 0 0 1 1 1 1 dDENN domain TORC_M PF12885.5 T021475_1 - 6.8e-10 39.0 5.9 8.2e-09 35.5 0.1 2.9 3 0 0 3 3 3 2 Transducer of regulated CREB activity middle domain PPR_2 PF13041.4 T021475_1 - 0.0012 18.9 0.0 0.0025 17.9 0.0 1.5 1 0 0 1 1 1 1 PPR repeat family PPR_long PF17177.2 T021475_1 - 0.0068 15.6 0.0 0.014 14.6 0.0 1.4 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PROPR PPR_3 PF13812.4 T021475_1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Pentatricopeptide repeat domain MAS20 PF02064.13 T021475_1 - 2 8.4 6.0 3.9 7.5 6.0 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor SUIM_assoc PF16619.3 T021475_1 - 2.3 8.3 15.1 0.077 13.0 7.6 2.4 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.11 T021475_1 - 4.8 6.9 11.4 8.2 6.2 11.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TORC_M PF12885.5 T021475_2 - 1.4e-54 184.2 0.6 1.4e-54 184.2 0.6 2.0 2 0 0 2 2 2 1 Transducer of regulated CREB activity middle domain TORC_C PF12886.5 T021475_2 - 2.2e-27 95.3 0.0 3.9e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Transducer of regulated CREB activity, C terminus Zip PF02535.20 T021475_3 - 1.2e-55 189.0 16.4 2e-54 184.9 16.4 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter Cobl PF09469.8 T202153_2 - 3e-46 155.5 1.8 6.5e-46 154.4 0.7 2.1 2 0 0 2 2 2 1 Cordon-bleu ubiquitin-like domain RBD PF02196.13 T202153_2 - 0.00019 21.4 0.2 0.072 13.1 0.0 2.5 2 0 0 2 2 2 2 Raf-like Ras-binding domain Ank_5 PF13857.4 T220931_3 - 1.4e-07 31.5 0.0 3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 T220931_3 - 6.9e-06 26.4 0.1 2.7e-05 24.5 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 T220931_3 - 2.2e-05 24.5 0.3 6.4e-05 23.1 0.3 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.5 T220931_3 - 2.3e-05 24.8 0.0 4.6e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T220931_3 - 5.7e-05 23.1 0.1 0.00021 21.3 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeat DUF4347 PF14252.4 T312397_2 - 1.6e-16 60.4 0.0 5.1e-16 58.8 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4347) RhoGEF PF00621.18 T312397_2 - 1.6e-07 31.6 0.4 4.4e-07 30.2 0.4 1.8 1 1 0 1 1 1 1 RhoGEF domain F-box-like PF12937.5 T312397_2 - 3e-06 26.9 1.2 7.1e-06 25.7 1.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T312397_2 - 3.1e-06 26.8 0.4 1.5e-05 24.6 0.3 2.1 2 0 0 2 2 2 1 F-box domain Interfer-bind PF09294.8 T225270_1 - 2.1e-48 162.8 0.3 4.6e-29 100.7 0.0 2.5 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.15 T225270_1 - 8.7e-39 131.5 11.2 1.2e-23 82.8 0.1 4.0 4 0 0 4 4 4 2 Tissue factor fn3 PF00041.19 T225270_1 - 0.00072 19.7 1.7 0.51 10.6 0.4 3.6 4 0 0 4 4 4 2 Fibronectin type III domain Ribosomal_L13e PF01294.16 T138666_2 - 8.5e-81 270.0 7.4 1.2e-80 269.5 7.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e F5_F8_type_C PF00754.23 T358739_1 - 1.3e-27 96.2 0.0 2.3e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain Laminin_G_2 PF02210.22 T358739_1 - 6.6e-21 75.1 0.3 1e-20 74.4 0.3 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 T358739_1 - 1.1e-11 44.9 0.0 1.7e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Bradykinin PF06753.10 T358739_3 - 0.28 10.8 8.8 0.49 10.0 1.1 3.0 2 0 0 2 2 2 0 Bradykinin Ank_2 PF12796.5 T045839_1 - 1.6e-19 70.1 0.1 5.5e-10 39.6 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 T045839_1 - 6.2e-19 67.4 0.0 6.1e-07 29.5 0.0 3.8 3 1 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.4 T045839_1 - 1.5e-16 60.4 0.4 3.7e-06 27.2 0.1 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 T045839_1 - 8.4e-15 54.5 1.2 1.5e-08 34.7 0.1 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 T045839_1 - 6.8e-12 44.4 2.0 8.3e-05 22.6 0.1 4.8 4 0 0 4 4 4 2 Ankyrin repeat Skp1_POZ PF03931.13 T346044_3 - 9.4e-10 38.4 0.0 1.5e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain RRM_1 PF00076.20 T173881_1 - 0.00047 19.8 0.0 0.00076 19.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.22 T173881_2 - 0.0094 15.7 0.5 0.028 14.2 0.5 1.9 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH PF00642.22 T173881_3 - 0.026 14.3 2.4 0.059 13.2 2.4 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-Tim10_DDP PF02953.13 T054023_3 - 1.7e-13 49.9 1.1 3.8e-13 48.7 1.1 1.6 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF4207 PF13904.4 T024800_2 - 9.3 5.7 65.7 0.0076 15.9 31.1 3.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4207) MHC_I_3 PF16497.3 T022994_2 - 2.1e-93 311.2 4.4 3e-93 310.7 4.4 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 T022994_2 - 2.8e-10 40.4 0.0 5.8e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Collagen PF01391.16 T043330_2 - 2.8e-70 231.9 295.8 8.5e-10 38.1 28.1 10.9 5 3 4 10 10 10 9 Collagen triple helix repeat (20 copies) LIM PF00412.20 T003804_3 - 2.2e-28 98.1 46.1 2.5e-15 56.3 7.0 3.7 4 0 0 4 4 4 3 LIM domain Trypsin PF00089.24 T272847_2 - 2.2e-24 86.4 0.0 3.5e-24 85.7 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF4549 PF15082.4 T147475_1 - 0.36 10.6 2.0 0.75 9.5 2.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4549) Filament PF00038.19 T147475_3 - 9.9e-95 317.6 29.1 1.3e-94 317.2 29.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein FlxA PF14282.4 T147475_3 - 0.0031 17.3 14.7 0.0031 17.3 14.7 4.0 3 2 1 4 4 4 1 FlxA-like protein Spc7 PF08317.9 T147475_3 - 0.0058 15.4 27.7 0.016 14.0 17.1 2.3 2 0 0 2 2 2 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 T147475_3 - 0.01 15.8 31.1 0.061 13.2 17.1 3.3 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein SPATA1_C PF15743.3 T147475_3 - 0.013 15.4 0.1 0.013 15.4 0.1 3.8 1 1 2 3 3 2 0 Spermatogenesis-associated C-terminus Myosin_tail_1 PF01576.17 T147475_3 - 0.015 13.0 27.5 0.087 10.5 10.8 1.8 1 1 1 2 2 2 0 Myosin tail DUF2353 PF09789.7 T147475_3 - 0.027 13.8 23.3 0.11 11.7 18.2 2.3 2 0 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) Baculo_PEP_C PF04513.10 T147475_3 - 0.036 14.0 19.5 0.021 14.7 9.0 3.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus MtaB PF12176.6 T147475_3 - 0.14 10.8 3.3 0.19 10.3 3.3 1.2 1 0 0 1 1 1 0 Methanol-cobalamin methyltransferase B subunit DUF4407 PF14362.4 T147475_3 - 0.15 11.3 22.5 1 8.5 8.5 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) AAA_13 PF13166.4 T147475_3 - 0.37 9.3 24.8 1.4 7.4 21.4 2.2 1 1 1 2 2 2 0 AAA domain Reo_sigmaC PF04582.10 T147475_3 - 0.48 9.6 9.2 2 7.6 3.2 2.6 1 1 3 4 4 4 0 Reovirus sigma C capsid protein FliJ PF02050.14 T147475_3 - 0.54 10.4 28.1 7.5 6.7 6.3 4.1 3 1 1 4 4 4 0 Flagellar FliJ protein THOC7 PF05615.11 T147475_3 - 0.66 10.1 19.5 0.046 13.9 8.7 2.8 2 1 0 2 2 2 0 Tho complex subunit 7 Jnk-SapK_ap_N PF09744.7 T147475_3 - 0.68 10.0 32.4 0.33 11.0 3.4 3.8 2 1 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF5082 PF16888.3 T147475_3 - 0.72 10.1 28.3 0.34 11.1 0.8 4.5 2 1 3 5 5 5 0 Domain of unknown function (DUF5082) APG6 PF04111.10 T147475_3 - 0.75 9.0 28.2 0.8 8.9 15.6 2.6 2 1 0 2 2 2 0 Autophagy protein Apg6 FAM184 PF15665.3 T147475_3 - 0.82 9.3 26.6 0.3 10.7 18.0 2.8 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B RasGAP_C PF03836.13 T147475_3 - 0.94 9.5 30.0 0.19 11.8 5.1 3.5 2 1 1 4 4 3 0 RasGAP C-terminus IncA PF04156.12 T147475_3 - 0.98 9.0 36.9 1.1 8.9 23.8 3.1 2 1 1 3 3 3 0 IncA protein DUF4776 PF16003.3 T147475_3 - 1.7 7.4 8.4 2.1 7.1 8.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Golgin_A5 PF09787.7 T147475_3 - 1.8 7.8 31.4 2.1 7.6 4.0 2.3 1 1 0 2 2 2 0 Golgin subfamily A member 5 TBPIP PF07106.11 T147475_3 - 1.9 8.1 30.8 2.4 7.8 10.7 3.7 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Apolipoprotein PF01442.16 T147475_3 - 2.1 8.1 26.0 98 2.6 26.0 2.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain CENP-F_leu_zip PF10473.7 T147475_3 - 2.3 8.1 38.4 3.4 7.6 4.8 4.5 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.10 T147475_3 - 2.4 8.0 23.6 0.43 10.4 5.2 3.7 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) Tup_N PF08581.8 T147475_3 - 4 7.7 36.3 3.9 7.7 4.6 5.7 2 1 6 8 8 8 0 Tup N-terminal Prefoldin_2 PF01920.18 T147475_3 - 4.7 7.1 32.5 0.19 11.6 2.7 4.8 5 1 1 6 6 5 0 Prefoldin subunit ADIP PF11559.6 T147475_3 - 7.2 6.5 32.2 4.9 7.1 2.1 4.0 2 2 2 4 4 4 0 Afadin- and alpha -actinin-Binding DUF2968 PF11180.6 T147475_3 - 8.1 6.0 19.6 8.5 5.9 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) zf-H2C2_2 PF13465.4 T135724_1 - 2.3e-67 220.5 56.8 3e-08 33.6 0.7 11.8 11 0 0 11 11 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 T135724_1 - 6.4e-48 158.5 52.2 1.2e-05 25.4 0.1 10.9 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T135724_1 - 1.4e-20 72.1 68.0 0.024 15.3 0.1 11.7 11 0 0 11 11 10 9 C2H2-type zinc finger KRAB PF01352.25 T135724_1 - 6.4e-20 70.4 0.0 1.2e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 KRAB box Aminotran_1_2 PF00155.19 T135724_1 - 3e-10 39.7 0.0 3.8e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II zf-C2H2_jaz PF12171.6 T135724_1 - 3.3e-08 33.5 19.2 1.6 9.0 0.0 8.8 8 0 0 8 8 8 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T135724_1 - 5.4e-06 26.3 39.9 0.14 12.2 2.4 6.3 1 1 8 9 9 9 8 Zinc ribbon domain zf-C2H2_11 PF16622.3 T135724_1 - 5.6e-05 22.7 49.3 0.0068 16.0 0.0 10.5 10 0 0 10 10 10 4 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 T135724_1 - 0.00056 19.6 47.4 0.31 10.9 0.3 9.5 9 0 0 9 9 9 5 C2H2-type zinc finger BolA PF01722.16 T135724_1 - 0.51 10.5 8.6 4 7.7 0.9 3.9 3 1 1 4 4 4 0 BolA-like protein zinc_ribbon_15 PF17032.3 T135724_1 - 3.8 8.2 37.2 0.46 11.1 0.4 5.6 2 1 4 6 6 5 0 zinc-ribbon family Aminotran_1_2 PF00155.19 T135724_2 - 3.8e-57 194.0 0.0 5.3e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II TAT_ubiq PF07706.10 T135724_2 - 1.9e-21 75.8 2.2 4e-21 74.8 2.2 1.6 1 0 0 1 1 1 1 Aminotransferase ubiquitination site Aminotran_5 PF00266.17 T135724_2 - 0.00015 20.7 0.0 0.00022 20.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 T135724_2 - 0.0067 15.6 0.0 0.01 15.0 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.18 T135724_2 - 0.011 14.2 0.0 0.016 13.6 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_MocR PF12897.5 T135724_2 - 0.079 11.6 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase Pkinase_Tyr PF07714.15 T340933_2 - 4.9e-93 311.0 0.0 7.5e-93 310.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.11 T340933_2 - 2.5e-52 176.2 1.9 4.4e-52 175.4 1.9 1.4 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.23 T340933_2 - 1.6e-42 145.5 0.0 2.7e-42 144.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 T340933_2 - 7e-12 45.7 1.4 2.1e-11 44.2 1.4 1.7 1 0 0 1 1 1 1 FERM central domain Gly_acyl_tr_N PF06021.9 T059108_2 - 1.8e-83 279.4 1.8 2.4e-83 279.1 1.8 1.1 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.8 T059108_2 - 1.3e-41 140.5 0.3 2.3e-41 139.8 0.3 1.4 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region FR47 PF08445.8 T059108_2 - 0.00017 21.3 0.0 0.0003 20.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein F-112 PF09645.8 T059108_2 - 0.059 13.6 0.3 0.12 12.6 0.3 1.4 1 0 0 1 1 1 0 F-112 protein Ion_trans PF00520.29 T264390_2 - 2.1e-30 105.6 11.6 3.1e-30 105.0 11.6 1.2 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.3 T264390_2 - 2.4e-30 104.6 3.8 7e-30 103.1 3.8 1.9 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.27 T264390_2 - 4.6e-17 61.7 0.0 7.2e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF106 PF01956.14 T264390_2 - 0.002 17.8 0.0 0.34 10.5 0.0 2.8 2 1 0 2 2 2 1 Integral membrane protein DUF106 CDC45 PF02724.12 T264390_2 - 0.0055 15.0 8.1 0.0095 14.2 8.1 1.3 1 0 0 1 1 1 1 CDC45-like protein DDHD PF02862.15 T264390_2 - 0.0085 16.1 4.5 0.016 15.3 4.5 1.3 1 0 0 1 1 1 1 DDHD domain Connexin PF00029.17 T264390_2 - 0.031 13.9 1.5 0.05 13.2 1.5 1.3 1 0 0 1 1 1 0 Connexin SpoIIIAH PF12685.5 T264390_2 - 0.033 13.9 9.2 0.069 12.8 9.2 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein Ion_trans_2 PF07885.14 T264390_2 - 0.035 13.9 2.6 0.078 12.8 2.6 1.6 1 0 0 1 1 1 0 Ion channel NPR3 PF03666.11 T264390_2 - 0.036 12.7 8.2 0.057 12.1 8.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MCU PF04678.11 T264390_2 - 0.089 12.8 1.8 6.2 6.8 0.1 2.5 2 0 0 2 2 2 0 Mitochondrial calcium uniporter AP3D1 PF06375.9 T264390_2 - 0.094 12.9 21.0 0.23 11.6 21.0 1.6 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Tim54 PF11711.6 T264390_2 - 0.1 11.3 11.5 0.17 10.5 11.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.20 T264390_2 - 0.13 11.4 3.5 0.2 10.7 3.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.13 T264390_2 - 0.19 10.5 6.6 0.3 9.9 6.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF4746 PF15928.3 T264390_2 - 0.43 9.8 11.6 0.69 9.1 11.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_polI_A34 PF08208.9 T264390_2 - 0.51 10.3 32.9 0.92 9.4 32.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Eapp_C PF10238.7 T264390_2 - 0.61 10.0 8.3 1.3 9.0 8.3 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein RR_TM4-6 PF06459.10 T264390_2 - 0.62 9.7 20.5 0.93 9.1 20.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FGF-BP1 PF06473.10 T264390_2 - 0.64 9.7 14.1 1.1 8.9 14.1 1.3 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) DUF913 PF06025.10 T264390_2 - 1.4 7.6 6.1 2.4 6.9 6.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.15 T264390_2 - 1.5 7.3 10.7 2.4 6.7 10.7 1.2 1 0 0 1 1 1 0 Presenilin MIP-T3 PF10243.7 T264390_2 - 1.5 7.3 26.8 2.3 6.7 26.8 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Afi1 PF07792.10 T264390_2 - 2.1 8.7 14.8 4.6 7.6 14.8 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RP-C_C PF11800.6 T264390_2 - 2.2 8.2 4.2 4.7 7.1 4.2 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region Sec62 PF03839.14 T264390_2 - 2.4 7.5 19.4 0.16 11.3 14.3 1.6 2 0 0 2 2 1 0 Translocation protein Sec62 CPSF100_C PF13299.4 T264390_2 - 4.5 7.3 11.4 8.3 6.4 11.4 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FancD2 PF14631.4 T264390_2 - 6.6 3.8 10.6 9.9 3.3 10.6 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease ALMT PF11744.6 T264390_2 - 9.5 4.8 7.6 15 4.1 7.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CAGE1 PF15066.4 T124439_2 - 0.036 12.6 0.0 0.053 12.0 0.0 1.1 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family DUF4472 PF14739.4 T124439_3 - 7.2e-23 81.2 0.2 3.4e-11 43.7 0.2 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4472) Apo-VLDL-II PF05418.9 T165197_2 - 2 8.9 5.4 1e+02 3.4 0.1 4.0 4 0 0 4 4 4 0 Apovitellenin I (Apo-VLDL-II) SHIPPO-rpt PF07004.10 T165197_3 - 2.7e-11 43.7 22.7 0.00094 19.9 0.0 5.9 5 0 0 5 5 5 3 Sperm-tail PG-rich repeat UCH PF00443.27 T084422_1 - 1.5e-25 90.0 0.4 2.1e-25 89.5 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 T084422_1 - 0.00086 18.9 0.1 0.0011 18.5 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.27 T084422_2 - 1.5e-24 86.8 0.2 2.2e-24 86.2 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 T084422_2 - 2.6e-19 69.2 9.0 2.6e-19 69.2 9.0 2.0 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 T084422_2 - 0.0036 16.9 0.4 0.086 12.3 0.1 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase SurA_N PF09312.9 T084422_2 - 0.47 10.4 3.1 0.3 11.0 1.0 1.7 2 0 0 2 2 2 0 SurA N-terminal domain zf-LITAF-like PF10601.7 T126527_2 - 1.5e-21 76.3 13.9 1.5e-21 76.3 13.9 3.0 4 0 0 4 4 4 1 LITAF-like zinc ribbon domain RUN PF02759.17 T266211_1 - 2.6e-32 111.5 0.2 6.8e-32 110.1 0.0 1.9 2 0 0 2 2 2 1 RUN domain Trimer_CC PF08954.9 T266211_1 - 0.00018 20.9 4.9 0.13 11.7 0.0 2.7 2 0 0 2 2 2 2 Trimerisation motif FYVE PF01363.19 T266211_1 - 0.00058 19.8 3.8 0.0013 18.7 3.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger Reo_sigmaC PF04582.10 T266211_1 - 0.07 12.4 11.1 0.46 9.7 3.3 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein PAXX PF15384.4 T266211_1 - 0.44 10.1 6.7 0.79 9.2 6.7 1.3 1 0 0 1 1 1 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 XhlA PF10779.7 T266211_1 - 0.82 9.8 10.8 3.1 7.9 3.0 3.2 2 0 0 2 2 2 0 Haemolysin XhlA DUF4407 PF14362.4 T266211_1 - 4.3 6.5 27.6 1.2 8.3 9.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.10 T266211_1 - 9.5 6.1 14.4 2.1 8.2 2.5 2.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus 7tm_3 PF00003.20 T327791_2 - 6.2e-64 215.9 23.8 1.3e-63 214.8 23.8 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 T327791_2 - 2.5e-14 52.8 13.8 7.2e-14 51.4 13.8 1.9 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR TPR_2 PF07719.15 T086319_2 - 1.7e-14 52.5 12.5 0.00031 20.5 0.0 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.4 T086319_2 - 3.5e-10 39.1 2.2 0.016 15.3 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.4 T086319_2 - 3.6e-10 39.7 7.4 0.27 12.0 0.1 7.0 4 1 4 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.4 T086319_2 - 4.3e-10 39.8 16.7 0.0015 18.9 0.0 6.3 4 2 1 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.4 T086319_2 - 2.9e-09 37.3 3.1 0.0078 16.8 0.1 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 T086319_2 - 1.9e-07 30.5 16.4 0.00063 19.3 0.0 7.2 9 0 0 9 9 9 2 Tetratricopeptide repeat ANAPC3 PF12895.5 T086319_2 - 6.2e-07 29.4 14.5 0.01 15.9 0.2 5.5 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.7 T086319_2 - 0.0003 20.5 1.7 0.0014 18.3 0.7 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat-like domain TPR_17 PF13431.4 T086319_2 - 0.00035 20.6 2.7 0.62 10.4 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.4 T086319_2 - 0.00071 19.1 8.7 0.16 11.6 0.0 5.7 5 1 1 6 6 6 1 TPR repeat TPR_7 PF13176.4 T086319_2 - 0.0015 18.3 7.3 1.9 8.6 0.0 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat ChAPs PF09295.8 T086319_2 - 0.0021 17.0 3.1 1.8 7.3 0.1 3.1 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_12 PF13424.4 T086319_2 - 0.039 14.1 11.9 0.78 9.9 0.3 6.2 6 2 1 7 7 6 0 Tetratricopeptide repeat TPR_6 PF13174.4 T086319_2 - 0.1 13.2 13.7 18 6.1 0.0 6.2 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_10 PF13374.4 T086319_2 - 0.16 11.8 0.9 0.74 9.7 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.4 T086319_2 - 0.31 11.3 2.0 14 5.9 0.3 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat NARP1 PF12569.6 T086319_2 - 2.4 6.8 7.2 20 3.8 0.2 3.6 2 1 2 4 4 4 0 NMDA receptor-regulated protein 1 Transglut_core PF01841.17 T115427_1 - 2.5e-18 66.4 0.5 4.1e-18 65.7 0.5 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_C PF00927.20 T115427_3 - 6.5e-50 167.6 0.1 4e-26 91.1 0.1 2.3 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain PDZ PF00595.22 T019475_1 - 2.3e-40 136.7 4.7 3.2e-13 49.7 0.5 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T019475_1 - 4.4e-21 74.8 7.0 2.1e-07 31.0 0.2 3.3 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.4 T019475_1 - 2.4e-05 24.2 4.0 0.016 15.1 0.0 3.4 3 0 0 3 3 3 2 Tricorn protease PDZ domain GRASP55_65 PF04495.12 T019475_1 - 4e-05 23.8 0.1 0.16 12.2 0.0 2.8 3 0 0 3 3 3 2 GRASP55/65 PDZ-like domain DUF4265 PF14085.4 T019475_1 - 0.04 13.7 2.2 1.8 8.4 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4265) PDZ PF00595.22 T019475_2 - 9.9e-12 44.9 0.0 1.7e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T019475_2 - 0.00044 20.4 0.1 0.00078 19.6 0.1 1.3 1 0 0 1 1 1 1 PDZ domain Neur_chan_LBD PF02931.21 T371648_2 - 6.7e-53 179.2 0.0 9.5e-53 178.7 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 T371648_2 - 1.8e-37 129.5 4.8 8.5e-33 114.3 1.4 2.3 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region HEAT PF02985.20 T220938_3 - 0.00016 21.4 3.1 0.023 14.8 0.5 2.7 2 0 0 2 2 2 2 HEAT repeat Ank_2 PF12796.5 T019412_2 - 6.2e-15 55.4 3.1 1.5e-06 28.6 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T019412_2 - 7.4e-13 48.3 1.7 7.3e-09 35.6 0.3 2.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 T019412_2 - 1.1e-11 44.4 1.1 2.8e-05 24.2 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 T019412_2 - 3.4e-08 33.7 0.6 0.01 16.2 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 T019412_2 - 4.5e-08 32.6 0.3 0.011 16.1 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Spc7 PF08317.9 T019412_2 - 0.00028 19.8 6.7 0.00028 19.8 6.7 4.3 3 1 1 4 4 4 2 Spc7 kinetochore protein Fib_alpha PF08702.8 T019412_2 - 0.01 15.9 16.0 0.37 10.8 0.3 4.4 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family Reo_sigmaC PF04582.10 T019412_2 - 0.2 10.9 6.6 3.3 6.9 0.2 3.2 1 1 3 4 4 4 0 Reovirus sigma C capsid protein DUF837 PF05769.9 T019412_2 - 0.25 11.2 27.0 0.3 10.9 11.0 3.8 2 2 1 3 3 3 0 Protein of unknown function (DUF837) Synaptobrevin PF00957.19 T019412_2 - 1.2 8.8 3.9 1.8 8.3 0.6 2.8 2 0 0 2 2 2 0 Synaptobrevin DUF972 PF06156.11 T019412_2 - 4.5 7.8 36.3 13 6.3 3.6 6.1 3 1 2 5 5 5 0 Protein of unknown function (DUF972) HALZ PF02183.16 T019412_2 - 7.3 6.7 20.4 0.021 14.9 6.4 3.8 3 0 0 3 3 3 0 Homeobox associated leucine zipper GIT_CC PF16559.3 T019412_2 - 8.9 6.3 17.8 3.8 7.5 0.7 4.1 4 0 0 4 4 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Ank_4 PF13637.4 T019412_3 - 8.6e-11 42.0 0.1 9.5e-07 29.1 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 T019412_3 - 9.2e-11 42.1 0.0 1.7e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T019412_3 - 5e-10 39.3 0.0 1.2e-09 38.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.28 T019412_3 - 2.4e-09 37.1 0.2 9.4e-05 22.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 T019412_3 - 3.1e-07 30.0 0.1 0.0028 17.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat ANF_receptor PF01094.26 T332575_1 - 1.4e-104 349.8 0.0 1.9e-104 349.4 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 T332575_1 - 3.1e-59 200.5 16.4 5.1e-59 199.8 16.4 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 T332575_1 - 3.2e-14 52.5 11.6 8.1e-14 51.2 11.6 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 T332575_1 - 1.5e-06 28.0 0.0 3.2e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein CAF1 PF04857.18 T291908_1 - 1.6e-21 76.7 0.9 1e-10 41.2 0.1 2.3 1 1 0 2 2 2 2 CAF1 family ribonuclease UPF0020 PF01170.16 T188077_1 - 1e-17 64.4 0.0 1.8e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.4 T188077_1 - 5.4e-09 36.5 0.0 9.4e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T188077_1 - 9.7e-09 35.1 0.0 1.6e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 T188077_1 - 2.2e-07 31.3 0.0 3.8e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 T188077_1 - 2.1e-05 24.0 0.0 3.2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.16 T188077_1 - 3.9e-05 23.0 0.0 6.4e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.10 T188077_1 - 0.0062 17.1 0.0 0.011 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain THUMP PF02926.15 T188077_3 - 0.08 12.9 0.0 0.08 12.9 0.0 2.1 3 0 0 3 3 3 0 THUMP domain LIF_OSM PF01291.15 T232024_1 - 8.9e-75 250.1 0.0 1.3e-74 249.6 0.0 1.3 1 0 0 1 1 1 1 LIF / OSM family RabGAP-TBC PF00566.16 T232024_3 - 2.8e-52 177.4 0.0 4.6e-52 176.7 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ACT_7 PF13840.4 T232024_3 - 7e-35 118.5 0.4 3.7e-16 58.5 0.9 2.4 2 0 0 2 2 2 2 ACT domain TTL PF03133.13 T237654_1 - 3.3e-84 282.4 0.0 4.9e-84 281.8 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.4 T237654_1 - 0.19 10.8 0.0 1.5 7.8 0.0 2.0 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp ARPC4 PF05856.10 T237654_3 - 4.6e-82 273.5 8.0 6e-82 273.1 8.0 1.1 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Sm_like PF16243.3 T237654_3 - 0.07 13.1 0.1 0.12 12.4 0.1 1.2 1 0 0 1 1 1 0 Sm_like domain DUF4200 PF13863.4 T086769_1 - 2.8e-27 95.3 17.7 2.8e-27 95.3 17.7 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4200) BCL_N PF04714.11 T086769_1 - 0.046 13.7 0.2 0.16 11.9 0.2 2.0 1 0 0 1 1 1 0 BCL7, N-terminal conserver region PilO PF04350.11 T086769_1 - 10 6.2 9.5 0.49 10.4 0.6 2.7 2 1 1 3 3 3 0 Pilus assembly protein, PilO CYYR1 PF10873.6 T224564_2 - 3.9e-80 267.4 13.8 6.3e-80 266.7 13.8 1.3 1 0 0 1 1 1 1 Cysteine and tyrosine-rich protein 1 Yip1 PF04893.15 T168380_1 - 1.3e-20 73.7 8.6 1.3e-20 73.7 8.6 1.8 2 1 0 2 2 2 1 Yip1 domain DUF2070 PF09843.7 T168380_1 - 1.5 6.9 3.8 2.1 6.4 3.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PDZ PF00595.22 T374631_3 - 2.4e-13 50.1 0.0 4.2e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T374631_3 - 0.05 13.8 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 PDZ domain HAP1_N PF04849.11 T147556_1 - 4e-96 321.7 21.7 6e-96 321.2 21.7 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region CDC45 PF02724.12 T147556_1 - 0.26 9.4 8.3 0.46 8.6 8.3 1.2 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_3_Rpc31 PF11705.6 T147556_1 - 0.93 9.5 9.6 1.8 8.6 9.6 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 BSP_II PF05432.9 T147556_1 - 9.9 5.6 15.0 15 5.0 15.0 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) VKOR PF07884.12 T325548_3 - 3.4e-28 98.2 8.0 8.5e-28 96.9 8.0 1.7 1 0 0 1 1 1 1 Vitamin K epoxide reductase family LRR_8 PF13855.4 T126497_1 - 2.4e-35 120.0 21.1 8.9e-15 54.1 2.3 5.4 2 2 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 T126497_1 - 5.4e-16 58.2 20.3 0.0025 18.0 0.0 5.5 3 2 3 7 7 7 6 Leucine Rich repeats (2 copies) EGF PF00008.25 T126497_1 - 3.3e-06 27.1 8.7 0.00018 21.6 7.7 3.4 2 0 0 2 2 2 1 EGF-like domain LRR_9 PF14580.4 T126497_1 - 8.3e-06 25.3 5.2 0.0018 17.7 1.8 3.0 2 1 1 3 3 3 2 Leucine-rich repeat fn3 PF00041.19 T126497_1 - 0.00024 21.3 0.0 0.00048 20.3 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain LRRNT PF01462.16 T126497_1 - 0.00036 20.0 3.3 0.00036 20.0 3.3 4.6 3 1 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 T126497_1 - 0.062 13.7 13.2 50 4.8 0.0 7.4 7 0 0 7 7 7 0 Leucine Rich Repeat hEGF PF12661.5 T126497_1 - 0.65 10.6 13.6 0.012 16.1 3.3 3.5 3 0 0 3 3 3 0 Human growth factor-like EGF DUF4554 PF15091.4 T061801_1 - 2e-269 894.0 0.6 2.6e-269 893.6 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4554) Abi PF02517.14 T061801_2 - 5.9e-15 55.3 3.7 1.3e-14 54.2 3.7 1.5 1 0 0 1 1 1 1 CAAX protease self-immunity CCDC74_C PF14917.4 T199072_2 - 8.8e-38 129.4 5.9 1.3e-37 128.8 5.9 1.2 1 0 0 1 1 1 1 Coiled coil protein 74, C terminal ADAM_spacer1 PF05986.12 T107067_1 - 4.3e-35 120.1 0.0 6.1e-35 119.6 0.0 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.17 T107067_1 - 8.2e-24 83.4 58.9 9.9e-10 38.4 12.7 5.8 5 0 0 5 5 5 4 Thrombospondin type 1 domain I-set PF07679.14 T107067_1 - 5.6e-18 64.7 0.0 6.5e-09 35.6 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 T107067_1 - 7.5e-17 61.6 0.3 4.8e-09 36.6 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T107067_1 - 1.4e-12 47.6 0.4 0.0011 18.9 0.0 4.2 3 1 0 3 3 3 3 Immunoglobulin V-set domain Ig_2 PF13895.4 T107067_1 - 7.6e-12 45.3 0.1 1.9e-05 24.8 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 T107067_1 - 2.1e-11 43.7 0.1 2.1e-06 27.7 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain PLAC PF08686.9 T107067_1 - 1.5e-10 41.4 7.1 1.5e-10 41.4 7.1 3.9 5 0 0 5 5 5 1 PLAC (protease and lacunin) domain I-set PF07679.14 T107067_3 - 1e-14 54.2 0.0 1.6e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T107067_3 - 1.5e-14 54.2 0.0 3e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T107067_3 - 1.6e-10 41.1 0.0 3.1e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T107067_3 - 1.6e-09 37.7 0.0 2.7e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 T107067_3 - 5.2e-06 26.5 0.0 0.0031 17.5 0.0 2.3 1 1 1 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 T107067_3 - 0.0039 17.1 0.0 0.0089 15.9 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Syntaxin-18_N PF10496.7 T241843_1 - 0.22 11.6 0.1 0.38 10.9 0.1 1.2 1 0 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus EF-hand_6 PF13405.4 T241843_2 - 2e-05 24.0 0.0 0.39 10.6 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 T241843_2 - 0.00071 18.8 1.2 0.19 11.2 0.0 3.5 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.4 T241843_2 - 0.043 14.2 0.0 0.09 13.1 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair Spy1 PF11357.6 T329540_1 - 3.6e-40 137.1 3.9 7e-25 87.7 0.1 2.2 1 1 1 2 2 2 2 Cell cycle regulatory protein RhoGEF PF00621.18 T105911_3 - 2e-44 151.8 0.6 3.2e-44 151.2 0.6 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 T105911_3 - 1.5e-07 31.7 0.2 3.4e-07 30.6 0.2 1.6 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 T105911_3 - 0.02 15.0 1.1 0.18 12.0 0.1 2.2 1 1 1 2 2 2 0 Pleckstrin homology domain PH_13 PF16652.3 T105911_3 - 0.095 12.5 0.2 0.18 11.6 0.2 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain DNA_pol_phi PF04931.11 T105911_3 - 1.8 6.4 7.5 2.7 5.9 7.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi RR_TM4-6 PF06459.10 T105911_3 - 8.9 5.9 8.8 17 5.0 8.8 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Yae1_N PF09811.7 T175849_1 - 0.42 10.2 6.3 0.7 9.5 6.3 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal TGFb_propeptide PF00688.16 T175849_2 - 3.3e-38 131.7 0.0 4.6e-38 131.2 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 T175849_2 - 3.9e-21 75.8 1.6 9.6e-21 74.5 1.6 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain B9-C2 PF07162.9 T175849_3 - 9.1e-59 198.3 0.1 1.5e-58 197.6 0.1 1.3 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Yae1_N PF09811.7 T175849_3 - 0.12 12.0 7.8 0.21 11.2 7.8 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal DUF1725 PF08333.9 T175849_3 - 0.13 11.8 1.3 0.25 10.9 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Sec1 PF00995.21 T167281_1 - 2.1e-122 410.1 0.0 7.3e-121 405.0 0.0 2.7 2 1 0 2 2 2 1 Sec1 family DUF2346 PF09803.7 T167281_1 - 4.4e-22 78.3 2.4 4.4e-22 78.3 2.4 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2346) RhoGAP PF00620.25 T113615_1 - 1.5e-32 112.4 0.1 2.4e-32 111.7 0.1 1.2 1 0 0 1 1 1 1 RhoGAP domain PhaG_MnhG_YufB PF03334.12 T259056_2 - 0.81 9.8 14.3 0.26 11.4 4.3 3.5 3 0 0 3 3 3 0 Na+/H+ antiporter subunit Tubulin PF00091.23 T370025_1 - 3.3e-67 226.4 0.0 4.5e-67 225.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 T370025_1 - 2e-41 141.1 0.1 2.9e-41 140.5 0.1 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Na_Pi_cotrans PF02690.13 T370025_1 - 6.8e-34 116.8 20.3 6.2e-19 68.4 7.9 2.3 2 0 0 2 2 2 2 Na+/Pi-cotransporter Misat_Tub_SegII PF10644.7 T370025_1 - 0.00031 20.9 0.0 0.00052 20.2 0.0 1.3 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain zf-RING_2 PF13639.4 T370025_1 - 0.00059 19.9 11.2 0.00059 19.9 11.2 2.9 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.4 T370025_1 - 0.011 15.6 13.3 0.006 16.4 8.6 3.0 3 0 0 3 3 3 0 RING-type zinc-finger zf-C3HC4_4 PF15227.4 T370025_1 - 0.026 14.5 8.9 0.07 13.2 8.9 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 T370025_1 - 0.062 13.1 12.8 0.018 14.7 8.9 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T370025_1 - 0.11 12.3 16.4 0.0028 17.4 8.6 2.7 2 0 0 2 2 2 0 zinc-RING finger domain Tubulin_3 PF14881.4 T370025_1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Tubulin domain DUF2477 PF10631.7 T370025_2 - 2.2e-76 255.1 28.7 2.2e-76 255.1 28.7 3.2 4 0 0 4 4 4 1 Protein of unknown function (DUF2477) Ig_3 PF13927.4 T246075_1 - 1.2e-30 105.8 0.4 3.5e-11 43.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T246075_1 - 1.4e-26 92.3 0.0 1.3e-09 37.8 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 T246075_1 - 1.6e-25 89.0 0.3 5.4e-07 29.5 0.2 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T246075_1 - 4.4e-23 81.3 0.1 6.4e-08 32.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.10 T246075_1 - 1e-14 54.2 0.0 1e-13 51.0 0.0 2.4 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 T246075_1 - 4.7e-13 49.1 1.5 2.4e-08 34.0 0.2 3.6 3 1 0 3 3 3 2 Immunoglobulin V-set domain C1-set PF07654.13 T246075_1 - 3.3e-08 33.7 0.0 9.2e-07 29.1 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Myosin_head PF00063.19 T139389_2 - 1e-245 817.0 0.0 1.3e-245 816.7 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 T139389_2 - 2.5e-30 105.4 0.0 4e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 T139389_2 - 1e-06 27.8 16.7 0.0017 17.8 1.7 3.8 3 0 0 3 3 3 2 IQ calmodulin-binding motif AAA_16 PF13191.4 T139389_2 - 0.11 12.7 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 T139389_2 - 0.14 12.3 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain SH3_2 PF07653.15 T139389_3 - 1e-21 76.2 0.4 4.6e-10 38.9 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.22 T139389_3 - 1.7e-17 63.1 0.0 3.2e-17 62.2 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 T139389_3 - 2.5e-16 58.9 0.6 6.8e-14 51.1 0.2 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 T139389_3 - 2.6e-11 43.0 0.1 2.7e-08 33.4 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain malic PF00390.17 T065306_1 - 5.6e-79 264.0 0.0 8.4e-79 263.5 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.13 T065306_2 - 1.9e-100 335.3 0.1 2.4e-100 334.9 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain Palm_thioest PF02089.13 T301456_2 - 3e-14 52.7 0.0 4.7e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.18 T301456_2 - 1.5e-05 24.6 0.1 2.7e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.12 T301456_2 - 0.0058 16.0 0.0 0.012 15.0 0.0 1.4 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.11 T301456_2 - 0.053 13.1 0.0 0.11 12.0 0.0 1.4 2 0 0 2 2 2 0 PGAP1-like protein EMI PF07546.11 T301456_3 - 1.8e-16 60.5 10.2 1.8e-16 60.5 10.2 2.5 2 0 0 2 2 2 1 EMI domain EGF_CA PF07645.13 T301456_3 - 3.5e-06 27.0 5.0 3.5e-06 27.0 5.0 3.1 2 0 0 2 2 2 1 Calcium-binding EGF domain FXa_inhibition PF14670.4 T301456_3 - 1.2e-05 25.4 7.4 1.2e-05 25.4 7.4 3.2 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site EGF PF00008.25 T301456_3 - 0.00043 20.4 7.0 0.00043 20.4 7.0 3.6 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.5 T301456_3 - 0.0094 16.5 5.6 0.0094 16.5 5.6 3.8 2 0 0 2 2 2 1 Human growth factor-like EGF G6B PF15096.4 T301127_1 - 1.4e-24 86.9 0.0 2.2e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 G6B family G6B PF15096.4 T301127_2 - 3.1e-40 138.1 3.3 4.8e-40 137.6 3.3 1.2 1 0 0 1 1 1 1 G6B family G6B PF15096.4 T301127_3 - 1.6e-12 47.6 0.1 2.8e-12 46.7 0.1 1.3 1 0 0 1 1 1 1 G6B family SEFIR PF08357.9 T309679_3 - 1.4e-35 122.6 0.3 2.7e-35 121.7 0.3 1.5 1 0 0 1 1 1 1 SEFIR domain TIR_2 PF13676.4 T309679_3 - 0.0006 20.0 0.0 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 TIR domain Humanin PF15040.4 T061024_1 - 0.4 10.1 2.0 0.84 9.1 2.0 1.5 1 0 0 1 1 1 0 Humanin family Img2 PF05046.12 T061024_3 - 3.1e-27 94.6 0.0 4.5e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) DnaJ_C PF01556.16 T120284_1 - 2.9e-31 108.4 1.2 3.9e-31 108.0 1.2 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.17 T120284_1 - 8.2e-15 54.8 17.4 1.4e-14 54.0 17.4 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.3 T120284_1 - 0.011 15.6 9.8 0.3 10.9 2.2 2.5 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.17 T120284_1 - 0.43 10.5 7.3 3.4 7.6 0.4 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_10 PF16685.3 T120284_1 - 2.4 8.2 9.7 0.42 10.7 1.0 2.6 1 1 1 2 2 2 0 zinc RING finger of MSL2 DnaJ_C PF01556.16 T120284_2 - 0.00014 21.9 0.0 0.0002 21.4 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DEAD PF00270.27 T354307_1 - 5e-16 58.8 0.0 6.8e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T354307_1 - 0.00086 19.5 0.0 0.22 11.8 0.0 2.3 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.13 T354307_1 - 0.019 14.9 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Drc1-Sld2 PF11719.6 T354307_2 - 2.3e-08 33.9 0.0 3.2e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 DNA replication and checkpoint protein Helicase_C PF00271.29 T354307_2 - 5.5e-08 33.0 0.0 9.5e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AA_permease PF00324.19 T329900_1 - 9.7e-22 77.1 15.7 1.3e-21 76.6 15.7 1.1 1 0 0 1 1 1 1 Amino acid permease ARS2 PF04959.11 T329900_2 - 2.7e-90 301.9 1.2 5.7e-90 300.8 1.2 1.6 1 0 0 1 1 1 1 Arsenite-resistance protein 2 AA_permease PF00324.19 T329900_2 - 6.1e-90 302.0 8.7 8.2e-90 301.5 8.7 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3546 PF12066.6 T329900_2 - 1.6e-40 137.7 0.4 3.6e-40 136.5 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) SLC12 PF03522.13 T329900_2 - 6.4e-18 64.8 10.0 3.9e-10 39.2 0.0 4.2 4 0 0 4 4 4 3 Solute carrier family 12 RRM_1 PF00076.20 T329900_2 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.7 T329900_2 - 0.86 8.0 6.7 1.3 7.4 6.7 1.1 1 0 0 1 1 1 0 Transmembrane protein LIM PF00412.20 T329900_3 - 1.2e-27 95.8 26.2 4e-12 46.1 1.4 3.9 4 0 0 4 4 4 3 LIM domain Ank_2 PF12796.5 T177253_2 - 4.5e-15 55.9 1.3 4.6e-11 43.0 0.2 1.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) SH3_9 PF14604.4 T177253_2 - 1.5e-11 43.8 0.7 2.9e-11 42.9 0.7 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.28 T177253_2 - 6.9e-10 38.8 2.4 0.00055 20.1 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeat SH3_1 PF00018.26 T177253_2 - 1.2e-09 37.5 0.5 1.9e-09 36.8 0.5 1.4 1 0 0 1 1 1 1 SH3 domain Ank_3 PF13606.4 T177253_2 - 1.2e-08 34.3 1.0 0.0072 16.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 T177253_2 - 3.7e-08 33.4 1.6 9.5e-05 22.5 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_2 PF07653.15 T177253_2 - 1.6e-07 30.8 0.0 3.1e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Ank_4 PF13637.4 T177253_2 - 1.9e-07 31.3 0.2 4.7e-05 23.7 0.7 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) zf-C2H2 PF00096.24 T139530_1 - 1.4e-22 78.7 22.9 2.7e-05 24.3 1.7 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type BTB PF00651.29 T139530_1 - 2e-22 79.4 0.0 2.9e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 T139530_1 - 9.9e-21 72.5 18.9 0.00048 20.6 0.6 6.0 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T139530_1 - 3.6e-16 58.6 25.2 5.8e-07 29.5 0.1 6.2 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_jaz PF12171.6 T139530_1 - 1.8e-12 47.1 1.9 0.0022 18.1 0.2 5.3 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T139530_1 - 5.2e-09 35.7 14.5 0.058 13.2 0.2 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger zf-met PF12874.5 T139530_1 - 8.9e-08 32.2 14.3 0.025 14.8 0.4 5.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 T139530_1 - 0.0015 18.1 15.2 0.45 10.2 0.3 4.9 5 0 0 5 5 5 2 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 T139530_1 - 0.0022 18.2 11.1 1.4 9.1 6.5 4.6 2 1 1 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.10 T139530_1 - 0.028 14.5 10.3 0.37 11.0 0.6 3.1 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-UBP PF02148.17 T139530_1 - 0.27 11.4 5.0 10 6.4 0.0 3.3 2 1 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein LIM PF00412.20 T139530_1 - 0.75 9.9 5.5 0.65 10.1 0.3 2.7 1 1 2 3 3 3 0 LIM domain Zn-ribbon_8 PF09723.8 T139530_1 - 2.9 8.0 14.4 0.52 10.3 1.3 3.6 3 1 1 4 4 4 0 Zinc ribbon domain SprT-like PF10263.7 T139530_1 - 5.8 6.6 9.5 7.5 6.2 1.0 2.5 1 1 0 2 2 2 0 SprT-like family zf-AN1 PF01428.14 T139530_1 - 8 6.6 8.3 78 3.4 0.1 4.2 4 0 0 4 4 4 0 AN1-like Zinc finger FGGY_C PF02782.14 T240351_1 - 3.9e-17 62.5 0.0 6.7e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.19 T240351_1 - 8.2e-16 58.2 0.0 3e-14 53.1 0.0 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain GP41 PF00517.15 T240351_3 - 3.2e-14 53.1 1.7 5.9e-14 52.2 1.7 1.3 1 0 0 1 1 1 1 Retroviral envelope protein Connexin PF00029.17 T032149_2 - 2.4e-95 318.5 0.0 3.7e-95 317.8 0.0 1.3 1 0 0 1 1 1 1 Connexin Guanylate_kin PF00625.19 T032149_2 - 5.1e-67 224.9 0.0 6.9e-67 224.5 0.0 1.2 1 0 0 1 1 1 1 Guanylate kinase GCV_T_C PF08669.9 T032149_2 - 1.8e-06 27.9 0.0 4.1e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain AAA_18 PF13238.4 T032149_2 - 0.00055 20.3 0.0 0.0009 19.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 T032149_2 - 0.00061 19.8 0.1 0.0015 18.6 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 T032149_2 - 0.00099 19.4 0.0 0.0022 18.3 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain GCV_T PF01571.19 T032149_2 - 0.013 14.7 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain DUF258 PF03193.14 T032149_2 - 0.023 14.5 0.1 0.041 13.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.25 T032149_2 - 0.027 14.8 0.0 0.049 14.0 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.4 T032149_2 - 0.036 14.2 0.0 0.064 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.21 T032149_2 - 0.057 13.4 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF1725 PF08333.9 T032149_2 - 0.059 12.9 1.3 0.12 11.9 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) AAA_29 PF13555.4 T032149_2 - 0.14 11.8 0.1 0.27 10.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.17 T032149_2 - 0.2 11.1 0.1 0.34 10.3 0.1 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain CARD PF00619.19 T134276_2 - 5.5e-17 61.4 0.0 8.6e-17 60.8 0.0 1.3 1 0 0 1 1 1 1 Caspase recruitment domain F-box-like PF12937.5 T134276_2 - 1.7e-09 37.3 0.1 3.8e-09 36.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T134276_2 - 1.6e-06 27.7 0.0 5.2e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 F-box domain HSF_DNA-bind PF00447.15 T134276_3 - 6.8e-23 81.0 0.2 1.1e-22 80.2 0.2 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding GCN5L1 PF06320.11 T079952_1 - 1.8e-46 156.8 6.1 3.5e-46 155.9 6.1 1.5 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) adh_short PF00106.23 T079952_1 - 6.8e-36 123.4 0.0 1.2e-35 122.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 T079952_1 - 3.7e-26 92.0 0.0 6.2e-26 91.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 T079952_1 - 0.028 14.2 0.0 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 KR domain DUF1776 PF08643.8 T079952_1 - 0.16 11.1 0.0 0.59 9.3 0.0 1.8 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) GSCFA PF08885.9 T079952_1 - 0.21 11.1 0.1 0.4 10.2 0.1 1.3 1 0 0 1 1 1 0 GSCFA family DUF1725 PF08333.9 T086870_2 - 5.2e-05 22.6 0.7 0.00011 21.6 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RRM_1 PF00076.20 T086870_3 - 7.2e-84 275.5 8.0 1.5e-18 66.2 0.2 6.3 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T086870_3 - 0.00028 20.8 0.2 16 5.6 0.0 4.5 4 0 0 4 4 4 1 RNA recognition motif RRM_3 PF08777.9 T086870_3 - 0.00042 20.2 0.4 1.7 8.6 0.1 4.8 5 0 0 5 5 5 1 RNA binding motif Limkain-b1 PF11608.6 T086870_3 - 0.023 14.6 0.0 2.2 8.3 0.0 3.0 3 0 0 3 3 3 0 Limkain b1 DnaJ-X PF14308.4 T086870_3 - 0.043 13.1 0.1 0.077 12.3 0.1 1.3 1 0 0 1 1 1 0 X-domain of DnaJ-containing Ion_trans PF00520.29 T071639_1 - 9.2e-248 817.4 80.5 9.3e-71 237.8 18.5 4.3 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 T071639_1 - 4.8e-37 128.4 12.3 7.2e-27 94.9 0.0 3.0 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 T071639_1 - 5.8e-36 122.0 0.0 1.2e-35 121.0 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 T071639_1 - 5.5e-30 103.3 0.1 1.1e-29 102.4 0.1 1.5 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 T071639_1 - 1.4e-09 37.0 31.7 1.1e-08 34.1 8.8 7.6 7 1 0 7 7 7 3 Polycystin cation channel DUF3402 PF11882.6 T017031_3 - 1e-104 351.1 18.6 1.3e-66 225.5 4.9 3.3 1 1 2 3 3 3 3 Domain of unknown function (DUF3402) N1221 PF07923.11 T017031_3 - 9.4e-52 175.9 0.0 1.5e-51 175.2 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein ELM2 PF01448.22 T017031_3 - 0.12 13.1 0.5 0.34 11.6 0.5 1.8 1 0 0 1 1 1 0 ELM2 domain SR-25 PF10500.7 T088258_3 - 7.2e-96 320.0 50.0 1.1e-95 319.4 50.0 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.7 T088258_3 - 0.042 12.3 19.9 0.065 11.7 19.9 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF1777 PF08648.10 T088258_3 - 4.7 7.3 38.2 8.5 6.5 38.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) 7tm_4 PF13853.4 T358025_2 - 1.4e-55 188.9 13.7 2.1e-55 188.3 13.7 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T358025_2 - 9e-25 87.3 13.2 1.3e-24 86.7 13.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Miff PF05644.9 T209051_2 - 1.2e-106 356.5 1.0 1.6e-106 356.1 1.0 1.1 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff RelB_transactiv PF16181.3 T177153_1 - 5.1e-97 323.1 9.9 5.1e-97 323.1 9.9 1.7 2 0 0 2 2 2 1 RelB transactivation domain RHD_DNA_bind PF00554.20 T177153_1 - 1.3e-62 210.6 0.1 1.3e-62 210.6 0.1 1.6 2 0 0 2 2 2 1 Rel homology DNA-binding domain DRY_EERY PF09750.7 T177153_1 - 4.8e-42 143.3 0.0 4.8e-42 143.3 0.0 2.9 3 0 0 3 3 3 1 Alternative splicing regulator RHD_dimer PF16179.3 T177153_1 - 9.7e-37 125.0 0.0 2e-36 124.0 0.0 1.5 1 0 0 1 1 1 1 Rel homology dimerisation domain RelB_leu_zip PF16180.3 T177153_1 - 8.8e-18 64.2 0.3 2.5e-17 62.8 0.3 1.7 1 0 0 1 1 1 1 RelB leucine zipper Mod_r PF07200.11 T339635_1 - 2.2e-38 131.5 15.7 4.2e-38 130.6 15.7 1.5 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein UEV PF05743.11 T339635_1 - 0.013 15.3 1.4 0.033 13.9 1.2 1.8 2 0 0 2 2 2 0 UEV domain CD20 PF04103.13 T100620_2 - 0.0074 16.3 3.5 0.0074 16.3 3.5 1.9 1 1 1 2 2 2 1 CD20-like family CH_2 PF06294.9 T280934_1 - 3.4e-22 78.3 0.4 1.2e-21 76.5 0.0 2.2 2 0 0 2 2 2 1 CH-like domain in sperm protein ADK PF00406.20 T280934_1 - 1.8e-08 34.5 0.1 1.8e-08 34.5 0.1 4.4 4 2 0 4 4 4 1 Adenylate kinase AAA_17 PF13207.4 T280934_1 - 0.011 16.1 0.0 0.052 13.8 0.0 4.1 3 2 1 4 4 4 0 AAA domain Hydin_ADK PF17213.1 T280934_1 - 0.033 14.4 8.6 0.044 13.9 0.0 3.7 3 1 0 3 3 3 0 Hydin Adenylate kinase-like domain DUF1749 PF08538.8 T280934_1 - 2.8 6.9 4.8 1.5 7.7 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) SH3_1 PF00018.26 T143526_1 - 4.7e-16 58.0 0.1 1.4e-15 56.5 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH2 PF00017.22 T143526_1 - 1.3e-12 47.5 0.1 2.1e-12 46.8 0.1 1.3 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.4 T143526_1 - 4.2e-11 42.4 0.0 9.1e-11 41.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T143526_1 - 2.8e-08 33.2 0.0 1.3e-07 31.0 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.9 T143526_1 - 0.082 13.1 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain SH3_2 PF07653.15 T143526_3 - 4.4e-15 55.0 0.0 8.8e-15 54.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T143526_3 - 6.6e-15 54.3 0.0 1.1e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T143526_3 - 1.4e-13 50.4 0.0 3.3e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH2 PF00017.22 T143526_3 - 0.00012 22.0 0.0 0.00019 21.3 0.0 1.3 1 0 0 1 1 1 1 SH2 domain Metallopep PF12044.6 T143526_3 - 0.49 8.8 1.1 0.74 8.2 1.1 1.2 1 0 0 1 1 1 0 Putative peptidase family LIP1 PF15904.3 T208259_2 - 8e-43 144.6 0.8 2.3e-42 143.1 0.8 1.8 1 0 0 1 1 1 1 LKB1 serine/threonine kinase interacting protein 1 LRR_8 PF13855.4 T208259_2 - 4.4e-09 35.8 18.7 1.8e-05 24.3 2.7 4.2 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 T208259_2 - 4.1e-08 33.2 19.5 0.00015 21.9 0.4 5.0 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 T208259_2 - 0.00061 19.8 12.3 12 6.8 0.5 6.5 5 1 0 5 5 5 1 Leucine Rich Repeat Zn-ribbon_8 PF09723.8 T208259_2 - 0.0014 18.5 0.8 0.0062 16.5 0.8 2.1 1 0 0 1 1 1 1 Zinc ribbon domain HypA PF01155.17 T208259_2 - 0.076 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA LRR_9 PF14580.4 T208259_2 - 0.12 11.7 0.1 0.63 9.4 0.0 1.8 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.4 T208259_2 - 0.18 11.8 8.0 14 5.9 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich repeat Ribosomal_L6e PF01159.17 T208259_2 - 0.28 11.5 2.8 0.48 10.8 2.8 1.3 1 0 0 1 1 1 0 Ribosomal protein L6e DUF4637 PF15470.4 T208259_2 - 2.7 7.7 10.4 4.8 6.8 10.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CDC45 PF02724.12 T208259_2 - 8.6 4.4 5.0 15 3.6 5.0 1.3 1 0 0 1 1 1 0 CDC45-like protein RhoGEF PF00621.18 T141418_3 - 7.2e-32 111.0 0.1 1e-31 110.5 0.1 1.2 1 0 0 1 1 1 1 RhoGEF domain Dynamin_M PF01031.18 T025137_1 - 5.8e-105 350.5 4.5 5.8e-105 350.5 4.5 1.6 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.21 T025137_1 - 2e-43 148.2 0.0 4.3e-43 147.1 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.16 T025137_1 - 5.9e-28 96.7 3.7 1.1e-27 95.8 3.7 1.5 1 0 0 1 1 1 1 Dynamin GTPase effector domain PH PF00169.27 T025137_1 - 3.2e-12 46.8 0.4 5.8e-12 45.9 0.4 1.4 1 0 0 1 1 1 1 PH domain Pkinase PF00069.23 T175494_2 - 1.8e-76 256.9 0.0 2.4e-76 256.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T175494_2 - 1e-35 123.2 0.0 1.4e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Cyclin_N PF00134.21 T175494_2 - 4.5e-19 68.4 0.0 7.8e-19 67.6 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain PH PF00169.27 T175494_2 - 1.8e-16 60.4 0.0 2.9e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.4 T175494_2 - 1.9e-08 33.9 0.0 3.8e-08 32.9 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.22 T175494_2 - 1.6e-07 31.8 0.8 3.1e-07 30.8 0.8 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Cyclin_C PF02984.17 T175494_2 - 0.00082 19.3 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Cyclin, C-terminal domain S_100 PF01023.17 T021084_2 - 5.4e-15 54.7 0.2 9.9e-15 53.9 0.2 1.5 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 T021084_2 - 0.003 17.9 0.3 0.0054 17.0 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair Thymosin PF01290.18 T021084_3 - 0.26 10.9 0.8 0.5 10.0 0.8 1.4 1 0 0 1 1 1 0 Thymosin beta-4 family DUF1211 PF06736.9 T259147_2 - 6.4e-44 148.2 6.1 9.9e-23 80.3 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF1211) Ig_3 PF13927.4 T179912_3 - 0.00031 21.1 0.0 0.00062 20.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T179912_3 - 0.0018 18.3 0.0 0.0032 17.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T179912_3 - 0.097 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain ATP12 PF07542.9 T143136_2 - 7.4e-39 132.6 0.3 1.2e-38 132.0 0.3 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein THRAP3_BCLAF1 PF15440.4 T008026_2 - 1.5e-208 694.9 106.6 1.5e-208 694.9 106.6 3.4 3 0 0 3 3 3 1 THRAP3/BCLAF1 family SH3_9 PF14604.4 T008026_3 - 2.6e-34 116.7 1.3 2.4e-14 52.8 0.2 3.7 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.15 T008026_3 - 6.4e-29 99.3 0.1 8e-15 54.1 0.1 3.1 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.26 T008026_3 - 2.7e-27 94.0 4.2 6e-14 51.3 0.0 3.8 4 0 0 4 4 4 3 SH3 domain Fra10Ac1 PF09725.7 T046314_3 - 3.3e-51 172.4 7.1 6e-51 171.6 7.1 1.4 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 RimK PF08443.9 T073267_2 - 2.7e-39 134.6 0.0 4.3e-39 133.9 0.0 1.2 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.14 T073267_2 - 9.2e-11 41.3 0.0 1.5e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.12 T073267_2 - 2.5e-06 27.5 0.0 3.8e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.4 T073267_2 - 6.9e-05 22.1 1.6 0.1 11.7 0.3 3.1 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_Ter PF15632.4 T073267_2 - 0.0048 15.5 0.0 0.0073 14.9 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATPgrasp_YheCD PF14398.4 T073267_2 - 0.016 14.4 0.0 1.1 8.3 0.0 2.6 1 1 0 1 1 1 0 YheC/D like ATP-grasp bZIP_1 PF00170.19 T234019_1 - 2.4e-16 59.4 15.5 4.2e-16 58.6 15.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor Complex1_LYR PF05347.13 T234019_1 - 1.9e-10 40.5 4.3 3.6e-10 39.6 4.3 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) bZIP_2 PF07716.13 T234019_1 - 7.1e-06 25.9 14.5 1.4e-05 24.9 14.5 1.5 1 0 0 1 1 1 1 Basic region leucine zipper Complex1_LYR_2 PF13233.4 T234019_1 - 0.00045 20.8 1.6 0.0013 19.3 1.6 1.7 1 0 0 1 1 1 1 Complex1_LYR-like DUF3450 PF11932.6 T234019_1 - 0.0091 15.2 2.3 0.015 14.5 2.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) IncA PF04156.12 T234019_1 - 0.091 12.4 2.2 0.16 11.6 2.2 1.3 1 0 0 1 1 1 0 IncA protein Complex1_LYR_1 PF13232.4 T234019_1 - 0.21 12.1 1.0 0.47 11.0 1.0 1.5 1 0 0 1 1 1 0 Complex1_LYR-like Fez1 PF06818.13 T234019_1 - 0.34 11.2 7.5 0.57 10.5 7.5 1.2 1 0 0 1 1 1 0 Fez1 DUF4407 PF14362.4 T234019_1 - 0.81 8.9 4.5 1.3 8.2 4.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Taxilin PF09728.7 T234019_1 - 1.1 8.3 13.0 1.8 7.6 13.0 1.1 1 0 0 1 1 1 0 Myosin-like coiled-coil protein DivIC PF04977.13 T234019_1 - 3.6 7.3 6.6 8.3 6.1 6.6 1.6 1 0 0 1 1 1 0 Septum formation initiator Nop53 PF07767.9 T234019_1 - 4.6 6.4 13.2 7 5.8 13.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) bZIP_Maf PF03131.15 T234019_1 - 5 7.6 8.6 12 6.3 8.6 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor Laminin_II PF06009.10 T234019_1 - 5.9 6.8 6.0 9.6 6.1 6.0 1.3 1 0 0 1 1 1 0 Laminin Domain II AAA_13 PF13166.4 T234019_1 - 9.6 4.6 9.8 12 4.2 9.8 1.0 1 0 0 1 1 1 0 AAA domain Mab-21 PF03281.12 T234019_3 - 1.9e-16 60.1 0.0 1.1e-15 57.6 0.0 1.9 1 1 0 1 1 1 1 Mab-21 protein SOUL PF04832.10 T312328_2 - 2e-43 148.4 0.0 2.7e-43 147.9 0.0 1.2 1 0 0 1 1 1 1 SOUL heme-binding protein RVT_1 PF00078.25 T336772_3 - 0.0023 17.3 1.6 0.012 15.0 1.6 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.30 T087970_1 - 3.3e-14 52.9 4.4 5.4e-05 23.7 0.3 7.3 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T087970_1 - 0.0041 17.2 0.0 0.03 14.5 0.0 2.4 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PDZ_2 PF13180.4 T087970_2 - 8.8e-08 32.2 0.0 1.5e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.22 T087970_2 - 0.0008 19.6 0.1 0.0014 18.8 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) GRASP55_65 PF04495.12 T087970_2 - 0.014 15.6 0.0 0.023 14.9 0.0 1.2 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain zf-H2C2_2 PF13465.4 T267127_1 - 0.0015 18.8 11.8 0.0037 17.5 1.1 4.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.4 T267127_1 - 0.0021 18.6 3.2 0.0021 18.6 3.2 5.3 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2 PF00096.24 T267127_1 - 0.0028 17.9 31.8 0.0041 17.4 4.6 4.8 4 0 0 4 4 4 2 Zinc finger, C2H2 type K_channel_TID PF07941.9 T267127_1 - 0.092 13.1 0.2 0.092 13.1 0.2 6.4 7 0 0 7 7 7 0 Potassium channel Kv1.4 tandem inactivation domain zf-C2H2_9 PF16293.3 T267127_1 - 0.41 10.4 5.1 0.66 9.7 0.6 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.5 T267127_1 - 1.3 9.3 13.3 0.53 10.5 1.3 2.7 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.4 T267127_1 - 1.3 9.0 16.4 0.11 12.3 2.4 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger CpXC PF14353.4 T267127_1 - 2.4 8.1 6.1 2.3 8.1 0.1 2.7 2 1 0 2 2 2 0 CpXC protein zf-C2H2_jaz PF12171.6 T267127_1 - 4.3 7.6 9.9 2.9 8.2 1.3 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.13 T267127_1 - 4.4 7.3 7.7 5.1 7.1 0.5 2.9 2 0 0 2 2 2 0 BED zinc finger SET PF00856.26 T267127_2 - 0.027 14.7 0.0 0.062 13.6 0.0 1.6 1 1 0 1 1 1 0 SET domain UPA PF17217.1 T341782_3 - 8.5e-62 207.2 0.8 8.5e-62 207.2 0.8 1.8 2 0 0 2 2 2 1 UPA domain ZU5 PF00791.18 T341782_3 - 5.9e-30 103.4 0.0 1.1e-29 102.5 0.0 1.4 1 0 0 1 1 1 1 ZU5 domain Death PF00531.20 T341782_3 - 3.2e-13 49.5 0.1 6.6e-13 48.5 0.1 1.5 1 0 0 1 1 1 1 Death domain I-set PF07679.14 T341782_3 - 5.6e-12 45.4 0.0 1.4e-11 44.1 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin I-set domain TSP_1 PF00090.17 T341782_3 - 3.1e-11 43.2 24.7 1.6e-07 31.3 10.2 2.9 2 0 0 2 2 2 2 Thrombospondin type 1 domain Ig_3 PF13927.4 T341782_3 - 3.2e-11 43.5 0.0 1.4e-09 38.3 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 T341782_3 - 4.7e-08 33.0 0.0 2.1e-07 30.8 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 T341782_3 - 1.7e-07 31.3 0.0 5.1e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T289641_1 - 3.1e-38 129.6 0.0 8.2e-19 67.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 T289641_1 - 3.9e-27 94.5 0.0 1.3e-13 51.2 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 T289641_1 - 4.6e-15 55.4 0.0 1.1e-06 28.6 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 T289641_1 - 2.1e-14 53.5 0.0 3.2e-06 27.3 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 T289641_1 - 3e-07 30.4 2.0 0.002 18.1 0.4 3.7 3 1 0 3 3 3 2 Immunoglobulin V-set domain BiPBP_C PF06832.10 T289641_1 - 0.012 15.5 0.0 0.28 11.1 0.0 2.8 3 0 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family C2-set_2 PF08205.10 T289641_1 - 0.023 14.6 0.0 0.29 11.1 0.0 2.4 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain PTH2 PF01981.14 T151598_2 - 2.9e-47 159.6 0.1 4e-47 159.1 0.1 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 HTH_Tnp_Tc5 PF03221.14 T151598_3 - 2.8e-14 52.8 2.0 2.8e-14 52.7 0.3 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.11 T151598_3 - 2.9e-08 33.1 0.3 5.4e-08 32.2 0.3 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_1 PF01527.18 T151598_3 - 0.0016 18.5 0.1 0.0055 16.9 0.1 1.9 2 0 0 2 2 2 1 Transposase HTH_Tnp_ISL3 PF13542.4 T151598_3 - 0.0024 17.1 0.0 0.0061 15.8 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_38 PF13936.4 T151598_3 - 0.016 14.8 0.1 0.049 13.3 0.1 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_28 PF13518.4 T151598_3 - 0.018 15.0 0.0 0.056 13.4 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.4 T151598_3 - 0.047 13.4 0.1 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 Homeodomain-like domain Cro PF09048.8 T151598_3 - 2.3 8.2 5.0 28 4.7 0.1 3.3 3 0 0 3 3 3 0 Cro DZF PF07528.12 T168341_3 - 3e-108 361.0 0.0 4.1e-108 360.5 0.0 1.2 1 0 0 1 1 1 1 DZF domain dsrm PF00035.24 T168341_3 - 3.1e-24 85.3 0.1 2.2e-12 47.4 0.1 2.5 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.5 T168341_3 - 0.011 15.8 0.1 3.4 7.9 0.0 3.0 2 0 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 BSP_II PF05432.9 T168341_3 - 0.091 12.3 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) LRR_9 PF14580.4 T044424_3 - 1e-11 44.5 0.3 2.1e-11 43.5 0.3 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 T044424_3 - 2.5e-05 24.4 11.3 5.1e-05 23.4 6.0 3.3 1 1 2 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T044424_3 - 0.38 10.4 9.2 0.16 11.6 6.1 2.1 2 1 0 2 2 2 0 Leucine rich repeat 4F5 PF04419.12 T283809_1 - 5.4e-10 39.9 11.8 8.8e-10 39.2 11.8 1.3 1 0 0 1 1 1 1 4F5 protein family TOM_sub5 PF15178.4 T283809_2 - 2.3e-22 78.6 0.6 3.5e-22 78.0 0.6 1.3 1 0 0 1 1 1 1 Mitochondrial import receptor subunit TOM5 homolog Pou PF00157.15 T078564_1 - 1.7e-29 101.5 0.1 3.3e-29 100.6 0.1 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 T078564_1 - 2.9e-18 65.3 0.8 5.8e-18 64.3 0.8 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 T078564_1 - 0.011 15.5 0.0 0.027 14.3 0.0 1.5 1 0 0 1 1 1 0 Homeobox KN domain RD3 PF14473.4 T111229_3 - 8.4e-50 167.9 0.4 1.4e-49 167.2 0.4 1.3 1 0 0 1 1 1 1 RD3 protein Aa_trans PF01490.16 T077390_3 - 7.8e-49 166.3 27.0 1.2e-48 165.7 27.0 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CATSPERD PF15020.4 T034312_3 - 1.7e-29 102.5 0.8 2.3e-29 102.1 0.8 1.1 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit delta SEA PF01390.18 T329969_2 - 6.1e-10 39.2 0.8 1.3e-09 38.2 0.8 1.5 1 0 0 1 1 1 1 SEA domain EGF PF00008.25 T329969_2 - 2.7 8.2 16.3 7 6.9 1.9 2.9 2 0 0 2 2 2 0 EGF-like domain SEA PF01390.18 T329969_3 - 5e-13 49.1 0.2 1.7e-12 47.4 0.2 1.9 1 0 0 1 1 1 1 SEA domain VPS9 PF02204.16 T366512_2 - 2.4e-28 98.2 0.0 4.5e-28 97.4 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Glyco_hydro_59 PF02057.13 T108597_3 - 0 1632.1 11.8 0 1631.8 11.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 MHC_I PF00129.16 T178814_2 - 2.2e-42 144.5 0.0 4.2e-42 143.6 0.0 1.4 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 EF-hand_1 PF00036.30 T178814_2 - 2.1e-14 51.8 0.1 0.011 15.1 0.0 6.1 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.4 T178814_2 - 7.9e-14 51.8 2.7 0.00065 20.0 0.5 3.7 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.4 T178814_2 - 3.2e-13 48.3 0.9 0.15 11.9 0.0 6.5 6 0 0 6 6 6 3 EF-hand domain EF-hand_5 PF13202.4 T178814_2 - 1.8e-08 33.4 10.1 0.4 10.2 0.1 6.2 6 0 0 6 6 6 3 EF hand C1-set PF07654.13 T178814_2 - 3.9e-08 33.5 0.0 7.5e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain EF-hand_8 PF13833.4 T178814_2 - 5.1e-07 29.2 2.9 0.042 13.5 0.0 4.4 5 0 0 5 5 5 2 EF-hand domain pair MHC_I_3 PF16497.3 T178814_2 - 0.0013 18.1 0.0 0.0022 17.4 0.0 1.3 1 0 0 1 1 1 1 MHC-I family domain WD40 PF00400.30 T316111_1 - 8.2e-14 51.7 0.8 3.3e-07 30.8 0.3 4.7 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T316111_1 - 0.076 13.2 0.1 0.74 10.0 0.1 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 T316111_2 - 3e-09 37.2 0.0 0.006 17.3 0.0 4.1 3 0 0 3 3 3 2 WD domain, G-beta repeat IN_DBD_C PF00552.19 T171951_2 - 0.095 11.9 0.0 0.095 11.9 0.0 1.7 2 0 0 2 2 2 0 Integrase DNA binding domain HERV-K_REC PF15695.3 T171951_3 - 0.00011 22.1 1.1 0.00019 21.3 1.1 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 zf-MIZ PF02891.18 T322877_2 - 1.7e-22 78.8 4.5 1.7e-22 78.8 4.5 2.7 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 T322877_2 - 1.6e-05 24.5 1.1 5.1e-05 22.9 1.1 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit GCV_T PF01571.19 T242511_3 - 5e-76 255.3 1.0 3.4e-59 200.2 0.0 2.2 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.9 T242511_3 - 1.3e-21 76.5 0.0 2.1e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain EF-hand_7 PF13499.4 T186533_2 - 2.6e-09 37.3 4.1 4.6e-09 36.5 4.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 T186533_2 - 2e-08 33.1 2.2 0.00072 18.8 0.4 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T186533_2 - 5.7e-08 32.0 1.9 6e-05 22.5 0.6 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 T186533_2 - 1.6e-05 24.5 2.1 3.4e-05 23.4 2.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 T186533_2 - 0.00083 18.6 1.2 0.27 10.7 0.4 2.3 2 0 0 2 2 2 2 EF hand COX17 PF05051.11 T248921_3 - 1.6e-19 69.8 6.8 4.5e-19 68.4 6.8 1.8 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Popeye PF04831.11 T248921_3 - 1e-08 35.3 0.0 1e-08 35.3 0.0 2.1 2 0 0 2 2 2 1 Popeye protein conserved region zf-H2C2_2 PF13465.4 T251523_1 - 4e-24 83.8 83.1 4.1e-05 23.7 5.9 12.2 12 0 0 12 12 12 8 Zinc-finger double domain BTB PF00651.29 T251523_1 - 9.4e-22 77.2 0.1 1.8e-21 76.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 T251523_1 - 1.5e-14 53.4 78.0 0.00011 22.3 2.1 10.6 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T251523_1 - 1.4e-13 50.2 78.6 0.15 12.8 0.8 11.3 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T251523_1 - 1.4e-07 31.5 38.5 0.0016 18.5 0.0 9.0 9 0 0 9 9 9 3 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T251523_1 - 4.9e-05 22.9 0.7 4.9e-05 22.9 0.7 5.8 6 0 0 6 6 6 2 zinc-finger C2H2-type zf-met PF12874.5 T251523_1 - 0.00065 19.9 0.3 0.00065 19.9 0.3 7.7 7 0 0 7 7 7 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 T251523_1 - 0.0018 18.1 54.9 0.44 10.4 1.0 9.6 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_8 PF15909.3 T251523_1 - 0.0021 18.2 1.7 0.0021 18.2 1.7 4.9 3 2 2 5 5 5 1 C2H2-type zinc ribbon FIBP PF05427.9 T061432_2 - 1.3e-168 560.7 0.2 1.6e-168 560.5 0.2 1.0 1 0 0 1 1 1 1 Acidic fibroblast growth factor binding (FIBP) PAD_N PF08526.8 T004474_2 - 1.6e-08 34.8 0.0 2.5e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain PAD_N PF08526.8 T004474_3 - 5.8e-15 55.5 0.0 1e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain IL8 PF00048.18 T145987_1 - 1.1e-38 131.0 9.3 2.9e-19 68.9 2.3 2.4 2 0 0 2 2 2 2 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.18 T145987_3 - 2.5e-22 78.7 1.2 2.5e-22 78.7 1.2 2.0 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like WD40 PF00400.30 T063550_1 - 1.6e-19 69.7 17.7 8.8e-05 23.1 0.0 8.6 8 0 0 8 8 8 6 WD domain, G-beta repeat ATG16 PF08614.9 T063550_1 - 2.3e-14 54.0 0.0 3.3e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) ANAPC4_WD40 PF12894.5 T063550_1 - 0.11 12.7 0.0 33 4.7 0.0 3.4 2 2 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain ATG16 PF08614.9 T063550_2 - 9.9e-12 45.3 13.3 1.4e-11 44.9 13.3 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Fringe PF02434.14 T233336_2 - 3.4e-91 305.0 0.0 5.7e-91 304.3 0.0 1.3 1 0 0 1 1 1 1 Fringe-like CARD PF00619.19 T233336_2 - 1e-18 67.0 0.0 2.7e-18 65.7 0.0 1.8 2 0 0 2 2 2 1 Caspase recruitment domain CARD_2 PF16739.3 T233336_2 - 0.046 13.6 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Caspase recruitment domain ERM PF00769.17 T233336_2 - 1.4 8.6 40.1 1.6 8.4 9.0 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Cadherin_2 PF08266.10 T290265_1 - 2e-06 27.4 0.1 3.3e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Cadherin-like Cadherin PF00028.15 T290265_3 - 1.9e-70 233.2 0.0 8.3e-17 61.3 0.1 6.3 5 1 1 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 T290265_3 - 2.1e-63 212.4 4.7 3.5e-63 211.7 4.7 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 T290265_3 - 9.4e-16 57.3 0.5 4.7e-13 48.6 0.1 3.8 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 T290265_3 - 1.5e-05 25.5 0.1 4.8e-05 23.9 0.1 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal DUF4958 PF16319.3 T290265_3 - 0.0057 14.7 0.0 0.011 13.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4958) DUF1725 PF08333.9 T054298_1 - 0.0057 16.1 0.5 0.012 15.1 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) JAB PF01398.19 T054298_2 - 6.2e-26 90.6 0.0 9.8e-26 89.9 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.4 T054298_2 - 1.8e-23 83.0 0.1 3.2e-23 82.2 0.1 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function DUF2043 PF09740.7 T259343_3 - 1.5e-38 131.5 0.1 3.9e-38 130.2 0.1 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2043) HLH PF00010.24 T312166_2 - 7.5e-11 41.7 0.2 1.5e-10 40.7 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RNA_pol_3_Rpc31 PF11705.6 T333849_3 - 0.0003 21.0 12.6 0.00043 20.5 12.6 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.8 T333849_3 - 0.00071 18.9 9.9 0.001 18.4 9.9 1.1 1 0 0 1 1 1 1 BUD22 PPP4R2 PF09184.9 T333849_3 - 0.017 14.6 15.3 0.025 14.0 15.3 1.1 1 0 0 1 1 1 0 PPP4R2 Myc_N PF01056.16 T333849_3 - 0.023 14.4 7.6 0.039 13.7 7.6 1.3 1 0 0 1 1 1 0 Myc amino-terminal region SDA1 PF05285.10 T333849_3 - 0.037 13.4 17.8 0.052 12.9 17.8 1.1 1 0 0 1 1 1 0 SDA1 DUF4746 PF15928.3 T333849_3 - 0.043 13.1 13.8 0.069 12.4 13.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1777 PF08648.10 T333849_3 - 0.17 12.0 6.0 0.26 11.4 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) NOA36 PF06524.10 T333849_3 - 0.28 10.4 15.9 0.4 9.9 15.9 1.1 1 0 0 1 1 1 0 NOA36 protein RNA_pol_Rpc4 PF05132.12 T333849_3 - 0.32 11.3 3.8 0.53 10.6 3.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 CPSF100_C PF13299.4 T333849_3 - 0.33 11.0 4.6 0.58 10.2 4.6 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.15 T333849_3 - 0.36 10.8 2.0 0.53 10.2 2.0 1.2 1 0 0 1 1 1 0 DDHD domain Mlh1_C PF16413.3 T333849_3 - 0.39 9.9 5.0 0.68 9.1 5.0 1.3 1 0 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus DUF1682 PF07946.12 T333849_3 - 0.42 9.6 10.4 0.63 9.1 10.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SpoIIP PF07454.9 T333849_3 - 0.43 9.9 7.3 0.64 9.3 7.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.12 T333849_3 - 0.52 8.4 13.1 0.76 7.9 13.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.15 T333849_3 - 0.53 8.8 4.2 0.77 8.3 4.2 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.10 T333849_3 - 0.55 9.9 10.8 0.91 9.2 10.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pox_Ag35 PF03286.12 T333849_3 - 0.92 9.1 12.0 1.5 8.4 12.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF1510 PF07423.9 T333849_3 - 1.3 8.3 19.1 1.9 7.7 19.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TRAP_alpha PF03896.14 T333849_3 - 1.5 7.8 13.3 2.3 7.2 13.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Na_trans_assoc PF06512.11 T333849_3 - 1.5 9.0 11.3 2.6 8.2 11.3 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated PTPRCAP PF15713.3 T333849_3 - 1.6 8.9 20.1 3.3 7.9 20.1 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF913 PF06025.10 T333849_3 - 1.7 7.4 5.1 2.5 6.8 5.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) EIIBC-GUT_N PF03612.12 T333849_3 - 1.9 8.1 3.4 3.2 7.3 3.4 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus FAM176 PF14851.4 T333849_3 - 2 8.0 12.9 3.5 7.2 12.9 1.3 1 0 0 1 1 1 0 FAM176 family AIF_C PF14721.4 T333849_3 - 2.1 8.6 5.8 3.5 7.9 5.8 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RNA_polI_A34 PF08208.9 T333849_3 - 2.5 8.0 14.9 0.74 9.8 11.2 1.8 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Astro_capsid_p PF12226.6 T333849_3 - 2.6 7.0 11.2 3.6 6.5 11.2 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Saw1 PF11561.6 T333849_3 - 3 7.2 4.7 4.5 6.6 4.7 1.2 1 0 0 1 1 1 0 Single strand annealing-weakened 1 DNA_pol_phi PF04931.11 T333849_3 - 3.3 5.6 25.3 4.8 5.0 25.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Afi1 PF07792.10 T333849_3 - 4.9 7.5 8.5 9.1 6.6 8.5 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TFIIF_alpha PF05793.10 T333849_3 - 5.4 5.3 22.5 7.6 4.9 22.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4820 PF16091.3 T333849_3 - 5.8 6.1 7.8 9.6 5.4 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Tim54 PF11711.6 T333849_3 - 5.9 5.4 12.3 9 4.8 12.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Di19_C PF14571.4 T333849_3 - 9.8 6.6 8.7 21 5.6 8.7 1.4 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal HERV-K_env_2 PF13804.4 T004786_1 - 2.6e-07 30.5 0.2 4.1e-07 29.8 0.2 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Phospholip_A2_1 PF00068.17 T004786_2 - 3.2e-32 111.1 9.0 5.3e-26 91.1 2.7 2.3 2 0 0 2 2 2 2 Phospholipase A2 HERV-K_env_2 PF13804.4 T004786_2 - 7.6e-24 84.2 0.1 1.3e-23 83.5 0.1 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_REC PF15695.3 T004786_2 - 0.00012 22.0 2.6 0.00012 22.0 2.6 2.1 2 1 0 2 2 2 1 Rec (regulator of expression encoded by corf) of HERV-K-113 GP41 PF00517.15 T004786_3 - 0.0021 17.8 0.1 0.004 16.9 0.1 1.3 1 0 0 1 1 1 1 Retroviral envelope protein zf-MIZ PF02891.18 T322878_1 - 1.5e-22 79.0 4.5 1.5e-22 79.0 4.5 2.8 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 T322878_1 - 9.6e-06 25.2 1.1 4.5e-05 23.1 1.1 2.2 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF1115 PF06544.10 T307332_2 - 1.5e-11 44.5 0.2 6.3e-11 42.4 0.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) RWD PF05773.20 T307332_2 - 9.7e-09 35.4 0.0 1.8e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 RWD domain PNP_UDP_1 PF01048.18 T201558_3 - 2e-23 82.7 0.0 2.5e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily LIM PF00412.20 T241500_3 - 4.8e-28 97.0 32.4 3.8e-11 42.9 5.4 3.8 3 0 0 3 3 3 3 LIM domain Sushi PF00084.18 T027322_2 - 4.3e-62 206.5 49.5 1.3e-09 38.4 1.4 9.1 9 0 0 9 9 9 7 Sushi repeat (SCR repeat) Sushi_2 PF09014.8 T027322_2 - 0.00098 18.9 13.2 0.13 12.1 0.1 5.2 4 2 2 6 6 6 2 Beta-2-glycoprotein-1 fifth domain Sushi PF00084.18 T027322_3 - 0.00019 21.8 1.5 0.00036 21.0 1.5 1.5 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) DUF4472 PF14739.4 T124434_1 - 9.4e-25 87.3 2.0 9.4e-25 87.3 2.0 3.8 4 1 0 4 4 4 1 Domain of unknown function (DUF4472) CAGE1 PF15066.4 T124434_1 - 0.031 12.8 0.1 0.031 12.8 0.1 2.0 2 0 0 2 2 2 0 Cancer-associated gene protein 1 family Rab_bind PF16704.3 T124434_1 - 0.045 13.7 0.8 1.1 9.2 0.1 2.7 2 0 0 2 2 2 0 Rab binding domain PRKG1_interact PF15898.3 T028098_3 - 6.2e-35 120.1 20.6 9.8e-35 119.4 20.6 1.3 1 0 0 1 1 1 1 cGMP-dependent protein kinase interacting domain GRIP PF01465.18 T366439_1 - 6.8e-14 51.4 0.5 1.9e-13 50.0 0.5 1.8 1 0 0 1 1 1 1 GRIP domain SCAI PF12070.6 T366439_3 - 2.9e-210 699.5 4.4 3.7e-210 699.2 4.4 1.1 1 0 0 1 1 1 1 Protein SCAI InaF-motif PF15018.4 T177881_2 - 3.5e-13 49.0 4.3 8.6e-13 47.8 4.3 1.7 1 0 0 1 1 1 1 TRP-interacting helix DUF4594 PF15266.4 T177881_3 - 3.4e-58 196.9 25.9 3.4e-58 196.9 25.9 2.4 2 1 1 3 3 3 1 Domain of unknown function (DUF4594) PHD PF00628.27 T057908_2 - 1.5e-11 43.9 6.2 1.5e-11 43.9 6.2 2.4 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.4 T057908_2 - 0.012 15.0 0.8 0.037 13.4 0.8 2.0 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.20 T057908_2 - 0.036 13.8 9.3 0.021 14.6 2.0 3.9 4 0 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) AT_hook PF02178.17 T057908_2 - 0.057 13.2 2.2 0.2 11.5 2.2 2.0 1 0 0 1 1 1 0 AT hook motif Zf_RING PF16744.3 T057908_2 - 0.13 12.3 3.8 0.52 10.3 3.8 2.1 1 0 0 1 1 1 0 KIAA1045 RING finger Seryl_tRNA_N PF02403.20 T057908_2 - 3.9 7.6 19.7 4.3 7.5 4.2 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain RhoGAP PF00620.25 T080588_2 - 2.7e-50 170.0 0.0 4.5e-50 169.3 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 T080588_2 - 3.6e-09 36.9 0.0 7.8e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.4 T080588_2 - 9.3e-07 28.5 0.0 2e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.24 T080588_2 - 3.1e-06 26.9 0.0 9.4e-06 25.4 0.0 1.9 2 0 0 2 2 2 1 WW domain SH3_1 PF00018.26 T080588_2 - 1.9e-05 24.0 0.0 3.8e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain PH_9 PF15410.4 T080588_2 - 0.075 13.3 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain GHMP_kinases_C PF08544.11 T080588_2 - 0.12 12.6 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 GHMP kinases C terminal DUF2575 PF10837.6 T333156_1 - 0.13 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) zf-C3HC PF07967.11 T333156_3 - 7.1e-35 119.7 0.1 7.1e-35 119.7 0.1 3.0 3 0 0 3 3 3 1 C3HC zinc finger-like Rsm1 PF08600.8 T333156_3 - 1.9e-16 59.8 4.1 9.3e-11 41.6 0.1 2.9 3 0 0 3 3 3 2 Rsm1-like Yippee-Mis18 PF03226.12 T333156_3 - 0.043 13.9 4.1 0.45 10.6 0.1 2.5 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF3915 PF13054.4 T372021_1 - 0.39 10.6 4.6 0.79 9.6 4.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 T372021_1 - 4.5 5.3 14.6 6.4 4.8 14.6 1.1 1 0 0 1 1 1 0 Atrophin-1 family F5_F8_type_C PF00754.23 T372021_2 - 9.7e-25 87.0 0.3 1.5e-24 86.4 0.3 1.3 1 0 0 1 1 1 1 F5/8 type C domain DUF3915 PF13054.4 T372021_2 - 3.8 7.4 9.5 6.9 6.6 9.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) SCRG1 PF15224.4 T274530_1 - 1.4e-47 159.5 6.1 2.9e-47 158.5 6.1 1.5 1 0 0 1 1 1 1 Scrapie-responsive protein 1 GPS2_interact PF15784.3 T142454_1 - 5.7e-35 119.7 6.8 5.7e-35 119.7 6.8 4.5 3 0 0 3 3 3 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 T142454_1 - 1e-17 63.9 0.2 5.9e-12 45.4 0.2 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T142454_1 - 0.0068 16.5 1.9 0.091 12.9 0.3 2.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Peptidase_C48 PF02902.17 T077763_2 - 5e-47 160.4 3.2 9.5e-47 159.5 3.2 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF4501 PF14946.4 T000448_1 - 1.3e-79 266.3 4.3 3.2e-70 235.7 0.6 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4501) ATG13 PF10033.7 T058003_3 - 1.3e-12 47.7 0.0 1e-06 28.4 0.1 2.4 1 1 1 2 2 2 2 Autophagy-related protein 13 Dynein_heavy PF03028.13 T243395_1 - 3.7e-92 309.6 0.5 4.8e-92 309.2 0.5 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.11 T243395_1 - 3.2e-06 26.4 0.0 4.6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 DHC_N2 PF08393.11 T243395_2 - 7.9e-132 440.0 7.8 1.2e-131 439.4 7.8 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 T243395_2 - 3e-99 331.3 0.1 9.2e-99 329.7 0.0 1.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.5 T243395_2 - 5.2e-35 120.9 0.1 9.8e-35 120.0 0.0 1.5 2 0 0 2 2 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.12 T243395_2 - 5e-15 55.6 0.0 4.3e-06 26.6 0.0 4.4 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.4 T243395_2 - 4.5e-08 33.6 0.2 0.089 13.2 0.0 4.9 5 0 0 5 5 4 1 AAA domain AAA_22 PF13401.4 T243395_2 - 5.7e-07 29.8 0.1 0.38 10.9 0.0 3.7 3 0 0 3 3 3 2 AAA domain AAA PF00004.27 T243395_2 - 9.1e-07 29.2 0.2 2 8.7 0.0 3.8 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 T243395_2 - 1e-05 25.8 0.0 0.27 11.4 0.0 3.6 3 0 0 3 3 3 1 AAA ATPase domain T2SSE PF00437.18 T243395_2 - 6e-05 22.1 0.1 0.32 9.9 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein RNA_helicase PF00910.20 T243395_2 - 0.00028 21.1 0.9 2.2 8.6 0.0 4.1 5 0 0 5 5 4 1 RNA helicase AAA_33 PF13671.4 T243395_2 - 0.00059 19.9 0.3 0.74 9.8 0.1 3.4 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.19 T243395_2 - 0.00087 18.6 0.5 0.18 11.0 0.0 3.4 4 0 0 4 4 3 1 Magnesium chelatase, subunit ChlI ResIII PF04851.13 T243395_2 - 0.0026 17.7 2.1 0.95 9.3 0.0 2.7 3 0 0 3 3 2 2 Type III restriction enzyme, res subunit AAA_30 PF13604.4 T243395_2 - 0.0072 15.9 4.0 3.4 7.2 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.4 T243395_2 - 0.01 16.0 1.2 5.1 7.3 0.0 3.7 4 0 0 4 4 3 0 AAA domain Cytidylate_kin PF02224.16 T243395_2 - 0.013 15.1 0.1 0.78 9.3 0.0 2.9 3 0 0 3 3 3 0 Cytidylate kinase DEAD PF00270.27 T243395_2 - 0.016 14.9 0.0 4.5 6.9 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_29 PF13555.4 T243395_2 - 0.017 14.7 0.4 0.15 11.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.25 T243395_2 - 0.023 15.1 0.2 0.15 12.4 0.0 2.2 2 0 0 2 2 2 0 ABC transporter Rad17 PF03215.13 T243395_2 - 0.036 12.8 1.7 3.5 6.3 0.0 2.7 3 0 0 3 3 3 0 Rad17 cell cycle checkpoint protein T2SSM PF04612.10 T243395_2 - 0.11 12.4 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M TsaE PF02367.15 T243395_2 - 0.17 11.8 3.9 2.9 7.8 0.1 3.2 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.24 T243395_2 - 0.17 11.4 0.0 5.1 6.6 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.4 T243395_2 - 0.29 10.7 1.1 30 4.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain PhoH PF02562.14 T243395_2 - 0.3 10.4 4.1 0.97 8.7 0.0 2.9 3 0 0 3 3 3 0 PhoH-like protein SRP54 PF00448.20 T243395_2 - 0.39 10.2 1.5 8.7 5.8 0.1 3.0 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain DUF853 PF05872.10 T243395_2 - 0.95 7.8 2.1 8.2 4.7 0.0 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF853) AAA_25 PF13481.4 T243395_2 - 1.7 8.1 6.1 2.6 7.4 0.1 2.9 3 0 0 3 3 3 0 AAA domain Dynein_heavy PF03028.13 T243395_3 - 4.6e-167 557.2 0.0 1.6e-166 555.4 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.5 T243395_3 - 6.6e-92 306.5 0.4 3.8e-90 300.7 0.7 2.5 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 T243395_3 - 1.1e-81 273.8 0.1 1.5e-81 273.4 0.1 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.5 T243395_3 - 2.1e-52 178.1 3.7 3.1e-52 177.6 3.7 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.5 T243395_3 - 3.9e-13 49.2 0.0 8.9e-13 48.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 FUSC-like PF12805.5 T243395_3 - 1.1 8.1 2.5 6.5 5.6 0.0 2.8 2 1 1 3 3 3 0 FUSC-like inner membrane protein yccS DUF3584 PF12128.6 T243395_3 - 1.3 6.3 12.0 1.6 6.0 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Alanine_zipper PF11839.6 T243395_3 - 1.5 9.1 8.8 5.6 7.2 8.8 2.0 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Fez1 PF06818.13 T243395_3 - 2.2 8.5 12.6 0.48 10.7 0.4 2.4 2 0 0 2 2 2 0 Fez1 DUF3450 PF11932.6 T243395_3 - 6 5.9 9.5 0.35 10.0 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) zf-RING_2 PF13639.4 T225857_1 - 6.1e-10 39.1 6.0 1.7e-09 37.7 6.0 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 T225857_1 - 1.3e-07 31.2 6.2 3.9e-07 29.7 6.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T225857_1 - 7.7e-07 28.8 6.3 2e-06 27.4 6.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 T225857_1 - 2.3e-06 27.7 5.9 6.6e-06 26.2 5.9 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 T225857_1 - 7.8e-05 22.4 7.2 0.0002 21.1 7.2 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 T225857_1 - 0.0002 21.1 4.0 0.00054 19.8 4.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 T225857_1 - 0.00024 20.8 4.3 0.00024 20.8 4.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 T225857_1 - 0.002 17.6 4.3 0.0053 16.3 4.3 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.5 T225857_1 - 0.14 12.1 1.8 0.36 10.8 1.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PAM2 PF07145.13 T225857_1 - 0.16 11.6 1.5 0.49 10.1 0.0 2.5 2 0 0 2 2 2 0 Ataxin-2 C-terminal region FANCL_C PF11793.6 T225857_1 - 0.29 11.2 3.7 0.7 10.0 3.7 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.4 T225857_1 - 0.62 9.9 5.9 2.1 8.2 5.9 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.9 T225857_1 - 3.7 7.8 8.3 11 6.3 8.3 1.9 1 0 0 1 1 1 0 RING-like domain TPR_1 PF00515.26 T225857_3 - 0.00016 21.2 8.3 0.0019 17.8 0.4 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 T225857_3 - 0.00026 20.7 6.0 0.0087 16.0 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 T225857_3 - 0.019 15.1 0.0 0.063 13.5 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Oest_recep PF02159.13 T313691_1 - 2.4e-64 215.8 3.7 3.9e-64 215.2 3.7 1.3 1 0 0 1 1 1 1 Oestrogen receptor Hormone_recep PF00104.28 T313691_1 - 5.2e-34 117.5 3.7 7.9e-34 116.9 3.7 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 T313691_1 - 6.5e-31 106.5 13.9 1.2e-30 105.6 13.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ESR1_C PF12743.5 T313691_1 - 6.8e-23 80.0 1.7 2e-22 78.5 1.5 2.0 2 0 0 2 2 2 1 Oestrogen-type nuclear receptor final C-terminal RhoGAP PF00620.25 T080575_1 - 4.8e-21 75.0 0.0 7.3e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 T080575_1 - 9.5e-09 35.6 0.0 2.1e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 PH domain WW PF00397.24 T080575_1 - 7.1e-06 25.7 0.0 2.2e-05 24.2 0.0 1.9 1 0 0 1 1 1 1 WW domain SH3_9 PF14604.4 T080575_2 - 2.5e-06 27.1 0.0 4.9e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T080575_2 - 3.7e-05 23.1 0.0 9.1e-05 21.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain RhoGAP PF00620.25 T080575_3 - 1.1e-07 31.6 0.0 1.9e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain HECT PF00632.23 T209260_3 - 2.6e-87 293.0 0.4 6.8e-87 291.7 0.0 1.9 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) WWE PF02825.18 T209260_3 - 0.00029 21.2 0.1 0.00084 19.7 0.1 1.8 1 0 0 1 1 1 1 WWE domain UNC45-central PF11701.6 T209260_3 - 0.015 15.1 1.0 0.046 13.5 0.0 2.3 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central HEAT_2 PF13646.4 T209260_3 - 0.2 11.9 0.3 0.99 9.7 0.1 2.4 2 0 0 2 2 2 0 HEAT repeats CUB PF00431.18 T125852_1 - 4.7e-12 46.1 0.0 6.9e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 CUB domain WSC PF01822.17 T125852_1 - 6.4e-06 26.1 1.6 1.6e-05 24.8 1.6 1.7 1 0 0 1 1 1 1 WSC domain Kringle PF00051.16 T125852_3 - 7.2e-06 26.1 1.4 1.3e-05 25.3 1.4 1.4 1 0 0 1 1 1 1 Kringle domain WSC PF01822.17 T125852_3 - 3.2e-05 23.9 0.0 5.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 WSC domain GAGE PF05831.9 T374713_2 - 9.8e-41 138.5 10.9 9.8e-41 138.5 10.9 1.8 2 0 0 2 2 2 1 GAGE protein CBM_21 PF03370.11 T374713_2 - 1.6e-26 92.5 0.0 2.8e-26 91.7 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 T374713_2 - 1.4e-06 28.7 0.0 2.5e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) PGC7_Stella PF15549.4 T072975_2 - 0.11 12.3 0.4 0.18 11.6 0.4 1.2 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain RhoGEF PF00621.18 T167201_1 - 5.1e-32 111.4 3.0 5.1e-32 111.4 3.0 2.2 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.27 T167201_1 - 3.1e-06 27.5 0.0 7.1e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 PH domain zf-C2H2_4 PF13894.4 T167201_1 - 0.15 12.8 0.9 1 10.2 0.2 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Atg14 PF10186.7 T167201_1 - 1.1 8.2 14.2 3.6 6.4 14.2 2.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6 PF04111.10 T167201_1 - 2.5 7.3 23.0 7.8 5.7 23.0 1.9 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4407 PF14362.4 T167201_1 - 6 6.0 19.9 14 4.8 19.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pkinase_Tyr PF07714.15 T300654_1 - 1.2e-83 280.2 0.0 1.6e-83 279.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T300654_1 - 3.4e-37 128.1 0.0 2.6e-36 125.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 T300654_1 - 9.2e-20 70.9 0.0 1.4e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Lamprin PF06403.9 T300654_1 - 0.058 13.2 0.5 0.15 11.9 0.5 1.6 1 0 0 1 1 1 0 Lamprin HOIP-UBA PF16678.3 T101675_2 - 3.8e-51 173.0 0.1 5.8e-51 172.4 0.1 1.3 1 0 0 1 1 1 1 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase PUB PF09409.8 T101675_2 - 3e-13 49.4 0.0 5.6e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 PUB domain IBR PF01485.19 T101675_2 - 2.8e-07 30.5 7.2 2.8e-07 30.5 7.2 6.1 5 2 1 6 6 6 3 IBR domain, a half RING-finger domain zf-RanBP PF00641.16 T101675_2 - 3.6e-05 22.9 33.1 0.0019 17.3 0.9 5.1 4 0 0 4 4 4 3 Zn-finger in Ran binding protein and others NMD3 PF04981.11 T101675_2 - 7.4 5.8 13.0 17 4.6 12.3 2.0 1 1 0 1 1 1 0 NMD3 family IRF-3 PF10401.7 T101675_3 - 1.6e-44 151.7 0.0 2.4e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 T101675_3 - 4.4e-36 123.2 0.2 4.4e-36 123.2 0.2 1.9 2 0 0 2 2 2 1 Interferon regulatory factor transcription factor Rad21_Rec8_N PF04825.11 T101675_3 - 4.6e-23 81.4 0.0 7.8e-23 80.6 0.0 1.3 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.14 T101675_3 - 2.1e-19 68.5 0.0 3.8e-19 67.6 0.0 1.4 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein PID PF00640.21 T165188_2 - 1.6e-46 157.7 0.0 2.2e-46 157.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.22 T165188_2 - 7e-16 57.9 0.0 1.1e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 SH2 domain C2 PF00168.28 T165188_3 - 2.1e-06 27.8 0.0 3.5e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 C2 domain PDZ PF00595.22 T244759_1 - 1.2e-64 214.5 5.3 9.4e-14 51.4 0.1 5.5 5 0 0 5 5 5 5 PDZ domain (Also known as DHR or GLGF) MAGI_u5 PF16666.3 T244759_1 - 9.8e-36 122.7 9.7 9.8e-36 122.7 9.7 3.2 2 0 0 2 2 2 1 Unstructured region on MAGI MAGI_u1 PF16663.3 T244759_1 - 1.2e-31 108.3 3.1 5.7e-31 106.1 3.1 2.3 1 0 0 1 1 1 1 Unstructured region on MAGI PDZ_2 PF13180.4 T244759_1 - 7.2e-29 99.8 0.0 6e-05 23.2 0.0 6.0 6 0 0 6 6 6 5 PDZ domain WW PF00397.24 T244759_1 - 5.4e-18 64.5 3.9 7.2e-10 38.5 0.4 2.6 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 T244759_1 - 3.1e-10 39.9 0.0 3.1e-10 39.9 0.0 2.2 2 0 0 2 2 2 1 Guanylate kinase Tricorn_PDZ PF14685.4 T244759_1 - 2.4e-07 30.5 4.8 0.18 11.7 0.0 4.8 5 0 0 5 5 5 3 Tricorn protease PDZ domain Serglycin PF04360.10 T244759_1 - 0.061 13.1 0.4 0.13 12.1 0.4 1.5 1 0 0 1 1 1 0 Serglycin DUF853 PF05872.10 T244759_1 - 2 6.8 4.0 3.3 6.1 4.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) tRNA_anti-codon PF01336.23 T204880_2 - 0.00018 21.3 0.2 0.00032 20.5 0.2 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain PI-PLC-X PF00388.17 T001268_1 - 8.2e-18 64.2 0.1 1.3e-17 63.6 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain EF-hand_like PF09279.9 T001268_1 - 3.9e-15 56.0 0.0 5.9e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_7 PF13499.4 T001268_1 - 6.7e-11 42.4 0.6 1.1e-10 41.7 0.2 1.6 2 0 0 2 2 2 1 EF-hand domain pair PH_12 PF16457.3 T001268_1 - 3.5e-08 33.9 0.0 5.7e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_1 PF00036.30 T001268_1 - 1.5e-07 30.3 0.7 0.0009 18.5 0.0 2.5 2 1 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T001268_1 - 6.2e-06 25.6 0.6 0.01 15.6 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_10 PF14788.4 T001268_1 - 2e-05 24.2 0.1 3.6e-05 23.4 0.1 1.5 1 0 0 1 1 1 1 EF hand PH PF00169.27 T001268_1 - 0.00077 19.8 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 PH domain EF-hand_5 PF13202.4 T001268_1 - 0.0027 17.0 1.9 0.0029 16.9 0.1 1.9 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 T001268_1 - 0.016 14.9 2.8 0.08 12.6 0.1 2.7 2 1 1 3 3 3 0 EF-hand domain pair Mcp5_PH PF12814.5 T001268_1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology EF-hand_4 PF12763.5 T001268_1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand ABC_tran_Xtn PF12848.5 T001268_1 - 0.22 11.4 0.5 0.38 10.7 0.5 1.3 1 0 0 1 1 1 0 ABC transporter PI-PLC-Y PF00387.17 T001268_3 - 1.7e-39 134.6 0.7 2.5e-39 134.1 0.7 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain PI-PLC-X PF00388.17 T001268_3 - 1.9e-15 56.6 0.0 3.6e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain C2 PF00168.28 T001268_3 - 2.6e-15 56.4 0.0 4.5e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 C2 domain DEADboxA PF12343.6 T034593_2 - 0.11 12.8 8.8 0.045 14.1 6.2 1.7 2 0 0 2 2 2 0 Cold shock protein DEAD box A zf-MYND PF01753.16 T034593_3 - 1e-09 38.2 14.8 1e-09 38.2 14.8 2.3 2 0 0 2 2 2 1 MYND finger DUF4171 PF13775.4 T232800_2 - 1.2e-52 177.8 19.3 1.2e-52 177.8 19.3 4.6 5 0 0 5 5 5 1 Domain of unknown function (DUF4171) HMG_box PF00505.17 T232800_2 - 7.7e-14 51.7 1.7 7.7e-14 51.7 1.7 2.6 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T232800_2 - 6.2e-08 33.0 1.5 1.6e-07 31.7 1.5 1.6 1 0 0 1 1 1 1 HMG-box domain VHS PF00790.17 T232800_3 - 1.6e-45 154.3 0.0 2.3e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 VHS domain GAT PF03127.12 T232800_3 - 1.4e-24 86.1 2.4 2.1e-24 85.5 2.4 1.3 1 0 0 1 1 1 1 GAT domain Filament PF00038.19 T078873_1 - 5.3e-211 699.5 72.9 6.9e-114 380.5 34.8 2.0 2 0 0 2 2 2 2 Intermediate filament protein Keratin_2_head PF16208.3 T078873_1 - 5.9e-20 71.9 35.3 2.1e-12 47.3 2.6 4.8 4 1 1 5 5 4 3 Keratin type II head TPR_MLP1_2 PF07926.10 T078873_1 - 1.4e-11 44.4 61.6 9e-05 22.4 0.4 6.5 6 0 0 6 6 6 4 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 T078873_1 - 0.00062 18.6 62.2 0.036 12.8 13.2 5.3 2 2 1 4 4 4 4 Spc7 kinetochore protein TSNAXIP1_N PF15739.3 T078873_1 - 0.00096 19.4 0.9 0.00096 19.4 0.9 5.8 6 1 1 7 7 5 2 Translin-associated factor X-interacting N-terminus DUF4924 PF16271.3 T078873_1 - 0.0012 18.8 7.0 0.018 15.0 0.5 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4924) BAT PF15915.3 T078873_1 - 0.083 12.6 2.9 0.21 11.3 0.5 2.4 2 0 0 2 2 2 0 GAF and HTH_10 associated domain Glutaredoxin2_C PF04399.11 T078873_1 - 0.19 11.4 5.2 2.2 8.0 0.3 2.8 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain Alanine_zipper PF11839.6 T078873_1 - 0.24 11.6 24.9 0.55 10.4 9.6 2.9 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Vps51 PF08700.9 T078873_1 - 0.27 11.2 3.1 8.6 6.4 0.2 3.3 2 0 0 2 2 2 0 Vps51/Vps67 Reo_sigmaC PF04582.10 T078873_1 - 0.29 10.4 14.8 2.6 7.2 1.0 3.8 2 2 0 3 3 3 0 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.7 T078873_1 - 0.31 10.9 64.7 0.039 13.8 10.3 6.5 3 3 4 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CALCOCO1 PF07888.9 T078873_1 - 0.69 8.3 65.7 11 4.3 23.9 3.7 2 2 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF5082 PF16888.3 T078873_1 - 2.5 8.3 38.2 0.087 13.0 0.8 5.5 5 1 1 6 6 6 0 Domain of unknown function (DUF5082) NPV_P10 PF05531.10 T078873_1 - 3.3 8.1 12.4 12 6.4 0.1 4.9 3 1 2 5 5 5 0 Nucleopolyhedrovirus P10 protein Virulence_fact PF13769.4 T078873_1 - 7.6 6.6 10.3 15 5.6 0.1 4.2 4 0 0 4 4 3 0 Virulence factor Filament PF00038.19 T078873_3 - 0.16 11.4 0.2 0.23 10.9 0.2 1.1 1 0 0 1 1 1 0 Intermediate filament protein Fasciclin PF02469.20 T093092_3 - 2.7e-105 347.6 0.1 4.7e-28 97.8 0.0 4.2 4 0 0 4 4 4 4 Fasciclin domain Peptidase_M10 PF00413.22 T000868_1 - 3.4e-06 26.9 0.0 5.4e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Matrixin Peptidase_M10 PF00413.22 T000868_2 - 1.6e-19 70.2 1.5 2.3e-19 69.6 1.5 1.2 1 0 0 1 1 1 1 Matrixin DUF4953 PF16313.3 T000868_2 - 0.063 12.3 2.1 0.094 11.8 2.1 1.1 1 0 0 1 1 1 0 Met-zincin Reprolysin_3 PF13582.4 T000868_2 - 0.085 13.3 0.2 0.14 12.5 0.2 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T000868_2 - 0.13 11.8 0.7 0.2 11.1 0.7 1.1 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.6 T000868_2 - 0.33 10.4 1.1 0.59 9.6 1.1 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Astacin PF01400.22 T000868_2 - 0.34 10.4 1.5 0.53 9.7 1.5 1.1 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Ank_2 PF12796.5 T000868_3 - 2.1e-38 130.7 7.0 7.9e-11 42.3 0.6 5.4 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T000868_3 - 1.9e-36 123.4 16.0 2.6e-08 33.9 0.1 7.1 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.4 T000868_3 - 9.2e-34 115.3 3.8 2.3e-09 37.4 0.0 6.5 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 T000868_3 - 4.8e-26 89.9 12.3 1.3e-05 25.3 0.0 9.6 9 0 0 9 9 9 5 Ankyrin repeat Ank_3 PF13606.4 T000868_3 - 6.5e-25 84.4 6.4 0.00084 19.5 0.1 8.7 9 0 0 9 9 9 5 Ankyrin repeat MIB_HERC2 PF06701.11 T000868_3 - 1.5e-22 79.5 9.3 1.5e-22 79.5 9.3 2.3 2 0 0 2 2 2 1 Mib_herc2 zf-C3HC4_3 PF13920.4 T000868_3 - 1.2e-09 37.8 26.0 1.2e-06 28.2 8.4 4.1 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) ZZ PF00569.15 T000868_3 - 2e-07 30.6 10.4 2e-07 30.6 10.4 2.8 2 0 0 2 2 2 1 Zinc finger, ZZ type ShK PF01549.22 T000868_3 - 1.1e-05 25.7 5.0 1.1e-05 25.7 5.0 2.7 2 0 0 2 2 2 1 ShK domain-like Ig_2 PF13895.4 T000868_3 - 4.1e-05 23.7 0.1 9.9e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain RRM_1 PF00076.20 T020318_2 - 3.9e-37 125.8 0.0 1.4e-18 66.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OTU PF02338.17 T020318_2 - 4.5e-24 85.2 0.0 7.6e-24 84.5 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease 3-PAP PF12578.6 T020318_2 - 6e-22 77.7 0.3 1.1e-21 76.8 0.3 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein Myotub-related PF06602.12 T020318_2 - 1.6e-15 56.8 0.0 2.2e-10 39.9 0.0 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain zf-A20 PF01754.14 T020318_2 - 1.5e-05 24.7 12.2 5.3e-05 22.9 12.2 2.1 1 0 0 1 1 1 1 A20-like zinc finger RRM_7 PF16367.3 T020318_2 - 0.00019 21.4 0.0 0.018 15.0 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif UBA_4 PF14555.4 T020318_2 - 0.00028 20.5 0.0 0.00052 19.6 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.11 T020318_2 - 0.0012 18.2 0.1 0.004 16.6 0.0 1.9 2 0 0 2 2 2 1 TAP C-terminal domain Myotub-related PF06602.12 T020318_3 - 1.1e-27 96.8 0.1 1.6e-27 96.2 0.1 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain CLCA PF08434.9 T014406_2 - 0 1208.7 0.1 0 1208.5 0.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel VWA_2 PF13519.4 T014406_2 - 8.5e-11 42.3 0.0 1.9e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 T014406_2 - 1.4e-08 35.0 0.0 2.6e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 T014406_2 - 0.0042 16.4 0.0 0.0078 15.5 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Gag_p10 PF02337.15 T014406_3 - 2.3e-13 49.7 0.2 5.7e-13 48.4 0.1 1.7 2 0 0 2 2 2 1 Retroviral GAG p10 protein Y_phosphatase PF00102.25 T158291_1 - 3.2e-143 475.1 0.9 2.3e-77 259.6 0.0 2.7 3 0 0 3 3 3 2 Protein-tyrosine phosphatase MAM PF00629.21 T158291_1 - 5.1e-32 110.8 0.0 1.2e-31 109.6 0.0 1.7 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu fn3 PF00041.19 T158291_1 - 5.5e-26 90.6 8.2 1.8e-09 37.7 0.0 5.2 5 0 0 5 5 5 3 Fibronectin type III domain ig PF00047.23 T158291_1 - 3.5e-12 46.2 0.0 1.6e-11 44.1 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain DSPc PF00782.18 T158291_1 - 6.3e-08 32.4 0.1 0.0078 15.9 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain I-set PF07679.14 T158291_1 - 0.00017 21.5 0.0 0.00039 20.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T158291_1 - 0.00033 21.1 0.0 0.0016 18.9 0.0 2.1 2 0 0 2 2 1 1 Immunoglobulin domain Y_phosphatase3 PF13350.4 T158291_1 - 0.0004 20.3 0.0 0.036 13.9 0.0 2.4 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 T158291_1 - 0.00078 19.5 0.0 0.16 12.0 0.0 2.5 2 0 0 2 2 2 1 Inositol hexakisphosphate Pur_ac_phosph_N PF16656.3 T158291_1 - 0.0018 18.7 1.1 0.43 11.1 0.1 3.6 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain ECSCR PF15820.3 T158291_1 - 0.004 16.8 0.1 0.0089 15.7 0.1 1.5 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator Ig_2 PF13895.4 T158291_1 - 0.013 15.7 0.9 0.059 13.6 0.0 2.5 3 0 0 3 3 2 0 Immunoglobulin domain EphA2_TM PF14575.4 T158291_1 - 0.069 13.8 0.2 0.25 12.0 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DctM PF06808.10 T158291_1 - 0.096 11.3 0.2 0.15 10.8 0.2 1.1 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporter, DctM component DUF948 PF06103.9 T158291_1 - 0.15 12.2 0.1 0.39 10.9 0.1 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) C2 PF00168.28 T349099_3 - 8.1e-37 125.5 0.2 5.8e-19 68.2 0.0 2.9 3 0 0 3 3 3 2 C2 domain FYVE_2 PF02318.14 T349099_3 - 6.8e-10 39.1 19.8 1.4e-09 38.0 10.2 2.7 2 0 0 2 2 2 2 FYVE-type zinc finger PDZ PF00595.22 T349099_3 - 1.4e-05 25.3 0.0 2.9e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) IQ PF00612.25 T069460_3 - 5.8e-05 22.4 0.7 0.00013 21.3 0.7 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif V-set PF07686.15 T069271_1 - 3.2e-20 72.2 0.0 4.9e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T069271_1 - 0.0002 21.7 0.1 0.00048 20.5 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T069271_1 - 0.0021 18.2 0.2 0.0085 16.3 0.2 1.9 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T069271_1 - 0.0091 16.0 0.3 0.032 14.2 0.3 1.9 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T069271_1 - 0.01 15.7 0.0 0.02 14.8 0.0 1.5 1 1 0 1 1 1 0 Immunoglobulin I-set domain OAD_gamma PF04277.11 T069271_1 - 0.19 12.2 0.0 0.38 11.2 0.0 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain SSF PF00474.15 T010683_1 - 5.5e-38 130.7 13.2 8e-38 130.2 13.2 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.15 T010683_2 - 3.5e-19 68.8 0.2 4.9e-19 68.3 0.2 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.15 T010683_3 - 2.1e-67 227.7 4.9 6.1e-52 176.7 0.0 2.1 2 0 0 2 2 2 2 Sodium:solute symporter family ELMO_CED12 PF04727.11 T192983_1 - 0.00041 20.4 0.0 0.0007 19.6 0.0 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family ELMO_CED12 PF04727.11 T192983_2 - 2.3e-05 24.5 0.1 3.8e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family MAGE PF01454.17 T380997_2 - 5.9e-12 45.6 0.0 4.3e-09 36.2 0.0 2.2 1 1 0 1 1 1 1 MAGE family MAGE_N PF12440.6 T380997_2 - 0.0046 17.5 19.4 4.3 8.0 19.4 2.9 1 1 0 1 1 1 1 Melanoma associated antigen family N terminal Acyltransferase PF01553.19 T194374_2 - 0.0029 17.1 0.0 0.0069 15.9 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Suf PF05843.12 T103618_1 - 0.0032 17.4 0.1 0.017 15.0 0.0 1.9 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) TPR_14 PF13428.4 T103618_2 - 0.00037 20.9 0.1 1.2 10.0 0.1 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 T103618_2 - 0.13 12.8 0.0 0.28 11.8 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.15 T103618_2 - 0.18 11.8 0.8 17 5.7 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 T103618_2 - 0.29 11.3 1.6 5.7 7.2 0.9 2.7 1 1 0 2 2 2 0 Tetratricopeptide repeat Fox-1_C PF12414.6 T232905_1 - 2.4e-21 75.7 3.1 4.5e-21 74.8 3.1 1.4 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 T232905_1 - 1.9e-17 62.7 0.1 3.1e-17 62.0 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fox-1_C PF12414.6 T232905_3 - 2.1e-10 40.7 7.5 3.7e-10 39.9 7.5 1.3 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal Tim44 PF04280.13 T205573_2 - 0.12 12.4 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Tim44-like domain T_cell_tran_alt PF15128.4 T242501_3 - 4.2e-42 141.7 0.0 8.2e-42 140.8 0.0 1.4 1 0 0 1 1 1 1 T-cell leukemia translocation-altered PH_9 PF15410.4 T047783_1 - 5e-36 123.5 0.0 7.6e-36 123.0 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 T047783_1 - 6e-12 45.9 0.0 9.5e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 PH domain SMRP1 PF15181.4 T357490_1 - 4.1e-22 78.9 0.0 6.1e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 Spermatid-specific manchette-related protein 1 FAM219A PF15260.4 T357490_3 - 1.4e-50 170.7 2.6 2.5e-50 169.9 2.6 1.4 1 0 0 1 1 1 1 Protein family FAM219A TIG PF01833.22 T305095_1 - 4.2e-72 238.1 40.4 1.7e-09 37.5 0.1 13.5 12 1 1 13 13 13 10 IPT/TIG domain PA14 PF07691.10 T305095_1 - 0.0062 16.2 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 PA14 domain G8 PF10162.7 T305095_3 - 3.3e-52 175.6 0.0 4.5e-29 100.9 0.0 2.8 2 0 0 2 2 2 2 G8 domain Beta_helix PF13229.4 T305095_3 - 4e-19 68.9 6.2 1.3e-08 34.7 0.0 3.9 2 2 1 3 3 3 3 Right handed beta helix region NosD PF05048.11 T305095_3 - 1.3e-06 27.8 3.8 0.002 17.3 0.3 3.2 2 1 1 3 3 3 3 Periplasmic copper-binding protein (NosD) DNA_pol_lambd_f PF10391.7 T322641_1 - 3.1e-19 68.5 0.4 5.2e-19 67.7 0.4 1.4 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.4 T322641_1 - 6.4e-09 35.9 0.0 1.7e-08 34.6 0.0 1.7 2 0 0 2 2 2 1 Helix-hairpin-helix domain Cdd1 PF11731.6 T322641_1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Pathogenicity locus Sigma54_AID PF00309.18 T322641_1 - 0.29 10.9 2.4 1.8 8.3 1.0 2.2 2 0 0 2 2 2 0 Sigma-54 factor, Activator interacting domain (AID) DNA_pol_B_thumb PF14791.4 T322641_3 - 1e-20 73.5 0.3 1.6e-20 72.8 0.3 1.3 1 0 0 1 1 1 1 DNA polymerase beta thumb tRNA_anti-codon PF01336.23 T204870_3 - 0.0002 21.2 0.2 0.00034 20.4 0.2 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain zf-C2H2 PF00096.24 T335753_1 - 8.5e-25 85.7 34.7 3.6e-06 27.0 0.6 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T335753_1 - 1.7e-18 66.0 27.6 2.5e-06 27.5 1.5 6.2 6 0 0 6 6 5 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 T335753_1 - 2.1e-17 62.2 32.7 0.00063 20.2 0.3 6.1 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T335753_1 - 5.3e-07 29.1 21.2 0.03 14.0 0.1 5.7 5 0 0 5 5 5 3 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 T335753_1 - 4.4e-05 23.2 26.0 0.034 14.0 0.8 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.5 T335753_1 - 0.0014 18.8 1.0 0.0014 18.8 1.0 3.2 3 0 0 3 3 3 1 Zinc-finger of C2H2 type CpXC PF14353.4 T335753_1 - 0.006 16.5 14.2 0.079 12.9 1.1 4.6 4 1 0 4 4 4 1 CpXC protein zf-C2H2_jaz PF12171.6 T335753_1 - 0.0098 16.1 13.2 0.011 15.9 0.1 4.3 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T335753_1 - 0.039 14.0 16.8 0.094 12.7 0.3 4.2 2 1 2 4 4 4 0 Zinc ribbon domain FYDLN_acid PF09538.8 T335753_1 - 0.14 12.7 8.3 11 6.6 0.0 4.2 2 1 1 4 4 4 0 Protein of unknown function (FYDLN_acid) SprT-like PF10263.7 T335753_1 - 0.34 10.6 9.9 44 3.7 0.0 3.2 2 1 0 2 2 2 0 SprT-like family zf-Di19 PF05605.10 T335753_1 - 1.8 8.8 20.2 0.018 15.2 2.1 3.7 2 1 2 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding ADK_lid PF05191.12 T335753_1 - 3.6 7.6 11.9 28 4.7 0.1 4.9 4 1 2 6 6 6 0 Adenylate kinase, active site lid Terminase_GpA PF05876.10 T335753_1 - 9.8 4.5 12.3 0.48 8.8 0.5 2.1 1 1 0 2 2 2 0 Phage terminase large subunit (GpA) HLH PF00010.24 T002186_3 - 3.2e-12 46.1 6.4 5.3e-12 45.4 6.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CH PF00307.29 T058946_3 - 2.8e-22 78.8 0.1 6.9e-22 77.6 0.0 1.6 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 T058946_3 - 0.00099 18.8 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain DRMBL PF07522.12 T048901_1 - 3.6e-35 120.5 0.1 1.2e-34 118.9 0.0 1.9 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.5 T048901_1 - 1.5e-05 24.5 0.1 2.6e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.25 T048901_1 - 0.0022 17.9 0.1 0.0038 17.1 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Glyco_hydro_45 PF02015.14 T048901_1 - 0.063 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 45 RMMBL PF07521.10 T048901_1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain E2F_TDP PF02319.18 T055813_3 - 1.1e-41 140.5 0.3 3.9e-20 71.5 0.0 2.4 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.17 T055813_3 - 0.00044 20.0 0.0 0.0012 18.5 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB UPF0122 PF04297.12 T055813_3 - 0.028 14.5 0.1 0.062 13.4 0.1 1.6 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like Gasdermin PF04598.10 T146897_1 - 5e-12 45.5 5.2 7.4e-12 44.9 5.2 1.1 1 0 0 1 1 1 1 Gasdermin family Gasdermin PF04598.10 T146897_2 - 1e-20 74.1 0.1 1.4e-20 73.6 0.1 1.1 1 0 0 1 1 1 1 Gasdermin family ORMDL PF04061.12 T146897_3 - 3.7e-52 175.6 4.7 5.3e-52 175.1 4.7 1.2 1 0 0 1 1 1 1 ORMDL family G-alpha PF00503.18 T132963_1 - 1.1e-105 353.6 0.8 1.6e-105 353.0 0.8 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 T132963_1 - 1.1e-11 44.4 0.1 2.3e-11 43.3 0.1 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 T132963_1 - 0.0077 15.5 0.2 0.013 14.7 0.2 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF1725 PF08333.9 T039603_1 - 0.035 13.6 0.1 0.077 12.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) BioT2 PF15368.4 T039603_3 - 6.3e-86 286.5 0.9 1.2e-85 285.5 0.9 1.5 1 0 0 1 1 1 1 Spermatogenesis family BioT2 DUF4670 PF15709.3 T205934_3 - 1.7e-260 865.6 103.0 3.1e-260 864.7 103.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4670) zf-HC5HC2H_2 PF13832.4 T355438_2 - 1.4e-14 54.1 0.1 1.4e-14 54.1 0.1 2.3 3 0 0 3 3 3 1 PHD-zinc-finger like domain PHD_2 PF13831.4 T355438_2 - 1.2e-12 47.0 10.5 3.4e-12 45.6 10.5 1.8 1 0 0 1 1 1 1 PHD-finger PHD PF00628.27 T355438_2 - 7.3e-05 22.4 5.6 7.3e-05 22.4 5.6 2.3 2 0 0 2 2 2 1 PHD-finger JmjC PF02373.20 T355438_3 - 1.1e-43 148.2 0.1 2.2e-43 147.2 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.15 T355438_3 - 9.8e-12 44.5 0.0 2e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 jmjN domain GST_N_4 PF17172.2 T308513_3 - 1.4e-29 102.6 0.0 2.4e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.2 T308513_3 - 4.8e-18 64.6 0.0 9.9e-18 63.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.7 T308513_3 - 1.9e-15 57.1 0.0 3.9e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.4 T308513_3 - 0.026 14.3 0.0 0.051 13.4 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain zf-H2C2_2 PF13465.4 T200475_1 - 2.3e-28 97.2 60.9 1.9e-07 31.1 5.1 9.0 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2 PF00096.24 T200475_1 - 1.6e-21 75.4 72.9 0.0003 20.9 5.0 9.1 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T200475_1 - 1.2e-12 47.4 69.7 0.013 16.1 1.2 9.3 8 0 0 8 8 8 6 C2H2-type zinc finger zf-Di19 PF05605.10 T200475_1 - 6.4e-08 32.6 1.9 6.4e-08 32.6 1.9 4.0 4 0 0 4 4 3 1 Drought induced 19 protein (Di19), zinc-binding Homeobox PF00046.27 T200475_1 - 0.0003 20.4 0.1 0.00099 18.7 0.0 1.9 2 0 0 2 2 1 1 Homeobox domain zf-C2H2_jaz PF12171.6 T200475_1 - 0.0003 20.9 55.5 0.031 14.5 1.7 8.8 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 T200475_1 - 0.0016 18.0 0.5 0.0016 18.0 0.5 4.7 4 0 0 4 4 3 2 C2H2-type zinc-finger domain zf-met PF12874.5 T200475_1 - 0.0079 16.4 58.4 0.41 11.0 3.5 8.7 8 0 0 8 8 8 4 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.3 T200475_1 - 1 9.1 7.8 45 3.8 0.0 4.2 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2H2_6 PF13912.4 T200475_1 - 1.7 8.6 66.2 0.067 13.0 1.4 8.5 8 0 0 8 8 8 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T200475_1 - 2.5 8.8 23.5 0.83 10.3 1.3 5.2 3 1 1 4 4 4 0 zinc-ribbon family CUT PF02376.13 T086451_1 - 1.5e-76 252.4 0.4 1.2e-24 86.2 0.0 3.7 3 0 0 3 3 3 3 CUT domain Homeobox PF00046.27 T086451_1 - 1.1e-12 47.5 1.1 3e-12 46.0 1.1 1.9 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 T086451_1 - 0.0028 17.4 0.2 0.0088 15.8 0.2 1.9 1 0 0 1 1 1 1 Homeobox KN domain DUF4407 PF14362.4 T086451_1 - 0.019 14.2 14.7 0.097 11.9 14.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) IncA PF04156.12 T086451_1 - 0.87 9.2 32.6 2 8.0 0.0 3.4 2 1 1 3 3 3 0 IncA protein DUF4618 PF15397.4 T086451_1 - 5.7 6.2 23.9 0.02 14.2 2.9 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) SAPS PF04499.13 T236395_1 - 1.7e-115 386.5 0.0 8.1e-70 235.8 0.3 2.8 2 1 1 3 3 3 2 SIT4 phosphatase-associated protein DUF4527 PF15030.4 T260415_2 - 1.2e-143 477.5 16.2 1.9e-143 476.8 16.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4527) AAA_13 PF13166.4 T260415_2 - 1.7 7.1 11.5 0.45 9.0 1.7 2.1 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.25 T304099_3 - 3.7e-24 85.2 0.0 5.9e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.23 T304099_3 - 0.00067 19.9 0.2 0.0017 18.5 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 T304099_3 - 0.022 14.7 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase MIP PF00230.18 T078363_1 - 3e-72 242.9 16.2 4e-72 242.5 16.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein MIP PF00230.18 T078363_2 - 5e-67 225.8 16.2 7e-67 225.3 16.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein Spectrin PF00435.19 T372877_3 - 3.3e-65 217.0 113.4 3.2e-13 49.9 2.5 10.9 9 2 2 11 11 11 8 Spectrin repeat EF-hand_2 PF09068.9 T372877_3 - 3e-40 137.0 1.3 3e-40 137.0 1.3 2.2 2 0 0 2 2 2 1 EF hand EF-hand_3 PF09069.9 T372877_3 - 1.6e-39 134.1 0.1 7.9e-39 131.8 0.0 2.4 2 0 0 2 2 2 1 EF-hand ZZ PF00569.15 T372877_3 - 4.1e-19 68.0 4.2 8.2e-19 67.0 4.2 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type WW PF00397.24 T372877_3 - 1.1e-08 34.7 2.1 1.1e-08 34.7 2.1 1.9 2 0 0 2 2 2 1 WW domain RasGEF PF00617.17 T372877_3 - 0.12 12.4 1.8 0.57 10.2 1.8 2.2 1 0 0 1 1 1 0 RasGEF domain Bromodomain PF00439.23 T147675_1 - 6.6e-22 77.3 0.1 1e-21 76.6 0.1 1.3 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.23 T147675_1 - 1.5e-09 38.0 0.1 2.5e-09 37.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 T147675_1 - 9.3e-07 28.7 0.0 1.6e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 T147675_1 - 3.2e-05 24.1 0.3 5.6e-05 23.3 0.3 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PCAF_N PF06466.9 T147675_2 - 3.8e-116 386.9 2.6 5.9e-116 386.3 2.6 1.3 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain RIG-I_C-RD PF11648.6 T147675_2 - 2e-36 124.7 0.0 4e-36 123.7 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of RIG-I Helicase_C PF00271.29 T147675_2 - 4.6e-19 68.7 0.7 3.1e-18 66.0 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 T147675_2 - 7.2e-18 65.0 0.0 1.4e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.27 T147675_2 - 6.9e-15 55.1 1.2 2.6e-14 53.3 0.0 2.4 2 1 0 2 2 2 1 DEAD/DEAH box helicase RasGEF PF00617.17 T367917_2 - 9.8e-52 175.5 0.3 3.2e-51 173.8 0.1 1.9 1 1 1 2 2 2 1 RasGEF domain RasGEF_N PF00618.18 T367917_2 - 2.9e-09 37.0 0.2 2.9e-09 37.0 0.2 2.2 3 0 0 3 3 3 1 RasGEF N-terminal motif SLY PF12485.6 T313358_1 - 2.7e-44 151.5 9.9 9.9e-44 149.7 9.9 2.1 1 0 0 1 1 1 1 Lymphocyte signaling adaptor protein SAM_2 PF07647.15 T313358_1 - 2.1e-19 69.2 0.0 1.9e-09 37.4 0.0 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 T313358_1 - 2.1e-16 60.0 0.0 1.3e-07 31.8 0.0 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SH3_2 PF07653.15 T313358_1 - 2.7e-05 23.7 0.0 5.5e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T313358_1 - 0.02 14.4 0.0 0.038 13.5 0.0 1.5 1 0 0 1 1 1 0 SH3 domain FUSC PF04632.10 T205287_1 - 1 7.7 2.6 1.4 7.3 2.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMF_TATA_bd PF12325.6 T205287_1 - 1.2 9.3 15.1 0.68 10.0 12.3 1.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding OATP PF03137.18 T064051_2 - 1.3e-193 644.1 9.2 2e-193 643.5 9.2 1.3 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 T064051_2 - 1.5e-18 66.8 20.1 1.5e-18 66.8 20.1 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily zinc_ribbon_9 PF14369.4 T064051_2 - 0.043 13.9 0.3 0.15 12.2 0.3 1.9 1 0 0 1 1 1 0 zinc-ribbon Kazal_2 PF07648.13 T064051_2 - 0.095 12.8 2.8 0.27 11.3 2.8 1.8 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Myelin_PLP PF01275.17 T274880_2 - 1.7e-90 302.9 24.2 1.7e-90 302.9 24.2 1.8 2 0 0 2 2 2 1 Myelin proteolipid protein (PLP or lipophilin) L27_1 PF09058.8 T140771_1 - 4.9e-06 26.4 0.1 8e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 L27_1 Guanylate_kin PF00625.19 T140771_2 - 1.3e-67 226.9 0.1 1.8e-67 226.4 0.1 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 T140771_2 - 6.8e-65 215.3 10.1 4.9e-21 74.7 0.1 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_assoc PF10600.7 T140771_2 - 2e-26 92.5 6.5 2e-26 92.5 6.5 2.4 2 0 0 2 2 2 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 T140771_2 - 3.4e-17 62.4 1.7 2.8e-06 27.4 0.0 3.3 3 0 0 3 3 3 3 PDZ domain MAGUK_N_PEST PF10608.7 T140771_2 - 1.2e-12 48.2 4.9 3.4e-09 37.1 0.8 2.5 1 1 1 2 2 2 2 Polyubiquitination (PEST) N-terminal domain of MAGUK SH3_1 PF00018.26 T140771_2 - 4.2e-08 32.5 0.0 1e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 T140771_2 - 1.6e-07 30.8 0.1 6.5e-07 28.8 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.4 T140771_2 - 0.0092 15.7 0.1 0.02 14.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF4573 PF15140.4 T378357_1 - 0.025 14.3 6.7 0.039 13.6 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4573) Pkinase PF00069.23 T378357_3 - 1.2e-54 185.3 0.0 5.3e-54 183.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T378357_3 - 1.2e-41 142.6 0.0 4.2e-41 140.8 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase CNH PF00780.20 T378357_3 - 3.4e-38 131.7 0.0 5.2e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 CNH domain Kinase-like PF14531.4 T378357_3 - 0.0069 15.6 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 T378357_3 - 0.022 14.0 0.1 0.04 13.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA_7 PF12775.5 T155589_2 - 7.3e-37 127.0 0.0 1.1e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 Dynein_heavy PF03028.13 T155589_3 - 1.4e-235 783.7 0.0 7.6e-147 490.4 0.0 3.7 4 0 0 4 4 4 2 Dynein heavy chain and region D6 of dynein motor MT PF12777.5 T155589_3 - 7.2e-211 699.2 12.3 7.2e-211 699.2 12.3 1.7 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.5 T155589_3 - 1.2e-169 562.2 0.1 1.7e-169 561.7 0.1 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 T155589_3 - 5.8e-125 415.9 0.8 4.4e-124 413.0 0.2 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_9 PF12781.5 T155589_3 - 8.1e-84 280.0 0.7 8.1e-84 280.0 0.7 2.0 2 0 0 2 2 1 1 ATP-binding dynein motor region D5 Spc7 PF08317.9 T155589_3 - 0.00073 18.4 2.2 0.00073 18.4 2.2 2.9 3 0 0 3 3 3 1 Spc7 kinetochore protein IncA PF04156.12 T155589_3 - 0.0042 16.8 1.4 0.0042 16.8 1.4 2.9 3 0 0 3 3 3 1 IncA protein GreA_GreB_N PF03449.13 T155589_3 - 0.071 13.1 2.1 0.25 11.4 2.1 1.9 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal Reo_sigmaC PF04582.10 T155589_3 - 0.099 11.9 2.1 1.3 8.2 0.0 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF390 PF04094.12 T155589_3 - 3.3 5.7 8.0 6.6 4.8 8.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF390) DUF4201 PF13870.4 T155589_3 - 8 5.9 17.5 0.81 9.2 2.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) DivIC PF04977.13 T155589_3 - 8.2 6.1 11.4 4.4 7.0 2.9 2.7 2 0 0 2 2 2 0 Septum formation initiator Sec16_C PF12931.5 T047254_3 - 0.00016 21.3 0.1 0.0037 16.8 0.1 2.1 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 ANAPC4_WD40 PF12894.5 T047254_3 - 0.00069 19.7 0.7 0.34 11.1 0.0 3.1 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 T047254_3 - 0.013 16.2 3.1 1 10.2 0.0 4.2 3 1 1 4 4 4 0 WD domain, G-beta repeat CLZ PF16526.3 T194965_2 - 3.6e-29 100.8 6.7 6.4e-29 100.0 6.7 1.4 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ion_trans PF00520.29 T194965_2 - 6.9e-25 87.5 8.7 6.9e-25 87.5 8.7 2.3 2 0 0 2 2 2 1 Ion transport protein cNMP_binding PF00027.27 T194965_2 - 1.7e-16 59.8 0.0 2.8e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Homeobox PF00046.27 T149721_1 - 1.5e-20 72.6 4.7 2.7e-20 71.8 4.7 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox PF00046.27 T149721_3 - 3.3e-60 199.6 36.6 3.8e-20 71.3 8.0 3.5 3 0 0 3 3 3 3 Homeobox domain DUF4074 PF13293.4 T149721_3 - 2.7e-32 110.7 10.4 6.5e-32 109.5 10.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4074) DUF2209 PF09974.7 T149721_3 - 0.0028 17.9 0.7 3.3 7.9 0.1 2.5 2 0 0 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2209) Homeobox_KN PF05920.9 T149721_3 - 0.14 12.0 13.6 6.9 6.5 0.5 3.9 3 0 0 3 3 3 0 Homeobox KN domain Terminase_5 PF06056.10 T149721_3 - 2 8.2 6.0 7.5 6.4 0.2 2.9 3 0 0 3 3 3 0 Putative ATPase subunit of terminase (gpP-like) LisH_2 PF16045.3 T371590_1 - 1.2e-14 52.9 0.3 2.4e-14 51.9 0.3 1.6 1 0 0 1 1 1 1 LisH LisH PF08513.9 T371590_1 - 0.0043 16.9 0.0 0.012 15.4 0.0 1.9 1 0 0 1 1 1 1 LisH DUF3372 PF11852.6 T371590_1 - 2.2 7.6 4.7 5 6.4 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3372) Rhomboid PF01694.20 T255872_3 - 0.00046 20.0 0.8 0.0009 19.1 0.8 1.4 1 0 0 1 1 1 1 Rhomboid family RhoGAP PF00620.25 T041680_2 - 3.5e-46 156.7 0.0 6.2e-46 155.8 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 T041680_2 - 3.4e-22 78.8 0.0 7.4e-22 77.7 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 T041680_2 - 6.9e-06 26.3 0.2 0.00029 21.1 0.2 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain ATG16 PF08614.9 T041680_2 - 0.00068 19.7 7.2 0.0012 19.0 7.2 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.5 T041680_2 - 0.0022 18.0 7.4 0.0036 17.3 7.4 1.2 1 0 0 1 1 1 1 Tropomyosin like PH_8 PF15409.4 T041680_2 - 0.0025 17.9 0.1 0.16 12.2 0.1 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain IncA PF04156.12 T041680_2 - 0.013 15.2 2.1 0.024 14.3 2.1 1.3 1 0 0 1 1 1 0 IncA protein PH_3 PF14593.4 T041680_2 - 0.024 14.6 0.1 0.062 13.3 0.0 1.6 2 0 0 2 2 1 0 PH domain HAUS-augmin3 PF14932.4 T041680_2 - 0.12 11.7 4.9 0.2 11.0 4.9 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 ADIP PF11559.6 T041680_2 - 0.17 11.8 6.7 0.3 11.0 6.7 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding CALCOCO1 PF07888.9 T041680_2 - 0.3 9.5 7.3 0.44 8.9 7.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like APG6 PF04111.10 T041680_2 - 0.39 9.9 4.6 0.6 9.3 4.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 TPR_MLP1_2 PF07926.10 T041680_2 - 2.3 8.1 10.8 3.8 7.4 10.8 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein CENP-Q PF13094.4 T041680_2 - 7.2 6.6 10.0 14 5.8 10.0 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Pkinase_Tyr PF07714.15 T300661_1 - 1.3e-83 280.1 0.0 1.7e-83 279.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T300661_1 - 3.8e-37 128.0 0.0 2.8e-36 125.1 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 T300661_1 - 9.7e-20 70.8 0.0 1.4e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Lamprin PF06403.9 T300661_1 - 0.064 13.1 0.5 0.16 11.8 0.5 1.6 1 0 0 1 1 1 0 Lamprin Filament PF00038.19 T078935_2 - 2.9e-66 224.0 12.4 3.7e-66 223.7 12.4 1.1 1 0 0 1 1 1 1 Intermediate filament protein BAT PF15915.3 T078935_2 - 0.0002 21.1 0.3 0.00041 20.1 0.3 1.4 1 0 0 1 1 1 1 GAF and HTH_10 associated domain CALCOCO1 PF07888.9 T078935_2 - 0.002 16.7 9.2 0.0027 16.2 9.2 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4924 PF16271.3 T078935_2 - 0.0027 17.6 1.1 0.0042 17.0 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4924) Spc7 PF08317.9 T078935_2 - 0.0064 15.3 6.9 0.0064 15.3 6.9 2.0 1 1 0 1 1 1 1 Spc7 kinetochore protein CCDC144C PF14915.4 T078935_2 - 0.012 14.6 7.4 0.018 14.0 7.4 1.2 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region GAS PF13851.4 T078935_2 - 0.025 13.8 8.1 0.045 13.0 8.1 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding BRE1 PF08647.9 T078935_2 - 0.065 13.2 7.0 0.42 10.6 1.8 2.3 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Vps5 PF09325.8 T078935_2 - 0.089 12.2 4.9 0.95 8.8 0.1 2.3 1 1 1 2 2 2 0 Vps5 C terminal like DUF812 PF05667.9 T078935_2 - 0.14 10.9 8.4 0.19 10.4 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) TPR_MLP1_2 PF07926.10 T078935_2 - 0.18 11.7 14.1 0.072 13.0 10.3 2.2 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Tropomyosin_1 PF12718.5 T078935_2 - 0.19 11.7 9.6 0.35 10.9 9.6 1.3 1 0 0 1 1 1 0 Tropomyosin like DUF1192 PF06698.9 T078935_2 - 0.28 11.1 4.6 1 9.3 4.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) IFT20 PF14931.4 T078935_2 - 0.3 11.1 7.1 0.63 10.1 7.1 1.5 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 DUF4407 PF14362.4 T078935_2 - 0.31 10.2 6.4 0.56 9.4 6.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1635 PF07795.9 T078935_2 - 0.39 10.5 4.4 0.76 9.6 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Muted PF14942.4 T078935_2 - 0.55 10.4 5.5 0.97 9.6 5.5 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein V_ATPase_I PF01496.17 T078935_2 - 0.71 7.6 2.8 1 7.1 2.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4201 PF13870.4 T078935_2 - 0.74 9.3 8.4 0.24 10.9 3.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Lebercilin PF15619.4 T078935_2 - 1.1 8.7 10.0 0.46 10.0 7.2 1.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ADIP PF11559.6 T078935_2 - 1.6 8.6 10.5 0.5 10.3 7.1 1.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.7 T078935_2 - 2.7 7.9 11.6 4.3 7.2 10.2 1.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIVA PF05103.11 T078935_2 - 2.8 7.9 9.4 5.6 6.9 9.4 1.5 1 0 0 1 1 1 0 DivIVA protein TSNAXIP1_N PF15739.3 T078935_2 - 2.9 8.2 7.3 0.61 10.4 2.1 2.3 1 1 1 2 2 2 0 Translin-associated factor X-interacting N-terminus DivIC PF04977.13 T078935_2 - 3.2 7.5 7.4 0.8 9.4 3.6 2.0 2 1 0 2 2 1 0 Septum formation initiator Seryl_tRNA_N PF02403.20 T078935_2 - 5.6 7.1 8.2 5.9 7.0 7.0 1.5 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Mod_r PF07200.11 T078935_2 - 8.1 6.4 8.2 23 4.9 7.8 1.8 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Jnk-SapK_ap_N PF09744.7 T078935_2 - 8.1 6.5 12.0 1.3 9.1 7.1 1.9 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Filament PF00038.19 T078935_3 - 8.3e-22 78.0 0.4 1.1e-21 77.6 0.4 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 T078935_3 - 1.6e-15 57.5 8.3 1.1e-10 41.8 1.3 2.3 1 1 1 2 2 2 2 Keratin type II head RyR PF02026.14 T033690_3 - 1.3e-125 409.7 10.6 4.3e-33 113.2 0.0 5.2 5 0 0 5 5 5 4 RyR domain RYDR_ITPR PF01365.19 T033690_3 - 5.5e-105 349.1 12.5 3.8e-77 258.2 0.0 3.9 4 0 0 4 4 4 2 RIH domain RR_TM4-6 PF06459.10 T033690_3 - 3.7e-94 315.5 0.8 3.7e-94 315.5 0.8 2.1 2 0 0 2 2 1 1 Ryanodine Receptor TM 4-6 SPRY PF00622.26 T033690_3 - 2e-67 224.7 2.3 5.8e-24 84.4 0.1 3.5 3 0 0 3 3 3 3 SPRY domain RIH_assoc PF08454.9 T033690_3 - 2.5e-33 113.8 1.0 1.1e-32 111.7 0.3 2.7 2 0 0 2 2 2 1 RyR and IP3R Homology associated Ion_trans PF00520.29 T033690_3 - 1.1e-13 50.9 13.1 1.9e-13 50.1 5.1 3.7 3 0 0 3 3 3 1 Ion transport protein EF-hand_8 PF13833.4 T033690_3 - 5.7e-07 29.1 0.1 3.2e-06 26.7 0.1 2.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.4 T033690_3 - 3.8e-06 27.1 1.1 1.9e-05 24.9 1.1 2.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 T033690_3 - 0.00012 21.3 0.4 0.0025 17.1 0.0 2.8 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 T033690_3 - 0.0048 16.6 1.1 0.024 14.4 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain GWT1 PF06423.10 T033690_3 - 0.55 10.2 4.5 2.9 7.9 0.0 3.5 3 0 0 3 3 3 0 GWT1 YjfB_motility PF14070.4 T033690_3 - 0.73 9.9 7.6 2.3 8.3 7.6 1.9 1 0 0 1 1 1 0 Putative motility protein DUF3408 PF11888.6 T033690_3 - 7.8 6.5 10.7 33 4.5 10.7 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) SET PF00856.26 T147880_1 - 0.00092 19.5 0.0 0.0014 18.9 0.0 1.2 1 0 0 1 1 1 1 SET domain EZH2_WD-Binding PF11616.6 T147880_2 - 5.9e-17 61.3 0.7 1.2e-16 60.4 0.7 1.5 1 0 0 1 1 1 1 WD repeat binding protein EZH2 SET PF00856.26 T147880_2 - 4e-06 27.2 1.0 1.2e-05 25.7 0.2 2.2 2 0 0 2 2 2 1 SET domain Myb_DNA-bind_5 PF13873.4 T352927_1 - 1.1e-23 83.0 0.0 2e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Syntaxin_2 PF14523.4 T352927_1 - 2.1e-21 76.0 2.7 2.1e-21 76.0 2.7 1.8 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.17 T352927_1 - 0.00036 20.3 0.2 0.00084 19.2 0.2 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.23 T352927_1 - 0.00059 19.4 7.8 0.0015 18.1 7.8 1.7 1 1 0 1 1 1 1 Syntaxin IncA PF04156.12 T352927_1 - 1.2 8.8 14.0 0.2 11.3 3.1 2.2 2 0 0 2 2 2 0 IncA protein MCPsignal PF00015.19 T352927_1 - 1.5 8.4 5.6 5.8 6.5 0.3 2.1 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CENP-H PF05837.10 T352927_1 - 2.3 8.5 10.0 0.089 13.1 2.2 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Lebercilin PF15619.4 T352927_1 - 5.2 6.5 7.4 0.26 10.8 1.6 1.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF883 PF05957.11 T352927_1 - 7.7 7.0 9.6 1.8 9.1 0.9 2.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) DASH_Dad4 PF08650.8 T352927_3 - 0.28 11.1 0.3 0.47 10.3 0.3 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad4 KxDL PF10241.7 T352927_3 - 2.4 8.3 5.1 4.1 7.6 5.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein SCP2 PF02036.15 T119348_1 - 1.8e-15 57.1 0.0 3.8e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family Band_7 PF01145.23 T119348_1 - 1.4e-14 54.4 0.0 2.3e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family GTF2I PF02946.12 T326518_2 - 1.9e-151 492.3 11.0 1.4e-30 105.0 0.0 5.3 5 0 0 5 5 5 5 GTF2I-like repeat DUF1725 PF08333.9 T067657_2 - 0.034 13.7 0.0 0.066 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) NNMT_PNMT_TEMT PF01234.15 T067657_3 - 3.5e-106 354.0 0.0 4.6e-106 353.5 0.0 1.1 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.4 T067657_3 - 0.0011 18.7 0.0 0.0021 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain REPA_OB_2 PF16900.3 T125159_3 - 2.4e-06 27.3 0.0 1e-05 25.2 0.0 2.0 2 0 0 2 2 2 1 Replication protein A OB domain DZR PF12773.5 T125159_3 - 0.011 15.7 0.2 0.029 14.3 0.2 1.7 1 0 0 1 1 1 0 Double zinc ribbon Rep_fac-A_C PF08646.8 T125159_3 - 0.015 14.9 0.3 0.032 13.8 0.3 1.5 1 0 0 1 1 1 0 Replication factor-A C terminal domain Pox_H7 PF04787.10 T125159_3 - 0.091 13.1 0.1 0.15 12.5 0.1 1.3 1 0 0 1 1 1 0 Late protein H7 Spt4 PF06093.11 T125159_3 - 0.61 10.1 4.8 16 5.6 0.4 3.3 3 0 0 3 3 3 0 Spt4/RpoE2 zinc finger zf-RING_4 PF14570.4 T170358_2 - 0.57 9.8 4.7 1.3 8.7 4.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain MnmE_helical PF12631.5 T170358_3 - 4.5e-45 154.2 0.0 5.5e-45 153.9 0.0 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.7 T170358_3 - 2.7e-36 124.2 0.0 4.3e-36 123.5 0.0 1.3 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.21 T170358_3 - 4.5e-15 55.6 0.0 8e-15 54.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 T170358_3 - 0.00071 19.5 0.1 0.0011 18.9 0.1 1.2 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.4 T170358_3 - 0.023 14.8 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 T170358_3 - 0.027 14.7 0.9 0.074 13.3 0.2 2.1 1 1 1 2 2 2 0 AAA ATPase domain FeoB_N PF02421.16 T170358_3 - 0.038 13.4 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_18 PF13238.4 T170358_3 - 0.071 13.5 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.14 T170358_3 - 0.11 12.2 0.0 0.97 9.2 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function, DUF258 NTPase_P4 PF11602.6 T170358_3 - 0.24 10.5 0.0 0.35 9.9 0.0 1.1 1 0 0 1 1 1 0 ATPase P4 of dsRNA bacteriophage phi-12 zf-DHHC PF01529.18 T055807_1 - 1e-29 103.2 18.9 1e-29 103.2 18.9 3.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_4 PF13637.4 T055807_1 - 4.3e-29 100.4 0.1 1.1e-09 38.5 0.0 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 T055807_1 - 3.1e-28 97.3 0.2 6.8e-09 35.7 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.5 T055807_1 - 5.2e-28 97.3 0.2 1e-12 48.3 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T055807_1 - 2e-24 82.8 1.4 1.6e-05 24.7 0.0 7.5 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.28 T055807_1 - 2.3e-19 68.7 2.8 0.00012 22.2 0.1 6.6 6 0 0 6 6 6 4 Ankyrin repeat Ephrin_lbd PF01404.17 T008280_1 - 1.2e-65 220.8 0.0 1.7e-65 220.2 0.0 1.2 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain fn3 PF00041.19 T008280_1 - 8.9e-22 77.1 0.0 2.7e-10 40.3 0.1 2.9 3 0 0 3 3 3 2 Fibronectin type III domain EphA2_TM PF14575.4 T008280_1 - 4.3e-09 36.9 0.0 4.3e-09 36.9 0.0 1.7 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Ephrin_rec_like PF07699.11 T008280_1 - 0.0074 15.9 1.1 0.0074 15.9 1.1 2.3 2 0 0 2 2 2 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.3 T008280_1 - 0.0083 16.5 0.1 0.086 13.3 0.1 2.2 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Pkinase_Tyr PF07714.15 T008280_3 - 6.7e-72 241.8 0.0 9.3e-72 241.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T008280_3 - 1.8e-27 96.2 0.0 2.6e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.28 T008280_3 - 8e-15 54.9 0.0 1.7e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T008280_3 - 1.1e-13 50.9 0.0 2.2e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ras PF00071.20 T022218_3 - 1.7e-49 167.4 0.0 2.4e-49 166.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T022218_3 - 1e-16 61.1 0.0 1.6e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T022218_3 - 2.3e-07 30.3 0.0 3.3e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family zf-GRF PF06839.10 T375230_2 - 1.4e-12 47.3 2.8 8.1e-12 44.9 0.5 2.9 2 0 0 2 2 2 1 GRF zinc finger Exo_endo_phos PF03372.21 T375230_2 - 2.4e-10 40.5 0.0 3.9e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MAGE PF01454.17 T375230_3 - 2.6e-19 69.6 0.1 8.5e-18 64.7 0.1 2.4 1 1 0 1 1 1 1 MAGE family DDE_1 PF03184.17 T272980_3 - 1.7e-33 115.5 0.1 2.4e-33 115.0 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 T272980_3 - 3.2e-19 68.6 0.0 5.3e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.11 T272980_3 - 3.4e-10 39.2 1.3 3.4e-10 39.2 1.3 2.0 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain CENP-B_dimeris PF09026.8 T272980_3 - 0.00014 22.1 0.2 0.00029 21.1 0.2 1.4 1 0 0 1 1 1 1 Centromere protein B dimerisation domain HTH_23 PF13384.4 T272980_3 - 0.023 14.4 0.0 0.12 12.1 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_1 PF01527.18 T272980_3 - 0.033 14.4 0.0 0.096 12.9 0.0 1.8 1 0 0 1 1 1 0 Transposase 2-oxoacid_dh PF00198.21 T057037_3 - 1.1e-40 139.4 0.0 1.6e-40 138.9 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 T057037_3 - 1.1e-18 66.7 0.5 1.8e-18 66.0 0.5 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.15 T057037_3 - 3.5e-06 27.1 0.0 7.7e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.4 T057037_3 - 0.053 13.3 0.0 0.24 11.2 0.0 1.9 1 1 1 2 2 2 0 Biotin-lipoyl like zf-H2C2_2 PF13465.4 T167865_2 - 1e-59 196.3 63.3 2e-09 37.4 2.4 11.7 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 T167865_2 - 1.9e-41 138.1 73.3 2.9e-06 27.3 1.0 11.3 10 0 0 10 10 10 9 Zinc finger, C2H2 type KRAB PF01352.25 T167865_2 - 6.9e-25 86.3 2.1 7.7e-25 86.2 0.3 2.0 2 0 0 2 2 2 1 KRAB box zf-C2H2_4 PF13894.4 T167865_2 - 1.8e-21 74.8 64.6 0.0066 17.1 3.8 11.2 11 0 0 11 11 11 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T167865_2 - 2.1e-16 59.3 54.4 6.8e-05 22.6 0.5 9.4 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T167865_2 - 4.7e-09 36.2 42.1 0.055 13.7 0.4 9.4 9 0 0 9 9 9 6 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T167865_2 - 0.05 13.3 36.6 0.22 11.2 0.0 8.9 9 0 0 9 9 9 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T167865_2 - 0.6 10.1 40.4 0.055 13.5 3.3 5.9 2 1 6 8 8 8 0 Zinc ribbon domain Dynamin_M PF01031.18 T367045_3 - 1.4e-111 372.2 3.8 1.4e-111 372.2 3.8 1.7 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.21 T367045_3 - 4.2e-54 183.0 0.0 9.7e-54 181.8 0.0 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.16 T367045_3 - 2e-27 95.1 2.3 3.8e-27 94.1 2.3 1.5 1 0 0 1 1 1 1 Dynamin GTPase effector domain PH PF00169.27 T367045_3 - 5.9e-12 45.9 1.0 1.1e-11 45.0 1.0 1.4 1 0 0 1 1 1 1 PH domain MMR_HSR1 PF01926.21 T367045_3 - 0.0032 17.4 0.0 0.012 15.5 0.0 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase PH_11 PF15413.4 T367045_3 - 1.1 9.6 3.8 1.6 9.0 2.0 2.2 2 1 0 2 2 2 0 Pleckstrin homology domain G8 PF10162.7 T349494_2 - 4.2e-31 107.5 0.0 6.8e-31 106.8 0.0 1.3 1 0 0 1 1 1 1 G8 domain Beta_helix PF13229.4 T349494_2 - 2.5e-09 37.0 5.3 0.00011 21.9 0.3 2.4 1 1 1 2 2 2 2 Right handed beta helix region TIG PF01833.22 T349494_3 - 1.5e-169 550.4 90.6 3.6e-18 65.3 0.2 14.8 13 1 1 14 14 14 14 IPT/TIG domain G8 PF10162.7 T349494_3 - 1.4e-37 128.4 0.2 2.8e-37 127.4 0.2 1.6 1 0 0 1 1 1 1 G8 domain PA14 PF07691.10 T349494_3 - 2.8e-09 36.8 0.2 6.7e-09 35.5 0.1 1.6 2 0 0 2 2 2 1 PA14 domain Beta_helix PF13229.4 T349494_3 - 0.00051 19.8 2.8 0.00051 19.8 2.8 3.0 2 1 1 3 3 3 2 Right handed beta helix region Herpes_UL73 PF03554.11 T349494_3 - 0.014 15.3 0.9 0.041 13.7 0.9 1.8 1 0 0 1 1 1 0 UL73 viral envelope glycoprotein Tom37 PF10568.7 T021951_2 - 1.4e-43 148.2 0.0 2.1e-43 147.6 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.2 T021951_2 - 8.6e-20 70.2 0.5 1.5e-19 69.4 0.5 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.2 T021951_2 - 1.5e-18 67.2 0.0 2.5e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.4 T021951_2 - 3.6e-05 23.5 0.0 8.9e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 T021951_2 - 0.045 13.8 0.0 0.081 13.0 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain V-set PF07686.15 T248490_2 - 1.4e-07 31.5 0.0 2.6e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 T248490_2 - 4.9e-05 23.3 0.4 0.00017 21.6 0.4 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 T248490_2 - 0.0071 16.8 0.1 0.014 15.9 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T248490_2 - 0.028 14.6 0.1 0.06 13.6 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.14 T248490_2 - 0.17 11.8 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain T-box PF00907.20 T321534_1 - 3.5e-43 147.8 0.0 5.4e-43 147.2 0.0 1.2 1 0 0 1 1 1 1 T-box TSP_1 PF00090.17 T318705_1 - 1.6e-48 162.6 218.0 1.3e-11 44.3 4.3 22.8 24 1 0 24 24 24 16 Thrombospondin type 1 domain Auts2 PF15336.4 T318705_1 - 0.39 10.7 1.9 0.66 9.9 1.9 1.3 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein Radical_SAM PF04055.19 T216397_2 - 1.3e-19 71.0 0.0 2.2e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.18 T216397_3 - 2.1e-21 75.6 0.1 3.6e-21 74.9 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.18 T216397_3 - 8.3e-12 44.8 0.0 1.3e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 TRAM domain Radical_SAM PF04055.19 T216397_3 - 0.037 14.3 0.0 0.067 13.4 0.0 1.4 1 0 0 1 1 1 0 Radical SAM superfamily CTNNBL PF08216.9 T217424_2 - 9.6e-41 138.0 0.9 1.8e-40 137.2 0.9 1.4 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.21 T217424_2 - 0.017 15.0 4.6 2.3 8.3 0.2 3.6 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat C1q PF00386.19 T155754_2 - 8.5e-37 126.1 2.4 1.2e-36 125.6 2.4 1.2 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 T155754_2 - 1.7e-07 30.8 13.4 1.7e-07 30.8 13.4 2.4 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) RhoGEF PF00621.18 T313986_3 - 2.9e-45 154.6 3.9 8.8e-45 153.0 3.9 1.9 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 T313986_3 - 3.6e-17 62.6 2.8 6.8e-14 52.1 0.1 2.9 3 0 0 3 3 3 2 PH domain PH_9 PF15410.4 T313986_3 - 8.2e-10 39.0 0.2 2.1e-09 37.6 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PDZ PF00595.22 T313986_3 - 4.9e-07 29.9 0.0 1e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RBD PF02196.13 T313986_3 - 0.0046 16.9 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Raf-like Ras-binding domain PH_6 PF15406.4 T313986_3 - 0.036 14.2 0.1 0.54 10.4 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.4 T313986_3 - 0.054 13.8 0.1 0.23 11.7 0.1 2.1 1 0 0 1 1 1 0 Pleckstrin homology domain PDZ_2 PF13180.4 T313986_3 - 0.066 13.4 0.0 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 PDZ domain RMI1_N PF08585.10 T095392_2 - 1.4e-23 83.6 0.0 1.5e-19 70.5 0.0 2.7 1 1 1 2 2 2 2 RecQ mediated genome instability protein TUDOR PF00567.22 T095392_2 - 1.2e-10 41.3 0.0 2.4e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Tudor domain SMN PF06003.10 T095392_2 - 3e-08 33.1 0.0 3e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 Survival motor neuron protein (SMN) UBA PF00627.29 T095392_2 - 7.9e-08 31.9 0.1 1.6e-07 30.9 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain DUF3472 PF11958.6 T095392_2 - 0.011 16.1 0.3 0.031 14.6 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3472) ATP-synt_ab PF00006.23 T248396_1 - 5.1e-108 359.5 0.0 6.9e-108 359.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.3 T248396_1 - 2.1e-43 146.9 0.0 3.5e-43 146.2 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.21 T248396_1 - 2.4e-14 53.5 2.1 4.3e-14 52.7 2.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF1211 PF06736.9 T259152_1 - 0.017 15.4 0.0 0.028 14.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1211) DUF1211 PF06736.9 T259152_2 - 4.9e-12 46.0 0.2 1e-11 45.0 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1211) DUF1211 PF06736.9 T259152_3 - 6e-23 81.0 0.0 1.1e-22 80.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1211) Sas10_Utp3 PF04000.13 T101411_2 - 8.3e-13 48.6 0.9 5.9e-12 45.9 0.4 2.5 3 0 0 3 3 3 1 Sas10/Utp3/C1D family TMEM247 PF15444.4 T101411_2 - 0.64 9.9 3.3 1.2 9.1 3.3 1.4 1 0 0 1 1 1 0 Transmembrane protein 247 TNFR_c6 PF00020.16 T002493_3 - 9.6e-05 22.6 9.2 9.6e-05 22.6 9.2 5.3 3 1 1 4 4 4 3 TNFR/NGFR cysteine-rich region LRR_8 PF13855.4 T331212_1 - 2e-36 123.4 39.6 5e-13 48.5 7.1 6.7 2 1 5 7 7 7 6 Leucine rich repeat LRR_4 PF12799.5 T331212_1 - 7.1e-21 73.7 39.5 0.0005 20.2 3.6 7.1 4 1 3 7 7 7 7 Leucine Rich repeats (2 copies) I-set PF07679.14 T331212_1 - 1.2e-12 47.6 0.0 2.6e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T331212_1 - 8e-12 45.5 0.0 1.9e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.4 T331212_1 - 6.8e-10 38.6 25.3 0.00024 20.5 0.4 4.2 1 1 3 4 4 4 4 Leucine-rich repeat fn3 PF00041.19 T331212_1 - 6.8e-07 29.4 0.1 1.4e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain LRRNT PF01462.16 T331212_1 - 3.7e-06 26.3 1.0 2.4e-05 23.7 1.0 2.5 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain ig PF00047.23 T331212_1 - 3.9e-06 26.8 0.0 8.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T331212_1 - 8.1e-06 26.0 0.0 1.7e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRRCT PF01463.22 T331212_1 - 0.0037 17.6 0.1 0.0091 16.3 0.1 1.7 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain Q_salvage PF10343.7 T361218_1 - 0.064 12.7 0.0 0.094 12.1 0.0 1.2 1 0 0 1 1 1 0 Potential Queuosine, Q, salvage protein family KH_1 PF00013.27 T361218_3 - 7.6e-42 140.8 13.9 1.7e-19 69.2 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 T361218_3 - 5.1e-26 90.5 9.8 8e-26 89.9 9.8 1.3 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_2 PF07650.15 T361218_3 - 1e-12 47.6 5.7 0.0024 17.6 0.5 3.6 3 1 0 3 3 3 3 KH domain KH_4 PF13083.4 T361218_3 - 5.3e-07 29.3 5.9 2e-05 24.2 0.0 3.0 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 T361218_3 - 0.0014 18.6 3.7 0.94 9.5 0.2 3.4 3 0 0 3 3 3 2 NusA-like KH domain Mre11_DNA_bind PF04152.12 T065954_2 - 3.1e-48 164.2 0.4 3.1e-48 164.2 0.4 2.0 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.26 T065954_2 - 1.4e-15 58.2 0.7 2.1e-15 57.6 0.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 T065954_2 - 0.00084 19.5 0.0 0.0083 16.2 0.0 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PK PF00224.19 T119074_1 - 2.3e-171 569.2 1.8 2.9e-171 568.9 1.8 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 T119074_1 - 4.4e-34 117.1 0.0 8.7e-34 116.1 0.0 1.5 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 T119074_1 - 0.0076 15.3 0.2 0.014 14.4 0.2 1.4 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Trypsin PF00089.24 T067575_1 - 1.7e-35 122.7 0.1 3.3e-35 121.8 0.1 1.4 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.4 T067575_1 - 3.3e-33 114.0 0.2 6.3e-33 113.1 0.2 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF1986 PF09342.9 T067575_1 - 0.00035 20.8 0.0 0.00066 19.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 T067575_1 - 0.013 16.2 0.0 0.025 15.3 0.0 1.4 1 0 0 1 1 1 0 Trypsin-like peptidase domain Trypsin PF00089.24 T067575_3 - 8.3e-29 100.8 0.0 1.2e-28 100.3 0.0 1.2 1 0 0 1 1 1 1 Trypsin C1-set PF07654.13 T212606_3 - 5.5e-25 87.5 4.4 1.6e-12 47.6 1.3 3.2 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Ig_3 PF13927.4 T212606_3 - 5.4e-21 74.9 6.9 9.7e-08 32.4 0.0 4.5 3 1 1 4 4 4 4 Immunoglobulin domain C2-set_2 PF08205.10 T212606_3 - 1.3e-18 66.7 12.6 1.1e-08 34.9 0.7 4.1 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.15 T212606_3 - 2.4e-16 59.7 0.1 1.2e-15 57.5 0.0 2.3 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.23 T212606_3 - 2.2e-13 50.0 10.2 3.6e-07 30.1 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.4 T212606_3 - 3e-13 49.8 3.0 0.0033 17.6 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T212606_3 - 3.4e-10 39.7 1.2 0.00056 19.8 0.0 4.1 3 1 1 4 4 4 3 Immunoglobulin I-set domain SIT PF15330.4 T212606_3 - 0.0017 18.6 0.1 0.0051 17.1 0.1 1.8 1 1 1 2 2 2 1 SHP2-interacting transmembrane adaptor protein, SIT DUF4448 PF14610.4 T212606_3 - 0.013 15.2 0.2 0.056 13.1 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4448) DUF912 PF06024.10 T212606_3 - 0.089 13.0 0.0 0.86 9.8 0.0 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Eryth_link_C PF16915.3 T212606_3 - 0.14 12.1 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Annelid erythrocruorin linker subunit C-terminus TMEM154 PF15102.4 T212606_3 - 7.4 6.3 8.2 0.62 9.8 0.0 2.2 2 0 0 2 2 2 0 TMEM154 protein family Furin-like_2 PF15913.3 T212337_3 - 1.2e-45 154.0 23.0 2.2e-45 153.1 23.0 1.4 1 0 0 1 1 1 1 Furin-like repeat, cysteine-rich GCV_T PF01571.19 T242505_3 - 4.3e-82 275.2 0.0 6.6e-82 274.6 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.9 T242505_3 - 1.1e-21 76.7 0.0 1.8e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain V-set_CD47 PF08204.9 T247675_2 - 3.6e-52 175.6 1.0 6.2e-52 174.9 1.0 1.4 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain CD47 PF04549.12 T247675_2 - 9.9e-52 174.9 25.3 2.4e-51 173.7 25.3 1.7 1 0 0 1 1 1 1 CD47 transmembrane region Mit_proteolip PF08039.9 T247675_3 - 0.68 10.2 4.4 1.8 8.8 4.4 1.7 1 0 0 1 1 1 0 Mitochondrial proteolipid WD40 PF00400.30 T007256_3 - 9.2e-22 76.8 1.4 2.8e-05 24.7 1.6 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T007256_3 - 5.2e-10 39.3 0.0 0.012 15.8 0.0 5.0 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T007256_3 - 0.0055 15.6 1.3 0.067 12.0 0.0 2.6 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Phosphodiest PF01663.20 T258857_1 - 2.4e-09 37.1 0.2 2.8e-07 30.3 0.2 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.16 T258857_1 - 0.043 13.0 0.0 0.063 12.5 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily Tim44 PF04280.13 T205561_1 - 0.012 15.5 0.1 0.026 14.5 0.1 1.4 1 0 0 1 1 1 0 Tim44-like domain MBA1 PF07961.9 T205561_1 - 0.019 13.9 0.1 0.029 13.3 0.1 1.2 1 0 0 1 1 1 0 MBA1-like protein UPF0565 PF10561.7 T205561_2 - 7.4e-05 22.0 0.0 9.9e-05 21.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0565 IPK PF03770.14 T242279_2 - 6.9e-61 205.4 0.0 1.1e-60 204.7 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Ion_trans_2 PF07885.14 T303065_1 - 1.1e-31 108.5 9.4 1.3e-16 60.2 0.4 3.5 3 0 0 3 3 3 3 Ion channel Ion_trans PF00520.29 T303065_1 - 0.0003 20.0 2.7 0.0015 17.7 0.6 2.4 2 0 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.14 T303065_3 - 2.2e-21 75.5 11.3 4.7e-13 48.8 6.4 2.5 2 0 0 2 2 2 2 Ion channel DUF1580 PF07618.9 T303065_3 - 0.042 13.3 0.1 0.1 12.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) zf-RING_2 PF13639.4 T061030_2 - 1.1e-10 41.5 8.4 2.9e-10 40.1 8.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.5 T061030_2 - 9.3e-09 35.3 6.0 2.7e-08 33.8 6.0 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 T061030_2 - 1.5e-07 31.1 7.5 3.4e-07 29.9 7.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T061030_2 - 5.1e-07 29.3 7.2 1.3e-06 28.0 7.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T061030_2 - 2.9e-05 23.7 5.5 8.2e-05 22.3 5.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T061030_2 - 3.1e-05 23.8 4.3 3.1e-05 23.8 4.3 2.1 2 0 0 2 2 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.3 T061030_2 - 6.5e-05 22.3 3.8 0.00017 21.0 3.8 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.4 T061030_2 - 0.00021 21.0 6.9 0.00061 19.6 6.9 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.3 T061030_2 - 0.00028 20.4 3.4 0.00028 20.4 3.4 2.1 2 0 0 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.4 T061030_2 - 0.00093 18.9 4.5 0.0022 17.7 4.5 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 FANCL_C PF11793.6 T061030_2 - 0.032 14.3 1.6 0.094 12.8 1.6 1.8 1 0 0 1 1 1 0 FANCL C-terminal domain zf-ANAPC11 PF12861.5 T061030_2 - 0.043 13.7 6.3 0.29 11.1 6.3 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.9 T061030_2 - 0.057 13.6 7.2 0.17 12.1 7.2 1.9 1 0 0 1 1 1 0 RING-like domain Zf_RING PF16744.3 T061030_2 - 0.12 12.3 3.1 0.31 11.1 3.1 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger zf-C3H2C3 PF17122.3 T061030_2 - 0.33 10.9 4.1 0.9 9.5 4.1 1.8 1 0 0 1 1 1 0 Zinc-finger Myosin_tail_1 PF01576.17 T117226_2 - 4.2e-52 177.1 178.2 3.2e-36 124.5 57.4 2.1 1 1 1 2 2 2 2 Myosin tail BLOC1_2 PF10046.7 T117226_2 - 0.0037 17.4 4.3 0.0037 17.4 4.3 8.7 3 3 7 10 10 10 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Abhydrolase_4 PF08386.8 T117226_2 - 0.039 14.0 0.7 0.5 10.4 0.5 2.6 2 0 0 2 2 2 0 TAP-like protein zf-H2C2_2 PF13465.4 T300075_3 - 1.4e-91 297.0 101.5 4.7e-09 36.1 0.3 15.0 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 T300075_3 - 1.9e-52 172.8 118.1 5.4e-06 26.5 0.1 15.0 14 0 0 14 14 14 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T300075_3 - 7.5e-25 85.3 123.6 0.0015 19.0 3.2 16.0 16 0 0 16 16 15 10 C2H2-type zinc finger KRAB PF01352.25 T300075_3 - 1.4e-23 82.1 0.3 3.2e-23 81.0 0.3 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T300075_3 - 1.5e-19 69.3 92.2 0.00011 21.9 0.2 14.8 14 0 0 14 14 14 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T300075_3 - 3.3e-07 30.2 76.6 0.015 15.3 1.9 9.6 5 2 6 11 11 11 7 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T300075_3 - 2.4e-05 24.4 57.8 0.094 12.9 0.0 11.5 12 1 1 13 13 13 5 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T300075_3 - 0.0011 18.5 74.5 0.1 12.2 0.1 13.2 14 0 0 14 14 14 5 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 T300075_3 - 0.033 14.8 65.2 0.82 10.3 0.9 7.9 1 1 7 8 8 8 0 zinc-ribbon family XPA_N PF01286.16 T300075_3 - 0.84 9.6 62.5 3.5 7.6 0.4 13.3 14 0 0 14 14 14 0 XPA protein N-terminal DUF3268 PF11672.6 T300075_3 - 2.5 8.3 47.1 0.7 10.1 0.9 7.3 5 2 3 8 8 8 0 zinc-finger-containing domain LRR_8 PF13855.4 T329719_1 - 4.1e-22 77.6 12.6 1.9e-09 37.0 1.2 4.0 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 T329719_1 - 1.4e-12 47.4 17.6 4.4e-05 23.6 2.6 4.5 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 T329719_1 - 0.31 11.1 10.4 20 5.4 0.4 5.1 5 0 0 5 5 5 0 Leucine Rich repeat SAP25 PF15476.4 T329719_2 - 8.9e-103 342.1 16.8 8.9e-103 342.1 16.8 2.6 2 0 0 2 2 2 1 Histone deacetylase complex subunit SAP25 CH PF00307.29 T329719_3 - 2.2e-13 50.2 0.0 3.5e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 T329719_3 - 0.0054 16.4 0.0 0.0088 15.7 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain OLF PF02191.14 T023968_2 - 2.7e-84 282.5 10.2 3.6e-84 282.1 10.2 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.6 T023968_2 - 0.0048 16.7 2.9 0.0081 16.0 0.1 2.4 2 0 0 2 2 2 1 Neurogenesis glycoprotein Fib_alpha PF08702.8 T023968_2 - 0.15 12.1 2.8 0.59 10.2 2.2 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ASFV_J13L PF05568.9 T023968_2 - 7.3 6.2 11.0 22 4.6 0.0 2.4 2 0 0 2 2 2 0 African swine fever virus J13L protein Ras PF00071.20 T022238_2 - 1.4e-49 167.7 0.0 1.9e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T022238_2 - 8.1e-17 61.4 0.0 1.3e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T022238_2 - 1.8e-07 30.6 0.0 2.6e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SOGA PF11365.6 T311133_1 - 1.9e-60 201.9 49.5 1.9e-30 105.7 1.1 5.1 3 1 1 4 4 4 3 Protein SOGA DUF4482 PF14818.4 T311133_1 - 3.3e-47 160.7 11.7 3.3e-47 160.7 11.7 4.9 5 0 0 5 5 5 1 Domain of unknown function (DUF4482) TSC22 PF01166.16 T311133_1 - 0.5 10.6 37.6 0.087 13.0 0.4 6.3 6 0 0 6 6 6 0 TSC-22/dip/bun family SH3_1 PF00018.26 T143532_1 - 9.4e-16 57.0 0.0 2e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH2 PF00017.22 T143532_1 - 4e-11 42.7 0.1 6.3e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.4 T143532_1 - 6.6e-11 41.8 0.0 1.3e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T143532_1 - 5.8e-08 32.2 0.0 1.9e-07 30.5 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 T143532_1 - 0.1 12.7 0.0 0.27 11.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain Pou PF00157.15 T176152_1 - 3.6e-37 126.1 0.2 6e-37 125.4 0.2 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 T176152_1 - 7.3e-16 57.6 3.7 1.4e-15 56.7 3.7 1.5 1 0 0 1 1 1 1 Homeobox domain Suf PF05843.12 T176152_3 - 8.4 6.1 11.3 14 5.4 11.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UDPGT PF00201.16 T209953_2 - 6.6e-242 803.6 0.3 7.8e-242 803.3 0.3 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 T209953_2 - 1.4e-08 34.8 0.0 2.5e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Ion_trans PF00520.29 T071574_2 - 5.8e-251 827.9 78.3 9.2e-71 237.8 18.5 4.3 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 T071574_2 - 4.6e-37 128.4 12.3 7.1e-27 94.9 0.0 3.0 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 T071574_2 - 5.7e-36 122.0 0.0 1.2e-35 121.0 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 T071574_2 - 5.4e-30 103.4 0.1 1.1e-29 102.4 0.1 1.5 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 T071574_2 - 1.4e-09 37.1 31.7 1.1e-08 34.1 8.8 7.7 7 2 1 8 8 8 3 Polycystin cation channel cwf18 PF08315.10 T241873_3 - 3.6e-36 124.7 22.0 6.3e-36 123.9 22.0 1.4 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor z-alpha PF02295.15 T220742_1 - 0.00037 20.3 0.0 0.001 18.9 0.0 1.7 1 0 0 1 1 1 1 Adenosine deaminase z-alpha domain RHIM PF12721.5 T220742_1 - 1.7 9.1 13.2 0.075 13.4 5.4 2.8 3 0 0 3 3 3 0 RIP homotypic interaction motif Cyclin_N PF00134.21 T382191_3 - 1.6e-10 40.7 0.1 5.5e-09 35.7 0.0 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Synuclein PF01387.15 T294112_1 - 2.6e-48 163.5 10.1 5.5e-48 162.4 10.1 1.5 1 1 0 1 1 1 1 Synuclein DDE_1 PF03184.17 T020874_2 - 1.8e-11 43.8 0.0 3.3e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 T020874_2 - 8.6e-09 35.2 0.1 2.2e-08 33.9 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_28 PF13518.4 T020874_2 - 0.011 15.8 0.2 0.02 14.9 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain FYVE PF01363.19 T020874_2 - 0.042 13.9 0.1 0.042 13.9 0.1 5.2 4 2 1 5 5 5 0 FYVE zinc finger zf-C2H2_4 PF13894.4 T020874_2 - 0.11 13.3 71.9 0.43 11.4 0.5 10.7 10 0 0 10 10 10 0 C2H2-type zinc finger zf-RRN7 PF11781.6 T020874_2 - 0.23 11.0 5.7 5 6.8 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Ku_N PF03731.13 T234346_2 - 1.1e-78 263.8 1.6 2.1e-78 262.9 1.6 1.5 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.14 T234346_2 - 3e-49 167.3 0.1 5.3e-49 166.5 0.1 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.12 T234346_2 - 2.2e-28 98.6 0.1 7.2e-28 97.0 0.1 1.9 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm SAP PF02037.25 T234346_2 - 1.8e-09 37.0 0.1 4e-09 35.9 0.1 1.7 1 0 0 1 1 1 1 SAP domain SAP30_Sin3_bdg PF13867.4 T234346_2 - 0.015 15.5 0.0 0.087 13.0 0.0 2.3 2 0 0 2 2 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 ocr PF08684.8 T234346_2 - 0.13 12.6 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 DNA mimic ocr Fucokinase PF07959.10 T135477_1 - 3.2e-95 319.4 0.0 4.3e-95 319.0 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase GHMP_kinases_C PF08544.11 T135477_2 - 1.8e-05 24.8 0.0 3.9e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.24 T135477_2 - 3.8e-05 23.7 0.2 9.9e-05 22.4 0.2 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain PX PF00787.22 T218678_3 - 1.9e-13 50.3 0.0 3.6e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 PX domain TPR_1 PF00515.26 T218678_3 - 0.00018 21.1 0.2 0.00063 19.3 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 T218678_3 - 0.00038 20.2 1.1 0.0042 17.0 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 T218678_3 - 0.00057 20.0 0.6 0.0018 18.4 0.6 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.4 T218678_3 - 0.046 13.6 0.2 0.2 11.6 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.4 T218678_3 - 0.078 13.4 0.4 0.19 12.1 0.4 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.4 T218678_3 - 0.12 12.1 1.2 0.8 9.6 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 T218678_3 - 0.14 12.3 0.0 0.4 10.9 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Arf PF00025.19 T146656_1 - 0.00024 20.5 0.1 0.00034 20.0 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Arf PF00025.19 T146656_2 - 7.6e-38 129.6 0.1 1.1e-37 129.0 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 T146656_2 - 0.0027 17.2 0.0 0.0043 16.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T146656_2 - 0.028 14.5 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Atrophin-1 PF03154.13 T146656_2 - 0.065 11.4 10.5 0.093 10.9 10.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 T146656_2 - 0.13 12.1 6.6 0.35 10.7 6.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF4619 PF15398.4 T105023_1 - 7.7e-53 179.8 0.1 1e-52 179.4 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4619) DUF3704 PF12488.6 T105023_1 - 0.28 10.7 1.6 0.9 9.1 1.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) DUF4619 PF15398.4 T105023_2 - 5.2e-89 298.5 14.8 1.3e-49 169.2 8.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4619) Xlink PF00193.15 T121678_1 - 1.7e-123 403.2 4.9 5.7e-32 109.8 0.1 4.8 5 0 0 5 5 5 4 Extracellular link domain Lectin_C PF00059.19 T121678_1 - 8e-23 81.1 12.0 1.2e-19 70.9 1.5 4.9 5 0 0 5 5 5 2 Lectin C-type domain EGF PF00008.25 T121678_1 - 1.9e-11 43.9 16.8 4.9e-06 26.6 1.1 3.6 2 0 0 2 2 2 2 EGF-like domain V-set PF07686.15 T121678_1 - 7.5e-11 42.0 0.0 3.5e-10 39.9 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain Sushi PF00084.18 T121678_1 - 1.4e-08 35.1 1.6 1.4e-08 35.1 1.6 2.0 2 0 0 2 2 1 1 Sushi repeat (SCR repeat) hEGF PF12661.5 T121678_1 - 0.0001 22.7 0.9 0.0001 22.7 0.9 3.8 4 0 0 4 4 2 2 Human growth factor-like EGF EGF_CA PF07645.13 T121678_1 - 0.0033 17.5 5.5 0.0033 17.5 5.5 3.6 3 1 0 3 3 3 1 Calcium-binding EGF domain EGF_2 PF07974.11 T121678_1 - 0.0058 16.9 18.1 0.018 15.3 8.0 3.1 2 0 0 2 2 2 1 EGF-like domain I-set PF07679.14 T121678_1 - 0.011 15.7 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.23 T121678_1 - 0.012 15.7 0.0 0.033 14.2 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin domain Antimicrobial25 PF16839.3 T121678_1 - 0.025 14.5 2.8 0.074 13.0 2.8 1.7 1 0 0 1 1 1 0 Nematode antimicrobial peptide EGF_3 PF12947.5 T121678_1 - 0.57 10.3 16.0 0.68 10.0 0.2 2.9 3 0 0 3 3 2 0 EGF domain cEGF PF12662.5 T121678_1 - 1.7 8.5 8.0 0.26 11.1 1.6 2.9 2 0 0 2 2 2 0 Complement Clr-like EGF-like FXa_inhibition PF14670.4 T121678_1 - 5.7 7.2 15.9 3.2 8.0 5.6 2.7 1 1 1 2 2 2 0 Coagulation Factor Xa inhibitory site ILEI PF15711.3 T332116_3 - 4e-27 94.4 0.0 6.6e-27 93.7 0.0 1.4 1 0 0 1 1 1 1 Interleukin-like EMT inducer Collagen PF01391.16 T301804_1 - 1.2e-150 489.2 710.8 1e-08 34.7 27.5 23.7 5 1 11 16 16 16 8 Collagen triple helix repeat (20 copies) COLFI PF01410.16 T301804_1 - 3.5e-58 196.5 0.0 2.8e-34 118.3 0.1 2.1 1 1 1 2 2 2 2 Fibrillar collagen C-terminal domain Laminin_G_2 PF02210.22 T301804_1 - 3.7e-07 30.6 0.0 6.4e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.4 T301804_1 - 0.00041 20.4 0.0 0.00064 19.8 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.21 T301804_1 - 0.011 15.8 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain Hormone_recep PF00104.28 T301804_2 - 2.3e-38 131.8 0.0 3.3e-38 131.2 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 T301804_2 - 7.5e-31 106.3 16.7 1.4e-30 105.4 16.7 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Nuc_recep-AF1 PF11825.6 T301804_2 - 3.2e-05 23.8 11.8 3.2e-05 23.8 11.8 1.8 2 0 0 2 2 2 1 Nuclear/hormone receptor activator site AF-1 Pkinase PF00069.23 T372132_2 - 6.4e-28 97.7 0.4 5.3e-20 71.8 0.1 3.4 2 1 1 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.15 T372132_2 - 3e-16 59.4 0.1 2.8e-13 49.6 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase KSR1-SAM PF13543.4 T372132_2 - 4.9e-05 23.3 0.4 0.00011 22.2 0.4 1.6 1 0 0 1 1 1 1 SAM like domain present in kinase suppressor RAS 1 MCM_N PF14551.4 T372132_2 - 0.091 13.2 1.4 0.28 11.7 1.1 1.9 1 1 1 2 2 2 0 MCM N-terminal domain SLIDE PF09111.8 T372132_2 - 0.15 11.9 0.9 0.36 10.7 0.3 1.8 2 0 0 2 2 2 0 SLIDE CENP-T_N PF16171.3 T134877_1 - 7.9e-160 531.7 18.9 1e-159 531.4 18.9 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T N-terminus CENP-T_C PF15511.4 T134877_2 - 1.3e-35 121.6 0.1 1.9e-35 121.1 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-T_N PF16171.3 T134877_2 - 7.5e-18 64.4 5.9 7.5e-18 64.4 5.9 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T N-terminus CENP-S PF15630.4 T134877_2 - 5.6e-09 36.1 0.0 9.5e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.21 T134877_2 - 0.003 17.7 0.1 0.0054 16.9 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.11 T134877_2 - 0.0036 17.2 0.0 0.0056 16.5 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.22 T134877_2 - 0.0081 16.4 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.14 T134877_2 - 0.082 12.8 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit PfkB PF00294.22 T186614_1 - 1.9e-30 106.1 0.0 3.5e-19 69.1 0.0 2.1 1 1 1 2 2 2 2 pfkB family carbohydrate kinase EMI PF07546.11 T186614_2 - 3.2e-14 53.3 10.0 9.7e-14 51.7 10.0 1.9 1 0 0 1 1 1 1 EMI domain C1q PF00386.19 T186614_2 - 2.1e-10 40.8 0.0 7.2e-10 39.0 0.0 1.8 1 1 0 1 1 1 1 C1q domain Collagen PF01391.16 T186614_2 - 2.8e-08 33.3 28.4 2.8e-08 33.3 28.4 3.9 4 0 0 4 4 1 1 Collagen triple helix repeat (20 copies) DUF1664 PF07889.10 T186614_2 - 0.094 12.6 2.6 23 4.9 0.4 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) FlxA PF14282.4 T186614_2 - 0.24 11.3 3.4 2.6 8.0 0.0 2.9 3 0 0 3 3 3 0 FlxA-like protein Spc7 PF08317.9 T186614_2 - 0.31 9.7 6.6 0.67 8.6 0.1 2.9 4 0 0 4 4 4 0 Spc7 kinetochore protein HAUS-augmin3 PF14932.4 T186614_2 - 0.39 10.1 2.4 1.7 8.0 0.5 2.4 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Reo_sigmaC PF04582.10 T186614_2 - 0.54 9.5 4.8 1.9 7.7 0.5 3.1 3 1 1 4 4 4 0 Reovirus sigma C capsid protein COG2 PF06148.9 T186614_2 - 1.7 8.6 3.6 50 3.9 0.0 3.6 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 WXG100 PF06013.10 T186614_2 - 1.8 8.7 4.5 52 4.0 1.1 3.3 2 0 0 2 2 2 0 Proteins of 100 residues with WXG TRAF_BIRC3_bd PF16673.3 T186614_2 - 2.2 8.0 4.4 46 3.8 0.3 3.9 4 0 0 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain DUF4407 PF14362.4 T186614_2 - 4.6 6.4 11.1 8 5.6 0.8 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) Filament PF00038.19 T186614_2 - 5 6.5 6.0 9.1 5.6 1.0 2.3 2 0 0 2 2 2 0 Intermediate filament protein Lectin_C PF00059.19 T183469_2 - 3.6e-15 56.5 0.0 6.8e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 T183469_2 - 1.1e-08 34.5 12.5 2.4e-08 33.5 12.5 1.5 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Transposase_22 PF02994.12 T010879_1 - 0.0011 17.8 0.1 0.0015 17.3 0.1 1.1 1 0 0 1 1 1 1 L1 transposable element Ank_5 PF13857.4 T010879_2 - 7.4e-16 57.9 2.8 1.2e-08 34.9 0.2 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 T010879_2 - 2.7e-15 56.6 1.2 1.3e-07 32.0 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T010879_2 - 7e-15 55.0 0.4 9.1e-08 32.4 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.28 T010879_2 - 9.2e-08 32.1 5.2 0.0052 17.1 0.1 5.2 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.4 T010879_2 - 7.3e-06 25.8 0.1 0.08 13.4 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat CDC45 PF02724.12 T098736_1 - 0.48 8.5 3.4 0.66 8.1 3.4 1.3 1 0 0 1 1 1 0 CDC45-like protein Cytomega_UL84 PF06284.9 T098736_1 - 0.51 8.6 6.7 0.96 7.7 6.7 1.4 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein eIF3_subunit PF08597.8 T098736_1 - 8 6.2 15.5 2.7 7.7 9.6 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit DUF2722 PF10846.6 T098736_3 - 0.0023 16.8 6.4 0.0035 16.2 6.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.6 T098736_3 - 0.076 12.5 16.0 0.12 11.8 16.0 1.2 1 0 0 1 1 1 0 Spt20 family PaO PF08417.10 T098736_3 - 0.17 11.9 0.1 0.17 11.9 0.1 1.7 2 0 0 2 2 2 0 Pheophorbide a oxygenase Hydin_ADK PF17213.1 T098736_3 - 0.17 12.0 1.7 0.41 10.8 1.7 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain TFIIA PF03153.11 T098736_3 - 1.1 9.1 15.0 1.8 8.3 15.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Connexin PF00029.17 T098736_3 - 8.2 6.0 5.9 1 9.0 1.2 1.8 2 0 0 2 2 2 0 Connexin 7tm_4 PF13853.4 T167784_3 - 1.3e-46 159.4 17.5 2e-46 158.8 17.5 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T167784_3 - 9.4e-25 87.2 15.6 9.4e-25 87.2 15.6 2.2 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T167784_3 - 8.1e-07 28.5 15.1 1.4e-06 27.7 15.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CATSPERB PF15149.4 T109020_3 - 2.2e-230 765.5 2.6 5e-132 441.0 0.7 2.1 1 1 1 2 2 2 2 Cation channel sperm-associated protein subunit beta protein family C2 PF00168.28 T109020_3 - 4.7e-09 36.3 0.1 5.6e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 C2 domain Peptidase_M1 PF01433.18 T286403_2 - 2.5e-131 438.4 0.0 3.4e-131 438.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.6 T286403_2 - 4.6e-69 233.2 0.1 6.8e-69 232.7 0.1 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain BACK PF07707.13 T255806_2 - 8.2e-32 109.2 0.3 1.5e-31 108.4 0.3 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 T255806_2 - 1.2e-25 89.8 3.6 2e-25 89.0 2.4 1.9 1 1 1 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.23 T255806_2 - 3.1e-21 74.5 7.2 4.2e-09 35.7 0.4 4.5 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.4 T255806_2 - 1.9e-13 50.0 3.1 0.00044 20.3 0.0 4.1 3 1 1 4 4 4 3 Kelch motif Kelch_2 PF07646.13 T255806_2 - 2.8e-13 49.1 7.1 5.8e-05 22.8 0.4 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.4 T255806_2 - 5.3e-07 29.4 0.7 0.00099 18.9 0.1 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.4 T255806_2 - 2.2e-06 27.7 0.5 0.37 11.0 0.0 3.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.4 T255806_2 - 0.00044 20.0 0.5 0.67 9.8 0.0 3.6 4 0 0 4 4 4 2 Galactose oxidase, central domain DUF3342 PF11822.6 T255806_2 - 0.018 15.1 1.3 0.066 13.3 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Kelch_1 PF01344.23 T255806_3 - 8e-05 22.0 0.0 0.00074 18.9 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.13 T255806_3 - 0.011 15.5 0.0 0.039 13.8 0.0 2.0 1 0 0 1 1 1 0 Kelch motif Kelch_6 PF13964.4 T255806_3 - 0.048 13.8 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Kelch motif Ig_3 PF13927.4 T087376_1 - 1.6e-29 102.2 2.6 1.7e-10 41.2 0.1 4.7 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 T087376_1 - 2.1e-21 75.6 0.0 6e-10 38.9 0.0 3.7 4 0 0 4 4 4 3 Immunoglobulin I-set domain ig PF00047.23 T087376_1 - 4.1e-18 65.2 0.7 2.6e-05 24.1 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.4 T087376_1 - 2.9e-16 59.4 1.5 0.0023 18.1 0.1 4.6 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 T087376_1 - 1.5e-13 50.7 0.8 1.3e-06 28.3 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 T087376_1 - 1.9e-06 27.7 1.0 0.025 14.5 0.0 4.4 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 T087376_1 - 0.012 15.8 1.1 0.21 11.9 0.0 3.2 4 0 0 4 4 4 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.13 T087376_1 - 0.11 12.8 0.0 0.78 10.1 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin C1-set domain WD40 PF00400.30 T087376_2 - 3.9e-32 109.6 18.6 1.1e-06 29.1 0.1 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat SOCS_box PF07525.14 T087376_2 - 4.3e-08 33.3 0.4 1.3e-07 31.7 0.4 1.9 1 0 0 1 1 1 1 SOCS box ANAPC4_WD40 PF12894.5 T087376_2 - 0.00023 21.3 0.0 6.1 7.1 0.0 4.4 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T087376_2 - 0.011 14.6 0.1 9.8 4.9 0.0 3.5 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1220 PF06758.11 T019290_3 - 1.1e-59 198.5 27.7 9.4e-23 80.2 7.7 3.5 3 0 0 3 3 3 3 Repeat of unknown function (DUF1220) EGF PF00008.25 T019290_3 - 8.4e-29 99.4 81.5 2.8e-07 30.6 5.3 7.2 6 0 0 6 6 6 6 EGF-like domain EGF_CA PF07645.13 T019290_3 - 7e-08 32.4 6.2 7e-08 32.4 6.2 6.7 3 1 3 6 6 6 1 Calcium-binding EGF domain hEGF PF12661.5 T019290_3 - 3.7e-06 27.3 90.3 1.3e-05 25.5 6.4 8.7 7 1 0 7 7 7 5 Human growth factor-like EGF GAT PF03127.12 T019290_3 - 0.00068 19.8 8.5 0.1 12.8 1.0 2.5 2 0 0 2 2 2 2 GAT domain Ras PF00071.20 T282860_1 - 2.7e-59 199.2 1.8 3.8e-59 198.8 1.8 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T282860_1 - 2.2e-31 108.4 1.1 3.3e-31 107.9 1.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T282860_1 - 1.6e-12 47.1 0.2 2.4e-12 46.5 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 T282860_1 - 0.0033 16.8 0.2 0.0088 15.4 0.0 1.6 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 T282860_1 - 0.011 15.6 0.1 0.017 15.1 0.1 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.25 T282860_1 - 0.018 14.5 0.1 0.03 13.7 0.1 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF2757 PF10955.6 T282860_1 - 0.24 11.6 2.4 0.17 12.0 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2757) TPR_1 PF00515.26 T043877_1 - 1e-06 28.1 11.4 0.0033 17.1 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.15 T043877_1 - 5.3e-06 26.0 13.8 0.16 12.0 2.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 T043877_1 - 2.6e-05 23.9 10.3 0.021 14.9 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.4 T043877_1 - 0.00052 20.3 7.9 0.042 14.2 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.4 T043877_1 - 0.0052 17.4 3.5 3.5 8.6 1.1 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 T043877_1 - 0.017 15.7 2.3 4.5 7.9 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.4 T043877_1 - 0.037 13.9 2.0 10 6.3 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 T043877_1 - 0.39 10.9 10.1 0.37 11.0 1.5 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.4 T043877_1 - 1.2 9.5 3.6 7.5 7.1 0.4 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 T043877_1 - 1.7 8.7 10.1 0.61 10.2 1.6 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Ribosomal_S16 PF00886.17 T043877_2 - 5e-21 74.3 0.0 9.7e-21 73.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S16 DnaJ PF00226.29 T043877_3 - 1.8e-16 59.8 0.0 3.1e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain TPR_12 PF13424.4 T043877_3 - 0.0057 16.8 0.4 0.014 15.5 0.4 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.4 T043877_3 - 0.006 17.2 0.5 11 7.0 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 T043877_3 - 0.029 14.4 0.4 7.6 6.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 T043877_3 - 0.078 12.7 4.1 1.6 8.6 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.5 T043877_3 - 0.11 12.6 2.2 0.2 11.8 2.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.15 T043877_3 - 0.11 12.5 1.8 3 8.0 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.4 T043877_3 - 0.16 12.3 1.0 2.8 8.4 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Mob1_phocein PF03637.15 T010341_2 - 3.3e-73 245.1 0.0 5e-73 244.5 0.0 1.3 1 0 0 1 1 1 1 Mob1/phocein family Pkinase PF00069.23 T010341_2 - 3e-66 223.4 0.0 4.3e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T010341_2 - 1.9e-28 99.3 0.0 2.8e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 T010341_2 - 4.2e-06 26.1 0.0 6.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RRN7 PF11781.6 T010341_2 - 0.0046 16.5 0.2 0.016 14.8 0.2 2.0 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 APH PF01636.21 T010341_2 - 0.051 13.3 0.3 0.12 12.1 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Peptidase_M28 PF04389.15 T355309_2 - 4.1e-46 157.0 0.0 5.7e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Bromodomain PF00439.23 T355309_2 - 0.00044 20.1 0.2 0.0012 18.8 0.0 1.8 2 0 0 2 2 2 1 Bromodomain Peptidase_M20 PF01546.26 T355309_2 - 0.067 12.8 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 NEXCaM_BD PF16644.3 T355309_2 - 2.4 8.3 9.3 5.1 7.2 9.3 1.5 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin HEAT_2 PF13646.4 T355309_3 - 9e-10 38.7 0.0 0.0014 18.8 0.0 3.2 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.20 T355309_3 - 1.3e-09 37.3 0.0 0.0018 18.2 0.0 3.2 2 0 0 2 2 2 2 HEAT repeat HEAT_EZ PF13513.4 T355309_3 - 6.1e-06 26.4 0.0 0.1 12.9 0.0 3.5 3 1 1 4 4 4 3 HEAT-like repeat Cnd1 PF12717.5 T355309_3 - 0.00059 19.7 0.2 0.78 9.6 0.2 2.3 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 p450 PF00067.20 T046391_2 - 1.7e-162 541.3 0.0 2e-162 541.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Arm PF00514.21 T240783_3 - 3.3e-37 125.3 19.1 3.2e-07 30.0 0.1 11.0 12 0 0 12 12 12 6 Armadillo/beta-catenin-like repeat Cnd1 PF12717.5 T240783_3 - 5.5e-07 29.6 1.8 0.014 15.3 0.4 4.0 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.18 T240783_3 - 7.2e-05 21.4 1.9 0.0037 15.8 0.9 2.8 3 0 0 3 3 3 1 Adaptin N terminal region HEAT_2 PF13646.4 T240783_3 - 0.00025 21.2 5.3 0.11 12.8 0.2 4.3 5 0 0 5 5 5 1 HEAT repeats HEAT PF02985.20 T240783_3 - 0.00079 19.3 1.7 58 4.2 0.0 5.4 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.4 T240783_3 - 0.00086 19.6 7.4 3.7 8.0 0.0 5.6 5 1 1 6 6 6 1 HEAT-like repeat Atx10homo_assoc PF09759.7 T240783_3 - 0.012 15.5 0.8 0.04 13.9 0.1 2.3 2 1 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain RasGEF_N_2 PF14663.4 T240783_3 - 0.033 14.4 2.3 19 5.5 0.0 4.0 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF3361 PF11841.6 T240783_3 - 0.043 13.6 0.8 6.9 6.5 0.0 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3361) Queuosine_synth PF02547.13 T240783_3 - 0.077 12.0 0.1 0.14 11.1 0.1 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein Arm_2 PF04826.11 T240783_3 - 0.29 10.4 2.3 2.6 7.3 0.0 2.8 2 1 1 3 3 3 0 Armadillo-like LRR_8 PF13855.4 T381149_1 - 4.3e-41 138.4 45.2 5.5e-16 57.9 1.2 6.4 2 2 5 7 7 7 6 Leucine rich repeat LRR_4 PF12799.5 T381149_1 - 5e-13 48.8 49.5 0.00017 21.8 0.6 8.5 8 1 0 9 9 9 6 Leucine Rich repeats (2 copies) LRRNT PF01462.16 T381149_1 - 0.0034 16.9 2.3 0.0034 16.9 2.3 3.2 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 T381149_1 - 0.016 14.6 12.0 0.4 10.0 0.2 3.8 2 2 2 4 4 4 0 Leucine-rich repeat LRR_1 PF00560.31 T381149_1 - 0.53 10.8 32.4 8.8 7.1 0.0 10.0 10 1 0 10 10 10 0 Leucine Rich Repeat Bcl-2 PF00452.17 T101343_1 - 1.7e-28 99.0 0.2 2.7e-28 98.3 0.2 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.15 T101343_1 - 2.7e-10 39.7 0.0 5.7e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 Bcl-2 homology region 4 RRM_1 PF00076.20 T101343_2 - 5.1e-14 51.7 0.0 8e-14 51.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cadherin PF00028.15 T291657_1 - 0 1329.1 21.1 7.2e-23 80.7 0.0 28.2 28 0 0 28 28 28 28 Cadherin domain Cadherin_2 PF08266.10 T291657_1 - 1.3e-21 76.0 0.0 0.04 13.6 0.0 15.2 18 0 0 18 18 18 4 Cadherin-like Laminin_G_2 PF02210.22 T291657_1 - 2.6e-18 66.7 0.0 1.2e-17 64.6 0.0 2.2 2 0 0 2 2 2 1 Laminin G domain Laminin_G_1 PF00054.21 T291657_1 - 1.8e-08 34.5 0.0 4.5e-08 33.2 0.0 1.8 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.25 T291657_1 - 2.6e-06 27.5 23.6 7.3e-05 22.8 7.1 4.0 5 0 0 5 5 5 2 EGF-like domain EGF_2 PF07974.11 T291657_1 - 6 7.2 37.3 0.026 14.8 12.8 3.9 3 0 0 3 3 3 0 EGF-like domain Cadherin PF00028.15 T291657_2 - 2e-38 130.6 0.0 4.9e-13 49.2 0.0 4.3 4 0 0 4 4 4 4 Cadherin domain DPM3 PF08285.9 T021881_3 - 3.8e-30 103.8 0.0 4.5e-30 103.5 0.0 1.1 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) NACHT PF05729.10 T181055_2 - 1.2e-41 142.2 0.0 2.6e-41 141.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain LRR_6 PF13516.4 T181055_2 - 1.3e-05 24.8 20.7 0.16 12.0 0.0 7.5 8 0 0 8 8 8 3 Leucine Rich repeat AAA PF00004.27 T181055_2 - 0.016 15.5 0.0 0.029 14.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 T181055_2 - 0.021 15.1 3.8 0.028 14.6 0.3 2.5 2 1 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.20 T181055_2 - 0.027 13.3 0.0 0.065 12.1 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain LRR_4 PF12799.5 T181055_2 - 0.029 14.6 21.6 3.1 8.2 0.8 6.5 4 3 4 8 8 8 0 Leucine Rich repeats (2 copies) AAA_22 PF13401.4 T181055_2 - 0.03 14.5 0.4 0.12 12.5 0.2 2.2 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.4 T181055_2 - 0.11 12.5 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 T181055_2 - 0.14 11.8 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.12 T181055_2 - 0.16 11.0 0.1 14 4.7 0.0 2.2 1 1 0 2 2 2 0 KAP family P-loop domain PYRIN PF02758.14 T181055_3 - 5.1e-19 68.1 1.8 7.8e-19 67.5 1.8 1.3 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain Oxysterol_BP PF01237.16 T010998_3 - 5.4e-81 272.1 8.3 5e-79 265.7 8.3 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein Snapin_Pallidin PF14712.4 T010998_3 - 0.053 13.8 0.4 0.053 13.8 0.4 1.6 2 0 0 2 2 2 0 Snapin/Pallidin Pkinase PF00069.23 T152147_1 - 5.1e-35 121.0 0.0 7.1e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T152147_1 - 1.2e-22 80.3 0.0 3e-21 75.7 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase HGWP PF03578.13 T152147_1 - 0.022 14.3 3.8 0.079 12.5 3.8 2.0 1 0 0 1 1 1 0 HGWP repeat LIM PF00412.20 T152147_3 - 4.9e-09 36.2 9.9 4.9e-09 36.2 9.9 2.5 2 0 0 2 2 2 1 LIM domain dUTPase PF00692.17 T347742_2 - 0.0013 18.3 0.0 0.0022 17.5 0.0 1.3 1 0 0 1 1 1 1 dUTPase DUF863 PF05904.9 T302157_3 - 2 6.6 6.5 2.8 6.1 6.5 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF863) Arfaptin PF06456.11 T054014_1 - 5.2e-70 235.4 1.4 6.8e-70 235.1 1.4 1.1 1 0 0 1 1 1 1 Arfaptin-like domain BAR PF03114.16 T054014_1 - 0.0018 17.8 1.2 0.0029 17.2 1.2 1.2 1 0 0 1 1 1 1 BAR domain Arfaptin PF06456.11 T054014_3 - 0.0069 15.8 0.2 0.0085 15.5 0.2 1.1 1 0 0 1 1 1 1 Arfaptin-like domain B56 PF01603.18 T110606_2 - 8.4e-200 663.9 11.2 1e-199 663.6 11.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) TROVE PF05731.9 T100346_1 - 1.6e-133 445.5 1.6 2.1e-133 445.0 1.6 1.2 1 0 0 1 1 1 1 TROVE domain TEP1_N PF05386.9 T100346_1 - 9.7e-77 252.0 22.4 5.6e-20 70.5 1.0 4.8 4 0 0 4 4 4 4 TEP1 N-terminal domain WD40 PF00400.30 T100346_1 - 2.6e-38 129.2 36.2 8.9e-06 26.2 0.2 18.0 18 0 0 18 18 18 7 WD domain, G-beta repeat NACHT PF05729.10 T100346_1 - 2.1e-36 125.2 0.1 4.6e-36 124.1 0.1 1.6 1 0 0 1 1 1 1 NACHT domain DUF4062 PF13271.4 T100346_1 - 2.2e-18 66.2 0.0 4.7e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) ANAPC4_WD40 PF12894.5 T100346_1 - 2.8e-15 56.2 0.0 0.39 10.9 0.0 8.7 7 2 2 9 9 8 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T100346_1 - 1.7e-05 23.8 0.0 1.6 7.5 0.0 4.9 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.3 T100346_1 - 5.4e-05 22.5 0.0 0.0082 15.4 0.0 2.8 3 0 0 3 3 3 1 WD40-like domain AAA_16 PF13191.4 T100346_1 - 5.9e-05 23.4 0.3 0.00022 21.5 0.3 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 T100346_1 - 6.2e-05 23.2 0.0 0.00015 21.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Nup160 PF11715.6 T100346_1 - 0.0018 16.8 1.0 0.43 9.0 0.0 2.8 4 0 0 4 4 4 2 Nucleoporin Nup120/160 PQQ_3 PF13570.4 T100346_1 - 0.0077 16.6 1.8 3 8.3 0.2 4.0 3 0 0 3 3 3 1 PQQ-like domain AAA_25 PF13481.4 T100346_1 - 0.028 13.9 0.0 0.068 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 T100346_1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 T100346_1 - 0.14 11.8 0.1 0.29 10.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.4 T100346_1 - 0.18 12.0 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Forkhead PF00250.16 T102330_2 - 3.4e-38 129.7 0.1 7.7e-38 128.6 0.1 1.6 1 0 0 1 1 1 1 Forkhead domain SelP_N PF04592.12 T102330_2 - 2.6 7.3 17.8 5.7 6.1 17.8 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Cadherin PF00028.15 T242659_1 - 0.031 14.6 0.0 0.57 10.5 0.0 2.3 2 0 0 2 2 2 0 Cadherin domain Cadherin PF00028.15 T242659_2 - 8.6e-08 32.4 0.0 5.3e-05 23.5 0.0 2.2 2 0 0 2 2 2 2 Cadherin domain Cadherin PF00028.15 T242659_3 - 2.1e-15 56.8 0.0 6.4e-14 52.0 0.0 2.3 2 0 0 2 2 2 1 Cadherin domain zf-DHHC PF01529.18 T082748_3 - 1.3e-31 109.4 18.7 1.3e-31 109.4 18.7 2.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.5 T082748_3 - 7.9e-30 103.2 0.2 9.5e-16 58.0 0.2 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T082748_3 - 3.6e-26 91.0 0.8 3.6e-08 33.7 0.0 4.1 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 T082748_3 - 2.2e-24 82.7 2.1 0.00028 21.0 0.1 6.9 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.4 T082748_3 - 1e-22 79.7 3.7 8.5e-06 25.9 0.5 5.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 T082748_3 - 1e-19 69.9 3.2 2.6e-05 24.3 0.4 5.7 5 0 0 5 5 5 4 Ankyrin repeat DHC_N1 PF08385.10 T141886_1 - 1.3e-20 73.5 0.0 1.7e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 FBA PF04300.11 T141886_1 - 3.2e-07 30.3 0.1 6.3e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 F-box associated region 7tm_1 PF00001.19 T063643_1 - 1.3e-40 139.2 8.0 2.1e-40 138.6 8.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 T063643_1 - 0.015 14.6 0.1 0.025 13.8 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv zf-C2H2 PF00096.24 T288171_3 - 1.8e-15 56.3 21.5 0.00023 21.3 0.1 5.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T288171_3 - 7.7e-12 45.0 17.9 2e-06 27.8 1.2 5.2 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 T288171_3 - 8.2e-12 44.8 17.4 0.0017 18.9 1.5 5.7 4 0 0 4 4 4 3 C2H2-type zinc finger SET PF00856.26 T288171_3 - 2.4e-05 24.6 0.0 8.4e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 SET domain zf-C2HC_2 PF13913.4 T288171_3 - 0.2 11.5 7.2 5.3 6.9 0.0 4.0 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2HE PF16278.3 T288171_3 - 3.6 8.0 8.6 39 4.7 1.8 3.7 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Tmemb_9 PF05434.9 T300702_1 - 0.0092 15.7 0.2 0.057 13.1 0.2 2.4 1 0 0 1 1 1 1 TMEM9 TMEM154 PF15102.4 T300702_1 - 0.024 14.4 0.1 0.024 14.4 0.1 6.0 2 1 1 5 5 5 0 TMEM154 protein family ABC2_membrane_2 PF12679.5 T300702_1 - 0.041 13.0 0.8 0.066 12.3 0.8 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Tad PF13400.4 T300702_1 - 8.9 6.6 5.8 18 5.6 5.8 1.4 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like WD40 PF00400.30 T255029_2 - 2e-46 154.9 24.9 2.6e-09 37.4 0.2 9.1 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T255029_2 - 1.8e-24 85.7 1.6 4.1e-07 30.1 0.1 5.8 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.9 T255029_2 - 1.1e-08 34.6 0.1 2.9e-08 33.3 0.1 1.8 1 0 0 1 1 1 1 LisH FAM72 PF14976.4 T029027_2 - 4.5e-54 182.4 2.6 6.6e-54 181.9 2.6 1.2 1 0 0 1 1 1 1 FAM72 protein CARD PF00619.19 T134280_1 - 4.6e-17 61.7 0.0 6.5e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 Caspase recruitment domain Trypan_PARP PF05887.9 T134280_1 - 3.9 7.4 50.2 0.015 15.2 40.5 2.0 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) HSF_DNA-bind PF00447.15 T134280_2 - 5.1e-23 81.3 0.2 8.6e-23 80.6 0.2 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding F-box-like PF12937.5 T134280_2 - 9.5e-10 38.1 0.1 2.9e-09 36.5 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T134280_2 - 9.9e-07 28.4 0.0 3.9e-06 26.4 0.0 2.0 1 0 0 1 1 1 1 F-box domain DLH PF01738.16 T278881_1 - 2e-36 125.5 0.0 2.6e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.14 T278881_1 - 0.0016 18.1 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DUF915 PF06028.9 T278881_1 - 0.0074 15.5 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) BAAT_C PF08840.9 T278881_1 - 0.016 15.0 0.2 0.21 11.4 0.1 1.9 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.11 T278881_1 - 0.021 14.3 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Fascin PF06268.11 T156512_2 - 6.6e-53 177.5 0.1 7.6e-29 100.0 0.1 2.2 2 0 0 2 2 2 2 Fascin domain FRG1 PF06229.10 T156512_2 - 5.3e-07 29.4 0.1 0.0004 20.0 0.0 3.0 2 1 1 3 3 3 1 FRG1-like domain FGF PF00167.16 T156512_2 - 0.00081 19.4 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor SAYSvFN PF10260.7 T303022_3 - 4.6e-28 96.8 2.1 7.7e-28 96.1 0.0 2.6 2 0 0 2 2 2 1 Uncharacterized conserved domain (SAYSvFN) F-box-like PF12937.5 T274726_1 - 6.1e-07 29.1 3.1 2.3e-06 27.2 0.5 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 T274726_1 - 0.02 14.6 1.6 0.021 14.6 0.1 1.8 2 0 0 2 2 2 0 F-box domain Sec7 PF01369.18 T274726_2 - 6.2e-32 110.7 0.1 9.4e-32 110.1 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain Methyltransf_23 PF13489.4 T278842_2 - 0.0086 15.9 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Glyco_transf_54 PF04666.11 T083388_2 - 3.1e-92 308.4 3.0 4.6e-92 307.8 3.0 1.2 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region RYDR_ITPR PF01365.19 T113991_1 - 1.4e-137 455.6 8.4 1.6e-73 246.4 0.0 3.1 3 0 0 3 3 3 2 RIH domain RyR PF02026.14 T113991_1 - 2e-123 402.8 2.0 3.1e-33 113.7 0.0 4.8 4 0 0 4 4 4 4 RyR domain SPRY PF00622.26 T113991_1 - 6.5e-65 216.5 0.6 5.3e-20 71.6 0.0 3.6 3 0 0 3 3 3 3 SPRY domain MIR PF02815.17 T113991_1 - 4.3e-60 202.6 0.1 4.9e-55 186.1 0.0 2.4 2 0 0 2 2 2 2 MIR domain Ins145_P3_rec PF08709.9 T113991_1 - 6.1e-59 198.7 0.0 2e-56 190.4 0.0 3.3 2 1 1 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RR_TM4-6 PF06459.10 T113991_3 - 5.8e-56 190.2 12.6 3.6e-31 108.9 7.5 3.9 3 1 1 4 4 4 2 Ryanodine Receptor TM 4-6 RIH_assoc PF08454.9 T113991_3 - 5.7e-30 103.0 0.2 5.7e-30 103.0 0.2 2.0 2 0 0 2 2 2 1 RyR and IP3R Homology associated Ion_trans PF00520.29 T113991_3 - 1.1e-13 50.9 3.0 1.1e-13 50.9 3.0 2.0 3 0 0 3 3 3 1 Ion transport protein EF-hand_1 PF00036.30 T113991_3 - 0.00015 20.9 0.1 0.00031 19.9 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 T113991_3 - 0.002 17.7 0.4 0.0048 16.5 0.4 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T113991_3 - 0.002 17.8 0.0 0.0059 16.3 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.4 T113991_3 - 0.083 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.4 T113991_3 - 0.2 12.0 5.9 0.022 15.1 1.1 1.9 2 0 0 2 2 2 0 EF-hand domain pair zf-RING_UBOX PF13445.4 T006022_3 - 5.3e-10 39.0 3.3 1.4e-09 37.6 3.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 T006022_3 - 1.6e-07 30.9 3.0 1.6e-07 30.9 3.0 3.1 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T006022_3 - 3.3e-07 29.9 4.4 3.3e-07 29.9 4.4 2.8 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T006022_3 - 9.4e-07 28.6 4.9 9.4e-07 28.6 4.9 3.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 T006022_3 - 3.8e-06 26.9 5.4 3.8e-06 26.9 5.4 3.4 3 0 0 3 3 1 1 Ring finger domain zf-B_box PF00643.22 T006022_3 - 6.6e-06 26.1 7.0 6.6e-06 26.1 7.0 3.4 4 0 0 4 4 3 1 B-box zinc finger zf-C3HC4_3 PF13920.4 T006022_3 - 8.3e-06 25.4 6.7 8.3e-06 25.4 6.7 3.7 3 1 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T006022_3 - 3e-05 23.9 6.1 3e-05 23.9 6.1 3.1 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.4 T006022_3 - 0.00045 19.9 0.2 0.00045 19.9 0.2 2.0 2 0 0 2 2 1 1 zf-RING of BARD1-type protein ATP-synt_E_2 PF08112.9 T006022_3 - 0.026 14.6 1.2 0.064 13.4 1.2 1.6 1 0 0 1 1 1 0 ATP synthase epsilon subunit Fzo_mitofusin PF04799.11 T006022_3 - 0.046 13.1 5.0 0.074 12.4 5.0 1.3 1 0 0 1 1 1 0 fzo-like conserved region DUF1664 PF07889.10 T006022_3 - 0.046 13.6 3.1 0.1 12.5 3.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) YceG_bac PF14266.4 T006022_3 - 0.05 12.4 1.0 0.073 11.8 1.0 1.1 1 0 0 1 1 1 0 Putative component of 'biosynthetic module' DUF745 PF05335.11 T006022_3 - 0.24 11.0 4.2 4.9 6.7 4.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Phasin PF05597.9 T006022_3 - 0.38 10.7 4.0 0.74 9.7 4.0 1.4 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) MukF_M PF17192.2 T006022_3 - 2.5 7.7 6.2 7.8 6.1 6.2 1.7 1 1 0 1 1 1 0 MukF middle domain EF-hand_7 PF13499.4 T370440_1 - 4.3e-22 78.2 5.1 3.9e-21 75.1 1.3 3.1 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.4 T370440_1 - 6.9e-05 22.1 0.0 0.00065 19.0 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.30 T370440_1 - 0.011 15.1 1.5 0.36 10.3 0.1 3.8 5 0 0 5 5 5 0 EF hand EF-hand_8 PF13833.4 T370440_1 - 0.015 14.9 1.2 0.61 9.8 0.0 3.9 6 0 0 6 6 6 0 EF-hand domain pair EF-hand_6 PF13405.4 T370440_1 - 0.019 14.8 2.6 0.1 12.4 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain SNARE_assoc PF09335.9 T256270_2 - 2.9e-17 63.1 3.9 6.1e-17 62.1 3.9 1.5 1 0 0 1 1 1 1 SNARE associated Golgi protein Lipase PF00151.17 T256270_3 - 1.3e-79 267.9 0.0 1.8e-79 267.4 0.0 1.1 1 0 0 1 1 1 1 Lipase SET PF00856.26 T191767_3 - 5.5e-12 46.3 0.0 1.4e-11 44.9 0.0 1.7 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.16 T191767_3 - 0.0036 17.2 9.2 0.0036 17.2 9.2 2.6 3 1 0 3 3 3 1 MYND finger zf-HIT PF04438.14 T191767_3 - 1.6 8.5 9.9 0.14 11.9 3.6 2.4 2 0 0 2 2 2 0 HIT zinc finger Pkinase PF00069.23 T165884_2 - 1.9e-20 73.2 0.0 3.9e-20 72.2 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 T165884_2 - 3.3e-11 42.8 0.0 4.6e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CK1gamma_C PF12605.6 T165884_2 - 9e-07 29.9 0.9 9e-07 29.9 0.9 3.7 2 1 1 3 3 3 2 Casein kinase 1 gamma C terminal F-box-like PF12937.5 T134521_2 - 2.3e-07 30.4 0.1 8.1e-07 28.7 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T134521_2 - 1.3e-05 24.8 0.3 0.00012 21.7 0.0 2.6 2 1 0 2 2 2 1 F-box domain LRR_4 PF12799.5 T134521_2 - 5.7e-05 23.3 4.7 0.23 11.8 0.0 3.9 3 1 2 5 5 5 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 T134521_2 - 0.011 15.6 5.7 4 7.6 0.0 5.4 6 0 0 6 6 6 0 Leucine Rich repeat LRR_8 PF13855.4 T134521_2 - 0.53 10.0 1.9 3.7 7.3 0.1 2.8 1 1 2 3 3 3 0 Leucine rich repeat LRR_1 PF00560.31 T134521_2 - 0.79 10.3 7.9 12 6.7 0.2 5.3 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_4 PF12799.5 T134521_3 - 3.2e-05 24.0 8.7 0.12 12.6 0.1 6.0 2 2 7 9 9 9 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 T134521_3 - 0.0049 16.7 14.5 2.2 8.4 0.1 7.0 9 0 0 9 9 9 2 Leucine Rich repeat LRR_8 PF13855.4 T134521_3 - 0.21 11.2 8.1 6.2 6.5 0.2 4.9 3 2 1 5 5 5 0 Leucine rich repeat BTB PF00651.29 T281716_2 - 1.3e-23 83.2 0.5 2.2e-23 82.4 0.5 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 T281716_2 - 1.1e-12 47.6 38.2 5.4e-07 29.6 6.2 6.3 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 T281716_2 - 2.1e-07 31.1 40.6 0.065 14.0 0.3 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger zf-met PF12874.5 T281716_2 - 4.8e-06 26.6 6.4 0.00031 20.9 0.6 6.0 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T281716_2 - 0.00087 19.4 0.9 0.00087 19.4 0.9 6.2 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.24 T281716_2 - 0.011 16.1 44.3 0.044 14.1 0.2 6.1 6 0 0 6 6 6 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 T281716_2 - 1.7 8.5 34.6 0.85 9.5 0.1 6.4 6 0 0 6 6 6 0 C2H2-type zinc finger MYCBPAP PF14646.4 T150442_1 - 5.8e-84 282.4 0.7 7.7e-64 216.1 0.0 2.1 2 0 0 2 2 2 2 MYCBP-associated protein family MYCBPAP PF14646.4 T150442_2 - 3.7e-36 124.9 0.8 2e-19 69.7 0.0 2.1 2 0 0 2 2 2 2 MYCBP-associated protein family ENTH PF01417.18 T150442_3 - 2.2e-49 166.5 0.0 3.3e-49 166.0 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.14 T150442_3 - 0.00024 20.1 0.0 0.00035 19.5 0.0 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.17 T150442_3 - 0.054 13.2 0.0 0.089 12.5 0.0 1.3 1 0 0 1 1 1 0 VHS domain UIM PF02809.18 T150442_3 - 0.15 11.9 7.3 0.3 11.0 7.3 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif CC2-LZ PF16516.3 T037309_1 - 2.3e-30 104.8 16.0 2.3e-30 104.8 16.0 4.3 2 2 2 4 4 4 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator NEMO PF11577.6 T037309_1 - 4.3e-27 93.8 14.8 4.3e-27 93.8 14.8 3.7 5 0 0 5 5 5 1 NF-kappa-B essential modulator NEMO LisH PF08513.9 T037309_1 - 0.027 14.3 0.0 5.8 6.9 0.0 2.5 2 0 0 2 2 2 0 LisH Mcm10 PF09332.9 T037309_3 - 1.6e-148 494.7 12.2 1.6e-148 494.7 12.2 2.0 2 0 0 2 2 2 1 Mcm10 replication factor zf-primase PF09329.9 T037309_3 - 5.1e-19 67.7 1.7 1.4e-18 66.3 1.7 1.8 1 0 0 1 1 1 1 Primase zinc finger RRM_1 PF00076.20 T167429_2 - 4.1e-59 196.2 0.1 1.5e-18 66.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 T167429_2 - 6.5e-09 35.3 0.0 0.0076 15.7 0.0 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 T167429_2 - 0.08 12.9 0.0 1.5 8.8 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif Pkinase PF00069.23 T154703_2 - 4.1e-78 262.3 0.0 5.1e-78 261.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ten1_2 PF15490.4 T154703_2 - 2.6e-43 146.4 0.0 3.7e-43 145.8 0.0 1.2 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Pkinase_Tyr PF07714.15 T154703_2 - 7.7e-36 123.6 0.0 1.2e-35 122.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T154703_2 - 0.06 12.5 0.1 0.79 8.8 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Amidase PF01425.19 T010262_3 - 1.2e-117 393.6 0.0 1.5e-117 393.2 0.0 1.1 1 0 0 1 1 1 1 Amidase Methyltr_RsmB-F PF01189.15 T010262_3 - 7.5e-26 90.9 0.0 1.1e-25 90.3 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.17 T010262_3 - 0.01 15.8 0.0 0.039 13.9 0.0 1.8 2 0 0 2 2 2 0 FtsJ-like methyltransferase Sec7 PF01369.18 T197087_3 - 1.5e-34 119.2 0.0 2.1e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.4 T197087_3 - 1.8e-32 112.1 0.0 2.8e-32 111.4 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 T197087_3 - 1.2e-08 35.2 0.0 2e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 PH domain Myosin_tail_1 PF01576.17 T141481_2 - 0 1701.8 316.3 0 1701.5 316.3 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 T141481_2 - 0 1021.1 0.9 0 1021.1 0.9 2.4 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_N PF02736.17 T141481_2 - 2.5e-12 46.3 0.1 5.6e-12 45.1 0.1 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ADIP PF11559.6 T141481_2 - 0.00018 21.5 20.8 0.00018 21.5 20.8 14.4 1 1 12 14 14 14 4 Afadin- and alpha -actinin-Binding IQ PF00612.25 T141481_2 - 0.00019 20.8 0.2 0.00065 19.1 0.2 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_22 PF13401.4 T141481_2 - 0.17 12.0 0.0 0.17 12.0 0.0 4.9 4 0 0 4 4 4 0 AAA domain Pur_DNA_glyco PF02245.14 T124000_2 - 2.3e-40 137.7 0.0 3.3e-40 137.2 0.0 1.2 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) Spectrin PF00435.19 T115144_1 - 2.4e-18 66.4 19.4 2.9e-10 40.4 8.5 2.2 2 0 0 2 2 2 2 Spectrin repeat PH PF00169.27 T115144_1 - 6.4e-05 23.3 0.0 0.00013 22.3 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 T115144_1 - 0.0026 18.0 0.0 0.005 17.1 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Spectrin PF00435.19 T115144_3 - 2.2e-303 982.6 329.6 1e-18 67.6 4.5 30.0 30 0 0 30 30 30 29 Spectrin repeat IRF PF00605.15 T115144_3 - 0.48 10.6 4.3 1.3 9.2 0.0 3.5 3 0 0 3 3 3 0 Interferon regulatory factor transcription factor zf-ZPR1 PF03367.11 T115144_3 - 3.8 7.2 10.9 0.053 13.2 0.7 3.3 3 0 0 3 3 3 0 ZPR1 zinc-finger domain Angiomotin_C PF12240.6 T065996_2 - 7.1e-96 319.6 15.9 7.1e-96 319.6 15.9 3.3 2 1 0 2 2 2 2 Angiomotin C terminal PNP_UDP_1 PF01048.18 T356482_2 - 2e-46 158.0 0.0 2.5e-46 157.7 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily TRP_2 PF08344.9 T251640_2 - 1.2e-24 86.1 2.2 2.3e-24 85.3 2.2 1.5 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.5 T251640_2 - 1.4e-05 25.5 1.6 0.0004 20.8 0.4 2.6 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T251640_2 - 0.00011 22.6 0.1 0.32 11.5 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) EVC2_like PF12297.6 T251640_3 - 0.15 10.5 2.4 0.23 10.0 2.4 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein V-set PF07686.15 T017418_1 - 0.055 13.5 0.0 0.085 12.9 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin V-set domain WD40 PF00400.30 T207605_2 - 2.3e-27 94.5 12.3 0.00019 22.0 0.1 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T207605_2 - 2.1e-15 56.6 0.1 0.0024 18.0 0.0 5.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 T207605_2 - 0.00014 21.7 0.0 0.046 13.5 0.0 2.7 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.4 T207605_2 - 0.0015 18.0 0.6 0.0099 15.3 0.6 2.1 1 1 0 1 1 1 1 PQQ-like domain Ge1_WD40 PF16529.3 T207605_2 - 0.0056 15.6 0.1 0.11 11.3 0.0 2.7 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.3 T207605_2 - 0.0098 15.1 0.0 0.89 8.7 0.0 3.0 3 0 0 3 3 3 1 WD40-like domain Nup160 PF11715.6 T207605_2 - 0.015 13.8 0.1 0.83 8.1 0.1 3.0 3 0 0 3 3 3 0 Nucleoporin Nup120/160 DUF5046 PF16465.3 T207605_2 - 0.049 13.0 0.0 1.4 8.2 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5046) RAB3GAP2_N PF14655.4 T207605_2 - 0.26 10.3 0.1 0.81 8.7 0.0 1.8 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus tRNA_anti-codon PF01336.23 T204900_3 - 0.0035 17.2 0.1 0.006 16.4 0.1 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain ORMDL PF04061.12 T146963_2 - 6e-52 174.9 4.7 9.2e-52 174.3 4.7 1.3 1 0 0 1 1 1 1 ORMDL family Gasdermin PF04598.10 T146963_2 - 5.6e-13 48.6 2.2 8.5e-13 48.0 2.2 1.1 1 0 0 1 1 1 1 Gasdermin family Gasdermin PF04598.10 T146963_3 - 1.5e-26 93.4 0.0 2e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Gasdermin family Adipogenin PF15202.4 T034282_1 - 0.11 12.4 2.4 0.27 11.1 2.4 1.6 1 0 0 1 1 1 0 Adipogenin GOLGA2L5 PF15070.4 T120860_3 - 7e-17 61.2 17.8 7e-17 61.2 17.8 2.1 1 1 1 2 2 2 1 Putative golgin subfamily A member 2-like protein 5 WW PF00397.24 T058363_2 - 3.7e-19 68.2 20.3 1.8e-09 37.3 3.8 2.7 2 0 0 2 2 2 2 WW domain Peptidase_M14 PF00246.22 T058363_3 - 1.2e-17 64.6 0.0 1.8e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.12 T058363_3 - 0.21 10.5 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family zf-H2C2_2 PF13465.4 T179976_1 - 3.9e-86 279.8 160.5 2.1e-07 30.9 0.8 25.8 26 0 0 26 26 26 19 Zinc-finger double domain zf-C2H2 PF00096.24 T179976_1 - 6.5e-52 171.1 172.5 1.2e-05 25.3 1.5 25.1 24 0 0 24 24 24 18 Zinc finger, C2H2 type KRAB PF01352.25 T179976_1 - 3.8e-24 83.9 0.9 1.1e-23 82.5 0.9 1.8 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T179976_1 - 3.6e-18 64.5 164.0 0.068 13.9 0.7 23.9 24 0 0 24 24 24 16 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T179976_2 - 3.5e-52 172.5 48.3 5.5e-09 35.9 0.4 9.8 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 T179976_2 - 1.2e-34 116.7 71.7 8.6e-06 25.8 1.9 10.3 10 0 0 10 10 10 8 Zinc finger, C2H2 type KRAB PF01352.25 T179976_2 - 1.6e-20 72.3 0.4 4.2e-20 71.0 0.4 1.8 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T179976_2 - 3.9e-14 52.0 73.3 0.016 15.8 1.1 10.3 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T179976_2 - 6.3e-07 29.1 50.1 0.078 12.8 0.8 8.7 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T179976_2 - 0.00071 19.7 29.4 0.77 10.0 0.9 7.0 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T179976_2 - 0.53 10.3 38.7 1.2 9.2 3.7 5.6 3 2 1 5 5 5 0 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T179976_2 - 1.3 9.6 25.8 9.8 6.9 1.9 4.7 3 1 1 4 4 4 0 zinc-ribbon family YadA_stalk PF05662.12 T179976_2 - 4.5 6.9 5.1 43 3.8 0.1 4.0 4 0 0 4 4 4 0 Coiled stalk of trimeric autotransporter adhesin zf-H2C2_2 PF13465.4 T179976_3 - 2.2e-07 30.9 5.7 5.7e-05 23.3 1.1 5.8 6 0 0 6 6 6 3 Zinc-finger double domain DSPc PF00782.18 T341648_3 - 1.1e-29 102.8 0.0 1.6e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 T341648_3 - 0.0061 16.0 0.0 0.0096 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.10 T341648_3 - 0.11 12.7 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain BRICHOS PF04089.12 T125375_1 - 1.1e-16 60.5 0.0 1.7e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain Hydrolase_6 PF13344.4 T125375_2 - 9.9e-27 92.9 0.0 1.6e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 T125375_2 - 5.2e-17 61.6 0.0 9e-17 60.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.24 T125375_2 - 4.5e-13 49.8 0.0 2.1e-12 47.6 0.0 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 T125375_2 - 2.4e-05 24.4 0.0 0.015 15.3 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.8 T125375_2 - 0.14 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Pept_tRNA_hydro PF01195.17 T366842_3 - 8.6e-37 126.5 0.0 1.3e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase V-ATPase_C PF03223.13 T184526_1 - 4.1e-103 345.5 7.2 1.1e-63 215.8 5.3 2.1 2 0 0 2 2 2 2 V-ATPase subunit C zf-H2C2_2 PF13465.4 T241273_1 - 1e-106 344.9 79.6 9e-09 35.3 0.1 14.9 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 T241273_1 - 4.4e-78 253.5 94.4 3.7e-07 30.1 0.2 13.7 13 0 0 13 13 13 13 Zinc finger, C2H2 type SCAN PF02023.15 T241273_1 - 5.5e-40 135.0 2.2 9.8e-40 134.2 2.2 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2_4 PF13894.4 T241273_1 - 1.7e-39 130.9 90.6 0.0031 18.1 0.4 14.0 13 0 0 13 13 13 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T241273_1 - 1.2e-24 85.5 73.6 0.0003 20.5 0.5 13.6 13 0 0 13 13 13 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T241273_1 - 9.9e-12 44.7 72.7 0.005 16.8 2.3 8.9 4 4 7 11 11 11 9 Zinc ribbon domain KRAB PF01352.25 T241273_1 - 1.4e-10 40.5 0.2 2.8e-10 39.6 0.2 1.5 1 0 0 1 1 1 1 KRAB box XPA_N PF01286.16 T241273_1 - 4.5e-08 32.9 63.4 2.5 8.1 0.3 13.5 13 0 0 13 13 13 6 XPA protein N-terminal zinc_ribbon_15 PF17032.3 T241273_1 - 1.1e-05 26.0 55.2 0.4 11.3 1.6 7.3 1 1 10 12 12 12 9 zinc-ribbon family DZR PF12773.5 T241273_1 - 0.00022 21.1 57.5 0.31 11.0 1.0 6.9 2 1 1 3 3 2 2 Double zinc ribbon zf-C2H2_jaz PF12171.6 T241273_1 - 0.0007 19.7 62.7 1.1 9.5 0.1 13.2 14 0 0 14 14 13 5 Zinc-finger double-stranded RNA-binding C1_4 PF07975.10 T241273_1 - 0.21 11.8 61.3 1.2 9.3 1.8 9.7 2 2 10 12 12 12 0 TFIIH C1-like domain OSCP PF00213.16 T225394_1 - 1.9e-44 151.7 0.8 2.4e-44 151.4 0.8 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit HLH PF00010.24 T162516_1 - 2.6e-11 43.2 1.0 6e-11 42.0 1.0 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 T162516_1 - 4.8 5.2 6.7 7.2 4.6 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein wnt PF00110.17 T077978_2 - 3.6e-120 401.0 11.1 4.3e-120 400.7 11.1 1.1 1 0 0 1 1 1 1 wnt family Trypsin PF00089.24 T179543_1 - 8.9e-56 189.0 0.1 1.3e-55 188.5 0.1 1.2 1 0 0 1 1 1 1 Trypsin DUF1725 PF08333.9 T179543_1 - 3.5e-07 29.5 1.0 6.4e-07 28.7 1.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1986 PF09342.9 T179543_1 - 0.033 14.4 0.0 0.058 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Trypsin PF00089.24 T179543_2 - 2.7e-235 776.0 21.5 8.4e-68 228.3 0.7 5.2 5 0 0 5 5 5 5 Trypsin DUF1986 PF09342.9 T179543_2 - 1.8e-06 28.2 0.0 0.15 12.3 0.0 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF1986) RRM_1 PF00076.20 T106573_3 - 2.1e-29 101.0 0.1 1e-15 57.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 T106573_3 - 6.2e-05 22.9 0.1 0.036 14.0 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.4 T106573_3 - 0.00022 21.0 0.0 0.00096 18.9 0.0 1.9 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF4551 PF15087.4 T106573_3 - 2.2 6.9 13.9 4 6.0 13.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Death PF00531.20 T303275_1 - 2.9e-14 52.9 0.5 2.2e-13 50.0 0.1 2.1 2 0 0 2 2 2 1 Death domain ZU5 PF00791.18 T303275_3 - 9.5e-25 86.7 0.0 1.7e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 ZU5 domain UPA PF17217.1 T303275_3 - 1.4e-08 34.8 0.0 2.3e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 UPA domain WD40 PF00400.30 T168963_1 - 8e-15 54.9 3.7 0.0024 18.5 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T168963_1 - 0.0033 17.6 0.0 0.17 12.1 0.0 3.0 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 T168963_1 - 0.073 12.2 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain WD40 PF00400.30 T168963_2 - 6.3e-13 48.9 1.9 6.8e-05 23.4 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat RNF111_N PF15303.4 T117400_1 - 1.7e-128 428.1 24.0 1.7e-128 428.1 24.0 2.3 2 0 0 2 2 1 1 E3 ubiquitin-protein ligase Arkadia N-terminus zf-RING_2 PF13639.4 T117400_1 - 6.9e-13 48.5 6.7 6.9e-13 48.5 6.7 2.8 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 T117400_1 - 2.5e-09 36.7 6.6 8.9e-09 34.9 6.6 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 T117400_1 - 2.7e-07 30.0 2.6 2.7e-07 30.0 2.6 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.5 T117400_1 - 7.1e-07 29.3 4.1 7.1e-07 29.3 4.1 2.5 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 T117400_1 - 3.6e-06 26.6 5.9 3.6e-06 26.6 5.9 2.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T117400_1 - 5.2e-06 26.1 4.5 5.2e-06 26.1 4.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T117400_1 - 3.2e-05 23.7 4.6 9.3e-05 22.2 3.8 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.4 T117400_1 - 0.00013 21.6 4.6 0.00051 19.7 4.6 2.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 T117400_1 - 0.061 13.2 4.1 0.19 11.7 3.4 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.5 T117400_1 - 0.89 9.6 6.3 3.9 7.5 6.3 2.2 1 0 0 1 1 1 0 RING-variant domain HSP70 PF00012.18 T092502_1 - 9.4e-172 572.2 2.4 9.4e-172 572.2 2.4 2.8 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.11 T092502_1 - 1.7e-05 23.7 0.0 3e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Calponin PF00402.16 T165458_2 - 2e-34 116.7 22.4 1.3e-15 56.6 0.8 4.0 3 0 0 3 3 3 3 Calponin family repeat CH PF00307.29 T165458_2 - 5.5e-19 68.2 0.0 8.7e-19 67.6 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 T165458_2 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 CAMSAP CH domain ABC2_membrane_3 PF12698.5 T165458_3 - 1.6e-60 204.9 22.4 8.1e-44 150.0 5.5 3.0 3 0 0 3 3 3 2 ABC-2 family transporter protein RhoGAP PF00620.25 T165458_3 - 3.7e-50 169.5 0.0 6.9e-50 168.7 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain ABC_tran PF00005.25 T165458_3 - 4.3e-45 153.5 0.0 1.7e-24 86.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 T165458_3 - 1.3e-20 74.3 0.4 1.2e-06 28.5 0.0 4.1 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system C1_1 PF00130.20 T165458_3 - 5.2e-05 22.9 12.7 0.00013 21.7 12.7 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FCH PF00611.21 T165458_3 - 0.0001 22.3 0.8 0.00024 21.2 0.8 1.6 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain AAA_15 PF13175.4 T165458_3 - 0.0072 15.8 0.0 2 7.8 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain AAA_23 PF13476.4 T165458_3 - 0.031 14.6 0.1 0.031 14.6 0.1 3.5 3 1 0 3 3 2 0 AAA domain DUF4162 PF13732.4 T165458_3 - 0.038 14.6 0.0 5.3 7.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) SRP54 PF00448.20 T165458_3 - 0.091 12.2 0.3 1.6 8.2 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_29 PF13555.4 T165458_3 - 0.19 11.3 1.5 0.52 9.9 0.3 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain KRAB PF01352.25 T176823_2 - 1.5e-23 82.1 0.1 2.3e-23 81.4 0.1 1.3 1 0 0 1 1 1 1 KRAB box KRAB PF01352.25 T176823_3 - 7.2e-20 70.3 1.0 7.2e-20 70.3 1.0 1.9 2 0 0 2 2 2 1 KRAB box SPATA3 PF15662.3 T209470_1 - 1.5e-31 110.4 20.7 1.5e-31 110.4 20.7 2.4 2 0 0 2 2 2 1 Spermatogenesis-associated protein 3 family Pex14_N PF04695.11 T209470_1 - 1.7 9.2 7.7 4.4 7.9 7.7 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SPATA3 PF15662.3 T209470_3 - 2.5e-09 37.9 6.4 6.2e-09 36.6 6.4 1.7 1 0 0 1 1 1 1 Spermatogenesis-associated protein 3 family NPIP PF06409.9 T127835_1 - 1.1e-48 165.6 19.4 2e-37 128.7 1.7 3.1 1 1 2 3 3 3 3 Nuclear pore complex interacting protein (NPIP) Hep_core_N PF08290.9 T127835_2 - 6.2 6.8 7.9 51 3.9 0.0 3.9 4 0 0 4 4 4 0 Hepatitis core protein, putative zinc finger NPIP PF06409.9 T127835_3 - 0.16 11.0 0.3 0.23 10.5 0.3 1.1 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) Bac_surface_Ag PF01103.21 T234937_2 - 2e-62 211.4 0.9 2.6e-62 211.1 0.9 1.1 1 0 0 1 1 1 1 Surface antigen CH PF00307.29 T234937_3 - 3.9e-57 191.0 15.1 5.8e-16 58.5 0.7 4.4 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.6 T234937_3 - 1e-06 28.3 1.6 0.07 12.8 0.1 4.3 4 0 0 4 4 4 3 CAMSAP CH domain CH_2 PF06294.9 T234937_3 - 0.1 12.6 0.2 6 6.9 0.0 3.5 4 0 0 4 4 4 0 CH-like domain in sperm protein HERV-K_env_2 PF13804.4 T141275_2 - 5.1e-46 156.4 3.0 8.3e-46 155.7 3.0 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein IN_DBD_C PF00552.19 T141275_2 - 1.9e-07 30.1 1.5 1.9e-07 30.1 1.5 2.6 2 0 0 2 2 2 1 Integrase DNA binding domain HERV-K_REC PF15695.3 T141275_3 - 9e-10 38.4 3.3 1.8e-09 37.4 3.3 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Lipoxygenase PF00305.17 T141275_3 - 3.2e-06 25.7 0.1 0.0029 16.0 0.0 2.0 2 0 0 2 2 2 2 Lipoxygenase DCX PF03607.15 T338792_2 - 8.2e-28 96.2 0.0 9.2e-16 57.6 0.0 2.4 2 0 0 2 2 2 2 Doublecortin AAA_21 PF13304.4 T153238_1 - 0.054 13.2 0.0 0.084 12.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.5 T153238_2 - 7.6e-32 110.6 56.5 5.4e-25 88.1 22.2 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.25 T153238_2 - 3.6e-20 72.8 0.1 5.6e-20 72.1 0.1 1.2 1 0 0 1 1 1 1 ABC transporter ABC_tran PF00005.25 T153238_3 - 6e-92 305.2 0.4 6.8e-32 110.7 0.1 3.3 3 0 0 3 3 3 3 ABC transporter ABC2_membrane_3 PF12698.5 T153238_3 - 8.4e-37 126.9 73.4 3.9e-29 101.7 30.7 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.4 T153238_3 - 7e-24 85.0 7.2 2e-06 27.7 0.1 6.4 5 1 1 6 6 6 5 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 T153238_3 - 2.9e-14 53.2 0.4 0.00055 19.7 0.0 3.3 3 0 0 3 3 3 3 Protein of unknown function, DUF258 AAA_29 PF13555.4 T153238_3 - 5.6e-11 41.9 3.6 0.014 15.0 0.0 3.4 3 0 0 3 3 3 3 P-loop containing region of AAA domain AAA_23 PF13476.4 T153238_3 - 6.5e-08 33.2 16.0 0.0063 16.9 0.1 4.0 4 0 0 4 4 3 3 AAA domain MMR_HSR1 PF01926.21 T153238_3 - 1e-07 31.9 1.1 0.42 10.6 0.1 3.4 3 0 0 3 3 3 3 50S ribosome-binding GTPase SMC_N PF02463.17 T153238_3 - 3.8e-06 26.3 5.3 0.015 14.6 0.3 4.6 3 2 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 T153238_3 - 1.1e-05 25.8 0.0 0.83 9.9 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain DUF4162 PF13732.4 T153238_3 - 4.6e-05 23.9 1.0 7.6 7.2 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4162) Dynamin_N PF00350.21 T153238_3 - 0.00043 20.3 0.1 1.1 9.2 0.0 3.3 3 0 0 3 3 3 1 Dynamin family AAA_24 PF13479.4 T153238_3 - 0.0019 17.8 0.1 2.2 7.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.4 T153238_3 - 0.0044 16.6 0.2 15 5.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.23 T153238_3 - 0.0061 16.1 0.0 2.1 7.8 0.0 2.7 3 0 0 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_22 PF13401.4 T153238_3 - 0.012 15.8 2.4 7.1 6.8 0.2 3.3 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.15 T153238_3 - 0.018 14.7 0.2 4.8 6.8 0.0 3.6 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_25 PF13481.4 T153238_3 - 0.026 14.0 0.1 20 4.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain cobW PF02492.17 T153238_3 - 0.03 13.8 2.9 11 5.4 0.0 3.5 4 0 0 4 4 3 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.20 T153238_3 - 0.03 14.6 3.0 23 5.3 0.0 4.0 4 0 0 4 4 4 0 RNA helicase Roc PF08477.11 T153238_3 - 0.06 13.4 0.1 34 4.6 0.0 3.3 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.4 T153238_3 - 0.13 11.7 12.3 0.28 10.6 2.0 3.7 3 1 0 3 3 3 0 AAA ATPase domain AAA_18 PF13238.4 T153238_3 - 0.18 12.2 0.1 1e+02 3.3 0.0 3.3 3 0 0 3 3 3 0 AAA domain GPS2_interact PF15784.3 T142466_3 - 5.6e-35 119.7 6.8 5.6e-35 119.7 6.8 4.3 3 0 0 3 3 3 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 T142466_3 - 1.1e-17 63.8 0.2 5.8e-12 45.4 0.2 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T142466_3 - 0.0071 16.4 2.0 0.091 12.9 0.3 2.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Neur_chan_memb PF02932.14 T371662_3 - 1e-12 48.5 2.3 2.4e-07 30.9 0.4 2.3 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CSD PF00313.20 T126998_1 - 9.2e-11 41.3 0.0 1.6e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain DUF4339 PF14237.4 T126998_2 - 0.043 13.5 0.0 0.098 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4339) 7tm_1 PF00001.19 T013117_1 - 2.5e-23 82.6 9.4 4.2e-23 81.8 9.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TMEM154 PF15102.4 T013117_3 - 4.8 6.9 10.2 8.7 6.1 10.2 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF1943 PF09172.9 T127371_2 - 2.9e-59 200.7 0.0 4.6e-59 200.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) Vitellogenin_N PF01347.20 T127371_2 - 5.4e-53 180.2 0.0 6.7e-53 179.9 0.0 1.1 1 0 0 1 1 1 1 Lipoprotein amino terminal region VWD PF00094.23 T127371_2 - 0.00015 22.0 0.0 0.0004 20.5 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type D domain DAG1 PF05454.9 T242567_2 - 6.1e-162 537.7 7.3 8.9e-162 537.1 7.3 1.2 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) TMEM154 PF15102.4 T242567_2 - 0.0085 15.9 0.0 0.0085 15.9 0.0 1.8 2 0 0 2 2 2 1 TMEM154 protein family 7tm_1 PF00001.19 T364658_1 - 8.8e-37 126.7 21.7 1.4e-36 126.0 21.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sulfate_transp PF00916.18 T029016_1 - 1.2e-92 310.5 20.0 1.6e-92 310.0 20.0 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 T029016_1 - 8.8e-23 80.0 0.0 1.5e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.4 T029016_1 - 0.12 12.6 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 STAS domain CaM-KIIN PF15170.4 T004921_3 - 3e-45 152.1 0.0 4.9e-45 151.5 0.0 1.3 1 0 0 1 1 1 1 Calcium/calmodulin-dependent protein kinase II inhibitor Ank_2 PF12796.5 T078717_1 - 7.8e-14 51.9 0.0 4.5e-10 39.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T078717_1 - 3.3e-09 37.0 0.1 3.3e-05 24.2 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 T078717_1 - 1.9e-07 31.1 0.7 0.00055 20.1 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 T078717_1 - 2.6e-07 30.3 0.2 0.21 12.1 0.1 5.4 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.28 T078717_1 - 2.1e-05 24.7 0.4 0.044 14.1 0.1 3.7 3 0 0 3 3 3 1 Ankyrin repeat XPG_I PF00867.16 T034014_1 - 5.5e-23 81.0 0.2 1.2e-22 80.0 0.2 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.15 T034014_1 - 1.6e-21 76.5 0.0 2.9e-21 75.7 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.5 T034014_1 - 0.008 15.5 0.1 0.015 14.6 0.1 1.3 1 0 0 1 1 1 1 XPG domain containing FSA_C PF10479.7 T270675_2 - 4.7e-162 540.5 9.5 1.2e-127 426.9 3.1 2.8 1 1 1 2 2 2 2 Fragile site-associated protein C-terminus ELMO_CED12 PF04727.11 T192936_1 - 0.00015 21.8 0.0 0.00023 21.2 0.0 1.2 1 0 0 1 1 1 1 ELMO/CED-12 family ELMO_CED12 PF04727.11 T192936_3 - 4.4e-06 26.8 0.0 8e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family Anoctamin PF04547.10 T052130_3 - 8e-134 446.6 14.2 1.2e-133 446.0 14.2 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel TIR PF01582.18 T052130_3 - 6.3e-17 61.8 0.0 1.9e-16 60.2 0.0 1.8 2 0 0 2 2 2 1 TIR domain Anoct_dimer PF16178.3 T052130_3 - 5.1e-09 36.1 0.1 2.7e-05 23.9 0.0 2.4 2 0 0 2 2 2 2 Dimerisation domain of Ca+-activated chloride-channel, anoctamin TIR_2 PF13676.4 T052130_3 - 6e-09 36.0 0.0 2.2e-08 34.2 0.0 2.0 1 0 0 1 1 1 1 TIR domain Ig_2 PF13895.4 T052130_3 - 0.0028 17.8 0.0 0.008 16.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Glyco_hydro_67N PF03648.12 T052130_3 - 0.13 12.5 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus 7tm_2 PF00002.22 T133199_1 - 1.2e-22 80.3 8.4 1.2e-22 80.3 8.4 2.2 2 0 0 2 2 2 2 7 transmembrane receptor (Secretin family) GPS PF01825.19 T133199_1 - 1.6e-13 50.9 1.2 6.3e-13 49.0 1.2 2.2 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Oscp1 PF10188.7 T008057_1 - 1.8e-77 259.2 3.0 2.7e-77 258.7 3.0 1.3 1 0 0 1 1 1 1 Organic solute transport protein 1 Ribosomal_S15 PF00312.20 T008057_1 - 6.5e-20 71.0 2.2 1.3e-19 70.0 2.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S15 Lep_receptor_Ig PF06328.9 T008057_2 - 1.9e-31 107.8 0.2 4.1e-31 106.7 0.2 1.6 1 0 0 1 1 1 1 Ig-like C2-type domain fn3 PF00041.19 T008057_2 - 2.3e-18 66.2 0.4 1.5e-06 28.4 0.0 5.3 5 0 0 5 5 5 3 Fibronectin type III domain EpoR_lig-bind PF09067.8 T008057_2 - 0.0058 16.7 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3_2 PF16893.3 T008057_2 - 0.053 13.6 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Fibronectin type III domain FAM198 PF15051.4 T241076_1 - 4e-140 466.2 0.0 5.4e-140 465.8 0.0 1.1 1 0 0 1 1 1 1 FAM198 protein KRAB PF01352.25 T241076_3 - 7.5e-18 63.8 0.4 1.4e-17 63.0 0.4 1.4 1 0 0 1 1 1 1 KRAB box COG4 PF08318.10 T135506_3 - 6.1e-96 321.3 4.9 1.3e-95 320.2 4.9 1.6 1 0 0 1 1 1 1 COG4 transport protein RINT1_TIP1 PF04437.11 T135506_3 - 6.8e-07 28.4 0.6 1.5e-06 27.3 0.6 1.5 1 0 0 1 1 1 1 RINT-1 / TIP-1 family Bac_thur_toxin PF01338.16 T135506_3 - 0.06 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacillus thuringiensis toxin COG5 PF10392.7 T135506_3 - 3.6 7.6 10.7 2.4 8.2 0.3 3.8 3 2 2 5 5 5 0 Golgi transport complex subunit 5 NTP_transferase PF00483.21 T208158_1 - 2.2e-27 96.1 0.0 3.3e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase ASC PF00858.22 T208158_1 - 9.1e-25 87.3 0.0 1.8e-24 86.4 0.0 1.4 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Hexapep PF00132.22 T208158_1 - 4.6e-05 22.9 2.7 6.3e-05 22.4 0.3 2.2 2 0 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.3 T208158_1 - 0.3 9.0 0.1 0.42 8.5 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) I-set PF07679.14 T208158_2 - 1.9e-166 540.5 0.0 1.8e-21 75.8 0.0 9.8 10 0 0 10 10 10 9 Immunoglobulin I-set domain Ig_3 PF13927.4 T208158_2 - 1.1e-91 301.3 0.0 1.9e-10 41.0 0.0 9.7 9 0 0 9 9 9 9 Immunoglobulin domain ASC PF00858.22 T208158_2 - 2.2e-61 207.9 0.0 3.3e-61 207.4 0.0 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Ig_2 PF13895.4 T208158_2 - 1.2e-53 179.3 0.0 9e-07 29.0 0.0 10.1 10 0 0 10 10 10 9 Immunoglobulin domain ig PF00047.23 T208158_2 - 1.2e-48 163.1 0.0 3.8e-06 26.8 0.0 10.5 10 0 0 10 10 10 8 Immunoglobulin domain SPEG_u2 PF16650.3 T208158_2 - 1.4e-31 108.3 14.4 4.8e-31 106.6 14.4 2.0 1 0 0 1 1 1 1 Unstructured region on SPEG complex protein V-set PF07686.15 T208158_2 - 2.2e-14 53.4 0.1 0.11 12.5 0.0 8.9 8 2 0 8 8 8 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 T208158_2 - 1.1e-09 38.1 0.0 3.3 7.7 0.0 7.6 7 0 0 7 7 7 2 CD80-like C2-set immunoglobulin domain Pkinase PF00069.23 T208158_2 - 2.4e-09 36.8 0.0 3.4e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Receptor_2B4 PF11465.6 T208158_2 - 0.00029 20.9 0.0 24 5.0 0.0 4.9 4 1 1 5 5 5 0 Natural killer cell receptor 2B4 Pkinase_Tyr PF07714.15 T208158_2 - 0.0048 16.1 0.0 0.0068 15.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase fn3 PF00041.19 T208158_2 - 0.0072 16.5 0.1 0.017 15.3 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Izumo-Ig PF16706.3 T208158_2 - 0.016 15.1 0.9 3.1 7.8 0.1 4.0 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain IQ PF00612.25 T208158_2 - 0.083 12.6 8.1 0.0036 16.8 1.3 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif Pkinase PF00069.23 T208158_3 - 2.3e-90 302.4 0.0 5.3e-55 186.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 T208158_3 - 1.7e-39 135.6 0.0 1.6e-26 93.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase I-set PF07679.14 T208158_3 - 2e-13 50.1 0.0 3.1e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T208158_3 - 1.1e-10 41.8 0.0 3e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T208158_3 - 0.0002 21.5 0.0 0.00053 20.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T208158_3 - 0.007 16.4 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.19 T208158_3 - 0.017 15.4 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III domain Kinase-like PF14531.4 T208158_3 - 0.2 10.8 0.0 0.36 10.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like CaKB PF03185.13 T082070_2 - 3.9e-74 248.4 2.2 6.2e-74 247.8 2.2 1.3 1 0 0 1 1 1 1 Calcium-activated potassium channel, beta subunit WD40 PF00400.30 T189550_1 - 3.5e-53 176.3 77.5 6.3e-05 23.5 0.0 25.4 29 0 0 29 29 29 14 WD domain, G-beta repeat HELP PF03451.12 T189550_1 - 1.1e-34 117.9 0.2 1.3e-19 69.7 0.1 2.4 2 0 0 2 2 2 2 HELP motif ANAPC4_WD40 PF12894.5 T189550_1 - 7.3e-34 115.8 8.9 6e-07 29.5 0.0 11.5 8 3 3 11 11 11 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T189550_1 - 2.5e-08 33.1 3.6 0.026 13.4 0.0 6.3 4 3 3 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.9 T189550_1 - 8e-06 24.7 0.0 0.015 14.0 0.0 4.0 4 0 0 4 4 4 1 Nup133 N terminal like Frtz PF11768.6 T189550_1 - 3.6e-05 22.1 0.0 0.0058 14.9 0.0 3.4 3 1 1 4 4 4 1 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.3 T189550_1 - 4.2e-05 22.9 1.4 2.2 7.4 0.0 5.7 5 1 1 6 6 6 2 WD40-like domain Cytochrom_D1 PF02239.14 T189550_1 - 0.00017 20.1 9.0 0.25 9.7 0.0 5.6 6 1 1 7 7 7 2 Cytochrome D1 heme domain PD40 PF07676.10 T189550_1 - 0.00061 19.5 0.0 78 3.3 0.0 6.0 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Nup160 PF11715.6 T189550_1 - 0.067 11.7 0.1 35 2.7 0.0 3.9 4 0 0 4 4 4 0 Nucleoporin Nup120/160 HELP PF03451.12 T189550_2 - 8.4e-20 70.3 0.4 1.5e-19 69.5 0.4 1.4 1 0 0 1 1 1 1 HELP motif WD40 PF00400.30 T189550_3 - 0.00016 22.2 0.6 0.00077 20.1 0.6 2.2 1 0 0 1 1 1 1 WD domain, G-beta repeat NDK PF00334.17 T150675_1 - 4.4e-54 182.0 0.0 5.9e-54 181.6 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase NDK PF00334.17 T150675_2 - 2.1e-53 179.8 0.0 3.3e-53 179.2 0.0 1.3 1 0 0 1 1 1 1 Nucleoside diphosphate kinase S_100 PF01023.17 T021319_2 - 7.8e-67 220.6 13.7 9.3e-18 63.5 0.5 4.3 4 0 0 4 4 4 4 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 T021319_2 - 7.4e-15 55.1 16.0 3.2e-05 24.2 0.4 4.2 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.30 T021319_2 - 3.1e-09 35.6 14.0 0.092 12.2 0.1 5.2 6 0 0 6 6 6 4 EF hand EF-hand_4 PF12763.5 T021319_2 - 0.00032 20.5 1.8 0.25 11.2 0.0 3.6 4 0 0 4 4 4 1 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.4 T021319_2 - 0.0039 16.8 7.7 0.76 9.5 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.7 T021319_2 - 0.44 10.7 9.5 9.1 6.5 0.1 4.0 4 0 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_6 PF13405.4 T021319_2 - 1.3 9.0 10.0 60 3.8 0.0 5.8 7 0 0 7 7 7 0 EF-hand domain S_100 PF01023.17 T021319_3 - 9.3e-17 60.3 0.3 1.5e-16 59.7 0.3 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 T021319_3 - 0.0045 17.3 0.3 0.007 16.7 0.3 1.2 1 0 0 1 1 1 1 EF-hand domain pair PI3_PI4_kinase PF00454.25 T066964_3 - 4.2e-51 174.0 0.2 1.3e-50 172.5 0.2 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.21 T066964_3 - 1.3e-44 152.7 17.1 2.8e-44 151.6 17.1 1.6 1 0 0 1 1 1 1 FAT domain TAN PF11640.6 T066964_3 - 9.1e-26 90.7 3.0 9.1e-26 90.7 3.0 3.6 3 0 0 3 3 3 1 Telomere-length maintenance and DNA damage repair FATC PF02260.18 T066964_3 - 4.5e-12 45.4 0.0 1.2e-11 44.1 0.0 1.8 1 0 0 1 1 1 1 FATC domain HEAT PF02985.20 T066964_3 - 0.017 15.2 0.6 32 5.0 0.0 4.1 3 0 0 3 3 3 0 HEAT repeat BNR_2 PF13088.4 T301232_1 - 1.3e-47 162.3 0.0 2.3e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 BNR repeat-like domain Ank_2 PF12796.5 T301232_1 - 8.4e-38 128.7 2.4 6.1e-13 49.0 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 T301232_1 - 6.4e-32 108.5 5.0 3.4e-06 27.1 0.1 6.6 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.4 T301232_1 - 8.2e-30 102.7 4.7 8.6e-12 45.2 0.0 4.2 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 T301232_1 - 1.5e-25 88.7 10.1 2.7e-07 30.6 0.0 7.2 2 1 5 7 7 7 6 Ankyrin repeats (many copies) SET PF00856.26 T301232_1 - 1.4e-24 87.2 0.4 4e-23 82.5 0.1 2.4 2 0 0 2 2 2 1 SET domain Ank_3 PF13606.4 T301232_1 - 1.2e-22 77.4 5.0 0.0026 18.0 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeat Pre-SET PF05033.14 T301232_1 - 1.3e-14 54.6 14.9 1.3e-14 54.6 14.9 2.8 2 0 0 2 2 2 1 Pre-SET motif BNR_3 PF13859.4 T301232_1 - 8.6e-12 44.8 0.2 2.2e-11 43.5 0.0 1.6 2 0 0 2 2 1 1 BNR repeat-like domain CDC45 PF02724.12 T301232_1 - 0.0023 16.2 14.7 0.0034 15.6 14.7 1.1 1 0 0 1 1 1 1 CDC45-like protein Paf1 PF03985.11 T301232_1 - 0.1 11.5 16.1 0.15 10.9 16.1 1.1 1 0 0 1 1 1 0 Paf1 RNA_pol_3_Rpc31 PF11705.6 T301232_1 - 0.16 12.0 14.6 0.3 11.1 14.6 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.10 T301232_1 - 0.59 8.1 18.4 0.86 7.6 18.4 1.1 1 0 0 1 1 1 0 Nop14-like family AAA_23 PF13476.4 T301232_1 - 0.96 9.8 5.8 1.6 9.1 5.8 1.2 1 0 0 1 1 1 0 AAA domain XRCC4 PF06632.10 T301232_1 - 1.2 7.7 13.4 2 7.0 13.4 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 SDA1 PF05285.10 T301232_1 - 4.4 6.5 22.8 7.3 5.8 22.8 1.2 1 0 0 1 1 1 0 SDA1 Choline_transpo PF04515.10 T301232_3 - 7.5e-95 317.7 24.9 7.5e-95 317.7 24.9 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter BTB PF00651.29 T301232_3 - 9.4e-21 74.0 0.6 1.4e-20 73.5 0.6 1.2 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 T301232_3 - 5.3e-09 35.9 33.0 0.00011 22.4 2.8 5.8 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T301232_3 - 5.4e-05 23.3 26.8 0.00064 19.9 1.3 5.9 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 T301232_3 - 0.039 14.6 46.3 0.079 13.7 1.9 6.1 5 0 0 5 5 5 0 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T301232_3 - 0.13 11.9 17.8 0.0068 16.0 1.0 3.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.5 T301232_3 - 0.14 12.3 14.8 3.3 8.0 9.4 2.8 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Surp PF01805.18 T170826_3 - 5e-16 58.3 0.2 3.8e-10 39.5 0.2 2.5 2 0 0 2 2 2 2 Surp module G-patch PF01585.21 T170826_3 - 7.3e-15 54.5 3.4 1.5e-14 53.5 3.4 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 T170826_3 - 0.00031 20.6 1.0 0.00075 19.4 1.0 1.6 1 0 0 1 1 1 1 G-patch domain DUF4472 PF14739.4 T124442_2 - 2.3e-30 105.4 0.9 3.7e-30 104.7 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4472) CAGE1 PF15066.4 T124442_3 - 0.043 12.3 0.1 0.066 11.7 0.1 1.1 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family AAR2 PF05282.9 T217149_1 - 4e-105 352.0 0.0 5.1e-105 351.6 0.0 1.1 1 0 0 1 1 1 1 AAR2 protein 4_1_CTD PF05902.11 T217149_2 - 4.1e-32 110.4 3.1 7.4e-32 109.6 3.1 1.4 1 0 0 1 1 1 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.8 T217149_2 - 2.9e-24 85.2 0.0 5.3e-24 84.3 0.0 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain SAB PF04382.11 T217149_2 - 1.6e-21 76.0 3.1 3.9e-21 74.7 3.1 1.7 1 0 0 1 1 1 1 SAB domain FERM_N PF09379.8 T217149_2 - 1.1e-19 70.0 0.1 2.5e-19 68.8 0.1 1.7 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.16 T217149_2 - 1.3e-19 70.6 0.0 2.9e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 FERM central domain FA PF08736.9 T217149_2 - 1.4e-17 63.3 2.6 4.1e-17 61.9 2.6 1.9 1 0 0 1 1 1 1 FERM adjacent (FA) Hormone_3 PF00159.16 T148368_1 - 1.7e-17 63.1 4.2 2.9e-17 62.3 4.2 1.4 1 0 0 1 1 1 1 Pancreatic hormone peptide TMEM101 PF15111.4 T148368_2 - 3.6e-99 331.2 1.3 5.1e-99 330.7 1.3 1.1 1 0 0 1 1 1 1 TMEM101 protein family CSTF2_hinge PF14327.4 T377625_2 - 8.6e-30 102.9 3.7 1.6e-29 102.1 3.7 1.4 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.20 T377625_2 - 5.5e-25 86.8 0.0 1.1e-24 85.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.4 T377625_2 - 2.9e-18 65.0 10.0 2.9e-18 65.0 10.0 2.2 3 0 0 3 3 3 1 Transcription termination and cleavage factor C-terminal RRM_7 PF16367.3 T377625_2 - 0.098 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif cobW PF02492.17 T197194_2 - 4e-43 146.9 0.1 6e-43 146.3 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.12 T197194_2 - 1.9e-16 59.6 0.0 3.3e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain DUF258 PF03193.14 T197194_2 - 0.0062 16.3 0.1 3.1 7.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 TNFR_c6 PF00020.16 T375757_3 - 2.7e-11 43.6 29.7 6.6e-07 29.5 7.6 3.7 3 0 0 3 3 3 2 TNFR/NGFR cysteine-rich region FAM27 PF15832.3 T375757_3 - 0.46 10.9 5.5 0.87 10.0 5.5 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family C2 PF00168.28 T119459_2 - 3.3e-07 30.4 0.1 1.7e-05 24.9 0.1 2.4 2 0 0 2 2 2 2 C2 domain HCR PF07111.10 T300820_3 - 0 1439.0 109.1 0 1406.9 106.2 2.0 2 0 0 2 2 2 2 Alpha helical coiled-coil rod protein (HCR) SpoVIF PF14069.4 T300820_3 - 0.16 11.6 7.0 0.04 13.6 1.7 2.7 3 0 0 3 3 3 0 Stage VI sporulation protein F Synaphin PF05835.10 T119631_2 - 2.3e-44 151.0 8.4 3.2e-44 150.5 8.4 1.2 1 0 0 1 1 1 1 Synaphin protein Lectin_leg-like PF03388.11 T119631_2 - 4.3e-41 140.6 0.0 6.4e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family HLH PF00010.24 T165761_1 - 8.8e-10 38.3 1.1 1.6e-09 37.5 1.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF4349 PF14257.4 T165761_1 - 0.14 11.5 3.0 0.21 10.9 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) CDC45 PF02724.12 T165761_1 - 0.76 7.9 6.0 1.1 7.4 6.0 1.0 1 0 0 1 1 1 0 CDC45-like protein ASH PF15780.3 T240290_1 - 2.2e-10 40.5 0.0 5.6 7.1 0.0 7.2 8 0 0 8 8 8 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.6 T240290_1 - 0.0047 16.9 1.2 1.1 9.2 0.1 4.3 5 0 0 5 5 5 1 Transmembrane protein 131-like PapD-like PF14874.4 T240290_1 - 0.011 15.8 0.1 21 5.2 0.0 3.9 4 0 0 4 4 4 0 Flagellar-associated PapD-like DUF1978 PF09321.8 T240290_2 - 0.25 10.5 7.0 0.012 14.8 1.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1978) Vir_act_alpha_C PF10400.7 T240290_2 - 0.44 11.1 4.4 0.21 12.1 1.5 1.9 2 0 0 2 2 2 0 Virulence activator alpha C-term PriCT_2 PF08707.9 T035336_1 - 0.05 13.9 0.0 78 3.6 0.0 3.5 1 1 5 6 6 6 0 Primase C terminal 2 (PriCT-2) NUDIX PF00293.26 T035336_2 - 4.2e-24 84.9 0.0 7.1e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DDE_1 PF03184.17 T035336_2 - 7.3e-09 35.3 0.0 1.6e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease SIT PF15330.4 T154060_1 - 1.5e-33 115.4 0.7 2.5e-33 114.8 0.7 1.4 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT V-set PF07686.15 T154060_1 - 1.6e-11 44.2 0.9 2.7e-11 43.5 0.9 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain TMEM154 PF15102.4 T154060_1 - 0.029 14.1 0.1 0.029 14.1 0.1 1.6 2 0 0 2 2 2 0 TMEM154 protein family ig PF00047.23 T154060_1 - 0.68 10.0 2.7 2.7 8.1 2.7 1.9 1 1 0 1 1 1 0 Immunoglobulin domain DUF3105 PF11303.6 T144875_2 - 0.05 13.6 0.1 0.092 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3105) Pkinase PF00069.23 T291224_3 - 2e-22 79.7 0.0 3e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T291224_3 - 2.1e-09 36.9 0.0 3.5e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SPICE PF15678.3 T248306_2 - 7.6e-159 529.4 22.6 1e-158 529.0 22.6 1.1 1 0 0 1 1 1 1 Centriole duplication and mitotic chromosome congression DivIC PF04977.13 T248306_2 - 0.36 10.5 1.8 0.88 9.2 1.8 1.6 1 0 0 1 1 1 0 Septum formation initiator WD40 PF00400.30 T248306_3 - 7.9e-14 51.7 0.1 0.013 16.2 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T248306_3 - 6e-06 26.3 0.0 1.2 9.3 0.0 5.6 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain FYDLN_acid PF09538.8 T248306_3 - 0.56 10.8 9.2 17 6.0 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Neur_chan_memb PF02932.14 T274780_1 - 2.1e-07 31.1 0.1 3.9e-07 30.3 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region BEN PF10523.7 T138018_1 - 1.2e-07 31.7 0.0 2.7e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 BEN domain DUF1845 PF08900.9 T138018_1 - 0.0084 15.7 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1845) SRF-TF PF00319.16 T170852_1 - 2.9e-22 77.7 0.3 4.8e-22 77.1 0.3 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) NEP PF10167.7 T170852_3 - 5e-39 132.6 0.1 7.8e-39 132.0 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein Metallophos PF00149.26 T266687_1 - 1.1e-25 91.2 0.0 1.6e-20 74.3 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase PPP5 PF08321.10 T266687_1 - 1.6e-07 31.3 0.0 3.9e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region IQ PF00612.25 T266687_1 - 0.0062 16.1 2.7 0.016 14.8 2.7 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif EF-hand_1 PF00036.30 T266687_2 - 4.8e-13 47.5 2.3 1.4e-05 24.2 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.4 T266687_2 - 5.5e-13 49.1 6.4 9e-09 35.6 2.3 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 T266687_2 - 1.9e-11 42.8 1.7 0.0011 18.6 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.4 T266687_2 - 7.6e-08 31.9 2.0 0.0073 15.9 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 T266687_2 - 1.9e-07 30.2 2.6 0.00097 18.4 0.2 2.4 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.7 T266687_2 - 0.14 12.3 2.0 0.34 11.1 1.2 1.9 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF1725 PF08333.9 T266687_3 - 0.016 14.7 1.3 0.031 13.8 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) AF-4 PF05110.11 T381337_1 - 0 1240.1 54.9 3.4e-265 883.3 32.3 2.0 1 1 1 2 2 2 2 AF-4 proto-oncoprotein AhpC-TSA_2 PF13911.4 T363244_2 - 1.7e-11 44.1 0.0 3e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.19 T363244_2 - 0.11 12.3 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family PSP PF04046.14 T363244_2 - 3.7 7.4 6.9 3.9 7.3 2.0 2.6 1 1 1 2 2 2 0 PSP SAM_1 PF00536.28 T054198_2 - 4.5e-38 129.4 3.0 5.5e-17 61.8 0.0 3.9 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T054198_2 - 7.9e-38 128.3 0.9 1.1e-15 57.3 0.0 3.5 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) Reo_sigmaC PF04582.10 T054198_2 - 0.33 10.2 7.9 1.4 8.1 4.0 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF16 PF01519.14 T054198_2 - 6.9 7.1 19.7 0.026 14.9 2.4 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 HOOK PF05622.10 T169011_1 - 1.1e-18 66.7 0.0 1.6e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 HOOK protein HOOK PF05622.10 T169011_2 - 3.4e-255 848.4 65.9 4.6e-255 848.0 65.9 1.1 1 0 0 1 1 1 1 HOOK protein T2SSF PF00482.21 T169011_2 - 7.3 6.4 10.1 1.1 9.0 4.9 2.0 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein F Nucleoside_tran PF01733.16 T304368_1 - 1.8e-130 434.7 7.9 3.1e-130 434.0 7.9 1.4 1 0 0 1 1 1 1 Nucleoside transporter DUF2157 PF09925.7 T304368_1 - 1.5 8.5 8.4 4.3 7.0 8.4 1.8 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) UPAR_LY6 PF00021.19 T176617_3 - 7.4e-24 84.1 47.7 1.1e-11 45.1 6.7 3.8 3 0 0 3 3 3 3 u-PAR/Ly-6 domain Toxin_1 PF00087.19 T176617_3 - 1.5 9.0 41.7 0.55 10.4 7.8 4.2 3 0 0 3 3 3 0 Snake toxin Methyltransf_32 PF13679.4 T022635_2 - 3.5e-30 104.9 0.1 4.9e-30 104.5 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T022635_2 - 0.083 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TRM13 PF05206.12 T022635_2 - 0.098 12.0 0.0 6.3 6.1 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase TRM13 RrnaAD PF00398.18 T022635_2 - 0.14 11.1 0.1 0.21 10.5 0.1 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PAH PF02671.19 T022199_3 - 6.3e-10 38.9 5.6 3.2e-06 27.0 0.7 3.4 3 0 0 3 3 3 2 Paired amphipathic helix repeat Myb_DNA-bind_6 PF13921.4 T022199_3 - 7.7e-05 22.7 0.0 0.0007 19.6 0.0 2.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.29 T022199_3 - 0.02 14.9 0.0 0.12 12.4 0.0 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain CtnDOT_TraJ PF07863.9 T022199_3 - 0.11 13.0 0.2 0.26 11.8 0.2 1.6 1 0 0 1 1 1 0 Homologues of TraJ from Bacteroides conjugative transposon SLT_2 PF13406.4 T022199_3 - 0.38 9.8 1.6 18 4.3 0.0 2.5 2 0 0 2 2 2 0 Transglycosylase SLT domain DUF2789 PF10982.6 T022199_3 - 0.46 10.6 3.0 1.2 9.2 3.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2789) 7tm_1 PF00001.19 T241043_2 - 2.1e-10 40.2 1.6 3.7e-10 39.3 1.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) mit_SMPDase PF14724.4 T199103_2 - 0 1538.2 0.3 0 1538.0 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial-associated sphingomyelin phosphodiesterase TPR_19 PF14559.4 T240467_1 - 2.7e-09 37.3 3.5 0.021 15.2 0.0 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 T240467_1 - 6.3e-08 32.7 0.0 5.7 7.9 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.15 T240467_1 - 0.00051 19.8 13.0 1.1 9.5 0.0 5.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.4 T240467_1 - 0.0016 18.8 5.5 6.5 7.5 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.26 T240467_1 - 0.0017 18.0 5.7 1.5 8.6 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 T240467_1 - 0.011 15.9 0.5 4.5 7.5 0.3 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.7 T240467_1 - 0.051 13.2 0.6 0.082 12.5 0.6 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_8 PF13181.4 T240467_1 - 0.17 12.0 1.4 5.8 7.3 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.5 T240467_1 - 0.69 10.0 10.1 0.72 10.0 2.7 3.7 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.4 T240467_2 - 4.3e-27 94.3 24.2 8.3e-06 26.1 0.9 10.9 9 2 2 11 11 11 5 Tetratricopeptide repeat TPR_2 PF07719.15 T240467_2 - 1.1e-25 87.5 33.1 0.0014 18.4 0.5 13.6 13 0 0 13 13 13 7 Tetratricopeptide repeat TPR_14 PF13428.4 T240467_2 - 1.4e-22 78.3 12.7 0.019 15.6 0.0 12.6 7 3 6 14 14 14 6 Tetratricopeptide repeat TPR_16 PF13432.4 T240467_2 - 2.1e-19 69.8 4.0 0.0045 17.5 1.4 9.9 11 1 0 11 11 9 2 Tetratricopeptide repeat TPR_1 PF00515.26 T240467_2 - 5.4e-16 57.5 51.3 0.00016 21.2 0.4 13.6 15 0 0 15 15 15 6 Tetratricopeptide repeat ANAPC3 PF12895.5 T240467_2 - 7e-16 58.1 21.6 0.0013 18.8 3.0 8.6 7 2 1 8 8 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.4 T240467_2 - 1.3e-13 50.9 21.5 0.0079 16.3 0.6 10.4 9 1 0 10 10 10 3 Tetratricopeptide repeat TPR_8 PF13181.4 T240467_2 - 2.1e-12 46.1 34.2 0.0076 16.3 0.4 11.3 13 0 0 13 13 12 3 Tetratricopeptide repeat TPR_11 PF13414.4 T240467_2 - 3.5e-12 45.7 26.8 0.027 14.0 0.1 8.8 9 1 1 10 10 8 5 TPR repeat TPR_6 PF13174.4 T240467_2 - 7.9e-06 26.1 28.2 1.5 9.5 0.0 10.5 13 0 0 13 13 9 2 Tetratricopeptide repeat TPR_17 PF13431.4 T240467_2 - 9.7e-06 25.5 5.8 0.53 10.7 0.0 6.7 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_7 PF13176.4 T240467_2 - 2.7e-05 23.7 22.1 1.6 8.8 0.6 9.7 9 1 1 10 10 9 2 Tetratricopeptide repeat TPR_9 PF13371.4 T240467_2 - 0.00018 21.4 2.7 0.35 10.9 0.1 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 T240467_2 - 0.0004 20.3 9.6 0.091 12.7 0.0 5.5 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.12 T240467_2 - 0.0081 16.6 4.4 16 6.3 0.3 5.3 5 0 0 5 5 4 0 Tetratricopeptide repeat NARP1 PF12569.6 T240467_2 - 0.012 14.3 16.4 0.88 8.2 0.0 4.7 3 3 1 4 4 4 0 NMDA receptor-regulated protein 1 SRP_TPR_like PF17004.3 T240467_2 - 0.051 13.5 8.4 0.66 9.9 0.5 4.5 4 1 0 4 4 4 0 Putative TPR-like repeat TPR_15 PF13429.4 T240467_2 - 0.17 10.9 8.8 6.1 5.8 0.0 5.1 3 1 2 6 6 6 0 Tetratricopeptide repeat SPOB_a PF14689.4 T240467_2 - 0.26 10.9 2.3 15 5.2 0.0 3.6 3 0 0 3 3 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_20 PF14561.4 T240467_2 - 0.53 10.5 9.3 23 5.2 0.1 5.8 5 1 1 7 7 6 0 Tetratricopeptide repeat SNAP PF14938.4 T240467_2 - 0.66 9.2 11.4 4.7 6.4 0.3 4.1 3 1 0 4 4 4 0 Soluble NSF attachment protein, SNAP Ig_3 PF13927.4 T067762_1 - 8.5e-27 93.5 0.3 8.9e-12 45.3 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T067762_1 - 1.3e-23 83.0 0.4 9.1e-09 35.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T067762_1 - 1e-22 79.9 0.2 2.5e-10 40.1 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 T067762_1 - 7.9e-20 70.7 1.6 3.7e-08 33.3 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T067762_1 - 1.3e-14 54.2 3.5 5e-07 29.7 0.1 4.4 3 1 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 T067762_1 - 4.1e-13 49.1 0.1 2.5e-12 46.6 0.0 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 T067762_1 - 0.00072 19.4 0.0 1.6 8.7 0.0 2.6 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain C1-set PF07654.13 T067762_1 - 0.0025 18.1 0.3 0.056 13.8 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Adeno_E3_CR1 PF02440.13 T067762_1 - 0.065 12.9 2.0 11 5.8 0.0 3.5 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 DUF2207 PF09972.7 T067762_1 - 0.11 11.1 0.0 0.19 10.3 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3439 PF11921.6 T067762_1 - 3.2 7.6 8.1 6.6 6.6 8.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Gtr1_RagA PF04670.10 T375339_3 - 5.8e-105 349.6 1.6 8e-105 349.2 1.6 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.11 T375339_3 - 7.3e-06 26.1 0.7 0.0024 18.0 0.5 2.5 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 T375339_3 - 7.4e-06 25.5 0.9 0.00036 20.0 0.9 2.3 1 1 0 1 1 1 1 Ras family Arf PF00025.19 T375339_3 - 2.6e-05 23.6 0.7 0.00014 21.2 0.5 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 T375339_3 - 0.0018 18.2 0.0 0.0054 16.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.25 T375339_3 - 0.11 12.8 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 ABC transporter PduV-EutP PF10662.7 T375339_3 - 0.13 11.9 0.1 0.28 10.8 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.18 T375339_3 - 8 5.4 7.8 8.4 5.3 0.5 2.5 2 1 0 3 3 3 0 G-protein alpha subunit Trypsin PF00089.24 T179576_2 - 3.2e-205 677.7 8.6 7.2e-72 241.6 2.4 3.2 3 0 0 3 3 3 3 Trypsin Trypsin_2 PF13365.4 T179576_2 - 2e-17 64.3 0.2 1.9e-07 31.9 0.2 3.5 3 0 0 3 3 3 3 Trypsin-like peptidase domain DUF1986 PF09342.9 T179576_2 - 5e-09 36.4 0.0 0.0078 16.5 0.0 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF1986) Peptidase_C31 PF05410.11 T179576_2 - 0.059 13.3 0.5 2 8.4 0.1 2.9 3 0 0 3 3 3 0 Porcine arterivirus-type cysteine proteinase alpha Trypsin PF00089.24 T179576_3 - 1.6e-56 191.4 0.1 2.9e-56 190.6 0.1 1.4 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 T179576_3 - 0.0081 16.4 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) COMPASS-Shg1 PF05205.10 T261521_3 - 3.4e-24 85.4 0.0 3.4e-24 85.4 0.0 4.1 3 1 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component shg1 AT_hook PF02178.17 T261521_3 - 1.2 9.1 8.4 0.22 11.4 4.1 2.2 2 0 0 2 2 2 0 AT hook motif ASCH PF04266.12 T381478_1 - 0.053 14.0 0.0 0.086 13.3 0.0 1.3 1 0 0 1 1 1 0 ASCH domain Autophagy_act_C PF03987.13 T369697_1 - 0.034 14.6 0.0 0.11 13.0 0.0 1.9 1 0 0 1 1 1 0 Autophagocytosis associated protein, active-site domain NUDIX PF00293.26 T019446_1 - 1.1e-15 57.7 0.0 2.2e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF1725 PF08333.9 T019446_1 - 4.3e-05 22.9 0.5 0.0001 21.7 0.5 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) HTH_9 PF08221.9 T019446_2 - 2e-19 69.3 0.7 3.1e-19 68.7 0.7 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain RNA_pol_Rpc82 PF05645.11 T019446_3 - 3.1e-42 145.0 0.0 9.1e-42 143.5 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 IL8 PF00048.18 T167463_3 - 7.9e-17 61.0 0.1 1.7e-16 60.0 0.1 1.6 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like dCMP_cyt_deam_1 PF00383.21 T312853_3 - 1.1e-16 60.4 1.6 1.1e-16 60.4 1.6 2.0 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 T312853_3 - 2.4e-16 59.6 0.0 4.3e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.4 T312853_3 - 0.14 12.1 0.2 0.29 11.0 0.2 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase Ion_trans PF00520.29 T022063_3 - 8.7e-23 80.7 10.6 1.4e-22 80.0 10.6 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_N PF08412.8 T022063_3 - 9.9e-20 69.8 0.0 1.8e-19 68.9 0.0 1.5 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.27 T022063_3 - 9.3e-16 57.5 0.0 1.9e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 T022063_3 - 0.00066 19.5 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 Ion channel HSF_DNA-bind PF00447.15 T134300_1 - 6.8e-23 81.0 0.2 1.1e-22 80.2 0.2 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding CARD PF00619.19 T134300_1 - 5.2e-17 61.5 0.0 8.6e-17 60.8 0.0 1.4 1 0 0 1 1 1 1 Caspase recruitment domain F-box-like PF12937.5 T134300_1 - 1.5e-09 37.5 0.1 3.8e-09 36.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T134300_1 - 1.6e-06 27.7 0.0 5.2e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 F-box domain Trypan_PARP PF05887.9 T134300_1 - 6.5 6.6 51.5 0.037 13.9 41.3 2.2 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) ALS2CR8 PF15299.4 T206028_3 - 4.7e-61 206.3 0.8 7e-61 205.8 0.8 1.2 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Tubulin-binding PF00418.17 T149091_2 - 3.2e-41 138.9 16.7 9.5e-15 54.2 0.3 4.5 4 0 0 4 4 4 3 Tau and MAP protein, tubulin-binding repeat DUF1633 PF07794.9 T069425_1 - 0.036 12.1 0.8 0.052 11.6 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) FYRC PF05965.12 T069425_2 - 4.8e-18 65.0 0.0 8.2e-18 64.2 0.0 1.4 1 0 0 1 1 1 1 F/Y rich C-terminus FYRN PF05964.12 T069425_2 - 1.5e-17 63.1 0.6 3.1e-17 62.0 0.6 1.6 1 0 0 1 1 1 1 F/Y-rich N-terminus Innexin PF00876.16 T069425_3 - 4.5e-08 32.7 0.1 7.6e-08 31.9 0.1 1.2 1 0 0 1 1 1 1 Innexin 7tm_2 PF00002.22 T337359_2 - 1.4e-10 40.8 0.1 2e-10 40.3 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) ELMO_CED12 PF04727.11 T192973_2 - 1.4e-17 64.2 0.0 2.5e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family ELMO_CED12 PF04727.11 T192973_3 - 1.4e-05 25.1 0.1 2.5e-05 24.3 0.1 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family SWIB PF02201.16 T336022_2 - 3.4e-15 55.5 0.0 6.2e-15 54.7 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain fn3 PF00041.19 T104316_1 - 9.4e-09 35.4 0.0 1.8e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-B_box PF00643.22 T104316_1 - 2.8e-06 27.2 8.3 2.8e-06 27.2 8.3 6.5 6 0 0 6 6 6 2 B-box zinc finger zf-C3HC4_3 PF13920.4 T104316_1 - 3.6e-06 26.6 1.8 3.6e-06 26.6 1.8 6.5 7 0 0 7 7 7 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T104316_1 - 6.3e-06 25.8 1.9 6.3e-06 25.8 1.9 5.5 6 1 0 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T104316_1 - 1.6e-05 24.6 3.6 1.6e-05 24.6 3.6 3.8 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 T104316_1 - 5.9e-05 23.0 4.5 5.9e-05 23.0 4.5 5.7 7 0 0 7 7 7 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 T104316_1 - 0.0004 20.1 1.4 0.0004 20.1 1.4 6.2 6 0 0 6 6 6 1 zinc-RING finger domain CEBP_ZZ PF16366.3 T104316_1 - 0.0031 17.6 3.9 0.0031 17.6 3.9 3.8 5 0 0 5 5 5 1 Cytoplasmic polyadenylation element-binding protein ZZ domain Trm112p PF03966.14 T104316_1 - 3.4 8.2 7.6 16 6.0 0.1 3.7 2 1 0 2 2 2 0 Trm112p-like protein FUSC PF04632.10 T205299_3 - 0.99 7.7 2.6 1.3 7.3 2.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMF_TATA_bd PF12325.6 T205299_3 - 0.99 9.5 14.9 0.64 10.1 12.3 1.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Reprolysin PF01421.17 T342490_1 - 1.7e-36 125.9 0.0 3.1e-36 125.0 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 T342490_1 - 2.3e-30 105.2 2.6 2.3e-30 105.2 2.6 2.7 3 0 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 T342490_1 - 1.7e-22 80.1 0.1 3e-22 79.2 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 T342490_1 - 3.7e-12 46.7 18.1 3.7e-12 46.7 18.1 3.0 2 0 0 2 2 2 1 Disintegrin Reprolysin_5 PF13688.4 T342490_1 - 0.00022 21.3 0.0 0.00022 21.3 0.0 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T342490_1 - 0.0022 18.4 0.0 0.0048 17.3 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF1510 PF07423.9 T342490_1 - 0.014 14.7 3.2 0.02 14.2 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4834 PF16118.3 T342490_1 - 0.046 14.6 0.3 0.12 13.2 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) hEGF PF12661.5 T342490_1 - 0.091 13.3 6.8 0.7 10.5 6.8 2.7 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.11 T342490_1 - 4 7.7 23.4 0.014 15.6 12.9 2.5 2 0 0 2 2 2 0 EGF-like domain Reprolysin PF01421.17 T342490_3 - 6.3e-70 235.0 0.0 1.2e-69 234.1 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 T342490_3 - 1.3e-32 112.5 5.6 1.3e-32 112.5 5.6 2.6 2 0 0 2 2 1 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 T342490_3 - 6.2e-31 107.4 0.9 1e-30 106.7 0.9 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 T342490_3 - 2.6e-19 70.0 0.1 4.4e-19 69.3 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 T342490_3 - 1.2e-18 67.5 27.1 1.2e-18 67.5 27.1 4.7 5 0 0 5 5 2 1 Disintegrin Reprolysin_3 PF13582.4 T342490_3 - 4.9e-14 52.8 0.0 8.7e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T342490_3 - 7.1e-10 38.7 0.1 1.2e-09 38.0 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T342490_3 - 4.9e-09 36.2 0.2 8.3e-09 35.5 0.2 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.6 T342490_3 - 0.0065 16.0 0.9 0.011 15.2 0.9 1.2 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Peptidase_M66 PF10462.7 T342490_3 - 0.073 11.9 0.3 0.11 11.3 0.3 1.2 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M10 PF00413.22 T342490_3 - 0.12 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Matrixin Peptidase_M43 PF05572.11 T342490_3 - 3.8 7.3 6.6 0.16 11.8 0.2 1.8 2 0 0 2 2 2 0 Pregnancy-associated plasma protein-A HMG_box PF00505.17 T132437_3 - 3.6e-17 62.4 0.5 7.1e-17 61.5 0.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T132437_3 - 4.3e-11 43.1 0.8 4.3e-11 43.1 0.8 2.0 2 0 0 2 2 2 1 HMG-box domain IMUP PF15761.3 T132437_3 - 0.17 12.4 7.4 0.46 11.0 7.4 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein PAT1 PF09770.7 T132437_3 - 2.5 6.1 49.2 4.1 5.4 49.2 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Xan_ur_permease PF00860.18 T289870_1 - 4e-89 298.9 23.9 5.4e-89 298.5 23.9 1.1 1 0 0 1 1 1 1 Permease family SPATA24 PF15175.4 T289870_1 - 3.6e-59 199.6 16.7 8.1e-49 165.8 11.8 2.2 2 0 0 2 2 2 2 Spermatogenesis-associated protein 24 DUF4585 PF15232.4 T289870_2 - 1.6e-20 72.7 1.2 3.6e-20 71.7 1.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4585) ECSCR PF15820.3 T289870_2 - 6.2e-11 41.9 0.7 1.1e-10 41.1 0.7 1.4 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator DUF1977 PF09320.9 T289870_3 - 7.9e-24 83.8 0.8 1.5e-23 82.9 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.29 T289870_3 - 6.8e-23 80.4 0.1 1.2e-22 79.6 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain SPATA24 PF15175.4 T289870_3 - 9.7e-06 25.5 0.8 1.5e-05 24.8 0.8 1.2 1 0 0 1 1 1 1 Spermatogenesis-associated protein 24 Lipocalin PF00061.21 T369776_3 - 4.7e-39 133.7 0.0 2.5e-33 115.2 0.0 2.2 2 0 0 2 2 2 2 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 T369776_3 - 0.026 14.3 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Triabin G-alpha PF00503.18 T242800_3 - 2.7e-109 365.4 0.0 3.1e-109 365.2 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 T242800_3 - 1e-07 31.5 0.0 6.1e-07 28.9 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family G_path_suppress PF15991.3 T140890_1 - 2.5e-88 296.8 20.5 3.4e-88 296.3 20.5 1.2 1 0 0 1 1 1 1 G-protein pathway suppressor MAT1 PF06391.11 T140890_1 - 0.7 9.5 18.0 1.1 8.9 18.0 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF2252 PF10009.7 T140890_1 - 9.8 5.0 9.1 14 4.4 9.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) Neuralized PF07177.10 T140890_3 - 6e-244 798.7 0.0 3.7e-41 140.5 0.0 7.2 7 0 0 7 7 7 7 Neuralized FliMN_C PF01052.18 T140890_3 - 0.18 11.7 0.6 1.8e+02 2.1 0.0 3.9 4 0 0 4 4 4 0 Type III flagellar switch regulator (C-ring) FliN C-term SHIPPO-rpt PF07004.10 T017365_2 - 1.8 9.5 8.4 13 6.7 4.6 2.6 2 0 0 2 2 2 0 Sperm-tail PG-rich repeat TRPM_tetra PF16519.3 T360503_2 - 3.5e-24 84.5 2.0 7.4e-24 83.5 2.0 1.6 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Alpha_kinase PF02816.16 T360503_3 - 1.6e-41 142.5 0.0 2.2e-41 142.0 0.0 1.2 1 0 0 1 1 1 1 Alpha-kinase family Lebercilin PF15619.4 T226299_2 - 8.7e-65 217.9 42.7 8.7e-65 217.9 42.7 2.3 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease Band_3_cyto PF07565.11 T208317_1 - 1.2e-10 41.5 0.0 2e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain HCO3_cotransp PF00955.19 T208317_2 - 3.1e-193 643.2 15.2 2.5e-121 405.9 5.4 3.1 2 1 0 2 2 2 2 HCO3- transporter family Band_3_cyto PF07565.11 T208317_2 - 4.7e-60 203.5 0.0 7.6e-60 202.8 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 T208317_2 - 0.0012 18.6 0.0 0.0018 18.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Band_3_cyto PF07565.11 T208317_3 - 3e-18 66.5 0.0 4.4e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Band 3 cytoplasmic domain zf-Tim10_DDP PF02953.13 T058924_1 - 1e-21 76.2 0.7 1.9e-21 75.4 0.7 1.5 1 0 0 1 1 1 1 Tim10/DDP family zinc finger MFS_1 PF07690.14 T058924_1 - 4.6e-14 52.0 14.8 4.6e-14 52.0 14.8 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily HCV_NS2 PF01538.16 T058924_3 - 0.18 11.3 0.2 0.3 10.6 0.2 1.2 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 Cadherin PF00028.15 T290251_1 - 3.6e-76 251.6 0.0 4.2e-20 71.9 0.0 6.2 6 0 0 6 6 6 5 Cadherin domain Cadherin_2 PF08266.10 T290251_1 - 1.1e-16 60.2 2.9 1.1e-15 57.0 0.3 3.4 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 T290251_1 - 4.3e-06 27.3 0.1 1.2e-05 25.9 0.1 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 T290251_1 - 0.027 14.3 2.5 2.9 7.8 0.2 3.8 3 1 0 4 4 4 0 Cadherin-like Cadherin PF00028.15 T290251_2 - 1.4e-75 249.7 0.0 9.9e-19 67.5 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 T290251_2 - 4.8e-30 103.1 0.2 8e-28 96.0 0.1 3.4 3 0 0 3 3 3 1 Cadherin-like Cadherin_C_2 PF16492.3 T290251_2 - 4.2e-05 24.1 0.0 9.3e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin PF00028.15 T290251_3 - 6.4e-69 228.3 0.0 2.2e-16 59.9 0.1 6.3 5 1 1 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 T290251_3 - 5.8e-63 211.0 4.7 9.7e-63 210.3 4.7 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 T290251_3 - 2.5e-29 100.8 0.4 1.6e-27 95.0 0.2 3.3 3 0 0 3 3 3 1 Cadherin-like Cadherin_C_2 PF16492.3 T290251_3 - 3.9e-05 24.2 2.2 0.00012 22.6 0.1 2.4 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal DUF4958 PF16319.3 T290251_3 - 0.017 13.1 0.0 0.028 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4958) Ldl_recept_b PF00058.15 T269547_3 - 6.6e-41 138.4 5.4 9.6e-10 38.7 0.0 8.9 10 0 0 10 10 10 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 T269547_3 - 2.8e-25 88.2 117.1 3.1e-08 33.6 7.0 9.5 10 0 0 10 10 10 6 Coagulation Factor Xa inhibitory site EGF PF00008.25 T269547_3 - 4e-20 71.6 82.4 0.00012 22.2 2.6 8.8 8 0 0 8 8 8 7 EGF-like domain cEGF PF12662.5 T269547_3 - 1.7e-17 62.9 59.8 6.2e-05 22.7 1.3 8.7 9 0 0 9 9 9 6 Complement Clr-like EGF-like EGF_CA PF07645.13 T269547_3 - 1.9e-14 53.4 18.5 5.2e-10 39.2 6.0 8.5 8 0 0 8 8 8 2 Calcium-binding EGF domain DUF5050 PF16472.3 T269547_3 - 7.4e-11 41.7 0.0 7.8e-05 21.9 0.1 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF5050) EGF_3 PF12947.5 T269547_3 - 9.3e-07 28.8 16.6 1.4e-05 25.1 5.5 8.4 8 1 1 9 9 9 4 EGF domain SGL PF08450.10 T269547_3 - 0.00073 19.1 0.2 9.5 5.6 0.0 4.2 3 2 1 4 4 4 1 SMP-30/Gluconolaconase/LRE-like region HECT PF00632.23 T162789_1 - 2.6e-101 339.0 0.1 3.5e-101 338.6 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 T162789_1 - 1.4e-51 171.9 22.8 9.3e-13 47.8 0.1 5.1 4 0 0 4 4 4 4 WW domain C2 PF00168.28 T162789_1 - 1.9e-25 89.0 0.0 4.5e-25 87.8 0.0 1.6 1 0 0 1 1 1 1 C2 domain PNRC PF15365.4 T193026_2 - 0.0031 17.9 0.4 1.6 9.2 0.3 2.9 2 0 0 2 2 2 2 Proline-rich nuclear receptor coactivator SH2 PF00017.22 T193026_3 - 5.7e-08 32.6 0.0 9.1e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 SH2 domain RS4NT PF08071.10 T193026_3 - 0.0098 15.9 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain Ferric_reduct PF01794.17 T314014_2 - 3e-11 43.4 1.9 5.9e-11 42.5 1.9 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component LRR_4 PF12799.5 T134512_1 - 7.2e-05 22.9 9.8 0.13 12.6 0.1 6.0 3 2 6 9 9 9 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 T134512_1 - 0.049 13.6 18.1 2.2 8.4 0.1 7.4 10 0 0 10 10 10 0 Leucine Rich repeat LRR_8 PF13855.4 T134512_1 - 0.25 11.0 8.1 6.4 6.5 0.3 4.9 3 2 1 5 5 5 0 Leucine rich repeat LRR_4 PF12799.5 T134512_3 - 8.6e-07 29.0 6.7 0.23 11.8 0.0 4.7 3 2 3 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 T134512_3 - 6.7e-05 22.5 9.6 4.1 7.6 0.0 7.2 8 0 0 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.31 T134512_3 - 0.12 12.8 10.5 13 6.6 0.2 6.2 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_8 PF13855.4 T134512_3 - 4.4 7.0 5.7 3.8 7.2 0.1 3.2 2 1 2 4 4 4 0 Leucine rich repeat Ste50p-SAM PF09235.8 T134512_3 - 5.1 7.3 4.7 20 5.4 0.3 3.5 4 0 0 4 4 4 0 Ste50p, sterile alpha motif Nefa_Nip30_N PF10187.7 T133121_1 - 5.7e-31 106.9 20.9 9.3e-31 106.2 20.9 1.4 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Zona_pellucida PF00100.21 T048696_2 - 3.1e-32 112.2 3.5 4.5e-32 111.7 3.5 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain Glyco_transf_41 PF13844.4 T376161_2 - 6.7e-255 845.7 0.0 8.4e-255 845.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 41 TPR_1 PF00515.26 T376161_2 - 2.1e-91 296.2 31.2 6.5e-10 38.3 0.3 13.4 14 0 0 14 14 13 11 Tetratricopeptide repeat TPR_11 PF13414.4 T376161_2 - 1.2e-86 284.0 30.9 2.3e-10 39.8 0.4 12.6 2 2 10 12 12 12 12 TPR repeat TPR_2 PF07719.15 T376161_2 - 4.1e-69 223.1 27.4 6.2e-08 32.0 0.4 12.8 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_17 PF13431.4 T376161_2 - 6.3e-63 204.6 28.9 4.1e-05 23.5 0.1 13.3 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_8 PF13181.4 T376161_2 - 1.7e-61 199.2 14.2 2.6e-06 27.1 0.1 12.8 14 0 0 14 14 12 11 Tetratricopeptide repeat TPR_12 PF13424.4 T376161_2 - 1.3e-45 153.4 26.8 2.9e-10 40.2 0.5 8.9 7 1 2 9 9 8 6 Tetratricopeptide repeat TPR_16 PF13432.4 T376161_2 - 3.7e-42 142.6 14.7 1.5e-08 35.0 0.1 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_14 PF13428.4 T376161_2 - 7.3e-42 138.3 18.4 0.00093 19.7 0.1 11.9 5 3 7 12 12 12 10 Tetratricopeptide repeat TPR_19 PF14559.4 T376161_2 - 8.9e-40 134.9 20.9 9.5e-07 29.1 0.5 9.0 4 4 5 9 9 9 9 Tetratricopeptide repeat TPR_7 PF13176.4 T376161_2 - 2.4e-37 124.0 18.6 0.00016 21.3 0.0 12.4 13 0 0 13 13 11 9 Tetratricopeptide repeat TPR_10 PF13374.4 T376161_2 - 3.3e-35 118.9 46.7 1.6e-06 27.7 0.4 11.9 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_9 PF13371.4 T376161_2 - 8.2e-16 57.8 13.2 0.0026 17.8 0.4 6.6 4 1 2 6 6 6 6 Tetratricopeptide repeat NARP1 PF12569.6 T376161_2 - 3.3e-12 45.9 5.2 0.0036 16.1 0.0 5.3 1 1 4 6 6 6 3 NMDA receptor-regulated protein 1 TPR_6 PF13174.4 T376161_2 - 2.6e-11 43.3 15.6 1.1 9.9 0.0 9.9 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_4 PF07721.12 T376161_2 - 3e-10 39.6 11.6 4 8.2 0.3 9.0 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_15 PF13429.4 T376161_2 - 1.1e-08 34.5 7.5 4.4e-05 22.7 0.5 4.0 1 1 1 4 4 4 2 Tetratricopeptide repeat MIT PF04212.16 T376161_2 - 6.7e-06 26.0 16.3 0.27 11.2 0.1 7.8 6 1 2 8 8 8 1 MIT (microtubule interacting and transport) domain FAT PF02259.21 T376161_2 - 6.9e-06 25.4 0.1 0.64 9.0 0.1 4.7 2 2 1 4 4 4 1 FAT domain Wzy_C_2 PF11846.6 T376161_2 - 8.3e-05 22.5 7.0 0.024 14.4 0.3 4.2 3 1 0 4 4 4 1 Virulence factor membrane-bound polymerase, C-terminal TPR_3 PF07720.10 T376161_2 - 0.0001 22.1 0.2 2.9 7.8 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_21 PF09976.7 T376161_2 - 0.00016 21.4 11.0 0.35 10.5 0.0 4.7 3 2 2 5 5 5 3 Tetratricopeptide repeat-like domain EST1_DNA_bind PF10373.7 T376161_2 - 0.0059 16.0 8.1 1.2 8.4 0.1 4.2 4 0 0 4 4 4 2 Est1 DNA/RNA binding domain SNAP PF14938.4 T376161_2 - 0.0062 15.9 14.2 0.071 12.4 2.7 4.1 1 1 2 4 4 4 2 Soluble NSF attachment protein, SNAP BTAD PF03704.15 T376161_2 - 0.011 16.0 14.1 0.78 10.0 0.5 5.0 3 1 1 4 4 4 0 Bacterial transcriptional activator domain SHNi-TPR PF10516.7 T376161_2 - 0.026 13.9 0.1 30 4.1 0.0 4.5 4 0 0 4 4 4 0 SHNi-TPR RPN7 PF10602.7 T376161_2 - 0.8 9.2 8.6 46 3.5 0.1 5.5 5 2 4 9 9 8 0 26S proteasome subunit RPN7 ANAPC3 PF12895.5 T376161_2 - 3 8.0 16.8 0.23 11.6 1.0 4.3 3 2 2 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.4 T376161_2 - 5.9 7.2 11.6 4.1 7.7 0.1 4.7 5 2 1 6 6 4 0 Tetratricopeptide repeat Glyco_transf_29 PF00777.16 T009563_2 - 1.1e-67 228.1 0.0 1.5e-67 227.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) TGF_beta PF00019.18 T009563_3 - 2.6e-10 41.0 0.0 2.6e-10 41.0 0.0 1.6 2 0 0 2 2 2 1 Transforming growth factor beta like domain Med24_N PF11277.6 T009563_3 - 0.46 8.3 0.7 0.59 7.9 0.7 1.0 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal Lipase PF00151.17 T117327_1 - 1.7e-129 431.8 0.0 2.3e-129 431.4 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 T117327_1 - 3.1e-19 69.5 0.5 4.9e-19 68.9 0.5 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain AAA PF00004.27 T145144_2 - 1e-07 32.3 0.3 5.9e-06 26.6 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 T145144_2 - 0.00062 19.9 0.1 0.0047 17.1 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.4 T145144_2 - 0.0091 16.3 0.1 0.085 13.1 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Ribosomal_S19e PF01090.17 T145144_2 - 0.033 13.7 0.0 0.063 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S19e NTPase_1 PF03266.13 T145144_2 - 0.062 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_14 PF13173.4 T145144_2 - 0.067 13.1 0.5 0.96 9.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.18 T145144_2 - 0.076 11.9 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein Glyco_transf_18 PF15024.4 T155071_1 - 2.1e-132 442.5 1.1 2.8e-132 442.1 1.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 Glyco_transf_18 PF15024.4 T155071_3 - 6.3e-103 345.1 0.0 8.4e-103 344.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 ACAS_N PF16177.3 T155071_3 - 0.14 12.0 0.4 0.31 10.9 0.4 1.6 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus Pkinase PF00069.23 T175499_2 - 1.9e-76 256.8 0.0 2.4e-76 256.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T175499_2 - 1e-35 123.1 0.0 1.4e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Cyclin_N PF00134.21 T175499_2 - 2.4e-23 82.2 0.0 4.2e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain PH PF00169.27 T175499_2 - 1.8e-16 60.4 0.0 3e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.4 T175499_2 - 1.9e-08 33.8 0.0 3.8e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 T175499_2 - 1.6e-07 31.7 0.8 3.2e-07 30.8 0.8 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Cyclin_C PF02984.17 T175499_2 - 0.00083 19.3 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Cyclin, C-terminal domain PAP2 PF01569.19 T355215_1 - 3e-16 59.3 4.6 5e-16 58.6 4.6 1.3 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.4 T355215_1 - 0.00033 20.3 6.9 0.00088 18.9 6.9 1.8 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 T355215_1 - 0.033 14.6 3.1 0.057 13.8 1.3 2.2 2 0 0 2 2 2 0 PAP2 superfamily C-terminal Kinesin PF00225.21 T211393_2 - 4.6e-116 387.3 1.4 6e-116 386.9 1.4 1.2 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.3 T211393_2 - 5.5e-87 290.4 0.5 1.8e-86 288.7 0.5 2.0 1 1 0 1 1 1 1 Kinesin-associated DUF3694 PF12473.6 T211393_2 - 9.7e-38 130.1 0.0 1.8e-37 129.2 0.0 1.5 1 0 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.3 T211393_2 - 4.8e-25 88.1 0.3 1.2e-24 86.8 0.3 1.7 1 0 0 1 1 1 1 Microtubule binding KIF1B PF12423.6 T211393_2 - 2.7e-11 43.7 0.0 2.7e-11 43.7 0.0 2.4 2 0 0 2 2 2 1 Kinesin protein 1B PH PF00169.27 T211393_2 - 2.8e-11 43.7 0.0 1.4e-10 41.4 0.0 2.3 2 0 0 2 2 2 1 PH domain FHA PF00498.24 T211393_2 - 5.4e-07 29.7 0.3 1.7e-06 28.2 0.1 2.0 2 0 0 2 2 2 1 FHA domain DUF3584 PF12128.6 T211393_2 - 1.9 5.7 9.1 3.1 5.0 9.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Mito_carr PF00153.25 T094078_1 - 5.1e-40 135.2 1.3 1.8e-18 66.1 0.0 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.30 T237915_1 - 6.3e-16 58.3 19.6 0.0034 18.1 0.1 6.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T237915_1 - 0.00017 21.6 0.7 0.064 13.4 0.1 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain zf-MYND PF01753.16 T138352_1 - 6.5e-07 29.2 18.5 2.3e-06 27.5 18.5 2.1 1 0 0 1 1 1 1 MYND finger Efg1 PF10153.7 T138352_1 - 0.11 12.7 0.5 0.2 11.9 0.5 1.3 1 0 0 1 1 1 0 rRNA-processing protein Efg1 vATP-synt_E PF01991.16 T138352_1 - 9.6 5.4 8.4 13 4.9 8.4 1.1 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit NHR2 PF08788.9 T138352_2 - 8.4e-36 121.4 8.6 1.9e-35 120.3 8.6 1.6 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 T138352_2 - 3.5e-34 116.6 1.5 5.8e-34 115.9 1.5 1.4 1 0 0 1 1 1 1 NHR1 homology to TAF Ran_BP1 PF00638.16 T196477_2 - 1.6e-225 735.4 21.4 3.3e-57 191.9 2.8 4.5 4 0 0 4 4 4 4 RanBP1 domain zf-RanBP PF00641.16 T196477_2 - 3.9e-82 269.0 104.0 1.4e-11 43.4 3.8 8.6 8 0 0 8 8 8 8 Zn-finger in Ran binding protein and others IR1-M PF12185.6 T196477_2 - 1.2e-51 172.4 8.2 1.2e-26 92.3 2.4 2.6 2 0 0 2 2 2 2 Nup358/RanBP2 E3 ligase domain Pro_isomerase PF00160.19 T196477_2 - 1e-40 139.5 0.7 2.6e-40 138.2 0.7 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WH1 PF00568.21 T196477_2 - 2e-11 43.7 3.9 0.021 14.6 0.1 4.5 4 0 0 4 4 4 4 WH1 domain TPR_1 PF00515.26 T196477_2 - 3.1e-05 23.5 0.0 3.1e-05 23.5 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.15 T196477_2 - 0.00025 20.8 0.0 0.00025 20.8 0.0 3.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_8 PF13181.4 T196477_2 - 0.001 19.0 3.5 0.018 15.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 T196477_2 - 0.0051 17.4 0.1 0.14 12.9 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 T196477_2 - 0.015 15.8 0.0 0.072 13.7 0.0 2.2 3 0 0 3 3 1 0 Tetratricopeptide repeat TPR_19 PF14559.4 T196477_2 - 0.018 15.4 0.1 3.9 7.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.4 T196477_2 - 0.14 12.2 0.0 0.41 10.7 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Pentapeptide PF00805.20 T196477_3 - 0.00092 18.7 0.7 15 5.2 0.0 3.6 3 0 0 3 3 3 3 Pentapeptide repeats (8 copies) DUF1725 PF08333.9 T252870_3 - 0.003 17.0 0.1 0.006 16.1 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Pkinase_Tyr PF07714.15 T259535_1 - 7.5e-103 343.2 0.0 9.4e-103 342.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T259535_1 - 2.2e-43 148.4 0.0 2.8e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 T259535_1 - 0.0051 16.7 0.0 0.011 15.6 0.0 1.5 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T259535_1 - 0.0051 17.3 0.3 0.058 13.9 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 T259535_1 - 0.032 14.3 0.0 0.07 13.2 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain S-antigen PF05756.9 T259535_2 - 3 8.0 7.1 0.44 10.7 0.2 2.1 2 0 0 2 2 2 0 S-antigen protein I-set PF07679.14 T259535_3 - 1.1e-32 111.8 0.0 1.5e-14 53.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 T259535_3 - 1.7e-30 105.4 0.0 8e-12 45.5 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T259535_3 - 1.8e-20 72.9 0.0 4.3e-09 36.5 0.0 4.0 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 T259535_3 - 3.5e-18 65.4 0.0 2.1e-07 30.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T259535_3 - 2.8e-10 40.2 0.0 0.00061 19.8 0.0 4.5 3 2 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 T259535_3 - 0.018 15.0 0.0 0.15 12.0 0.0 2.5 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.9 T259535_3 - 0.16 11.8 0.0 5.2 6.9 0.0 2.3 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Lipocalin PF00061.21 T369471_1 - 6.1e-11 42.6 0.0 8.2e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Laminin_G_2 PF02210.22 T136392_2 - 1.7e-57 193.3 6.0 1.2e-24 87.2 0.1 3.4 3 0 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.21 T136392_2 - 1.8e-32 112.2 0.3 1e-15 57.9 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain F5_F8_type_C PF00754.23 T136392_2 - 2.3e-27 95.5 0.2 2.3e-27 95.5 0.2 1.8 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_3 PF13385.4 T136392_2 - 3.4e-05 23.9 0.0 0.0027 17.8 0.0 2.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.22 T136392_3 - 3.9e-21 75.8 0.0 3.1e-17 63.2 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.21 T136392_3 - 1e-16 61.2 0.0 1.2e-15 57.7 0.0 2.1 2 0 0 2 2 2 1 Laminin G domain Laminin_G_3 PF13385.4 T136392_3 - 0.00024 21.2 0.0 0.00042 20.4 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Voltage_CLC PF00654.18 T003881_3 - 6.2e-74 249.2 23.7 1.1e-73 248.4 23.7 1.4 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.26 T003881_3 - 3e-06 27.5 0.0 0.00019 21.7 0.1 2.6 2 0 0 2 2 2 1 CBS domain Flavi_NS4A PF01350.15 T003881_3 - 0.046 13.5 0.1 0.097 12.5 0.1 1.4 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A DUF3251 PF11622.6 T003881_3 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) RNA_pol_L PF01193.22 T133179_1 - 0.00032 19.9 0.0 0.00046 19.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.24 T133179_3 - 1.7e-39 134.5 0.0 2.5e-39 134.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.22 T133179_3 - 7.4e-05 22.0 0.0 0.00012 21.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Methyltransf_11 PF08241.10 T339323_3 - 2.8e-14 53.4 0.0 4.9e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 T339323_3 - 1.2e-12 48.2 0.0 2e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 T339323_3 - 4.3e-07 30.4 0.0 7.1e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T339323_3 - 8.9e-07 28.7 0.0 1.5e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 T339323_3 - 3.9e-05 23.5 0.1 0.00011 22.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.16 T339323_3 - 0.041 13.1 0.0 0.066 12.4 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family SelP_N PF04592.12 T378731_1 - 4.3 6.5 12.3 6.6 5.9 12.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region TMEM164 PF14808.4 T378731_3 - 4.9e-102 340.5 4.8 7.2e-102 339.9 4.8 1.2 1 0 0 1 1 1 1 TMEM164 family TCTP PF00838.15 T093940_3 - 7.4e-82 273.4 0.6 9.9e-82 273.0 0.6 1.2 1 0 0 1 1 1 1 Translationally controlled tumour protein PID PF00640.21 T165185_2 - 1.3e-46 158.0 0.0 1.8e-46 157.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.22 T165185_2 - 5.6e-16 58.2 0.0 9.3e-16 57.5 0.0 1.4 1 0 0 1 1 1 1 SH2 domain C2 PF00168.28 T165185_2 - 1.8e-06 28.1 0.0 3e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 C2 domain Tho2 PF11262.6 T379667_3 - 8.5e-105 350.1 2.7 8.5e-105 350.1 2.7 4.2 5 2 1 6 6 6 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.3 T379667_3 - 1.8e-90 304.2 8.2 4.9e-64 216.9 5.2 4.0 2 1 1 3 3 3 2 THO complex subunit 2 N-terminus Thoc2 PF11732.6 T379667_3 - 6.4e-37 125.3 0.1 3.6e-36 122.9 0.2 2.2 2 0 0 2 2 2 1 Transcription- and export-related complex subunit FAA_hydrolase PF01557.16 T125155_1 - 2e-60 204.0 0.0 2.8e-60 203.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Gag_spuma PF03276.12 T125155_3 - 9.9e-05 20.8 3.5 0.00014 20.3 3.5 1.1 1 0 0 1 1 1 1 Spumavirus gag protein RNase_Zc3h12a PF11977.6 T313440_3 - 5.1e-65 217.9 0.0 1.1e-64 216.7 0.0 1.6 2 0 0 2 2 2 1 Zc3h12a-like Ribonuclease NYN domain zf-CCCH PF00642.22 T313440_3 - 0.073 12.9 4.2 0.097 12.5 2.4 2.2 1 1 1 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 T313440_3 - 0.36 11.3 6.7 1.1 9.8 6.7 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger GCV_H PF01597.17 T364504_1 - 2.8e-05 23.9 0.0 4.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Glycine cleavage H-protein DDE_Tnp_1_7 PF13843.4 T114083_2 - 9e-113 377.0 0.1 1.2e-112 376.6 0.1 1.1 1 0 0 1 1 1 1 Transposase IS4 Tnp_zf-ribbon_2 PF13842.4 T114083_2 - 2.9e-11 43.8 10.2 1e-10 42.0 10.2 2.1 1 0 0 1 1 1 1 DDE_Tnp_1-like zinc-ribbon zf-B_box PF00643.22 T114083_2 - 1.5 8.9 6.9 4.8 7.3 6.9 1.9 1 0 0 1 1 1 0 B-box zinc finger PurA PF04845.11 T290015_3 - 1.7e-106 354.4 0.0 2.2e-106 354.0 0.0 1.1 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein Nebulin PF00880.16 T038119_2 - 9.5e-149 482.2 106.4 1.2e-09 37.8 0.1 25.4 25 0 0 25 25 25 24 Nebulin repeat SH3_9 PF14604.4 T038119_2 - 4.9e-15 55.0 0.1 8.5e-15 54.2 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T038119_2 - 2.3e-11 43.0 0.0 3.9e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain LIM PF00412.20 T038119_2 - 1e-10 41.6 10.7 1e-10 41.6 10.7 2.5 2 0 0 2 2 2 1 LIM domain SH3_2 PF07653.15 T038119_2 - 0.00036 20.0 0.0 0.00072 19.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ion_trans_2 PF07885.14 T303061_2 - 1.7e-30 104.7 9.0 9.7e-17 60.6 0.4 2.5 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.29 T303061_2 - 0.0001 21.5 7.0 0.0011 18.1 0.6 2.3 2 0 0 2 2 2 2 Ion transport protein Arm PF00514.21 T038876_3 - 1.8e-44 148.3 21.0 3.4e-06 26.8 0.0 11.6 11 0 0 11 11 11 10 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 T038876_3 - 1.7e-19 69.8 3.5 1.3e-05 25.4 0.0 6.6 3 2 3 6 6 6 4 HEAT repeats HEAT_EZ PF13513.4 T038876_3 - 7.3e-11 42.2 7.8 0.0016 18.7 0.3 7.7 6 3 3 9 9 9 4 HEAT-like repeat HEAT PF02985.20 T038876_3 - 2.1e-09 36.7 11.8 0.52 10.6 0.1 8.1 8 0 0 8 8 8 3 HEAT repeat Adaptin_N PF01602.18 T038876_3 - 6.6e-09 34.7 6.4 1.7e-05 23.5 0.2 3.1 2 1 1 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.5 T038876_3 - 5.8e-08 32.8 5.9 0.034 14.0 0.1 4.7 2 1 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.6 T038876_3 - 4.1e-07 29.9 0.8 0.2 11.5 0.1 3.9 2 1 1 3 3 3 2 Myosin-binding striated muscle assembly central KAP PF05804.10 T038876_3 - 1.4e-06 26.7 1.4 0.0062 14.6 0.4 2.2 2 0 0 2 2 2 2 Kinesin-associated protein (KAP) V-ATPase_H_C PF11698.6 T038876_3 - 1.4e-06 28.3 12.0 1.6 8.8 0.5 6.7 4 2 4 8 8 8 2 V-ATPase subunit H RasGEF_N_2 PF14663.4 T038876_3 - 0.0018 18.5 11.3 5.7 7.2 0.0 6.1 6 1 2 8 8 8 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF727 PF05303.10 T038876_3 - 0.0035 17.3 0.0 0.0084 16.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF727) V-ATPase_H_N PF03224.12 T038876_3 - 0.0068 15.6 0.4 2.8 7.0 0.1 3.0 2 1 0 2 2 2 2 V-ATPase subunit H Vac14_Fab1_bd PF12755.5 T038876_3 - 0.079 13.4 0.1 20 5.7 0.0 3.5 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region Homeobox_KN PF05920.9 T132830_3 - 2.5e-15 56.0 0.4 4.8e-15 55.0 0.4 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 T132830_3 - 8.9e-07 28.5 1.1 1.6e-06 27.7 1.1 1.4 1 0 0 1 1 1 1 Homeobox domain Chlamy_scaf PF09675.8 T132830_3 - 0.1 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) V-set_CD47 PF08204.9 T247687_3 - 3.8e-52 175.6 1.0 6.3e-52 174.8 1.0 1.4 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain CD47 PF04549.12 T247687_3 - 9.9e-52 174.9 25.3 2.4e-51 173.6 25.3 1.7 1 0 0 1 1 1 1 CD47 transmembrane region Mit_proteolip PF08039.9 T247687_3 - 0.68 10.2 4.4 1.9 8.8 4.4 1.7 1 0 0 1 1 1 0 Mitochondrial proteolipid Cadherin PF00028.15 T290448_2 - 4.8e-111 363.3 5.0 4.2e-23 81.5 0.0 7.4 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.9 T290448_2 - 1.1e-78 264.1 0.1 1.8e-78 263.4 0.1 1.4 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.10 T290448_2 - 2e-12 46.6 0.0 3.7e-05 23.3 0.0 5.0 5 0 0 5 5 5 3 Cadherin-like Cadherin_3 PF16184.3 T290448_2 - 5.3e-06 26.3 9.7 6.3 6.7 0.0 5.7 6 0 0 6 6 6 3 Cadherin-like DUF4958 PF16319.3 T290448_2 - 2.2e-05 22.7 0.1 0.003 15.6 0.3 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4958) RGCC PF15151.4 T290448_2 - 0.11 12.6 1.0 8.5 6.5 0.4 2.3 2 0 0 2 2 2 0 Response gene to complement 32 protein family Pkinase_Tyr PF07714.15 T355247_3 - 2.3e-148 492.4 0.0 6.9e-85 284.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.23 T355247_3 - 3.3e-73 246.2 0.0 7.5e-50 169.6 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain SH2 PF00017.22 T355247_3 - 5.7e-07 29.4 0.0 1.2e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 SH2 domain FERM_M PF00373.16 T355247_3 - 0.0048 17.2 0.3 0.0097 16.2 0.3 1.5 1 0 0 1 1 1 1 FERM central domain Kinase-like PF14531.4 T355247_3 - 0.0099 15.1 0.0 0.023 13.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like FoP_duplication PF13865.4 T021415_1 - 7.2e-22 77.6 9.1 7.2e-22 77.6 9.1 3.2 1 1 1 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 Tristanin_u2 PF16638.3 T070377_2 - 3.5e-52 176.5 4.0 3.5e-52 176.5 4.0 3.0 3 1 0 3 3 2 1 Unstructured region on methyltransferase between zinc-fingers zf-C2H2 PF00096.24 T070377_2 - 5.3e-30 102.1 78.3 0.00011 22.3 2.5 11.4 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T070377_2 - 5.7e-23 79.5 83.4 0.0093 16.6 1.8 12.2 11 0 0 11 11 10 10 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T070377_2 - 3.3e-15 55.6 66.4 0.0019 18.4 1.6 12.0 11 1 0 11 11 11 8 Zinc-finger double domain zf-C2H2_jaz PF12171.6 T070377_2 - 2.8e-14 52.8 54.5 0.00011 22.3 0.4 10.1 11 0 0 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T070377_2 - 1.9e-06 27.5 50.3 0.0072 16.1 0.4 8.8 8 0 0 8 8 8 4 C2H2-type zinc finger zf-C2H2_2 PF12756.5 T070377_2 - 2.7e-06 27.5 46.7 0.18 12.0 10.0 8.7 4 2 2 7 7 7 4 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 T070377_2 - 4.8e-05 23.5 4.7 0.00099 19.3 0.2 9.6 10 0 0 10 10 9 2 Zinc-finger of C2H2 type zf-Di19 PF05605.10 T070377_2 - 0.065 13.4 42.7 0.11 12.7 2.4 7.6 6 1 1 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding SET PF00856.26 T070377_2 - 0.084 13.1 0.0 0.32 11.2 0.0 2.0 2 0 0 2 2 2 0 SET domain DUF629 PF04780.10 T070377_2 - 0.73 8.2 34.4 0.94 7.8 0.0 6.5 4 1 1 6 6 6 0 Protein of unknown function (DUF629) EMI PF07546.11 T301440_1 - 1.9e-16 60.4 10.2 1.9e-16 60.4 10.2 2.6 2 0 0 2 2 2 1 EMI domain EGF PF00008.25 T301440_1 - 6.6e-05 23.0 7.0 0.00046 20.3 7.0 2.6 1 0 0 1 1 1 1 EGF-like domain Palm_thioest PF02089.13 T301440_3 - 3.3e-14 52.6 0.0 5.1e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.18 T301440_3 - 1.7e-05 24.5 0.1 3e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold FXa_inhibition PF14670.4 T301440_3 - 2.1e-05 24.6 7.9 2.1e-05 24.6 7.9 1.9 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site DUF676 PF05057.12 T301440_3 - 0.0063 15.9 0.0 0.013 14.9 0.0 1.4 1 1 0 1 1 1 1 Putative serine esterase (DUF676) EGF_CA PF07645.13 T301440_3 - 0.024 14.7 5.7 0.055 13.5 5.7 1.6 1 0 0 1 1 1 0 Calcium-binding EGF domain PGAP1 PF07819.11 T301440_3 - 0.046 13.3 0.0 0.12 11.9 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein RAWUL PF16207.3 T146555_3 - 2.7e-21 75.9 0.6 4.8e-21 75.1 0.6 1.4 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 T146555_3 - 5.7e-10 38.7 7.7 1.5e-09 37.4 7.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T146555_3 - 2.1e-09 36.9 8.0 6.8e-09 35.3 8.0 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T146555_3 - 4.4e-06 26.7 6.5 4.4e-06 26.7 6.5 2.5 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.5 T146555_3 - 3.1e-05 24.1 4.0 7.4e-05 22.8 4.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.4 T146555_3 - 3.5e-05 23.5 7.2 3.5e-05 23.5 7.2 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T146555_3 - 0.00042 20.1 6.8 0.00042 20.1 6.8 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 T146555_3 - 0.0022 17.8 4.7 0.007 16.2 4.7 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 T146555_3 - 0.041 13.9 9.2 0.11 12.5 9.2 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.6 T146555_3 - 0.34 10.6 4.2 0.75 9.5 4.2 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Pkinase PF00069.23 T138832_2 - 5.8e-66 222.4 0.0 7e-66 222.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T138832_2 - 1.4e-31 109.6 0.0 1.9e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T138832_2 - 3.3e-07 29.8 0.1 0.00049 19.4 0.0 2.1 1 1 1 2 2 2 2 Kinase-like RIO1 PF01163.20 T138832_2 - 0.042 13.3 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 RIO1 family HJURP_mid PF12346.6 T209986_1 - 1.4e-58 196.3 6.0 4e-58 194.8 6.0 1.9 1 0 0 1 1 1 1 Holliday junction recognition protein-associated repeat HJURP_C PF12347.6 T209986_1 - 1e-47 159.8 2.7 2.2e-23 81.9 0.1 3.2 3 0 0 3 3 3 2 Holliday junction regulator protein family C-terminal repeat Scm3 PF10384.7 T209986_3 - 5e-09 35.6 0.0 7.9e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 Centromere protein Scm3 GAT PF03127.12 T209986_3 - 0.012 15.7 0.0 0.021 15.0 0.0 1.3 1 0 0 1 1 1 0 GAT domain UPF0020 PF01170.16 T188069_2 - 3.3e-25 88.8 0.0 5.7e-25 88.0 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.4 T188069_2 - 5e-09 36.6 0.0 9.1e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T188069_2 - 6.8e-09 35.6 0.0 1.2e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 T188069_2 - 2.1e-07 31.4 0.0 3.6e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 T188069_2 - 1.1e-05 24.8 0.0 1.8e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 T188069_2 - 1.6e-05 24.4 0.0 2.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.10 T188069_2 - 0.0056 17.2 0.0 0.01 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.18 T188069_2 - 0.0063 15.7 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase THUMP PF02926.15 T188069_2 - 0.046 13.7 0.0 0.078 13.0 0.0 1.3 1 0 0 1 1 1 0 THUMP domain AAA PF00004.27 T186054_2 - 7.8e-46 155.6 0.0 4.9e-40 136.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 T186054_2 - 5.5e-06 26.7 0.0 0.0015 18.8 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.15 T186054_2 - 8.7e-05 22.2 0.0 0.00022 20.9 0.0 1.6 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.12 T186054_2 - 0.00043 20.3 0.0 0.0011 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.4 T186054_2 - 0.019 15.1 0.0 0.17 12.0 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.4 T186054_2 - 0.037 14.4 0.9 0.22 11.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.7 T186054_2 - 0.07 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.12 T186054_2 - 0.072 13.0 0.0 0.23 11.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.20 T186054_2 - 0.096 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Bromodomain PF00439.23 T186054_3 - 9.3e-15 54.3 0.5 2.1e-14 53.2 0.5 1.5 1 0 0 1 1 1 1 Bromodomain Aldo_ket_red PF00248.19 T036162_1 - 7.2e-96 320.6 0.0 2e-55 187.9 0.0 2.9 3 0 0 3 3 3 2 Aldo/keto reductase family zf-CCCH PF00642.22 T173918_3 - 2.1e-05 24.2 8.7 0.034 13.9 0.5 2.9 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DFF-C PF09033.8 T002926_1 - 2e-70 235.9 12.0 2.9e-70 235.3 12.0 1.2 1 0 0 1 1 1 1 DNA Fragmentation factor 45kDa, C terminal domain CIDE-N PF02017.13 T002926_1 - 1.9e-23 82.1 0.0 4.7e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 CIDE-N domain Yuri_gagarin PF15934.3 T002926_1 - 0.0051 16.5 1.9 0.037 13.7 1.8 1.9 2 0 0 2 2 2 1 Yuri gagarin COG2 PF06148.9 T002926_1 - 0.26 11.3 1.7 0.43 10.5 1.7 1.2 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 RRM_1 PF00076.20 T007841_2 - 6.3e-29 99.5 0.1 5.1e-14 51.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.9 T007841_2 - 2.6e-27 94.6 1.0 4.3e-27 93.9 1.0 1.4 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.3 T007841_2 - 0.0069 16.4 0.0 0.021 14.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif 2Fe-2S_Ferredox PF11591.6 T031501_3 - 0.83 9.4 7.8 2.6 7.9 7.8 1.8 1 0 0 1 1 1 0 Ferredoxin chloroplastic transit peptide IRK PF01007.18 T225934_3 - 1.9e-117 391.8 1.2 2.6e-117 391.3 1.2 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 T225934_3 - 0.028 14.2 5.9 0.059 13.2 5.9 1.6 1 0 0 1 1 1 0 Ion channel AKAP2_C PF15304.4 T364580_2 - 2.5e-06 26.9 0.2 2.5e-06 26.9 0.2 1.5 2 0 0 2 2 2 1 A-kinase anchor protein 2 C-terminus NKAIN PF05640.12 T310813_2 - 6.6e-38 129.9 0.0 1e-37 129.3 0.0 1.3 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein LIM PF00412.20 T003816_2 - 2.8e-28 97.8 46.1 2.6e-15 56.2 7.0 3.7 4 0 0 4 4 4 3 LIM domain Fucokinase PF07959.10 T135478_2 - 3e-74 250.3 0.0 4e-74 249.9 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase GHMP_kinases_N PF00288.24 T135478_2 - 3.5e-05 23.8 0.2 0.00011 22.3 0.2 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain Fucokinase PF07959.10 T135478_3 - 3.1e-14 52.7 0.0 4.7e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase GHMP_kinases_C PF08544.11 T135478_3 - 2.2e-05 24.6 0.0 4.1e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 GHMP kinases C terminal Peptidase_M10 PF00413.22 T101083_1 - 2.4e-58 196.3 0.0 3.5e-58 195.8 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 T101083_1 - 9.5e-55 182.2 16.0 9.8e-14 50.9 0.3 4.7 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.6 T101083_1 - 7e-24 83.4 0.0 1.3e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.16 T101083_1 - 5e-11 42.5 0.2 1e-10 41.5 0.2 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 T101083_1 - 0.0067 15.9 0.7 1.1 8.7 0.0 2.1 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Metallopep PF12044.6 T101083_1 - 0.071 11.6 0.0 0.1 11.0 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M54 PF07998.9 T101083_1 - 0.077 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 DUF4953 PF16313.3 T101083_1 - 0.11 11.6 0.1 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_3 PF13582.4 T101083_1 - 0.24 11.8 0.1 0.41 11.0 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like SKG6 PF08693.8 T101083_1 - 6.2 6.2 7.1 13 5.2 7.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain zf-H2C2_2 PF13465.4 T174654_1 - 1e-33 114.1 48.8 2.7e-06 27.4 1.0 8.8 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 T174654_1 - 9e-24 82.4 66.8 6.7e-05 23.0 1.4 8.4 8 0 0 8 8 8 6 Zinc finger, C2H2 type KRAB PF01352.25 T174654_1 - 7.7e-23 79.8 0.0 1.6e-22 78.8 0.0 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T174654_1 - 4.3e-06 27.0 73.3 0.0057 17.3 4.3 9.4 9 0 0 9 9 9 6 C2H2-type zinc finger Uroplakin_II PF07353.10 T235155_3 - 0.035 13.5 0.0 0.051 12.9 0.0 1.2 1 0 0 1 1 1 0 Uroplakin II IL8 PF00048.18 T145668_2 - 3.7e-14 52.5 0.4 8.2e-14 51.4 0.4 1.6 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Atrophin-1 PF03154.13 T145668_2 - 1.9 6.5 18.0 2.8 6.0 18.0 1.1 1 0 0 1 1 1 0 Atrophin-1 family Atrophin-1 PF03154.13 T145668_3 - 1.3 7.1 17.8 2.4 6.2 17.8 1.3 1 0 0 1 1 1 0 Atrophin-1 family CCM2_C PF16545.3 T216089_3 - 1.1e-45 154.1 0.1 1.7e-45 153.5 0.1 1.3 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology TP_methylase PF00590.18 T016148_1 - 3.8e-22 79.1 0.0 4.9e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Frag1 PF10277.7 T193179_1 - 5.4e-56 189.4 10.2 5.8e-50 169.7 2.3 2.6 2 0 0 2 2 2 2 Frag1/DRAM/Sfk1 family UPF0561 PF10573.7 T193179_3 - 5.1e-60 200.8 1.0 9.4e-60 199.9 1.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0561 V-set PF07686.15 T212459_1 - 3.2e-13 49.7 0.1 2e-11 43.8 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T212459_1 - 1.1e-07 32.2 0.1 4.2e-07 30.4 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 T212459_1 - 4.8e-06 26.4 0.0 1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 T212459_1 - 9e-06 25.6 0.0 2.6e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 T212459_1 - 7.3e-05 22.9 0.3 0.00022 21.4 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Adeno_E3_CR1 PF02440.13 T212459_1 - 0.0069 16.0 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR1 WD40 PF00400.30 T187686_2 - 1.8e-31 107.6 4.1 5.6e-07 30.0 0.0 7.2 6 0 0 6 6 6 5 WD domain, G-beta repeat Striatin PF08232.10 T187686_2 - 5.7e-26 91.8 1.5 1.6e-25 90.4 1.5 1.8 1 0 0 1 1 1 1 Striatin family ANAPC4_WD40 PF12894.5 T187686_2 - 0.00023 21.2 0.1 0.084 13.1 0.0 3.6 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain DUF3915 PF13054.4 T355966_2 - 0.24 11.2 2.5 0.45 10.4 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Lectin_C PF00059.19 T355966_3 - 1.6e-13 51.2 3.0 1.7e-13 51.1 0.6 2.2 2 0 0 2 2 2 1 Lectin C-type domain Cadherin_3 PF16184.3 T355966_3 - 3e-13 49.6 0.2 6.8e-13 48.5 0.2 1.5 1 0 0 1 1 1 1 Cadherin-like Calx-beta PF03160.12 T355966_3 - 6.7e-07 29.3 0.0 1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Calx-beta domain Med16 PF11635.6 T165387_1 - 7.3e-126 420.9 0.0 9.4e-126 420.5 0.0 1.1 1 0 0 1 1 1 1 Mediator complex subunit 16 WD40 PF00400.30 T165387_1 - 0.00071 20.2 1.3 0.0046 17.7 0.8 2.8 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T165387_1 - 0.013 15.7 0.0 0.17 12.0 0.1 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain RhoGEF PF00621.18 T187994_1 - 3.8e-13 49.9 2.0 3.8e-13 49.9 2.0 2.3 2 0 0 2 2 2 1 RhoGEF domain ArsR PF09824.7 T187994_1 - 0.014 14.9 1.2 0.028 13.9 1.2 1.5 1 0 0 1 1 1 0 ArsR transcriptional regulator Spc7 PF08317.9 T187994_1 - 0.036 12.8 15.6 0.058 12.1 15.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.10 T187994_1 - 0.13 12.1 2.5 0.35 10.7 2.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HAUS6_N PF14661.4 T187994_1 - 0.19 11.2 8.5 0.41 10.1 8.5 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Tup_N PF08581.8 T187994_1 - 0.87 9.8 10.2 0.045 13.9 0.9 2.4 1 1 1 2 2 2 0 Tup N-terminal Muted PF14942.4 T187994_1 - 0.89 9.7 12.4 2 8.6 12.4 1.6 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Exonuc_VII_L PF02601.13 T187994_1 - 1.2 8.5 6.3 2.2 7.7 6.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cluap1 PF10234.7 T187994_1 - 2.2 7.5 13.1 3.6 6.8 13.1 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 COG2 PF06148.9 T187994_1 - 3 7.8 8.6 2.6 8.0 6.2 1.9 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 NEP PF10167.7 T187994_1 - 3.6 7.4 12.4 0.24 11.2 6.4 2.1 2 1 1 3 3 3 0 Uncharacterised conserved protein Seryl_tRNA_N PF02403.20 T187994_1 - 5.2 7.2 13.3 4.7 7.4 10.9 2.1 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain C2 PF00168.28 T086752_2 - 2.5e-40 136.8 0.0 5.5e-19 68.2 0.0 2.4 2 0 0 2 2 2 2 C2 domain RasGAP PF00616.17 T086752_2 - 4.6e-39 134.1 0.0 7.3e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase PH PF00169.27 T086752_2 - 3e-15 56.5 0.0 1.4e-14 54.3 0.0 2.0 2 0 0 2 2 2 1 PH domain BTK PF00779.17 T086752_2 - 5.3e-12 45.2 5.0 1.4e-11 43.9 5.0 1.8 1 0 0 1 1 1 1 BTK motif MIP-T3 PF10243.7 T001179_1 - 0.52 8.8 64.6 0.94 8.0 64.6 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 MIP-T3 PF10243.7 T001179_2 - 3.5e-11 42.4 41.3 4.9e-11 41.9 41.3 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 MIP-T3 PF10243.7 T001179_3 - 0.012 14.3 62.5 0.018 13.7 62.5 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PDEase_I PF00233.17 T311935_2 - 7.1e-75 251.6 2.8 1e-74 251.1 2.8 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF4782 PF16016.3 T248433_3 - 8.8e-34 117.0 0.8 1.5e-33 116.2 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4782) zf-DHHC PF01529.18 T248433_3 - 4.2e-24 85.0 12.0 4.2e-24 85.0 12.0 2.9 3 0 0 3 3 3 1 DHHC palmitoyltransferase TarH PF02203.13 T248433_3 - 0.044 13.6 1.6 0.067 13.0 1.6 1.2 1 0 0 1 1 1 0 Tar ligand binding domain homologue DUF4446 PF14584.4 T248433_3 - 0.26 11.1 1.3 0.55 10.1 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) PDEase_I PF00233.17 T204106_3 - 9.4e-81 270.9 4.8 1.6e-80 270.1 4.8 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.10 T204106_3 - 1.5e-31 107.9 0.1 2.6e-31 107.1 0.1 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal dsrm PF00035.24 T079402_1 - 1.6e-17 63.8 0.1 1.9e-15 57.2 0.0 2.5 3 0 0 3 3 3 1 Double-stranded RNA binding motif DND1_DSRM PF14709.5 T079402_1 - 3.2e-07 30.4 0.7 8.8e-06 25.8 0.1 2.8 2 1 0 2 2 2 1 double strand RNA binding domain from DEAD END PROTEIN 1 Staufen_C PF16482.3 T079402_1 - 6.9e-06 26.1 0.0 1.3e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Staufen C-terminal domain dsrm PF00035.24 T079402_3 - 3.5e-14 53.1 0.0 6.3e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.5 T079402_3 - 0.0081 16.3 0.3 0.026 14.6 0.3 1.8 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 Bombesin PF02044.15 T121224_1 - 9.5e-08 31.4 3.1 2.3e-07 30.2 3.1 1.7 1 0 0 1 1 1 1 Bombesin-like peptide Lectin_C PF00059.19 T073754_2 - 3.1e-14 53.5 0.7 3.1e-14 53.5 0.7 2.1 2 0 0 2 2 2 1 Lectin C-type domain Ly49 PF08391.8 T073754_2 - 0.0022 18.2 1.8 0.0048 17.1 1.8 1.6 1 1 0 1 1 1 1 Ly49-like protein, N-terminal region IncA PF04156.12 T073754_2 - 0.025 14.2 0.9 0.041 13.5 0.9 1.2 1 0 0 1 1 1 0 IncA protein GCSF PF16647.3 T147000_3 - 5.9e-92 305.2 2.6 8.7e-92 304.6 2.6 1.2 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor Ldl_recept_a PF00057.16 T005166_3 - 3e-06 27.2 6.2 3e-06 27.2 6.2 1.9 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Treacle PF03546.12 T291379_3 - 3.1e-236 785.3 206.4 1.8e-176 588.0 124.8 8.1 2 2 4 6 6 6 4 Treacher Collins syndrome protein Treacle Gal-3-0_sulfotr PF06990.9 T291379_3 - 0.05 12.4 0.1 0.079 11.7 0.1 1.2 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase Ubiquitin_3 PF14836.4 T301986_1 - 1.2e-07 31.4 0.0 2.2e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain 7tm_1 PF00001.19 T252126_3 - 1.8e-49 168.3 22.7 1.8e-49 168.3 22.7 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) AAA_33 PF13671.4 T092604_2 - 2.6e-15 56.7 0.0 5.3e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 T092604_2 - 8.3e-05 21.8 0.0 0.0003 20.0 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.4 T092604_2 - 9.6e-05 22.8 0.0 0.00047 20.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.8 T092604_2 - 0.0015 17.9 0.0 0.004 16.5 0.0 1.7 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.4 T092604_2 - 0.0096 16.2 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain TsaE PF02367.15 T092604_2 - 0.24 11.3 0.6 0.83 9.5 0.6 1.9 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Evr1_Alr PF04777.11 T125220_1 - 2.9e-25 88.5 2.4 5.9e-25 87.6 2.4 1.5 1 0 0 1 1 1 1 Erv1 / Alr family KH_1 PF00013.27 T013603_1 - 1e-67 223.7 14.9 7e-18 64.1 0.1 4.2 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 T013603_1 - 3.6e-21 74.7 9.2 1.2e-05 24.9 0.0 4.3 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.8 T013603_1 - 3.7e-11 42.2 21.3 1.1e-06 27.9 5.3 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF1897) KH_4 PF13083.4 T013603_1 - 9.2e-07 28.5 11.0 0.12 12.1 0.1 4.2 4 0 0 4 4 4 3 KH domain Secretin_N PF03958.15 T013603_1 - 0.08 13.2 3.1 0.29 11.4 0.3 2.7 2 2 0 2 2 2 0 Bacterial type II/III secretion system short domain KH_5 PF13184.4 T013603_1 - 0.53 10.3 9.9 15 5.6 0.1 4.0 4 0 0 4 4 4 0 NusA-like KH domain A_deamin PF02137.16 T137182_1 - 3.1e-69 233.8 0.0 4.7e-69 233.2 0.0 1.3 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 T137182_1 - 2e-05 25.1 0.0 3.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif LNS2 PF08235.11 T217949_2 - 2.4e-65 220.0 0.0 3.5e-65 219.5 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_mid PF16876.3 T217949_2 - 6.8e-29 99.9 0.2 1.5e-27 95.6 0.0 2.3 2 0 0 2 2 2 1 Lipin/Ned1/Smp2 multi-domain protein middle domain LNS2 PF08235.11 T217949_3 - 1.5e-30 106.3 0.0 2e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) WRNPLPNID PF15017.4 T217949_3 - 0.0016 19.1 0.1 0.0028 18.4 0.1 1.4 1 0 0 1 1 1 1 Putative WW-binding domain and destruction box zf-H2C2_2 PF13465.4 T107192_3 - 2.7e-21 74.8 33.6 1.7e-07 31.2 0.6 6.2 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.24 T107192_3 - 2e-20 71.9 29.9 8e-05 22.8 1.2 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T107192_3 - 1e-10 41.3 33.6 0.0044 17.6 4.4 5.9 6 0 0 6 6 5 4 C2H2-type zinc finger zf-C2H2_8 PF15909.3 T107192_3 - 0.00031 20.8 5.7 0.11 12.7 1.3 2.9 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_11 PF16622.3 T107192_3 - 0.00031 20.3 14.0 0.63 9.7 2.1 3.6 3 0 0 3 3 3 3 zinc-finger C2H2-type zf-C2HC_2 PF13913.4 T107192_3 - 0.00032 20.4 5.5 0.34 10.7 0.0 4.6 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-C2H2_aberr PF17017.3 T107192_3 - 0.0012 18.9 9.6 3.3 7.7 0.2 4.3 1 1 3 4 4 4 2 Aberrant zinc-finger zf-met PF12874.5 T107192_3 - 0.44 10.9 11.4 11 6.4 0.1 4.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type CpXC PF14353.4 T107192_3 - 0.64 9.9 2.2 3.4 7.6 0.1 2.7 1 1 1 3 3 3 0 CpXC protein zf-C2H2_jaz PF12171.6 T107192_3 - 0.66 10.2 8.0 14 6.0 0.0 4.0 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-DNA_Pol PF08996.8 T107192_3 - 1.5 8.4 4.7 11 5.6 2.4 2.5 2 1 1 3 3 3 0 DNA Polymerase alpha zinc finger DSPn PF14671.4 T363229_2 - 3.9e-54 182.8 1.9 3.9e-54 182.8 1.9 1.8 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.18 T363229_2 - 2.1e-14 53.4 0.0 4.7e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 T363229_2 - 1.4e-05 25.1 0.0 2.2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 T363229_2 - 0.00016 21.2 0.0 0.00026 20.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 T363229_2 - 0.15 11.9 0.1 0.23 11.3 0.1 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family Anth_Ig PF05587.11 T041371_3 - 5.1e-38 129.5 2.4 8.3e-38 128.9 2.4 1.3 1 0 0 1 1 1 1 Anthrax receptor extracellular domain VWA PF00092.26 T041371_3 - 1.2e-10 41.9 0.1 5.6e-10 39.6 0.2 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.4 T041371_3 - 0.054 14.0 0.0 0.22 12.0 0.0 1.9 2 0 0 2 2 2 0 von Willebrand factor type A domain ATP1G1_PLM_MAT8 PF02038.14 T068152_1 - 1.1e-18 66.1 0.4 1.7e-18 65.5 0.4 1.2 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family C1q PF00386.19 T163913_2 - 7.4e-26 90.7 0.3 1.1e-25 90.1 0.3 1.3 1 0 0 1 1 1 1 C1q domain tRNA-synt_2b PF00587.23 T123805_3 - 1.5e-35 122.6 0.0 2.3e-35 122.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.18 T123805_3 - 6e-17 61.5 0.1 1e-16 60.7 0.1 1.4 1 0 0 1 1 1 1 Anticodon binding domain TM2 PF05154.14 T123805_3 - 3.6e-13 49.5 7.9 6.8e-13 48.6 7.9 1.4 1 0 0 1 1 1 1 TM2 domain TGS PF02824.19 T123805_3 - 2.2e-11 43.5 0.0 4.2e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.12 T123805_3 - 1.2e-10 41.2 0.1 2.3e-10 40.3 0.1 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain cobW PF02492.17 T359709_3 - 5.9e-18 64.9 0.0 9e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain Peptidase_M14 PF00246.22 T361359_1 - 7.2e-13 48.8 0.0 1.1e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.12 T361359_1 - 0.0052 15.8 0.0 0.0073 15.3 0.0 1.1 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Ig_3 PF13927.4 T176601_2 - 2.3e-27 95.3 0.1 2e-14 53.8 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T176601_2 - 1.8e-22 79.3 0.0 3.8e-10 39.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T176601_2 - 1.2e-18 66.8 0.0 8.5e-11 41.6 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 T176601_2 - 2.6e-16 59.4 0.0 2.7e-08 33.7 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T176601_2 - 1.6e-14 53.8 0.2 1.8e-06 27.9 0.0 4.4 3 1 1 4 4 4 4 Immunoglobulin V-set domain C2-set_2 PF08205.10 T176601_2 - 7.3e-13 48.3 0.2 6.5e-10 38.8 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Lectin_C PF00059.19 T191501_2 - 3.7e-25 88.6 0.3 1e-24 87.2 0.3 1.8 1 0 0 1 1 1 1 Lectin C-type domain HMMR_N PF15905.3 T191501_2 - 0.0018 17.7 1.6 0.0033 16.8 1.6 1.3 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Phage_GP20 PF06810.9 T191501_2 - 0.0032 17.1 2.0 0.0054 16.4 2.0 1.3 1 0 0 1 1 1 1 Phage minor structural protein GP20 DUF812 PF05667.9 T191501_2 - 0.017 13.9 0.0 0.023 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) NPV_P10 PF05531.10 T191501_2 - 0.018 15.4 6.3 0.072 13.4 0.9 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.10 T191501_2 - 0.031 13.6 0.6 0.047 13.0 0.6 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DASH_Dad4 PF08650.8 T191501_2 - 0.064 13.1 1.5 0.19 11.6 0.3 2.3 2 1 1 3 3 3 0 DASH complex subunit Dad4 TPR_MLP1_2 PF07926.10 T191501_2 - 0.073 13.0 2.9 0.1 12.5 1.9 1.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein FPP PF05911.9 T191501_2 - 0.12 10.5 3.9 0.16 10.0 3.9 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil MAD PF05557.11 T191501_2 - 0.2 9.8 2.6 0.29 9.3 2.6 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein GAS PF13851.4 T191501_2 - 0.37 10.0 2.9 0.58 9.4 2.9 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF16 PF01519.14 T191501_2 - 0.49 10.8 5.0 7.1 7.0 1.5 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 TMF_TATA_bd PF12325.6 T191501_2 - 0.49 10.5 2.6 0.9 9.6 2.6 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding LPP PF04728.11 T191501_2 - 1 9.6 2.7 2.8 8.3 0.1 2.7 2 2 0 2 2 2 0 Lipoprotein leucine-zipper DASH_Duo1 PF08651.8 T191501_2 - 1.8 8.3 4.2 3.5 7.3 1.1 2.5 2 1 1 3 3 3 0 DASH complex subunit Duo1 ASH PF15780.3 T027328_1 - 2.8e-33 113.9 0.0 2.1e-32 111.1 0.0 2.4 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin zf-H2C2_2 PF13465.4 T027328_1 - 1.5e-31 107.3 122.4 1.9e-05 24.8 2.3 15.4 15 0 0 15 15 15 12 Zinc-finger double domain zf-C2H2 PF00096.24 T027328_1 - 2.6e-29 99.9 146.4 0.0011 19.1 1.3 15.7 15 0 0 15 15 15 11 Zinc finger, C2H2 type IQ PF00612.25 T027328_1 - 2.1e-24 82.8 79.2 0.0014 18.1 0.2 13.1 12 0 0 12 12 12 9 IQ calmodulin-binding motif BTB PF00651.29 T027328_1 - 2.5e-19 69.4 2.7 4.8e-19 68.5 0.6 2.3 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2_4 PF13894.4 T027328_1 - 4.6e-16 58.0 146.6 0.053 14.2 2.8 16.3 15 0 0 15 15 15 13 C2H2-type zinc finger CH PF00307.29 T027328_1 - 6.4e-13 48.7 5.2 5.1e-08 32.9 0.0 4.4 4 1 0 4 4 4 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 T027328_1 - 4.8e-06 26.2 0.0 1.7e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 CAMSAP CH domain zf-met PF12874.5 T027328_1 - 0.0022 18.2 0.3 0.0022 18.2 0.3 13.3 13 0 0 13 13 13 3 Zinc-finger of C2H2 type 7tm_1 PF00001.19 T309457_1 - 1.7e-29 102.8 10.7 1.7e-29 102.8 10.7 2.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) COesterase PF00135.26 T134160_1 - 2.9e-61 207.8 0.0 3.3e-60 204.3 0.0 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 T134160_1 - 0.0011 18.7 0.1 0.0019 17.9 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.26 T134160_2 - 2.4e-24 86.0 0.0 3.5e-24 85.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.26 T134160_3 - 1.2e-18 67.2 0.0 1.5e-11 43.8 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Myb_DNA-bind_7 PF15963.3 T125044_1 - 0.033 13.9 0.1 0.065 13.0 0.1 1.4 1 0 0 1 1 1 0 Myb DNA-binding like Myb_DNA-binding PF00249.29 T125044_1 - 0.12 12.4 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Jnk-SapK_ap_N PF09744.7 T125044_2 - 5.5e-56 189.0 23.9 5.5e-56 189.0 23.9 2.6 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 JIP_LZII PF16471.3 T125044_2 - 4.5e-28 97.1 9.3 4.5e-28 97.1 9.3 2.8 3 1 0 3 3 3 1 JNK-interacting protein leucine zipper II JUPITER PF17054.3 T125044_2 - 6.6e-09 35.6 0.3 9.5e-06 25.2 0.1 2.6 2 0 0 2 2 2 2 Microtubule-Associated protein Jupiter Rootletin PF15035.4 T125044_2 - 0.0013 18.7 1.7 0.0013 18.7 1.7 2.8 2 1 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion Atg14 PF10186.7 T125044_2 - 0.092 11.7 25.8 0.089 11.7 10.5 2.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ERM PF00769.17 T125044_2 - 1.4 8.5 28.5 2.4 7.8 8.3 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family KRAB PF01352.25 T171413_2 - 1.6e-23 82.0 0.2 2.4e-23 81.4 0.2 1.3 1 0 0 1 1 1 1 KRAB box Lectin_C PF00059.19 T192525_3 - 8.4e-20 71.4 0.1 1.1e-19 71.0 0.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain DcpS_C PF11969.6 T357211_1 - 6.2e-33 113.5 1.5 9.8e-33 112.9 1.5 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-C2HE PF16278.3 T357211_1 - 2.2e-13 50.3 0.0 4.8e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger HIT PF01230.21 T357211_1 - 3.8e-13 49.9 0.9 6.4e-13 49.1 0.9 1.4 1 0 0 1 1 1 1 HIT domain PINIT PF14324.4 T019428_1 - 1.8e-36 125.6 0.1 2.6e-36 125.0 0.1 1.3 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.18 T019428_1 - 7.5e-20 70.3 2.3 2e-19 69.0 2.3 1.8 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 T019428_1 - 1.9e-05 24.3 0.3 5.8e-05 22.7 0.3 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.25 T019428_1 - 0.043 13.4 0.0 0.092 12.4 0.0 1.5 1 0 0 1 1 1 0 SAP domain Histone PF00125.22 T299679_3 - 6.3e-25 88.0 0.3 9e-25 87.5 0.3 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 T299679_3 - 6.7e-06 26.2 0.0 1.3e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 T299679_3 - 0.024 15.0 0.0 0.044 14.2 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A YscO-like PF16789.3 T299679_3 - 0.048 13.6 0.1 0.07 13.0 0.1 1.1 1 0 0 1 1 1 0 YscO-like protein TPR_MLP1_2 PF07926.10 T063360_1 - 0.006 16.5 15.3 0.006 16.5 15.3 8.3 3 2 3 7 7 7 2 TPR/MLP1/MLP2-like protein Colicin PF01024.17 T063360_3 - 0.94 9.2 10.0 10 5.8 0.2 2.4 2 0 0 2 2 2 0 Colicin pore forming domain Reo_sigmaC PF04582.10 T063360_3 - 3.1 7.0 41.4 0.34 10.1 8.4 4.7 1 1 5 6 6 6 0 Reovirus sigma C capsid protein zf-C2H2 PF00096.24 T125390_3 - 3.6e-31 105.7 68.5 0.00059 20.0 0.5 10.6 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T125390_3 - 3.3e-30 103.0 76.2 5.2e-07 29.7 2.0 10.1 11 0 0 11 11 11 8 Zinc-finger double domain zf-C2H2_4 PF13894.4 T125390_3 - 3.8e-25 86.3 67.0 0.0069 17.0 0.4 10.7 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T125390_3 - 2.6e-13 49.8 20.4 0.12 12.6 0.2 9.0 8 1 1 9 9 9 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T125390_3 - 2e-08 33.8 60.3 0.005 16.6 0.1 9.8 10 0 0 10 10 10 5 C2H2-type zinc finger zf-C2HC_2 PF13913.4 T125390_3 - 0.00064 19.4 33.1 0.3 10.9 0.2 7.3 7 0 0 7 7 7 3 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.3 T125390_3 - 0.0012 18.4 35.7 0.0012 18.4 0.1 7.0 8 0 0 8 8 7 3 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 T125390_3 - 0.016 15.3 28.8 0.15 12.3 0.8 5.1 2 2 2 4 4 4 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.8 T125390_3 - 0.57 10.2 39.1 0.13 12.3 1.5 7.7 7 0 0 7 7 7 0 Zinc ribbon domain DUF4764 PF15961.3 T125390_3 - 1.9 6.9 10.9 1.7 7.1 0.1 3.2 2 2 2 4 4 4 0 Domain of unknown function (DUF4764) zinc_ribbon_15 PF17032.3 T125390_3 - 7.5 7.2 22.3 5.4 7.7 1.7 5.0 3 1 3 6 6 6 0 zinc-ribbon family ELMO_CED12 PF04727.11 T192940_1 - 5.6e-06 26.4 0.0 9.9e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family ELMO_CED12 PF04727.11 T192940_2 - 7.6e-18 65.1 0.0 1.2e-17 64.5 0.0 1.2 1 0 0 1 1 1 1 ELMO/CED-12 family HEAT PF02985.20 T353574_1 - 0.1 12.8 1.4 27 5.2 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat EF1_GNE PF00736.17 T353574_2 - 3.7e-35 119.8 0.4 5.6e-35 119.2 0.4 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 T353574_2 - 1.1e-11 44.8 7.6 1.1e-11 44.8 7.6 1.9 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region NAPRTase PF04095.14 T353574_2 - 0.0083 15.6 0.0 0.028 13.9 0.0 1.7 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) family Striatin PF08232.10 T353574_2 - 0.049 14.1 1.7 0.08 13.4 1.7 1.2 1 0 0 1 1 1 0 Striatin family JIP_LZII PF16471.3 T353574_2 - 0.21 11.6 0.5 0.36 10.9 0.5 1.3 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II Ras PF00071.20 T210542_1 - 7.1e-05 22.3 0.1 0.0001 21.8 0.1 1.2 1 0 0 1 1 1 1 Ras family Ras PF00071.20 T210542_3 - 5e-27 94.4 0.0 7.8e-27 93.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T210542_3 - 4.9e-16 58.9 0.0 8.1e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T210542_3 - 5.4e-07 29.1 0.0 8.8e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Longin PF13774.4 T240910_2 - 2.4e-07 30.6 0.4 4.4e-07 29.7 0.4 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain UL45 PF05473.10 T073845_2 - 0.059 12.9 0.1 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.19 T073845_3 - 6.3e-25 87.9 6.1 3.7e-16 59.7 1.4 2.6 2 0 0 2 2 2 2 Lectin C-type domain UL45 PF05473.10 T073845_3 - 1.4e-08 34.5 8.3 0.0018 17.8 0.1 2.5 2 1 0 2 2 2 2 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 T073845_3 - 1.5e-05 24.2 2.2 0.037 13.2 0.3 2.3 2 0 0 2 2 2 2 Chordopoxvirus A33R protein FAM117 PF15388.4 T150143_1 - 6.1e-111 370.5 1.9 8.4e-111 370.1 1.9 1.2 1 0 0 1 1 1 1 Protein Family FAM117 UAA PF08449.9 T150143_2 - 1.4e-41 142.5 16.8 3e-41 141.4 16.8 1.5 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.14 T150143_2 - 5.3e-10 39.0 8.7 4.8e-09 35.9 8.7 2.0 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 T150143_2 - 4.7e-08 33.1 24.7 4.2e-07 30.1 12.1 2.9 2 1 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.8 T150143_2 - 0.0097 14.8 0.3 0.0097 14.8 0.3 2.2 1 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like Spin-Ssty PF02513.15 T375513_2 - 6.6e-64 211.3 14.7 5e-23 80.5 0.5 4.0 4 0 0 4 4 4 3 Spin/Ssty Family Calx-beta PF03160.12 T188127_1 - 4.8e-60 199.8 8.5 7.7e-35 118.9 2.1 2.4 2 0 0 2 2 2 2 Calx-beta domain Na_Ca_ex PF01699.22 T188127_1 - 2.7e-58 196.1 41.7 7e-35 120.1 11.3 3.0 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.3 T188127_1 - 1.3e-50 171.0 5.8 2e-50 170.4 5.8 1.3 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain DnaG_DnaB_bind PF08278.9 T188127_1 - 0.26 11.8 2.2 0.48 10.9 2.2 1.3 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding Metallothio_11 PF02066.13 T188127_1 - 0.84 9.7 7.3 2.1 8.5 7.3 1.7 1 0 0 1 1 1 0 Metallothionein family 11 Sema PF01403.17 T116234_3 - 3.4e-131 437.8 0.0 7.3e-131 436.7 0.0 1.4 1 0 0 1 1 1 1 Sema domain PRT_C PF08372.8 T116234_3 - 0.31 10.7 1.8 0.81 9.3 1.8 1.7 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal p450 PF00067.20 T191708_1 - 6.8e-57 193.1 0.0 8.3e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CLN5 PF15014.4 T096431_1 - 2.3e-170 565.9 6.6 3e-170 565.5 6.6 1.1 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 5 SH3_1 PF00018.26 T167144_1 - 1.2e-25 88.7 2.6 3.6e-16 58.4 0.2 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.15 T167144_1 - 9.9e-23 79.5 0.5 1.8e-13 49.8 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.4 T167144_1 - 7e-19 67.3 0.6 1.1e-12 47.4 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.22 T167144_1 - 1.8e-17 63.0 0.0 4.8e-17 61.7 0.0 1.8 1 0 0 1 1 1 1 SH2 domain RhoGEF PF00621.18 T167144_1 - 4.3e-16 59.6 0.7 2e-15 57.4 0.1 2.3 2 1 0 2 2 2 1 RhoGEF domain C1_1 PF00130.20 T167144_1 - 1.1e-10 41.1 6.4 1.1e-10 41.1 6.4 2.3 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 T167144_1 - 3.5e-09 37.0 0.2 6.4e-09 36.1 0.2 1.4 1 0 0 1 1 1 1 PH domain C1_2 PF03107.14 T167144_1 - 0.00049 20.2 4.3 0.0014 18.7 4.3 1.9 1 0 0 1 1 1 1 C1 domain DUF3104 PF11302.6 T167144_1 - 0.029 14.0 0.3 3.5 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3104) CAMSAP_CH PF11971.6 T167144_3 - 2.8e-21 75.0 0.1 4.2e-21 74.5 0.1 1.3 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.29 T167144_3 - 2.5e-20 72.5 0.1 3.6e-20 72.0 0.1 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain RhoGEF PF00621.18 T167144_3 - 1.9e-07 31.4 0.1 2.8e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 RhoGEF domain CDC24 PF06395.9 T167144_3 - 0.00011 22.3 0.1 0.00018 21.6 0.1 1.3 1 0 0 1 1 1 1 CDC24 Calponin Methyltransf_32 PF13679.4 T022631_1 - 3.1e-30 105.1 0.1 4.3e-30 104.7 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T022631_1 - 0.073 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TRM13 PF05206.12 T022631_1 - 0.078 12.4 0.0 5.7 6.2 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase TRM13 RrnaAD PF00398.18 T022631_1 - 0.12 11.3 0.1 0.19 10.6 0.1 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase zf-C2H2 PF00096.24 T150045_3 - 2.7e-28 96.7 61.7 9.9e-05 22.5 1.5 10.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T150045_3 - 4.2e-19 67.9 73.5 9.7e-07 28.8 1.3 10.7 10 0 0 10 10 10 6 Zinc-finger double domain zf-C2H2_4 PF13894.4 T150045_3 - 1e-15 56.9 74.7 0.00081 19.9 0.8 11.8 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T150045_3 - 5.5e-05 23.2 38.3 0.48 10.7 0.0 8.1 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T150045_3 - 0.011 16.0 0.3 0.011 16.0 0.3 9.5 9 0 0 9 9 9 0 Zinc-finger of C2H2 type BSP_II PF05432.9 T150045_3 - 0.25 10.9 18.9 0.38 10.3 18.9 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF3268 PF11672.6 T150045_3 - 3.9 7.7 12.3 13 6.0 0.3 3.6 3 0 0 3 3 3 0 zinc-finger-containing domain zf-C2H2 PF00096.24 T174611_3 - 1.4e-68 223.6 118.1 4e-06 26.8 1.7 16.2 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T174611_3 - 1.3e-60 199.2 92.5 1.3e-07 31.6 0.7 16.4 16 0 0 16 16 16 12 Zinc-finger double domain zf-C2H2_4 PF13894.4 T174611_3 - 3.1e-36 120.8 125.8 0.0016 18.9 0.9 16.9 17 0 0 17 17 15 13 C2H2-type zinc finger KRAB PF01352.25 T174611_3 - 9.7e-23 79.4 0.4 2.6e-22 78.1 0.4 1.8 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 T174611_3 - 2.4e-07 30.6 53.3 0.089 12.8 0.4 8.7 3 2 6 10 10 10 8 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T174611_3 - 1.2e-05 25.3 37.0 0.18 12.0 0.0 10.5 12 0 0 12 12 12 3 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 T174611_3 - 1.6e-05 24.6 47.9 0.25 11.1 0.1 12.7 13 0 0 13 13 13 3 Probable zinc-ribbon domain DUF3268 PF11672.6 T174611_3 - 1.9e-05 24.9 36.0 0.19 11.9 0.8 7.1 5 2 1 7 7 7 4 zinc-finger-containing domain zf-C2H2_6 PF13912.4 T174611_3 - 0.00029 20.6 91.7 0.5 10.2 0.3 14.0 13 1 1 14 14 14 9 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T174611_3 - 0.0003 21.3 37.9 3.1 8.5 0.6 6.9 1 1 5 6 6 6 2 zinc-ribbon family ADK_lid PF05191.12 T174611_3 - 0.00063 19.6 43.6 0.62 10.0 0.7 9.1 4 1 5 9 9 9 4 Adenylate kinase, active site lid zf-C2H2_11 PF16622.3 T174611_3 - 0.025 14.2 98.5 0.052 13.2 1.9 15.5 16 0 0 16 16 16 0 zinc-finger C2H2-type HTH_18 PF12833.5 T174611_3 - 0.04 14.0 1.5 8.1 6.7 0.1 4.1 3 1 0 3 3 3 0 Helix-turn-helix domain DZR PF12773.5 T174611_3 - 0.15 12.0 50.0 1.6e+04 -34.5 50.0 7.6 1 1 0 1 1 0 0 Double zinc ribbon Spt4 PF06093.11 T151431_1 - 6.1e-24 83.8 0.1 1.4e-23 82.7 0.1 1.6 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger zf-RING_2 PF13639.4 T151431_3 - 2.3e-11 43.6 8.6 2.3e-11 43.6 8.6 3.2 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.4 T151431_3 - 5.5e-09 35.6 7.0 2e-08 33.8 7.0 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 T151431_3 - 1.7e-08 33.9 3.6 1.7e-08 33.9 3.6 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.23 T151431_3 - 1.7e-07 30.8 6.7 8e-07 28.7 6.7 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 T151431_3 - 1.6e-05 25.0 8.7 1.6e-05 25.0 8.7 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 T151431_3 - 0.0014 18.4 6.0 0.0014 18.4 6.0 2.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3H2C3 PF17122.3 T151431_3 - 0.37 10.8 4.4 1.4 8.8 4.4 2.1 1 0 0 1 1 1 0 Zinc-finger DUF1041 PF06292.15 T244411_2 - 1.2e-35 121.9 0.9 2.8e-35 120.7 0.9 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) PH PF00169.27 T244411_2 - 7.1e-08 32.8 0.0 1.5e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 PH domain Sporozoite_P67 PF05642.9 T244411_2 - 0.8 7.6 11.7 1.5 6.6 11.7 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Fibrinogen_C PF00147.16 T339722_2 - 9.7e-79 264.1 16.4 1.3e-78 263.6 16.4 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain HERV-K_REC PF15695.3 T339722_2 - 0.028 14.3 3.3 0.068 13.1 3.3 1.5 1 0 0 1 1 1 0 Rec (regulator of expression encoded by corf) of HERV-K-113 Pkinase PF00069.23 T236312_2 - 1.3e-58 198.4 0.0 1.2e-32 113.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Spc97_Spc98 PF04130.11 T236312_2 - 2.3e-41 142.1 0.2 3.2e-41 141.6 0.2 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Pkinase_Tyr PF07714.15 T236312_2 - 1.3e-20 73.6 0.0 7.1e-10 38.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Hist_deacetyl PF00850.17 T236312_2 - 3.9e-07 29.7 0.1 9.5e-07 28.5 0.0 1.7 2 0 0 2 2 2 1 Histone deacetylase domain Spc97_Spc98 PF04130.11 T236312_3 - 1.3e-48 166.0 0.9 1.8e-48 165.6 0.9 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Hist_deacetyl PF00850.17 T236312_3 - 1.4e-46 159.3 0.1 2.2e-46 158.6 0.1 1.1 1 0 0 1 1 1 1 Histone deacetylase domain DUF3338 PF11819.6 T374540_1 - 7.9e-39 132.6 5.1 1.4e-38 131.8 5.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) HR1 PF02185.14 T374540_1 - 7.5 6.6 7.9 17 5.5 7.9 1.6 1 0 0 1 1 1 0 Hr1 repeat SH2 PF00017.22 T045097_3 - 1.8e-10 40.6 0.0 3.3e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 SH2 domain EMI PF07546.11 T301370_1 - 7.9e-17 61.6 10.2 1.9e-16 60.4 10.2 1.7 1 0 0 1 1 1 1 EMI domain Palm_thioest PF02089.13 T301370_1 - 2.1e-11 43.4 0.0 3.3e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase EGF PF00008.25 T301370_1 - 1.5e-06 28.2 20.0 0.00047 20.3 7.0 3.1 2 0 0 2 2 2 2 EGF-like domain EGF_CA PF07645.13 T301370_1 - 3.7e-06 26.9 5.0 3.7e-06 26.9 5.0 3.5 3 0 0 3 3 3 1 Calcium-binding EGF domain Abhydrolase_1 PF00561.18 T301370_1 - 5.7e-06 26.0 0.0 3e-05 23.7 0.1 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold FXa_inhibition PF14670.4 T301370_1 - 1.3e-05 25.3 7.4 1.3e-05 25.3 7.4 3.8 4 0 0 4 4 4 1 Coagulation Factor Xa inhibitory site DUF676 PF05057.12 T301370_1 - 0.0063 15.9 0.0 0.013 14.9 0.0 1.4 1 1 0 1 1 1 1 Putative serine esterase (DUF676) hEGF PF12661.5 T301370_1 - 0.01 16.4 5.6 0.01 16.4 5.6 3.4 2 0 0 2 2 2 0 Human growth factor-like EGF PGAP1 PF07819.11 T301370_1 - 0.057 13.0 0.0 0.12 11.9 0.0 1.4 2 0 0 2 2 2 0 PGAP1-like protein Rhomboid PF01694.20 T124355_1 - 4.2e-34 117.5 8.4 6.9e-34 116.9 8.4 1.3 1 0 0 1 1 1 1 Rhomboid family EF_assoc_2 PF08356.10 T124355_1 - 1.7e-22 79.1 0.0 2.8e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.10 T124355_1 - 2e-21 75.2 0.0 4.3e-21 74.2 0.0 1.6 1 0 0 1 1 1 1 EF hand associated WD40 PF00400.30 T124355_1 - 1.6e-09 38.1 2.7 0.1 13.4 0.0 6.3 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T124355_1 - 0.00079 19.5 0.0 2.8 8.2 0.0 3.9 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_6 PF13405.4 T124355_1 - 0.0062 16.3 0.0 0.021 14.6 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.4 T124355_1 - 0.009 16.3 0.0 0.47 10.8 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 T124355_1 - 0.013 14.9 0.0 0.11 12.0 0.0 2.4 3 0 0 3 3 3 0 EF hand Ras PF00071.20 T124355_1 - 0.099 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Ras family DUF667 PF05018.11 T124355_2 - 3.1e-31 108.4 0.0 8.1e-31 107.0 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF667) WD40 PF00400.30 T124355_2 - 2.5e-13 50.1 14.9 0.32 11.8 0.0 9.5 8 1 0 8 8 8 5 WD domain, G-beta repeat Ras PF00071.20 T124355_2 - 1.2e-07 31.3 0.0 0.0037 16.8 0.0 2.3 1 1 1 2 2 2 2 Ras family Roc PF08477.11 T124355_2 - 0.00046 20.3 0.0 0.033 14.3 0.0 3.4 3 1 1 4 4 4 1 Ras of Complex, Roc, domain of DAPkinase Nup160 PF11715.6 T124355_2 - 0.0025 16.4 0.0 0.0044 15.6 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 FAM195 PF14799.4 T124355_3 - 3.8e-27 94.5 0.0 6.1e-27 93.8 0.0 1.3 1 0 0 1 1 1 1 FAM195 family WD40 PF00400.30 T124355_3 - 0.00015 22.3 1.4 29 5.6 0.0 4.9 4 0 0 4 4 4 2 WD domain, G-beta repeat HELP PF03451.12 T124355_3 - 0.14 11.9 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 HELP motif DOR PF14839.4 T347980_3 - 1.5e-84 283.7 6.7 2.1e-84 283.3 6.7 1.2 1 0 0 1 1 1 1 DOR family PAS_11 PF14598.4 T186185_3 - 4e-38 129.9 0.0 3.1e-34 117.4 0.0 2.5 2 0 0 2 2 2 2 PAS domain NCOA_u2 PF16665.3 T186185_3 - 5e-29 100.9 19.2 5e-29 100.9 19.2 5.1 4 1 1 5 5 5 1 Unstructured region on nuclear receptor coactivator protein DUF1518 PF07469.10 T186185_3 - 1.8e-27 95.3 37.9 2.3e-15 56.6 14.6 6.9 8 1 0 8 8 8 2 Domain of unknown function (DUF1518) SRC-1 PF08832.8 T186185_3 - 5.1e-23 81.8 6.1 5.1e-23 81.8 6.1 3.2 3 0 0 3 3 3 1 Steroid receptor coactivator Nuc_rec_co-act PF08815.8 T186185_3 - 3.4e-20 71.5 1.5 3.4e-20 71.5 1.5 2.3 2 0 0 2 2 2 1 Nuclear receptor coactivator PAS PF00989.23 T186185_3 - 1.8e-07 31.0 0.0 6.5e-07 29.2 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.10 T186185_3 - 4.7e-07 29.9 0.0 0.00088 19.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold DUF4927 PF16279.3 T186185_3 - 8.2e-06 26.6 7.1 8.2e-06 26.6 7.1 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4927) PAS_9 PF13426.5 T186185_3 - 5.1e-05 23.3 0.0 0.00057 20.0 0.0 2.5 2 0 0 2 2 2 1 PAS domain HLH PF00010.24 T186185_3 - 0.00022 21.0 1.0 0.0005 19.8 1.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RGS PF00615.17 T152755_1 - 1.8e-27 95.8 1.4 3.1e-27 95.1 1.4 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain DIX PF00778.15 T152755_1 - 4.2e-27 93.7 0.0 7.5e-27 92.9 0.0 1.4 1 0 0 1 1 1 1 DIX domain AXIN1_TNKS_BD PF16646.3 T152755_1 - 6.6e-23 81.2 10.5 1.9e-22 79.8 10.5 1.9 1 0 0 1 1 1 1 Axin-1 tankyrase binding domain Axin_b-cat_bind PF08833.8 T152755_1 - 2.6e-09 36.9 0.3 2.6e-09 36.9 0.3 2.2 2 0 0 2 2 2 1 Axin beta-catenin binding domain HLH PF00010.24 T368904_3 - 0.00019 21.2 0.4 0.00045 20.0 0.4 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RA PF00788.21 T315638_2 - 5.7e-46 155.0 0.0 7.1e-23 80.9 0.0 2.8 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain DIL PF01843.17 T315638_2 - 8.1e-31 106.3 2.1 1.2e-30 105.7 0.6 2.1 2 0 0 2 2 2 1 DIL domain PDZ PF00595.22 T315638_2 - 1.8e-16 60.1 0.5 1.8e-16 60.1 0.5 1.9 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) FHA PF00498.24 T315638_2 - 6.4e-07 29.5 0.0 1.4e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 FHA domain PDZ_2 PF13180.4 T315638_2 - 0.0021 18.2 0.4 0.0058 16.8 0.4 1.7 1 0 0 1 1 1 1 PDZ domain Yop-YscD_cpl PF16697.3 T315638_2 - 0.0078 16.4 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Sushi PF00084.18 T029340_2 - 8.7e-30 103.0 19.9 2.4e-10 40.8 0.7 5.1 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) SCAN PF02023.15 T115457_1 - 1.5e-42 143.2 3.0 3.5e-42 142.0 3.0 1.7 1 0 0 1 1 1 1 SCAN domain Myb_DNA-bind_4 PF13837.4 T115457_1 - 5.5e-40 135.5 0.1 9.2e-19 67.5 0.0 2.5 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain zf-H2C2_2 PF13465.4 T115457_1 - 1.8e-38 129.1 45.7 5.2e-08 32.9 0.2 7.1 7 0 0 7 7 6 6 Zinc-finger double domain zf-C2H2 PF00096.24 T115457_1 - 2e-34 116.0 48.9 5.5e-06 26.4 1.5 7.0 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T115457_1 - 3e-14 52.3 48.4 0.01 16.5 2.7 7.7 7 0 0 7 7 6 5 C2H2-type zinc finger MADF_DNA_bdg PF10545.7 T115457_1 - 1.1e-05 25.5 0.3 0.097 12.9 0.1 2.7 2 0 0 2 2 2 2 Alcohol dehydrogenase transcription factor Myb/SANT-like zf-C2H2_11 PF16622.3 T115457_1 - 0.00035 20.1 32.8 0.086 12.5 1.1 6.6 7 0 0 7 7 7 3 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T115457_1 - 0.0028 17.6 2.5 0.0028 17.6 2.5 5.8 5 1 2 7 7 7 3 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T115457_1 - 0.016 15.8 17.9 0.45 11.2 3.6 3.8 2 1 1 3 3 3 0 zinc-ribbon family zf-C2H2_6 PF13912.4 T115457_1 - 0.031 14.1 36.7 0.031 14.1 1.4 6.6 6 0 0 6 6 6 0 C2H2-type zinc finger PPP4R2 PF09184.9 T115457_1 - 0.04 13.4 1.6 0.082 12.3 1.6 1.4 1 0 0 1 1 1 0 PPP4R2 Myb_DNA-bind_6 PF13921.4 T115457_1 - 0.12 12.5 0.2 8.8 6.5 0.0 2.6 2 0 0 2 2 2 0 Myb-like DNA-binding domain DZR PF12773.5 T115457_1 - 0.22 11.4 22.7 4.5 7.2 5.3 4.1 1 1 1 2 2 2 0 Double zinc ribbon zf-C2H2_jaz PF12171.6 T115457_1 - 0.31 11.3 26.6 0.69 10.2 0.5 5.6 6 0 0 6 6 5 0 Zinc-finger double-stranded RNA-binding OSTMP1 PF09777.7 T115457_1 - 0.5 9.6 12.4 9.1 5.5 5.8 3.1 3 0 0 3 3 3 0 Osteopetrosis-associated transmembrane protein 1 precursor zf-LYAR PF08790.9 T115457_1 - 1.2 9.0 28.7 0.71 9.7 0.4 6.3 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger DUF3268 PF11672.6 T115457_1 - 8.4 6.6 13.4 14 5.9 1.6 3.6 3 0 0 3 3 3 0 zinc-finger-containing domain TORC_M PF12885.5 T170753_1 - 2e-67 226.0 7.7 2e-67 226.0 7.7 2.2 2 1 0 2 2 2 1 Transducer of regulated CREB activity middle domain TORC_C PF12886.5 T170753_1 - 2.8e-32 111.0 2.2 4.8e-32 110.2 2.2 1.4 1 0 0 1 1 1 1 Transducer of regulated CREB activity, C terminus TORC_N PF12884.5 T170753_1 - 1.8e-23 82.9 0.0 4.7e-23 81.6 0.0 1.8 1 0 0 1 1 1 1 Transducer of regulated CREB activity, N terminus MAP7 PF05672.9 T008004_2 - 1.2e-37 129.0 78.2 1.2e-37 129.0 78.2 4.3 4 0 0 4 4 4 1 MAP7 (E-MAP-115) family NTR PF01759.19 T165677_1 - 9.5e-10 38.1 0.0 1.6e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 UNC-6/NTR/C345C module ADAM_spacer1 PF05986.12 T165677_3 - 1.2e-26 92.9 0.0 1.7e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.17 T165677_3 - 5.8e-07 29.5 9.0 5.8e-07 29.5 9.0 3.5 4 0 0 4 4 4 1 Thrombospondin type 1 domain Ribosomal_L23 PF00276.18 T052965_2 - 1.8e-11 44.1 0.0 2.9e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L23 CTF_NFI PF00859.16 T166280_1 - 3.5e-105 352.0 16.7 7.1e-105 351.0 16.7 1.5 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.7 T166280_1 - 8.6e-27 92.7 2.9 1.5e-26 91.9 2.9 1.4 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.14 T166280_1 - 4.3e-10 39.6 0.1 9e-10 38.6 0.1 1.5 1 0 0 1 1 1 1 MH1 domain Mit_proteolip PF08039.9 T166280_2 - 1.3 9.3 5.5 3.1 8.1 5.5 1.5 1 0 0 1 1 1 0 Mitochondrial proteolipid DUF3996 PF13161.4 T182102_1 - 0.012 15.2 0.3 15 5.2 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3996) zf-H2C2_2 PF13465.4 T182102_3 - 1.7e-86 280.9 99.3 4.3e-08 33.1 0.7 15.0 15 0 0 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 T182102_3 - 3.5e-58 190.8 120.3 1.4e-05 25.1 0.6 16.1 17 0 0 17 17 17 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T182102_3 - 1.3e-38 128.1 110.2 0.0011 19.5 1.0 15.9 15 0 0 15 15 15 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T182102_3 - 1.4e-26 91.7 91.2 0.01 15.6 1.2 13.9 13 0 0 13 13 13 13 C2H2-type zinc finger KRAB PF01352.25 T182102_3 - 1.9e-21 75.3 1.3 3.7e-21 74.4 1.3 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 T182102_3 - 5.6e-05 23.2 50.3 8.8 6.6 0.0 13.4 14 0 0 14 14 14 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T182102_3 - 0.00017 21.5 75.0 0.18 11.8 3.4 8.9 3 2 9 12 12 12 9 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T182102_3 - 0.00047 20.7 48.7 0.21 12.2 1.0 7.1 1 1 7 8 8 8 3 zinc-ribbon family XPA_N PF01286.16 T182102_3 - 2.1 8.3 66.2 9.7 6.2 0.2 13.0 13 0 0 13 13 13 0 XPA protein N-terminal UCH PF00443.27 T303596_1 - 1.6e-33 116.2 0.9 2.3e-33 115.6 0.9 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 T303596_1 - 8.4e-20 70.7 8.4 3.3e-19 68.8 8.4 2.1 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 T303596_1 - 2.4e-09 37.2 2.3 2.4e-05 24.0 0.3 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Med20 PF08612.9 T303596_2 - 1.1e-46 158.9 0.0 1.5e-46 158.5 0.0 1.2 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex TFIIS_M PF07500.12 T222112_1 - 3.9e-26 91.5 1.8 7e-26 90.7 1.8 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.11 T222112_1 - 2.5e-24 85.8 0.0 6.7e-24 84.4 0.0 1.7 2 0 0 2 2 2 1 SPOC domain PHD PF00628.27 T222112_1 - 8.4e-11 41.5 8.0 2.1e-10 40.2 8.0 1.8 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.4 T222112_1 - 2.4 7.6 8.1 0.59 9.6 3.9 1.9 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain MFS_2 PF13347.4 T047841_1 - 6.2e-19 67.7 10.3 7.2e-11 41.1 0.5 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein GPCR_chapero_1 PF11904.6 T061942_3 - 4e-66 223.4 0.0 7.1e-66 222.6 0.0 1.4 1 0 0 1 1 1 1 GPCR-chaperone DSPc PF00782.18 T061942_3 - 3.6e-29 101.1 0.0 5.2e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.9 T061942_3 - 9.2e-12 44.6 0.1 1.5e-11 43.9 0.1 1.3 1 0 0 1 1 1 1 DEK C terminal domain Y_phosphatase PF00102.25 T061942_3 - 0.0048 16.4 0.0 0.0079 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PX PF00787.22 T320402_2 - 1e-23 83.4 1.9 1.6e-23 82.7 1.9 1.3 1 0 0 1 1 1 1 PX domain SNF PF00209.16 T241521_3 - 1.1e-168 562.1 29.9 1.5e-168 561.7 29.9 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Laminin_G_2 PF02210.22 T136379_2 - 3.3e-87 289.3 2.7 1.4e-24 86.9 0.1 4.3 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.21 T136379_2 - 2.6e-55 186.1 0.0 1.3e-15 57.6 0.0 4.3 4 0 0 4 4 4 4 Laminin G domain F5_F8_type_C PF00754.23 T136379_2 - 2.9e-27 95.2 0.2 2.9e-27 95.2 0.2 1.8 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_3 PF13385.4 T136379_2 - 1e-11 45.1 0.0 0.00052 20.1 0.0 3.7 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 T136379_2 - 8.2e-05 22.7 36.1 0.0012 18.9 9.6 4.2 3 0 0 3 3 3 2 EGF-like domain COLFI PF01410.16 T136379_2 - 0.0065 15.7 0.4 0.061 12.5 0.4 2.3 1 1 0 1 1 1 1 Fibrillar collagen C-terminal domain TMC PF07810.11 T180698_1 - 4.4e-41 139.8 1.1 7.5e-41 139.1 1.1 1.4 1 0 0 1 1 1 1 TMC domain Cir_N PF10197.7 T180698_1 - 3.8e-06 26.8 8.1 3.8e-06 26.8 8.1 3.6 3 0 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR MBOAT PF03062.17 T180698_2 - 1.3e-08 34.5 2.9 2e-08 33.9 2.9 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT PF03062.17 T180698_3 - 3.2e-17 62.8 4.3 4.9e-17 62.2 4.3 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family fn2 PF00040.17 T259840_1 - 2.6e-16 59.5 3.8 2.6e-16 59.5 3.8 2.9 3 0 0 3 3 3 1 Fibronectin type II domain EGF PF00008.25 T259840_1 - 2.7e-09 37.0 25.2 6.6e-06 26.2 3.4 4.0 3 0 0 3 3 3 2 EGF-like domain Kringle PF00051.16 T259840_1 - 6e-09 36.0 0.4 9.1e-08 32.2 0.0 3.0 2 0 0 2 2 2 1 Kringle domain fn1 PF00039.16 T259840_1 - 4.6e-05 23.4 8.0 0.00014 21.9 8.0 1.9 1 0 0 1 1 1 1 Fibronectin type I domain hEGF PF12661.5 T259840_1 - 8.1e-05 23.0 16.3 0.0087 16.6 4.0 4.1 2 0 0 2 2 2 2 Human growth factor-like EGF EGF_2 PF07974.11 T259840_1 - 1.2 9.4 34.4 0.066 13.5 3.5 5.1 4 0 0 4 4 4 0 EGF-like domain cEGF PF12662.5 T259840_1 - 5.7 6.8 10.3 13 5.7 1.4 3.4 2 0 0 2 2 2 0 Complement Clr-like EGF-like RGS12_usC PF16612.3 T259840_2 - 6.4e-56 188.6 15.2 6.4e-56 188.6 15.2 2.7 2 0 0 2 2 2 1 C-terminal unstructured region of RGS12 RGS12_us1 PF16613.3 T259840_2 - 2.6e-41 140.5 9.2 2.6e-41 140.5 9.2 2.5 2 0 0 2 2 2 1 Unstructured region of RGS12 RGS PF00615.17 T259840_2 - 5.5e-27 94.2 2.7 8.2e-27 93.7 2.7 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain PDZ PF00595.22 T259840_2 - 1.1e-12 48.0 0.8 2.7e-12 46.7 0.0 2.0 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) Kringle PF00051.16 T259840_2 - 2.4e-08 34.0 1.3 5.9e-08 32.8 1.3 1.6 1 0 0 1 1 1 1 Kringle domain GoLoco PF02188.15 T259840_2 - 8.2e-08 31.5 0.2 2e-07 30.3 0.2 1.7 1 0 0 1 1 1 1 GoLoco motif PID PF00640.21 T259840_2 - 0.0015 18.4 0.0 0.0028 17.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ_2 PF13180.4 T259840_2 - 0.0072 16.5 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PT-HINT PF07591.9 T259840_2 - 0.15 12.1 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Pretoxin HINT domain Trypsin PF00089.24 T259840_3 - 3.5e-67 226.3 0.1 6e-67 225.6 0.1 1.4 1 0 0 1 1 1 1 Trypsin RBD PF02196.13 T259840_3 - 4.5e-32 109.8 0.0 6.5e-19 67.7 0.0 2.5 2 0 0 2 2 2 2 Raf-like Ras-binding domain RGS12_us1 PF16613.3 T259840_3 - 9.9e-12 45.1 0.8 2.4e-11 43.8 0.8 1.7 1 0 0 1 1 1 1 Unstructured region of RGS12 RGS12_us2 PF16611.3 T259840_3 - 6.4e-07 29.6 2.3 1.5e-06 28.4 2.3 1.6 1 0 0 1 1 1 1 Unstructured region between RBD and GoLoco DUF1986 PF09342.9 T259840_3 - 0.00063 20.0 0.0 0.001 19.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) TUG-UBL1 PF11470.6 T259840_3 - 0.033 14.3 0.0 0.64 10.2 0.0 2.3 2 0 0 2 2 2 0 TUG ubiquitin-like domain EGF_CA PF07645.13 T235214_1 - 8.2e-65 214.6 128.8 3.2e-10 39.9 8.2 10.8 10 1 0 10 10 10 8 Calcium-binding EGF domain cEGF PF12662.5 T235214_1 - 1.7e-56 187.5 63.5 1.1e-10 41.0 1.6 9.9 9 0 0 9 9 9 8 Complement Clr-like EGF-like EGF_3 PF12947.5 T235214_1 - 2.4e-13 49.9 95.7 9.7e-05 22.4 3.5 10.9 10 0 0 10 10 10 8 EGF domain FXa_inhibition PF14670.4 T235214_1 - 3.3e-10 39.9 55.5 4.1e-06 26.8 6.0 11.3 13 0 0 13 13 13 6 Coagulation Factor Xa inhibitory site ANATO PF01821.16 T235214_1 - 0.002 18.8 9.1 0.002 18.8 9.1 8.0 8 0 0 8 8 8 2 Anaphylotoxin-like domain EGF PF00008.25 T235214_1 - 0.0032 17.6 7.6 0.0032 17.6 7.6 11.6 10 0 0 10 10 10 7 EGF-like domain Y_phosphatase PF00102.25 T158284_1 - 1e-149 496.4 0.2 1.1e-83 280.3 0.1 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase MAM PF00629.21 T158284_1 - 3.9e-32 111.2 0.0 1e-31 109.9 0.0 1.8 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu fn3 PF00041.19 T158284_1 - 2.3e-26 91.8 8.2 1.5e-09 38.0 0.0 5.3 5 0 0 5 5 5 3 Fibronectin type III domain ig PF00047.23 T158284_1 - 2.6e-12 46.6 0.0 1.3e-11 44.4 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain DSPc PF00782.18 T158284_1 - 3.3e-08 33.3 0.1 0.0049 16.5 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain I-set PF07679.14 T158284_1 - 0.00013 21.9 0.0 0.00032 20.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Y_phosphatase3 PF13350.4 T158284_1 - 0.00016 21.6 0.0 0.017 14.9 0.0 2.4 2 0 0 2 2 2 1 Tyrosine phosphatase family Ig_3 PF13927.4 T158284_1 - 0.00025 21.4 0.0 0.0013 19.2 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain PTPlike_phytase PF14566.4 T158284_1 - 0.00051 20.1 0.0 0.13 12.3 0.0 2.6 2 0 0 2 2 2 1 Inositol hexakisphosphate Pur_ac_phosph_N PF16656.3 T158284_1 - 0.001 19.5 1.1 0.36 11.3 0.1 3.7 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain ECSCR PF15820.3 T158284_1 - 0.0034 17.0 0.1 0.0074 16.0 0.1 1.5 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator Ig_2 PF13895.4 T158284_1 - 0.011 15.9 1.2 0.049 13.9 0.0 2.6 3 0 0 3 3 3 0 Immunoglobulin domain EphA2_TM PF14575.4 T158284_1 - 0.058 14.1 0.2 0.21 12.3 0.1 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DctM PF06808.10 T158284_1 - 0.077 11.7 0.1 0.12 11.1 0.1 1.1 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporter, DctM component DUF948 PF06103.9 T158284_1 - 0.12 12.6 0.1 0.32 11.1 0.1 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Peptidase_C2 PF00648.19 T187255_2 - 3.7e-101 337.9 0.3 4.8e-101 337.5 0.3 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 T187255_2 - 8.5e-09 35.7 0.2 2.3e-08 34.3 0.2 1.6 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_8 PF13833.4 T187255_2 - 0.0029 17.2 0.0 0.0058 16.3 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair GKAP PF03359.11 T337610_1 - 8.5e-63 212.9 0.3 8.5e-63 212.9 0.3 2.8 3 0 0 3 3 3 1 Guanylate-kinase-associated protein (GKAP) protein CH PF00307.29 T234949_1 - 1.2e-25 89.7 3.7 1.4e-12 47.7 0.1 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 T234949_1 - 0.00036 20.2 0.2 0.082 12.6 0.1 2.4 2 0 0 2 2 2 2 CAMSAP CH domain CH PF00307.29 T234949_3 - 2.1e-30 105.0 3.5 6.9e-16 58.3 0.7 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain C2 PF00168.28 T306469_3 - 4.1e-38 129.7 0.0 1.9e-18 66.5 0.1 2.6 2 0 0 2 2 2 2 C2 domain PDZ PF00595.22 T306469_3 - 8.3e-10 38.7 0.0 1.6e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) WD40 PF00400.30 T254088_1 - 8.9e-14 51.6 1.1 0.0011 19.6 0.0 4.9 4 0 0 4 4 4 4 WD domain, G-beta repeat Serpin PF00079.18 T254088_2 - 1.4e-110 369.9 7.7 1.9e-110 369.6 7.7 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) WD40 PF00400.30 T254088_2 - 0.033 14.9 0.6 2.1 9.2 0.0 3.1 3 0 0 3 3 3 0 WD domain, G-beta repeat GRIN_C PF15235.4 T041205_3 - 1e-24 87.1 0.0 2.3e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 G protein-regulated inducer of neurite outgrowth C-terminus TPR_1 PF00515.26 T185586_2 - 2.3e-17 61.9 4.4 1.3e-07 31.0 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 T185586_2 - 5.8e-14 50.9 4.6 1.4e-07 30.9 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.4 T185586_2 - 1.4e-10 40.4 1.1 0.00034 20.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.4 T185586_2 - 2.5e-08 33.9 1.5 0.0087 16.7 0.4 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 T185586_2 - 8.8e-07 28.4 4.8 0.00024 20.6 0.0 4.0 3 1 1 4 4 4 2 TPR repeat TPR_12 PF13424.4 T185586_2 - 4.9e-06 26.6 0.3 0.61 10.3 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 T185586_2 - 6.3e-06 26.7 4.5 0.047 14.3 2.0 2.5 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 T185586_2 - 4.3e-05 23.5 0.6 0.00033 20.6 0.0 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.4 T185586_2 - 5.3e-05 23.2 1.7 0.12 12.6 0.0 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_4 PF07721.12 T185586_2 - 8.8e-05 22.6 0.1 0.056 14.0 0.1 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_10 PF13374.4 T185586_2 - 0.00012 21.6 4.0 0.75 9.6 0.4 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 T185586_2 - 0.00014 22.2 3.8 0.14 12.5 0.7 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.4 T185586_2 - 0.00021 21.0 2.2 0.86 9.7 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF1936 PF09151.8 T185586_2 - 0.042 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1936) Fis1_TPR_C PF14853.4 T185586_2 - 0.042 13.8 2.1 0.51 10.3 0.1 2.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.5 T185586_2 - 0.05 13.7 2.0 0.38 10.9 1.3 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 T185586_2 - 0.09 13.3 2.8 11 6.7 0.1 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat zf-H2C2_2 PF13465.4 T171682_1 - 5.9e-05 23.2 1.5 0.00018 21.7 1.5 1.8 1 0 0 1 1 1 1 Zinc-finger double domain zf-H2C2_2 PF13465.4 T171682_2 - 3.6e-251 801.5 360.2 6.4e-09 35.7 0.8 44.5 45 1 0 45 45 45 38 Zinc-finger double domain zf-C2H2 PF00096.24 T171682_2 - 5.7e-148 473.6 297.4 2.3e-05 24.5 0.5 42.1 42 0 0 42 42 42 37 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T171682_2 - 5.1e-58 188.5 303.7 0.0084 16.7 0.4 41.1 43 0 0 43 43 42 31 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T171682_2 - 8.2e-33 111.6 250.7 0.0053 16.5 0.5 38.2 39 0 0 39 39 39 19 C2H2-type zinc finger XPA_N PF01286.16 T171682_2 - 1.4e-23 82.5 215.9 0.35 10.8 0.2 38.5 39 0 0 39 39 39 21 XPA protein N-terminal KRAB PF01352.25 T171682_2 - 1.1e-22 79.3 0.6 2.5e-22 78.1 0.6 1.6 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 T171682_2 - 1.1e-19 70.2 236.8 0.051 13.6 2.7 28.5 18 9 16 34 34 34 20 Zinc ribbon domain zf-C2H2_11 PF16622.3 T171682_2 - 1.3e-13 50.3 167.8 0.033 13.8 0.2 33.8 37 0 0 37 37 37 13 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 T171682_2 - 1.9e-07 31.1 212.6 0.02 15.1 0.3 35.9 38 0 0 38 38 37 9 Zinc-finger double-stranded RNA-binding DUF2790 PF10976.6 T171682_2 - 0.0012 18.6 0.7 86 3.1 0.0 5.4 5 0 0 5 5 5 0 Protein of unknown function (DUF2790) zf-C2H2_8 PF15909.3 T171682_2 - 0.033 14.3 168.8 0.17 12.1 1.9 19.6 3 1 23 27 27 27 0 C2H2-type zinc ribbon BHD_1 PF10403.7 T171682_2 - 0.24 11.1 31.7 79 3.1 0.1 15.0 17 3 2 19 19 19 0 Rad4 beta-hairpin domain 1 zf-C2H2 PF00096.24 T171682_3 - 3.4e-07 30.2 37.1 0.011 16.1 0.8 8.6 9 0 0 9 9 9 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T171682_3 - 2.6e-06 27.5 29.4 0.15 12.4 0.8 6.8 5 1 0 5 5 5 4 Zinc-finger double domain HTH_8 PF02954.17 T171682_3 - 0.035 13.8 2.4 1.7e+02 1.9 0.0 7.5 9 0 0 9 9 9 0 Bacterial regulatory protein, Fis family zf-trcl PF13451.4 T171682_3 - 4.2 7.2 9.6 8.4 6.2 0.1 4.1 4 0 0 4 4 4 0 Probable zinc-ribbon domain zf-C2H2_6 PF13912.4 T171682_3 - 6.1 6.8 13.3 5.5 6.9 0.0 5.4 5 0 0 5 5 5 0 C2H2-type zinc finger XPA_N PF01286.16 T171682_3 - 9.9 6.2 17.8 6.6 6.7 0.9 4.4 4 0 0 4 4 4 0 XPA protein N-terminal Miff PF05644.9 T381741_3 - 1.8e-11 44.1 6.0 4.5e-11 42.8 6.0 1.6 1 1 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff Hydrolase_like PF13242.4 T161767_3 - 4.3e-17 61.8 0.0 7.3e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.4 T161767_3 - 3.4e-08 33.4 0.0 6.1e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 T161767_3 - 0.00014 21.8 0.0 0.00023 21.2 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 T161767_3 - 0.041 14.0 0.0 0.058 13.5 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Caprin-1_C PF12287.6 T076162_1 - 2.1e-112 376.4 44.2 2.1e-112 376.4 44.2 3.8 3 2 0 3 3 3 1 Cytoplasmic activation/proliferation-associated protein-1 C term C1q PF00386.19 T076162_1 - 9.3e-33 113.0 0.0 1.9e-32 112.0 0.0 1.6 1 0 0 1 1 1 1 C1q domain Sialidase_penC PF12135.6 T076162_2 - 0.092 12.4 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Sialidase enzyme penultimate C terminal domain MFS_1 PF07690.14 T139925_1 - 2.8e-34 118.5 28.0 3.9e-34 118.0 28.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 T139925_1 - 3.8e-09 35.8 6.6 3.8e-09 35.8 6.6 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.18 T139925_1 - 8.9e-06 24.1 12.9 0.0046 15.2 1.6 3.2 2 2 1 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family TRI12 PF06609.11 T139925_1 - 0.0019 16.5 3.7 0.0031 15.9 3.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.4 T139925_1 - 0.16 10.3 13.6 0.019 13.4 5.2 2.3 1 1 1 2 2 2 0 MFS/sugar transport protein EMP70 PF02990.14 T139925_1 - 1.2 7.6 4.8 43 2.4 4.8 2.2 1 1 0 1 1 1 0 Endomembrane protein 70 Anth_Ig PF05587.11 T041383_1 - 7.1e-05 23.1 0.1 0.00011 22.5 0.1 1.3 1 0 0 1 1 1 1 Anthrax receptor extracellular domain Anth_Ig PF05587.11 T041383_2 - 3.4e-15 56.3 0.1 6.1e-15 55.4 0.1 1.3 1 0 0 1 1 1 1 Anthrax receptor extracellular domain VWA PF00092.26 T041383_2 - 1.1e-10 42.0 0.1 4.1e-10 40.1 0.2 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.4 T041383_2 - 0.028 15.0 0.0 0.17 12.4 0.0 2.1 2 0 0 2 2 2 0 von Willebrand factor type A domain Synaptobrevin PF00957.19 T141331_3 - 1.5e-33 114.3 3.1 2e-33 113.9 3.1 1.2 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.11 T141331_3 - 0.031 14.3 0.0 0.047 13.7 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF912 PF06024.10 T141331_3 - 0.072 13.3 0.2 0.12 12.6 0.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Transglut_core2 PF13369.4 T087330_2 - 1.5e-39 134.9 0.0 2.1e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase-like superfamily YccV-like PF08755.9 T087330_2 - 1.4e-28 99.2 0.4 3.4e-28 97.9 0.1 1.8 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like F-box-like PF12937.5 T087330_2 - 4e-05 23.3 0.1 0.00024 20.8 0.0 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 T087330_2 - 0.0048 16.6 0.3 0.015 15.0 0.3 1.9 1 0 0 1 1 1 1 F-box domain DnaJ PF00226.29 T126503_3 - 4.6e-27 93.8 6.7 7.8e-27 93.1 6.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.16 T126503_3 - 2.6e-24 85.9 0.0 3.5e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.17 T126503_3 - 6.7e-10 39.1 15.0 1.6e-09 37.9 15.0 1.7 1 0 0 1 1 1 1 DnaJ central domain P12 PF12669.5 T179943_3 - 1.5 9.2 7.9 0.38 11.1 4.2 1.9 2 0 0 2 2 2 0 Virus attachment protein p12 family GSAP-16 PF14959.4 T327214_2 - 1.2e-38 131.2 0.2 2.7e-38 130.0 0.2 1.6 1 0 0 1 1 1 1 gamma-Secretase-activating protein C-term MARVEL PF01284.21 T016883_1 - 1.4e-30 106.1 2.5 1.4e-30 106.1 2.5 2.6 2 0 0 2 2 2 2 Membrane-associating domain Cytochrom_B561 PF03188.14 T016883_2 - 8.3e-37 126.2 11.7 1.3e-36 125.6 11.7 1.3 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 SCA7 PF08313.10 T016883_2 - 1.6e-23 82.2 3.8 1.6e-23 82.2 3.8 2.5 2 0 0 2 2 2 1 SCA7, zinc-binding domain BPS PF08947.8 T323940_3 - 2.2e-28 97.6 0.7 4.3e-28 96.7 0.7 1.5 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 T323940_3 - 2.5e-13 49.7 0.0 4.5e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 T323940_3 - 2.5e-10 40.7 0.2 5.3e-10 39.7 0.2 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 T323940_3 - 5.3e-09 36.4 0.9 7.9e-09 35.9 0.1 1.8 2 0 0 2 2 2 1 PH domain zf-H2C2_2 PF13465.4 T353396_3 - 1.6e-51 170.4 58.9 1.9e-07 31.1 0.1 10.3 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2 PF00096.24 T353396_3 - 6.6e-35 117.5 63.2 0.0001 22.4 0.3 9.8 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T353396_3 - 5.2e-13 48.5 63.1 0.086 13.6 0.4 10.2 9 0 0 9 9 9 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T353396_3 - 0.0028 17.6 34.8 0.48 10.5 1.6 5.9 4 2 0 5 5 5 3 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T353396_3 - 0.56 10.9 20.8 5.7 7.6 2.6 4.6 1 1 4 5 5 5 0 zinc-ribbon family XPA_N PF01286.16 T353396_3 - 1.1 9.2 26.1 7 6.6 0.0 7.4 8 0 0 8 8 8 0 XPA protein N-terminal zf-H2C2_2 PF13465.4 T299794_2 - 4.2e-34 115.3 22.5 8.6e-09 35.3 0.1 6.7 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 T299794_2 - 1.1e-23 82.1 44.5 2.5e-06 27.5 1.3 6.2 7 0 0 7 7 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T299794_2 - 6.8e-14 51.2 41.2 0.0042 17.7 0.9 6.1 6 0 0 6 6 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T299794_2 - 4.4e-07 29.6 40.8 0.091 12.6 1.3 5.8 6 0 0 6 6 5 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T299794_2 - 1.7e-05 24.7 18.0 0.0026 17.7 1.5 3.7 2 1 2 4 4 4 2 Zinc ribbon domain FYVE PF01363.19 T299794_2 - 0.0041 17.1 3.4 0.0041 17.1 3.4 4.1 2 1 2 4 4 4 2 FYVE zinc finger XPA_N PF01286.16 T299794_2 - 0.011 15.7 21.0 1 9.3 1.3 5.3 5 0 0 5 5 5 0 XPA protein N-terminal zf-C2H2_11 PF16622.3 T299794_2 - 0.16 11.6 30.3 0.16 11.6 0.8 5.4 5 0 0 5 5 5 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 T299794_2 - 0.19 12.3 16.5 2.4 8.8 0.9 3.3 1 1 2 3 3 3 0 zinc-ribbon family YhfH PF14149.4 T299794_2 - 1.9 8.4 14.9 33 4.4 0.5 4.8 4 0 0 4 4 4 0 YhfH-like protein C1_4 PF07975.10 T299794_2 - 7.5 6.8 19.4 0.85 9.8 0.4 3.8 1 1 1 3 3 3 0 TFIIH C1-like domain zf-C2H2_jaz PF12171.6 T299794_2 - 7.6 6.9 24.3 31 4.9 2.2 5.4 4 1 1 5 5 5 0 Zinc-finger double-stranded RNA-binding ADK_lid PF05191.12 T299794_2 - 8 6.4 15.0 28 4.7 0.1 5.0 4 1 2 6 6 6 0 Adenylate kinase, active site lid SCAN PF02023.15 T299794_3 - 9.9e-41 137.4 2.2 2.7e-40 136.0 2.2 1.8 1 0 0 1 1 1 1 SCAN domain TYW3 PF02676.12 T013316_1 - 9.6e-55 185.1 0.3 1.4e-54 184.5 0.3 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 Aminotran_3 PF00202.19 T280883_2 - 1.4e-76 257.7 0.1 2.6e-43 148.1 0.1 2.1 1 1 1 2 2 2 2 Aminotransferase class-III PP2C PF00481.19 T186747_1 - 1.4e-73 247.6 0.2 1.3e-56 192.0 0.4 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.4 T186747_1 - 0.075 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein phosphatase 2C Cwf_Cwc_15 PF04889.10 T186747_1 - 1.4 8.5 24.0 4 7.0 2.8 2.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein zf-H2C2_2 PF13465.4 T186747_3 - 1.1e-39 133.0 79.4 1.3e-09 37.9 2.4 9.8 10 0 0 10 10 10 7 Zinc-finger double domain zf-H2C2_5 PF13909.4 T186747_3 - 3.6e-30 103.2 52.8 7.7e-05 22.2 0.3 8.5 8 0 0 8 8 8 8 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 T186747_3 - 2.2e-13 49.7 90.4 0.00078 19.6 4.6 10.1 10 0 0 10 10 10 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T186747_3 - 2 9.3 72.5 0.045 14.5 2.9 9.9 9 0 0 9 9 9 0 C2H2-type zinc finger GAGA PF09237.9 T186747_3 - 3.6 7.3 19.4 0.28 10.9 0.8 4.5 2 2 3 5 5 5 0 GAGA factor Nuc_sug_transp PF04142.13 T307721_2 - 9.4e-117 389.5 34.6 4.3e-65 219.8 9.0 2.1 2 0 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.18 T307721_2 - 5.6 7.0 27.2 0.22 11.5 4.9 2.8 2 1 0 2 2 2 0 EamA-like transporter family PID PF00640.21 T011748_2 - 2.5e-08 33.9 0.1 4.1e-08 33.2 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) DUF4586 PF15239.4 T275776_1 - 1e-06 29.0 0.4 1.5e-06 28.5 0.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4586) DUF4586 PF15239.4 T275776_2 - 1.4e-34 120.5 5.1 1.9e-34 120.1 5.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) DUF4586 PF15239.4 T275776_3 - 3.3e-16 60.2 5.0 4.7e-16 59.7 5.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) Myotub-related PF06602.12 T113674_2 - 1.1e-70 238.2 2.8 1.9e-57 194.6 1.9 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain 3-PAP PF12578.6 T113674_2 - 4.3e-56 188.2 0.1 6.7e-56 187.5 0.1 1.3 1 0 0 1 1 1 1 Myotubularin-associated protein fn3 PF00041.19 T083010_2 - 1.6e-136 444.8 50.2 2.1e-12 47.1 0.1 16.1 16 0 0 16 16 16 14 Fibronectin type III domain Y_phosphatase PF00102.25 T083010_2 - 1.1e-75 254.2 0.0 2.4e-75 253.0 0.0 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pur_ac_phosph_N PF16656.3 T083010_2 - 1.7e-13 50.8 47.4 0.00055 20.3 0.3 13.9 14 3 0 14 14 14 6 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 T083010_2 - 8e-08 32.2 11.9 0.43 10.6 0.0 9.0 8 0 0 8 8 8 1 Fibronectin type III domain Interfer-bind PF09294.8 T083010_2 - 7.3e-06 26.1 14.1 4.8 7.4 0.1 8.5 10 0 0 10 10 10 2 Interferon-alpha/beta receptor, fibronectin type III Y_phosphatase3 PF13350.4 T083010_2 - 0.0016 18.3 0.0 0.003 17.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 T083010_2 - 0.073 12.8 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain SusE PF14292.4 T083010_2 - 0.11 12.7 12.3 19 5.6 0.0 7.0 7 0 0 7 7 7 0 SusE outer membrane protein PTPlike_phytase PF14566.4 T083010_2 - 0.12 12.4 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate BTB PF00651.29 T222626_1 - 3e-25 88.5 1.2 4.2e-25 88.0 1.2 1.2 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.6 T222626_1 - 2.7e-06 27.4 0.3 4.3e-06 26.7 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BTB_3 PF16017.3 T222626_1 - 0.011 15.7 0.1 0.021 14.8 0.1 1.4 1 0 0 1 1 1 0 BTB/POZ domain Spatacsin_C PF14649.4 T115781_1 - 3.6e-102 341.4 4.5 9e-102 340.1 4.5 1.7 1 0 0 1 1 1 1 Spatacsin C-terminus PAT1 PF09770.7 T115781_1 - 5.4e-12 44.7 0.1 1.7e-10 39.8 0.0 2.2 2 0 0 2 2 2 2 Topoisomerase II-associated protein PAT1 SSF PF00474.15 T085073_2 - 3.4e-39 134.7 26.3 4.4e-39 134.4 26.3 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family PID PF00640.21 T263882_3 - 1.8e-49 167.3 0.0 5.4e-37 126.8 0.0 2.3 2 0 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.24 T263882_3 - 6.1e-06 25.9 2.6 1.3e-05 24.9 2.6 1.6 1 0 0 1 1 1 1 WW domain PTB PF08416.11 T263882_3 - 2.1e-05 24.5 0.0 0.0022 18.0 0.0 2.4 2 0 0 2 2 2 2 Phosphotyrosine-binding domain SBF2 PF12335.6 T054680_3 - 2.5e-105 351.0 2.8 4.5e-105 350.2 2.8 1.4 1 0 0 1 1 1 1 Myotubularin protein Myotub-related PF06602.12 T054680_3 - 4.8e-82 275.5 0.2 9.2e-82 274.6 0.2 1.4 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DENN PF02141.19 T054680_3 - 3.6e-54 183.4 0.6 7.7e-54 182.3 0.6 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 T054680_3 - 3.3e-19 69.3 0.4 3.3e-19 69.3 0.4 2.7 3 0 0 3 3 3 1 uDENN domain GRAM PF02893.18 T054680_3 - 1.7e-14 53.4 0.0 6e-14 51.7 0.0 2.0 2 0 0 2 2 2 1 GRAM domain PH PF00169.27 T054680_3 - 2.7e-14 53.4 0.0 7.7e-14 52.0 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 T054680_3 - 0.00025 21.1 0.0 0.00065 19.8 0.0 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 T054680_3 - 0.00056 19.8 0.0 0.0016 18.3 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 T054680_3 - 0.0012 19.1 0.0 0.0035 17.6 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.8 T054680_3 - 0.0082 16.3 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 Plant pleckstrin homology-like region EBP PF05241.10 T094518_3 - 2.5e-43 147.5 5.4 2.5e-43 147.5 5.4 1.7 2 0 0 2 2 2 1 Emopamil binding protein Kinesin PF00225.21 T303087_2 - 2.5e-97 325.6 0.2 4.3e-97 324.9 0.2 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 T303087_2 - 9.1e-28 97.0 0.1 1.7e-27 96.1 0.1 1.4 1 0 0 1 1 1 1 Microtubule binding JmjC PF02373.20 T373751_1 - 1.3e-32 112.5 1.0 1.3e-32 112.5 1.0 1.8 2 0 0 2 2 1 1 JmjC domain, hydroxylase TPR_1 PF00515.26 T373751_1 - 9.2e-26 88.4 15.3 2.6e-05 23.7 0.0 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 T373751_1 - 7.7e-15 53.6 14.7 0.022 14.7 0.1 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.4 T373751_1 - 1.4e-12 48.0 2.1 0.0085 16.6 0.6 4.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.4 T373751_1 - 9.4e-12 44.0 13.1 0.01 15.9 0.4 7.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.4 T373751_1 - 3.2e-11 42.7 0.2 0.016 15.5 0.0 4.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 T373751_1 - 1.9e-09 37.5 7.0 0.21 11.8 0.2 4.6 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.4 T373751_1 - 3.6e-07 30.5 7.0 0.11 12.8 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.4 T373751_1 - 2.4e-05 23.9 5.3 2.6 8.2 0.3 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.4 T373751_1 - 2.6e-05 24.1 0.2 0.026 14.6 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 T373751_1 - 0.00017 22.0 3.1 4.6 8.2 0.0 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.4 T373751_1 - 0.0016 18.0 7.6 0.27 10.8 0.0 5.3 4 1 3 7 7 7 1 TPR repeat SNAP PF14938.4 T373751_1 - 0.17 11.1 12.9 0.12 11.7 1.1 2.9 2 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP TPR_15 PF13429.4 T373751_1 - 0.73 8.9 7.7 0.42 9.7 4.2 2.2 1 1 0 2 2 2 0 Tetratricopeptide repeat Arm PF00514.21 T059005_3 - 4.6e-28 96.2 5.8 4.3e-07 29.6 0.0 6.7 7 0 0 7 7 7 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 T059005_3 - 0.0045 17.3 0.1 36 4.8 0.0 3.9 3 0 0 3 3 3 1 HEAT-like repeat HEAT_2 PF13646.4 T059005_3 - 0.053 13.8 0.4 8.5 6.7 0.1 2.3 2 0 0 2 2 2 0 HEAT repeats RhoGEF PF00621.18 T362574_1 - 8.6e-45 153.1 0.0 1.7e-44 152.1 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 T362574_1 - 2.1e-12 47.4 0.0 3.5e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 PH domain FYVE PF01363.19 T362574_1 - 4e-12 46.0 15.8 9.2e-12 44.8 15.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.14 T362574_1 - 0.0074 16.4 8.3 0.0074 16.4 8.3 1.7 2 0 0 2 2 2 1 FYVE-type zinc finger IQ_SEC7_PH PF16453.3 T362574_1 - 0.051 13.4 0.1 0.089 12.7 0.1 1.2 1 0 0 1 1 1 0 PH domain PH_13 PF16652.3 T362574_1 - 0.15 11.8 0.9 0.32 10.7 0.9 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain PH PF00169.27 T362574_2 - 0.035 14.5 0.0 0.061 13.7 0.0 1.3 1 0 0 1 1 1 0 PH domain TPD52 PF04201.13 T346621_1 - 3.6e-75 250.9 7.8 5.1e-75 250.4 7.8 1.2 1 0 0 1 1 1 1 Tumour protein D52 family IncA PF04156.12 T346621_1 - 0.022 14.4 4.3 0.034 13.8 4.3 1.2 1 0 0 1 1 1 0 IncA protein Uds1 PF15456.4 T346621_1 - 0.07 13.2 6.0 0.12 12.4 6.0 1.3 1 0 0 1 1 1 0 Up-regulated During Septation Spc7 PF08317.9 T346621_1 - 0.24 10.1 6.5 0.35 9.5 6.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Cnn_1N PF07989.9 T346621_1 - 0.25 11.4 4.5 0.48 10.5 4.5 1.4 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Occludin_ELL PF07303.11 T346621_1 - 0.6 10.7 2.8 2.8 8.6 0.2 2.3 1 1 1 2 2 2 0 Occludin homology domain HsbA PF12296.6 T346621_1 - 0.79 10.0 5.8 0.46 10.8 0.7 2.2 1 1 1 2 2 2 0 Hydrophobic surface binding protein A TBPIP PF07106.11 T346621_1 - 2.2 7.9 9.9 3.8 7.1 7.1 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) AAA_13 PF13166.4 T346621_1 - 3.2 6.2 9.5 4.1 5.8 1.3 1.9 1 1 1 2 2 2 0 AAA domain OmpH PF03938.12 T346621_1 - 6.2 6.7 8.5 11 5.9 8.5 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Mnd1 PF03962.13 T346621_1 - 8.6 6.0 8.8 14 5.4 8.8 1.3 1 0 0 1 1 1 0 Mnd1 family MRP-S35 PF10246.7 T346621_2 - 1.2e-51 173.0 0.0 2.1e-51 172.2 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein MRP-S35 BEX PF04538.10 T378050_1 - 9.8e-18 64.9 5.2 1.9e-17 63.9 5.2 1.4 1 0 0 1 1 1 1 Brain expressed X-linked like family Ysc84 PF04366.10 T182727_1 - 1.2e-34 118.7 0.0 1.7e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.26 T182727_1 - 6.1e-15 54.4 0.0 1.2e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T182727_1 - 2.1e-14 53.0 0.0 3.2e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T182727_1 - 2.3e-10 39.9 0.0 4e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain AIP3 PF03915.11 T038457_3 - 1.7e-16 60.2 31.9 1.4e-10 40.7 0.1 4.6 5 0 0 5 5 5 4 Actin interacting protein 3 Peptidase_M14 PF00246.22 T333222_3 - 1.7e-80 270.8 0.0 2.1e-80 270.5 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.14 T333222_3 - 2.3e-18 66.2 0.0 4.3e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide NKAIN PF05640.12 T222246_1 - 3.8e-21 75.2 2.9 7.1e-21 74.3 2.9 1.3 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein NKAIN PF05640.12 T222246_2 - 5.2e-17 61.7 1.5 1e-08 34.6 1.3 2.2 2 0 0 2 2 2 2 Na,K-Atpase Interacting protein NKAIN PF05640.12 T222246_3 - 3.2e-06 26.5 0.0 4.8e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein ACBP PF00887.17 T038799_3 - 5.2e-26 90.5 0.1 9.2e-26 89.8 0.1 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein Leuk-A4-hydro_C PF09127.9 T362955_1 - 4.4e-17 62.3 0.9 7.5e-17 61.5 0.9 1.3 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1 PF01433.18 T362955_1 - 5.9e-12 45.4 0.0 8.9e-12 44.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Mob1_phocein PF03637.15 T205424_2 - 2.7e-32 112.0 0.7 4.5e-32 111.3 0.7 1.2 1 0 0 1 1 1 1 Mob1/phocein family SRCR PF00530.16 T326964_1 - 1.9e-30 105.2 2.4 1.9e-30 105.2 2.4 1.5 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 T326964_1 - 0.0033 17.8 0.3 0.007 16.7 0.3 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF4147 PF13660.4 T243301_1 - 3.7e-66 222.8 1.0 7e-66 221.9 1.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) HAD PF12710.5 T243301_1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DIMCO_N PF16844.3 T243301_1 - 0.32 11.2 4.1 0.16 12.2 1.8 1.7 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal 7tm_1 PF00001.19 T221642_3 - 5.1e-61 206.1 0.0 6.9e-61 205.7 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T221642_3 - 4.8e-05 22.7 5.7 0.0022 17.3 0.9 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 T221642_3 - 0.013 15.1 1.2 0.025 14.2 1.2 1.4 1 0 0 1 1 1 0 Olfactory receptor 7TM_GPCR_Srx PF10328.7 T221642_3 - 0.46 9.6 12.8 0.05 12.8 8.5 1.5 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF621 PF04789.13 T221642_3 - 3.2 6.7 7.0 4.7 6.2 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF621) Aa_trans PF01490.16 T077393_1 - 4e-13 48.7 8.5 5.5e-13 48.3 8.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.16 T077393_3 - 1.7e-37 129.0 12.0 3e-37 128.2 12.0 1.3 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein NDK PF00334.17 T321794_1 - 4.1e-14 52.6 0.0 6.8e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase NDK PF00334.17 T321794_2 - 9.2e-26 90.3 0.9 5.7e-23 81.3 0.0 3.8 3 2 2 5 5 5 1 Nucleoside diphosphate kinase Thioredoxin PF00085.18 T321794_2 - 2.2e-11 43.5 2.5 2.2e-11 43.5 0.1 2.1 2 0 0 2 2 2 1 Thioredoxin Redoxin PF08534.8 T321794_2 - 0.016 14.8 0.0 0.033 13.7 0.0 1.5 1 0 0 1 1 1 0 Redoxin AhpC-TSA PF00578.19 T321794_2 - 0.029 14.2 0.1 0.07 12.9 0.1 1.6 1 0 0 1 1 1 0 AhpC/TSA family Collagen PF01391.16 T269432_2 - 3.6e-64 212.3 299.5 1.3e-09 37.5 31.0 9.9 4 2 6 10 10 10 9 Collagen triple helix repeat (20 copies) MAGE_N PF12440.6 T269432_3 - 0.32 11.6 1.2 0.64 10.6 1.2 1.5 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal Integrase_AP2 PF14657.4 T269432_3 - 3 7.5 5.9 5.6 6.7 5.9 1.4 1 0 0 1 1 1 0 AP2-like DNA-binding integrase domain TMEM51 PF15345.4 T334836_1 - 0.0012 18.6 7.5 0.0023 17.7 7.5 1.4 1 1 0 1 1 1 1 Transmembrane protein 51 Gpi1 PF05024.13 T124256_2 - 4.8e-65 219.1 7.5 6.5e-65 218.6 7.5 1.2 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Ras PF00071.20 T124256_2 - 8.1e-38 129.4 0.0 1.1e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T124256_2 - 1.1e-19 70.7 0.0 1.6e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SOCS_box PF07525.14 T124256_2 - 6.6e-06 26.2 0.4 6.6e-06 26.2 0.4 3.1 2 0 0 2 2 2 1 SOCS box Arf PF00025.19 T124256_2 - 0.0012 18.2 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Kunitz_BPTI PF00014.21 T124256_3 - 4.5e-25 87.5 7.6 2.5e-17 62.7 1.7 2.8 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Ig_3 PF13927.4 T124256_3 - 3.7e-15 56.1 0.1 1e-14 54.8 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T124256_3 - 3.5e-14 52.5 0.0 5.3e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 T124256_3 - 3.1e-10 40.1 0.0 8.1e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain WAP PF00095.19 T124256_3 - 4.6e-08 33.2 10.8 4.6e-08 33.2 10.8 7.1 7 0 0 7 7 7 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' V-set PF07686.15 T124256_3 - 3.5e-05 23.8 0.0 8.8e-05 22.5 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain Kazal_2 PF07648.13 T124256_3 - 0.00014 21.8 0.5 0.00045 20.2 0.5 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain SH3_9 PF14604.4 T290396_1 - 3.5e-20 71.5 1.4 2.2e-09 36.9 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 T290396_1 - 4.2e-16 58.1 0.3 4.3e-08 32.5 0.2 2.5 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.15 T290396_1 - 7.2e-16 57.5 0.1 2e-07 30.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain RhoGAP PF00620.25 T290396_1 - 5e-10 39.2 0.0 8.1e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain hSH3 PF14603.4 T290396_1 - 0.0057 17.0 0.0 0.0099 16.3 0.0 1.2 1 0 0 1 1 1 1 Helically-extended SH3 domain SH3_3 PF08239.9 T290396_1 - 0.032 14.4 0.3 0.07 13.3 0.3 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain FCH PF00611.21 T290396_2 - 1.2e-16 60.6 2.0 2.7e-16 59.5 0.1 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain RhoGAP PF00620.25 T290396_2 - 2.5e-14 53.2 0.0 6.9e-14 51.8 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.27 T290396_2 - 5.9e-12 45.9 0.0 2.3e-08 34.4 0.0 3.3 3 0 0 3 3 3 2 PH domain RA PF00788.21 T290396_2 - 1.7e-11 44.5 0.0 3.1e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain ArfGap PF01412.16 T290396_3 - 9.3e-30 102.9 0.0 1.9e-29 102.0 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.27 T290396_3 - 3e-17 62.9 0.0 6.2e-12 45.8 0.0 2.6 3 0 0 3 3 3 2 PH domain SAM_2 PF07647.15 T290396_3 - 3.3e-11 43.0 0.1 5.9e-11 42.2 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 T290396_3 - 2.6e-09 37.2 0.0 5.9e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_3 PF14593.4 T290396_3 - 2.4e-05 24.3 0.0 0.0024 17.8 0.0 2.2 2 0 0 2 2 2 1 PH domain PH_8 PF15409.4 T290396_3 - 4.6e-05 23.5 0.0 0.00012 22.1 0.0 1.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.4 T290396_3 - 8.1e-05 22.8 0.0 0.00024 21.3 0.0 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.8 T290396_3 - 0.016 15.4 0.1 0.8 10.0 0.1 2.2 2 0 0 2 2 2 0 Plant pleckstrin homology-like region RhoGAP PF00620.25 T217632_2 - 2.2e-39 134.5 0.2 3.6e-39 133.9 0.2 1.3 1 0 0 1 1 1 1 RhoGAP domain V-set PF07686.15 T179807_1 - 6.6e-26 90.5 7.0 1.2e-11 44.6 0.3 4.8 4 1 1 5 5 5 2 Immunoglobulin V-set domain Ig_3 PF13927.4 T179807_1 - 1.4e-20 73.6 7.2 8.4e-10 39.0 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 T179807_1 - 1.5e-15 56.9 0.0 4.7e-08 32.8 0.0 4.3 4 1 0 4 4 4 3 Immunoglobulin I-set domain ig PF00047.23 T179807_1 - 4.2e-15 55.5 5.1 0.00012 22.0 0.0 4.7 4 1 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 T179807_1 - 2.9e-14 53.0 6.4 1.1e-07 32.0 0.0 4.3 4 1 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.10 T179807_1 - 0.00019 21.3 8.5 0.0076 16.2 2.6 4.0 2 2 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.6 T179807_1 - 0.055 13.5 0.0 3.3 7.8 0.0 2.4 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 Motilin_ghrelin PF04644.10 T179807_3 - 0.23 11.2 3.8 4.7 7.0 1.0 2.5 2 0 0 2 2 2 0 Motilin/ghrelin Hydrolase PF00702.24 T324601_1 - 9.5e-16 58.6 0.0 1.3e-15 58.1 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 T324601_1 - 5e-11 43.2 0.0 8.7e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.10 T324601_1 - 0.00014 21.4 0.0 0.00021 20.8 0.0 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD_2 PF13419.4 T324601_1 - 0.0016 18.5 0.0 0.19 11.7 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.10 T324601_1 - 0.0044 16.3 0.0 0.0096 15.2 0.0 1.4 1 1 0 1 1 1 1 Putative Phosphatase Toxin_18 PF08087.9 T324601_1 - 0.011 15.6 0.9 4 7.4 1.6 2.8 2 0 0 2 2 2 0 Conotoxin O-superfamily StbA PF06406.9 T324601_1 - 0.19 10.8 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 StbA protein DUF4710 PF15828.3 T126269_2 - 0.55 10.3 5.1 1 9.4 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) 7tm_4 PF13853.4 T126269_3 - 3e-47 161.5 6.3 4.8e-47 160.9 6.3 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T126269_3 - 1.6e-25 89.7 9.5 3.2e-25 88.7 9.5 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-H2C2_2 PF13465.4 T126269_3 - 2.5e-24 84.4 39.3 8.6e-06 25.8 1.2 6.1 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.24 T126269_3 - 9.6e-24 82.3 46.1 3e-05 24.1 0.7 6.0 5 0 0 5 5 5 5 Zinc finger, C2H2 type KRAB PF01352.25 T126269_3 - 3e-21 74.7 1.9 5.6e-21 73.8 1.9 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T126269_3 - 2.7e-13 49.4 40.7 0.01 16.5 1.8 6.4 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T126269_3 - 2.2e-06 27.3 31.3 0.032 14.1 0.3 5.6 5 0 0 5 5 5 4 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T126269_3 - 0.021 14.8 15.7 0.13 12.3 2.9 3.4 2 1 1 3 3 3 0 Zinc ribbon domain zf-C2H2_8 PF15909.3 T126269_3 - 0.057 13.6 15.2 0.012 15.8 2.2 2.7 1 1 1 2 2 2 0 C2H2-type zinc ribbon DUF3268 PF11672.6 T126269_3 - 0.077 13.2 3.7 5.1 7.3 0.4 2.4 2 0 0 2 2 2 0 zinc-finger-containing domain zf-C2H2_jaz PF12171.6 T126269_3 - 1.5 9.1 33.3 3.1 8.1 1.2 6.6 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding GAGA PF09237.9 T126269_3 - 2.2 8.0 6.8 0.91 9.3 1.4 2.6 2 0 0 2 2 2 0 GAGA factor TROVE PF05731.9 T027074_3 - 4.1e-43 147.8 3.3 5.5e-43 147.3 3.3 1.1 1 0 0 1 1 1 1 TROVE domain VWA_2 PF13519.4 T027074_3 - 0.15 12.6 0.1 0.24 12.0 0.1 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain Ras PF00071.20 T197286_1 - 1.8e-08 34.0 0.1 1.9e-06 27.4 0.0 2.2 1 1 1 2 2 2 2 Ras family Roc PF08477.11 T197286_1 - 4e-08 33.4 0.0 6.2e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase V-set PF07686.15 T321855_1 - 4.8e-14 52.3 0.0 1.5e-13 50.7 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin V-set domain C1-set PF07654.13 T321855_1 - 8.3e-11 42.1 0.2 4.5e-09 36.5 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 T321855_1 - 2e-05 25.0 0.5 6.6e-05 23.3 0.2 2.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 T321855_1 - 0.0015 18.5 5.3 0.27 11.3 0.1 3.3 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.14 T321855_1 - 0.0087 16.0 0.1 0.021 14.8 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain C1-set PF07654.13 T321855_3 - 5.6e-09 36.2 0.1 1.1e-08 35.2 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Shugoshin_C PF07557.9 T238991_1 - 7.9e-10 38.2 1.3 1.8e-09 37.1 1.3 1.7 1 0 0 1 1 1 1 Shugoshin C terminus Shugoshin_N PF07558.9 T238991_3 - 7.7e-11 41.6 2.2 7.7e-11 41.6 2.2 1.7 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region DUF2353 PF09789.7 T238991_3 - 0.1 11.8 6.5 0.14 11.4 6.5 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) 2-Hacid_dh_C PF02826.17 T050374_3 - 2.1e-54 183.4 0.0 2.9e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 T050374_3 - 2.6e-28 98.2 0.0 3.5e-28 97.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 T050374_3 - 0.0033 17.5 0.0 0.005 16.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase PHD20L1_u1 PF16660.3 T351910_1 - 2.3e-50 169.2 9.4 2.3e-50 169.2 9.4 1.9 2 0 0 2 2 2 1 PHD finger protein 20-like protein 1 DUF3776 PF12618.6 T351910_1 - 3.4e-33 113.9 1.8 3.4e-33 113.9 1.8 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3776) PHD PF00628.27 T351910_1 - 5.8e-06 26.0 11.2 5.8e-06 26.0 11.2 2.1 2 0 0 2 2 2 1 PHD-finger MBT PF02820.16 T351910_1 - 9.4e-05 22.6 0.1 0.00045 20.4 0.0 2.0 2 0 0 2 2 2 1 mbt repeat DUF4537 PF15057.4 T351910_1 - 0.023 14.6 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) LBR_tudor PF09465.8 T351910_1 - 0.043 13.5 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Tudor-knot PF11717.6 T351910_1 - 2.3 8.1 4.5 1.2 9.0 2.1 1.8 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain FAM60A PF15396.4 T351910_1 - 3.4 7.5 18.4 4.8 7.0 5.8 2.7 2 0 0 2 2 2 0 Protein Family FAM60A DPPIV_N PF00930.19 T336429_1 - 5.7e-111 370.6 0.1 9.2e-111 369.9 0.1 1.4 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 T336429_1 - 7.6e-39 133.3 0.4 1.6e-38 132.2 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family PD40 PF07676.10 T336429_1 - 4.5e-07 29.5 0.4 0.12 12.3 0.0 4.1 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat DLH PF01738.16 T336429_1 - 0.032 13.7 0.1 0.12 11.8 0.1 1.8 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF872 PF05915.10 T336429_1 - 0.046 13.8 0.0 0.098 12.8 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) SprT-like PF10263.7 T032778_2 - 1.3e-42 145.2 1.6 1.3e-42 145.2 1.6 1.6 2 0 0 2 2 2 1 SprT-like family PRP21_like_P PF12230.6 T032778_2 - 0.082 12.6 0.6 0.17 11.6 0.6 1.4 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein zf-C2H2 PF00096.24 T214339_1 - 2e-12 46.7 27.5 0.0013 19.0 3.0 5.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T214339_1 - 2.3e-12 46.6 20.2 1.1e-07 31.8 0.6 5.1 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 T214339_1 - 0.0083 16.7 1.5 0.0083 16.7 1.5 6.2 6 0 0 6 6 6 3 C2H2-type zinc finger zf-met PF12874.5 T214339_1 - 4.8 7.6 14.1 0.42 10.9 2.9 3.9 2 1 1 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T214339_1 - 9.9 6.5 13.5 5.2 7.4 0.4 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding ABC_tran PF00005.25 T153178_2 - 1.2e-56 190.9 0.1 1.3e-28 100.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.5 T153178_2 - 3.3e-40 138.1 54.7 7.8e-28 97.4 25.6 3.0 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.4 T153178_2 - 9.6e-19 68.2 9.3 5e-08 33.0 0.1 4.9 3 2 2 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 T153178_2 - 3.9e-07 30.0 2.0 0.0017 18.2 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_29 PF13555.4 T153178_2 - 9e-06 25.2 3.3 0.0087 15.6 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.21 T153178_2 - 0.0072 16.3 1.7 2.1 8.3 0.1 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.4 T153178_2 - 0.036 14.3 0.1 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_15 PF13175.4 T153178_2 - 0.039 13.4 1.0 7.6 5.9 0.0 3.1 3 0 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.4 T153178_2 - 0.1 12.7 0.4 4.8 7.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.4 T153178_2 - 0.11 12.8 11.9 0.2 12.0 0.1 2.9 3 0 0 3 3 3 0 AAA domain DUF4162 PF13732.4 T153178_2 - 0.14 12.8 0.2 6.9 7.3 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) AAA_30 PF13604.4 T153178_2 - 0.23 11.0 1.9 10 5.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.25 T153178_3 - 2.9e-56 189.7 0.3 2e-30 105.9 0.4 2.3 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.5 T153178_3 - 7.1e-38 130.5 66.0 6.9e-26 91.0 37.8 2.5 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.4 T153178_3 - 4.2e-14 52.9 12.7 2.7e-05 24.0 0.3 4.2 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 T153178_3 - 5.6e-07 29.5 0.9 0.00049 19.9 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 DUF1725 PF08333.9 T153178_3 - 1.6e-06 27.5 1.2 1.6e-06 27.5 1.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) AAA_29 PF13555.4 T153178_3 - 7.3e-05 22.3 0.9 0.02 14.5 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.4 T153178_3 - 0.0012 18.4 2.7 1.4 8.3 0.0 3.4 3 0 0 3 3 3 2 AAA ATPase domain AAA_23 PF13476.4 T153178_3 - 0.002 18.6 1.7 0.49 10.7 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.4 T153178_3 - 0.0024 18.2 0.1 0.66 10.2 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain DUF4162 PF13732.4 T153178_3 - 0.14 12.8 0.1 3.2 8.4 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) MMR_HSR1 PF01926.21 T153178_3 - 0.15 12.0 1.1 1.1 9.3 0.1 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase SMC_N PF02463.17 T153178_3 - 0.47 9.7 4.0 17 4.6 0.8 3.4 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain WGG PF10273.7 T375159_2 - 1.2e-24 86.6 0.1 2.1e-24 85.8 0.1 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 FWWh PF14922.4 T116469_2 - 7.6e-28 97.2 6.2 2.7e-15 56.5 0.2 2.4 1 1 1 2 2 2 2 Protein of unknown function Sushi PF00084.18 T024820_2 - 7e-67 221.8 78.2 2.2e-10 40.9 4.6 8.7 8 0 0 8 8 8 8 Sushi repeat (SCR repeat) Lectin_C PF00059.19 T024820_2 - 8.2e-23 81.1 8.3 2.1e-22 79.8 8.3 1.8 1 0 0 1 1 1 1 Lectin C-type domain EGF PF00008.25 T024820_2 - 6.1e-05 23.1 10.6 0.00056 20.0 8.4 4.2 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.11 T024820_2 - 0.0018 18.5 9.1 0.0018 18.5 9.1 3.6 2 0 0 2 2 2 1 EGF-like domain Ig_2 PF13895.4 T181042_2 - 3e-09 37.0 0.0 0.00062 19.9 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 T181042_2 - 6.7e-07 29.7 0.0 0.0011 19.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 T181042_2 - 0.0029 17.6 0.0 0.015 15.3 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain PP2C PF00481.19 T105416_2 - 2.7e-89 299.1 0.0 3.3e-89 298.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.11 T105416_2 - 9.7e-12 45.0 0.0 1.8e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain Ank_2 PF12796.5 T194655_1 - 1.5e-24 86.2 1.4 4.4e-11 43.1 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 T194655_1 - 2.2e-18 65.7 6.4 3.1e-05 24.1 0.1 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.4 T194655_1 - 2.3e-17 63.0 2.2 5.4e-06 26.7 0.0 3.8 2 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 T194655_1 - 1.6e-16 58.6 3.8 0.0099 16.2 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.4 T194655_1 - 2.8e-16 59.2 7.0 4.2e-10 39.6 0.3 4.3 2 1 3 5 5 5 4 Ankyrin repeats (many copies) PSI PF01437.23 T194655_1 - 1.1e-06 28.9 3.4 1.1e-06 28.9 3.4 3.3 3 0 0 3 3 3 1 Plexin repeat Ig_3 PF13927.4 T194655_1 - 0.0064 16.9 0.0 0.025 15.1 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T194655_1 - 0.027 14.4 0.0 0.049 13.6 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain Sema PF01403.17 T194655_2 - 5.3e-145 483.3 0.0 6.6e-145 483.0 0.0 1.1 1 0 0 1 1 1 1 Sema domain Ank_4 PF13637.4 T194655_2 - 3.8e-23 81.4 6.0 1e-10 41.8 0.6 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 T194655_2 - 1.3e-21 76.9 0.1 6.3e-11 42.6 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 T194655_2 - 5.7e-17 61.2 3.7 7.6e-06 26.0 0.1 4.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.4 T194655_2 - 1.5e-15 56.9 1.0 3.6e-06 27.1 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 T194655_2 - 9.5e-15 53.1 0.5 0.00019 21.5 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat RhoGEF PF00621.18 T219417_1 - 3e-46 157.8 0.1 1.4e-45 155.6 0.1 2.1 2 0 0 2 2 2 1 RhoGEF domain DEP PF00610.19 T219417_1 - 2.3e-42 142.8 0.0 1.2e-20 73.2 0.0 2.7 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ PF00595.22 T219417_1 - 1.3e-07 31.7 0.0 0.00034 20.8 0.0 2.4 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PH PF00169.27 T219417_1 - 0.00011 22.5 0.2 0.00033 21.0 0.2 1.8 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 T219417_1 - 0.00061 19.9 0.4 0.0018 18.4 0.4 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PDZ_2 PF13180.4 T219417_1 - 0.023 14.8 0.0 8.1 6.7 0.0 2.7 2 0 0 2 2 2 0 PDZ domain LRR_9 PF14580.4 T143090_3 - 1.7e-14 53.6 7.7 1.7e-14 53.6 7.7 2.5 2 1 1 3 3 3 1 Leucine-rich repeat LRR_4 PF12799.5 T143090_3 - 6.7e-12 45.2 22.8 1.6e-05 25.0 4.5 3.9 2 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T143090_3 - 8e-08 31.8 19.0 3.6e-06 26.5 8.1 3.0 1 1 2 3 3 3 3 Leucine rich repeat Acyltransferase PF01553.19 T194391_1 - 0.003 17.1 0.0 0.0071 15.8 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase WH1 PF00568.21 T177307_3 - 3.1e-38 130.0 0.0 4.6e-38 129.4 0.0 1.2 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 T177307_3 - 9.2e-16 57.0 8.6 1.4e-15 56.4 8.6 1.3 1 0 0 1 1 1 1 VASP tetramerisation domain ASD2 PF08687.9 T177307_3 - 0.015 14.8 2.6 0.022 14.3 2.6 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Ran_BP1 PF00638.16 T177307_3 - 0.045 13.9 0.0 0.077 13.1 0.0 1.3 1 0 0 1 1 1 0 RanBP1 domain fn3 PF00041.19 T016695_2 - 3e-05 24.1 0.2 4.7e-05 23.5 0.2 1.3 1 0 0 1 1 1 1 Fibronectin type III domain PBP PF01161.18 T016695_2 - 0.1 12.7 0.2 0.32 11.2 0.1 1.7 2 0 0 2 2 2 0 Phosphatidylethanolamine-binding protein AMP-binding PF00501.26 T228385_1 - 1e-92 310.8 0.2 4.4e-65 219.8 0.1 2.2 2 0 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.9 T228385_1 - 7.1e-35 120.0 1.0 1.3e-34 119.2 1.0 1.4 1 0 0 1 1 1 1 DMAP1-binding Domain Transposase_22 PF02994.12 T228385_1 - 2.7e-06 26.4 0.3 4.2e-06 25.7 0.3 1.1 1 0 0 1 1 1 1 L1 transposable element GvpG PF05120.10 T228385_1 - 0.013 15.3 0.1 0.024 14.5 0.1 1.3 1 0 0 1 1 1 0 Gas vesicle protein G PACT_coil_coil PF10495.7 T228385_3 - 6.8e-24 84.1 0.2 6.8e-24 84.1 0.2 4.5 4 0 0 4 4 4 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein bZIP_1 PF00170.19 T021504_1 - 1.3e-12 47.5 11.9 1.3e-12 47.5 11.9 1.9 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.13 T021504_1 - 4e-09 36.3 9.7 1.2e-08 34.7 9.7 1.8 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 T021504_1 - 8.8e-05 22.8 10.5 0.00017 21.9 10.5 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.10 T021504_1 - 0.0025 18.1 2.8 0.0062 16.8 2.8 1.6 1 0 0 1 1 1 1 Cell division protein ZapB IncA PF04156.12 T021504_1 - 0.049 13.3 4.3 0.096 12.3 4.3 1.4 1 0 0 1 1 1 0 IncA protein DUF4407 PF14362.4 T021504_1 - 0.099 11.8 0.8 0.15 11.3 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EMP24_GP25L PF01105.22 T021504_1 - 0.39 10.5 1.2 0.61 9.9 1.2 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD KASH_CCD PF14662.4 T021504_1 - 0.62 9.8 8.8 0.93 9.2 8.8 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH HAUS-augmin3 PF14932.4 T021504_1 - 0.64 9.4 5.8 1 8.7 5.8 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 JMY PF15871.3 T021504_1 - 0.84 8.7 3.9 1.3 8.1 3.9 1.1 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein APG6 PF04111.10 T021504_1 - 0.89 8.7 4.5 1.4 8.2 4.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Jnk-SapK_ap_N PF09744.7 T021504_1 - 1.4 9.0 8.4 2.4 8.2 8.4 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ADIP PF11559.6 T021504_1 - 3.8 7.5 14.4 6.3 6.7 14.4 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF724 PF05266.12 T021504_1 - 5.1 6.7 6.2 8.7 6.0 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) NDT80_PhoG PF05224.10 T082013_1 - 4.9e-12 46.3 0.6 2.1e-11 44.3 0.6 1.8 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family MRF_C2 PF13888.4 T082013_3 - 1.5e-49 167.2 1.3 3.1e-49 166.3 1.3 1.5 1 0 0 1 1 1 1 Myelin gene regulatory factor C-terminal domain 2 MRF_C1 PF13887.4 T082013_3 - 9e-21 72.6 0.7 1.9e-20 71.6 0.7 1.6 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 Peptidase_S74 PF13884.4 T082013_3 - 3e-14 52.9 0.1 6.2e-14 51.9 0.1 1.6 1 0 0 1 1 1 1 Chaperone of endosialidase Sec2p PF06428.9 T082013_3 - 3.9e-08 33.0 6.4 3.9e-08 33.0 6.4 2.1 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p DUF4699 PF15770.3 T263369_3 - 6.9e-124 413.5 1.4 9.3e-124 413.1 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4699) zf-H2C2_2 PF13465.4 T167863_2 - 4.6e-57 187.9 52.2 1.8e-09 37.4 2.4 8.8 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 T167863_2 - 9.7e-40 132.7 50.9 2.7e-06 27.4 1.0 8.0 7 0 0 7 7 7 7 Zinc finger, C2H2 type KRAB PF01352.25 T167863_2 - 5.9e-25 86.5 2.0 7.3e-25 86.3 0.3 2.0 2 0 0 2 2 2 1 KRAB box zf-C2H2_4 PF13894.4 T167863_2 - 2.8e-23 80.5 47.9 0.0062 17.1 3.8 8.4 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T167863_2 - 4e-19 68.0 41.7 6.4e-05 22.7 0.5 7.9 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T167863_2 - 9.2e-09 35.3 36.1 0.052 13.8 0.4 7.7 7 0 0 7 7 7 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T167863_2 - 0.0099 15.8 33.4 0.066 13.2 3.6 5.2 1 1 6 7 7 7 5 Zinc ribbon domain zf-C2H2_11 PF16622.3 T167863_2 - 0.043 13.4 34.1 0.21 11.2 0.0 7.8 8 0 0 8 8 8 0 zinc-finger C2H2-type XPA_N PF01286.16 T167863_2 - 0.11 12.4 28.7 10 6.1 0.2 7.5 7 0 0 7 7 7 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 T167863_2 - 0.22 12.2 26.4 1.1 10.0 1.7 4.1 1 1 1 3 3 3 0 zinc-ribbon family K_channel_TID PF07941.9 T081608_1 - 7.5 7.0 6.6 12 6.3 6.6 1.2 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain TIP120 PF08623.8 T081608_3 - 4.1e-65 218.5 8.9 1.5e-64 216.7 0.7 4.2 4 1 1 5 5 5 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.4 T081608_3 - 1.9e-18 66.5 0.3 0.0032 17.7 0.0 8.6 6 3 3 9 9 9 4 HEAT repeats HEAT_EZ PF13513.4 T081608_3 - 5.6e-16 58.5 5.0 0.0048 17.2 0.1 9.9 10 1 2 12 12 11 1 HEAT-like repeat HEAT PF02985.20 T081608_3 - 1e-14 53.2 10.9 0.28 11.4 0.0 10.2 10 0 0 10 10 9 3 HEAT repeat UME PF08064.11 T081608_3 - 2.6e-09 36.8 8.0 0.036 13.9 0.1 6.8 6 1 0 7 7 7 2 UME (NUC010) domain CLASP_N PF12348.6 T081608_3 - 1.9e-06 27.5 0.4 1.1 8.7 0.0 4.9 5 0 0 5 5 5 2 CLASP N terminal Vac14_Fab1_bd PF12755.5 T081608_3 - 2.3e-06 27.9 5.7 0.023 15.2 0.1 6.0 6 1 1 7 7 6 1 Vacuolar 14 Fab1-binding region Telomere_reg-2 PF10193.7 T081608_3 - 4.3e-06 27.0 2.2 1.7 8.9 0.0 5.7 5 0 0 5 5 5 1 Telomere length regulation protein DUF3385 PF11865.6 T081608_3 - 1e-05 25.3 2.2 0.0026 17.5 0.1 4.4 4 0 0 4 4 4 1 Domain of unknown function (DUF3385) Cnd1 PF12717.5 T081608_3 - 4.6e-05 23.3 15.4 0.14 12.0 0.5 6.6 7 1 1 8 8 7 2 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.6 T081608_3 - 5.8e-05 22.3 19.0 0.00015 20.9 0.6 5.9 6 1 1 7 7 7 2 RNAPII transcription regulator C-terminal RTP1_C1 PF10363.7 T081608_3 - 0.00014 21.9 6.2 3.7 7.6 0.1 6.0 6 1 1 7 7 7 2 Required for nuclear transport of RNA pol II C-terminus 1 VHS PF00790.17 T081608_3 - 0.065 13.0 0.5 1.3 8.8 0.1 3.0 3 0 0 3 3 3 0 VHS domain V-ATPase_H_C PF11698.6 T081608_3 - 1.3 9.0 9.7 1.3 9.0 0.8 4.5 5 0 0 5 5 5 0 V-ATPase subunit H CEBP1_N PF16368.3 T120874_2 - 5.8e-156 518.6 11.4 8.8e-156 518.0 11.4 1.3 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein 1 N-terminus RRM_7 PF16367.3 T120874_2 - 2e-34 117.4 0.0 4.6e-34 116.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif CEBP_ZZ PF16366.3 T120874_2 - 1.6e-23 82.5 7.3 1.6e-23 82.5 7.3 2.3 3 0 0 3 3 3 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.20 T120874_2 - 7.2e-07 28.8 0.0 0.0075 15.9 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) IL8 PF00048.18 T133142_3 - 4.8e-16 58.5 0.2 1.2e-15 57.3 0.2 1.7 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like LIM_bind PF01803.14 T261876_2 - 1.2e-53 182.0 10.4 2.5e-43 148.2 0.5 2.4 2 1 1 3 3 3 2 LIM-domain binding protein Lipase_GDSL PF00657.20 T186981_2 - 2.2e-78 262.7 0.0 1.5e-27 96.7 0.0 3.8 4 0 0 4 4 4 3 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.4 T186981_2 - 2.8e-22 79.9 4.8 4.8e-06 27.0 0.8 4.6 3 3 0 3 3 3 3 GDSL-like Lipase/Acylhydrolase family IL17R_fnIII_D2 PF16578.3 T186981_2 - 0.033 14.6 5.8 38 4.7 0.0 5.1 5 0 0 5 5 5 0 Interleukin 17 receptor D EBP PF05241.10 T374373_1 - 2.5e-55 186.5 9.4 2.5e-55 186.5 9.4 1.5 2 0 0 2 2 2 1 Emopamil binding protein MBOAT PF03062.17 T374373_2 - 2.3e-17 63.2 11.7 4.2e-17 62.4 11.7 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family FUSC_2 PF13515.4 T374373_2 - 0.1 12.6 5.5 5.4 7.1 0.8 2.7 2 0 0 2 2 2 0 Fusaric acid resistance protein-like TMCO5 PF14992.4 T075740_2 - 9.2e-23 81.1 21.7 3.8e-20 72.5 4.1 2.5 3 0 0 3 3 3 2 TMCO5 family PAS_11 PF14598.4 T075740_3 - 7.9e-26 90.3 0.0 8.3e-21 74.1 0.0 2.3 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.10 T075740_3 - 6e-20 71.2 0.0 1.2e-13 51.0 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 T075740_3 - 5.3e-18 64.9 0.0 8.7e-09 35.2 0.0 2.3 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 T075740_3 - 1.1e-13 50.8 1.7 1.1e-13 50.8 1.7 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 T075740_3 - 6.1e-10 39.1 0.0 3e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 PAS domain TMCO5 PF14992.4 T075740_3 - 4.9e-05 22.9 0.1 8.5e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 TMCO5 family PAS_4 PF08448.8 T075740_3 - 0.00019 21.5 0.0 0.11 12.6 0.0 2.7 2 0 0 2 2 2 2 PAS fold Lectin_C PF00059.19 T357773_1 - 1.9e-07 31.7 0.4 3.8e-07 30.7 0.4 1.5 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 T357773_1 - 0.00014 21.4 1.5 0.00068 19.2 0.2 2.2 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like DMPK_coil PF08826.8 T357773_1 - 0.0055 16.7 12.4 0.0055 16.7 12.4 2.0 2 0 0 2 2 2 1 DMPK coiled coil domain like IncA PF04156.12 T357773_1 - 0.0059 16.3 23.0 0.018 14.7 23.1 1.6 1 1 1 2 2 2 1 IncA protein Exonuc_VII_L PF02601.13 T357773_1 - 0.0085 15.6 3.1 0.011 15.2 3.1 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit DUF1664 PF07889.10 T357773_1 - 0.026 14.4 3.5 0.053 13.4 3.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3450 PF11932.6 T357773_1 - 0.037 13.2 10.8 0.064 12.4 10.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF342 PF03961.11 T357773_1 - 0.6 8.5 4.0 0.87 8.0 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TMPIT PF07851.11 T357773_1 - 1.4 7.9 4.5 2.3 7.3 4.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein Occludin_ELL PF07303.11 T357773_1 - 1.8 9.2 8.6 24 5.6 5.1 2.3 2 0 0 2 2 2 0 Occludin homology domain HOOK PF05622.10 T357773_1 - 3 5.7 18.0 4.2 5.3 18.0 1.1 1 0 0 1 1 1 0 HOOK protein WD40 PF00400.30 T108727_1 - 2.2e-60 199.0 89.9 2e-05 25.1 0.2 26.3 29 0 0 29 29 29 15 WD domain, G-beta repeat HELP PF03451.12 T108727_1 - 2.1e-56 187.5 1.4 1.7e-18 66.1 0.0 3.4 3 0 0 3 3 3 3 HELP motif ANAPC4_WD40 PF12894.5 T108727_1 - 9.5e-34 115.4 3.8 1.7e-07 31.3 0.0 12.3 8 3 4 13 13 13 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T108727_1 - 8.9e-07 28.0 1.8 0.012 14.4 0.0 5.7 4 3 4 8 8 8 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.14 T108727_1 - 0.014 13.8 8.1 0.99 7.7 0.0 5.4 6 1 1 7 7 7 0 Cytochrome D1 heme domain PD40 PF07676.10 T108727_1 - 0.091 12.6 0.0 1.2e+02 2.7 0.0 4.4 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat zf-RING_2 PF13639.4 T297754_2 - 1e-05 25.6 8.8 1e-05 25.6 8.8 3.4 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 T297754_2 - 0.00018 21.2 10.0 0.00018 21.2 10.0 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 T297754_2 - 1.5 8.9 10.1 5.8 7.0 10.1 2.2 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 T297754_2 - 3.9 7.3 20.4 0.016 14.9 10.1 2.6 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.19 T297754_2 - 4.9 7.2 9.7 15 5.7 9.7 1.8 1 0 0 1 1 1 0 FYVE zinc finger Metal_resist PF13801.4 T249100_3 - 0.0023 18.0 1.7 0.0023 18.0 1.7 9.2 9 0 0 9 9 9 2 Heavy-metal resistance HALZ PF02183.16 T249100_3 - 0.0026 17.8 2.3 0.0026 17.8 2.3 29.5 30 2 2 32 32 32 8 Homeobox associated leucine zipper Hist_deacetyl PF00850.17 T236292_2 - 2.9e-68 230.5 0.4 6.9e-68 229.2 0.2 1.7 2 0 0 2 2 2 1 Histone deacetylase domain Spc97_Spc98 PF04130.11 T236292_2 - 2e-41 142.3 0.2 2.8e-41 141.8 0.2 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Pkinase PF00069.23 T236292_3 - 3.1e-66 223.3 0.0 3.9e-66 223.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Spc97_Spc98 PF04130.11 T236292_3 - 1.2e-48 166.1 0.9 1.6e-48 165.7 0.9 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Pkinase_Tyr PF07714.15 T236292_3 - 6e-28 97.7 0.0 9.1e-28 97.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 T236292_3 - 0.012 15.4 0.0 0.012 15.4 0.0 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.12 T236292_3 - 0.049 12.8 0.0 0.089 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 T236292_3 - 0.12 11.5 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Kinase-like 2OG-FeII_Oxy_2 PF13532.4 T143180_1 - 1.6e-08 34.9 0.0 3.1e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MyTH4 PF00784.15 T143180_2 - 3.4e-52 175.3 0.2 1.5e-24 86.4 0.1 2.6 2 0 0 2 2 2 2 MyTH4 domain SH3_2 PF07653.15 T143180_2 - 1.3e-15 56.7 0.0 2.6e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PPP1R26_N PF15740.3 T368752_3 - 0 1245.1 29.2 0 1244.8 29.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 1 regulatory subunit 26 N-terminus DEAD PF00270.27 T154571_3 - 2.5e-21 76.1 0.0 4.9e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T154571_3 - 4.3e-17 62.4 0.0 1.5e-12 47.7 0.0 2.3 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.13 T154571_3 - 1.1e-05 25.4 0.0 1.7e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit MTD PF01993.16 T154571_3 - 0.051 12.8 0.1 0.14 11.4 0.0 1.7 2 0 0 2 2 2 0 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase AAA_22 PF13401.4 T154571_3 - 0.066 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cyclin_N PF00134.21 T147954_1 - 8.7e-08 31.9 1.6 0.00031 20.4 0.4 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain Mito_carr PF00153.25 T154303_3 - 1.3e-65 217.2 0.7 1.3e-21 76.2 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2043 PF09740.7 T259360_2 - 3.3e-38 130.5 0.1 3.3e-38 130.5 0.1 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2043) Homeobox PF00046.27 T192152_3 - 1.2e-18 66.5 7.0 2.3e-18 65.6 7.0 1.5 1 0 0 1 1 1 1 Homeobox domain Tim44 PF04280.13 T205568_3 - 0.12 12.3 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Tim44-like domain AA_permease_2 PF13520.4 T135057_1 - 2e-43 148.7 20.6 3e-43 148.1 20.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 T135057_1 - 1.2e-16 60.3 18.5 1.9e-16 59.6 18.5 1.2 1 0 0 1 1 1 1 Amino acid permease DUF2304 PF10066.7 T135057_1 - 9 6.5 7.6 1.2 9.3 1.8 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) AA_permease_2 PF13520.4 T135057_2 - 2.4e-14 52.9 13.6 3.6e-14 52.3 13.6 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 T135057_2 - 0.0025 16.3 12.3 0.0041 15.6 12.3 1.2 1 0 0 1 1 1 1 Amino acid permease Trp_Tyr_perm PF03222.11 T135057_2 - 0.054 12.4 6.1 0.077 11.9 6.1 1.1 1 0 0 1 1 1 0 Tryptophan/tyrosine permease family ubiquitin PF00240.21 T148496_2 - 8e-09 35.0 0.0 1.2e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family MAP17 PF15807.3 T028109_2 - 0.093 12.8 0.2 0.22 11.6 0.2 1.5 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 C2 PF00168.28 T028109_3 - 1e-52 176.6 0.2 4.7e-27 94.2 0.0 2.4 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.4 T028109_3 - 0.0053 16.2 0.0 3.8 6.9 0.0 2.2 2 0 0 2 2 2 2 CEP76 C2 domain DOCK-C2 PF14429.4 T028109_3 - 0.034 13.9 0.1 6.1 6.5 0.0 2.2 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins Aft1_OSA PF11785.6 T335871_2 - 0.052 13.9 0.9 0.12 12.7 0.9 1.5 1 0 0 1 1 1 0 Aft1 osmotic stress response (OSM) domain RhoGAP PF00620.25 T233387_1 - 2e-43 147.7 0.0 3.2e-43 147.0 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain BAR PF03114.16 T233387_1 - 1.2e-34 119.9 6.3 1.6e-34 119.5 6.3 1.1 1 0 0 1 1 1 1 BAR domain DUF2046 PF09755.7 T233387_1 - 0.0083 15.3 1.7 0.013 14.6 1.7 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) BAR_3 PF16746.3 T233387_1 - 0.2 11.2 1.2 0.38 10.3 1.2 1.4 1 0 0 1 1 1 0 BAR domain of APPL family BAR_2 PF10455.7 T233387_1 - 0.37 9.8 2.0 0.52 9.3 2.0 1.1 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking VHS PF00790.17 T233387_2 - 6.5e-39 132.9 0.3 2.5e-38 131.0 0.0 1.9 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.18 T233387_2 - 7.8e-28 96.9 0.0 1.6e-27 95.9 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.12 T233387_2 - 2.3e-23 82.2 1.0 2.3e-23 82.2 1.0 2.1 2 0 0 2 2 2 1 GAT domain AP3B1_C PF14796.4 T233387_2 - 0.13 12.4 0.2 0.25 11.4 0.2 1.4 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Ferritin PF00210.22 T233387_2 - 0.26 11.1 1.0 0.49 10.2 0.7 1.5 2 0 0 2 2 2 0 Ferritin-like domain DUF1313 PF07011.9 T233387_2 - 0.37 10.6 3.3 2.5 7.9 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1313) DUF3450 PF11932.6 T233387_2 - 4.3 6.4 4.7 7 5.7 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) zf-H2C2_2 PF13465.4 T174709_1 - 7.4e-84 272.6 106.0 2.8e-08 33.7 0.4 14.8 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 T174709_1 - 2.2e-51 169.4 106.5 0.00012 22.2 3.6 14.4 14 0 0 14 14 14 12 Zinc finger, C2H2 type KRAB PF01352.25 T174709_1 - 9.5e-23 79.5 1.6 1.9e-22 78.5 1.6 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T174709_1 - 3.1e-22 77.2 102.1 0.037 14.7 0.9 14.5 14 0 0 14 14 14 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T174709_1 - 1.6e-15 56.5 83.7 0.034 14.0 0.9 13.8 13 0 0 13 13 13 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T174709_1 - 2.1e-09 37.2 81.1 0.0056 16.6 3.7 9.2 2 1 9 12 12 12 10 Zinc ribbon domain C1_4 PF07975.10 T174709_1 - 0.0019 18.3 62.1 0.65 10.2 6.9 9.3 3 2 6 10 10 10 3 TFIIH C1-like domain DUF3268 PF11672.6 T174709_1 - 3.4 7.9 43.8 3.8 7.7 2.2 7.0 5 1 2 7 7 7 0 zinc-finger-containing domain Baculo_LEF-11 PF06385.10 T174709_2 - 0.46 10.9 12.8 27 5.2 0.0 5.1 4 1 0 5 5 5 0 Baculovirus LEF-11 protein Xlink PF00193.15 T054754_2 - 2.8e-18 65.9 0.0 7.2e-18 64.6 0.0 1.7 1 0 0 1 1 1 1 Extracellular link domain MRVI1 PF05781.10 T054754_3 - 2.5e-211 702.9 5.6 3.3e-211 702.5 5.6 1.1 1 0 0 1 1 1 1 MRVI1 protein DUF1725 PF08333.9 T054754_3 - 6.1e-08 32.0 0.7 1.3e-07 30.9 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Yae1_N PF09811.7 T054754_3 - 0.59 9.8 3.3 0.53 9.9 0.3 2.2 2 0 0 2 2 2 0 Essential protein Yae1, N terminal WD40_4 PF16300.3 T144910_1 - 8.2e-21 73.5 0.2 1.7e-20 72.5 0.2 1.6 1 0 0 1 1 1 1 Type of WD40 repeat DSPc PF00782.18 T144910_2 - 7.6e-33 113.0 0.0 1.4e-32 112.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.9 T144910_2 - 4.3e-10 39.2 5.1 7.8e-10 38.4 5.1 1.5 1 0 0 1 1 1 1 DEK C terminal domain DUF1899 PF08953.9 T144910_3 - 6.7e-28 96.2 0.0 1.3e-27 95.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.30 T144910_3 - 4.3e-07 30.4 1.3 0.026 15.3 0.2 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T144910_3 - 1.6e-05 25.0 0.1 0.0041 17.2 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain TM140 PF14985.4 T333742_2 - 3.6e-93 310.0 7.4 4.8e-93 309.6 7.4 1.1 1 0 0 1 1 1 1 TM140 protein family TMEM37 PF15108.4 T333742_2 - 0.0055 16.5 1.7 0.0097 15.7 1.7 1.4 1 0 0 1 1 1 1 Voltage-dependent calcium channel gamma-like subunit protein family ODV-E18 PF10717.7 T333742_2 - 0.6 9.9 2.0 7.5 6.4 0.1 2.6 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 TACC PF05010.12 T049801_2 - 8.3e-84 280.2 34.2 1.2e-83 279.7 34.2 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) Skp1_POZ PF03931.13 T049801_2 - 0.061 13.4 0.4 0.13 12.3 0.4 1.5 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain SLC35F PF06027.10 T310405_2 - 8.7e-148 491.5 23.4 1.3e-147 491.0 23.4 1.2 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.18 T310405_2 - 1.5e-11 44.5 31.2 8.2e-07 29.1 13.2 2.4 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.8 T310405_2 - 1.2e-09 37.4 6.3 1.2e-09 37.4 6.3 1.6 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like Mito_carr PF00153.25 T084767_1 - 3.9e-47 158.0 5.0 3.5e-18 65.2 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein KH_1 PF00013.27 T013588_1 - 1.7e-68 226.3 14.9 4.5e-18 64.7 0.1 4.2 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 T013588_1 - 1.1e-21 76.3 9.9 7.6e-06 25.5 0.0 4.3 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.8 T013588_1 - 1.3e-11 43.6 21.8 7.3e-07 28.4 5.3 3.7 3 0 0 3 3 3 2 Domain of unknown function (DUF1897) KH_4 PF13083.4 T013588_1 - 2.9e-07 30.1 11.8 0.081 12.7 0.1 4.2 4 0 0 4 4 4 3 KH domain KH_5 PF13184.4 T013588_1 - 0.11 12.4 10.0 9.7 6.2 0.1 4.1 4 0 0 4 4 4 0 NusA-like KH domain Secretin_N PF03958.15 T013588_1 - 0.14 12.5 5.5 0.19 12.0 0.4 3.0 2 2 1 3 3 3 0 Bacterial type II/III secretion system short domain MAJIN PF15077.4 T060943_2 - 9.3e-15 55.0 0.4 1.4e-14 54.5 0.4 1.2 1 0 0 1 1 1 1 Membrane-anchored junction protein Hormone_6 PF00236.16 T060943_2 - 0.0021 17.9 5.6 0.0043 16.9 5.6 1.4 1 0 0 1 1 1 1 Glycoprotein hormone Cys_knot PF00007.20 T060943_2 - 0.026 14.7 8.7 0.046 13.9 8.7 1.4 1 0 0 1 1 1 0 Cystine-knot domain MAJIN PF15077.4 T060943_3 - 5e-42 144.3 1.1 2.7e-30 105.9 0.3 2.1 1 1 1 2 2 2 2 Membrane-anchored junction protein G-gamma PF00631.20 T060185_1 - 7.3e-17 61.0 0.1 1.7e-16 59.8 0.1 1.7 1 0 0 1 1 1 1 GGL domain UPAR_LY6_2 PF16975.3 T200772_2 - 6.8e-54 180.4 17.8 1.1e-53 179.7 17.8 1.3 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 Glyco_transf_18 PF15024.4 T199835_3 - 3.3e-265 880.9 1.7 4e-265 880.6 1.7 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 DUF4525 PF15027.4 T199835_3 - 2.2e-62 208.7 0.1 3.7e-62 208.0 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4525) FoP_duplication PF13865.4 T021404_2 - 1.2e-21 76.9 9.3 1.2e-21 76.9 9.3 4.5 3 1 1 4 4 4 2 C-terminal duplication domain of Friend of PRMT1 S_100 PF01023.17 T021404_3 - 9.8e-20 69.9 1.2 1.6e-19 69.2 1.2 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 T021404_3 - 9e-06 25.9 0.4 1.6e-05 25.2 0.4 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 T021404_3 - 6e-05 22.2 0.3 0.00013 21.1 0.1 1.7 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 T021404_3 - 0.019 14.6 0.1 0.034 13.8 0.1 1.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.4 T021404_3 - 0.021 14.2 2.1 0.03 13.7 0.1 2.0 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.4 T021404_3 - 0.13 12.2 0.3 3.1 7.8 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain DUF3504 PF12012.6 T364893_3 - 8.5e-19 67.9 0.0 1.9e-18 66.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) RhoGAP PF00620.25 T171044_2 - 8.9e-49 165.1 0.0 1.7e-48 164.2 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain 7tm_1 PF00001.19 T171044_2 - 1.5e-30 106.2 9.2 2.4e-30 105.6 9.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T171044_2 - 1.4e-07 31.1 3.7 1.9e-07 30.6 3.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx C1_1 PF00130.20 T171044_2 - 0.0001 22.0 7.2 0.0001 22.0 7.2 2.6 3 0 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) 7tm_4 PF13853.4 T171044_2 - 0.00043 20.0 4.7 0.00047 19.8 3.1 1.7 2 0 0 2 2 2 1 Olfactory receptor bZIP_1 PF00170.19 T060963_1 - 1.6e-09 37.6 9.3 2.6e-09 36.9 9.3 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 T060963_1 - 1.3e-05 25.0 13.5 2e-05 24.4 13.5 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 T060963_1 - 0.00053 20.3 8.1 0.0009 19.6 8.1 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor HALZ PF02183.16 T060963_1 - 0.00077 19.5 3.8 0.0014 18.6 3.8 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper HAP1_N PF04849.11 T060963_1 - 0.0074 15.4 3.1 0.01 14.9 3.1 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region DUF3287 PF11690.6 T060963_1 - 0.98 9.0 3.2 1.7 8.3 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) ubiquitin PF00240.21 T142547_2 - 2.9e-68 225.4 4.2 2.5e-33 113.5 0.3 2.2 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.6 T142547_2 - 2.3e-32 110.5 4.6 2.1e-15 56.2 0.4 2.2 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 T142547_2 - 1.4e-11 44.5 1.0 0.00014 22.1 0.1 2.6 2 0 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 T142547_2 - 2.6e-05 24.2 0.4 0.32 11.0 0.1 2.5 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 T142547_2 - 0.00084 19.7 0.0 2.4 8.6 0.0 2.3 1 1 0 2 2 2 2 DUF2407 ubiquitin-like domain KH_1 PF00013.27 T361222_2 - 3.2e-42 142.0 13.9 1.3e-19 69.6 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 T361222_2 - 7.4e-27 93.2 8.0 6e-26 90.3 9.8 1.6 2 0 0 2 2 2 1 ROKNT (NUC014) domain KH_2 PF07650.15 T361222_2 - 1.8e-11 43.6 11.1 0.0018 17.9 0.5 3.7 2 1 0 3 3 3 3 KH domain KH_4 PF13083.4 T361222_2 - 1.7e-07 30.9 6.0 1.5e-05 24.6 0.0 3.2 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 T361222_2 - 0.00041 20.2 3.2 0.71 9.9 0.2 3.4 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.3 T361222_2 - 0.13 12.1 0.0 3.6 7.5 0.0 2.4 2 0 0 2 2 2 0 KH-like RNA-binding domain DJ-1_PfpI PF01965.22 T361222_2 - 0.19 11.4 0.0 0.41 10.3 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family Pyr_redox_2 PF07992.12 T330978_2 - 3.2e-66 223.4 6.6 3.2e-66 223.4 6.6 1.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 T330978_2 - 1.8e-41 140.7 0.0 3.9e-41 139.6 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 T330978_2 - 8.9e-17 61.3 5.0 1.7e-15 57.2 1.4 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 T330978_2 - 2.5e-08 33.6 0.1 2.5e-08 33.6 0.1 2.2 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 T330978_2 - 4.7e-08 32.4 0.2 5.4e-06 25.6 0.2 2.4 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.4 T330978_2 - 8.8e-08 31.6 2.2 8.4e-07 28.4 2.2 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 T330978_2 - 6.9e-07 29.3 2.4 0.00012 22.2 0.1 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.20 T330978_2 - 8.3e-06 25.0 2.3 8.3e-06 25.0 2.3 2.3 2 1 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.12 T330978_2 - 3.4e-05 22.6 3.6 0.0023 16.5 0.5 2.8 3 0 0 3 3 3 2 HI0933-like protein AlaDh_PNT_C PF01262.19 T330978_2 - 0.00029 20.1 3.8 0.1 11.7 0.5 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 T330978_2 - 0.0038 16.4 0.0 0.0076 15.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family K_oxygenase PF13434.4 T330978_2 - 0.0043 16.1 0.4 1.9 7.4 0.3 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.17 T330978_2 - 0.0058 15.8 4.2 0.039 13.1 0.1 2.9 3 0 0 3 3 3 1 FAD binding domain UDPG_MGDP_dh_N PF03721.12 T330978_2 - 0.53 9.7 3.3 6.7 6.1 0.2 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.16 T330978_2 - 2.3 7.9 4.1 6.6 6.4 0.6 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ABC2_membrane_3 PF12698.5 T125435_3 - 2.9e-55 187.7 30.8 1.7e-34 119.3 4.9 2.6 2 1 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.25 T125435_3 - 1.6e-51 174.3 0.0 5.5e-28 98.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 T125435_3 - 4e-17 62.8 1.0 2.1e-05 24.4 0.0 4.1 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.4 T125435_3 - 7.8e-05 22.3 0.0 0.29 10.6 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.4 T125435_3 - 9.9e-05 22.8 1.6 0.008 16.6 0.0 2.5 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.14 T125435_3 - 0.0011 18.8 0.3 0.034 13.9 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 T125435_3 - 0.0011 18.5 0.9 0.056 13.0 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF4162 PF13732.4 T125435_3 - 0.0065 17.0 0.0 8.3 7.1 0.0 3.3 4 0 0 4 4 4 1 Domain of unknown function (DUF4162) AAA_22 PF13401.4 T125435_3 - 0.031 14.4 0.6 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.20 T125435_3 - 0.094 12.2 3.3 1.4 8.3 0.3 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_30 PF13604.4 T125435_3 - 0.094 12.3 0.1 2.3 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain 7tm_4 PF13853.4 T300125_2 - 3.7e-52 177.6 17.8 6.3e-52 176.9 17.8 1.3 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T300125_2 - 3e-27 95.4 23.2 6e-27 94.4 23.2 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) OTU PF02338.17 T113751_1 - 2e-23 83.1 0.0 3.2e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Anth_Ig PF05587.11 T041386_3 - 5.1e-38 129.5 1.7 1e-37 128.6 1.7 1.5 1 0 0 1 1 1 1 Anthrax receptor extracellular domain VWA PF00092.26 T041386_3 - 5.4e-07 29.9 0.1 7.7e-07 29.4 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain ABC_tran PF00005.25 T304030_2 - 4.1e-32 111.4 0.0 6.1e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.21 T304030_2 - 4.1e-31 108.5 0.6 5.5e-31 108.1 0.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.17 T304030_2 - 0.00015 21.1 0.0 0.01 15.2 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 T304030_2 - 0.0058 16.3 0.2 1.3 8.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 T304030_2 - 0.033 13.8 0.0 0.069 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF87 PF01935.15 T304030_2 - 0.047 13.6 0.1 0.074 12.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_16 PF13191.4 T304030_2 - 0.073 13.3 1.6 0.25 11.6 1.6 1.9 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.25 T304030_3 - 1.5e-19 70.7 0.0 2.3e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.21 T304030_3 - 7.8e-18 65.0 0.7 1.1e-17 64.5 0.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.17 T304030_3 - 0.0017 17.7 0.1 1.6 8.0 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain KAP_NTPase PF07693.12 T304030_3 - 0.11 11.6 0.1 0.15 11.2 0.1 1.1 1 0 0 1 1 1 0 KAP family P-loop domain MMR_HSR1 PF01926.21 T304030_3 - 0.18 11.8 0.1 0.29 11.1 0.1 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.4 T304030_3 - 0.18 11.4 0.8 0.78 9.4 0.1 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain SEEK1 PF15357.4 T300805_3 - 5.6e-99 328.1 8.8 5.6e-99 328.1 8.8 2.2 2 0 0 2 2 2 1 Psoriasis susceptibility 1 candidate 1 SH3_1 PF00018.26 T016971_1 - 1.5e-11 43.6 0.0 4.4e-11 42.1 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 T016971_1 - 1.5e-07 31.0 0.0 3.4e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T016971_1 - 3.2e-06 26.6 0.0 5.1e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 T016971_1 - 0.00047 20.2 0.1 0.00088 19.4 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain hSH3 PF14603.4 T016971_1 - 0.015 15.7 0.0 0.028 14.8 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain Ldl_recept_a PF00057.16 T168434_3 - 2.2e-86 283.6 141.8 4.4e-14 52.3 11.8 8.6 8 1 0 8 8 8 7 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 T168434_3 - 2.6e-67 222.9 5.7 1.1e-13 51.3 0.1 5.6 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 T168434_3 - 3.4e-21 75.1 40.6 2.6e-09 37.1 2.0 5.5 3 1 1 4 4 4 3 Coagulation Factor Xa inhibitory site cEGF PF12662.5 T168434_3 - 8e-14 51.1 8.6 6.6e-06 25.8 0.7 4.8 3 0 0 3 3 3 3 Complement Clr-like EGF-like EGF_CA PF07645.13 T168434_3 - 1.4e-07 31.5 7.6 1.4e-07 31.5 7.6 9.5 7 2 1 8 8 8 2 Calcium-binding EGF domain SGL PF08450.10 T168434_3 - 5.6e-06 26.0 0.4 0.13 11.7 0.1 2.7 2 1 1 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region EGF PF00008.25 T168434_3 - 0.003 17.7 20.1 0.0048 17.0 5.7 8.9 8 1 0 8 8 8 3 EGF-like domain WD40 PF00400.30 T101633_3 - 2.6e-18 65.9 17.1 0.0002 21.9 0.5 7.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T101633_3 - 1.7e-05 24.9 0.1 0.97 9.7 0.0 4.6 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.20 T061767_1 - 4.4e-32 109.6 0.1 3e-15 55.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 T061767_1 - 2.1e-06 27.2 0.2 0.0016 17.9 0.1 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 T061767_1 - 4.2e-06 26.5 3.0 4.2e-06 26.5 3.0 2.8 2 0 0 2 2 2 1 Zinc knuckle RRM_7 PF16367.3 T061767_1 - 0.0014 18.6 0.0 0.19 11.7 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.3 T061767_1 - 0.028 14.2 0.0 0.28 10.9 0.0 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif Spectrin PF00435.19 T061767_3 - 1.6e-261 848.0 167.3 1.4e-19 70.4 0.4 17.8 18 0 0 18 18 18 17 Spectrin repeat CH PF00307.29 T061767_3 - 2.3e-48 162.8 0.9 7.5e-24 83.9 0.1 2.8 2 0 0 2 2 2 2 Calponin homology (CH) domain PH_9 PF15410.4 T061767_3 - 6.5e-19 68.3 0.0 1.8e-18 66.9 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 T061767_3 - 2e-11 44.2 0.1 7.3e-11 42.4 0.0 2.1 2 0 0 2 2 2 1 PH domain CAMSAP_CH PF11971.6 T061767_3 - 7.9e-06 25.5 0.2 0.00016 21.3 0.1 2.4 2 0 0 2 2 2 1 CAMSAP CH domain GREB1 PF15782.3 T184689_1 - 0 1413.4 0.0 0 1413.1 0.0 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer GREB1 PF15782.3 T184689_2 - 0 1891.8 1.0 0 1891.4 1.0 1.1 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer DUF4564 PF15169.4 T157052_2 - 4.2e-06 26.5 0.0 5.7e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) DUF4564 PF15169.4 T157052_3 - 1.9e-68 229.7 0.0 2.6e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) Pkinase PF00069.23 T106722_2 - 7.7e-64 215.5 0.0 1.2e-63 214.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T106722_2 - 9.6e-63 211.7 0.0 1.3e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SH3_9 PF14604.4 T106722_2 - 9.2e-13 47.7 0.1 2.7e-12 46.2 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 T106722_2 - 1.2e-10 40.7 0.0 2.5e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 T106722_2 - 3.3e-10 39.4 0.0 6.6e-10 38.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain OmpH PF03938.12 T106722_2 - 1.3 8.9 5.0 2 8.2 5.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Ribosomal_60s PF00428.17 T106722_2 - 6.4 7.3 11.2 17 5.9 11.2 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Hormone_recep PF00104.28 T030464_2 - 7.2e-32 110.5 0.6 1.3e-31 109.7 0.6 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 T030464_2 - 7.3e-30 103.1 12.3 7.3e-30 103.1 12.3 2.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Y_phosphatase PF00102.25 T074547_3 - 9.9e-84 280.4 2.0 1.5e-83 279.9 2.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.19 T074547_3 - 3e-07 30.5 0.2 8.8e-07 29.1 0.1 1.7 2 0 0 2 2 2 1 Fibronectin type III domain Y_phosphatase3 PF13350.4 T074547_3 - 5.8e-05 23.0 0.0 9e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 T074547_3 - 0.00014 21.6 0.0 0.00028 20.6 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 T074547_3 - 0.0007 19.6 0.1 0.002 18.2 0.1 1.7 1 1 0 1 1 1 1 Inositol hexakisphosphate AAA_9 PF12781.5 T031607_1 - 5e-73 244.7 2.1 5e-73 244.7 2.1 2.3 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 MT PF12777.5 T031607_1 - 1.9e-36 125.7 8.9 2.9e-36 125.1 8.9 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor LolB PF03550.12 T031607_1 - 0.21 11.5 1.1 11 5.9 0.0 2.5 2 0 0 2 2 2 0 Outer membrane lipoprotein LolB Dynein_heavy PF03028.13 T031607_2 - 2e-173 578.2 0.1 1.7e-116 390.0 0.0 3.0 1 1 1 2 2 2 2 Dynein heavy chain and region D6 of dynein motor TSP_1 PF00090.17 T107070_1 - 3.2e-08 33.5 25.3 0.00034 20.7 6.8 4.1 3 0 0 3 3 3 3 Thrombospondin type 1 domain I-set PF07679.14 T107070_1 - 0.082 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_3 PF13927.4 T107070_1 - 0.093 13.2 0.9 0.18 12.3 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.14 T107070_2 - 2.7e-18 65.7 0.0 1.8e-14 53.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 T107070_2 - 3e-18 66.1 0.0 3.4e-14 53.1 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 T107070_2 - 6e-13 48.7 0.0 3e-09 36.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 T107070_2 - 8e-12 45.2 0.0 0.0035 17.4 0.0 3.3 2 1 1 3 3 3 3 Immunoglobulin V-set domain Ig_2 PF13895.4 T107070_2 - 1.2e-11 44.6 0.0 3.5e-10 39.9 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 T107070_2 - 0.0044 16.9 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 T107070_2 - 0.18 12.1 0.0 0.66 10.3 0.0 1.8 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Papilin_u7 PF16626.3 T107070_3 - 1.4e-43 147.2 21.4 3.1e-43 146.1 21.4 1.6 1 0 0 1 1 1 1 Linking region between Kunitz_BPTI and I-set on papilin Kunitz_BPTI PF00014.21 T107070_3 - 4.3e-17 62.0 7.7 1.1e-16 60.7 7.7 1.8 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain PLAC PF08686.9 T107070_3 - 1.7e-10 41.3 7.1 1.7e-10 41.3 7.1 3.7 5 0 0 5 5 5 1 PLAC (protease and lacunin) domain I-set PF07679.14 T107070_3 - 3.1e-06 27.0 0.0 0.0029 17.5 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.15 T107070_3 - 3.7e-05 23.7 0.1 0.011 15.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 T107070_3 - 6.7e-05 23.3 0.2 0.2 12.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 T107070_3 - 0.002 18.3 0.1 0.027 14.7 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 T107070_3 - 0.034 14.2 0.0 6.8 6.8 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin domain Band_7 PF01145.23 T342115_1 - 1.6e-11 44.4 0.0 2e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family PP2C PF00481.19 T188630_2 - 1.4e-80 270.5 0.0 1.8e-80 270.2 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.11 T188630_2 - 1.2e-31 108.8 0.1 2e-31 108.1 0.1 1.4 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain PP2C_2 PF13672.4 T188630_2 - 0.026 14.0 0.0 0.047 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein phosphatase 2C Tcf25 PF04910.12 T138932_1 - 1.3e-116 389.3 1.5 1.6e-116 388.9 1.5 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 FYVE_2 PF02318.14 T138932_2 - 0.49 10.5 5.1 1.3 9.1 5.1 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger FYVE PF01363.19 T138932_2 - 1.4 9.0 11.7 1.3 9.1 8.1 2.7 2 0 0 2 2 2 0 FYVE zinc finger KIND PF16474.3 T138932_3 - 1.6e-61 207.5 0.0 2.1e-61 207.0 0.0 1.2 1 0 0 1 1 1 1 Kinase non-catalytic C-lobe domain Mito_carr PF00153.25 T148606_2 - 4e-58 193.2 4.2 1.7e-19 69.4 0.3 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein SKI PF01202.20 T038586_2 - 1.2e-38 132.6 0.0 2.4e-38 131.6 0.0 1.5 1 0 0 1 1 1 1 Shikimate kinase Thr_synth_N PF14821.4 T038586_2 - 7.3e-13 48.4 0.0 1.7e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.23 T038586_2 - 1.3e-06 27.9 0.0 2.9e-06 26.8 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme AAA_18 PF13238.4 T038586_2 - 1.5e-06 28.6 0.0 4.2e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 T038586_2 - 0.00092 19.3 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.27 T038586_2 - 0.0011 19.3 0.0 0.0038 17.5 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.10 T038586_2 - 0.0027 16.9 0.0 0.0058 15.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.19 T038586_2 - 0.0075 15.5 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.15 T038586_2 - 0.027 14.1 0.0 0.082 12.5 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein Acid_PPase PF12689.5 T038586_2 - 0.074 12.8 0.0 0.25 11.0 0.0 1.9 1 0 0 1 1 1 0 Acid Phosphatase Cytidylate_kin PF02224.16 T038586_2 - 0.17 11.4 0.1 0.4 10.3 0.0 1.6 2 0 0 2 2 2 0 Cytidylate kinase P16-Arc PF04699.12 T366424_3 - 1.7e-54 184.2 0.0 2.3e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.10 T366424_3 - 0.072 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Dip2/Utp12 Family Hormone_recep PF00104.28 T346184_2 - 1.5e-39 135.6 0.1 2.1e-39 135.1 0.1 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 T346184_2 - 1.2e-08 35.2 4.3 2.5e-08 34.1 4.3 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) SH2 PF00017.22 T063429_1 - 1.6e-15 56.8 0.0 3.1e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SAM_1 PF00536.28 T063429_2 - 2.3e-08 34.2 0.1 5.2e-08 33.1 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T063429_2 - 2.7e-08 33.6 0.0 6e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Exo_endo_phos PF03372.21 T063429_2 - 0.083 13.0 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.25 T352629_1 - 0.0051 16.2 0.0 0.0087 15.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DENN PF02141.19 T352629_3 - 1.8e-36 125.7 1.0 3.7e-36 124.7 1.0 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.17 T352629_3 - 8.7e-05 22.3 1.4 8.7e-05 22.3 1.4 1.8 2 0 0 2 2 2 1 dDENN domain uDENN PF03456.16 T352629_3 - 0.00016 22.3 0.0 0.00057 20.5 0.0 1.9 1 0 0 1 1 1 1 uDENN domain DUF1725 PF08333.9 T352629_3 - 0.00019 20.9 0.8 0.0004 19.8 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) WD40 PF00400.30 T352629_3 - 0.00084 20.0 0.5 0.15 12.9 0.1 4.0 3 0 0 3 3 3 1 WD domain, G-beta repeat DUF2723 PF11028.6 T104921_3 - 2.2e-39 134.9 5.8 3.8e-39 134.2 5.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2723) P2X_receptor PF00864.17 T139789_3 - 6.7e-139 462.9 1.4 6.1e-135 449.9 0.1 2.1 1 1 1 2 2 2 2 ATP P2X receptor Clat_adaptor_s PF01217.18 T208663_1 - 1.2e-53 180.7 3.0 1.8e-53 180.1 3.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MFS_1 PF07690.14 T222128_1 - 1.3e-48 165.6 31.5 2.7e-48 164.6 31.5 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily CLTH PF10607.7 T222128_3 - 4.5e-32 110.8 4.5 6.4e-32 110.3 4.5 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.9 T222128_3 - 1.2e-09 37.7 0.7 3.1e-09 36.3 0.1 2.1 3 0 0 3 3 3 1 LisH CARD PF00619.19 T156061_2 - 4.3e-24 84.2 0.1 4.9e-23 80.8 0.0 2.6 2 0 0 2 2 2 1 Caspase recruitment domain Guanylate_kin PF00625.19 T156061_2 - 4.6e-05 23.0 0.0 0.00014 21.5 0.0 1.7 2 0 0 2 2 2 1 Guanylate kinase PDZ PF00595.22 T156061_2 - 0.008 16.4 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Y_phosphatase PF00102.25 T156061_2 - 0.15 11.4 1.1 0.27 10.6 1.1 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase MHC_I_3 PF16497.3 T022993_2 - 1.2e-93 312.0 4.4 1.6e-93 311.5 4.4 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 T022993_3 - 2.1e-10 40.8 0.0 3.5e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain BAG PF02179.14 T111118_2 - 3.4e-45 152.2 23.0 4.1e-15 55.8 0.2 4.8 5 0 0 5 5 5 4 BAG domain DUF327 PF03885.11 T111118_2 - 7.7 6.3 9.0 0.77 9.6 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF327) Peptidase_M8 PF01457.14 T101260_3 - 1.5e-27 96.3 0.0 1.3e-22 80.1 0.0 2.1 1 1 1 2 2 2 2 Leishmanolysin FKBP_C PF00254.26 T060583_1 - 5.8e-33 112.9 0.0 8.9e-33 112.4 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DnaJ PF00226.29 T060583_1 - 8.1e-19 67.4 0.0 1.3e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain VEGF_C PF14554.4 T060583_1 - 0.0037 17.2 20.6 0.0037 17.2 20.6 2.2 2 0 0 2 2 2 1 VEGF heparin-binding domain PDGF PF00341.15 T060583_2 - 8e-21 74.0 7.5 2e-20 72.8 7.5 1.7 1 0 0 1 1 1 1 PDGF/VEGF domain PAX PF00292.16 T047364_2 - 2.9e-74 246.8 0.5 4.7e-74 246.1 0.5 1.4 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 T047364_2 - 1.4e-54 182.9 15.1 3e-54 181.8 15.1 1.5 1 0 0 1 1 1 1 Paired-box protein 2 C terminal HTH_23 PF13384.4 T047364_2 - 0.00052 19.6 0.0 0.0014 18.2 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain Homeobox PF00046.27 T047364_2 - 0.042 13.5 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 Homeobox domain HTH_32 PF13565.4 T047364_2 - 0.11 13.0 0.0 0.11 13.0 0.0 4.8 4 1 1 5 5 5 0 Homeodomain-like domain Ras PF00071.20 T236716_2 - 1.2e-37 128.9 0.1 1.7e-37 128.4 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T236716_2 - 2.9e-33 114.5 0.0 4.6e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T236716_2 - 1.2e-09 37.7 0.0 1.9e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 T236716_2 - 1.2e-05 24.7 0.0 1.8e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 T236716_2 - 0.00015 21.2 0.1 0.0007 19.1 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 T236716_2 - 0.00031 20.7 0.0 0.0005 20.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.8 T236716_2 - 0.054 12.8 0.0 0.082 12.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TTL PF03133.13 T216053_1 - 4.8e-88 295.0 1.9 7.2e-88 294.4 1.9 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 T216053_1 - 2.5e-09 36.7 0.1 1.9e-05 23.9 0.0 3.3 3 1 0 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 T216053_1 - 0.0011 18.2 0.0 0.017 14.2 0.0 2.3 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp RimK PF08443.9 T216053_1 - 0.15 11.5 0.0 0.61 9.5 0.0 1.9 3 0 0 3 3 3 0 RimK-like ATP-grasp domain Paired_CXXCH_1 PF09699.8 T380387_3 - 0.24 11.0 3.3 1.6 8.4 0.1 2.4 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) GRIM-19 PF06212.10 T170993_3 - 1.7e-48 163.8 0.0 2.6e-48 163.2 0.0 1.3 1 0 0 1 1 1 1 GRIM-19 protein YjeF_N PF03853.13 T170993_3 - 7.3e-25 87.7 0.0 1.3e-24 86.9 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus Mucin2_WxxW PF13330.4 T170993_3 - 1.1e-18 67.7 0.0 2.1e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 Mucin-2 protein WxxW repeating region Ig_3 PF13927.4 T170993_3 - 2.8e-12 46.9 0.0 6.3e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain CarboxypepD_reg PF13620.4 T170993_3 - 5.3e-11 42.5 0.4 3.7e-07 30.2 0.1 2.9 2 0 0 2 2 2 2 Carboxypeptidase regulatory-like domain TSP_1 PF00090.17 T170993_3 - 5.1e-09 36.1 8.5 5.1e-09 36.1 8.5 2.5 2 0 0 2 2 2 1 Thrombospondin type 1 domain CarbopepD_reg_2 PF13715.4 T170993_3 - 4.4e-08 32.9 0.0 0.0038 17.1 0.0 2.4 2 0 0 2 2 2 2 CarboxypepD_reg-like domain I-set PF07679.14 T170993_3 - 1.9e-07 30.9 0.0 4.7e-07 29.6 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.4 T170993_3 - 2.7e-07 30.7 0.0 5.3e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T170993_3 - 0.00076 19.5 0.0 0.0018 18.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 T170993_3 - 0.13 12.3 0.0 1 9.4 0.0 2.2 1 1 1 2 2 2 0 Immunoglobulin V-set domain zf-H2C2_2 PF13465.4 T354437_2 - 9.1e-91 294.4 95.3 2.9e-08 33.7 0.6 16.8 16 1 0 16 16 16 13 Zinc-finger double domain zf-C2H2 PF00096.24 T354437_2 - 2.1e-64 210.4 107.3 1e-05 25.5 0.3 17.3 17 0 0 17 17 17 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T354437_2 - 2.3e-24 83.8 113.2 0.033 14.9 0.6 17.0 17 0 0 17 17 17 13 C2H2-type zinc finger KRAB PF01352.25 T354437_2 - 3.9e-20 71.1 0.0 7.5e-20 70.2 0.0 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 T354437_2 - 2.8e-08 33.6 67.4 0.34 10.9 2.1 10.7 4 2 8 13 13 13 10 Zinc ribbon domain zf-C2H2_6 PF13912.4 T354437_2 - 0.0021 17.8 84.0 0.55 10.1 0.4 14.2 14 0 0 14 14 14 8 C2H2-type zinc finger XPA_N PF01286.16 T354437_2 - 1.1 9.3 76.5 3.7 7.5 0.2 16.0 16 0 0 16 16 16 0 XPA protein N-terminal Voldacs PF03517.11 T064510_1 - 5.3e-31 107.5 0.8 5.3e-31 107.5 0.8 1.6 2 0 0 2 2 2 1 Regulator of volume decrease after cellular swelling S_100 PF01023.17 T021333_1 - 1.2e-16 60.0 0.3 2e-16 59.3 0.3 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 T021333_1 - 0.0059 16.9 0.3 0.0093 16.3 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair S_100 PF01023.17 T021333_2 - 2.6e-15 55.7 0.0 4.4e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain S_100 PF01023.17 T021333_3 - 8e-49 163.0 13.4 1.2e-17 63.2 0.5 3.3 3 0 0 3 3 3 3 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 T021333_3 - 5.8e-14 52.2 11.5 4.2e-05 23.8 0.4 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 T021333_3 - 2.4e-08 32.8 6.9 0.12 11.8 0.1 4.0 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.5 T021333_3 - 0.00087 19.1 1.1 0.33 10.8 0.0 3.1 3 0 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.4 T021333_3 - 0.0094 15.6 7.6 1 9.1 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.7 T021333_3 - 0.054 13.7 2.6 10 6.4 0.1 3.1 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Malic_M PF03949.13 T162247_3 - 2.7e-97 324.9 0.1 3.5e-97 324.6 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.17 T162247_3 - 1e-77 259.9 0.0 1.5e-77 259.4 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Lipocalin PF00061.21 T368806_3 - 3.9e-25 88.6 0.0 5.9e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family 7tm_2 PF00002.22 T337364_1 - 4.8e-21 75.1 0.1 6.7e-21 74.6 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) 7tm_2 PF00002.22 T337364_2 - 4.9e-57 192.9 12.0 6.9e-57 192.4 12.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 T337364_2 - 5e-22 77.8 4.8 5e-22 77.8 4.8 3.0 2 0 0 2 2 2 1 Hormone receptor domain Sec6 PF06046.11 T276943_2 - 5.6e-162 539.9 7.0 5.6e-162 539.9 7.0 1.4 2 0 0 2 2 2 1 Exocyst complex component Sec6 Baculo_PEP_C PF04513.10 T276943_2 - 0.31 10.9 6.0 0.15 12.0 2.7 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus EHN PF06441.10 T031722_1 - 4.8e-34 116.7 0.4 7.9e-34 116.0 0.4 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.18 T031722_1 - 3.4e-33 115.2 0.0 4.5e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold RhoGAP PF00620.25 T171063_1 - 7.3e-49 165.3 0.0 1.4e-48 164.4 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 T171063_1 - 8.7e-05 22.2 7.2 8.7e-05 22.2 7.2 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) 7tm_1 PF00001.19 T171063_3 - 1.5e-30 106.2 9.2 2e-30 105.8 9.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T171063_3 - 1.2e-07 31.3 3.7 1.6e-07 30.9 3.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 T171063_3 - 6.7e-05 22.6 2.3 0.0002 21.0 2.3 1.7 1 1 0 1 1 1 1 Olfactory receptor PRA1 PF03208.17 T171063_3 - 9.6 5.7 9.1 1.6 8.2 3.4 2.2 2 0 0 2 2 2 0 PRA1 family protein MAJIN PF15077.4 T060950_3 - 1.5e-71 241.0 2.4 3.9e-38 131.6 0.2 2.1 1 1 1 2 2 2 2 Membrane-anchored junction protein Hormone_6 PF00236.16 T060950_3 - 0.0022 17.8 5.6 0.0047 16.7 5.6 1.5 1 0 0 1 1 1 1 Glycoprotein hormone Cys_knot PF00007.20 T060950_3 - 0.028 14.6 8.7 0.051 13.7 8.7 1.4 1 0 0 1 1 1 0 Cystine-knot domain C1q PF00386.19 T007994_2 - 3e-37 127.5 0.1 4.2e-37 127.0 0.1 1.2 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 T007994_2 - 2.9e-34 116.5 185.4 4.6e-07 29.4 26.3 7.0 2 1 5 7 7 7 6 Collagen triple helix repeat (20 copies) UAA PF08449.9 T150147_1 - 2.8e-48 164.5 10.3 4e-48 164.0 10.3 1.1 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.14 T150147_1 - 3.2e-13 49.5 3.7 7e-08 32.0 0.6 2.0 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.18 T150147_1 - 2.4e-12 47.1 20.0 7.8e-08 32.4 12.1 2.3 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.8 T150147_1 - 0.014 14.3 0.2 0.014 14.3 0.2 2.1 1 1 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like zf-H2C2_2 PF13465.4 T380522_2 - 1.1e-36 123.5 76.1 6.3e-08 32.6 1.7 8.6 9 0 0 9 9 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 T380522_2 - 3.6e-32 108.9 71.4 1.9e-05 24.7 0.9 8.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T380522_2 - 1.6e-18 65.6 65.5 0.0093 16.6 2.3 8.7 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T380522_2 - 4e-14 52.0 54.7 0.00042 20.1 2.4 7.8 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T380522_2 - 0.0042 16.7 1.4 0.0042 16.7 1.4 8.4 9 0 0 9 9 9 2 zinc-finger C2H2-type zf-met PF12874.5 T380522_2 - 0.005 17.1 1.1 0.005 17.1 1.1 7.0 7 0 0 7 7 7 1 Zinc-finger of C2H2 type ROS_MUCR PF05443.9 T380522_2 - 0.17 11.8 0.8 0.39 10.7 0.8 1.5 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein zf-C2H2_jaz PF12171.6 T380522_2 - 1.6 9.0 35.5 1.6 9.0 0.2 7.9 7 1 1 8 8 8 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 T380522_2 - 4.9 7.4 15.1 0.28 11.4 0.2 3.5 2 1 3 5 5 5 0 zinc-finger-containing domain C1_4 PF07975.10 T380522_2 - 7.8 6.7 25.7 0.86 9.8 1.1 4.6 3 1 1 4 4 4 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.8 T380522_2 - 8.8 6.4 43.0 1.4 9.0 3.8 5.7 3 2 4 7 7 7 0 Zinc ribbon domain SCAN PF02023.15 T380522_3 - 1.2e-39 133.9 5.7 2.2e-39 133.1 5.7 1.4 1 0 0 1 1 1 1 SCAN domain Pkinase_Tyr PF07714.15 T287166_2 - 4.4e-99 330.8 0.6 9e-99 329.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.23 T287166_2 - 5.7e-48 163.4 0.0 1e-47 162.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 T287166_2 - 6.7e-21 74.0 0.0 1.4e-20 73.0 0.0 1.6 1 0 0 1 1 1 1 SH2 domain FCH PF00611.21 T287166_2 - 9e-11 41.8 2.6 2.3e-10 40.5 2.6 1.7 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain CG-1 PF03859.14 T140134_3 - 1.8e-38 130.8 1.7 4.1e-38 129.6 1.7 1.6 1 0 0 1 1 1 1 CG-1 domain R3H PF01424.20 T140134_3 - 1.7e-13 50.2 0.1 4.5e-13 48.9 0.1 1.8 1 0 0 1 1 1 1 R3H domain TIG PF01833.22 T140134_3 - 2.1e-10 40.4 0.0 4.2e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 IPT/TIG domain Ank_2 PF12796.5 T140134_3 - 1.9e-05 25.0 0.0 7.8e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T140134_3 - 2.1e-05 24.6 0.3 0.0049 17.1 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) IQ PF00612.25 T140134_3 - 0.00039 19.8 21.5 1 9.2 0.6 4.8 4 0 0 4 4 4 4 IQ calmodulin-binding motif Ank_3 PF13606.4 T140134_3 - 0.008 16.5 0.2 1.8 9.2 0.1 3.1 2 0 0 2 2 2 1 Ankyrin repeat RhoGEF67_u2 PF16614.3 T140134_3 - 0.023 14.7 0.3 0.16 11.9 0.3 2.5 1 0 0 1 1 1 0 Unstructured region two on RhoGEF 6 and 7 Ank_4 PF13637.4 T140134_3 - 0.051 14.1 0.7 0.52 10.8 0.2 2.4 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.28 T140134_3 - 0.069 13.5 0.0 27 5.3 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat Filament PF00038.19 T079016_1 - 6.8e-115 383.8 25.9 8e-115 383.6 25.9 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 T079016_1 - 1.3e-38 132.6 59.4 1.3e-38 132.6 59.4 3.4 2 1 1 3 3 1 1 Keratin type II head CENP-F_leu_zip PF10473.7 T079016_1 - 3.1e-05 23.9 24.9 0.00013 21.9 9.5 3.4 2 1 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.10 T079016_1 - 0.0002 21.3 27.5 0.0041 17.1 0.2 3.6 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 T079016_1 - 0.00023 20.0 26.6 0.0056 15.5 12.8 3.0 1 1 2 3 3 3 2 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 T079016_1 - 0.0037 17.4 25.7 0.013 15.6 2.6 3.4 2 1 0 3 3 3 2 JNK_SAPK-associated protein-1 TSNAXIP1_N PF15739.3 T079016_1 - 0.0059 16.8 1.5 0.0059 16.8 1.5 3.5 3 1 1 4 4 4 1 Translin-associated factor X-interacting N-terminus Alanine_zipper PF11839.6 T079016_1 - 0.0072 16.4 5.3 0.0072 16.4 5.3 1.9 2 0 0 2 2 1 1 Alanine-zipper, major outer membrane lipoprotein ATG16 PF08614.9 T079016_1 - 0.0095 16.0 23.6 0.17 11.9 0.9 3.1 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) DUF1192 PF06698.9 T079016_1 - 0.029 14.3 1.3 0.81 9.7 1.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Rootletin PF15035.4 T079016_1 - 0.067 13.1 18.8 0.011 15.7 3.6 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF4407 PF14362.4 T079016_1 - 0.12 11.6 17.4 66 2.6 17.4 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ADIP PF11559.6 T079016_1 - 0.2 11.6 25.8 0.015 15.3 10.3 3.4 2 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.7 T079016_1 - 0.22 10.5 15.1 0.064 12.2 10.5 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 She9_MDM33 PF05546.9 T079016_1 - 0.39 10.4 5.7 7.1 6.2 0.0 2.4 2 0 0 2 2 2 0 She9 / Mdm33 family AAA_13 PF13166.4 T079016_1 - 0.41 9.1 13.7 0.28 9.7 11.9 1.6 1 1 0 1 1 1 0 AAA domain ZapB PF06005.10 T079016_1 - 0.54 10.6 22.6 0.7 10.2 7.7 3.7 3 2 0 3 3 3 0 Cell division protein ZapB MCC-bdg_PDZ PF10506.7 T079016_1 - 0.64 9.9 10.4 0.14 12.1 5.8 2.2 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome TRAF_BIRC3_bd PF16673.3 T079016_1 - 0.91 9.2 4.2 10 5.8 1.0 3.0 3 0 0 3 3 2 0 TNF receptor-associated factor BIRC3 binding domain DUF948 PF06103.9 T079016_1 - 1.3 9.2 7.4 0.47 10.6 2.6 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TSC22 PF01166.16 T079016_1 - 1.5 9.0 11.9 5.6 7.2 0.5 3.9 3 1 0 3 3 3 0 TSC-22/dip/bun family T2SSM PF04612.10 T079016_1 - 1.6 8.6 6.6 1.6 8.7 3.2 2.3 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Golgin_A5 PF09787.7 T079016_1 - 1.8 7.8 21.5 5.1 6.3 11.0 2.5 1 1 1 2 2 2 0 Golgin subfamily A member 5 RPW8 PF05659.9 T079016_1 - 2.2 7.9 8.1 11 5.5 0.7 3.0 2 2 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 IncA PF04156.12 T079016_1 - 3.1 7.4 30.9 0.22 11.1 11.8 3.3 1 1 1 2 2 2 0 IncA protein Cnn_1N PF07989.9 T079016_1 - 3.5 7.7 14.7 4.7 7.3 7.3 3.6 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 FUSC PF04632.10 T079016_1 - 4 5.8 4.8 6.7 5.0 4.8 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family JIP_LZII PF16471.3 T079016_1 - 4.7 7.3 21.2 9.1 6.4 0.9 5.4 5 1 0 5 5 5 0 JNK-interacting protein leucine zipper II Lebercilin PF15619.4 T079016_1 - 5 6.6 28.0 0.55 9.7 13.4 3.2 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DASH_Duo1 PF08651.8 T079016_1 - 5.5 6.7 8.4 10 5.8 2.1 3.3 3 0 0 3 3 3 0 DASH complex subunit Duo1 KxDL PF10241.7 T079016_1 - 7.1 6.8 11.8 8.4 6.6 0.3 3.4 1 1 2 3 3 3 0 Uncharacterized conserved protein CHDCT2 PF08074.9 T079016_1 - 8.1 6.5 11.6 1 9.3 0.4 2.6 2 1 0 2 2 2 0 CHDCT2 (NUC038) domain DUF342 PF03961.11 T079016_1 - 9 4.6 16.1 9 4.6 9.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DUF883 PF05957.11 T079016_1 - 9.1 6.8 15.1 2.7 8.5 6.0 3.6 1 1 3 4 4 3 0 Bacterial protein of unknown function (DUF883) Ribosomal_S18 PF01084.18 T300494_1 - 7e-14 51.6 0.1 1.3e-13 50.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 DUF2358 PF10184.7 T300494_2 - 1.8e-32 111.8 1.2 2.5e-32 111.4 1.2 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) Acetyltransf_16 PF05301.9 T300494_3 - 7.8e-76 253.5 0.0 1e-75 253.1 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.5 T300494_3 - 0.018 15.3 0.0 0.036 14.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 T300494_3 - 0.043 13.9 0.0 0.075 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family UCH PF00443.27 T064602_2 - 2e-39 135.5 0.0 2.6e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 T064602_2 - 2e-22 80.1 0.0 1.8e-14 54.0 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase VIR_N PF15912.3 T064602_2 - 4.4 6.8 10.5 8.8 5.8 10.5 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal DUF4746 PF15928.3 T064602_2 - 8 5.7 16.4 12 5.0 16.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) GCV_T PF01571.19 T242536_1 - 4.4e-82 275.2 0.0 6.8e-82 274.6 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.9 T242536_1 - 1.1e-21 76.8 0.0 1.9e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain C2-set_2 PF08205.10 T301577_1 - 0.0015 18.4 0.0 0.0029 17.5 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 T301577_2 - 3.2e-10 40.0 0.0 5e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T301577_2 - 5.7e-06 26.7 0.0 1.1e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T301577_2 - 0.0016 18.4 0.0 0.0047 16.8 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 T301577_2 - 0.0095 16.0 0.0 0.028 14.4 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain tRNA-synt_1c PF00749.19 T146569_1 - 0.57 8.9 4.1 0.86 8.3 4.1 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain CWC25 PF12542.6 T146569_2 - 2.2e-19 70.0 0.0 2.2e-19 70.0 0.0 2.3 2 0 0 2 2 2 1 Pre-mRNA splicing factor Cir_N PF10197.7 T146569_2 - 1.6e-14 53.6 13.3 1.6e-14 53.6 13.3 3.1 3 0 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR PIP5K PF01504.16 T146569_3 - 1.2e-75 254.1 0.1 1.8e-75 253.6 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase zf-HC5HC2H_2 PF13832.4 T237614_2 - 1e-36 125.3 7.4 1e-36 125.3 7.4 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.7 T237614_2 - 4.8e-35 121.1 9.6 4.8e-35 121.1 9.6 2.1 2 0 0 2 2 2 1 Enhancer of polycomb-like OGG_N PF07934.10 T237614_2 - 3.9e-33 114.0 0.1 3.9e-33 114.0 0.1 1.8 2 0 0 2 2 2 1 8-oxoguanine DNA glycosylase, N-terminal domain zf-HC5HC2H PF13771.4 T237614_2 - 1.5e-25 89.1 6.1 1.5e-25 89.1 6.1 3.5 4 0 0 4 4 4 1 PHD-like zinc-binding domain Bromodomain PF00439.23 T237614_2 - 4.4e-22 77.8 0.6 8e-22 77.0 0.6 1.4 1 0 0 1 1 1 1 Bromodomain HhH-GPD PF00730.23 T237614_2 - 7.8e-19 68.0 0.0 1.8e-18 66.8 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein PWWP PF00855.15 T237614_2 - 2.9e-14 53.2 0.0 8.7e-14 51.6 0.0 1.9 1 0 0 1 1 1 1 PWWP domain PHD_2 PF13831.4 T237614_2 - 4.1e-14 51.7 3.3 4.1e-14 51.7 3.3 2.8 2 0 0 2 2 2 1 PHD-finger PHD PF00628.27 T237614_2 - 2.1e-07 30.6 27.0 1.6e-06 27.8 12.6 3.1 2 0 0 2 2 2 2 PHD-finger PGA2 PF07543.10 T237614_2 - 6.9 6.5 6.9 4.1 7.3 1.0 2.6 2 0 0 2 2 2 0 Protein trafficking PGA2 PX PF00787.22 T117992_2 - 0.0016 18.2 0.1 0.0029 17.5 0.1 1.3 1 0 0 1 1 1 1 PX domain Nefa_Nip30_N PF10187.7 T133124_3 - 5.6e-31 106.9 20.9 9.5e-31 106.1 20.9 1.4 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 IRS PF02174.15 T163677_1 - 5e-30 103.2 0.0 9.8e-30 102.3 0.0 1.5 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.27 T163677_1 - 3e-05 24.3 0.8 5.7e-05 23.4 0.8 1.5 1 0 0 1 1 1 1 PH domain CLZ PF16526.3 T194964_2 - 3.6e-29 100.8 6.7 6.3e-29 100.0 6.7 1.4 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ion_trans PF00520.29 T194964_2 - 6.8e-25 87.6 8.7 6.8e-25 87.6 8.7 2.3 2 0 0 2 2 2 1 Ion transport protein cNMP_binding PF00027.27 T194964_2 - 1.7e-16 59.9 0.0 2.7e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Laminin_G_2 PF02210.22 T189306_1 - 1.7e-154 506.8 7.6 2e-27 96.2 0.2 6.3 6 0 0 6 6 6 6 Laminin G domain Laminin_G_1 PF00054.21 T189306_1 - 2.8e-103 341.2 1.3 3e-23 82.3 0.0 6.4 6 0 0 6 6 6 6 Laminin G domain Laminin_G_3 PF13385.4 T189306_1 - 2.1e-21 76.5 3.4 0.0012 18.9 0.1 6.4 6 0 0 6 6 6 5 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 T189306_1 - 7.2e-11 42.0 27.2 2.8e-05 24.2 6.8 3.7 3 0 0 3 3 3 3 EGF-like domain Syndecan PF01034.18 T189306_1 - 4.9e-07 29.4 0.0 1.2e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Syndecan domain hEGF PF12661.5 T189306_1 - 0.0064 17.0 26.6 0.23 12.1 4.8 4.0 3 0 0 3 3 3 2 Human growth factor-like EGF DUF1080 PF06439.9 T189306_1 - 0.075 13.0 0.1 22 5.0 0.0 3.5 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1080) DUF202 PF02656.13 T189306_1 - 0.13 12.5 0.0 0.32 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Pkinase_Tyr PF07714.15 T300676_2 - 9.2e-84 280.6 0.0 1.2e-83 280.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T300676_2 - 2.1e-37 128.8 0.0 1.9e-36 125.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 T300676_2 - 7e-20 71.3 0.0 1.1e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Lamprin PF06403.9 T300676_2 - 0.056 13.3 0.5 0.12 12.2 0.5 1.5 1 0 0 1 1 1 0 Lamprin HECT PF00632.23 T152408_1 - 3e-100 335.5 0.0 3.9e-100 335.2 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 T152408_1 - 4.8e-29 99.9 10.0 5.9e-11 42.0 0.2 3.7 3 0 0 3 3 3 3 WW domain C2 PF00168.28 T152408_1 - 5.3e-12 45.8 0.1 2.7e-10 40.3 0.1 2.4 2 0 0 2 2 2 1 C2 domain Dynein_heavy PF03028.13 T319724_1 - 4.1e-234 778.8 0.0 4.1e-234 778.8 0.0 2.4 3 0 0 3 3 3 1 Dynein heavy chain and region D6 of dynein motor MT PF12777.5 T319724_1 - 2.2e-158 526.6 10.4 4.6e-158 525.6 10.4 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor DHC_N1 PF08385.10 T319724_1 - 7.2e-158 526.6 11.7 7.2e-158 526.6 11.7 2.2 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.5 T319724_1 - 3.7e-145 481.6 0.0 7.5e-145 480.5 0.0 1.5 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.5 T319724_1 - 4.1e-142 472.2 1.3 2.7e-140 466.2 0.5 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_8 PF12780.5 T319724_1 - 1e-138 460.8 0.0 2.2e-138 459.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 DHC_N2 PF08393.11 T319724_1 - 7.3e-119 397.3 16.7 7.3e-119 397.3 16.7 3.4 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.5 T319724_1 - 1.8e-83 278.9 1.0 1.8e-83 278.9 1.0 3.0 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_5 PF07728.12 T319724_1 - 1e-25 90.2 0.0 2.8e-11 43.4 0.0 5.4 5 0 0 5 5 4 4 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 T319724_1 - 1.4e-08 35.1 4.3 0.099 12.9 0.0 6.4 5 1 1 6 6 6 2 AAA ATPase domain AAA_22 PF13401.4 T319724_1 - 3.1e-07 30.6 0.0 0.84 9.8 0.0 5.3 4 0 0 4 4 4 1 AAA domain AAA PF00004.27 T319724_1 - 0.00041 20.7 0.5 0.96 9.7 0.0 4.9 6 0 0 6 6 4 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.20 T319724_1 - 0.00064 19.9 0.7 28 5.0 0.0 5.4 5 0 0 5 5 5 0 RNA helicase AAA_30 PF13604.4 T319724_1 - 0.0007 19.2 1.8 0.51 9.9 0.0 3.9 4 0 0 4 4 4 1 AAA domain Laminin_II PF06009.10 T319724_1 - 0.0011 18.9 3.3 0.0011 18.9 3.3 4.2 4 0 0 4 4 3 1 Laminin Domain II AAA_19 PF13245.4 T319724_1 - 0.0021 18.2 1.0 1.9 8.7 0.0 3.8 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.4 T319724_1 - 0.012 16.0 3.9 1.9 8.9 0.0 4.2 4 0 0 4 4 3 0 AAA domain NACHT PF05729.10 T319724_1 - 0.02 14.7 3.8 8.4 6.2 0.0 5.2 5 0 0 5 5 4 0 NACHT domain Sigma54_activat PF00158.24 T319724_1 - 0.023 14.3 0.0 1.6 8.3 0.0 3.2 4 0 0 4 4 3 0 Sigma-54 interaction domain TsaE PF02367.15 T319724_1 - 0.024 14.5 1.8 6.8 6.6 0.0 4.2 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.25 T319724_1 - 0.066 13.6 0.5 10 6.5 0.0 3.5 3 0 0 3 3 2 0 ABC transporter Roc PF08477.11 T319724_1 - 0.074 13.2 0.0 26 4.9 0.0 3.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.4 T319724_1 - 0.083 12.3 0.3 0.58 9.6 0.0 2.5 3 0 0 3 3 3 0 AAA domain FAM177 PF14774.4 T319724_1 - 0.097 12.9 0.0 0.47 10.7 0.0 2.3 1 0 0 1 1 1 0 FAM177 family Vir_act_alpha_C PF10400.7 T319724_1 - 0.17 12.5 1.4 15 6.2 0.0 4.4 4 0 0 4 4 3 0 Virulence activator alpha C-term PRANC PF09372.8 T319724_1 - 0.23 11.7 4.9 8 6.7 0.3 3.3 2 0 0 2 2 2 0 PRANC domain Fez1 PF06818.13 T319724_1 - 1.6 9.0 28.6 1.2 9.4 10.4 4.3 3 0 0 3 3 3 0 Fez1 PNISR PF15996.3 T308556_3 - 6.9e-48 163.4 20.4 2.2e-47 161.8 20.4 1.8 1 1 0 1 1 1 1 Arginine/serine-rich protein PNISR DUF4229 PF14012.4 T308556_3 - 0.88 9.6 6.7 1.9 8.5 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) LIM PF00412.20 T025959_2 - 7.4e-14 51.6 8.8 7.4e-14 51.6 8.8 1.9 2 0 0 2 2 2 1 LIM domain DUF4587 PF15248.4 T228353_1 - 4.9e-17 62.4 10.5 2.3e-16 60.2 10.5 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4587) cwf18 PF08315.10 T241882_1 - 6e-37 127.2 22.0 7.7e-37 126.8 22.0 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor Arg_tRNA_synt_N PF03485.14 T241882_1 - 0.14 12.6 1.4 0.24 11.9 1.4 1.3 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain Myosin_head PF00063.19 T144815_3 - 6.9e-114 381.4 0.0 1.3e-101 340.8 0.0 2.9 3 0 0 3 3 2 2 Myosin head (motor domain) Myosin_tail_1 PF01576.17 T144815_3 - 3.9e-19 67.9 182.9 3.2e-18 64.9 105.6 3.0 1 1 1 2 2 2 2 Myosin tail PDZ PF00595.22 T144815_3 - 2.8e-07 30.7 0.0 6.1e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) ATG16 PF08614.9 T144815_3 - 0.00061 19.9 16.4 0.00061 19.9 16.4 7.3 2 1 5 7 7 5 2 Autophagy protein 16 (ATG16) IQ PF00612.25 T144815_3 - 0.0012 18.3 0.3 0.0012 18.3 0.3 2.1 2 0 0 2 2 1 1 IQ calmodulin-binding motif PKcGMP_CC PF16808.3 T144815_3 - 0.0013 18.4 2.7 0.0013 18.4 2.7 8.1 8 0 0 8 8 7 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Reo_sigmaC PF04582.10 T144815_3 - 0.028 13.7 40.9 0.035 13.4 4.4 6.1 3 1 2 6 6 6 0 Reovirus sigma C capsid protein AAA_16 PF13191.4 T144815_3 - 0.052 13.8 0.0 0.052 13.8 0.0 5.8 4 2 1 5 5 3 0 AAA ATPase domain ATP_bind_1 PF03029.15 T144815_3 - 0.061 12.9 0.2 3.2 7.3 0.2 3.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.4 T144815_3 - 0.074 13.2 0.0 0.074 13.2 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_19 PF13245.4 T144815_3 - 0.12 12.6 2.1 0.25 11.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain DUF258 PF03193.14 T144815_3 - 0.17 11.7 1.0 3.5 7.4 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function, DUF258 AAA_18 PF13238.4 T144815_3 - 0.29 11.5 4.8 0.32 11.4 0.0 3.1 2 1 0 2 2 2 0 AAA domain PAD_M PF08527.8 T004480_2 - 5.3e-13 48.8 0.3 3.8e-09 36.3 0.1 2.2 2 0 0 2 2 2 2 Protein-arginine deiminase (PAD) middle domain PAD_M PF08527.8 T004480_3 - 4.5e-11 42.5 0.0 7.1e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) middle domain SET PF00856.26 T037568_3 - 1.2e-14 55.0 0.2 2e-14 54.2 0.2 1.4 1 0 0 1 1 1 1 SET domain Chromo PF00385.22 T037568_3 - 3e-12 46.1 1.0 5.2e-12 45.3 1.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CRAL_TRIO PF00650.18 T344745_2 - 4.5e-33 114.1 0.0 7.3e-33 113.4 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.4 T344745_2 - 1.3e-06 28.4 0.0 2.4e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.13 T344745_2 - 1.9e-06 27.8 0.2 5.5e-06 26.3 0.0 1.9 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Inhibitor_Mig-6 PF11555.6 T344745_3 - 0.061 13.3 1.6 0.18 11.8 0.5 2.3 2 0 0 2 2 2 0 EGFR receptor inhibitor Mig-6 DUF4551 PF15087.4 T127411_2 - 2.9 6.5 3.2 3.8 6.1 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Rrn6 PF10214.7 T127411_3 - 0.53 8.5 3.6 0.66 8.2 3.6 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Bradykinin PF06753.10 T061480_1 - 0.046 13.3 11.0 1.6 8.4 1.1 3.2 2 0 0 2 2 2 0 Bradykinin eIF-1a PF01176.17 T061480_3 - 4.1e-17 61.6 0.1 6.5e-17 61.0 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 SH2 PF00017.22 T366876_3 - 1.2e-14 54.0 0.2 2.2e-14 53.1 0.2 1.5 1 0 0 1 1 1 1 SH2 domain RasGEF PF00617.17 T366876_3 - 2.4e-11 44.0 0.0 4.1e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain LRR_6 PF13516.4 T052177_3 - 7.7e-30 100.3 26.5 0.00014 21.5 0.6 11.6 12 0 0 12 12 12 8 Leucine Rich repeat LRR_4 PF12799.5 T052177_3 - 2.4e-09 37.2 12.8 0.2 12.0 0.8 7.5 7 0 0 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T052177_3 - 0.0041 16.7 9.1 6.8 6.4 0.2 6.0 6 0 0 6 6 6 2 Leucine rich repeat Brix PF04427.16 T199166_1 - 8.1e-28 97.7 0.0 1.1e-27 97.2 0.0 1.2 1 0 0 1 1 1 1 Brix domain Y_phosphatase PF00102.25 T199166_1 - 2.9e-25 89.1 0.0 4e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase PF00102.25 T199166_2 - 9e-39 133.3 0.0 1.4e-38 132.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 T199166_2 - 0.029 14.2 0.0 0.045 13.6 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family GDP_Man_Dehyd PF16363.3 T097687_1 - 1.6e-67 228.1 0.1 2e-67 227.8 0.1 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.19 T097687_1 - 1.4e-52 178.5 0.1 1.8e-52 178.1 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.13 T097687_1 - 1.7e-21 76.5 0.0 4.4e-21 75.1 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.15 T097687_1 - 2.5e-21 75.9 0.0 3.3e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.17 T097687_1 - 6.6e-21 74.4 0.1 9.4e-21 73.9 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.10 T097687_1 - 4.6e-14 52.1 0.0 7.5e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.4 T097687_1 - 0.00076 19.3 0.0 0.0012 18.7 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Ank_2 PF12796.5 T290106_2 - 8.1e-149 484.5 36.5 5e-19 68.5 0.6 12.2 3 3 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T290106_2 - 2.2e-118 385.1 16.0 1.1e-09 38.4 0.1 15.8 8 3 7 16 16 16 16 Ankyrin repeats (many copies) Ank PF00023.28 T290106_2 - 6.9e-110 355.0 50.9 6.2e-08 32.6 0.0 24.5 24 0 0 24 24 24 21 Ankyrin repeat Ank_3 PF13606.4 T290106_2 - 4.8e-100 315.2 28.8 8e-05 22.6 0.0 25.5 25 0 0 25 25 25 21 Ankyrin repeat Ank_5 PF13857.4 T290106_2 - 4.4e-96 313.1 45.6 6.7e-08 32.6 0.0 20.6 6 4 15 21 21 21 20 Ankyrin repeats (many copies) KH_1 PF00013.27 T290106_2 - 1.6e-14 53.3 0.6 3.6e-14 52.2 0.6 1.7 1 0 0 1 1 1 1 KH domain DUF4746 PF15928.3 T290106_2 - 0.69 9.1 13.6 1.2 8.3 13.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1777 PF08648.10 T290106_2 - 0.76 9.9 13.3 2.4 8.3 13.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) NARP1 PF12569.6 T290106_2 - 2.9 6.5 18.2 4.5 5.9 18.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CobT PF06213.10 T290106_2 - 5.2 6.2 19.1 10 5.3 19.1 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT p450 PF00067.20 T080770_1 - 3.1e-91 306.3 0.0 4e-91 306.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_4 PF02390.15 T080770_2 - 4.6e-57 192.1 0.0 6.2e-57 191.7 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase MFS_1 PF07690.14 T298990_1 - 2e-07 30.1 2.3 6.3e-05 21.9 0.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF1725 PF08333.9 T011359_2 - 1.1e-08 34.3 0.4 1.8e-08 33.7 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Ldl_recept_a PF00057.16 T011359_3 - 1.7e-08 34.4 32.4 7.8e-05 22.7 4.0 4.0 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A I-set PF07679.14 T208173_1 - 2e-83 274.4 0.0 5.2e-21 74.4 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 T208173_1 - 3.5e-42 142.8 0.0 7e-09 36.1 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain NTP_transferase PF00483.21 T208173_1 - 1.9e-27 96.3 0.0 2.6e-27 95.9 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Ig_2 PF13895.4 T208173_1 - 4e-25 87.8 0.1 1.5e-05 25.1 0.0 6.4 6 0 0 6 6 6 5 Immunoglobulin domain ig PF00047.23 T208173_1 - 3.6e-23 81.4 0.0 0.00034 20.6 0.0 5.5 5 0 0 5 5 5 4 Immunoglobulin domain Pkinase PF00069.23 T208173_1 - 1.9e-09 37.1 0.0 2.7e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Hexapep PF00132.22 T208173_1 - 2.4e-05 23.8 2.6 5e-05 22.7 0.3 2.4 2 0 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) V-set PF07686.15 T208173_1 - 6.3e-05 23.0 0.8 0.089 12.8 0.0 4.5 4 1 0 4 4 4 1 Immunoglobulin V-set domain Pkinase_Tyr PF07714.15 T208173_1 - 0.0035 16.5 0.0 0.0054 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase fn3 PF00041.19 T208173_1 - 0.0071 16.5 0.1 0.013 15.7 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain C2-set_2 PF08205.10 T208173_1 - 0.011 15.7 0.0 7.7 6.5 0.0 3.6 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 T208173_1 - 0.029 14.3 0.4 2.5 8.1 0.1 3.0 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain DUF4954 PF16314.3 T208173_1 - 0.24 9.3 0.1 0.34 8.9 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) ASC PF00858.22 T208173_2 - 4.9e-92 308.9 0.0 6.6e-92 308.4 0.0 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Pkinase PF00069.23 T208173_2 - 1.4e-90 303.1 0.0 4.1e-55 186.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 T208173_2 - 1e-39 136.2 0.0 1.2e-26 93.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase I-set PF07679.14 T208173_2 - 1.6e-13 50.4 0.0 2.5e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T208173_2 - 8.4e-11 42.2 0.0 2.4e-10 40.8 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T208173_2 - 6e-05 23.2 0.1 0.00042 20.5 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 T208173_2 - 0.0054 16.7 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.19 T208173_2 - 0.01 16.0 0.0 0.028 14.6 0.0 1.8 1 0 0 1 1 1 0 Fibronectin type III domain Kinase-like PF14531.4 T208173_2 - 0.15 11.2 0.0 0.28 10.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.12 T208173_2 - 0.19 10.9 0.0 0.7 9.1 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family I-set PF07679.14 T208173_3 - 1.7e-81 268.3 0.0 1.4e-21 76.2 0.0 4.8 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.4 T208173_3 - 5e-48 161.5 0.0 1.5e-10 41.4 0.0 4.9 4 0 0 4 4 4 4 Immunoglobulin domain SPEG_u2 PF16650.3 T208173_3 - 5.6e-32 109.6 14.4 3.8e-31 106.9 14.4 2.7 1 0 0 1 1 1 1 Unstructured region on SPEG complex protein Ig_2 PF13895.4 T208173_3 - 3.9e-28 97.5 0.0 7.1e-07 29.3 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 T208173_3 - 4.9e-24 84.2 0.0 3e-06 27.2 0.0 5.4 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.15 T208173_3 - 1.2e-07 31.7 0.0 0.75 9.9 0.0 5.1 4 2 0 4 4 4 3 Immunoglobulin V-set domain Asp_Arg_Hydrox PF05118.13 T231332_3 - 1.4e-43 148.3 0.0 2.7e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase BTB PF00651.29 T173851_1 - 7.5e-08 32.5 0.0 2.9e-07 30.6 0.0 1.7 1 1 0 1 1 1 1 BTB/POZ domain FYRC PF05965.12 T173851_2 - 2.8e-22 78.5 0.0 7.3e-22 77.2 0.0 1.8 2 0 0 2 2 2 1 F/Y rich C-terminus SET PF00856.26 T173851_2 - 3.1e-22 79.6 1.1 5.4e-22 78.8 0.2 1.9 2 0 0 2 2 2 1 SET domain PHD PF00628.27 T173851_2 - 6.1e-15 54.7 46.7 2.3e-08 33.7 8.4 6.4 6 1 1 7 7 7 3 PHD-finger FYRN PF05964.12 T173851_2 - 1e-14 54.0 0.2 2e-14 53.1 0.2 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus zf-CXXC PF02008.18 T173851_2 - 8.5e-12 44.8 20.2 8.5e-12 44.8 20.2 5.2 4 0 0 4 4 2 1 CXXC zinc finger domain zf-HC5HC2H PF13771.4 T173851_2 - 1.4e-10 41.1 10.3 1.4e-10 41.1 10.3 5.5 4 1 1 5 5 3 1 PHD-like zinc-binding domain zf-H2C2_2 PF13465.4 T173851_2 - 0.00018 21.7 23.6 0.00028 21.0 0.8 6.0 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.24 T173851_2 - 0.00047 20.3 30.6 0.061 13.7 2.4 6.4 5 0 0 5 5 5 3 Zinc finger, C2H2 type Bromodomain PF00439.23 T173851_2 - 0.13 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Bromodomain zf-C2H2_jaz PF12171.6 T173851_2 - 0.44 10.8 4.8 12 6.3 0.0 3.3 3 0 0 3 3 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T173851_2 - 0.59 10.5 18.6 0.023 15.0 0.4 4.2 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Cohesin_load PF10345.7 T170910_1 - 3.4e-30 104.9 0.0 4.4e-30 104.5 0.0 1.0 1 0 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.4 T170910_1 - 0.0018 18.4 0.1 0.0092 16.1 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat Cohesin_load PF10345.7 T170910_2 - 1.3e-93 314.3 8.9 1.7e-93 313.9 8.9 1.1 1 0 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.4 T170910_2 - 0.00013 22.1 2.8 0.16 12.1 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 T170910_2 - 0.012 16.0 0.3 0.012 16.0 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 T170910_2 - 0.023 14.8 2.4 7.6 6.9 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Cmyb_C PF09316.8 T311855_2 - 6e-73 243.8 4.0 9.7e-73 243.1 4.0 1.3 1 0 0 1 1 1 1 C-myb, C-terminal Myb_DNA-binding PF00249.29 T311855_2 - 3.8e-54 180.5 18.2 1.5e-18 66.6 1.8 3.6 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T311855_2 - 2.9e-39 133.0 16.7 5.5e-17 61.6 2.0 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain LMSTEN PF07988.10 T311855_2 - 3.5e-26 90.2 0.5 7.2e-26 89.2 0.5 1.6 1 0 0 1 1 1 1 LMSTEN motif Myb_DNA-bind_7 PF15963.3 T311855_2 - 4.2e-09 36.0 9.8 0.00032 20.4 0.2 3.8 2 1 2 4 4 4 2 Myb DNA-binding like SLIDE PF09111.8 T311855_2 - 1.4e-05 25.0 0.5 2.4 8.1 0.0 3.4 1 1 2 3 3 3 3 SLIDE SANT_DAMP1_like PF16282.3 T311855_2 - 0.00095 19.2 3.7 0.7 10.0 0.0 3.3 1 1 2 3 3 3 1 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.6 T311855_2 - 0.48 10.4 7.8 5.3 7.1 0.5 3.4 1 1 2 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain T-box PF00907.20 T024674_3 - 1.7e-57 194.5 0.0 2.5e-57 193.9 0.0 1.2 1 0 0 1 1 1 1 T-box ig PF00047.23 T181004_1 - 5.5e-35 119.3 0.0 2.1e-13 50.1 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T181004_1 - 5e-16 58.7 0.0 1.3e-07 31.7 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 T181004_1 - 1.2e-14 54.5 0.0 0.00013 22.3 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T181004_1 - 6.8e-07 29.3 0.0 5 7.2 0.0 5.1 5 1 1 6 6 6 3 Immunoglobulin V-set domain MAP17 PF15807.3 T181004_1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 I-set PF07679.14 T043085_1 - 7.6e-105 343.1 0.0 2.9e-20 72.0 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 T043085_1 - 2.6e-74 245.7 0.1 5.2e-14 52.5 0.0 6.0 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 T043085_1 - 3.4e-48 161.6 0.2 2.6e-09 37.0 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 T043085_1 - 1.2e-47 160.0 0.6 7.3e-09 35.7 0.0 6.0 6 0 0 6 6 6 5 Immunoglobulin domain V-set PF07686.15 T043085_1 - 7.9e-17 61.3 1.5 0.035 14.1 0.0 7.5 5 3 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 T043085_1 - 7.7e-10 38.6 1.2 0.73 9.8 0.0 5.1 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 T043085_1 - 6.1e-08 32.9 0.5 0.2 12.0 0.0 5.0 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 T043085_1 - 0.0019 18.0 0.0 19 5.3 0.0 3.6 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 T043085_1 - 0.0026 17.8 0.0 1.7 8.7 0.0 3.9 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 BiPBP_C PF06832.10 T043085_1 - 0.098 12.6 0.0 5.8 6.9 0.0 3.1 4 0 0 4 4 4 0 Penicillin-Binding Protein C-terminus Family Glyco_transf_25 PF01755.15 T367140_2 - 1.1e-28 100.4 0.0 8.2e-28 97.5 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_tranf_2_4 PF13704.4 T367140_2 - 6.2e-08 32.9 0.1 1.3e-07 31.9 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Seipin PF06775.12 T060179_2 - 2.3e-57 194.1 0.9 3.8e-57 193.5 0.9 1.3 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) AAA_33 PF13671.4 T060179_2 - 5.1e-23 81.7 0.0 8.2e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain SPRY PF00622.26 T060179_2 - 6e-15 55.3 0.1 1.2e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 SPRY domain SAP PF02037.25 T060179_2 - 1.2e-07 31.2 3.0 2.5e-07 30.1 3.0 1.6 1 0 0 1 1 1 1 SAP domain Zeta_toxin PF06414.10 T060179_2 - 0.00067 18.9 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin fn3 PF00041.19 T060179_2 - 0.0044 17.2 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain AAA_18 PF13238.4 T060179_2 - 0.006 17.0 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 T060179_2 - 0.033 13.5 0.1 0.05 12.9 0.1 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_17 PF13207.4 T060179_2 - 0.15 12.3 0.4 0.29 11.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain LAT PF15234.4 T060179_3 - 9.8 5.7 7.1 21 4.7 7.1 1.5 1 0 0 1 1 1 0 Linker for activation of T-cells ADK PF00406.20 T007500_1 - 2e-59 199.9 0.0 2.7e-59 199.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.4 T007500_1 - 6.1e-22 78.4 0.0 9.2e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.12 T007500_1 - 9e-16 57.5 0.0 2.5e-15 56.1 0.0 1.9 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.4 T007500_1 - 0.00072 19.6 0.0 0.0015 18.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 T007500_1 - 0.13 12.6 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.16 T007500_1 - 0.18 11.4 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase PRY PF13765.4 T299247_3 - 4.5e-24 83.7 0.5 1.2e-23 82.3 0.5 1.8 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 T299247_3 - 3.4e-13 49.6 0.0 8.1e-13 48.4 0.0 1.6 2 0 0 2 2 2 1 SPRY domain SIT PF15330.4 T299247_3 - 6 7.2 5.5 4.7 7.5 0.5 2.3 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT RNase_P_p30 PF01876.14 T046062_3 - 4.4e-52 176.6 0.0 8.2e-52 175.7 0.0 1.4 1 1 0 1 1 1 1 RNase P subunit p30 TERB2 PF15101.4 T115831_2 - 2.4e-20 73.4 0.4 3.1e-20 73.0 0.4 1.1 1 0 0 1 1 1 1 Telomere-associated protein TERB2 SSF PF00474.15 T129093_2 - 2.2e-85 286.9 23.4 7.3e-56 189.6 18.6 2.3 2 0 0 2 2 2 2 Sodium:solute symporter family SSF PF00474.15 T129093_3 - 5.4e-16 58.3 0.1 7.9e-16 57.8 0.1 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family FSA_C PF10479.7 T270701_1 - 4.1e-91 306.0 2.5 4.1e-91 306.0 2.5 1.9 2 1 0 2 2 2 1 Fragile site-associated protein C-terminus FSA_C PF10479.7 T270701_3 - 1.3e-64 218.4 4.2 8.9e-34 116.5 0.5 2.0 1 1 1 2 2 2 2 Fragile site-associated protein C-terminus MFS_1 PF07690.14 T042521_1 - 1.1e-32 113.3 14.7 1.1e-32 113.3 14.7 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Clusterin PF01093.15 T042521_3 - 0.081 11.8 3.6 0.11 11.4 3.6 1.1 1 0 0 1 1 1 0 Clusterin UIM PF02809.18 T294181_3 - 0.0012 18.5 9.5 0.027 14.2 2.3 2.6 2 0 0 2 2 2 2 Ubiquitin interaction motif Rad50_zn_hook PF04423.12 T294181_3 - 0.25 11.1 9.3 0.53 10.0 0.3 3.6 3 0 0 3 3 3 0 Rad50 zinc hook motif C1-set PF07654.13 T230375_2 - 8.2e-29 99.8 1.6 2.2e-28 98.4 0.6 2.1 2 0 0 2 2 2 1 Immunoglobulin C1-set domain V-set PF07686.15 T230375_2 - 2.2e-20 72.7 2.6 5.7e-20 71.4 0.2 2.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T230375_2 - 2.9e-11 43.7 5.4 2.2e-05 24.8 0.3 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 T230375_2 - 9.8e-09 35.0 0.4 6.2e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 T230375_2 - 4.2e-08 33.1 4.0 0.0024 17.9 0.4 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 T230375_2 - 3e-05 24.1 6.8 0.013 15.7 0.5 2.5 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 T230375_2 - 0.00029 20.7 1.1 0.00055 19.8 0.6 1.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Marek_A PF02124.13 T230375_2 - 0.017 14.8 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A OATP PF03137.18 T075052_1 - 2.1e-39 135.1 9.7 2.9e-39 134.7 9.7 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.13 T075052_1 - 1.8e-09 37.5 1.9 4.6e-09 36.2 1.9 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 T075052_1 - 0.0029 17.5 4.9 0.0037 17.1 2.8 2.3 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain OATP PF03137.18 T075052_3 - 1.8e-122 409.3 14.3 2.6e-122 408.8 14.3 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 T075052_3 - 1.8e-24 86.2 8.5 5.8e-24 84.5 8.5 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily zf-C3Hc3H PF13891.4 T206235_2 - 2.4e-33 114.1 20.5 1.9e-16 60.1 6.1 2.8 2 0 0 2 2 2 2 Potential DNA-binding domain zf-primase PF09329.9 T206235_2 - 0.00042 19.9 2.5 0.12 12.0 0.2 2.7 2 0 0 2 2 2 2 Primase zinc finger Phospholip_A2_2 PF05826.10 T144672_2 - 0.00065 19.7 6.2 0.0013 18.8 6.2 1.4 1 0 0 1 1 1 1 Phospholipase A2 EGF_CA PF07645.13 T226816_1 - 4.3e-07 29.9 6.8 1.4e-06 28.2 6.8 2.0 1 0 0 1 1 1 1 Calcium-binding EGF domain EGF_3 PF12947.5 T226816_1 - 0.0091 16.0 4.7 0.0091 16.0 4.7 2.3 2 0 0 2 2 2 1 EGF domain Zona_pellucida PF00100.21 T226816_3 - 2.6e-38 132.1 3.4 3.5e-38 131.7 3.4 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain GLTP PF08718.9 T086207_1 - 1.1e-42 145.6 0.0 1.8e-42 145.0 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) ETRAMP PF09716.8 T086207_2 - 0.51 10.3 3.6 1.5 8.8 0.6 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) tRNA-synt_1d PF00750.17 T307732_1 - 4.2e-95 318.5 1.0 5.8e-95 318.0 1.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.13 T307732_1 - 1.3e-20 73.6 0.0 2.4e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 DALR anticodon binding domain Mnd1 PF03962.13 T305653_1 - 0.38 10.4 8.0 0.017 14.9 1.2 1.9 2 0 0 2 2 2 0 Mnd1 family SCAN PF02023.15 T181690_2 - 3.8e-11 42.5 0.1 5.4e-11 42.0 0.1 1.2 1 0 0 1 1 1 1 SCAN domain Lipocalin PF00061.21 T120298_2 - 3.3e-22 79.1 0.3 4.2e-22 78.8 0.3 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 T120298_2 - 1.8e-05 24.5 0.0 2.7e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family KRAB PF01352.25 T335558_2 - 3e-30 103.5 3.1 4.6e-21 74.1 0.3 2.5 2 0 0 2 2 2 2 KRAB box Dimer_Tnp_hAT PF05699.12 T335558_2 - 3.9e-07 29.6 0.2 8.1e-07 28.6 0.2 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4371 PF14291.4 T335558_2 - 0.031 13.8 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) DUF4584 PF15223.4 T038181_3 - 5.6e-171 569.4 8.7 5.6e-171 569.4 8.7 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4584) Ski_Sno PF02437.15 T038181_3 - 1.2e-13 50.6 0.0 2.3e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 SKI/SNO/DAC family SDA1 PF05285.10 T038181_3 - 0.19 11.0 11.1 0.4 10.0 11.1 1.4 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.10 T038181_3 - 0.92 7.5 11.4 1.4 6.9 11.4 1.1 1 0 0 1 1 1 0 Nop14-like family Macoilin PF09726.7 T038181_3 - 3.6 5.9 11.2 6.3 5.1 11.2 1.3 1 0 0 1 1 1 0 Transmembrane protein 7tm_2 PF00002.22 T007117_3 - 1.1e-62 211.4 12.9 1.6e-62 210.9 12.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.3 T007117_3 - 2.3e-36 125.1 0.0 3.3e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain TSP_1 PF00090.17 T007117_3 - 1.2e-26 92.5 51.2 1.1e-10 41.4 10.9 4.1 3 0 0 3 3 3 3 Thrombospondin type 1 domain GPS PF01825.19 T007117_3 - 2.1e-12 47.3 4.5 9.1e-12 45.3 4.5 2.3 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_1 PF00001.19 T007117_3 - 0.00093 18.4 0.0 0.0017 17.6 0.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MFS_1 PF07690.14 T299006_1 - 1.9e-05 23.7 1.2 3.3e-05 22.8 0.3 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Eapp_C PF10238.7 T299006_1 - 6.3 6.7 8.7 12 5.8 8.7 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein MFS_1 PF07690.14 T299006_2 - 6.8e-13 48.1 13.6 8.4e-10 38.0 1.1 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily Zwint PF15556.4 T042357_1 - 2.1e-99 332.0 27.2 9.1e-83 277.5 22.1 2.1 1 1 1 2 2 2 2 ZW10 interactor DUF2968 PF11180.6 T042357_1 - 5.5 6.5 16.7 8.6 5.9 16.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Mpv17_PMP22 PF04117.10 T186714_1 - 2.9e-21 75.3 0.3 6.3e-21 74.2 0.3 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family WD40 PF00400.30 T186714_1 - 3.1e-07 30.8 1.1 0.098 13.4 0.1 4.7 4 0 0 4 4 4 2 WD domain, G-beta repeat CRF PF00473.15 T186714_2 - 1.7e-16 59.9 0.5 3.8e-16 58.8 0.5 1.6 1 0 0 1 1 1 1 Corticotropin-releasing factor family Med9 PF07544.11 T143024_3 - 2.2e-21 75.6 2.8 3.2e-21 75.1 2.8 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.6 T143024_3 - 0.01 15.9 12.9 0.068 13.3 12.9 2.0 1 1 0 1 1 1 0 Subunit 21 of Mediator complex TBPIP PF07106.11 T143024_3 - 0.17 11.5 0.6 0.26 10.9 0.6 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DEC-1_N PF04625.11 T143024_3 - 0.32 9.8 6.0 0.46 9.3 6.0 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region zf-H2C2_2 PF13465.4 T354377_3 - 5.6e-150 481.6 198.0 1.1e-07 31.9 0.7 29.7 30 0 0 30 30 30 24 Zinc-finger double domain zf-C2H2 PF00096.24 T354377_3 - 8.6e-105 337.6 220.1 7.8e-06 25.9 1.3 26.6 27 0 0 27 27 27 24 Zinc finger, C2H2 type Ribosomal_L2_C PF03947.16 T354377_3 - 8.1e-47 158.4 3.1 1.6e-46 157.4 3.1 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain KRAB PF01352.25 T354377_3 - 2.5e-45 151.8 0.0 4.4e-22 77.4 0.0 2.4 2 0 0 2 2 2 2 KRAB box zf-C2H2_4 PF13894.4 T354377_3 - 2.3e-39 130.5 215.6 0.0023 18.5 1.8 27.2 26 0 0 26 26 26 23 C2H2-type zinc finger Ribosomal_L2 PF00181.21 T354377_3 - 1.8e-17 62.9 0.2 4.3e-17 61.7 0.2 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Zn-ribbon_8 PF09723.8 T354377_3 - 1.6e-09 37.6 121.3 0.012 15.6 1.0 15.2 12 2 4 17 17 17 12 Zinc ribbon domain zf-C2H2_6 PF13912.4 T354377_3 - 2.9e-09 36.5 168.4 0.021 14.6 0.9 24.2 26 0 0 26 26 26 14 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T354377_3 - 0.0036 17.9 93.3 1.5 9.5 3.2 12.9 4 2 11 15 15 15 8 zinc-ribbon family RHD_DNA_bind PF00554.20 T061343_2 - 1.3e-68 230.1 0.0 1.9e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 T061343_2 - 1.6e-36 124.3 0.0 3.4e-36 123.3 0.0 1.6 1 0 0 1 1 1 1 Rel homology dimerisation domain zf-H2C2_2 PF13465.4 T353360_3 - 5.1e-68 222.5 90.9 1.7e-08 34.4 0.1 12.9 12 0 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.24 T353360_3 - 2.6e-46 153.4 89.1 3.9e-06 26.9 0.3 11.8 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T353360_3 - 1.4e-20 72.1 86.2 0.024 15.3 1.5 12.0 11 0 0 11 11 11 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T353360_3 - 4.2e-07 29.8 46.3 0.035 14.1 0.6 7.1 4 1 3 7 7 7 7 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T353360_3 - 0.0093 16.6 32.1 0.78 10.4 1.1 5.8 2 2 4 6 6 6 2 zinc-ribbon family zf-C2H2_6 PF13912.4 T353360_3 - 8.1 6.4 61.9 1.2 9.0 1.9 10.6 11 0 0 11 11 11 0 C2H2-type zinc finger Pax2_C PF12403.6 T197107_1 - 3.2e-53 178.5 15.5 6.5e-53 177.5 15.5 1.5 1 0 0 1 1 1 1 Paired-box protein 2 C terminal PAX PF00292.16 T197107_2 - 3.7e-71 236.8 0.4 6.2e-71 236.1 0.4 1.4 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.4 T197107_2 - 0.00066 19.3 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain MHC_II_alpha PF00993.18 T301703_1 - 6.7e-20 70.4 0.1 4e-19 67.9 0.1 2.0 2 0 0 2 2 2 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 T301703_1 - 7.4e-06 25.1 0.2 1.3e-05 24.4 0.2 1.3 1 0 0 1 1 1 1 C1-set C-terminal domain SKG6 PF08693.8 T301703_1 - 0.038 13.3 3.4 0.078 12.3 3.4 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RFX_DNA_binding PF02257.13 T195439_1 - 1.8e-25 89.2 0.0 3.7e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain Ets PF00178.20 T302590_2 - 1.2e-25 89.7 0.8 2.2e-25 88.8 0.8 1.4 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 T302590_2 - 7.4e-23 80.2 0.0 1.8e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PNP_UDP_1 PF01048.18 T323656_1 - 0.044 12.9 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 Phosphorylase superfamily PNP_UDP_1 PF01048.18 T323656_2 - 6.4e-12 45.1 0.0 1.1e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily ENTH PF01417.18 T156356_1 - 1.8e-06 27.9 0.0 2.8e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 ENTH domain zf-H2C2_2 PF13465.4 T090515_1 - 1.8e-135 435.7 128.8 1.3e-09 37.9 0.4 22.1 21 0 0 21 21 21 18 Zinc-finger double domain zf-C2H2 PF00096.24 T090515_1 - 3.5e-95 307.4 151.8 2e-06 27.8 1.0 20.5 20 0 0 20 20 20 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T090515_1 - 6.1e-56 182.1 141.1 0.002 18.7 1.4 20.8 19 0 0 19 19 19 19 C2H2-type zinc finger KRAB PF01352.25 T090515_1 - 2.1e-22 78.4 0.4 5.1e-22 77.1 0.4 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T090515_1 - 1.2e-07 31.3 128.0 0.065 13.1 0.6 19.2 20 0 0 20 20 20 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T090515_1 - 1.1e-05 25.4 101.6 0.32 11.2 0.2 17.8 19 0 0 19 19 19 11 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T090515_1 - 2.6e-05 24.7 79.0 0.48 11.1 2.1 10.0 1 1 12 13 13 13 9 zinc-ribbon family Zn-ribbon_8 PF09723.8 T090515_1 - 0.49 10.4 100.0 0.51 10.4 4.9 11.8 1 1 14 17 17 17 0 Zinc ribbon domain RCC1 PF00415.16 T055633_2 - 6.5e-32 109.8 7.4 2e-10 41.0 0.2 3.4 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 T055633_2 - 3.2e-17 61.7 16.0 5.2e-09 35.5 0.6 4.5 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.16 T055633_3 - 2.3e-29 101.6 10.7 1.3e-08 35.2 2.0 5.0 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 T055633_3 - 9.2e-10 38.0 30.1 9.6e-08 31.5 0.9 5.8 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat SCP2 PF02036.15 T119342_1 - 1.5e-15 57.3 0.0 3.8e-15 56.1 0.0 1.7 2 0 0 2 2 2 1 SCP-2 sterol transfer family Band_7 PF01145.23 T119342_1 - 0.0016 18.4 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Arf PF00025.19 T027984_1 - 2.5e-44 150.7 0.1 3.6e-44 150.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 T027984_1 - 3.4e-16 59.1 0.0 4.5e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T027984_1 - 9.1e-15 54.8 0.0 1.3e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.10 T027984_1 - 1.5e-07 30.9 0.0 2e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 T027984_1 - 3e-06 26.7 0.0 4.3e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 T027984_1 - 0.0001 21.4 0.1 0.0036 16.4 0.0 2.1 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.21 T027984_1 - 0.00051 20.0 0.0 0.00087 19.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Y_phosphatase PF00102.25 T027984_3 - 1.8e-76 256.6 0.0 2.5e-76 256.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 T027984_3 - 0.0083 15.8 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 T027984_3 - 0.042 13.7 0.0 0.065 13.0 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family Fumble PF03630.12 T213042_1 - 2.6e-91 306.1 0.0 3.5e-91 305.7 0.0 1.1 1 0 0 1 1 1 1 Fumble Fumble PF03630.12 T213042_3 - 0.0009 18.4 0.0 0.0012 18.0 0.0 1.1 1 0 0 1 1 1 1 Fumble Cu_amine_oxid PF01179.18 T335839_1 - 1.1e-118 396.5 0.1 1.7e-118 396.0 0.1 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.14 T335839_1 - 4.7e-31 106.7 0.0 9.4e-31 105.8 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.14 T335839_1 - 1.6e-20 73.2 0.0 3.1e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain DUF1965 PF09248.8 T335839_1 - 0.00022 20.8 0.0 0.0006 19.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) E1-E2_ATPase PF00122.18 T023394_1 - 4.4e-48 163.4 1.2 6.9e-48 162.7 1.2 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 T023394_1 - 3.1e-37 127.9 0.2 3.1e-37 127.9 0.2 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 T023394_1 - 1.7e-18 66.4 0.2 2e-11 43.7 0.1 2.3 2 0 0 2 2 2 2 Cation transport ATPase (P-type) Hydrolase PF00702.24 T023394_1 - 3.3e-16 60.1 0.2 8e-14 52.3 0.2 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 T023394_1 - 0.00023 20.8 1.4 0.0094 15.6 0.4 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Calsequestrin PF01216.15 T023394_2 - 2.4e-240 797.0 22.6 2.9e-240 796.7 22.6 1.1 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.4 T023394_2 - 5.5e-21 75.2 7.3 1.6e-17 63.9 3.3 2.5 2 1 1 3 3 3 2 Thioredoxin-like domain VWA_N PF08399.9 T243792_2 - 3.4e-18 66.2 0.2 5.7e-18 65.4 0.2 1.3 1 0 0 1 1 1 1 VWA N-terminal VWA_3 PF13768.4 T243792_2 - 1.6e-14 53.9 0.0 2.4e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.16 T243792_2 - 2.5e-13 50.3 0.2 6.8e-12 45.6 0.0 2.2 2 0 0 2 2 2 1 Cache domain VWA PF00092.26 T243792_2 - 1.7e-11 44.6 0.1 2.6e-11 44.0 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 T243792_2 - 5.7e-09 36.5 0.1 8.9e-09 35.8 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_2 PF08269.9 T243792_2 - 0.0011 18.1 0.0 0.0054 15.8 0.0 1.8 2 0 0 2 2 2 1 Cache domain VWA_CoxE PF05762.12 T243792_2 - 0.032 13.5 0.0 0.051 12.8 0.0 1.2 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Cache_3-Cache_2 PF17201.2 T243792_2 - 0.062 12.4 0.0 0.14 11.2 0.0 1.5 2 0 0 2 2 2 0 Cache 3/Cache 2 fusion domain VGCC_alpha2 PF08473.9 T243792_3 - 2e-37 128.9 1.3 3e-37 128.3 1.3 1.2 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd TPR_2 PF07719.15 T175461_1 - 3.9e-05 23.3 1.5 0.00015 21.5 0.5 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.26 T175461_1 - 0.0004 20.0 0.7 0.0036 16.9 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.4 T175461_1 - 0.0014 19.1 0.1 0.0041 17.7 0.1 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.4 T175461_1 - 0.0029 18.0 0.6 0.0059 17.0 0.6 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.4 T175461_1 - 0.0095 16.5 0.2 0.026 15.1 0.2 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 T175461_1 - 0.014 15.3 2.7 0.13 12.2 0.3 2.3 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.4 T175461_1 - 0.04 14.1 0.9 0.072 13.3 0.9 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Sec16_C PF12931.5 T025636_3 - 8.5e-47 160.1 0.0 1.5e-46 159.3 0.0 1.4 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.5 T025636_3 - 7.7e-06 26.4 0.0 1.7e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region E7 PF00527.16 T025636_3 - 2 8.5 3.9 0.74 9.9 0.2 2.1 2 0 0 2 2 2 0 E7 protein, Early protein TNF PF00229.16 T365370_1 - 2.6e-22 79.0 0.7 3.9e-22 78.4 0.7 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family PPR_2 PF13041.4 T193304_2 - 2.4e-19 69.1 0.6 1.2e-08 34.8 0.2 4.6 4 0 0 4 4 4 3 PPR repeat family PPR_3 PF13812.4 T193304_2 - 4e-12 45.9 1.4 4.1e-07 29.9 0.0 3.0 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR_long PF17177.2 T193304_2 - 2.4e-06 26.9 0.0 4.5e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PROPR PPR PF01535.18 T193304_2 - 0.0024 17.8 2.2 0.2 11.9 0.1 4.4 4 0 0 4 4 4 1 PPR repeat PPR_1 PF12854.5 T193304_2 - 0.0089 15.6 0.0 14 5.4 0.0 4.1 6 0 0 6 6 6 2 PPR repeat RPM2 PF08579.9 T193304_2 - 0.01 16.1 0.3 0.018 15.2 0.3 1.3 1 0 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) AKAP2_C PF15304.4 T165322_2 - 1.3e-160 534.3 10.1 1.3e-160 534.3 10.1 3.1 3 0 0 3 3 3 2 A-kinase anchor protein 2 C-terminus Paralemmin PF03285.13 T165322_2 - 4.7e-127 423.8 8.7 9e-127 422.9 8.7 1.5 1 0 0 1 1 1 1 Paralemmin ERM PF00769.17 T165322_2 - 0.066 12.9 11.7 0.15 11.7 11.7 1.5 1 0 0 1 1 1 0 Ezrin/radixin/moesin family CoA_trans PF01144.21 T008660_1 - 4.1e-119 395.6 0.1 8.1e-73 244.3 0.0 2.2 2 0 0 2 2 2 2 Coenzyme A transferase TGFb_propeptide PF00688.16 T008660_1 - 1.9e-57 194.7 0.0 3.1e-54 184.2 0.0 2.2 2 0 0 2 2 2 2 TGF-beta propeptide TGF_beta PF00019.18 T008660_1 - 1.2e-34 119.2 2.3 2.3e-34 118.3 2.3 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain AcetylCoA_hyd_C PF13336.4 T008660_1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain I-set PF07679.14 T274307_3 - 1e-14 54.2 0.0 1.7e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T274307_3 - 4.1e-13 49.6 0.0 8.9e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T274307_3 - 1.3e-08 34.7 0.1 2.9e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T274307_3 - 7.2e-08 32.5 0.0 1.4e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 T274307_3 - 0.00043 20.3 0.0 0.00091 19.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Toxin_18 PF08087.9 T274307_3 - 0.055 13.3 0.1 0.16 11.8 0.1 1.8 1 0 0 1 1 1 0 Conotoxin O-superfamily CAP PF00188.24 T358044_1 - 6.8e-21 75.3 0.8 1.2e-20 74.5 0.8 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family BTB PF00651.29 T358044_3 - 6.5e-22 77.7 0.1 1.2e-21 76.9 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.23 T358044_3 - 5.1e-21 73.9 0.6 2.6e-06 26.8 0.0 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.4 T358044_3 - 1.4e-20 72.7 5.9 6.1e-08 32.5 0.1 5.5 3 2 2 5 5 5 3 Kelch motif Kelch_4 PF13418.4 T358044_3 - 1.7e-15 56.6 1.8 4.3e-06 26.4 0.1 5.0 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_2 PF07646.13 T358044_3 - 6e-10 38.6 0.2 0.0036 17.1 0.1 3.8 3 0 0 3 3 3 3 Kelch motif BACK PF07707.13 T358044_3 - 8e-10 38.6 0.0 1.6e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 T358044_3 - 1.1e-09 38.2 0.7 1.5e-05 25.0 0.1 4.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.4 T358044_3 - 0.059 13.2 2.5 14 5.7 0.5 3.2 3 0 0 3 3 3 0 Kelch motif Endostatin PF06482.9 T363695_3 - 4.2e-102 341.2 0.0 1.8e-100 335.9 0.0 2.1 1 1 0 1 1 1 1 Collagenase NC10 and Endostatin Collagen PF01391.16 T363695_3 - 4.9e-47 157.4 242.4 2.8e-08 33.3 35.0 11.0 7 3 2 9 9 9 9 Collagen triple helix repeat (20 copies) Laminin_G_3 PF13385.4 T363695_3 - 1.5e-06 28.3 0.0 2.6e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PS_Dcarbxylase PF02666.13 T232401_3 - 1.4e-67 227.0 0.0 2e-67 226.5 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase DHR-2 PF06920.11 T208753_3 - 1.4e-213 710.2 9.5 3.5e-213 708.9 9.5 1.7 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.4 T208753_3 - 9.7e-55 185.2 0.6 9.7e-55 185.2 0.6 2.5 2 1 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 T208753_3 - 1.7e-34 117.9 0.4 4.8e-34 116.5 0.4 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.27 T208753_3 - 6e-13 49.1 0.3 2.6e-12 47.0 0.3 2.2 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 T208753_3 - 0.0013 18.9 0.0 0.0063 16.7 0.0 2.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_10 PF15411.4 T208753_3 - 0.031 14.4 0.0 0.09 12.9 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain CCDC84 PF14968.4 T208753_3 - 0.044 13.3 0.4 5.9 6.3 0.0 2.7 2 0 0 2 2 2 0 Coiled coil protein 84 BTB PF00651.29 T105889_1 - 4.2e-19 68.7 1.5 8.3e-19 67.7 1.5 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 T105889_1 - 0.00071 19.8 2.8 0.00071 19.8 2.8 5.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 T105889_1 - 0.025 14.9 34.4 0.2 12.1 0.1 6.7 6 0 0 6 6 6 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 T105889_1 - 0.044 14.0 0.2 0.044 14.0 0.2 4.9 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 T105889_1 - 0.58 11.0 40.7 0.48 11.3 0.5 6.9 6 0 0 6 6 6 0 C2H2-type zinc finger CpXC PF14353.4 T105889_1 - 0.77 9.7 13.1 1.8 8.5 1.9 3.9 3 1 1 4 4 4 0 CpXC protein Period_C PF12114.6 T002492_1 - 1.8e-35 122.2 4.6 1.8e-35 122.2 4.6 2.4 3 0 0 3 3 3 1 Period protein 2/3C-terminal region DUF2457 PF10446.7 T321217_2 - 2.8 6.9 4.0 4.1 6.3 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) 7tm_2 PF00002.22 T321217_3 - 1.1e-92 309.6 18.0 1.8e-92 308.9 18.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 T321217_3 - 5.2e-26 90.6 1.3 5.2e-26 90.6 1.3 2.2 2 0 0 2 2 2 1 Hormone receptor domain zf-H2C2_2 PF13465.4 T323832_1 - 6.8e-15 54.6 30.8 1.3e-05 25.3 0.2 5.6 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 T323832_1 - 6.7e-06 26.1 59.8 0.00011 22.4 0.4 7.8 8 0 0 8 8 8 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T323832_1 - 0.00024 21.5 41.7 0.0024 18.4 0.4 7.8 6 0 0 6 6 6 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T323832_1 - 0.063 12.9 0.1 0.063 12.9 0.1 4.6 4 0 0 4 4 4 0 C2H2-type zinc-finger domain Collagen PF01391.16 T323832_1 - 1 9.0 7.1 3.8 7.2 7.1 2.0 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Pkinase PF00069.23 T240359_3 - 1.9e-29 102.7 0.0 3e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T240359_3 - 4.4e-24 85.0 0.0 6e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.21 T240359_3 - 4.1e-08 34.0 13.2 1.1e-07 32.7 13.2 1.8 1 0 0 1 1 1 1 Activin types I and II receptor domain zf-RING_2 PF13639.4 T273078_3 - 6.3e-05 23.0 5.8 6.3e-05 23.0 5.8 2.8 3 0 0 3 3 2 1 Ring finger domain zf-rbx1 PF12678.5 T273078_3 - 0.00037 20.6 5.3 0.00037 20.6 5.3 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 T273078_3 - 0.0027 17.4 6.2 0.0027 17.4 6.2 2.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T273078_3 - 0.0054 16.4 2.6 0.0054 16.4 2.6 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 T273078_3 - 0.013 15.4 0.8 0.013 15.4 0.8 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 T273078_3 - 0.013 15.1 1.9 0.072 12.7 1.9 2.4 1 0 0 1 1 1 0 RING-like zinc finger DZR PF12773.5 T273078_3 - 0.059 13.3 5.9 0.6 10.0 1.7 2.6 2 0 0 2 2 2 0 Double zinc ribbon Prok-RING_4 PF14447.4 T273078_3 - 0.15 11.8 4.3 0.41 10.4 4.3 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Cys_rich_CPXG PF14255.4 T273078_3 - 0.24 11.2 2.2 13 5.7 0.4 2.5 2 0 0 2 2 2 0 Cysteine-rich CPXCG zf-RING_5 PF14634.4 T273078_3 - 1.6 8.6 16.3 0.03 14.1 6.2 3.0 2 0 0 2 2 2 0 zinc-RING finger domain zf-ribbon_3 PF13248.4 T273078_3 - 1.9 7.9 5.4 19 4.7 0.2 3.4 3 0 0 3 3 3 0 zinc-ribbon domain FANCL_C PF11793.6 T273078_3 - 4.2 7.5 7.2 23 5.1 7.2 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain GPR_Gpa2_C PF11970.6 T086639_3 - 0.019 14.9 0.1 0.056 13.4 0.1 1.8 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term Fumarate_red_C PF02300.15 T086639_3 - 0.33 10.9 3.8 2 8.4 1.7 2.2 2 0 0 2 2 2 0 Fumarate reductase subunit C Cadherin PF00028.15 T262917_3 - 1.7e-105 345.6 6.9 9.5e-20 70.7 0.1 8.3 8 0 0 8 8 8 8 Cadherin domain Protocadherin PF08374.9 T262917_3 - 3e-88 295.3 4.2 6.1e-88 294.3 4.2 1.5 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.10 T262917_3 - 3.2e-15 55.6 0.6 1e-06 28.3 0.0 4.7 5 0 0 5 5 5 3 Cadherin-like TMEM154 PF15102.4 T262917_3 - 0.0031 17.3 0.2 0.0062 16.3 0.2 1.4 1 0 0 1 1 1 1 TMEM154 protein family Mid2 PF04478.10 T262917_3 - 0.023 14.4 0.2 0.054 13.2 0.2 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Cadherin_pro PF08758.9 T262917_3 - 0.027 14.5 0.0 0.1 12.7 0.0 1.9 2 0 0 2 2 2 0 Cadherin prodomain like DUF1510 PF07423.9 T262917_3 - 0.042 13.2 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Adeno_E3_CR2 PF02439.13 T262917_3 - 0.26 11.0 3.6 0.77 9.4 3.6 1.8 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF3827 PF12877.5 T262917_3 - 3.7 5.7 7.2 0.21 9.8 0.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3827) RYDR_ITPR PF01365.19 T114032_1 - 2.5e-137 454.7 8.5 1.5e-73 246.5 0.0 2.6 2 0 0 2 2 2 2 RIH domain RyR PF02026.14 T114032_1 - 1.5e-123 403.1 2.0 2.8e-33 113.8 0.0 4.7 4 0 0 4 4 4 4 RyR domain SPRY PF00622.26 T114032_1 - 4.6e-65 217.0 0.6 4.7e-20 71.8 0.0 3.7 3 0 0 3 3 3 3 SPRY domain MIR PF02815.17 T114032_1 - 3.8e-60 202.8 0.1 4.4e-55 186.3 0.0 2.3 2 0 0 2 2 2 2 MIR domain Ins145_P3_rec PF08709.9 T114032_1 - 5.1e-59 198.9 0.0 1.8e-56 190.6 0.0 3.2 2 1 1 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RIH_assoc PF08454.9 T114032_2 - 2.3e-30 104.3 0.2 5.1e-30 103.2 0.2 1.6 1 0 0 1 1 1 1 RyR and IP3R Homology associated RR_TM4-6 PF06459.10 T114032_3 - 2.4e-57 194.8 21.4 3.2e-31 109.1 7.5 3.0 2 1 1 3 3 3 2 Ryanodine Receptor TM 4-6 Ion_trans PF00520.29 T114032_3 - 9.5e-14 51.1 3.0 9.5e-14 51.1 3.0 2.0 3 0 0 3 3 3 1 Ion transport protein EF-hand_1 PF00036.30 T114032_3 - 0.00014 21.0 0.1 0.00028 20.1 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 T114032_3 - 0.0019 17.8 0.4 0.0043 16.7 0.4 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T114032_3 - 0.0019 17.9 0.0 0.0053 16.5 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.4 T114032_3 - 0.076 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.4 T114032_3 - 0.2 12.0 6.0 0.022 15.1 1.2 1.9 2 0 0 2 2 2 0 EF-hand domain pair CbbQ_C PF08406.8 T243112_1 - 0.22 11.6 0.9 0.41 10.8 0.9 1.3 1 0 0 1 1 1 0 CbbQ/NirQ/NorQ C-terminal 7tm_3 PF00003.20 T243112_3 - 1.2e-66 224.7 14.4 1.7e-66 224.3 14.4 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 T243112_3 - 4e-15 55.6 0.0 5.4e-15 55.2 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 T243112_3 - 6.5e-13 48.3 10.8 1.9e-12 46.8 10.8 1.9 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Hemopexin PF00045.17 T026584_1 - 3.7e-14 52.3 3.3 1.5e-09 37.5 0.2 3.3 3 0 0 3 3 3 2 Hemopexin Somatomedin_B PF01033.15 T026584_1 - 1.3e-10 41.4 17.9 3e-10 40.2 17.9 1.7 1 0 0 1 1 1 1 Somatomedin B domain CPCFC PF17223.1 T026584_3 - 0.079 12.6 30.7 1.5 8.5 0.5 6.7 5 0 0 5 5 5 0 Cuticle protein CPCFC Ion_trans PF00520.29 T053923_1 - 3.6e-26 91.7 6.2 5.4e-26 91.2 6.2 1.2 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.3 T053923_1 - 1.7e-20 73.0 6.5 1.7e-20 73.0 6.5 1.8 2 0 0 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.27 T053923_1 - 8.1e-18 64.1 0.0 1.5e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain BEN PF10523.7 T264009_1 - 3.1e-14 52.8 0.0 7.1e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 BEN domain bZIP_1 PF00170.19 T264009_1 - 0.08 12.9 0.2 0.15 12.1 0.2 1.4 1 0 0 1 1 1 0 bZIP transcription factor Shugoshin_N PF07558.9 T264009_1 - 0.14 11.9 1.6 0.27 11.0 1.6 1.4 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region DUF4686 PF15742.3 T264009_1 - 0.36 9.8 1.4 0.56 9.1 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) bZIP_2 PF07716.13 T264009_1 - 0.53 10.3 3.9 0.99 9.4 3.9 1.4 1 0 0 1 1 1 0 Basic region leucine zipper NTP_transferase PF00483.21 T208179_1 - 9.1e-09 35.1 0.0 1.4e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase I-set PF07679.14 T208179_2 - 1e-144 470.9 0.0 1.7e-21 76.0 0.0 8.8 9 0 0 9 9 9 8 Immunoglobulin I-set domain Pkinase PF00069.23 T208179_2 - 3e-103 344.6 0.0 2.1e-51 174.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 T208179_2 - 1.2e-81 269.3 0.0 1.8e-10 41.1 0.0 9.0 8 0 0 8 8 8 8 Immunoglobulin domain Pkinase_Tyr PF07714.15 T208179_2 - 3.2e-48 164.2 0.0 7.3e-25 87.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Ig_2 PF13895.4 T208179_2 - 2.4e-47 159.0 0.0 8.3e-07 29.1 0.0 8.4 8 0 0 8 8 8 8 Immunoglobulin domain ig PF00047.23 T208179_2 - 5.2e-41 138.6 0.0 0.00019 21.4 0.0 9.5 9 0 0 9 9 9 7 Immunoglobulin domain SPEG_u2 PF16650.3 T208179_2 - 4.4e-31 106.7 14.4 4.4e-31 106.7 14.4 2.7 2 0 0 2 2 2 1 Unstructured region on SPEG complex protein V-set PF07686.15 T208179_2 - 3.7e-11 43.0 0.1 0.1 12.6 0.0 7.4 7 2 0 7 7 7 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 T208179_2 - 1.2e-08 34.7 0.0 3.1 7.8 0.0 6.8 6 0 0 6 6 6 2 CD80-like C2-set immunoglobulin domain fn3 PF00041.19 T208179_2 - 7.7e-08 32.5 0.2 0.015 15.5 0.1 2.6 2 0 0 2 2 2 2 Fibronectin type III domain Kdo PF06293.12 T208179_2 - 0.023 13.9 0.7 0.054 12.7 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Izumo-Ig PF16706.3 T208179_2 - 0.027 14.4 2.4 2.9 7.9 0.1 4.3 6 0 0 6 6 5 0 Izumo-like Immunoglobulin domain Kinase-like PF14531.4 T208179_2 - 0.18 10.9 0.0 0.4 9.8 0.0 1.5 1 0 0 1 1 1 0 Kinase-like ASC PF00858.22 T208179_3 - 5.4e-92 308.7 0.0 7.8e-92 308.2 0.0 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel I-set PF07679.14 T208179_3 - 1.6e-35 120.9 0.0 6.3e-18 64.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 T208179_3 - 3.7e-21 75.4 0.0 1.8e-10 41.2 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 T208179_3 - 1.4e-12 47.6 0.0 0.00025 21.2 0.0 4.2 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.23 T208179_3 - 6.8e-11 42.1 0.0 3.6e-06 26.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain NTP_transferase PF00483.21 T208179_3 - 9.1e-09 35.1 0.0 1.4e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.22 T208179_3 - 9.2e-06 25.0 1.4 5.8e-05 22.5 0.3 2.7 3 0 0 3 3 3 1 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.3 T208179_3 - 0.28 9.1 0.1 0.39 8.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) FXa_inhibition PF14670.4 T025556_1 - 3.6e-08 33.4 3.8 3.6e-08 33.4 3.8 4.9 4 0 0 4 4 4 2 Coagulation Factor Xa inhibitory site Tme5_EGF_like PF09064.8 T025556_1 - 0.0019 17.9 2.8 0.0019 17.9 2.8 3.3 4 0 0 4 4 4 1 Thrombomodulin like fifth domain, EGF-like MACPF PF01823.17 T025556_1 - 0.041 13.8 0.1 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 MAC/Perforin domain UPF0560 PF10577.7 T025556_1 - 0.099 11.0 0.4 0.17 10.3 0.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Lustrin_cystein PF14625.4 T025556_1 - 8 6.8 21.5 2.1 8.7 0.2 4.9 4 0 0 4 4 4 0 Lustrin, cysteine-rich repeated domain 7tm_1 PF00001.19 T291747_3 - 1.6e-43 148.7 11.4 2.7e-43 148.0 11.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T291747_3 - 3.3e-06 26.5 11.8 7.5e-06 25.4 11.8 1.6 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 T291747_3 - 0.00012 21.8 5.8 0.00026 20.7 5.8 1.5 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 T291747_3 - 0.0046 16.2 16.1 0.0046 16.2 16.1 2.4 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx Rab5ip PF07019.10 T291747_3 - 0.2 12.1 0.1 0.2 12.1 0.1 3.1 4 0 0 4 4 4 0 Rab5-interacting protein (Rab5ip) RRM_1 PF00076.20 T294939_1 - 5.1e-08 32.5 0.0 2.7e-05 23.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF PF08080.10 T294939_3 - 1.8e-22 78.8 13.8 2.6e-22 78.3 12.5 2.0 2 0 0 2 2 2 1 RNPHF zinc finger RRM_1 PF00076.20 T294939_3 - 1.4e-08 34.3 0.0 2.5e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WASH_WAHD PF11945.6 T123941_1 - 1.3e-07 31.3 0.0 1.8e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 WAHD domain of WASH complex WASH_WAHD PF11945.6 T123941_2 - 5.3e-45 154.0 0.1 7.4e-45 153.6 0.1 1.1 1 0 0 1 1 1 1 WAHD domain of WASH complex WASH_WAHD PF11945.6 T123941_3 - 2.9e-29 102.4 0.0 4.4e-29 101.8 0.0 1.1 1 0 0 1 1 1 1 WAHD domain of WASH complex I-set PF07679.14 T027786_2 - 3.5e-18 65.3 0.0 5.2e-09 35.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 T027786_2 - 2.6e-07 31.0 0.0 0.00027 21.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 T027786_2 - 0.0018 18.3 0.0 0.0093 16.0 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 T027786_2 - 0.051 13.6 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ig_2 PF13895.4 T027786_2 - 0.052 13.8 0.0 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain HAP1_N PF04849.11 T240823_3 - 2.1e-134 447.4 39.4 2.8e-134 447.1 39.4 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Milton PF12448.6 T240823_3 - 6.2e-67 224.9 6.3 1.6e-66 223.6 6.3 1.8 1 0 0 1 1 1 1 Kinesin associated protein KASH_CCD PF14662.4 T240823_3 - 0.031 14.0 39.9 0.016 15.0 14.3 3.0 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH ATG16 PF08614.9 T240823_3 - 3.3 7.7 37.0 1.3 9.0 22.4 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Homeobox PF00046.27 T238347_2 - 7.4e-17 60.8 5.2 7.4e-17 60.8 5.2 2.1 1 1 1 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 T238347_2 - 0.0038 17.0 0.2 0.0079 15.9 0.2 1.5 1 0 0 1 1 1 1 Homeobox KN domain Ig_2 PF13895.4 T023228_1 - 6.7e-27 93.5 0.0 3e-08 33.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 T023228_1 - 5.2e-23 81.3 0.0 1.4e-08 35.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T023228_1 - 1.8e-14 53.5 0.0 6.5e-05 22.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T023228_1 - 7.7e-08 32.2 0.0 0.16 12.0 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_4 PF16680.3 T023228_1 - 4.8e-05 23.5 0.1 0.0089 16.2 0.0 3.2 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain V-set PF07686.15 T023228_1 - 0.0037 17.3 0.0 0.54 10.3 0.0 3.6 3 0 0 3 3 3 1 Immunoglobulin V-set domain Receptor_2B4 PF11465.6 T023228_1 - 0.022 14.8 0.0 0.59 10.2 0.0 2.4 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 AA_permease PF00324.19 T114106_2 - 1.7e-52 178.4 24.9 3.5e-40 137.9 6.3 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 T114106_2 - 1.7e-37 129.3 10.9 2.3e-17 63.0 0.1 3.2 1 1 1 2 2 2 2 Solute carrier family 12 Pkinase PF00069.23 T199903_1 - 2.4e-67 227.0 0.0 2.4e-65 220.4 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 T199903_1 - 1.2e-47 162.3 0.0 2.1e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T199903_1 - 3.2e-06 26.6 0.2 0.0001 21.6 0.0 2.9 2 1 1 3 3 3 1 Kinase-like APH PF01636.21 T199903_1 - 0.0052 16.6 0.0 0.069 12.9 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Ank_2 PF12796.5 T199903_2 - 0.00091 19.6 0.0 0.0019 18.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) DUF2475 PF10629.7 T357735_1 - 2.3e-14 53.2 0.6 2e-09 37.4 0.7 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) FAM165 PF14981.4 T357735_2 - 0.078 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 FAM165 family DUF2475 PF10629.7 T357735_3 - 1.6e-05 24.9 0.7 1.6e-05 24.9 0.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2475) IL23 PF16649.3 T080270_3 - 5.2e-97 322.2 1.2 7.1e-97 321.7 1.2 1.2 1 0 0 1 1 1 1 Interleukin 23 subunit alpha RhoGAP PF00620.25 T063485_2 - 5.1e-45 152.9 0.0 8e-45 152.2 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 T063485_2 - 1.3e-42 144.4 0.2 1.7e-12 47.7 0.0 5.3 5 0 0 5 5 5 4 PH domain ArfGap PF01412.16 T063485_2 - 2.6e-30 104.7 0.0 5.5e-30 103.7 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf RA PF00788.21 T063485_2 - 8e-12 45.5 0.0 1.5e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH_11 PF15413.4 T063485_2 - 2.3e-08 34.3 3.2 1.2 9.5 0.0 5.5 5 1 0 5 5 5 3 Pleckstrin homology domain PH_6 PF15406.4 T063485_2 - 2.4e-05 24.5 0.0 0.02 15.0 0.1 3.1 3 0 0 3 3 3 1 Pleckstrin homology domain PH_8 PF15409.4 T063485_2 - 0.0001 22.3 0.9 0.14 12.3 0.2 3.8 4 0 0 4 4 4 1 Pleckstrin homology domain PH_2 PF08458.8 T063485_2 - 0.0025 18.0 0.2 3.5 7.9 0.0 2.8 3 0 0 3 3 3 2 Plant pleckstrin homology-like region PH_13 PF16652.3 T063485_2 - 0.064 13.0 0.1 4.1 7.1 0.1 2.7 3 0 0 3 3 3 0 Pleckstrin homology domain MHC_II_beta PF00969.17 T301760_2 - 9.9e-33 112.0 0.2 1.8e-32 111.2 0.2 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 T301760_2 - 7.1e-26 90.4 0.1 1.6e-25 89.3 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ig PF00047.23 T301760_2 - 0.023 14.8 0.9 0.043 13.9 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin domain zf-H2C2_2 PF13465.4 T323824_3 - 3e-10 39.9 28.9 2.6e-05 24.3 3.9 5.6 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 T323824_3 - 2.2e-05 24.5 55.2 9.7e-05 22.5 0.4 6.9 7 0 0 7 7 7 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T323824_3 - 0.00016 22.1 37.1 0.0022 18.5 0.4 6.9 5 0 0 5 5 5 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T323824_3 - 0.058 13.0 0.1 0.058 13.0 0.1 4.6 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2HE PF16278.3 T323824_3 - 0.29 11.5 7.8 1.6 9.1 0.1 3.3 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger RRM_1 PF00076.20 T151124_2 - 1.1e-33 114.7 0.3 1.5e-16 59.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T151124_2 - 1e-09 38.2 0.1 0.0025 17.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 T151124_2 - 0.00025 20.8 0.1 0.57 10.0 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.4 T151124_2 - 0.041 14.0 0.0 2.5 8.2 0.1 2.2 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter NID PF07292.11 T151124_2 - 0.097 13.2 0.4 2.4 8.8 0.1 2.3 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) PAP2 PF01569.19 T168555_1 - 3.1e-14 52.8 2.6 5.5e-14 52.0 2.6 1.4 1 0 0 1 1 1 1 PAP2 superfamily TelA PF05816.9 T168555_2 - 0.0023 16.9 5.7 0.0034 16.4 5.7 1.2 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) Lectin_C PF00059.19 T072980_1 - 5.8e-19 68.7 2.3 1e-18 67.9 2.3 1.4 1 0 0 1 1 1 1 Lectin C-type domain KRAP_IP3R_bind PF14722.4 T321255_3 - 3.8e-69 230.9 0.0 7.8e-69 229.9 0.0 1.6 1 0 0 1 1 1 1 Ki-ras-induced actin-interacting protein-IP3R-interacting domain SSFA2_C PF14723.4 T321255_3 - 1.5e-15 57.4 0.4 3.5e-15 56.2 0.4 1.7 1 0 0 1 1 1 1 Sperm-specific antigen 2 C-terminus DUF1640 PF07798.9 T321255_3 - 0.34 10.8 7.8 0.05 13.5 3.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Lectin_N PF03954.12 T321255_3 - 0.5 10.0 3.0 1.4 8.5 3.0 1.8 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain BRCT PF00533.24 T148069_3 - 3.4e-19 68.9 0.1 4e-09 36.6 0.0 3.0 3 0 0 3 3 2 2 BRCA1 C Terminus (BRCT) domain zf-C3HC4 PF00097.23 T148069_3 - 1.2e-09 37.7 10.7 3.1e-09 36.4 10.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T148069_3 - 3.1e-09 36.4 11.1 8.7e-09 35.0 11.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T148069_3 - 9.5e-08 32.0 10.7 2.2e-07 30.8 10.7 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 T148069_3 - 2.6e-07 30.3 7.6 5.8e-07 29.2 7.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T148069_3 - 5.3e-07 29.4 9.0 1.6e-06 27.9 9.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 T148069_3 - 7e-07 29.3 8.6 1.8e-06 27.9 8.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 T148069_3 - 9.9e-06 25.3 8.7 2.3e-05 24.1 8.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.6 T148069_3 - 0.00014 21.5 7.4 0.00037 20.1 7.4 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 T148069_3 - 0.00023 20.8 2.1 0.00051 19.7 2.1 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein BRCT_2 PF16589.3 T148069_3 - 0.00025 21.2 0.0 0.21 11.9 0.0 2.6 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain Prok-RING_4 PF14447.4 T148069_3 - 0.00069 19.3 7.3 0.0023 17.6 7.3 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 T148069_3 - 0.0015 18.4 1.7 0.0032 17.3 1.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.3 T148069_3 - 0.0035 17.3 7.0 0.0076 16.2 7.0 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.5 T148069_3 - 0.01 16.0 4.7 0.026 14.7 4.7 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.4 T148069_3 - 0.43 10.2 7.1 1.2 8.7 7.1 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF1443 PF07280.9 T013446_2 - 0.021 14.4 0.4 0.021 14.4 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1443) Glyco_transf_29 PF00777.16 T013446_3 - 1.1e-30 106.9 1.6 1.6e-30 106.3 1.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) 7tm_2 PF00002.22 T007137_2 - 1.1e-62 211.4 12.9 1.5e-62 211.0 12.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) TSP_1 PF00090.17 T007137_2 - 1.3e-38 130.9 67.6 1.1e-11 44.6 8.4 5.2 4 0 0 4 4 4 4 Thrombospondin type 1 domain GAIN PF16489.3 T007137_2 - 2.2e-36 125.2 0.0 3.2e-36 124.6 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.19 T007137_2 - 2e-12 47.4 4.5 8.7e-12 45.4 4.5 2.3 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_1 PF00001.19 T007137_2 - 0.00087 18.5 0.0 0.0015 17.7 0.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Tubulin PF00091.23 T158963_1 - 9.4e-69 231.4 0.0 1.4e-68 230.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 T158963_1 - 2.2e-40 137.7 0.1 3.3e-40 137.1 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 T158963_1 - 9e-05 22.6 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.4 T158963_1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.4 T158963_1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain zf-Tim10_DDP PF02953.13 T377745_2 - 6e-22 76.9 1.4 1.1e-21 76.2 1.4 1.4 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Pkinase_Tyr PF07714.15 T377745_3 - 1.5e-93 312.7 0.2 2e-93 312.3 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T377745_3 - 4.1e-46 157.3 0.1 5.6e-46 156.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 T377745_3 - 1.1e-20 73.3 0.1 2.1e-20 72.4 0.1 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 T377745_3 - 4.4e-16 58.1 0.1 8.5e-16 57.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain BTK PF00779.17 T377745_3 - 2.4e-12 46.3 1.8 5.3e-12 45.2 1.8 1.7 1 0 0 1 1 1 1 BTK motif PH PF00169.27 T377745_3 - 1.7e-11 44.4 0.9 5.3e-11 42.8 0.1 2.3 3 0 0 3 3 3 1 PH domain SH3_9 PF14604.4 T377745_3 - 3.3e-08 33.1 0.1 6.5e-08 32.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T377745_3 - 4.1e-05 23.1 0.0 8.9e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Kinase-like PF14531.4 T377745_3 - 0.002 17.3 0.0 0.0035 16.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like SH3_3 PF08239.9 T377745_3 - 0.0023 18.0 0.1 0.0048 17.0 0.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain APH PF01636.21 T377745_3 - 0.15 11.8 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 T377745_3 - 0.16 11.2 0.1 0.27 10.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family 7tm_1 PF00001.19 T005360_3 - 1.6e-75 253.7 11.8 2.4e-75 253.1 11.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T005360_3 - 1.1e-07 31.4 11.0 1.9e-07 30.6 11.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 T005360_3 - 0.00041 20.0 11.7 0.0044 16.7 9.4 2.6 2 1 0 2 2 2 1 Olfactory receptor CarboxypepD_reg PF13620.4 T128104_1 - 4.2e-30 103.7 9.7 1.5e-08 34.7 0.5 7.9 7 1 0 7 7 7 4 Carboxypeptidase regulatory-like domain SdrD_B PF17210.1 T128104_1 - 1.6e-20 73.2 1.4 1.6e-05 25.0 0.0 7.4 7 1 1 8 8 7 3 SdrD B-like domain DUF2012 PF09430.8 T128104_1 - 6.7e-20 71.3 0.2 5.7e-07 29.5 0.0 5.9 6 0 0 6 6 6 4 Protein of unknown function (DUF2012) CarbopepD_reg_2 PF13715.4 T128104_1 - 7.4e-15 54.6 5.1 5.5e-05 22.9 0.3 6.8 7 0 0 7 7 7 3 CarboxypepD_reg-like domain fn3_3 PF14686.4 T128104_1 - 1.7e-11 43.6 0.2 0.043 13.4 0.0 6.2 6 0 0 6 6 6 3 Polysaccharide lyase family 4, domain II DUF1416 PF07210.10 T128104_1 - 2.5e-06 27.1 0.4 0.17 11.6 0.0 4.6 5 0 0 5 5 5 2 Protein of unknown function (DUF1416) DUF3823 PF12866.5 T128104_1 - 8.6e-05 22.3 0.2 0.76 9.4 0.0 4.1 5 0 0 5 5 5 2 Protein of unknown function (DUF3823) DUF4198 PF10670.7 T128104_1 - 0.00041 20.7 0.2 4.6 7.4 0.1 4.6 5 0 0 5 5 5 1 Domain of unknown function (DUF4198) Y_Y_Y PF07495.11 T128104_1 - 0.00054 19.7 2.5 7.5 6.5 0.0 5.1 5 0 0 5 5 5 1 Y_Y_Y domain Big_3 PF07523.10 T128104_1 - 0.0026 17.9 0.3 21 5.4 0.0 5.4 6 0 0 6 6 5 0 Bacterial Ig-like domain (group 3) TTR-52 PF01060.21 T128104_1 - 0.005 17.4 0.1 24 5.6 0.0 4.7 6 0 0 6 6 5 0 Transthyretin-like family MetallophosN PF16371.3 T128104_1 - 0.082 13.0 1.5 16 5.7 0.0 4.0 4 0 0 4 4 4 0 N terminal of Calcineurin-like phosphoesterase DUF2141 PF09912.7 T128104_1 - 0.094 12.5 0.2 4.6 7.1 0.0 3.5 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2141) FlaC_arch PF05377.9 T195080_1 - 0.00027 21.1 2.1 0.00027 21.1 2.1 9.8 8 3 4 12 12 12 2 Flagella accessory protein C (FlaC) ERM PF00769.17 T195080_1 - 0.0016 18.2 21.8 0.0016 18.2 21.8 6.3 1 1 5 6 6 6 2 Ezrin/radixin/moesin family DUF2316 PF10078.7 T195080_1 - 1.6 8.9 9.7 13 6.0 4.5 3.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) Pox_A3L PF05288.9 T195080_1 - 9.8 6.1 13.9 0.14 12.0 0.2 4.0 4 0 0 4 4 4 0 Poxvirus A3L Protein THRAP3_BCLAF1 PF15440.4 T372182_3 - 1.1e-195 652.5 58.6 1.4e-195 652.0 58.6 1.1 1 0 0 1 1 1 1 THRAP3/BCLAF1 family MACPF PF01823.17 T281323_1 - 3.1e-32 112.2 0.1 5.5e-32 111.4 0.1 1.4 1 0 0 1 1 1 1 MAC/Perforin domain Ldl_recept_a PF00057.16 T281323_1 - 4.4e-09 36.3 15.3 4.4e-09 36.3 15.3 2.0 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A PID PF00640.21 T281323_1 - 1.5e-07 31.4 0.0 2.8e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) TSP_1 PF00090.17 T281323_1 - 4.3e-05 23.5 5.4 0.00018 21.5 5.4 2.2 1 0 0 1 1 1 1 Thrombospondin type 1 domain PAH PF02671.19 T022196_3 - 4.7e-10 39.3 5.6 2.9e-06 27.2 0.7 3.4 3 0 0 3 3 3 2 Paired amphipathic helix repeat Myb_DNA-bind_6 PF13921.4 T022196_3 - 3e-05 24.0 0.1 0.00062 19.8 0.0 3.1 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.29 T022196_3 - 0.024 14.6 0.0 0.11 12.6 0.0 2.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain CtnDOT_TraJ PF07863.9 T022196_3 - 0.094 13.2 0.2 0.23 12.0 0.2 1.6 1 0 0 1 1 1 0 Homologues of TraJ from Bacteroides conjugative transposon DUF2789 PF10982.6 T022196_3 - 0.39 10.8 3.0 1.1 9.3 3.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2789) SAM_1 PF00536.28 T075792_2 - 1.2e-37 128.1 10.4 5.6e-17 61.8 0.2 3.9 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T075792_2 - 3.5e-32 110.2 5.8 9.7e-14 51.1 0.0 3.8 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) DUF16 PF01519.14 T075792_2 - 0.0012 19.2 1.4 0.0012 19.2 1.4 2.8 2 1 0 2 2 2 1 Protein of unknown function DUF16 SAM_PNT PF02198.14 T075792_2 - 0.042 13.7 2.2 3.8 7.4 0.1 3.0 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain ADIP PF11559.6 T075792_2 - 0.46 10.4 22.6 0.19 11.7 8.6 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.4 T075792_2 - 0.7 9.0 14.8 8.3 5.5 13.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF3837 PF12939.5 T075792_2 - 4.7 7.5 11.2 0.042 14.1 1.0 2.8 3 1 1 4 4 4 0 Domain of unknown function (DUF3837) Peptidase_C2 PF00648.19 T304333_2 - 6.6e-126 419.2 0.0 9e-126 418.7 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 T304333_2 - 1.5e-50 171.1 0.0 2.3e-50 170.4 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 T304333_2 - 3.3e-10 38.6 0.2 0.0009 18.5 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 T304333_2 - 5.2e-08 32.4 2.4 2.9e-06 26.8 0.1 3.4 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.4 T304333_2 - 1.1e-06 28.0 0.1 0.022 14.6 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 T304333_2 - 0.00055 20.2 2.2 0.16 12.4 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 T304333_2 - 0.16 11.4 0.1 2.8 7.5 0.1 2.5 2 0 0 2 2 2 0 EF hand Neurexophilin PF06312.10 T150123_1 - 1.3e-92 308.9 0.1 1.8e-92 308.4 0.1 1.1 1 0 0 1 1 1 1 Neurexophilin RGS PF00615.17 T124106_2 - 9.7e-32 109.6 0.0 1.3e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain G-gamma PF00631.20 T124106_2 - 8.5e-10 38.4 0.0 2.1e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 GGL domain DEP PF00610.19 T124106_3 - 1.8e-15 56.6 0.0 2.7e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) 7tm_1 PF00001.19 T272647_1 - 3.7e-25 88.6 8.9 6.6e-25 87.7 8.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Med21 PF11221.6 T075698_2 - 4.9e-25 88.3 1.5 7.4e-25 87.7 1.5 1.3 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Pro_racemase PF05544.9 T105278_2 - 3.6e-61 206.9 0.1 7.8e-51 172.9 0.0 2.1 2 0 0 2 2 2 2 Proline racemase Pro_racemase PF05544.9 T105278_3 - 4.3e-46 157.3 0.0 6.2e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 Proline racemase 7tm_1 PF00001.19 T105278_3 - 6e-39 133.8 6.6 1e-38 133.0 6.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dickkopf_N PF04706.10 T269186_2 - 9.6e-15 54.7 37.7 1.3e-14 54.2 20.5 2.9 2 1 0 2 2 2 2 Dickkopf N-terminal cysteine-rich region Sec16_C PF12931.5 T047184_1 - 0.00045 19.8 0.1 0.0059 16.1 0.1 2.0 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 NDUF_B8 PF05821.9 T047184_2 - 7.1e-75 250.6 6.6 1e-74 250.2 6.6 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) ANAPC4_WD40 PF12894.5 T047184_3 - 0.0031 17.7 0.3 0.82 9.9 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 T047184_3 - 0.0082 16.9 0.3 1.7 9.5 0.0 4.0 3 0 0 3 3 3 1 WD domain, G-beta repeat G_glu_transpept PF01019.19 T216626_1 - 2.5e-57 194.7 0.0 2.9e-45 154.9 0.0 2.1 2 0 0 2 2 2 2 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.19 T216626_3 - 8e-73 245.8 0.0 1e-72 245.4 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase SP_C-Propep PF08999.8 T216626_3 - 0.49 10.1 2.1 1 9.0 2.1 1.4 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide RNase_Zc3h12a PF11977.6 T101849_3 - 2.5e-51 173.4 0.0 3.6e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain rve PF00665.24 T101849_3 - 0.077 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Ion_trans PF00520.29 T234064_2 - 1.4e-120 400.9 32.5 2.2e-64 216.9 13.3 2.2 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.10 T234064_2 - 9.8e-14 50.7 35.7 1.9e-08 33.3 3.4 5.1 3 1 1 4 4 4 4 Polycystin cation channel GRP PF07172.9 T234064_2 - 0.12 13.0 0.4 0.38 11.3 0.1 1.9 2 0 0 2 2 2 0 Glycine rich protein family Myosin_head PF00063.19 T146095_1 - 6.1e-193 642.6 0.0 7.9e-193 642.2 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.25 T146095_1 - 0.0054 16.3 1.9 0.0054 16.3 1.9 3.4 3 0 0 3 3 3 2 IQ calmodulin-binding motif AAA_22 PF13401.4 T146095_1 - 0.013 15.7 0.0 0.035 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 T146095_1 - 0.014 15.6 1.2 0.072 13.3 0.0 2.8 4 0 0 4 4 4 0 AAA ATPase domain MGTL PF17059.3 T231349_1 - 0.17 11.6 5.2 1 9.1 5.2 2.4 1 0 0 1 1 1 0 MgtA leader peptide NARP1 PF12569.6 T093467_1 - 5.2e-82 276.3 1.2 5.2e-82 276.3 1.2 1.4 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.15 T093467_1 - 3.2e-08 32.9 0.9 0.057 13.4 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 T093467_1 - 0.00041 19.9 1.7 1.4 8.7 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 T093467_1 - 0.0005 20.5 0.0 3.3 8.6 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.4 T093467_1 - 0.0022 18.0 6.8 0.01 15.9 0.4 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.4 T093467_1 - 0.0081 16.7 0.1 0.046 14.3 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.5 T093467_1 - 0.065 13.3 0.5 0.14 12.2 0.1 1.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 T093467_1 - 0.11 12.8 0.1 0.36 11.2 0.1 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.4 T093467_1 - 0.51 10.5 2.5 24 5.2 0.1 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat NARP1 PF12569.6 T093467_3 - 3.4e-103 346.1 30.6 1.6e-69 235.1 16.1 2.7 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.15 T093467_3 - 3e-10 39.3 8.2 7.5e-05 22.4 0.1 5.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.4 T093467_3 - 1.3e-09 37.5 0.4 1.4e-05 24.5 0.1 3.9 3 0 0 3 3 3 1 TPR repeat TPR_8 PF13181.4 T093467_3 - 1.8e-09 37.0 11.1 0.00046 20.1 0.2 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.26 T093467_3 - 1.8e-08 33.7 15.0 3.5e-05 23.3 0.6 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.4 T093467_3 - 4.9e-08 33.0 0.0 0.15 12.8 0.0 6.0 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.4 T093467_3 - 7.8e-07 29.4 4.0 0.042 14.2 0.3 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_15 PF13429.4 T093467_3 - 3.5e-06 26.3 2.0 1e-05 24.8 1.9 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.5 T093467_3 - 2.5e-05 24.2 8.6 0.00063 19.8 0.5 3.9 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.4 T093467_3 - 0.00012 22.2 3.6 2.2 8.5 0.1 4.5 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.4 T093467_3 - 0.0023 18.4 0.5 1.5 9.4 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 T093467_3 - 0.0028 17.4 3.5 0.049 13.6 0.1 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_6 PF13174.4 T093467_3 - 0.014 15.8 2.6 68 4.3 0.1 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_9 PF13371.4 T093467_3 - 0.05 13.6 1.8 1 9.5 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 T093467_3 - 0.39 10.7 10.9 17 5.5 0.2 4.8 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat DUF4746 PF15928.3 T093467_3 - 0.5 9.6 7.5 0.95 8.7 7.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TPR_3 PF07720.10 T093467_3 - 1.2 9.1 11.7 1.1 9.2 0.1 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat Peptidase_S49_N PF08496.8 T093467_3 - 4.5 7.2 10.2 9.1 6.2 10.2 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal V-ATPase_H_N PF03224.12 T343957_2 - 4.7e-103 344.7 10.8 5.1e-103 344.5 8.3 2.0 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.6 T343957_2 - 3e-46 156.2 2.1 3.3e-46 156.1 0.3 2.0 2 0 0 2 2 2 1 V-ATPase subunit H Arm PF00514.21 T343957_2 - 5.3e-05 23.0 4.1 0.032 14.1 0.0 5.1 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Arm_2 PF04826.11 T343957_2 - 0.001 18.4 0.1 0.0029 17.0 0.0 1.7 2 0 0 2 2 2 1 Armadillo-like HEAT_2 PF13646.4 T343957_2 - 0.0015 18.7 0.1 1.8 8.9 0.0 3.7 3 1 0 3 3 3 1 HEAT repeats DUF2326 PF10088.7 T343957_2 - 0.0067 16.0 0.1 0.016 14.8 0.1 1.6 1 0 0 1 1 1 1 Uncharacterised protein conserved in bacteria (DUF2326) HEAT PF02985.20 T343957_2 - 0.05 13.7 0.1 1.2 9.4 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat UCH PF00443.27 T343957_2 - 0.3 10.4 1.2 0.59 9.5 0.9 1.4 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Arm PF00514.21 T038285_1 - 0.0019 18.0 0.0 0.011 15.6 0.0 2.2 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 T038285_1 - 0.0031 17.8 0.0 0.009 16.3 0.0 1.8 2 0 0 2 2 2 1 HEAT-like repeat HEAT_2 PF13646.4 T038285_1 - 0.1 12.9 0.0 0.41 10.9 0.0 1.8 1 1 1 2 2 2 0 HEAT repeats Arm PF00514.21 T038285_3 - 7.6e-13 47.9 3.9 1.2e-09 37.8 0.0 3.4 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 T038285_3 - 9.9e-05 22.5 2.4 0.0023 18.1 0.6 1.9 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.20 T038285_3 - 0.00016 21.5 0.9 0.71 10.1 0.1 3.5 3 0 0 3 3 3 2 HEAT repeat Cnd1 PF12717.5 T038285_3 - 0.013 15.4 0.0 0.95 9.3 0.0 2.1 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DNA_alkylation PF08713.9 T038285_3 - 0.062 12.9 0.1 1.9 8.0 0.0 2.1 1 1 1 2 2 2 0 DNA alkylation repair enzyme HEAT_EZ PF13513.4 T038285_3 - 0.25 11.7 2.9 23 5.4 2.6 2.5 1 1 0 1 1 1 0 HEAT-like repeat ANAPC4_WD40 PF12894.5 T047318_1 - 0.0025 17.9 0.3 0.77 10.0 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Sec16_C PF12931.5 T047318_1 - 0.023 14.2 0.1 0.035 13.6 0.1 1.2 1 0 0 1 1 1 0 Sec23-binding domain of Sec16 WD40 PF00400.30 T047318_1 - 0.033 14.9 4.0 1.6 9.6 0.0 4.7 4 1 1 5 5 5 0 WD domain, G-beta repeat NDUF_B8 PF05821.9 T047318_2 - 6.6e-75 250.7 6.6 9.3e-75 250.3 6.6 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Ion_trans PF00520.29 T071668_1 - 1.4e-248 820.1 84.3 2.5e-70 236.4 21.1 4.3 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 T071668_1 - 4.6e-37 128.4 12.3 7.1e-27 94.9 0.0 3.0 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 T071668_1 - 5.7e-36 122.0 0.0 1.2e-35 121.0 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 T071668_1 - 7.3e-27 93.3 0.0 1.9e-26 92.0 0.0 1.7 1 1 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 T071668_1 - 4.3e-07 28.8 26.8 3.6e-06 25.8 4.0 7.9 7 2 2 9 9 9 4 Polycystin cation channel RVT_1 PF00078.25 T291507_2 - 5e-06 26.0 0.1 1.2e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2_2 PF13465.4 T291507_3 - 1.2e-74 243.5 73.3 7.7e-08 32.3 0.1 13.7 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2 PF00096.24 T291507_3 - 3e-63 206.8 72.7 2.3e-06 27.6 0.9 13.2 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T291507_3 - 5.3e-26 88.9 77.6 0.0033 18.0 0.6 13.4 13 0 0 13 13 13 12 C2H2-type zinc finger KRAB PF01352.25 T291507_3 - 5.6e-26 89.8 0.6 1e-25 89.0 0.6 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 T291507_3 - 2.8e-05 24.0 57.7 0.081 12.9 2.8 7.9 2 2 3 8 8 8 6 Zinc ribbon domain zf-C2H2_6 PF13912.4 T291507_3 - 0.011 15.5 67.2 0.069 13.0 0.3 12.0 13 0 0 13 13 13 0 C2H2-type zinc finger C1_4 PF07975.10 T291507_3 - 0.05 13.7 48.9 2.9 8.1 5.2 8.1 2 2 6 9 9 9 0 TFIIH C1-like domain FMN_dh PF01070.16 T018435_1 - 3.5e-129 430.6 0.0 4.2e-129 430.4 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.23 T018435_1 - 3.2e-07 29.6 0.5 1.1e-05 24.5 0.2 2.1 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.15 T018435_1 - 3.3e-05 23.1 0.1 5e-05 22.5 0.1 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.19 T018435_1 - 0.067 12.5 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Histidine biosynthesis protein DHO_dh PF01180.19 T018435_1 - 0.11 11.6 0.2 0.26 10.3 0.2 1.4 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase DUF4322 PF14210.4 T028803_2 - 0.17 11.7 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4322) Tmemb_cc2 PF10267.7 T028803_3 - 2.4e-175 583.3 2.8 2.4e-175 583.3 2.8 1.8 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein Prominin PF05478.9 T028803_3 - 0.24 9.2 15.4 0.029 12.2 5.5 2.2 2 0 0 2 2 2 0 Prominin RAP1 PF07218.9 T028803_3 - 2.5 6.1 7.7 0.95 7.5 0.5 2.2 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) Baculo_PEP_C PF04513.10 T028803_3 - 3 7.8 10.3 0.39 10.6 2.2 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lipoprotein_20 PF13942.4 T028803_3 - 7.1 6.4 16.8 6.8 6.5 5.3 2.4 2 0 0 2 2 2 0 YfhG lipoprotein Exonuc_VII_L PF02601.13 T028803_3 - 8.4 5.7 24.2 0.74 9.2 0.7 2.7 3 0 0 3 3 3 0 Exonuclease VII, large subunit Trypsin PF00089.24 T130640_3 - 2.6e-74 249.6 0.0 1.3e-42 145.9 0.1 3.1 3 0 0 3 3 3 3 Trypsin VKOR PF07884.12 T130640_3 - 1.1e-24 86.9 12.8 1.8e-24 86.2 12.8 1.4 1 0 0 1 1 1 1 Vitamin K epoxide reductase family DUF1986 PF09342.9 T130640_3 - 3.8e-09 36.8 0.0 5e-05 23.5 0.0 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 T130640_3 - 2.8e-08 34.6 0.0 1.6e-05 25.6 0.0 2.7 2 0 0 2 2 2 2 Trypsin-like peptidase domain Proteasome PF00227.24 T016848_2 - 6.6e-54 182.1 0.1 8.9e-54 181.7 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit I-set PF07679.14 T016848_2 - 5.3e-21 74.3 0.0 7.3e-13 48.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Proteasome_A_N PF10584.7 T016848_2 - 1.7e-12 46.6 0.0 3.7e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Ig_3 PF13927.4 T016848_2 - 1.5e-11 44.6 0.0 1.1e-06 29.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain fn3 PF00041.19 T016848_2 - 4e-11 43.0 0.0 6.7e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain ig PF00047.23 T016848_2 - 0.00069 19.6 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T016848_2 - 0.0043 17.2 0.0 0.021 15.0 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Sortilin-Vps10 PF15902.3 T016848_3 - 5.2e-112 374.8 0.9 6.5e-112 374.4 0.9 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.3 T016848_3 - 5.9e-36 124.2 3.2 8.7e-36 123.7 3.2 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR_6 PF15899.3 T016848_3 - 3e-18 63.8 21.8 0.00043 20.0 0.2 6.5 6 0 0 6 6 6 5 BNR-Asp box repeat BNR PF02012.18 T016848_3 - 0.14 12.1 32.1 1.5 9.0 1.5 8.1 8 0 0 8 8 8 0 BNR/Asp-box repeat PI3_PI4_kinase PF00454.25 T020841_3 - 2.2e-33 116.0 0.2 4.6e-23 82.2 0.2 2.2 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.4 T020841_3 - 0.051 12.8 0.0 0.08 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) bZIP_1 PF00170.19 T357852_1 - 2.9e-11 43.1 10.8 6.3e-11 42.1 10.8 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 T357852_1 - 3.2e-08 33.4 9.6 3.2e-08 33.4 9.6 2.0 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.15 T357852_1 - 0.0008 19.7 7.4 0.0015 18.8 7.4 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor GIT_CC PF16559.3 T357852_1 - 0.41 10.6 4.4 0.98 9.4 4.4 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor JMY PF15871.3 T357852_1 - 4.7 6.3 9.7 3 6.9 8.1 1.3 1 1 0 1 1 1 0 Junction-mediating and -regulatory protein ACTH_domain PF00976.16 T228144_2 - 1.7 8.5 18.9 11 5.9 1.6 4.1 3 0 0 3 3 3 0 Corticotropin ACTH domain KH_1 PF00013.27 T228144_3 - 2e-53 177.9 13.9 2.7e-18 65.4 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 T228144_3 - 5.7e-13 48.4 7.0 0.00013 21.6 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 T228144_3 - 1.8e-06 27.6 1.1 0.029 14.1 0.3 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 T228144_3 - 0.0014 18.6 7.9 2 8.4 0.2 3.3 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.3 T228144_3 - 0.031 14.1 0.0 0.21 11.5 0.0 2.2 3 0 0 3 3 3 0 KH-like RNA-binding domain PDZ PF00595.22 T113457_3 - 2.1e-47 159.2 7.7 3.4e-16 59.2 0.2 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) ZU5 PF00791.18 T113457_3 - 4.2e-33 113.4 0.0 1.6e-32 111.6 0.0 1.9 2 0 0 2 2 2 1 ZU5 domain PDZ_2 PF13180.4 T113457_3 - 2.7e-17 62.7 4.7 3.2e-05 24.0 0.1 3.7 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.19 T113457_3 - 6.1e-13 48.7 0.0 1e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.15 T113457_3 - 5.9e-11 41.8 0.1 1.5e-10 40.5 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T113457_3 - 0.0024 17.3 0.1 0.022 14.2 0.0 2.7 2 0 0 2 2 2 1 SH3 domain RPOL_N PF14700.4 T113457_3 - 0.073 12.3 0.7 0.45 9.7 0.1 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal SLAIN PF15301.4 T096522_3 - 8.4e-157 522.7 28.1 2.6e-140 468.4 24.3 2.1 1 1 1 2 2 2 2 SLAIN motif-containing family IER PF05760.10 T169160_2 - 1.3e-17 65.0 0.3 1.9e-17 64.4 0.3 1.2 1 0 0 1 1 1 1 Immediate early response protein (IER) Piwi PF02171.15 T007921_1 - 7.9e-103 343.7 0.0 1.1e-102 343.2 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 T007921_1 - 4.1e-32 110.2 0.1 8.8e-32 109.1 0.1 1.6 1 0 0 1 1 1 1 Mid domain of argonaute PAZ PF02170.20 T007921_1 - 4.2e-28 97.8 2.0 7.2e-28 97.0 2.0 1.4 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.3 T007921_1 - 5.1e-27 95.0 0.0 9.5e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 T007921_1 - 3.5e-22 77.6 0.1 7.3e-22 76.6 0.1 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.3 T007921_1 - 1.7e-14 53.8 0.0 3.3e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Argonaute linker 2 domain p450 PF00067.20 T276002_2 - 1.8e-119 399.4 0.0 2.4e-119 399.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Trypsin PF00089.24 T276002_3 - 1.8e-74 250.2 1.7 2.8e-74 249.5 1.7 1.3 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.24 T276002_3 - 7.6e-33 112.2 31.1 1.3e-09 37.8 2.7 4.8 4 0 0 4 4 4 4 PAN domain PAN_4 PF14295.4 T276002_3 - 5.3e-12 45.3 13.9 8.4e-06 25.5 0.3 4.9 4 0 0 4 4 4 4 PAN domain Trypsin_2 PF13365.4 T276002_3 - 0.00019 22.2 0.0 0.00034 21.4 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 T276002_3 - 0.00028 21.1 0.1 0.00048 20.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) PAN_2 PF08276.9 T276002_3 - 3.1 7.8 18.7 0.014 15.3 1.4 4.0 4 0 0 4 4 4 0 PAN-like domain HDAC4_Gln PF12203.6 T319378_1 - 1.5e-31 108.2 43.7 1.5e-31 108.2 43.7 3.5 4 0 0 4 4 4 1 Glutamine rich N terminal domain of histone deacetylase 4 Maelstrom PF13017.4 T024437_3 - 7.8e-58 195.5 0.6 1.2e-57 195.0 0.6 1.2 1 0 0 1 1 1 1 piRNA pathway germ-plasm component HMG_box_2 PF09011.8 T024437_3 - 4.9e-26 91.0 0.4 8.3e-26 90.3 0.4 1.4 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.17 T024437_3 - 5.4e-05 23.4 0.4 0.00011 22.4 0.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box UPAR_LY6 PF00021.19 T353128_1 - 1.2e-12 48.2 11.4 1.2e-12 48.2 11.4 2.0 2 0 0 2 2 2 1 u-PAR/Ly-6 domain Toxin_1 PF00087.19 T353128_1 - 1.1e-06 28.7 9.9 1.1e-06 28.7 9.9 2.5 2 0 0 2 2 2 1 Snake toxin EpoR_lig-bind PF09067.8 T280886_2 - 8.6e-22 77.2 0.0 1.7e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 T280886_2 - 1.5e-06 28.3 0.1 0.0093 16.2 0.0 2.5 2 0 0 2 2 2 2 Fibronectin type III domain IL6Ra-bind PF09240.8 T280886_2 - 1.3e-05 25.4 0.1 1.3e-05 25.4 0.1 2.2 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding Aminotran_3 PF00202.19 T280886_3 - 2.1e-88 296.6 0.0 3.1e-88 296.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III PIP5K PF01504.16 T206619_1 - 1.9e-43 148.6 0.9 6e-34 117.4 0.6 2.4 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.22 T206619_1 - 6.2e-35 120.6 0.8 9.3e-35 120.0 0.8 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DEP PF00610.19 T206619_1 - 1.1e-18 66.8 0.0 2.4e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) tRNA-synt_1 PF00133.20 T301206_1 - 3.6e-200 666.1 0.0 3.8e-199 662.7 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.11 T301206_1 - 2.3e-32 111.9 0.0 3.9e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA GST_C PF00043.23 T301206_1 - 2.3e-12 46.8 0.0 7.6e-12 45.2 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1g PF09334.9 T301206_1 - 9.4e-11 41.0 0.0 5.8e-05 21.9 0.0 3.8 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.4 T301206_1 - 4.5e-10 39.2 3.6 7e-10 38.6 0.0 2.5 2 1 1 3 3 3 1 Leucyl-tRNA synthetase, Domain 2 GST_C_2 PF13410.4 T301206_1 - 0.034 14.0 0.2 0.14 12.0 0.2 2.1 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Jag_N PF14804.4 T301206_1 - 0.11 12.8 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Jag N-terminus tRNA-synt_1e PF01406.17 T301206_1 - 0.16 11.1 0.0 0.82 8.8 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain SUIM_assoc PF16619.3 T301206_1 - 6.2 6.9 6.9 19 5.3 6.9 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Het-C PF07217.9 T301206_3 - 0.004 15.6 0.0 0.0056 15.1 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Peptidase_C2 PF00648.19 T187282_2 - 1.7e-28 99.4 0.0 2.2e-28 99.0 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C2 PF00648.19 T187282_3 - 4.5e-48 163.7 0.1 6.5e-48 163.1 0.1 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 T187282_3 - 3.1e-41 140.8 0.0 5.2e-41 140.1 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 T187282_3 - 0.00033 19.9 0.0 0.032 13.6 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 T187282_3 - 0.0031 17.2 0.0 2.2 8.3 0.0 2.8 1 1 1 2 2 2 2 EF-hand domain MLIP PF15274.4 T305397_2 - 6.8e-68 229.2 2.5 1.5e-36 126.5 0.4 2.2 1 1 1 2 2 2 2 Muscular LMNA-interacting protein EF-hand_4 PF12763.5 T146264_1 - 0.055 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DEAD PF00270.27 T146264_2 - 2.6e-36 124.9 0.0 3.8e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T146264_2 - 4.2e-29 101.0 0.1 1.2e-28 99.5 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 T146264_2 - 0.0003 20.7 0.0 0.00066 19.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 T146264_2 - 0.013 15.7 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain CK1gamma_C PF12605.6 T146264_2 - 0.18 12.9 0.6 0.44 11.6 0.6 1.6 1 0 0 1 1 1 0 Casein kinase 1 gamma C terminal Peptidase_M24 PF00557.22 T234202_1 - 8e-55 185.6 0.0 1.1e-54 185.2 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.14 T234202_1 - 3.6e-36 123.5 0.0 5.7e-36 122.8 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain MGC-24 PF05283.9 T006365_2 - 8.3e-35 120.1 12.9 9.7e-33 113.4 12.9 2.2 1 1 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin zf-TRAF PF02176.16 T029889_1 - 1.2e-31 109.1 26.5 1.3e-18 67.3 6.1 3.6 1 1 2 3 3 3 2 TRAF-type zinc finger zf-C3HC4 PF00097.23 T029889_1 - 1.3e-05 24.8 8.6 0.00013 21.6 8.6 3.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T029889_1 - 0.00013 21.6 9.4 0.00013 21.6 9.4 3.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T029889_1 - 0.00079 19.4 6.8 0.00079 19.4 6.8 3.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-TRAF_2 PF15965.3 T029889_1 - 0.0014 18.9 9.0 0.0014 18.9 9.0 3.1 3 0 0 3 3 3 1 TRAF-like zinc-finger zf-RING_2 PF13639.4 T029889_1 - 0.0019 18.3 8.9 0.036 14.2 8.9 3.5 1 0 0 1 1 1 1 Ring finger domain Sina PF03145.14 T029889_1 - 2.6 7.9 22.4 0.2 11.4 3.1 2.7 2 1 0 3 3 3 0 Seven in absentia protein family Mt_ATP_synt PF15704.3 T029889_3 - 0.085 12.6 2.0 0.14 11.9 2.0 1.2 1 0 0 1 1 1 0 Mitochondrial ATP synthase subunit BLOC1_2 PF10046.7 T029889_3 - 2.1 8.5 6.0 2.3 8.5 2.9 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 T-box PF00907.20 T315173_3 - 3.5e-72 242.4 0.0 5.9e-72 241.6 0.0 1.4 1 0 0 1 1 1 1 T-box Motile_Sperm PF00635.24 T220977_3 - 4.6e-31 106.8 0.1 7.6e-31 106.1 0.1 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ZapB PF06005.10 T220977_3 - 0.12 12.7 1.3 0.21 11.9 1.3 1.3 1 0 0 1 1 1 0 Cell division protein ZapB WD40 PF00400.30 T329783_2 - 6.5e-39 131.1 20.7 5.8e-06 26.8 0.0 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T329783_2 - 1.7e-14 53.7 0.0 0.0013 18.8 0.0 5.3 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 T329783_2 - 0.00016 21.0 0.0 0.00039 19.7 0.0 1.5 1 1 0 1 1 1 1 WD40-like domain CALM_bind PF16025.3 T329783_2 - 0.65 10.3 2.6 0.33 11.3 0.1 1.7 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding FXMRP1_C_core PF12235.6 T329783_2 - 7.7 7.0 12.6 5.5 7.5 0.5 2.8 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal GDPD PF03009.15 T128255_3 - 3.7e-32 111.9 0.0 5.2e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Y_phosphatase PF00102.25 T208120_3 - 4.6e-74 248.8 0.0 6e-74 248.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RESP18 PF14948.4 T208120_3 - 9.3e-34 115.8 0.8 9.3e-34 115.8 0.8 2.2 2 0 0 2 2 2 1 RESP18 domain Receptor_IA-2 PF11548.6 T208120_3 - 6.5e-16 57.9 0.4 2.3e-15 56.2 0.2 1.9 1 1 1 2 2 2 1 Protein-tyrosine phosphatase receptor IA-2 DSPc PF00782.18 T208120_3 - 0.058 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain FA_hydroxylase PF04116.11 T045871_3 - 4.7e-21 75.4 24.5 4.7e-21 75.4 24.5 2.6 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily Cadherin PF00028.15 T043612_1 - 1.9e-58 194.8 1.5 2.8e-20 72.4 0.0 5.1 5 0 0 5 5 5 4 Cadherin domain Cadherin_2 PF08266.10 T043612_1 - 2.8e-05 23.7 0.0 0.33 10.7 0.0 3.0 3 1 0 3 3 3 2 Cadherin-like Insulin PF00049.16 T170500_2 - 0.11 13.3 0.0 0.23 12.4 0.0 1.4 1 0 0 1 1 1 0 Insulin/IGF/Relaxin family Pkinase_Tyr PF07714.15 T170500_3 - 1.1e-133 444.3 0.0 2.2e-79 266.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.23 T170500_3 - 2.7e-65 220.2 0.0 1.3e-45 155.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Kdo PF06293.12 T170500_3 - 0.011 15.0 0.0 0.2 10.8 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family SH2 PF00017.22 T170500_3 - 0.022 14.7 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 SH2 domain APH PF01636.21 T170500_3 - 0.023 14.5 0.9 0.052 13.3 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family OATP PF03137.18 T075038_2 - 2.5e-169 564.0 24.2 3e-169 563.7 24.2 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 T075038_2 - 5.9e-24 84.5 8.9 5.9e-24 84.5 8.9 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.13 T075038_2 - 1.5e-09 37.8 1.9 3.8e-09 36.5 1.9 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 T075038_2 - 0.0022 17.8 5.3 0.003 17.4 2.8 2.6 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain DUF4616 PF15394.4 T101166_2 - 4.5e-195 649.5 1.2 3.2e-172 574.0 0.1 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4616) Myb_DNA-binding PF00249.29 T088659_2 - 5e-19 68.1 0.5 1.6e-11 44.0 0.2 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T088659_2 - 0.00015 21.8 5.8 0.011 15.9 0.5 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 T088659_2 - 0.024 14.4 19.8 0.55 10.0 3.3 2.6 2 0 0 2 2 2 0 Myb DNA-binding like DUF4518 PF15008.4 T088659_2 - 0.21 10.6 7.7 0.4 9.7 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) Serinc PF03348.13 T088659_2 - 0.46 9.2 3.5 0.84 8.4 3.5 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Spt20 PF12090.6 T088659_2 - 4.7 6.6 26.7 0.013 15.0 16.2 2.1 2 0 0 2 2 2 0 Spt20 family CLN3 PF02487.15 T088659_2 - 7.3 5.4 5.2 15 4.4 5.2 1.5 1 0 0 1 1 1 0 CLN3 protein TAF1D PF15333.4 T088659_3 - 0.74 9.4 7.7 1.5 8.3 7.7 1.4 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D Far-17a_AIG1 PF04750.12 T297487_3 - 6.1e-62 208.4 14.2 9.3e-62 207.8 14.2 1.3 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein WD40 PF00400.30 T207026_1 - 1.7e-17 63.3 16.5 6.2e-07 29.9 0.1 6.0 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T207026_1 - 2.5e-05 24.3 0.0 0.22 11.7 0.0 3.6 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ARL2_Bind_BART PF11527.6 T133133_1 - 2.1e-31 108.3 7.8 3.3e-31 107.7 7.8 1.3 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART SPRY PF00622.26 T133133_3 - 1.9e-18 66.6 0.5 3e-18 66.0 0.5 1.3 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.4 T133133_3 - 1.5e-07 31.0 14.0 7.2e-07 28.8 14.0 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 T133133_3 - 0.0008 19.1 11.0 0.0008 19.1 11.0 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Pex24p PF06398.9 T205866_3 - 0.23 10.3 0.0 0.25 10.1 0.0 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Glycos_transf_1 PF00534.18 T363731_3 - 8.5e-35 119.7 0.0 1.3e-34 119.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.4 T363731_3 - 1.9e-16 60.5 0.0 3.2e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.4 T363731_3 - 1.3e-15 57.7 0.0 1.3e-15 57.7 0.0 2.7 4 0 0 4 4 4 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.4 T363731_3 - 6e-14 52.7 1.1 5.5e-13 49.5 0.2 2.6 3 0 0 3 3 3 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.4 T363731_3 - 1.7e-05 25.0 0.0 3.2e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF1736 PF08409.9 T098235_1 - 4.2e-33 113.0 3.7 7e-33 112.3 3.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_1 PF00515.26 T098235_2 - 5e-34 114.6 19.4 1.5e-05 24.5 0.1 7.4 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_2 PF07719.15 T098235_2 - 1e-28 97.0 17.2 1.6e-05 24.5 0.3 7.5 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.4 T098235_2 - 1.7e-26 90.1 9.8 5.5e-05 22.9 0.1 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.4 T098235_2 - 9.2e-26 90.1 6.1 1.1e-07 32.3 0.1 4.7 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.4 T098235_2 - 1.2e-24 84.7 20.2 9.6e-06 25.5 0.3 7.6 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_11 PF13414.4 T098235_2 - 1.9e-23 81.7 16.2 8.4e-06 25.2 0.2 7.2 2 2 6 8 8 8 6 TPR repeat TPR_12 PF13424.4 T098235_2 - 3.2e-17 62.5 16.6 2.9e-05 24.2 0.4 5.6 2 2 4 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.4 T098235_2 - 1.8e-15 56.2 8.0 0.0095 16.6 0.1 8.3 1 1 7 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.4 T098235_2 - 5.2e-13 49.2 10.7 1.7e-06 28.3 0.9 4.3 1 1 5 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.4 T098235_2 - 1.1e-11 44.1 24.1 0.00012 21.7 0.5 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.4 T098235_2 - 9.5e-08 31.4 5.3 4.8 7.3 0.1 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.4 T098235_2 - 0.00074 18.7 6.9 0.0058 15.7 1.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 T098235_2 - 0.0023 17.9 5.7 0.036 14.1 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.12 T098235_2 - 0.016 15.6 7.0 2.9 8.7 0.0 5.5 6 0 0 6 6 5 0 Tetratricopeptide repeat NARP1 PF12569.6 T098235_2 - 0.018 13.8 0.7 0.3 9.8 0.1 2.2 2 1 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_6 PF13174.4 T098235_2 - 0.026 15.0 5.4 5.9 7.6 0.1 4.6 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_20 PF14561.4 T098235_2 - 0.027 14.7 1.5 2.4 8.4 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat FAT PF02259.21 T098235_2 - 0.14 11.2 2.0 0.14 11.2 0.3 1.8 2 1 0 2 2 2 0 FAT domain BTAD PF03704.15 T098235_2 - 0.23 11.8 1.2 0.93 9.8 0.0 2.1 2 0 0 2 2 2 0 Bacterial transcriptional activator domain ANAPC3 PF12895.5 T098235_2 - 0.51 10.4 6.8 7.4 6.7 0.9 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Hemopexin PF00045.17 T053975_1 - 8.5e-43 143.9 14.6 3.2e-11 42.8 0.1 6.2 6 0 0 6 6 6 5 Hemopexin zf-RING_UBOX PF13445.4 T053975_1 - 9e-08 31.9 11.5 5.4e-07 29.4 11.5 2.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 T053975_1 - 1.5e-06 27.8 12.7 5.7e-06 26.0 12.7 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T053975_1 - 4.2e-06 26.8 12.2 2.4e-05 24.3 12.2 2.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 T053975_1 - 4.8e-06 26.2 12.7 1.7e-05 24.4 12.7 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T053975_1 - 8.7e-06 25.5 11.3 3.8e-05 23.4 11.3 2.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 T053975_1 - 3.5e-05 23.5 10.6 3.5e-05 23.5 10.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T053975_1 - 0.0072 16.3 14.8 0.024 14.7 14.8 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.5 T053975_1 - 0.0077 16.1 3.8 0.023 14.6 3.8 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 T053975_1 - 1.6 8.4 8.1 5.3 6.7 8.1 2.0 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.4 T053975_1 - 3.2 7.6 22.2 0.006 16.3 11.1 2.3 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 NHL PF01436.19 T053975_2 - 1.2e-46 154.3 22.9 4.9e-09 35.6 0.2 7.4 7 0 0 7 7 7 6 NHL repeat Filamin PF00630.17 T053975_2 - 1.1e-17 64.5 0.0 2.2e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat DUF5128 PF17170.2 T053975_2 - 5.1e-14 52.0 1.3 2.4e-06 26.8 0.1 3.2 1 1 3 4 4 4 4 6-bladed beta-propeller SGL PF08450.10 T053975_2 - 1.3e-11 44.4 2.7 0.00024 20.6 0.0 4.2 1 1 3 4 4 4 3 SMP-30/Gluconolaconase/LRE-like region zf-B_box PF00643.22 T053975_2 - 2.9e-07 30.4 0.7 9.3e-07 28.8 0.7 1.9 1 0 0 1 1 1 1 B-box zinc finger DUF4934 PF16288.3 T053975_2 - 0.00096 18.9 0.9 0.67 9.8 0.2 2.8 2 1 1 3 3 3 3 Domain of unknown function (DUF4934) SBBP PF06739.9 T053975_2 - 0.0054 16.6 2.0 3 7.8 0.4 3.3 3 0 0 3 3 3 1 Beta-propeller repeat Apolipoprotein PF01442.16 T053975_2 - 0.75 9.5 6.8 1.3 8.8 6.8 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain zf-met PF12874.5 T079712_3 - 8.6e-23 79.9 15.0 1.7e-08 34.4 1.8 3.3 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T079712_3 - 1.9e-15 56.6 13.0 5.4e-05 23.3 1.8 3.4 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 T079712_3 - 7.4e-07 29.3 4.0 0.48 10.7 0.2 3.1 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.10 T079712_3 - 0.00044 19.8 4.8 0.16 11.6 0.0 3.3 3 0 0 3 3 3 1 U1 zinc finger AKAP95 PF04988.10 T079712_3 - 0.00065 19.8 2.8 0.63 10.1 0.1 3.0 3 0 0 3 3 3 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2 PF00096.24 T079712_3 - 0.0011 19.1 9.0 0.51 10.8 0.2 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-DBF PF07535.10 T079712_3 - 0.0037 17.2 6.1 0.034 14.1 0.2 3.2 3 0 0 3 3 3 1 DBF zinc finger zf-C2H2_4 PF13894.4 T079712_3 - 0.0047 17.5 3.8 1.3 9.9 0.3 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_9 PF16293.3 T079712_3 - 0.089 12.5 3.6 8.2 6.2 0.1 3.1 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) DUF3449 PF11931.6 T079712_3 - 0.18 11.4 1.0 9.1 5.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Actin_micro PF17003.3 T079712_3 - 1.5 7.8 3.1 17 4.3 0.0 2.7 3 0 0 3 3 3 0 Putative actin-like family CAGE1 PF15066.4 T124441_1 - 0.023 13.3 0.1 0.033 12.7 0.1 1.2 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family DUF4472 PF14739.4 T124441_3 - 5.2e-25 88.1 2.0 1e-24 87.2 2.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4472) Linker_histone PF00538.17 T005005_2 - 1e-49 166.6 0.3 1.1e-17 64.0 0.1 3.3 3 0 0 3 3 3 3 linker histone H1 and H5 family MAM PF00629.21 T360073_3 - 1.8e-123 408.1 4.8 6.6e-34 117.0 1.0 4.7 4 1 0 4 4 4 4 MAM domain, meprin/A5/mu Sema PF01403.17 T242081_1 - 1.4e-54 185.3 0.0 2e-54 184.9 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 T242081_1 - 1.3e-36 124.4 0.0 7.8e-11 41.8 0.0 5.2 4 1 0 4 4 4 4 IPT/TIG domain PSI PF01437.23 T242081_1 - 1.8e-18 66.7 48.8 7e-11 42.4 13.3 4.4 3 0 0 3 3 3 3 Plexin repeat Plexin_cytopl PF08337.10 T242081_3 - 9.8e-228 757.2 0.0 1.2e-227 756.8 0.0 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain KRTDAP PF15200.4 T173716_1 - 4.5e-41 138.4 12.3 2.4e-37 126.4 0.2 3.3 2 1 1 3 3 3 3 Keratinocyte differentiation-associated Homeobox PF00046.27 T024945_2 - 9.8e-22 76.4 6.1 9.8e-22 76.4 6.1 1.7 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 T024945_2 - 0.013 15.3 0.2 0.025 14.3 0.2 1.5 1 0 0 1 1 1 0 Homeobox KN domain UNC-79 PF14776.4 T315323_1 - 0.12 10.9 0.0 0.17 10.4 0.0 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 Tcp10_C PF07202.11 T315323_2 - 6.2e-09 35.9 0.0 8.3e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 T-complex protein 10 C-terminus KAR9 PF08580.8 T315323_3 - 6.5 5.0 9.7 8.1 4.7 9.7 1.2 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Glyco_transf_29 PF00777.16 T196249_2 - 5e-37 127.6 0.0 8.1e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) DUF1725 PF08333.9 T211163_1 - 4.5e-06 26.0 1.0 4.5e-06 26.0 1.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) Ank_2 PF12796.5 T211163_3 - 1.6e-21 76.5 0.1 1.2e-08 35.3 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 T211163_3 - 7.6e-17 60.8 15.5 3e-05 24.1 0.1 7.3 8 0 0 8 8 8 5 Ankyrin repeat Ank_4 PF13637.4 T211163_3 - 6.4e-14 52.0 4.7 0.0023 18.3 0.0 5.9 4 1 2 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 T211163_3 - 1e-12 46.9 4.9 0.011 16.1 0.1 7.3 7 0 0 7 7 7 2 Ankyrin repeat MORN PF02493.18 T211163_3 - 1.2e-05 24.8 17.0 0.00019 21.0 2.2 3.9 4 0 0 4 4 4 2 MORN repeat zf-MYND PF01753.16 T211163_3 - 3e-05 23.9 8.5 3e-05 23.9 8.5 2.8 2 0 0 2 2 2 1 MYND finger Ank_5 PF13857.4 T211163_3 - 0.0082 16.4 6.5 19 5.6 0.1 5.2 4 2 1 5 5 5 1 Ankyrin repeats (many copies) BCOR PF15808.3 T373363_1 - 2.7e-74 249.9 17.7 1e-73 248.1 17.7 2.1 1 0 0 1 1 1 1 BCL-6 co-repressor, non-ankyrin-repeat region PUFD PF16553.3 T373363_1 - 4.2e-52 175.0 0.8 7.5e-52 174.2 0.8 1.4 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain Ank_2 PF12796.5 T373363_1 - 6.9e-16 58.5 0.6 3.1e-15 56.4 0.4 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T373363_1 - 3.8e-14 51.3 1.6 0.00011 22.2 0.2 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.4 T373363_1 - 1.3e-11 44.3 6.4 3.4e-09 36.7 0.1 3.8 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 T373363_1 - 1.1e-10 41.6 1.6 1.9e-06 28.2 0.4 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 T373363_1 - 2e-09 37.3 1.4 0.0021 18.3 0.1 3.7 2 1 1 3 3 3 2 Ankyrin repeat JCAD PF15351.4 T039220_3 - 0 2300.9 65.1 0 2300.7 65.1 1.0 1 0 0 1 1 1 1 Junctional protein associated with coronary artery disease Defensin_2 PF01097.16 T253307_3 - 0.032 14.0 0.3 0.057 13.2 0.3 1.4 1 0 0 1 1 1 0 Arthropod defensin AAA_12 PF13087.4 T269743_3 - 2.7e-50 170.6 0.6 7.3e-50 169.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.4 T269743_3 - 4.3e-22 79.0 0.1 6.4e-18 65.3 0.3 4.0 4 1 1 5 5 5 2 AAA domain DUF2439 PF10382.7 T269743_3 - 7.8e-19 67.7 0.1 7.8e-19 67.7 0.1 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF2439) zf-GRF PF06839.10 T269743_3 - 2.3e-13 49.8 0.3 5.9e-13 48.6 0.3 1.8 1 0 0 1 1 1 1 GRF zinc finger Viral_helicase1 PF01443.16 T269743_3 - 2.4e-06 27.3 0.1 0.13 11.9 0.0 3.7 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.4 T269743_3 - 0.0032 17.1 0.0 0.27 10.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.4 T269743_3 - 0.038 14.2 0.0 0.093 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain Pkinase_Tyr PF07714.15 T156291_3 - 4.2e-56 190.0 0.0 5.7e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T156291_3 - 4.6e-32 111.3 0.0 6.8e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Lectin_C PF00059.19 T357791_1 - 3.8e-13 50.0 7.7 6.3e-13 49.3 7.7 1.4 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 T357791_1 - 0.0023 17.5 1.2 0.0023 17.5 1.2 1.7 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like DMPK_coil PF08826.8 T357791_1 - 0.0099 15.8 12.4 0.0099 15.8 12.4 2.1 2 0 0 2 2 2 1 DMPK coiled coil domain like Exonuc_VII_L PF02601.13 T357791_1 - 2.7 7.4 10.1 3.9 6.8 10.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.10 T357791_1 - 2.8 7.8 8.2 6.3 6.7 8.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.11 T357791_1 - 3.8 8.1 8.0 31 5.2 4.4 2.3 2 0 0 2 2 2 0 Occludin homology domain IncA PF04156.12 T357791_1 - 4.7 6.8 22.9 14 5.2 23.0 1.7 1 1 0 1 1 1 0 IncA protein HOOK PF05622.10 T357791_1 - 5.6 4.8 18.1 7.7 4.4 18.1 1.1 1 0 0 1 1 1 0 HOOK protein DUF3450 PF11932.6 T357791_1 - 5.9 6.0 14.7 9.8 5.3 14.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Tmemb_cc2 PF10267.7 T250426_3 - 4.3e-165 549.5 13.7 6.3e-165 549.0 13.7 1.2 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein ATF7IP_BD PF16788.3 T250426_3 - 5.8 6.9 12.0 0.026 14.6 2.0 1.9 2 0 0 2 2 2 0 ATF-interacting protein binding domain FSA_C PF10479.7 T270679_2 - 4.4e-160 534.0 16.1 1.2e-127 426.9 3.1 2.8 2 1 1 3 3 3 2 Fragile site-associated protein C-terminus TTL PF03133.13 T216069_1 - 8.4e-37 126.7 0.3 1.3e-36 126.1 0.3 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family TTL PF03133.13 T216069_3 - 1.3e-33 116.2 0.0 1.9e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 T216069_3 - 1.1e-05 24.7 0.0 1.7e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 T216069_3 - 0.01 14.9 0.0 0.015 14.4 0.0 1.1 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp PP2C PF00481.19 T151527_1 - 1.6e-05 24.5 0.0 2.3e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SNCAIP_SNCA_bd PF16700.3 T288047_1 - 3.8e-24 84.0 7.3 8.2e-24 82.9 7.3 1.6 1 0 0 1 1 1 1 Synphilin-1 alpha-Synuclein-binding domain Ank_2 PF12796.5 T288047_1 - 2.5e-16 59.9 1.1 4.9e-07 30.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T288047_1 - 4.4e-13 49.1 0.5 0.0021 18.3 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 T288047_1 - 8.9e-13 48.3 0.5 0.00038 20.8 0.0 4.3 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 T288047_1 - 1e-06 28.8 2.0 0.012 15.9 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 T288047_1 - 0.00017 21.6 0.4 1.3 9.6 0.1 4.0 4 0 0 4 4 4 2 Ankyrin repeat Lzipper-MIP1 PF14389.4 T288047_1 - 0.84 9.8 4.6 0.92 9.7 1.7 2.4 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Lectin_C PF00059.19 T073701_2 - 2.3e-08 34.6 0.0 3.3e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain AA_permease PF00324.19 T114104_1 - 7.4e-52 176.4 25.6 9.7e-40 136.4 7.0 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 T114104_1 - 5.1e-49 167.3 7.0 6.1e-29 101.1 4.1 3.2 1 1 1 2 2 2 2 Solute carrier family 12 EPTP PF03736.15 T227756_2 - 7.9e-59 195.3 19.2 4.6e-13 48.8 0.5 6.3 6 0 0 6 6 6 6 EPTP domain EPTP PF03736.15 T227756_3 - 1.2e-13 50.7 0.2 4.8e-08 32.7 0.1 2.4 2 0 0 2 2 2 2 EPTP domain RRM_1 PF00076.20 T090893_1 - 1.2e-31 108.2 0.1 3.1e-15 55.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.9 T090893_1 - 1.4e-28 98.6 2.4 2.8e-28 97.7 2.4 1.5 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.3 T090893_1 - 0.0021 18.0 0.0 0.0087 16.0 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif Aldedh PF00171.20 T090893_1 - 8.7 4.6 5.4 13 4.0 5.4 1.1 1 0 0 1 1 1 0 Aldehyde dehydrogenase family IL8 PF00048.18 T145940_2 - 5.2e-21 74.4 0.7 1.3e-20 73.2 0.7 1.7 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like HEAT_2 PF13646.4 T145940_3 - 1.3e-11 44.6 1.5 0.00023 21.3 0.2 3.5 3 1 1 4 4 4 2 HEAT repeats DUF3385 PF11865.6 T145940_3 - 0.035 13.8 1.0 1.9 8.2 0.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF3385) PDZ PF00595.22 T092078_1 - 5.6e-62 206.0 0.2 7.6e-15 54.9 0.0 4.2 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T092078_1 - 1.9e-18 66.4 0.1 8.5e-06 25.9 0.0 4.3 4 0 0 4 4 4 4 PDZ domain zf-C3HC4_2 PF13923.4 T092078_1 - 6.6e-08 32.1 8.4 6.6e-08 32.1 8.4 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T092078_1 - 1e-07 31.5 6.7 1e-07 31.5 6.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T092078_1 - 5.4e-07 29.4 8.3 1.8e-06 27.7 8.3 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 T092078_1 - 1.5e-06 28.2 6.1 1.5e-06 28.2 6.1 3.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 T092078_1 - 5.7e-06 26.1 5.4 2e-05 24.3 5.4 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 T092078_1 - 8.7e-06 25.4 3.5 8.7e-06 25.4 3.5 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T092078_1 - 0.00022 21.2 7.6 0.00022 21.2 7.6 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.5 T092078_1 - 0.19 11.9 11.5 0.015 15.5 5.6 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.4 T092078_1 - 1.7 8.5 10.3 0.2 11.4 5.4 2.1 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 DZR PF12773.5 T092078_1 - 2 8.4 9.0 1.6 8.7 4.7 2.7 2 1 0 2 2 2 0 Double zinc ribbon IP_trans PF02121.16 T088323_1 - 2.8e-112 374.2 1.4 5.3e-112 373.2 1.4 1.5 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein DDHD PF02862.15 T088323_1 - 9.4e-31 107.6 0.1 9.4e-31 107.6 0.1 4.5 4 2 0 4 4 4 1 DDHD domain Laminin_II PF06009.10 T088323_1 - 2.5 8.0 10.2 6.6 6.6 2.1 2.8 2 0 0 2 2 2 0 Laminin Domain II Reo_sigmaC PF04582.10 T088323_1 - 2.7 7.1 6.6 4 6.6 0.9 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DDHD PF02862.15 T088323_3 - 9.1e-16 58.6 0.0 1.5e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 DDHD domain Sugar_tr PF00083.22 T240344_3 - 5.4e-18 64.9 17.3 8.4e-17 61.0 17.3 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 T240344_3 - 6.3e-14 51.5 38.7 2.7e-13 49.4 25.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM238 PF15125.4 T240344_3 - 0.018 15.1 2.5 0.018 15.1 2.5 2.0 2 0 0 2 2 2 0 TMEM238 protein family Sod_Cu PF00080.18 T061733_1 - 1.3e-24 86.8 0.0 1.5e-14 54.2 0.0 2.2 2 0 0 2 2 2 2 Copper/zinc superoxide dismutase (SODC) RRM_1 PF00076.20 T061733_2 - 3.9e-60 199.5 0.4 4.1e-15 55.2 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 T061733_2 - 2.8e-14 52.7 0.4 0.0033 16.9 0.1 4.4 2 2 2 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 T061733_2 - 2.4e-06 27.2 3.2 6e-06 26.0 3.2 1.7 1 0 0 1 1 1 1 Zinc knuckle RRM_occluded PF16842.3 T061733_2 - 2.6e-05 23.9 0.4 0.41 10.4 0.0 3.6 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_7 PF16367.3 T061733_2 - 0.00011 22.1 0.0 0.26 11.3 0.0 4.0 4 0 0 4 4 4 1 RNA recognition motif DbpA PF03880.13 T061733_2 - 0.00069 19.4 1.8 0.18 11.7 0.1 3.3 3 0 0 3 3 3 1 DbpA RNA binding domain zf-CCHC_3 PF13917.4 T061733_2 - 0.045 13.6 0.3 0.11 12.4 0.3 1.6 1 0 0 1 1 1 0 Zinc knuckle HMA PF00403.24 T061733_3 - 4.7e-08 33.2 0.1 7.3e-08 32.6 0.1 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain Fringe PF02434.14 T156796_1 - 1.4e-20 73.6 0.0 2.1e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Fringe-like Fringe PF02434.14 T156796_3 - 1.1e-81 273.8 0.0 3.5e-48 164.1 0.0 2.1 2 0 0 2 2 2 2 Fringe-like Pep_M12B_propep PF01562.17 T167596_1 - 6.7e-31 107.3 0.0 1.2e-30 106.5 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide hSH3 PF14603.4 T167596_1 - 5.5e-30 103.6 0.0 9.3e-30 102.9 0.0 1.3 1 0 0 1 1 1 1 Helically-extended SH3 domain Reprolysin PF01421.17 T167596_1 - 9.2e-23 81.1 0.0 1.4e-22 80.5 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 T167596_1 - 1.3e-12 48.1 0.2 2.4e-12 47.3 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T167596_1 - 1.8e-10 41.2 0.1 2.8e-10 40.6 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T167596_1 - 5.2e-09 36.1 0.2 8.2e-09 35.5 0.2 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T167596_1 - 3.8e-06 26.6 0.1 6.4e-06 25.8 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like SH3_2 PF07653.15 T167596_1 - 0.0059 16.1 0.0 0.015 14.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain ADAM_spacer1 PF05986.12 T167596_2 - 9e-24 83.6 0.0 1.3e-23 83.1 0.0 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.17 T167596_2 - 1.3e-13 50.8 72.5 1.8e-06 27.9 9.7 7.0 6 0 0 6 6 6 5 Thrombospondin type 1 domain PLAC PF08686.9 T167596_2 - 2.4e-08 34.4 11.0 8.3e-08 32.7 11.0 2.1 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Myosin_head PF00063.19 T167596_3 - 8.2e-248 823.9 0.0 9.8e-248 823.7 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) zf-C2H2_8 PF15909.3 T167596_3 - 7.3e-57 189.6 12.1 1.6e-56 188.5 12.1 1.6 1 0 0 1 1 1 1 C2H2-type zinc ribbon Myosin_TH1 PF06017.11 T167596_3 - 1.6e-51 174.5 0.0 2.4e-51 173.9 0.0 1.3 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_9 PF14604.4 T167596_3 - 1.2e-13 50.5 0.2 2.6e-13 49.5 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T167596_3 - 2.8e-13 49.1 0.3 6.8e-13 47.9 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 T167596_3 - 4.8e-11 42.1 0.1 1.3e-10 40.7 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain zf-H2C2_5 PF13909.4 T167596_3 - 0.034 13.8 1.8 0.049 13.3 0.1 2.2 2 0 0 2 2 2 0 C2H2-type zinc-finger domain IQ PF00612.25 T167596_3 - 6.7 6.7 5.9 1.4 8.7 1.2 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif zf-C2H2_6 PF13912.4 T167596_3 - 9.1 6.2 11.7 2.2 8.2 0.2 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger HCO3_cotransp PF00955.19 T191991_2 - 1.7e-222 739.7 6.7 2.5e-222 739.2 6.7 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 T191991_2 - 8.5e-104 347.0 0.0 8.5e-104 347.0 0.0 3.8 3 1 0 3 3 3 1 Band 3 cytoplasmic domain Dynactin PF12455.6 T191991_2 - 2.3e-101 338.7 4.9 2.3e-101 338.7 4.9 3.5 4 0 0 4 4 4 1 Dynein associated protein CAP_GLY PF01302.23 T191991_2 - 3.3e-22 78.1 2.4 7.4e-22 77.0 2.4 1.6 1 0 0 1 1 1 1 CAP-Gly domain Vps39_1 PF10366.7 T191991_2 - 0.11 12.7 0.8 0.54 10.4 0.8 2.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 Xan_ur_permease PF00860.18 T191991_2 - 0.16 10.5 8.6 0.074 11.6 0.6 2.3 2 0 0 2 2 2 0 Permease family Fe_hyd_lg_C PF02906.12 T191991_2 - 1 8.8 4.2 2.8 7.4 4.2 1.8 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain TTL PF03133.13 T216035_1 - 5.5e-36 124.1 0.2 8.4e-36 123.5 0.2 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family PDEase_I PF00233.17 T046297_2 - 9.3e-82 274.2 4.4 9.3e-82 274.2 4.4 1.7 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 T046297_2 - 1.7e-22 80.2 0.0 1.3e-12 48.2 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.4 T046297_2 - 1.8e-06 28.2 0.0 0.0094 16.1 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.4 T046297_2 - 2e-05 24.8 0.0 0.14 12.4 0.0 2.6 2 1 0 2 2 2 2 GAF domain SpoVT_C PF15714.3 T046297_2 - 0.048 13.6 0.0 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 Stage V sporulation protein T C-terminal, transcription factor C2 PF00168.28 T154614_3 - 9.6e-27 93.2 0.0 4.7e-12 46.0 0.0 3.6 2 1 0 2 2 2 2 C2 domain Membr_traf_MHD PF10540.7 T154614_3 - 5.6e-21 75.2 4.8 1.4e-12 48.0 0.0 2.5 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain GRAM PF02893.18 T154614_3 - 6.7e-14 51.6 0.0 1.3e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.6 T154614_3 - 0.0026 17.8 0.0 0.0053 16.8 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 DUF1394 PF07159.10 T351694_3 - 1.6e-146 487.2 0.2 2.1e-146 486.8 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) 7tm_1 PF00001.19 T062511_1 - 9.5e-09 34.7 22.6 2.7e-08 33.3 22.6 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.19 T062511_2 - 3e-06 26.5 15.6 6.9e-06 25.4 15.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CECR6_TMEM121 PF14997.4 T062511_2 - 0.034 13.8 2.1 0.054 13.2 2.1 1.2 1 0 0 1 1 1 0 CECR6/TMEM121 family 7TM_GPCR_Srx PF10328.7 T062511_2 - 0.037 13.2 7.4 0.053 12.7 7.4 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx zf-H2C2_2 PF13465.4 T139072_1 - 0.0061 16.8 0.1 0.0061 16.8 0.1 4.1 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.24 T139072_1 - 0.19 12.1 0.0 0.19 12.1 0.0 5.1 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T139072_3 - 1.4e-06 28.4 0.7 1.7e-05 24.9 0.3 2.9 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.24 T139072_3 - 5.8e-06 26.3 6.4 0.0022 18.2 0.6 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T139072_3 - 0.0093 16.6 4.3 0.25 12.2 0.7 3.8 2 0 0 2 2 2 1 C2H2-type zinc finger ACC_central PF08326.10 T146217_3 - 3.2e-284 944.5 8.4 3.9e-284 944.2 8.4 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.20 T146217_3 - 2.8e-184 613.3 0.0 3.7e-184 612.9 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.15 T146217_3 - 3.4e-54 183.4 0.0 6.7e-54 182.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.20 T146217_3 - 4.2e-31 107.6 0.0 8.3e-31 106.7 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.17 T146217_3 - 1.8e-22 79.4 0.0 8.7e-22 77.1 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.20 T146217_3 - 4.2e-17 61.6 0.1 1.2e-16 60.1 0.1 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.4 T146217_3 - 5e-07 28.6 0.0 0.0053 15.4 0.0 2.9 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.11 T146217_3 - 8e-06 25.4 0.0 1.9e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.20 T146217_3 - 9.4e-06 25.2 0.0 1.9e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.12 T146217_3 - 5.8e-05 23.0 0.0 0.00014 21.8 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain DUF445 PF04286.10 T146217_3 - 1.2 8.7 4.0 6 6.4 0.4 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF445) LMBR1 PF04791.14 T078039_1 - 3.1e-74 250.6 22.6 6.8e-47 160.4 7.7 3.1 3 0 0 3 3 3 3 LMBR1-like membrane protein SH PF01445.15 T078039_1 - 0.072 12.9 0.0 0.34 10.8 0.0 2.2 1 0 0 1 1 1 0 Viral small hydrophobic protein Oxidored_q4 PF00507.17 T078039_1 - 0.092 12.8 3.2 0.21 11.6 3.2 1.6 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 TMEM117 PF15113.4 T077250_2 - 3.2e-231 767.3 28.5 4.3e-231 766.8 28.5 1.2 1 0 0 1 1 1 1 TMEM117 protein family RRM_1 PF00076.20 T347044_2 - 1.4e-10 40.7 0.0 2.3e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XhlA PF10779.7 T347044_2 - 0.14 12.3 6.0 0.24 11.5 6.0 1.4 1 0 0 1 1 1 0 Haemolysin XhlA FtsH_ext PF06480.13 T347044_2 - 3.9 7.7 4.9 1.3e+02 2.8 0.0 2.6 2 0 0 2 2 2 0 FtsH Extracellular TRPM_tetra PF16519.3 T360137_3 - 1.1e-23 82.9 5.4 2.2e-23 82.0 5.4 1.5 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.29 T360137_3 - 1.3e-17 63.7 17.4 1.3e-17 63.7 17.4 1.7 2 0 0 2 2 2 1 Ion transport protein DUF3552 PF12072.6 T360137_3 - 0.067 12.5 4.2 0.14 11.5 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Sarcoglycan_2 PF05510.11 T328470_2 - 7.2e-122 406.7 0.0 9.5e-122 406.3 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon Het-C PF07217.9 T328470_2 - 0.17 10.3 0.0 0.25 9.7 0.0 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Guanylate_kin PF00625.19 T148331_2 - 1.5e-44 151.7 0.0 2.2e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Guanylate kinase L27 PF02828.14 T148331_2 - 3.6e-27 93.8 4.3 1.8e-15 56.3 2.0 2.5 2 0 0 2 2 2 2 L27 domain SH3_2 PF07653.15 T148331_2 - 1e-09 37.8 0.0 2.7e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain PDZ PF00595.22 T148331_2 - 9.7e-08 32.1 0.6 2e-07 31.1 0.6 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_1 PF00018.26 T148331_2 - 1.1e-05 24.7 0.0 3.1e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 SH3 domain PDZ_2 PF13180.4 T148331_2 - 0.00034 20.7 0.1 0.00064 19.9 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 T148331_2 - 0.0054 16.6 0.0 0.021 14.7 0.0 2.0 2 0 0 2 2 2 1 Tricorn protease PDZ domain SH3_9 PF14604.4 T148331_2 - 0.023 14.4 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain LRR_8 PF13855.4 T108409_3 - 9.1e-29 98.9 28.6 3.2e-11 42.7 6.1 5.1 3 1 3 6 6 6 5 Leucine rich repeat LRR_4 PF12799.5 T108409_3 - 9.1e-13 48.0 26.9 0.0014 18.8 0.4 6.6 4 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 T108409_3 - 7e-09 35.6 0.2 0.014 15.2 0.0 3.1 2 1 0 3 3 3 2 Leucine rich repeats (6 copies) fn3 PF00041.19 T108409_3 - 4.1e-05 23.7 0.0 8.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain LRR_9 PF14580.4 T108409_3 - 4.2e-05 23.0 8.9 0.075 12.4 0.1 3.2 2 1 1 3 3 3 3 Leucine-rich repeat LRRNT PF01462.16 T108409_3 - 0.00036 20.0 2.8 0.00036 20.0 2.8 3.2 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRRCT PF01463.22 T108409_3 - 0.008 16.5 0.1 0.008 16.5 0.1 2.6 3 0 0 3 3 3 1 Leucine rich repeat C-terminal domain LRR_6 PF13516.4 T108409_3 - 1.3 9.1 15.4 5.5 7.2 0.2 5.9 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.31 T108409_3 - 4.1 8.1 15.0 5.9 7.6 0.3 6.6 7 0 0 7 7 7 0 Leucine Rich Repeat Spatacsin_C PF14649.4 T115759_3 - 2.8e-102 341.8 4.5 7.2e-102 340.4 4.5 1.7 1 0 0 1 1 1 1 Spatacsin C-terminus TSNAXIP1_N PF15739.3 T134840_2 - 1.7e-05 25.0 2.3 1.7e-05 25.0 2.3 3.4 3 1 0 3 3 3 1 Translin-associated factor X-interacting N-terminus DUF4407 PF14362.4 T134840_2 - 1.1 8.4 6.1 3 7.0 6.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4600 PF15372.4 T134840_2 - 1.8 8.9 21.9 0.44 10.8 2.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4600) MRP-L47 PF06984.11 T134840_2 - 2.5 8.1 7.4 6.4 6.8 0.2 3.4 3 0 0 3 3 3 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) TNRC6-PABC_bdg PF16608.3 T234112_3 - 2.7e-109 365.3 27.0 2.7e-109 365.3 27.0 7.6 6 2 1 7 7 7 1 TNRC6-PABC binding domain Ago_hook PF10427.7 T234112_3 - 2.6e-19 70.2 37.8 2.6e-19 70.2 37.8 9.5 3 2 4 8 8 8 1 Argonaute hook RRM_occluded PF16842.3 T234112_3 - 0.00062 19.4 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_1 PF00076.20 T234112_3 - 0.0018 17.9 0.0 0.0048 16.5 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRO1 PF03097.16 T031125_2 - 1.3e-14 53.7 0.0 1.8e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 BRO1-like domain BRO1 PF03097.16 T031125_3 - 6.2e-21 74.5 0.8 9.1e-21 74.0 0.8 1.1 1 0 0 1 1 1 1 BRO1-like domain Trypsin PF00089.24 T179430_1 - 2.5e-68 230.1 0.0 3.5e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 T179430_1 - 0.011 16.0 0.0 0.023 15.0 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) Jnk-SapK_ap_N PF09744.7 T125080_1 - 1.7e-56 190.7 23.9 2.1e-56 190.3 23.9 1.1 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 Atg14 PF10186.7 T125080_1 - 0.007 15.4 9.2 0.011 14.7 9.2 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1759 PF03564.13 T125080_1 - 1.1 9.0 4.2 1.7 8.5 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) DUF737 PF05300.9 T125080_1 - 7.1 6.8 25.1 16 5.7 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF737) JIP_LZII PF16471.3 T125080_3 - 1.8e-28 98.4 9.3 1.8e-28 98.4 9.3 1.8 2 0 0 2 2 2 1 JNK-interacting protein leucine zipper II Rootletin PF15035.4 T125080_3 - 0.00053 20.0 1.7 0.00053 20.0 1.7 1.5 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion GreA_GreB_N PF03449.13 T125080_3 - 0.013 15.5 1.5 0.029 14.4 1.5 1.5 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal RILP PF11461.6 T125080_3 - 0.047 13.8 6.1 0.059 13.5 0.3 2.5 2 0 0 2 2 2 0 Rab interacting lysosomal protein Med21 PF11221.6 T125080_3 - 0.051 13.7 1.5 0.13 12.4 1.5 1.6 1 0 0 1 1 1 0 Subunit 21 of Mediator complex Taxilin PF09728.7 T125080_3 - 0.093 11.8 8.9 0.14 11.3 8.9 1.1 1 0 0 1 1 1 0 Myosin-like coiled-coil protein Atg14 PF10186.7 T125080_3 - 2.1 7.2 7.5 3.6 6.4 7.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6 PF04111.10 T125080_3 - 3 7.0 6.0 5 6.3 6.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 T125080_3 - 4.1 7.0 5.5 7.1 6.2 5.5 1.3 1 0 0 1 1 1 0 IncA protein Homeobox PF00046.27 T041770_3 - 8.9e-17 60.5 11.0 2.5e-13 49.5 0.8 2.5 2 0 0 2 2 2 2 Homeobox domain OAR PF03826.15 T041770_3 - 1.1e-06 28.1 0.7 2.8e-06 26.8 0.7 1.7 1 0 0 1 1 1 1 OAR domain G2F PF07474.10 T104434_2 - 8.5e-67 224.3 0.0 1.3e-66 223.7 0.0 1.3 1 0 0 1 1 1 1 G2F domain Thyroglobulin_1 PF00086.16 T104434_2 - 3e-34 116.4 18.1 5.3e-17 61.1 4.1 3.1 2 0 0 2 2 2 2 Thyroglobulin type-1 repeat Ldl_recept_b PF00058.15 T104434_2 - 6.7e-30 103.2 0.1 1.6e-12 47.5 0.0 4.0 4 0 0 4 4 4 3 Low-density lipoprotein receptor repeat class B EGF_3 PF12947.5 T104434_2 - 1.2e-25 89.3 83.5 7.9e-09 35.4 9.9 5.8 5 0 0 5 5 5 5 EGF domain NIDO PF06119.12 T104434_2 - 4.7e-23 81.9 0.0 1.1e-22 80.7 0.0 1.7 1 0 0 1 1 1 1 Nidogen-like cEGF PF12662.5 T104434_2 - 1e-18 66.8 34.6 7.2e-07 28.9 1.4 5.1 4 0 0 4 4 4 4 Complement Clr-like EGF-like EGF_CA PF07645.13 T104434_2 - 1.9e-16 59.8 86.7 4.3e-09 36.3 8.0 6.3 6 0 0 6 6 6 4 Calcium-binding EGF domain EGF PF00008.25 T104434_2 - 6.4e-06 26.2 75.9 0.0088 16.2 10.9 6.3 5 0 0 5 5 5 4 EGF-like domain FXa_inhibition PF14670.4 T104434_2 - 5.7e-05 23.2 7.3 5.7e-05 23.2 7.3 6.2 6 0 0 6 6 6 3 Coagulation Factor Xa inhibitory site SGL PF08450.10 T104434_2 - 0.00078 19.0 0.0 0.056 12.9 0.0 2.6 1 1 2 3 3 3 1 SMP-30/Gluconolaconase/LRE-like region hEGF PF12661.5 T104434_2 - 0.0095 16.5 62.5 0.014 15.9 6.1 6.7 6 0 0 6 6 5 4 Human growth factor-like EGF EGF_MSP1_1 PF12946.5 T104434_2 - 0.5 10.3 54.5 0.17 11.8 0.3 5.7 5 0 0 5 5 5 0 MSP1 EGF domain 1 Ldh_1_N PF00056.21 T055715_1 - 1.8e-50 170.5 5.7 3.1e-49 166.6 0.7 2.2 2 0 0 2 2 2 2 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 T055715_1 - 7.3e-23 81.2 0.0 1.2e-22 80.5 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Pyr_redox_2 PF07992.12 T055715_1 - 0.0048 16.1 0.0 0.26 10.4 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Ldh_1_C PF02866.16 T055715_2 - 6.7e-07 29.2 0.0 9.8e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.21 T055715_3 - 2e-25 89.4 0.1 2.8e-25 88.9 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 T055715_3 - 0.00013 21.8 0.0 0.00018 21.3 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 T055715_3 - 0.15 11.4 0.1 0.25 10.7 0.1 1.2 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase Prolamin_like PF05617.9 T152183_1 - 0.0082 16.2 0.1 0.027 14.5 0.1 1.9 1 0 0 1 1 1 1 Prolamin-like AAA PF00004.27 T152183_3 - 1.1e-42 145.5 0.0 2.1e-42 144.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.12 T152183_3 - 4.4e-07 30.1 0.0 9.5e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.12 T152183_3 - 6e-06 26.2 0.0 2.6e-05 24.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 T152183_3 - 8.8e-06 26.1 0.1 0.00011 22.5 0.0 2.5 2 1 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.4 T152183_3 - 6.9e-05 23.0 1.6 0.016 15.4 0.0 2.9 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.10 T152183_3 - 0.00016 20.9 0.0 0.00029 20.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.11 T152183_3 - 0.0025 16.7 0.0 0.0047 15.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.15 T152183_3 - 0.0027 17.3 0.0 0.0057 16.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.4 T152183_3 - 0.0028 17.7 0.0 0.0057 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 T152183_3 - 0.0052 17.2 0.2 0.03 14.7 0.0 2.3 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.19 T152183_3 - 0.01 15.1 0.1 0.023 13.9 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.9 T152183_3 - 0.011 15.5 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.11 T152183_3 - 0.015 14.5 0.0 0.035 13.3 0.0 1.6 1 0 0 1 1 1 0 KaiC PhoH PF02562.14 T152183_3 - 0.016 14.6 0.0 0.19 11.0 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.4 T152183_3 - 0.03 14.4 0.0 0.059 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain RILP PF11461.6 T152183_3 - 0.035 14.2 3.4 0.075 13.1 3.4 1.6 1 0 0 1 1 1 0 Rab interacting lysosomal protein Sigma54_activat PF00158.24 T152183_3 - 0.038 13.5 0.0 0.17 11.5 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.4 T152183_3 - 0.047 13.3 0.0 0.098 12.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain TsaE PF02367.15 T152183_3 - 0.065 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.15 T152183_3 - 0.07 12.1 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.4 T152183_3 - 0.079 12.4 0.0 0.24 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.4 T152183_3 - 0.096 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 T152183_3 - 0.099 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_11 PF13086.4 T152183_3 - 0.15 11.7 0.6 0.6 9.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Laminin_II PF06009.10 T152183_3 - 0.71 9.7 4.0 1.9 8.4 0.9 2.6 3 0 0 3 3 3 0 Laminin Domain II E1-E2_ATPase PF00122.18 T004382_1 - 2.3e-24 85.8 0.0 3.3e-24 85.3 0.0 1.1 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.6 T004382_1 - 2.6e-23 82.4 0.0 4.9e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.24 T004382_2 - 2.3e-15 57.3 0.0 1.1e-09 38.8 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.18 T004382_2 - 1.1e-06 28.0 0.3 2.2e-06 27.0 0.3 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.4 T004382_2 - 0.0019 18.1 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 Cation transport ATPase (P-type) ABC_membrane PF00664.21 T097744_2 - 4.7e-76 255.9 37.6 8.8e-46 156.6 10.7 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 T097744_2 - 8.2e-55 184.9 0.2 8.7e-30 103.9 0.1 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 T097744_2 - 1.1e-10 41.2 1.9 0.023 14.0 0.1 4.2 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.21 T097744_2 - 1e-06 28.7 0.0 0.0049 16.8 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.4 T097744_2 - 3.2e-06 26.6 0.4 0.071 12.7 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.4 T097744_2 - 6.3e-06 26.1 1.4 0.69 9.5 0.2 4.2 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.4 T097744_2 - 6.7e-06 26.4 0.2 0.018 15.3 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.14 T097744_2 - 1.2e-05 25.1 0.1 0.13 12.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Dynamin_N PF00350.21 T097744_2 - 0.00053 20.0 0.1 0.26 11.2 0.2 2.5 2 0 0 2 2 2 2 Dynamin family AAA_22 PF13401.4 T097744_2 - 0.0072 16.5 0.9 3.6 7.7 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.4 T097744_2 - 0.012 15.2 0.2 2.3 7.7 0.0 2.7 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.15 T097744_2 - 0.015 14.9 0.6 2.5 7.7 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_23 PF13476.4 T097744_2 - 0.017 15.5 0.1 1.7 9.0 0.1 2.3 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.18 T097744_2 - 0.085 11.8 0.0 2 7.2 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.17 T097744_2 - 0.19 11.2 0.7 5.4 6.4 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain bZIP_1 PF00170.19 T061435_1 - 9.8e-07 28.7 16.2 1.4e-06 28.2 16.2 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.15 T061435_1 - 8.5e-05 22.9 10.0 0.00013 22.3 10.0 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.13 T061435_1 - 0.00017 21.4 14.8 0.00027 20.8 14.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper DUF3450 PF11932.6 T061435_1 - 0.067 12.3 1.1 0.1 11.8 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Macoilin PF09726.7 T061435_1 - 0.4 9.0 5.9 0.56 8.6 5.9 1.1 1 0 0 1 1 1 0 Transmembrane protein APG6 PF04111.10 T061435_1 - 2.4 7.4 5.8 3.3 6.9 5.8 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Mnd1 PF03962.13 T061435_1 - 3.5 7.3 5.8 5.3 6.7 5.8 1.1 1 0 0 1 1 1 0 Mnd1 family IncA PF04156.12 T061435_1 - 8.9 5.9 7.9 14 5.3 7.9 1.1 1 0 0 1 1 1 0 IncA protein I-set PF07679.14 T066260_2 - 3.2e-80 264.2 0.0 1.5e-15 56.9 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_3 PF13927.4 T066260_2 - 2.5e-77 255.4 0.4 9.5e-14 51.6 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain Ig_2 PF13895.4 T066260_2 - 8.7e-57 189.3 0.1 6.1e-11 42.4 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 T066260_2 - 4e-44 148.5 0.0 1.8e-09 37.5 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.19 T066260_2 - 1.7e-39 133.9 9.5 2.5e-13 50.0 0.1 4.5 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.15 T066260_2 - 3e-21 75.5 7.3 0.0055 16.7 0.0 10.4 7 5 2 9 9 8 5 Immunoglobulin V-set domain Ig_5 PF16681.3 T066260_2 - 1.7e-09 37.8 0.0 0.28 11.5 0.0 5.8 6 0 0 6 6 6 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 T066260_2 - 5.5e-08 32.6 0.1 1.1 9.3 0.0 5.1 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 T066260_2 - 4e-07 30.1 0.0 2.5 8.4 0.0 4.6 4 0 0 4 4 4 3 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 T066260_2 - 0.00031 20.6 0.0 18 5.3 0.0 5.4 6 0 0 6 6 6 0 Izumo-like Immunoglobulin domain Pur_ac_phosph_N PF16656.3 T066260_2 - 0.00063 20.1 0.1 0.14 12.6 0.0 2.6 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain C2-set PF05790.13 T066260_2 - 0.00073 19.5 0.0 0.45 10.6 0.0 3.7 4 0 0 4 4 4 1 Immunoglobulin C2-set domain Herpes_gE PF02480.14 T066260_2 - 0.0091 14.7 0.1 3.1 6.3 0.0 3.2 3 1 1 4 4 4 1 Alphaherpesvirus glycoprotein E Vinculin PF01044.17 T192567_1 - 6e-104 349.0 11.2 1.5e-103 347.7 11.2 1.5 1 1 0 1 1 1 1 Vinculin family SAWADEE PF16719.3 T192567_1 - 0.067 13.1 0.8 0.21 11.5 0.1 2.1 2 0 0 2 2 2 0 SAWADEE domain DUF4719 PF15843.3 T192567_1 - 0.068 13.1 0.2 0.14 12.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) Rotamase PF00639.19 T192567_1 - 0.12 13.2 1.6 1.4 9.8 0.2 2.7 2 1 0 2 2 2 0 PPIC-type PPIASE domain CorA PF01544.16 T192567_1 - 0.21 10.7 2.9 0.26 10.5 0.4 2.2 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Trns_repr_metal PF02583.15 T192567_1 - 0.36 11.1 7.5 3.1 8.1 0.1 3.6 3 1 0 3 3 3 0 Metal-sensitive transcriptional repressor NAM-associated PF14303.4 T192567_1 - 1.3 9.5 4.9 3 8.3 4.9 1.7 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF3498 PF12004.6 T365952_1 - 1.6e-194 647.8 9.4 3.1e-194 646.9 9.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3498) RasGAP PF00616.17 T365952_1 - 1e-26 93.8 4.9 2.4e-14 53.4 0.1 2.9 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.28 T365952_1 - 1.6e-07 31.4 0.0 2.6e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 C2 domain Bacillus_HBL PF05791.9 T365952_1 - 0.00028 20.5 5.0 0.00051 19.7 5.0 1.3 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) PH_2 PF08458.8 T365952_1 - 0.021 15.0 0.0 0.045 14.0 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH PF00169.27 T365952_1 - 0.033 14.5 0.3 0.091 13.1 0.0 1.9 2 0 0 2 2 2 0 PH domain Med4 PF10018.7 T365952_1 - 0.49 9.9 6.0 0.97 8.9 6.0 1.5 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 EMP24_GP25L PF01105.22 T365952_1 - 1.6 8.5 4.0 2.9 7.7 4.0 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Gly_acyl_tr_N PF06021.9 T365952_1 - 2 8.3 4.6 3.4 7.6 4.6 1.3 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase XLF PF09302.9 T365952_1 - 7.4 6.6 7.0 16 5.5 7.0 1.4 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF4587 PF15248.4 T228340_1 - 5.4e-17 62.2 10.9 2.6e-16 60.1 10.9 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4587) FTCD_N PF07837.10 T205532_2 - 7.1e-29 100.7 0.0 9.5e-29 100.3 0.0 1.1 1 0 0 1 1 1 1 Formiminotransferase domain, N-terminal subdomain DNA_ligase_A_M PF01068.19 T098788_3 - 5.2e-57 192.7 0.2 1.1e-56 191.6 0.2 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 T098788_3 - 9e-42 143.2 0.4 1.5e-41 142.4 0.4 1.4 1 0 0 1 1 1 1 DNA ligase N terminus BRCT PF00533.24 T098788_3 - 4.1e-18 65.4 0.1 7.2e-10 39.0 0.0 2.9 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain DNA_ligase_IV PF11411.6 T098788_3 - 8.2e-17 60.9 1.1 8.2e-17 60.9 1.1 2.1 2 0 0 2 2 2 1 DNA ligase IV DNA_ligase_A_C PF04679.13 T098788_3 - 9.8e-16 58.0 0.0 2.2e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.3 T098788_3 - 5e-14 52.3 0.1 4e-09 36.6 0.0 2.7 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.8 T098788_3 - 4.4e-09 36.7 0.1 7.6e-09 35.9 0.1 1.4 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.17 T098788_3 - 0.014 15.1 0.8 0.17 11.6 0.8 2.2 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain APG17 PF04108.10 T098788_3 - 0.036 13.0 2.1 0.056 12.4 0.4 2.1 3 0 0 3 3 3 0 Autophagy protein Apg17 EGF_CA PF07645.13 T061288_2 - 1.1e-17 63.8 60.3 6.2e-09 35.8 3.1 5.0 5 0 0 5 5 5 4 Calcium-binding EGF domain TB PF00683.15 T061288_2 - 1.6e-08 34.0 13.3 4.7e-08 32.5 13.3 1.9 1 0 0 1 1 1 1 TB domain cEGF PF12662.5 T061288_2 - 1.5e-07 31.1 31.6 3.2e-05 23.6 0.3 5.3 5 0 0 5 5 5 3 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.9 T061288_2 - 0.00011 22.2 25.1 0.018 15.2 1.1 3.7 3 0 0 3 3 3 3 Pvs28 EGF domain EGF_3 PF12947.5 T061288_2 - 0.0011 19.0 37.0 0.015 15.3 5.3 5.3 4 1 0 4 4 4 3 EGF domain FXa_inhibition PF14670.4 T061288_2 - 0.0085 16.2 5.4 0.0085 16.2 5.4 5.6 6 0 0 6 6 6 4 Coagulation Factor Xa inhibitory site hEGF PF12661.5 T061288_2 - 0.011 16.3 1.5 0.011 16.3 1.5 6.6 7 1 1 8 8 8 0 Human growth factor-like EGF EGF_CA PF07645.13 T061288_3 - 2.6e-63 209.8 103.7 2.8e-09 36.9 5.0 8.7 8 0 0 8 8 8 8 Calcium-binding EGF domain cEGF PF12662.5 T061288_3 - 3.8e-52 173.7 60.4 1.1e-09 37.9 0.6 9.2 9 0 0 9 9 9 8 Complement Clr-like EGF-like FXa_inhibition PF14670.4 T061288_3 - 2.8e-22 78.6 104.6 0.0006 19.9 7.3 9.0 5 2 3 8 8 8 8 Coagulation Factor Xa inhibitory site EGF PF00008.25 T061288_3 - 7.3e-18 64.4 114.7 0.00015 21.9 5.1 9.7 8 0 0 8 8 8 7 EGF-like domain hEGF PF12661.5 T061288_3 - 2.3e-14 53.3 124.4 0.00075 19.9 3.1 10.7 10 1 0 10 10 10 8 Human growth factor-like EGF TB PF00683.15 T061288_3 - 4.6e-13 48.5 3.9 4.6e-13 48.5 3.9 3.6 3 0 0 3 3 3 1 TB domain EGF_3 PF12947.5 T061288_3 - 4.2e-11 42.7 88.1 0.0006 19.8 1.8 9.2 8 1 0 8 8 8 7 EGF domain Plasmod_Pvs28 PF06247.9 T061288_3 - 0.0011 19.0 76.4 0.0032 17.6 1.3 8.9 8 1 1 9 9 9 5 Pvs28 EGF domain EGF_2 PF07974.11 T061288_3 - 0.34 11.2 113.3 0.048 13.9 3.4 9.4 7 1 1 8 8 8 0 EGF-like domain zf-C2H2_assoc3 PF16637.3 T232302_1 - 1.5e-33 114.8 5.4 3.7e-33 113.6 5.4 1.7 1 0 0 1 1 1 1 Putative zinc-finger between two C2H2 zinc-fingers on Patz BTB PF00651.29 T232302_1 - 1.8e-25 89.2 0.0 2.7e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 T232302_1 - 2.4e-21 74.4 23.5 0.0017 18.9 0.3 6.2 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2 PF00096.24 T232302_1 - 5.7e-16 57.9 43.3 0.00023 21.3 0.8 6.9 7 0 0 7 7 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T232302_1 - 1.6e-11 44.0 33.9 1e-05 25.6 2.3 7.1 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_jaz PF12171.6 T232302_1 - 6.9e-07 29.3 13.7 0.82 9.9 0.4 5.9 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T232302_1 - 3.4e-06 27.1 11.5 1.7 9.0 0.0 5.5 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-Di19 PF05605.10 T232302_1 - 0.004 17.3 11.1 0.14 12.3 0.5 4.2 3 1 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 T232302_1 - 0.0067 16.2 21.8 0.011 15.5 0.3 5.6 5 0 0 5 5 5 1 C2H2-type zinc finger ARS2 PF04959.11 T232302_1 - 0.36 11.0 7.0 0.37 11.0 0.1 3.2 3 1 1 4 4 4 0 Arsenite-resistance protein 2 Zn-ribbon_8 PF09723.8 T232302_1 - 0.66 10.0 22.3 0.15 12.0 0.5 5.1 5 0 0 5 5 5 0 Zinc ribbon domain GAGA PF09237.9 T232302_1 - 2.6 7.8 10.7 31 4.3 0.7 4.6 3 1 1 4 4 4 0 GAGA factor zf-BED PF02892.13 T232302_1 - 5.9 6.9 11.2 26 4.8 0.2 4.5 5 0 0 5 5 5 0 BED zinc finger zf-C2H2_6 PF13912.4 T232302_3 - 0.026 14.3 0.2 0.026 14.3 0.2 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger GlcNAc_2-epim PF07221.9 T150527_1 - 0.0061 15.7 0.2 0.12 11.4 0.0 2.0 2 0 0 2 2 2 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) C5-epim_C PF06662.11 T150527_1 - 0.25 10.7 0.1 0.43 9.9 0.1 1.3 1 0 0 1 1 1 0 D-glucuronyl C5-epimerase C-terminus Thioredox_DsbH PF03190.13 T150527_2 - 1.2e-72 243.1 0.0 1.8e-72 242.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.4 T150527_2 - 6.6e-11 42.1 0.0 1.2e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.4 T150527_2 - 0.033 14.5 0.0 0.056 13.8 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain CEP170_C PF15308.4 T111584_2 - 5.2e-282 937.3 40.9 2.7e-153 511.9 28.7 2.3 1 1 1 2 2 2 2 CEP170 C-terminus FHA PF00498.24 T111584_2 - 8.9e-17 61.1 0.1 2.2e-16 59.8 0.1 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.3 T111584_2 - 1e-08 35.2 0.0 2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain PLU-1 PF08429.9 T111584_2 - 0.086 11.8 0.4 0.13 11.2 0.4 1.2 1 0 0 1 1 1 0 PLU-1-like protein Syntaxin_2 PF14523.4 T111584_2 - 0.24 11.6 1.3 1.5 9.1 1.2 2.0 2 0 0 2 2 2 0 Syntaxin-like protein CTNNB1_binding PF08347.9 T269244_3 - 2e-70 237.0 5.1 2e-70 237.0 5.1 1.9 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 T269244_3 - 1.5e-21 76.5 0.7 4.5e-21 74.9 0.7 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T269244_3 - 1.4e-07 31.8 0.8 1.4e-07 31.8 0.8 1.9 2 0 0 2 2 2 1 HMG-box domain JmjC PF02373.20 T362722_2 - 2.7e-11 43.8 0.1 6.1e-11 42.6 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase RVT_1 PF00078.25 T362722_2 - 8.5e-11 41.6 0.1 1.6e-10 40.7 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PHD PF00628.27 T362722_2 - 1.7e-08 34.1 7.5 5e-08 32.6 7.5 1.9 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.4 T362722_2 - 8.9e-07 28.8 0.0 1.8e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Cupin-like domain PHD_2 PF13831.4 T362722_2 - 0.14 11.6 2.2 0.35 10.3 2.2 1.8 1 0 0 1 1 1 0 PHD-finger DUF1725 PF08333.9 T362722_3 - 0.75 9.4 2.4 1.6 8.3 2.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) G_glu_transpept PF01019.19 T216610_1 - 7e-14 51.3 0.1 9.5e-14 50.9 0.1 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase SP_C-Propep PF08999.8 T216610_1 - 0.5 10.0 2.1 0.89 9.2 2.1 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide G_glu_transpept PF01019.19 T216610_2 - 9.3e-87 291.8 0.0 1.2e-74 251.8 0.0 2.1 2 0 0 2 2 2 2 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.19 T216610_3 - 1.3e-21 76.9 0.0 1.8e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Vasohibin PF14822.4 T030192_1 - 3.8e-121 402.8 0.2 5e-121 402.4 0.2 1.1 1 0 0 1 1 1 1 Vasohibin DUF4587 PF15248.4 T228323_3 - 1.1e-15 58.0 0.3 2.3e-15 57.0 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4587) DED PF01335.19 T205809_2 - 7.8e-43 144.5 18.7 3.4e-22 78.4 6.6 2.3 2 0 0 2 2 2 2 Death effector domain Popeye PF04831.11 T205809_2 - 0.89 9.6 6.7 1.9 8.5 6.7 1.4 1 0 0 1 1 1 0 Popeye protein conserved region PYRIN PF02758.14 T205809_2 - 4 7.6 5.8 0.45 10.6 0.3 2.1 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain Peptidase_C14 PF00656.20 T205809_3 - 5.3e-46 157.5 0.0 7.1e-46 157.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain COesterase PF00135.26 T134121_1 - 6e-33 114.4 0.0 8.2e-33 114.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.26 T134121_2 - 3.5e-118 395.6 0.0 4.6e-118 395.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 T134121_2 - 5.6e-10 39.3 0.5 1.2e-09 38.3 0.5 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 T134121_2 - 0.18 11.1 0.1 0.3 10.4 0.1 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Cys_knot PF00007.20 T178521_1 - 2e-32 111.5 7.9 3.8e-32 110.6 7.9 1.5 1 0 0 1 1 1 1 Cystine-knot domain Ion_trans PF00520.29 T178521_3 - 3e-45 154.2 5.6 5.1e-44 150.2 5.1 2.0 2 0 0 2 2 2 1 Ion transport protein NGF PF00243.16 T178521_3 - 4.7e-44 149.1 0.0 7.2e-44 148.5 0.0 1.3 1 0 0 1 1 1 1 Nerve growth factor family BTB_2 PF02214.20 T178521_3 - 1.2e-25 89.5 0.0 1.9e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 T178521_3 - 4.4e-11 42.5 7.1 4.4e-11 42.5 7.1 1.6 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.10 T178521_3 - 0.22 10.0 2.5 0.21 10.1 1.2 1.4 1 1 0 1 1 1 0 Polycystin cation channel V-set PF07686.15 T179648_1 - 3e-15 56.2 3.1 5.1e-12 45.8 0.1 3.8 2 2 2 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.4 T179648_1 - 2.7e-12 47.0 0.2 4.6e-07 30.2 0.0 3.3 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.14 T179648_1 - 8.4e-11 41.7 0.0 1e-06 28.6 0.0 3.2 2 2 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 T179648_1 - 1e-09 38.4 0.8 1e-07 32.0 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 T179648_1 - 9.8e-08 31.9 0.8 0.0048 16.9 0.2 3.4 2 1 0 2 2 2 2 Immunoglobulin domain Collagen PF01391.16 T301790_3 - 5.2e-151 490.4 715.7 7.5e-09 35.1 27.3 24.9 6 1 13 19 19 19 10 Collagen triple helix repeat (20 copies) COLFI PF01410.16 T301790_3 - 2.4e-58 197.1 0.0 2.5e-34 118.5 0.1 2.3 1 1 1 2 2 2 2 Fibrillar collagen C-terminal domain Hormone_recep PF00104.28 T301790_3 - 8.3e-39 133.2 0.0 1.1e-38 132.7 0.0 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 T301790_3 - 5.8e-31 106.6 16.7 1.2e-30 105.6 16.7 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Laminin_G_2 PF02210.22 T301790_3 - 3.1e-07 30.9 0.0 5.4e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Nuc_recep-AF1 PF11825.6 T301790_3 - 1.3e-05 25.1 11.8 2.9e-05 24.0 11.8 1.5 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 Laminin_G_3 PF13385.4 T301790_3 - 0.00036 20.6 0.0 0.00056 20.0 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.21 T301790_3 - 0.0097 16.0 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Beach PF02138.16 T041710_2 - 6.3e-120 399.6 0.0 9.3e-120 399.0 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.30 T041710_2 - 1.6e-07 31.7 12.4 0.0011 19.6 0.1 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat PH_BEACH PF14844.4 T041710_2 - 2.4e-06 27.5 0.4 6.2e-06 26.1 0.4 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4704 PF15787.3 T041710_2 - 4.1e-05 22.8 0.6 4.1e-05 22.8 0.6 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4704) Shisa PF13908.4 T011091_1 - 0.0001 22.5 5.9 0.0001 22.5 5.9 2.7 3 0 0 3 3 3 2 Wnt and FGF inhibitory regulator RIH_assoc PF08454.9 T114051_1 - 1.7e-30 104.7 0.2 1.7e-30 104.7 0.2 1.8 2 0 0 2 2 2 1 RyR and IP3R Homology associated Ion_trans PF00520.29 T114051_1 - 2.5e-14 53.0 3.4 4.1e-14 52.3 3.4 1.3 1 0 0 1 1 1 1 Ion transport protein RR_TM4-6 PF06459.10 T114051_2 - 9.1e-59 199.4 19.3 1e-31 110.7 7.5 2.8 2 1 1 3 3 3 2 Ryanodine Receptor TM 4-6 EF-hand_1 PF00036.30 T114051_2 - 4.1e-05 22.7 0.1 9.9e-05 21.5 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 T114051_2 - 0.00041 19.9 0.4 0.0015 18.1 0.4 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T114051_2 - 0.00052 19.6 0.1 0.0019 17.9 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.4 T114051_2 - 0.007 16.7 1.1 0.007 16.7 1.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.4 T114051_2 - 0.026 13.9 0.0 0.05 13.0 0.0 1.5 1 0 0 1 1 1 0 EF hand DUF1899 PF08953.9 T144903_2 - 1.5e-29 101.5 0.0 2.8e-29 100.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 T144903_2 - 1e-20 73.2 0.2 1.9e-20 72.3 0.2 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 T144903_2 - 7.8e-13 48.6 5.4 0.0013 19.4 0.2 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T144903_2 - 2.4e-07 30.8 0.1 0.002 18.3 0.0 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DSPc PF00782.18 T144903_3 - 8.8e-33 112.8 0.0 1.5e-32 112.0 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.9 T144903_3 - 4.9e-10 39.1 5.1 8.8e-10 38.2 5.1 1.4 1 0 0 1 1 1 1 DEK C terminal domain PTPLA PF04387.12 T037879_1 - 1.5e-24 86.5 6.6 2.5e-24 85.8 6.6 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA PTPLA PF04387.12 T037879_2 - 1.6e-27 96.1 2.0 2.4e-27 95.6 2.0 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Cwf_Cwc_15 PF04889.10 T037879_2 - 0.57 9.7 4.0 0.9 9.1 4.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Ank_2 PF12796.5 T099203_3 - 4.9e-25 87.8 0.1 5.1e-11 42.9 0.0 3.3 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T099203_3 - 1.3e-17 63.8 1.3 3.3e-08 33.8 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 T099203_3 - 6.7e-15 53.6 0.8 0.0088 16.4 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.28 T099203_3 - 3.4e-14 52.4 1.0 0.011 16.0 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.4 T099203_3 - 3.3e-10 39.9 4.3 6.7e-05 23.0 0.0 5.2 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Fez1 PF06818.13 T047438_2 - 9.1e-68 228.5 19.4 9.1e-68 228.5 19.4 2.2 2 0 0 2 2 2 1 Fez1 DUF4250 PF14056.4 T047438_2 - 0.084 12.7 0.3 0.81 9.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) DUF3287 PF11690.6 T047438_2 - 2.1 7.9 7.7 0.47 10.1 2.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) Adaptin_binding PF10199.7 T047438_2 - 3.5 8.1 12.5 1.2 9.6 2.3 2.6 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Tropomyosin PF00261.18 T117812_1 - 3.4e-94 314.5 85.4 7.5e-92 306.8 61.6 2.1 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 T117812_1 - 7.5e-38 129.7 72.3 2.2e-35 121.8 40.9 2.5 1 1 1 2 2 2 2 Tropomyosin like CLZ PF16526.3 T117812_1 - 0.00018 21.7 46.0 0.00079 19.6 10.5 4.5 3 1 1 4 4 4 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.10 T117812_1 - 0.0026 17.7 8.4 0.0026 17.7 8.4 3.6 1 1 3 4 4 4 2 Laminin Domain II IncA PF04156.12 T117812_1 - 2 8.0 58.9 0.018 14.7 23.4 2.4 1 1 0 2 2 2 0 IncA protein DUF1664 PF07889.10 T117812_1 - 4 7.3 24.7 1.1 9.2 4.3 3.3 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) E2F_CC-MB PF16421.3 T184680_3 - 1.5e-31 108.5 0.5 2.3e-31 108.0 0.5 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.18 T184680_3 - 9.5e-23 79.9 0.1 1.7e-22 79.1 0.1 1.4 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.17 T184680_3 - 0.12 12.2 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB BK_channel_a PF03493.16 T027258_1 - 4.1e-31 107.0 0.1 1.4e-30 105.3 0.1 2.0 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.14 T027258_1 - 1.3e-13 50.5 4.1 5.9e-13 48.5 3.9 2.2 2 0 0 2 2 2 1 Ion channel Anophelin PF10731.7 T027258_1 - 0.11 12.3 0.7 0.24 11.1 0.7 1.6 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito Mito_carr PF00153.25 T228844_3 - 9.3e-59 195.2 2.7 7e-24 83.4 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Cadherin PF00028.15 T382916_3 - 1.3e-105 346.0 8.5 1.8e-20 73.1 0.0 7.9 8 1 1 9 9 9 7 Cadherin domain Protocadherin PF08374.9 T382916_3 - 1.7e-81 273.2 4.8 2.9e-81 272.5 4.8 1.4 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.10 T382916_3 - 1.8e-22 78.8 1.8 1.2e-08 34.5 0.0 6.0 6 0 0 6 6 6 4 Cadherin-like Cadherin_3 PF16184.3 T382916_3 - 1e-06 28.6 15.2 0.34 10.8 0.2 5.8 5 0 0 5 5 5 4 Cadherin-like DUF793 PF05633.9 T382916_3 - 0.065 12.1 0.2 0.1 11.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF793) EphA2_TM PF14575.4 T382916_3 - 0.11 13.2 0.3 0.37 11.5 0.1 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain APP_E2 PF12925.5 T070400_3 - 1.3e-68 230.3 16.2 2.6e-68 229.4 16.2 1.5 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 T070400_3 - 5.4e-41 138.9 1.2 1.3e-40 137.6 1.2 1.7 1 0 0 1 1 1 1 Amyloid A4 N-terminal heparin-binding APP_amyloid PF10515.7 T070400_3 - 9.1e-25 86.9 0.2 2.8e-24 85.3 0.2 1.9 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus APP_Cu_bd PF12924.5 T070400_3 - 7.2e-24 84.2 6.6 7.2e-24 84.2 6.6 2.4 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD Kunitz_BPTI PF00014.21 T070400_3 - 6.3e-20 71.0 4.2 2.3e-19 69.2 4.2 2.1 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain MIP-T3 PF10243.7 T106103_2 - 0.17 10.5 14.9 0.23 10.0 14.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Vfa1 PF08432.8 T106103_2 - 6.1 7.0 13.0 11 6.2 13.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Rootletin PF15035.4 T004313_1 - 1.4e-64 217.5 25.4 1.4e-64 217.5 25.4 7.7 3 1 4 7 7 7 1 Ciliary rootlet component, centrosome cohesion Keratin_matx PF04579.10 T147292_2 - 2.2e-48 162.4 34.9 3.7e-48 161.7 34.9 1.4 1 0 0 1 1 1 1 Keratin, high-sulphur matrix protein Peptidase_S24 PF00717.21 T121235_1 - 3.1e-08 33.3 0.1 5.8e-08 32.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like Bombesin PF02044.15 T121235_2 - 1.6e-07 30.7 3.1 4.2e-07 29.4 3.1 1.8 1 0 0 1 1 1 1 Bombesin-like peptide RhoGAP PF00620.25 T203269_2 - 3.7e-50 169.6 0.0 5.6e-50 169.0 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 T203269_2 - 1.6e-15 56.6 7.5 1.6e-15 56.6 7.5 2.0 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH2 PF00017.22 T203269_2 - 5.8e-13 48.6 0.1 1.2e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 SH2 domain FYVE_2 PF02318.14 T203269_2 - 0.084 13.0 2.0 0.16 12.1 2.0 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger Sec16_C PF12931.5 T369163_1 - 1.2e-42 146.4 0.1 2.1e-42 145.7 0.1 1.3 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.5 T369163_1 - 5.4e-07 30.1 0.0 1.2e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Exo_endo_phos PF03372.21 T369163_2 - 1.3e-05 25.3 0.0 2.1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1725 PF08333.9 T073927_1 - 1.2e-05 24.7 0.1 2.6e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Pro-rich PF15240.4 T073927_3 - 2.8e-34 118.8 73.6 3.9e-34 118.3 73.6 1.2 1 0 0 1 1 1 1 Proline-rich DUF3251 PF11622.6 T003900_1 - 0.18 11.3 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Voltage_CLC PF00654.18 T003900_2 - 1.3e-59 202.1 16.0 2.3e-59 201.3 16.0 1.3 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.26 T003900_2 - 6.7e-06 26.3 0.0 0.00025 21.3 0.1 2.3 2 0 0 2 2 2 1 CBS domain Flavi_NS4A PF01350.15 T003900_2 - 0.068 13.0 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A Voltage_CLC PF00654.18 T003900_3 - 1.4e-07 30.9 3.6 2e-07 30.5 3.6 1.1 1 0 0 1 1 1 1 Voltage gated chloride channel Exo_endo_phos PF03372.21 T309392_2 - 2e-06 27.9 0.0 3.4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SRF-TF PF00319.16 T022519_3 - 8.2e-24 82.7 0.4 1.5e-23 81.8 0.4 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 T022519_3 - 1.3e-07 31.4 0.0 1.3e-07 31.4 0.0 2.7 2 1 0 2 2 2 1 Holliday junction regulator protein family C-terminal repeat DUF2360 PF10152.7 T022519_3 - 0.14 12.4 3.1 0.24 11.6 3.1 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) TFIIA PF03153.11 T022519_3 - 2.9 7.6 14.8 4.2 7.1 14.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.11 T022519_3 - 4.4 7.9 15.2 11 6.6 15.2 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ax_dynein_light PF10211.7 T008224_2 - 6.7e-53 179.3 14.3 9.1e-53 178.8 14.3 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain RIB43A PF05914.10 T008224_2 - 0.02 13.6 11.9 0.027 13.1 11.9 1.1 1 0 0 1 1 1 0 RIB43A APG6 PF04111.10 T008224_2 - 0.36 10.0 10.9 0.53 9.5 10.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Jnk-SapK_ap_N PF09744.7 T008224_2 - 0.55 10.3 14.4 0.84 9.7 14.4 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 IncA PF04156.12 T008224_2 - 0.96 9.1 8.0 1.5 8.4 8.0 1.2 1 0 0 1 1 1 0 IncA protein DUF3373 PF11853.6 T008224_2 - 1.4 7.4 3.0 1.9 7.0 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) PRKG1_interact PF15898.3 T008224_2 - 3.7 8.4 16.0 7.4 7.4 16.0 1.5 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Mnd1 PF03962.13 T008224_2 - 5.5 6.7 14.6 8.3 6.1 14.6 1.1 1 0 0 1 1 1 0 Mnd1 family ADIP PF11559.6 T008224_2 - 5.8 6.8 15.1 9.5 6.2 15.1 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Vezatin PF12632.5 T084367_1 - 1.1e-94 316.8 3.2 1.1e-94 316.8 3.2 2.2 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes ATPase_2 PF01637.16 T084367_1 - 0.045 13.5 0.1 0.045 13.5 0.1 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea GPS2_interact PF15784.3 T088623_1 - 2.6e-38 130.5 7.2 2.6e-38 130.5 7.2 4.2 2 1 0 2 2 2 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 T088623_1 - 9.9e-19 67.1 0.5 2.4e-11 43.5 0.2 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T088623_1 - 0.00023 21.2 5.8 0.016 15.3 0.5 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 T088623_1 - 0.036 13.8 19.8 0.81 9.5 3.3 2.9 2 0 0 2 2 2 0 Myb DNA-binding like DUF4518 PF15008.4 T088623_1 - 5 6.1 13.5 0.55 9.2 7.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) TAF1D PF15333.4 T088623_2 - 1.2 8.7 7.7 2.3 7.8 7.7 1.4 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D DOT1 PF08123.11 T165958_1 - 2.3e-82 275.4 0.0 3.4e-82 274.8 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 MCC-bdg_PDZ PF10506.7 T287413_1 - 1.7e-41 139.9 21.2 1.5e-27 95.3 7.4 5.8 5 1 1 6 6 6 2 PDZ domain of MCC-2 bdg protein for Usher syndrome Mod_r PF07200.11 T287413_1 - 0.00076 19.5 0.2 0.00076 19.5 0.2 5.7 5 1 0 5 5 5 1 Modifier of rudimentary (Mod(r)) protein Gp-FAR-1 PF05823.10 T287413_1 - 0.4 10.9 7.9 0.79 9.9 4.7 2.8 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Spc7 PF08317.9 T287413_1 - 6.4 5.4 74.2 0.0067 15.2 3.8 5.6 4 1 0 5 5 5 0 Spc7 kinetochore protein FAD_binding_3 PF01494.17 T033955_1 - 1.5e-17 63.8 0.0 2.3e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain SE PF08491.8 T033955_1 - 0.004 16.1 0.0 0.2 10.5 0.0 2.2 2 0 0 2 2 2 2 Squalene epoxidase GCV_T PF01571.19 T242507_1 - 2.7e-37 128.4 0.0 4.3e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.9 T242507_1 - 1.1e-21 76.7 0.0 1.9e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain GCV_T PF01571.19 T242507_2 - 2.3e-38 131.9 0.0 3.2e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain RhoGAP PF00620.25 T080587_1 - 1.2e-21 77.0 0.0 2.1e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 T080587_1 - 2.7e-09 37.3 0.0 5.7e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.4 T080587_1 - 7.4e-07 28.8 0.0 1.5e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.24 T080587_1 - 1.9e-06 27.5 0.0 7.2e-06 25.7 0.0 2.0 2 0 0 2 2 2 1 WW domain SH3_1 PF00018.26 T080587_1 - 1.5e-05 24.4 0.0 2.9e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain PH_9 PF15410.4 T080587_1 - 0.058 13.6 0.0 0.095 12.9 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain GHMP_kinases_C PF08544.11 T080587_1 - 0.092 13.0 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 GHMP kinases C terminal RhoGAP PF00620.25 T080587_3 - 4e-08 33.1 0.0 6.1e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain SNARE_assoc PF09335.9 T054624_1 - 1.8e-16 60.6 2.0 1.8e-16 60.6 2.0 2.8 2 1 0 2 2 2 1 SNARE associated Golgi protein An_peroxidase PF03098.13 T151306_3 - 3e-182 606.8 0.0 3.6e-182 606.5 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase ApoO PF09769.7 T376978_2 - 1.7e-34 118.4 0.0 2.9e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 Apolipoprotein O p450 PF00067.20 T046405_3 - 9.1e-153 509.2 0.2 1.1e-152 508.9 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 HEAT_2 PF13646.4 T166294_1 - 2.4e-29 101.4 14.3 3.4e-13 49.7 0.1 3.2 2 2 2 4 4 4 4 HEAT repeats HEAT_PBS PF03130.14 T166294_1 - 1.9e-18 65.1 23.0 0.0012 19.2 0.0 7.1 7 0 0 7 7 7 5 PBS lyase HEAT-like repeat HEAT PF02985.20 T166294_1 - 0.00014 21.6 5.4 0.89 9.8 0.2 4.7 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.4 T166294_1 - 0.021 15.1 4.2 0.39 11.1 1.4 3.6 2 2 2 4 4 4 0 HEAT-like repeat Arm PF00514.21 T166294_1 - 0.023 14.6 0.3 4.4 7.3 0.2 2.7 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat SIMPL PF04402.12 T306992_1 - 3.7e-09 37.2 0.5 5.3e-09 36.7 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Choline_kinase PF01633.18 T236591_1 - 4.8e-71 238.6 0.0 6.4e-71 238.2 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.21 T236591_1 - 8.7e-10 38.8 3.0 9.7e-10 38.6 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.18 T236591_1 - 0.0014 17.8 0.0 0.0027 16.9 0.0 1.3 1 1 0 1 1 1 1 Ecdysteroid kinase Carn_acyltransf PF00755.18 T236591_2 - 2.9e-193 643.6 0.0 3.4e-193 643.3 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 T236591_2 - 3.7e-26 90.7 0.1 7.2e-26 89.8 0.1 1.5 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus 7tm_2 PF00002.22 T372061_2 - 3.4e-56 190.1 22.8 5.2e-56 189.6 22.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 T372061_2 - 8.6e-13 48.6 2.1 4.4e-12 46.3 2.1 2.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Glyco_hydro_15 PF00723.19 T372061_3 - 5.9e-195 648.2 0.0 7.2e-195 647.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CGI-121 PF08617.8 T191894_1 - 5.3e-37 127.3 0.1 7.8e-37 126.8 0.1 1.3 1 0 0 1 1 1 1 Kinase binding protein CGI-121 DSPc PF00782.18 T191894_1 - 3.6e-13 49.3 0.0 7.5e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 T191894_1 - 0.052 13.0 0.0 0.086 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase KRAB PF01352.25 T173335_1 - 4.1e-23 80.7 0.3 7.9e-23 79.7 0.3 1.5 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 T173335_3 - 1.6e-73 239.9 85.0 1.1e-08 35.0 0.6 14.8 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 T173335_3 - 2e-41 138.0 100.0 3.2e-05 24.0 0.3 13.6 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T173335_3 - 5e-23 79.7 90.8 0.047 14.4 0.3 13.6 13 0 0 13 13 13 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T173335_3 - 5.3e-15 54.8 74.9 0.0012 18.7 0.5 13.0 13 0 0 13 13 13 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T173335_3 - 0.00011 22.2 48.2 0.069 13.2 3.2 7.8 2 2 7 9 9 9 6 Zinc ribbon domain FYVE PF01363.19 T173335_3 - 0.081 12.9 52.8 0.018 15.1 3.1 5.3 2 2 2 4 4 4 0 FYVE zinc finger XPA_N PF01286.16 T173335_3 - 3.3 7.7 42.9 15 5.6 0.0 10.2 11 0 0 11 11 11 0 XPA protein N-terminal zf-C2H2_jaz PF12171.6 T173335_3 - 5.2 7.4 60.2 0.6 10.3 0.4 10.4 13 0 0 13 13 13 0 Zinc-finger double-stranded RNA-binding FYVE_2 PF02318.14 T066993_2 - 0.0027 17.8 0.5 0.0054 16.8 0.5 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger EpoR_lig-bind PF09067.8 T009399_3 - 1.2e-34 118.5 3.4 3.1e-31 107.5 0.1 2.5 2 0 0 2 2 2 2 Erythropoietin receptor, ligand binding fn3 PF00041.19 T009399_3 - 3.6e-11 43.1 0.0 5.1e-05 23.4 0.1 3.3 3 0 0 3 3 3 2 Fibronectin type III domain IL6Ra-bind PF09240.8 T009399_3 - 1.3e-07 31.9 4.2 0.00088 19.5 0.1 2.5 2 0 0 2 2 2 2 Interleukin-6 receptor alpha chain, binding Tmp39 PF10271.7 T007194_1 - 1.7e-203 676.4 20.9 2.2e-203 675.9 20.9 1.2 1 0 0 1 1 1 1 Putative transmembrane protein Qua1 PF16274.3 T007194_1 - 3.4e-32 110.1 2.6 6.3e-32 109.2 2.6 1.5 1 0 0 1 1 1 1 Qua1 domain Sam68-YY PF16568.3 T007194_1 - 3.4e-14 53.2 36.5 5.6e-14 52.5 36.5 1.4 1 0 0 1 1 1 1 Tyrosine-rich domain of Sam68 KH_1 PF00013.27 T007194_1 - 5e-10 38.9 0.0 8.8e-10 38.1 0.0 1.4 1 0 0 1 1 1 1 KH domain Plant_zn_clust PF10533.7 T007194_3 - 1.2 8.9 4.6 5.4 6.9 0.7 2.8 2 0 0 2 2 2 0 Plant zinc cluster domain Filament PF00038.19 T022339_2 - 3.8e-97 325.5 55.0 5e-97 325.1 55.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.17 T022339_2 - 2.2e-17 63.3 0.0 3.9e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Lamin Tail Domain Fez1 PF06818.13 T022339_2 - 0.0031 17.9 25.2 0.0031 17.9 25.2 3.1 1 1 1 3 3 3 1 Fez1 Reo_sigmaC PF04582.10 T022339_2 - 0.0086 15.4 14.1 0.031 13.5 0.5 3.1 1 1 2 3 3 3 3 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.10 T022339_2 - 0.015 15.3 58.8 0.31 11.0 25.4 4.0 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein IncA PF04156.12 T022339_2 - 0.036 13.7 67.0 0.26 10.9 22.0 3.8 1 1 2 3 3 3 0 IncA protein CENP-F_leu_zip PF10473.7 T022339_2 - 0.41 10.5 54.1 1.1 9.2 10.9 3.4 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tht1 PF04163.10 T022339_2 - 0.69 8.5 7.7 1 7.9 7.7 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein Spc7 PF08317.9 T022339_2 - 4.2 6.0 51.8 2.8 6.6 8.8 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein ATG16 PF08614.9 T022339_2 - 9.7 6.2 72.0 0.011 15.7 24.4 3.8 2 2 2 4 4 4 0 Autophagy protein 16 (ATG16) DUF4113 PF13438.4 T022339_3 - 0.48 10.4 4.2 0.38 10.7 0.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4113) Collagen PF01391.16 T365259_1 - 8.8e-138 448.0 548.0 5.3e-10 38.8 31.1 20.4 4 2 11 15 15 15 11 Collagen triple helix repeat (20 copies) COLFI PF01410.16 T365259_1 - 7e-52 175.9 0.2 3.7e-25 88.4 0.2 2.1 1 1 1 2 2 2 2 Fibrillar collagen C-terminal domain Laminin_G_2 PF02210.22 T365259_1 - 0.00011 22.7 0.0 0.0055 17.1 0.0 2.2 2 0 0 2 2 2 1 Laminin G domain Laminin_G_3 PF13385.4 T365259_1 - 0.077 13.0 0.0 0.45 10.5 0.0 2.0 2 0 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily Collagen PF01391.16 T365259_3 - 1.3e-07 31.2 8.8 1.3e-07 31.2 8.8 10.9 11 0 0 11 11 11 3 Collagen triple helix repeat (20 copies) Ocnus PF05005.13 T369516_2 - 7.9e-39 132.0 0.2 1.1e-38 131.4 0.2 1.2 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) TMEM141 PF15110.4 T369516_2 - 2.3e-18 66.4 0.0 4e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 TMEM141 protein family MAM PF00629.21 T369516_3 - 2.2e-191 628.8 0.0 9e-38 129.5 0.1 6.3 6 0 0 6 6 6 6 MAM domain, meprin/A5/mu Ras PF00071.20 T369516_3 - 3.1e-09 36.5 0.0 0.00062 19.3 0.1 2.2 2 0 0 2 2 2 2 Ras family Ldl_recept_a PF00057.16 T369516_3 - 1e-06 28.7 42.0 2e-06 27.7 7.5 3.6 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A Roc PF08477.11 T369516_3 - 5.6e-06 26.5 0.4 5.6e-05 23.2 0.2 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T369516_3 - 0.0046 16.3 0.0 0.0089 15.4 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family eIF3_subunit PF08597.8 T369516_3 - 0.22 11.3 17.9 0.43 10.3 17.9 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit RNA_polI_A34 PF08208.9 T369516_3 - 1.7 8.6 24.2 3.9 7.4 24.2 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.10 T369516_3 - 2.5 7.7 9.7 4.3 7.0 9.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.12 T369516_3 - 4.7 5.3 11.7 6.8 4.7 11.7 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.12 T369516_3 - 6.9 7.0 10.2 21 5.4 10.2 1.8 1 0 0 1 1 1 0 RNA polymerase III RPC4 PH PF00169.27 T074869_2 - 2.9e-18 66.2 0.4 1.8e-17 63.6 0.1 2.5 2 0 0 2 2 2 1 PH domain WW PF00397.24 T074869_2 - 1.3e-14 53.6 4.6 5.2e-07 29.4 0.3 3.5 3 0 0 3 3 3 2 WW domain zf-H2C2_2 PF13465.4 T168015_1 - 5e-31 105.6 39.4 5.7e-08 32.7 2.3 7.6 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 T168015_1 - 1.4e-24 85.0 41.3 1.4e-05 25.2 0.3 7.1 7 0 0 7 7 6 5 Zinc finger, C2H2 type KRAB PF01352.25 T168015_1 - 3.3e-24 84.1 1.4 7.7e-24 83.0 1.4 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T168015_1 - 5.6e-09 36.0 32.4 0.027 15.2 0.4 6.8 6 0 0 6 6 6 4 C2H2-type zinc finger XPA_N PF01286.16 T168015_1 - 4e-05 23.4 14.0 0.46 10.4 0.2 5.1 5 0 0 5 5 5 4 XPA protein N-terminal zf-C2H2_jaz PF12171.6 T168015_1 - 0.00026 21.1 14.6 1.2 9.4 0.9 5.3 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T168015_1 - 0.0037 17.1 26.8 0.75 9.7 0.0 5.7 6 0 0 6 6 6 4 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T168015_1 - 0.0078 16.2 16.3 0.063 13.3 1.6 3.4 3 1 0 3 3 3 2 Zinc ribbon domain zf-trcl PF13451.4 T168015_1 - 0.057 13.2 17.3 2.8 7.7 0.2 5.4 5 0 0 5 5 5 0 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 T168015_1 - 0.21 12.3 15.9 0.39 11.4 1.0 3.1 1 1 2 3 3 3 0 zinc-ribbon family TF_Zn_Ribbon PF08271.10 T168015_1 - 6.9 6.1 9.2 12 5.4 0.5 3.5 3 1 0 3 3 3 0 TFIIB zinc-binding Rpr2 PF04032.14 T168015_1 - 8.7 6.6 14.6 9 6.6 4.0 3.1 1 1 2 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF1725 PF08333.9 T168015_2 - 5.5e-07 28.9 1.3 1.1e-06 27.9 1.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T267499_3 - 8.6e-141 468.9 26.0 8.6e-141 468.9 26.0 2.7 2 1 0 2 2 2 1 L1 transposable element Exo_endo_phos PF03372.21 T267499_3 - 2.4e-09 37.3 0.0 4.4e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T267499_3 - 2.5e-07 30.4 0.9 5.2e-07 29.4 0.9 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Ribonuc_P_40 PF08584.9 T296460_1 - 1.4e-73 247.5 0.1 4.6e-45 154.0 0.0 2.2 1 1 1 2 2 2 2 Ribonuclease P 40kDa (Rpp40) subunit Pkinase PF00069.23 T211699_1 - 8e-31 107.2 0.0 1.1e-30 106.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T211699_1 - 8.4e-20 71.0 0.0 1.2e-19 70.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T211699_3 - 6.5e-30 104.2 0.0 9e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T211699_3 - 1.3e-22 80.2 0.0 2.1e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1241 PF06840.9 T211699_3 - 0.00079 19.0 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) APOBEC_N PF08210.9 T303283_1 - 1.5e-49 168.2 0.2 2.1e-49 167.7 0.2 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain TspO_MBR PF03073.13 T303283_1 - 6.3e-28 97.4 20.9 1.5e-27 96.1 20.9 1.7 1 0 0 1 1 1 1 TspO/MBR family APOBEC_C PF05240.12 T303283_1 - 4.7e-25 87.2 0.4 8.4e-25 86.4 0.4 1.4 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 T303283_1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region Homeobox PF00046.27 T249072_2 - 8.9e-17 60.5 3.0 1.8e-16 59.5 3.0 1.5 1 0 0 1 1 1 1 Homeobox domain ELMO_CED12 PF04727.11 T192937_2 - 6.5e-17 62.1 0.1 1.4e-16 61.0 0.1 1.6 1 0 0 1 1 1 1 ELMO/CED-12 family AA_permease PF00324.19 T277442_3 - 9e-58 195.9 33.0 5.9e-37 127.2 5.9 2.2 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 T277442_3 - 2.3e-46 158.5 4.0 1.6e-29 103.1 2.1 2.9 1 1 1 2 2 2 2 Solute carrier family 12 SAM_1 PF00536.28 T008290_1 - 5.2e-15 55.5 0.0 1.2e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T008290_1 - 7.2e-14 51.5 0.0 1.5e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_lbd PF01404.17 T008290_2 - 7.6e-66 221.4 0.0 1.1e-65 220.9 0.0 1.2 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain fn3 PF00041.19 T008290_2 - 3.5e-22 78.4 0.0 1.8e-10 40.9 0.1 3.0 3 0 0 3 3 3 2 Fibronectin type III domain EphA2_TM PF14575.4 T008290_2 - 1.7e-09 38.2 0.0 2.8e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Pur_ac_phosph_N PF16656.3 T008290_2 - 0.0039 17.6 0.1 0.058 13.8 0.1 2.3 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.11 T008290_2 - 0.005 16.4 1.1 0.005 16.4 1.1 2.6 3 0 0 3 3 3 1 Putative ephrin-receptor like Pkinase_Tyr PF07714.15 T008290_3 - 2.7e-72 243.1 0.0 3.7e-72 242.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T008290_3 - 1e-27 97.1 0.0 1.4e-27 96.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain zf-H2C2_2 PF13465.4 T169588_1 - 1e-64 212.1 63.7 3.2e-11 43.0 1.4 11.3 10 0 0 10 10 10 10 Zinc-finger double domain zf-C2H2 PF00096.24 T169588_1 - 8.2e-56 183.3 74.9 1.2e-06 28.5 0.5 11.3 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T169588_1 - 1.2e-32 109.5 70.6 0.0023 18.5 0.5 11.9 10 0 0 10 10 10 10 C2H2-type zinc finger KRAB PF01352.25 T169588_1 - 4.5e-22 77.3 0.4 8.5e-22 76.4 0.4 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T169588_1 - 5.1e-21 74.0 62.8 0.022 14.6 2.2 10.8 10 0 0 10 10 10 9 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T169588_1 - 5.5e-05 23.7 36.6 0.83 10.3 1.9 5.8 3 2 2 5 5 5 4 zinc-ribbon family zf-H2C2_5 PF13909.4 T169588_1 - 0.0023 17.5 0.3 0.0023 17.5 0.3 9.6 10 1 0 10 10 9 3 C2H2-type zinc-finger domain Zn-ribbon_8 PF09723.8 T169588_1 - 0.0026 17.7 49.1 0.061 13.3 0.7 7.3 3 2 6 9 9 9 4 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T169588_1 - 0.039 14.1 47.9 0.15 12.3 0.4 10.2 10 0 0 10 10 10 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.3 T169588_1 - 2.9 8.3 55.9 0.056 13.8 1.6 9.4 1 1 8 9 9 9 0 C2HE / C2H2 / C2HC zinc-binding finger XPA_N PF01286.16 T169588_1 - 3.3 7.7 33.6 14 5.7 0.0 9.4 9 0 0 9 9 9 0 XPA protein N-terminal KRAB PF01352.25 T169588_3 - 2.5e-12 46.1 0.0 4.2e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 KRAB box TGF_beta PF00019.18 T374789_1 - 3.4e-27 95.3 0.6 4.8e-27 94.8 0.1 1.6 2 0 0 2 2 2 1 Transforming growth factor beta like domain Glycos_transf_2 PF00535.24 T032603_3 - 2.3e-28 99.0 0.0 3.3e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 T032603_3 - 2.1e-21 76.4 1.8 3.3e-21 75.7 1.8 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 T032603_3 - 0.0056 16.2 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 T032603_3 - 0.014 14.7 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 MFS_1 PF07690.14 T030170_3 - 1.3e-25 89.9 29.3 1.3e-25 89.9 29.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_transf_29 PF00777.16 T037831_1 - 4.6e-75 252.3 0.1 6.1e-75 251.9 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Pkinase_Tyr PF07714.15 T378669_2 - 1e-12 47.8 0.0 1.4e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T378669_2 - 2.4e-07 30.2 0.0 5.1e-07 29.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain HNOBA PF07701.12 T378669_2 - 0.00083 18.7 1.4 0.0013 18.1 1.4 1.2 1 0 0 1 1 1 1 Heme NO binding associated Trypsin PF00089.24 T130750_1 - 3.9e-58 196.7 0.0 1.2e-41 142.9 0.0 3.2 3 0 0 3 3 3 3 Trypsin DUF1986 PF09342.9 T130750_1 - 2e-07 31.3 0.1 0.0007 19.8 0.2 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 T130750_1 - 0.0049 17.6 0.8 0.6 10.8 0.3 3.0 2 1 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.24 T130750_3 - 9.5e-25 87.6 0.3 9.3e-15 54.9 0.7 2.4 2 0 0 2 2 2 2 Trypsin DUF1986 PF09342.9 T130750_3 - 0.00079 19.7 0.3 0.0013 19.0 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) HAP1_N PF04849.11 T126003_1 - 0.011 14.9 5.6 0.015 14.4 5.6 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Sipho_Gp157 PF05565.9 T126003_2 - 0.069 13.0 4.9 0.15 11.9 4.9 1.5 1 0 0 1 1 1 0 Siphovirus Gp157 Prominin PF05478.9 T126003_2 - 2.3 5.9 3.4 4.8 4.9 3.4 1.4 1 0 0 1 1 1 0 Prominin Reprolysin PF01421.17 T340643_3 - 5.5e-67 225.4 0.2 5.5e-67 225.4 0.2 2.2 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 T340643_3 - 3.3e-30 105.0 0.2 5.6e-30 104.3 0.2 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 T340643_3 - 3.3e-19 69.3 30.8 3.3e-19 69.3 30.8 2.6 2 0 0 2 2 2 1 Disintegrin Reprolysin_5 PF13688.4 T340643_3 - 1.9e-15 57.4 0.1 3.2e-15 56.7 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T340643_3 - 3.1e-15 56.7 0.1 5.3e-15 55.9 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T340643_3 - 1e-12 48.2 0.0 1.6e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T340643_3 - 2.3e-10 40.4 0.0 3.8e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR PF08516.10 T340643_3 - 3.6e-05 24.1 2.4 3.6e-05 24.1 2.4 3.8 4 0 0 4 4 4 2 ADAM cysteine-rich Pro_racemase PF05544.9 T105269_1 - 9.3e-08 31.4 0.0 1.3e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Proline racemase Pro_racemase PF05544.9 T105269_2 - 2.8e-98 328.8 0.2 7.8e-51 172.9 0.0 2.1 2 0 0 2 2 2 2 Proline racemase 7tm_1 PF00001.19 T105269_2 - 6.5e-39 133.7 6.6 1e-38 133.0 6.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) RhoGEF PF00621.18 T243966_2 - 2.7e-37 128.6 0.0 4.9e-37 127.8 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.4 T243966_2 - 6.8e-06 26.1 0.8 4.5e-05 23.4 0.8 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 T243966_2 - 0.0032 17.8 0.0 0.0069 16.7 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_13 PF16652.3 T243966_2 - 0.0058 16.4 0.2 0.028 14.2 0.1 2.1 2 1 0 2 2 2 1 Pleckstrin homology domain Mnd1 PF03962.13 T273050_2 - 2.4e-70 236.1 7.0 2.8e-70 235.9 7.0 1.1 1 0 0 1 1 1 1 Mnd1 family DivIC PF04977.13 T273050_2 - 0.00017 21.1 9.7 0.0016 18.0 2.2 3.2 1 1 2 3 3 3 2 Septum formation initiator Penicillinase_R PF03965.14 T273050_2 - 0.00029 21.0 0.5 0.00046 20.4 0.5 1.3 1 0 0 1 1 1 1 Penicillinase repressor TBPIP PF07106.11 T273050_2 - 0.00032 20.4 4.8 0.00049 19.8 4.8 1.2 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DsrD PF08679.9 T273050_2 - 0.031 14.4 0.1 0.069 13.3 0.1 1.5 1 0 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) TrmB PF01978.17 T273050_2 - 0.062 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Spc7 PF08317.9 T273050_2 - 0.078 11.7 11.3 0.29 9.8 11.3 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein SOGA PF11365.6 T273050_2 - 0.082 13.9 1.7 0.082 13.9 1.7 1.9 1 1 1 2 2 2 0 Protein SOGA RasGAP_C PF03836.13 T273050_2 - 0.18 11.8 3.4 0.17 11.9 1.9 1.7 1 1 1 2 2 2 0 RasGAP C-terminus DUF2959 PF11172.6 T273050_2 - 0.21 11.5 3.8 0.39 10.6 3.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) APG6 PF04111.10 T273050_2 - 0.34 10.1 7.4 0.48 9.6 7.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 T273050_2 - 0.39 10.4 9.0 0.62 9.7 9.0 1.2 1 0 0 1 1 1 0 IncA protein LPP PF04728.11 T273050_2 - 1.4 9.2 5.5 0.39 11.0 0.4 2.3 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Somatomedin_B PF01033.15 T305451_2 - 1.3e-05 25.3 23.8 1.3e-05 25.3 23.8 2.6 3 0 0 3 3 3 1 Somatomedin B domain Propeptide_C1 PF08127.11 T305451_2 - 0.053 13.3 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C1 propeptide Fanconi_C PF02106.13 T363005_3 - 2.2e-145 485.4 0.6 2.8e-145 485.1 0.6 1.1 1 0 0 1 1 1 1 Fanconi anaemia group C protein Ion_trans PF00520.29 T071548_2 - 0.012 14.7 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Ion transport protein KRAB PF01352.25 T335541_1 - 1e-28 98.6 4.2 4e-20 71.1 0.6 2.5 2 0 0 2 2 2 2 KRAB box Dimer_Tnp_hAT PF05699.12 T335541_3 - 9.2e-07 28.4 0.2 1.8e-06 27.5 0.2 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region MOR2-PAG1_N PF14222.4 T264460_1 - 4.7e-169 563.7 6.4 7.5e-169 563.0 6.4 1.3 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.4 T264460_1 - 1.5e-74 250.9 6.6 1.5e-74 250.9 6.6 2.7 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.4 T264460_1 - 1.2e-38 132.4 12.0 6.6e-16 57.2 0.2 6.1 6 0 0 6 6 6 6 Cell morphogenesis central region Glyco_hydro_38C PF07748.11 T287196_1 - 4.6e-82 276.3 0.9 5.9e-82 276.0 0.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro_38 PF01074.20 T287196_3 - 1.1e-107 359.5 1.4 1.5e-107 359.2 1.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.9 T287196_3 - 2.7e-25 88.4 0.4 4.9e-25 87.6 0.4 1.4 1 0 0 1 1 1 1 Alpha mannosidase middle domain Ras PF00071.20 T378090_3 - 1.2e-38 132.1 0.0 1.6e-38 131.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T378090_3 - 1.1e-21 77.2 0.0 1.5e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SOCS_box PF07525.14 T378090_3 - 1.5e-06 28.3 1.8 2.9e-06 27.4 1.8 1.5 1 0 0 1 1 1 1 SOCS box Arf PF00025.19 T378090_3 - 2.4e-06 27.0 0.0 3.6e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 T378090_3 - 0.02 14.9 0.0 0.029 14.3 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase CS PF04969.14 T172973_1 - 0.0017 19.2 0.1 0.0027 18.6 0.1 1.3 1 0 0 1 1 1 1 CS domain RepA1_leader PF08048.10 T172973_2 - 0.029 14.5 3.7 0.082 13.1 3.7 1.8 1 0 0 1 1 1 0 Tap RepA1 leader peptide TUDOR PF00567.22 T172973_3 - 2e-30 105.2 1.4 7e-20 71.1 1.5 2.6 2 0 0 2 2 2 2 Tudor domain DEAD PF00270.27 T172973_3 - 4.9e-06 26.3 0.0 1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T172973_3 - 0.034 14.4 0.0 0.095 12.9 0.0 1.8 1 0 0 1 1 1 0 Helicase conserved C-terminal domain MSC PF09402.8 T302036_2 - 3.2e-17 62.9 0.9 4.8e-17 62.4 0.9 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain LEM PF03020.13 T302036_2 - 3.5e-15 55.1 0.1 1.7e-14 53.0 0.1 2.1 2 0 0 2 2 2 1 LEM domain Post_transc_reg PF13797.4 T302036_2 - 0.19 11.5 0.8 0.35 10.6 0.8 1.4 1 0 0 1 1 1 0 Post-transcriptional regulator Motilin_ghrelin PF04644.10 T302036_3 - 2.6e-16 59.0 0.5 8e-16 57.4 0.5 1.8 1 0 0 1 1 1 1 Motilin/ghrelin Motilin_assoc PF04643.10 T302036_3 - 3.1e-09 36.4 0.0 5.2e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide Pkinase PF00069.23 T051264_3 - 2.7e-62 210.4 0.0 3.7e-62 210.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T051264_3 - 2.3e-33 115.5 0.8 2.7e-33 115.2 0.1 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 T051264_3 - 8.2e-10 38.3 0.0 1.1e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 T051264_3 - 0.047 13.5 0.9 0.19 11.5 0.3 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.12 T051264_3 - 0.075 12.2 0.2 0.15 11.3 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TF_AP-2 PF03299.12 T305012_1 - 2.6e-87 291.7 0.0 3.7e-87 291.3 0.0 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 Cementoin PF10511.7 T218462_2 - 2e-15 55.7 9.3 1.4e-07 30.9 0.2 3.6 1 1 1 3 3 3 3 Trappin protein transglutaminase binding domain WAP PF00095.19 T218462_2 - 9e-09 35.5 10.5 9e-09 35.5 10.5 1.9 3 0 0 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' RhoGAP PF00620.25 T320771_2 - 3.9e-49 166.2 0.0 6.7e-49 165.5 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 T320771_2 - 7.9e-16 57.6 8.7 1.9e-15 56.3 8.7 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH2 PF00017.22 T320771_2 - 5.2e-12 45.5 0.0 1.3e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 SH2 domain zf-RING-like PF08746.9 T320771_2 - 0.11 12.7 6.3 0.34 11.1 6.3 1.9 1 0 0 1 1 1 0 RING-like domain DUF4127 PF13552.4 T320771_2 - 0.19 10.2 0.1 0.28 9.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) COesterase PF00135.26 T329928_1 - 2.1e-45 155.5 0.0 2.8e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Peptidase_C78 PF07910.11 T329928_1 - 1.3e-21 76.9 0.0 2.2e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 AChE_tetra PF08674.8 T329928_1 - 6e-20 70.5 9.4 1e-19 69.8 9.4 1.4 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain COesterase PF00135.26 T329928_3 - 2.7e-118 396.0 0.0 3.3e-118 395.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 T329928_3 - 4.7e-05 23.2 0.3 8.8e-05 22.3 0.3 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold UCH PF00443.27 T067592_2 - 1.4e-51 175.3 0.7 2.2e-51 174.7 0.7 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 T067592_2 - 4.5e-14 52.7 4.0 6.4e-12 45.6 4.0 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.4 T067592_2 - 0.022 14.4 0.0 0.06 13.0 0.0 1.8 1 0 0 1 1 1 0 UBA-like domain UIM PF02809.18 T067592_2 - 0.15 11.9 0.4 0.49 10.3 0.4 2.0 1 0 0 1 1 1 0 Ubiquitin interaction motif TPR_3 PF07720.10 T067592_2 - 0.37 10.7 4.3 0.2 11.6 1.4 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4769 PF15992.3 T067592_2 - 1 9.0 8.6 0.026 14.2 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4769) UQ_con PF00179.24 T346023_2 - 6.6e-32 109.9 0.2 1e-31 109.3 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TLV_coat PF00429.17 T321066_1 - 5.4e-09 35.1 1.2 0.00015 20.5 0.0 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) TLV_coat PF00429.17 T321066_3 - 7.5e-07 28.1 9.4 5.8e-06 25.1 0.1 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) ATG16 PF08614.9 T090441_1 - 0.00041 20.5 25.0 0.00041 20.5 25.0 10.1 1 1 8 10 10 10 4 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.10 T090441_1 - 9.7 5.3 84.2 0.1 11.9 4.5 8.5 3 2 5 9 9 9 0 Reovirus sigma C capsid protein Arm PF00514.21 T201587_2 - 6.9e-44 146.5 7.3 3.8e-10 39.3 0.0 8.9 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 T201587_2 - 2.2e-06 27.8 0.1 0.019 15.2 0.0 2.8 2 0 0 2 2 2 2 HEAT repeats HEAT PF02985.20 T201587_2 - 0.0014 18.6 4.3 1.5 9.1 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.4 T201587_2 - 0.0022 18.3 0.9 3.4 8.1 0.0 4.5 4 0 0 4 4 4 1 HEAT-like repeat GCFC PF07842.10 T225182_1 - 2.7e-35 122.2 0.4 5.5e-35 121.2 0.4 1.5 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein ATG16 PF08614.9 T063546_1 - 2e-14 54.1 0.0 2.8e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Ribosomal_L37e PF01907.17 T063546_2 - 0.17 11.9 2.9 0.48 10.5 2.9 1.7 1 0 0 1 1 1 0 Ribosomal protein L37e WD40 PF00400.30 T063546_3 - 3.1e-21 75.1 12.4 7.4e-05 23.3 0.0 8.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ATG16 PF08614.9 T063546_3 - 4.8e-18 65.9 17.1 7.5e-18 65.3 17.1 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) ANAPC4_WD40 PF12894.5 T063546_3 - 0.057 13.6 0.1 29 4.9 0.0 3.6 1 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Atg14 PF10186.7 T063546_3 - 2 7.3 12.2 3.9 6.3 12.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IncA PF04156.12 T063546_3 - 6 6.5 11.9 10 5.7 11.9 1.2 1 0 0 1 1 1 0 IncA protein AAA_13 PF13166.4 T063546_3 - 7 5.0 5.6 9.4 4.6 5.6 1.1 1 0 0 1 1 1 0 AAA domain T-box PF00907.20 T151813_2 - 4.5e-81 271.3 0.1 6.5e-81 270.8 0.1 1.2 1 0 0 1 1 1 1 T-box p450 PF00067.20 T169891_3 - 5.7e-108 361.5 1.6 6.7e-77 259.0 0.0 3.8 4 0 0 4 4 4 3 Cytochrome P450 Sugar_tr PF00083.22 T002681_1 - 1.2e-11 44.0 0.2 1.8e-11 43.4 0.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Sugar_tr PF00083.22 T002681_2 - 7.1e-60 203.0 0.2 1e-59 202.5 0.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 T002681_2 - 1.6e-08 33.7 3.5 2.5e-08 33.1 3.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily zf-H2C2_2 PF13465.4 T130607_1 - 6.6e-83 269.6 115.0 9.1e-08 32.1 0.4 18.6 18 0 0 18 18 18 14 Zinc-finger double domain zf-C2H2 PF00096.24 T130607_1 - 1e-69 227.1 108.3 5.9e-05 23.2 0.4 16.8 16 0 0 16 16 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T130607_1 - 1.3e-49 162.4 115.5 0.00011 22.6 0.8 17.5 18 0 0 18 18 17 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T130607_1 - 2.9e-25 87.9 38.3 0.0051 17.0 0.0 15.1 15 0 0 15 15 15 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T130607_1 - 6e-19 67.4 91.4 0.0034 17.2 0.5 16.2 16 0 0 16 16 16 9 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T130607_1 - 9.6e-05 21.9 70.3 0.025 14.2 0.1 13.2 14 0 0 14 14 14 6 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T130607_1 - 0.00017 21.5 75.6 0.022 14.8 1.9 12.1 5 3 9 14 14 14 6 Zinc ribbon domain BDHCT_assoc PF16204.3 T130607_1 - 0.019 14.5 3.1 8.8 5.8 0.1 3.2 3 0 0 3 3 3 0 BDHCT-box associated domain on Bloom syndrome protein zf-C2HC_2 PF13913.4 T130607_1 - 0.02 14.6 1.1 0.02 14.6 1.1 12.1 13 0 0 13 13 12 0 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.3 T130607_1 - 0.049 14.2 41.6 0.69 10.6 0.2 8.0 6 3 1 8 8 8 0 zinc-ribbon family C1_4 PF07975.10 T130607_1 - 0.1 12.7 49.2 0.57 10.3 0.1 10.2 4 1 10 14 14 14 0 TFIIH C1-like domain zf-LYAR PF08790.9 T130607_1 - 0.11 12.3 45.1 2.2 8.2 0.1 11.8 14 0 0 14 14 14 0 LYAR-type C2HC zinc finger DUF3268 PF11672.6 T130607_1 - 0.31 11.3 23.0 3 8.1 0.1 6.9 7 0 0 7 7 7 0 zinc-finger-containing domain zf-AN1 PF01428.14 T130607_1 - 0.4 10.8 68.4 5.2 7.2 0.3 15.3 15 1 1 16 16 16 0 AN1-like Zinc finger HypA PF01155.17 T130607_1 - 6 6.8 47.6 8.4 6.3 3.5 8.3 2 2 4 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-met PF12874.5 T130607_1 - 8.7 6.7 88.7 0.28 11.5 0.4 15.0 17 0 0 17 17 16 0 Zinc-finger of C2H2 type Glyco_hydro_18 PF00704.26 T028292_1 - 5.2e-103 344.9 1.4 6.7e-103 344.5 1.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF4723 PF15851.3 T301115_3 - 0.016 15.2 6.7 0.037 14.0 6.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) FA_desaturase PF00487.22 T059903_2 - 5.8e-17 62.2 5.7 9.1e-17 61.6 5.7 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.26 T059903_3 - 2e-18 66.2 0.0 3.2e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.22 T059903_3 - 2.6e-11 43.7 6.1 2.6e-11 43.7 6.1 2.1 1 1 1 2 2 2 1 Fatty acid desaturase CHDCT2 PF08074.9 T141178_2 - 1.4e-90 301.9 0.9 2.9e-90 300.9 0.9 1.6 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF1086 PF06461.9 T141178_2 - 7.8e-62 207.1 0.0 2.5e-61 205.4 0.0 1.9 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.21 T141178_2 - 2.9e-61 207.0 0.0 7.2e-61 205.7 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain CHDNT PF08073.10 T141178_2 - 2.6e-26 91.2 0.4 6.2e-26 89.9 0.4 1.7 1 0 0 1 1 1 1 CHDNT (NUC034) domain DUF1087 PF06465.11 T141178_2 - 6.3e-25 86.9 6.6 6.3e-25 86.9 6.6 2.8 3 0 0 3 3 1 1 Domain of Unknown Function (DUF1087) Helicase_C PF00271.29 T141178_2 - 1.2e-21 77.0 0.0 2.3e-21 76.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 T141178_2 - 3e-20 71.7 26.4 1.7e-10 40.5 7.3 2.5 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.22 T141178_2 - 3e-19 68.5 6.8 8.8e-14 51.0 2.5 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 T141178_2 - 1.7e-08 34.5 0.0 5.1e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 T141178_2 - 4.6e-08 32.4 0.0 1.2e-07 31.0 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 HMG_box PF00505.17 T141178_2 - 0.0035 17.6 0.2 0.0035 17.6 0.2 2.3 2 0 0 2 2 1 1 HMG (high mobility group) box DEAD PF00270.27 T141178_2 - 0.0054 16.4 0.0 0.019 14.6 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase PHD_2 PF13831.4 T141178_2 - 0.048 13.1 11.5 0.28 10.6 3.1 2.7 2 0 0 2 2 2 0 PHD-finger AAA_22 PF13401.4 T141178_2 - 0.11 12.6 0.0 0.48 10.6 0.0 2.2 1 0 0 1 1 1 0 AAA domain DUF3140 PF11338.6 T141178_2 - 0.13 12.5 1.2 0.47 10.8 1.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) zf-PHD-like PF15446.4 T141178_2 - 3.7 7.0 15.9 0.97 8.9 0.7 3.1 1 1 0 2 2 2 0 PHD/FYVE-zinc-finger like domain IL8 PF00048.18 T145654_2 - 6.4e-22 77.3 2.9 9.9e-22 76.7 2.9 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like PX PF00787.22 T288155_1 - 4.1e-14 52.4 0.6 8.4e-14 51.4 0.6 1.5 1 0 0 1 1 1 1 PX domain DUF1725 PF08333.9 T293901_3 - 1.2e-07 31.0 1.0 2.2e-07 30.2 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Glyco_hydro_56 PF01630.16 T332368_2 - 8.6e-136 452.2 0.0 1.1e-135 451.9 0.0 1.1 1 0 0 1 1 1 1 Hyaluronidase DUF2180 PF09947.7 T332368_2 - 0.066 13.1 0.2 0.15 11.9 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) AROS PF15684.3 T234038_2 - 1.1e-36 126.1 8.0 1.7e-36 125.5 8.0 1.2 1 0 0 1 1 1 1 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 DUF3534 PF12053.6 T039809_2 - 7.3e-58 194.8 1.8 8.7e-58 194.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3534) PDZ PF00595.22 T039809_2 - 1.3e-37 127.9 5.5 3.9e-16 59.0 0.2 3.5 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T039809_2 - 1.9e-14 53.6 0.6 8.6e-06 25.9 0.1 3.9 3 1 1 4 4 4 3 PDZ domain TPR_11 PF13414.4 T039809_2 - 0.14 11.7 0.1 0.28 10.8 0.1 1.4 1 0 0 1 1 1 0 TPR repeat Ephrin_rec_like PF07699.11 T016789_3 - 2.2e-05 24.0 65.6 0.00049 19.7 4.6 7.4 4 3 3 7 7 7 7 Putative ephrin-receptor like NCD3G PF07562.12 T016789_3 - 0.00084 19.1 49.4 0.079 12.8 8.3 6.0 5 0 0 5 5 5 4 Nine Cysteines Domain of family 3 GPCR BCDHK_Adom3 PF10436.7 T328612_3 - 3.9e-50 169.7 0.2 5.5e-50 169.2 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.24 T328612_3 - 9.3e-14 51.8 0.0 1.6e-13 51.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BACK PF07707.13 T321340_2 - 3.8e-27 94.3 3.3 7.7e-27 93.3 3.3 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 T321340_2 - 1.3e-26 92.9 3.5 1.7e-26 92.5 1.3 2.0 1 1 1 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.23 T321340_2 - 2.7e-15 55.6 12.1 1.7e-08 33.8 0.1 6.0 4 3 0 4 4 4 3 Kelch motif Kelch_6 PF13964.4 T321340_2 - 2.5e-14 52.8 1.5 0.0011 19.0 0.0 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.13 T321340_2 - 5.9e-06 25.9 4.6 0.4 10.6 0.0 4.9 4 1 0 4 4 4 2 Kelch motif Kelch_4 PF13418.4 T321340_2 - 1.1e-05 25.1 0.1 0.31 10.9 0.0 3.8 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.4 T321340_2 - 0.00084 19.4 1.4 1.9 8.8 0.0 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain zf-H2C2_2 PF13465.4 T180246_1 - 7.6e-116 373.7 308.7 4.2e-07 30.0 0.6 36.1 36 1 0 36 36 36 30 Zinc-finger double domain zf-C2H2 PF00096.24 T180246_1 - 2.3e-83 270.1 302.4 6.1e-05 23.1 4.4 35.0 34 0 0 34 34 34 31 Zinc finger, C2H2 type KRAB PF01352.25 T180246_1 - 2.6e-47 158.1 2.1 3.3e-25 87.3 0.3 2.5 2 0 0 2 2 2 2 KRAB box zf-C2H2_4 PF13894.4 T180246_1 - 1.3e-21 75.2 282.7 0.087 13.6 0.2 34.4 34 0 0 34 34 34 22 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T180246_1 - 0.0027 17.5 0.4 0.0027 17.5 0.4 30.3 32 0 0 32 32 32 16 C2H2-type zinc finger BolA PF01722.16 T180246_1 - 0.078 13.1 54.3 0.4 10.9 1.1 12.2 11 3 3 14 14 14 0 BolA-like protein zf-H2C2_2 PF13465.4 T180246_2 - 1.4e-81 265.4 147.4 7.5e-09 35.5 1.1 20.5 19 1 0 19 19 19 15 Zinc-finger double domain zf-C2H2 PF00096.24 T180246_2 - 5.7e-53 174.4 168.3 4.8e-06 26.6 3.2 20.8 20 0 0 20 20 20 15 Zinc finger, C2H2 type KRAB PF01352.25 T180246_2 - 1.1e-25 88.9 0.2 2e-25 88.0 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T180246_2 - 5e-10 39.2 154.9 0.025 15.3 2.7 19.4 19 0 0 19 19 19 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T180246_2 - 1e-06 28.4 104.5 0.07 13.0 0.2 15.6 15 0 0 15 15 15 11 C2H2-type zinc finger zf-met PF12874.5 T180246_2 - 0.85 10.0 89.7 0.037 14.3 1.3 13.4 14 0 0 14 14 14 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 T180246_3 - 7.7e-124 399.0 242.1 1.3e-08 34.7 3.0 31.2 30 1 0 30 30 30 23 Zinc-finger double domain zf-C2H2 PF00096.24 T180246_3 - 2.9e-94 304.5 240.3 1.2e-05 25.3 0.8 29.2 28 0 0 28 28 28 25 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T180246_3 - 2.2e-32 108.8 222.9 0.046 14.4 0.7 28.2 27 0 0 27 27 27 21 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T180246_3 - 2.1e-13 49.8 179.6 0.024 14.5 0.3 25.6 25 0 0 25 25 25 18 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T180246_3 - 0.00073 19.1 1.4 0.00073 19.1 1.4 19.5 23 0 0 23 23 23 3 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T180246_3 - 0.034 14.1 146.1 0.04 13.9 3.1 17.7 8 7 8 19 19 19 0 Zinc ribbon domain zf-met PF12874.5 T180246_3 - 1.1 9.6 158.0 0.036 14.3 1.2 20.3 22 1 0 22 22 22 0 Zinc-finger of C2H2 type Helicase_C PF00271.29 T075071_1 - 1.6e-18 67.0 0.0 6.8e-17 61.7 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.27 T075071_1 - 8e-17 61.4 0.0 1.6e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.3 T075071_1 - 8.8e-12 45.4 5.0 8.8e-12 45.4 5.0 2.1 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.13 T075071_1 - 9.1e-07 28.9 0.7 1.9e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RQC PF09382.8 T075071_1 - 0.00019 21.0 0.0 0.00073 19.2 0.0 2.0 1 1 0 1 1 1 1 RQC domain Lipoprotein_3 PF00938.15 T075071_1 - 0.017 15.2 0.9 1.9 8.6 0.0 3.0 2 0 0 2 2 2 0 Lipoprotein SKA2 PF16740.3 T075071_1 - 0.05 13.2 3.1 0.03 14.0 0.8 1.8 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Spectrin PF00435.19 T075071_1 - 0.11 12.9 3.0 0.29 11.5 3.0 1.7 1 0 0 1 1 1 0 Spectrin repeat Snapin_Pallidin PF14712.4 T075071_1 - 0.25 11.7 5.4 0.17 12.2 2.6 2.2 2 0 0 2 2 2 0 Snapin/Pallidin Osmo_CC PF08946.8 T075071_1 - 0.46 10.7 2.9 1.6 8.9 2.9 1.9 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Med23 PF11573.6 T311364_3 - 0 2015.4 6.3 0 2015.1 6.3 1.1 1 0 0 1 1 1 1 Mediator complex subunit 23 zf-ANAPC11 PF12861.5 T156709_3 - 2e-43 146.2 19.8 3.7e-43 145.4 19.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 T156709_3 - 3.1e-20 72.0 21.5 3.1e-20 72.0 21.5 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.4 T156709_3 - 0.002 18.2 24.9 0.002 18.2 24.9 3.8 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.4 T156709_3 - 0.026 14.2 11.5 0.026 14.2 11.5 3.5 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T156709_3 - 0.63 10.0 14.8 4.6 7.2 14.2 2.5 1 1 1 2 2 2 0 RING-type zinc-finger Septin PF00735.16 T379355_2 - 9.1e-95 317.0 0.6 1.5e-94 316.3 0.6 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 T379355_2 - 0.0002 21.3 0.0 0.00037 20.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 T379355_2 - 0.0062 16.7 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Roc PF08477.11 T379355_2 - 0.015 15.4 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 T379355_2 - 0.021 15.1 0.3 0.05 13.8 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain Atg14 PF10186.7 T379355_2 - 0.061 12.3 11.0 0.1 11.6 11.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_29 PF13555.4 T379355_2 - 0.079 12.6 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IMD PF08397.9 T379355_2 - 0.1 11.8 11.7 0.18 11.1 11.7 1.2 1 0 0 1 1 1 0 IRSp53/MIM homology domain AAA_23 PF13476.4 T379355_2 - 0.12 12.8 13.9 13 6.1 12.2 2.4 2 0 0 2 2 2 0 AAA domain DUF2959 PF11172.6 T379355_2 - 0.12 12.2 6.6 0.19 11.6 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) GTP_EFTU PF00009.25 T379355_2 - 0.17 11.3 3.4 5.6 6.3 0.0 2.7 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Fzo_mitofusin PF04799.11 T379355_2 - 0.31 10.4 8.2 0.59 9.5 8.2 1.3 1 0 0 1 1 1 0 fzo-like conserved region TPR_MLP1_2 PF07926.10 T379355_2 - 1.6 8.7 17.0 2.7 7.9 17.0 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Dynamin_N PF00350.21 T379355_2 - 2.3 8.1 4.7 16 5.4 0.0 2.2 2 0 0 2 2 2 0 Dynamin family Exonuc_VII_L PF02601.13 T379355_2 - 3.4 7.0 8.5 5.5 6.3 8.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF87 PF01935.15 T379355_2 - 4 7.3 5.6 10 5.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF87 APG6 PF04111.10 T379355_2 - 9.4 5.4 14.1 15 4.7 14.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-H2C2_2 PF13465.4 T182203_1 - 1.2e-108 350.9 164.3 1.1e-07 31.8 0.1 22.3 21 2 1 22 22 22 17 Zinc-finger double domain zf-C2H2 PF00096.24 T182203_1 - 6e-70 227.9 140.0 4.8e-06 26.6 0.3 19.0 18 0 0 18 18 18 15 Zinc finger, C2H2 type KRAB PF01352.25 T182203_1 - 6.6e-38 128.0 7.0 8.1e-19 66.9 0.7 2.5 2 0 0 2 2 2 2 KRAB box zf-C2H2_4 PF13894.4 T182203_1 - 1.6e-29 99.9 146.3 0.013 16.2 0.3 20.2 19 0 0 19 19 19 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T182203_1 - 4.9e-07 29.4 115.3 0.03 14.2 0.4 17.2 17 0 0 17 17 17 9 C2H2-type zinc finger Hyphal_reg_CWP PF11765.6 T182203_1 - 0.00068 18.5 0.8 0.0012 17.8 0.8 1.3 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal zf-C2H2_jaz PF12171.6 T182203_1 - 0.069 13.3 64.6 3.2 8.0 0.1 14.3 16 0 0 16 16 16 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T182203_1 - 1.2 9.1 100.2 0.64 10.1 3.6 10.9 8 2 4 12 12 12 0 Zinc ribbon domain zf-met PF12874.5 T182203_1 - 2.7 8.4 79.5 0.022 15.0 1.0 12.6 12 0 0 12 12 12 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 T182203_1 - 5.2 6.8 79.9 1.2 8.8 0.5 14.4 14 0 0 14 14 14 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.4 T182203_2 - 1.7e-90 293.6 98.6 1.3e-08 34.8 0.5 17.7 17 0 0 17 17 17 14 Zinc-finger double domain zf-C2H2 PF00096.24 T182203_2 - 3.3e-61 200.3 140.4 2.7e-06 27.4 0.8 17.5 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T182203_2 - 5.2e-24 82.7 136.9 0.0091 16.6 2.5 18.1 17 0 0 17 17 17 15 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T182203_2 - 5.7e-13 48.3 106.3 0.072 12.9 0.8 16.2 15 0 0 15 15 15 13 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T182203_3 - 1.2e-67 221.3 83.1 1.2e-07 31.7 0.6 15.2 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2 PF00096.24 T182203_3 - 3.7e-38 127.7 132.0 2.3e-05 24.4 0.2 16.2 16 0 0 16 16 16 11 Zinc finger, C2H2 type KRAB PF01352.25 T182203_3 - 2e-21 75.2 0.2 3.7e-21 74.4 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T182203_3 - 9.6e-07 29.0 155.4 0.026 15.2 0.3 17.6 19 0 0 19 19 19 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T182203_3 - 2.5e-06 27.2 85.9 0.025 14.4 1.4 12.5 12 0 0 12 12 12 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T182203_3 - 1.4 9.0 62.6 0.93 9.5 3.7 7.9 5 2 2 8 8 8 0 Zinc ribbon domain NAD_synthase PF02540.15 T063165_1 - 4.7e-27 94.5 0.0 1.4e-26 93.0 0.0 1.7 1 1 0 1 1 1 1 NAD synthase JIP_LZII PF16471.3 T150650_3 - 8.3e-29 99.4 12.7 8.3e-29 99.4 12.7 3.2 4 0 0 4 4 4 1 JNK-interacting protein leucine zipper II RILP PF11461.6 T150650_3 - 0.63 10.2 7.4 0.072 13.2 0.4 2.6 2 0 0 2 2 2 0 Rab interacting lysosomal protein RNA_lig_T4_1 PF09511.8 T093543_2 - 0.081 12.6 1.0 0.23 11.2 1.0 1.7 1 0 0 1 1 1 0 RNA ligase TNFR_c6 PF00020.16 T002505_2 - 8.8e-05 22.7 9.2 8.8e-05 22.7 9.2 5.4 3 1 1 4 4 4 3 TNFR/NGFR cysteine-rich region MMR_HSR1 PF01926.21 T375175_3 - 4.9e-14 52.3 0.0 2.5e-12 46.7 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.16 T375175_3 - 1.2e-07 31.3 0.2 5.5e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.14 T375175_3 - 0.00075 19.3 0.2 0.98 9.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 T375175_3 - 0.0076 15.7 0.2 0.06 12.7 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain PDZ PF00595.22 T120674_3 - 6.3e-49 164.1 1.5 5.1e-17 61.9 0.1 4.3 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T120674_3 - 4.9e-14 52.3 0.0 0.028 14.6 0.0 4.5 4 0 0 4 4 4 4 PDZ domain WD40 PF00400.30 T145753_2 - 1.2e-55 184.0 19.7 2e-07 31.5 0.2 9.3 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T145753_2 - 1.5e-16 60.3 3.1 3.2e-05 24.0 0.1 4.9 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.10 T145753_2 - 0.0088 15.8 0.5 1.4 8.8 0.1 3.3 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat eIF2A PF08662.9 T145753_2 - 0.02 14.6 0.0 1.2 8.8 0.0 2.8 2 2 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 T145753_2 - 0.08 11.4 2.4 25 3.2 0.1 3.8 3 2 2 5 5 5 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 T145753_2 - 0.12 11.1 0.0 7.4 5.3 0.0 3.0 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.9 T145753_2 - 0.17 10.4 0.1 4.3 5.9 0.0 2.3 2 0 0 2 2 2 0 Nup133 N terminal like NLE PF08154.10 T145753_3 - 9.1e-11 42.0 0.0 1.7e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain 7tm_1 PF00001.19 T007072_1 - 6e-55 186.2 8.8 7.9e-55 185.8 8.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T007072_1 - 0.02 14.1 8.1 0.069 12.4 8.1 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 T007072_1 - 0.12 11.9 9.3 0.016 14.8 4.8 1.6 2 0 0 2 2 2 0 Olfactory receptor TPPK_C PF12555.6 T007072_1 - 0.25 11.3 5.1 3.2 7.8 0.5 2.6 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal NADH_dh_m_C1 PF15088.4 T271891_2 - 2.8e-32 110.0 0.2 4e-32 109.4 0.2 1.2 1 0 0 1 1 1 1 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial SNF2_N PF00176.21 T122452_2 - 1e-66 225.0 0.5 1.5e-66 224.3 0.5 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.22 T122452_2 - 3.2e-35 119.7 7.0 7.4e-23 80.1 0.0 3.9 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.4 T122452_2 - 2.3e-25 88.8 1.1 8.9e-25 86.9 1.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) Helicase_C PF00271.29 T122452_2 - 2.2e-19 69.8 0.0 4.2e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 T122452_2 - 4.1e-08 33.3 0.0 4.1e-08 33.3 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.9 T122452_2 - 0.015 15.3 0.0 0.14 12.2 0.0 2.3 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain Y_phosphatase PF00102.25 T027983_1 - 1.8e-76 256.7 0.0 2.4e-76 256.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 T027983_1 - 0.008 15.9 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 T027983_1 - 0.04 13.7 0.0 0.063 13.1 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family Arf PF00025.19 T027983_2 - 2.4e-44 150.7 0.1 3.5e-44 150.2 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 T027983_2 - 3.3e-16 59.2 0.0 4.3e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T027983_2 - 8.6e-15 54.9 0.0 1.3e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.10 T027983_2 - 1.4e-07 31.0 0.0 1.9e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 T027983_2 - 2.8e-06 26.7 0.0 4.1e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 T027983_2 - 9.7e-05 21.5 0.1 0.0035 16.4 0.0 2.1 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.21 T027983_2 - 0.00049 20.0 0.0 0.00084 19.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Forkhead PF00250.16 T086076_2 - 6.2e-27 93.6 0.0 1e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain RNase_H PF00075.22 T073708_1 - 5.1e-17 62.3 0.0 7.7e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T073708_1 - 1.1e-05 24.9 0.1 2.4e-05 23.8 0.1 1.5 1 1 0 1 1 1 1 Gag P30 core shell protein Lectin_C PF00059.19 T073708_3 - 1.9e-07 31.7 0.3 3.9e-07 30.6 0.3 1.5 1 0 0 1 1 1 1 Lectin C-type domain Acetyltransf_1 PF00583.23 T191845_1 - 2.8e-17 62.9 0.0 4.7e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 T191845_1 - 6.5e-14 51.8 0.0 1.1e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 T191845_1 - 2e-13 50.4 0.0 3.5e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.4 T191845_1 - 1.4e-06 28.2 0.0 2.8e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.5 T191845_1 - 1.8e-05 24.7 0.0 3.9e-05 23.6 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.5 T191845_1 - 2.1e-05 24.7 0.0 3.4e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.5 T191845_1 - 0.00031 21.3 0.0 0.0005 20.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 T191845_1 - 0.00065 19.5 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Vasohibin PF14822.4 T030186_3 - 3.8e-121 402.8 0.2 5e-121 402.4 0.2 1.1 1 0 0 1 1 1 1 Vasohibin wnt PF00110.17 T047191_3 - 1.8e-64 218.1 15.0 2.4e-64 217.6 15.0 1.1 1 0 0 1 1 1 1 wnt family Forkhead PF00250.16 T103120_3 - 5.5e-36 122.6 0.3 9.4e-36 121.9 0.3 1.4 1 0 0 1 1 1 1 Forkhead domain HNF_C PF09354.8 T103120_3 - 5.9e-27 94.4 3.0 5.9e-27 94.4 3.0 2.5 2 0 0 2 2 2 1 HNF3 C-terminal domain Forkhead_N PF08430.10 T103120_3 - 4.2e-25 88.8 37.8 1.1e-24 87.4 37.8 1.7 1 0 0 1 1 1 1 Forkhead N-terminal region Ras PF00071.20 T238968_3 - 1.8e-61 206.3 0.3 2.4e-61 205.9 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T238968_3 - 6.7e-34 116.6 0.0 1.1e-33 115.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T238968_3 - 2.8e-11 43.0 0.0 4.1e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 T238968_3 - 0.00076 18.8 0.0 0.001 18.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 T238968_3 - 0.0011 18.9 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 T238968_3 - 0.05 13.4 0.8 2.4 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 RRM_1 PF00076.20 T166779_1 - 9.4e-14 50.9 0.0 2e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.25 T166779_1 - 4.2e-10 39.0 1.5 8.2e-10 38.1 1.5 1.5 1 0 0 1 1 1 1 SAP domain RRM_5 PF13893.4 T166779_1 - 1.9e-05 24.2 0.0 3.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 7tm_1 PF00001.19 T221652_1 - 1e-61 208.4 0.0 1.3e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T221652_1 - 1.7e-05 24.2 7.6 0.0015 17.9 2.2 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 T221652_1 - 0.0045 16.6 2.0 0.0071 16.0 1.2 1.6 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 T221652_1 - 0.055 12.6 12.4 0.0067 15.6 7.6 1.9 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF621 PF04789.13 T221652_1 - 0.87 8.5 7.0 1.3 7.9 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF621) EphA2_TM PF14575.4 T133937_1 - 0.018 15.7 0.2 0.039 14.6 0.2 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Spem1 PF15670.3 T133937_1 - 0.026 14.0 0.7 0.042 13.3 0.7 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 Myc_target_1 PF15179.4 T133937_1 - 0.066 13.0 0.2 0.16 11.7 0.2 1.6 1 0 0 1 1 1 0 Myc target protein 1 DUF4834 PF16118.3 T133937_1 - 0.091 13.6 0.0 0.21 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) zf-C2H2_4 PF13894.4 T125248_1 - 0.034 14.8 0.2 0.034 14.8 0.2 6.6 7 0 0 7 7 7 0 C2H2-type zinc finger KH_1 PF00013.27 T079301_1 - 1.1e-46 156.3 15.8 5e-17 61.3 0.8 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 T079301_1 - 4.9e-12 45.4 5.4 0.00067 19.3 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 T079301_1 - 0.00052 19.7 3.8 1.1 9.1 0.3 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 T079301_1 - 0.043 13.8 6.8 3.9 7.5 0.1 3.2 3 0 0 3 3 3 0 NusA-like KH domain PAX PF00292.16 T358147_1 - 6e-73 242.6 0.7 9.5e-73 241.9 0.7 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 T358147_1 - 1.4e-49 166.8 14.4 1.4e-49 166.8 14.4 1.9 2 0 0 2 2 2 1 Paired-box protein 2 C terminal HTH_32 PF13565.4 T358147_1 - 0.00071 20.0 1.2 0.06 13.9 0.0 3.4 2 1 1 3 3 3 2 Homeodomain-like domain HTH_23 PF13384.4 T358147_1 - 0.0017 18.0 0.0 0.004 16.8 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain DUF4392 PF14336.4 T108912_1 - 3.7e-10 39.5 0.0 5.3e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF4392 PF14336.4 T108912_3 - 3.7e-104 348.1 0.0 5.1e-104 347.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF1445 PF07286.10 T108912_3 - 1.5e-31 109.1 0.0 4.7e-31 107.5 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1445) SSF PF00474.15 T170509_1 - 4.9e-09 35.4 7.6 6.5e-09 35.0 7.6 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family Nramp PF01566.16 T170509_1 - 9.6 4.9 11.1 1.3 7.8 7.0 1.5 2 0 0 2 2 2 0 Natural resistance-associated macrophage protein SSF PF00474.15 T170509_2 - 7.7e-08 31.5 1.6 1.1e-07 31.0 1.6 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family Ank_2 PF12796.5 T370293_1 - 8.5e-46 154.3 3.0 1e-15 57.9 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T370293_1 - 6.8e-41 138.0 6.6 2.1e-12 47.1 0.0 5.5 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 T370293_1 - 3.2e-33 109.9 5.1 2.1e-05 24.4 0.0 8.5 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.4 T370293_1 - 1.3e-32 111.2 7.2 3.1e-10 40.0 0.0 6.3 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.28 T370293_1 - 5.1e-32 108.8 3.4 4.7e-05 23.5 0.0 7.7 7 0 0 7 7 7 6 Ankyrin repeat SET PF00856.26 T370293_1 - 1.9e-22 80.3 0.0 1.9e-22 80.3 0.0 3.5 3 1 0 3 3 3 1 SET domain Pre-SET PF05033.14 T370293_1 - 6.3e-16 58.8 13.7 6.3e-16 58.8 13.7 3.2 3 0 0 3 3 3 1 Pre-SET motif zf-C6H2 PF15801.3 T162226_3 - 0.002 18.3 3.9 0.011 15.9 3.9 2.3 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding Band_7 PF01145.23 T300601_2 - 1.5e-22 80.4 0.1 1.5e-22 80.4 0.1 2.8 2 1 1 3 3 3 1 SPFH domain / Band 7 family Flot PF15975.3 T300601_2 - 5.5e-07 29.7 8.9 5.5e-07 29.7 8.9 3.8 2 2 2 4 4 4 2 Flotillin Connexin PF00029.17 T376091_1 - 2e-82 276.2 7.7 2.8e-82 275.7 7.7 1.2 1 0 0 1 1 1 1 Connexin Peptidase_C69 PF03577.13 T203215_3 - 1.5e-09 37.3 0.1 2.2e-09 36.8 0.1 1.1 1 0 0 1 1 1 1 Peptidase family C69 AAT PF03417.14 T203215_3 - 0.011 15.3 0.0 0.031 13.8 0.0 1.7 2 0 0 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase DUF4619 PF15398.4 T105033_1 - 4.3e-53 180.6 0.1 5.5e-53 180.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4619) DUF4619 PF15398.4 T105033_2 - 3.8e-99 331.8 10.7 5e-99 331.4 10.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4619) Bromo_TP PF07524.11 T303629_2 - 7.8e-29 99.4 0.2 1.4e-28 98.5 0.2 1.5 1 0 0 1 1 1 1 Bromodomain associated TAF8_C PF10406.7 T303629_2 - 1.2e-21 76.8 2.5 3.3e-21 75.4 2.5 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term TFIID-31kDa PF02291.13 T303629_2 - 0.0015 18.5 0.0 0.0028 17.6 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP_like PF17027.3 T303629_2 - 0.0038 17.3 0.0 0.0064 16.5 0.0 1.3 1 0 0 1 1 1 1 Histone-fold protein MFS_1 PF07690.14 T314628_1 - 6e-25 87.8 26.0 6e-25 87.8 26.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 T314628_1 - 3.6e-23 82.0 23.3 6.1e-23 81.3 23.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter FAD_binding_1 PF00667.18 T278670_1 - 2.1e-51 174.5 0.0 3.3e-51 173.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.19 T278670_1 - 1.1e-16 61.3 0.0 2.1e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_1 PF00258.23 T278670_1 - 1e-06 28.9 0.3 1.9e-06 28.0 0.0 1.6 2 0 0 2 2 2 1 Flavodoxin Flavodoxin_1 PF00258.23 T278670_2 - 1.8e-06 28.1 0.0 2.5e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin zf-AN1 PF01428.14 T302912_1 - 2.2e-07 30.8 7.9 9.8e-07 28.7 7.9 2.2 1 0 0 1 1 1 1 AN1-like Zinc finger zf-A20 PF01754.14 T302912_1 - 1.8e-05 24.5 6.0 0.00035 20.3 6.5 2.8 2 0 0 2 2 2 1 A20-like zinc finger RNase_H PF00075.22 T378188_1 - 2e-13 50.7 0.0 3.1e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 RNase H zf-CCHC PF00098.21 T378188_3 - 0.00015 21.5 1.6 0.00036 20.3 1.6 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.4 T378188_3 - 0.074 12.6 11.1 0.26 10.9 4.4 2.9 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-B_box PF00643.22 T151529_3 - 9.8e-09 35.1 8.7 9.8e-09 35.1 8.7 1.9 2 0 0 2 2 2 1 B-box zinc finger MATH PF00917.24 T151529_3 - 1.3e-07 31.6 0.0 3.4e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 MATH domain MRFAP1 PF15155.4 T151529_3 - 0.24 11.8 3.8 0.24 11.8 1.5 2.1 2 0 0 2 2 2 0 MORF4 family-associated protein1 FUSC PF04632.10 T151529_3 - 0.28 9.5 2.7 0.56 8.6 2.7 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2203 PF09969.7 T151529_3 - 0.35 11.5 4.7 48 4.6 3.2 3.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) Baculo_PEP_C PF04513.10 T151529_3 - 2.9 7.8 8.8 1.9 8.4 2.4 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Allexi_40kDa PF05549.9 T151529_3 - 8 5.7 9.3 24 4.2 3.5 3.0 2 1 1 3 3 3 0 Allexivirus 40kDa protein MAJIN PF15077.4 T060954_2 - 3.2e-68 230.1 5.9 5.8e-37 127.7 0.9 2.1 1 1 1 2 2 2 2 Membrane-anchored junction protein Hormone_6 PF00236.16 T060954_2 - 0.0022 17.8 5.6 0.0046 16.8 5.6 1.4 1 0 0 1 1 1 1 Glycoprotein hormone Cys_knot PF00007.20 T060954_2 - 0.028 14.6 8.7 0.049 13.8 8.7 1.4 1 0 0 1 1 1 0 Cystine-knot domain LRR_8 PF13855.4 T013025_2 - 5.7e-52 173.2 74.8 1.5e-11 43.7 8.4 9.0 4 3 4 9 9 9 8 Leucine rich repeat LRR_4 PF12799.5 T013025_2 - 9.3e-39 130.5 81.8 8.2e-07 29.1 3.6 11.8 3 3 7 11 11 11 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 T013025_2 - 2.2e-06 27.2 36.7 0.0041 16.5 2.4 5.8 2 2 4 6 6 6 6 Leucine-rich repeat LRR_1 PF00560.31 T013025_2 - 1.1e-05 25.1 75.3 0.76 10.4 0.3 17.0 16 2 0 16 16 16 5 Leucine Rich Repeat LRR_5 PF13306.4 T013025_2 - 0.0017 18.2 8.2 0.012 15.4 0.9 4.0 3 1 1 4 4 4 1 Leucine rich repeats (6 copies) Lipocalin PF00061.21 T369632_3 - 5.3e-17 62.2 0.0 6.7e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family DUF4719 PF15843.3 T084573_1 - 0.51 10.3 5.2 0.8 9.6 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) WD40 PF00400.30 T084573_3 - 3e-09 37.2 8.2 1.5 9.7 0.2 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T084573_3 - 1.2e-08 35.0 0.1 0.019 15.2 0.0 3.5 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain RhoGAP PF00620.25 T382427_1 - 4.3e-43 146.6 0.0 8.8e-43 145.6 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.21 T382427_1 - 1.3e-12 47.6 0.8 1.3e-12 47.6 0.8 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.26 T382427_1 - 7.7e-12 44.5 0.0 1.7e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T382427_1 - 1.7e-11 43.7 0.0 3.4e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T382427_1 - 7.8e-10 38.2 0.0 2.6e-09 36.5 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain GlcNAc_2-epim PF07221.9 T382427_3 - 1.9e-40 139.0 0.0 2.6e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Acetyltransf_1 PF00583.23 T382427_3 - 3.9e-14 52.7 0.0 7.7e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 T382427_3 - 5.5e-09 35.9 0.0 8.9e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 T382427_3 - 3.7e-07 30.3 0.0 7.7e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 T382427_3 - 2.4e-06 27.3 0.0 4.6e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.5 T382427_3 - 0.018 15.0 0.0 0.04 13.9 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.4 T382427_3 - 0.06 13.2 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.3 T382427_3 - 0.095 12.0 0.2 0.16 11.3 0.2 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase zf-DHHC PF01529.18 T137325_1 - 2.6e-35 121.3 14.6 2.6e-35 121.3 14.6 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase F5_F8_type_C PF00754.23 T198368_1 - 1.5e-28 99.3 1.5 2.7e-28 98.5 1.5 1.4 1 0 0 1 1 1 1 F5/8 type C domain Laminin_G_2 PF02210.22 T198368_1 - 1.6e-24 86.8 0.2 2.4e-24 86.2 0.2 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 T198368_1 - 6e-15 55.5 0.0 9.7e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.22 T198368_3 - 3e-58 195.7 0.6 1.1e-21 77.6 0.1 3.2 3 0 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.21 T198368_3 - 6.8e-39 132.9 0.0 2.2e-14 53.6 0.0 3.2 3 0 0 3 3 3 3 Laminin G domain Laminin_G_3 PF13385.4 T198368_3 - 3.6e-05 23.8 0.0 0.006 16.6 0.0 3.5 4 0 0 4 4 4 1 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 T198368_3 - 0.00014 21.9 33.0 0.0042 17.2 9.7 3.2 3 0 0 3 3 3 2 EGF-like domain CEP209_CC5 PF16574.3 T083478_1 - 1.3e-51 174.0 24.7 1.3e-51 174.0 24.7 19.8 9 7 9 21 21 21 3 Coiled-coil region of centrosome protein CE290 TBPIP PF07106.11 T083478_1 - 0.0036 17.0 9.2 0.0036 17.0 9.2 25.3 5 5 17 26 26 26 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) IncA PF04156.12 T083478_2 - 3 7.5 15.1 5 6.7 15.1 1.3 1 0 0 1 1 1 0 IncA protein Yae1_N PF09811.7 T281830_1 - 0.91 9.2 3.6 1.7 8.3 3.6 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal FGF PF00167.16 T281830_2 - 2.7e-47 159.8 2.5 4.3e-47 159.2 2.5 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Yae1_N PF09811.7 T281830_2 - 0.19 11.3 7.8 0.37 10.4 7.8 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal MARVEL PF01284.21 T125235_1 - 2.9e-06 27.2 0.1 5.8e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 Membrane-associating domain MARVEL PF01284.21 T125235_2 - 1.5e-05 25.0 6.7 1.5e-05 25.0 6.7 1.5 2 0 0 2 2 2 1 Membrane-associating domain Ank_2 PF12796.5 T045838_1 - 1.9e-19 69.9 0.1 6.2e-10 39.4 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 T045838_1 - 8.6e-19 67.0 0.0 6.8e-07 29.3 0.0 3.9 3 1 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.4 T045838_1 - 1.6e-16 60.3 0.5 4.1e-06 27.1 0.1 4.5 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 T045838_1 - 1.1e-14 54.1 1.2 1.6e-08 34.5 0.1 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 T045838_1 - 9.1e-12 44.0 2.3 9.3e-05 22.4 0.1 5.0 5 0 0 5 5 5 2 Ankyrin repeat HIG_1_N PF04588.11 T148758_3 - 2.2e-14 53.3 1.0 3.7e-14 52.6 1.0 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Actin PF00022.17 T336276_1 - 3.5e-88 295.8 0.0 4.8e-86 288.8 0.0 2.1 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.11 T336276_1 - 0.00094 18.0 0.0 0.28 9.8 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Mito_fiss_reg PF05308.9 T174966_1 - 2.7 7.9 6.1 4.8 7.0 6.1 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Spectrin PF00435.19 T174966_2 - 1.7e-70 234.0 30.1 4.3e-23 81.7 5.3 4.5 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.29 T174966_2 - 9.5e-54 180.1 1.2 3.2e-26 91.5 0.0 3.2 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.8 T174966_2 - 5e-27 93.7 0.0 1.6e-26 92.0 0.0 2.0 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.30 T174966_2 - 4.2e-10 38.3 0.1 0.0012 18.1 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 T174966_2 - 5.9e-07 28.8 0.4 0.0032 17.1 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain CAMSAP_CH PF11971.6 T174966_2 - 3.3e-06 26.7 0.0 0.0001 21.9 0.0 2.6 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_7 PF13499.4 T174966_2 - 6.6e-06 26.4 0.1 2.3e-05 24.6 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 T174966_2 - 0.002 17.7 0.2 0.036 13.7 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair CH_2 PF06294.9 T174966_2 - 0.061 13.3 0.1 2.8 8.0 0.0 3.1 2 0 0 2 2 2 0 CH-like domain in sperm protein RE_SacI PF09566.8 T174966_2 - 5.7 6.5 7.1 1.7 8.3 0.9 2.7 2 1 0 2 2 2 0 SacI restriction endonuclease WD40 PF00400.30 T311897_1 - 4.2e-18 65.3 8.2 6.8e-06 26.6 0.3 6.2 5 0 0 5 5 5 4 WD domain, G-beta repeat SH3_1 PF00018.26 T311897_1 - 6.5e-16 57.5 0.2 1.6e-15 56.3 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T311897_1 - 1.7e-13 50.1 0.1 3.5e-13 49.1 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T311897_1 - 7.6e-12 44.6 0.0 1.5e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain ANAPC4_WD40 PF12894.5 T311897_1 - 1.2e-05 25.4 0.0 13 6.0 0.0 5.2 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain AAA_6 PF12774.5 T205214_2 - 1.4e-90 303.0 0.0 4e-90 301.5 0.0 1.8 2 0 0 2 2 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.5 T205214_2 - 2.5e-74 249.7 0.3 3.1e-73 246.1 0.1 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 T205214_2 - 1.5e-51 175.2 0.0 2.2e-51 174.6 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.5 T205214_2 - 8.8e-51 172.8 6.1 1.3e-50 172.3 6.1 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.13 T205214_2 - 2.1e-47 161.7 0.0 2.1e-47 161.7 0.0 1.9 3 0 0 3 3 3 1 Dynein heavy chain and region D6 of dynein motor AAA_5 PF07728.12 T205214_2 - 1.4e-17 63.8 0.0 0.00055 19.8 0.0 5.3 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA PF00004.27 T205214_2 - 0.00011 22.5 0.1 3.2 8.1 0.1 4.2 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 T205214_2 - 0.00063 19.9 0.4 1.8 8.7 0.0 3.8 4 0 0 4 4 4 1 AAA domain AAA_30 PF13604.4 T205214_2 - 0.0041 16.7 0.2 3.6 7.1 0.2 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.20 T205214_2 - 0.0062 16.8 0.2 8.7 6.7 0.0 3.1 3 0 0 3 3 3 0 RNA helicase EF-hand_6 PF13405.4 T205214_2 - 0.0094 15.7 1.9 0.025 14.4 1.9 1.7 1 0 0 1 1 1 1 EF-hand domain AAA_16 PF13191.4 T205214_2 - 0.01 16.1 0.0 17 5.6 0.0 3.3 3 0 0 3 3 3 0 AAA ATPase domain EF-hand_1 PF00036.30 T205214_2 - 0.01 15.2 1.5 0.027 13.9 1.5 1.7 1 0 0 1 1 1 0 EF hand AAA_18 PF13238.4 T205214_2 - 0.055 13.8 0.6 0.35 11.2 0.0 2.7 4 0 0 4 4 2 0 AAA domain T2SSE PF00437.18 T205214_2 - 0.14 11.1 0.8 0.57 9.1 0.0 2.4 4 0 0 4 4 4 0 Type II/IV secretion system protein EF-hand_5 PF13202.4 T205214_2 - 0.14 11.6 0.7 0.31 10.5 0.7 1.6 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.4 T205214_2 - 0.51 10.0 2.3 1.4 8.6 2.3 1.6 1 0 0 1 1 1 0 EF-hand domain pair Spc7 PF08317.9 T205214_2 - 0.63 8.7 15.7 1 8.1 5.7 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein EF-hand_7 PF13499.4 T205214_2 - 1.5 9.2 5.3 0.31 11.4 1.2 2.0 2 0 0 2 2 1 0 EF-hand domain pair Dynein_heavy PF03028.13 T205214_3 - 4.7e-226 752.2 0.0 2.6e-224 746.4 0.0 2.2 2 0 0 2 2 2 2 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.11 T205214_3 - 4.1e-120 401.4 0.5 4.1e-120 401.4 0.5 2.3 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.5 T205214_3 - 4.9e-85 284.0 0.1 6e-83 277.2 0.4 2.5 2 0 0 2 2 2 2 ATP-binding dynein motor region D5 WBS28 PF15164.4 T326386_2 - 6e-122 405.9 22.1 8.2e-122 405.5 22.1 1.1 1 0 0 1 1 1 1 Williams-Beuren syndrome chromosomal region 28 protein homologue I-set PF07679.14 T043090_1 - 9e-105 342.9 0.0 3e-20 72.0 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 T043090_1 - 3.2e-74 245.4 0.1 5.4e-14 52.4 0.0 6.0 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 T043090_1 - 4e-48 161.4 0.2 2.7e-09 36.9 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 T043090_1 - 1.5e-47 159.7 0.6 7.6e-09 35.7 0.0 6.0 6 0 0 6 6 6 5 Immunoglobulin domain V-set PF07686.15 T043090_1 - 1e-16 60.9 1.6 0.036 14.1 0.0 7.5 5 3 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 T043090_1 - 8.9e-10 38.4 1.2 0.76 9.8 0.0 5.0 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 T043090_1 - 7.2e-08 32.7 0.5 0.21 12.0 0.0 4.9 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 T043090_1 - 0.0021 17.9 0.0 19 5.2 0.0 3.6 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 T043090_1 - 0.0029 17.6 0.0 1.8 8.7 0.0 3.9 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 BiPBP_C PF06832.10 T043090_1 - 0.11 12.5 0.0 6 6.9 0.0 3.1 4 0 0 4 4 4 0 Penicillin-Binding Protein C-terminus Family ANTH PF07651.14 T307354_1 - 4e-84 281.8 0.3 5e-84 281.4 0.3 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.18 T307354_1 - 1.4e-14 54.1 0.0 2.3e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 ENTH domain VHS PF00790.17 T307354_1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 VHS domain cEGF PF12662.5 T126372_1 - 1.5 8.7 3.9 24 4.8 0.1 3.0 2 0 0 2 2 2 0 Complement Clr-like EGF-like 7tm_1 PF00001.19 T111658_1 - 1.1e-31 110.0 19.8 1.7e-31 109.3 19.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pkinase PF00069.23 T133401_1 - 1.6e-70 237.4 0.8 2.3e-70 236.8 0.8 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T133401_1 - 3.7e-20 72.2 0.1 5.9e-20 71.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 T133401_1 - 5.9e-09 36.1 4.0 2.9e-06 27.2 0.0 3.2 2 2 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.12 T133401_1 - 0.011 15.0 0.1 0.019 14.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.18 T133401_1 - 0.051 13.0 0.3 0.1 12.1 0.3 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-like PF14531.4 T133401_1 - 0.15 11.2 0.1 0.51 9.5 0.0 1.8 2 0 0 2 2 2 0 Kinase-like CHDCT2 PF08074.9 T072501_1 - 8e-87 289.7 0.4 8e-87 289.7 0.4 2.0 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain DUF1086 PF06461.9 T072501_1 - 2e-60 202.5 0.0 4e-60 201.5 0.0 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.21 T072501_1 - 1.2e-58 198.4 0.0 2.2e-58 197.5 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF1087 PF06465.11 T072501_1 - 7.7e-26 89.8 6.0 7.7e-26 89.8 6.0 2.7 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1087) CHDNT PF08073.10 T072501_1 - 2.3e-25 88.1 0.1 4.6e-25 87.2 0.1 1.5 1 0 0 1 1 1 1 CHDNT (NUC034) domain Helicase_C PF00271.29 T072501_1 - 4e-22 78.5 0.0 7.1e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 T072501_1 - 1.3e-20 72.9 27.9 5e-10 39.0 8.8 2.9 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.22 T072501_1 - 1.5e-17 63.1 5.6 8.7e-12 44.6 0.9 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 T072501_1 - 1.7e-09 37.8 0.3 4.2e-09 36.5 0.0 1.8 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit Filament PF00038.19 T072501_1 - 2.8e-08 33.6 5.3 2.8e-08 33.6 5.3 2.2 2 0 0 2 2 1 1 Intermediate filament protein HDA2-3 PF11496.6 T072501_1 - 1.9e-06 27.2 0.0 4.2e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 PHD_2 PF13831.4 T072501_1 - 0.017 14.5 11.7 0.22 11.0 2.8 2.7 2 0 0 2 2 2 0 PHD-finger HMG_box PF00505.17 T072501_1 - 0.019 15.2 0.1 0.052 13.8 0.1 1.7 1 0 0 1 1 1 0 HMG (high mobility group) box zf-PHD-like PF15446.4 T072501_1 - 0.6 9.6 10.2 1.8 8.0 0.8 2.9 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Cep57_MT_bd PF06657.11 T072501_1 - 1.3 9.4 8.8 2.5 8.5 0.1 3.3 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Methyltr_RsmB-F PF01189.15 T072501_2 - 5.2e-83 277.5 0.1 1.5e-82 276.0 0.0 1.8 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F P120R PF08062.9 T072501_2 - 2.3e-19 68.5 31.8 2.4e-07 30.6 1.1 3.9 3 0 0 3 3 3 3 P120R (NUC006) repeat Filament PF00038.19 T072501_2 - 1.9e-12 47.3 14.5 4.8e-09 36.1 6.9 2.2 2 0 0 2 2 2 2 Intermediate filament protein Methyltr_RsmF_N PF17125.3 T072501_2 - 8.8e-09 35.6 0.0 2e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.17 T072501_2 - 0.016 15.2 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.17 T072501_2 - 0.02 14.5 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.4 T072501_2 - 0.025 15.2 0.0 0.054 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain CENP-F_leu_zip PF10473.7 T072501_2 - 3.3 7.6 12.2 4.2 7.2 8.4 2.5 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spectrin PF00435.19 T313727_1 - 1e-112 369.7 468.9 1.1e-10 41.8 8.5 44.5 38 6 5 44 44 44 32 Spectrin repeat PHP PF02811.17 T313727_1 - 0.17 12.0 0.8 2.1 8.5 0.8 3.1 1 0 0 1 1 1 0 PHP domain KASH PF10541.7 T313727_2 - 4.3e-27 94.0 6.0 1.2e-26 92.6 6.0 1.8 1 0 0 1 1 1 1 Nuclear envelope localisation domain Rad17 PF03215.13 T283741_1 - 4.4e-253 840.7 0.0 5.4e-253 840.4 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_18 PF13238.4 T283741_1 - 2.8e-05 24.5 0.0 6.1e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 T283741_1 - 0.00021 21.6 0.0 0.00038 20.7 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.10 T283741_1 - 0.00074 18.7 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.27 T283741_1 - 0.0012 19.1 0.0 0.0021 18.3 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 T283741_1 - 0.0019 18.3 0.0 0.0037 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.4 T283741_1 - 0.0034 17.5 0.0 0.0057 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.25 T283741_1 - 0.0096 16.3 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_14 PF13173.4 T283741_1 - 0.085 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.18 T283741_1 - 0.093 11.6 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.4 T283741_1 - 0.095 12.9 0.1 0.17 12.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 T283741_1 - 0.13 11.9 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.4 T283741_1 - 0.15 11.6 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.4 T283741_1 - 0.2 12.0 0.2 0.36 11.1 0.2 1.4 1 0 0 1 1 1 0 AAA domain Occludin_ELL PF07303.11 T283741_3 - 5.9e-30 103.8 10.4 1.1e-29 102.9 10.4 1.5 1 0 0 1 1 1 1 Occludin homology domain MARVEL PF01284.21 T283741_3 - 6.6e-16 58.5 9.2 1.1e-15 57.7 9.2 1.4 1 0 0 1 1 1 1 Membrane-associating domain MAP17 PF15807.3 T283741_3 - 0.019 15.0 0.1 0.019 15.0 0.1 1.5 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Trypsin PF00089.24 T259864_1 - 2.7e-67 226.7 0.1 3.9e-67 226.2 0.1 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 T259864_1 - 1.5e-23 82.8 0.3 1.5e-23 82.8 0.3 2.3 3 0 0 3 3 3 1 Kringle domain fn2 PF00040.17 T259864_1 - 1.8e-16 60.0 3.8 1.8e-16 60.0 3.8 3.3 3 0 0 3 3 3 1 Fibronectin type II domain EGF PF00008.25 T259864_1 - 8.2e-11 41.9 19.6 4.6e-06 26.7 3.4 3.4 2 0 0 2 2 2 2 EGF-like domain fn1 PF00039.16 T259864_1 - 3e-05 24.0 8.0 9.3e-05 22.4 8.0 2.0 1 0 0 1 1 1 1 Fibronectin type I domain hEGF PF12661.5 T259864_1 - 5.8e-05 23.5 16.3 0.006 17.1 4.0 3.7 2 0 0 2 2 2 2 Human growth factor-like EGF DUF1986 PF09342.9 T259864_1 - 0.00042 20.5 0.0 0.0007 19.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EGF_2 PF07974.11 T259864_1 - 0.017 15.3 27.9 0.046 14.0 3.5 4.1 3 0 0 3 3 3 0 EGF-like domain RGS12_us1 PF16613.3 T259864_2 - 1.5e-58 196.2 11.4 1.5e-58 196.2 11.4 3.0 3 0 0 3 3 3 1 Unstructured region of RGS12 RGS12_usC PF16612.3 T259864_2 - 4.2e-56 189.2 15.2 4.2e-56 189.2 15.2 3.5 3 0 0 3 3 3 1 C-terminal unstructured region of RGS12 RGS12_us2 PF16611.3 T259864_2 - 4e-34 116.7 10.6 4e-34 116.7 10.6 2.1 2 0 0 2 2 2 1 Unstructured region between RBD and GoLoco RBD PF02196.13 T259864_2 - 2.2e-32 110.9 0.0 4.4e-19 68.2 0.0 2.5 2 0 0 2 2 2 2 Raf-like Ras-binding domain RGS PF00615.17 T259864_2 - 3.8e-27 94.8 2.7 5.5e-27 94.3 2.7 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain GoLoco PF02188.15 T259864_2 - 8.8e-09 34.6 0.3 1.9e-08 33.5 0.3 1.6 1 0 0 1 1 1 1 GoLoco motif TUG-UBL1 PF11470.6 T259864_2 - 0.014 15.5 0.0 0.44 10.7 0.0 2.5 2 0 0 2 2 2 0 TUG ubiquitin-like domain V-set PF07686.15 T100894_3 - 3.1e-20 72.2 0.6 4.9e-20 71.6 0.6 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T100894_3 - 1.6e-05 25.3 0.1 3e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T100894_3 - 0.00045 20.4 0.1 0.0013 18.9 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T100894_3 - 0.0093 16.0 0.1 0.027 14.5 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T100894_3 - 0.01 15.8 0.2 0.024 14.6 0.2 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain PDZ PF00595.22 T081574_2 - 1.1e-83 275.4 5.9 4.1e-13 49.4 0.0 7.3 7 0 0 7 7 7 7 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T081574_2 - 9.2e-30 102.7 2.5 0.00017 21.7 0.0 7.5 7 0 0 7 7 7 6 PDZ domain RVT_1 PF00078.25 T081574_3 - 0.00018 20.9 0.2 0.0031 16.9 0.3 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) CTNNB1_binding PF08347.9 T081574_3 - 0.16 12.0 0.9 0.26 11.3 0.9 1.2 1 0 0 1 1 1 0 N-terminal CTNNB1 binding TSP_1 PF00090.17 T368320_1 - 8.9e-24 83.3 59.9 2.6e-09 37.0 8.3 8.6 7 0 0 7 7 7 7 Thrombospondin type 1 domain Cg6151-P PF10233.7 T368320_3 - 0.0003 21.0 8.7 0.00098 19.3 1.9 2.3 1 1 1 2 2 2 2 Uncharacterized conserved protein CG6151-P HSF_DNA-bind PF00447.15 T134319_1 - 5e-23 81.4 0.2 8.1e-23 80.7 0.2 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding CARD PF00619.19 T134319_1 - 3.8e-17 62.0 0.0 6.2e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Caspase recruitment domain F-box-like PF12937.5 T134319_1 - 1.1e-09 37.9 0.1 2.7e-09 36.6 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T134319_1 - 1.2e-06 28.1 0.0 3.8e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 F-box domain Trypan_PARP PF05887.9 T134319_1 - 1.2 9.0 49.9 0.015 15.2 40.5 2.3 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) SPRY PF00622.26 T032289_1 - 4.2e-16 59.0 0.0 7.4e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-RING_UBOX PF13445.4 T032289_1 - 6.4e-13 48.3 3.8 2.7e-12 46.4 3.8 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 T032289_1 - 1.8e-12 47.0 4.0 1.8e-12 47.0 4.0 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 T032289_1 - 6e-11 41.9 4.9 1.8e-10 40.3 4.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T032289_1 - 2.4e-09 36.7 2.5 8.5e-09 35.0 2.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 T032289_1 - 9.8e-09 35.1 4.8 9.8e-09 35.1 4.8 3.4 2 0 0 2 2 2 1 B-box zinc finger zf-RING_2 PF13639.4 T032289_1 - 5.1e-06 26.5 5.7 5.1e-06 26.5 5.7 3.2 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 T032289_1 - 8.8e-05 22.3 5.8 8.8e-05 22.3 5.8 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 T032289_1 - 0.0003 20.5 4.5 0.0003 20.5 4.5 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 T032289_1 - 0.076 12.8 0.6 0.18 11.5 0.6 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.6 T032289_1 - 0.086 12.5 3.2 0.1 12.3 1.4 2.0 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.3 T032289_1 - 0.89 9.2 4.7 2.6 7.7 4.7 1.9 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.4 T032289_1 - 1 9.1 9.5 0.082 12.6 3.4 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 PRY PF13765.4 T032289_2 - 1.6e-22 78.7 0.2 1.6e-22 78.7 0.2 1.9 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 T032289_2 - 4.9e-13 49.1 0.0 8.9e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 T032289_2 - 1.2e-12 47.6 10.8 3.8e-12 46.0 10.8 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 T032289_2 - 5.4e-11 42.0 8.5 2e-10 40.2 8.5 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T032289_2 - 1.2e-09 37.9 8.2 4.4e-09 36.1 8.2 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 T032289_2 - 5.3e-09 35.6 10.2 1.9e-08 33.9 10.2 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T032289_2 - 9.1e-07 28.5 7.6 4.7e-06 26.2 7.6 2.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 T032289_2 - 1.7e-06 27.9 0.0 1.7e-06 27.9 0.0 3.0 3 0 0 3 3 2 1 B-box zinc finger zf-RING_2 PF13639.4 T032289_2 - 4.3e-06 26.7 10.4 4.3e-06 26.7 10.4 2.9 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 T032289_2 - 6e-05 22.8 9.0 0.00024 20.9 9.0 2.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.4 T032289_2 - 0.002 17.8 2.2 0.005 16.6 2.2 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 T032289_2 - 0.092 12.8 4.5 0.25 11.4 4.5 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 T032289_2 - 0.16 11.7 10.8 0.078 12.7 7.7 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 ATP12 PF07542.9 T143135_2 - 4.5e-39 133.3 0.3 6.8e-39 132.8 0.3 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein WD40 PF00400.30 T204581_3 - 4.9e-18 65.0 13.9 9.2e-07 29.3 0.1 7.4 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T204581_3 - 2.8e-05 24.2 0.1 19 5.5 0.0 5.0 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain TSNAXIP1_N PF15739.3 T189596_2 - 8.2e-17 61.5 0.5 8.2e-17 61.5 0.5 2.1 3 0 0 3 3 3 1 Translin-associated factor X-interacting N-terminus Clathrin_H_link PF13838.4 T189596_2 - 7.2e-12 44.9 0.0 1.9e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Clathrin-H-link TSNAXIP1_N PF15739.3 T189596_3 - 0.0024 18.1 0.0 0.0039 17.4 0.0 1.3 1 0 0 1 1 1 1 Translin-associated factor X-interacting N-terminus Lipase_GDSL PF00657.20 T187023_1 - 2e-25 89.8 0.0 3.8e-20 72.6 0.0 2.2 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.4 T187023_1 - 0.00024 21.4 0.6 0.00089 19.6 0.6 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.20 T187023_3 - 1.6e-24 86.9 0.0 5e-22 78.7 0.0 2.4 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.4 T187023_3 - 3.5e-07 30.7 1.0 2.9e-06 27.7 0.2 2.7 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family zf-DBF PF07535.10 T206286_3 - 5.2e-06 26.3 1.0 5.2e-06 26.3 1.0 3.0 3 0 0 3 3 3 1 DBF zinc finger DUF3905 PF13045.4 T206286_3 - 0.15 12.0 0.5 2 8.4 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3905) TAFII55_N PF04658.11 T377729_1 - 1e-53 181.2 1.6 1e-53 181.2 1.6 2.1 2 1 1 3 3 3 1 TAFII55 protein conserved region TFB6 PF17110.3 T377729_1 - 9.3 5.8 16.3 0.042 13.5 6.4 2.0 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Integrin_alpha2 PF08441.10 T019398_1 - 1.1e-37 129.9 0.0 1.6e-37 129.4 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 T019398_1 - 1.3e-26 93.8 0.0 1.9e-26 93.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 T019398_1 - 2e-16 59.7 9.5 2.9e-06 27.2 0.8 3.6 3 0 0 3 3 3 3 FG-GAP repeat VCBS PF13517.4 T019398_1 - 7.1e-07 29.6 0.2 0.00013 22.3 0.3 2.5 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella VWA_2 PF13519.4 T019398_1 - 0.00017 22.1 0.0 0.00037 21.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 T019398_3 - 0.00031 20.9 0.0 0.00042 20.5 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain YadA_head PF05658.12 T277229_1 - 0.14 12.4 14.9 0.74 10.1 1.4 3.5 3 0 0 3 3 3 0 Head domain of trimeric autotransporter adhesin DUF3512 PF12024.6 T277229_2 - 2.7e-84 282.2 0.2 4.9e-84 281.4 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3512) Bromodomain PF00439.23 T277229_2 - 2.6e-22 78.5 0.0 8.6e-22 76.9 0.1 1.7 2 0 0 2 2 2 1 Bromodomain zf-DHHC PF01529.18 T277229_2 - 3.9e-19 68.9 10.8 3.9e-19 68.9 10.8 4.4 4 0 0 4 4 4 2 DHHC palmitoyltransferase SR-25 PF10500.7 T277229_2 - 0.2 11.1 14.7 0.44 10.0 14.7 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein YadA_head PF05658.12 T277229_2 - 0.24 11.7 11.4 0.66 10.3 3.1 2.6 2 0 0 2 2 2 0 Head domain of trimeric autotransporter adhesin TFIIF_alpha PF05793.10 T277229_2 - 0.33 9.4 15.5 0.48 8.8 15.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Med19 PF10278.7 T277229_2 - 0.78 9.5 19.8 1.6 8.5 19.8 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Pyridoxal_deC PF00282.17 T079125_1 - 7.1e-77 258.5 0.0 9.4e-77 258.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 T079125_1 - 4.5e-05 22.4 0.0 7e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 T079125_1 - 0.0036 16.5 0.0 0.0052 16.0 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.17 T079125_3 - 7.2e-18 64.3 0.0 9.7e-18 63.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain WSC PF01822.17 T085896_3 - 5.2e-30 103.3 16.9 3.8e-17 62.1 7.6 2.5 2 0 0 2 2 2 2 WSC domain Sulfotransfer_1 PF00685.25 T085896_3 - 0.0024 17.3 0.0 0.0046 16.3 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase domain RVP PF00077.18 T016949_1 - 6.3e-23 80.8 0.0 1.2e-22 80.0 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease dUTPase PF00692.17 T016949_1 - 7.1e-13 48.2 0.0 1.3e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 dUTPase gag-asp_proteas PF13975.4 T016949_1 - 0.0027 18.1 0.0 0.0049 17.3 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Gag_p24 PF00607.18 T016949_1 - 0.0087 15.8 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) zf-CCHC PF00098.21 T016949_1 - 0.19 11.8 6.3 0.12 12.4 2.8 2.8 2 0 0 2 2 2 0 Zinc knuckle Gag_p24 PF00607.18 T016949_2 - 9.9e-17 61.3 0.0 1.6e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) zf-CCHC_5 PF14787.4 T016949_2 - 1.4e-13 50.2 3.8 2.9e-13 49.1 3.8 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger IN_DBD_C PF00552.19 T016949_2 - 2e-08 33.2 0.8 4.6e-08 32.1 0.8 1.5 1 0 0 1 1 1 1 Integrase DNA binding domain HERV-K_env_2 PF13804.4 T016949_3 - 4.4e-33 114.3 0.0 7.2e-33 113.6 0.0 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GST_N PF02798.18 T016949_3 - 1.3e-19 70.1 0.0 2.4e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Gag_p10 PF02337.15 T016949_3 - 3.1e-16 58.8 0.2 6.5e-16 57.8 0.2 1.5 1 0 0 1 1 1 1 Retroviral GAG p10 protein GST_C_3 PF14497.4 T016949_3 - 3.6e-16 59.0 0.0 6.3e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 T016949_3 - 1.1e-14 54.3 0.0 1.9e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 T016949_3 - 0.002 17.7 0.3 0.0049 16.5 0.3 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain CRAL_TRIO PF00650.18 T218331_2 - 3.8e-32 111.1 0.0 5.7e-32 110.5 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.13 T218331_2 - 8.7e-07 28.9 0.8 1.7e-06 28.0 0.8 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.4 T218331_2 - 5.7e-06 26.3 0.0 1.1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Cation_ATPase_C PF00689.19 T028460_2 - 6.7e-44 149.6 2.9 6.7e-44 149.6 2.9 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.18 T028460_2 - 9.8e-39 132.8 4.2 4.1e-26 91.5 0.6 2.5 2 0 0 2 2 2 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.6 T028460_2 - 2e-26 92.1 0.6 2e-26 92.1 0.6 2.4 2 0 0 2 2 2 1 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.4 T028460_2 - 1.6e-19 69.6 0.0 2.9e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 T028460_2 - 1.3e-16 59.9 0.1 5.4e-16 57.9 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 T028460_2 - 3.6e-14 53.4 0.0 1.1e-11 45.4 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 T028460_2 - 4.7e-06 26.4 0.3 0.00051 19.7 0.3 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase WD40 PF00400.30 T370250_2 - 0.0019 18.9 3.5 0.5 11.2 0.1 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat zf-MYND PF01753.16 T370250_3 - 6.2e-07 29.3 12.7 2.7e-06 27.2 12.7 2.2 1 0 0 1 1 1 1 MYND finger HNH_3 PF13392.4 T370250_3 - 0.0019 17.8 0.2 0.004 16.8 0.2 1.4 1 0 0 1 1 1 1 HNH endonuclease ECH_1 PF00378.18 T125420_1 - 2.8e-90 301.9 0.0 4.2e-90 301.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 T125420_1 - 1.1e-10 41.5 0.0 1.4e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase RRM_1 PF00076.20 T125420_3 - 4.7e-17 61.4 0.0 7.1e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 T125420_3 - 0.0052 16.7 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Limkain b1 RRM_7 PF16367.3 T125420_3 - 0.0058 16.6 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.4 T125420_3 - 0.04 13.8 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 T125420_3 - 0.056 12.9 0.0 0.097 12.1 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 T125420_3 - 0.06 13.3 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif RRM_occluded PF16842.3 T125420_3 - 0.13 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Macoilin PF09726.7 T125420_3 - 0.17 10.3 26.2 0.27 9.6 26.2 1.2 1 0 0 1 1 1 0 Transmembrane protein LAP1C PF05609.10 T125420_3 - 4.6 6.1 18.4 7.4 5.4 18.4 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) VWD PF00094.23 T258097_3 - 1.4e-20 74.0 0.0 2.4e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain NIDO PF06119.12 T258097_3 - 9.5e-14 52.0 0.1 1.9e-13 51.1 0.1 1.5 1 0 0 1 1 1 1 Nidogen-like RRM_1 PF00076.20 T128460_3 - 6.5e-12 45.0 0.0 5.6e-06 25.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.22 T128460_3 - 1.8e-07 31.8 0.0 4.8e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 Exonuclease DUF3512 PF12024.6 T277255_2 - 6.1e-74 248.3 1.1 2.2e-66 223.6 1.7 2.5 3 0 0 3 3 3 2 Domain of unknown function (DUF3512) Bromodomain PF00439.23 T277255_2 - 1.7e-22 79.1 0.0 6.6e-22 77.2 0.1 1.8 2 0 0 2 2 2 1 Bromodomain YadA_head PF05658.12 T277255_2 - 0.035 14.4 4.7 0.15 12.4 0.6 2.5 2 0 0 2 2 2 0 Head domain of trimeric autotransporter adhesin SR-25 PF10500.7 T277255_2 - 0.25 10.8 15.2 0.49 9.8 15.2 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIF_alpha PF05793.10 T277255_2 - 0.26 9.7 15.5 0.37 9.2 15.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Med19 PF10278.7 T277255_2 - 0.63 9.8 19.8 1.2 8.9 19.8 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 YadA_head PF05658.12 T277255_3 - 0.22 11.8 3.1 0.51 10.7 3.1 1.6 1 0 0 1 1 1 0 Head domain of trimeric autotransporter adhesin TMEM210 PF15195.4 T369949_1 - 1.2e-28 99.7 0.8 2.4e-28 98.7 0.8 1.4 1 0 0 1 1 1 1 TMEM210 family Cullin PF00888.20 T369949_2 - 1.5e-30 106.3 0.1 2.8e-30 105.4 0.0 1.3 2 0 0 2 2 2 1 Cullin family ANAPC2 PF08672.9 T369949_2 - 2e-20 72.9 0.5 3.9e-20 72.0 0.5 1.5 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 LRR_8 PF13855.4 T369949_3 - 4.8e-27 93.4 1.8 1.6e-14 53.3 0.1 2.5 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 T369949_3 - 3.2e-08 33.5 1.4 0.0022 18.2 0.2 3.3 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 T369949_3 - 0.00073 18.9 0.0 0.0019 17.6 0.0 1.5 1 1 1 2 2 2 1 Leucine-rich repeat 7tm_1 PF00001.19 T055664_1 - 1e-14 54.3 27.7 1.6e-11 43.8 27.7 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TcpE PF12648.5 T055664_1 - 0.12 12.8 0.3 0.12 12.8 0.3 2.8 2 1 1 3 3 3 0 TcpE family ELMO_CED12 PF04727.11 T192942_2 - 2.1e-15 57.2 0.0 4.1e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family Beta_helix PF13229.4 T172551_1 - 2e-06 27.6 0.0 0.48 10.1 0.0 4.0 3 1 1 4 4 4 3 Right handed beta helix region Beta_helix PF13229.4 T172551_2 - 0.024 14.3 0.0 14 5.4 0.0 2.9 3 0 0 3 3 3 0 Right handed beta helix region Beta_helix PF13229.4 T172551_3 - 0.031 14.0 0.0 4.2 7.1 0.0 3.1 2 1 1 3 3 3 0 Right handed beta helix region DLH PF01738.16 T278876_3 - 1.9e-36 125.6 0.0 2.4e-36 125.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.14 T278876_3 - 0.0015 18.2 0.0 0.0025 17.5 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DUF915 PF06028.9 T278876_3 - 0.007 15.6 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) BAAT_C PF08840.9 T278876_3 - 0.015 15.1 0.2 0.2 11.4 0.1 1.9 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.11 T278876_3 - 0.02 14.4 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) ATP-synt_C PF00137.19 T079429_3 - 3e-10 40.2 12.4 5.2e-10 39.4 12.4 1.4 1 0 0 1 1 1 1 ATP synthase subunit C CHDCT2 PF08074.9 T141147_2 - 2.3e-63 213.3 0.5 5.2e-63 212.2 0.5 1.6 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF1086 PF06461.9 T141147_2 - 8.4e-62 207.0 0.0 2.6e-61 205.4 0.0 1.9 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.21 T141147_2 - 3.3e-61 206.8 0.0 7.5e-61 205.6 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain CHDNT PF08073.10 T141147_2 - 2.7e-26 91.1 0.4 6.4e-26 89.9 0.4 1.7 1 0 0 1 1 1 1 CHDNT (NUC034) domain DUF1087 PF06465.11 T141147_2 - 6.5e-25 86.9 6.6 6.5e-25 86.9 6.6 4.2 4 1 0 4 4 1 1 Domain of Unknown Function (DUF1087) Helicase_C PF00271.29 T141147_2 - 1.3e-21 76.9 0.0 2.4e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 T141147_2 - 3e-20 71.7 26.4 1.8e-10 40.4 7.3 2.6 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.22 T141147_2 - 3.2e-19 68.4 6.8 9.1e-14 51.0 2.5 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 T141147_2 - 1.8e-08 34.5 0.0 5.3e-08 32.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 T141147_2 - 4.9e-08 32.3 0.0 1.3e-07 31.0 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 HMG_box PF00505.17 T141147_2 - 0.0036 17.6 0.2 0.0036 17.6 0.2 2.3 2 0 0 2 2 1 1 HMG (high mobility group) box DEAD PF00270.27 T141147_2 - 0.0064 16.1 0.0 0.02 14.6 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase PHD_2 PF13831.4 T141147_2 - 0.054 12.9 11.5 0.29 10.6 3.1 2.7 2 0 0 2 2 2 0 PHD-finger AAA_22 PF13401.4 T141147_2 - 0.13 12.4 0.0 0.5 10.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain zf-PHD-like PF15446.4 T141147_2 - 3.2 7.2 15.5 0.98 8.9 0.7 3.1 1 1 2 3 3 3 0 PHD/FYVE-zinc-finger like domain CHDCT2 PF08074.9 T141147_3 - 8.5e-18 65.0 0.0 1.3e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain An_peroxidase PF03098.13 T183118_2 - 1.2e-179 598.1 0.0 1.5e-179 597.8 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase EGF_CA PF07645.13 T183118_2 - 2.3e-10 40.4 5.8 2.3e-10 40.4 5.8 2.7 3 0 0 3 3 3 1 Calcium-binding EGF domain Sushi PF00084.18 T183118_2 - 6.3e-06 26.6 2.6 6.3e-06 26.6 2.6 2.0 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) EGF_3 PF12947.5 T183118_2 - 0.00024 21.1 7.3 0.00092 19.2 7.3 2.1 1 0 0 1 1 1 1 EGF domain FXa_inhibition PF14670.4 T183118_2 - 0.003 17.7 8.1 0.003 17.7 8.1 3.1 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.5 T183118_2 - 0.72 9.7 16.6 0.49 10.3 2.2 3.3 3 0 0 3 3 3 0 Complement Clr-like EGF-like IPK PF03770.14 T242288_2 - 6.7e-61 205.5 0.0 1.1e-60 204.8 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase CENP-N PF05238.11 T136837_2 - 2.3e-39 135.8 1.6 2.8e-39 135.5 1.6 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like Collagen_bind PF05737.10 T136837_2 - 0.041 13.9 0.1 0.059 13.4 0.1 1.2 1 0 0 1 1 1 0 Collagen binding domain DUF4976 PF16347.3 T136837_2 - 0.044 13.9 0.1 0.088 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) PAP_assoc PF03828.17 T284789_3 - 1.6e-12 47.3 0.0 3.4e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase fn3 PF00041.19 T284789_3 - 2.1e-10 40.7 0.2 1.1e-05 25.5 0.0 2.6 2 0 0 2 2 2 2 Fibronectin type III domain SPRY PF00622.26 T284789_3 - 0.00036 20.5 0.0 0.00063 19.7 0.0 1.4 1 0 0 1 1 1 1 SPRY domain NTP_transf_2 PF01909.21 T284789_3 - 0.018 15.2 0.0 0.035 14.3 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase domain PTRF_SDPR PF15237.4 T363848_1 - 3.2e-89 298.6 25.8 4.3e-89 298.2 25.8 1.2 1 0 0 1 1 1 1 PTRF/SDPR family COG5 PF10392.7 T363848_1 - 8.6 6.4 11.9 6.4 6.8 5.3 2.4 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Kazal_2 PF07648.13 T363848_3 - 1.1e-16 60.6 12.4 1.6e-08 34.5 2.5 3.2 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 T363848_3 - 9.9e-10 38.1 28.7 9.9e-05 22.1 12.7 3.1 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Sulfotransfer_1 PF00685.25 T266074_2 - 2e-91 306.1 0.7 2.5e-91 305.7 0.7 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 T266074_2 - 0.0079 16.5 0.0 0.18 12.0 0.0 2.2 2 0 0 2 2 2 1 Sulfotransferase family zf-C2H2 PF00096.24 T254288_2 - 1.8e-40 135.0 55.1 7.5e-07 29.1 1.4 9.0 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T254288_2 - 9.5e-31 104.7 55.9 5.1e-08 32.9 1.2 10.3 10 0 0 10 10 10 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 T254288_2 - 5.9e-27 91.9 53.6 0.0011 19.5 0.7 9.6 9 0 0 9 9 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T254288_2 - 9.9e-11 41.2 44.9 0.00018 21.2 0.2 8.2 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T254288_2 - 3.7e-09 36.5 48.1 0.0032 17.6 0.8 9.5 10 0 0 10 10 9 6 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 T254288_2 - 3.3e-06 26.6 57.0 6.2e-05 22.5 2.4 8.0 8 1 0 8 8 7 5 C2H2-type zinc-finger domain zf-BED PF02892.13 T254288_2 - 0.00098 19.0 0.7 0.00098 19.0 0.7 6.3 4 2 3 7 7 7 3 BED zinc finger zf-C2H2_11 PF16622.3 T254288_2 - 0.0013 18.3 32.2 0.072 12.7 0.8 7.2 8 0 0 8 8 8 3 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 T254288_2 - 0.0023 18.5 23.4 0.45 11.2 0.6 5.3 4 1 1 5 5 5 3 zinc-ribbon family Zn-ribbon_8 PF09723.8 T254288_2 - 0.0024 17.8 31.9 0.012 15.5 1.6 6.7 6 1 0 6 6 6 2 Zinc ribbon domain PyrI_C PF02748.13 T254288_2 - 0.036 13.8 21.6 0.48 10.2 0.0 6.3 5 1 1 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-met PF12874.5 T254288_2 - 0.11 12.8 41.2 0.51 10.7 0.3 8.1 8 0 0 8 8 8 0 Zinc-finger of C2H2 type BolA PF01722.16 T254288_2 - 0.43 10.8 2.4 28 5.0 0.1 4.0 3 2 0 3 3 3 0 BolA-like protein GAGA PF09237.9 T254288_2 - 0.44 10.3 14.2 3.6 7.3 0.1 4.6 2 1 2 4 4 4 0 GAGA factor DHC_N2 PF08393.11 T243337_1 - 3.5e-144 480.7 14.5 3.5e-144 480.7 14.5 2.8 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 T243337_1 - 6e-99 330.3 0.1 1.6e-98 329.0 0.0 1.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.5 T243337_1 - 1.2e-81 273.7 0.1 2.7e-81 272.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 T243337_1 - 6.9e-51 173.0 0.0 1.6e-50 171.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.5 T243337_1 - 8.3e-35 120.3 6.5 1.4e-34 119.5 6.5 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 T243337_1 - 9.8e-17 61.1 0.0 7.2e-06 25.9 0.0 5.7 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.4 T243337_1 - 2.4e-08 34.4 0.1 0.15 12.5 0.0 6.1 5 0 0 5 5 5 1 AAA domain AAA_16 PF13191.4 T243337_1 - 1.2e-07 32.2 0.1 0.45 10.7 0.0 4.9 4 0 0 4 4 4 1 AAA ATPase domain AAA PF00004.27 T243337_1 - 1.7e-07 31.6 1.1 3.3 8.0 0.0 5.3 6 0 0 6 6 5 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 T243337_1 - 2e-07 31.2 0.1 0.62 10.2 0.0 4.8 4 0 0 4 4 4 2 AAA domain T2SSE PF00437.18 T243337_1 - 0.00061 18.8 4.3 0.52 9.2 0.0 3.5 4 0 0 4 4 4 2 Type II/IV secretion system protein RNA_helicase PF00910.20 T243337_1 - 0.00067 19.9 0.2 3.6 7.9 0.0 4.2 4 0 0 4 4 3 1 RNA helicase ResIII PF04851.13 T243337_1 - 0.0015 18.4 0.0 1.6 8.6 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Mg_chelatase PF01078.19 T243337_1 - 0.0015 17.8 0.0 0.29 10.4 0.0 3.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.4 T243337_1 - 0.0019 18.2 0.2 1.2 9.2 0.1 3.4 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.25 T243337_1 - 0.002 18.5 0.4 0.25 11.7 0.0 3.3 3 0 0 3 3 3 1 ABC transporter DEAD PF00270.27 T243337_1 - 0.01 15.5 0.1 6.9 6.3 0.0 3.3 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_30 PF13604.4 T243337_1 - 0.025 14.2 4.0 5.5 6.5 0.1 3.3 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.4 T243337_1 - 0.029 14.6 1.2 8.2 6.6 0.0 3.9 4 0 0 4 4 3 0 AAA domain Cytidylate_kin PF02224.16 T243337_1 - 0.033 13.8 0.4 1.3 8.6 0.0 3.1 4 0 0 4 4 3 0 Cytidylate kinase AAA_29 PF13555.4 T243337_1 - 0.047 13.3 3.3 0.25 11.0 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain Seryl_tRNA_N PF02403.20 T243337_1 - 0.055 13.6 0.0 0.055 13.6 0.0 3.7 4 0 0 4 4 2 0 Seryl-tRNA synthetase N-terminal domain T2SSM PF04612.10 T243337_1 - 0.094 12.6 0.0 0.39 10.6 0.0 2.0 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Spc7 PF08317.9 T243337_1 - 0.34 9.6 18.4 1.5 7.5 1.4 3.4 3 0 0 3 3 3 0 Spc7 kinetochore protein zf-C4H2 PF10146.7 T243337_1 - 0.58 10.3 3.2 3 8.0 3.2 2.3 1 0 0 1 1 1 0 Zinc finger-containing protein TsaE PF02367.15 T243337_1 - 0.71 9.8 4.6 4.7 7.1 0.1 3.4 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.14 T243337_1 - 0.82 9.0 4.0 1.6 8.0 0.0 2.9 3 0 0 3 3 3 0 PhoH-like protein Alanine_zipper PF11839.6 T243337_1 - 2.7 8.2 8.5 7.6 6.7 8.5 1.7 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein AAA_25 PF13481.4 T243337_1 - 3.7 6.9 6.0 4.2 6.8 0.1 3.1 3 0 0 3 3 3 0 AAA domain ISG65-75 PF11727.6 T243337_1 - 4.6 6.3 9.7 9.7 5.2 9.7 1.5 1 0 0 1 1 1 0 Invariant surface glycoprotein Dynein_heavy PF03028.13 T243337_2 - 7.1e-233 774.7 0.0 1.3e-232 773.9 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.5 T243337_2 - 2.7e-91 304.5 0.6 6.5e-90 299.9 0.7 2.2 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 DUF4147 PF13660.4 T243337_2 - 2.8e-24 85.8 0.0 4.3e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MT PF12777.5 T243337_2 - 2e-09 36.8 0.0 2.9e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.13 T243337_3 - 9.6e-37 126.4 0.0 1.3e-36 126.0 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Retrotrans_gag PF03732.15 T378755_1 - 0.00088 19.4 0.0 0.0017 18.4 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein VAD1-2 PF15310.4 T378755_3 - 0.16 11.8 1.7 0.26 11.0 1.7 1.2 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling KxDL PF10241.7 T170704_1 - 9.4e-30 102.6 2.0 1.4e-29 102.0 2.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein ubiquitin PF00240.21 T170704_3 - 1.8e-33 114.0 0.3 2.5e-33 113.5 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.15 T170704_3 - 7.7e-32 108.8 12.3 1.4e-31 107.9 12.3 1.5 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.6 T170704_3 - 1.4e-15 56.7 0.4 2e-15 56.2 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 T170704_3 - 0.00016 21.9 0.1 0.0003 21.0 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 T170704_3 - 0.12 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like WWE PF02825.18 T311090_1 - 2.5e-15 56.6 2.5 4.7e-15 55.7 2.5 1.5 1 0 0 1 1 1 1 WWE domain zf-C3HC4_3 PF13920.4 T311090_1 - 9.1e-06 25.3 10.7 9.1e-06 25.3 10.7 3.0 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T311090_1 - 0.0012 18.7 10.3 0.0048 16.7 10.3 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 T311090_1 - 0.0013 18.8 12.6 0.0013 18.8 12.6 2.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.23 T311090_1 - 0.002 17.8 11.6 0.002 17.8 11.6 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T311090_1 - 0.033 13.9 17.8 0.0085 15.8 12.0 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T311090_1 - 0.073 13.1 11.5 0.32 11.1 11.5 2.2 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 T311090_1 - 0.074 12.9 11.4 0.31 10.9 11.4 2.2 1 0 0 1 1 1 0 zinc-RING finger domain ABC_tran PF00005.25 T153216_1 - 5.2e-114 376.7 2.0 5.7e-32 111.0 0.1 4.4 4 0 0 4 4 4 4 ABC transporter ABC2_membrane_3 PF12698.5 T153216_1 - 3.3e-69 233.5 135.4 5e-29 101.4 30.7 4.8 4 0 0 4 4 4 4 ABC-2 family transporter protein AAA_21 PF13304.4 T153216_1 - 1.2e-24 87.6 13.8 2.5e-06 27.4 0.1 7.0 6 1 1 7 7 7 5 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 T153216_1 - 4.6e-17 62.3 2.0 0.00069 19.4 0.0 4.3 4 0 0 4 4 4 4 Protein of unknown function, DUF258 AAA_29 PF13555.4 T153216_1 - 2.7e-12 46.1 8.2 0.017 14.7 0.0 4.4 4 0 0 4 4 4 4 P-loop containing region of AAA domain AAA_23 PF13476.4 T153216_1 - 2.2e-09 38.0 19.2 0.0069 16.8 0.1 5.1 5 0 0 5 5 5 3 AAA domain MMR_HSR1 PF01926.21 T153216_1 - 4.3e-08 33.1 4.0 0.53 10.3 0.1 4.6 4 0 0 4 4 4 3 50S ribosome-binding GTPase AAA_16 PF13191.4 T153216_1 - 5e-07 30.1 0.0 1 9.6 0.0 4.3 4 0 0 4 4 4 1 AAA ATPase domain SMC_N PF02463.17 T153216_1 - 2.6e-05 23.6 10.3 0.019 14.3 0.3 6.0 5 2 0 5 5 5 1 RecF/RecN/SMC N terminal domain DUF4162 PF13732.4 T153216_1 - 8.8e-05 23.0 1.0 9.6 6.9 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4162) AAA_15 PF13175.4 T153216_1 - 0.00014 21.5 15.5 0.26 10.7 1.8 5.6 5 1 0 5 5 5 2 AAA ATPase domain AAA_25 PF13481.4 T153216_1 - 0.00016 21.2 0.9 0.17 11.3 0.0 3.7 4 0 0 4 4 4 1 AAA domain AAA_30 PF13604.4 T153216_1 - 0.00034 20.3 1.6 18 4.8 0.0 4.2 4 0 0 4 4 4 0 AAA domain AAA_24 PF13479.4 T153216_1 - 0.00053 19.6 0.8 2.7 7.5 0.0 4.0 4 0 0 4 4 4 1 AAA domain ATP-synt_ab PF00006.23 T153216_1 - 0.00055 19.5 0.2 1.5 8.3 0.0 3.7 4 0 0 4 4 4 1 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.21 T153216_1 - 0.0012 18.7 2.4 1.4 8.8 0.0 3.8 4 1 0 4 4 4 1 Dynamin family IstB_IS21 PF01695.15 T153216_1 - 0.0045 16.6 0.5 6 6.5 0.0 4.5 4 0 0 4 4 4 1 IstB-like ATP binding protein cobW PF02492.17 T153216_1 - 0.081 12.4 4.6 14 5.1 0.0 4.0 4 0 0 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.4 T153216_1 - 0.11 12.6 8.5 8.8 6.5 0.2 4.3 4 0 0 4 4 4 0 AAA domain Zeta_toxin PF06414.10 T153216_1 - 0.13 11.4 0.3 17 4.5 0.0 3.2 3 0 0 3 3 3 0 Zeta toxin AAA_27 PF13514.4 T153216_1 - 0.18 11.3 0.8 20 4.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.20 T153216_1 - 1.2 9.4 8.3 29 5.0 0.0 4.4 5 0 0 5 5 5 0 RNA helicase ArgK PF03308.14 T153216_1 - 4 6.2 4.5 28 3.4 0.1 3.2 4 0 0 4 4 4 0 ArgK protein AAA_33 PF13671.4 T153216_1 - 5.5 7.0 6.4 58 3.7 0.1 3.9 4 0 0 4 4 4 0 AAA domain AAA_21 PF13304.4 T153216_3 - 0.066 12.9 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system V-set PF07686.15 T100773_2 - 7.8e-12 45.2 0.0 1.5e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T100773_2 - 0.00025 21.2 0.2 0.0022 18.2 0.2 2.1 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 T100773_2 - 0.024 15.1 0.0 0.044 14.3 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.15 T100773_3 - 2.2e-10 40.5 0.1 3.5e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T100773_3 - 4.9e-06 26.9 0.1 9.8e-06 26.0 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T100773_3 - 0.0079 16.2 0.1 0.073 13.1 0.1 2.3 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T100773_3 - 0.017 15.3 0.2 0.052 13.8 0.2 1.7 1 1 0 1 1 1 0 Immunoglobulin domain zf-C2H2 PF00096.24 T297545_1 - 5e-17 61.2 40.8 0.00017 21.7 1.6 6.1 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T297545_1 - 1.5e-08 34.6 11.9 5.5e-06 26.5 0.8 5.5 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 T297545_1 - 1.4e-07 31.6 35.0 0.024 15.3 1.9 6.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T297545_1 - 2.7e-06 27.4 39.4 0.022 14.9 0.9 5.9 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 T297545_1 - 0.0029 17.2 6.0 0.0029 17.2 6.0 5.8 5 0 0 5 5 5 3 C2H2-type zinc-finger domain FYDLN_acid PF09538.8 T297545_1 - 0.55 10.8 6.3 2.9 8.5 4.5 3.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) NOA36 PF06524.10 T297545_1 - 2.6 7.2 25.8 0.11 11.7 10.1 3.0 3 0 0 3 3 3 0 NOA36 protein zf-met PF12874.5 T297545_1 - 6.5 7.2 40.1 1.1 9.6 0.7 5.4 5 0 0 5 5 5 0 Zinc-finger of C2H2 type DUF4662 PF15578.4 T231733_2 - 1.9e-154 513.1 2.0 2.2e-154 512.8 2.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4662) Pkinase PF00069.23 T130011_3 - 5.8e-63 212.6 0.0 1.2e-62 211.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T130011_3 - 5.1e-43 147.1 0.0 8.8e-43 146.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TMEM219 PF14940.4 T130011_3 - 4.9e-16 58.9 0.1 2.7e-08 33.5 0.0 2.4 1 1 1 2 2 2 2 Transmembrane 219 AAA-ATPase_like PF09820.7 T130011_3 - 0.52 9.5 9.5 0.042 13.1 4.1 1.8 2 0 0 2 2 2 0 Predicted AAA-ATPase An_peroxidase PF03098.13 T366023_1 - 4.5e-47 160.7 0.0 6.3e-27 94.2 0.0 3.1 1 1 2 3 3 3 3 Animal haem peroxidase EGF PF00008.25 T366023_1 - 0.00018 21.6 12.7 0.00055 20.0 12.7 1.9 1 0 0 1 1 1 1 EGF-like domain DUF4701 PF15773.3 T126628_1 - 3.5e-143 478.1 10.8 4.7e-143 477.7 10.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4701) FYVE PF01363.19 T259648_2 - 1.3e-09 38.0 4.8 1.3e-09 38.0 4.8 2.1 2 0 0 2 2 2 1 FYVE zinc finger THEG PF14912.4 T165159_1 - 8.2e-29 99.7 22.7 5.2e-17 61.9 3.7 4.4 3 1 2 5 5 5 5 Testicular haploid expressed repeat Aldolase_II PF00596.19 T165159_1 - 0.075 12.8 0.0 42 3.9 0.0 3.0 3 0 0 3 3 3 0 Class II Aldolase and Adducin N-terminal domain Aldolase_II PF00596.19 T165159_2 - 0.024 14.4 0.0 33 4.2 0.0 3.1 3 0 0 3 3 3 0 Class II Aldolase and Adducin N-terminal domain IGFL PF14653.4 T151909_2 - 0.18 11.6 2.7 0.48 10.3 2.7 1.6 1 0 0 1 1 1 0 Insulin growth factor-like family Miff PF05644.9 T209049_1 - 5.4e-141 469.3 1.9 6.6e-141 469.0 1.9 1.1 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff R3H PF01424.20 T080522_1 - 3.1e-10 39.8 0.0 6.1e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 R3H domain B12D PF06522.9 T080522_3 - 2.5e-26 91.1 0.0 4.7e-26 90.2 0.0 1.5 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit SH3_2 PF07653.15 T080522_3 - 4.4e-13 48.6 1.2 4.3e-06 26.2 0.2 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.4 T080522_3 - 7.3e-13 48.0 0.3 3e-10 39.7 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 T080522_3 - 1.1e-12 47.2 0.8 2e-12 46.4 0.2 1.7 2 0 0 2 2 2 1 SH3 domain C1_1 PF00130.20 T080522_3 - 2.5e-08 33.5 11.8 8.6e-08 31.8 11.8 2.0 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) STAC2_u1 PF16664.3 T080522_3 - 2.8e-07 30.9 0.1 5.5e-07 30.0 0.1 1.4 1 0 0 1 1 1 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF1725 PF08333.9 T377022_3 - 0.0019 17.7 1.3 0.0054 16.2 1.3 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) ATG16 PF08614.9 T377022_3 - 0.0019 18.3 21.1 0.18 11.8 11.6 2.2 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) LRRFIP PF09738.7 T377022_3 - 0.03 13.7 23.1 0.023 14.1 3.1 2.1 1 1 1 2 2 2 0 LRRFIP family KASH_CCD PF14662.4 T377022_3 - 0.093 12.4 25.8 0.6 9.8 25.4 2.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Fez1 PF06818.13 T377022_3 - 0.57 10.5 23.5 0.71 10.1 3.5 2.2 1 1 1 2 2 2 0 Fez1 DUF2968 PF11180.6 T377022_3 - 0.98 9.0 6.8 0.97 9.0 2.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) HMMR_N PF15905.3 T377022_3 - 1.4 8.2 21.6 3.5 6.9 11.6 2.4 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal ADIP PF11559.6 T377022_3 - 1.5 8.7 24.8 0.093 12.7 4.0 2.8 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.10 T377022_3 - 3.5 6.8 5.2 5.4 6.2 0.2 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Sema PF01403.17 T242704_1 - 9.5e-45 153.0 0.0 1.4e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 T242704_1 - 1.6e-22 79.2 0.3 1.2e-09 37.9 0.1 3.9 3 0 0 3 3 3 3 IPT/TIG domain Pkinase_Tyr PF07714.15 T242704_3 - 6.6e-86 287.7 0.0 8.8e-86 287.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T242704_3 - 1e-34 120.0 0.0 1.5e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 T242704_3 - 0.0013 18.0 0.0 0.0018 17.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like ABC2_membrane_3 PF12698.5 T015454_1 - 4.9e-44 150.7 7.0 6.9e-44 150.2 7.0 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.25 T015454_1 - 1.7e-21 77.0 0.0 3e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 T015454_1 - 1.9e-08 34.3 0.1 6.5e-06 26.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.4 T015454_1 - 0.06 14.0 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) AAA_15 PF13175.4 T015454_1 - 0.079 12.4 0.0 0.3 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Casc1_N PF15927.3 T075424_3 - 2.5e-62 210.0 21.1 2.5e-62 210.0 21.1 2.7 3 0 0 3 3 3 1 Cancer susceptibility candidate 1 N-terminus Lactamase_B_2 PF12706.5 T075424_3 - 0.16 11.3 0.1 0.31 10.4 0.1 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain TPR_1 PF00515.26 T149292_1 - 5.7e-42 139.8 4.4 2.9e-09 36.2 0.2 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.15 T149292_1 - 1.3e-26 90.4 4.7 1.5e-05 24.6 0.1 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.4 T149292_1 - 1.4e-23 80.9 3.4 0.00036 20.4 0.2 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.4 T149292_1 - 4.8e-21 74.0 10.8 2.2e-06 27.1 0.1 7.3 3 2 6 9 9 9 5 TPR repeat TPR_12 PF13424.4 T149292_1 - 5.6e-20 71.3 0.1 1.1e-05 25.5 0.0 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.4 T149292_1 - 1.2e-19 69.0 2.3 0.0083 16.3 0.0 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.4 T149292_1 - 4.2e-16 59.2 0.0 7.8e-08 32.8 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.4 T149292_1 - 9.2e-13 48.4 0.0 0.074 13.4 0.0 5.2 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.4 T149292_1 - 3.5e-12 45.9 0.1 0.016 15.8 0.0 6.3 2 1 4 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.4 T149292_1 - 1.3e-10 41.2 0.0 0.00013 21.9 0.0 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.4 T149292_1 - 5.7e-09 35.9 0.9 0.4 11.3 0.0 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.5 T149292_1 - 5e-08 32.9 10.3 0.0015 18.6 0.5 4.5 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.8 T149292_1 - 3.8e-05 22.7 1.0 0.0075 15.2 0.0 2.1 1 1 1 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.4 T149292_1 - 0.00011 21.8 0.0 11 6.2 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_15 PF13429.4 T149292_1 - 0.011 14.9 0.0 2.6 7.1 0.0 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 T149292_1 - 0.18 11.6 0.0 4 7.3 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat EF-hand_1 PF00036.30 T118638_2 - 1.2e-07 30.6 0.6 7.9e-05 21.8 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 T118638_2 - 1.6e-06 27.4 2.2 5.5e-05 22.7 0.1 2.7 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.4 T118638_2 - 3.4e-05 23.0 0.2 0.0081 15.5 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 T118638_2 - 0.0046 17.3 0.1 0.029 14.7 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain pair NAD_binding_6 PF08030.10 T118638_3 - 3e-30 105.3 0.0 4.6e-30 104.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.10 T118638_3 - 1.6e-20 73.1 0.0 2.9e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.17 T118638_3 - 9.4e-20 70.9 9.6 9.4e-20 70.9 9.6 2.5 2 0 0 2 2 2 1 Ferric reductase like transmembrane component EF-hand_5 PF13202.4 T118638_3 - 1.7e-05 24.0 0.2 0.007 15.7 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.30 T118638_3 - 3.1e-05 23.1 0.0 0.0053 16.1 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 T118638_3 - 0.00062 19.4 0.0 0.22 11.4 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.4 T118638_3 - 0.0029 17.9 0.1 0.005 17.2 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair NAD_binding_1 PF00175.19 T118638_3 - 0.0044 17.5 0.0 0.092 13.3 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain EF-hand_8 PF13833.4 T118638_3 - 0.0086 15.7 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair FAD_binding_6 PF00970.22 T118638_3 - 0.075 13.3 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Wbp11 PF09429.8 T074468_1 - 1.9e-22 79.3 14.1 1.9e-22 79.3 14.1 1.9 2 0 0 2 2 2 1 WW domain binding protein 11 BSP_II PF05432.9 T074468_1 - 6.6 6.2 20.4 9.7 5.7 20.4 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4533 PF15047.4 T074468_2 - 2.5e-61 207.1 9.8 3.5e-60 203.4 9.8 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF4533) ART PF01129.16 T074468_3 - 7.3e-50 169.2 1.1 1e-49 168.7 1.1 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase zf-RING_4 PF14570.4 T333910_3 - 2.5e-19 68.6 12.2 2.5e-19 68.6 12.2 2.1 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.4 T333910_3 - 8.3e-06 25.4 7.4 8.3e-06 25.4 7.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.20 T333910_3 - 3.3e-05 23.5 0.0 6.4e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-UDP PF14569.4 T333910_3 - 0.13 12.2 3.6 0.3 11.1 3.6 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger SRP14 PF02290.13 T114646_1 - 3.4e-25 88.1 0.1 5.9e-25 87.4 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle 14kD protein DUF2722 PF10846.6 T114646_2 - 0.0023 16.8 5.8 0.0028 16.5 5.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Asp PF00026.21 T059663_2 - 7e-124 413.2 6.1 8.7e-124 412.9 6.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 T059663_2 - 6e-14 52.6 3.2 3.4e-12 46.8 3.2 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 T059663_2 - 2.3e-10 40.0 3.5 4.4e-10 39.1 3.5 1.4 1 0 0 1 1 1 1 A1 Propeptide Cation_ATPase_C PF00689.19 T237930_2 - 1.1e-44 152.2 3.1 1.1e-44 152.2 3.1 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.18 T237930_2 - 1e-37 129.5 6.9 2.1e-25 89.2 0.8 2.4 2 0 0 2 2 2 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.6 T237930_2 - 6e-26 90.6 0.1 1.4e-25 89.4 0.1 1.7 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.4 T237930_2 - 1.3e-17 63.5 0.0 2.4e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 T237930_2 - 1.4e-13 51.5 0.1 1.3e-12 48.4 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 T237930_2 - 2.5e-13 49.4 0.0 5.8e-13 48.2 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 T237930_2 - 1e-05 25.3 2.0 0.00013 21.7 0.4 2.3 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase SSrecog PF03531.12 T058889_2 - 4.6e-87 290.8 0.0 6.8e-87 290.3 0.0 1.3 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Tankyrase_bdg_C PF15327.4 T058889_2 - 4.9e-63 212.5 6.7 4.9e-63 212.5 6.7 4.0 3 0 0 3 3 3 1 Tankyrase binding protein C terminal domain Rtt106 PF08512.10 T058889_2 - 2.9e-26 91.6 0.2 8.8e-26 90.0 0.1 1.9 2 0 0 2 2 2 1 Histone chaperone Rttp106-like HMG_box PF00505.17 T058889_2 - 1e-23 83.4 5.2 2.1e-23 82.4 5.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T058889_2 - 2.1e-12 47.3 4.6 5.1e-12 46.1 4.6 1.7 1 0 0 1 1 1 1 HMG-box domain Pkinase PF00069.23 T177720_1 - 7.8e-69 231.8 0.0 1.1e-68 231.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T177720_1 - 1.4e-31 109.6 0.0 2.1e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 T177720_1 - 6.4e-24 83.5 26.3 6.8e-13 48.2 2.6 2.9 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.14 T177720_1 - 1.8e-06 28.0 14.8 0.0052 16.9 5.4 2.7 2 0 0 2 2 2 2 C1 domain Kinase-like PF14531.4 T177720_1 - 0.00011 21.5 0.0 0.00056 19.2 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.12 T177720_1 - 0.00023 20.4 0.0 0.00041 19.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_9 PF13901.4 T177720_1 - 0.35 10.7 12.7 1.2 8.9 0.4 2.2 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD_2 PF13831.4 T177720_1 - 1 8.8 4.7 15 5.0 0.1 3.0 2 0 0 2 2 2 0 PHD-finger WD40 PF00400.30 T177720_2 - 3e-33 113.2 15.4 2.7e-09 37.4 0.4 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat Striatin PF08232.10 T177720_2 - 8.4e-24 84.8 0.8 2.5e-23 83.2 0.8 1.8 1 1 0 1 1 1 1 Striatin family ANAPC4_WD40 PF12894.5 T177720_2 - 6.9e-09 35.8 0.0 0.097 12.8 0.0 4.5 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 T177720_2 - 0.00045 18.8 0.0 0.75 8.2 0.0 3.0 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.9 T177720_2 - 0.13 10.8 0.0 7.3 5.1 0.0 2.6 3 0 0 3 3 3 0 Nup133 N terminal like VWA_N PF08399.9 T243788_3 - 6.1e-37 126.7 0.1 1.2e-36 125.8 0.1 1.5 1 0 0 1 1 1 1 VWA N-terminal VGCC_alpha2 PF08473.9 T243788_3 - 3.4e-30 105.1 3.6 5.7e-30 104.3 3.6 1.3 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_3 PF13768.4 T243788_3 - 1.9e-14 53.7 0.0 3.2e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.16 T243788_3 - 3e-13 50.0 2.1 7.9e-12 45.4 0.1 3.2 3 0 0 3 3 3 1 Cache domain VWA PF00092.26 T243788_3 - 1.9e-11 44.4 0.1 3.5e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 T243788_3 - 5.5e-09 36.5 0.1 1.2e-08 35.5 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_2 PF08269.9 T243788_3 - 0.0054 15.8 0.0 0.0054 15.8 0.0 2.3 3 0 0 3 3 3 1 Cache domain Cache_3-Cache_2 PF17201.2 T243788_3 - 0.023 13.8 0.0 0.058 12.5 0.1 1.6 2 0 0 2 2 2 0 Cache 3/Cache 2 fusion domain VWA_CoxE PF05762.12 T243788_3 - 0.034 13.4 0.0 0.063 12.5 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Phage_holin_6_1 PF09682.8 T243788_3 - 0.22 11.8 1.3 0.45 10.8 1.3 1.4 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) RskA PF10099.7 T243788_3 - 1 9.5 6.2 1.8 8.7 6.2 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Myosin_head PF00063.19 T216685_1 - 5.7e-65 219.7 0.0 7.9e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_head PF00063.19 T216685_2 - 2.1e-191 637.5 0.3 1.5e-81 274.5 0.0 4.0 4 0 0 4 4 4 4 Myosin head (motor domain) Myosin_N PF02736.17 T216685_2 - 5e-12 45.3 3.6 8.6e-12 44.5 3.6 1.4 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain HBM PF16591.3 T216685_2 - 0.11 11.7 0.3 0.2 10.9 0.3 1.3 1 0 0 1 1 1 0 Helical bimodular sensor domain Myosin_tail_1 PF01576.17 T216685_3 - 1.1e-138 463.8 259.0 1.3e-138 463.5 259.0 1.0 1 0 0 1 1 1 1 Myosin tail Filament PF00038.19 T216685_3 - 0.0008 19.0 49.7 0.0008 19.0 49.7 6.5 1 1 5 6 6 6 2 Intermediate filament protein Reo_sigmaC PF04582.10 T216685_3 - 0.0022 17.3 52.9 0.0046 16.3 2.1 7.1 4 4 5 9 9 9 8 Reovirus sigma C capsid protein ChaC PF04752.10 T114935_1 - 1.6e-45 155.2 1.1 6.5e-31 107.6 1.2 2.2 1 1 1 2 2 2 2 ChaC-like protein Caldesmon PF02029.13 T052935_1 - 2.2e-24 86.0 22.7 8.7e-24 84.0 4.1 2.2 2 0 0 2 2 2 2 Caldesmon Troponin PF00992.18 T052935_2 - 1.7e-31 109.2 34.3 1.7e-31 109.2 34.3 2.9 2 1 1 3 3 3 2 Troponin Tetraspannin PF00335.18 T076249_1 - 9.9e-38 129.9 1.1 1.5e-37 129.3 1.1 1.3 1 0 0 1 1 1 1 Tetraspanin family Tetraspannin PF00335.18 T076249_2 - 0.0002 21.1 0.1 0.00031 20.5 0.1 1.2 1 0 0 1 1 1 1 Tetraspanin family P53 PF00870.16 T256920_1 - 7.2e-110 365.0 0.5 1.3e-109 364.2 0.5 1.4 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 T256920_1 - 2.3e-18 65.1 0.2 5.3e-18 63.9 0.2 1.6 1 0 0 1 1 1 1 P53 tetramerisation motif SAM_2 PF07647.15 T256920_1 - 8.9e-10 38.4 0.0 1.6e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4592 PF15262.4 T195070_1 - 1.2e-10 42.2 0.1 3.2e-10 40.8 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4592) DUF4592 PF15262.4 T195070_2 - 2.4e-15 57.4 2.2 2.4e-15 57.4 2.2 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4592) DUF2735 PF10931.6 T195070_3 - 8.3 7.0 6.9 1.3 9.6 0.1 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2735) BTG PF07742.10 T083977_2 - 4.8e-42 142.4 0.0 6.9e-42 141.8 0.0 1.2 1 0 0 1 1 1 1 BTG family eIF_4EBP PF05456.9 T290099_1 - 2.2e-20 72.6 0.1 4.5e-20 71.6 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Ank_2 PF12796.5 T290099_3 - 9.8e-150 487.4 36.5 4.2e-19 68.8 0.6 12.2 3 3 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T290099_3 - 3.9e-119 387.5 17.3 9.5e-10 38.7 0.1 15.9 8 3 7 17 17 17 16 Ankyrin repeats (many copies) Ank PF00023.28 T290099_3 - 1e-111 360.8 50.9 5.2e-08 32.9 0.0 24.6 24 0 0 24 24 24 21 Ankyrin repeat Ank_3 PF13606.4 T290099_3 - 5.9e-102 321.1 28.8 6.7e-05 22.9 0.0 25.5 25 0 0 25 25 25 21 Ankyrin repeat Ank_5 PF13857.4 T290099_3 - 1.9e-97 317.5 46.2 5.6e-08 32.8 0.0 20.8 6 4 15 21 21 21 20 Ankyrin repeats (many copies) KH_1 PF00013.27 T290099_3 - 1.2e-14 53.7 0.6 3e-14 52.4 0.6 1.7 1 0 0 1 1 1 1 KH domain DUF4746 PF15928.3 T290099_3 - 0.092 12.0 11.1 0.18 11.1 11.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NARP1 PF12569.6 T290099_3 - 2.4 6.8 18.2 3.8 6.2 18.2 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CobT PF06213.10 T290099_3 - 4.1 6.6 19.1 8.6 5.5 19.1 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF1168 PF06658.10 T290099_3 - 9.3 5.9 28.1 31 4.2 28.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) ATG16 PF08614.9 T063573_1 - 3.5e-18 66.4 17.1 5.7e-18 65.7 17.1 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Ribosomal_L37e PF01907.17 T063573_1 - 0.14 12.2 2.9 0.37 10.8 2.9 1.7 1 0 0 1 1 1 0 Ribosomal protein L37e IncA PF04156.12 T063573_1 - 5.6 6.6 12.2 10 5.8 12.2 1.3 1 0 0 1 1 1 0 IncA protein WD40 PF00400.30 T063573_2 - 6e-22 77.4 12.4 5.7e-05 23.7 0.0 8.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T063573_2 - 0.03 14.5 0.1 22 5.3 0.0 3.6 1 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain ATG16 PF08614.9 T063573_3 - 1.3e-13 51.4 0.0 1.8e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) LAT2 PF15703.3 T326455_3 - 1.5e-74 249.5 5.7 3.4e-54 183.3 0.2 2.2 2 0 0 2 2 2 2 Linker for activation of T-cells family member 2 SSTK-IP PF15836.3 T022424_3 - 4.7e-68 226.9 6.3 6.7e-68 226.4 6.3 1.2 1 0 0 1 1 1 1 SSTK-interacting protein, TSSK6-activating co-chaperone protein DUF1725 PF08333.9 T168006_2 - 4.1e-07 29.4 1.3 8.4e-07 28.4 1.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) MORN PF02493.18 T241689_1 - 6.2e-08 32.0 0.2 0.0027 17.4 0.2 4.0 3 0 0 3 3 3 3 MORN repeat VPS9 PF02204.16 T241689_2 - 8e-09 35.5 0.0 1.3e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain VPS9 PF02204.16 T241689_3 - 0.0073 16.4 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Adenylsucc_synt PF00709.19 T111506_3 - 4.7e-178 592.3 0.0 8.7e-178 591.4 0.0 1.4 1 0 0 1 1 1 1 Adenylosuccinate synthetase Siva PF05458.10 T111506_3 - 8.5e-91 302.2 10.5 8.5e-91 302.2 10.5 2.1 2 0 0 2 2 2 1 Cd27 binding protein (Siva) FH2 PF02181.21 T111506_3 - 1.9e-73 247.6 5.6 2.7e-73 247.1 5.6 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_FH3 PF06367.14 T111506_3 - 2.2e-37 128.4 0.4 5.1e-37 127.3 0.4 1.6 1 0 0 1 1 1 1 Diaphanous FH3 Domain Drf_GBD PF06371.11 T111506_3 - 3.7e-16 59.1 0.0 6.3e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain WH2 PF02205.18 T111506_3 - 0.00013 21.5 0.2 0.00033 20.2 0.2 1.7 1 0 0 1 1 1 1 WH2 motif ASC PF00858.22 T145616_2 - 1.5e-22 80.0 0.0 2.1e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel FAM27 PF15832.3 T145616_3 - 1.2 9.6 18.5 2.6 8.5 18.5 1.5 1 0 0 1 1 1 0 FAM27 D and E protein family FAM25 PF15825.3 T041099_3 - 6.1e-05 23.1 3.3 7.8e-05 22.8 3.3 1.1 1 0 0 1 1 1 1 FAM25 family NIF PF03031.16 T080784_1 - 4.9e-50 169.2 0.0 6.8e-50 168.7 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Gelsolin PF00626.20 T080784_2 - 3.2e-54 180.6 0.1 2.2e-17 62.6 0.0 4.3 4 0 0 4 4 4 4 Gelsolin repeat Gelsolin PF00626.20 T080784_3 - 2e-29 101.2 0.3 7.7e-13 48.0 0.0 3.4 3 0 0 3 3 3 3 Gelsolin repeat VHP PF02209.17 T080784_3 - 1.3e-15 57.0 0.1 2.4e-15 56.1 0.1 1.5 1 0 0 1 1 1 1 Villin headpiece domain RasGEF PF00617.17 T120397_2 - 1e-54 185.2 0.3 2.9e-54 183.7 0.3 1.9 1 0 0 1 1 1 1 RasGEF domain RhoGEF PF00621.18 T120397_2 - 1.6e-32 113.1 4.5 4.3e-32 111.7 4.5 1.8 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 T120397_2 - 9.7e-25 87.0 0.0 7.6e-16 58.4 0.1 2.5 2 0 0 2 2 2 2 PH domain RasGEF_N PF00618.18 T120397_2 - 2.2e-22 79.1 1.1 3.1e-16 59.4 0.1 3.2 3 0 0 3 3 3 2 RasGEF N-terminal motif GOLGA2L5 PF15070.4 T120397_2 - 0.0013 17.4 2.7 0.0013 17.4 2.7 1.5 2 0 0 2 2 2 1 Putative golgin subfamily A member 2-like protein 5 IQ PF00612.25 T120397_2 - 0.014 15.0 1.6 0.057 13.1 1.6 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif PH_13 PF16652.3 T120397_2 - 0.016 15.0 0.1 0.066 13.0 0.1 2.1 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.4 T120397_2 - 0.032 14.5 0.9 0.41 11.0 0.9 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain DUF641 PF04859.10 T120397_2 - 0.88 9.8 5.1 0.65 10.2 2.4 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) ADIP PF11559.6 T120397_2 - 1.2 9.0 7.4 0.97 9.4 3.1 2.7 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Sec34 PF04136.13 T120397_2 - 2.1 8.1 5.7 0.6 9.9 0.2 2.4 2 0 0 2 2 2 0 Sec34-like family zf-H2C2_2 PF13465.4 T323834_1 - 4.1e-10 39.5 26.4 1.3e-05 25.3 0.2 5.0 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.24 T323834_1 - 0.00011 22.4 0.4 0.00011 22.4 0.4 6.8 7 0 0 7 7 7 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T323834_1 - 0.00067 20.1 28.9 0.0024 18.4 0.4 6.8 5 0 0 5 5 5 2 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T323834_1 - 0.063 12.9 0.1 0.063 12.9 0.1 3.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Collagen PF01391.16 T323834_1 - 1 9.0 7.1 3.8 7.2 7.1 2.0 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) zf-met PF12874.5 T323834_1 - 9.1 6.7 16.3 0.67 10.3 0.1 4.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Dynein_heavy PF03028.13 T141114_1 - 1.4e-262 872.9 0.1 5.3e-261 867.7 0.0 3.0 3 0 0 3 3 3 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.11 T141114_1 - 4.7e-140 467.1 14.1 4.7e-140 467.1 14.1 3.1 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 T141114_1 - 1e-99 332.8 0.0 1.9e-98 328.7 0.0 2.3 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.5 T141114_1 - 3.4e-88 294.3 0.2 1.1e-87 292.6 0.2 2.0 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 T141114_1 - 3.5e-65 219.7 0.1 9.2e-65 218.3 0.0 1.8 2 0 0 2 2 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 T141114_1 - 9.3e-58 195.5 0.1 1.5e-57 194.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.5 T141114_1 - 9.2e-49 166.2 2.5 1.5e-48 165.5 2.5 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 T141114_1 - 9.8e-34 116.2 0.0 5e-19 68.5 0.0 5.0 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA PF00004.27 T141114_1 - 1.7e-11 44.5 0.5 0.00012 22.4 0.0 4.4 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 T141114_1 - 9.2e-09 35.6 0.2 0.016 15.3 0.0 4.6 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.4 T141114_1 - 2.5e-07 31.1 0.0 0.02 15.1 0.0 4.9 4 0 0 4 4 4 1 AAA ATPase domain AAA_18 PF13238.4 T141114_1 - 6.7e-05 23.3 0.0 7.9 6.9 0.0 4.6 4 0 0 4 4 4 0 AAA domain TsaE PF02367.15 T141114_1 - 0.00017 21.5 0.1 1.2 9.0 0.0 3.5 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.18 T141114_1 - 0.00029 19.8 0.1 0.067 12.1 0.0 2.9 3 0 0 3 3 3 1 Type II/IV secretion system protein Mg_chelatase PF01078.19 T141114_1 - 0.0014 17.9 0.1 0.52 9.5 0.0 3.8 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.24 T141114_1 - 0.0022 17.6 0.0 0.042 13.4 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.4 T141114_1 - 0.0086 16.1 0.5 1.9 8.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.4 T141114_1 - 0.014 15.0 0.7 7.3 6.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF3452 PF11934.6 T141114_1 - 0.028 13.8 0.1 0.21 11.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) AAA_2 PF07724.12 T141114_1 - 0.046 13.7 0.0 0.17 11.8 0.0 1.9 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.15 T141114_1 - 0.063 12.9 0.0 0.31 10.6 0.0 2.2 2 0 0 2 2 1 0 IstB-like ATP binding protein CbiA PF01656.21 T141114_1 - 0.078 12.9 0.0 0.48 10.3 0.0 2.3 2 0 0 2 2 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ResIII PF04851.13 T141114_1 - 0.085 12.7 0.0 3.9 7.3 0.0 2.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_25 PF13481.4 T141114_1 - 0.088 12.2 0.7 6.9 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.11 T141114_1 - 0.088 11.8 0.0 0.99 8.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Guanylate_kin PF00625.19 T141114_1 - 0.11 12.1 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 Guanylate kinase Sigma54_activ_2 PF14532.4 T141114_1 - 0.15 12.1 0.0 0.46 10.5 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain ATP_bind_1 PF03029.15 T141114_1 - 0.25 11.0 2.7 0.32 10.6 0.1 2.6 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein DUF4358 PF14270.4 T141114_1 - 0.45 10.7 1.5 2.7 8.2 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) DUF4201 PF13870.4 T141114_1 - 0.5 9.8 23.9 1.1 8.7 7.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) AAA_19 PF13245.4 T141114_1 - 0.69 10.1 2.1 9 6.5 0.0 3.2 3 0 0 3 3 3 0 AAA domain JmjC PF02373.20 T141114_2 - 2.7e-31 108.2 1.6 5.2e-31 107.3 1.6 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase DHC_N1 PF08385.10 T141114_3 - 3.1e-67 227.3 0.0 4.6e-67 226.8 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 E1-E2_ATPase PF00122.18 T139875_1 - 7.3e-65 218.2 1.2 7.3e-65 218.2 1.2 2.2 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 T139875_1 - 3.5e-46 157.1 4.5 7.1e-46 156.1 4.5 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 T139875_1 - 1.3e-20 73.2 0.1 2e-20 72.5 0.1 1.3 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 T139875_1 - 9.2e-20 71.7 0.2 1.2e-18 68.1 0.2 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 T139875_1 - 4.4e-18 64.6 0.9 7.4e-18 63.9 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 T139875_1 - 3.1e-06 27.0 1.1 3.1e-06 27.0 1.1 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 T139875_1 - 0.001 19.4 0.1 0.0029 17.9 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3106 PF11304.6 T139875_1 - 0.022 15.1 0.0 0.16 12.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) zf-H2C2_2 PF13465.4 T329399_2 - 9.2e-65 212.2 46.7 7.3e-08 32.4 0.1 10.1 9 0 0 9 9 9 9 Zinc-finger double domain zf-C2H2 PF00096.24 T329399_2 - 3.2e-40 134.2 66.9 5.6e-06 26.4 0.8 10.6 10 0 0 10 10 10 8 Zinc finger, C2H2 type KRAB PF01352.25 T329399_2 - 4.1e-23 80.6 0.2 7.8e-23 79.7 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T329399_2 - 3.7e-21 73.8 53.0 0.038 14.7 1.3 9.5 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T329399_2 - 1.1e-11 44.2 40.3 0.0078 16.0 0.4 8.8 8 0 0 8 8 8 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T329399_2 - 0.0004 20.3 44.7 0.0039 17.1 1.6 6.0 2 1 5 8 8 8 6 Zinc ribbon domain XPA_N PF01286.16 T329399_2 - 0.061 13.2 35.1 7.7 6.5 0.2 8.4 8 0 0 8 8 8 0 XPA protein N-terminal zf-C2H2_11 PF16622.3 T329399_2 - 0.52 10.0 35.0 5.6 6.7 0.2 8.2 7 0 0 7 7 7 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 T329399_2 - 1 10.0 26.5 2.1 9.0 1.4 4.9 1 1 3 4 4 4 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 T329399_2 - 2.8 8.2 26.3 0.64 10.3 0.4 7.1 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding OLF PF02191.14 T368617_1 - 4.7e-87 291.5 5.5 6.6e-87 291.1 5.5 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.6 T368617_1 - 9.2e-48 160.2 10.3 2.6e-47 158.8 5.3 2.6 3 0 0 3 3 2 1 Neurogenesis glycoprotein EzrA PF06160.10 T368617_1 - 0.00077 17.6 5.7 0.0012 17.0 5.7 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Helo_like_N PF17111.3 T368617_1 - 0.0021 17.3 0.3 0.0021 17.3 0.3 2.3 1 1 1 2 2 2 1 Fungal N-terminal domain of STAND proteins APG17 PF04108.10 T368617_1 - 0.0032 16.5 4.6 0.0052 15.8 4.6 1.2 1 0 0 1 1 1 1 Autophagy protein Apg17 zf-C4H2 PF10146.7 T368617_1 - 0.0055 16.9 0.5 0.0085 16.3 0.5 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein Baculo_PEP_C PF04513.10 T368617_1 - 0.018 14.9 1.2 0.13 12.2 0.9 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-Q PF13094.4 T368617_1 - 0.032 14.3 8.1 0.058 13.4 8.1 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Lipoprotein_7 PF01540.14 T368617_1 - 0.041 13.0 1.8 0.06 12.5 1.8 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein Reo_sigmaC PF04582.10 T368617_1 - 0.089 12.0 0.2 0.13 11.4 0.2 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein IncA PF04156.12 T368617_1 - 0.13 11.9 15.8 0.36 10.5 16.0 1.6 1 1 0 1 1 1 0 IncA protein DUF4795 PF16043.3 T368617_1 - 0.35 10.3 11.0 1 8.8 10.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) NPV_P10 PF05531.10 T368617_1 - 0.44 10.9 3.2 6.6 7.1 2.4 2.8 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.7 T368617_1 - 0.46 10.7 10.9 1.6 8.9 0.7 3.1 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.10 T368617_1 - 0.77 9.6 9.3 5.4 6.9 4.9 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Nup54 PF13874.4 T368617_1 - 0.92 9.5 8.1 2.2 8.2 8.1 1.7 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Syntaxin_2 PF14523.4 T368617_1 - 0.93 9.8 9.4 16 5.8 9.4 2.3 1 1 0 1 1 1 0 Syntaxin-like protein Exonuc_VII_L PF02601.13 T368617_1 - 1.1 8.6 6.7 1.7 8.0 6.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CLZ PF16526.3 T368617_1 - 2.2 8.6 13.0 2.2 8.5 4.3 2.9 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels H-kinase_dim PF02895.12 T368617_1 - 2.5 8.4 5.7 33 4.8 5.7 2.4 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain Laminin_II PF06009.10 T368617_1 - 2.5 8.0 7.0 1 9.2 3.0 2.1 1 1 1 2 2 2 0 Laminin Domain II TBCC_N PF16752.3 T368617_1 - 2.7 8.3 11.3 1.4 9.3 7.7 2.1 1 1 2 3 3 3 0 Tubulin-specific chaperone C N-terminal domain CorA PF01544.16 T368617_1 - 4.2 6.5 5.2 6.3 5.9 5.2 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein HSBP1 PF06825.10 T368617_1 - 5.7 6.8 6.1 53 3.7 0.4 3.4 3 0 0 3 3 3 0 Heat shock factor binding protein 1 AAA_23 PF13476.4 T368617_1 - 8.9 6.6 6.5 20 5.5 6.5 1.6 1 0 0 1 1 1 0 AAA domain WD40 PF00400.30 T198677_3 - 3.5e-08 33.8 5.5 0.00028 21.5 0.9 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T198677_3 - 0.073 13.2 0.0 1 9.6 0.0 2.4 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ion_trans_2 PF07885.14 T049210_3 - 4.5e-31 106.5 19.6 1.1e-17 63.6 4.4 2.3 2 0 0 2 2 2 2 Ion channel BEN PF10523.7 T010777_3 - 2.6e-14 53.0 0.1 5.6e-14 52.0 0.1 1.6 1 0 0 1 1 1 1 BEN domain T4SS PF07996.9 T010777_3 - 0.012 15.9 0.1 0.02 15.2 0.1 1.3 1 0 0 1 1 1 0 Type IV secretion system proteins Peptidase_M14 PF00246.22 T010777_3 - 0.12 12.0 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 Zinc carboxypeptidase Sec8_exocyst PF04048.12 T010777_3 - 0.14 11.9 2.1 0.26 11.1 2.1 1.3 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain OmpH PF03938.12 T010777_3 - 0.2 11.5 4.1 0.49 10.2 4.1 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Resistin PF06954.9 T010777_3 - 0.32 11.4 10.1 1.6 9.2 10.0 2.3 2 0 0 2 2 2 0 Resistin DASH_Spc34 PF08657.8 T010777_3 - 0.34 10.6 2.4 0.57 9.9 2.4 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 TSNAXIP1_N PF15739.3 T010777_3 - 0.48 10.7 7.5 1.3 9.3 7.5 1.7 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus DAN PF03045.13 T169113_3 - 4.1e-12 45.9 1.7 7.5e-12 45.1 1.7 1.4 1 0 0 1 1 1 1 DAN domain WhiA_N PF10298.7 T059097_2 - 0.068 13.1 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 WhiA N-terminal LAGLIDADG-like domain Gly_acyl_tr_N PF06021.9 T059097_3 - 7.2e-89 297.1 1.0 1e-88 296.6 1.0 1.2 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.8 T059097_3 - 2.8e-44 149.2 0.5 6e-44 148.1 0.5 1.6 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region Transposase_22 PF02994.12 T059097_3 - 8.6e-34 116.8 0.2 1.1e-33 116.5 0.2 1.1 1 0 0 1 1 1 1 L1 transposable element DUF1151 PF06625.9 T244208_3 - 8.8e-39 131.8 17.3 1.3e-38 131.3 17.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1151) KIAA1328 PF15369.4 T244208_3 - 0.75 9.4 9.6 1.2 8.8 9.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Peptidase_M10 PF00413.22 T066519_3 - 2.6e-61 205.9 0.0 3.8e-61 205.4 0.0 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 T066519_3 - 1.5e-45 152.7 18.3 1.4e-14 53.6 1.7 4.6 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 T066519_3 - 5.2e-10 39.3 0.0 9.6e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.4 T066519_3 - 0.0065 16.8 0.0 0.013 15.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T066519_3 - 0.041 13.4 0.2 0.064 12.7 0.2 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 T066519_3 - 0.044 13.8 0.1 0.07 13.1 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4953 PF16313.3 T066519_3 - 0.18 10.8 0.1 0.28 10.2 0.1 1.1 1 0 0 1 1 1 0 Met-zincin Gtr1_RagA PF04670.10 T307914_1 - 7.4e-71 238.0 1.2 1e-70 237.6 1.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.19 T307914_1 - 4.6e-06 26.1 0.0 7e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 T307914_1 - 0.00019 20.8 0.0 0.00029 20.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 T307914_1 - 0.00039 20.5 0.0 0.00067 19.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 T307914_1 - 0.048 13.1 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 Ras family SPATA6 PF14909.4 T355159_1 - 3.1e-41 140.7 0.0 3.3e-40 137.3 0.0 2.1 1 1 0 1 1 1 1 Spermatogenesis-assoc protein 6 Trypsin PF00089.24 T357420_2 - 3.4e-79 265.6 0.7 4.2e-79 265.3 0.7 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 T357420_2 - 0.08 13.2 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) CCDC66 PF15236.4 T345409_1 - 1.8e-06 27.8 38.6 1.8e-06 27.8 38.6 6.4 7 0 0 7 7 7 2 Coiled-coil domain-containing protein 66 Merozoite_SPAM PF07133.9 T345409_1 - 2.6 7.9 35.8 0.16 11.8 22.4 3.0 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) SMC_hinge PF06470.11 T235184_1 - 7.3e-20 71.3 0.0 2.4e-19 69.6 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.17 T235184_1 - 2.4e-17 63.0 36.6 6.8e-17 61.5 36.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.4 T235184_1 - 3.2e-09 36.8 13.3 3.2e-09 36.8 13.3 4.6 2 2 3 5 5 5 1 AAA ATPase domain AAA_21 PF13304.4 T235184_1 - 3.6e-07 30.1 0.5 3.6e-07 30.1 0.5 3.1 3 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 T235184_1 - 6.9e-06 25.6 0.0 1.4e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.12 T235184_1 - 0.11 12.4 0.9 3.2 7.6 0.0 3.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.25 T235184_1 - 0.49 10.8 0.0 0.49 10.8 0.0 6.1 4 2 1 5 5 5 0 ABC transporter Myotub-related PF06602.12 T020345_1 - 1.3e-54 185.3 0.0 6.6e-42 143.5 0.0 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain OTU PF02338.17 T020345_1 - 5e-24 85.1 0.0 8.1e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease 3-PAP PF12578.6 T020345_1 - 6.1e-22 77.6 0.3 1.1e-21 76.8 0.3 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein zf-A20 PF01754.14 T020345_1 - 1.4e-05 24.8 12.2 5.6e-05 22.9 12.2 2.2 1 0 0 1 1 1 1 A20-like zinc finger UBA_4 PF14555.4 T020345_1 - 0.00029 20.4 0.0 0.00055 19.6 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.11 T020345_1 - 0.0013 18.1 0.1 0.0042 16.5 0.0 1.9 2 0 0 2 2 2 1 TAP C-terminal domain RRM_1 PF00076.20 T020345_2 - 5.6e-37 125.3 0.0 1.5e-18 66.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T020345_2 - 0.00023 21.1 0.0 0.019 14.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif SNARE_assoc PF09335.9 T054628_2 - 3.4e-21 75.8 6.2 3.4e-21 75.8 6.2 2.5 3 0 0 3 3 3 1 SNARE associated Golgi protein Aldedh PF00171.20 T143690_2 - 1.3e-84 284.2 0.0 1.8e-84 283.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.12 T143690_2 - 0.002 17.1 0.0 0.0033 16.4 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) PT-HINT PF07591.9 T143690_2 - 0.17 12.0 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 Pretoxin HINT domain Collagen PF01391.16 T269384_2 - 5.1e-72 237.4 296.2 1.9e-09 37.0 26.3 9.4 3 2 6 9 9 9 9 Collagen triple helix repeat (20 copies) MAGE_N PF12440.6 T269384_3 - 0.37 11.4 1.2 0.64 10.6 1.2 1.4 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal Integrase_AP2 PF14657.4 T269384_3 - 3 7.5 5.9 5.6 6.7 5.9 1.4 1 0 0 1 1 1 0 AP2-like DNA-binding integrase domain C2 PF00168.28 T059774_3 - 7.3e-52 173.8 1.8 1.1e-25 89.8 0.1 2.3 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.4 T059774_3 - 0.14 11.6 0.0 0.34 10.3 0.0 1.6 2 0 0 2 2 2 0 CEP76 C2 domain Kinesin PF00225.21 T315701_3 - 2.4e-70 237.0 0.0 2e-69 234.0 0.0 1.9 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 T315701_3 - 6.3e-21 74.8 0.0 1.1e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding zf-H2C2_2 PF13465.4 T354482_1 - 1.6e-200 641.3 188.1 5.1e-08 32.9 0.8 31.5 31 0 0 31 31 31 28 Zinc-finger double domain zf-C2H2 PF00096.24 T354482_1 - 3.2e-138 442.9 225.7 3.7e-06 27.0 0.4 31.7 31 0 0 31 31 31 29 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T354482_1 - 2.3e-58 189.6 219.4 0.017 15.8 0.4 31.4 30 0 0 30 30 30 28 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T354482_1 - 7.7e-22 77.0 129.1 0.014 15.3 1.9 17.8 9 4 10 20 20 20 18 Zinc ribbon domain zf-C2H2_6 PF13912.4 T354482_1 - 2.1e-21 75.2 177.9 0.011 15.6 1.0 28.1 30 0 0 30 30 30 19 C2H2-type zinc finger KRAB PF01352.25 T354482_1 - 1.7e-18 65.9 0.1 3.3e-18 64.9 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 T354482_1 - 2.4e-07 30.7 115.6 0.3 11.3 0.1 26.3 29 0 0 29 29 29 6 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T354482_1 - 8.3e-05 23.1 108.8 2.4 8.8 4.4 14.7 2 2 13 16 16 16 7 zinc-ribbon family XPA_N PF01286.16 T354482_1 - 0.18 11.8 111.7 13 5.8 0.0 27.4 30 0 0 30 30 30 0 XPA protein N-terminal COMM_domain PF07258.12 T354482_2 - 3.3e-14 52.6 0.0 7.3e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 COMM domain Transposase_22 PF02994.12 T032171_1 - 1.7e-05 23.7 0.0 2.5e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 L1 transposable element Pkinase PF00069.23 T358098_3 - 2.9e-35 121.8 0.5 7e-30 104.1 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 T358098_3 - 4.1e-15 55.6 0.1 3.8e-12 45.9 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase KA1 PF02149.17 T358098_3 - 7.3e-14 51.2 0.2 1.6e-13 50.1 0.2 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.4 T358098_3 - 0.0064 15.7 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like GYF PF02213.14 T209806_1 - 7.6e-21 73.5 0.4 1.9e-20 72.2 0.4 1.7 1 0 0 1 1 1 1 GYF domain DUF4339 PF14237.4 T209806_1 - 0.002 17.8 0.1 0.0068 16.1 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4339) PRTase_3 PF15610.4 T209806_1 - 0.097 11.8 0.2 0.21 10.6 0.2 1.5 1 0 0 1 1 1 0 PRTase ComF-like DUF4690 PF15756.3 T209806_3 - 3.4e-42 142.8 0.6 7.9e-42 141.7 0.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4690) HEAT PF02985.20 T353541_1 - 0.052 13.7 0.8 28 5.2 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat EF1_GNE PF00736.17 T353541_2 - 3.7e-35 119.8 0.4 5.7e-35 119.2 0.4 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 T353541_2 - 1.1e-11 44.8 7.6 1.1e-11 44.8 7.6 2.0 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region NAPRTase PF04095.14 T353541_2 - 0.0084 15.6 0.0 0.029 13.9 0.0 1.7 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) family Striatin PF08232.10 T353541_2 - 0.048 14.1 1.7 0.081 13.4 1.7 1.2 1 0 0 1 1 1 0 Striatin family JIP_LZII PF16471.3 T353541_2 - 0.21 11.6 0.5 0.36 10.9 0.5 1.3 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II MFS_1 PF07690.14 T060383_2 - 1.1e-12 47.4 13.6 3.6e-12 45.7 8.1 2.2 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.22 T060383_2 - 1.7e-11 43.6 6.6 2.4e-11 43.1 6.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter DUF1725 PF08333.9 T060383_3 - 0.08 12.5 0.3 0.16 11.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) CTNNB1_binding PF08347.9 T269258_3 - 7.1e-53 179.7 6.8 7.1e-53 179.7 6.8 2.0 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 T269258_3 - 2.1e-21 76.0 0.7 2.1e-21 76.0 0.7 2.5 4 0 0 4 4 4 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T269258_3 - 5.7e-08 33.1 3.0 6.8e-08 32.9 0.8 2.2 2 0 0 2 2 2 1 HMG-box domain Bac_DnaA_C PF08299.9 T180154_1 - 0.021 14.7 4.4 11 6.0 0.0 5.4 3 2 5 8 8 8 0 Bacterial dnaA protein helix-turn-helix Baculo_LEF-11 PF06385.10 T180154_1 - 0.19 12.1 8.7 2.8 8.4 0.8 4.0 4 0 0 4 4 4 0 Baculovirus LEF-11 protein zf-H2C2_2 PF13465.4 T180154_3 - 6.7e-111 358.1 118.4 1.5e-08 34.6 2.3 18.1 18 0 0 18 18 18 15 Zinc-finger double domain zf-C2H2 PF00096.24 T180154_3 - 4.3e-83 269.3 130.9 3.7e-07 30.1 1.2 17.5 17 0 0 17 17 17 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T180154_3 - 5.3e-44 144.9 122.6 0.00068 20.1 0.8 17.4 17 0 0 17 17 17 15 C2H2-type zinc finger KRAB PF01352.25 T180154_3 - 3.9e-25 87.1 0.1 7.1e-25 86.3 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T180154_3 - 1.3e-15 56.7 117.1 0.027 14.3 1.0 18.3 16 4 0 16 16 16 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T180154_3 - 1.1e-14 54.1 80.4 0.022 14.7 1.3 13.7 5 3 11 16 16 16 11 Zinc ribbon domain C1_1 PF00130.20 T180154_3 - 2.4e-08 33.6 52.5 0.2 11.4 0.7 11.0 4 2 6 10 10 10 5 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_jaz PF12171.6 T180154_3 - 3.5e-08 33.4 81.8 0.66 10.2 0.2 16.2 16 0 0 16 16 16 6 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T180154_3 - 5e-08 32.4 86.5 0.04 13.6 0.1 15.3 15 0 0 15 15 15 7 zinc-finger C2H2-type FAM178 PF14816.4 T180154_3 - 1.2e-07 30.9 10.6 3 6.6 0.0 9.0 3 2 7 11 11 11 1 Family of unknown function, FAM178 zinc_ribbon_15 PF17032.3 T180154_3 - 3e-07 31.0 66.1 0.14 12.8 1.6 8.6 1 1 7 9 9 9 6 zinc-ribbon family DZR PF12773.5 T180154_3 - 3.4e-05 23.7 60.4 5.3 7.0 0.1 8.9 2 1 0 2 2 1 1 Double zinc ribbon XPA_N PF01286.16 T180154_3 - 0.0056 16.6 55.9 27 4.8 0.9 14.7 16 0 0 16 16 16 0 XPA protein N-terminal MRP-S23 PF10484.7 T180154_3 - 0.0062 16.7 0.0 94 3.1 0.0 6.3 6 2 4 10 10 9 0 Mitochondrial ribosomal protein S23 TFIIS_C PF01096.16 T180154_3 - 0.0069 16.1 67.2 5.7 6.7 0.5 14.4 14 0 0 14 14 14 2 Transcription factor S-II (TFIIS) zf-LYAR PF08790.9 T180154_3 - 0.021 14.6 73.1 0.26 11.1 1.4 15.3 16 0 0 16 16 16 0 LYAR-type C2HC zinc finger BolA PF01722.16 T180154_3 - 0.036 14.2 33.0 0.64 10.2 0.6 7.6 3 2 4 7 7 7 0 BolA-like protein Arc_trans_TRASH PF08394.8 T180154_3 - 0.16 12.2 30.8 14 6.0 0.0 10.6 11 3 2 13 13 13 0 Archaeal TRASH domain zf-Di19 PF05605.10 T192860_2 - 6.9e-22 77.3 1.6 1.6e-21 76.2 1.6 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding ZZ PF00569.15 T192860_2 - 1.9e-10 40.2 6.5 6.4e-10 38.5 6.5 2.0 1 0 0 1 1 1 1 Zinc finger, ZZ type Di19_C PF14571.4 T192860_2 - 0.11 12.9 5.2 0.12 12.8 3.9 1.8 1 1 0 1 1 1 0 Stress-induced protein Di19, C-terminal STAS PF01740.19 T330946_2 - 2.2e-42 143.2 0.7 4.1e-42 142.4 0.3 1.7 2 0 0 2 2 2 1 STAS domain Sulfate_transp PF00916.18 T330946_2 - 9.2e-13 47.5 1.5 1.3e-12 47.1 1.5 1.2 1 0 0 1 1 1 1 Sulfate permease family HALZ PF02183.16 T315421_3 - 0.29 11.3 5.2 0.072 13.2 1.0 2.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF4527 PF15030.4 T315421_3 - 1.8 7.9 7.2 2.7 7.3 7.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) ACOX PF01756.17 T154680_1 - 4.5e-61 205.4 1.6 6.9e-61 204.8 1.6 1.2 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.4 T154680_1 - 3.7e-35 121.1 0.1 5.6e-35 120.5 0.1 1.3 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.17 T154680_1 - 1.2e-10 41.3 0.0 2.1e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain PBP PF01161.18 T154680_3 - 5.9e-08 33.0 0.0 1.2e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein RHD_dimer PF16179.3 T219958_1 - 5.9e-25 87.2 0.4 9.4e-25 86.5 0.4 1.3 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.20 T219958_1 - 6e-22 78.2 0.4 1.1e-21 77.3 0.4 1.5 1 1 0 1 1 1 1 Rel homology DNA-binding domain TIG PF01833.22 T219958_1 - 1.9e-06 27.7 0.0 4.1e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 IPT/TIG domain DUF1725 PF08333.9 T140631_2 - 2.7e-17 61.7 8.4 8.3e-09 34.7 1.8 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF1725) HERV-K_REC PF15695.3 T140631_2 - 4.4e-06 26.5 1.8 7.6e-06 25.8 1.8 1.3 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 HERV-K_env_2 PF13804.4 T140631_2 - 0.00053 19.6 0.1 0.00091 18.9 0.1 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Integrase_Zn PF02022.17 T140631_2 - 0.02 14.7 0.0 0.02 14.7 0.0 2.0 2 0 0 2 2 2 0 Integrase Zinc binding domain RNase_H PF00075.22 T140631_3 - 1.6e-07 31.5 0.2 2.7e-07 30.7 0.2 1.3 1 0 0 1 1 1 1 RNase H IN_DBD_C PF00552.19 T140631_3 - 7.4e-05 21.8 0.1 0.00016 20.8 0.1 1.5 1 0 0 1 1 1 1 Integrase DNA binding domain Pkinase PF00069.23 T146760_3 - 3.6e-73 246.0 0.0 5.3e-73 245.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T146760_3 - 3.2e-33 115.0 0.0 5e-33 114.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T146760_3 - 0.0028 16.9 0.0 0.01 15.0 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Glyco_transf_49 PF13896.4 T061602_1 - 2.4e-101 339.3 0.0 3e-101 339.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Sds3 PF08598.9 T061602_2 - 2.5e-17 63.5 0.3 4.1e-17 62.8 0.3 1.3 1 0 0 1 1 1 1 Sds3-like EBP50_C PF09007.9 T061602_2 - 4.7 8.1 7.2 12 6.8 7.2 1.6 1 0 0 1 1 1 0 EBP50, C-terminal VPS9 PF02204.16 T061602_3 - 1.5e-20 73.2 0.0 2.2e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RA PF00788.21 T061602_3 - 0.00022 21.7 0.0 0.00042 20.8 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SH2 PF00017.22 T061602_3 - 0.021 14.7 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 SH2 domain Smoothelin PF12510.6 T232222_2 - 4.7e-34 116.0 24.5 5.6e-21 74.2 2.3 3.0 3 0 0 3 3 3 2 Smoothelin cytoskeleton protein CH PF00307.29 T232222_2 - 1.8e-23 82.6 0.0 5.5e-22 77.9 0.0 2.3 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 T232222_2 - 3e-05 23.7 0.0 5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain Smoothelin PF12510.6 T232222_3 - 5.5e-13 48.6 3.9 9e-13 47.9 3.9 1.3 1 0 0 1 1 1 1 Smoothelin cytoskeleton protein DEAD PF00270.27 T156049_2 - 2.3e-42 144.6 0.2 3.7e-42 143.9 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T156049_2 - 1.4e-31 109.0 0.0 4.6e-31 107.3 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.4 T156049_2 - 0.00072 19.8 0.0 0.0055 16.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain UTP25 PF06862.10 T156049_2 - 0.019 13.6 0.0 2.2 6.8 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.4 T156049_2 - 0.13 12.4 0.0 0.61 10.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain Ion_trans PF00520.29 T142573_2 - 1e-18 67.4 15.7 1e-18 67.4 15.7 1.8 2 0 0 2 2 2 1 Ion transport protein Ank_2 PF12796.5 T142573_2 - 8e-14 51.9 0.1 8.5e-07 29.4 0.0 3.5 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T142573_2 - 4.9e-11 42.5 0.2 0.0022 18.2 0.2 3.8 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 T142573_2 - 6.5e-10 38.9 0.3 0.00012 22.2 0.1 4.5 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.4 T142573_2 - 9.7e-07 29.1 0.0 0.004 17.6 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 T142573_2 - 2.6e-06 27.2 0.4 0.045 14.2 0.1 4.5 5 0 0 5 5 5 2 Ankyrin repeat TM140 PF14985.4 T333773_3 - 8.5e-93 308.8 7.4 1.3e-92 308.2 7.4 1.2 1 0 0 1 1 1 1 TM140 protein family TMEM37 PF15108.4 T333773_3 - 0.014 15.1 1.7 0.024 14.4 1.7 1.3 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family Orai-1 PF07856.10 T330250_1 - 3.8e-70 235.0 1.0 5.5e-70 234.5 1.0 1.2 1 0 0 1 1 1 1 Mediator of CRAC channel activity Sec23_trunk PF04811.13 T103234_1 - 2e-79 266.5 0.0 2.7e-79 266.0 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.10 T103234_1 - 3.8e-33 114.0 0.0 7.3e-33 113.1 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.13 T103234_1 - 7e-27 93.1 0.1 1.6e-26 92.0 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.13 T103234_1 - 2.2e-15 56.3 6.5 4.7e-15 55.2 6.5 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 T103234_1 - 1.5e-14 53.5 0.0 3.4e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat APP_E2 PF12925.5 T103234_1 - 0.046 13.3 0.0 0.087 12.4 0.0 1.4 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein Rho_GDI PF02115.15 T156671_1 - 2.1e-79 265.6 0.3 3e-79 265.1 0.3 1.2 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Thioredoxin PF00085.18 T156671_1 - 5.7e-63 209.2 0.5 1.5e-32 111.5 0.0 3.2 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.4 T156671_1 - 2.6e-45 154.5 6.8 4.1e-40 137.6 4.5 3.0 2 1 1 3 3 3 2 Thioredoxin-like domain Ank_4 PF13637.4 T156671_1 - 2e-13 50.4 0.0 4.2e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.5 T156671_1 - 1.3e-12 48.0 0.0 2.7e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T156671_1 - 6.7e-12 45.3 0.3 1.3e-06 28.5 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Thioredoxin_2 PF13098.4 T156671_1 - 4.7e-11 43.0 0.0 5.3e-05 23.5 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like domain Ank_3 PF13606.4 T156671_1 - 6.1e-11 41.4 0.1 6.4e-05 22.9 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.28 T156671_1 - 1.2e-10 41.2 0.3 8.2e-05 22.8 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Thioredoxin_7 PF13899.4 T156671_1 - 1.1e-09 38.2 0.0 7.6e-05 22.7 0.0 2.8 3 0 0 3 3 2 2 Thioredoxin-like OST3_OST6 PF04756.11 T156671_1 - 7.3e-08 32.0 0.1 0.00019 20.8 0.0 3.1 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.19 T156671_1 - 5.4e-06 26.2 0.3 0.019 14.7 0.0 3.2 2 1 1 3 3 3 2 AhpC/TSA family Thioredoxin_8 PF13905.4 T156671_1 - 8.8e-06 25.8 0.1 0.12 12.5 0.0 3.2 3 1 0 3 3 3 2 Thioredoxin-like Calsequestrin PF01216.15 T156671_1 - 3.5e-05 22.9 1.2 6.2e-05 22.1 1.2 1.3 1 0 0 1 1 1 1 Calsequestrin Redoxin PF08534.8 T156671_1 - 0.019 14.5 0.2 2.9 7.4 0.1 2.6 2 0 0 2 2 2 0 Redoxin FAM195 PF14799.4 T156671_3 - 2.2e-19 69.6 0.0 3.8e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 FAM195 family Glyco_transf_7N PF13733.4 T357260_1 - 1.5e-58 196.1 0.1 2.2e-58 195.6 0.1 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 T357260_1 - 1.2e-28 98.4 0.1 2.1e-28 97.7 0.1 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 T357260_1 - 0.0099 15.2 0.0 0.02 14.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 zf-CCHC_2 PF13696.4 T357260_3 - 0.51 10.1 8.3 0.21 11.3 2.2 2.8 2 0 0 2 2 2 0 Zinc knuckle RRM_1 PF00076.20 T040710_2 - 3.7e-26 90.6 0.0 3e-11 42.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF PF08080.10 T040710_2 - 2.5e-22 78.4 7.9 5.9e-22 77.2 7.9 1.7 1 0 0 1 1 1 1 RNPHF zinc finger RRM_3 PF08777.9 T040710_2 - 0.0077 16.1 0.0 8.2 6.4 0.0 3.1 3 0 0 3 3 3 2 RNA binding motif ICMT PF04140.12 T002178_3 - 4e-33 113.6 0.1 7.2e-33 112.8 0.1 1.4 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.11 T002178_3 - 1.5e-06 28.4 0.5 3e-06 27.5 0.5 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase Sina PF03145.14 T252450_3 - 1.7e-85 285.9 0.2 2.3e-85 285.5 0.2 1.2 1 0 0 1 1 1 1 Seven in absentia protein family zf-C3HC4_2 PF13923.4 T252450_3 - 3.3 7.5 15.1 9.6 6.0 15.1 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) C2 PF00168.28 T170455_2 - 1.2e-54 182.8 2.7 5.6e-26 90.7 0.3 3.6 3 0 0 3 3 3 3 C2 domain Membr_traf_MHD PF10540.7 T170455_2 - 4.4e-51 172.9 3.1 8.6e-51 172.0 3.1 1.5 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain DUF1041 PF06292.15 T170455_2 - 2.2e-35 121.0 0.3 2.2e-35 121.0 0.3 2.4 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1041) C1_1 PF00130.20 T170455_2 - 8.1e-11 41.5 6.2 1.9e-10 40.3 6.2 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) APG6 PF04111.10 T170455_2 - 0.14 11.4 6.3 0.27 10.4 6.3 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 I-set PF07679.14 T043078_1 - 7.8e-105 343.0 0.0 2.9e-20 72.0 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 T043078_1 - 2.7e-74 245.6 0.1 5.3e-14 52.5 0.0 6.0 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 T043078_1 - 3.5e-48 161.6 0.2 2.6e-09 37.0 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 T043078_1 - 1.3e-47 159.9 0.6 7.4e-09 35.7 0.0 6.0 6 0 0 6 6 6 5 Immunoglobulin domain V-set PF07686.15 T043078_1 - 8.5e-17 61.2 1.6 0.035 14.1 0.0 7.5 5 3 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 T043078_1 - 7.8e-10 38.6 1.2 0.73 9.8 0.0 5.1 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 T043078_1 - 6.3e-08 32.9 0.5 0.2 12.0 0.0 5.0 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 T043078_1 - 0.002 18.0 0.0 19 5.3 0.0 3.6 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 T043078_1 - 0.0027 17.8 0.0 1.7 8.7 0.0 3.9 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 BiPBP_C PF06832.10 T043078_1 - 0.099 12.6 0.0 5.8 6.9 0.0 3.1 4 0 0 4 4 4 0 Penicillin-Binding Protein C-terminus Family UCH PF00443.27 T229585_3 - 2e-23 83.1 0.0 2e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 T229585_3 - 3.3e-16 59.7 0.2 4.7e-16 59.2 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase OATP PF03137.18 T075020_3 - 2.9e-172 573.6 20.6 3.7e-172 573.3 20.6 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 T075020_3 - 5.3e-22 78.1 28.7 1.1e-20 73.8 20.5 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.13 T075020_3 - 2.5e-13 49.8 4.0 7.9e-13 48.2 4.0 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 T075020_3 - 0.00075 19.3 3.6 0.0026 17.6 3.6 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain zf-CCHC PF00098.21 T250285_2 - 9.3e-43 142.3 73.5 9e-07 28.6 2.3 8.3 8 0 0 8 8 8 7 Zinc knuckle zf-CCHC_4 PF14392.4 T250285_2 - 8.5e-09 34.9 48.3 0.02 14.4 0.2 7.5 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.4 T250285_2 - 2.1e-06 27.2 54.9 0.0045 16.5 1.7 7.5 5 2 3 8 8 8 6 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.4 T250285_2 - 0.036 13.9 0.3 0.036 13.9 0.3 7.0 2 1 5 7 7 7 0 Zinc knuckle IP_trans PF02121.16 T088301_2 - 1.5e-112 375.1 1.4 2.1e-112 374.5 1.4 1.2 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein DDHD PF02862.15 T088301_2 - 1.7e-13 51.1 1.4 2.2e-13 50.7 0.0 1.9 2 0 0 2 2 2 1 DDHD domain Acid_phosphat_B PF03767.12 T088301_2 - 0.1 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) DDHD PF02862.15 T088301_3 - 4.1e-33 115.4 0.0 6.2e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 DDHD domain AAA_22 PF13401.4 T192170_2 - 0.00089 19.4 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 T192170_2 - 0.0062 16.8 0.2 0.015 15.6 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain OB_NTP_bind PF07717.14 T192170_2 - 0.011 15.7 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_29 PF13555.4 T192170_2 - 0.018 14.6 0.0 0.047 13.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.4 T192170_2 - 0.03 14.5 0.0 0.049 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 T192170_2 - 0.047 13.3 0.0 0.08 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain HA2 PF04408.21 T192170_3 - 1e-15 57.8 0.4 2.1e-15 56.8 0.4 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) CUE PF02845.14 T192170_3 - 7e-09 35.1 0.0 1.3e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 CUE domain CCDC142 PF14923.4 T192100_1 - 4.9e-151 503.4 1.8 7.3e-151 502.8 1.8 1.2 1 0 0 1 1 1 1 Coiled-coil protein 142 RINT1_TIP1 PF04437.11 T192100_1 - 0.091 11.5 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 RINT-1 / TIP-1 family MRP_L53 PF10780.7 T192100_2 - 1.9e-14 53.4 0.1 3.9e-14 52.4 0.1 1.6 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 p450 PF00067.20 T329246_1 - 2.1e-34 118.9 0.7 5.5e-21 74.7 0.1 3.1 3 0 0 3 3 3 3 Cytochrome P450 RVT_1 PF00078.25 T329246_1 - 8.8e-21 74.3 0.9 1.3e-20 73.7 0.9 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T329246_1 - 0.0024 17.3 2.5 0.0063 16.0 2.5 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T329246_2 - 4.9e-143 476.3 22.8 7.2e-143 475.7 22.8 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T329246_2 - 4.1e-24 85.2 0.1 6.8e-24 84.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) p450 PF00067.20 T329246_2 - 5.3e-08 31.9 0.0 8.7e-08 31.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Syntaxin-6_N PF09177.9 T329246_2 - 0.00075 19.9 7.3 0.0026 18.2 7.3 2.0 1 0 0 1 1 1 1 Syntaxin 6, N-terminal GCN5L1 PF06320.11 T329246_2 - 0.023 14.7 3.0 0.024 14.6 1.2 1.9 1 1 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) ATG16 PF08614.9 T329246_2 - 0.45 10.5 16.2 0.47 10.5 13.0 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Seryl_tRNA_N PF02403.20 T329246_2 - 7.6 6.7 18.8 0.0063 16.6 6.0 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF16 PF01519.14 T329246_2 - 8 6.9 13.3 4.6 7.6 8.1 2.8 2 1 0 2 2 2 0 Protein of unknown function DUF16 XhlA PF10779.7 T329246_2 - 9.1 6.4 10.7 0.77 9.9 2.2 2.6 2 0 0 2 2 2 0 Haemolysin XhlA Pro-rich PF15240.4 T074019_1 - 5.3e-06 26.8 1.1 5.3e-06 26.8 1.1 3.0 2 1 0 2 2 2 1 Proline-rich Pro-rich PF15240.4 T074019_2 - 2.3e-24 86.5 308.2 2.8e-12 47.2 79.7 3.4 1 1 3 4 4 4 4 Proline-rich Pro-rich PF15240.4 T074019_3 - 2.8e-06 27.7 72.7 2.8e-06 27.7 72.7 2.2 1 1 1 2 2 2 1 Proline-rich BLOC1_2 PF10046.7 T047151_1 - 1.2e-33 115.2 7.0 1.2e-33 115.2 7.0 1.5 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 PKD_channel PF08016.10 T047151_2 - 7.9e-94 314.6 24.4 1.2e-93 314.1 24.4 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.29 T047151_2 - 3.6e-27 95.0 28.1 3.6e-27 95.0 28.1 1.8 2 0 0 2 2 2 1 Ion transport protein Dynamin_M PF01031.18 T226557_2 - 1.2e-87 293.6 12.2 2.1e-87 292.9 12.2 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.21 T226557_2 - 5.7e-49 166.3 0.2 5.7e-49 166.3 0.2 1.8 2 0 0 2 2 2 1 Dynamin family GED PF02212.16 T226557_2 - 6.3e-26 90.2 1.6 1.5e-25 89.0 1.6 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 T226557_2 - 0.0013 18.7 1.2 0.007 16.3 0.3 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.4 T226557_2 - 0.068 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 T226557_2 - 0.083 12.5 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2120 PF09893.7 T226557_2 - 0.15 12.1 0.3 0.38 10.7 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) LRR_8 PF13855.4 T244812_2 - 1.8e-70 232.5 45.9 1.7e-16 59.6 5.3 7.3 3 2 3 7 7 7 7 Leucine rich repeat I-set PF07679.14 T244812_2 - 1.3e-54 182.1 0.0 3.3e-20 71.8 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 T244812_2 - 1.5e-47 160.0 0.1 4.2e-17 62.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain LRR_4 PF12799.5 T244812_2 - 4.1e-38 128.5 41.4 3e-06 27.3 0.3 9.2 5 1 6 11 11 11 11 Leucine Rich repeats (2 copies) Ig_2 PF13895.4 T244812_2 - 5.6e-37 125.8 0.1 3.8e-13 49.5 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T244812_2 - 8.8e-28 96.2 0.2 2.1e-08 34.1 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain LRR_5 PF13306.4 T244812_2 - 1e-20 73.8 0.0 6.6e-06 26.0 0.0 4.1 1 1 3 4 4 4 4 Leucine rich repeats (6 copies) V-set PF07686.15 T244812_2 - 6.5e-15 55.1 3.7 0.00041 20.3 0.2 5.3 3 3 0 3 3 3 3 Immunoglobulin V-set domain LRR_9 PF14580.4 T244812_2 - 1.5e-14 53.8 7.8 5.3e-05 22.7 0.0 4.6 1 1 4 5 5 5 4 Leucine-rich repeat C2-set_2 PF08205.10 T244812_2 - 1e-09 38.2 0.1 0.0012 18.7 0.0 3.5 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain LRRCT PF01463.22 T244812_2 - 2.4e-06 27.5 0.1 2e-05 24.7 0.1 2.8 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain Ig_5 PF16681.3 T244812_2 - 5e-06 26.7 0.0 0.21 11.9 0.0 3.8 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 T244812_2 - 0.00014 21.7 2.5 0.74 9.8 0.0 3.7 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain LRR_1 PF00560.31 T244812_2 - 0.00018 21.3 33.6 42 5.1 0.1 13.5 12 2 1 13 13 13 0 Leucine Rich Repeat C1-set PF07654.13 T244812_2 - 0.00043 20.6 0.4 0.61 10.5 0.1 3.3 3 0 0 3 3 3 1 Immunoglobulin C1-set domain LRRNT PF01462.16 T244812_2 - 0.011 15.2 1.0 0.011 15.2 1.0 4.0 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 T244812_2 - 0.11 12.5 46.3 7.1 6.8 0.1 12.8 15 0 0 15 15 14 0 Leucine Rich repeat Bromodomain PF00439.23 T209345_1 - 9.1e-07 28.7 0.1 2.1e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 Bromodomain HSR PF03172.11 T209345_2 - 1.8e-43 146.6 1.7 3e-43 145.9 1.7 1.4 1 0 0 1 1 1 1 HSR domain SAND PF01342.19 T209345_2 - 9.8e-19 66.7 0.2 2e-18 65.7 0.2 1.5 1 0 0 1 1 1 1 SAND domain PHD PF00628.27 T209345_2 - 1.6e-05 24.6 4.0 1.6e-05 24.6 4.0 3.1 3 0 0 3 3 3 1 PHD-finger DUF1725 PF08333.9 T209345_3 - 2.6e-06 26.8 0.4 5.3e-06 25.8 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) SAND PF01342.19 T209345_3 - 0.00012 21.6 0.0 0.00028 20.4 0.0 1.7 1 0 0 1 1 1 1 SAND domain BNIP2 PF12496.6 T360649_3 - 2.1e-37 128.5 3.3 3e-37 128.0 3.3 1.2 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 T360649_3 - 4.9e-33 114.0 0.1 9.8e-33 113.1 0.1 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 T360649_3 - 7.7e-08 32.1 0.1 1.7e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain Kelch_1 PF01344.23 T284349_2 - 4e-45 151.0 7.5 1.8e-10 40.1 0.1 5.6 5 0 0 5 5 5 5 Kelch motif BTB PF00651.29 T284349_2 - 1.2e-28 99.4 0.1 2.3e-28 98.5 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 T284349_2 - 2.2e-28 98.2 1.4 2.2e-28 98.2 1.4 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.4 T284349_2 - 1e-18 66.8 3.2 7.5e-05 22.7 0.0 5.6 1 1 4 5 5 5 5 Kelch motif Kelch_2 PF07646.13 T284349_2 - 4.3e-18 64.4 2.6 0.0006 19.5 0.0 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.4 T284349_2 - 6.9e-16 57.8 0.2 1.7e-06 27.7 0.0 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.4 T284349_2 - 6.8e-13 48.4 6.7 0.00021 21.3 0.0 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.4 T284349_2 - 1.3e-11 44.1 5.0 2.2e-06 27.4 0.0 4.9 4 0 0 4 4 4 2 Kelch motif DUF3342 PF11822.6 T284349_2 - 0.0027 17.7 0.0 0.0071 16.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) PFU PF09070.9 T284349_2 - 0.13 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) Trefoil PF00088.16 T226852_3 - 2.5e-14 52.7 8.7 9.4e-14 50.9 8.7 2.1 1 0 0 1 1 1 1 Trefoil (P-type) domain MORN PF02493.18 T218252_3 - 3.5e-27 92.5 62.1 9.6e-06 25.1 0.2 9.2 8 0 0 8 8 8 8 MORN repeat DUF4599 PF15371.4 T294961_3 - 0.0029 18.0 0.0 0.01 16.2 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4599) Pro_isomerase PF00160.19 T240968_1 - 9.5e-46 155.8 0.1 1.4e-45 155.3 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-C2H2 PF00096.24 T240968_3 - 7.3e-22 76.4 62.8 0.00015 21.9 1.5 10.1 9 0 0 9 9 9 8 Zinc finger, C2H2 type BTB PF00651.29 T240968_3 - 1.6e-21 76.4 0.2 2.5e-21 75.8 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 T240968_3 - 5.5e-18 64.4 59.2 2.2e-06 27.7 1.3 9.4 8 1 0 8 8 8 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 T240968_3 - 4.4e-14 51.8 61.1 0.0018 18.8 0.7 10.7 9 0 0 9 9 9 7 C2H2-type zinc finger SDA1 PF05285.10 T240968_3 - 0.45 9.8 29.5 0.72 9.1 29.5 1.2 1 0 0 1 1 1 0 SDA1 zf-met PF12874.5 T240968_3 - 0.58 10.5 46.7 0.029 14.6 0.3 8.0 8 0 0 8 8 8 0 Zinc-finger of C2H2 type Nop14 PF04147.10 T240968_3 - 0.73 7.9 29.3 1.1 7.3 29.3 1.1 1 0 0 1 1 1 0 Nop14-like family zf-C2H2_jaz PF12171.6 T240968_3 - 0.98 9.7 39.0 1.1 9.6 0.0 7.3 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T240968_3 - 2.3 8.1 45.9 0.19 11.6 0.1 8.9 8 0 0 8 8 8 0 C2H2-type zinc finger C1q PF00386.19 T157758_3 - 8.4e-11 42.0 0.0 3.1e-10 40.2 0.0 1.8 1 1 0 1 1 1 1 C1q domain Neuro_bHLH PF12533.6 T204046_1 - 8.1e-46 156.2 4.1 1.4e-45 155.4 4.1 1.4 1 0 0 1 1 1 1 Neuronal helix-loop-helix transcription factor HLH PF00010.24 T204046_1 - 1.3e-14 53.7 1.1 2.4e-14 52.9 1.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Lipocalin PF00061.21 T368773_2 - 4.3e-27 95.0 0.0 5.3e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family zf-B_box PF00643.22 T021890_1 - 1.9e-09 37.4 6.4 1.9e-09 37.4 6.4 4.1 4 1 0 4 4 4 2 B-box zinc finger zf-RING_UBOX PF13445.4 T021890_1 - 6.4e-07 29.1 2.3 6.4e-07 29.1 2.3 3.2 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 T021890_1 - 9e-07 28.5 2.4 9e-07 28.5 2.4 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T021890_1 - 1e-06 28.4 1.3 1e-06 28.4 1.3 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T021890_1 - 1.8e-05 24.3 2.8 1.8e-05 24.3 2.8 4.3 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T021890_1 - 0.00011 22.1 3.5 0.00011 22.1 3.5 3.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 T021890_1 - 0.00042 20.1 1.8 0.00042 20.1 1.8 3.8 3 1 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.4 T021890_1 - 0.0082 16.3 1.7 0.0082 16.3 1.7 4.2 4 1 0 4 4 4 1 Ring finger domain zf-piccolo PF05715.11 T021890_1 - 6.9 6.8 22.2 9.1 6.4 1.7 3.9 3 0 0 3 3 3 0 Piccolo Zn-finger fn3 PF00041.19 T021890_2 - 0.008 16.4 0.5 0.017 15.4 0.0 1.7 2 0 0 2 2 2 1 Fibronectin type III domain zf-H2C2_2 PF13465.4 T126242_1 - 1.5e-51 170.5 88.5 1.2e-09 38.0 0.6 12.1 12 0 0 12 12 12 8 Zinc-finger double domain zf-C2H2 PF00096.24 T126242_1 - 1.3e-47 157.5 93.9 5.9e-07 29.5 1.8 10.1 10 0 0 10 10 10 9 Zinc finger, C2H2 type SCAN PF02023.15 T126242_1 - 8.9e-40 134.3 2.8 1.7e-39 133.4 2.8 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2_4 PF13894.4 T126242_1 - 3.7e-26 89.4 82.5 0.0012 19.3 1.4 10.3 9 0 0 9 9 9 9 C2H2-type zinc finger KRAB PF01352.25 T126242_1 - 1.1e-12 47.3 0.1 2e-12 46.5 0.1 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 T126242_1 - 6.6e-06 26.0 38.3 0.0022 18.0 2.9 7.1 5 1 2 7 7 7 4 Zinc ribbon domain zf-C2H2_11 PF16622.3 T126242_1 - 0.00011 21.8 64.9 0.002 17.7 2.7 9.5 10 0 0 10 10 10 5 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 T126242_1 - 0.022 14.6 67.3 0.017 15.0 1.5 9.7 9 0 0 9 9 9 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T126242_1 - 0.11 13.1 30.3 0.85 10.3 0.8 5.0 3 2 2 5 5 5 0 zinc-ribbon family FYDLN_acid PF09538.8 T126242_1 - 2.1 9.0 12.6 33 5.1 0.1 6.0 3 2 5 8 8 8 0 Protein of unknown function (FYDLN_acid) Tet_JBP PF12851.5 T191960_3 - 5.2e-104 348.1 0.0 6.7e-104 347.7 0.0 1.1 1 0 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily FAM27 PF15832.3 T246830_1 - 1.3 9.5 6.0 2.5 8.6 6.0 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family Atrophin-1 PF03154.13 T246830_1 - 1.4 6.9 8.5 1.9 6.5 8.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 T246830_1 - 3.3 7.6 11.3 0.055 13.3 4.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 T246830_2 - 0.19 11.6 3.7 0.32 10.8 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 T246830_2 - 0.55 8.3 9.5 0.79 7.8 9.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family LNP1 PF15419.4 T246830_3 - 3.2e-76 255.4 21.1 3.2e-76 255.4 21.1 2.2 3 0 0 3 3 3 1 Leukemia NUP98 fusion partner 1 BES1_N PF05687.11 T246830_3 - 3.4 7.9 10.6 1.6 9.0 3.4 2.7 2 0 0 2 2 2 0 BES1/BZR1 plant transcription factor, N-terminal zf-CCCH PF00642.22 T127445_3 - 3.8e-07 29.7 24.2 2.4e-05 24.0 2.3 4.0 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C2H2_jaz PF12171.6 T127445_3 - 0.0019 18.3 8.3 0.0035 17.5 6.8 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding TPR_2 PF07719.15 T127445_3 - 0.009 15.9 0.4 2.6 8.2 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat zf-met PF12874.5 T127445_3 - 0.045 14.0 5.2 0.16 12.3 5.2 2.1 1 0 0 1 1 1 0 Zinc-finger of C2H2 type TPR_1 PF00515.26 T127445_3 - 0.22 11.2 3.5 1.6 8.5 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat UQ_con PF00179.24 T227807_2 - 4.2e-21 74.9 0.1 6.5e-21 74.3 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UQ_con PF00179.24 T227807_3 - 4.1e-16 58.8 0.0 6.5e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SSF PF00474.15 T143502_2 - 2.6e-118 395.3 18.3 2.5e-76 257.0 0.9 2.1 1 1 1 2 2 2 2 Sodium:solute symporter family DUF2700 PF10912.6 T143502_2 - 0.19 11.6 0.0 0.19 11.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2700) TSP_1 PF00090.17 T294858_1 - 5e-08 32.9 37.2 1e-06 28.7 7.4 4.3 4 0 0 4 4 4 2 Thrombospondin type 1 domain PLAC PF08686.9 T294858_1 - 0.085 13.5 11.1 0.035 14.7 7.4 2.5 2 0 0 2 2 2 0 PLAC (protease and lacunin) domain Pep_M12B_propep PF01562.17 T294858_3 - 4.3e-34 117.6 0.0 7.3e-34 116.9 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.12 T294858_3 - 5.6e-33 113.3 0.0 8.3e-33 112.7 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.17 T294858_3 - 1e-17 64.6 0.0 1.7e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 T294858_3 - 1.6e-13 51.2 0.1 2.5e-13 50.5 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 TSP_1 PF00090.17 T294858_3 - 4.4e-11 42.7 15.3 1.6e-09 37.7 4.8 3.2 2 0 0 2 2 2 2 Thrombospondin type 1 domain Reprolysin_3 PF13582.4 T294858_3 - 6.7e-10 39.4 0.1 1.1e-09 38.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T294858_3 - 7.6e-09 35.6 0.1 1.3e-08 34.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T294858_3 - 1.5e-05 24.6 0.1 2.6e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 T294858_3 - 0.016 14.9 0.2 0.029 14.1 0.2 1.3 1 0 0 1 1 1 0 Matrixin SR-25 PF10500.7 T088251_3 - 8e-96 319.9 50.0 1.3e-95 319.2 50.0 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.7 T088251_3 - 0.11 10.8 21.0 0.17 10.2 21.0 1.2 1 0 0 1 1 1 0 Transmembrane protein DDHD PF02862.15 T088251_3 - 2.3 8.1 10.2 4.1 7.3 10.2 1.3 1 0 0 1 1 1 0 DDHD domain DUF1777 PF08648.10 T088251_3 - 8.2 6.5 38.7 15 5.6 38.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) SRP-alpha_N PF04086.11 T088251_3 - 8.2 6.1 29.6 31 4.2 26.5 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Smg8_Smg9 PF10220.7 T088251_3 - 9 4.3 11.5 15 3.6 11.5 1.2 1 0 0 1 1 1 0 Smg8_Smg9 zf-H2C2_2 PF13465.4 T294778_1 - 3.5e-175 561.3 183.1 2.7e-08 33.7 0.5 28.7 28 0 0 28 28 28 26 Zinc-finger double domain zf-C2H2 PF00096.24 T294778_1 - 2.1e-127 408.8 199.8 1.1e-06 28.7 1.6 27.1 26 0 0 26 26 26 26 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T294778_1 - 7.4e-60 194.3 188.9 0.01 16.4 0.9 27.1 26 0 0 26 26 26 26 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T294778_1 - 4.6e-30 102.9 169.4 0.024 14.5 0.8 26.3 26 0 0 26 26 26 21 C2H2-type zinc finger KRAB PF01352.25 T294778_1 - 3.3e-23 80.9 0.3 6.3e-23 80.1 0.3 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 T294778_1 - 2e-16 59.7 123.0 0.021 14.8 2.6 16.5 9 3 10 20 20 20 17 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T294778_1 - 7e-09 35.6 126.3 2.5 8.4 0.1 24.9 25 0 0 25 25 25 9 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T294778_1 - 0.00051 19.6 0.2 0.00051 19.6 0.2 23.1 26 0 0 26 26 26 7 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 T294778_1 - 0.92 10.2 124.6 0.29 11.8 4.1 13.8 3 2 16 19 19 19 0 zinc-ribbon family KRAB PF01352.25 T294778_2 - 8.1e-17 60.5 0.1 1.6e-16 59.6 0.1 1.5 1 0 0 1 1 1 1 KRAB box WD40 PF00400.30 T329050_2 - 3.6e-10 40.1 19.8 0.00012 22.6 0.2 6.9 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T329050_2 - 6.2e-09 35.9 0.7 0.033 14.3 0.0 4.3 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 T329050_2 - 0.00052 19.8 1.1 1.1 8.9 0.1 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Rax2 PF12768.5 T329050_2 - 0.075 12.5 0.3 3.4 7.1 0.1 2.3 2 0 0 2 2 2 0 Cortical protein marker for cell polarity VitD-bind_III PF09164.8 T329050_3 - 0.97 9.3 4.3 0.77 9.7 1.2 2.4 2 0 0 2 2 2 0 Vitamin D binding protein, domain III Homeobox PF00046.27 T047510_2 - 5.1e-20 70.9 6.5 1.1e-19 69.9 6.5 1.6 1 0 0 1 1 1 1 Homeobox domain Homez PF11569.6 T047510_2 - 0.009 15.3 0.2 0.021 14.1 0.2 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Arm PF00514.21 T309267_2 - 3.4e-06 26.8 12.1 1.1 9.2 0.0 8.2 9 0 0 9 9 9 4 Armadillo/beta-catenin-like repeat PUL PF08324.9 T309267_2 - 0.46 9.6 4.4 0.58 9.3 0.2 2.8 1 1 3 4 4 4 0 PUL domain LRR_8 PF13855.4 T169367_1 - 2.9e-37 126.1 14.6 8.7e-09 34.9 0.1 5.1 4 1 0 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 T169367_1 - 1.3e-25 88.8 6.6 9.5e-08 32.1 0.4 5.6 4 2 2 6 6 6 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 T169367_1 - 7.4e-12 44.2 11.9 0.095 12.7 0.0 8.6 10 0 0 10 10 10 3 Leucine Rich repeat LRR_1 PF00560.31 T169367_1 - 9e-09 34.5 10.2 1.9 9.1 0.1 8.6 8 1 0 8 8 8 3 Leucine Rich Repeat LRR_9 PF14580.4 T169367_1 - 8.9e-05 21.9 2.5 0.15 11.4 0.2 3.5 1 1 3 4 4 4 3 Leucine-rich repeat LRR_8 PF13855.4 T169367_2 - 2.6e-11 43.0 0.0 8.3e-09 35.0 0.0 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 T169367_2 - 8.1e-06 25.9 0.0 0.026 14.8 0.0 2.3 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T169367_3 - 0.00014 21.4 2.5 0.00024 20.7 2.5 1.2 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.5 T169367_3 - 0.00058 20.0 5.0 0.001 19.3 5.0 1.3 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) tRNA-synt_1g PF09334.9 T080599_2 - 1e-145 485.3 0.0 1.5e-145 484.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) WHEP-TRS PF00458.18 T080599_2 - 1.2e-16 60.5 4.9 2.5e-16 59.4 4.9 1.6 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_1 PF00133.20 T080599_2 - 3.2e-06 25.6 0.1 0.0029 15.8 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) GST_C PF00043.23 T080599_2 - 3.9e-05 23.7 0.0 9.2e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 T080599_2 - 5.4e-05 22.9 0.0 0.00022 21.0 0.0 2.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Anticodon_1 PF08264.11 T080599_2 - 0.00064 19.6 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA GST_N_2 PF13409.4 T080599_2 - 0.056 13.7 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 T080599_2 - 0.085 12.9 0.0 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF16 PF01519.14 T080599_2 - 0.2 12.0 0.8 0.46 10.9 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 Peptidase_C1_2 PF03051.13 T080599_2 - 0.22 10.1 0.4 0.35 9.5 0.4 1.2 1 0 0 1 1 1 0 Peptidase C1-like family MMR_HSR1 PF01926.21 T051762_2 - 0.00028 20.8 0.1 0.00053 19.9 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 T051762_2 - 0.0011 18.7 0.6 0.0064 16.3 0.6 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.16 T051762_2 - 0.011 15.2 0.4 0.17 11.3 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.7 T051762_2 - 0.13 11.8 0.1 3.9 7.1 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Amino_oxidase PF01593.22 T051762_3 - 4.1e-73 247.1 0.0 5.4e-73 246.7 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 T051762_3 - 1.4e-11 44.4 1.4 2.9e-11 43.3 1.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lipase PF00151.17 T049135_1 - 6.8e-153 508.7 0.0 8.9e-153 508.4 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 T049135_1 - 2.2e-15 57.1 0.2 4.2e-15 56.2 0.2 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 T049135_1 - 0.00099 19.7 0.0 0.0017 18.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.11 T049135_1 - 0.036 13.8 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.18 T049135_1 - 0.057 12.9 0.0 0.088 12.3 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF900 PF05990.10 T049135_1 - 0.076 12.4 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_3 PF01764.23 T049135_1 - 0.076 12.8 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Lectin_C PF00059.19 T073850_1 - 0.00073 20.1 0.0 0.0014 19.2 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 T073850_2 - 1e-07 31.7 1.0 0.0014 18.1 0.1 2.3 2 0 0 2 2 2 2 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.19 T073850_2 - 6e-07 30.1 0.2 6e-07 30.1 0.2 2.2 2 0 0 2 2 2 1 Lectin C-type domain Chordopox_A33R PF05966.10 T073850_2 - 0.06 12.5 0.6 0.26 10.4 0.1 2.0 2 0 0 2 2 2 0 Chordopoxvirus A33R protein Lectin_C PF00059.19 T073850_3 - 1.5e-16 61.0 1.4 3.5e-16 59.7 1.4 1.7 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 T073850_3 - 0.00092 18.8 4.4 0.0019 17.8 4.4 1.4 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 T073850_3 - 0.021 14.0 0.3 0.036 13.2 0.3 1.2 1 0 0 1 1 1 0 Chordopoxvirus A33R protein Rho_GDI PF02115.15 T124107_1 - 1.7e-43 148.5 0.0 2.6e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Thioredoxin PF00085.18 T124107_2 - 4.7e-52 174.2 0.0 8.3e-24 83.4 0.1 3.3 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.4 T124107_2 - 1.9e-40 138.7 0.0 1.9e-34 119.1 0.0 3.1 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.4 T124107_2 - 5.3e-09 36.4 0.0 0.00032 21.0 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.11 T124107_2 - 2.2e-08 33.7 0.0 0.0044 16.3 0.0 3.2 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.4 T124107_2 - 6.7e-07 29.3 0.1 0.0093 16.0 0.0 2.8 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.19 T124107_2 - 1.4e-05 24.9 0.1 0.016 15.0 0.1 2.3 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_8 PF13905.4 T124107_2 - 0.00047 20.3 0.0 0.22 11.7 0.0 3.2 2 1 1 3 3 3 1 Thioredoxin-like TraF PF13728.4 T124107_2 - 0.0051 16.6 0.0 8.9 6.0 0.0 3.4 3 0 0 3 3 3 2 F plasmid transfer operon protein Redoxin PF08534.8 T124107_2 - 0.018 14.6 0.0 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 Redoxin DUF4710 PF15828.3 T030834_2 - 9.5e-29 99.2 0.1 2e-28 98.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4710) Aldo_ket_red PF00248.19 T036212_1 - 1.3e-55 188.5 0.0 1.8e-55 188.0 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family SP_C-Propep PF08999.8 T036212_3 - 0.48 10.1 3.6 0.9 9.2 3.6 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Reprolysin PF01421.17 T340652_3 - 1.5e-71 240.3 0.1 1.5e-71 240.3 0.1 2.0 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 T340652_3 - 5.5e-28 97.8 0.2 9.2e-28 97.1 0.2 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.10 T340652_3 - 2.6e-26 92.1 8.9 2.6e-26 92.1 8.9 3.3 3 0 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 T340652_3 - 5.9e-20 71.7 29.6 5.9e-20 71.7 29.6 4.1 4 0 0 4 4 4 1 Disintegrin Reprolysin_5 PF13688.4 T340652_3 - 1.6e-14 54.4 0.0 2.9e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T340652_3 - 1.6e-12 47.9 0.0 2.8e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T340652_3 - 1.5e-05 24.6 0.1 5.1e-05 22.9 0.1 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T340652_3 - 0.00042 20.1 0.0 0.00089 19.1 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Trypsin PF00089.24 T101913_1 - 8.9e-60 202.1 0.0 1.2e-59 201.7 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 T101913_1 - 0.00035 21.3 0.0 0.0007 20.4 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain DEAD PF00270.27 T354297_1 - 3.8e-16 59.2 0.0 5.3e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T354297_1 - 0.012 15.9 0.0 0.18 12.1 0.0 2.5 3 0 0 3 3 3 0 Helicase conserved C-terminal domain ResIII PF04851.13 T354297_1 - 0.014 15.3 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Helicase_C PF00271.29 T354297_2 - 4.8e-08 33.2 0.0 7.8e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain WD-3 PF09765.7 T189921_1 - 5.4e-94 314.6 0.0 7.2e-94 314.2 0.0 1.1 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.6 T189921_3 - 8.5e-34 115.4 3.1 2.1e-33 114.2 3.1 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.4 T189921_3 - 0.00037 20.5 3.7 0.00037 20.5 3.7 2.7 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.5 T189921_3 - 7.4 6.6 8.0 0.24 11.3 1.3 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger SEP PF08059.11 T212451_3 - 2.4e-26 91.9 0.1 5.1e-26 90.9 0.1 1.6 1 0 0 1 1 1 1 SEP domain V-set PF07686.15 T212451_3 - 9.6e-25 86.7 0.1 2.4e-11 43.6 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin V-set domain UBX PF00789.18 T212451_3 - 4.2e-18 65.2 0.0 7.6e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.4 T212451_3 - 1.1e-15 57.0 0.5 2e-15 56.2 0.5 1.5 1 0 0 1 1 1 1 UBA-like domain Ig_3 PF13927.4 T212451_3 - 1.2e-15 57.8 0.0 5e-07 30.1 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 T212451_3 - 3.1e-12 46.4 0.0 3.1e-05 23.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 T212451_3 - 7.5e-11 41.8 0.0 1.2e-05 25.1 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 T212451_3 - 1.2e-08 35.0 0.1 0.00026 21.1 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain Adeno_E3_CR1 PF02440.13 T212451_3 - 3.2e-05 23.5 0.0 0.019 14.6 0.0 2.5 2 0 0 2 2 2 2 Adenovirus E3 region protein CR1 Mt_ATP-synt_D PF05873.10 T367165_2 - 0.00081 19.1 6.5 0.00081 19.1 6.5 5.1 4 4 3 8 8 8 1 ATP synthase D chain, mitochondrial (ATP5H) NAT PF04768.11 T367165_2 - 0.0038 16.8 2.9 0.14 11.7 0.1 2.9 2 0 0 2 2 2 2 NAT, N-acetyltransferase, of N-acetylglutamate synthase Invasin_D3 PF09134.8 T367165_2 - 0.083 12.5 0.0 0.43 10.2 0.0 2.1 2 0 0 2 2 2 0 Invasin, domain 3 Sema PF01403.17 T242853_2 - 1.8e-111 372.8 0.0 2.5e-111 372.4 0.0 1.1 1 0 0 1 1 1 1 Sema domain ig PF00047.23 T242853_2 - 3.7e-05 23.7 0.0 7.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 T242853_2 - 0.00065 19.7 0.0 0.013 15.6 0.0 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T242853_2 - 0.01 16.3 0.0 0.024 15.1 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.14 T242853_2 - 0.033 14.1 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain DUF4714 PF15833.3 T242853_3 - 2.7e-85 283.6 5.3 4.2e-85 283.0 5.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4714) Sema PF01403.17 T242853_3 - 3.6e-35 121.4 0.0 4.9e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Sema domain COMPASS-Shg1 PF05205.10 T261526_3 - 1.2e-05 25.8 0.0 1.8e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 AbLIM_anchor PF16182.3 T340213_2 - 7e-78 262.9 13.0 2.9e-57 195.1 9.3 2.1 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 T340213_2 - 1.2e-14 54.0 0.8 2.1e-14 53.1 0.8 1.5 1 0 0 1 1 1 1 Villin headpiece domain STAT1_TAZ2bind PF12162.6 T340213_2 - 0.044 13.2 0.8 6.2 6.4 0.0 2.7 2 0 0 2 2 2 0 STAT1 TAZ2 binding domain LON_substr_bdg PF02190.14 T379278_2 - 3.5e-16 59.6 0.0 5.5e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.4 T379278_2 - 2.6e-14 52.7 29.1 9.8e-10 38.0 14.2 3.1 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T379278_2 - 2.1e-12 46.8 26.0 1.4e-06 28.2 5.1 3.1 2 0 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 T379278_2 - 4e-10 39.4 26.5 5.9e-06 26.1 11.1 3.1 2 0 0 2 2 2 2 RING-type zinc-finger TPR_2 PF07719.15 T379278_2 - 1.3e-09 37.3 7.9 0.035 14.1 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat zf-RING_5 PF14634.4 T379278_2 - 2.5e-09 36.8 30.8 3.4e-05 23.6 12.1 3.5 3 0 0 3 3 3 2 zinc-RING finger domain zf-C3HC4 PF00097.23 T379278_2 - 8.6e-09 35.0 33.3 1.6e-06 27.8 13.3 3.5 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T379278_2 - 1.3e-08 34.4 23.9 3.9e-07 29.7 12.2 3.7 3 0 0 3 3 2 2 Zinc finger, C3HC4 type (RING finger) TPR_11 PF13414.4 T379278_2 - 2.1e-07 30.4 2.1 0.001 18.6 0.5 3.5 2 1 1 3 3 3 2 TPR repeat zf-RING_2 PF13639.4 T379278_2 - 3.3e-06 27.1 12.6 3.3e-06 27.1 12.6 3.9 3 0 0 3 3 2 2 Ring finger domain TPR_16 PF13432.4 T379278_2 - 5.9e-05 23.5 11.2 0.061 13.9 0.1 3.5 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 T379278_2 - 0.00057 19.8 2.6 2.4 8.4 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat Prok-RING_4 PF14447.4 T379278_2 - 0.0022 17.7 31.9 0.0028 17.3 13.1 3.1 3 0 0 3 3 3 2 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 T379278_2 - 0.0028 17.8 7.1 0.0028 17.8 7.1 3.4 3 0 0 3 3 2 1 RING-H2 zinc finger domain TPR_9 PF13371.4 T379278_2 - 0.0039 17.2 0.8 0.12 12.4 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat zf-RING_10 PF16685.3 T379278_2 - 0.0058 16.6 23.4 0.12 12.4 9.2 2.9 2 0 0 2 2 2 2 zinc RING finger of MSL2 TPR_1 PF00515.26 T379278_2 - 0.031 14.0 7.2 3.3 7.6 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat U-box PF04564.13 T379278_2 - 0.061 13.4 0.0 0.18 11.9 0.0 1.7 2 0 0 2 2 1 0 U-box domain ANAPC3 PF12895.5 T379278_2 - 0.27 11.3 8.3 0.22 11.6 2.3 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.4 T379278_2 - 1 10.2 7.6 12 6.8 1.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.12 T379278_2 - 4.6 8.0 10.1 6.1 7.6 0.9 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.15 T379278_2 - 4.9 7.4 7.6 21 5.4 0.6 2.4 2 0 0 2 2 2 0 Bacterial transcriptional activator domain Laminin_N PF00055.15 T367958_2 - 4.8e-49 166.9 0.0 4.8e-49 166.9 0.0 2.2 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.22 T367958_2 - 7.2e-15 54.7 81.1 1.5e-07 31.3 13.5 5.6 5 1 1 6 6 6 3 Laminin EGF domain EGF PF00008.25 T367958_2 - 3.4e-05 23.9 6.7 3.4e-05 23.9 6.7 5.4 5 0 0 5 5 5 1 EGF-like domain EGF_2 PF07974.11 T367958_2 - 0.00074 19.7 10.6 0.00074 19.7 10.6 5.4 4 1 0 4 4 4 1 EGF-like domain BNR PF02012.18 T367958_2 - 0.16 12.0 0.4 12 6.3 0.0 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat AAA_33 PF13671.4 T092583_2 - 1.6e-14 54.2 0.0 2.6e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 T092583_2 - 0.00073 18.8 0.0 0.0014 17.8 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.4 T092583_2 - 0.00078 19.8 0.0 0.0022 18.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 T092583_2 - 0.011 15.1 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_16 PF13191.4 T092583_2 - 0.049 13.9 0.0 0.081 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.4 T092583_3 - 1.9e-14 53.9 0.0 3.9e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 T092583_3 - 0.00012 22.5 0.4 0.00054 20.3 0.0 2.4 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.10 T092583_3 - 0.0017 17.5 0.0 0.0032 16.7 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.4 T092583_3 - 0.0052 17.0 0.0 0.0091 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.4 T092583_3 - 0.018 14.6 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Thyroglobulin_1 PF00086.16 T147119_2 - 1.6e-18 66.0 1.1 4.3e-18 64.6 1.1 1.8 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 T147119_2 - 2.7e-08 34.2 20.4 2.7e-08 34.2 20.4 3.9 3 0 0 3 3 3 1 Insulin-like growth factor binding protein TUSC2 PF15000.4 T242905_1 - 4.8e-41 139.4 0.0 8.4e-41 138.6 0.0 1.4 1 0 0 1 1 1 1 Tumour suppressor candidate 2 NPR2 PF06218.9 T242905_1 - 9.1e-23 80.6 0.0 1.7e-18 66.5 0.0 2.1 2 0 0 2 2 2 2 Nitrogen permease regulator 2 RA PF00788.21 T242905_1 - 2.1e-17 63.4 0.1 4.7e-17 62.3 0.1 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.3 T242905_1 - 3.4e-17 62.0 4.5 9.1e-17 60.6 4.5 1.8 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain zf-MYND PF01753.16 T242905_1 - 3.9e-06 26.7 24.9 3.9e-06 26.7 24.9 2.5 2 0 0 2 2 2 1 MYND finger C1_1 PF00130.20 T242905_2 - 2.3e-06 27.3 14.0 2.3e-06 27.3 14.0 2.7 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) NPR2 PF06218.9 T242905_3 - 1.5e-55 188.6 0.9 5.6e-39 134.0 1.0 2.1 1 1 1 2 2 2 2 Nitrogen permease regulator 2 Sema PF01403.17 T278781_3 - 1.6e-131 438.9 0.0 2.2e-131 438.4 0.0 1.2 1 0 0 1 1 1 1 Sema domain TSP_1 PF00090.17 T278781_3 - 1.2e-41 140.5 96.5 5.4e-11 42.4 8.3 7.1 7 0 0 7 7 7 6 Thrombospondin type 1 domain zf-CCCH PF00642.22 T300470_1 - 4e-05 23.3 4.4 0.00011 21.9 4.4 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pkinase PF00069.23 T114716_2 - 1.7e-66 224.1 0.0 2.2e-66 223.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T114716_2 - 8.7e-45 152.9 0.0 1.2e-44 152.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 T114716_2 - 1.1e-15 57.6 0.1 2.4e-15 56.5 0.1 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 T114716_2 - 3.6e-07 29.7 0.0 5.4e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 T114716_2 - 0.097 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MyTH4 PF00784.15 T147834_2 - 4.7e-21 75.2 0.0 9.8e-21 74.1 0.0 1.5 1 0 0 1 1 1 1 MyTH4 domain FERM_M PF00373.16 T147834_2 - 6.6e-07 29.6 0.0 3.9e-06 27.1 0.0 2.0 1 1 0 1 1 1 1 FERM central domain RA PF00788.21 T147834_2 - 3.1e-05 24.4 0.0 7.2e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 T147834_2 - 0.0011 19.3 0.0 0.0019 18.6 0.0 1.4 1 0 0 1 1 1 1 PH domain Porin_3 PF01459.20 T044271_2 - 2.6e-82 276.2 1.4 3.2e-82 275.9 1.4 1.1 1 0 0 1 1 1 1 Eukaryotic porin MARVEL PF01284.21 T374609_2 - 1.8e-11 44.1 11.3 5.2e-11 42.6 11.3 1.8 1 0 0 1 1 1 1 Membrane-associating domain DUF2070 PF09843.7 T374609_2 - 6.5 4.8 5.1 12 3.9 5.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PDZ PF00595.22 T374609_3 - 5.3e-13 49.0 0.0 8.8e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T374609_3 - 0.11 12.7 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 PDZ domain Hexokinase_2 PF03727.14 T043221_1 - 1.2e-56 191.7 0.0 1.6e-56 191.3 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.14 T043221_3 - 3.1e-103 344.3 1.2 1.6e-77 260.0 0.0 2.1 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.19 T043221_3 - 6.5e-74 248.1 0.0 9e-74 247.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase CENP-F_N PF10481.7 T030349_1 - 6.9e-160 531.6 40.0 6.9e-160 531.6 40.0 17.2 4 2 11 17 17 17 1 Cenp-F N-terminal domain CENP-F_leu_zip PF10473.7 T030349_1 - 4e-104 344.3 117.0 3.8e-51 172.6 32.3 25.2 10 5 15 25 25 25 6 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-F_C_Rb_bdg PF10490.7 T030349_1 - 2.3e-25 87.6 0.4 4.7e-25 86.6 0.4 1.5 1 0 0 1 1 1 1 Rb-binding domain of kinetochore protein Cenp-F/LEK1 Lectin_N PF03954.12 T030349_1 - 0.0025 17.4 9.7 0.0025 17.4 9.7 23.7 12 7 11 24 24 24 2 Hepatic lectin, N-terminal domain Y_phosphatase PF00102.25 T158297_1 - 8.5e-78 261.0 0.1 1.6e-77 260.1 0.1 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.19 T158297_1 - 1.7e-26 92.2 8.2 1.3e-09 38.1 0.0 5.2 5 0 0 5 5 5 3 Fibronectin type III domain ig PF00047.23 T158297_1 - 3.6e-05 23.7 0.0 0.00012 22.0 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 T158297_1 - 0.00095 19.6 1.1 0.33 11.4 0.1 3.6 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain DSPc PF00782.18 T158297_1 - 0.0026 17.4 0.0 0.0054 16.4 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain ECSCR PF15820.3 T158297_1 - 0.0032 17.1 0.1 0.0069 16.1 0.1 1.4 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator Y_phosphatase3 PF13350.4 T158297_1 - 0.016 15.0 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family EphA2_TM PF14575.4 T158297_1 - 0.043 14.5 0.2 0.19 12.4 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain PTPlike_phytase PF14566.4 T158297_1 - 0.057 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate DctM PF06808.10 T158297_1 - 0.076 11.7 0.2 0.11 11.1 0.2 1.1 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporter, DctM component DUF948 PF06103.9 T158297_1 - 0.16 12.1 0.1 0.3 11.2 0.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Y_phosphatase PF00102.25 T158297_2 - 7.4e-64 215.4 0.1 1.9e-63 214.0 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.18 T158297_2 - 0.015 15.0 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Homeobox PF00046.27 T367998_1 - 1.3e-21 76.0 5.6 2.3e-21 75.2 5.6 1.4 1 0 0 1 1 1 1 Homeobox domain TFR_dimer PF04253.13 T060990_2 - 5.1e-23 81.3 0.0 8.3e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.15 T060990_2 - 6.7e-21 74.7 0.0 1.5e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.20 T060990_2 - 1.7e-08 34.4 0.0 3.9e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.13 T060990_2 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Nicastrin RtcB PF01139.15 T232550_1 - 8.9e-145 482.8 0.2 1.1e-144 482.5 0.2 1.1 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB PET PF06297.12 T374643_1 - 2.7e-22 78.8 0.3 5.1e-22 77.8 0.3 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 T374643_2 - 4.7e-22 77.8 40.0 4.7e-09 36.2 6.6 3.5 3 0 0 3 3 3 3 LIM domain PET PF06297.12 T374643_2 - 5.1e-07 29.8 0.1 9.1e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 PET Domain AF-4 PF05110.11 T374643_2 - 0.083 10.8 4.6 0.13 10.3 4.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF755 PF05501.9 T374643_2 - 5.5 7.1 13.7 10 6.3 13.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) MARVEL PF01284.21 T374643_3 - 4.3e-43 146.7 3.2 8.2e-43 145.8 3.2 1.5 1 0 0 1 1 1 1 Membrane-associating domain RRM_1 PF00076.20 T220660_3 - 5e-12 45.3 0.0 9.1e-12 44.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T220660_3 - 0.013 15.5 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 RNA recognition motif DNA_pol_A_exo1 PF01612.18 T106463_2 - 2.4e-17 63.1 0.0 4.1e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease RRXRR PF14239.4 T106463_2 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 RRXRR protein Serpin PF00079.18 T229737_1 - 2.6e-102 342.8 5.3 3.6e-102 342.3 5.3 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) AAA_9 PF12781.5 T229737_1 - 0.03 13.3 1.3 0.065 12.2 1.3 1.4 1 1 0 1 1 1 0 ATP-binding dynein motor region D5 Mab-21 PF03281.12 T211422_1 - 6.8e-10 38.6 0.0 1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein His_Phos_2 PF00328.20 T115533_1 - 4.4e-135 450.8 1.4 9.2e-135 449.7 0.0 1.9 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.9 T115533_1 - 0.058 12.9 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Synuclein PF01387.15 T268094_1 - 6e-52 175.3 17.6 8e-52 174.8 17.6 1.2 1 0 0 1 1 1 1 Synuclein SPATIAL PF15256.4 T043507_2 - 7.4e-20 72.0 0.3 1.2e-19 71.3 0.3 1.3 1 0 0 1 1 1 1 SPATIAL HAP1_N PF04849.11 T147542_1 - 2.4e-99 332.3 29.0 7.7e-96 320.8 20.5 2.1 2 0 0 2 2 2 2 HAP1 N-terminal conserved region CDC45 PF02724.12 T147542_1 - 0.056 11.6 6.1 0.088 11.0 6.1 1.2 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.10 T147542_1 - 0.75 9.0 6.6 1.3 8.1 6.6 1.3 1 0 0 1 1 1 0 NOA36 protein RNA_pol_3_Rpc31 PF11705.6 T147542_1 - 1 9.4 9.6 1.9 8.6 9.6 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 HAP1_N PF04849.11 T147542_3 - 1.7e-06 27.4 0.2 2.3e-06 26.9 0.2 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region RFamide_26RFa PF11109.6 T367766_1 - 6.6e-63 211.0 0.2 6.6e-63 211.0 0.2 2.0 2 0 0 2 2 2 1 Orexigenic neuropeptide Qrfp/P518 Fibrinogen_C PF00147.16 T367766_2 - 4.2e-74 248.9 2.7 6.1e-74 248.4 2.7 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain ATG16 PF08614.9 T367766_2 - 0.14 12.2 1.1 0.28 11.2 1.1 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.7 T367766_2 - 0.33 10.9 0.3 0.57 10.1 0.3 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 H2TH PF06831.12 T338977_1 - 3e-12 46.2 0.0 5.6e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain GATA-N PF05349.10 T338977_2 - 1.6e-50 171.8 21.3 3.3e-50 170.7 21.3 1.6 1 0 0 1 1 1 1 GATA-type transcription activator, N-terminal GATA PF00320.25 T338977_2 - 2e-26 91.2 15.4 1.2e-13 50.3 4.3 2.9 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 T338977_2 - 0.00092 18.5 5.2 0.29 10.6 0.6 2.6 2 0 0 2 2 2 2 TFIIB zinc-binding Zip PF02535.20 T153686_2 - 8.1e-24 84.3 10.8 1.7e-23 83.2 10.8 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter DUF1725 PF08333.9 T019433_1 - 3.7e-05 23.1 0.5 0.0001 21.7 0.5 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) HTH_9 PF08221.9 T019433_2 - 1.9e-19 69.4 0.7 3e-19 68.7 0.7 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain RNA_pol_Rpc82 PF05645.11 T019433_3 - 2.9e-42 145.1 0.0 8.6e-42 143.5 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 HDNR PF15115.4 T050453_3 - 9.6e-26 90.9 0.1 1.3e-25 90.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function with conserved HDNR motif PDZ PF00595.22 T355793_2 - 6.5e-167 542.2 60.9 1.7e-19 69.8 0.0 14.1 13 1 1 14 14 14 13 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T355793_2 - 1.4e-56 188.6 25.0 1.1e-05 25.5 0.1 12.6 12 0 0 12 12 12 11 PDZ domain L27_2 PF09045.8 T355793_2 - 3.1e-34 116.6 5.6 6.9e-34 115.5 5.6 1.6 1 0 0 1 1 1 1 L27_2 MPDZ_u10 PF16667.3 T355793_2 - 8.9e-31 106.5 11.5 8.9e-31 106.5 11.5 3.1 2 0 0 2 2 2 1 Unstructured region 10 on multiple PDZ protein L27_1 PF09058.8 T355793_2 - 0.071 13.1 0.7 0.17 11.9 0.7 1.6 1 0 0 1 1 1 0 L27_1 TPR_19 PF14559.4 T202349_1 - 1.8e-44 150.0 66.4 1.3e-05 25.5 2.7 17.9 11 7 8 20 20 20 13 Tetratricopeptide repeat TPR_2 PF07719.15 T202349_1 - 1.7e-36 121.3 57.3 0.0032 17.3 0.0 20.3 21 0 0 21 21 21 10 Tetratricopeptide repeat TPR_14 PF13428.4 T202349_1 - 7.1e-35 116.6 36.6 0.096 13.4 0.6 20.3 12 5 10 22 22 20 9 Tetratricopeptide repeat TPR_1 PF00515.26 T202349_1 - 7.3e-26 88.8 49.4 0.00044 19.8 0.1 17.7 17 0 0 17 17 17 7 Tetratricopeptide repeat TPR_16 PF13432.4 T202349_1 - 5.5e-23 81.2 21.1 0.71 10.5 0.0 14.6 12 1 4 16 16 15 5 Tetratricopeptide repeat TPR_8 PF13181.4 T202349_1 - 2.7e-22 77.0 39.0 0.029 14.5 0.0 13.9 14 0 0 14 14 11 7 Tetratricopeptide repeat ANAPC3 PF12895.5 T202349_1 - 3.6e-19 68.6 50.2 0.00065 19.7 0.0 12.3 9 4 7 16 16 16 6 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.4 T202349_1 - 2.1e-15 56.7 49.1 0.015 15.4 2.0 15.5 11 5 8 19 19 19 6 Tetratricopeptide repeat TPR_11 PF13414.4 T202349_1 - 3.5e-14 52.0 29.0 0.00039 19.9 0.5 10.0 9 1 2 11 11 10 4 TPR repeat TPR_7 PF13176.4 T202349_1 - 1.7e-12 46.3 20.7 0.11 12.4 0.1 11.6 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_6 PF13174.4 T202349_1 - 1.7e-11 43.9 44.1 0.35 11.5 0.1 17.1 20 0 0 20 20 16 2 Tetratricopeptide repeat TPR_21 PF09976.7 T202349_1 - 1.4e-10 41.1 24.8 0.02 14.5 0.5 7.7 5 2 1 7 7 7 4 Tetratricopeptide repeat-like domain TPR_17 PF13431.4 T202349_1 - 2.3e-10 40.0 21.9 0.0016 18.6 0.1 11.7 12 1 0 12 12 10 2 Tetratricopeptide repeat TPR_9 PF13371.4 T202349_1 - 3.3e-07 30.2 17.4 0.018 15.1 0.0 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat PknG_TPR PF16918.3 T202349_1 - 0.00029 19.5 1.5 5.6 5.5 0.0 5.2 5 1 1 6 6 6 1 Protein kinase G tetratricopeptide repeat TPR_10 PF13374.4 T202349_1 - 0.0014 18.3 21.0 7.6 6.4 0.1 10.7 12 0 0 12 12 12 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 T202349_1 - 0.0024 17.8 29.6 1.6 8.7 0.0 9.2 9 1 1 10 10 9 2 Fis1 C-terminal tetratricopeptide repeat Alkyl_sulf_dimr PF14863.4 T202349_1 - 0.0029 17.9 12.5 5.3 7.4 0.1 5.9 5 1 1 6 6 6 1 Alkyl sulfatase dimerisation TPR_20 PF14561.4 T202349_1 - 0.0033 17.6 25.6 3.2 8.0 0.6 9.9 8 2 3 11 11 10 1 Tetratricopeptide repeat PPR PF01535.18 T202349_1 - 0.091 12.9 7.8 1.4e+02 3.0 0.0 7.5 10 0 0 10 10 6 0 PPR repeat TPR_4 PF07721.12 T202349_1 - 0.095 13.3 15.3 1.1 10.0 0.1 6.5 7 0 0 7 7 5 0 Tetratricopeptide repeat Tcf25 PF04910.12 T202349_1 - 0.84 8.5 11.5 3.6 6.5 0.1 5.1 6 1 1 7 7 7 0 Transcriptional repressor TCF25 SPOB_a PF14689.4 T202349_1 - 0.89 9.2 6.4 1.1 8.9 0.0 4.0 5 0 0 5 5 5 0 Sensor_kinase_SpoOB-type, alpha-helical domain SRP_TPR_like PF17004.3 T202349_1 - 8.2 6.3 16.4 0.79 9.6 2.4 5.8 6 2 0 6 6 5 0 Putative TPR-like repeat GPS2_interact PF15784.3 T142486_2 - 5.7e-35 119.7 6.8 5.7e-35 119.7 6.8 4.3 3 0 0 3 3 3 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 T142486_2 - 1e-17 63.8 0.2 5.9e-12 45.4 0.2 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T142486_2 - 0.0069 16.5 1.9 0.091 12.9 0.3 2.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Alpha-amylase_C PF02806.16 T016352_2 - 6.7e-15 55.2 0.1 1.5e-14 54.1 0.1 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.22 T016352_2 - 1.6e-13 50.8 0.0 3.1e-13 49.9 0.0 1.4 1 1 0 1 1 1 1 Alpha amylase, catalytic domain zf-H2C2_2 PF13465.4 T054639_2 - 9.3e-35 117.4 48.7 8.4e-08 32.2 0.6 7.5 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 T054639_2 - 5.6e-27 92.5 47.4 6.5e-06 26.2 1.3 8.0 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T054639_2 - 1.2e-16 59.8 43.8 0.0062 17.1 0.6 7.9 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_8 PF15909.3 T054639_2 - 1.6e-05 25.0 16.2 0.048 13.8 4.4 3.5 1 1 2 3 3 3 3 C2H2-type zinc ribbon CopK PF11525.6 T054639_2 - 0.00017 21.0 0.9 4.3 6.9 0.0 4.5 4 1 1 5 5 5 2 Copper resistance protein K zf-C2H2_jaz PF12171.6 T054639_2 - 0.0074 16.4 15.7 5.6 7.3 0.4 6.3 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.3 T054639_2 - 0.015 15.3 23.9 0.31 11.0 0.4 5.7 3 1 3 6 6 6 0 Aberrant zinc-finger FOXP-CC PF16159.3 T054639_2 - 0.46 11.0 12.3 0.66 10.5 0.8 5.0 4 2 1 5 5 5 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.4 T054639_2 - 0.86 9.5 24.8 0.041 13.7 0.6 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger MHC_I PF00129.16 T178817_1 - 1.8e-42 144.8 0.0 2.9e-42 144.1 0.0 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 EF-hand_1 PF00036.30 T178817_1 - 7.3e-09 34.4 0.7 0.34 10.4 0.0 4.5 4 0 0 4 4 4 3 EF hand C1-set PF07654.13 T178817_1 - 2.8e-08 34.0 0.0 5.4e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain EF-hand_7 PF13499.4 T178817_1 - 3.5e-08 33.7 2.2 0.00048 20.4 0.5 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 T178817_1 - 2.5e-07 30.0 1.1 2 8.5 0.0 4.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.4 T178817_1 - 6.7e-06 25.3 5.4 0.32 10.5 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.4 T178817_1 - 9.8e-05 21.9 0.4 0.032 13.9 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain pair MHC_I_3 PF16497.3 T178817_1 - 0.0011 18.4 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain Ski_Sno PF02437.15 T096013_1 - 2.3e-38 130.1 0.1 4.2e-38 129.3 0.1 1.4 1 0 0 1 1 1 1 SKI/SNO/DAC family Tubulin PF00091.23 T036305_1 - 1.7e-61 207.8 0.0 2.1e-61 207.4 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 T036305_1 - 3.3e-48 162.9 0.0 4.9e-48 162.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 T036305_1 - 0.0032 17.0 0.0 0.0071 15.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain RRM_1 PF00076.20 T058265_2 - 8.6e-51 169.5 0.0 9.3e-18 63.7 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 T058265_2 - 8.3e-08 32.0 0.0 0.17 11.8 0.0 3.7 3 0 0 3 3 3 3 RNA binding domain RRM_7 PF16367.3 T058265_2 - 0.00013 21.9 0.0 0.69 9.9 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.4 T058265_2 - 0.00013 21.4 0.3 0.081 12.4 0.1 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 T058265_2 - 0.0072 16.1 0.0 0.89 9.4 0.0 3.2 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.4 T058265_2 - 0.1 12.7 3.1 4.7 7.3 0.4 3.2 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Filament PF00038.19 T078960_1 - 4.1e-117 391.1 37.9 5e-117 390.8 37.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 T078960_1 - 3.6e-19 69.4 0.7 3.6e-19 69.4 0.7 2.8 2 1 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 T078960_1 - 3.8e-06 26.8 30.9 0.00083 19.3 0.3 3.9 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.4 T078960_1 - 4.3e-05 22.3 16.4 4.3e-05 22.3 16.4 1.6 1 1 0 1 1 1 1 AAA domain Spc7 PF08317.9 T078960_1 - 0.00024 19.9 33.9 0.00093 18.0 6.8 3.1 1 1 3 4 4 4 4 Spc7 kinetochore protein CENP-F_leu_zip PF10473.7 T078960_1 - 0.00039 20.3 28.1 0.0084 16.0 8.9 3.4 1 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Alanine_zipper PF11839.6 T078960_1 - 0.0021 18.2 6.0 0.0021 18.2 6.0 2.0 2 0 0 2 2 1 1 Alanine-zipper, major outer membrane lipoprotein ATG16 PF08614.9 T078960_1 - 0.0041 17.2 27.3 0.29 11.2 4.4 2.6 1 1 0 2 2 2 2 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.5 T078960_1 - 0.015 15.3 12.2 0.015 15.3 12.2 3.5 2 1 1 3 3 3 0 Tropomyosin like Reo_sigmaC PF04582.10 T078960_1 - 0.018 14.3 6.0 0.42 9.8 0.4 2.6 1 1 0 2 2 2 0 Reovirus sigma C capsid protein Taxilin PF09728.7 T078960_1 - 0.026 13.6 29.7 0.47 9.5 29.7 2.9 1 1 0 1 1 1 0 Myosin-like coiled-coil protein Golgin_A5 PF09787.7 T078960_1 - 0.054 12.8 29.7 0.02 14.2 11.2 3.0 1 1 3 4 4 4 0 Golgin subfamily A member 5 DUF5082 PF16888.3 T078960_1 - 0.057 13.6 23.6 0.24 11.6 0.9 4.1 1 1 2 4 4 4 0 Domain of unknown function (DUF5082) DUF745 PF05335.11 T078960_1 - 0.099 12.2 17.5 0.056 13.0 9.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF745) IncA PF04156.12 T078960_1 - 0.14 11.8 28.4 0.7 9.5 14.8 3.2 1 1 1 2 2 2 0 IncA protein Baculo_PEP_C PF04513.10 T078960_1 - 0.14 12.0 20.5 0.034 14.0 1.3 4.1 1 1 3 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus ADIP PF11559.6 T078960_1 - 0.2 11.6 28.1 0.21 11.5 11.2 3.6 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Ax_dynein_light PF10211.7 T078960_1 - 0.26 11.1 29.2 1.4 8.7 10.3 3.2 1 1 2 3 3 3 0 Axonemal dynein light chain Jnk-SapK_ap_N PF09744.7 T078960_1 - 0.45 10.6 29.2 0.067 13.3 2.4 3.5 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 DUF3584 PF12128.6 T078960_1 - 0.47 7.8 30.5 0.17 9.2 15.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF883 PF05957.11 T078960_1 - 0.61 10.6 17.1 1.5 9.3 5.7 3.7 3 1 2 5 5 4 0 Bacterial protein of unknown function (DUF883) Lebercilin PF15619.4 T078960_1 - 0.77 9.2 32.2 0.19 11.2 14.6 2.6 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ATPase PF06745.11 T078960_1 - 0.81 8.8 5.7 8.6 5.5 0.9 2.6 2 1 1 3 3 3 0 KaiC Tup_N PF08581.8 T078960_1 - 1.2 9.4 26.6 2.2 8.5 0.4 5.7 2 2 4 6 6 6 0 Tup N-terminal ISG65-75 PF11727.6 T078960_1 - 1.6 7.8 11.2 0.33 10.0 5.2 2.2 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF342 PF03961.11 T078960_1 - 1.7 7.0 21.2 1.8 7.0 8.9 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF342) APG6 PF04111.10 T078960_1 - 1.7 7.8 34.3 0.08 12.2 10.5 3.1 1 1 2 3 3 3 0 Autophagy protein Apg6 NPV_P10 PF05531.10 T078960_1 - 1.8 9.0 11.8 7 7.1 0.9 4.5 2 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DASH_Duo1 PF08651.8 T078960_1 - 1.9 8.2 10.5 2.1 8.1 0.9 4.0 3 1 0 4 4 4 0 DASH complex subunit Duo1 WXG100 PF06013.10 T078960_1 - 2.1 8.5 8.9 11 6.1 1.3 4.0 2 1 1 3 3 3 0 Proteins of 100 residues with WXG DUF1664 PF07889.10 T078960_1 - 2.1 8.2 17.7 1 9.3 1.5 4.2 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) Vps51 PF08700.9 T078960_1 - 2.6 8.1 11.6 0.36 10.8 1.3 3.8 3 1 1 4 4 4 0 Vps51/Vps67 COG5 PF10392.7 T078960_1 - 2.7 8.1 11.3 0.066 13.3 2.4 2.6 2 2 2 4 4 2 0 Golgi transport complex subunit 5 DUF948 PF06103.9 T078960_1 - 3.1 8.0 13.6 2.2 8.4 1.5 4.2 3 2 3 6 6 5 0 Bacterial protein of unknown function (DUF948) Virulence_fact PF13769.4 T078960_1 - 3.9 7.5 10.1 4.6 7.3 0.1 3.5 3 1 1 4 4 3 0 Virulence factor DUF1192 PF06698.9 T078960_1 - 4 7.4 7.1 0.88 9.5 0.2 3.1 3 1 0 3 3 2 0 Protein of unknown function (DUF1192) Fib_alpha PF08702.8 T078960_1 - 4.1 7.5 27.2 0.72 9.9 4.6 3.9 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family CHDCT2 PF08074.9 T078960_1 - 4.3 7.3 16.2 7.2 6.6 5.0 2.7 1 1 2 3 3 3 0 CHDCT2 (NUC038) domain DUF1451 PF07295.9 T078960_1 - 4.6 7.2 16.4 4.1 7.3 3.9 2.7 1 1 0 2 2 2 0 Zinc-ribbon containing domain TMF_TATA_bd PF12325.6 T078960_1 - 4.8 7.3 27.9 3.9 7.6 9.1 3.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF2746 PF10874.6 T078960_1 - 5.7 7.2 5.9 0.73 10.1 0.3 2.3 3 0 0 3 3 2 0 Protein of unknown function (DUF2746) DUF4407 PF14362.4 T078960_1 - 6.2 5.9 23.6 6e+03 -3.9 23.6 2.5 1 1 0 1 1 0 0 Domain of unknown function (DUF4407) Transposase_22 PF02994.12 T078960_1 - 6.3 5.4 21.0 0.086 11.6 8.6 2.2 1 1 1 2 2 2 0 L1 transposable element Cob_adeno_trans PF01923.16 T078960_1 - 6.7 6.7 10.2 11 6.0 7.1 2.5 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Wtap PF17098.3 T078960_1 - 7.5 6.4 21.9 0.088 12.6 1.7 3.9 2 2 1 3 3 3 0 WTAP/Mum2p family SlyX PF04102.10 T078960_1 - 7.9 7.1 21.0 0.088 13.3 1.3 4.5 3 1 1 4 4 4 0 SlyX RPW8 PF05659.9 T078960_1 - 9.5 5.8 13.0 12 5.5 0.3 3.4 2 2 1 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 zf-C2H2 PF00096.24 T035126_2 - 1.1e-14 53.9 40.8 0.00065 19.9 0.6 6.2 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T035126_2 - 3.9e-08 33.3 37.5 0.07 13.9 1.9 7.3 6 0 0 6 6 6 4 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T035126_2 - 1.2e-05 25.3 42.9 4.5e-05 23.6 0.3 5.8 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_8 PF15909.3 T035126_2 - 0.00025 21.2 7.8 0.00025 21.2 7.8 2.3 2 1 0 2 2 2 1 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.3 T035126_2 - 0.16 12.0 2.9 0.17 11.9 0.5 2.0 1 1 1 2 2 2 0 Aberrant zinc-finger Zn-ribbon_8 PF09723.8 T035126_2 - 1.3 9.1 9.9 11 6.1 0.1 3.5 3 0 0 3 3 3 0 Zinc ribbon domain CpXC PF14353.4 T035126_2 - 1.6 8.6 4.5 17 5.3 0.8 3.2 1 1 0 2 2 2 0 CpXC protein XAP5 PF04921.12 T296222_3 - 9.5e-80 267.7 9.0 9.5e-80 267.7 9.0 1.4 1 1 0 1 1 1 1 XAP5, circadian clock regulator KASH_CCD PF14662.4 T189677_2 - 0.047 13.4 248.2 0.008 15.9 17.7 9.7 1 1 8 9 9 9 0 Coiled-coil region of CCDC155 or KASH PMP22_Claudin PF00822.18 T009192_1 - 1.7e-40 138.5 5.7 2.8e-40 137.8 5.7 1.4 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 T009192_1 - 2.1e-07 30.8 8.7 4.8e-07 29.6 8.7 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.9 T009192_1 - 0.02 14.6 3.3 0.057 13.1 3.3 1.7 1 0 0 1 1 1 0 Amastin surface glycoprotein Mntp PF02659.13 T009192_1 - 0.44 10.2 2.8 0.74 9.4 2.8 1.3 1 0 0 1 1 1 0 Putative manganese efflux pump 2OG-FeII_Oxy_3 PF13640.4 T009192_3 - 2.8e-09 37.6 0.0 5.6e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.18 T009192_3 - 8.6e-09 35.7 0.0 1.8e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.15 T009192_3 - 0.0016 18.3 4.2 5.7 7.2 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.26 T009192_3 - 0.87 9.4 3.1 14 5.5 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat YfiO PF13525.4 T009192_3 - 1.1 8.7 5.1 7.7 6.0 0.4 2.2 2 0 0 2 2 2 0 Outer membrane lipoprotein Na_H_Exchanger PF00999.19 T276977_1 - 1.2e-84 284.2 50.5 1.6e-84 283.8 50.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.3 T276977_3 - 0.12 12.5 4.6 0.28 11.3 4.6 1.5 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin SPAR_C PF11881.6 T174804_2 - 2.3e-91 305.9 0.8 3.7e-91 305.2 0.8 1.4 1 0 0 1 1 1 1 C-terminal domain of SPAR protein Rap_GAP PF02145.13 T174804_2 - 1.4e-65 220.2 0.1 2e-65 219.7 0.1 1.2 1 0 0 1 1 1 1 Rap/ran-GAP PDZ PF00595.22 T174804_2 - 0.00074 19.7 0.0 0.0012 19.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) IncA PF04156.12 T174804_2 - 0.018 14.7 1.4 0.029 14.0 1.4 1.3 1 0 0 1 1 1 0 IncA protein HAUS-augmin3 PF14932.4 T174804_2 - 0.87 8.9 4.3 1.3 8.4 4.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 CENP-K PF11802.6 T174804_2 - 1.2 8.5 4.4 2 7.8 4.4 1.2 1 0 0 1 1 1 0 Centromere-associated protein K VGLL4 PF15245.4 T238069_1 - 5e-87 291.4 3.9 9.9e-87 290.4 3.9 1.4 1 0 0 1 1 1 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.12 T238069_1 - 0.00014 21.4 0.0 0.47 10.1 0.0 2.4 2 0 0 2 2 2 2 Vestigial/Tondu family LMBR1 PF04791.14 T336853_1 - 5.7e-89 299.2 28.0 2.1e-85 287.4 28.0 2.2 1 1 0 1 1 1 1 LMBR1-like membrane protein DUF912 PF06024.10 T336853_1 - 0.0081 16.3 0.4 0.031 14.4 0.0 2.1 2 0 0 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF912) Sigma_reg_N PF13800.4 T336853_1 - 0.16 12.1 2.6 1.8 8.8 0.0 3.4 4 0 0 4 4 4 0 Sigma factor regulator N-terminal ORC5_C PF14630.4 T330551_2 - 1.5e-66 224.8 0.1 2.1e-66 224.3 0.1 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.4 T330551_2 - 7e-14 52.4 0.0 1.2e-13 51.7 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 T330551_2 - 4.3e-07 30.1 0.2 1.2e-06 28.7 0.1 1.7 2 0 0 2 2 2 1 AAA domain Kinesin PF00225.21 T330551_2 - 0.1 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Kinesin motor domain Zona_pellucida PF00100.21 T059570_1 - 4e-09 36.5 0.0 6.6e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain Trefoil PF00088.16 T059570_1 - 0.0022 17.7 8.3 0.0064 16.2 7.9 2.1 1 1 0 1 1 1 1 Trefoil (P-type) domain Zona_pellucida PF00100.21 T059570_3 - 2.6e-27 96.1 0.0 3.7e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Sushi PF00084.18 T024832_2 - 7.7e-51 170.4 67.0 7.4e-10 39.2 5.7 7.1 7 0 0 7 7 7 6 Sushi repeat (SCR repeat) Lectin_C PF00059.19 T024832_2 - 2.2e-23 82.9 2.9 2.2e-23 82.9 2.9 2.7 3 0 0 3 3 3 1 Lectin C-type domain EGF PF00008.25 T024832_2 - 8.5e-06 25.8 8.6 8.5e-06 25.8 8.6 3.8 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.5 T024832_2 - 0.00041 20.8 6.1 0.00041 20.8 6.1 4.2 4 0 0 4 4 4 1 Human growth factor-like EGF Plasmod_Pvs28 PF06247.9 T024832_2 - 0.003 17.7 11.2 0.067 13.4 11.2 3.2 1 1 0 1 1 1 1 Pvs28 EGF domain EGF_2 PF07974.11 T024832_2 - 0.0034 17.6 12.4 0.0034 17.6 12.4 4.0 2 0 0 2 2 2 1 EGF-like domain EGF_3 PF12947.5 T024832_2 - 1.8 8.7 21.5 0.028 14.5 8.0 4.3 3 1 0 3 3 3 0 EGF domain SNF PF00209.16 T277516_1 - 2.2e-101 340.0 5.7 3.1e-101 339.5 5.7 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.16 T277516_3 - 2.1e-53 181.7 6.1 2.9e-53 181.2 6.1 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Cadherin PF00028.15 T330692_2 - 1.1e-52 176.3 0.8 8.5e-16 58.0 0.1 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_3 PF16184.3 T330692_2 - 7.5e-06 25.8 0.5 0.083 12.8 0.0 3.8 4 0 0 4 4 4 2 Cadherin-like Cadherin_2 PF08266.10 T330692_2 - 3.3e-05 23.5 0.0 0.0025 17.4 0.0 3.0 2 1 0 2 2 2 1 Cadherin-like DENN PF02141.19 T352621_1 - 2e-47 161.4 4.7 3.4e-47 160.7 4.7 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.17 T352621_1 - 4.8e-05 23.1 1.4 0.00013 21.8 1.4 1.8 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.16 T352621_1 - 0.0002 22.0 0.0 0.00085 20.0 0.0 2.0 1 0 0 1 1 1 1 uDENN domain DUF1725 PF08333.9 T352621_1 - 0.00029 20.3 0.8 0.00059 19.3 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) WD40 PF00400.30 T352621_1 - 0.0022 18.7 0.5 0.22 12.3 0.1 4.0 3 0 0 3 3 3 1 WD domain, G-beta repeat RVT_1 PF00078.25 T352621_2 - 0.0077 15.6 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Josephin PF02099.15 T179231_1 - 3.3e-24 85.6 0.0 1.9e-23 83.2 0.0 1.9 1 1 0 1 1 1 1 Josephin LRR_8 PF13855.4 T179231_3 - 1.2e-41 140.2 24.0 1.6e-14 53.2 2.6 4.7 2 2 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 T179231_3 - 1.1e-21 76.3 24.1 2.1e-05 24.6 0.2 5.9 2 1 4 7 7 7 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 T179231_3 - 4.1e-20 71.9 0.0 7.5e-13 48.4 0.0 2.2 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) I-set PF07679.14 T179231_3 - 2.2e-15 56.3 0.0 3.3e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T179231_3 - 6.9e-12 45.7 0.2 1.4e-11 44.7 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.4 T179231_3 - 1.4e-09 37.6 4.8 2.9e-06 26.8 0.3 2.2 1 1 0 2 2 2 2 Leucine-rich repeat ig PF00047.23 T179231_3 - 2e-09 37.4 0.7 3.4e-09 36.6 0.7 1.4 1 0 0 1 1 1 1 Immunoglobulin domain LRRNT PF01462.16 T179231_3 - 1.7e-05 24.2 3.1 8.2e-05 22.0 3.1 2.4 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain V-set PF07686.15 T179231_3 - 2.4e-05 24.3 1.6 0.00023 21.1 1.6 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T179231_3 - 5e-05 23.4 0.4 9.8e-05 22.5 0.4 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 T179231_3 - 0.067 13.6 24.1 4.5 8.0 0.0 6.9 6 2 0 6 6 6 0 Leucine Rich Repeat PARP PF00644.18 T119091_3 - 0.00035 20.1 0.0 0.00063 19.3 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PCNP PF15473.4 T247012_3 - 1.4e-63 214.2 7.6 2e-63 213.7 7.6 1.1 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family Gag_p30 PF02093.14 T366075_2 - 0.0058 16.0 0.0 0.0086 15.5 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein 7tm_4 PF13853.4 T366075_3 - 2.5e-54 184.8 21.3 3.5e-54 184.3 21.3 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T366075_3 - 5.4e-25 88.0 25.4 1.2e-24 86.9 25.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-CCHC PF00098.21 T366075_3 - 0.0056 16.6 1.0 0.012 15.6 1.0 1.6 1 0 0 1 1 1 1 Zinc knuckle ADK PF00406.20 T368012_1 - 3.5e-41 140.7 0.0 7.6e-25 87.6 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.4 T368012_1 - 6.1e-22 78.4 0.0 3.6e-10 40.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain Hydin_ADK PF17213.1 T368012_1 - 1.1e-15 58.4 0.1 2.8e-05 24.4 0.0 4.2 3 1 1 4 4 4 4 Hydin Adenylate kinase-like domain AAA_18 PF13238.4 T368012_1 - 2.3e-11 44.2 0.0 1.4e-06 28.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.4 T368012_1 - 1.7e-07 31.3 0.0 7.9e-05 22.7 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA PF00004.27 T368012_1 - 4.2e-07 30.3 0.0 0.029 14.7 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 T368012_1 - 2e-05 24.9 0.0 0.082 13.1 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.12 T368012_1 - 8.8e-05 22.4 0.0 0.49 10.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) SKI PF01202.20 T368012_1 - 0.00054 20.0 0.0 1.2 9.1 0.0 3.0 2 1 0 2 2 2 2 Shikimate kinase RuvB_N PF05496.10 T368012_1 - 0.0011 18.1 0.0 0.031 13.4 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus ABC_tran PF00005.25 T368012_1 - 0.0012 19.2 0.0 2.2 8.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_28 PF13521.4 T368012_1 - 0.0021 18.2 0.0 0.25 11.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.15 T368012_1 - 0.0026 17.3 0.1 10 5.6 0.0 3.5 2 1 1 3 3 3 0 Thymidylate kinase dNK PF01712.17 T368012_1 - 0.0033 17.2 0.0 0.75 9.5 0.0 2.5 2 1 0 2 2 2 1 Deoxynucleoside kinase KTI12 PF08433.8 T368012_1 - 0.0054 16.1 0.0 0.022 14.1 0.0 1.9 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_22 PF13401.4 T368012_1 - 0.0068 16.5 0.0 4.3 7.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.20 T368012_1 - 0.0096 16.2 0.0 0.86 9.9 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_29 PF13555.4 T368012_1 - 0.016 14.8 0.0 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain NACHT PF05729.10 T368012_1 - 0.02 14.7 0.0 0.83 9.4 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.4 T368012_1 - 0.022 14.3 0.0 2.2 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.16 T368012_1 - 0.027 14.1 0.0 1.8 8.1 0.0 2.3 2 0 0 2 2 2 0 Cytidylate kinase Mg_chelatase PF01078.19 T368012_1 - 0.036 13.3 0.0 9.2 5.5 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SRPRB PF09439.8 T368012_1 - 0.045 13.0 0.0 1.8 7.8 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit cobW PF02492.17 T368012_1 - 0.066 12.7 0.0 0.67 9.4 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain 6PF2K PF01591.16 T368012_1 - 0.079 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase IstB_IS21 PF01695.15 T368012_1 - 0.086 12.5 0.0 5.6 6.6 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activat PF00158.24 T368012_1 - 0.087 12.4 0.0 1.1 8.7 0.0 2.5 3 0 0 3 3 3 0 Sigma-54 interaction domain PPV_E1_C PF00519.15 T368012_1 - 0.14 10.8 0.0 0.32 9.6 0.0 1.5 2 0 0 2 2 2 0 Papillomavirus helicase AAA_14 PF13173.4 T368012_1 - 0.19 11.6 0.0 1.6 8.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain 7tm_1 PF00001.19 T153947_1 - 8.9e-10 38.1 2.8 1.9e-09 37.0 2.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 T153947_1 - 0.0058 15.8 0.9 0.093 11.9 0.1 2.1 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw Ion_trans PF00520.29 T234063_2 - 6.7e-118 392.2 41.7 2.2e-64 216.9 13.3 2.5 3 0 0 3 3 3 2 Ion transport protein PKD_channel PF08016.10 T234063_2 - 1.2e-13 50.4 35.9 1.9e-08 33.3 3.4 5.2 3 1 1 4 4 4 4 Polycystin cation channel Carn_acyltransf PF00755.18 T367323_3 - 2.2e-200 667.1 0.0 2.6e-200 666.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase C2 PF00168.28 T128205_3 - 7e-34 116.1 0.1 3.2e-20 72.2 0.0 2.2 2 0 0 2 2 2 2 C2 domain zf-C4 PF00105.16 T239238_2 - 5.6e-29 100.3 15.9 5.6e-29 100.3 15.9 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 T239238_2 - 4e-16 59.1 0.0 7e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Patatin PF01734.20 T234911_3 - 8.3e-14 52.1 0.0 1.4e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase GPS2_interact PF15784.3 T142469_2 - 5.7e-35 119.7 6.8 5.7e-35 119.7 6.8 4.3 3 0 0 3 3 3 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 T142469_2 - 1.1e-17 63.8 0.2 5.9e-12 45.4 0.2 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T142469_2 - 0.0066 16.5 1.9 0.091 12.9 0.3 2.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain zf-H2C2_2 PF13465.4 T080118_1 - 4.9e-13 48.8 47.1 1.9e-07 31.1 2.8 7.4 8 0 0 8 8 8 4 Zinc-finger double domain zf-C2H2 PF00096.24 T080118_1 - 9.8e-11 41.4 54.2 0.00025 21.2 1.3 7.2 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T080118_1 - 7.9e-06 26.1 52.5 0.0031 18.1 1.1 8.1 8 0 0 8 8 8 4 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T080118_1 - 0.003 17.2 30.5 0.0042 16.7 1.1 4.8 4 0 0 4 4 4 2 C2H2-type zinc-finger domain GAGA PF09237.9 T080118_1 - 0.15 11.8 2.4 0.51 10.1 0.1 2.4 1 1 1 2 2 2 0 GAGA factor zf-C2H2_11 PF16622.3 T080118_1 - 2.8 7.7 11.1 0.35 10.5 0.3 3.7 3 0 0 3 3 3 0 zinc-finger C2H2-type DUF1220 PF06758.11 T004081_2 - 1.3e-133 435.3 63.5 1.8e-28 98.5 1.8 7.3 7 0 0 7 7 7 6 Repeat of unknown function (DUF1220) GAT PF03127.12 T004081_2 - 0.0031 17.7 9.6 0.39 10.9 1.3 2.6 2 0 0 2 2 2 2 GAT domain HIP1_clath_bdg PF16515.3 T004081_2 - 9.1 6.8 17.2 11 6.6 9.6 3.0 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 BPL_LplA_LipB PF03099.17 T195135_2 - 0.0016 18.2 0.0 0.003 17.3 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family FGF PF00167.16 T062832_2 - 4.8e-34 117.0 0.0 7.3e-34 116.4 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Peptidase_C48 PF02902.17 T306810_2 - 6e-34 117.6 3.1 2.4e-20 73.2 1.3 2.4 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain KRAB PF01352.25 T176699_3 - 2.9e-13 49.1 0.6 5.4e-13 48.3 0.6 1.4 1 0 0 1 1 1 1 KRAB box Sterol-sensing PF12349.6 T322767_1 - 1.1e-16 60.9 3.4 1.7e-16 60.3 3.4 1.2 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.16 T322767_1 - 3.5e-13 48.4 2.9 4.6e-13 48.0 2.9 1.0 1 0 0 1 1 1 1 Patched family NPC1_N PF16414.3 T322767_2 - 1.6e-71 240.6 6.2 2.8e-71 239.8 6.2 1.4 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.16 T322767_3 - 1.9e-46 158.5 7.4 1.2e-29 102.9 6.4 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.6 T322767_3 - 6.1e-16 58.5 0.1 6.1e-16 58.5 0.1 2.3 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.17 T322767_3 - 2.5 5.5 9.0 3.4 5.1 9.0 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Gasdermin PF04598.10 T203762_1 - 2.4e-41 142.1 0.0 3.1e-41 141.7 0.0 1.1 1 0 0 1 1 1 1 Gasdermin family Tnp_zf-ribbon_2 PF13842.4 T203762_1 - 0.15 12.7 0.3 0.33 11.7 0.3 1.5 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon zf-C2H2 PF00096.24 T335318_1 - 1.3e-14 53.5 31.3 7e-07 29.2 0.7 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type KRAB PF01352.25 T335318_1 - 1.4e-12 46.9 2.6 1.4e-12 46.9 2.6 2.5 3 0 0 3 3 3 1 KRAB box zf-C2H2_4 PF13894.4 T335318_1 - 2.8e-10 40.0 31.0 0.0084 16.7 0.6 4.9 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T335318_1 - 4.5e-08 33.1 0.2 4.5e-08 33.1 0.2 6.5 7 0 0 7 7 7 3 Zinc-finger double domain zf-C2H2_6 PF13912.4 T335318_1 - 9e-07 28.6 26.4 0.0014 18.4 0.5 4.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 T335318_1 - 2.7e-05 24.3 26.5 0.0079 16.4 1.1 4.5 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T335318_1 - 8.6e-05 22.6 8.6 0.35 11.1 0.3 3.8 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.4 T335318_1 - 0.015 15.1 7.3 0.26 11.1 0.2 2.8 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_8 PF15909.3 T335318_1 - 1.1 9.5 11.9 3.9 7.7 0.4 3.4 2 1 1 3 3 3 0 C2H2-type zinc ribbon DUF3669 PF12417.6 T335318_2 - 2.3e-08 34.0 0.1 4.7e-08 33.0 0.1 1.6 1 0 0 1 1 1 1 Zinc finger protein DUF3715 PF12509.6 T036479_2 - 3.2e-59 199.1 13.6 4.1e-39 133.8 2.3 4.7 3 1 1 4 4 4 3 Protein of unknown function (DUF3715) DUF3699 PF12480.6 T036479_2 - 1.2e-28 98.9 0.2 4.3e-24 84.3 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF3699) DUF3884 PF13024.4 T036479_2 - 0.04 13.3 0.4 0.3 10.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3884) GPS PF01825.19 T133192_3 - 2.4e-13 50.4 1.2 8.4e-13 48.6 1.2 2.1 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HAP1_N PF04849.11 T240845_3 - 3.3e-112 374.6 48.0 5e-112 374.0 48.0 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Milton PF12448.6 T240845_3 - 1.7e-66 223.5 6.3 3e-66 222.7 6.3 1.4 1 0 0 1 1 1 1 Kinesin associated protein KASH_CCD PF14662.4 T240845_3 - 0.092 12.5 39.1 0.22 11.2 18.0 2.9 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH ZapB PF06005.10 T240845_3 - 1.3 9.4 34.4 0.86 10.0 9.6 3.6 3 0 0 3 3 3 0 Cell division protein ZapB Ribosomal_60s PF00428.17 T240845_3 - 8.2 6.9 6.1 19 5.7 6.1 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein CRIM PF16978.3 T366542_1 - 5.8e-35 120.3 0.0 9.7e-35 119.6 0.0 1.3 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.3 T366542_1 - 5.9e-31 106.9 0.3 9.7e-31 106.2 0.3 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology VPS9 PF02204.16 T366542_1 - 0.041 14.0 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 Vacuolar sorting protein 9 (VPS9) domain Copine PF07002.14 T217004_1 - 2e-84 282.3 0.0 3e-84 281.7 0.0 1.3 1 0 0 1 1 1 1 Copine C2 PF00168.28 T217004_1 - 3.8e-25 88.0 0.0 1.7e-12 47.4 0.0 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 T217004_1 - 2.2e-05 24.6 0.0 3.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus RRM_1 PF00076.20 T217004_3 - 8.3e-18 63.8 0.2 9.6e-07 28.4 0.1 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BTB PF00651.29 T226760_1 - 1.2e-24 86.5 0.2 2.1e-24 85.7 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 T226760_1 - 0.00024 21.3 44.4 0.047 14.0 3.5 7.1 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T226760_1 - 0.19 12.5 46.2 0.52 11.2 3.1 7.1 6 0 0 6 6 6 0 C2H2-type zinc finger zf-met PF12874.5 T226760_1 - 0.79 10.1 17.4 0.18 12.1 2.7 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 T226760_1 - 2.9 7.6 9.0 6.1 6.6 0.4 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type Ion_trans PF00520.29 T017087_1 - 1.6e-42 145.3 12.7 3.9e-42 144.0 12.7 1.7 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 T017087_1 - 6.3e-22 77.6 0.0 1e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Potassium_chann PF11404.6 T017087_1 - 7.6e-19 67.1 4.8 7.6e-19 67.1 4.8 2.7 2 0 0 2 2 2 1 Potassium voltage-gated channel Ion_trans_2 PF07885.14 T017087_1 - 2.1e-09 37.1 2.2 2.1e-09 37.1 2.2 1.9 2 0 0 2 2 2 1 Ion channel zf-C2H2_6 PF13912.4 T303681_2 - 1e-11 44.4 7.4 9.1e-05 22.2 0.2 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger ELM2 PF01448.22 T303681_2 - 1.7e-06 28.5 0.0 1.7e-06 28.5 0.0 3.0 3 0 0 3 3 3 1 ELM2 domain zf-C2H2_4 PF13894.4 T303681_2 - 3.2e-06 27.4 9.9 0.06 14.1 0.1 5.3 4 0 0 4 4 4 2 C2H2-type zinc finger Myb_DNA-binding PF00249.29 T303681_2 - 0.0013 18.7 0.1 0.0029 17.6 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-CW PF07496.13 T303681_2 - 0.016 15.1 0.3 0.016 15.1 0.3 2.0 2 0 0 2 2 2 0 CW-type Zinc Finger zf-C2H2_jaz PF12171.6 T303681_2 - 0.03 14.5 2.4 2.8 8.2 0.7 3.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 T303681_2 - 0.033 14.4 8.7 0.091 13.0 0.0 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.24 T303681_2 - 0.045 14.1 24.9 0.062 13.7 1.2 5.8 5 0 0 5 5 5 0 Zinc finger, C2H2 type Sigma70_ner PF04546.11 T303681_2 - 0.066 12.9 2.1 0.15 11.8 2.1 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region Myb_DNA-bind_7 PF15963.3 T303681_2 - 0.98 9.2 4.9 0.11 12.2 0.2 1.8 2 0 0 2 2 2 0 Myb DNA-binding like zf-C2H2 PF00096.24 T219982_2 - 8e-26 88.9 55.3 1.9e-05 24.7 0.4 8.3 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T219982_2 - 1e-19 69.9 42.7 1.4e-06 28.3 0.7 7.5 8 0 0 8 8 8 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 T219982_2 - 1.1e-17 63.1 63.3 0.003 18.1 0.3 9.4 8 0 0 8 8 8 7 C2H2-type zinc finger zf-met PF12874.5 T219982_2 - 1.8e-10 40.7 45.9 0.033 14.4 0.4 8.9 8 0 0 8 8 8 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T219982_2 - 6e-09 35.8 31.9 0.0065 16.6 2.2 7.4 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 T219982_2 - 0.00029 20.9 20.9 0.035 14.2 1.7 3.9 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding NinF PF05810.10 T219982_2 - 0.0018 18.0 1.5 0.011 15.5 0.7 2.3 2 0 0 2 2 2 1 NinF protein S8_pro-domain PF16470.3 T165661_2 - 3.6e-08 34.0 1.5 3.6e-08 34.0 1.5 2.4 3 0 0 3 3 3 1 Peptidase S8 pro-domain Peptidase_S8 PF00082.20 T165661_2 - 0.00014 21.1 0.0 0.0002 20.6 0.0 1.2 1 0 0 1 1 1 1 Subtilase family VSP PF03302.11 T165661_2 - 1.5 7.4 13.1 0.98 8.1 6.9 2.0 1 1 1 2 2 2 0 Giardia variant-specific surface protein Peptidase_S8 PF00082.20 T165661_3 - 1.6e-24 86.6 0.2 2.3e-24 86.0 0.2 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.18 T165661_3 - 7.1e-23 80.3 0.0 1.5e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain Mob1_phocein PF03637.15 T052758_1 - 2e-22 79.9 0.3 2.9e-22 79.4 0.3 1.1 1 0 0 1 1 1 1 Mob1/phocein family Mob1_phocein PF03637.15 T052758_2 - 8e-29 100.7 0.5 1.1e-28 100.2 0.5 1.1 1 0 0 1 1 1 1 Mob1/phocein family SecY PF00344.18 T037244_2 - 3.6e-43 147.8 1.8 5.7e-43 147.2 1.8 1.2 1 0 0 1 1 1 1 SecY translocase BEN PF10523.7 T160685_1 - 0.059 13.5 0.4 0.87 9.7 0.0 2.7 2 0 0 2 2 2 0 BEN domain Forkhead PF00250.16 T009132_3 - 6.2e-37 125.7 0.1 1.1e-36 124.9 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain TPR_2 PF07719.15 T240437_1 - 1.1e-05 25.0 3.6 0.75 9.9 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 T240437_1 - 0.013 16.1 0.1 1.1 10.1 0.1 3.7 1 1 3 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 T240437_1 - 0.02 14.8 0.0 0.09 12.7 0.0 2.1 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.4 T240437_1 - 0.051 14.0 0.1 86 3.6 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 T240437_1 - 0.052 13.3 8.5 5.4 6.9 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.4 T240437_1 - 0.063 13.4 2.3 8 6.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 T240437_1 - 0.1 12.2 0.1 0.31 10.6 0.0 1.9 2 0 0 2 2 2 0 TPR repeat Coatomer_E PF04733.12 T240437_1 - 0.19 10.9 0.6 15 4.7 0.0 2.2 2 0 0 2 2 2 0 Coatomer epsilon subunit TPR_19 PF14559.4 T240437_2 - 1.8e-20 73.1 11.2 8.2e-06 26.1 0.9 6.3 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.4 T240437_2 - 1.3e-15 56.6 0.2 0.039 14.6 0.0 7.2 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.15 T240437_2 - 2.7e-07 30.1 24.6 0.34 11.0 0.1 8.1 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_6 PF13174.4 T240437_2 - 2e-06 27.9 13.7 0.26 11.9 0.0 7.7 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_16 PF13432.4 T240437_2 - 7.2e-06 26.5 1.6 2.1 9.0 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.4 T240437_2 - 1.7e-05 24.2 8.1 0.14 11.7 0.0 4.4 3 1 1 4 4 4 3 TPR repeat TPR_12 PF13424.4 T240437_2 - 4.6e-05 23.5 5.6 4.4 7.5 0.3 5.8 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.26 T240437_2 - 6.8e-05 22.4 20.4 1.5 8.6 0.1 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.4 T240437_2 - 0.00025 21.1 0.4 9.3 6.8 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.4 T240437_2 - 0.017 14.2 3.8 2.1 7.3 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_21 PF09976.7 T240437_2 - 0.047 13.3 4.8 0.081 12.5 0.6 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_7 PF13176.4 T240437_2 - 0.055 13.4 8.1 2.4 8.2 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.5 T240437_2 - 0.14 12.2 20.8 0.74 9.9 2.7 5.0 3 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.4 T240437_2 - 0.26 11.4 10.1 5.7 7.3 0.1 5.9 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_19 PF14559.4 T240437_3 - 1.8e-15 57.0 13.5 2.6e-05 24.5 0.2 5.8 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.15 T240437_3 - 4e-13 48.2 11.9 0.0014 18.4 0.5 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.4 T240437_3 - 2e-12 47.4 1.3 0.0045 17.5 1.4 5.5 6 1 0 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.26 T240437_3 - 3.2e-12 45.6 17.4 0.00016 21.2 0.4 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat ANAPC3 PF12895.5 T240437_3 - 6.5e-12 45.4 5.4 0.00091 19.2 0.2 3.9 4 0 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.4 T240437_3 - 1.2e-11 44.3 4.4 0.38 11.6 0.1 7.4 5 1 1 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.4 T240437_3 - 7.4e-11 41.3 8.8 0.0075 16.3 0.4 5.8 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 T240437_3 - 2.4e-08 34.0 3.8 0.0073 16.4 0.6 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.4 T240437_3 - 2.5e-07 30.1 10.4 0.15 11.7 0.3 5.1 4 1 1 5 5 5 4 TPR repeat TPR_17 PF13431.4 T240437_3 - 0.0025 17.9 1.8 0.53 10.7 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.4 T240437_3 - 0.0054 16.5 8.5 1.6 8.8 0.6 5.4 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.4 T240437_3 - 0.0065 16.9 6.8 12 6.7 0.0 5.9 7 0 0 7 7 6 0 Tetratricopeptide repeat NARP1 PF12569.6 T240437_3 - 0.0099 14.7 5.7 0.39 9.4 1.3 2.9 3 1 1 4 4 4 3 NMDA receptor-regulated protein 1 TPR_9 PF13371.4 T240437_3 - 0.036 14.1 1.7 6.8 6.8 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat SRP_TPR_like PF17004.3 T240437_3 - 0.06 13.2 0.4 0.65 9.9 0.5 2.3 2 1 0 2 2 2 0 Putative TPR-like repeat TPR_10 PF13374.4 T240437_3 - 8 6.4 9.3 1e+02 2.8 0.5 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF498 PF04430.12 T064547_3 - 2.3e-16 59.7 0.0 5.3e-16 58.5 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) RINGv PF12906.5 T273917_2 - 5.7e-15 55.0 16.4 1.7e-14 53.6 16.4 1.9 1 0 0 1 1 1 1 RING-variant domain DUF4556 PF15094.4 T002996_1 - 2.9e-74 248.9 0.0 4.2e-74 248.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4556) DUF3371 PF11851.6 T331612_1 - 2.7e-30 105.9 2.9 6.2e-30 104.7 2.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3371) HLH PF00010.24 T331612_1 - 2.8e-15 55.9 0.9 8.5e-15 54.3 0.3 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain MITF_TFEB_C_3_N PF15951.3 T331612_1 - 0.0015 19.1 1.3 0.0015 19.1 1.3 1.7 2 0 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus RWD PF05773.20 T310265_1 - 5.4e-21 74.9 1.0 1e-20 74.0 1.0 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.3 T310265_1 - 1.5e-05 25.2 5.9 1.5e-05 25.2 5.9 2.2 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 BUD22 PF09073.8 T310265_1 - 2.5 7.2 11.8 3.5 6.7 11.8 1.1 1 0 0 1 1 1 0 BUD22 Radial_spoke PF04712.10 T310265_2 - 5e-204 678.7 8.3 8.7e-204 677.9 8.3 1.4 1 0 0 1 1 1 1 Radial spokehead-like protein Snf7 PF03357.19 T340510_3 - 1.1e-22 80.3 6.6 3.1e-22 78.9 6.0 1.8 2 0 0 2 2 2 1 Snf7 PspA_IM30 PF04012.10 T340510_3 - 4.5e-05 23.0 3.1 8.2e-05 22.1 3.1 1.3 1 0 0 1 1 1 1 PspA/IM30 family Fez1 PF06818.13 T340510_3 - 0.21 11.9 4.2 0.38 11.0 4.2 1.3 1 0 0 1 1 1 0 Fez1 LPP PF04728.11 T340510_3 - 0.58 10.4 1.5 1.5 9.1 0.2 2.1 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Methyltransf_16 PF10294.7 T126961_1 - 1.6e-13 50.7 0.3 2.1e-12 47.0 0.3 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Aminotran_3 PF00202.19 T126961_3 - 4.7e-141 470.0 0.0 5.9e-141 469.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III RRM_1 PF00076.20 T013036_2 - 3.2e-06 26.8 0.0 7.8e-06 25.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PS_Dcarbxylase PF02666.13 T232393_3 - 1.4e-67 227.0 0.0 1.8e-67 226.7 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Copine PF07002.14 T138713_1 - 2.9e-43 147.7 0.0 3.8e-43 147.3 0.0 1.1 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.7 T138713_1 - 0.042 13.8 0.0 0.062 13.3 0.0 1.1 1 0 0 1 1 1 0 vWA found in TerF C terminus VWA PF00092.26 T138713_1 - 0.064 13.4 0.0 0.094 12.8 0.0 1.1 1 0 0 1 1 1 0 von Willebrand factor type A domain C2 PF00168.28 T138713_2 - 3.9e-11 43.0 0.0 6.7e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 C2 domain Copine PF07002.14 T138713_3 - 7.9e-43 146.3 0.0 1.1e-42 145.9 0.0 1.1 1 0 0 1 1 1 1 Copine C2 PF00168.28 T138713_3 - 8.9e-15 54.7 0.0 1.7e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 C2 domain VIT PF08487.8 T375214_2 - 1.4e-30 105.7 0.8 2.3e-30 105.0 0.8 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.4 T375214_2 - 0.11 12.2 0.1 0.29 10.9 0.1 1.6 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain Filaggrin PF03516.11 T021098_1 - 1.1e-156 509.5 1129.3 7.4e-17 61.7 34.1 44.0 26 12 15 42 42 42 26 Filaggrin DND1_DSRM PF14709.5 T021098_1 - 0.0002 21.4 0.2 4.9e+02 1.0 0.0 8.5 10 0 0 10 10 10 0 double strand RNA binding domain from DEAD END PROTEIN 1 S_100 PF01023.17 T021098_2 - 5.1e-15 54.8 3.8 1.1e-14 53.7 3.8 1.6 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain Filaggrin PF03516.11 T021098_2 - 7.3e-11 42.5 16.9 7.3e-11 42.5 16.9 4.9 5 1 0 5 5 5 1 Filaggrin EF-hand_7 PF13499.4 T021098_2 - 0.00029 21.1 2.1 0.00073 19.8 2.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair DUF4574 PF15141.4 T021098_2 - 0.078 12.8 0.0 33 4.3 0.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4574) EF-hand_1 PF00036.30 T021098_2 - 0.087 12.3 4.3 0.065 12.7 1.8 2.1 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.4 T021098_2 - 0.27 11.1 4.2 5.8 7.0 0.8 3.0 2 0 0 2 2 2 0 EF-hand domain HTH_1 PF00126.25 T021098_3 - 2.6e-08 33.6 4.9 11 5.9 0.0 6.4 6 0 0 6 6 6 3 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.18 T021098_3 - 1.7e-07 30.8 0.6 17 5.2 0.0 6.3 6 0 0 6 6 6 3 Bacterial regulatory protein, arsR family HTH_IclR PF09339.8 T021098_3 - 6.6e-05 22.5 4.7 48 3.7 0.0 6.2 6 0 0 6 6 6 0 IclR helix-turn-helix domain Basic PF01586.14 T021098_3 - 0.0026 18.8 30.8 10 7.2 0.3 6.4 6 0 0 6 6 6 5 Myogenic Basic domain Flavi_M PF01004.17 T021098_3 - 0.013 15.1 3.0 11 5.7 0.0 4.3 4 0 0 4 4 4 0 Flavivirus envelope glycoprotein M DUF4819 PF16090.3 T176215_2 - 3.8e-21 74.7 0.1 7.6e-21 73.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4819) HMG_box PF00505.17 T176215_2 - 8.2e-17 61.3 1.5 1.6e-16 60.3 1.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T176215_2 - 3.8e-07 30.5 0.4 8.9e-07 29.3 0.4 1.6 1 0 0 1 1 1 1 HMG-box domain DuoxA PF10204.7 T115872_1 - 1.2e-111 372.0 6.1 1.8e-111 371.5 6.1 1.2 1 0 0 1 1 1 1 Dual oxidase maturation factor Xlink PF00193.15 T170875_2 - 6e-60 199.5 0.1 1.3e-29 102.3 0.0 3.0 3 0 0 3 3 3 2 Extracellular link domain V-set PF07686.15 T170875_2 - 5.5e-10 39.2 0.0 1e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain EGF PF00008.25 T170875_2 - 1.2e-08 34.9 32.6 1.4e-05 25.2 11.6 3.1 3 0 0 3 3 3 2 EGF-like domain Lectin_C PF00059.19 T170875_2 - 1.4e-06 28.8 0.3 0.0006 20.4 0.0 3.3 3 0 0 3 3 3 1 Lectin C-type domain hEGF PF12661.5 T170875_2 - 1.7e-05 25.2 4.3 1.7e-05 25.2 4.3 5.1 4 0 0 4 4 4 2 Human growth factor-like EGF Ig_3 PF13927.4 T170875_2 - 0.06 13.8 0.0 0.19 12.2 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin domain EGF_2 PF07974.11 T170875_2 - 0.11 12.7 34.7 0.27 11.5 12.9 3.4 3 0 0 3 3 3 0 EGF-like domain MH2 PF03166.12 T162255_1 - 5.9e-18 65.6 0.1 9e-18 65.0 0.1 1.2 1 0 0 1 1 1 1 MH2 domain MH2 PF03166.12 T162255_2 - 1.7e-53 181.5 0.0 2.5e-53 180.9 0.0 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 T162255_2 - 3.6e-39 133.0 0.5 7.6e-39 131.9 0.5 1.6 1 0 0 1 1 1 1 MH1 domain Lactamase_B_4 PF13691.4 T162255_3 - 0.055 13.0 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 tRNase Z endonuclease zf-C2H2 PF00096.24 T068593_1 - 1.1e-11 44.4 51.9 0.00027 21.1 5.8 6.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T068593_1 - 2.5e-06 27.7 52.2 0.00025 21.5 2.3 6.3 6 0 0 6 6 6 4 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T068593_1 - 7.4e-06 26.1 49.3 0.025 14.9 5.1 6.5 6 0 0 6 6 6 4 Zinc-finger double domain zf-met PF12874.5 T068593_1 - 0.0012 19.0 28.6 0.19 12.0 0.2 5.2 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 T068593_1 - 0.0046 16.7 3.2 0.0046 16.7 3.2 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T068593_1 - 0.019 15.2 26.6 0.091 13.0 1.4 4.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Actin_micro PF17003.3 T068593_1 - 0.037 13.1 0.1 0.037 13.1 0.1 2.8 2 1 0 2 2 2 0 Putative actin-like family SLIDE PF09111.8 T068593_1 - 0.083 12.8 0.0 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 SLIDE zf-Di19 PF05605.10 T068593_1 - 1.9 8.7 29.8 0.048 13.8 8.8 3.1 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.3 T068593_1 - 8.3 6.8 21.1 0.24 11.8 3.7 3.4 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_2 PF13465.4 T068593_3 - 7.4e-05 22.9 1.5 0.0001 22.5 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.4 T068593_3 - 0.00023 21.6 6.8 0.63 10.9 0.0 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.24 T068593_3 - 0.00086 19.5 8.1 0.077 13.4 2.4 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type FOXP-CC PF16159.3 T068593_3 - 0.066 13.7 3.1 6.2 7.4 0.7 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain GRIP PF01465.18 T240185_3 - 2.2e-09 36.9 0.1 2.2e-09 36.9 0.1 3.0 3 0 0 3 3 3 1 GRIP domain DUF4680 PF15730.3 T070713_2 - 0.35 11.1 3.2 0.7 10.1 3.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) IL3 PF02059.13 T288808_1 - 4.3e-07 29.9 0.4 7.6e-07 29.1 0.0 1.5 2 0 0 2 2 2 1 Interleukin-3 Frag1 PF10277.7 T017299_1 - 1.7e-31 109.3 7.8 2.8e-31 108.6 7.8 1.3 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Frag1 PF10277.7 T017299_3 - 5.7e-13 48.8 1.8 1.4e-12 47.5 1.8 1.7 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family TSP_1 PF00090.17 T121013_2 - 3.8e-47 158.1 152.1 1.4e-07 31.4 2.8 14.6 13 1 0 13 13 13 12 Thrombospondin type 1 domain Ig_3 PF13927.4 T121013_2 - 1.8e-28 98.8 0.5 3.8e-12 46.5 0.0 4.0 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T121013_2 - 3.8e-27 94.0 0.0 2.8e-12 46.4 0.0 4.0 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 T121013_2 - 1.6e-18 66.7 0.1 1.1e-06 28.7 0.0 4.1 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T121013_2 - 3.4e-14 52.6 0.1 7.8e-09 35.5 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 T121013_2 - 8.3e-10 38.7 0.2 0.22 11.5 0.0 5.0 3 2 1 4 4 4 3 Immunoglobulin V-set domain PLAC PF08686.9 T121013_2 - 2.4e-08 34.4 16.3 2.7e-08 34.3 13.7 2.6 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain zf-H2C2_2 PF13465.4 T182472_3 - 4.6e-48 159.5 62.6 3.9e-09 36.4 0.8 11.9 13 0 0 13 13 12 8 Zinc-finger double domain zf-C2H2 PF00096.24 T182472_3 - 1.4e-40 135.4 58.6 8.5e-07 29.0 0.5 10.8 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T182472_3 - 3.1e-24 83.4 58.5 0.00085 19.8 0.5 10.8 10 0 0 10 10 10 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T182472_3 - 1.4e-06 28.2 52.7 0.017 15.1 4.5 7.5 4 1 3 8 8 8 5 Zinc ribbon domain zf-C2H2_6 PF13912.4 T182472_3 - 0.0001 22.0 55.1 0.63 9.9 1.9 9.8 10 0 0 10 10 10 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T182472_3 - 0.00038 20.5 20.3 0.44 10.8 0.0 7.1 8 0 0 8 8 8 3 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 T182472_3 - 0.0024 18.0 1.1 0.0024 18.0 1.1 4.4 3 2 1 5 5 5 1 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.3 T182472_3 - 3.3 8.4 29.7 3.4 8.3 2.2 5.9 1 1 5 6 6 6 0 zinc-ribbon family zf-C2H2_11 PF16622.3 T182472_3 - 4.6 7.0 30.8 2.9 7.6 1.9 6.7 6 0 0 6 6 6 0 zinc-finger C2H2-type SprT-like PF10263.7 T182472_3 - 6.8 6.4 35.6 1 9.1 4.0 5.3 3 3 1 4 4 4 0 SprT-like family zinc_ribbon_9 PF14369.4 T182472_3 - 8.7 6.6 28.0 13 6.0 0.1 7.8 6 2 1 7 7 7 0 zinc-ribbon AMP-binding PF00501.26 T128402_1 - 1e-05 24.2 0.0 1.3e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 T128402_2 - 5.2e-26 91.3 0.7 7.8e-26 90.7 0.7 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.26 T128402_2 - 2.1e-10 39.6 0.0 2.9e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme SRI PF08236.9 T128402_2 - 0.00071 19.6 0.7 0.001 19.0 0.7 1.2 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain Cu_amine_oxid PF01179.18 T335843_1 - 1.4e-118 396.2 0.1 2.1e-118 395.7 0.1 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.14 T335843_1 - 5.1e-31 106.6 0.0 1.1e-30 105.6 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.14 T335843_1 - 1.9e-20 73.0 0.0 3.5e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain DUF1965 PF09248.8 T335843_1 - 0.00026 20.6 0.0 0.00066 19.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) APOBEC_C PF05240.12 T233899_2 - 1.5e-08 34.3 0.1 2.2e-08 33.8 0.1 1.2 1 0 0 1 1 1 1 APOBEC-like C-terminal domain APOBEC_N PF08210.9 T233899_3 - 1.5e-24 86.7 0.4 2.1e-24 86.3 0.4 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 T233899_3 - 6.3e-10 38.7 0.0 1.1e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 T233899_3 - 0.00019 21.1 0.4 0.00032 20.4 0.4 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region zf-H2C2_2 PF13465.4 T040248_1 - 5.5e-99 320.4 136.6 1.9e-08 34.2 2.2 18.7 18 0 0 18 18 18 16 Zinc-finger double domain zf-C2H2 PF00096.24 T040248_1 - 1.3e-74 242.5 154.5 3.4e-05 23.9 0.6 18.7 17 0 0 17 17 17 17 Zinc finger, C2H2 type KRAB PF01352.25 T040248_1 - 4.3e-25 87.0 0.2 9e-25 86.0 0.2 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T040248_1 - 3.4e-22 77.1 154.7 0.057 14.1 2.8 19.4 18 0 0 18 18 18 15 C2H2-type zinc finger BolA PF01722.16 T040248_1 - 2 8.6 18.9 1.6 9.0 0.2 5.8 5 1 0 5 5 5 0 BolA-like protein RVT_1 PF00078.25 T040248_3 - 0.057 12.8 0.1 0.097 12.0 0.1 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) HMG_box_5 PF14887.4 T148536_1 - 1e-55 185.5 39.1 9.1e-53 176.1 7.3 5.5 4 1 1 5 5 5 3 HMG (high mobility group) box 5 HMG_box PF00505.17 T148536_1 - 3.4e-51 171.4 68.9 1.4e-17 63.7 7.5 7.5 7 1 1 8 8 8 6 HMG (high mobility group) box HMG_box_2 PF09011.8 T148536_1 - 2.7e-26 91.8 56.3 5.9e-08 33.1 0.2 7.1 6 1 1 7 7 7 6 HMG-box domain DUF4473 PF14747.4 T148536_1 - 0.003 17.9 0.5 0.003 17.9 0.5 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4473) DUF863 PF05904.9 T302146_1 - 1.1 7.5 6.5 1.4 7.1 6.5 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF863) Aminotran_5 PF00266.17 T211405_2 - 3.5e-69 233.4 0.0 4.3e-69 233.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Tetraspannin PF00335.18 T072366_2 - 2.6e-43 148.2 10.5 2.6e-43 148.2 10.5 2.4 3 0 0 3 3 3 1 Tetraspanin family zf-C2H2 PF00096.24 T035111_2 - 4.3e-18 64.5 23.3 0.00014 21.9 0.6 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T035111_2 - 8.9e-13 47.9 23.8 1e-05 25.6 0.3 4.7 3 1 1 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 T035111_2 - 3.5e-10 39.7 23.3 0.015 15.9 1.9 4.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_8 PF15909.3 T035111_2 - 0.00043 20.4 5.5 0.00043 20.4 5.5 2.4 1 1 2 3 3 3 2 C2H2-type zinc ribbon zf-met PF12874.5 T035111_2 - 0.014 15.6 14.8 0.36 11.1 0.1 4.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-Sec23_Sec24 PF04810.13 T035111_2 - 0.017 15.0 4.5 9.1 6.3 0.1 3.7 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-C2H2_jaz PF12171.6 T035111_2 - 0.066 13.4 13.2 0.091 13.0 0.1 3.8 4 0 0 4 4 3 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 T035111_2 - 0.081 12.8 6.6 3.4 7.6 0.0 3.6 1 1 2 3 3 3 0 CpXC protein zf-C2HC_2 PF13913.4 T035111_2 - 0.16 11.7 22.9 0.12 12.2 1.2 5.2 5 0 0 5 5 5 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.4 T035111_2 - 0.31 10.9 14.6 1.7 8.5 0.2 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-TRAF PF02176.16 T035111_2 - 1.5 9.4 14.0 0.17 12.5 4.0 2.6 2 0 0 2 2 2 0 TRAF-type zinc finger Zn-ribbon_8 PF09723.8 T035111_2 - 2.3 8.3 15.5 2.4 8.2 2.1 3.6 3 1 0 3 3 3 0 Zinc ribbon domain C1_4 PF07975.10 T035111_2 - 7.1 6.8 12.3 6.9 6.9 2.8 2.6 2 0 0 2 2 2 0 TFIIH C1-like domain Myb_DNA-bind_7 PF15963.3 T125045_1 - 0.033 13.9 0.1 0.064 13.0 0.1 1.4 1 0 0 1 1 1 0 Myb DNA-binding like Myb_DNA-binding PF00249.29 T125045_1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Jnk-SapK_ap_N PF09744.7 T125045_2 - 5.5e-56 189.0 23.9 5.5e-56 189.0 23.9 2.6 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 JIP_LZII PF16471.3 T125045_2 - 4.4e-28 97.1 9.3 4.4e-28 97.1 9.3 2.8 3 1 0 3 3 3 1 JNK-interacting protein leucine zipper II JUPITER PF17054.3 T125045_2 - 1.5e-08 34.4 1.5 9.4e-06 25.2 0.1 2.6 3 0 0 3 3 3 2 Microtubule-Associated protein Jupiter Rootletin PF15035.4 T125045_2 - 0.0013 18.7 1.7 0.0013 18.7 1.7 2.8 2 1 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion Atg14 PF10186.7 T125045_2 - 0.091 11.7 25.8 0.088 11.7 10.5 2.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ERM PF00769.17 T125045_2 - 1.4 8.6 28.5 2.4 7.8 8.3 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family 4HBT PF03061.20 T285005_1 - 1.2e-23 83.1 1.2 1.6e-10 41.1 0.1 2.3 2 0 0 2 2 2 2 Thioesterase superfamily START PF01852.17 T285005_2 - 2.5e-07 30.2 0.1 4.2e-07 29.5 0.1 1.2 1 0 0 1 1 1 1 START domain CDC45 PF02724.12 T178333_1 - 0.026 12.7 15.7 0.038 12.2 15.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.15 T178333_1 - 0.64 10.0 6.3 1.1 9.2 6.3 1.3 1 0 0 1 1 1 0 DDHD domain Borrelia_P83 PF05262.9 T178333_1 - 2.2 6.6 17.1 3 6.1 17.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Presenilin PF01080.15 T178333_2 - 4.2 5.9 13.3 7.8 5.0 13.3 1.3 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.12 T178333_2 - 9.7 4.2 20.5 15 3.6 20.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Glyco_transf_11 PF01531.14 T178333_3 - 4.1e-145 482.4 0.0 5.4e-145 482.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 11 DnaJ PF00226.29 T345183_2 - 3.2e-26 91.1 1.0 5.4e-26 90.4 1.0 1.4 1 0 0 1 1 1 1 DnaJ domain TTL PF03133.13 T000510_2 - 9.2e-44 149.6 0.0 1.3e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 T000510_2 - 3.5e-11 42.7 0.0 4.6e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 T000510_2 - 0.0088 15.2 0.0 0.27 10.3 0.0 2.1 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp ThiF PF00899.19 T250757_3 - 1e-40 139.6 1.6 5.9e-32 110.8 0.0 2.2 2 0 0 2 2 2 2 ThiF family Pox_A_type_inc PF04508.10 T250757_3 - 0.14 11.9 2.6 0.37 10.6 2.6 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat MMtag PF10159.7 T032097_1 - 9.4e-30 102.6 0.2 9.4e-30 102.6 0.2 2.1 2 0 0 2 2 2 1 Kinase phosphorylation protein DUF3987 PF13148.4 T032097_1 - 0.31 9.8 2.7 0.45 9.3 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Presenilin PF01080.15 T032097_1 - 0.59 8.7 4.7 0.86 8.1 4.7 1.1 1 0 0 1 1 1 0 Presenilin MIP-T3 PF10243.7 T032097_1 - 1.7 7.1 18.6 2.3 6.7 18.6 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1510 PF07423.9 T032097_1 - 3.3 7.0 7.7 5.4 6.3 7.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RR_TM4-6 PF06459.10 T032097_1 - 4 7.0 11.3 5.9 6.5 11.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Med19 PF10278.7 T032097_1 - 7.2 6.4 18.4 12 5.6 18.4 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SRP-alpha_N PF04086.11 T032097_1 - 9.4 5.9 17.1 13 5.4 17.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Mitoc_L55 PF09776.7 T032097_2 - 1.7e-52 175.9 3.5 1.7e-52 175.9 3.5 1.8 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L55 7tm_1 PF00001.19 T334045_2 - 1.1e-71 241.0 5.3 1.1e-71 241.0 5.3 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) ODC_AZ PF02100.15 T020955_3 - 2.1e-15 56.6 0.0 3.1e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme DHR-2 PF06920.11 T168451_3 - 9.9e-214 710.7 0.0 1.4e-213 710.2 0.0 1.2 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.4 T168451_3 - 9.7e-48 162.4 0.0 1.6e-47 161.7 0.0 1.4 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Ank_2 PF12796.5 T168451_3 - 3.3e-25 88.3 4.3 5.2e-16 58.9 0.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) DUF3398 PF11878.6 T168451_3 - 4e-24 84.7 0.0 1.6e-23 82.8 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3398) KN_motif PF12075.6 T168451_3 - 3.4e-22 77.8 1.8 9.7e-22 76.3 1.8 1.9 1 0 0 1 1 1 1 KN motif Ank_3 PF13606.4 T168451_3 - 2e-17 61.4 0.3 0.0001 22.3 0.0 5.0 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.28 T168451_3 - 6.4e-17 61.0 2.6 4.7e-05 23.5 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.4 T168451_3 - 9.8e-16 57.8 0.4 1.3e-08 35.0 0.1 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 T168451_3 - 1.5e-14 53.8 2.2 9.5e-07 28.9 0.2 4.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) DOCK_N PF16172.3 T168451_3 - 0.096 11.4 0.2 0.3 9.8 0.0 1.8 2 0 0 2 2 2 0 DOCK N-terminus NAM-associated PF14303.4 T168451_3 - 0.22 12.1 0.6 0.77 10.3 0.6 1.9 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain ARGLU PF15346.4 T098631_1 - 2e-23 82.8 23.8 3.1e-23 82.2 23.8 1.2 1 0 0 1 1 1 1 Arginine and glutamate-rich 1 ARGLU PF15346.4 T098631_2 - 1.8e-19 70.0 29.3 1.8e-19 70.0 29.3 3.0 1 1 1 2 2 2 1 Arginine and glutamate-rich 1 RhoGAP PF00620.25 T233407_2 - 2.6e-44 150.6 0.0 6.3e-44 149.3 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain BAR PF03114.16 T233407_2 - 1.8e-35 122.6 6.3 2.5e-35 122.1 6.3 1.2 1 0 0 1 1 1 1 BAR domain DUF2046 PF09755.7 T233407_2 - 0.00095 18.4 1.2 0.002 17.3 1.2 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) BAR_2 PF10455.7 T233407_2 - 0.073 12.1 2.3 0.11 11.5 2.3 1.2 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Ribosomal_60s PF00428.17 T233407_2 - 0.13 12.6 1.9 1.2 9.6 1.3 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4890 PF16231.3 T233407_2 - 0.77 10.1 2.8 1.5 9.2 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4890) BAR_3 PF16746.3 T233407_2 - 0.95 9.0 6.7 0.079 12.5 1.3 1.8 2 0 0 2 2 2 0 BAR domain of APPL family FlgN PF05130.10 T233407_2 - 1 9.7 5.3 0.89 9.9 2.6 2.3 2 0 0 2 2 2 0 FlgN protein CcmD PF04995.12 T041953_1 - 0.95 9.5 7.9 6.8 6.7 0.5 3.0 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) BIR PF00653.19 T283891_1 - 1.8e-54 182.2 7.6 5.6e-20 71.7 1.3 3.7 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain NACHT PF05729.10 T283891_1 - 4.9e-38 130.5 0.1 8.5e-38 129.7 0.1 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.20 T283891_1 - 3.6e-05 22.8 0.0 5.9e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_30 PF13604.4 T283891_1 - 0.026 14.1 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.4 T283891_1 - 0.053 13.7 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_pol_N PF01194.15 T283891_1 - 0.1 12.7 2.4 7.8 6.7 0.3 2.8 2 0 0 2 2 2 0 RNA polymerases N / 8 kDa subunit DUF2075 PF09848.7 T283891_1 - 0.15 11.1 0.0 0.29 10.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) LRR_4 PF12799.5 T283891_3 - 0.0011 19.2 9.8 0.067 13.5 0.1 5.2 3 2 3 6 6 6 2 Leucine Rich repeats (2 copies) SPA PF08616.8 T236359_1 - 1.3e-11 44.3 0.0 2e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Stabilization of polarity axis Plexin_cytopl PF08337.10 T236359_3 - 1.8e-222 739.8 3.5 2.7e-222 739.2 3.5 1.2 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.17 T236359_3 - 6.8e-62 209.5 0.0 9.5e-62 209.0 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 T236359_3 - 4.2e-38 129.2 4.3 2.4e-11 43.4 0.0 5.8 5 0 0 5 5 5 4 IPT/TIG domain PSI PF01437.23 T236359_3 - 3.5e-13 49.7 47.3 2e-08 34.5 16.1 4.2 3 0 0 3 3 3 3 Plexin repeat Peptidase_S64 PF08192.9 T236359_3 - 0.0038 15.7 0.5 0.0058 15.1 0.5 1.1 1 0 0 1 1 1 1 Peptidase family S64 RasGAP PF00616.17 T236359_3 - 0.015 14.8 0.3 0.04 13.5 0.0 1.7 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase DENN PF02141.19 T236359_3 - 0.073 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 DENN (AEX-3) domain HAP1_N PF04849.11 T147521_1 - 0.00032 19.9 2.3 0.00052 19.2 2.3 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region HAP1_N PF04849.11 T147521_3 - 5.3e-78 262.2 33.1 7.3e-78 261.8 33.1 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region NOA36 PF06524.10 T147521_3 - 0.35 10.1 6.4 0.56 9.4 6.4 1.2 1 0 0 1 1 1 0 NOA36 protein BSP_II PF05432.9 T147521_3 - 4.1 6.9 14.7 6.4 6.3 14.7 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) bZIP_1 PF00170.19 T147521_3 - 8.8 6.4 17.6 0.12 12.3 3.1 3.2 3 0 0 3 3 3 0 bZIP transcription factor Dicty_REP PF05086.10 T147521_3 - 9.1 4.0 9.9 13 3.5 9.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein LEAP-2 PF07359.9 T288982_2 - 4.5e-42 141.6 3.0 9.5e-42 140.6 3.0 1.6 1 0 0 1 1 1 1 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) UcrQ PF02939.14 T288982_2 - 1.7e-29 101.4 0.2 2.7e-29 100.8 0.2 1.3 1 0 0 1 1 1 1 UcrQ family EB PF01683.16 T288982_2 - 0.75 10.0 6.2 0.31 11.2 0.2 3.0 2 0 0 2 2 2 0 EB module Ifi-6-16 PF06140.11 T109368_1 - 2.9e-20 71.8 19.6 2.9e-20 71.8 19.6 2.5 2 0 0 2 2 2 2 Interferon-induced 6-16 family Ifi-6-16 PF06140.11 T109368_2 - 8.4e-27 92.8 26.0 8.4e-27 92.8 26.0 2.2 2 0 0 2 2 2 1 Interferon-induced 6-16 family Pkinase PF00069.23 T180604_1 - 1.1e-50 172.3 0.0 1.3e-50 172.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T180604_1 - 2.6e-28 98.9 0.0 3.5e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 T180604_1 - 8.1e-07 29.5 0.3 1.8e-06 28.4 0.3 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 T180604_1 - 0.05 12.8 0.0 0.08 12.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.21 T180604_1 - 0.078 12.8 0.2 0.25 11.1 0.1 1.9 2 1 0 2 2 2 0 Phosphotransferase enzyme family PH PF00169.27 T199350_2 - 8.1e-09 35.8 0.5 1.6e-08 34.8 0.5 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 T199350_2 - 0.0026 18.0 0.2 0.0048 17.2 0.2 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain V-set PF07686.15 T153989_1 - 5.1e-12 45.8 0.0 1.4e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain SIT PF15330.4 T153989_1 - 6.2e-11 42.6 0.1 1.3e-10 41.6 0.1 1.5 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT ig PF00047.23 T153989_1 - 0.0014 18.6 0.0 0.0059 16.6 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin domain Thyroglobulin_1 PF00086.16 T207346_1 - 6.8e-18 64.0 2.5 1.3e-17 63.0 2.5 1.5 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat DUF3844 PF12955.5 T207346_2 - 0.31 11.1 1.6 0.66 10.0 1.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) p450 PF00067.20 T080769_1 - 1.7e-23 83.0 0.0 2.3e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_4 PF02390.15 T080769_2 - 2.4e-57 193.0 0.0 3.2e-57 192.6 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.4 T080769_2 - 0.16 12.6 0.0 0.26 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain p450 PF00067.20 T080769_3 - 1.1e-59 202.3 0.0 1.4e-59 202.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.19 T094413_2 - 3e-39 134.8 21.3 4.7e-39 134.1 21.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 T094413_2 - 0.00012 21.1 22.2 0.00023 20.2 22.2 1.4 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 T024619_1 - 2.2e-44 151.6 17.9 3.9e-44 150.8 17.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 T024619_1 - 0.0015 17.8 15.2 0.0015 17.8 15.2 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MBOAT PF03062.17 T240999_3 - 9.2e-08 31.7 1.1 1.4e-07 31.1 1.1 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family RIIa PF02197.15 T168863_1 - 0.034 13.7 0.0 4.8 6.8 0.0 2.6 2 0 0 2 2 2 0 Regulatory subunit of type II PKA R-subunit zf-H2C2_2 PF13465.4 T168863_2 - 4.1e-87 282.9 126.7 7.5e-08 32.4 2.6 17.7 16 0 0 16 16 16 16 Zinc-finger double domain zf-C2H2 PF00096.24 T168863_2 - 4.4e-44 146.4 125.3 8.1e-05 22.7 0.1 16.3 15 0 0 15 15 15 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T168863_2 - 1.7e-31 106.0 126.4 0.0053 17.4 1.2 17.2 16 0 0 16 16 16 14 C2H2-type zinc finger KRAB PF01352.25 T168863_2 - 3.8e-20 71.1 0.0 8.8e-20 70.0 0.0 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T168863_2 - 5.8e-12 45.1 91.1 0.0038 17.0 1.2 15.4 15 0 0 15 15 15 10 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T168863_2 - 0.003 17.2 0.0 0.003 17.2 0.0 10.4 11 0 0 11 11 11 4 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 T168863_2 - 0.016 15.4 78.2 0.037 14.2 0.1 14.0 15 0 0 15 15 15 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.4 T168863_3 - 9.6e-73 237.5 139.3 1.1e-07 31.8 1.5 15.8 15 0 0 15 15 15 14 Zinc-finger double domain zf-C2H2 PF00096.24 T168863_3 - 6.7e-29 98.6 136.0 0.00068 19.8 0.9 16.9 16 0 0 16 16 16 15 Zinc finger, C2H2 type KRAB PF01352.25 T168863_3 - 1.1e-23 82.4 0.3 2.2e-23 81.5 0.3 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T168863_3 - 5.6e-21 73.3 129.3 0.021 15.5 0.8 17.5 16 0 0 16 16 16 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T168863_3 - 8.4e-09 35.0 99.6 0.0016 18.2 3.5 14.7 14 0 0 14 14 14 10 C2H2-type zinc finger zf-trcl PF13451.4 T168863_3 - 0.00011 21.9 69.2 0.037 13.8 0.1 10.3 7 4 3 10 10 10 5 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.8 T168863_3 - 0.022 14.8 88.8 0.04 13.9 2.0 10.1 1 1 12 13 13 13 0 Zinc ribbon domain AMP-binding PF00501.26 T182579_1 - 2.8e-16 59.0 0.0 4.5e-07 28.7 0.0 2.9 2 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.4 T182579_3 - 4.3e-08 33.9 0.0 7.2e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 2OG-FeII_Oxy_2 PF13532.4 T174181_1 - 1.3e-12 48.2 0.0 3.4e-12 46.9 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CAP_GLY PF01302.23 T174181_3 - 5.8e-48 160.6 3.2 5.7e-23 80.6 0.1 2.4 2 0 0 2 2 2 2 CAP-Gly domain KASH PF10541.7 T174181_3 - 1.2e-11 44.5 6.1 3.6e-11 43.0 6.1 1.8 1 0 0 1 1 1 1 Nuclear envelope localisation domain Ank_2 PF12796.5 T174181_3 - 6.5e-10 39.3 0.6 1.4e-07 31.9 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) THAP PF05485.10 T174181_3 - 8.7e-07 29.7 1.3 1.3e-06 29.2 0.2 1.9 2 0 0 2 2 2 1 THAP domain Ank_4 PF13637.4 T174181_3 - 1.6e-05 25.2 1.1 0.018 15.5 0.2 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 T174181_3 - 5.4e-05 23.3 6.0 0.23 11.8 0.1 3.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.28 T174181_3 - 6.4e-05 23.1 5.2 1.2 9.6 0.7 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.4 T174181_3 - 0.00093 19.4 2.2 13 6.6 0.3 3.7 3 0 0 3 3 3 2 Ankyrin repeat Lectin_C PF00059.19 T044817_3 - 1.7e-22 80.1 0.0 2.9e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 T044817_3 - 1.5e-09 37.3 34.8 3.4e-05 23.4 15.1 2.4 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) PIEZO PF15917.3 T221157_1 - 1.2 8.4 5.6 2.1 7.6 5.6 1.3 1 0 0 1 1 1 0 Piezo G-alpha PF00503.18 T221157_2 - 3.8e-45 154.4 0.1 5.1e-45 154.0 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_24 PF13479.4 T221157_2 - 0.13 11.9 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain TniB PF05621.9 T221157_2 - 0.15 11.1 0.2 0.23 10.5 0.2 1.1 1 0 0 1 1 1 0 Bacterial TniB protein G-alpha PF00503.18 T221157_3 - 7.1e-53 179.9 0.1 9.2e-53 179.5 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 T221157_3 - 3.5e-10 39.5 0.4 5.8e-10 38.8 0.4 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family IML1 PF12257.6 T232415_3 - 2.2e-114 381.3 0.3 3.5e-114 380.6 0.3 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.19 T232415_3 - 1.8e-10 40.6 0.1 4.2e-10 39.4 0.1 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FGGY_N PF00370.19 T232415_3 - 0.026 13.9 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Kinesin PF00225.21 T045969_3 - 5.8e-94 314.6 7.5 5.8e-94 314.6 7.5 4.0 5 1 0 5 5 5 1 Kinesin motor domain Microtub_bd PF16796.3 T045969_3 - 2.5e-14 53.4 0.1 2.5e-14 53.4 0.1 5.1 5 0 0 5 5 5 2 Microtubule binding TPR_11 PF13414.4 T045969_3 - 0.17 11.5 2.0 1.3 8.6 0.4 2.4 2 0 0 2 2 2 0 TPR repeat Pkinase PF00069.23 T242682_1 - 4.2e-61 206.5 0.1 5.3e-61 206.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T242682_1 - 9.8e-22 77.3 0.0 1.4e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T242682_1 - 0.00065 19.0 0.0 0.019 14.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like zf-RING_2 PF13639.4 T242682_3 - 9.7e-09 35.2 7.9 9.7e-09 35.2 7.9 3.3 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.23 T242682_3 - 3.3e-05 23.5 6.2 9.6e-05 22.0 6.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T242682_3 - 0.00048 20.1 5.0 0.00048 20.1 5.0 2.4 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.3 T242682_3 - 0.001 18.6 7.5 0.0033 17.0 7.5 1.9 1 0 0 1 1 1 1 RING-like zinc finger WEMBL PF05701.9 T242682_3 - 0.021 13.4 27.3 0.45 9.0 15.8 2.1 1 1 1 2 2 2 0 Weak chloroplast movement under blue light Spc7 PF08317.9 T242682_3 - 0.78 8.4 32.3 0.028 13.2 8.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein MscS_porin PF12795.5 T242682_3 - 1.6 8.1 24.8 0.9 8.9 1.9 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Reo_sigmaC PF04582.10 T242682_3 - 1.9 7.6 5.8 2 7.6 1.0 2.0 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF3450 PF11932.6 T242682_3 - 3.5 6.7 24.3 0.76 8.9 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) HIP1_clath_bdg PF16515.3 T242682_3 - 6.5 7.3 34.5 0.4 11.2 9.5 3.3 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HECT PF00632.23 T205256_3 - 6.8e-104 347.5 0.0 1.1e-103 346.8 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HECW_N PF16562.3 T205256_3 - 2.5e-58 195.0 0.0 4e-58 194.3 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 WW PF00397.24 T205256_3 - 2.5e-17 62.4 0.4 1.6e-09 37.4 0.3 2.5 2 0 0 2 2 2 2 WW domain C2 PF00168.28 T205256_3 - 2.8e-11 43.5 0.0 5.7e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain Cep57_CLD PF14073.4 T205256_3 - 0.23 11.3 0.4 0.58 10.0 0.4 1.6 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 MRVI1 PF05781.10 T054744_1 - 5.4e-69 233.2 1.8 7.2e-69 232.8 1.8 1.1 1 0 0 1 1 1 1 MRVI1 protein DUF1725 PF08333.9 T054744_1 - 6.3e-08 31.9 0.7 1.3e-07 30.9 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Yae1_N PF09811.7 T054744_1 - 0.58 9.8 3.3 0.53 9.9 0.3 2.1 2 0 0 2 2 2 0 Essential protein Yae1, N terminal MRVI1 PF05781.10 T054744_3 - 1.9e-126 422.8 0.3 1.9e-126 422.8 0.3 1.5 2 0 0 2 2 2 1 MRVI1 protein Xlink PF00193.15 T054744_3 - 2.6e-18 66.0 0.0 7.2e-18 64.6 0.0 1.8 1 0 0 1 1 1 1 Extracellular link domain fn3 PF00041.19 T246918_1 - 4e-14 52.6 10.9 2.8e-09 37.0 0.6 4.3 4 0 0 4 4 4 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 T246918_1 - 4.8e-06 26.9 0.1 0.13 12.7 0.0 3.1 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 T246918_1 - 0.00078 19.6 0.1 0.25 11.5 0.0 2.6 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III 6PGD PF00393.17 T002902_1 - 1.5e-129 431.4 0.0 1.9e-129 431.1 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.13 T002902_1 - 6.8e-48 162.7 0.0 9.4e-48 162.2 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Kinesin PF00225.21 T002902_2 - 1.7e-115 385.4 0.6 2.3e-115 384.9 0.6 1.2 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.3 T002902_2 - 4.4e-79 264.7 4.1 2.8e-63 213.2 0.4 3.0 1 1 1 2 2 2 2 Kinesin-associated DUF3694 PF12473.6 T002902_2 - 5.3e-38 130.9 0.0 1.1e-37 129.9 0.0 1.6 1 0 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.3 T002902_2 - 3.6e-24 85.3 0.2 1.5e-23 83.2 0.2 2.1 2 0 0 2 2 2 1 Microtubule binding PH PF00169.27 T002902_2 - 5.3e-14 52.5 0.4 4.7e-11 43.0 0.0 3.6 4 0 0 4 4 4 1 PH domain KIF1B PF12423.6 T002902_2 - 2.8e-11 43.6 0.1 2.8e-11 43.6 0.1 2.3 2 0 0 2 2 2 1 Kinesin protein 1B FHA PF00498.24 T002902_2 - 1.7e-07 31.4 0.4 4.3e-07 30.0 0.1 1.9 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.3 T002902_2 - 0.0015 18.7 0.0 0.0034 17.5 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Peptidase_C1 PF00112.21 T061723_1 - 2.4e-45 155.2 0.1 2.4e-45 155.2 0.1 1.4 2 0 0 2 2 2 1 Papain family cysteine protease Peptidase_C1_2 PF03051.13 T061723_1 - 0.0008 18.1 0.0 0.0012 17.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.21 T061723_3 - 3.5e-17 63.1 0.1 5e-17 62.6 0.1 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 T061723_3 - 1.8e-07 31.4 0.6 3.2e-07 30.5 0.6 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) GKAP PF03359.11 T157886_2 - 1.7e-154 514.4 3.6 1.7e-154 514.4 3.6 2.4 2 1 0 2 2 2 1 Guanylate-kinase-associated protein (GKAP) protein SNF PF00209.16 T277626_1 - 2.5e-65 221.0 11.0 1.5e-40 139.3 3.0 2.1 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family SNF PF00209.16 T277626_3 - 4.9e-154 513.8 9.8 6.6e-154 513.3 9.8 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Acyltransferase PF01553.19 T277626_3 - 5.3e-15 55.1 0.0 9.7e-15 54.3 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase EF-hand_8 PF13833.4 T277626_3 - 5.9e-10 38.6 1.0 9.2e-08 31.6 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.4 T277626_3 - 4.2e-06 27.0 0.3 0.0004 20.7 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 T277626_3 - 5.8e-06 25.7 0.1 0.052 13.4 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 T277626_3 - 3.2e-05 23.0 0.4 0.085 12.3 0.0 2.6 2 0 0 2 2 2 2 EF hand RRM_1 PF00076.20 T166799_2 - 5.4e-13 48.4 0.0 9.8e-13 47.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.25 T166799_2 - 2.2e-09 36.7 0.5 4.5e-09 35.7 0.5 1.6 1 0 0 1 1 1 1 SAP domain RRM_5 PF13893.4 T166799_2 - 1.5e-06 27.7 0.0 2.8e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trypsin PF00089.24 T334575_3 - 5.3e-40 137.4 0.0 7.2e-40 137.0 0.0 1.1 1 0 0 1 1 1 1 Trypsin Collagen PF01391.16 T208978_2 - 9.5e-76 249.3 281.5 1.8e-09 37.1 20.4 11.3 4 4 7 11 11 11 11 Collagen triple helix repeat (20 copies) C4 PF01413.17 T208978_2 - 4.5e-41 139.6 0.1 7.1e-41 138.9 0.1 1.3 1 0 0 1 1 1 1 C-terminal tandem repeated domain in type 4 procollagen Collagen PF01391.16 T208978_3 - 5.1e-108 352.7 432.2 5.5e-09 35.5 31.8 16.3 4 3 12 16 16 16 14 Collagen triple helix repeat (20 copies) C4 PF01413.17 T208978_3 - 2.6e-10 40.5 0.0 4.7e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 C-terminal tandem repeated domain in type 4 procollagen Fam20C PF06702.10 T153106_1 - 3.6e-61 206.6 0.2 1.5e-49 168.6 0.1 2.2 2 0 0 2 2 2 2 Golgi casein kinase, C-terminal, Fam20 Fam20C PF06702.10 T153106_2 - 6e-22 78.4 0.0 1e-21 77.7 0.0 1.3 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.4 T153106_2 - 0.0073 15.1 0.0 0.013 14.3 0.0 1.3 1 0 0 1 1 1 1 FAM198 protein Diphthamide_syn PF01866.15 T009604_1 - 1.1e-61 208.8 0.0 1.5e-61 208.3 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein CCDC24 PF15669.3 T009604_1 - 2.7e-21 76.3 0.0 4.5e-21 75.5 0.0 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family Glyco_transf_7N PF13733.4 T009604_2 - 4.5e-54 181.6 0.0 6.8e-54 181.0 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 CCDC24 PF15669.3 T009604_2 - 1.6e-35 122.7 0.6 1.6e-35 122.7 0.6 1.9 3 0 0 3 3 3 1 Coiled-coil domain-containing protein 24 family Glyco_transf_7C PF02709.12 T009604_2 - 1.1e-29 101.7 0.4 1.1e-29 101.7 0.4 1.9 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Xpo1 PF08389.10 T009604_2 - 9.9e-27 93.7 3.5 7.8e-25 87.5 0.1 3.3 3 0 0 3 3 3 2 Exportin 1-like protein IBN_N PF03810.17 T009604_2 - 4.3e-08 32.8 0.4 9.5e-08 31.7 0.4 1.6 1 0 0 1 1 1 1 Importin-beta N-terminal domain Glyco_tranf_2_2 PF10111.7 T009604_2 - 0.24 10.7 0.0 0.38 10.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 ATP-synt_C PF00137.19 T009604_3 - 2e-21 75.9 31.0 7.6e-13 48.5 10.4 4.0 4 0 0 4 4 4 2 ATP synthase subunit C zf-H2C2_2 PF13465.4 T337430_2 - 1.1e-83 272.1 100.2 9.3e-10 38.4 3.3 14.4 13 1 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 T337430_2 - 1.6e-51 169.9 118.7 6.7e-06 26.1 1.4 13.8 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T337430_2 - 5.7e-29 98.2 112.0 0.00072 20.0 1.2 13.6 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 T337430_2 - 6.1e-21 73.7 0.1 1.1e-20 72.9 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 T337430_2 - 2.1e-12 46.9 71.4 0.015 15.5 0.4 12.2 11 1 1 12 12 11 8 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T337430_2 - 2.9e-10 39.7 96.8 0.0052 16.6 0.7 12.6 12 0 0 12 12 12 7 C2H2-type zinc finger GAGA PF09237.9 T337430_2 - 9.8e-05 22.0 22.3 0.6 9.8 0.3 7.8 2 2 5 8 8 8 3 GAGA factor Zn-ribbon_8 PF09723.8 T337430_2 - 0.0014 18.5 53.1 0.018 15.0 0.2 8.5 5 1 2 8 8 8 5 Zinc ribbon domain BHD_1 PF10403.7 T337430_2 - 0.015 15.0 1.4 13 5.6 0.0 4.4 4 0 0 4 4 4 0 Rad4 beta-hairpin domain 1 Ta0938 PF11494.6 T337430_2 - 0.016 15.4 23.3 1.9 8.7 0.3 6.5 2 1 5 7 7 7 0 Ta0938 BolA PF01722.16 T337430_2 - 0.042 14.0 21.5 5.1 7.3 0.3 5.8 3 1 3 6 6 6 0 BolA-like protein FYVE PF01363.19 T337430_2 - 1.6 8.8 69.6 52 4.0 15.1 7.5 1 1 3 4 4 3 0 FYVE zinc finger zinc_ribbon_15 PF17032.3 T337430_2 - 5 7.8 39.1 1.9 9.1 1.3 6.4 3 1 4 7 7 7 0 zinc-ribbon family Ectoine_synth PF06339.10 T337430_3 - 0.066 13.3 0.2 0.34 11.0 0.0 2.2 1 1 0 1 1 1 0 Ectoine synthase BAR PF03114.16 T198497_3 - 7.5e-42 143.5 10.7 1.1e-41 142.9 10.7 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 T198497_3 - 2.8e-10 39.7 0.1 6.4e-10 38.6 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T198497_3 - 1e-06 28.2 0.0 3e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T198497_3 - 1.9e-06 27.2 0.1 4.3e-06 26.1 0.1 1.6 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.3 T198497_3 - 0.00021 20.9 8.6 0.0004 20.0 7.9 1.8 1 1 1 2 2 2 1 BAR domain of APPL family Jnk-SapK_ap_N PF09744.7 T198497_3 - 0.016 15.3 1.7 0.016 15.3 1.7 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 OmpH PF03938.12 T198497_3 - 0.12 12.3 11.7 0.049 13.5 2.0 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3104 PF11302.6 T198497_3 - 0.14 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) IncA PF04156.12 T198497_3 - 2.1 8.0 7.1 8.6 6.0 1.1 2.3 2 0 0 2 2 2 0 IncA protein BLOC1_2 PF10046.7 T198497_3 - 3.3 8.0 11.3 0.53 10.5 1.9 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YkyA PF10368.7 T198497_3 - 4.4 6.9 12.8 0.12 11.9 1.4 2.5 2 1 0 2 2 2 0 Putative cell-wall binding lipoprotein EF-hand_1 PF00036.30 T217201_1 - 5e-15 53.7 7.1 3.2e-07 29.3 1.6 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 T217201_1 - 6.3e-13 48.9 5.0 1.1e-06 28.8 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 T217201_1 - 2.4e-11 42.5 8.1 2e-07 30.2 0.9 3.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 T217201_1 - 2e-06 27.3 6.6 0.0073 15.9 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 T217201_1 - 2.2e-05 23.6 3.1 4.3e-05 22.7 1.5 2.1 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.9 T217201_1 - 0.00059 20.5 0.1 0.0022 18.7 0.0 1.8 1 1 1 2 2 2 1 EF-hand domain GPHH PF16905.3 T217201_1 - 0.0011 18.5 0.0 1.9 8.2 0.0 2.4 2 0 0 2 2 2 2 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_9 PF14658.4 T217201_1 - 0.017 15.3 0.0 6.4 7.0 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain UPF0154 PF03672.11 T217201_1 - 0.023 14.6 0.0 8.7 6.3 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) SPARC_Ca_bdg PF10591.7 T217201_1 - 0.1 12.8 0.3 0.21 11.8 0.3 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region TIM21 PF08294.9 T164047_1 - 1.9e-37 128.2 0.1 2.8e-37 127.7 0.1 1.2 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.8 T164047_1 - 0.0089 15.6 0.0 0.026 14.2 0.0 1.7 2 0 0 2 2 2 1 Cytochrome oxidase complex assembly protein 1 HLH PF00010.24 T147791_1 - 4.3e-15 55.3 0.1 7.3e-15 54.5 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain adh_short PF00106.23 T147791_1 - 3.5e-14 52.6 1.8 3.7e-09 36.2 0.0 3.2 4 0 0 4 4 4 2 short chain dehydrogenase adh_short_C2 PF13561.4 T147791_1 - 3.7e-05 23.3 0.0 0.00043 19.8 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 T147791_2 - 0.0019 17.5 0.0 0.0026 17.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 T147791_2 - 0.049 13.0 0.0 0.071 12.5 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase CoaE PF01121.18 T147791_3 - 9.4e-39 132.8 0.0 1.5e-38 132.2 0.0 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase CTP_transf_like PF01467.24 T147791_3 - 1.1e-07 32.0 0.0 1.7e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like AAA_33 PF13671.4 T147791_3 - 0.00083 19.4 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 T147791_3 - 0.014 15.8 0.0 0.027 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain PRK PF00485.16 T147791_3 - 0.43 10.1 0.8 0.68 9.5 0.8 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Ank_2 PF12796.5 T174135_2 - 1.1e-09 38.6 0.8 7.4e-09 36.0 0.2 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.28 T174135_2 - 2.8e-09 36.9 6.6 0.00096 19.4 0.6 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.4 T174135_2 - 6.1e-07 29.1 3.1 0.1 13.0 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.4 T174135_2 - 1.1e-06 29.0 1.3 0.07 13.6 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 T174135_2 - 8.2e-05 22.7 6.6 0.035 14.4 0.5 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 T174135_3 - 3.4e-08 33.8 0.8 0.00011 22.6 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 T174135_3 - 2.3e-06 27.7 0.9 0.0045 17.2 0.2 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 T174135_3 - 2.1e-05 24.4 0.3 0.06 13.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 T174135_3 - 0.00012 22.5 0.1 0.0097 16.3 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 T174135_3 - 0.00086 19.5 1.3 0.037 14.3 0.2 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) THAP PF05485.10 T064257_3 - 4.4e-17 62.7 3.8 1.3e-16 61.2 3.8 1.9 1 0 0 1 1 1 1 THAP domain DUF4371 PF14291.4 T064257_3 - 2.9e-15 56.5 0.0 6e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.12 T064257_3 - 3.2e-12 45.9 0.0 7.1e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region adh_short PF00106.23 T274218_1 - 1.3e-05 24.6 0.6 1.8e-05 24.2 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 T274218_1 - 0.068 12.6 0.6 0.096 12.1 0.6 1.1 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase adh_short_C2 PF13561.4 T274218_3 - 4.3e-38 131.1 0.0 5.6e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 T274218_3 - 1.8e-30 105.8 0.1 2.4e-30 105.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Zip PF02535.20 T080193_1 - 3e-64 217.2 0.1 4e-64 216.8 0.1 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter tRNA_anti-codon PF01336.23 T080193_1 - 1.6e-05 24.7 0.2 2.9e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain CPSase_L_D2 PF02786.15 T255753_1 - 3.8e-77 258.4 0.3 6.2e-77 257.7 0.3 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.17 T255753_1 - 4e-36 123.2 0.0 1.4e-35 121.5 0.0 1.9 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.20 T255753_1 - 1.3e-25 89.9 0.3 7.8e-24 84.2 0.0 2.4 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.20 T255753_1 - 6e-17 61.1 0.2 1.5e-16 59.8 0.2 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.11 T255753_1 - 2.9e-14 52.9 0.1 6.2e-14 51.9 0.1 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.20 T255753_1 - 2e-11 43.6 0.3 3.4e-11 42.9 0.3 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.4 T255753_1 - 1.4e-08 33.7 0.0 5.4e-08 31.8 0.0 1.7 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.4 T255753_1 - 4.6e-07 29.5 0.0 0.0008 19.1 0.0 2.6 2 0 0 2 2 2 2 Biotin-lipoyl like ATP-grasp_3 PF02655.12 T255753_1 - 9.1e-07 28.9 0.1 1.6e-06 28.2 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.9 T255753_1 - 3.8e-06 26.5 0.0 1.3e-05 24.8 0.0 1.8 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.4 T255753_1 - 0.0018 17.4 1.7 0.1 11.7 0.1 3.0 3 0 0 3 3 3 1 Sugar-transfer associated ATP-grasp ATP-grasp_4 PF13535.4 T255753_1 - 0.0022 17.5 0.1 0.0038 16.7 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.17 T255753_1 - 0.0029 17.3 0.1 0.0053 16.4 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RnfC_N PF13375.4 T255753_1 - 0.0051 16.6 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain HlyD_D23 PF16576.3 T255753_1 - 0.0067 15.5 0.0 0.54 9.3 0.0 2.2 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion PTS_EIIA_1 PF00358.18 T255753_1 - 0.021 14.4 0.8 7.3 6.2 0.1 3.1 2 1 0 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 HlyD_3 PF13437.4 T255753_1 - 0.025 15.2 0.0 9.1 6.9 0.0 2.7 2 0 0 2 2 2 0 HlyD family secretion protein NQRA PF05896.9 T255753_1 - 0.11 11.8 0.1 0.19 11.0 0.1 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) PI-PLC-X PF00388.17 T370424_3 - 8.7e-05 22.0 0.0 0.00017 21.1 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain DNA_ligase_A_M PF01068.19 T098777_3 - 9.2e-57 191.8 0.2 1.7e-56 191.0 0.2 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 T098777_3 - 1.5e-41 142.5 0.4 2.4e-41 141.8 0.4 1.4 1 0 0 1 1 1 1 DNA ligase N terminus BRCT PF00533.24 T098777_3 - 9.7e-18 64.2 0.1 1.1e-09 38.5 0.0 2.8 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain DNA_ligase_IV PF11411.6 T098777_3 - 1.2e-16 60.4 1.1 1.2e-16 60.4 1.1 2.0 2 0 0 2 2 2 1 DNA ligase IV DNA_ligase_A_C PF04679.13 T098777_3 - 1.5e-15 57.4 0.0 3.4e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.3 T098777_3 - 1.2e-13 51.2 0.1 6e-09 36.1 0.0 2.6 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.8 T098777_3 - 7.4e-09 36.0 0.1 1.2e-08 35.3 0.1 1.3 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.17 T098777_3 - 0.028 14.1 0.8 0.24 11.1 0.8 2.1 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain APG17 PF04108.10 T098777_3 - 0.03 13.3 0.8 0.084 11.8 0.4 1.9 2 0 0 2 2 2 0 Autophagy protein Apg17 IQ_SEC7_PH PF16453.3 T375019_2 - 1.6e-63 212.7 0.3 3.2e-63 211.7 0.3 1.5 1 0 0 1 1 1 1 PH domain Sec7 PF01369.18 T375019_2 - 2.1e-55 187.1 0.0 3.3e-55 186.5 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain SlyX PF04102.10 T375019_2 - 0.82 10.2 5.6 2.3 8.8 5.6 1.8 1 0 0 1 1 1 0 SlyX Spectrin PF00435.19 T313759_3 - 1.6e-137 449.4 801.0 2.1e-10 40.9 8.5 74.7 68 9 7 75 75 75 47 Spectrin repeat CH PF00307.29 T313759_3 - 5.6e-44 148.7 2.0 2.8e-20 72.4 0.0 5.3 4 0 0 4 4 4 2 Calponin homology (CH) domain KASH PF10541.7 T313759_3 - 1.1e-26 92.7 6.0 2.2e-26 91.7 6.0 1.6 1 0 0 1 1 1 1 Nuclear envelope localisation domain CAMSAP_CH PF11971.6 T313759_3 - 1.5e-06 27.8 0.0 0.031 14.0 0.0 3.4 2 0 0 2 2 2 2 CAMSAP CH domain Coatomer_g_Cpla PF16381.3 T313759_3 - 0.14 12.1 2.2 4.1 7.4 0.1 4.7 3 0 0 3 3 3 0 Coatomer subunit gamma-1 C-terminal appendage platform MukB PF04310.10 T313759_3 - 2.8 7.5 10.4 3 7.5 0.2 5.2 4 0 0 4 4 4 0 MukB N-terminal MIB_HERC2 PF06701.11 T000907_2 - 4.1e-45 151.8 27.9 9.1e-23 80.2 6.8 3.2 3 0 0 3 3 3 2 Mib_herc2 Ank_2 PF12796.5 T000907_2 - 1.8e-38 130.9 7.0 7.8e-11 42.3 0.6 5.5 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T000907_2 - 1.4e-36 123.8 16.0 2.6e-08 33.9 0.1 7.3 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.4 T000907_2 - 8.3e-34 115.4 3.8 2.3e-09 37.5 0.0 6.5 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 T000907_2 - 4.2e-26 90.1 12.3 1.2e-05 25.3 0.0 9.7 9 0 0 9 9 9 5 Ankyrin repeat Ank_3 PF13606.4 T000907_2 - 5.9e-25 84.5 6.4 0.00083 19.5 0.1 8.7 9 0 0 9 9 8 5 Ankyrin repeat zf-C3HC4_3 PF13920.4 T000907_2 - 1.1e-09 37.8 26.0 1.2e-06 28.2 8.4 4.1 4 0 0 4 4 2 2 Zinc finger, C3HC4 type (RING finger) Peptidase_M10 PF00413.22 T000907_2 - 2.2e-09 37.2 0.3 4.3e-09 36.3 0.3 1.4 1 0 0 1 1 1 1 Matrixin ZZ PF00569.15 T000907_2 - 2e-07 30.6 10.4 2e-07 30.6 10.4 2.6 2 0 0 2 2 2 1 Zinc finger, ZZ type ShK PF01549.22 T000907_2 - 2.9e-06 27.6 5.0 1.1e-05 25.7 5.0 2.1 1 0 0 1 1 1 1 ShK domain-like Ig_2 PF13895.4 T000907_2 - 4.3e-05 23.7 0.1 9.7e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Reprolysin_4 PF13583.4 T000907_2 - 0.017 14.6 3.1 0.029 13.9 3.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF2710 PF10921.6 T000907_2 - 0.057 13.7 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2710) Reprolysin_3 PF13582.4 T000907_2 - 0.07 13.5 0.6 0.14 12.5 0.6 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 T000907_2 - 0.074 12.1 2.4 0.12 11.5 2.4 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M57 PF12388.6 T000907_2 - 0.25 10.8 1.0 0.57 9.6 1.0 1.5 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Astacin PF01400.22 T000907_2 - 0.33 10.4 1.8 0.7 9.3 1.8 1.4 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.4 T000907_2 - 1.2 9.1 2.8 2.3 8.2 2.8 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M10 PF00413.22 T000907_3 - 1.6e-19 70.1 0.0 2.4e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 Matrixin 7tm_4 PF13853.4 T058699_3 - 2.6e-41 142.0 25.1 3.7e-41 141.6 25.1 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T058699_3 - 2.4e-19 69.5 23.5 5e-19 68.4 23.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Metallophos PF00149.26 T086388_2 - 2.3e-39 135.9 0.1 3.3e-39 135.4 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 T086388_2 - 5.3e-23 81.1 1.8 4.2e-22 78.2 2.3 2.2 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Kinesin PF00225.21 T214148_1 - 9.2e-113 376.4 0.2 9.2e-113 376.4 0.2 3.5 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.3 T214148_1 - 1e-24 87.0 0.1 1e-24 87.0 0.1 2.5 3 0 0 3 3 3 1 Microtubule binding Kinesin_assoc PF16183.3 T214148_1 - 1.6e-07 31.5 3.8 0.00014 21.9 0.3 6.5 3 3 2 6 6 6 2 Kinesin-associated FHA PF00498.24 T214148_1 - 3.6e-05 23.9 0.2 0.00018 21.6 0.1 2.4 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.3 T214148_1 - 5.6e-05 23.2 3.1 5.7e-05 23.2 0.0 2.7 3 0 0 3 3 3 1 Inner membrane component of T3SS, cytoplasmic domain HlyIII PF03006.18 T251655_3 - 2.9e-31 108.8 16.8 5.3e-31 107.9 16.8 1.4 1 0 0 1 1 1 1 Haemolysin-III related Transposase_22 PF02994.12 T251655_3 - 0.014 14.2 0.3 0.02 13.6 0.3 1.1 1 0 0 1 1 1 0 L1 transposable element Tetraspannin PF00335.18 T052493_1 - 6.8e-48 163.1 12.0 9.9e-48 162.6 12.0 1.2 1 0 0 1 1 1 1 Tetraspanin family Patatin PF01734.20 T052493_1 - 2.8e-14 53.6 0.1 5.7e-14 52.6 0.1 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase CD20 PF04103.13 T052493_1 - 2.6e-05 24.2 0.3 5.3e-05 23.2 0.3 1.5 1 0 0 1 1 1 1 CD20-like family EF-hand_7 PF13499.4 T052493_1 - 4.3e-05 23.8 0.1 7.7e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T052493_1 - 0.00016 21.2 0.0 0.5 10.3 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain DUF4199 PF13858.4 T052493_1 - 0.0015 18.9 0.8 0.0026 18.1 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) SUR7 PF06687.10 T052493_1 - 0.011 15.3 1.8 0.02 14.4 1.8 1.3 1 0 0 1 1 1 0 SUR7/PalI family DUF2569 PF10754.7 T052493_1 - 2 8.7 5.3 3.3 8.0 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) DUF3040 PF11239.6 T052493_1 - 5.4 7.2 5.2 21 5.4 5.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Ribosomal_60s PF00428.17 T052493_3 - 1.2e-23 83.3 7.6 1.2e-23 83.3 7.6 3.1 4 0 0 4 4 4 1 60s Acidic ribosomal protein IncA PF04156.12 T052493_3 - 9.2 5.9 13.0 16 5.1 13.0 1.3 1 0 0 1 1 1 0 IncA protein ASCH PF04266.12 T381423_2 - 0.0097 16.4 0.0 0.014 15.9 0.0 1.2 1 0 0 1 1 1 1 ASCH domain TSNAXIP1_N PF15739.3 T189642_3 - 7.6e-23 80.9 1.3 1.3e-16 60.9 0.5 2.8 2 0 0 2 2 2 2 Translin-associated factor X-interacting N-terminus Clathrin_H_link PF13838.4 T189642_3 - 2.2e-10 40.1 0.0 4.7e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Clathrin-H-link Ig_3 PF13927.4 T226370_1 - 3.9e-09 36.9 1.6 0.00021 21.7 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 T226370_1 - 8e-09 35.6 0.4 0.0027 17.9 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 T226370_1 - 3.8e-08 33.2 0.0 8.3e-06 25.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 T226370_1 - 9e-08 32.1 0.1 0.0011 18.9 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 T226370_1 - 0.003 17.6 0.2 0.98 9.5 0.0 3.1 2 1 0 2 2 2 2 Immunoglobulin V-set domain DUF4179 PF13786.4 T226370_2 - 0.37 11.1 1.3 0.7 10.3 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) Aldo_ket_red PF00248.19 T141187_2 - 2.6e-46 158.0 0.0 3.4e-46 157.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Sybindin PF04099.10 T141187_3 - 4.1e-43 146.6 0.0 5.6e-43 146.2 0.0 1.2 1 0 0 1 1 1 1 Sybindin-like family Aldo_ket_red PF00248.19 T141187_3 - 8.2e-13 48.0 0.0 1.2e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.23 T218200_1 - 1.3e-67 227.8 0.0 1.7e-67 227.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T218200_1 - 7.6e-33 113.8 0.0 1e-32 113.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T218200_1 - 0.00012 21.4 0.0 0.00019 20.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 T218200_1 - 0.00055 20.4 0.1 0.0012 19.4 0.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.12 T218200_1 - 0.014 14.7 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3715 PF12509.6 T036509_2 - 2.2e-87 290.5 14.4 4.2e-39 133.8 2.3 3.9 3 0 0 3 3 3 3 Protein of unknown function (DUF3715) DUF3699 PF12480.6 T036509_2 - 1.3e-28 98.8 0.2 4.4e-24 84.3 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF3699) DUF3884 PF13024.4 T036509_2 - 0.041 13.3 0.4 0.3 10.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3884) Solute_trans_a PF03619.14 T317301_1 - 5e-87 291.7 9.9 8e-49 166.4 4.7 2.1 2 0 0 2 2 2 2 Organic solute transporter Ostalpha PAC3 PF10178.7 T317301_3 - 1.1e-25 89.4 0.1 1.8e-25 88.7 0.1 1.3 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 PHD PF00628.27 T222103_1 - 3.1e-10 39.7 8.0 3.1e-10 39.7 8.0 3.2 3 0 0 3 3 3 1 PHD-finger TFIIS_M PF07500.12 T222103_2 - 6.5e-26 90.8 1.8 1e-25 90.2 1.8 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.11 T222103_2 - 3.5e-24 85.3 0.0 6.1e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 SPOC domain CARD PF00619.19 T134309_1 - 4.9e-17 61.6 0.0 7.7e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 Caspase recruitment domain F-box-like PF12937.5 T134309_1 - 1.6e-09 37.4 1.1 3.4e-09 36.3 0.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 T134309_1 - 8.8e-07 28.5 0.0 4.6e-06 26.2 0.0 2.2 2 0 0 2 2 2 1 F-box domain HSF_DNA-bind PF00447.15 T134309_2 - 3.3e-30 104.4 0.0 5.1e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding Rad9 PF04139.11 T086353_3 - 9.9e-70 234.7 2.3 3.8e-68 229.5 2.3 2.2 1 1 0 1 1 1 1 Rad9 HMG_box PF00505.17 T055365_2 - 1.2e-21 76.7 4.5 2.5e-21 75.7 4.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T055365_2 - 8.7e-09 35.7 1.1 8.7e-09 35.7 1.1 2.3 2 0 0 2 2 2 1 HMG-box domain MPS2 PF17060.3 T055365_2 - 0.24 10.5 10.7 0.41 9.7 10.7 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 ASC PF00858.22 T335893_1 - 1.5e-91 307.2 0.0 1.9e-91 307.0 0.0 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel ABC_membrane PF00664.21 T335893_2 - 5e-52 177.1 3.8 6.7e-52 176.7 3.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 T335893_2 - 3.8e-31 108.3 0.0 5.8e-31 107.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 T335893_2 - 7.5e-05 22.1 0.0 0.00017 21.0 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.10 T335893_2 - 0.00018 20.7 0.0 0.00034 19.8 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.4 T335893_2 - 0.00036 20.8 0.0 0.00073 19.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 T335893_2 - 0.0066 16.6 0.2 0.053 13.7 0.2 2.1 1 1 0 1 1 1 1 AAA domain ABC_membrane_2 PF06472.13 T335893_2 - 0.025 13.8 2.2 0.038 13.2 2.2 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 AAA_30 PF13604.4 T335893_2 - 0.052 13.1 0.7 0.16 11.5 0.7 1.7 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.15 T335893_2 - 0.083 12.8 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF87 APS_kinase PF01583.18 T335893_2 - 0.097 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_25 PF13481.4 T335893_2 - 0.17 11.3 0.4 1.3 8.5 0.1 2.1 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.4 T335893_2 - 0.21 11.7 0.3 0.99 9.6 0.3 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ABC_ATPase PF09818.7 T335893_2 - 0.27 9.9 0.4 0.53 8.9 0.0 1.5 2 0 0 2 2 2 0 Predicted ATPase of the ABC class FYVE_2 PF02318.14 T139163_2 - 1.3e-36 125.3 2.2 3.4e-36 123.9 2.2 1.8 1 0 0 1 1 1 1 FYVE-type zinc finger zf-piccolo PF05715.11 T139163_2 - 0.0008 19.4 7.3 0.0008 19.4 7.3 2.7 3 0 0 3 3 3 1 Piccolo Zn-finger Oxysterol_BP PF01237.16 T221689_3 - 3.9e-138 460.2 1.9 1.2e-83 280.9 0.2 2.1 2 0 0 2 2 2 2 Oxysterol-binding protein Flavi_NS5 PF00972.18 T221689_3 - 0.23 9.6 0.1 0.33 9.1 0.1 1.1 1 0 0 1 1 1 0 Flavivirus RNA-directed RNA polymerase ORC3_N PF07034.9 T307736_3 - 1e-131 438.9 7.5 1.6e-131 438.2 7.5 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus TPR_12 PF13424.4 T280854_1 - 0.00024 21.2 11.9 0.0011 19.0 1.2 4.0 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.4 T280854_1 - 0.12 12.8 0.1 0.37 11.2 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.26 T280854_1 - 0.69 9.7 6.0 54 3.7 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.15 T280854_1 - 9.8 6.4 10.0 51 4.2 0.3 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat AA_permease PF00324.19 T277441_3 - 7.6e-58 196.1 33.3 5.7e-37 127.3 6.2 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 T277441_3 - 1.3e-46 159.3 4.1 1.7e-29 102.9 2.1 3.0 1 1 1 2 2 2 2 Solute carrier family 12 SH2 PF00017.22 T268681_2 - 4e-18 65.1 0.3 7.1e-18 64.3 0.3 1.4 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 T268681_2 - 4.8e-16 59.0 0.5 8.8e-16 58.2 0.5 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 T268681_2 - 0.0043 17.3 0.1 0.011 16.0 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Neil1-DNA_bind PF09292.8 T119804_1 - 4.4e-17 61.6 0.2 8.9e-17 60.6 0.2 1.5 1 0 0 1 1 1 1 Endonuclease VIII-like 1, DNA bind Fapy_DNA_glyco PF01149.22 T119804_1 - 1.1e-16 61.4 0.0 2.2e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.12 T119804_1 - 1.5e-08 34.4 0.0 2.6e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Amidohydro_1 PF01979.18 T349184_1 - 1.4e-16 60.6 0.0 1.9e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 T349184_1 - 8.7e-08 31.9 0.0 1e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Mucin15 PF15672.3 T056263_2 - 1.4e-165 550.2 13.5 1.8e-165 549.9 13.5 1.1 1 0 0 1 1 1 1 Cell-membrane associated Mucin15 adh_short PF00106.23 T375061_1 - 1.2e-46 158.6 0.9 1.5e-46 158.2 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 T375061_1 - 5.5e-40 137.3 0.0 7.3e-40 136.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 T375061_1 - 1.6e-11 44.3 1.5 2.8e-11 43.5 1.5 1.3 1 0 0 1 1 1 1 KR domain Myb_DNA-bind_7 PF15963.3 T125048_2 - 0.033 13.9 0.1 0.064 13.0 0.1 1.4 1 0 0 1 1 1 0 Myb DNA-binding like Myb_DNA-binding PF00249.29 T125048_2 - 0.12 12.4 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Jnk-SapK_ap_N PF09744.7 T125048_3 - 5.5e-56 189.0 23.9 5.5e-56 189.0 23.9 2.6 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 JIP_LZII PF16471.3 T125048_3 - 4.4e-28 97.1 9.3 4.4e-28 97.1 9.3 2.8 3 1 0 3 3 3 1 JNK-interacting protein leucine zipper II JUPITER PF17054.3 T125048_3 - 1.5e-08 34.4 1.5 9.4e-06 25.2 0.1 2.6 3 0 0 3 3 3 2 Microtubule-Associated protein Jupiter Rootletin PF15035.4 T125048_3 - 0.0013 18.7 1.7 0.0013 18.7 1.7 2.8 2 1 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion Atg14 PF10186.7 T125048_3 - 0.091 11.7 25.8 0.089 11.7 10.5 2.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ERM PF00769.17 T125048_3 - 1.4 8.6 28.5 2.4 7.8 8.3 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family G_glu_transpept PF01019.19 T229954_2 - 3.9e-49 167.7 0.1 4.9e-49 167.3 0.1 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.19 T229954_3 - 1.6e-11 43.6 0.0 2.2e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase TMEM141 PF15110.4 T369556_1 - 9.5e-40 135.0 0.1 1.9e-39 134.0 0.1 1.5 1 0 0 1 1 1 1 TMEM141 protein family Ocnus PF05005.13 T369556_1 - 6.2e-39 132.3 0.2 9.9e-39 131.6 0.2 1.3 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) MAM PF00629.21 T369556_1 - 5.6e-29 100.9 0.0 1.5e-20 73.5 0.0 2.5 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.16 T369556_1 - 6.7e-07 29.3 7.5 1.8e-06 27.9 7.5 1.8 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF2102 PF09875.7 T369556_1 - 0.24 11.0 1.5 0.7 9.5 0.3 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2102) MAM PF00629.21 T369556_3 - 3.5e-16 59.4 0.0 8e-07 28.9 0.0 2.3 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu Ras PF00071.20 T369556_3 - 2.5e-09 36.8 0.0 0.00054 19.5 0.1 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.11 T369556_3 - 5.3e-06 26.5 0.4 4.9e-05 23.4 0.2 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T369556_3 - 0.0045 16.3 0.0 0.0077 15.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family eIF3_subunit PF08597.8 T369556_3 - 0.22 11.3 17.9 0.37 10.5 17.9 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Ldl_recept_a PF00057.16 T369556_3 - 0.42 10.7 8.6 1 9.5 8.6 1.7 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A RNA_polI_A34 PF08208.9 T369556_3 - 1.4 8.9 24.2 3.4 7.6 24.2 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.10 T369556_3 - 2.3 7.8 9.7 3.7 7.2 9.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.12 T369556_3 - 4.2 5.4 11.7 5.9 4.9 11.7 1.1 1 0 0 1 1 1 0 CDC45-like protein MFS_1 PF07690.14 T299053_2 - 2.6e-33 115.3 25.1 1e-26 93.6 14.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.17 T299053_2 - 0.12 10.9 9.1 0.21 10.2 9.1 1.3 1 0 0 1 1 1 0 LacY proton/sugar symporter MFS_1 PF07690.14 T299053_3 - 7e-47 159.9 32.2 2.9e-45 154.6 24.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily FAM131 PF15010.4 T256063_1 - 2.8e-142 473.8 1.7 3.7e-142 473.4 1.7 1.1 1 0 0 1 1 1 1 Putative cell signalling MIF4G PF02854.17 T256063_3 - 1.5e-68 230.5 9.6 2.2e-68 229.9 9.6 1.3 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.15 T256063_3 - 1.5e-29 102.1 0.3 5.7e-29 100.3 0.1 2.1 2 0 0 2 2 2 1 MA3 domain W2 PF02020.16 T256063_3 - 6.3e-18 64.6 0.9 6.3e-18 64.6 0.9 2.1 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Cep57_MT_bd PF06657.11 T256063_3 - 0.4 11.0 3.0 1.5 9.2 3.0 1.9 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DUF1725 PF08333.9 T111184_1 - 0.061 12.9 0.9 0.11 12.1 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Ank_2 PF12796.5 T111184_3 - 4.6e-16 59.0 0.0 8.7e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T111184_3 - 6.9e-15 55.1 0.7 3e-10 40.3 0.5 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_1 PF00018.26 T111184_3 - 2.1e-12 46.3 0.7 2.1e-12 46.3 0.7 1.8 2 0 0 2 2 2 1 SH3 domain Ank_3 PF13606.4 T111184_3 - 2.1e-11 42.8 0.4 8.1e-05 22.6 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.28 T111184_3 - 2.2e-11 43.6 1.0 5.1e-05 23.4 0.2 2.7 2 0 0 2 2 2 2 Ankyrin repeat SH3_9 PF14604.4 T111184_3 - 6.9e-10 38.5 1.8 8.6e-10 38.2 0.2 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 T111184_3 - 4.1e-08 32.7 0.0 9.4e-08 31.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_5 PF13857.4 T111184_3 - 5.1e-08 32.9 0.2 7.7e-07 29.2 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ATG16 PF08614.9 T063533_3 - 3.5e-40 138.2 18.6 5.2e-40 137.7 18.6 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) WD40 PF00400.30 T063533_3 - 2.3e-22 78.7 12.4 5e-05 23.9 0.0 8.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T063533_3 - 0.017 15.3 0.1 19 5.5 0.0 3.8 1 1 4 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain Atg14 PF10186.7 T063533_3 - 2.4 7.0 12.3 4.8 6.0 12.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PMP22_Claudin PF00822.18 T330088_1 - 2.3e-05 24.2 0.3 4e-05 23.4 0.3 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Fis1_TPR_C PF14853.4 T330088_2 - 7.7e-23 80.2 1.6 1.4e-22 79.4 1.6 1.4 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.4 T330088_2 - 4.4e-14 51.7 0.1 1.3e-13 50.2 0.0 1.9 2 0 0 2 2 2 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.15 T330088_2 - 0.21 11.6 0.3 0.46 10.6 0.3 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat PMP22_Claudin PF00822.18 T330088_3 - 9.3e-20 71.0 2.4 1.7e-19 70.2 2.4 1.4 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 T330088_3 - 0.00011 21.8 4.2 0.0002 21.1 4.2 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Interfer-bind PF09294.8 T225299_3 - 9.9e-41 138.1 0.2 3.6e-22 78.5 0.0 2.8 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.15 T225299_3 - 5.7e-27 93.5 7.6 3.8e-15 55.5 0.1 2.8 3 0 0 3 3 3 2 Tissue factor fn3 PF00041.19 T225299_3 - 0.0062 16.7 2.2 0.28 11.4 0.0 3.2 4 0 0 4 4 4 1 Fibronectin type III domain AMP-binding PF00501.26 T228407_1 - 2.7e-93 312.7 0.2 2.4e-65 220.7 0.1 2.3 2 0 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.9 T228407_1 - 4.2e-35 120.8 1.0 7.1e-35 120.1 1.0 1.4 1 0 0 1 1 1 1 DMAP1-binding Domain Transposase_22 PF02994.12 T228407_1 - 1.5e-06 27.2 0.3 2.4e-06 26.5 0.3 1.1 1 0 0 1 1 1 1 L1 transposable element GvpG PF05120.10 T228407_1 - 0.0073 16.2 0.1 0.014 15.3 0.1 1.3 1 0 0 1 1 1 1 Gas vesicle protein G Mtc PF03820.15 T047894_1 - 2.3e-132 440.7 1.1 3e-132 440.3 1.1 1.2 1 0 0 1 1 1 1 Tricarboxylate carrier WBP-1 PF11669.6 T047894_1 - 1.4e-44 150.9 12.2 3.9e-44 149.4 12.2 1.9 1 0 0 1 1 1 1 WW domain-binding protein 1 ABC_membrane_2 PF06472.13 T107263_1 - 1.6e-82 276.9 3.4 2.3e-82 276.4 3.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.25 T107263_1 - 0.00028 21.3 0.0 0.0005 20.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SbmA_BacA PF05992.10 T107263_1 - 0.018 14.3 0.1 0.028 13.7 0.1 1.2 1 0 0 1 1 1 0 SbmA/BacA-like family IRK PF01007.18 T107263_1 - 0.084 11.7 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Inward rectifier potassium channel ABC_tran PF00005.25 T107263_3 - 9.2e-07 29.3 0.4 1.4e-06 28.7 0.4 1.2 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.4 T107263_3 - 0.024 14.9 0.3 0.043 14.1 0.3 1.3 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.18 T107263_3 - 0.056 12.4 0.2 0.083 11.8 0.2 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.4 T107263_3 - 0.069 12.7 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.4 T107263_3 - 0.16 12.1 0.6 0.3 11.2 0.6 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 T107263_3 - 0.18 11.4 1.0 0.35 10.5 1.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.4 T107263_3 - 0.21 11.9 0.6 0.32 11.4 0.6 1.1 1 0 0 1 1 1 0 AAA domain Glyco_hydro_2_C PF02836.15 T325553_2 - 2.7e-114 381.2 0.3 3.4e-114 380.9 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.16 T325553_2 - 5.1e-17 62.2 0.1 8.9e-17 61.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.19 T325553_2 - 4.5e-06 27.2 0.0 7.6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 LIM PF00412.20 T196457_1 - 4.3e-60 199.7 59.7 9.5e-14 51.2 3.0 5.4 5 0 0 5 5 5 5 LIM domain SH3_2 PF07653.15 T154492_1 - 6.4e-10 38.5 0.0 1.4e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T154492_1 - 1.4e-07 31.1 0.0 1.9e-06 27.5 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain Myosin_head PF00063.19 T154492_2 - 1.5e-49 168.7 0.0 2.1e-49 168.3 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.15 T154492_2 - 1.9e-46 156.8 7.6 1.1e-25 90.1 0.0 3.4 4 0 0 4 4 4 2 MyTH4 domain FERM_M PF00373.16 T154492_2 - 3.2e-15 56.4 0.8 7.9e-15 55.2 0.2 2.0 2 0 0 2 2 2 1 FERM central domain IQ PF00612.25 T154492_2 - 0.67 9.8 3.7 2.8 7.8 3.7 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif Myosin_head PF00063.19 T154492_3 - 3e-92 309.9 0.0 4.1e-92 309.4 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.4 T154492_3 - 0.014 15.6 0.0 0.03 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 T154492_3 - 0.022 14.9 0.0 0.037 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain IncA PF04156.12 T232379_1 - 1.4 8.5 11.3 0.043 13.5 2.3 3.0 2 0 0 2 2 2 0 IncA protein FB_lectin PF07367.9 T232379_2 - 0.17 11.7 0.3 0.35 10.7 0.0 1.6 2 0 0 2 2 2 0 Fungal fruit body lectin DUF4392 PF14336.4 T108934_1 - 3.4e-104 348.2 0.0 4.6e-104 347.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF1445 PF07286.10 T108934_1 - 8.1e-37 126.2 0.0 2.6e-36 124.6 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1445) DUF4392 PF14336.4 T108934_2 - 3.5e-10 39.6 0.0 5e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) Pro_dh PF01619.16 T174086_1 - 2.5e-09 36.9 0.1 3.4e-09 36.5 0.1 1.1 1 0 0 1 1 1 1 Proline dehydrogenase DUF1358 PF07096.9 T174086_1 - 1.1 9.2 3.7 1.8 8.5 3.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1358) Pro_dh PF01619.16 T174086_3 - 2.5e-36 125.6 0.2 4.2e-36 124.9 0.0 1.4 2 0 0 2 2 2 1 Proline dehydrogenase LST1 PF05083.11 T301003_1 - 6.2e-40 135.2 0.2 9.5e-40 134.6 0.2 1.3 1 0 0 1 1 1 1 LST-1 protein VanW PF04294.11 T301003_3 - 0.0069 15.9 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 VanW like protein Per1 PF04080.11 T146815_2 - 1.1e-82 277.5 20.4 2.3e-48 165.0 6.9 2.1 2 0 0 2 2 2 2 Per1-like zf-CCCH PF00642.22 T173907_2 - 2.7e-05 23.8 6.4 2.7e-05 23.8 6.4 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.20 T173907_2 - 0.00064 19.4 0.0 0.001 18.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.3 T173907_2 - 0.084 13.4 0.1 0.14 12.7 0.1 1.4 1 0 0 1 1 1 0 Torus domain zf-CCCH PF00642.22 T173907_3 - 0.012 15.4 0.5 0.036 13.8 0.5 1.9 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Toxin_18 PF08087.9 T058966_1 - 0.0077 16.1 0.3 0.0077 16.1 0.3 2.4 2 0 0 2 2 2 1 Conotoxin O-superfamily Yippee-Mis18 PF03226.12 T058966_2 - 1.8e-11 44.0 0.3 3.9e-11 43.0 0.3 1.6 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF836 PF05768.12 T288464_1 - 0.0054 17.0 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) RINGv PF12906.5 T288464_3 - 1.2e-13 50.9 9.8 3.2e-13 49.4 9.8 1.9 1 0 0 1 1 1 1 RING-variant domain DUF836 PF05768.12 T288464_3 - 0.044 14.1 0.0 0.092 13.0 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Arm PF00514.21 T328992_2 - 3.3e-45 150.7 18.4 1.7e-11 43.6 0.2 6.3 6 0 0 6 6 6 6 Armadillo/beta-catenin-like repeat Arm_3 PF16186.3 T328992_2 - 9.6e-20 69.8 1.4 2.5e-19 68.4 1.4 1.7 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.4 T328992_2 - 2.9e-17 62.6 3.0 5.6e-06 26.6 0.0 4.4 3 1 1 4 4 4 3 HEAT-like repeat HEAT_2 PF13646.4 T328992_2 - 1.6e-10 41.1 0.4 0.00031 20.9 0.0 4.3 1 1 4 5 5 5 4 HEAT repeats HEAT PF02985.20 T328992_2 - 3.2e-07 29.9 2.6 0.034 14.2 0.0 4.8 5 0 0 5 5 5 2 HEAT repeat Adaptin_N PF01602.18 T328992_2 - 5.4e-05 21.8 2.5 0.055 11.9 0.8 2.1 1 1 1 2 2 2 2 Adaptin N terminal region V-ATPase_H_C PF11698.6 T328992_2 - 0.00011 22.2 0.6 1.4 8.9 0.0 3.1 2 1 1 3 3 3 3 V-ATPase subunit H Cnd1 PF12717.5 T328992_2 - 0.00011 22.1 1.2 0.23 11.3 0.4 3.3 1 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Arm_2 PF04826.11 T328992_2 - 0.00096 18.6 0.5 0.47 9.7 0.0 2.9 1 1 0 2 2 2 2 Armadillo-like V-ATPase_H_N PF03224.12 T328992_2 - 0.01 15.0 0.9 2 7.5 0.0 2.9 1 1 1 3 3 3 0 V-ATPase subunit H Sec7_N PF12783.5 T328992_2 - 0.011 15.5 0.6 3.1 7.6 0.3 2.6 1 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT_PBS PF03130.14 T328992_2 - 0.071 13.7 0.7 26 5.8 0.0 3.7 3 1 0 3 3 3 0 PBS lyase HEAT-like repeat DUF3385 PF11865.6 T328992_2 - 0.13 12.0 0.7 9 6.0 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3385) DUF3361 PF11841.6 T328992_2 - 0.32 10.8 3.2 49 3.7 0.1 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF3361) Arm PF00514.21 T328992_3 - 0.048 13.6 0.0 0.084 12.8 0.0 1.4 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat LRR_4 PF12799.5 T254395_3 - 3.3e-12 46.2 26.3 0.036 14.3 1.7 6.9 4 1 3 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T254395_3 - 4.9e-05 22.9 24.8 0.17 11.6 0.9 7.3 3 1 4 7 7 7 5 Leucine rich repeat LRR_6 PF13516.4 T254395_3 - 0.00032 20.4 26.4 0.14 12.1 0.0 9.4 10 0 0 10 10 10 2 Leucine Rich repeat LRR_1 PF00560.31 T254395_3 - 0.0016 18.5 25.0 32 5.4 0.1 10.9 11 1 0 11 11 11 1 Leucine Rich Repeat Zfx_Zfy_act PF04704.11 T382853_2 - 1.1e-114 382.9 31.0 4.7e-98 328.2 25.5 2.3 1 1 1 2 2 2 2 Zfx / Zfy transcription activation region zf-C2H2 PF00096.24 T382853_2 - 2.1e-33 112.7 121.0 2.9e-05 24.1 2.1 14.5 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T382853_2 - 1.7e-31 107.1 126.6 4.3e-08 33.1 1.0 14.1 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2_4 PF13894.4 T382853_2 - 7.3e-24 82.3 111.8 0.00037 20.9 0.9 14.2 13 0 0 13 13 13 11 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T382853_2 - 1.4e-22 78.9 95.9 1.2e-06 28.1 5.4 11.6 11 0 0 11 11 11 9 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.3 T382853_2 - 7.6e-05 23.2 48.0 0.088 13.4 2.4 7.5 5 1 2 7 7 7 4 zinc-ribbon family zf-C2H2_6 PF13912.4 T382853_2 - 0.0058 16.4 2.5 0.0058 16.4 2.5 9.3 9 0 0 9 9 9 4 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T382853_2 - 0.0085 15.7 59.6 0.055 13.1 0.3 9.1 9 0 0 9 9 9 6 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 T382853_2 - 0.025 14.7 90.6 0.13 12.5 1.3 12.7 15 0 0 15 15 15 0 Zinc-finger double-stranded RNA-binding Ank_2 PF12796.5 T334756_2 - 3.4e-17 62.7 0.2 1.5e-09 38.2 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T334756_2 - 9.4e-14 50.1 5.1 0.005 17.1 0.0 5.7 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.28 T334756_2 - 1e-13 50.9 1.4 0.0014 18.8 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.4 T334756_2 - 1.9e-11 43.9 5.4 0.00036 20.7 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 T334756_2 - 5e-11 42.8 3.4 0.00017 21.9 0.0 4.8 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ion_trans PF00520.29 T334756_2 - 8.2e-06 25.1 12.6 1.3e-05 24.4 12.6 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans PF00520.29 T334756_3 - 2.8e-09 36.4 0.0 3.8e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Ion transport protein Abhydrolase_1 PF00561.18 T045797_1 - 1.2e-27 97.0 0.8 1.7e-27 96.5 0.8 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.14 T045797_1 - 1.7e-24 85.1 0.0 3.8e-24 83.9 0.0 1.7 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.6 T045797_1 - 0.0014 17.8 0.0 0.025 13.7 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydro_lipase PF04083.14 T045797_2 - 2.7e-21 74.8 0.1 4.6e-21 74.0 0.1 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.18 T045797_2 - 4.8e-05 23.0 0.1 0.00027 20.5 0.1 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold zf-CCCH PF00642.22 T252698_3 - 2.5e-08 33.5 19.6 0.0018 18.0 1.1 5.2 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 T252698_3 - 2.5e-05 24.4 14.1 0.0012 18.9 1.0 3.3 3 0 0 3 3 3 2 Zinc-finger containing family zf-CCCH_2 PF14608.4 T252698_3 - 1.9 8.9 32.1 1.8 9.0 1.6 5.3 5 0 0 5 5 5 0 RNA-binding, Nab2-type zinc finger FAM47 PF14642.4 T329520_3 - 8.8e-05 22.0 1.1 0.16 11.3 0.2 2.6 1 1 2 3 3 3 2 FAM47 family adh_short PF00106.23 T363183_2 - 6.8e-48 162.6 0.1 9.9e-48 162.0 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 T363183_2 - 5.5e-23 81.6 0.0 7.8e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase TPT PF03151.14 T363183_2 - 1.4e-14 54.0 5.8 2.6e-14 53.1 5.8 1.4 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.9 T363183_2 - 2e-05 23.8 5.7 4e-05 22.8 5.7 1.4 1 0 0 1 1 1 1 UAA transporter family KR PF08659.8 T363183_2 - 0.00057 19.7 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.16 T363183_2 - 0.027 14.6 0.1 0.058 13.5 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.15 T363183_2 - 0.44 11.0 1.7 0.88 10.1 0.1 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Pkinase PF00069.23 T272792_2 - 1.3e-71 240.9 0.0 1.8e-71 240.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DCX PF03607.15 T272792_2 - 1.2e-43 146.9 0.2 1e-22 79.8 0.0 2.6 2 0 0 2 2 2 2 Doublecortin Pkinase_Tyr PF07714.15 T272792_2 - 4.2e-32 111.3 0.0 6.1e-32 110.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T272792_2 - 0.00031 20.0 0.0 0.0014 17.9 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 T272792_2 - 0.035 13.3 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TTL PF03133.13 T216056_1 - 1.9e-87 293.0 1.9 3e-87 292.4 1.9 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 T216056_1 - 3.8e-08 32.8 0.1 5.2e-05 22.5 0.0 2.8 3 1 0 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 T216056_1 - 0.0068 15.6 0.0 0.044 12.9 0.0 2.0 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp JmjC PF02373.20 T383483_3 - 1.1e-33 116.0 1.4 2.8e-33 114.6 1.4 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase TPR_1 PF00515.26 T383483_3 - 5.6e-24 82.8 19.1 1.7e-05 24.3 0.0 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 T383483_3 - 3e-13 48.6 18.9 0.16 12.0 0.1 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.4 T383483_3 - 2.3e-12 47.3 0.5 0.13 12.8 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.4 T383483_3 - 2.3e-12 45.9 17.0 0.0065 16.5 0.4 7.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.4 T383483_3 - 6.8e-12 44.8 0.2 0.01 16.0 0.0 4.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 T383483_3 - 5.7e-08 32.8 9.4 0.37 11.0 0.1 4.8 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.4 T383483_3 - 6e-06 26.5 2.7 2.7 8.9 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.4 T383483_3 - 9.7e-06 25.1 8.9 0.75 9.8 0.2 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.4 T383483_3 - 1e-05 25.8 9.5 0.075 13.4 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.4 T383483_3 - 0.00043 20.3 2.4 0.015 15.4 0.1 3.5 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.4 T383483_3 - 0.012 15.1 11.6 0.18 11.4 0.0 5.4 3 2 3 6 6 6 0 TPR repeat SNAP PF14938.4 T383483_3 - 0.073 12.3 12.4 0.04 13.2 1.1 3.0 2 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP TPR_15 PF13429.4 T383483_3 - 0.66 9.0 7.4 0.54 9.3 3.1 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.4 T383483_3 - 1 10.0 10.3 4.9 7.9 0.1 6.0 8 0 0 8 8 7 0 Tetratricopeptide repeat Abhydrolase_3 PF07859.11 T252573_3 - 1e-50 172.4 0.0 1.1e-37 129.8 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.26 T252573_3 - 1.6e-07 30.6 0.0 4.5e-07 29.0 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.7 T252573_3 - 0.04 13.3 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase Peptidase_S9 PF00326.19 T252573_3 - 0.072 12.4 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family AXE1 PF05448.10 T252573_3 - 0.1 11.1 0.0 0.19 10.3 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Esterase PF00756.18 T252573_3 - 0.11 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Band_3_cyto PF07565.11 T192016_1 - 1.9e-104 349.1 0.0 2.8e-104 348.6 0.0 1.2 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Dynactin PF12455.6 T192016_3 - 7.5e-102 340.3 4.9 7.5e-102 340.3 4.9 4.2 4 1 0 4 4 4 1 Dynein associated protein CAP_GLY PF01302.23 T192016_3 - 1.3e-22 79.4 2.4 2.8e-22 78.3 2.4 1.6 1 0 0 1 1 1 1 CAP-Gly domain Lebercilin PF15619.4 T192016_3 - 0.0028 17.2 38.4 0.0028 17.2 38.4 5.5 4 2 1 5 5 5 1 Ciliary protein causing Leber congenital amaurosis disease Fe_hyd_lg_C PF02906.12 T192016_3 - 0.55 9.7 5.9 0.79 9.2 3.9 2.4 2 0 0 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain Filament PF00038.19 T192016_3 - 1 8.7 88.5 0.95 8.8 35.6 3.6 3 0 0 3 3 3 0 Intermediate filament protein DUF4723 PF15851.3 T301114_3 - 0.018 15.0 6.7 0.032 14.2 6.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) SEA PF01390.18 T167737_1 - 0 1381.1 0.0 4.3e-28 97.6 0.0 17.2 16 0 0 16 16 16 16 SEA domain Phage_DNA_bind PF02303.15 T167737_1 - 8.3e-07 28.9 16.2 1.7e+02 2.2 0.0 12.1 14 0 0 14 14 14 0 Helix-destabilising protein Glyco_transf_92 PF01697.25 T060189_1 - 0.14 11.7 0.7 0.18 11.3 0.7 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 92 TPR_16 PF13432.4 T060189_2 - 7.5e-07 29.6 5.9 9.8e-05 22.8 1.8 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.4 T060189_2 - 1.5e-05 25.3 2.5 0.00041 20.7 1.6 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.4 T060189_2 - 4.4e-05 23.4 1.3 0.012 15.9 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.15 T060189_2 - 4.8e-05 23.0 13.7 0.00011 21.9 1.0 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 T060189_2 - 0.00033 20.5 1.3 0.0047 16.9 0.1 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_11 PF13414.4 T060189_2 - 0.00042 19.8 1.3 2 8.1 0.0 3.4 2 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.26 T060189_2 - 0.0007 19.2 13.5 0.0014 18.2 0.5 3.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 T060189_2 - 0.00089 19.0 1.9 0.61 10.1 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 T060189_2 - 0.0023 18.1 7.4 0.03 14.5 2.1 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.4 T060189_2 - 0.0048 17.3 0.4 0.0048 17.3 0.4 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.4 T060189_2 - 0.0056 16.7 1.6 0.012 15.6 1.6 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.4 T060189_2 - 0.014 16.0 6.0 0.018 15.7 1.2 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 T060189_2 - 0.18 11.8 10.2 0.29 11.1 0.4 3.2 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.5 T060189_2 - 2.3 8.4 6.3 0.29 11.2 0.8 2.0 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 RVT_1 PF00078.25 T306571_1 - 3.2e-16 59.4 0.0 4.5e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MOEP19 PF16005.3 T306571_2 - 5.1e-25 87.2 0.1 8.4e-25 86.5 0.1 1.3 1 0 0 1 1 1 1 KH-like RNA-binding domain RVT_1 PF00078.25 T306571_2 - 0.00094 18.6 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TNFR_c6 PF00020.16 T375744_2 - 3.5e-11 43.2 29.7 7.2e-07 29.4 7.6 3.7 3 0 0 3 3 3 2 TNFR/NGFR cysteine-rich region FAM27 PF15832.3 T375744_2 - 0.49 10.8 5.5 0.95 9.9 5.5 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family PH PF00169.27 T302342_1 - 1.2e-18 67.4 0.2 2.2e-18 66.6 0.2 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 T302342_1 - 0.00033 20.8 0.0 0.00072 19.7 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 T302342_1 - 0.00044 20.5 1.9 0.011 16.0 1.9 2.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.8 T302342_1 - 0.0022 18.2 0.0 0.0049 17.1 0.0 1.7 1 0 0 1 1 1 1 Plant pleckstrin homology-like region EF-hand_6 PF13405.4 T302342_1 - 0.065 13.1 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.4 T302342_1 - 0.15 12.4 0.0 0.96 9.8 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair MVL PF12151.6 T302342_1 - 0.21 11.3 4.6 0.85 9.4 0.3 2.7 2 0 0 2 2 2 0 Mannan-binding protein zf-C2H2 PF00096.24 T302342_2 - 0.00057 20.1 22.4 0.0016 18.7 1.6 4.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type CALCOCO1 PF07888.9 T232245_3 - 8.9e-06 24.4 0.1 1.6e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Exo_endo_phos PF03372.21 T232245_3 - 5e-05 23.4 0.0 8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Amino_oxidase PF01593.22 T023712_1 - 1.8e-58 198.8 0.1 2.3e-58 198.5 0.1 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 T023712_1 - 8.9e-11 41.7 0.1 2.2e-10 40.5 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 T023712_1 - 3.3e-06 26.8 0.6 0.00011 21.8 0.4 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.15 T023712_1 - 0.011 14.9 0.1 0.016 14.3 0.1 1.1 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.5 T023712_1 - 0.027 13.7 0.1 0.036 13.3 0.1 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 T023712_1 - 0.065 12.2 0.1 0.093 11.7 0.1 1.1 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.12 T023712_1 - 0.09 11.9 0.0 0.28 10.2 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase UCH PF00443.27 T023712_2 - 3.1e-60 203.7 0.0 3.9e-60 203.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 T023712_2 - 2.4e-17 63.4 0.0 3.9e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UFC1 PF08694.9 T023712_3 - 4.7e-84 279.5 0.1 8.3e-84 278.7 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 FAM176 PF14851.4 T225105_3 - 4.8e-53 178.6 0.0 6.9e-53 178.1 0.0 1.2 1 0 0 1 1 1 1 FAM176 family Gal_Lectin PF02140.16 T225105_3 - 4.7e-38 129.4 11.9 3.2e-19 69.0 1.7 2.6 2 0 0 2 2 2 2 Galactose binding lectin domain 7tm_1 PF00001.19 T005362_3 - 8.3e-76 254.6 11.8 1.2e-75 254.1 11.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T005362_3 - 2.3e-09 36.9 6.7 4.5e-09 35.9 6.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 T005362_3 - 0.00019 21.1 12.4 0.0042 16.7 10.1 2.7 2 1 0 2 2 2 2 Olfactory receptor Ank PF00023.28 T199666_1 - 2.1e-13 49.9 0.4 0.00048 20.3 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.5 T199666_1 - 2.6e-13 50.2 0.4 4.7e-13 49.4 0.4 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T199666_1 - 4.3e-12 46.2 0.2 3.5e-06 27.3 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 T199666_1 - 3.9e-11 42.9 1.5 8.3e-06 25.9 0.1 2.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 T199666_1 - 1.3e-09 37.3 0.6 0.0067 16.7 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat 7tm_1 PF00001.19 T067516_1 - 2.2e-85 286.0 8.9 3.3e-85 285.4 8.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T067516_1 - 1.3e-14 54.1 22.8 4.7e-12 45.7 15.2 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 T067516_1 - 0.021 14.0 23.3 0.31 10.2 16.3 2.2 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 T067516_1 - 0.15 11.7 17.6 0.0062 16.2 11.7 1.6 2 0 0 2 2 2 0 Olfactory receptor Rifin_STEVOR PF02009.14 T067516_1 - 0.35 10.6 1.0 0.55 9.9 1.0 1.2 1 0 0 1 1 1 0 Rifin/stevor family Macro PF01661.19 T214061_2 - 2.6e-19 69.3 0.0 3.8e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 Macro domain GDPD PF03009.15 T064467_3 - 2.7e-18 66.5 0.0 4e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Y_phosphatase PF00102.25 T050661_1 - 4.3e-166 550.0 6.6 7.7e-84 280.8 0.4 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.18 T050661_1 - 7.6e-10 38.6 0.2 0.00021 21.0 0.1 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 T050661_1 - 1e-07 32.0 0.2 0.012 15.5 0.0 2.6 3 0 0 3 3 3 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 T050661_1 - 6.6e-06 26.2 0.1 0.031 14.3 0.1 2.7 2 0 0 2 2 2 2 Inositol hexakisphosphate Y_phosphatase2 PF03162.11 T050661_1 - 0.021 14.3 0.0 2.3 7.7 0.0 2.5 2 0 0 2 2 2 0 Tyrosine phosphatase family Yae1_N PF09811.7 T062779_1 - 2.1e-10 40.0 5.2 2.1e-10 40.0 5.2 1.8 2 0 0 2 2 2 1 Essential protein Yae1, N terminal PP28 PF10252.7 T329059_1 - 3.8e-29 100.8 17.2 3.8e-29 100.8 17.2 2.3 2 0 0 2 2 2 1 Casein kinase substrate phosphoprotein PP28 C2 PF00168.28 T349060_1 - 9.6e-37 125.3 0.2 6.1e-19 68.1 0.0 2.9 3 0 0 3 3 3 2 C2 domain FYVE_2 PF02318.14 T349060_1 - 1e-09 38.5 19.8 1.5e-09 37.9 10.2 2.5 2 0 0 2 2 2 2 FYVE-type zinc finger PDZ PF00595.22 T349060_1 - 1.5e-05 25.1 0.0 3e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) TSNAXIP1_N PF15739.3 T134841_2 - 2.1e-05 24.7 2.9 2.1e-05 24.7 2.9 3.3 3 1 1 4 4 4 1 Translin-associated factor X-interacting N-terminus XH PF03469.12 T134841_2 - 0.017 14.9 0.2 0.017 14.9 0.2 2.4 2 0 0 2 2 2 0 XH domain IncA PF04156.12 T134841_2 - 0.71 9.5 17.5 0.52 9.9 0.2 3.3 3 0 0 3 3 3 0 IncA protein DUF4600 PF15372.4 T134841_2 - 1.4 9.2 21.0 0.48 10.7 2.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4600) MRP-L47 PF06984.11 T134841_2 - 1.8 8.6 7.5 8.4 6.5 0.3 3.3 3 0 0 3 3 3 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ig_3 PF13927.4 T022879_2 - 7.3e-24 84.1 1.3 1e-07 32.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T022879_2 - 1.2e-21 76.7 1.0 2e-06 27.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T022879_2 - 1.8e-15 56.7 2.3 6e-09 35.8 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 T022879_2 - 1.9e-07 30.9 0.0 3.6e-05 23.6 0.0 3.6 3 2 0 3 3 3 1 Immunoglobulin I-set domain V-set PF07686.15 T022879_2 - 0.00044 20.3 2.3 3 7.9 0.1 5.4 3 3 0 4 4 4 1 Immunoglobulin V-set domain Ig_5 PF16681.3 T022879_2 - 0.0018 18.5 0.0 0.84 10.0 0.0 3.2 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Thionin PF00321.15 T022879_2 - 0.053 13.9 0.2 0.11 12.9 0.2 1.6 1 0 0 1 1 1 0 Plant thionin CortBP2 PF09727.7 T331812_2 - 7.1e-39 133.6 40.5 4.2e-32 111.5 1.5 3.4 2 1 1 3 3 3 3 Cortactin-binding protein-2 Ank_2 PF12796.5 T331812_2 - 8.1e-38 128.8 7.0 2e-18 66.6 2.7 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T331812_2 - 3.4e-35 119.8 9.4 4.9e-13 49.2 0.1 5.2 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 T331812_2 - 3.1e-23 81.0 5.9 5e-05 23.4 0.0 6.1 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.4 T331812_2 - 3.4e-23 81.2 9.2 1.3e-07 31.6 0.1 5.7 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 T331812_2 - 5.3e-19 66.2 3.4 0.0034 17.6 0.0 6.9 6 0 0 6 6 6 5 Ankyrin repeat DUF4407 PF14362.4 T331812_2 - 0.62 9.2 13.6 1.2 8.2 13.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Bacillus_HBL PF05791.9 T331812_2 - 0.98 9.0 7.3 2.5 7.7 7.3 1.6 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Spc7 PF08317.9 T331812_2 - 1 8.0 32.4 2.3 6.9 32.4 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2347 PF09804.7 T331812_2 - 4.2 6.7 6.7 8.3 5.8 6.7 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Gar1 PF04410.12 T273887_2 - 1.3e-07 31.4 3.2 2.2e-07 30.7 3.2 1.2 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region TRAPP PF04051.14 T167294_1 - 3.4e-16 59.1 0.0 6.2e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Lectin_N PF03954.12 T167294_1 - 0.0034 17.0 0.4 0.0072 15.9 0.1 1.6 2 0 0 2 2 2 1 Hepatic lectin, N-terminal domain HEAT_EZ PF13513.4 T290208_2 - 0.032 14.6 6.7 0.076 13.4 0.6 3.2 3 0 0 3 3 3 0 HEAT-like repeat TPR_5 PF12688.5 T290208_2 - 0.11 12.5 0.6 0.28 11.3 0.6 1.6 1 0 0 1 1 1 0 Tetratrico peptide repeat HEAT PF02985.20 T290208_2 - 0.17 12.1 1.0 9.4 6.7 0.2 3.8 3 0 0 3 3 3 0 HEAT repeat Arm PF00514.21 T290208_2 - 3.3 7.8 27.8 0.11 12.4 0.4 6.7 8 0 0 8 8 8 0 Armadillo/beta-catenin-like repeat WAPL PF07814.11 T290208_2 - 8.3 5.0 9.3 55 2.3 5.2 3.4 1 1 1 2 2 2 0 Wings apart-like protein regulation of heterochromatin FAA_hydrolase PF01557.16 T120545_2 - 5.6e-56 189.5 0.0 7.6e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.9 T120545_2 - 2.6e-31 107.8 0.0 3.9e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal 7tm_1 PF00001.19 T124736_1 - 3.3e-59 200.2 17.8 4.5e-59 199.7 17.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T124736_1 - 2.2e-11 43.5 7.5 2.7e-11 43.2 7.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 T124736_1 - 0.0039 16.4 5.2 0.0063 15.7 5.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.7 T124736_1 - 0.017 14.3 5.9 0.24 10.5 5.9 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 T124736_1 - 0.024 13.8 7.1 0.036 13.3 7.1 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv PNRC PF15365.4 T124736_2 - 0.015 15.7 1.6 0.015 15.7 1.6 3.0 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator Kinesin PF00225.21 T315704_2 - 5.1e-23 81.4 0.1 1e-16 60.6 0.2 2.8 1 1 1 2 2 2 2 Kinesin motor domain Ras PF00071.20 T124275_1 - 8.2e-19 67.6 0.0 1.2e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 Ras family SOCS_box PF07525.14 T124275_1 - 2.9e-06 27.4 2.1 5.7e-06 26.4 0.4 2.6 2 0 0 2 2 2 1 SOCS box Roc PF08477.11 T124275_1 - 0.044 13.9 0.0 0.069 13.2 0.0 1.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Kunitz_BPTI PF00014.21 T124275_2 - 3.9e-25 87.7 7.6 2.1e-17 62.9 1.7 2.6 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Ig_3 PF13927.4 T124275_2 - 3.5e-15 56.3 0.1 8.8e-15 55.0 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T124275_2 - 2.9e-14 52.7 0.0 4.6e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 T124275_2 - 2.7e-10 40.3 0.0 7e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T124275_2 - 4e-09 36.4 0.0 9.7e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain WAP PF00095.19 T124275_2 - 4e-08 33.4 10.8 4e-08 33.4 10.8 4.1 3 0 0 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' V-set PF07686.15 T124275_2 - 3e-05 24.0 0.0 7.6e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain Kazal_2 PF07648.13 T124275_2 - 0.0001 22.3 0.8 0.00039 20.4 0.5 2.2 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Dynein_IC2 PF11540.6 T328633_3 - 1.1e-14 53.9 0.1 2.6e-14 52.7 0.1 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 T328633_3 - 3.9e-06 27.4 8.3 0.18 12.6 0.3 5.9 7 0 0 7 7 7 2 WD domain, G-beta repeat Caldesmon PF02029.13 T027812_2 - 3.8e-14 52.2 35.6 4.1e-08 32.3 1.8 2.1 2 0 0 2 2 2 2 Caldesmon Troponin PF00992.18 T027812_3 - 4e-33 114.4 50.3 7.9e-31 107.0 36.6 3.2 2 1 1 3 3 3 2 Troponin DUF1800 PF08811.9 T027812_3 - 0.36 9.6 6.0 0.55 9.0 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) SH3_2 PF07653.15 T143218_1 - 4.2e-06 26.2 0.0 9.2e-06 25.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain MyTH4 PF00784.15 T143218_3 - 5.4e-25 87.8 0.1 1.4e-24 86.5 0.1 1.7 1 0 0 1 1 1 1 MyTH4 domain 2OG-FeII_Oxy_2 PF13532.4 T143218_3 - 1.3e-08 35.1 0.0 2.7e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily FERM_M PF00373.16 T143218_3 - 2.1e-07 31.2 0.6 4.1e-07 30.3 0.6 1.5 1 0 0 1 1 1 1 FERM central domain SH3_2 PF07653.15 T143218_3 - 0.0032 17.0 0.0 0.0069 15.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain zf-H2C2_2 PF13465.4 T171779_1 - 3.7e-13 49.1 26.2 0.00064 19.9 1.3 5.9 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 T171779_1 - 0.013 15.8 25.0 0.14 12.6 0.2 5.5 5 0 0 5 5 5 0 Zinc finger, C2H2 type XPA_N PF01286.16 T171779_1 - 0.19 11.7 13.0 3 7.8 0.1 4.6 4 0 0 4 4 4 0 XPA protein N-terminal Zn-ribbon_8 PF09723.8 T171779_1 - 0.91 9.6 16.0 0.96 9.5 1.5 3.1 2 1 1 3 3 3 0 Zinc ribbon domain zf-H2C2_2 PF13465.4 T171779_3 - 1e-91 297.5 127.8 1e-08 35.1 1.0 17.3 16 0 0 16 16 16 15 Zinc-finger double domain zf-C2H2 PF00096.24 T171779_3 - 3.8e-57 187.5 96.2 8.1e-06 25.9 0.5 16.4 15 0 0 15 15 15 14 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 T171779_3 - 1.1e-26 92.1 88.1 0.00062 19.5 2.3 15.0 14 0 0 14 14 14 11 C2H2-type zinc finger zf-C2H2_4 PF13894.4 T171779_3 - 8.4e-25 85.2 97.6 0.02 15.6 0.5 16.1 15 0 0 15 15 15 13 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T171779_3 - 1.1e-12 47.4 44.1 0.28 10.8 0.0 14.5 15 0 0 15 15 15 7 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T171779_3 - 1.3e-12 47.5 78.3 0.048 13.6 3.9 10.7 7 4 6 13 13 13 12 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T171779_3 - 8.2e-11 41.8 67.4 0.27 11.5 0.0 14.5 14 0 0 14 14 14 6 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 T171779_3 - 2.2e-08 33.8 75.1 4.1 7.4 0.2 14.7 14 0 0 14 14 14 8 XPA protein N-terminal zf-C2H2_8 PF15909.3 T171779_3 - 0.00014 22.0 56.2 0.27 11.4 1.3 7.9 1 1 7 8 8 8 7 C2H2-type zinc ribbon zf-trcl PF13451.4 T171779_3 - 0.07 12.9 69.7 0.71 9.7 0.1 13.0 11 2 1 12 12 12 0 Probable zinc-ribbon domain Collagen PF01391.16 T208948_2 - 6e-184 595.9 729.4 1.8e-09 37.1 20.3 26.7 8 7 19 27 27 27 26 Collagen triple helix repeat (20 copies) C4 PF01413.17 T208948_2 - 2.4e-79 262.8 1.4 7e-41 138.9 0.1 2.2 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen RhoGEF PF00621.18 T249407_1 - 2.4e-72 242.8 8.9 3e-38 131.8 2.4 5.1 5 1 1 6 6 5 2 RhoGEF domain Spectrin PF00435.19 T249407_1 - 5.2e-39 132.8 85.7 2.3e-09 37.5 1.7 9.9 8 2 1 9 9 9 6 Spectrin repeat SH3-RhoG_link PF16609.3 T249407_1 - 1.1e-36 126.8 13.5 4e-35 121.7 13.5 2.5 1 1 0 1 1 1 1 SH3-RhoGEF linking unstructured region PH PF00169.27 T249407_1 - 6.6e-13 48.9 1.0 1.6e-05 25.2 0.1 3.2 3 0 0 3 3 3 2 PH domain PH_10 PF15411.4 T249407_1 - 1.3e-07 31.8 0.1 0.034 14.3 0.0 3.4 2 0 0 2 2 2 2 Pleckstrin homology domain CRAL_TRIO_2 PF13716.4 T249407_1 - 2.7e-07 30.6 0.0 3e-05 24.0 0.0 2.7 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain SH3_1 PF00018.26 T249407_1 - 6e-07 28.8 0.0 7.6e-05 22.1 0.0 2.8 2 0 0 2 2 2 1 SH3 domain CRAL_TRIO PF00650.18 T249407_1 - 1.5e-06 27.9 0.1 6.1e-06 25.9 0.0 2.1 2 0 0 2 2 2 1 CRAL/TRIO domain SH3_9 PF14604.4 T249407_1 - 8.9e-06 25.3 0.2 7.1e-05 22.5 0.0 2.6 3 0 0 3 3 3 1 Variant SH3 domain SH3_2 PF07653.15 T249407_1 - 3e-05 23.5 0.0 0.0031 17.0 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain PH_13 PF16652.3 T249407_1 - 0.00045 20.0 1.9 0.51 10.1 0.1 3.0 3 0 0 3 3 3 2 Pleckstrin homology domain HAD_2 PF13419.4 T249407_1 - 3.4 7.6 9.6 1.9 8.4 0.3 3.6 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase LRR_4 PF12799.5 T071411_3 - 7.3e-11 42.0 22.4 0.2 12.0 0.7 7.2 6 1 0 7 7 7 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 T071411_3 - 5.6e-10 38.3 43.8 0.018 14.9 0.2 10.9 11 0 0 11 11 11 5 Leucine Rich repeat F-box-like PF12937.5 T071411_3 - 7.4e-08 32.0 1.3 1.2e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 T071411_3 - 7.2e-06 25.6 0.2 2.5e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 F-box domain Ste50p-SAM PF09235.8 T071411_3 - 0.17 12.0 1.4 0.76 9.9 0.3 2.5 2 1 1 3 3 3 0 Ste50p, sterile alpha motif LRR_2 PF07723.11 T071411_3 - 0.7 10.5 6.4 2.6 8.7 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_1 PF00560.31 T071411_3 - 2.4 8.8 27.6 60 4.6 0.1 9.4 9 0 0 9 9 9 0 Leucine Rich Repeat Neur_chan_LBD PF02931.21 T113253_2 - 3.3e-48 163.8 0.9 4.4e-48 163.4 0.9 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Methyltransf_11 PF08241.10 T213979_3 - 1.5e-18 67.0 0.0 5.2e-18 65.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 T213979_3 - 8.1e-14 52.0 0.0 2.9e-13 50.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.4 T213979_3 - 9.7e-14 51.5 0.0 2.2e-13 50.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.10 T213979_3 - 4.3e-10 40.1 0.0 9.3e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T213979_3 - 5.9e-10 39.0 0.0 1.7e-09 37.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.16 T213979_3 - 1.5e-06 27.6 0.0 2.5e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 T213979_3 - 0.039 13.4 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain MetW PF07021.10 T213979_3 - 0.039 13.4 0.0 0.065 12.7 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Transglut_core2 PF13369.4 T087328_1 - 1.5e-39 134.9 0.0 2.1e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase-like superfamily YccV-like PF08755.9 T087328_1 - 1.3e-28 99.2 0.4 3.4e-28 97.9 0.1 1.8 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like F-box-like PF12937.5 T087328_1 - 3.9e-05 23.3 0.1 0.00024 20.8 0.0 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 T087328_1 - 0.0047 16.6 0.3 0.015 15.0 0.3 1.9 1 0 0 1 1 1 1 F-box domain SAPS PF04499.13 T062407_2 - 7.7e-104 348.1 10.9 1e-65 222.3 5.2 3.3 3 1 1 4 4 4 2 SIT4 phosphatase-associated protein 7tm_1 PF00001.19 T024654_3 - 4e-44 150.7 17.9 7.9e-44 149.8 17.9 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 T024654_3 - 0.00087 18.5 14.3 0.0016 17.7 14.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx BCAS3 PF12490.6 T151740_2 - 9.4e-26 90.6 0.0 1.4e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 3 WD40 PF00400.30 T151740_2 - 0.0041 17.8 2.3 0.48 11.2 0.1 3.3 2 0 0 2 2 2 2 WD domain, G-beta repeat Integrin_alpha2 PF08441.10 T130286_1 - 5.2e-38 131.0 0.0 7.4e-38 130.5 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 T130286_1 - 7.1e-19 68.6 0.1 1.1e-18 68.0 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 T130286_1 - 2.5e-18 65.7 7.8 6.4e-08 32.5 0.4 4.0 4 0 0 4 4 4 3 FG-GAP repeat VCBS PF13517.4 T130286_1 - 1.6e-08 34.8 0.2 1.5e-05 25.3 0.1 2.8 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 T130286_1 - 0.00017 21.2 0.4 0.00042 20.0 0.4 1.7 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.4 T130286_1 - 0.00023 21.2 10.1 0.066 13.3 0.0 4.6 4 0 0 4 4 4 2 FG-GAP repeat VWA_2 PF13519.4 T130286_1 - 0.0055 17.2 0.1 0.019 15.5 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain Somatomedin_B PF01033.15 T026580_1 - 1.3e-19 70.2 43.7 2.6e-10 40.4 17.9 2.5 2 0 0 2 2 2 2 Somatomedin B domain Hemopexin PF00045.17 T026580_1 - 2.3e-13 49.7 7.4 1.3e-09 37.7 0.2 3.8 4 0 0 4 4 4 2 Hemopexin Vasculin PF15337.4 T010166_1 - 6.8e-43 145.4 3.7 1.3e-42 144.5 3.7 1.5 1 0 0 1 1 1 1 Vascular protein family Vasculin-like 1 AbLIM_anchor PF16182.3 T340189_1 - 9.9e-82 275.6 14.7 9.9e-82 275.6 14.7 2.6 2 1 0 2 2 2 1 Putative adherens-junction anchoring region of AbLIM FGF PF00167.16 T340189_1 - 6.2e-39 132.8 0.1 2.1e-38 131.1 0.7 1.6 2 0 0 2 2 2 1 Fibroblast growth factor Nucleoplasmin PF03066.13 T340189_1 - 4.7e-34 116.8 0.0 8.5e-34 116.0 0.0 1.4 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain VHP PF02209.17 T340189_1 - 5.2e-14 51.9 0.8 1.2e-13 50.8 0.8 1.7 1 0 0 1 1 1 1 Villin headpiece domain YL1 PF05764.11 T340189_1 - 0.0021 18.1 6.1 0.0021 18.1 6.1 2.4 2 0 0 2 2 2 1 YL1 nuclear protein MPP6 PF10175.7 T340189_1 - 3.5 8.0 10.8 8.8 6.7 3.7 2.5 2 0 0 2 2 2 0 M-phase phosphoprotein 6 zf-H2C2_2 PF13465.4 T345638_3 - 2.3e-08 34.0 27.9 5.6e-06 26.4 0.5 4.6 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 T345638_3 - 4.6e-08 33.0 34.5 2.6e-05 24.3 6.5 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T345638_3 - 6e-05 23.4 29.4 0.079 13.7 1.8 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger SET PF00856.26 T345638_3 - 0.00055 20.2 0.1 0.0013 19.0 0.1 1.6 1 1 0 1 1 1 1 SET domain zf-C2H2_11 PF16622.3 T345638_3 - 0.001 18.7 5.3 0.001 18.7 5.3 4.3 6 0 0 6 6 6 1 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 T345638_3 - 2.8 7.9 28.0 0.32 10.8 5.4 4.1 5 0 0 5 5 5 0 C2H2-type zinc finger PTB PF08416.11 T016981_2 - 1.4e-38 131.8 0.1 2e-38 131.4 0.1 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SH3_1 PF00018.26 T016981_3 - 2.2e-11 43.0 0.0 6e-11 41.6 0.0 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 T016981_3 - 2.1e-07 30.6 0.0 4.6e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T016981_3 - 4.1e-06 26.2 0.0 7.1e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 T016981_3 - 0.00063 19.8 0.1 0.0012 19.0 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain hSH3 PF14603.4 T016981_3 - 0.02 15.3 0.0 0.038 14.4 0.0 1.4 1 0 0 1 1 1 0 Helically-extended SH3 domain FAM27 PF15832.3 T255412_1 - 0.0013 19.1 5.8 0.0026 18.1 5.8 1.4 1 0 0 1 1 1 1 FAM27 D and E protein family FAM27 PF15832.3 T255412_2 - 0.0034 17.8 6.7 0.015 15.7 6.7 2.1 1 0 0 1 1 1 1 FAM27 D and E protein family FAM27 PF15832.3 T255412_3 - 0.075 13.4 12.1 0.16 12.4 12.1 1.5 1 0 0 1 1 1 0 FAM27 D and E protein family Period_C PF12114.6 T141324_2 - 3.3e-76 255.1 2.5 3.3e-76 255.1 2.5 3.7 4 0 0 4 4 4 1 Period protein 2/3C-terminal region PAS_3 PF08447.10 T141324_2 - 3.1e-11 43.3 0.0 7.8e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.4 T141324_2 - 4.8e-08 33.0 0.0 1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS PF00989.23 T141324_2 - 4.6e-07 29.7 0.0 0.00029 20.7 0.0 2.4 2 0 0 2 2 2 2 PAS fold DUF4618 PF15397.4 T212155_1 - 4.7e-75 252.2 27.4 6.3e-75 251.8 27.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Leu_zip PF15294.4 T212155_1 - 0.1 11.9 19.9 0.15 11.4 19.9 1.1 1 0 0 1 1 1 0 Leucine zipper DASH_Hsk3 PF08227.9 T212155_1 - 0.87 9.9 8.8 0.077 13.2 0.6 3.1 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like DUF4407 PF14362.4 T212155_1 - 2.4 7.3 10.0 3.8 6.6 10.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.13 T212155_1 - 2.8 7.3 12.9 4.4 6.6 12.9 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2681 PF10883.6 T212155_1 - 6.4 7.1 12.3 3.2 8.1 9.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF4618 PF15397.4 T212155_2 - 2.9e-25 89.0 3.8 3.8e-25 88.7 3.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) ELMO_CED12 PF04727.11 T066916_2 - 4.4e-45 153.8 0.4 6.7e-45 153.2 0.4 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family CALM_bind PF16025.3 T128258_2 - 1.9e-25 88.9 17.0 1.5e-19 70.1 1.2 3.1 3 0 0 3 3 3 2 Calcium-dependent calmodulin binding Fez1 PF06818.13 T143771_3 - 0.0042 17.4 1.9 0.0042 17.4 1.9 4.3 2 1 2 4 4 4 1 Fez1 Cytochrom_C_2 PF01322.18 T143771_3 - 4.9 7.9 9.4 2.5 8.9 2.3 2.6 2 0 0 2 2 2 0 Cytochrome C' Yip1 PF04893.15 T187392_2 - 2.1e-09 37.2 16.3 3.7e-09 36.4 16.3 1.4 1 0 0 1 1 1 1 Yip1 domain DUF4801 PF16059.3 T265121_1 - 0.41 10.5 6.3 0.51 10.2 1.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4801) Arf PF00025.19 T265121_2 - 2e-18 66.4 0.0 3.7e-08 32.9 0.0 2.2 1 1 1 2 2 2 2 ADP-ribosylation factor family Roc PF08477.11 T265121_2 - 0.008 16.3 0.0 0.027 14.6 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 T265121_2 - 0.0099 15.4 0.0 0.46 9.9 0.0 2.2 1 1 1 2 2 2 1 Ras family SRPRB PF09439.8 T265121_2 - 0.054 12.8 0.0 0.054 12.8 0.0 2.4 2 1 1 3 3 3 0 Signal recognition particle receptor beta subunit MIP-T3 PF10243.7 T265121_2 - 0.15 10.6 28.2 0.21 10.1 28.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF4778 PF16008.3 T265121_2 - 0.19 11.6 7.7 0.27 11.1 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) NPR3 PF03666.11 T265121_2 - 1.5 7.4 13.5 2 7.0 13.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Atg14 PF10186.7 T265121_2 - 1.8 7.4 13.9 2.6 6.9 13.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 EGF PF00008.25 T019231_1 - 1.2e-28 98.9 81.5 3e-07 30.5 5.3 7.3 6 0 0 6 6 6 6 EGF-like domain EGF_CA PF07645.13 T019231_1 - 7.6e-08 32.3 6.2 7.6e-08 32.3 6.2 6.5 3 1 3 6 6 6 1 Calcium-binding EGF domain hEGF PF12661.5 T019231_1 - 8e-06 26.2 90.8 1.4e-05 25.4 6.4 8.8 7 1 0 7 7 7 5 Human growth factor-like EGF DUF1220 PF06758.11 T019231_2 - 5.1e-161 523.1 74.1 1.1e-26 92.8 7.2 7.6 7 0 0 7 7 7 7 Repeat of unknown function (DUF1220) GAT PF03127.12 T019231_2 - 0.00072 19.7 8.5 0.11 12.7 1.0 2.6 2 0 0 2 2 2 2 GAT domain TPR_12 PF13424.4 T280846_2 - 0.086 13.0 12.4 0.017 15.3 3.4 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat His_Phos_2 PF00328.20 T115505_2 - 8.5e-66 222.7 0.0 1.2e-65 222.3 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.9 T115505_2 - 0.095 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 RimK-like ATP-grasp domain His_Phos_2 PF00328.20 T115505_3 - 3.3e-61 207.6 0.1 3.3e-61 207.6 0.1 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) A_deamin PF02137.16 T270711_1 - 1e-79 268.2 0.1 1.4e-79 267.8 0.1 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 T270711_1 - 5.2e-11 42.9 0.2 3.6e-10 40.3 0.0 2.2 2 0 0 2 2 2 1 Double-stranded RNA binding motif TNFR_c6 PF00020.16 T091476_2 - 1.9e-05 24.8 18.6 0.00036 20.7 3.4 4.8 5 0 0 5 5 5 2 TNFR/NGFR cysteine-rich region NO_synthase PF02898.13 T144409_2 - 2.1e-185 615.9 0.0 2.7e-185 615.5 0.0 1.1 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 T144409_2 - 2.7e-83 278.8 0.0 3.9e-83 278.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 T144409_2 - 1.4e-41 141.9 0.0 2.6e-41 141.0 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 T144409_2 - 2.8e-22 79.3 0.0 5.3e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Paxillin PF03535.11 T087605_2 - 4.3e-93 310.7 18.8 7.3e-93 310.0 18.8 1.4 1 0 0 1 1 1 1 Paxillin family LIM PF00412.20 T087605_2 - 5.8e-65 215.2 37.7 8.6e-18 64.2 2.1 4.3 4 0 0 4 4 4 4 LIM domain C2-set_2 PF08205.10 T176994_1 - 4.6e-20 71.4 0.2 4.6e-20 71.4 0.2 2.4 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 T176994_1 - 1.4e-11 44.7 2.4 0.0042 17.5 0.0 4.0 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T176994_1 - 3.9e-10 39.6 0.7 0.011 15.8 0.0 4.1 4 1 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 T176994_1 - 7.7e-10 38.8 0.1 9.8e-09 35.2 0.0 2.7 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T176994_1 - 0.00065 19.9 0.6 2.2 8.6 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 T176994_1 - 0.001 18.9 0.0 1.2 9.1 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.15 T176994_3 - 1.1e-06 28.7 0.0 2.3e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Solute_trans_a PF03619.14 T317308_1 - 1.5e-21 77.0 1.1 2.3e-21 76.4 1.1 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha PAC3 PF10178.7 T317308_2 - 1.1e-25 89.4 0.1 1.9e-25 88.7 0.1 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 Solute_trans_a PF03619.14 T317308_3 - 1.8e-55 188.3 3.1 3.7e-37 128.2 0.2 2.1 2 0 0 2 2 2 2 Organic solute transporter Ostalpha TPR_19 PF14559.4 T203663_2 - 1.4e-12 47.8 16.3 0.00066 20.0 0.0 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 T203663_2 - 1.8e-09 36.8 17.3 0.0052 16.7 1.7 7.4 7 0 0 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.5 T203663_2 - 0.00011 22.2 16.9 0.0059 16.7 5.6 3.7 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.26 T203663_2 - 0.0047 16.6 21.3 0.34 10.7 2.5 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.4 T203663_2 - 0.013 16.0 15.2 0.13 12.9 0.3 3.2 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.4 T203663_2 - 0.023 15.2 5.3 0.62 10.7 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat YfiO PF13525.4 T203663_2 - 0.046 13.3 2.4 1.8 8.1 0.1 2.5 2 0 0 2 2 2 0 Outer membrane lipoprotein TPR_7 PF13176.4 T203663_2 - 0.11 12.4 12.1 1.5 8.9 1.4 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.4 T203663_2 - 0.28 12.0 6.5 40 5.3 1.8 4.5 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.4 T203663_2 - 0.79 9.9 16.4 15 5.9 2.2 5.6 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.4 T203663_2 - 1.7 8.9 12.5 42 4.6 0.6 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat PDEase_I PF00233.17 T203663_3 - 3.8e-23 82.3 0.0 5.5e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase ING PF12998.5 T211788_2 - 5.4e-31 107.1 5.5 7.2e-31 106.6 5.5 1.2 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding Spc7 PF08317.9 T211788_2 - 0.062 12.0 2.1 0.091 11.5 2.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein MgtE PF01769.14 T085542_1 - 6.5e-51 171.7 19.7 5.3e-29 101.0 1.3 2.8 3 0 0 3 3 3 2 Divalent cation transporter GTF2I PF02946.12 T326507_1 - 1.5e-184 598.3 12.3 1.9e-31 107.8 0.0 6.3 6 0 0 6 6 6 6 GTF2I-like repeat PP1_inhibitor PF05361.10 T114868_1 - 4.2e-23 81.8 0.2 6.9e-23 81.1 0.2 1.3 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor Dynein_heavy PF03028.13 T243388_1 - 1.4e-167 558.9 0.0 2.3e-166 554.9 0.0 2.6 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.11 T243388_1 - 2.8e-144 481.0 14.5 2.8e-144 481.0 14.5 3.2 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 T243388_1 - 4.3e-99 330.8 0.1 1.3e-98 329.3 0.0 1.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.5 T243388_1 - 7.7e-92 306.2 0.4 5.3e-90 300.2 0.7 2.9 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 T243388_1 - 8.8e-82 274.1 0.1 2.2e-81 272.9 0.1 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.5 T243388_1 - 2.5e-52 177.9 3.7 4.4e-52 177.1 3.7 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.5 T243388_1 - 4.7e-51 173.6 0.0 1.3e-50 172.1 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.12 T243388_1 - 3e-17 62.8 0.0 5.9e-06 26.2 0.0 6.0 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.4 T243388_1 - 7.4e-09 36.1 0.1 0.12 12.7 0.0 6.4 5 0 0 5 5 5 1 AAA domain AAA_16 PF13191.4 T243388_1 - 4.4e-08 33.6 0.1 0.37 11.0 0.0 5.2 4 0 0 4 4 4 1 AAA ATPase domain AAA PF00004.27 T243388_1 - 6.1e-08 33.0 1.1 2.7 8.3 0.0 5.5 6 0 0 6 6 5 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 T243388_1 - 7.9e-08 32.5 0.1 0.52 10.5 0.0 5.0 4 0 0 4 4 4 2 AAA domain RNA_helicase PF00910.20 T243388_1 - 0.00024 21.3 0.2 3 8.2 0.0 4.6 4 0 0 4 4 3 1 RNA helicase T2SSE PF00437.18 T243388_1 - 0.00032 19.7 4.3 0.43 9.4 0.0 3.7 4 0 0 4 4 4 2 Type II/IV secretion system protein ResIII PF04851.13 T243388_1 - 0.00084 19.2 0.0 1.3 8.9 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ABC_tran PF00005.25 T243388_1 - 0.00086 19.7 0.4 0.21 12.0 0.0 3.7 3 0 0 3 3 3 1 ABC transporter AAA_33 PF13671.4 T243388_1 - 0.00099 19.1 0.2 0.98 9.4 0.1 3.6 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.19 T243388_1 - 0.0011 18.2 0.5 0.24 10.6 0.0 3.7 4 0 0 4 4 3 1 Magnesium chelatase, subunit ChlI DEAD PF00270.27 T243388_1 - 0.0045 16.7 0.1 5.7 6.5 0.0 3.6 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_30 PF13604.4 T243388_1 - 0.012 15.2 4.0 4.6 6.8 0.1 3.5 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.4 T243388_1 - 0.015 15.5 1.3 6.8 6.9 0.0 4.2 4 0 0 4 4 3 0 AAA domain Cytidylate_kin PF02224.16 T243388_1 - 0.016 14.8 0.3 1 8.9 0.0 3.3 4 0 0 4 4 3 0 Cytidylate kinase AAA_29 PF13555.4 T243388_1 - 0.026 14.1 3.3 0.2 11.2 0.0 3.2 3 0 0 3 3 3 0 P-loop containing region of AAA domain Seryl_tRNA_N PF02403.20 T243388_1 - 0.045 13.8 0.0 0.045 13.8 0.0 4.7 5 0 0 5 5 2 0 Seryl-tRNA synthetase N-terminal domain T2SSM PF04612.10 T243388_1 - 0.066 13.1 0.0 0.32 10.9 0.0 2.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M TsaE PF02367.15 T243388_1 - 0.19 11.6 3.9 3.9 7.4 0.1 3.8 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.14 T243388_1 - 0.42 9.9 4.0 1.3 8.3 0.0 3.2 3 0 0 3 3 3 0 PhoH-like protein Sec34 PF04136.13 T243388_1 - 0.6 9.8 7.2 2.1 8.1 0.0 4.5 4 0 0 4 4 3 0 Sec34-like family AAA_25 PF13481.4 T243388_1 - 1.8 8.0 5.8 3.5 7.0 0.1 3.2 3 0 0 3 3 3 0 AAA domain Alanine_zipper PF11839.6 T243388_1 - 2 8.6 8.8 7.6 6.8 8.8 2.0 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein ISG65-75 PF11727.6 T243388_1 - 3.3 6.7 9.7 8.1 5.5 9.7 1.6 1 0 0 1 1 1 0 Invariant surface glycoprotein SesA PF17107.3 T243388_1 - 6.7 6.8 7.7 4.7 7.3 0.1 4.5 4 0 0 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Dynein_heavy PF03028.13 T243388_2 - 2.3e-47 161.6 0.2 3.4e-47 161.0 0.2 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Dynein_heavy PF03028.13 T243388_3 - 8.1e-37 126.7 0.0 1e-36 126.3 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Pkinase PF00069.23 T138778_1 - 4.5e-52 176.9 0.0 8.8e-35 120.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 T138778_1 - 1.6e-23 83.2 0.0 8.5e-22 77.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 T138778_1 - 0.037 13.2 0.1 0.1 11.7 0.1 1.7 1 1 0 1 1 1 0 Kinase-like DUF4609 PF15382.4 T138778_2 - 2.8e-39 132.7 1.3 5e-39 131.9 1.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4609) COesterase PF00135.26 T134169_1 - 8.1e-83 278.9 0.1 9.6e-82 275.4 0.1 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 T134169_1 - 0.00016 21.5 0.8 0.00044 20.0 0.8 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.26 T134169_2 - 1.9e-13 50.0 0.2 4.1e-07 29.2 0.2 2.7 2 1 0 2 2 2 2 Carboxylesterase family DUF4200 PF13863.4 T084463_2 - 3.1e-19 69.4 13.1 3.3e-10 40.3 6.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4200) TMF_DNA_bd PF12329.6 T084463_2 - 2.2 8.2 10.7 0.14 12.1 2.7 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1981 PF09324.8 T312322_1 - 1.5e-11 43.9 1.1 5.8e-11 42.0 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) DCB PF16213.3 T312322_1 - 3.7e-06 26.6 2.9 3.7e-06 26.6 2.9 2.7 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.5 T312322_1 - 0.0027 17.6 1.7 0.0027 17.6 1.7 2.9 3 1 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal SWIRM-assoc_1 PF16495.3 T312322_1 - 0.053 13.5 1.4 0.11 12.4 1.4 1.5 1 0 0 1 1 1 0 SWIRM-associated region 1 EGF PF00008.25 T027353_1 - 1.5e-25 89.0 54.6 7.1e-07 29.3 9.4 5.6 4 1 0 4 4 4 4 EGF-like domain Laminin_G_2 PF02210.22 T027353_1 - 3.7e-18 66.2 0.0 5.3e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 T027353_1 - 2e-09 37.6 0.0 3.1e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.5 T027353_1 - 3.1e-08 33.9 47.8 0.0011 19.4 9.4 5.9 5 0 0 5 5 5 4 Human growth factor-like EGF EGF_CA PF07645.13 T027353_1 - 0.00014 21.8 52.2 0.00063 19.8 7.8 5.6 5 0 0 5 5 5 3 Calcium-binding EGF domain EGF_2 PF07974.11 T027353_1 - 0.00016 21.8 68.3 0.024 14.9 2.5 6.4 6 1 0 6 6 6 4 EGF-like domain SH3_6 PF12913.5 T027353_1 - 0.019 14.4 0.1 0.055 12.9 0.1 1.7 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) EGF_3 PF12947.5 T027353_1 - 2.1 8.5 44.4 2 8.5 1.9 4.9 4 0 0 4 4 4 0 EGF domain RnaseA PF00074.18 T100414_2 - 4.9e-20 72.1 4.9 9.4e-20 71.2 4.9 1.3 1 0 0 1 1 1 1 Pancreatic ribonuclease DUF1917 PF08939.8 T061447_2 - 6.1e-15 55.7 0.0 9.3e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1917) zf-H2C2_2 PF13465.4 T069292_2 - 7e-36 120.9 70.0 1.3e-09 37.9 2.7 10.8 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2 PF00096.24 T069292_2 - 8.1e-36 120.4 80.7 3.5e-06 27.0 3.2 9.1 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T069292_2 - 1.6e-20 71.9 72.7 0.0028 18.2 2.1 8.8 8 0 0 8 8 8 8 C2H2-type zinc finger KRAB PF01352.25 T069292_2 - 6.3e-13 48.0 0.1 1.4e-12 47.0 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T069292_2 - 0.00017 21.3 1.7 0.00017 21.3 1.7 8.4 9 0 0 9 9 9 4 C2H2-type zinc finger zf-met PF12874.5 T069292_2 - 0.0011 19.2 51.3 0.42 10.9 0.8 7.3 7 0 0 7 7 7 5 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 T069292_2 - 0.0019 18.2 36.1 0.14 12.2 1.0 4.9 4 1 0 4 4 4 4 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T069292_2 - 0.023 14.9 38.7 0.32 11.2 0.1 8.3 8 0 0 8 8 8 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T069292_2 - 2.4 8.8 23.3 9.2 7.0 1.1 4.6 2 1 2 4 4 4 0 zinc-ribbon family SCAN PF02023.15 T069292_3 - 4.7e-41 138.4 2.8 8.1e-41 137.6 2.8 1.4 1 0 0 1 1 1 1 SCAN domain zf-HIT PF04438.14 T146068_3 - 1.6e-08 34.1 11.1 1.6e-08 34.1 11.1 1.6 1 1 0 1 1 1 1 HIT zinc finger BORG_CEP PF14957.4 T061086_1 - 1.9e-20 74.0 2.6 7.8e-20 72.0 2.6 2.0 1 1 0 1 1 1 1 Cdc42 effector PBD PF00786.26 T061086_1 - 2.4e-08 34.1 0.0 4.1e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain DNA_pol_E_B PF04042.14 T061086_2 - 8.9e-45 152.5 0.2 1.3e-44 152.0 0.2 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.8 T061086_2 - 8.7e-10 38.8 0.0 1.5e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal EF-hand_1 PF00036.30 T056700_3 - 2.3e-18 64.2 17.0 0.00054 19.2 0.1 6.4 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.4 T056700_3 - 4.3e-17 60.4 12.4 0.0021 17.8 0.0 6.4 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.4 T056700_3 - 8.9e-14 51.6 22.0 0.0013 19.1 1.5 4.5 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.4 T056700_3 - 4.4e-10 38.5 23.4 0.0071 15.7 0.1 6.2 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.4 T056700_3 - 4.8e-05 22.9 13.1 0.6 9.8 0.0 5.5 5 0 0 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 T056700_3 - 0.81 9.9 13.5 5.3 7.3 1.6 3.2 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Peptidase_M14 PF00246.22 T333238_1 - 3.6e-11 43.3 0.1 4.6e-11 42.9 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Peptidase_M14 PF00246.22 T333238_3 - 9.8e-16 58.3 0.0 1.6e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase MBT PF02820.16 T036786_2 - 4.4e-21 74.9 1.2 6.3e-21 74.4 0.1 1.9 2 0 0 2 2 2 1 mbt repeat MBT PF02820.16 T036786_3 - 1.5e-46 156.5 1.5 3.6e-21 75.2 0.1 3.5 3 0 0 3 3 3 3 mbt repeat SLED PF12140.6 T036786_3 - 3.8e-37 127.1 0.2 6.8e-37 126.3 0.2 1.4 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.28 T036786_3 - 1.3e-07 31.8 0.0 2.4e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 T036786_3 - 8.1e-05 22.4 0.0 0.00025 20.8 0.0 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.15 T036786_3 - 0.00071 19.5 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ste50p-SAM PF09235.8 T036786_3 - 0.03 14.4 0.1 0.055 13.6 0.1 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Toxin_18 PF08087.9 T181081_2 - 2.5 8.1 7.4 0.46 10.4 3.0 2.2 2 0 0 2 2 2 0 Conotoxin O-superfamily adh_short PF00106.23 T181081_3 - 1.6e-34 119.0 0.0 4.9e-34 117.4 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 T181081_3 - 5.1e-24 85.0 0.0 1.1e-23 83.9 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 T181081_3 - 6.3e-06 26.1 0.1 1e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 T181081_3 - 0.00018 20.9 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.16 T181081_3 - 0.0065 16.6 0.2 0.01 15.9 0.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain LRR_8 PF13855.4 T362490_3 - 5.6e-44 147.6 24.5 2.3e-15 56.0 1.1 6.7 5 1 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 T362490_3 - 1.6e-21 75.8 34.2 2.4e-05 24.4 0.8 8.7 6 1 3 9 9 9 7 Leucine Rich repeats (2 copies) VWC PF00093.16 T362490_3 - 1.3e-10 41.3 14.6 2.7e-10 40.3 14.6 1.6 1 0 0 1 1 1 1 von Willebrand factor type C domain LRR_5 PF13306.4 T362490_3 - 1.2e-07 31.7 6.4 0.00021 21.1 0.1 3.4 2 1 0 3 3 3 2 Leucine rich repeats (6 copies) FNIP PF05725.10 T362490_3 - 0.001 19.0 5.9 21 5.3 0.2 5.4 4 1 2 6 6 6 0 FNIP Repeat LRR_1 PF00560.31 T362490_3 - 0.0018 18.3 32.0 3.6 8.3 0.1 10.7 9 2 1 10 10 10 2 Leucine Rich Repeat Amnionless PF14828.4 T362490_3 - 0.0094 14.7 7.0 0.015 14.1 7.0 1.2 1 0 0 1 1 1 1 Amnionless LRR_9 PF14580.4 T362490_3 - 0.026 13.9 19.3 3.6 6.9 0.8 4.4 1 1 3 5 5 5 0 Leucine-rich repeat LRR_6 PF13516.4 T362490_3 - 0.09 12.8 25.2 0.26 11.3 0.2 8.7 10 0 0 10 10 10 0 Leucine Rich repeat SERTA PF06031.11 T362490_3 - 1.1 8.8 4.6 23 4.6 1.1 2.7 2 0 0 2 2 2 0 SERTA motif BUD22 PF09073.8 T362490_3 - 1.2 8.3 13.3 1.8 7.7 13.3 1.1 1 0 0 1 1 1 0 BUD22 SAPS PF04499.13 T362490_3 - 1.5 7.4 5.5 2.7 6.5 5.5 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Spore_coat_CotO PF14153.4 T362490_3 - 4.8 6.9 11.6 9.7 5.9 11.6 1.4 1 0 0 1 1 1 0 Spore coat protein CotO bZIP_Maf PF03131.15 T079695_2 - 5e-16 58.9 5.0 7.9e-16 58.2 5.0 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.19 T079695_2 - 6e-07 29.3 10.0 9.8e-07 28.6 10.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 T079695_2 - 0.0039 17.1 12.0 0.0075 16.2 12.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper Peptidase_Mx PF15887.3 T079695_2 - 0.17 11.1 0.1 0.28 10.4 0.1 1.2 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase Smg4_UPF3 PF03467.13 T379379_2 - 8.3e-54 182.1 5.1 8.3e-54 182.1 5.1 3.3 2 1 1 3 3 3 1 Smg-4/UPF3 family Pkinase PF00069.23 T232275_1 - 2.8e-46 157.9 0.1 4.2e-46 157.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T232275_1 - 4e-46 157.3 0.1 1.9e-45 155.1 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase PP1_inhibitor PF05361.10 T232275_1 - 1.2e-24 86.8 0.4 2.2e-24 85.9 0.4 1.3 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor PDZ PF00595.22 T232275_1 - 3.6e-16 59.1 0.0 6.2e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LIM PF00412.20 T232275_1 - 8.9e-16 57.7 12.5 3.1e-08 33.6 5.4 2.6 2 0 0 2 2 2 2 LIM domain Kdo PF06293.12 T232275_1 - 2.6e-05 23.5 0.1 4.4e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 T232275_1 - 0.023 14.5 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PDZ_2 PF13180.4 T232275_1 - 0.073 13.3 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 PDZ domain zf-RRN7 PF11781.6 T232275_1 - 5.7 6.6 6.2 0.93 9.1 0.7 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 LIM PF00412.20 T232275_3 - 0.016 15.3 2.5 0.051 13.7 2.5 1.9 1 0 0 1 1 1 0 LIM domain IFT46_B_C PF12317.6 T068354_2 - 3.3e-103 343.9 1.1 4.2e-103 343.5 1.1 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal CNDH2_C PF16858.3 T068354_2 - 0.017 14.9 2.1 0.027 14.3 2.1 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term FAM176 PF14851.4 T068354_2 - 0.31 10.6 3.6 0.75 9.3 3.6 1.5 1 0 0 1 1 1 0 FAM176 family TLP-20 PF06088.9 T068354_2 - 0.33 10.7 1.5 0.62 9.8 1.5 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Astro_capsid_p PF12226.6 T068354_2 - 5.4 5.9 6.5 8.5 5.3 6.5 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF4638 PF15472.4 T131973_2 - 2.8e-123 410.9 13.4 4e-123 410.4 13.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4638) Pkinase PF00069.23 T028890_3 - 5.5e-68 229.0 0.0 7.3e-68 228.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T028890_3 - 2.5e-31 108.8 0.0 3.5e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T028890_3 - 3.6e-05 23.1 0.0 5.8e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.9 T028890_3 - 0.25 10.2 0.1 0.37 9.7 0.1 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Ion_trans PF00520.29 T243698_1 - 1.4e-252 833.2 96.2 4.4e-71 238.8 15.2 4.6 5 0 0 5 5 5 4 Ion transport protein CAC1F_C PF16885.3 T243698_1 - 2.3e-69 234.7 3.5 2.3e-69 234.7 3.5 2.0 2 0 0 2 2 2 1 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 T243698_1 - 1.1e-35 121.1 0.0 2.8e-35 119.8 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 T243698_1 - 2.3e-30 104.5 0.1 4.6e-30 103.6 0.1 1.5 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 T243698_1 - 2.1e-11 43.0 6.5 2.1e-11 43.0 6.5 8.3 7 3 1 8 8 8 3 Polycystin cation channel DUF1510 PF07423.9 T243698_1 - 9.8 5.4 9.8 0.16 11.3 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1510) 3HCDH_N PF02737.16 T186420_1 - 1.6e-54 184.4 0.7 2.8e-54 183.6 0.7 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.18 T186420_1 - 3.9e-37 127.8 0.0 6.2e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.20 T186420_1 - 6.9e-35 119.4 0.0 3.5e-27 94.7 0.0 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.3 T186420_1 - 2.7e-24 86.2 0.0 5.7e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase WD40 PF00400.30 T284655_1 - 3.3e-06 27.6 0.0 0.13 13.1 0.0 3.2 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40 PF00400.30 T284655_2 - 2.7e-06 27.9 2.4 0.0011 19.7 0.0 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat DNA_pol_A_exo1 PF01612.18 T370105_3 - 2.6e-21 76.0 0.0 4.1e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease Mut7-C PF01927.14 T370105_3 - 1.7e-20 73.5 6.3 1.7e-15 57.3 1.6 2.3 2 0 0 2 2 2 2 Mut7-C RNAse domain UPF0183 PF03676.12 T134220_2 - 7.8e-77 259.0 2.5 3e-49 168.2 1.0 2.1 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0183) Nramp PF01566.16 T078514_3 - 8.2e-119 396.6 13.6 1.2e-118 396.1 13.6 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Glyco_hydro_31 PF01055.24 T334546_2 - 9.8e-06 24.9 0.0 1.3e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Glyco_hydro_31 PF01055.24 T334546_3 - 2.9e-281 932.8 8.3 2.6e-155 517.8 1.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.3 T334546_3 - 1.3e-64 215.4 2.8 9.3e-34 116.0 0.6 2.8 3 0 0 3 3 3 2 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.16 T334546_3 - 1.5e-20 72.6 18.0 4.7e-12 45.5 8.6 2.5 2 0 0 2 2 2 2 Trefoil (P-type) domain Gal_mutarotas_2 PF13802.4 T334546_3 - 4.7e-11 42.7 5.0 0.00012 22.2 0.3 3.0 2 0 0 2 2 2 2 Galactose mutarotase-like DUF5110 PF17137.2 T334546_3 - 0.0014 18.7 0.0 0.0035 17.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) TFIIS_M PF07500.12 T305948_3 - 7.1e-32 110.0 3.2 1.9e-31 108.6 3.2 1.8 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.11 T305948_3 - 3.6e-29 101.5 0.0 9.8e-29 100.1 0.0 1.8 1 0 0 1 1 1 1 SPOC domain PHD PF00628.27 T305948_3 - 2.7e-09 36.6 10.3 9.7e-09 34.9 10.3 2.1 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H_2 PF13832.4 T305948_3 - 0.045 13.8 3.7 0.17 11.9 3.7 2.0 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 T305948_3 - 5.2 7.2 8.9 8.3 6.6 5.4 2.9 2 0 0 2 2 2 0 PHD-like zinc-binding domain OppC_N PF12911.5 T126380_2 - 0.14 12.1 0.1 0.3 11.0 0.1 1.5 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C AMP-binding PF00501.26 T128366_2 - 8.8e-12 44.2 0.1 1.5e-11 43.5 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 T128366_2 - 3e-07 31.2 0.0 5.2e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SPRY PF00622.26 T363612_3 - 9.9e-14 51.4 0.0 1.7e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 T363612_3 - 2e-08 33.6 0.2 4.1e-08 32.6 0.2 1.6 1 0 0 1 1 1 1 SPRY-associated domain Pkinase_Tyr PF07714.15 T144352_2 - 5.8e-47 160.0 0.0 7.8e-47 159.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T144352_2 - 7e-37 127.1 0.0 9.8e-37 126.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 T144352_2 - 1.5e-05 24.4 0.0 2.2e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like C1_1 PF00130.20 T144352_2 - 0.011 15.4 14.9 0.031 14.0 14.9 1.8 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RIO1 PF01163.20 T144352_2 - 0.012 15.0 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 RIO1 family zf-RING-like PF08746.9 T144352_2 - 1.1 9.5 14.0 3.2 8.0 14.0 1.8 1 0 0 1 1 1 0 RING-like domain KSR1-SAM PF13543.4 T144352_3 - 5.4e-36 123.5 0.0 9.2e-36 122.7 0.0 1.4 1 0 0 1 1 1 1 SAM like domain present in kinase suppressor RAS 1 Dpy19 PF10034.7 T321489_1 - 7.5e-243 807.4 23.2 1e-242 806.9 23.2 1.2 1 0 0 1 1 1 1 Q-cell neuroblast polarisation PMP22_Claudin PF00822.18 T142158_3 - 6.8e-51 172.3 13.9 1e-50 171.7 13.9 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 T142158_3 - 4.5e-06 26.4 10.6 4.5e-06 26.4 10.6 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction L_HMGIC_fpl PF10242.7 T142158_3 - 0.001 19.2 8.6 0.0021 18.1 8.6 1.5 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DUF4064 PF13273.4 T142158_3 - 0.28 11.4 11.4 0.73 10.1 9.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF4834 PF16118.3 T142158_3 - 5.8 7.8 6.6 45 5.0 1.3 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) Dynamin_M PF01031.18 T367064_1 - 2e-34 119.0 0.6 2e-34 119.0 0.6 1.6 2 0 0 2 2 2 1 Dynamin central region GED PF02212.16 T367064_1 - 2.7e-27 94.6 2.3 4.4e-27 93.9 2.3 1.3 1 0 0 1 1 1 1 Dynamin GTPase effector domain PH PF00169.27 T367064_1 - 7.6e-12 45.5 1.0 1.3e-11 44.8 1.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 T367064_1 - 2 8.8 4.2 2 8.7 2.1 2.1 2 1 0 2 2 2 0 Pleckstrin homology domain Dynamin_M PF01031.18 T367064_3 - 7.7e-70 235.2 0.1 1.1e-69 234.7 0.1 1.1 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.21 T367064_3 - 7e-54 182.2 0.0 1.2e-53 181.5 0.0 1.4 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.21 T367064_3 - 0.008 16.1 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RRM_1 PF00076.20 T173866_1 - 0.00066 19.3 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.22 T173866_2 - 0.014 15.2 0.5 0.037 13.8 0.5 1.8 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH PF00642.22 T173866_3 - 0.18 11.6 5.5 0.079 12.8 2.4 2.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ORMDL PF04061.12 T146956_1 - 3.6e-52 175.6 4.7 6.1e-52 174.9 4.7 1.4 1 0 0 1 1 1 1 ORMDL family Gasdermin PF04598.10 T146956_1 - 4.5e-12 45.6 5.1 6.2e-12 45.1 5.1 1.1 1 0 0 1 1 1 1 Gasdermin family Gasdermin PF04598.10 T146956_2 - 1.2e-20 73.9 0.1 1.6e-20 73.5 0.1 1.1 1 0 0 1 1 1 1 Gasdermin family UCH PF00443.27 T242489_1 - 7.8e-82 274.5 0.1 1.1e-81 274.0 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.4 T242489_1 - 1.6e-30 104.7 0.1 2.8e-30 103.9 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.10 T242489_1 - 2.8e-22 79.0 1.0 5.2e-22 78.1 1.0 1.5 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.4 T242489_1 - 4.1e-19 69.2 0.0 5.1e-12 45.9 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.4 T242489_1 - 0.00021 21.0 0.0 0.0011 18.7 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.6 T242489_1 - 0.0018 17.6 0.0 0.0035 16.7 0.0 1.3 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 CW_binding_1 PF01473.18 T242489_1 - 1.7 9.0 4.3 4.9 7.6 4.3 1.8 1 0 0 1 1 1 0 Putative cell wall binding repeat DUF4712 PF15830.3 T242489_2 - 4.4e-39 134.6 2.2 6.2e-39 134.1 2.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4712) DUF4712 PF15830.3 T242489_3 - 4.3e-65 219.8 0.3 6e-65 219.3 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4712) Requiem_N PF14051.4 T174815_3 - 5.9e-36 122.4 0.2 1e-35 121.6 0.2 1.4 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. PHD PF00628.27 T174815_3 - 5.6e-18 64.4 23.0 4e-09 36.1 4.6 3.4 2 1 1 3 3 3 2 PHD-finger zf-ANAPC11 PF12861.5 T174815_3 - 0.12 12.4 4.4 0.28 11.1 4.4 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger ACAS_N PF16177.3 T155073_1 - 0.15 11.9 0.4 0.31 10.9 0.4 1.5 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus Glyco_transf_18 PF15024.4 T155073_2 - 5.6e-264 876.8 0.0 6.7e-264 876.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 WH2 PF02205.18 T332335_1 - 0.014 15.1 0.0 0.037 13.7 0.0 1.7 1 0 0 1 1 1 0 WH2 motif Reprolysin PF01421.17 T021829_1 - 2e-54 184.4 0.0 3.2e-54 183.7 0.0 1.2 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 T021829_1 - 2.8e-27 95.3 1.6 2.8e-27 95.3 1.6 2.6 2 0 0 2 2 2 1 ADAM cysteine-rich Disintegrin PF00200.21 T021829_1 - 8.6e-21 74.4 24.3 8.6e-21 74.4 24.3 4.4 4 0 0 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.17 T021829_1 - 4.3e-14 52.8 0.0 8.1e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 T021829_1 - 1.4e-13 51.3 0.0 2.3e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T021829_1 - 2e-09 37.9 0.0 3.2e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T021829_1 - 1e-06 28.6 0.0 1.7e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T021829_1 - 6.7e-05 22.5 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like CD20 PF04103.13 T021829_1 - 0.011 15.7 0.2 0.02 14.8 0.2 1.3 1 0 0 1 1 1 0 CD20-like family Peptidase_M10 PF00413.22 T021829_1 - 0.13 12.0 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 Matrixin Ephrin PF00812.15 T021829_2 - 2.1e-36 124.8 0.0 3.5e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 Ephrin CEBP_ZZ PF16366.3 T021829_2 - 0.85 9.8 11.7 2.3 8.4 11.7 1.7 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain DUF1272 PF06906.9 T021829_2 - 3.3 7.7 10.5 12 5.9 10.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) ASH PF15780.3 T240266_2 - 2.3e-13 50.1 0.1 6.6 6.9 0.0 9.4 10 0 0 10 10 10 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.4 T240266_2 - 2.3e-05 24.3 0.1 15 5.7 0.0 5.8 7 0 0 7 7 7 2 Flagellar-associated PapD-like TMEM131_like PF12371.6 T240266_2 - 0.00069 19.6 0.6 1.3 9.0 0.1 5.4 6 0 0 6 6 6 1 Transmembrane protein 131-like DUF1978 PF09321.8 T240266_2 - 0.39 9.9 7.5 0.014 14.6 1.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1978) Vir_act_alpha_C PF10400.7 T240266_2 - 0.42 11.2 4.5 0.25 11.9 1.5 2.1 2 0 0 2 2 2 0 Virulence activator alpha C-term JIP_LZII PF16471.3 T150647_1 - 9e-29 99.3 12.7 9e-29 99.3 12.7 3.2 4 0 0 4 4 4 1 JNK-interacting protein leucine zipper II RILP PF11461.6 T150647_1 - 0.73 9.9 7.4 0.078 13.1 0.4 2.6 2 0 0 2 2 2 0 Rab interacting lysosomal protein CTU2 PF10288.7 T138301_2 - 3.5e-21 75.4 0.0 6.7e-21 74.5 0.0 1.5 1 1 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 Histone PF00125.22 T299471_2 - 4.2e-24 85.3 0.3 6.6e-24 84.7 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 T299471_2 - 1.9e-05 24.7 0.0 3.8e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 T299471_2 - 0.068 13.5 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A FYRC PF05965.12 T068321_2 - 2.4e-21 75.5 0.0 5.4e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 F/Y rich C-terminus SET PF00856.26 T068321_2 - 3.3e-21 76.3 0.7 3.3e-21 76.3 0.7 3.1 3 0 0 3 3 3 1 SET domain PHD PF00628.27 T068321_2 - 5e-16 58.2 74.3 2.8e-08 33.4 11.9 5.3 3 1 1 4 4 4 3 PHD-finger C2-set_2 PF08205.10 T068321_2 - 7.7e-16 57.8 0.2 8.3e-14 51.3 0.0 2.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain FYRN PF05964.12 T068321_2 - 9.3e-16 57.3 0.1 2.1e-15 56.2 0.1 1.7 1 0 0 1 1 1 1 F/Y-rich N-terminus zf-CXXC PF02008.18 T068321_2 - 7.8e-13 48.1 23.6 7.8e-13 48.1 23.6 5.0 4 1 1 5 5 5 1 CXXC zinc finger domain PHD_2 PF13831.4 T068321_2 - 0.0011 18.3 22.8 0.046 13.1 2.5 4.1 3 0 0 3 3 3 2 PHD-finger Bromodomain PF00439.23 T068321_2 - 0.0098 15.8 0.0 0.027 14.4 0.0 1.6 1 0 0 1 1 1 1 Bromodomain TPR_11 PF13414.4 T068321_2 - 0.053 13.1 0.1 0.1 12.1 0.1 1.5 1 0 0 1 1 1 0 TPR repeat DUF3915 PF13054.4 T068321_2 - 4 7.3 5.6 11 5.9 5.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Arf PF00025.19 T283364_3 - 1.5e-70 236.1 0.0 2.6e-70 235.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 T283364_3 - 1.6e-12 47.5 0.2 6.7e-12 45.6 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 T283364_3 - 4.4e-11 42.5 0.0 7.1e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 T283364_3 - 4.1e-10 39.2 0.0 6.7e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 T283364_3 - 1.1e-08 34.5 0.1 6.4e-07 28.7 0.1 2.1 1 1 1 2 2 2 1 G-protein alpha subunit zf-B_box PF00643.22 T283364_3 - 2.3e-06 27.5 5.9 2.3e-06 27.5 5.9 3.7 3 0 0 3 3 3 2 B-box zinc finger zf-RING_UBOX PF13445.4 T283364_3 - 2.5e-06 27.3 5.4 1.2e-05 25.1 5.4 2.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 T283364_3 - 7.8e-06 25.6 1.9 7.8e-06 25.6 1.9 3.7 3 1 0 3 3 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 T283364_3 - 0.00011 22.2 3.4 0.00011 22.2 3.4 3.9 3 0 0 3 3 2 1 Ring finger domain MMR_HSR1 PF01926.21 T283364_3 - 0.0038 17.2 0.0 0.0071 16.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase zf-C3HC4 PF00097.23 T283364_3 - 0.0064 16.2 1.7 0.0064 16.2 1.7 3.0 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T283364_3 - 5.3 6.8 14.0 0.036 13.8 3.7 2.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ZU5 PF00791.18 T269885_2 - 1.3e-34 118.3 0.5 1.5e-26 92.4 0.0 2.5 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 T269885_2 - 4.5e-22 77.9 0.9 8.1e-22 77.1 0.9 1.4 1 0 0 1 1 1 1 Death domain Pkinase_Tyr PF07714.15 T146818_3 - 4.6e-86 288.2 0.0 6.4e-86 287.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 T146818_3 - 3.1e-54 181.7 0.0 2.7e-32 111.1 0.0 2.3 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 T146818_3 - 1.3e-42 144.5 80.1 4.2e-41 139.7 26.2 4.1 3 1 1 4 4 4 2 Growth factor receptor domain IV Pkinase PF00069.23 T146818_3 - 1.3e-36 126.2 0.0 1.9e-36 125.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 T146818_3 - 3.4e-28 98.3 82.8 7.1e-25 87.5 37.5 4.2 2 1 0 2 2 2 2 Furin-like cysteine rich region APH PF01636.21 T146818_3 - 0.017 14.9 0.1 0.033 14.0 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family OCC1 PF15506.4 T085595_3 - 7.1e-19 67.6 12.7 7.1e-19 67.6 12.7 2.6 2 1 0 2 2 2 1 OCC1 family Axin_b-cat_bind PF08833.8 T226101_1 - 0.68 10.0 2.5 1.4 9.0 0.8 2.5 2 0 0 2 2 2 0 Axin beta-catenin binding domain Ets PF00178.20 T226101_3 - 5.9e-36 122.7 1.2 5.9e-36 122.7 1.2 1.9 2 0 0 2 2 2 1 Ets-domain SAM_PNT PF02198.14 T226101_3 - 3.1e-32 110.3 1.3 6.5e-32 109.2 1.3 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Abi_HHR PF07815.12 T038738_2 - 1.2e-35 121.3 0.5 1.9e-35 120.7 0.5 1.3 1 0 0 1 1 1 1 Abl-interactor HHR SH3_1 PF00018.26 T038738_2 - 2.3e-16 59.0 0.4 7.6e-16 57.3 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 T038738_2 - 1.7e-14 53.3 0.1 3.4e-14 52.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T038738_2 - 1.5e-10 40.4 0.1 2.5e-10 39.7 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain FH2 PF02181.21 T113922_1 - 3e-42 145.0 0.3 4.2e-42 144.5 0.3 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain FH2 PF02181.21 T113922_3 - 1.5e-40 139.3 4.2 2.2e-40 138.8 4.2 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Beta-lactamase PF00144.22 T117838_1 - 2.1e-39 135.6 0.0 6.8e-29 101.0 0.0 2.2 2 0 0 2 2 2 2 Beta-lactamase EF-hand_7 PF13499.4 T104240_3 - 1.1e-05 25.7 4.4 0.14 12.5 0.1 4.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.4 T104240_3 - 0.00016 21.3 2.4 0.015 15.1 0.1 4.0 3 0 0 3 3 3 1 EF-hand domain TSC22 PF01166.16 T104240_3 - 0.0012 18.9 7.2 0.0012 18.9 7.2 14.2 15 1 1 16 16 16 2 TSC-22/dip/bun family EF-hand_1 PF00036.30 T104240_3 - 0.0016 17.8 0.4 0.28 10.7 0.0 3.8 3 0 0 3 3 3 1 EF hand MORN PF02493.18 T241745_1 - 6.4e-10 38.2 17.3 0.0033 17.1 0.2 4.8 4 0 0 4 4 4 4 MORN repeat MORN PF02493.18 T241745_2 - 0.03 14.1 4.7 5.3 7.0 0.1 4.5 4 0 0 4 4 4 0 MORN repeat VPS9 PF02204.16 T241745_3 - 8.6e-14 51.5 0.0 2.6e-08 33.9 0.0 2.2 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain CENP-F_leu_zip PF10473.7 T260422_1 - 0.21 11.5 12.5 0.12 12.2 8.4 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF972 PF06156.11 T260422_1 - 0.22 12.0 11.3 1.1 9.7 2.2 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF972) BRE1 PF08647.9 T260422_1 - 0.67 9.9 3.9 0.7 9.9 2.7 1.6 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase KIAA1430 PF13879.4 T260422_1 - 1.1 9.9 4.1 3.2 8.4 4.1 1.8 1 0 0 1 1 1 0 KIAA1430 homologue ATG16 PF08614.9 T260422_1 - 2 8.4 8.5 1.6 8.7 5.7 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) bZIP_1 PF00170.19 T260422_1 - 2.4 8.2 9.8 9.9 6.2 1.1 3.5 3 0 0 3 3 3 0 bZIP transcription factor APG6 PF04111.10 T260422_1 - 4.4 6.5 9.4 11 5.1 9.3 1.6 1 1 0 1 1 1 0 Autophagy protein Apg6 ADIP PF11559.6 T260422_1 - 5.5 6.9 9.6 17 5.3 9.6 1.9 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4200 PF13863.4 T260422_1 - 6.7 7.0 7.1 2.1 8.6 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) UPF0231 PF06062.9 T260422_2 - 0.29 11.3 0.5 0.48 10.6 0.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) DUF745 PF05335.11 T260422_2 - 1.1 8.8 4.2 1.7 8.2 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) OmpH PF03938.12 T260422_3 - 0.49 10.3 3.1 0.77 9.6 3.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Jnk-SapK_ap_N PF09744.7 T260422_3 - 2.8 8.0 6.8 4.4 7.4 6.8 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Lectin_C PF00059.19 T044830_3 - 1.2e-22 80.5 0.0 1.9e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 T044830_3 - 1.2e-09 37.7 32.9 1.8e-05 24.2 14.2 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) C2 PF00168.28 T181177_2 - 6.5e-49 164.4 0.0 1.3e-23 83.1 0.0 2.3 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.4 T181177_2 - 0.064 12.7 0.0 0.79 9.1 0.0 2.1 2 0 0 2 2 2 0 CEP76 C2 domain Y_phosphatase PF00102.25 T181177_3 - 6.5e-77 258.1 0.0 1.3e-76 257.1 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.19 T181177_3 - 9.7e-55 182.8 41.9 1.6e-08 34.6 4.3 7.9 8 0 0 8 8 8 7 Fibronectin type III domain DUF2369 PF10179.7 T181177_3 - 3.3e-12 46.6 2.9 3 8.2 0.0 7.4 7 0 0 7 7 7 3 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.3 T181177_3 - 2.3e-08 34.4 47.1 0.3 11.6 3.6 8.1 5 2 0 6 6 6 5 Purple acid Phosphatase, N-terminal domain SusE PF14292.4 T181177_3 - 2e-06 28.0 22.7 1.9 8.8 0.1 7.1 7 0 0 7 7 7 3 SusE outer membrane protein CBM_4_9 PF02018.15 T181177_3 - 0.001 19.2 19.5 0.57 10.3 0.3 6.5 5 2 1 7 7 7 2 Carbohydrate binding domain Y_phosphatase3 PF13350.4 T181177_3 - 0.0082 16.0 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 T181177_3 - 0.027 14.1 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain EphA2_TM PF14575.4 T181177_3 - 0.051 14.2 0.4 0.14 12.9 0.0 1.9 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.18 T181177_3 - 0.051 13.4 0.5 0.11 12.3 0.5 1.5 1 0 0 1 1 1 0 Syndecan domain Lipoprotein_21 PF14041.4 T181177_3 - 0.43 10.6 6.5 14 5.8 0.2 4.0 4 0 0 4 4 4 0 LppP/LprE lipoprotein DUF2207 PF09972.7 T181177_3 - 1.7 7.2 6.3 16 4.0 0.0 3.4 4 0 0 4 4 4 0 Predicted membrane protein (DUF2207) DUF4945 PF16303.3 T181177_3 - 2.4 8.0 8.8 89 2.9 0.1 5.3 6 0 0 6 6 6 0 Domain of unknown function (DUF4945) Amidohydro_2 PF04909.12 T199863_3 - 1.1e-68 232.0 0.0 1.4e-68 231.7 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase Auts2 PF15336.4 T326039_2 - 1.7e-107 358.4 15.2 1.7e-107 358.4 15.2 4.3 4 1 1 5 5 5 1 Autism susceptibility gene 2 protein Homeobox_KN PF05920.9 T217223_3 - 2.4e-16 59.2 0.2 5.2e-16 58.1 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 T217223_3 - 2.4e-05 23.9 0.2 4.4e-05 23.1 0.2 1.4 1 0 0 1 1 1 1 Homeobox domain zf-C2H2 PF00096.24 T254284_1 - 3.8e-47 156.1 77.7 8.9e-07 28.9 1.4 11.0 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T254284_1 - 1.5e-31 107.3 70.6 6e-08 32.7 1.2 11.7 11 0 0 11 11 11 6 Zinc-finger double domain zf-C2H2_4 PF13894.4 T254284_1 - 1e-29 100.5 75.9 0.0013 19.3 0.7 11.5 11 0 0 11 11 10 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T254284_1 - 8.6e-11 41.4 63.1 0.00022 21.0 0.2 10.1 10 0 0 10 10 10 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T254284_1 - 4.9e-08 32.9 58.3 0.0037 17.4 0.8 11.3 11 0 0 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 T254284_1 - 7.3e-05 22.3 2.4 7.3e-05 22.3 2.4 8.4 9 1 0 9 9 8 5 C2H2-type zinc-finger domain zf-BED PF02892.13 T254284_1 - 0.0012 18.8 0.7 0.0012 18.8 0.7 8.0 4 3 5 9 9 9 3 BED zinc finger zf-C2H2_8 PF15909.3 T254284_1 - 0.033 14.4 40.0 0.26 11.5 8.1 5.5 2 1 3 5 5 5 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.3 T254284_1 - 0.084 12.5 53.9 0.085 12.5 0.8 8.4 10 0 0 10 10 8 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T254284_1 - 0.14 12.1 43.3 0.015 15.3 1.6 7.8 7 1 0 7 7 7 0 Zinc ribbon domain GAGA PF09237.9 T254284_1 - 0.15 11.7 19.2 4.2 7.1 0.1 5.5 3 1 2 5 5 5 0 GAGA factor PyrI_C PF02748.13 T254284_1 - 0.57 10.0 0.0 0.57 10.0 0.0 6.9 6 1 1 7 7 7 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-met PF12874.5 T254284_1 - 9.7 6.6 53.8 0.6 10.4 0.3 9.8 10 0 0 10 10 10 0 Zinc-finger of C2H2 type GST_N PF02798.18 T230837_1 - 0.0031 17.7 0.0 0.0053 16.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.4 T230837_1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 T230837_3 - 0.00046 19.9 0.1 0.00085 19.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 T230837_3 - 0.0025 17.8 0.0 0.0043 17.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain V-set PF07686.15 T024545_3 - 2.4e-21 75.8 0.0 3.7e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 T024545_3 - 0.00014 21.8 0.1 0.00037 20.5 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 T024545_3 - 0.012 16.1 0.1 0.066 13.7 0.1 2.2 2 0 0 2 2 2 0 Immunoglobulin domain Adeno_E3_CR2 PF02439.13 T024545_3 - 0.034 13.8 0.5 0.08 12.6 0.5 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TUDOR PF00567.22 T320022_3 - 8.1e-24 83.8 0.0 2.3e-23 82.4 0.0 1.9 1 0 0 1 1 1 1 Tudor domain Pkinase PF00069.23 T320022_3 - 6.7e-18 64.8 0.0 2.2e-17 63.1 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T320022_3 - 5e-10 39.0 0.0 1.2e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Agenet PF05641.10 T320022_3 - 0.0024 18.2 0.1 0.0071 16.7 0.1 1.8 1 0 0 1 1 1 1 Agenet domain zf-H2C2_2 PF13465.4 T182328_1 - 5e-86 279.5 89.8 6.9e-09 35.6 2.1 14.5 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 T182328_1 - 1.9e-71 232.6 88.0 1.8e-07 31.1 1.3 13.3 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T182328_1 - 5.8e-36 119.9 87.5 0.0054 17.3 1.5 13.4 13 0 0 13 13 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T182328_1 - 1.2e-21 76.0 71.1 0.02 14.7 0.2 12.9 12 0 0 12 12 12 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T182328_1 - 8.9e-15 54.4 58.9 0.0059 16.6 3.5 8.4 3 3 7 10 10 10 10 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T182328_1 - 7.7e-11 41.9 54.9 0.099 12.8 0.1 13.7 14 0 0 14 14 14 4 Zinc-finger double-stranded RNA-binding DZR PF12773.5 T182328_1 - 5.4e-06 26.2 50.2 1.6e+04 -27.0 50.2 7.0 1 1 0 1 1 0 0 Double zinc ribbon XPA_N PF01286.16 T182328_1 - 2.5e-05 24.1 57.3 0.65 9.9 0.1 12.2 13 0 0 13 13 13 4 XPA protein N-terminal zinc_ribbon_15 PF17032.3 T182328_1 - 4.4e-05 24.0 43.2 1.3 9.7 0.9 6.6 1 1 5 6 6 6 5 zinc-ribbon family zf-C2H2_11 PF16622.3 T182328_1 - 0.03 13.9 48.4 1.6 8.5 1.8 10.7 11 0 0 11 11 11 0 zinc-finger C2H2-type zf-C2HC_2 PF13913.4 T182328_1 - 0.055 13.3 0.3 0.055 13.3 0.3 8.9 9 0 0 9 9 9 0 zinc-finger of a C2HC-type HypA PF01155.17 T182328_1 - 0.078 12.9 41.0 2.1 8.3 5.7 6.7 1 1 4 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYDLN_acid PF09538.8 T182328_1 - 0.61 10.7 23.0 16 6.1 0.8 7.9 2 2 5 7 7 7 0 Protein of unknown function (FYDLN_acid) C1_4 PF07975.10 T182328_1 - 5 7.3 51.8 6 7.1 2.2 8.0 1 1 8 10 10 10 0 TFIIH C1-like domain YhfH PF14149.4 T182328_1 - 6.2 6.8 49.6 15 5.5 0.2 11.4 11 0 0 11 11 11 0 YhfH-like protein NIF3 PF01784.16 T205719_2 - 1.7e-78 263.5 0.0 2.6e-78 262.9 0.0 1.2 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) ApoL PF05461.9 T232948_2 - 1.4e-132 441.7 5.2 1.9e-132 441.3 5.2 1.1 1 0 0 1 1 1 1 Apolipoprotein L SseC PF04888.10 T232948_2 - 0.029 13.8 0.3 0.051 12.9 0.3 1.4 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF3150 PF11348.6 T232948_2 - 0.08 12.0 0.3 0.16 11.0 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3150) TBCA PF02970.14 T232948_2 - 1.3 9.3 5.7 0.31 11.3 1.5 2.0 2 0 0 2 2 2 0 Tubulin binding cofactor A CBFD_NFYB_HMF PF00808.21 T365043_2 - 1.9e-12 47.2 0.1 3.3e-12 46.4 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.4 T365043_2 - 0.0073 16.3 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.22 T365043_2 - 0.011 16.0 0.0 0.011 16.0 0.0 2.2 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Afi1 PF07792.10 T365043_2 - 0.041 14.2 5.7 0.079 13.3 5.7 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking BUD22 PF09073.8 T365043_2 - 0.13 11.4 16.0 0.19 10.9 16.0 1.1 1 0 0 1 1 1 0 BUD22 DUF4746 PF15928.3 T365043_2 - 0.32 10.2 11.1 0.45 9.8 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Mtc1 PF10310.7 T365043_2 - 0.73 8.6 14.2 1 8.1 14.2 1.1 1 0 0 1 1 1 0 Maintenance of telomere capping protein 1 DDHD PF02862.15 T365043_2 - 0.98 9.4 4.0 1.3 8.9 4.0 1.1 1 0 0 1 1 1 0 DDHD domain Vfa1 PF08432.8 T365043_2 - 3.5 7.8 16.8 5.2 7.2 16.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Pox_Ag35 PF03286.12 T365043_2 - 5.2 6.7 15.4 7.7 6.1 15.4 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF1510 PF07423.9 T365043_2 - 9.5 5.5 19.2 14 4.9 19.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) NPIP PF06409.9 T128862_3 - 1e-12 47.8 0.3 1.4e-12 47.3 0.3 1.2 1 0 0 1 1 1 1 Nuclear pore complex interacting protein (NPIP) Amino_oxidase PF01593.22 T373683_2 - 4.8e-70 236.9 0.0 6.2e-70 236.6 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 T373683_2 - 4.4e-07 29.9 0.0 4.4e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Myb_DNA-bind_7 PF15963.3 T125051_1 - 0.034 13.9 0.1 0.065 13.0 0.1 1.4 1 0 0 1 1 1 0 Myb DNA-binding like Myb_DNA-binding PF00249.29 T125051_1 - 0.12 12.4 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Jnk-SapK_ap_N PF09744.7 T125051_2 - 5.6e-56 189.0 23.9 5.6e-56 189.0 23.9 2.6 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 JIP_LZII PF16471.3 T125051_2 - 4.5e-28 97.1 9.3 4.5e-28 97.1 9.3 2.8 3 1 0 3 3 3 1 JNK-interacting protein leucine zipper II JUPITER PF17054.3 T125051_2 - 1.8e-07 30.9 0.4 0.00024 20.6 0.1 2.6 2 0 0 2 2 2 2 Microtubule-Associated protein Jupiter Rootletin PF15035.4 T125051_2 - 0.0013 18.7 1.7 0.0013 18.7 1.7 2.8 2 1 1 3 3 3 1 Ciliary rootlet component, centrosome cohesion Atg14 PF10186.7 T125051_2 - 0.095 11.6 25.8 0.09 11.7 10.5 2.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ERM PF00769.17 T125051_2 - 1.5 8.5 28.5 2.4 7.8 8.3 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Methyltransf_PK PF05891.10 T024882_1 - 8.3e-71 237.8 0.0 1.1e-70 237.4 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.4 T024882_1 - 5.5e-07 30.1 0.0 9e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 T024882_1 - 4.9e-05 23.8 0.0 0.0001 22.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 T024882_1 - 5e-05 23.7 0.0 8.5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.16 T024882_1 - 0.018 14.1 0.0 0.027 13.5 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase DUF3512 PF12024.6 T277279_2 - 3.4e-84 281.9 0.2 3.4e-84 281.9 0.2 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3512) Bromodomain PF00439.23 T277279_2 - 1.6e-22 79.2 0.0 6.1e-22 77.4 0.1 1.8 2 0 0 2 2 2 1 Bromodomain TFIIF_alpha PF05793.10 T277279_2 - 0.23 9.8 15.5 0.34 9.3 15.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SR-25 PF10500.7 T277279_2 - 0.33 10.4 15.7 0.68 9.4 15.7 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med19 PF10278.7 T277279_2 - 0.55 10.0 19.8 1.1 9.0 19.8 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF1908 PF08926.9 T283492_3 - 5.4e-131 435.7 0.8 5.4e-131 435.7 0.8 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1908) Pkinase PF00069.23 T283492_3 - 1.6e-60 204.6 0.0 2.5e-60 203.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T283492_3 - 4.3e-26 91.6 0.0 7.3e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.22 T283492_3 - 5.7e-08 32.9 0.0 1.1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T283492_3 - 7.3e-07 29.3 0.0 1.6e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain APH PF01636.21 T283492_3 - 8.4e-05 22.5 0.0 0.086 12.6 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Tricorn_PDZ PF14685.4 T283492_3 - 0.0016 18.2 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 Tricorn protease PDZ domain Kinase-like PF14531.4 T283492_3 - 0.0023 17.2 0.0 0.0041 16.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 T283492_3 - 0.064 12.7 0.1 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Tachystatin_B PF11478.6 T283492_3 - 0.22 11.3 4.0 0.099 12.5 0.2 2.3 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B Ig_2 PF13895.4 T180751_1 - 5.3e-32 109.9 0.0 4.8e-12 45.9 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 T180751_1 - 2.4e-22 79.2 0.0 0.00028 21.3 0.1 4.6 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 T180751_1 - 1.7e-15 56.8 0.0 2.5e-05 24.2 0.0 4.4 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.15 T180751_1 - 0.0027 17.7 1.4 26 4.9 0.0 5.2 4 2 0 5 5 5 1 Immunoglobulin V-set domain zf-B_box PF00643.22 T002134_1 - 1e-07 31.8 6.0 1e-07 31.8 6.0 3.9 4 0 0 4 4 3 1 B-box zinc finger AIP3 PF03915.11 T002134_1 - 5.9e-05 22.2 2.8 5.9e-05 22.2 2.8 1.5 2 0 0 2 2 2 1 Actin interacting protein 3 DUF3583 PF12126.6 T002134_1 - 5.9e-05 22.5 0.4 5.9e-05 22.5 0.4 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF3583) zf-C3HC4 PF00097.23 T002134_1 - 0.00028 20.6 8.3 0.00028 20.6 8.3 3.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T002134_1 - 0.0025 17.6 11.0 0.0025 17.6 11.0 3.5 3 0 0 3 3 3 1 zinc-RING finger domain IL10 PF00726.15 T002134_1 - 0.12 11.7 2.3 0.1 12.0 0.6 1.8 2 0 0 2 2 2 0 Interleukin 10 DUF2321 PF10083.7 T002134_1 - 0.23 11.0 1.7 4.5 6.8 1.6 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) FYVE PF01363.19 T002134_1 - 1.3 9.0 9.4 5.5 7.1 9.4 2.1 1 0 0 1 1 1 0 FYVE zinc finger DUF1664 PF07889.10 T002134_1 - 1.5 8.7 4.0 12 5.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DASH_Spc34 PF08657.8 T002134_1 - 4.3 7.0 6.4 0.43 10.3 0.3 2.0 2 0 0 2 2 2 0 DASH complex subunit Spc34 IBR PF01485.19 T002134_1 - 5.2 7.2 17.1 0.021 14.9 2.8 3.0 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain DUF3704 PF12488.6 T045043_1 - 6.5e-05 22.4 1.6 0.00016 21.1 1.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3704) Dpy-30 PF05186.11 T045043_2 - 4.5e-17 61.3 0.4 2.1e-16 59.2 0.1 2.1 2 0 0 2 2 2 1 Dpy-30 motif E7 PF00527.16 T045043_2 - 1 9.5 5.5 0.63 10.1 3.1 1.8 2 0 0 2 2 2 0 E7 protein, Early protein HlyIII PF03006.18 T251659_1 - 2.4e-31 109.1 16.8 4.5e-31 108.2 16.8 1.5 1 0 0 1 1 1 1 Haemolysin-III related Cation_ATPase_C PF00689.19 T382187_3 - 3.9e-46 156.9 1.7 3.9e-46 156.9 1.7 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus ATP_Ca_trans_C PF12424.6 T382187_3 - 3.3e-22 78.6 2.9 1.2e-10 41.5 1.6 2.8 1 1 1 2 2 2 2 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.4 T382187_3 - 4.1e-18 65.1 0.0 8.2e-18 64.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 T382187_3 - 9.7e-15 55.3 0.5 1.3e-13 51.7 0.5 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.18 T382187_3 - 1.6e-12 47.1 3.9 3.6e-11 42.7 1.1 2.5 2 0 0 2 2 2 2 E1-E2 ATPase Hydrolase_3 PF08282.10 T382187_3 - 9.3e-07 28.7 0.4 0.00017 21.3 0.2 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Adaptin_N PF01602.18 T135775_3 - 9.3e-155 516.0 8.1 1.1e-154 515.7 8.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.18 T135775_3 - 1.4e-33 115.3 5.2 2.2e-33 114.7 5.2 1.3 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.5 T135775_3 - 5.5e-12 45.9 3.6 5.9e-09 36.0 0.3 2.8 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 COE1_DBD PF16422.3 T050923_1 - 8e-148 489.9 1.6 1.1e-147 489.4 1.6 1.2 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.3 T050923_1 - 9.7e-35 117.9 3.0 1.7e-28 98.0 0.4 2.6 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.22 T050923_1 - 1.7e-12 47.1 0.1 3.7e-12 46.0 0.1 1.6 1 0 0 1 1 1 1 IPT/TIG domain RNF111_N PF15303.4 T050923_3 - 0.19 11.3 3.9 0.46 10.1 0.7 2.1 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase Arkadia N-terminus DUF410 PF04190.11 T317053_2 - 7.2e-74 248.7 0.0 9.6e-74 248.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) C2 PF00168.28 T130074_3 - 1.9e-46 156.5 0.0 4.9e-23 81.2 0.0 2.3 2 0 0 2 2 2 2 C2 domain RCC1 PF00415.16 T373134_2 - 1.7e-71 236.5 17.3 2.2e-12 47.2 0.3 8.1 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 T373134_2 - 1.9e-38 129.3 22.9 3.2e-09 36.2 0.0 7.9 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.4 T373134_2 - 1.1e-07 31.5 5.4 0.14 12.0 0.4 4.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.4 T373134_2 - 0.087 13.0 3.0 36 4.7 0.0 3.7 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.4 T373134_2 - 0.088 12.7 3.3 43 4.1 0.0 3.7 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.13 T373134_2 - 0.1 12.5 0.3 31 4.6 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.23 T373134_2 - 5.5 6.5 7.8 3.4 7.2 0.1 3.7 5 0 0 5 5 5 0 Kelch motif Reprolysin PF01421.17 T021831_1 - 1.9e-54 184.5 0.0 3.1e-54 183.8 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 T021831_1 - 2.7e-27 95.3 1.6 2.7e-27 95.3 1.6 2.6 2 0 0 2 2 2 1 ADAM cysteine-rich Disintegrin PF00200.21 T021831_1 - 8.3e-21 74.5 24.3 8.3e-21 74.5 24.3 3.7 3 0 0 3 3 3 1 Disintegrin Pep_M12B_propep PF01562.17 T021831_1 - 4e-14 52.9 0.0 7.7e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 T021831_1 - 1.3e-13 51.4 0.0 2.2e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T021831_1 - 1.9e-09 38.0 0.0 3.1e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T021831_1 - 9.8e-07 28.7 0.0 1.7e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T021831_1 - 6.3e-05 22.6 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like CD20 PF04103.13 T021831_1 - 0.0099 15.8 0.2 0.019 14.9 0.2 1.4 1 0 0 1 1 1 1 CD20-like family Peptidase_M10 PF00413.22 T021831_1 - 0.12 12.1 0.1 0.19 11.4 0.1 1.2 1 0 0 1 1 1 0 Matrixin Ephrin PF00812.15 T021831_2 - 2.4e-36 124.6 0.0 4.1e-36 123.9 0.0 1.3 1 0 0 1 1 1 1 Ephrin CEBP_ZZ PF16366.3 T021831_2 - 0.83 9.8 11.7 2.2 8.4 11.7 1.7 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain DUF1272 PF06906.9 T021831_2 - 3.4 7.7 10.5 12 6.0 10.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) P66_CC PF16563.3 T170945_2 - 1.2e-19 69.5 11.3 2.2e-19 68.6 11.3 1.5 1 0 0 1 1 1 1 Coiled-coil and interaction region of P66A and P66B with MBD2 GATA PF00320.25 T170945_2 - 2.4e-07 30.1 7.1 8.1e-07 28.4 7.1 2.0 1 0 0 1 1 1 1 GATA zinc finger DUF2299 PF10061.7 T170945_2 - 0.26 10.9 0.3 0.47 10.1 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2299) PMP22_Claudin PF00822.18 T152824_2 - 3.7e-22 78.8 2.9 8e-22 77.7 2.9 1.5 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 T152824_2 - 2e-21 76.5 2.7 3.3e-21 75.8 2.7 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction CD20 PF04103.13 T152824_2 - 0.032 14.2 0.1 0.032 14.2 0.1 3.0 2 1 1 3 3 3 0 CD20-like family COPI_assoc PF08507.8 T152824_2 - 0.042 13.8 0.7 0.042 13.8 0.7 1.7 2 0 0 2 2 2 0 COPI associated protein DUF4199 PF13858.4 T152824_2 - 1.3 9.3 8.1 2.5 8.3 8.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) zf-DHHC PF01529.18 T152824_2 - 2.6 8.0 6.9 0.33 10.9 1.6 2.2 2 1 0 2 2 2 0 DHHC palmitoyltransferase Mab-21 PF03281.12 T017987_1 - 1.5e-82 277.1 3.9 2e-82 276.7 3.9 1.2 1 0 0 1 1 1 1 Mab-21 protein DUF4407 PF14362.4 T017987_2 - 1.8 7.7 4.4 2.8 7.1 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Apyrase PF06079.9 T155724_1 - 1.8e-130 434.3 0.1 2.3e-130 433.9 0.1 1.1 1 0 0 1 1 1 1 Apyrase SRCR PF00530.16 T155724_1 - 1.5e-29 102.3 1.5 3.9e-29 101.0 1.5 1.8 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain BACK PF07707.13 T155724_1 - 3.5e-11 43.0 0.0 5.7e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch SRCR_2 PF15494.4 T155724_1 - 0.0025 18.2 0.7 0.025 15.0 0.0 2.5 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain EnY2 PF10163.7 T349481_2 - 1.5e-33 114.8 0.8 2.5e-33 114.1 0.8 1.4 1 0 0 1 1 1 1 Transcription factor e(y)2 DUF3704 PF12488.6 T349481_2 - 1.1 8.8 6.5 0.08 12.5 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3704) EF-hand_1 PF00036.30 T174237_1 - 1.4e-10 39.8 0.5 0.044 13.2 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 T174237_1 - 5.1e-10 38.4 0.1 0.031 14.1 0.0 4.6 5 0 0 5 5 5 2 EF-hand domain EF-hand_8 PF13833.4 T174237_1 - 9.7e-07 28.3 1.2 3.8e-05 23.2 0.2 3.0 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.4 T174237_1 - 8.5e-06 26.0 1.1 3 8.3 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 T174237_1 - 3.8e-05 22.9 0.2 0.18 11.3 0.0 3.4 3 0 0 3 3 3 2 EF hand Methyltransf_23 PF13489.4 T200108_1 - 1.8e-17 63.6 0.0 2.9e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 T200108_1 - 1.9e-06 28.3 0.0 3.2e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T200108_1 - 0.0019 17.8 0.0 0.0032 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FAM193_C PF15914.3 T294379_1 - 1.8e-28 97.9 1.3 3.7e-28 96.9 1.3 1.5 1 0 0 1 1 1 1 FAM193 family C-terminal Ank_2 PF12796.5 T191540_3 - 1e-24 86.7 1.6 4e-11 43.2 0.1 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 T191540_3 - 2e-17 62.7 2.6 2.4e-07 30.8 0.2 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.4 T191540_3 - 2.3e-15 56.3 1.6 5.8e-09 35.9 0.1 3.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 T191540_3 - 4.3e-15 55.7 2.3 0.00016 22.0 0.1 4.6 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 T191540_3 - 7.6e-14 50.3 0.2 0.00058 20.0 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat RNase_Zc3h12a PF11977.6 T101862_1 - 9e-23 80.6 0.0 1.4e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain RNase_Zc3h12a PF11977.6 T101862_3 - 2.6e-31 108.4 0.0 3.6e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain HLH PF00010.24 T126457_3 - 2.9e-15 55.8 0.2 5.6e-15 54.9 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.3 T126457_3 - 0.11 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain Ank_2 PF12796.5 T223308_1 - 4.8e-36 123.1 14.7 5.9e-14 52.3 0.2 3.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T223308_1 - 3.9e-31 106.5 9.5 5.4e-09 36.0 0.1 3.9 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.4 T223308_1 - 3.5e-28 97.5 3.6 5.2e-08 33.1 0.1 6.3 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.28 T223308_1 - 4.3e-28 96.4 3.3 3.1e-06 27.3 0.1 6.9 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.4 T223308_1 - 3.7e-21 72.8 2.4 0.0022 18.2 0.1 6.2 6 0 0 6 6 6 5 Ankyrin repeat CCDC144C PF14915.4 T223308_1 - 1.7e-14 53.5 9.6 1.7e-14 53.5 9.6 3.1 2 1 1 3 3 3 1 CCDC144C protein coiled-coil region PWI PF01480.15 T005711_3 - 1.1e-29 102.4 0.2 1.8e-29 101.7 0.2 1.4 1 0 0 1 1 1 1 PWI domain ETRAMP PF09716.8 T005711_3 - 1.9 8.5 10.2 0.068 13.1 3.4 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DPPIV_N PF00930.19 T197431_2 - 4.6e-111 370.9 1.5 5.7e-111 370.5 1.5 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 T197431_2 - 1.7e-46 158.3 0.0 2.4e-46 157.8 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.16 T197431_2 - 6.2e-06 25.8 0.1 2.3e-05 23.9 0.1 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family PD40 PF07676.10 T197431_2 - 0.026 14.3 0.3 5 7.1 0.0 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Abhydrolase_2 PF02230.14 T197431_2 - 0.07 12.8 0.5 0.14 11.8 0.5 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.6 T197431_2 - 0.2 10.7 0.2 7.6 5.6 0.1 2.1 1 1 1 2 2 2 0 Serine aminopeptidase, S33 FGF PF00167.16 T339581_2 - 1.3e-06 28.4 0.0 2.1e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Fibroblast growth factor FGF PF00167.16 T339581_3 - 7.7e-16 58.2 0.5 1.3e-15 57.5 0.5 1.3 1 0 0 1 1 1 1 Fibroblast growth factor DUF1725 PF08333.9 T231986_1 - 0.0029 17.1 2.3 0.0053 16.3 2.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) HORMA PF02301.16 T231986_3 - 4.1e-20 72.1 0.0 5.9e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 HORMA domain DUF773 PF05600.10 T149529_1 - 3.6e-188 626.3 0.8 4.3e-188 626.1 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF773) SSF PF00474.15 T232509_2 - 2.8e-151 503.9 23.9 4.4e-151 503.2 23.9 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family DUF1725 PF08333.9 T232509_2 - 0.019 14.5 1.0 0.038 13.5 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Homeobox PF00046.27 T214896_3 - 5.3e-18 64.5 6.3 1.2e-17 63.4 6.3 1.6 1 0 0 1 1 1 1 Homeobox domain DNA_pol_B_exo1 PF03104.17 T179166_1 - 2.7e-32 112.1 0.0 3.6e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.19 T179166_2 - 6.8e-143 476.6 0.0 8.2e-143 476.3 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.17 T179166_2 - 8.6e-36 123.6 0.0 1.2e-35 123.1 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.4 T179166_2 - 5.2e-18 65.1 7.4 1.2e-17 64.0 7.4 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.11 T179166_2 - 0.18 10.4 0.0 0.28 9.8 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral I-set PF07679.14 T179166_3 - 3.9e-91 299.1 1.3 1.1e-18 66.9 0.0 7.4 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.4 T179166_3 - 1.3e-59 198.6 0.0 1.5e-11 44.6 0.0 7.7 7 0 0 7 7 7 7 Immunoglobulin domain fn3 PF00041.19 T179166_3 - 2.8e-41 139.6 0.3 3.2e-13 49.7 0.0 3.6 3 0 0 3 3 3 3 Fibronectin type III domain ig PF00047.23 T179166_3 - 7.4e-29 99.6 0.0 2.4e-09 37.1 0.0 7.3 7 0 0 7 7 7 4 Immunoglobulin domain Ig_2 PF13895.4 T179166_3 - 1.1e-26 92.8 0.2 3.3e-07 30.4 0.0 8.3 9 0 0 9 9 9 5 Immunoglobulin domain Hormone_recep PF00104.28 T179166_3 - 3.8e-26 91.8 0.2 5.7e-26 91.3 0.2 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 T179166_3 - 9.8e-24 83.5 15.9 2.7e-23 82.0 15.9 1.8 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Ets PF00178.20 T179166_3 - 2.2e-20 72.8 0.7 4.8e-20 71.7 0.7 1.6 1 0 0 1 1 1 1 Ets-domain V-set PF07686.15 T179166_3 - 2.3e-11 43.7 0.1 0.49 10.4 0.0 7.3 7 2 0 7 7 7 3 Immunoglobulin V-set domain MAPEG PF01124.16 T295009_1 - 4.1e-14 52.5 11.1 7.6e-14 51.6 11.1 1.4 1 0 0 1 1 1 1 MAPEG family Globin PF00042.20 T154883_2 - 1e-23 83.8 0.0 1.5e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Globin DUF3446 PF11928.6 T154883_2 - 4.5 7.5 12.3 0.061 13.5 4.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) FAM219A PF15260.4 T119658_2 - 1.2e-48 164.5 1.9 1.9e-48 163.8 1.9 1.3 1 0 0 1 1 1 1 Protein family FAM219A FA_hydroxylase PF04116.11 T291890_3 - 1.3e-20 73.9 16.3 3e-20 72.8 16.3 1.6 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily RhoGAP PF00620.25 T080584_1 - 4.2e-08 33.0 0.0 6.9e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain RhoGAP PF00620.25 T080584_2 - 1.4e-21 76.7 0.0 2.4e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 T080584_2 - 3.3e-09 37.1 0.0 6.6e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.4 T080584_2 - 8.7e-07 28.6 0.0 1.7e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.24 T080584_2 - 2.1e-06 27.4 0.0 8.1e-06 25.6 0.0 2.1 2 0 0 2 2 2 1 WW domain SH3_1 PF00018.26 T080584_2 - 1.7e-05 24.2 0.0 3.3e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 SH3 domain PH_9 PF15410.4 T080584_2 - 0.068 13.4 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain GHMP_kinases_C PF08544.11 T080584_2 - 0.11 12.8 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 GHMP kinases C terminal Sedlin_N PF04628.11 T371576_2 - 4.9e-44 149.5 0.6 7.9e-24 84.1 0.0 2.3 2 0 0 2 2 2 2 Sedlin, N-terminal conserved region Sybindin PF04099.10 T371576_2 - 6.5e-07 29.2 0.1 1.2e-06 28.4 0.1 1.3 1 0 0 1 1 1 1 Sybindin-like family MBD PF01429.17 T200682_2 - 0.02 14.5 0.0 0.12 12.0 0.0 2.2 2 0 0 2 2 2 0 Methyl-CpG binding domain DUF3697 PF12478.6 T021588_2 - 5.8e-15 55.0 0.2 1.2e-14 53.9 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-associated protein 2 UBA_4 PF14555.4 T021588_2 - 0.00068 19.3 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain DUF1296 PF06972.9 T021588_2 - 0.042 13.9 0.1 0.099 12.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) Comm PF15957.3 T021588_2 - 0.075 13.2 0.2 0.24 11.6 0.2 1.8 1 0 0 1 1 1 0 Commissureless CUE PF02845.14 T021588_2 - 0.73 9.5 2.1 0.65 9.6 0.2 1.9 2 0 0 2 2 2 0 CUE domain Isochorismatase PF00857.18 T288636_2 - 9.1e-24 84.4 0.0 1.3e-23 84.0 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family ig PF00047.23 T362043_1 - 4.3e-07 29.9 0.0 9.2e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 T362043_1 - 3.4e-06 27.4 3.0 3.4e-06 27.4 3.0 3.4 3 0 0 3 3 3 1 Plexin repeat Ig_3 PF13927.4 T362043_1 - 0.0056 17.1 0.0 0.017 15.6 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T362043_1 - 0.024 14.8 0.0 0.076 13.2 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain Ig_5 PF16681.3 T362043_1 - 0.029 14.7 0.0 0.069 13.4 0.0 1.6 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Sema PF01403.17 T362043_2 - 3.6e-149 497.0 0.0 4.7e-149 496.6 0.0 1.1 1 0 0 1 1 1 1 Sema domain I-set PF07679.14 T362043_2 - 0.0039 17.1 0.0 0.0085 16.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 T362043_2 - 0.024 14.8 0.0 0.059 13.6 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain DUF3891 PF13030.4 T362043_2 - 0.089 12.4 0.3 0.2 11.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3891) RR_TM4-6 PF06459.10 T174942_2 - 6.4e-42 144.2 0.0 1.7e-26 93.6 0.0 2.4 1 1 1 2 2 2 2 Ryanodine Receptor TM 4-6 RIH_assoc PF08454.9 T174942_2 - 5.6e-32 109.5 1.9 5.8e-32 109.4 0.2 2.0 2 0 0 2 2 2 1 RyR and IP3R Homology associated Ion_trans PF00520.29 T174942_2 - 2.8e-14 52.8 4.0 2.8e-14 52.8 4.0 2.1 2 0 0 2 2 2 1 Ion transport protein EF-hand_8 PF13833.4 T174942_2 - 4.6e-08 32.6 1.2 1e-07 31.4 0.0 2.3 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.4 T174942_2 - 0.014 15.7 0.1 0.048 14.0 0.1 2.0 1 0 0 1 1 1 0 EF-hand domain pair Asp_protease PF09668.8 T071748_2 - 0.0022 17.6 0.0 0.0032 17.1 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.4 T071748_2 - 0.0051 17.2 0.0 0.0084 16.5 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease TNFR_c6 PF00020.16 T375749_1 - 8.6e-10 38.7 35.1 7.4e-07 29.4 7.6 4.3 4 0 0 4 4 4 2 TNFR/NGFR cysteine-rich region FAM27 PF15832.3 T375749_2 - 0.52 10.8 5.5 0.97 9.9 5.5 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family SH3_9 PF14604.4 T046473_1 - 9.6e-37 124.5 0.6 2.9e-14 52.5 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 T046473_1 - 2.9e-35 119.5 0.4 3e-10 39.4 0.0 3.6 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 T046473_1 - 3.5e-28 96.9 0.2 7.9e-12 44.5 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 T046473_1 - 7.5e-21 73.4 0.3 1.7e-20 72.3 0.3 1.6 1 0 0 1 1 1 1 Sorbin homologous domain Ten_N PF06484.10 T292752_2 - 3.1e-81 274.0 20.6 4.9e-81 273.4 20.6 1.3 1 0 0 1 1 1 1 Teneurin Intracellular Region Tox-GHH PF15636.4 T292752_2 - 5.9e-31 106.1 0.7 1.1e-30 105.2 0.7 1.5 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin EGF_2 PF07974.11 T292752_2 - 5.8e-15 55.2 117.3 0.00025 21.2 11.3 7.3 7 0 0 7 7 7 6 EGF-like domain RHS_repeat PF05593.12 T292752_2 - 3.8e-11 43.1 39.0 0.0025 18.2 4.1 9.8 8 2 4 12 12 12 4 RHS Repeat NHL PF01436.19 T292752_2 - 3.6e-09 36.1 1.1 0.011 15.6 0.0 6.1 5 0 0 5 5 5 1 NHL repeat CarboxypepD_reg PF13620.4 T292752_2 - 0.00041 20.4 0.0 0.0018 18.4 0.0 2.1 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 T292752_2 - 0.0052 16.6 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 CarboxypepD_reg-like domain DUF2283 PF10049.7 T292752_2 - 0.19 11.9 0.4 54 4.0 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2283) WBP-1 PF11669.6 T192069_3 - 4.2e-42 142.9 4.2 4.2e-42 142.9 4.2 3.2 4 0 0 4 4 4 1 WW domain-binding protein 1 PAPA-1 PF04795.10 T192069_3 - 1.5e-17 64.0 0.3 1.5e-17 64.0 0.3 2.3 2 0 0 2 2 2 1 PAPA-1-like conserved region zf-HIT PF04438.14 T192069_3 - 1.7e-06 27.6 6.7 1.7e-06 27.6 6.7 2.1 2 0 0 2 2 2 1 HIT zinc finger DUF3619 PF12279.6 T192069_3 - 3.6 7.8 9.5 0.38 10.9 0.4 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3619) Oxysterol_BP PF01237.16 T010993_2 - 4.2e-81 272.5 8.2 4.2e-79 265.9 8.2 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein Snapin_Pallidin PF14712.4 T010993_2 - 0.24 11.8 3.8 0.062 13.6 0.6 1.6 2 0 0 2 2 2 0 Snapin/Pallidin RUN PF02759.17 T139573_1 - 1.7e-34 118.5 0.0 2.8e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 RUN domain zf-BED PF02892.13 T139573_1 - 0.014 15.3 0.0 0.055 13.4 0.0 2.0 1 0 0 1 1 1 0 BED zinc finger DUF3548 PF12068.6 T139573_1 - 0.021 14.3 0.0 0.83 9.1 0.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF3548) RabGAP-TBC PF00566.16 T139573_2 - 3.4e-31 108.4 6.0 6.6e-30 104.2 3.8 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Oxidored-like PF09791.7 T139573_3 - 2.2 7.9 11.8 0.7 9.5 0.3 3.0 2 0 0 2 2 2 0 Oxidoreductase-like protein, N-terminal RGS PF00615.17 T124102_1 - 9e-32 109.7 0.0 1.3e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain G-gamma PF00631.20 T124102_1 - 8.3e-10 38.4 0.0 2.1e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 GGL domain DEP PF00610.19 T124102_2 - 1.9e-15 56.5 0.0 2.7e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) I-set PF07679.14 T026558_1 - 0 2309.9 0.0 2.2e-20 72.3 0.0 44.4 44 0 0 44 44 44 44 Immunoglobulin I-set domain Ig_3 PF13927.4 T026558_1 - 0 2072.0 86.3 2.9e-16 59.7 0.0 44.6 44 0 0 44 44 44 44 Immunoglobulin domain Ig_2 PF13895.4 T026558_1 - 0 1412.6 47.3 2.1e-12 47.1 0.0 45.1 44 1 1 45 45 44 43 Immunoglobulin domain ig PF00047.23 T026558_1 - 0 1195.8 0.3 4.3e-10 39.5 0.0 45.2 44 1 0 44 44 44 44 Immunoglobulin domain V-set PF07686.15 T026558_1 - 2.2e-138 452.4 100.4 0.00051 20.0 0.0 68.4 49 28 8 57 57 55 28 Immunoglobulin V-set domain C2-set_2 PF08205.10 T026558_1 - 4.1e-109 356.8 49.4 0.00069 19.5 0.1 42.5 43 0 0 43 43 43 29 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 T026558_1 - 1.4e-83 275.3 0.0 0.069 13.4 0.0 40.1 43 0 0 43 43 41 12 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain TSP_1 PF00090.17 T026558_1 - 1.4e-60 201.1 128.3 7.9e-14 51.5 10.3 8.0 8 0 0 8 8 6 6 Thrombospondin type 1 domain EGF_CA PF07645.13 T026558_1 - 1.8e-56 188.0 99.0 1.9e-12 47.1 7.4 8.7 7 0 0 7 7 7 7 Calcium-binding EGF domain G2F PF07474.10 T026558_1 - 1.6e-55 187.5 0.1 3.6e-55 186.4 0.1 1.7 1 0 0 1 1 1 1 G2F domain C1-set PF07654.13 T026558_1 - 2.1e-50 169.0 18.0 0.52 10.7 0.0 32.2 36 0 0 36 36 33 9 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 T026558_1 - 3.1e-42 142.4 10.2 2.4 8.1 0.0 32.7 38 0 0 38 38 36 2 Izumo-like Immunoglobulin domain cEGF PF12662.5 T026558_1 - 1.8e-40 136.3 46.6 1.1e-10 41.1 1.8 8.3 7 0 0 7 7 7 6 Complement Clr-like EGF-like Receptor_2B4 PF11465.6 T026558_1 - 1.5e-27 95.8 13.5 0.52 10.4 0.0 24.7 30 0 0 30 30 27 3 Natural killer cell receptor 2B4 V-set_CD47 PF08204.9 T026558_1 - 2e-20 73.0 8.1 8 6.3 0.0 23.2 25 1 1 26 26 26 0 CD47 immunoglobulin-like domain C2-set PF05790.13 T026558_1 - 1.3e-17 63.6 0.0 50 4.1 0.0 20.4 27 0 0 27 27 23 0 Immunoglobulin C2-set domain FXa_inhibition PF14670.4 T026558_1 - 3.9e-09 36.5 112.8 1.4e-05 25.1 9.2 9.0 7 2 2 9 9 8 4 Coagulation Factor Xa inhibitory site Herpes_gI PF01688.15 T026558_1 - 2.8e-05 23.9 0.3 24 4.7 0.0 9.1 14 0 0 14 14 12 0 Alphaherpesvirus glycoprotein I A2M PF00207.20 T026558_1 - 3.4e-05 23.5 3.6 88 2.9 0.1 8.6 8 0 0 8 8 8 0 Alpha-2-macroglobulin family EGF_3 PF12947.5 T026558_1 - 0.00022 21.2 8.4 0.00022 21.2 8.4 8.2 7 0 0 7 7 7 5 EGF domain Pox_vIL-18BP PF05566.10 T026558_1 - 0.0049 16.9 0.7 25 5.0 0.0 6.5 7 0 0 7 7 5 0 Orthopoxvirus interleukin 18 binding protein VWA_2 PF13519.4 T026558_1 - 0.073 13.6 0.0 0.18 12.4 0.0 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain NID PF07292.11 T200952_3 - 3.8e-62 206.8 9.5 1e-31 109.3 0.1 2.9 3 0 0 3 3 3 2 Nmi/IFP 35 domain (NID) IFP_35_N PF07334.11 T200952_3 - 5.4e-39 132.0 10.1 8.4e-39 131.4 8.1 2.2 2 0 0 2 2 2 1 Interferon-induced 35 kDa protein (IFP 35) N-terminus Cnn_1N PF07989.9 T200952_3 - 0.013 15.4 2.2 0.013 15.4 2.2 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Rootletin PF15035.4 T200952_3 - 0.11 12.4 1.9 0.24 11.3 1.9 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion zf-CpG_bind_C PF12269.6 T200952_3 - 0.7 9.5 4.7 1.1 8.8 4.7 1.2 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain Bromodomain PF00439.23 T201677_3 - 1.2e-20 73.3 0.0 2.7e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain MBD PF01429.17 T201677_3 - 2.7e-20 71.7 0.0 5.7e-20 70.7 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain PHD PF00628.27 T201677_3 - 2.3e-11 43.3 9.2 6.9e-11 41.7 9.2 1.9 1 0 0 1 1 1 1 PHD-finger WSD PF15613.4 T201677_3 - 8.8e-11 42.1 0.1 4.5e-07 30.2 0.1 4.7 5 0 0 5 5 5 2 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.15 T201677_3 - 6.1e-09 35.9 0.3 1.3e-08 34.9 0.3 1.6 1 0 0 1 1 1 1 DDT domain RNA_pol_3_Rpc31 PF11705.6 T201677_3 - 0.0014 18.7 1.0 0.0014 18.7 1.0 6.3 5 2 0 5 5 5 1 DNA-directed RNA polymerase III subunit Rpc31 Sulfotransfer_2 PF03567.12 T160178_3 - 1.2e-61 208.7 2.2 1.7e-61 208.2 2.2 1.2 1 0 0 1 1 1 1 Sulfotransferase family Amelogenin PF02948.13 T371332_3 - 5.4e-70 235.4 56.8 7.2e-70 235.0 56.8 1.1 1 0 0 1 1 1 1 Amelogenin Taxilin PF09728.7 T007217_1 - 5.6e-116 387.0 77.5 7.9e-116 386.5 77.5 1.2 1 0 0 1 1 1 1 Myosin-like coiled-coil protein FlaC_arch PF05377.9 T007217_1 - 5 7.5 15.9 5.4 7.4 1.4 3.9 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) DCX PF03607.15 T007217_2 - 2.1e-33 114.1 0.0 1.7e-17 63.1 0.0 2.4 2 0 0 2 2 2 2 Doublecortin IQ PF00612.25 T007217_2 - 0.025 14.2 0.7 0.07 12.8 0.7 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF4061 PF13270.4 T007217_3 - 9.1e-07 29.0 0.0 1.5e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) Tho2 PF11262.6 T379676_3 - 7.6e-105 350.3 2.7 7.6e-105 350.3 2.7 4.3 5 2 1 6 6 6 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.3 T379676_3 - 1.4e-90 304.6 8.2 4.9e-64 216.9 5.6 4.1 2 1 1 3 3 3 2 THO complex subunit 2 N-terminus Thoc2 PF11732.6 T379676_3 - 5.5e-37 125.6 0.1 3.3e-36 123.0 0.2 2.3 2 0 0 2 2 2 1 Transcription- and export-related complex subunit Forkhead PF00250.16 T144547_2 - 1.5e-31 108.4 0.2 2.4e-31 107.7 0.2 1.3 1 0 0 1 1 1 1 Forkhead domain zf-H2C2_2 PF13465.4 T182010_1 - 5e-100 323.7 136.8 1.5e-07 31.4 0.3 19.0 19 0 0 19 19 19 16 Zinc-finger double domain zf-C2H2 PF00096.24 T182010_1 - 1.7e-59 194.9 151.1 3.1e-05 24.0 1.4 18.5 17 0 0 17 17 17 17 Zinc finger, C2H2 type KRAB PF01352.25 T182010_1 - 1.5e-39 133.3 3.4 2.1e-20 72.0 0.4 2.4 2 0 0 2 2 2 2 KRAB box zf-C2H2_4 PF13894.4 T182010_1 - 1.1e-27 94.1 144.7 0.021 15.5 1.4 18.9 17 0 0 17 17 17 15 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T182010_1 - 1.4e-07 31.2 114.3 0.00033 20.4 0.3 17.1 17 0 0 17 17 17 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T182010_1 - 0.00012 22.0 84.0 0.07 13.1 2.2 10.1 7 1 3 10 10 10 8 Zinc ribbon domain SH3_9 PF14604.4 T046509_1 - 7.5e-37 124.8 0.6 2.7e-14 52.6 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 T046509_1 - 2.3e-35 119.8 0.4 2.8e-10 39.5 0.0 3.5 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 T046509_1 - 2.8e-28 97.2 0.2 7.3e-12 44.7 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 T046509_1 - 5.8e-23 80.2 1.3 1.1e-22 79.3 1.3 1.5 1 0 0 1 1 1 1 Sorbin homologous domain PS_Dcarbxylase PF02666.13 T232385_2 - 2.7e-67 226.1 0.0 3.8e-67 225.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase PQ-loop PF04193.12 T004700_1 - 2.1e-12 46.5 1.6 3.8e-12 45.7 1.6 1.4 1 0 0 1 1 1 1 PQ loop repeat PQ-loop PF04193.12 T004700_3 - 6.6e-15 54.5 1.1 6.6e-15 54.5 1.1 1.7 2 0 0 2 2 2 1 PQ loop repeat Clusterin PF01093.15 T340984_3 - 1.3e-158 528.4 11.0 1.6e-158 528.2 11.0 1.1 1 0 0 1 1 1 1 Clusterin RE_AlwI PF09491.8 T340984_3 - 0.065 11.9 4.1 0.13 10.9 4.1 1.4 1 0 0 1 1 1 0 AlwI restriction endonuclease RPW8 PF05659.9 T340984_3 - 6.9 6.2 7.6 1.5 8.3 0.2 2.6 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 zf-C4pol PF14260.4 T340984_3 - 7 7.0 9.7 0.73 10.2 0.9 2.6 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta zf-RanBP PF00641.16 T013138_1 - 2e-12 46.0 22.2 1.7e-06 27.1 3.7 2.6 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others Rrn6 PF10214.7 T013138_1 - 0.013 13.9 9.2 0.018 13.4 9.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor RSRP PF17069.3 T013138_1 - 0.081 12.4 15.7 0.13 11.7 15.7 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 BUD22 PF09073.8 T013138_1 - 0.11 11.6 23.1 0.16 11.1 23.1 1.1 1 0 0 1 1 1 0 BUD22 Apt1 PF10351.7 T013138_1 - 0.16 10.7 9.5 0.22 10.2 9.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF35_N PF12172.6 T013138_1 - 0.51 10.1 5.8 0.81 9.5 0.2 2.5 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) SR-25 PF10500.7 T013138_1 - 0.84 9.1 18.3 1.4 8.3 18.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Nop14 PF04147.10 T013138_1 - 1.2 7.2 16.1 1.5 6.8 16.1 1.0 1 0 0 1 1 1 0 Nop14-like family HpaP PF09483.8 T077071_2 - 3.4 8.0 8.7 5 7.5 8.7 1.2 1 0 0 1 1 1 0 Type III secretion protein (HpaP) Lge1 PF11488.6 T077071_3 - 2.7e-14 53.3 0.2 5.2e-14 52.4 0.2 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 HERV-K_REC PF15695.3 T077071_3 - 0.0015 18.4 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Ion_trans PF00520.29 T066355_1 - 8.2e-35 120.1 16.7 1.3e-34 119.4 16.7 1.3 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.9 T066355_1 - 3.6e-26 91.0 0.8 6.9e-26 90.1 0.8 1.5 1 0 0 1 1 1 1 Transient receptor ion channel II PKD_channel PF08016.10 T066355_1 - 2e-13 49.7 14.5 2.9e-13 49.2 14.5 1.2 1 0 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.5 T066355_1 - 2.4e-10 40.7 0.4 4.1e-07 30.4 0.3 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T066355_1 - 0.00014 22.2 0.5 0.0012 19.3 0.1 2.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 T066355_1 - 0.00096 19.3 1.4 0.17 12.2 0.2 3.9 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 T066355_1 - 0.021 15.2 2.5 27 5.6 0.0 4.4 4 0 0 4 4 4 0 Ankyrin repeat Ank PF00023.28 T066355_1 - 0.29 11.6 1.4 37 4.9 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeat ING PF12998.5 T066355_1 - 0.53 10.7 3.6 2.7 8.5 1.6 2.4 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Ank_2 PF12796.5 T269830_2 - 3.9e-145 472.7 46.0 1.3e-17 64.0 1.4 12.1 1 1 11 12 12 12 12 Ankyrin repeats (3 copies) Ank PF00023.28 T269830_2 - 1e-128 414.5 68.7 9.7e-07 28.8 0.5 23.2 23 0 0 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 T269830_2 - 5.8e-121 393.3 32.4 3.3e-12 46.5 0.1 14.9 8 4 8 17 17 17 16 Ankyrin repeats (many copies) Ank_5 PF13857.4 T269830_2 - 8.8e-115 372.6 48.7 5e-11 42.5 0.6 18.2 2 2 17 20 20 20 19 Ankyrin repeats (many copies) Ank_3 PF13606.4 T269830_2 - 6.8e-107 336.2 34.6 6.9e-05 22.8 0.0 23.7 23 0 0 23 23 23 20 Ankyrin repeat ZU5 PF00791.18 T269830_2 - 1.4e-38 131.0 0.6 1.3e-15 57.4 0.0 3.8 2 1 1 3 3 3 3 ZU5 domain Death PF00531.20 T269830_2 - 9.4e-22 76.9 0.9 2e-21 75.8 0.9 1.6 1 0 0 1 1 1 1 Death domain PK_C PF02887.14 T269830_2 - 4.6e-05 23.5 2.3 13 5.9 0.0 5.8 5 1 1 6 6 6 2 Pyruvate kinase, alpha/beta domain FH2 PF02181.21 T318149_1 - 8.1e-71 239.0 0.4 1.2e-70 238.4 0.4 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain PDZ PF00595.22 T318149_2 - 3.8e-22 78.3 0.0 6.9e-12 45.4 0.0 2.3 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T318149_2 - 5.6e-08 32.9 0.0 0.014 15.6 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDEase_I PF00233.17 T291276_3 - 4.8e-27 95.1 0.3 7.6e-27 94.4 0.3 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase zf-H2C2_2 PF13465.4 T182065_1 - 1.2e-56 186.6 72.4 1.1e-07 31.8 0.7 12.0 11 1 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 T182065_1 - 1.8e-40 135.0 75.0 0.00011 22.3 0.2 10.9 10 0 0 10 10 10 9 Zinc finger, C2H2 type KRAB PF01352.25 T182065_1 - 1.1e-22 79.2 1.0 1.9e-22 78.5 1.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T182065_1 - 7.6e-14 51.1 69.1 0.16 12.7 0.2 11.2 9 0 0 9 9 9 9 C2H2-type zinc finger GP41 PF00517.15 T182065_1 - 4.5e-10 39.6 6.1 4.5e-10 39.6 6.1 2.7 2 1 1 3 3 3 1 Retroviral envelope protein zf-C2H2_6 PF13912.4 T182065_1 - 0.00028 20.6 54.4 0.4 10.6 1.3 9.8 9 0 0 9 9 9 5 C2H2-type zinc finger C1_1 PF00130.20 T182065_1 - 0.0011 18.7 23.8 0.22 11.3 0.6 6.8 3 3 0 5 5 5 3 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.8 T182065_1 - 0.011 15.7 39.2 1.1 9.3 2.3 6.1 4 1 1 5 5 5 0 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T182065_1 - 0.28 11.8 32.1 0.53 10.9 0.4 5.8 2 1 6 8 8 8 0 zinc-ribbon family zf-H2C2_2 PF13465.4 T182065_2 - 1.4e-59 195.8 106.5 4.2e-07 30.0 2.3 15.7 16 1 0 16 16 16 11 Zinc-finger double domain zf-C2H2 PF00096.24 T182065_2 - 7.7e-46 151.9 107.1 0.00017 21.7 0.4 13.7 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T182065_2 - 6.9e-12 45.0 102.9 0.4 11.5 1.0 14.1 13 0 0 13 13 13 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T182065_2 - 0.00027 20.8 49.1 0.54 10.3 2.1 7.0 4 1 3 7 7 7 5 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T182065_2 - 0.0047 17.5 36.8 2.8 8.6 0.9 6.7 2 1 7 9 9 9 8 zinc-ribbon family zf-C2H2_6 PF13912.4 T182065_2 - 0.76 9.7 70.9 0.45 10.4 0.5 11.7 11 0 0 11 11 11 0 C2H2-type zinc finger KRAB PF01352.25 T182065_3 - 9.6e-23 79.5 1.0 1.9e-22 78.5 1.0 1.5 1 0 0 1 1 1 1 KRAB box PAX PF00292.16 T197098_1 - 7.9e-27 93.5 0.8 1.3e-26 92.8 0.8 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.4 T197098_1 - 0.014 15.0 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Pax2_C PF12403.6 T197098_3 - 4.9e-53 177.9 15.5 1.1e-52 176.8 15.5 1.6 1 0 0 1 1 1 1 Paired-box protein 2 C terminal PAX PF00292.16 T197098_3 - 1.7e-35 121.5 0.1 2.9e-35 120.8 0.1 1.3 1 0 0 1 1 1 1 'Paired box' domain COX6B PF02297.15 T181278_1 - 5.5e-16 58.4 2.1 1.1e-15 57.5 2.1 1.5 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb 7tm_1 PF00001.19 T313912_1 - 2e-53 181.2 25.3 3.9e-53 180.3 25.3 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) p450 PF00067.20 T329245_1 - 9e-56 189.4 0.1 8.9e-51 172.9 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 RVT_1 PF00078.25 T329245_1 - 8.8e-21 74.3 0.9 8.8e-21 74.3 0.9 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T329245_1 - 0.0016 17.9 2.5 0.0043 16.5 2.5 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T329245_2 - 2.9e-143 477.0 22.8 4.5e-143 476.4 22.8 1.3 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T329245_2 - 2.7e-24 85.8 0.1 4.5e-24 85.1 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Syntaxin-6_N PF09177.9 T329245_2 - 0.00055 20.3 7.3 0.0017 18.7 7.3 1.9 1 0 0 1 1 1 1 Syntaxin 6, N-terminal Seryl_tRNA_N PF02403.20 T329245_2 - 0.0042 17.2 6.0 0.0042 17.2 6.0 2.5 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain GCN5L1 PF06320.11 T329245_2 - 0.038 14.0 4.7 0.019 15.0 1.4 2.1 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) ATG16 PF08614.9 T329245_2 - 0.2 11.7 16.1 0.3 11.1 12.9 2.5 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) XhlA PF10779.7 T329245_2 - 3.8 7.6 10.7 0.53 10.4 2.2 2.7 2 0 0 2 2 2 0 Haemolysin XhlA DUF16 PF01519.14 T329245_2 - 3.9 7.9 13.6 3 8.3 8.0 3.0 2 1 0 2 2 2 0 Protein of unknown function DUF16 Ig_2 PF13895.4 T176471_1 - 1.9e-25 88.9 2.3 7e-15 55.0 0.3 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 T176471_1 - 1.3e-23 83.2 3.5 2.4e-09 37.6 0.1 3.8 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T176471_1 - 1.9e-15 56.8 0.2 4.7e-10 39.5 0.0 3.9 3 1 1 4 4 4 2 Immunoglobulin V-set domain ig PF00047.23 T176471_1 - 3.9e-13 49.2 1.1 0.0012 18.9 0.1 3.8 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T176471_1 - 9.5e-11 41.5 0.1 0.0088 16.0 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin I-set domain C2-set PF05790.13 T176471_1 - 0.072 13.1 0.0 2.1 8.4 0.1 2.7 2 0 0 2 2 2 0 Immunoglobulin C2-set domain Ten_N PF06484.10 T292756_3 - 3.1e-81 274.0 20.6 5e-81 273.3 20.6 1.3 1 0 0 1 1 1 1 Teneurin Intracellular Region Tox-GHH PF15636.4 T292756_3 - 6e-31 106.0 0.7 1.1e-30 105.2 0.7 1.5 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin EGF_2 PF07974.11 T292756_3 - 6.6e-21 74.3 159.2 0.00025 21.2 11.3 9.3 9 0 0 9 9 9 8 EGF-like domain RHS_repeat PF05593.12 T292756_3 - 2.7e-11 43.6 38.4 0.0025 18.1 4.1 9.7 8 2 4 12 12 12 4 RHS Repeat NHL PF01436.19 T292756_3 - 3.7e-09 36.0 1.1 0.011 15.6 0.0 6.2 5 0 0 5 5 5 1 NHL repeat CarboxypepD_reg PF13620.4 T292756_3 - 0.00042 20.4 0.0 0.0018 18.4 0.0 2.1 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 T292756_3 - 0.0053 16.6 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 CarboxypepD_reg-like domain DUF2283 PF10049.7 T292756_3 - 0.2 11.9 0.4 55 4.0 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2283) Sec6 PF06046.11 T110940_2 - 1.1e-108 364.0 0.0 1.4e-108 363.7 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec6 SR-25 PF10500.7 T110940_2 - 0.055 12.9 4.6 0.1 12.1 4.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PHR PF08005.10 T165914_1 - 2.5e-52 177.4 0.9 3.6e-52 176.9 0.9 1.2 1 0 0 1 1 1 1 PHR domain BTB PF00651.29 T165914_1 - 7.1e-28 96.9 0.2 3.1e-27 94.8 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.13 T165914_1 - 7.8e-08 32.2 0.3 1.8e-07 31.0 0.1 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Pkinase PF00069.23 T165914_3 - 4.1e-63 213.1 0.0 5.7e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T165914_3 - 7.6e-27 94.1 0.0 1.1e-26 93.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 T165914_3 - 0.00013 21.3 0.1 0.0002 20.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RRN7 PF11781.6 T165914_3 - 1.4 8.5 7.0 0.038 13.6 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 GYF PF02213.14 T209803_1 - 1.8e-20 72.3 0.4 3.6e-20 71.3 0.4 1.6 1 0 0 1 1 1 1 GYF domain DUF4339 PF14237.4 T209803_1 - 0.0054 16.4 0.1 0.013 15.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4339) PID PF00640.21 T281325_2 - 4.2e-08 33.2 0.0 1.7e-07 31.3 0.0 1.9 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) zf-C2H2_assoc3 PF16637.3 T281325_2 - 2.2 8.6 4.6 4.9 7.5 0.1 2.8 2 0 0 2 2 2 0 Putative zinc-finger between two C2H2 zinc-fingers on Patz PMSI1 PF15322.4 T020664_2 - 1.6e-157 523.6 11.8 1.6e-157 523.6 11.8 1.7 2 0 0 2 2 2 1 Protein missing in infertile sperm 1, putative DHHA2 PF02833.12 T020664_2 - 5.7e-29 101.0 0.1 1.5e-28 99.6 0.0 1.7 2 0 0 2 2 2 1 DHHA2 domain DHH PF01368.18 T020664_2 - 1.1e-08 35.1 0.4 1.9e-08 34.3 0.4 1.3 1 0 0 1 1 1 1 DHH family BNIP2 PF12496.6 T020664_3 - 3.4e-37 127.8 0.0 4.9e-37 127.3 0.0 1.2 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 T020664_3 - 2.5e-32 111.7 0.1 3.7e-32 111.2 0.1 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 T020664_3 - 5.1e-08 32.7 0.0 1e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain Popeye PF04831.11 T205799_1 - 1.1 9.3 6.7 1.9 8.5 6.7 1.2 1 0 0 1 1 1 0 Popeye protein conserved region Peptidase_C14 PF00656.20 T205799_2 - 6.4e-53 180.1 0.1 1e-52 179.4 0.1 1.3 1 0 0 1 1 1 1 Caspase domain DED PF01335.19 T205799_2 - 6.9e-43 144.7 18.7 3.5e-22 78.4 6.6 2.5 2 0 0 2 2 2 2 Death effector domain PYRIN PF02758.14 T205799_2 - 4.8 7.3 6.1 0.46 10.6 0.3 2.2 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain Ifi-6-16 PF06140.11 T109384_2 - 5.2e-27 93.4 26.0 5.2e-27 93.4 26.0 2.4 2 0 0 2 2 2 1 Interferon-induced 6-16 family Ifi-6-16 PF06140.11 T109384_3 - 3.6e-24 84.3 30.6 6.6e-24 83.5 30.6 1.4 1 0 0 1 1 1 1 Interferon-induced 6-16 family BC10 PF06726.10 T217380_2 - 1.2e-24 86.1 10.2 4.9e-24 84.2 10.2 2.2 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 CK2S PF15011.4 T008256_3 - 1.6e-55 187.2 1.7 2.2e-55 186.8 1.7 1.2 1 0 0 1 1 1 1 Casein Kinase 2 substrate NAP PF00956.16 T367220_1 - 2.9e-38 131.5 12.9 6.1e-33 114.0 4.1 2.5 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Phage_Mu_Gam PF07352.10 T367220_1 - 0.023 14.5 2.6 0.038 13.8 2.6 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Nore1-SARAH PF16517.3 T367220_1 - 0.18 11.6 1.4 1.1 9.2 1.5 2.2 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain ZapB PF06005.10 T367220_1 - 0.5 10.7 5.0 1 9.7 5.0 1.4 1 0 0 1 1 1 0 Cell division protein ZapB OmpH PF03938.12 T367220_1 - 1.4 8.7 6.0 2.8 7.8 6.0 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) RasGEF PF00617.17 T120402_1 - 1.2e-54 184.9 0.3 1.8e-54 184.4 0.3 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 T120402_2 - 3.5e-20 72.1 0.2 1.6e-16 60.3 0.1 2.3 2 0 0 2 2 2 2 RasGEF N-terminal motif Glyco_transf_10 PF00852.17 T166902_3 - 1.6e-132 438.2 1.3 9.6e-67 224.0 0.5 2.2 2 0 0 2 2 2 2 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 T166902_3 - 2.8e-70 233.6 0.1 1.2e-35 122.1 0.0 2.4 2 0 0 2 2 2 2 Fucosyltransferase, N-terminal C2 PF00168.28 T006336_1 - 1.4e-28 99.1 0.0 2e-14 53.6 0.0 2.2 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 T006336_2 - 2.3e-05 24.4 0.1 4.6e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger zf-MIZ PF02891.18 T322805_2 - 1.2e-22 79.3 4.5 1.2e-22 79.3 4.5 2.9 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 T322805_2 - 3.7e-05 23.3 1.1 3.7e-05 23.3 1.1 2.1 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Sugar_tr PF00083.22 T230770_1 - 7e-16 58.0 3.3 1.1e-15 57.4 3.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Sugar_tr PF00083.22 T230770_2 - 5.7e-52 177.0 3.7 1.7e-41 142.4 3.0 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MIF PF01187.16 T230770_3 - 4.8e-49 165.3 0.0 7.1e-49 164.7 0.0 1.3 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) IPK PF03770.14 T115023_1 - 1.6e-39 135.7 0.0 1.6e-39 135.7 0.0 2.5 2 0 0 2 2 2 1 Inositol polyphosphate kinase Plus-3 PF03126.16 T115023_1 - 4.3e-36 123.6 0.1 4.3e-36 123.6 0.1 2.0 2 0 0 2 2 2 1 Plus-3 domain NACHT PF05729.10 T320931_1 - 8.4e-41 139.5 0.0 1.8e-40 138.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain CARD PF00619.19 T320931_1 - 4.1e-17 61.8 0.2 1e-16 60.6 0.2 1.6 1 0 0 1 1 1 1 Caspase recruitment domain LRR_6 PF13516.4 T320931_1 - 0.0048 16.7 2.2 0.028 14.3 0.0 2.9 3 0 0 3 3 3 1 Leucine Rich repeat AAA_18 PF13238.4 T320931_1 - 0.045 14.1 0.0 0.078 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 T320931_1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain LRR_6 PF13516.4 T320931_3 - 5e-11 41.6 3.7 0.00098 18.9 0.1 6.7 6 1 1 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.5 T320931_3 - 0.00024 21.3 3.9 0.013 15.7 0.2 3.4 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) TNFR_c6 PF00020.16 T340473_2 - 3.9e-15 55.8 39.7 3.7e-08 33.5 9.4 4.8 3 1 1 4 4 4 4 TNFR/NGFR cysteine-rich region Glyco_transf_29 PF00777.16 T256571_1 - 1.5e-35 122.7 0.0 2.5e-35 122.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) MORN PF02493.18 T318076_2 - 9.9e-19 65.9 24.0 1.5e-06 27.6 0.4 5.6 5 0 0 5 5 5 5 MORN repeat MORN PF02493.18 T318076_3 - 7.5e-18 63.2 28.9 5.7e-06 25.8 1.5 5.1 5 0 0 5 5 5 4 MORN repeat Cupin_4 PF08007.10 T246543_1 - 1.3e-98 330.3 0.0 1.6e-98 330.0 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.4 T246543_1 - 2.3e-05 24.2 0.1 0.024 14.3 0.1 2.2 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.9 T246543_1 - 0.0034 16.9 0.2 0.11 12.1 0.2 2.5 1 1 0 1 1 1 1 Cupin domain ASC PF00858.22 T145537_1 - 6.1e-95 318.4 0.0 9.3e-95 317.8 0.0 1.3 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel TPR_19 PF14559.4 T240460_1 - 5.4e-15 55.5 13.5 3.1e-05 24.2 0.2 5.7 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.15 T240460_1 - 1.3e-12 46.6 11.9 0.0018 18.2 0.5 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.5 T240460_1 - 3.7e-12 46.1 3.4 0.0011 18.9 0.2 3.7 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.4 T240460_1 - 4.1e-12 46.4 0.9 0.0056 17.2 1.5 5.4 6 1 0 6 6 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 T240460_1 - 9.8e-12 44.0 17.4 0.00019 21.0 0.4 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.4 T240460_1 - 6.5e-11 42.0 4.4 0.47 11.3 0.1 7.0 5 1 1 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.4 T240460_1 - 2.4e-10 39.7 8.8 0.0093 16.0 0.4 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.4 T240460_1 - 6.5e-07 28.8 10.4 0.18 11.4 0.3 5.0 4 1 1 5 5 5 3 TPR repeat TPR_12 PF13424.4 T240460_1 - 9.1e-06 25.7 9.6 0.033 14.3 2.3 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.4 T240460_1 - 0.0057 16.8 1.8 0.65 10.4 0.0 3.9 5 0 0 5 5 4 1 Tetratricopeptide repeat NARP1 PF12569.6 T240460_1 - 0.022 13.5 5.6 0.39 9.4 0.9 2.7 3 1 0 3 3 3 0 NMDA receptor-regulated protein 1 TPR_7 PF13176.4 T240460_1 - 0.023 14.6 9.1 2 8.5 0.6 5.2 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.4 T240460_1 - 0.036 14.6 7.7 14 6.4 0.0 5.7 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_9 PF13371.4 T240460_1 - 0.045 13.8 1.7 8.3 6.5 0.2 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat SRP_TPR_like PF17004.3 T240460_1 - 0.087 12.7 0.3 0.76 9.7 0.4 2.2 2 1 0 2 2 2 0 Putative TPR-like repeat TPR_19 PF14559.4 T240460_2 - 4.5e-23 81.4 15.1 1e-05 25.8 0.9 9.5 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.4 T240460_2 - 4.6e-20 70.5 2.3 0.049 14.3 0.0 10.0 6 2 5 11 11 11 4 Tetratricopeptide repeat TPR_2 PF07719.15 T240460_2 - 6.8e-15 53.8 28.4 0.42 10.7 0.1 11.7 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_11 PF13414.4 T240460_2 - 9.7e-09 34.7 9.5 0.17 11.5 0.0 5.9 4 1 1 5 5 5 3 TPR repeat TPR_16 PF13432.4 T240460_2 - 4.1e-08 33.7 0.8 2.7 8.6 0.0 7.3 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_12 PF13424.4 T240460_2 - 8.4e-07 29.1 10.3 5.3 7.3 0.3 8.5 8 2 0 8 8 8 1 Tetratricopeptide repeat TPR_1 PF00515.26 T240460_2 - 7e-06 25.5 37.2 1.9 8.3 0.1 10.8 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_6 PF13174.4 T240460_2 - 7.8e-06 26.1 21.6 0.32 11.6 0.0 9.4 11 0 0 11 11 9 2 Tetratricopeptide repeat TPR_17 PF13431.4 T240460_2 - 4.2e-05 23.5 0.2 11 6.5 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.4 T240460_2 - 0.00034 20.5 17.4 7.1 7.0 0.1 8.4 9 0 0 9 9 9 1 Tetratricopeptide repeat ANAPC3 PF12895.5 T240460_2 - 0.00051 20.1 22.7 0.85 9.7 2.8 7.3 5 2 2 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.4 T240460_2 - 0.0026 17.6 1.3 0.11 12.4 0.0 3.8 5 0 0 5 5 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.7 T240460_2 - 0.013 15.2 5.3 0.1 12.2 0.5 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain PPR PF01535.18 T240460_2 - 0.028 14.5 0.7 12 6.3 0.0 4.8 5 0 0 5 5 5 0 PPR repeat TPR_15 PF13429.4 T240460_2 - 0.031 13.3 6.7 0.91 8.5 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.4 T240460_2 - 0.054 13.4 12.3 3 8.0 0.2 5.8 6 0 0 6 6 5 0 Tetratricopeptide repeat RPN7 PF10602.7 T240460_2 - 1.7 8.1 5.5 45 3.5 0.1 4.2 5 0 0 5 5 5 0 26S proteasome subunit RPN7 UPF0004 PF00919.18 T298473_1 - 5.3e-21 74.4 0.1 1.3e-20 73.1 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.19 T298473_1 - 1.7e-17 64.1 0.1 2.7e-17 63.5 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily SDF PF00375.16 T281054_3 - 2.2e-132 441.7 30.9 2.7e-132 441.4 30.9 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family MT PF12777.5 T281054_3 - 0.048 12.5 0.0 0.076 11.9 0.0 1.2 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor Neurochondrin PF05536.9 T007895_1 - 1.5e-209 696.9 0.0 1.8e-209 696.6 0.0 1.1 1 0 0 1 1 1 1 Neurochondrin TF_AP-2 PF03299.12 T007895_1 - 2.4e-85 285.3 0.0 3.6e-85 284.8 0.0 1.3 1 0 0 1 1 1 1 Transcription factor AP-2 Sugar_tr PF00083.22 T366753_3 - 7.3e-100 334.8 22.2 1.1e-99 334.2 22.2 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 T366753_3 - 3.6e-21 75.4 46.2 6.5e-21 74.5 43.0 2.3 2 0 0 2 2 2 1 Major Facilitator Superfamily RskA PF10099.7 T366753_3 - 0.035 14.3 2.6 0.087 13.0 2.6 1.6 1 0 0 1 1 1 0 Anti-sigma-K factor rskA ITI_HC_C PF06668.10 T375205_1 - 7.7e-41 139.7 0.0 1.2e-40 139.0 0.0 1.3 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VWA PF00092.26 T375205_1 - 7.4e-19 68.5 0.0 1e-18 68.0 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 T375205_1 - 3.5e-16 59.4 0.0 5.3e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 T375205_1 - 4.1e-11 43.4 0.0 7.4e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Aminotran_5 PF00266.17 T217011_1 - 1.1e-90 304.2 0.0 1.4e-90 303.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 T217011_1 - 1.1e-08 34.6 0.0 1.7e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.15 T217011_1 - 0.00022 20.5 0.0 0.00033 20.0 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.17 T217011_1 - 0.049 12.2 0.0 0.08 11.5 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Myosin_head PF00063.19 T231260_2 - 9.4e-79 265.2 0.0 5.1e-70 236.4 0.0 2.8 2 1 0 2 2 2 2 Myosin head (motor domain) Myosin_tail_1 PF01576.17 T231260_2 - 8.5e-08 30.4 110.7 1.1e-07 30.1 77.2 2.7 1 1 1 2 2 2 2 Myosin tail IQ PF00612.25 T231260_2 - 0.013 15.1 2.8 0.018 14.7 0.0 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_22 PF13401.4 T231260_2 - 0.022 14.9 1.6 0.087 13.0 0.0 3.0 2 0 0 2 2 2 0 AAA domain TFIID-31kDa PF02291.13 T231260_2 - 0.036 14.0 1.9 0.085 12.8 1.9 1.5 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit AAA_18 PF13238.4 T231260_2 - 4.5 7.7 7.0 8.4 6.8 0.0 3.8 3 0 0 3 3 3 0 AAA domain HOOK PF05622.10 T231260_3 - 0.0089 14.1 7.7 0.013 13.6 7.7 1.1 1 0 0 1 1 1 1 HOOK protein KxDL PF10241.7 T231260_3 - 0.054 13.6 2.8 0.12 12.5 2.8 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein DUF4164 PF13747.4 T231260_3 - 0.14 12.3 9.8 0.28 11.3 9.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Nup54 PF13874.4 T231260_3 - 0.16 11.9 6.9 0.32 11.0 6.9 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 AIP3 PF03915.11 T231260_3 - 0.24 10.3 4.1 0.36 9.7 4.1 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 DUF572 PF04502.11 T231260_3 - 0.43 9.9 7.5 0.76 9.1 7.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) APG6 PF04111.10 T231260_3 - 0.58 9.4 6.5 0.84 8.8 6.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 T231260_3 - 0.82 9.3 10.6 1.5 8.4 10.6 1.3 1 0 0 1 1 1 0 IncA protein DUF1640 PF07798.9 T231260_3 - 0.85 9.5 6.4 1.4 8.9 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Prominin PF05478.9 T231260_3 - 1.7 6.4 2.6 2.4 5.8 2.6 1.1 1 0 0 1 1 1 0 Prominin Spc7 PF08317.9 T231260_3 - 2 7.1 9.4 3 6.5 9.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Glycogen_syn PF05693.11 T178475_1 - 1.7e-68 231.6 0.5 2.4e-68 231.1 0.5 1.1 1 0 0 1 1 1 1 Glycogen synthase Glycogen_syn PF05693.11 T178475_2 - 3.8e-147 491.4 0.0 5.2e-147 491.0 0.0 1.1 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.18 T178475_2 - 0.0018 17.8 0.0 0.003 17.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.4 T178475_2 - 0.031 14.6 0.0 0.058 13.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glycogen_syn PF05693.11 T178475_3 - 3.8e-125 418.8 0.0 5.2e-125 418.3 0.0 1.1 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.4 T178475_3 - 6.8e-05 22.8 0.3 0.00016 21.6 0.3 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Pkinase PF00069.23 T211707_2 - 4e-69 232.8 0.0 5.4e-69 232.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T211707_2 - 1.9e-50 171.5 0.0 2.8e-50 170.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1241 PF06840.9 T211707_2 - 0.0016 18.0 0.0 0.0027 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Kinase-like PF14531.4 T211707_2 - 0.074 12.2 0.0 0.19 10.9 0.0 1.6 2 0 0 2 2 2 0 Kinase-like zf-C2H2 PF00096.24 T186832_1 - 2.2e-05 24.5 21.7 0.012 15.9 2.3 6.0 5 0 0 5 5 5 3 Zinc finger, C2H2 type CpXC PF14353.4 T186832_1 - 0.00039 20.3 5.7 0.17 11.8 0.0 3.2 3 0 0 3 3 3 2 CpXC protein zf-C2H2_4 PF13894.4 T186832_1 - 0.0056 17.3 35.3 0.087 13.6 2.5 7.0 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2HE PF16278.3 T186832_1 - 0.037 14.4 12.5 4.3 7.8 3.6 4.7 3 1 1 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger Fibrinogen_BP PF08017.9 T186832_1 - 0.099 10.9 28.1 0.033 12.5 24.5 1.8 1 1 0 1 1 1 0 Fibrinogen binding protein zf-C2H2_aberr PF17017.3 T186832_1 - 0.46 10.5 10.5 21 5.1 0.3 3.7 3 0 0 3 3 3 0 Aberrant zinc-finger zf-C2H2_jaz PF12171.6 T186832_1 - 0.76 10.0 11.9 0.15 12.3 1.3 4.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Tristanin_u2 PF16638.3 T070378_3 - 3.1e-52 176.7 4.0 3.1e-52 176.7 4.0 3.1 3 1 0 3 3 2 1 Unstructured region on methyltransferase between zinc-fingers zf-C2H2 PF00096.24 T070378_3 - 2.1e-30 103.3 78.3 0.0001 22.4 2.5 11.2 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T070378_3 - 3.5e-26 89.5 74.0 0.0084 16.7 1.8 11.7 10 0 0 10 10 10 10 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T070378_3 - 9.6e-16 57.3 66.1 0.0017 18.6 1.6 11.9 11 1 0 11 11 11 8 Zinc-finger double domain zf-C2H2_jaz PF12171.6 T070378_3 - 7.3e-15 54.7 54.1 9.8e-05 22.4 0.4 10.3 11 0 0 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 T070378_3 - 9.7e-07 28.9 46.5 0.17 12.1 10.1 8.9 4 2 2 7 7 7 4 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.4 T070378_3 - 1.1e-06 28.3 50.3 0.0065 16.3 0.4 8.6 8 0 0 8 8 8 4 C2H2-type zinc finger zf-met PF12874.5 T070378_3 - 3.5e-05 23.9 4.7 0.00089 19.4 0.2 8.8 9 0 0 9 9 8 2 Zinc-finger of C2H2 type zf-Di19 PF05605.10 T070378_3 - 0.057 13.6 43.5 0.096 12.8 2.4 7.6 6 1 1 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding SET PF00856.26 T070378_3 - 0.071 13.4 0.0 0.34 11.1 0.0 2.1 2 1 0 2 2 2 0 SET domain DUF629 PF04780.10 T070378_3 - 0.4 9.0 34.5 0.84 8.0 0.0 6.6 4 1 1 6 6 6 0 Protein of unknown function (DUF629) Zn_Tnp_IS1595 PF12760.5 T070378_3 - 9.6 6.2 25.4 0.087 12.7 1.3 5.6 5 0 0 5 5 5 0 Transposase zinc-ribbon domain Sorb PF02208.14 T275826_1 - 4e-06 26.3 0.0 9.7e-06 25.0 0.0 1.7 1 0 0 1 1 1 1 Sorbin homologous domain SH3_1 PF00018.26 T275826_3 - 2.3e-41 139.0 0.3 3.8e-14 51.9 0.0 3.4 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.4 T275826_3 - 9.2e-38 127.7 0.8 7.2e-13 48.0 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.15 T275826_3 - 1e-27 95.4 0.6 1.3e-13 50.3 0.0 3.5 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 T275826_3 - 8.8e-12 44.4 0.7 1.9e-11 43.3 0.7 1.5 1 0 0 1 1 1 1 Sorbin homologous domain Ribosomal_L50 PF10501.7 T363894_2 - 9.3e-12 45.0 0.0 1.4e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal subunit 39S RA PF00788.21 T315615_2 - 9.3e-47 157.5 0.0 7e-23 80.9 0.0 2.8 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain DIL PF01843.17 T315615_2 - 7.9e-31 106.3 2.1 1.2e-30 105.8 0.6 2.1 2 0 0 2 2 2 1 DIL domain PDZ PF00595.22 T315615_2 - 1.8e-16 60.1 0.5 1.8e-16 60.1 0.5 1.9 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) FHA PF00498.24 T315615_2 - 6.3e-07 29.5 0.0 1.4e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 FHA domain PDZ_2 PF13180.4 T315615_2 - 0.0021 18.2 0.4 0.0057 16.8 0.4 1.7 1 0 0 1 1 1 1 PDZ domain Yop-YscD_cpl PF16697.3 T315615_2 - 0.0077 16.4 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain MGTL PF17059.3 T157505_2 - 0.057 13.1 1.2 0.19 11.5 1.2 2.0 1 0 0 1 1 1 0 MgtA leader peptide Hormone_2 PF00123.18 T157505_3 - 6.4e-20 70.7 0.6 4.4e-11 42.4 0.2 2.6 2 0 0 2 2 2 2 Peptide hormone Pardaxin PF07425.9 T098232_1 - 0.87 9.1 3.0 1.3 8.5 0.9 2.2 2 0 0 2 2 2 0 Pardaxin GGACT PF06094.10 T098232_2 - 8.6e-20 71.4 0.0 1.3e-19 70.8 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like SPRY PF00622.26 T032737_1 - 4e-11 43.0 0.0 6.3e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 T032737_1 - 1.5e-09 37.7 4.0 1.5e-09 37.7 4.0 4.2 6 0 0 6 6 6 2 B-box zinc finger fn3 PF00041.19 T032737_1 - 6.7e-08 32.6 0.0 1.3e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_UBOX PF13445.4 T032737_1 - 7.6e-06 25.7 2.5 3e-05 23.8 2.5 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 T032737_1 - 2.4e-05 23.9 1.5 2.4e-05 23.9 1.5 4.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T032737_1 - 7.7e-05 22.6 3.3 7.7e-05 22.6 3.3 3.2 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 T032737_1 - 0.00027 20.6 1.9 0.00027 20.6 1.9 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 T032737_1 - 0.00053 19.4 0.1 0.0012 18.3 0.1 1.6 1 0 0 1 1 1 1 SPRY-associated domain PHR PF08005.10 T096449_3 - 3.7e-84 280.7 0.0 1.3e-40 139.4 0.0 2.7 2 0 0 2 2 2 2 PHR domain RCC1 PF00415.16 T096449_3 - 1.8e-21 76.4 23.4 3.6e-12 46.6 1.6 6.9 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 T096449_3 - 2.8e-20 71.4 13.7 1.1e-07 31.3 0.1 5.3 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat SH3_3 PF08239.9 T096449_3 - 4.4e-15 55.6 0.3 3.7e-07 30.2 0.0 3.4 3 0 0 3 3 3 2 Bacterial SH3 domain zf-RING_2 PF13639.4 T096449_3 - 2.1e-07 30.9 6.9 2.1e-07 30.9 6.9 5.2 5 1 0 5 5 5 1 Ring finger domain Filamin PF00630.17 T096449_3 - 7.8e-06 26.5 0.0 2.1e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Filamin/ABP280 repeat ANAPC10 PF03256.14 T096449_3 - 2.7e-05 23.8 0.1 6e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) zf-RING_11 PF17123.3 T096449_3 - 0.0058 16.2 8.4 0.05 13.2 8.4 2.8 1 0 0 1 1 1 1 RING-like zinc finger RNB PF00773.17 T096079_2 - 2.3e-103 345.8 0.5 3.3e-103 345.3 0.5 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.1 T096079_2 - 3.3e-13 49.5 0.0 5.6e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.1 T096079_2 - 1.1e-11 44.4 0.3 2e-11 43.5 0.3 1.4 1 0 0 1 1 1 1 S1 domain PIN_4 PF13638.4 T096079_2 - 5.3e-06 26.6 0.1 7e-05 23.0 0.0 2.4 2 0 0 2 2 2 1 PIN domain Ten_N PF06484.10 T292772_3 - 7.2e-82 276.1 20.1 1.1e-81 275.4 20.1 1.2 1 0 0 1 1 1 1 Teneurin Intracellular Region Tox-GHH PF15636.4 T292772_3 - 6.1e-31 106.0 0.7 1.1e-30 105.2 0.7 1.5 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin EGF_2 PF07974.11 T292772_3 - 7.6e-21 74.0 159.2 0.00026 21.2 11.3 9.3 9 0 0 9 9 9 8 EGF-like domain RHS_repeat PF05593.12 T292772_3 - 2.6e-11 43.7 38.1 0.0026 18.1 4.1 9.7 8 2 4 12 12 12 4 RHS Repeat NHL PF01436.19 T292772_3 - 4.2e-09 35.9 1.1 0.011 15.6 0.0 6.1 5 0 0 5 5 5 1 NHL repeat CarboxypepD_reg PF13620.4 T292772_3 - 0.0005 20.2 0.0 0.0019 18.3 0.0 2.0 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 T292772_3 - 0.0056 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 CarboxypepD_reg-like domain DUF2283 PF10049.7 T292772_3 - 0.21 11.8 0.4 56 4.0 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2283) zf-H2C2_2 PF13465.4 T174662_3 - 6.5e-34 114.7 48.8 2.4e-06 27.6 0.5 8.9 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 T174662_3 - 5.7e-24 83.0 66.8 6.3e-05 23.1 1.4 8.4 8 0 0 8 8 8 6 Zinc finger, C2H2 type KRAB PF01352.25 T174662_3 - 7.7e-23 79.8 0.0 1.5e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T174662_3 - 2.6e-06 27.6 73.3 0.0053 17.3 4.3 9.4 9 0 0 9 9 9 6 C2H2-type zinc finger PTN_MK_N PF05196.11 T057963_1 - 2.7e-26 91.4 12.3 2.7e-26 91.4 12.3 3.2 4 0 0 4 4 4 1 PTN/MK heparin-binding protein family, N-terminal domain PTN_MK_C PF01091.16 T057963_1 - 4.5e-24 84.5 12.0 4.5e-24 84.5 12.0 2.5 2 0 0 2 2 2 1 PTN/MK heparin-binding protein family, C-terminal domain DAGK_acc PF00609.17 T057963_2 - 2.7e-46 157.7 0.0 4.1e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 T057963_2 - 7.9e-29 99.7 0.0 1.4e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 T057963_2 - 5.1e-12 45.3 26.1 7.8e-10 38.4 13.8 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_2 PF12796.5 T057963_3 - 1.3e-10 41.6 0.1 2.2e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T057963_3 - 6e-10 39.1 0.1 0.00024 21.2 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 T057963_3 - 3.6e-08 32.9 0.1 0.0086 16.4 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.4 T057963_3 - 3.7e-07 30.4 0.1 2.4e-05 24.6 0.1 2.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 T057963_3 - 8.9e-05 22.6 0.5 0.13 12.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat MR_MLE_C PF13378.4 T157448_2 - 3.9e-44 150.8 0.0 6.2e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.14 T157448_2 - 0.023 14.8 0.0 0.058 13.5 0.0 1.6 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain zf-H2C2_2 PF13465.4 T171164_1 - 1.4e-55 183.2 79.9 2.2e-07 30.9 0.6 13.3 12 0 0 12 12 12 10 Zinc-finger double domain zf-C2H2 PF00096.24 T171164_1 - 8.5e-35 117.2 54.8 3.2e-06 27.1 1.1 9.3 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T171164_1 - 2.8e-16 58.7 51.9 0.057 14.1 0.8 9.5 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T171164_1 - 3.2e-13 49.1 48.7 0.00013 21.6 1.0 8.9 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T171164_1 - 1e-07 31.4 17.5 0.54 9.9 0.0 8.2 8 0 0 8 8 8 3 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T171164_1 - 8.9e-06 25.6 39.1 0.27 11.2 2.3 6.1 2 1 5 7 7 7 6 Zinc ribbon domain XPA_N PF01286.16 T171164_1 - 0.00021 21.1 30.6 7.8 6.5 0.2 8.7 8 0 0 8 8 8 4 XPA protein N-terminal ADK_lid PF05191.12 T171164_1 - 0.26 11.2 29.0 0.5 10.3 2.5 5.0 4 0 0 4 4 4 0 Adenylate kinase, active site lid Gag_MA PF01140.17 T171164_3 - 4.5e-15 55.3 0.0 8.9e-15 54.4 0.0 1.4 1 0 0 1 1 1 1 Matrix protein (MA), p15 zf-H2C2_2 PF13465.4 T171164_3 - 9.5e-08 32.0 0.3 9.5e-08 32.0 0.3 3.6 3 0 0 3 3 3 2 Zinc-finger double domain Zn-ribbon_8 PF09723.8 T171164_3 - 0.15 12.1 7.7 0.36 10.8 1.4 2.8 2 0 0 2 2 2 0 Zinc ribbon domain O-FucT PF10250.7 T227952_3 - 7.8e-67 226.1 0.0 9.7e-67 225.8 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase TCR PF03638.13 T062453_3 - 5.4e-13 48.9 59.4 6.1e-12 45.5 23.2 4.1 3 0 0 3 3 3 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain zf-C2H2_jaz PF12171.6 T145717_3 - 0.00039 20.5 0.0 0.00081 19.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T145717_3 - 0.001 19.3 0.1 0.0023 18.2 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type UvrD_C PF13361.4 T145717_3 - 0.03 13.6 0.6 0.04 13.2 0.6 1.2 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF1178 PF06676.9 T145717_3 - 0.054 13.7 1.8 0.11 12.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) Sec34 PF04136.13 T145717_3 - 0.069 12.9 0.8 2.8 7.7 0.1 2.3 2 0 0 2 2 2 0 Sec34-like family Reo_sigmaC PF04582.10 T088377_3 - 0.43 9.8 6.5 1.3 8.3 0.8 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein KASH_CCD PF14662.4 T088377_3 - 1.4 8.6 31.6 0.19 11.4 10.2 3.3 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH DMPK_coil PF08826.8 T088377_3 - 3.2 7.8 7.6 18 5.4 0.5 3.5 2 1 1 3 3 3 0 DMPK coiled coil domain like Endosulfine PF04667.15 T020549_1 - 3.1e-08 33.5 1.7 5.9e-08 32.6 1.7 1.4 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region IN_DBD_C PF00552.19 T020549_1 - 3.3e-05 23.0 0.1 7.7e-05 21.8 0.1 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain rve PF00665.24 T020549_2 - 1.1e-25 90.0 0.1 2.4e-25 88.9 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T020549_2 - 2.6e-18 66.5 0.0 4.1e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 RNase H Integrase_Zn PF02022.17 T020549_2 - 2e-16 59.5 2.3 5.5e-16 58.1 2.3 1.8 1 0 0 1 1 1 1 Integrase Zinc binding domain RVT_thumb PF06817.12 T020549_2 - 0.00021 20.8 0.2 0.00052 19.5 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase thumb domain OTU PF02338.17 T312272_2 - 1.7e-32 112.4 0.0 3.4e-32 111.5 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease zf-A20 PF01754.14 T312272_2 - 1.4e-31 107.9 75.1 6.1e-07 29.1 8.4 8.0 7 0 0 7 7 7 7 A20-like zinc finger PDEase_I PF00233.17 T259025_2 - 1.2e-42 146.2 8.0 7.3e-26 91.2 0.3 3.2 3 0 0 3 3 3 3 3'5'-cyclic nucleotide phosphodiesterase EF-hand_1 PF00036.30 T259025_3 - 7e-11 40.7 2.0 4.9e-05 22.5 0.8 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 T259025_3 - 9.3e-11 41.9 2.3 0.00026 21.3 0.4 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 T259025_3 - 1.3e-09 37.1 2.2 1.9e-05 24.1 0.7 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 T259025_3 - 0.00019 20.7 4.0 0.015 14.7 2.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 T259025_3 - 0.00021 20.9 4.3 0.0018 17.9 0.2 3.1 1 1 2 3 3 3 1 EF-hand domain pair PDEase_I PF00233.17 T259025_3 - 0.00024 20.8 0.2 0.43 10.1 0.0 2.3 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase Collagen PF01391.16 T306239_1 - 3.6e-89 292.3 335.7 2e-09 36.9 23.0 12.1 3 3 9 12 12 12 12 Collagen triple helix repeat (20 copies) Laminin_G_2 PF02210.22 T306239_1 - 0.021 15.3 0.0 0.036 14.5 0.0 1.2 1 0 0 1 1 1 0 Laminin G domain Laminin_G_3 PF13385.4 T306239_1 - 0.093 12.7 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Peptidase_S28 PF05577.10 T064939_2 - 4.1e-96 322.3 0.0 5e-96 322.0 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Hydrolase_4 PF12146.6 T064939_2 - 0.00017 20.8 0.0 0.00027 20.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S37 PF05576.9 T064939_2 - 0.00056 18.6 0.0 0.00089 17.9 0.0 1.2 1 0 0 1 1 1 1 PS-10 peptidase S37 DUF2920 PF11144.6 T064939_2 - 0.0012 18.0 0.0 0.0018 17.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) Peptidase_S9 PF00326.19 T064939_2 - 0.0068 15.8 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.5 T064939_2 - 0.031 14.8 1.5 0.049 14.1 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 T064939_2 - 0.043 13.3 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold ADK PF00406.20 T007495_1 - 6.2e-51 172.3 0.0 9.3e-51 171.8 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.12 T007495_1 - 7.3e-16 57.8 0.0 1.9e-15 56.4 0.0 1.8 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.4 T007495_1 - 6e-14 52.5 0.0 1e-13 51.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.4 T007495_3 - 0.051 13.9 0.1 0.077 13.3 0.1 1.2 1 0 0 1 1 1 0 AAA domain ADK PF00406.20 T007495_3 - 0.11 12.5 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Adenylate kinase INT_SG_DDX_CT_C PF15300.4 T380610_2 - 5e-29 99.8 4.8 8.9e-29 98.9 4.8 1.4 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus DUF1090 PF06476.10 T380610_2 - 0.024 14.6 0.2 0.067 13.2 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) KRAB PF01352.25 T325107_3 - 5.2e-24 83.5 1.5 7.8e-24 82.9 0.2 2.0 2 0 0 2 2 2 1 KRAB box CUB PF00431.18 T039670_1 - 7.1e-58 193.6 0.0 7.9e-29 100.1 0.0 2.5 2 0 0 2 2 2 2 CUB domain F5_F8_type_C PF00754.23 T039670_1 - 2.5e-53 179.4 1.4 2.6e-26 92.1 0.9 2.3 2 0 0 2 2 2 2 F5/8 type C domain DUF3481 PF11980.6 T039670_1 - 3.8e-46 154.6 0.3 6.8e-46 153.8 0.3 1.4 1 0 0 1 1 1 1 C-terminal domain of neuropilin glycoprotein MAM PF00629.21 T039670_1 - 5.1e-41 140.1 1.0 8.2e-41 139.4 1.0 1.3 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu GTP_EFTU PF00009.25 T311835_2 - 6e-46 156.3 0.0 8.8e-46 155.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 T311835_2 - 2.7e-29 101.6 0.1 4.9e-29 100.8 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain HBS1_N PF08938.8 T311835_2 - 4.9e-17 61.9 0.3 8.8e-17 61.1 0.3 1.3 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D2 PF03144.23 T311835_2 - 6e-07 29.6 0.0 1.1e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 T311835_2 - 0.00088 19.2 0.1 0.0074 16.2 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Aldedh PF00171.20 T311835_3 - 7.1e-159 529.1 0.0 9.3e-159 528.7 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family UQ_con PF00179.24 T278444_2 - 1.3e-10 40.9 0.0 3.1e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Pyridoxal_deC PF00282.17 T043512_1 - 1.3e-16 60.2 0.0 2.1e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 T043512_1 - 8.4e-12 44.6 0.0 1.9e-11 43.4 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.19 T043512_1 - 5.4e-07 29.0 0.0 1.4e-06 27.6 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II SepSecS PF05889.11 T043512_1 - 0.017 13.7 0.0 0.027 13.0 0.0 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Copine PF07002.14 T302684_2 - 3.2e-90 301.2 0.0 4.2e-90 300.8 0.0 1.1 1 0 0 1 1 1 1 Copine C2 PF00168.28 T302684_2 - 3.3e-29 101.1 0.1 1.3e-13 51.0 0.0 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 T302684_2 - 7.1e-06 26.1 0.0 1.1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VCBS PF13517.4 T302684_2 - 0.16 12.5 0.2 0.43 11.1 0.2 1.7 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella ILEI PF15711.3 T244233_1 - 1.5e-27 95.8 0.0 2.5e-27 95.0 0.0 1.4 1 0 0 1 1 1 1 Interleukin-like EMT inducer DUF2228 PF10228.7 T274277_1 - 8.2e-114 379.4 0.2 9.9e-114 379.1 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2228) Peptidase_C70 PF12385.6 T274277_1 - 0.025 14.4 0.0 0.046 13.6 0.0 1.3 1 0 0 1 1 1 0 Papain-like cysteine protease AvrRpt2 DUF2151 PF10221.7 T075679_3 - 1.3e-288 959.2 4.5 1.5e-288 958.9 4.5 1.0 1 0 0 1 1 1 1 Cell cycle and development regulator GRIN_C PF15235.4 T041215_3 - 1e-24 87.1 0.0 2.3e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 G protein-regulated inducer of neurite outgrowth C-terminus Toxin_18 PF08087.9 T329114_1 - 0.052 13.4 2.9 0.12 12.3 2.9 1.6 1 0 0 1 1 1 0 Conotoxin O-superfamily Transglut_C PF00927.20 T115430_1 - 6e-50 167.7 0.1 5.7e-26 90.6 0.1 2.9 3 0 0 3 3 3 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.18 T115430_1 - 1.4e-30 106.0 0.0 1.1e-29 103.1 0.0 2.2 2 0 0 2 2 2 1 Transglutaminase family Transglut_core PF01841.17 T115430_1 - 3.1e-18 66.1 0.5 5.8e-18 65.2 0.5 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily BLOC1S3 PF15753.3 T177227_2 - 1.4e-42 145.6 0.0 1.8e-42 145.2 0.0 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex 1 subunit 3 MRFAP1 PF15155.4 T260545_2 - 4.2e-55 185.3 7.4 6.8e-55 184.6 7.4 1.3 1 0 0 1 1 1 1 MORF4 family-associated protein1 L27 PF02828.14 T083056_1 - 2e-13 49.7 0.0 3.7e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 L27 domain PDZ PF00595.22 T083056_3 - 3e-19 69.0 0.4 4.6e-19 68.4 0.4 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T083056_3 - 0.019 15.1 0.0 0.035 14.3 0.0 1.3 1 0 0 1 1 1 0 PDZ domain 7TMR-HDED PF07697.9 T083056_3 - 1.5 8.7 6.2 2.4 8.1 6.2 1.1 1 0 0 1 1 1 0 7TM-HD extracellular DUF972 PF06156.11 T354215_2 - 0.1 13.1 0.8 0.18 12.3 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Kinesin PF00225.21 T354215_3 - 2.1e-89 299.6 0.0 2.9e-89 299.2 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 T354215_3 - 7.9e-34 116.6 0.0 1.1e-33 116.1 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding MH2 PF03166.12 T118394_1 - 1.2e-53 181.9 0.0 1.7e-53 181.4 0.0 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 T118394_1 - 1.8e-26 92.2 0.0 3.1e-26 91.4 0.0 1.4 1 0 0 1 1 1 1 MH1 domain LEM PF03020.13 T028846_1 - 1.2e-06 27.8 0.0 2.4e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 LEM domain CLTH PF10607.7 T222114_1 - 6.9e-32 110.2 4.5 6.9e-32 110.2 4.5 1.5 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain MFS_1 PF07690.14 T222114_1 - 2.3e-22 79.3 6.9 3.6e-22 78.6 6.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily LisH PF08513.9 T222114_1 - 1.4e-09 37.4 0.7 3.3e-09 36.3 0.1 2.0 3 0 0 3 3 3 1 LisH MFS_1 PF07690.14 T222114_3 - 1.3e-12 47.2 14.6 1.9e-08 33.5 4.8 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4200 PF13863.4 T249760_2 - 1.4e-32 112.4 15.0 1.4e-32 112.4 15.0 4.7 4 0 0 4 4 4 2 Domain of unknown function (DUF4200) DNA_photolyase PF00875.16 T249760_2 - 0.78 9.6 5.8 0.49 10.3 0.7 2.5 2 0 0 2 2 2 0 DNA photolyase TMEM210 PF15195.4 T369950_1 - 4.7e-62 207.3 0.7 8.9e-62 206.4 0.7 1.4 1 0 0 1 1 1 1 TMEM210 family Cullin PF00888.20 T369950_2 - 1.6e-30 106.2 0.1 2.8e-30 105.4 0.0 1.3 2 0 0 2 2 2 1 Cullin family ANAPC2 PF08672.9 T369950_2 - 2e-20 72.9 0.5 4e-20 71.9 0.5 1.5 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 LRR_8 PF13855.4 T369950_3 - 5e-27 93.3 1.8 1.6e-14 53.2 0.1 2.5 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 T369950_3 - 3.3e-08 33.5 1.4 0.0023 18.2 0.2 3.3 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 T369950_3 - 0.00075 18.9 0.0 0.0019 17.6 0.0 1.5 1 1 1 2 2 2 1 Leucine-rich repeat TBCA PF02970.14 T284669_3 - 9.7e-32 109.0 14.1 1.2e-31 108.7 14.1 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor A Bromodomain PF00439.23 T201753_1 - 1.2e-20 73.2 0.0 2.8e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain MBD PF01429.17 T201753_1 - 2.7e-20 71.7 0.0 5.9e-20 70.6 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain PHD PF00628.27 T201753_1 - 2.4e-11 43.2 9.2 7.1e-11 41.7 9.2 1.9 1 0 0 1 1 1 1 PHD-finger WSD PF15613.4 T201753_1 - 9.7e-11 41.9 0.1 4.7e-07 30.1 0.1 4.8 5 0 0 5 5 5 2 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.15 T201753_1 - 6.2e-09 35.9 0.3 1.3e-08 34.8 0.3 1.6 1 0 0 1 1 1 1 DDT domain PUFD PF16553.3 T379971_3 - 1.4e-50 170.1 0.0 2.4e-50 169.3 0.0 1.4 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain Ank_2 PF12796.5 T379971_3 - 6.7e-13 48.9 0.4 5.8e-12 45.9 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T379971_3 - 4.4e-10 38.8 0.2 4.8e-05 23.3 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 T379971_3 - 5.2e-10 39.5 0.5 1.7e-05 25.1 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 T379971_3 - 1.3e-09 38.0 3.3 3.1e-06 27.3 0.3 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 T379971_3 - 3.9e-08 33.3 0.6 9.4e-05 22.6 0.1 3.5 2 1 1 3 3 3 1 Ankyrin repeat DnaJ PF00226.29 T043759_1 - 1.1e-25 89.3 0.2 1.9e-25 88.6 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.9 T043759_1 - 1.5e-25 89.3 0.0 2.5e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) zf-FCS PF06467.12 T090927_3 - 5.5e-67 221.3 117.1 3.5e-10 39.5 4.1 11.1 10 0 0 10 10 10 10 MYM-type Zinc finger with FCS sequence motif DUF3504 PF12012.6 T090927_3 - 2.7e-62 209.3 1.8 5.8e-62 208.2 1.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) Arc_trans_TRASH PF08394.8 T090927_3 - 0.0034 17.5 5.6 0.0034 17.5 5.6 6.1 6 0 0 6 6 6 1 Archaeal TRASH domain YHS PF04945.11 T090927_3 - 0.011 15.6 0.2 0.011 15.6 0.2 8.5 9 0 0 9 9 9 0 YHS domain NosL PF05573.10 T090927_3 - 0.39 10.7 1.9 9.7 6.2 0.1 3.0 2 1 1 3 3 3 0 NosL Bromodomain PF00439.23 T035182_1 - 1.2e-09 38.0 0.1 2.6e-09 36.9 0.1 1.5 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.15 T035182_1 - 3e-09 37.1 0.4 3e-09 37.1 0.4 2.3 2 1 0 2 2 2 1 PWWP domain DUF4224 PF13986.4 T326615_2 - 0.12 12.2 0.1 0.32 10.8 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4224) zf-C2H2 PF00096.24 T133378_2 - 9e-52 170.6 132.5 7.9e-06 25.9 0.9 17.2 17 0 0 17 17 17 14 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T133378_2 - 5.4e-46 152.9 131.2 2.9e-11 43.1 1.2 16.9 16 0 0 16 16 16 11 Zinc-finger double domain zf-C2H2_4 PF13894.4 T133378_2 - 1.1e-32 109.7 128.9 0.0041 17.7 0.8 17.4 18 0 0 18 18 18 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T133378_2 - 2.8e-19 68.8 75.6 0.0047 17.1 0.1 15.1 16 0 0 16 16 16 11 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T133378_2 - 3.1e-11 43.2 85.1 0.02 15.1 0.2 14.5 14 0 0 14 14 14 8 Zinc-finger of C2H2 type zf-Di19 PF05605.10 T133378_2 - 1.4e-05 25.1 87.5 0.0053 16.9 3.3 10.2 6 3 3 10 10 10 7 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 T133378_2 - 0.0046 16.7 0.3 0.0046 16.7 0.3 15.3 16 0 0 16 16 16 6 C2H2-type zinc finger BolA PF01722.16 T133378_2 - 5.6 7.2 29.0 21 5.4 0.1 7.8 5 3 1 8 8 8 0 BolA-like protein Trypsin PF00089.24 T223935_3 - 5.8e-71 238.7 0.0 8.4e-71 238.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 T223935_3 - 1e-47 160.9 0.0 2.7e-25 88.7 0.0 2.5 2 0 0 2 2 2 2 CUB domain MAM PF00629.21 T223935_3 - 1.5e-40 138.5 0.0 2.5e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu SEA PF01390.18 T223935_3 - 1.3e-17 63.8 1.3 2.6e-17 62.9 1.3 1.5 1 0 0 1 1 1 1 SEA domain Ldl_recept_a PF00057.16 T223935_3 - 8.4e-16 57.8 23.7 5.1e-10 39.3 8.9 2.7 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF1986 PF09342.9 T223935_3 - 2.2e-08 34.3 0.0 4.8e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SRCR_2 PF15494.4 T223935_3 - 1.2e-07 32.1 0.1 2.4e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR PF00530.16 T223935_3 - 1.7e-06 28.3 0.5 6.7e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain XFP_C PF09363.8 T223935_3 - 0.026 13.9 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 XFP C-terminal domain zf-H2C2_2 PF13465.4 T354487_1 - 3.4e-201 643.5 188.1 4.8e-08 33.0 0.8 31.5 31 0 0 31 31 31 28 Zinc-finger double domain zf-C2H2 PF00096.24 T354487_1 - 4.1e-140 448.9 221.1 3.5e-06 27.0 0.4 31.4 30 0 0 30 30 30 29 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T354487_1 - 4.9e-57 185.5 225.5 0.016 15.8 0.4 31.4 31 0 0 31 31 31 28 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T354487_1 - 5.5e-22 77.1 177.9 0.01 15.6 1.0 28.1 30 0 0 30 30 30 20 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T354487_1 - 5.7e-22 77.4 129.9 0.012 15.6 1.8 17.9 9 4 8 19 19 19 18 Zinc ribbon domain KRAB PF01352.25 T354487_1 - 1.6e-18 65.9 0.1 3.1e-18 65.0 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 T354487_1 - 6.8e-08 32.5 115.6 0.28 11.4 0.1 26.4 29 0 0 29 29 29 6 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T354487_1 - 2.8e-05 24.6 108.3 2.3 8.9 4.4 14.7 2 2 16 18 18 18 6 zinc-ribbon family XPA_N PF01286.16 T354487_1 - 0.047 13.6 111.7 12 5.9 0.0 27.5 30 0 0 30 30 30 0 XPA protein N-terminal COMM_domain PF07258.12 T354487_2 - 3e-14 52.7 0.0 7e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 COMM domain Cadherin PF00028.15 T016809_2 - 2.3e-173 563.1 13.7 1.4e-22 79.8 0.0 9.4 9 0 0 9 9 9 9 Cadherin domain GAIN PF16489.3 T016809_2 - 1.2e-61 207.7 0.0 2e-61 206.9 0.0 1.4 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Laminin_G_2 PF02210.22 T016809_2 - 1.9e-45 154.4 0.3 7.8e-26 91.0 0.0 2.7 2 0 0 2 2 2 2 Laminin G domain 7tm_2 PF00002.22 T016809_2 - 2.9e-43 147.8 7.7 4e-43 147.3 7.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Laminin_G_1 PF00054.21 T016809_2 - 1.8e-23 83.0 0.1 6.2e-14 52.2 0.0 3.4 2 1 0 2 2 2 2 Laminin G domain GPS PF01825.19 T016809_2 - 2.2e-15 56.9 3.4 2.2e-15 56.9 3.4 2.7 2 0 0 2 2 1 1 GPCR proteolysis site, GPS, motif EGF PF00008.25 T016809_2 - 1.7e-13 50.5 118.0 1e-07 32.0 7.8 9.1 10 0 0 10 10 9 6 EGF-like domain Cadherin_3 PF16184.3 T016809_2 - 1.4e-11 44.3 11.0 0.014 15.2 0.2 7.7 8 0 0 8 8 8 2 Cadherin-like Laminin_EGF PF00053.22 T016809_2 - 5.6e-09 35.9 12.5 5.6e-09 35.9 12.5 8.7 6 2 2 8 8 8 2 Laminin EGF domain Cadherin_2 PF08266.10 T016809_2 - 1.4e-07 31.1 0.1 0.89 9.3 0.0 6.6 8 0 0 8 8 8 1 Cadherin-like hEGF PF12661.5 T016809_2 - 3.6e-06 27.3 90.5 0.00086 19.8 6.8 8.8 8 0 0 8 8 7 5 Human growth factor-like EGF Cadherin_pro PF08758.9 T016809_2 - 6e-06 26.2 0.0 0.21 11.7 0.0 4.6 5 0 0 5 5 4 1 Cadherin prodomain like Dicty_CAR PF05462.9 T016809_2 - 0.0099 14.9 2.0 0.016 14.2 2.0 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor EGF_CA PF07645.13 T016809_2 - 4.6 7.4 90.3 0.24 11.5 4.9 7.8 3 2 5 8 8 5 0 Calcium-binding EGF domain Thyroglobulin_1 PF00086.16 T207334_1 - 6.1e-18 64.1 2.5 6.1e-18 64.1 2.5 1.7 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat 7tm_3 PF00003.20 T294808_1 - 3.6e-57 193.7 8.6 8.2e-57 192.5 8.6 1.6 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 T294808_1 - 6.4e-23 81.3 0.0 9.2e-23 80.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 T294808_1 - 1.7e-13 50.2 10.0 6.5e-13 48.3 10.0 2.1 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF3368 PF11848.6 T294808_1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3368) C2 PF00168.28 T349090_2 - 1.1e-36 125.1 0.0 5.1e-19 68.3 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 T349090_2 - 6.3e-15 55.3 13.2 1.3e-14 54.3 13.2 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger PDZ PF00595.22 T349090_2 - 1.3e-05 25.3 0.0 2.5e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DRMBL PF07522.12 T037578_3 - 4.2e-06 26.9 0.0 9e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase C2 PF00168.28 T207726_1 - 4.7e-15 55.6 0.0 7.1e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 C2 domain PI-PLC-X PF00388.17 T207726_2 - 1.6e-64 215.8 0.0 2.3e-64 215.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain EF-hand_like PF09279.9 T207726_2 - 2.3e-34 117.6 0.2 2.3e-34 117.6 0.2 1.9 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_10 PF14788.4 T207726_2 - 4.2e-23 80.8 0.5 9e-23 79.8 0.5 1.6 1 0 0 1 1 1 1 EF hand PI-PLC-Y PF00387.17 T207726_2 - 3.5e-17 62.7 0.2 3.7e-09 36.8 0.0 2.4 2 0 0 2 2 2 2 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_7 PF13499.4 T207726_2 - 5.7e-08 33.0 3.9 5.6e-06 26.6 0.3 3.0 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.30 T207726_2 - 6.2e-08 31.5 0.1 0.0047 16.3 0.0 2.8 2 0 0 2 2 2 2 EF hand PH PF00169.27 T207726_2 - 7.1e-07 29.6 0.0 1.5e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 PH domain EF-hand_5 PF13202.4 T207726_2 - 8.6e-07 28.1 0.3 0.0027 17.0 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T207726_2 - 1.2e-06 27.9 2.5 0.084 12.7 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain GDPD PF03009.15 T207726_2 - 0.00066 19.4 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family EF-hand_8 PF13833.4 T207726_2 - 0.0086 15.7 0.5 0.019 14.6 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain pair PH_12 PF16457.3 T207726_2 - 0.0093 16.4 0.0 0.021 15.2 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Wap1 PF16997.3 T207726_2 - 0.037 13.0 0.1 0.058 12.4 0.1 1.2 1 0 0 1 1 1 0 Wap1 domain PI-PLC-Y PF00387.17 T207726_3 - 3.2e-13 49.9 0.0 6.1e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain ADIP PF11559.6 T080649_1 - 0.044 13.8 7.6 0.066 13.2 7.6 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.7 T080649_1 - 0.13 12.1 2.9 0.2 11.5 2.9 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cnn_1N PF07989.9 T080649_1 - 0.17 11.9 2.5 0.27 11.3 2.5 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 TPR_MLP1_2 PF07926.10 T080649_1 - 0.38 10.7 4.4 0.61 10.0 4.4 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein SHE3 PF17078.3 T080649_1 - 0.4 10.2 1.9 0.61 9.6 1.9 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Spc7 PF08317.9 T080649_1 - 0.55 8.9 6.9 0.8 8.4 6.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein IncA PF04156.12 T080649_1 - 0.94 9.1 6.1 1.6 8.4 6.1 1.2 1 0 0 1 1 1 0 IncA protein RhoGEF PF00621.18 T080649_2 - 3.6e-36 125.0 0.2 5.1e-36 124.5 0.2 1.2 1 0 0 1 1 1 1 RhoGEF domain STAS PF01740.19 T080649_2 - 2.3e-16 59.3 0.0 3.7e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 STAS domain zf-C3HC4_2 PF13923.4 T080649_2 - 1.7e-10 40.4 9.3 1.7e-10 40.4 9.3 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T080649_2 - 1.4e-07 31.5 7.3 1.4e-07 31.5 7.3 3.8 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4 PF00097.23 T080649_2 - 9.7e-07 28.4 10.0 9.7e-07 28.4 10.0 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T080649_2 - 4.2e-06 26.4 6.3 4.2e-06 26.4 6.3 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T080649_2 - 7.6e-05 22.5 5.5 7.6e-05 22.5 5.5 3.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.5 T080649_2 - 0.00016 21.7 5.1 0.00066 19.8 5.1 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-Nse PF11789.6 T080649_2 - 0.0047 16.6 4.0 0.013 15.2 4.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit STAS_2 PF13466.4 T080649_2 - 0.0093 16.2 4.1 0.027 14.7 4.1 1.7 1 0 0 1 1 1 1 STAS domain zf-RING_10 PF16685.3 T080649_2 - 0.17 11.9 3.9 0.51 10.4 3.9 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 Kinesin PF00225.21 T080649_3 - 1.1e-109 366.3 0.1 1.8e-109 365.6 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Sulfate_transp PF00916.18 T080649_3 - 3.4e-89 299.1 13.7 3.7e-75 252.9 8.6 2.2 2 0 0 2 2 2 2 Sulfate permease family PIP5K PF01504.16 T080649_3 - 9.4e-68 228.3 0.0 1.7e-67 227.4 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Microtub_bd PF16796.3 T080649_3 - 1.6e-24 86.4 0.0 3e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding Jiraiya PF15038.4 T120926_1 - 0.13 11.6 0.7 0.22 10.8 0.7 1.2 1 0 0 1 1 1 0 Jiraiya SPRY PF00622.26 T120926_2 - 2.3e-08 34.0 0.0 4.5e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 SPRY domain fn3 PF00041.19 T120926_2 - 2.1e-06 27.8 1.5 0.0014 18.8 0.1 2.4 1 1 1 2 2 2 2 Fibronectin type III domain PRY PF13765.4 T120926_2 - 3e-05 23.4 0.1 7.2e-05 22.2 0.1 1.7 1 0 0 1 1 1 1 SPRY-associated domain Apolipoprotein PF01442.16 T120926_2 - 0.058 13.2 2.7 0.095 12.5 2.7 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Fumerase_C PF05683.10 T120926_2 - 0.14 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Fumarase C-terminus DUF5082 PF16888.3 T120926_2 - 0.27 11.5 4.4 0.73 10.1 4.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF3552 PF12072.6 T120926_2 - 1.2 8.4 10.0 1.9 7.7 10.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) OmpH PF03938.12 T120926_2 - 2.8 7.8 7.1 6.2 6.7 7.1 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) IQ_SEC7_PH PF16453.3 T375010_3 - 7.6e-61 204.0 0.2 1.5e-60 203.0 0.2 1.5 1 0 0 1 1 1 1 PH domain Sec7 PF01369.18 T375010_3 - 2.5e-55 186.9 0.0 3.5e-55 186.4 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain zf-RING_2 PF13639.4 T294083_2 - 2.9e-13 49.7 6.5 1.2e-12 47.8 6.5 2.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.5 T294083_2 - 7.2e-09 35.7 6.0 2.2e-08 34.1 6.0 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 T294083_2 - 2.3e-08 33.6 5.9 7.2e-08 32.0 5.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 T294083_2 - 9.6e-08 31.5 3.1 9.6e-08 31.5 3.1 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.23 T294083_2 - 1e-07 31.6 5.3 1e-07 31.6 5.3 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T294083_2 - 1.3e-06 28.1 4.3 4.6e-06 26.4 4.3 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 T294083_2 - 2.5e-06 27.1 3.6 2.5e-06 27.1 3.6 3.0 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T294083_2 - 0.00035 20.4 2.9 0.00035 20.4 2.9 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 T294083_2 - 0.00062 19.6 1.3 0.0025 17.7 1.3 2.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.5 T294083_2 - 0.56 10.2 5.7 1.6 8.8 5.7 1.8 1 0 0 1 1 1 0 RING-variant domain PNMA PF14893.4 T382052_3 - 1.3e-131 438.8 0.7 1.9e-131 438.2 0.7 1.2 1 0 0 1 1 1 1 PNMA zf-CCHC PF00098.21 T382052_3 - 0.021 14.7 2.8 0.076 13.0 2.8 2.0 1 0 0 1 1 1 0 Zinc knuckle Transposase_22 PF02994.12 T085562_1 - 2.8e-14 52.6 26.5 3.9e-09 35.7 15.8 2.3 2 0 0 2 2 2 2 L1 transposable element CENP-B_N PF04218.11 T085562_1 - 3.7e-05 23.1 1.0 7e-05 22.2 1.0 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Exo_endo_phos PF03372.21 T085562_1 - 0.082 13.0 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T085562_2 - 3.1e-114 381.5 14.1 5.6e-82 275.4 8.7 3.2 3 0 0 3 3 3 3 L1 transposable element Aldedh PF00171.20 T085562_2 - 7.9e-105 350.9 0.0 9.8e-105 350.6 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RVT_1 PF00078.25 T085562_2 - 8.6e-32 110.3 1.3 1.5e-31 109.5 1.3 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Formyl_trans_C PF02911.16 T085562_2 - 4.7e-15 55.5 0.0 1e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain PP-binding PF00550.23 T085562_2 - 0.0021 18.3 0.0 0.0037 17.4 0.0 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF1725 PF08333.9 T085562_2 - 0.16 11.5 0.2 0.33 10.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Aldedh PF00171.20 T085562_3 - 4.3e-51 173.7 0.2 5.9e-51 173.3 0.2 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Formyl_trans_N PF00551.17 T085562_3 - 8.8e-42 142.7 0.0 1.6e-41 141.9 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase Exo_endo_phos_2 PF14529.4 T085562_3 - 9.2e-05 22.1 3.8 0.00014 21.6 2.1 2.0 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase zf-H2C2_2 PF13465.4 T182422_2 - 1.5e-79 259.0 84.8 8.6e-09 35.3 0.7 15.6 14 1 1 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 T182422_2 - 1.2e-60 198.6 88.3 3.4e-05 23.9 1.2 15.3 14 0 0 14 14 14 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T182422_2 - 6.7e-26 88.6 101.9 0.011 16.4 0.7 16.0 15 0 0 15 15 15 13 C2H2-type zinc finger Ig_2 PF13895.4 T182422_2 - 2.8e-08 33.9 0.8 0.0001 22.4 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain zf-C2H2_jaz PF12171.6 T182422_2 - 5.1e-06 26.5 28.8 1.3 9.3 0.0 9.9 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T182422_2 - 0.00015 21.5 77.6 0.045 13.6 0.2 13.7 14 0 0 14 14 14 6 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T182422_2 - 0.3 11.7 34.5 3.3 8.4 0.2 7.0 3 2 3 6 6 6 0 zinc-ribbon family DUF3268 PF11672.6 T182422_2 - 2.3 8.5 22.5 0.49 10.6 0.4 5.9 5 1 1 6 6 6 0 zinc-finger-containing domain Zn-ribbon_8 PF09723.8 T182422_2 - 3 7.9 73.7 0.065 13.2 1.0 9.6 6 2 5 11 11 11 0 Zinc ribbon domain SCAN PF02023.15 T182422_3 - 9.9e-28 95.7 0.4 1.8e-27 94.8 0.4 1.4 1 0 0 1 1 1 1 SCAN domain Ig_2 PF13895.4 T182422_3 - 8.8e-20 70.7 0.0 5.1e-14 52.2 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 T182422_3 - 6.2e-07 29.8 0.0 0.031 14.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 T182422_3 - 0.00087 19.3 0.0 1.6 8.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Tet_JBP PF12851.5 T269058_1 - 4.1e-152 506.2 5.7 4.1e-152 506.2 5.7 2.5 2 2 1 3 3 3 1 Oxygenase domain of the 2OGFeDO superfamily DUF4187 PF13821.4 T269058_2 - 5.6 6.7 5.8 12 5.6 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4187) Ig_3 PF13927.4 T248265_2 - 1.7e-49 166.2 4.1 1.1e-13 51.5 0.0 5.6 6 0 0 6 6 6 4 Immunoglobulin domain I-set PF07679.14 T248265_2 - 2.2e-46 155.7 0.0 6.1e-16 58.1 0.0 4.7 5 0 0 5 5 4 4 Immunoglobulin I-set domain Ig_2 PF13895.4 T248265_2 - 1.2e-36 124.8 0.5 3.4e-10 40.0 0.0 4.9 5 0 0 5 5 5 4 Immunoglobulin domain fn3 PF00041.19 T248265_2 - 5.3e-34 116.3 2.5 3.4e-13 49.6 0.0 3.7 3 0 0 3 3 3 3 Fibronectin type III domain ig PF00047.23 T248265_2 - 3.2e-31 107.2 9.9 6e-09 35.8 0.0 6.5 7 0 0 7 7 6 4 Immunoglobulin domain ISET-FN3_linker PF16625.3 T248265_2 - 3e-26 91.6 12.2 3e-26 91.6 12.2 3.9 4 0 0 4 4 3 1 Unstructured linking region I-set and fnIII on Brother of CDO V-set PF07686.15 T248265_2 - 9.3e-12 45.0 8.5 0.035 14.1 0.1 9.0 6 3 0 6 6 6 3 Immunoglobulin V-set domain C1-set PF07654.13 T248265_2 - 4.3e-08 33.4 0.4 0.1 13.0 0.1 4.2 4 0 0 4 4 4 2 Immunoglobulin C1-set domain Ig_5 PF16681.3 T248265_2 - 7.1e-07 29.4 0.0 0.2 12.0 0.0 4.6 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pur_ac_phosph_N PF16656.3 T248265_2 - 1.5e-06 28.6 0.4 0.082 13.3 0.0 4.0 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.10 T248265_2 - 2.4e-06 27.4 8.4 0.026 14.5 0.0 4.6 5 0 0 5 5 4 3 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 T248265_2 - 0.00012 22.2 0.0 2.9 8.2 0.0 4.8 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 T248265_2 - 0.002 18.0 0.0 0.99 9.4 0.0 3.6 4 0 0 4 4 3 1 Izumo-like Immunoglobulin domain Y_Y_Y PF07495.11 T248265_2 - 0.038 13.8 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 Y_Y_Y domain AA_permease PF00324.19 T329855_2 - 4.9e-117 391.3 28.4 6e-117 391.0 28.4 1.1 1 0 0 1 1 1 1 Amino acid permease ARS2 PF04959.11 T329855_2 - 2.2e-90 302.1 0.7 4.6e-90 301.1 0.7 1.6 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF3546 PF12066.6 T329855_2 - 1.6e-40 137.7 0.4 3.6e-40 136.5 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) SLC12 PF03522.13 T329855_2 - 6.6e-18 64.8 10.0 3.9e-10 39.2 0.0 4.2 4 0 0 4 4 4 3 Solute carrier family 12 RRM_1 PF00076.20 T329855_2 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.7 T329855_2 - 0.86 7.9 6.7 1.3 7.4 6.7 1.1 1 0 0 1 1 1 0 Transmembrane protein LIM PF00412.20 T329855_3 - 1.3e-27 95.7 26.2 4e-12 46.0 1.4 3.9 4 0 0 4 4 4 3 LIM domain PRIMA1 PF16101.3 T231112_2 - 0.47 10.4 4.5 0.61 10.0 4.5 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.17 T231112_2 - 1.7 7.9 7.7 2.2 7.6 7.7 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal TACC PF05010.12 T049844_1 - 3.2e-07 30.2 1.0 4.9e-07 29.6 1.0 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) TACC PF05010.12 T049844_2 - 6.8e-71 238.1 26.9 8.6e-71 237.7 26.9 1.1 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) Skp1_POZ PF03931.13 T049844_2 - 0.081 13.0 0.2 0.17 11.9 0.2 1.5 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain DUF3584 PF12128.6 T049844_2 - 0.19 9.1 19.4 0.24 8.8 19.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3510 PF12022.6 T049844_2 - 2.1 8.6 9.3 35 4.7 9.3 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3510) IncA PF04156.12 T049844_2 - 9.8 5.8 28.5 4.1 7.0 14.3 2.2 1 1 1 2 2 2 0 IncA protein fn3 PF00041.19 T203796_1 - 0 2728.4 163.4 8.4e-18 64.4 0.1 57.7 57 0 0 57 57 57 57 Fibronectin type III domain I-set PF07679.14 T203796_1 - 0 1049.7 34.8 7.4e-18 64.3 0.0 28.5 31 0 0 31 31 27 22 Immunoglobulin I-set domain Ig_3 PF13927.4 T203796_1 - 1.8e-192 624.4 0.0 1.2e-08 35.3 0.1 25.5 24 0 0 24 24 23 22 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 T203796_1 - 1.7e-92 304.0 122.6 0.041 14.3 0.0 53.5 54 2 0 54 54 54 24 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 T203796_1 - 4.8e-87 286.1 0.0 0.0006 19.8 0.0 45.8 51 0 0 51 51 51 12 Fibronectin type III domain Ig_2 PF13895.4 T203796_1 - 1.2e-86 285.0 0.0 0.0027 17.9 0.0 22.7 22 0 0 22 22 22 20 Immunoglobulin domain ig PF00047.23 T203796_1 - 1.1e-82 272.1 0.9 0.00011 22.2 0.1 22.2 22 0 0 22 22 22 16 Immunoglobulin domain C2-set_2 PF08205.10 T203796_1 - 6.3e-32 109.4 21.8 0.09 12.7 0.1 19.3 20 0 0 20 20 20 8 CD80-like C2-set immunoglobulin domain DUF2369 PF10179.7 T203796_1 - 5.9e-28 97.1 5.0 0.22 11.9 0.0 22.2 26 0 0 26 26 23 3 Uncharacterised conserved protein (DUF2369) fn3_4 PF16794.3 T203796_1 - 1.1e-27 95.8 0.0 0.89 9.4 0.0 24.0 29 0 0 29 29 25 5 Fibronectin-III type domain Tissue_fac PF01108.15 T203796_1 - 2.6e-26 91.4 49.5 0.087 12.5 0.0 27.4 33 0 0 33 33 33 6 Tissue factor Receptor_2B4 PF11465.6 T203796_1 - 4.8e-26 90.9 22.6 0.33 11.1 0.0 22.9 26 1 1 27 27 25 4 Natural killer cell receptor 2B4 V-set PF07686.15 T203796_1 - 1.7e-16 60.2 11.8 1.5 8.8 0.0 16.2 17 2 0 17 17 16 3 Immunoglobulin V-set domain SusE PF14292.4 T203796_1 - 8.6e-15 55.0 44.3 12 6.2 0.0 25.0 28 1 3 31 31 28 0 SusE outer membrane protein DUF11 PF01345.16 T203796_1 - 0.00053 20.1 54.4 2 8.7 0.6 15.0 16 1 0 16 16 14 2 Domain of unknown function DUF11 DUF4493 PF14900.4 T203796_1 - 0.045 13.7 14.8 8 6.3 0.0 9.9 10 0 0 10 10 10 0 Domain of unknown function (DUF4493) fn3 PF00041.19 T203796_2 - 1.7e-49 165.9 2.5 3.4e-15 56.0 0.1 4.5 4 0 0 4 4 4 4 Fibronectin type III domain I-set PF07679.14 T203796_2 - 7.6e-29 99.5 0.0 5.6e-13 48.7 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 T203796_2 - 2.6e-16 59.9 0.0 2.5e-07 31.1 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 T203796_2 - 2.5e-08 33.8 0.0 0.00046 20.2 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain fn3 PF00041.19 T203796_3 - 9.1e-252 814.2 45.1 3.8e-18 65.5 0.2 18.4 18 0 0 18 18 18 18 Fibronectin type III domain I-set PF07679.14 T203796_3 - 1.2e-101 332.8 10.1 8e-21 73.8 0.0 9.0 9 0 0 9 9 9 7 Immunoglobulin I-set domain Ig_3 PF13927.4 T203796_3 - 2.7e-57 191.2 0.6 1.8e-11 44.3 0.0 8.4 8 0 0 8 8 8 7 Immunoglobulin domain ig PF00047.23 T203796_3 - 1.7e-29 101.7 6.0 2e-10 40.6 0.1 6.7 6 0 0 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.4 T203796_3 - 3.6e-29 100.8 0.2 1.8e-06 28.0 0.0 7.4 7 0 0 7 7 7 6 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 T203796_3 - 8.2e-21 74.2 32.5 0.23 11.9 1.2 15.1 16 0 0 16 16 16 5 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 T203796_3 - 5.3e-19 68.0 0.0 0.015 15.3 0.0 11.5 12 0 0 12 12 12 3 Fibronectin type III domain DUF11 PF01345.16 T203796_3 - 0.0059 16.7 0.0 0.51 10.5 0.0 4.0 5 1 0 5 5 5 1 Domain of unknown function DUF11 Ion_trans PF00520.29 T202285_1 - 9.4e-22 77.3 0.7 9.4e-22 77.3 0.7 2.0 2 0 0 2 2 2 1 Ion transport protein Ion_trans PF00520.29 T202285_2 - 2e-219 724.7 96.2 1.1e-64 217.9 22.9 4.4 4 0 0 4 4 4 4 Ion transport protein Na_trans_cytopl PF11933.6 T202285_2 - 4.4e-79 265.1 13.4 8.2e-79 264.2 13.4 1.4 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.11 T202285_2 - 1.6e-60 204.5 3.7 1.6e-60 204.5 3.7 2.8 3 0 0 3 3 3 1 Sodium ion transport-associated PKD_channel PF08016.10 T202285_2 - 3.5e-08 32.4 69.1 0.00018 20.2 0.1 8.5 5 3 3 8 8 8 6 Polycystin cation channel GPHH PF16905.3 T202285_2 - 1.2e-05 24.9 0.0 2.7e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated ATP-synt_B PF00430.16 T202285_2 - 0.00079 19.4 4.7 0.00079 19.4 4.7 2.3 2 0 0 2 2 2 1 ATP synthase B/B' CF(0) IQ PF00612.25 T202285_2 - 0.0041 16.7 1.0 0.012 15.2 1.0 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif Kinesin PF00225.21 T186383_2 - 2.8e-111 371.5 0.0 7.5e-76 255.1 0.0 2.2 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.3 T186383_2 - 1.3e-26 93.2 0.0 3.3e-26 91.9 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.3 T186383_2 - 0.0031 17.6 3.3 0.0071 16.4 3.3 1.5 1 0 0 1 1 1 1 Kinesin-associated Fez1 PF06818.13 T186383_2 - 0.033 14.5 28.8 0.01 16.1 11.6 2.3 2 0 0 2 2 2 0 Fez1 RhoGEF PF00621.18 T209819_1 - 1.1e-29 103.8 5.1 2e-29 103.0 5.1 1.4 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 T209819_2 - 1e-11 44.1 0.0 2.2e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T209819_2 - 2.9e-11 42.9 0.0 4.7e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T209819_2 - 1.5e-07 30.9 0.1 4.4e-07 29.3 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain PH PF00169.27 T209819_2 - 1e-05 25.8 0.0 2e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.3 T209819_2 - 0.03 14.2 0.0 0.064 13.1 0.0 1.5 1 0 0 1 1 1 0 PH domain AC_N PF16214.3 T249307_2 - 2.6e-247 820.6 0.0 2.6e-247 820.6 0.0 1.9 2 0 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region Guanylate_cyc PF00211.18 T249307_2 - 2.1e-120 398.9 3.1 7.7e-62 208.0 0.7 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.12 T249307_2 - 3.9e-27 94.7 0.2 6.9e-27 93.9 0.2 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) HNOBA PF07701.12 T249307_2 - 0.075 12.3 1.2 2.7 7.3 0.1 2.3 2 0 0 2 2 2 0 Heme NO binding associated DUF2339 PF10101.7 T249307_2 - 2.8 6.3 21.0 0.068 11.6 12.9 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2339) COesterase PF00135.26 T132903_3 - 1.3e-163 545.5 0.0 1.5e-163 545.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 T132903_3 - 2.6e-10 40.4 1.3 1.1e-09 38.3 1.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.7 T132903_3 - 0.0083 14.9 0.0 0.024 13.4 0.0 1.6 1 1 0 1 1 1 1 Steryl acetyl hydrolase Esterase PF00756.18 T132903_3 - 0.013 15.0 0.5 0.039 13.5 0.5 1.6 1 1 0 1 1 1 0 Putative esterase Peptidase_S9 PF00326.19 T132903_3 - 0.019 14.3 0.2 0.034 13.5 0.2 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family BAR_3 PF16746.3 T085579_1 - 2.2e-49 168.2 12.2 5.4e-49 166.9 10.9 2.0 1 1 1 2 2 2 1 BAR domain of APPL family PH PF00169.27 T085579_1 - 3.3e-10 40.3 0.0 1.1e-07 32.1 0.0 2.6 2 0 0 2 2 2 1 PH domain PID PF00640.21 T085579_1 - 8.3e-07 29.0 1.2 1.1e-06 28.6 0.2 1.7 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 T085579_1 - 2.3e-05 24.4 0.1 4.9e-05 23.4 0.1 1.5 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PH_9 PF15410.4 T085579_1 - 0.0069 16.6 0.0 0.021 15.0 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.8 T085579_1 - 0.063 13.5 0.0 0.24 11.7 0.0 2.0 2 0 0 2 2 2 0 Plant pleckstrin homology-like region Pox_RNA_pol_35 PF03396.13 T085579_1 - 0.11 11.6 1.0 0.24 10.5 0.0 2.0 3 0 0 3 3 3 0 Poxvirus DNA-directed RNA polymerase, 35 kD subunit INCA1 PF15142.4 T140169_2 - 3.5e-21 75.9 1.6 1.1e-18 67.7 0.7 2.2 2 0 0 2 2 2 2 INCA1 INCA1 PF15142.4 T140169_3 - 9.8e-64 214.5 1.5 3e-35 121.7 0.3 2.4 2 0 0 2 2 2 2 INCA1 HECT PF00632.23 T328981_1 - 3.4e-100 335.3 0.0 4.7e-100 334.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 T328981_1 - 1.5e-14 53.4 3.4 4.2e-07 29.7 0.1 2.8 2 0 0 2 2 2 2 WW domain C2 PF00168.28 T328981_1 - 3.8e-13 49.5 0.0 7.5e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 C2 domain Mesothelin PF06060.10 T124577_3 - 6.6e-44 150.1 0.0 9.2e-44 149.6 0.0 1.1 1 0 0 1 1 1 1 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) COesterase PF00135.26 T134200_2 - 2.1e-65 221.5 0.0 2.9e-65 221.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 T134200_2 - 0.001 18.8 0.1 0.0017 18.1 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.26 T134200_3 - 2.1e-37 129.1 0.8 1.6e-23 83.3 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family MSL2-CXC PF16682.3 T178414_1 - 0.0088 16.0 1.6 0.013 15.5 1.6 1.2 1 0 0 1 1 1 1 CXC domain of E3 ubiquitin-protein ligase MSL2 BRO1 PF03097.16 T353424_1 - 4.2e-50 170.5 0.2 5.9e-50 170.1 0.2 1.1 1 0 0 1 1 1 1 BRO1-like domain BRO1 PF03097.16 T353424_3 - 4.5e-28 98.0 0.0 1.8e-18 66.4 0.0 2.1 2 0 0 2 2 2 2 BRO1-like domain HR1 PF02185.14 T353424_3 - 4.7e-18 64.9 1.3 1e-17 63.9 1.3 1.5 1 0 0 1 1 1 1 Hr1 repeat PDZ PF00595.22 T353424_3 - 4.7e-13 49.2 0.0 9.8e-13 48.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T353424_3 - 0.00026 21.1 0.0 0.00049 20.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain GAGA PF09237.9 T353424_3 - 0.22 11.2 3.0 0.24 11.1 0.2 2.6 2 0 0 2 2 2 0 GAGA factor Myosin_head PF00063.19 T154521_1 - 1.3e-121 406.9 0.0 1.8e-121 406.4 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.15 T154521_1 - 5.5e-47 158.6 6.9 8.4e-26 90.4 0.0 3.6 4 0 0 4 4 4 2 MyTH4 domain FERM_M PF00373.16 T154521_1 - 3.4e-15 56.3 1.6 6.2e-15 55.5 0.2 2.2 2 0 0 2 2 2 1 FERM central domain AAA_16 PF13191.4 T154521_1 - 0.0002 21.7 0.0 0.016 15.5 0.0 3.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 T154521_1 - 0.0077 16.4 0.0 0.029 14.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 T154521_1 - 0.073 13.1 0.0 0.26 11.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain IQ PF00612.25 T154521_1 - 0.64 9.8 3.7 2.2 8.1 3.7 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif SH3_2 PF07653.15 T154521_3 - 4.9e-10 38.8 0.0 1.1e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T154521_3 - 9.2e-08 31.7 0.0 1.5e-06 27.8 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 T154521_3 - 0.12 11.8 0.1 1.6 8.3 0.0 2.5 3 0 0 3 3 3 0 SH3 domain TTL PF03133.13 T000509_1 - 9e-44 149.6 0.0 1.3e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 T000509_1 - 3.4e-11 42.8 0.0 4.5e-05 22.7 0.0 2.1 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 T000509_1 - 0.0085 15.2 0.0 0.26 10.4 0.0 2.0 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp zf-C2H2_assoc2 PF16624.3 T332612_1 - 2e-37 127.9 16.0 2e-37 127.9 16.0 4.0 5 1 0 5 5 3 1 Unstructured region upstream of a zinc-finger zf-C2H2_4 PF13894.4 T332612_1 - 1.2e-13 50.5 55.9 0.0082 16.8 2.0 7.9 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_11 PF16622.3 T332612_1 - 1.2e-13 50.4 5.3 1.2e-13 50.4 5.3 6.2 7 0 0 7 7 7 2 zinc-finger C2H2-type zf-C2H2 PF00096.24 T332612_1 - 1.2e-10 41.1 64.0 0.0054 17.0 1.6 7.9 8 0 0 8 8 7 6 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 T332612_1 - 0.0013 18.8 1.4 0.0013 18.8 1.4 6.6 6 0 0 6 6 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 T332612_1 - 0.002 18.3 32.0 0.075 13.2 1.2 6.9 6 1 1 7 7 7 3 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.4 T332612_1 - 0.0021 17.6 0.8 0.0021 17.6 0.8 5.8 6 0 0 6 6 5 1 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.3 T332612_1 - 0.0027 17.8 1.2 0.0027 17.8 1.2 3.5 5 0 0 5 5 4 1 C2H2-type zinc ribbon zf-Di19 PF05605.10 T332612_1 - 0.0038 17.3 1.7 0.0038 17.3 1.7 5.5 5 0 0 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.3 T332612_1 - 0.0047 16.6 5.8 19 5.0 0.0 4.7 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-met PF12874.5 T332612_1 - 0.0054 16.9 0.7 0.0054 16.9 0.7 6.5 7 0 0 7 7 6 3 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 T332612_1 - 0.022 15.1 0.5 0.022 15.1 0.5 8.9 11 1 0 11 11 8 0 Zinc-finger double domain WD40 PF00400.30 T336061_2 - 4e-33 112.8 18.3 0.00015 22.4 0.1 8.7 8 0 0 8 8 8 7 WD domain, G-beta repeat Nup160 PF11715.6 T336061_2 - 6.3e-08 31.5 2.2 0.22 9.9 0.0 6.2 6 1 1 7 7 7 3 Nucleoporin Nup120/160 PQQ_3 PF13570.4 T336061_2 - 0.00015 22.0 6.6 4.2 7.9 0.1 5.9 5 1 1 6 6 6 2 PQQ-like domain ANAPC4_WD40 PF12894.5 T336061_2 - 0.00044 20.4 0.3 6.9 6.9 0.0 4.4 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.4 T336061_2 - 0.022 14.2 0.2 0.11 11.9 0.1 2.2 1 1 1 2 2 2 0 PQQ-like domain UCH PF00443.27 T367624_1 - 2.1e-25 89.6 0.0 2.8e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 T367624_1 - 1.5e-15 57.1 5.8 4.4e-15 55.6 5.8 1.9 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein DUSP PF06337.10 T367624_2 - 6.7e-26 90.6 0.3 3.8e-16 59.3 0.0 2.4 2 0 0 2 2 2 2 DUSP domain UCH PF00443.27 T367624_2 - 2.8e-24 85.9 0.0 6.6e-24 84.7 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 T367624_2 - 5.8e-08 32.6 0.0 1.3e-06 28.2 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Pkinase PF00069.23 T177405_2 - 8.3e-51 172.7 0.0 1.1e-50 172.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T177405_2 - 1.3e-23 83.5 0.0 1.8e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.8 T177405_2 - 2.3e-20 72.3 15.1 3.4e-20 71.8 15.1 1.2 1 0 0 1 1 1 1 DMPK coiled coil domain like Kinase-like PF14531.4 T177405_2 - 3.7e-07 29.6 0.0 6.1e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.4 T177405_2 - 0.0031 17.0 0.0 0.094 12.2 0.0 2.1 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 T177405_2 - 0.0089 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AP_endonuc_2 PF01261.22 T177405_2 - 0.21 10.9 0.2 0.34 10.2 0.2 1.2 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Laminin_II PF06009.10 T177405_2 - 0.81 9.6 2.7 1.3 8.9 2.7 1.1 1 0 0 1 1 1 0 Laminin Domain II DUF3450 PF11932.6 T177405_2 - 0.99 8.5 6.4 1.5 7.9 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Tmemb_cc2 PF10267.7 T177405_2 - 2.4 7.1 5.7 3.5 6.6 5.7 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein WD40 PF00400.30 T177405_3 - 6.4e-11 42.5 0.4 0.002 18.8 0.2 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T177405_3 - 0.0011 19.1 0.0 13 6.1 0.0 3.3 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.10 T177405_3 - 0.1 12.5 1.3 8.1 6.4 0.0 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat zf-rbx1 PF12678.5 T063316_1 - 8.7e-05 22.6 5.1 0.00031 20.8 5.1 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 T063316_1 - 2.1 8.2 17.0 0.014 15.2 5.8 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Pox_vIL-18BP PF05566.10 T063316_2 - 0.061 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Orthopoxvirus interleukin 18 binding protein EP400_N PF15790.3 T090032_2 - 6.1e-183 609.0 14.8 6.1e-183 609.0 14.8 3.0 2 1 1 3 3 3 1 E1A-binding protein p400, N-terminal HSA PF07529.11 T090032_2 - 9.9e-14 51.3 0.6 9.9e-14 51.3 0.6 2.1 2 0 0 2 2 2 1 HSA PWWP PF00855.15 T342217_1 - 1.9e-21 76.2 1.9 4e-21 75.1 1.9 1.6 1 0 0 1 1 1 1 PWWP domain PAP2 PF01569.19 T342217_2 - 2e-29 102.0 1.7 2e-29 102.0 1.7 2.2 2 0 0 2 2 2 1 PAP2 superfamily SET PF00856.26 T342217_2 - 9.4e-20 71.5 0.1 2e-19 70.5 0.1 1.6 1 0 0 1 1 1 1 SET domain PWWP PF00855.15 T342217_2 - 3.3e-19 69.0 0.2 8.3e-19 67.7 0.2 1.7 1 0 0 1 1 1 1 PWWP domain PHD PF00628.27 T342217_2 - 5.6e-09 35.6 67.0 0.0017 18.1 9.3 6.8 4 1 1 5 5 5 4 PHD-finger RRM_1 PF00076.20 T010825_1 - 6.3e-42 141.1 0.0 2.5e-20 71.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 T010825_1 - 6.3e-08 32.1 0.0 0.00011 21.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 T010825_3 - 3.6e-06 26.6 0.0 6.2e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UBA_4 PF14555.4 T020299_1 - 0.00031 20.4 0.0 0.00053 19.6 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.11 T020299_1 - 0.0015 17.9 0.0 0.0041 16.6 0.0 1.7 1 0 0 1 1 1 1 TAP C-terminal domain Myotub-related PF06602.12 T020299_2 - 4.8e-31 107.8 0.1 6.5e-31 107.4 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain OTU PF02338.17 T020299_2 - 5e-24 85.1 0.0 7.8e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease 3-PAP PF12578.6 T020299_2 - 6.1e-22 77.7 0.3 1.1e-21 76.8 0.3 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein zf-A20 PF01754.14 T020299_2 - 1.2e-05 25.0 12.2 5.4e-05 22.9 12.2 2.3 1 0 0 1 1 1 1 A20-like zinc finger RRM_1 PF00076.20 T020299_3 - 5.1e-37 125.4 0.0 1.4e-18 66.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Myotub-related PF06602.12 T020299_3 - 1.2e-15 57.2 0.0 2.3e-10 39.8 0.0 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain RRM_7 PF16367.3 T020299_3 - 0.0002 21.3 0.0 0.019 15.0 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif RVT_1 PF00078.25 T303375_2 - 1.1e-50 172.1 1.9 2e-50 171.3 1.9 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) V-set PF07686.15 T303375_3 - 5.9e-07 29.5 0.1 1.1e-06 28.6 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain PH PF00169.27 T080556_1 - 2.7e-09 37.3 0.0 5.5e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 PH domain WW PF00397.24 T080556_1 - 3.3e-06 26.8 0.0 7e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 WW domain PH_9 PF15410.4 T080556_1 - 0.06 13.6 0.0 0.091 13.0 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain GHMP_kinases_C PF08544.11 T080556_1 - 0.097 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 GHMP kinases C terminal RhoGAP PF00620.25 T080556_2 - 2.2e-50 170.3 0.0 3e-50 169.8 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain PRY PF13765.4 T295295_1 - 5.3e-13 48.2 0.0 1.2e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain V-set PF07686.15 T295295_1 - 2.2e-10 40.5 0.0 4.8e-10 39.4 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain SPRY PF00622.26 T295295_1 - 1.4e-09 37.9 0.0 2.7e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 SPRY domain Ig_3 PF13927.4 T295295_1 - 0.0079 16.6 0.0 0.074 13.5 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 T295295_1 - 0.1 12.6 0.0 0.64 10.0 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin I-set domain Bromodomain PF00439.23 T201764_3 - 1.2e-20 73.3 0.0 2.7e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain MBD PF01429.17 T201764_3 - 2.6e-20 71.8 0.0 5.7e-20 70.7 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain PHD PF00628.27 T201764_3 - 2.3e-11 43.3 9.2 6.8e-11 41.7 9.2 1.9 1 0 0 1 1 1 1 PHD-finger WSD PF15613.4 T201764_3 - 8.8e-11 42.1 0.1 4.5e-07 30.2 0.1 4.7 5 0 0 5 5 5 2 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.15 T201764_3 - 6.1e-09 35.9 0.3 1.3e-08 34.9 0.3 1.6 1 0 0 1 1 1 1 DDT domain RNA_pol_3_Rpc31 PF11705.6 T201764_3 - 0.0014 18.8 1.0 0.0014 18.8 1.0 6.3 5 2 0 5 5 5 1 DNA-directed RNA polymerase III subunit Rpc31 RhoGEF PF00621.18 T188004_2 - 7.3e-09 36.0 0.6 1.2e-08 35.3 0.6 1.3 1 0 0 1 1 1 1 RhoGEF domain ATE_C PF04377.13 T049771_3 - 1.7e-52 177.5 1.0 2.7e-52 176.8 1.0 1.3 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.11 T049771_3 - 7.5e-31 106.2 6.2 1.5e-30 105.2 6.2 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Pro-rich PF15240.4 T073951_1 - 8.3e-35 120.5 73.6 1.2e-34 120.0 73.6 1.2 1 0 0 1 1 1 1 Proline-rich AIP3 PF03915.11 T146504_3 - 1.8e-08 33.8 4.9 2.7e-07 29.9 0.0 2.1 2 0 0 2 2 2 2 Actin interacting protein 3 Lig_chan-Glu_bd PF10613.7 T068958_2 - 9.3e-42 141.7 0.0 3.2e-41 140.0 0.0 1.8 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.24 T068958_2 - 1.2e-16 60.7 0.0 6e-14 52.0 0.0 2.3 1 1 1 2 2 2 2 Ligand-gated ion channel SBP_bac_3 PF00497.18 T068958_2 - 4.2e-14 52.4 0.0 9.6e-14 51.2 0.0 1.5 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.26 T068958_3 - 5.6e-61 206.5 0.0 7.7e-61 206.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 T068958_3 - 0.04 13.6 0.1 0.094 12.4 0.0 1.7 2 0 0 2 2 2 0 Ligand-gated ion channel zf-RING_2 PF13639.4 T224801_3 - 1.3e-06 28.4 8.3 3.5e-06 27.0 8.3 1.8 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.5 T224801_3 - 0.00014 21.7 1.9 0.00041 20.2 1.9 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.6 T224801_3 - 0.00015 21.7 5.4 0.00038 20.5 5.4 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.5 T224801_3 - 0.0016 18.6 7.3 0.0046 17.1 7.3 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain RINGv PF12906.5 T224801_3 - 0.017 15.1 6.7 0.042 13.8 6.7 1.7 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4 PF00097.23 T224801_3 - 0.022 14.5 9.7 0.055 13.2 9.7 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.3 T224801_3 - 0.13 11.7 5.6 0.46 10.0 5.6 1.9 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.4 T224801_3 - 0.37 10.5 8.6 0.95 9.2 8.6 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.9 T224801_3 - 0.37 11.0 6.6 1.1 9.5 6.6 1.8 1 0 0 1 1 1 0 RING-like domain Zf_RING PF16744.3 T224801_3 - 0.65 10.0 3.3 1.5 8.8 3.3 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger PHD PF00628.27 T224801_3 - 6.3 6.6 6.7 17 5.2 6.7 1.8 1 0 0 1 1 1 0 PHD-finger TTKRSYEDQ PF10212.7 T189173_2 - 4.8e-266 883.6 25.9 4.8e-266 883.6 25.9 2.3 2 1 0 2 2 2 1 Predicted coiled-coil domain-containing protein KLRAQ PF10205.7 T189173_2 - 8.3e-35 118.9 14.5 8.3e-35 118.9 14.5 4.0 4 0 0 4 4 4 1 Predicted coiled-coil domain-containing protein Adap_comp_sub PF00928.19 T189173_3 - 2e-63 214.1 0.7 2.7e-63 213.7 0.7 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Transposase_22 PF02994.12 T334097_1 - 1.2e-14 53.9 8.5 3.8e-14 52.2 8.5 1.7 1 1 0 1 1 1 1 L1 transposable element DAGK_acc PF00609.17 T334097_3 - 4.4e-46 157.0 0.0 7e-46 156.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 T334097_3 - 1.8e-27 95.3 0.0 3.1e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Gag_p30 PF02093.14 T334097_3 - 1.4e-12 47.5 0.0 2.2e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein C1_1 PF00130.20 T334097_3 - 8.2e-12 44.7 27.6 9e-10 38.2 16.1 3.2 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_2 PF12796.5 T334097_3 - 2.7e-11 43.8 0.1 5.4e-11 42.8 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T334097_3 - 2.2e-05 24.8 0.0 6.4e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 T334097_3 - 3.4e-05 23.8 0.1 0.16 12.5 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 T334097_3 - 4.6e-05 23.5 0.0 0.27 11.6 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 T334097_3 - 0.00016 21.8 0.4 0.54 10.7 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat DAGK_acc PF00609.17 T080054_2 - 1e-49 168.8 0.0 1.6e-49 168.2 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAG_kinase_N PF14513.4 T080054_2 - 9.8e-37 126.6 4.8 3.2e-30 105.4 0.8 2.3 1 1 1 2 2 2 2 Diacylglycerol kinase N-terminus DAGK_cat PF00781.22 T080054_2 - 2.9e-26 91.4 0.0 5e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 T080054_2 - 9.2e-23 79.8 22.9 1.6e-13 50.1 1.7 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.30 T080054_2 - 1e-08 33.9 0.1 0.0018 17.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T080054_2 - 4.9e-07 29.1 0.0 0.004 16.9 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.4 T080054_2 - 3.3e-06 27.3 0.1 1e-05 25.8 0.2 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.4 T080054_2 - 4.3e-05 22.7 0.1 0.16 11.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 T080054_2 - 0.0014 18.2 0.1 0.52 10.0 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain pair C1_2 PF03107.14 T080054_2 - 0.0066 16.6 13.5 0.013 15.7 1.2 2.6 2 0 0 2 2 2 1 C1 domain NPF PF16601.3 T238582_2 - 2.6e-78 262.7 21.6 3.7e-78 262.2 21.6 1.2 1 0 0 1 1 1 1 Rabosyn-5 repeating NPF sequence-motif Rbsn PF11464.6 T238582_2 - 6.2e-29 99.3 7.4 5.2e-16 58.0 1.3 2.6 2 0 0 2 2 2 2 Rabenosyn Rab binding domain FYVE PF01363.19 T238582_2 - 8.5e-17 60.9 6.6 3.3e-16 59.0 6.6 2.1 1 0 0 1 1 1 1 FYVE zinc finger L51_S25_CI-B8 PF05047.14 T238582_3 - 3.4e-09 36.3 0.2 6.2e-09 35.5 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain zinc_ribbon_11 PF11682.6 T314689_1 - 0.00046 20.1 7.9 3.1 7.7 0.0 6.3 7 0 0 7 7 7 2 Probable zinc-ribbon Antimicrobial13 PF08108.9 T314689_1 - 0.0012 18.6 2.7 16 5.6 0.2 5.6 4 0 0 4 4 4 2 Halocidin family Kringle PF00051.16 T314689_2 - 1.7e-263 851.6 148.8 9.9e-30 102.6 7.9 10.3 10 0 0 10 10 10 10 Kringle domain KduI PF04962.10 T314689_2 - 0.7 9.0 30.4 8.9 5.4 0.1 8.0 8 0 0 8 8 8 0 KduI/IolB family UCH PF00443.27 T117909_1 - 2.6e-60 203.9 0.2 4.1e-60 203.3 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 T117909_1 - 2.8e-21 76.3 0.0 9.7e-21 74.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 T117909_1 - 4.6e-19 68.4 14.5 4.6e-19 68.4 14.5 2.5 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein F-box-like PF12937.5 T117909_1 - 3.3e-05 23.5 0.9 0.00017 21.3 0.9 2.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T117909_1 - 0.0098 15.6 1.3 0.033 13.9 1.3 2.0 1 0 0 1 1 1 1 F-box domain zf-RVT PF13966.4 T117909_3 - 0.025 15.3 1.4 0.073 13.8 1.4 1.8 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase KRAB PF01352.25 T335543_2 - 5.9e-29 99.3 4.4 3.7e-20 71.2 0.7 2.5 2 0 0 2 2 2 2 KRAB box Dimer_Tnp_hAT PF05699.12 T335543_2 - 4.6e-07 29.4 0.2 9.9e-07 28.3 0.2 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4371 PF14291.4 T335543_2 - 0.038 13.5 0.0 0.074 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) VCX_VCY PF15231.4 T371052_2 - 1.6e-77 258.8 51.8 1e-69 233.5 31.8 2.2 1 1 1 2 2 2 2 Variable charge X/Y family Lipocalin PF00061.21 T368807_3 - 3e-31 108.4 0.0 4.1e-31 108.0 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family C2 PF00168.28 T179312_1 - 2.1e-51 172.4 0.0 9.1e-27 93.2 0.0 2.3 2 0 0 2 2 2 2 C2 domain DOCK-C2 PF14429.4 T179312_1 - 0.12 12.1 0.0 0.59 9.8 0.1 1.8 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins Telomerase_RBD PF12009.6 T277588_1 - 3.5e-17 62.6 0.0 5.6e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain Telomerase_RBD PF12009.6 T277588_2 - 5.9e-18 65.1 0.2 1e-17 64.3 0.2 1.3 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.25 T277588_2 - 3.4e-12 46.2 0.0 1.3e-07 31.3 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) CD20 PF04103.13 T360004_2 - 5.7e-17 62.1 3.1 9.7e-17 61.3 3.1 1.3 1 0 0 1 1 1 1 CD20-like family Ank_4 PF13637.4 T284927_1 - 9.2e-18 64.2 0.1 4.7e-06 26.9 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 T284927_1 - 7.3e-16 58.4 0.6 3.1e-10 40.3 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 T284927_1 - 8.1e-14 51.2 0.8 1.7e-05 24.9 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.4 T284927_1 - 9.5e-10 38.4 0.0 9.5e-05 22.5 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 T284927_1 - 1.8e-09 36.9 0.1 0.0011 19.1 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat BmKX PF09132.8 T233231_1 - 0.45 10.4 4.8 1.2 9.0 4.8 1.7 1 0 0 1 1 1 0 BmKX C1q PF00386.19 T233231_3 - 3.7e-37 127.2 0.4 4.9e-37 126.9 0.4 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 T233231_3 - 2.4e-07 30.3 16.2 6.2e-07 28.9 16.2 1.7 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) IIGP PF05049.11 T291500_1 - 5.8e-63 213.1 0.1 8.2e-63 212.6 0.1 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Ribosomal_L33 PF00471.18 T186890_2 - 3.5e-05 24.0 0.1 3.5e-05 24.0 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L33 KRAB PF01352.25 T159237_2 - 1.4e-25 88.5 0.2 2.6e-25 87.7 0.2 1.4 1 0 0 1 1 1 1 KRAB box Serglycin PF04360.10 T043193_2 - 1.2e-78 262.0 0.1 1.7e-78 261.6 0.1 1.2 1 0 0 1 1 1 1 Serglycin Ribonuc_2-5A PF06479.10 T128996_2 - 5.6e-40 136.3 0.1 8.4e-40 135.7 0.1 1.3 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.23 T128996_2 - 1e-37 129.9 0.0 1.3e-37 129.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T128996_2 - 4.3e-18 65.4 0.0 6.1e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.4 T128996_2 - 3.5e-05 23.4 0.0 0.054 12.9 0.0 2.7 1 1 0 2 2 2 2 PQQ-like domain PQQ_3 PF13570.4 T128996_2 - 0.0031 17.8 0.4 14 6.2 0.0 4.1 4 0 0 4 4 4 1 PQQ-like domain APH PF01636.21 T128996_2 - 0.038 13.8 4.7 0.21 11.3 0.1 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.12 T128996_2 - 0.12 11.6 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ PF01011.19 T128996_2 - 0.14 12.0 0.0 0.99 9.3 0.0 2.3 2 0 0 2 2 2 0 PQQ enzyme repeat Pkinase_Tyr PF07714.15 T295158_2 - 1.3e-99 332.6 0.0 1.7e-99 332.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 T295158_2 - 3.1e-51 171.8 4.7 8.7e-11 42.2 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 T295158_2 - 1.8e-39 133.6 0.3 1.4e-14 53.8 0.0 7.9 6 2 1 7 7 7 5 Immunoglobulin I-set domain Pkinase PF00069.23 T295158_2 - 2.9e-39 134.9 0.0 1.1e-27 96.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_2 PF13895.4 T295158_2 - 3e-38 129.9 5.6 5.9e-08 32.8 0.0 8.7 8 1 0 8 8 8 6 Immunoglobulin domain ig PF00047.23 T295158_2 - 4.1e-30 103.7 2.3 7.5e-08 32.3 0.1 7.4 7 0 0 7 7 7 4 Immunoglobulin domain V-set PF07686.15 T295158_2 - 1.4e-14 54.0 7.3 0.005 16.9 0.0 6.9 6 3 2 8 8 8 3 Immunoglobulin V-set domain Izumo-Ig PF16706.3 T295158_2 - 4e-07 29.8 2.2 1.6 8.7 0.0 5.9 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 T295158_2 - 0.0014 18.5 5.0 2.2 8.3 0.0 4.8 6 0 0 6 6 6 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 T295158_2 - 0.0035 17.7 1.3 0.45 10.9 0.0 4.5 6 0 0 6 6 6 1 Immunoglobulin C1-set domain Galactosyl_T PF01762.19 T255771_2 - 3.5e-46 157.3 0.0 4.7e-46 156.9 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 T255771_2 - 0.0016 17.8 0.0 0.0034 16.7 0.0 1.4 1 1 0 1 1 1 1 Fringe-like Joubert PF15392.4 T281101_1 - 4.1e-163 542.8 2.9 4.1e-163 542.8 2.9 2.5 3 0 0 3 3 3 1 Joubert syndrome-associated Myosin_head PF00063.19 T144822_3 - 7.9e-112 374.6 2.9 2e-100 336.9 0.0 2.9 4 0 0 4 4 2 2 Myosin head (motor domain) Myosin_tail_1 PF01576.17 T144822_3 - 1.5e-19 69.3 180.5 3.2e-18 64.9 105.6 2.4 1 1 1 2 2 2 2 Myosin tail PDZ PF00595.22 T144822_3 - 2.7e-07 30.7 0.0 6e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) ATG16 PF08614.9 T144822_3 - 0.00048 20.2 15.9 0.00048 20.2 15.9 7.3 2 1 5 7 7 5 2 Autophagy protein 16 (ATG16) IQ PF00612.25 T144822_3 - 0.0012 18.3 0.3 0.0012 18.3 0.3 2.1 2 0 0 2 2 1 1 IQ calmodulin-binding motif PKcGMP_CC PF16808.3 T144822_3 - 0.0013 18.4 2.7 0.0013 18.4 2.7 8.0 8 0 0 8 8 7 1 Coiled-coil N-terminus of cGMP-dependent protein kinase AAA_22 PF13401.4 T144822_3 - 0.049 13.8 2.6 0.073 13.2 0.0 2.7 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.4 T144822_3 - 0.051 13.8 0.0 0.051 13.8 0.0 5.3 4 2 0 4 4 2 0 AAA ATPase domain ATP_bind_1 PF03029.15 T144822_3 - 0.067 12.8 0.2 3.2 7.3 0.2 2.9 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.4 T144822_3 - 0.12 12.6 2.1 0.24 11.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain DUF258 PF03193.14 T144822_3 - 0.16 11.7 1.0 3.4 7.4 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function, DUF258 AAA_18 PF13238.4 T144822_3 - 0.28 11.5 4.8 0.32 11.4 0.0 3.1 2 1 0 2 2 2 0 AAA domain Reo_sigmaC PF04582.10 T144822_3 - 2.8 7.1 40.6 0.031 13.5 4.3 6.1 3 1 4 7 7 7 0 Reovirus sigma C capsid protein TTL PF03133.13 T107597_1 - 1.8e-91 306.2 0.1 4.4e-91 304.9 0.1 1.6 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 T107597_1 - 1.4e-06 27.6 0.0 0.0034 16.5 0.0 2.5 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 T107597_1 - 0.0024 17.0 0.0 0.31 10.1 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp Angiomotin_C PF12240.6 T065997_2 - 6.3e-96 319.7 15.9 6.3e-96 319.7 15.9 3.4 2 1 0 2 2 2 2 Angiomotin C terminal Syja_N PF02383.16 T225147_3 - 1.1e-70 238.2 0.2 1.6e-70 237.8 0.2 1.2 1 0 0 1 1 1 1 SacI homology domain DUF1866 PF08952.9 T225147_3 - 4.4e-60 201.6 0.2 8.8e-60 200.7 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.21 T225147_3 - 4.5e-09 36.4 0.0 9.6e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Oxidored_molyb PF00174.17 T080116_1 - 3.4e-62 209.0 0.0 5.7e-62 208.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.14 T080116_1 - 6.3e-43 146.0 0.3 1.1e-42 145.2 0.3 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.26 T080116_1 - 1.7e-12 47.1 0.0 2.8e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain zf-H2C2_2 PF13465.4 T080116_3 - 7.7e-13 48.1 42.7 3.4e-07 30.3 2.8 6.9 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2 PF00096.24 T080116_3 - 1.1e-12 47.5 43.4 0.00045 20.4 1.3 7.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T080116_3 - 2.9e-05 24.4 49.0 0.0057 17.2 1.1 8.1 7 0 0 7 7 7 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T080116_3 - 0.0077 15.8 1.1 0.0077 15.8 1.1 4.7 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 T080116_3 - 5.8 6.9 33.6 0.078 12.8 3.9 6.1 7 0 0 7 7 7 0 C2H2-type zinc finger GAGA PF09237.9 T080116_3 - 8.9 6.1 7.5 0.88 9.3 0.1 2.8 2 1 1 3 3 3 0 GAGA factor zf-H2C2_2 PF13465.4 T241266_2 - 2.2e-34 116.2 34.9 4.5e-08 33.1 0.9 6.6 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 T241266_2 - 2.9e-27 93.4 32.4 1.1e-06 28.7 0.6 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T241266_2 - 5.5e-13 48.4 31.0 0.0018 18.8 0.4 5.8 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T241266_2 - 1.2e-09 37.7 26.6 0.0072 16.1 0.2 6.2 5 1 0 5 5 5 5 C2H2-type zinc finger KRAB PF01352.25 T241266_2 - 4.3e-09 35.8 0.3 1e-08 34.5 0.1 1.7 2 0 0 2 2 1 1 KRAB box XPA_N PF01286.16 T241266_2 - 9.9e-06 25.4 12.5 2.8 7.9 0.4 5.5 5 0 0 5 5 5 3 XPA protein N-terminal Zn-ribbon_8 PF09723.8 T241266_2 - 0.00025 21.0 24.1 0.14 12.2 4.2 3.8 2 2 1 3 3 3 3 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T241266_2 - 0.004 17.3 18.1 0.66 10.2 0.1 5.2 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T241266_2 - 0.032 14.8 16.5 0.36 11.5 2.6 3.2 1 1 2 3 3 3 0 zinc-ribbon family CpXC PF14353.4 T241266_2 - 0.6 10.0 11.8 17 5.3 0.1 4.5 3 2 1 4 4 4 0 CpXC protein GATA PF00320.25 T241266_2 - 0.62 9.6 9.3 2.3 7.8 0.1 4.1 4 0 0 4 4 4 0 GATA zinc finger C1_4 PF07975.10 T241266_2 - 0.65 10.2 18.1 1.8 8.8 2.5 3.9 2 1 2 4 4 4 0 TFIIH C1-like domain GAGA PF09237.9 T241266_2 - 0.9 9.3 5.3 1.9 8.2 0.1 3.0 1 1 3 4 4 4 0 GAGA factor zf-C4_ClpX PF06689.11 T241266_2 - 1.4 8.7 5.6 3.8 7.3 0.7 3.4 3 0 0 3 3 3 0 ClpX C4-type zinc finger HypA PF01155.17 T241266_2 - 2.7 7.9 13.9 16 5.4 4.3 3.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_11 PF16622.3 T241266_2 - 2.8 7.6 15.9 0.62 9.7 0.1 4.7 5 0 0 5 5 5 0 zinc-finger C2H2-type Zn_Tnp_IS1595 PF12760.5 T241266_2 - 3.7 7.5 23.4 12 5.9 5.0 4.7 3 2 1 4 4 4 0 Transposase zinc-ribbon domain ZZ PF00569.15 T241266_2 - 4 7.2 16.9 24 4.7 0.1 5.1 5 0 0 5 5 5 0 Zinc finger, ZZ type zf-trcl PF13451.4 T241266_2 - 4 7.3 16.8 13 5.6 0.1 5.0 4 1 0 4 4 4 0 Probable zinc-ribbon domain DUF3268 PF11672.6 T241266_2 - 4.6 7.5 13.4 12 6.1 1.1 3.2 1 1 3 4 4 4 0 zinc-finger-containing domain zf-C2HE PF16278.3 T241266_2 - 6.2 7.2 20.8 0.27 11.6 0.2 4.9 2 1 3 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger Zn_ribbon_recom PF13408.4 T241266_2 - 8 6.9 16.3 94 3.5 0.1 4.2 1 1 1 2 2 1 0 Recombinase zinc beta ribbon domain STT3 PF02516.12 T069700_1 - 2.3e-164 547.8 41.3 6.5e-160 533.1 36.7 2.2 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Pkinase PF00069.23 T069700_1 - 4.7e-41 140.7 0.0 9.4e-41 139.8 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 T069700_1 - 2.4e-18 66.2 0.0 4.1e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T069700_1 - 6.8e-06 25.5 0.0 9.8e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PMT_2 PF13231.4 T069700_1 - 1.3e-05 25.4 13.3 4.8e-05 23.5 13.3 2.0 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MRP-S22 PF10245.7 T251337_1 - 2e-105 351.8 2.6 2.9e-105 351.2 2.6 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S22 NADH_dh_m_C1 PF15088.4 T251337_1 - 0.045 13.2 0.3 0.091 12.2 0.3 1.4 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Glyco_transf_7N PF13733.4 T009629_1 - 7.4e-55 184.1 0.0 1.2e-54 183.4 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 CCDC24 PF15669.3 T009629_1 - 2.6e-42 144.9 17.0 7.5e-24 84.6 1.9 2.9 2 1 1 3 3 3 2 Coiled-coil domain-containing protein 24 family Glyco_transf_7C PF02709.12 T009629_1 - 1.4e-30 104.6 2.8 2.2e-30 104.0 0.4 2.3 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 T009629_1 - 0.044 13.1 0.0 0.069 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 DUF454 PF04304.11 T147097_1 - 0.21 11.5 0.8 0.39 10.6 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF454) Connexin PF00029.17 T147097_3 - 9e-77 257.7 0.1 2.1e-76 256.5 0.1 1.7 1 1 0 1 1 1 1 Connexin Metallophos PF00149.26 T307559_2 - 0.0099 16.3 0.0 0.014 15.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase zf-C2H2_6 PF13912.4 T303674_2 - 8.1e-12 44.7 7.4 8.5e-05 22.3 0.2 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger ELM2 PF01448.22 T303674_2 - 1.6e-06 28.6 0.0 1.6e-06 28.6 0.0 3.0 3 0 0 3 3 3 1 ELM2 domain zf-C2H2_4 PF13894.4 T303674_2 - 2.3e-06 27.8 9.9 0.057 14.1 0.1 5.4 4 0 0 4 4 4 2 C2H2-type zinc finger Myb_DNA-binding PF00249.29 T303674_2 - 0.0012 18.8 0.1 0.0027 17.7 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-CW PF07496.13 T303674_2 - 0.015 15.2 0.3 0.015 15.2 0.3 2.0 2 0 0 2 2 2 0 CW-type Zinc Finger zf-C2H2 PF00096.24 T303674_2 - 0.02 15.2 24.3 0.058 13.7 1.2 5.8 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 T303674_2 - 0.025 14.7 2.4 2.7 8.3 0.7 3.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Sigma70_ner PF04546.11 T303674_2 - 0.061 13.1 2.1 0.14 11.9 2.1 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region zf-C2H2_2 PF12756.5 T303674_2 - 0.091 13.0 9.7 0.14 12.4 0.1 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) Myb_DNA-bind_7 PF15963.3 T303674_2 - 0.88 9.4 4.9 0.11 12.3 0.2 1.8 2 0 0 2 2 2 0 Myb DNA-binding like Glyco_hydro_35 PF01301.17 T070905_2 - 5.8e-104 348.0 0.1 7.5e-100 334.5 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.13 T070905_2 - 9.3e-12 44.8 0.0 6.7e-11 42.0 0.0 2.0 1 1 0 1 1 1 1 Beta-galactosidase Cellulase PF00150.16 T070905_2 - 0.1 11.9 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) zf-H2C2_2 PF13465.4 T241360_1 - 1.5e-105 341.1 113.7 2.1e-09 37.3 1.7 15.6 15 0 0 15 15 15 14 Zinc-finger double domain zf-C2H2 PF00096.24 T241360_1 - 3e-67 219.4 132.0 2.3e-06 27.6 1.4 14.9 14 0 0 14 14 14 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T241360_1 - 6.2e-33 110.5 122.9 0.0052 17.4 1.4 15.4 14 0 0 14 14 14 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T241360_1 - 3.1e-16 58.8 100.6 0.0067 16.2 0.9 14.9 14 0 0 14 14 14 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T241360_1 - 2.1e-12 46.8 81.2 0.00093 19.1 1.5 9.9 7 5 4 11 11 11 9 Zinc ribbon domain XPA_N PF01286.16 T241360_1 - 1.1e-10 41.2 67.4 0.78 9.7 0.1 14.4 14 0 0 14 14 14 7 XPA protein N-terminal zinc_ribbon_15 PF17032.3 T241360_1 - 1.1e-05 25.9 67.3 0.51 11.0 4.0 7.8 1 1 7 8 8 8 6 zinc-ribbon family zf-C2H2_11 PF16622.3 T241360_1 - 0.0044 16.6 85.1 0.19 11.4 1.1 13.5 14 0 0 14 14 14 7 zinc-finger C2H2-type Pox_A12 PF04651.11 T241360_1 - 0.063 13.2 0.6 0.21 11.5 0.6 1.8 1 0 0 1 1 1 0 Poxvirus A12 protein zf-C2H2_jaz PF12171.6 T241360_1 - 0.14 12.3 80.3 0.3 11.3 0.4 13.2 13 0 0 13 13 13 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 T241360_1 - 0.62 10.3 50.7 0.16 12.2 0.9 7.4 5 2 4 9 9 9 0 zinc-finger-containing domain SPRY PF00622.26 T251498_2 - 1.1e-17 64.1 0.0 1.8e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 SPRY domain SOCS_box PF07525.14 T251498_2 - 1e-11 44.8 5.0 3.4e-11 43.2 5.0 2.0 1 0 0 1 1 1 1 SOCS box zf-CCCH PF00642.22 T173936_1 - 0.019 14.8 2.3 0.036 13.9 0.5 2.6 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH PF00642.22 T173936_2 - 0.027 14.2 2.4 0.076 12.8 2.4 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.20 T173936_3 - 0.00065 19.3 0.0 0.001 18.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Oxidored-like PF09791.7 T011395_2 - 4.4e-10 38.9 1.0 4.4e-10 38.9 1.0 2.0 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal NAD_binding_1 PF00175.19 T011395_2 - 7.7e-09 36.0 0.0 1.2e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.10 T011395_2 - 0.11 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Ferric reductase NAD binding domain FAD_binding_6 PF00970.22 T011395_3 - 0.016 15.4 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain HpcH_HpaI PF03328.12 T098154_2 - 2.1e-42 144.7 0.0 2.9e-42 144.2 0.0 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.4 T098154_2 - 2.2e-08 33.5 0.0 5.6e-07 28.9 0.0 2.1 1 1 0 1 1 1 1 C-C_Bond_Lyase of the TIM-Barrel fold C4 PF01413.17 T099097_3 - 8e-82 270.8 1.1 9.7e-44 148.1 0.1 2.3 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Collagen PF01391.16 T099097_3 - 1e-10 41.1 61.4 1.3e-06 27.9 24.6 4.0 2 1 1 3 3 3 2 Collagen triple helix repeat (20 copies) Hormone_3 PF00159.16 T320100_3 - 1.8e-17 63.0 4.2 2.5e-17 62.6 1.4 2.2 2 0 0 2 2 2 1 Pancreatic hormone peptide Acetyltransf_1 PF00583.23 T060509_2 - 0.00026 21.1 0.0 0.00055 20.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family TPT PF03151.14 T000981_1 - 3e-08 33.2 0.0 4.5e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family Pkinase PF00069.23 T000981_3 - 2.5e-66 223.6 0.0 5.5e-66 222.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T000981_3 - 2.3e-30 105.6 0.0 3.6e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T000981_3 - 3.1e-06 26.6 0.2 0.00019 20.7 0.0 2.4 1 1 0 2 2 2 2 Kinase-like RNase_T PF00929.22 T368265_3 - 1.8e-18 67.5 0.0 2.5e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Exonuclease Gpi1 PF05024.13 T124233_1 - 6.8e-65 218.6 7.5 9.2e-65 218.2 7.5 1.2 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) zf-C2H2_7 PF15269.4 T124233_1 - 2.8e-35 120.0 10.0 1.1e-34 118.1 10.0 2.1 1 0 0 1 1 1 1 Zinc-finger Kunitz_BPTI PF00014.21 T124233_1 - 9.5e-25 86.5 7.6 3.4e-17 62.3 1.7 2.7 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Ig_3 PF13927.4 T124233_1 - 6e-15 55.5 0.1 1.4e-14 54.3 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T124233_1 - 4.7e-14 52.1 0.0 7.4e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 T124233_1 - 5.2e-10 39.4 0.0 1.1e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T124233_1 - 6.7e-09 35.7 0.0 1.6e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain WAP PF00095.19 T124233_1 - 6.4e-08 32.7 10.8 6.4e-08 32.7 10.8 5.3 4 0 0 4 4 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' V-set PF07686.15 T124233_1 - 5.6e-05 23.1 0.0 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Kazal_2 PF07648.13 T124233_1 - 0.0002 21.4 0.5 0.00063 19.8 0.5 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain zf-H2C2_5 PF13909.4 T124233_1 - 4.6 7.0 6.2 9.3 6.0 6.2 1.5 1 0 0 1 1 1 0 C2H2-type zinc-finger domain NHL PF01436.19 T124233_2 - 1.2e-12 47.1 2.9 0.027 14.4 0.0 4.7 4 0 0 4 4 4 4 NHL repeat Ras PF00071.20 T124233_3 - 1.2e-37 128.9 0.0 1.5e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T124233_3 - 1.5e-19 70.3 0.0 2.2e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SOCS_box PF07525.14 T124233_3 - 1e-06 28.9 0.4 9.2e-06 25.8 0.4 2.9 1 0 0 1 1 1 1 SOCS box Arf PF00025.19 T124233_3 - 0.0017 17.7 0.0 0.0028 17.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family TSNAXIP1_N PF15739.3 T134833_3 - 5.3e-29 100.7 4.7 5.3e-29 100.7 4.7 3.3 3 1 1 4 4 4 1 Translin-associated factor X-interacting N-terminus XH PF03469.12 T134833_3 - 0.016 15.0 0.2 0.016 15.0 0.2 2.5 2 0 0 2 2 2 0 XH domain DUF4407 PF14362.4 T134833_3 - 0.51 9.5 3.7 1.1 8.5 3.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MRP-L47 PF06984.11 T134833_3 - 0.92 9.5 6.8 7.3 6.7 0.2 3.4 3 0 0 3 3 3 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DUF4600 PF15372.4 T134833_3 - 1.1 9.6 21.0 0.46 10.8 2.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4600) BMFP PF04380.11 T134833_3 - 1.4 9.3 6.4 1.6 9.1 0.8 3.3 3 0 0 3 3 3 0 Membrane fusogenic activity KxDL PF10241.7 T134833_3 - 2 8.6 15.2 7.1 6.8 2.7 4.0 3 0 0 3 3 3 0 Uncharacterized conserved protein EF-hand_11 PF08976.9 T234849_1 - 4.3e-70 233.1 6.3 2.6e-60 201.6 0.3 5.6 6 0 0 6 6 6 3 EF-hand domain EF-hand_7 PF13499.4 T234849_1 - 2.7e-26 91.7 7.8 0.00011 22.4 0.1 7.3 6 1 1 7 7 7 7 EF-hand domain pair EF-hand_6 PF13405.4 T234849_1 - 7.3e-16 56.6 6.4 0.081 12.8 0.1 7.7 8 0 0 8 8 8 4 EF-hand domain EF-hand_1 PF00036.30 T234849_1 - 3.2e-12 45.0 3.5 0.0031 16.8 0.0 7.8 9 0 0 9 9 9 3 EF hand EF-hand_8 PF13833.4 T234849_1 - 4e-09 36.0 1.3 0.016 14.8 0.0 5.7 7 0 0 7 7 7 2 EF-hand domain pair GPHH PF16905.3 T234849_1 - 0.0015 18.2 0.0 0.24 11.1 0.0 3.4 4 0 0 4 4 4 1 Voltage-dependent L-type calcium channel, IQ-associated NYD-SP28 PF14772.4 T234849_1 - 0.47 10.4 4.8 0.24 11.4 0.3 2.3 2 0 0 2 2 2 0 Sperm tail EF-hand_7 PF13499.4 T234849_2 - 3.6e-18 65.7 13.5 0.0022 18.3 0.2 6.8 6 1 0 6 6 6 4 EF-hand domain pair EF-hand_11 PF08976.9 T234849_2 - 2e-16 60.6 0.3 2.7e-05 24.9 0.0 5.0 5 0 0 5 5 5 3 EF-hand domain EF-hand_6 PF13405.4 T234849_2 - 1.4e-15 55.6 8.6 0.013 15.3 0.0 8.4 9 0 0 9 9 9 4 EF-hand domain EF-hand_1 PF00036.30 T234849_2 - 9e-12 43.5 5.6 0.063 12.7 0.0 8.9 9 0 0 9 9 9 3 EF hand EF-hand_8 PF13833.4 T234849_2 - 1.8e-07 30.7 0.7 0.022 14.4 0.1 5.0 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.4 T234849_2 - 4.7e-05 22.6 2.7 0.47 10.0 0.0 5.2 6 1 0 6 6 6 2 EF hand UPF0544 PF15749.3 T295029_1 - 2.7e-10 40.8 11.6 5e-10 39.9 11.6 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0544 DUF1725 PF08333.9 T295029_1 - 5e-06 25.9 0.0 9.1e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) LLC1 PF14945.4 T184634_2 - 0.00052 20.5 0.7 0.0012 19.3 0.7 1.5 1 1 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein Patatin PF01734.20 T052528_1 - 3.2e-14 53.5 0.1 6.7e-14 52.4 0.1 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase EF-hand_7 PF13499.4 T052528_1 - 4.7e-05 23.7 0.1 8.9e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T052528_1 - 0.0002 20.9 0.0 0.57 10.1 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain Tetraspannin PF00335.18 T052528_3 - 8.5e-48 162.8 12.0 1.2e-47 162.4 12.0 1.2 1 0 0 1 1 1 1 Tetraspanin family Ribosomal_60s PF00428.17 T052528_3 - 1.4e-23 83.1 7.6 1.4e-23 83.1 7.6 5.5 5 1 1 6 6 6 1 60s Acidic ribosomal protein CD20 PF04103.13 T052528_3 - 3.4e-05 23.9 0.3 6.1e-05 23.0 0.3 1.3 1 0 0 1 1 1 1 CD20-like family DUF4199 PF13858.4 T052528_3 - 0.0017 18.6 0.8 0.003 17.9 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) SUR7 PF06687.10 T052528_3 - 0.012 15.1 1.7 0.021 14.3 1.7 1.3 1 0 0 1 1 1 0 SUR7/PalI family DUF2569 PF10754.7 T052528_3 - 2.4 8.4 5.3 3.9 7.8 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Senescence PF06911.10 T092923_1 - 8.1e-52 175.9 3.6 1.2e-51 175.3 3.6 1.3 1 0 0 1 1 1 1 Senescence-associated protein MIT PF04212.16 T092923_1 - 4.2e-06 26.6 0.1 7.5e-06 25.8 0.1 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain zf-H2C2_2 PF13465.4 T251521_2 - 3.3e-24 84.0 83.1 4e-05 23.7 5.9 12.2 12 0 0 12 12 12 8 Zinc-finger double domain BTB PF00651.29 T251521_2 - 9.3e-22 77.2 0.1 1.8e-21 76.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 T251521_2 - 1.3e-14 53.6 78.0 0.00011 22.3 2.1 10.6 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T251521_2 - 1.2e-13 50.5 78.6 0.15 12.9 0.8 11.3 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T251521_2 - 4e-07 30.0 40.1 0.0016 18.6 0.0 9.0 9 0 0 9 9 9 3 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T251521_2 - 4.8e-05 22.9 0.7 4.8e-05 22.9 0.7 5.9 6 0 0 6 6 6 2 zinc-finger C2H2-type zf-met PF12874.5 T251521_2 - 0.00065 19.9 0.3 0.00065 19.9 0.3 8.3 8 0 0 8 8 8 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 T251521_2 - 0.0015 18.3 54.9 0.43 10.5 1.0 9.7 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_8 PF15909.3 T251521_2 - 0.002 18.2 1.7 0.002 18.2 1.7 5.0 3 2 2 5 5 5 1 C2H2-type zinc ribbon zf-C4 PF00105.16 T239271_2 - 5.7e-32 109.9 16.2 5.7e-32 109.9 16.2 2.5 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 T239271_2 - 1.2e-23 83.7 0.6 2.1e-23 82.9 0.0 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor ETF_alpha PF00766.17 T120013_3 - 3e-37 126.4 0.4 6.8e-37 125.2 0.4 1.6 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.19 T120013_3 - 1.3e-27 96.7 1.0 2.2e-27 96.0 1.0 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Collagen PF01391.16 T007081_2 - 7.4e-42 140.8 419.3 4.2e-09 35.9 25.8 16.6 9 3 7 16 16 16 8 Collagen triple helix repeat (20 copies) EF-hand_7 PF13499.4 T007081_2 - 1.2e-13 51.2 0.0 6.9e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 T007081_2 - 1.5e-13 49.1 0.0 8.9e-05 21.6 0.0 3.8 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 T007081_2 - 2e-13 49.0 0.0 1.8e-05 24.2 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 T007081_2 - 2.6e-11 42.4 0.0 0.00084 18.6 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 T007081_2 - 7.4e-06 25.5 0.0 0.0056 16.3 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain pair Collagen PF01391.16 T007081_3 - 4e-63 208.9 355.7 7.6e-09 35.1 22.0 15.8 8 3 7 15 15 15 14 Collagen triple helix repeat (20 copies) SIR2 PF02146.15 T166465_3 - 2.1e-17 63.4 0.0 2.9e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.20 T166465_3 - 0.0029 17.2 0.0 0.0044 16.6 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Miff PF05644.9 T209001_2 - 1.2e-102 343.5 10.9 1.3e-65 221.8 1.2 2.1 1 1 1 2 2 2 2 Mitochondrial and peroxisomal fission factor Mff VAD1-2 PF15310.4 T378760_2 - 0.19 11.5 2.0 0.31 10.8 2.0 1.2 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling Retrotrans_gag PF03732.15 T378760_3 - 0.00081 19.5 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4764 PF15961.3 T370789_1 - 1.7e-89 301.4 1.5 2.3e-89 301.0 1.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) DUF1725 PF08333.9 T370789_1 - 0.001 18.5 5.0 0.0019 17.7 5.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF4764 PF15961.3 T370789_2 - 5.2e-19 68.3 5.9 2.6e-11 42.9 0.2 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4764) DUF4764 PF15961.3 T370789_3 - 1.2e-06 27.4 1.2 2e-06 26.7 1.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) pKID PF02173.15 T187676_2 - 0.15 11.4 0.6 0.29 10.5 0.6 1.5 1 0 0 1 1 1 0 pKID domain VWA PF00092.26 T187676_3 - 1.4e-77 259.8 0.1 8.2e-41 140.0 0.0 2.7 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_2 PF13519.4 T187676_3 - 2.2e-31 108.5 0.0 2.3e-14 53.8 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.17 T187676_3 - 2.8e-26 91.3 0.1 6.9e-26 90.1 0.1 1.6 1 0 0 1 1 1 1 LCCL domain VWA_CoxE PF05762.12 T187676_3 - 0.00024 20.5 0.0 0.068 12.4 0.0 2.3 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein DUF1194 PF06707.9 T187676_3 - 0.00042 19.4 0.1 0.54 9.3 0.1 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF1194) Rxt3 PF08642.8 T187676_3 - 0.037 14.7 0.0 0.19 12.4 0.0 2.1 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Trypsin PF00089.24 T130681_1 - 2.3e-67 226.9 0.0 1.4e-42 145.8 0.1 2.2 2 0 0 2 2 2 2 Trypsin DUF1986 PF09342.9 T130681_1 - 4.2e-09 36.7 0.0 5.2e-05 23.5 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 T130681_1 - 3.8e-08 34.2 0.0 1.8e-05 25.6 0.0 2.5 2 0 0 2 2 2 2 Trypsin-like peptidase domain VKOR PF07884.12 T130681_2 - 1.1e-24 86.9 12.8 1.9e-24 86.1 12.8 1.4 1 0 0 1 1 1 1 Vitamin K epoxide reductase family RRM_1 PF00076.20 T266240_1 - 5.3e-21 74.1 0.0 2.2e-09 36.9 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CRAM_rpt PF07016.9 T039898_1 - 0.051 13.2 1.3 0.24 11.1 1.3 2.2 1 0 0 1 1 1 0 Cysteine-rich acidic integral membrane protein precursor Yae1_N PF09811.7 T039898_2 - 0.99 9.0 7.1 2.3 7.9 7.1 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Ig_3 PF13927.4 T245297_2 - 1.9e-77 255.7 3.3 5.5e-14 52.4 0.0 7.0 7 0 0 7 7 6 6 Immunoglobulin domain I-set PF07679.14 T245297_2 - 1.7e-75 249.0 0.0 6.8e-14 51.6 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin I-set domain ig PF00047.23 T245297_2 - 1.8e-56 188.1 1.2 4.4e-09 36.3 0.0 6.8 7 0 0 7 7 7 6 Immunoglobulin domain Ig_2 PF13895.4 T245297_2 - 6.8e-51 170.4 0.1 4.4e-09 36.4 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.19 T245297_2 - 3.4e-43 145.8 21.5 6.7e-16 58.3 1.4 4.4 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.15 T245297_2 - 2.6e-25 88.6 9.0 0.00011 22.2 0.2 10.6 6 5 1 7 7 7 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 T245297_2 - 8e-07 28.9 0.2 2.2 8.3 0.0 4.2 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.3 T245297_2 - 3e-06 27.6 11.3 0.009 16.4 0.3 3.6 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.15 T245297_2 - 9.6e-06 25.2 1.3 0.00048 19.8 0.4 2.7 2 0 0 2 2 2 1 Tissue factor fn3_2 PF16893.3 T245297_2 - 0.0024 17.9 1.6 0.031 14.3 0.1 3.2 4 0 0 4 4 4 1 Fibronectin type III domain C2-set PF05790.13 T245297_2 - 0.013 15.6 0.0 7.4 6.7 0.0 4.7 6 0 0 6 6 6 0 Immunoglobulin C2-set domain fn3_4 PF16794.3 T245297_2 - 0.044 13.6 0.3 2.6 7.8 0.1 2.8 2 0 0 2 2 2 0 Fibronectin-III type domain Herpes_gE PF02480.14 T245297_2 - 1.8 7.1 3.8 8.1 4.9 0.0 3.2 3 1 1 4 4 4 0 Alphaherpesvirus glycoprotein E Pkinase PF00069.23 T138799_1 - 5.4e-65 219.2 0.0 6.8e-65 218.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T138799_1 - 1e-30 106.8 0.0 1.4e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T138799_1 - 6.6e-06 25.5 0.1 0.0028 16.9 0.0 2.2 1 1 1 2 2 2 2 Kinase-like RIO1 PF01163.20 T138799_1 - 0.23 10.9 0.0 0.35 10.3 0.0 1.2 1 0 0 1 1 1 0 RIO1 family DUF4609 PF15382.4 T138799_3 - 2.7e-39 132.7 1.3 4.6e-39 132.0 1.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4609) Pkinase_Tyr PF07714.15 T122168_2 - 1.5e-93 312.7 0.0 2e-93 312.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T122168_2 - 4.1e-48 163.9 0.0 5.9e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 T122168_2 - 1.6e-15 56.8 0.0 2.8e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 SH2 domain FCH PF00611.21 T122168_2 - 0.00093 19.3 0.1 0.0022 18.1 0.1 1.7 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Peptidase_S8 PF00082.20 T122168_3 - 4.8e-48 163.8 5.8 4.8e-48 163.8 5.8 1.7 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.18 T122168_3 - 8.9e-28 96.0 0.0 1.8e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.3 T122168_3 - 1.2e-23 83.6 0.5 2e-23 82.8 0.5 1.4 1 0 0 1 1 1 1 Peptidase S8 pro-domain DUF357 PF04010.11 T122168_3 - 0.27 11.2 0.3 0.46 10.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF357) I-set PF07679.14 T070674_3 - 1.1e-40 137.4 0.2 1.9e-14 53.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 T070674_3 - 1.2e-35 121.9 0.6 5.6e-13 49.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T070674_3 - 2e-30 104.6 1.0 2.2e-13 50.1 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T070674_3 - 7.3e-27 93.4 0.5 5e-10 39.5 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T070674_3 - 1e-11 44.8 6.1 1.6e-06 28.1 0.1 5.1 3 2 1 4 4 4 3 Immunoglobulin V-set domain Izumo-Ig PF16706.3 T070674_3 - 6.3e-05 22.8 0.4 0.19 11.7 0.1 3.5 3 1 0 3 3 3 1 Izumo-like Immunoglobulin domain ig PF00047.23 T195563_1 - 1.6e-28 98.6 0.7 6.5e-18 64.6 0.1 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 T195563_1 - 2.5e-19 69.5 0.2 1.6e-06 28.5 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T195563_1 - 2.5e-14 53.0 0.0 0.00098 19.0 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 T195563_1 - 4.2e-14 52.5 0.1 9.4e-05 22.6 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 T195563_1 - 9.9e-06 25.6 4.2 0.28 11.2 0.2 4.9 3 2 0 3 3 3 2 Immunoglobulin V-set domain Izumo-Ig PF16706.3 T195563_1 - 0.00013 21.8 0.0 0.0034 17.3 0.0 2.4 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 T195563_1 - 0.00021 21.5 0.1 1 9.7 0.0 3.1 2 1 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain stn_TNFRSF12A PF12191.6 T195563_1 - 0.0041 17.2 0.3 0.26 11.4 0.0 2.7 3 0 0 3 3 3 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain K1377 PF15352.4 T066395_2 - 0 1545.3 63.6 0 1544.6 63.6 1.2 1 0 0 1 1 1 1 Susceptibility to monomelic amyotrophy DUF2043 PF09740.7 T259381_1 - 1.8e-38 131.4 0.1 3.1e-38 130.6 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2043) Ets PF00178.20 T302594_3 - 8.4e-27 93.3 0.8 1.4e-26 92.6 0.8 1.4 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 T302594_3 - 2.1e-22 78.8 0.0 4.8e-22 77.6 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Hyr1 PF15789.3 T301655_1 - 7.2e-15 54.1 3.2 1.4e-14 53.2 3.2 1.5 1 0 0 1 1 1 1 Hyphally regulated cell wall GPI-anchored protein 1 Transposase_22 PF02994.12 T301655_2 - 1.9e-43 148.6 12.8 2.8e-43 148.1 12.8 1.1 1 0 0 1 1 1 1 L1 transposable element MHC_II_beta PF00969.17 T301655_2 - 4.8e-33 113.0 0.1 8.6e-33 112.2 0.1 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 T301655_2 - 2.6e-22 79.0 0.0 4.9e-22 78.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ABC_membrane PF00664.21 T301655_3 - 2.1e-55 188.2 0.3 4.5e-55 187.1 0.3 1.5 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 T301655_3 - 4.8e-32 111.2 0.0 7.4e-32 110.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.4 T301655_3 - 0.0014 18.1 0.1 0.0028 17.2 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.17 T301655_3 - 0.0028 17.0 0.6 0.017 14.4 0.6 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.4 T301655_3 - 0.0057 16.3 0.8 0.018 14.6 0.8 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 T301655_3 - 0.0062 16.8 0.2 0.011 16.0 0.2 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 T301655_3 - 0.0089 16.2 0.0 0.024 14.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.4 T301655_3 - 0.024 14.3 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.4 T301655_3 - 0.087 12.3 0.3 0.24 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain Mito_carr PF00153.25 T043138_3 - 8.6e-67 221.0 6.0 9e-23 79.9 0.7 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein GSAP-16 PF14959.4 T327213_3 - 1.7e-38 130.7 0.2 3.4e-38 129.7 0.2 1.5 1 0 0 1 1 1 1 gamma-Secretase-activating protein C-term TNFR_c6 PF00020.16 T001377_1 - 5.2e-05 23.4 1.3 5.2e-05 23.4 1.3 3.3 3 0 0 3 3 3 2 TNFR/NGFR cysteine-rich region Hum_adeno_E3A PF05393.9 T001377_1 - 0.05 13.4 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein TNFR_c6 PF00020.16 T001377_2 - 0.0044 17.3 14.3 1.4 9.3 3.6 3.8 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region FLYWCH_N PF15423.4 T125765_3 - 4.3e-46 155.3 4.2 6.9e-46 154.7 4.2 1.3 1 0 0 1 1 1 1 FLYWCH-type zinc finger-containing protein Sema PF01403.17 T242785_1 - 6.1e-144 479.8 0.0 8.1e-144 479.4 0.0 1.2 1 0 0 1 1 1 1 Sema domain Ig_3 PF13927.4 T242785_1 - 0.00029 21.3 0.0 0.00069 20.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T242785_1 - 0.0013 18.7 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 T242785_1 - 0.0087 16.1 0.0 0.021 14.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain zf-HC5HC2H_2 PF13832.4 T289264_3 - 2.3e-30 104.9 8.3 2.3e-30 104.9 8.3 2.6 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 T289264_3 - 1.5e-23 82.7 8.7 1.5e-23 82.7 8.7 3.2 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.4 T289264_3 - 1.4e-12 46.7 6.6 1.4e-12 46.7 6.6 3.4 2 0 0 2 2 2 1 PHD-finger PHD PF00628.27 T289264_3 - 9.3e-10 38.1 8.8 9.3e-10 38.1 8.8 3.5 3 0 0 3 3 3 1 PHD-finger EPL1 PF10513.7 T289264_3 - 2.5e-06 27.8 0.2 6.2e-06 26.6 0.0 1.7 2 0 0 2 2 2 1 Enhancer of polycomb-like PRA-PH PF01503.15 T289264_3 - 0.37 11.1 1.1 1.1 9.6 0.8 1.9 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase LIM PF00412.20 T369052_1 - 1.8e-30 104.8 19.0 6.5e-16 58.2 2.5 2.3 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 T369052_1 - 2.1e-09 37.0 0.3 3.9e-09 36.1 0.3 1.5 1 0 0 1 1 1 1 Homeobox domain Furin-like_2 PF15913.3 T369052_1 - 0.013 15.5 4.3 0.036 14.1 4.3 1.7 1 0 0 1 1 1 0 Furin-like repeat, cysteine-rich Homeobox PF00046.27 T369052_2 - 0.00048 19.8 0.1 0.00086 18.9 0.1 1.4 1 0 0 1 1 1 1 Homeobox domain LRR_6 PF13516.4 T330364_2 - 1.3e-15 55.9 13.9 0.099 12.6 0.0 10.2 10 0 0 10 10 10 6 Leucine Rich repeat LRR_4 PF12799.5 T330364_2 - 2.8e-11 43.3 19.3 0.032 14.5 0.0 7.2 4 2 2 7 7 7 4 Leucine Rich repeats (2 copies) F-box-like PF12937.5 T330364_2 - 0.00044 19.9 0.1 0.0011 18.6 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T330364_2 - 0.026 14.3 0.1 0.026 14.3 0.1 2.3 2 0 0 2 2 2 0 F-box domain Ste50p-SAM PF09235.8 T330364_2 - 0.054 13.6 0.7 58 3.9 0.0 4.6 5 0 0 5 5 5 0 Ste50p, sterile alpha motif LRR_1 PF00560.31 T330364_2 - 1.3 9.6 20.7 33 5.4 0.5 9.4 9 2 1 10 10 10 0 Leucine Rich Repeat LRR_8 PF13855.4 T330364_2 - 1.6 8.4 12.3 26 4.5 0.2 5.0 4 2 1 5 5 5 0 Leucine rich repeat RVT_1 PF00078.25 T051433_2 - 6.6e-06 25.7 0.0 1.2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RIC3 PF15361.4 T054339_1 - 6.9e-08 32.9 0.5 1.5e-06 28.5 0.4 2.4 2 0 0 2 2 2 1 Resistance to inhibitors of cholinesterase homologue 3 RIC3 PF15361.4 T054339_2 - 1.2e-16 61.2 0.0 2.7e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 LRR_8 PF13855.4 T092534_1 - 8.8e-65 214.2 48.7 8.5e-16 57.3 1.0 5.7 2 1 5 7 7 7 7 Leucine rich repeat LRR_5 PF13306.4 T092534_1 - 1.6e-17 63.5 6.4 3.4e-09 36.6 0.9 2.6 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 T092534_1 - 3.9e-14 52.3 34.1 6.8e-05 23.0 2.1 6.6 3 1 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 T092534_1 - 9.6e-09 34.8 8.9 0.00036 19.9 1.2 2.7 1 1 2 3 3 3 2 Leucine-rich repeat Ldl_recept_a PF00057.16 T092534_1 - 8.7e-08 32.1 6.5 8.7e-08 32.1 6.5 2.2 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A 7tm_1 PF00001.19 T092534_3 - 1.3e-19 70.4 18.6 1.3e-19 70.4 18.6 1.9 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) Telethonin PF09470.8 T146802_2 - 1.8e-72 242.6 2.4 2.9e-72 241.8 2.4 1.3 1 0 0 1 1 1 1 Telethonin protein START PF01852.17 T146802_2 - 1.3e-49 168.3 0.0 1.7e-49 167.9 0.0 1.2 1 0 0 1 1 1 1 START domain DARPP-32 PF05395.10 T146802_2 - 4.9e-42 143.8 11.0 9.8e-42 142.8 11.0 1.5 1 0 0 1 1 1 1 Protein phosphatase inhibitor 1/DARPP-32 MENTAL PF10457.7 T146802_2 - 2.2e-22 79.6 0.0 3.5e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Cholesterol-capturing domain MENTAL PF10457.7 T146802_3 - 5.3e-28 97.9 4.2 7.6e-28 97.4 4.2 1.2 1 0 0 1 1 1 1 Cholesterol-capturing domain Pkinase PF00069.23 T084526_1 - 1.3e-71 240.9 0.0 1.9e-71 240.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T084526_1 - 4.5e-34 117.8 0.0 7.8e-34 117.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T084526_1 - 3.7e-05 23.0 0.0 5.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 T084526_1 - 0.0033 16.7 0.4 0.0057 15.9 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Forkhead PF00250.16 T086075_3 - 6.1e-27 93.6 0.0 1e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain PDZ PF00595.22 T382378_1 - 1.2e-16 60.7 1.5 2.5e-13 50.1 0.1 2.5 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T382378_1 - 3.8e-07 30.2 0.0 2.6e-06 27.5 0.1 2.1 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.4 T382378_1 - 0.0088 15.9 0.0 0.025 14.5 0.0 1.7 1 0 0 1 1 1 1 Tricorn protease PDZ domain Bromodomain PF00439.23 T243461_2 - 1.7e-110 361.2 32.7 1.1e-22 79.7 0.1 7.3 7 0 0 7 7 7 6 Bromodomain BAH PF01426.16 T243461_2 - 9.2e-50 167.4 3.3 3.4e-28 97.8 1.3 2.7 2 0 0 2 2 2 2 BAH domain HMG_box PF00505.17 T243461_2 - 7.9e-12 45.3 2.5 1e-11 44.9 0.0 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T243461_2 - 3.8e-07 30.5 0.0 9.6e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 HMG-box domain Glyco_transf_10 PF00852.17 T166891_2 - 1.2e-64 217.2 0.1 1.6e-64 216.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 T166891_2 - 7.9e-36 122.7 0.0 1.2e-35 122.1 0.0 1.3 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal DUF2076 PF09849.7 T166891_2 - 0.5 10.2 2.2 0.85 9.5 2.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Glyco_transf_10 PF00852.17 T166891_3 - 7.2e-67 224.4 0.5 9.6e-67 224.0 0.5 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 T166891_3 - 6.8e-32 110.1 0.0 1.2e-31 109.3 0.0 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal FYRC PF05965.12 T068310_2 - 2.1e-21 75.8 0.0 4.8e-21 74.6 0.0 1.7 1 0 0 1 1 1 1 F/Y rich C-terminus SET PF00856.26 T068310_2 - 3e-21 76.4 0.7 3e-21 76.4 0.7 3.2 4 0 0 4 4 2 1 SET domain PHD PF00628.27 T068310_2 - 1.1e-17 63.5 75.4 2.3e-08 33.6 10.7 5.4 3 1 2 5 5 5 3 PHD-finger C2-set_2 PF08205.10 T068310_2 - 5.7e-16 58.2 0.2 7.4e-14 51.5 0.0 3.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain FYRN PF05964.12 T068310_2 - 7.7e-16 57.6 0.1 1.9e-15 56.3 0.1 1.7 1 0 0 1 1 1 1 F/Y-rich N-terminus zf-CXXC PF02008.18 T068310_2 - 6.9e-13 48.3 23.6 6.9e-13 48.3 23.6 5.6 5 1 1 6 6 2 1 CXXC zinc finger domain TPR_2 PF07719.15 T068310_2 - 2.3e-06 27.2 2.8 0.013 15.5 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.26 T068310_2 - 7e-06 25.5 0.1 0.0029 17.2 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 T068310_2 - 1.7e-05 24.9 3.8 1.7e-05 24.9 3.8 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.4 T068310_2 - 0.002 18.1 2.4 0.002 18.1 2.4 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.4 T068310_2 - 0.0042 16.6 0.2 0.094 12.3 0.1 2.5 1 1 1 2 2 2 1 TPR repeat Bromodomain PF00439.23 T068310_2 - 0.0076 16.2 0.0 0.024 14.6 0.0 1.8 1 0 0 1 1 1 1 Bromodomain TPR_16 PF13432.4 T068310_2 - 0.02 15.4 14.2 0.0043 17.6 3.5 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat PHD_2 PF13831.4 T068310_2 - 0.047 13.1 28.3 0.041 13.3 2.5 4.0 3 0 0 3 3 3 0 PHD-finger TPR_10 PF13374.4 T068310_2 - 0.13 12.0 8.4 0.13 12.0 1.7 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.4 T068310_2 - 0.68 10.4 2.0 1.8 9.0 2.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3915 PF13054.4 T068310_2 - 3.5 7.5 5.6 9.9 6.0 5.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Myosin_tail_1 PF01576.17 T141479_3 - 0 1701.8 316.3 0 1701.5 316.3 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 T141479_3 - 0 1021.1 0.9 0 1021.1 0.9 2.4 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_N PF02736.17 T141479_3 - 2.6e-12 46.2 0.1 5.6e-12 45.1 0.1 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ADIP PF11559.6 T141479_3 - 0.00017 21.5 20.7 0.00017 21.5 20.7 14.4 1 1 12 14 14 14 4 Afadin- and alpha -actinin-Binding IQ PF00612.25 T141479_3 - 0.0002 20.8 0.2 0.00066 19.1 0.2 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_22 PF13401.4 T141479_3 - 0.17 12.0 0.0 0.17 12.0 0.0 4.9 4 0 0 4 4 4 0 AAA domain CUB PF00431.18 T349655_3 - 0 1082.9 0.0 9e-26 90.2 0.0 14.3 14 0 0 14 14 14 14 CUB domain Sushi PF00084.18 T349655_3 - 3.3e-250 808.9 172.6 2.6e-11 43.9 0.4 28.6 28 0 0 28 28 28 28 Sushi repeat (SCR repeat) CUB_2 PF02408.18 T349655_3 - 2e-19 69.4 18.6 0.044 13.4 0.3 12.1 13 0 0 13 13 13 7 CUB-like domain HRM PF02793.20 T349655_3 - 0.0098 16.0 69.1 1.6 8.9 0.2 14.0 13 1 1 14 14 14 7 Hormone receptor domain CAP PF00188.24 T302743_3 - 1.4e-19 71.1 0.6 2.4e-19 70.3 0.6 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CCSMST1 PF15013.4 T349253_2 - 0.19 11.8 1.1 0.48 10.5 0.2 1.9 2 0 0 2 2 2 0 CCSMST1 family Peptidase_C48 PF02902.17 T246991_2 - 1.3e-32 113.2 4.6 1.3e-32 113.2 4.6 1.7 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain TMEM215 PF15746.3 T246991_2 - 1.4 8.2 4.2 3.4 6.9 4.2 1.7 1 0 0 1 1 1 0 TMEM215 family Filamin PF00630.17 T244124_3 - 0 1218.0 43.6 4.4e-20 72.3 0.0 24.3 24 0 0 24 24 24 24 Filamin/ABP280 repeat CH PF00307.29 T244124_3 - 9.5e-38 128.6 0.3 2.8e-20 72.4 0.4 2.5 2 0 0 2 2 2 2 Calponin homology (CH) domain Y_Y_Y PF07495.11 T244124_3 - 4.1e-10 39.3 30.0 0.64 9.9 0.0 13.1 16 0 0 16 16 16 3 Y_Y_Y domain DUF5060 PF16586.3 T244124_3 - 7.9e-08 32.4 0.0 6.8 7.0 0.0 9.7 12 0 0 12 12 12 1 Domain of unknown function (DUF5060) Big_3_5 PF16640.3 T244124_3 - 2.9e-07 30.5 35.4 0.33 11.0 0.0 12.6 15 0 0 15 15 15 4 Bacterial Ig-like domain (group 3) YtkA PF13115.4 T244124_3 - 0.0002 21.7 21.7 9.1 6.8 0.1 10.9 12 0 0 12 12 12 1 YtkA-like Big_1 PF02369.14 T244124_3 - 0.00055 19.8 2.3 6.4 6.7 0.0 6.7 7 0 0 7 7 7 1 Bacterial Ig-like domain (group 1) Invasin_D3 PF09134.8 T244124_3 - 0.00058 19.4 2.4 1.4 8.6 0.0 6.2 8 0 0 8 8 8 1 Invasin, domain 3 DUF2141 PF09912.7 T244124_3 - 0.0034 17.2 2.6 56 3.6 0.0 6.4 7 0 0 7 7 7 0 Uncharacterized protein conserved in bacteria (DUF2141) Phosphodiest PF01663.20 T155850_3 - 3.7e-75 253.6 1.3 4.9e-75 253.2 1.3 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.21 T155850_3 - 2e-06 27.3 0.2 0.0013 18.0 0.0 2.2 2 0 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.16 T155850_3 - 8.9e-05 21.8 0.0 0.00014 21.2 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily CARD PF00619.19 T134358_2 - 1.3e-17 63.4 0.0 1.8e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 Caspase recruitment domain Trypan_PARP PF05887.9 T134358_2 - 0.0016 18.4 39.1 0.0016 18.4 39.1 2.6 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) Tubulin PF00091.23 T036310_3 - 1.9e-61 207.6 0.0 2.4e-61 207.2 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 T036310_3 - 3.7e-48 162.8 0.0 5.5e-48 162.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 T036310_3 - 0.0036 16.9 0.0 0.0078 15.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain MFS_1 PF07690.14 T226931_2 - 1.9e-20 73.0 13.1 1.4e-16 60.3 4.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Katanin_con80 PF13925.4 T133292_3 - 1.1e-49 168.4 0.9 3.7e-42 143.9 0.3 2.2 2 0 0 2 2 2 2 con80 domain of Katanin WD40 PF00400.30 T133292_3 - 8.3e-48 159.2 5.3 1.5e-11 44.5 0.2 7.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T133292_3 - 1.4e-17 63.6 0.0 3.2e-05 24.0 0.0 5.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T133292_3 - 0.069 12.0 0.0 0.36 9.6 0.0 2.1 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ank_2 PF12796.5 T290065_2 - 4.3e-148 482.1 36.8 5.7e-19 68.3 0.6 12.2 3 3 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T290065_2 - 1.3e-117 382.6 15.8 1.3e-09 38.3 0.1 15.7 8 3 7 16 16 16 16 Ankyrin repeats (many copies) Ank PF00023.28 T290065_2 - 1.3e-108 351.0 50.9 7e-08 32.5 0.0 24.6 24 0 0 24 24 24 22 Ankyrin repeat Ank_3 PF13606.4 T290065_2 - 1.1e-98 311.0 28.8 9.2e-05 22.4 0.0 25.5 25 0 0 25 25 25 23 Ankyrin repeat Ank_5 PF13857.4 T290065_2 - 4.8e-95 309.8 45.5 7.6e-08 32.4 0.0 20.5 6 4 15 21 21 21 20 Ankyrin repeats (many copies) KH_1 PF00013.27 T290065_2 - 1.6e-14 53.4 0.6 4.1e-14 52.0 0.6 1.8 1 0 0 1 1 1 1 KH domain eIF_4EBP PF05456.9 T290065_3 - 3e-20 72.1 0.1 6.1e-20 71.1 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Anoctamin PF04547.10 T085052_2 - 1.4e-162 541.3 12.3 1.8e-162 541.0 12.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 T085052_2 - 8.2e-73 244.7 1.4 1.3e-72 244.1 1.4 1.3 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin NHR2 PF08788.9 T138369_3 - 1.2e-35 121.0 8.6 2.2e-35 120.1 8.6 1.4 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 T138369_3 - 3.9e-34 116.4 1.5 6.7e-34 115.7 1.5 1.4 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.16 T138369_3 - 2.6e-06 27.3 18.5 2.6e-06 27.3 18.5 2.6 2 0 0 2 2 2 1 MYND finger Efg1 PF10153.7 T138369_3 - 0.14 12.4 0.4 0.29 11.4 0.4 1.4 1 0 0 1 1 1 0 rRNA-processing protein Efg1 Ashwin PF15323.4 T196046_1 - 2e-85 286.3 13.2 2.7e-85 285.8 13.2 1.2 1 0 0 1 1 1 1 Developmental protein ACOX PF01756.17 T154681_1 - 6.9e-61 204.8 1.6 6.9e-61 204.8 1.6 1.9 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.4 T154681_1 - 5.7e-35 120.5 0.1 5.7e-35 120.5 0.1 3.1 4 0 0 4 4 4 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.17 T154681_1 - 1.2e-10 41.3 0.0 2.1e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain PBP PF01161.18 T154681_2 - 6.1e-08 32.9 0.0 1.2e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Myb_Cef PF11831.6 T304445_1 - 5.3e-82 274.8 6.6 5.3e-82 274.8 6.6 2.6 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.29 T304445_1 - 5.8e-20 71.0 7.2 2e-11 43.7 1.9 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T304445_1 - 1.2e-17 63.8 5.1 3.5e-13 49.4 4.6 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.6 T304445_1 - 0.083 12.9 0.1 0.23 11.4 0.1 1.7 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain p450 PF00067.20 T317079_3 - 6.7e-103 344.8 0.0 8.8e-103 344.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.23 T189914_2 - 3.6e-17 62.4 0.0 7e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T189914_2 - 1.2e-09 37.7 0.0 2.7e-09 36.5 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase FAM194 PF14977.4 T238504_3 - 4.6e-67 225.1 0.2 9.3e-67 224.1 0.2 1.5 1 0 0 1 1 1 1 FAM194 protein DUF4078 PF13300.4 T238504_3 - 8.4e-27 93.2 12.5 8.4e-27 93.2 12.5 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4078) zf-C3HC4_2 PF13923.4 T200981_1 - 0.0052 16.5 11.0 6.4 6.6 0.2 5.1 4 0 0 4 4 4 3 Zinc finger, C3HC4 type (RING finger) Nebulin PF00880.16 T200981_2 - 0 2108.9 520.3 8.5e-09 35.1 0.0 137.7 141 0 0 141 141 141 121 Nebulin repeat Peptidase_M24 PF00557.22 T200981_2 - 1.3e-13 51.0 8.0 0.19 11.3 0.0 9.1 11 0 0 11 11 11 6 Metallopeptidase family M24 SH3_9 PF14604.4 T200981_2 - 1.5e-12 47.1 0.0 3.3e-12 45.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T200981_2 - 3e-12 45.8 0.0 1.4e-11 43.7 0.0 2.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 T200981_2 - 2.5e-05 23.8 0.0 0.00051 19.5 0.0 3.3 3 0 0 3 3 3 1 Variant SH3 domain NFRKB_winged PF14465.4 T200981_2 - 0.00017 21.6 23.1 7.2 6.7 0.1 9.5 9 0 0 9 9 9 3 NFRKB Winged Helix-like DUF1310 PF07006.9 T200981_2 - 0.00052 19.8 0.6 30 4.5 0.0 5.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1310) mTERF PF02536.12 T200981_2 - 0.004 16.1 3.7 0.0054 15.6 0.7 2.8 2 0 0 2 2 2 1 mTERF DUF1972 PF09314.9 T200981_2 - 0.51 9.8 5.2 1.5 8.2 0.7 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1972) ACAS_N PF16177.3 T200981_2 - 0.68 9.8 2.7 2.5e+02 1.6 0.1 5.0 3 0 0 3 3 3 0 Acetyl-coenzyme A synthetase N-terminus RhoGEF PF00621.18 T243969_3 - 2.7e-37 128.6 0.0 4.9e-37 127.8 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.4 T243969_3 - 6.6e-06 26.1 0.8 4.5e-05 23.4 0.8 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 T243969_3 - 0.0032 17.8 0.0 0.0069 16.7 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_13 PF16652.3 T243969_3 - 0.0057 16.4 0.2 0.028 14.2 0.1 2.1 2 1 0 2 2 2 1 Pleckstrin homology domain FF PF01846.17 T201137_2 - 6.8e-45 150.9 24.8 1.5e-15 57.0 0.5 5.9 6 0 0 6 6 6 5 FF domain WW PF00397.24 T201137_2 - 3.6e-20 71.5 15.9 3.1e-11 42.9 5.4 2.6 2 0 0 2 2 2 2 WW domain MCR_alpha PF02249.15 T201137_2 - 1.2 9.5 3.7 2.7 8.3 3.7 1.5 1 0 0 1 1 1 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain Hist_deacetyl PF00850.17 T319400_1 - 5.8e-81 272.2 1.8 6.2e-81 272.1 0.0 1.8 2 0 0 2 2 2 1 Histone deacetylase domain HDAC4_Gln PF12203.6 T319400_1 - 4.2e-31 106.8 43.7 4.2e-31 106.8 43.7 2.8 3 0 0 3 3 3 1 Glutamine rich N terminal domain of histone deacetylase 4 Myosin_head PF00063.19 T116820_2 - 2e-288 958.1 4.1 2e-288 958.1 4.1 1.5 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.17 T116820_2 - 5e-32 110.1 2.9 1.2e-31 108.9 1.5 2.5 2 0 0 2 2 2 1 DIL domain IQ PF00612.25 T116820_2 - 1.9e-24 82.9 46.8 7.8e-06 25.1 3.9 6.9 6 0 0 6 6 6 6 IQ calmodulin-binding motif Myosin_N PF02736.17 T116820_2 - 0.049 13.3 0.1 0.099 12.3 0.1 1.5 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_22 PF13401.4 T116820_2 - 0.062 13.4 0.0 0.2 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 T116820_2 - 0.24 11.6 0.0 0.24 11.6 0.0 2.6 2 1 1 3 3 3 0 AAA ATPase domain DUF1515 PF07439.9 T116820_2 - 4.4 7.2 5.8 41 4.1 0.1 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) UDPGT PF00201.16 T265917_1 - 3e-258 857.4 0.7 3.6e-258 857.2 0.7 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 T265917_1 - 4.2e-06 26.7 0.0 7e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 T265917_1 - 0.00058 19.8 0.0 0.0057 16.5 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase Family 4 SKA2 PF16740.3 T265917_1 - 0.018 14.7 0.1 0.037 13.7 0.1 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Glyco_trans_4_4 PF13579.4 T265917_1 - 0.18 12.1 0.0 0.45 10.8 0.0 1.6 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain Peptidase_C1 PF00112.21 T061427_3 - 2.4e-64 217.3 0.6 3e-64 217.0 0.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 T061427_3 - 2.3e-10 40.6 0.0 3.7e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 T061427_3 - 0.33 9.6 1.2 0.57 8.8 0.0 1.8 2 0 0 2 2 2 0 Peptidase C1-like family 7tm_1 PF00001.19 T273897_2 - 1.5e-17 63.6 6.1 1.5e-17 63.6 6.1 1.7 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.19 T273897_3 - 9.9e-16 57.6 9.8 2.1e-15 56.5 9.8 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ANAPC10 PF03256.14 T139888_1 - 1.7e-14 53.7 0.2 3e-14 52.9 0.2 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.23 T139888_1 - 0.00022 21.2 0.0 0.00043 20.3 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain EF-hand_6 PF13405.4 T139888_1 - 0.0017 18.0 0.0 0.0047 16.6 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.30 T139888_1 - 0.0022 17.3 0.1 0.0053 16.1 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 T139888_1 - 0.058 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_7 PF13499.4 T139888_1 - 0.08 13.3 0.0 0.28 11.5 0.0 1.8 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.4 T139888_1 - 0.19 11.2 0.1 0.38 10.2 0.1 1.5 1 0 0 1 1 1 0 EF hand ZZ PF00569.15 T139888_3 - 5.2e-16 58.0 16.2 5.2e-08 32.4 5.6 2.8 2 0 0 2 2 2 2 Zinc finger, ZZ type Ion_trans PF00520.29 T071666_1 - 3.7e-186 615.7 75.6 2.5e-70 236.4 21.1 3.3 3 0 0 3 3 3 3 Ion transport protein CAC1F_C PF16885.3 T071666_1 - 4.6e-37 128.4 12.3 7e-27 94.9 0.0 3.0 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 T071666_1 - 5.9e-36 122.0 0.0 1.2e-35 121.0 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 T071666_1 - 5.4e-30 103.4 0.1 1.1e-29 102.4 0.1 1.5 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 T071666_1 - 4.2e-07 28.9 26.8 3.6e-06 25.8 4.0 5.0 4 2 2 6 6 6 3 Polycystin cation channel Ion_trans PF00520.29 T071666_3 - 3.4e-49 167.1 0.2 6.2e-49 166.3 0.2 1.4 1 0 0 1 1 1 1 Ion transport protein BUD22 PF09073.8 T288003_3 - 3.8e-10 39.6 39.6 5.2e-10 39.1 2.6 2.1 1 1 1 2 2 2 2 BUD22 DUF1180 PF06679.10 T122400_1 - 3.7e-38 131.5 0.0 8.5e-38 130.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) CcmD PF04995.12 T122400_1 - 3.5 7.7 6.4 0.22 11.5 0.9 1.9 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Nucleoplasmin PF03066.13 T047654_2 - 9e-36 122.3 0.0 1.3e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain TTL PF03133.13 T237698_2 - 4.4e-84 282.0 0.0 6.6e-84 281.4 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family 53-BP1_Tudor PF09038.8 T115478_1 - 3.4e-77 256.1 0.3 5.2e-77 255.5 0.3 1.3 1 0 0 1 1 1 1 Tumour suppressor p53-binding protein-1 Tudor DUF4537 PF15057.4 T115478_1 - 0.044 13.7 0.0 0.084 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) BRCT PF00533.24 T115478_2 - 0.00049 20.3 0.0 0.2 11.9 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.3 T115478_2 - 0.025 14.3 0.1 0.12 12.1 0.0 2.3 3 0 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.3 T115478_2 - 0.026 14.8 0.4 0.2 12.0 0.3 2.3 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain RWP-RK PF02042.13 T115478_2 - 0.1 12.4 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 RWP-RK domain DUF1908 PF08926.9 T283477_1 - 5.4e-131 435.7 0.8 5.4e-131 435.7 0.8 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1908) Pkinase PF00069.23 T283477_1 - 1.6e-60 204.6 0.0 2.5e-60 203.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T283477_1 - 4.3e-26 91.6 0.0 7.3e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.22 T283477_1 - 5.7e-08 32.9 0.0 1.1e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T283477_1 - 7.3e-07 29.3 0.0 1.6e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain APH PF01636.21 T283477_1 - 8.3e-05 22.5 0.0 0.086 12.6 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Tricorn_PDZ PF14685.4 T283477_1 - 0.0017 18.2 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 Tricorn protease PDZ domain Kinase-like PF14531.4 T283477_1 - 0.0023 17.2 0.0 0.0041 16.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 T283477_1 - 0.063 12.7 0.1 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Tachystatin_B PF11478.6 T283477_1 - 0.23 11.3 4.0 0.099 12.5 0.2 2.3 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B ERM PF00769.17 T195113_1 - 0.0062 16.3 21.3 0.0062 16.3 21.3 5.7 1 1 5 6 6 6 2 Ezrin/radixin/moesin family APG6 PF04111.10 T195113_1 - 0.04 13.2 94.9 0.069 12.4 16.9 5.2 2 1 3 5 5 5 0 Autophagy protein Apg6 DUF1664 PF07889.10 T195113_1 - 0.084 12.7 67.3 0.0087 15.9 6.3 7.4 2 2 5 8 8 8 0 Protein of unknown function (DUF1664) GAS PF13851.4 T195113_1 - 0.14 11.4 99.1 0.0087 15.3 4.6 6.5 1 1 5 6 6 6 0 Growth-arrest specific micro-tubule binding Pox_A3L PF05288.9 T195113_1 - 3 7.8 8.4 0.14 12.1 0.2 3.0 3 0 0 3 3 3 0 Poxvirus A3L Protein Laminin_G_1 PF00054.21 T158221_1 - 6.4e-31 107.2 0.0 8.3e-31 106.8 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.22 T158221_1 - 1.7e-25 89.9 0.0 2.4e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.4 T158221_1 - 1.7e-06 28.1 0.0 2.5e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1080 PF06439.9 T158221_1 - 0.021 14.8 0.0 0.031 14.3 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) Nucleoside_tran PF01733.16 T304375_1 - 3e-130 434.0 7.9 4.7e-130 433.4 7.9 1.3 1 0 0 1 1 1 1 Nucleoside transporter DUF2157 PF09925.7 T304375_1 - 2.5 7.7 8.4 6.3 6.5 8.4 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) PHD_3 PF13922.4 T160671_1 - 2e-21 76.0 8.3 1e-20 73.7 8.3 2.3 1 0 0 1 1 1 1 PHD domain of transcriptional enhancer, Asx ASXH PF13919.4 T160671_1 - 0.0046 16.8 0.5 0.0099 15.8 0.5 1.5 1 0 0 1 1 1 1 Asx homology domain K_channel_TID PF07941.9 T160671_1 - 0.46 10.8 11.0 1.1 9.6 11.0 1.6 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain ASXH PF13919.4 T160671_2 - 9e-22 77.4 0.1 2e-21 76.3 0.1 1.5 1 0 0 1 1 1 1 Asx homology domain Tropomodulin PF03250.12 T020781_1 - 1.7e-51 173.8 6.1 2.4e-51 173.4 6.1 1.2 1 0 0 1 1 1 1 Tropomodulin YL1 PF05764.11 T020781_3 - 3.7e-52 177.7 14.7 4.8e-52 177.4 14.7 1.1 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.9 T020781_3 - 1.1e-11 44.2 0.6 1.8e-11 43.4 0.6 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain PH PF00169.27 T068371_1 - 4.3e-14 52.8 0.1 7.6e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 T068371_1 - 0.0004 20.5 0.1 0.00081 19.5 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 T068371_1 - 0.00063 19.7 1.0 0.0009 19.2 0.0 1.7 2 0 0 2 2 2 1 PH domain PH_11 PF15413.4 T068371_1 - 0.0077 16.5 0.7 0.015 15.6 0.7 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain DUF501 PF04417.10 T068371_1 - 0.26 10.9 1.9 0.92 9.2 1.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF501) WD40_alt PF14077.4 T068371_2 - 0.09 12.5 1.3 0.18 11.5 1.3 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif FHA PF00498.24 T068371_2 - 0.11 12.7 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 FHA domain PspA_IM30 PF04012.10 T068371_2 - 6.3 6.2 20.3 21 4.5 20.2 1.6 1 1 0 1 1 1 0 PspA/IM30 family Cnn_1N PF07989.9 T365772_3 - 1.9e-22 79.0 9.1 1.9e-22 79.0 9.1 13.0 9 3 3 12 12 12 1 Centrosomin N-terminal motif 1 Ion_trans PF00520.29 T202248_1 - 1.6e-219 724.9 93.9 4.8e-66 222.3 22.0 4.3 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.11 T202248_1 - 1.1e-55 188.8 1.9 1.1e-55 188.8 1.9 2.5 2 1 0 2 2 2 1 Sodium ion transport-associated Na_trans_cytopl PF11933.6 T202248_1 - 2.5e-49 167.9 18.3 1.2e-42 146.1 12.5 2.5 1 1 1 2 2 2 2 Cytoplasmic domain of voltage-gated Na+ ion channel PKD_channel PF08016.10 T202248_1 - 3.1e-08 32.6 73.1 0.00019 20.1 0.3 8.4 5 3 3 8 8 8 5 Polycystin cation channel GPHH PF16905.3 T202248_1 - 1.2e-05 24.9 0.0 2.6e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated ATP-synt_B PF00430.16 T202248_1 - 0.0014 18.6 5.2 0.0048 16.9 5.2 1.9 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) Tmemb_9 PF05434.9 T202248_1 - 0.088 12.5 1.6 19 4.9 0.1 3.2 2 0 0 2 2 2 0 TMEM9 IQ PF00612.25 T202248_1 - 0.16 11.7 0.3 0.42 10.4 0.3 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ion_trans PF00520.29 T202248_3 - 5.1e-22 78.2 0.7 1.3e-21 76.8 0.7 1.7 1 0 0 1 1 1 1 Ion transport protein LBP_BPI_CETP PF01273.23 T216300_3 - 1.1e-28 99.7 0.0 3.2e-28 98.3 0.0 1.7 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.15 T216300_3 - 1.9e-24 86.3 1.7 3.2e-24 85.6 0.4 1.9 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain Tetraspannin PF00335.18 T173827_3 - 1.5e-17 64.0 1.2 1.9e-17 63.6 1.2 1.1 1 0 0 1 1 1 1 Tetraspanin family zf-DBF PF07535.10 T206279_1 - 5.1e-06 26.4 1.0 5.1e-06 26.4 1.0 3.0 3 0 0 3 3 3 1 DBF zinc finger DUF3905 PF13045.4 T206279_1 - 0.15 12.0 0.5 1.9 8.4 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3905) zf-H2C2_2 PF13465.4 T308959_2 - 7e-22 76.7 54.1 1e-06 28.8 1.0 6.3 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 T308959_2 - 1.7e-09 37.5 60.2 0.00063 19.9 0.2 6.9 7 0 0 7 7 7 4 Zinc finger, C2H2 type SET PF00856.26 T308959_2 - 9.1e-08 32.5 0.1 2.8e-07 30.9 0.1 1.8 2 0 0 2 2 2 1 SET domain zf-C2H2_6 PF13912.4 T308959_2 - 2.6e-05 23.9 34.8 0.00033 20.4 3.4 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_4 PF13894.4 T308959_2 - 0.0045 17.6 52.1 0.12 13.2 4.9 7.1 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T308959_2 - 0.018 15.2 0.4 0.018 15.2 0.4 4.9 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.4 T174620_1 - 2.2e-86 280.6 92.6 9.5e-09 35.2 0.9 14.1 13 0 0 13 13 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 T174620_1 - 4.1e-38 127.6 103.4 4.9e-05 23.4 1.7 13.3 14 0 0 14 14 14 11 Zinc finger, C2H2 type KRAB PF01352.25 T174620_1 - 1.6e-24 85.2 1.1 2.8e-24 84.4 1.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T174620_1 - 1.4e-22 78.3 85.3 0.0053 17.3 1.4 12.7 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T174620_1 - 3.8e-14 52.1 63.1 0.03 14.2 0.5 11.7 11 0 0 11 11 11 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T174620_1 - 2.9e-08 33.6 55.9 0.027 14.5 3.4 7.6 3 2 7 10 10 10 9 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T174620_1 - 0.0052 17.4 40.9 0.79 10.4 2.2 6.5 4 2 1 6 6 6 4 zinc-ribbon family zf-C2H2_11 PF16622.3 T174620_1 - 0.0084 15.7 0.4 0.0084 15.7 0.4 10.7 12 0 0 12 12 12 5 zinc-finger C2H2-type XPA_N PF01286.16 T174620_1 - 0.029 14.3 49.9 5.6 7.0 0.1 11.7 12 0 0 12 12 12 0 XPA protein N-terminal GAGA PF09237.9 T174620_1 - 5 6.9 6.6 23 4.7 0.4 3.1 3 0 0 3 3 3 0 GAGA factor Lipocalin PF00061.21 T368798_1 - 2.6e-17 63.2 0.0 3.8e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.21 T368798_2 - 0.0018 18.3 0.0 0.0026 17.9 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Ribosomal_L17 PF01196.17 T054075_2 - 2.1e-23 82.9 0.0 3.5e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 Gal-bind_lectin PF00337.20 T233366_2 - 2.6e-28 98.1 0.0 4.5e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Galactoside-binding lectin FAM196 PF15265.4 T292951_1 - 3.5e-167 557.7 14.8 4.3e-167 557.4 14.8 1.1 1 0 0 1 1 1 1 FAM196 family p450 PF00067.20 T080747_1 - 1.6e-72 244.6 0.0 2.3e-59 201.2 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 p450 PF00067.20 T080747_2 - 1.4e-05 23.9 0.0 1.9e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_4 PF02390.15 T080747_3 - 4.1e-57 192.3 0.0 5.4e-57 191.9 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Troponin PF00992.18 T052921_2 - 1.6e-45 154.5 8.9 2.3e-45 154.1 8.9 1.2 1 0 0 1 1 1 1 Troponin Tup_N PF08581.8 T052921_2 - 0.019 15.1 0.8 0.039 14.1 0.8 1.5 1 0 0 1 1 1 0 Tup N-terminal DUF919 PF06034.9 T052921_2 - 0.025 14.2 0.6 0.083 12.6 0.6 1.9 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF2408 PF10303.7 T052921_2 - 0.047 14.1 4.6 0.11 12.9 4.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Lectin_N PF03954.12 T140754_1 - 3.1e-59 198.3 3.9 5.3e-59 197.5 3.9 1.3 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain Lectin_C PF00059.19 T140754_1 - 1.1e-23 83.9 1.0 1.9e-23 83.1 1.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain Tropomyosin_1 PF12718.5 T140754_1 - 0.0041 17.1 0.6 0.0072 16.3 0.6 1.3 1 0 0 1 1 1 1 Tropomyosin like IFT57 PF10498.7 T140754_1 - 0.092 11.6 1.0 0.13 11.0 1.0 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 CYSTM PF12734.5 T290034_2 - 2.3e-08 34.1 9.6 2.3e-08 34.1 9.6 2.7 2 0 0 2 2 2 1 Cysteine-rich TM module stress tolerance RhoGEF PF00621.18 T139327_1 - 6.3e-32 111.1 2.3 1.1e-31 110.4 2.3 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 T139327_1 - 4.8e-10 39.8 3.9 2.5e-09 37.4 1.2 2.8 2 1 0 2 2 2 1 PH domain C2 PF00168.28 T139327_1 - 1.5e-06 28.3 0.1 3e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 C2 domain PH_10 PF15411.4 T139327_1 - 0.069 13.3 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Phage_antiter_Q PF06323.9 T139327_1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Phage antitermination protein Q RYDR_ITPR PF01365.19 T114014_1 - 1.5e-136 452.3 14.3 1.4e-73 246.6 0.0 4.1 4 0 0 4 4 4 2 RIH domain RyR PF02026.14 T114014_1 - 1.5e-122 400.0 6.0 2.7e-33 113.8 0.0 5.1 5 0 0 5 5 5 4 RyR domain SPRY PF00622.26 T114014_1 - 3.8e-65 217.3 0.6 4.6e-20 71.8 0.0 3.8 3 0 0 3 3 3 3 SPRY domain MIR PF02815.17 T114014_1 - 1.2e-59 201.2 5.1 4.3e-55 186.3 0.0 3.4 3 0 0 3 3 3 2 MIR domain Ins145_P3_rec PF08709.9 T114014_1 - 4.3e-59 199.2 0.0 1.7e-56 190.6 0.0 3.3 2 1 1 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RR_TM4-6 PF06459.10 T114014_1 - 2.5e-57 194.7 26.8 3.1e-31 109.1 7.5 3.9 2 1 1 3 3 3 2 Ryanodine Receptor TM 4-6 RIH_assoc PF08454.9 T114014_1 - 5e-30 103.2 0.2 5e-30 103.2 0.2 4.6 4 1 0 4 4 4 1 RyR and IP3R Homology associated Ion_trans PF00520.29 T114014_1 - 9.2e-14 51.1 3.0 9.2e-14 51.1 3.0 2.3 3 0 0 3 3 3 1 Ion transport protein EF-hand_1 PF00036.30 T114014_1 - 5.8e-05 22.2 0.1 0.00027 20.1 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 T114014_1 - 0.00076 19.1 0.0 0.0051 16.5 0.0 2.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.4 T114014_1 - 0.00089 18.8 0.4 0.0042 16.7 0.4 2.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 T114014_1 - 0.043 13.2 0.2 0.13 11.7 0.0 2.0 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.4 T114014_1 - 0.056 13.8 5.8 0.019 15.3 1.1 2.9 2 0 0 2 2 2 0 EF-hand domain pair Cupin_8 PF13621.4 T129319_3 - 1.7e-34 119.6 0.0 2.4e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.10 T129319_3 - 1.2e-08 34.7 0.2 1.9e-08 34.0 0.2 1.1 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.20 T129319_3 - 0.091 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase Trypsin PF00089.24 T078611_2 - 1.4e-09 38.0 0.3 1.7e-09 37.7 0.3 1.1 1 0 0 1 1 1 1 Trypsin Dynactin PF12455.6 T192034_3 - 5e-102 340.9 4.9 5e-102 340.9 4.9 4.5 4 1 0 4 4 4 1 Dynein associated protein CAP_GLY PF01302.23 T192034_3 - 9.6e-23 79.8 2.4 2.1e-22 78.8 2.4 1.6 1 0 0 1 1 1 1 CAP-Gly domain Lebercilin PF15619.4 T192034_3 - 0.002 17.7 38.4 0.002 17.7 38.4 5.8 4 2 1 5 5 5 2 Ciliary protein causing Leber congenital amaurosis disease Filament PF00038.19 T192034_3 - 0.31 10.4 88.5 0.66 9.4 35.6 3.7 3 0 0 3 3 3 0 Intermediate filament protein IncA PF04156.12 T192034_3 - 8.6 6.0 103.9 0.11 12.2 28.2 6.1 4 2 2 6 6 6 0 IncA protein MFS_1 PF07690.14 T298986_3 - 3.8e-05 22.6 0.6 6.5e-05 21.9 0.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Eapp_C PF10238.7 T298986_3 - 5.1 7.0 8.7 9.2 6.2 8.7 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein I-set PF07679.14 T274212_2 - 2.1e-61 203.8 0.0 2.3e-22 78.7 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 T274212_2 - 1.9e-43 146.8 0.0 2.7e-13 50.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T274212_2 - 8.3e-29 99.5 0.1 5.5e-10 39.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T274212_2 - 1.2e-26 92.7 0.0 7.7e-08 32.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T274212_2 - 2.2e-11 43.8 0.1 0.038 14.0 0.0 4.6 3 1 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 T274212_2 - 3.9e-09 36.3 0.0 0.063 13.2 0.0 3.5 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.6 T274212_2 - 0.0059 16.7 0.0 0.24 11.5 0.0 2.8 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 DEAD PF00270.27 T146259_3 - 2.2e-36 125.2 0.0 3.3e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T146259_3 - 2.9e-29 101.5 0.1 1.1e-28 99.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 T146259_3 - 0.00018 21.4 0.0 0.00058 19.8 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 T146259_3 - 0.01 16.0 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain EF-hand_4 PF12763.5 T146259_3 - 0.042 13.7 0.0 0.096 12.5 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand CK1gamma_C PF12605.6 T146259_3 - 1.6 9.8 5.3 0.48 11.5 0.8 2.5 2 0 0 2 2 2 0 Casein kinase 1 gamma C terminal Mmp37 PF09139.9 T238091_2 - 4.9e-52 177.2 0.1 6.6e-52 176.8 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial matrix Mmp37 Mmp37 PF09139.9 T238091_3 - 7.3e-49 166.8 0.0 9.7e-49 166.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial matrix Mmp37 Bromodomain PF00439.23 T201699_1 - 1.2e-20 73.3 0.0 2.7e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain MBD PF01429.17 T201699_1 - 2.7e-20 71.7 0.0 5.7e-20 70.7 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain PHD PF00628.27 T201699_1 - 2.3e-11 43.3 9.2 6.9e-11 41.7 9.2 1.9 1 0 0 1 1 1 1 PHD-finger WSD PF15613.4 T201699_1 - 8.9e-11 42.0 0.1 4.5e-07 30.2 0.1 4.7 5 0 0 5 5 5 2 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.15 T201699_1 - 6.1e-09 35.9 0.3 1.3e-08 34.9 0.3 1.6 1 0 0 1 1 1 1 DDT domain RNA_pol_3_Rpc31 PF11705.6 T201699_1 - 0.0014 18.7 1.0 0.0014 18.7 1.0 6.1 5 2 0 5 5 5 1 DNA-directed RNA polymerase III subunit Rpc31 7tm_1 PF00001.19 T321756_3 - 5.5e-07 29.0 32.3 5.5e-07 29.0 32.3 3.3 3 1 0 3 3 3 1 7 transmembrane receptor (rhodopsin family) KASH PF10541.7 T174208_2 - 1.3e-11 44.4 6.1 3.5e-11 43.0 6.1 1.8 1 0 0 1 1 1 1 Nuclear envelope localisation domain CAP_GLY PF01302.23 T174208_3 - 5.5e-48 160.7 3.2 5.6e-23 80.6 0.1 2.5 2 0 0 2 2 2 2 CAP-Gly domain Ank_2 PF12796.5 T174208_3 - 6.3e-10 39.4 0.6 1.3e-07 31.9 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T174208_3 - 1.6e-05 25.2 1.1 0.018 15.5 0.2 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.28 T174208_3 - 6e-05 23.2 5.2 1.2 9.6 0.7 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.4 T174208_3 - 6.1e-05 23.1 5.5 0.23 11.8 0.1 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 T174208_3 - 0.00095 19.3 2.2 13 6.6 0.3 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.5 T301227_1 - 3.7e-38 129.9 2.4 4.7e-13 49.4 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 T301227_1 - 1.2e-32 110.8 5.0 2.6e-06 27.5 0.1 6.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.4 T301227_1 - 3e-30 104.1 4.4 6.6e-12 45.6 0.0 4.1 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 T301227_1 - 3.3e-26 90.8 10.1 2.1e-07 31.0 0.0 7.1 2 1 5 7 7 7 6 Ankyrin repeats (many copies) SET PF00856.26 T301227_1 - 8e-25 88.0 0.4 3e-23 82.9 0.1 2.4 2 0 0 2 2 2 1 SET domain Ank_3 PF13606.4 T301227_1 - 2.3e-23 79.6 5.0 0.002 18.3 0.0 6.7 6 0 0 6 6 6 5 Ankyrin repeat Pre-SET PF05033.14 T301227_1 - 9.8e-15 55.0 14.9 9.8e-15 55.0 14.9 2.9 3 0 0 3 3 2 1 Pre-SET motif CDC45 PF02724.12 T301227_1 - 0.0011 17.2 14.1 0.0017 16.7 14.1 1.1 1 0 0 1 1 1 1 CDC45-like protein Paf1 PF03985.11 T301227_1 - 0.079 11.8 16.1 0.11 11.3 16.1 1.1 1 0 0 1 1 1 0 Paf1 RNA_pol_3_Rpc31 PF11705.6 T301227_1 - 0.12 12.4 14.6 0.23 11.5 14.6 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.10 T301227_1 - 0.46 8.5 18.5 0.66 8.0 18.5 1.1 1 0 0 1 1 1 0 Nop14-like family AAA_23 PF13476.4 T301227_1 - 0.74 10.1 5.8 1.2 9.5 5.8 1.2 1 0 0 1 1 1 0 AAA domain XRCC4 PF06632.10 T301227_1 - 0.97 8.1 13.4 1.5 7.4 13.4 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 SDA1 PF05285.10 T301227_1 - 3.5 6.8 22.8 5.6 6.2 22.8 1.2 1 0 0 1 1 1 0 SDA1 Choline_transpo PF04515.10 T301227_3 - 4.1e-108 361.3 32.4 6.7e-108 360.6 27.7 2.3 2 0 0 2 2 2 2 Plasma-membrane choline transporter SR-25 PF10500.7 T088257_3 - 2.6e-102 341.1 50.9 3.7e-102 340.6 50.9 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.7 T088257_3 - 0.27 9.6 21.1 0.39 9.1 21.1 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF1777 PF08648.10 T088257_3 - 1.6 8.8 35.8 3.1 7.9 35.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) Lectin_C PF00059.19 T169972_2 - 5.4e-06 27.0 0.4 1e-05 26.1 0.4 1.4 1 0 0 1 1 1 1 Lectin C-type domain DUF4680 PF15730.3 T188343_1 - 4.3 7.5 5.5 0.28 11.4 0.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4680) TTL PF03133.13 T149906_1 - 4e-83 278.8 1.5 4.5e-81 272.1 1.5 2.3 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 T149906_1 - 6.7e-07 28.7 0.0 0.00017 20.8 0.0 2.5 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 T149906_1 - 1.6e-05 24.2 0.0 0.077 12.1 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.12 T149906_1 - 0.015 15.2 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain SH2 PF00017.22 T193038_2 - 1.9e-07 30.9 0.0 3.1e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 SH2 domain RS4NT PF08071.10 T193038_2 - 0.019 15.0 0.0 0.064 13.2 0.0 2.0 1 0 0 1 1 1 0 RS4NT (NUC023) domain PNRC PF15365.4 T193038_2 - 0.036 14.5 0.9 7.7 7.0 0.8 3.0 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator zf-C3HC4_3 PF13920.4 T293346_3 - 9.1e-14 50.9 13.3 3.4e-13 49.1 13.3 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 T293346_3 - 0.0004 20.0 12.6 0.0012 18.5 12.6 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DnaJ_C PF01556.16 T063748_2 - 2.1e-33 115.4 0.0 3.5e-33 114.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 T063748_2 - 4.5e-21 74.6 0.3 7.3e-21 73.9 0.3 1.3 1 0 0 1 1 1 1 DnaJ domain OLF PF02191.14 T116699_2 - 3.1e-56 190.6 1.0 4.2e-56 190.1 1.0 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain Collagen PF01391.16 T116699_3 - 1.7e-08 33.9 41.2 4.6e-06 26.2 13.5 2.5 3 0 0 3 3 3 2 Collagen triple helix repeat (20 copies) OLF PF02191.14 T116699_3 - 0.062 12.7 0.0 0.088 12.2 0.0 1.1 1 0 0 1 1 1 0 Olfactomedin-like domain LRR_6 PF13516.4 T003365_2 - 0.081 12.9 1.4 1.3e+02 2.9 0.0 5.0 4 0 0 4 4 4 0 Leucine Rich repeat LRR_4 PF12799.5 T003365_2 - 1.3 9.4 26.1 8.1 6.9 0.3 7.3 5 3 5 10 10 10 0 Leucine Rich repeats (2 copies) zf-C2H2 PF00096.24 T003441_1 - 1.1e-08 34.9 23.1 0.055 13.8 1.9 6.3 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T003441_1 - 1.8e-08 34.3 29.8 0.15 12.8 0.2 6.9 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T003441_1 - 6.7e-05 22.6 14.8 0.0087 15.9 0.1 4.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-Di19 PF05605.10 T003441_1 - 0.012 15.7 11.8 7.6 6.8 0.1 3.8 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.3 T003441_1 - 0.051 13.2 0.1 0.051 13.2 0.1 4.9 7 0 0 7 7 7 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.4 T003441_1 - 0.63 10.5 19.7 1.2 9.6 0.2 5.4 6 0 0 6 6 6 0 Zinc-finger double domain SET PF00856.26 T003441_3 - 3.4e-08 33.9 3.6 4.6e-08 33.5 0.0 2.6 2 2 0 2 2 2 1 SET domain GET2 PF08690.8 T003441_3 - 0.018 14.6 0.1 0.027 14.0 0.1 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 CENP-B_dimeris PF09026.8 T003441_3 - 0.24 11.7 6.1 0.46 10.8 6.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TMC PF07810.11 T180688_1 - 1e-41 141.8 1.1 2.3e-41 140.7 1.1 1.6 1 0 0 1 1 1 1 TMC domain Cir_N PF10197.7 T180688_1 - 1.3e-06 28.3 8.1 1.3e-06 28.3 8.1 3.4 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR ELYS-bb PF16687.3 T034701_2 - 0 1020.0 0.4 0 1019.2 0.0 1.5 2 0 0 2 2 2 1 beta-propeller of ELYS nucleoporin ELYS PF13934.4 T034701_2 - 5.1e-54 183.4 0.0 7.9e-54 182.8 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore complex assembly HECT PF00632.23 T102506_1 - 3e-73 246.9 0.0 6.5e-73 245.8 0.0 1.5 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Sad1_UNC PF07738.11 T102506_1 - 3.6e-24 85.2 0.0 6.4e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal MIB_HERC2 PF06701.11 T102506_1 - 2.1e-23 82.2 2.6 4.6e-23 81.1 2.6 1.6 1 0 0 1 1 1 1 Mib_herc2 Ank_2 PF12796.5 T102506_1 - 3.7e-18 65.7 0.0 5.9e-10 39.5 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T102506_1 - 4.3e-10 39.5 0.0 5e-07 29.8 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 T102506_1 - 5.1e-08 33.2 0.0 5.6e-06 26.7 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 T102506_1 - 7.6e-08 31.9 0.0 0.092 13.2 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.28 T102506_1 - 1.5e-07 31.5 0.0 0.0005 20.3 0.0 4.1 4 0 0 4 4 3 1 Ankyrin repeat F5_F8_type_C PF00754.23 T102506_1 - 1.6e-05 24.9 0.1 3.7e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 F5/8 type C domain Arm PF00514.21 T102506_1 - 1.5 8.8 5.5 33 4.6 0.0 4.7 6 0 0 6 6 4 0 Armadillo/beta-catenin-like repeat Cwf_Cwc_15 PF04889.10 T102506_1 - 2.7 7.5 11.0 0.05 13.2 1.5 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PH PF00169.27 T192199_2 - 7.1e-09 36.0 0.0 1e-08 35.5 0.0 1.2 1 0 0 1 1 1 1 PH domain HemS PF05171.10 T192199_2 - 0.19 11.6 0.0 0.35 10.7 0.0 1.3 1 0 0 1 1 1 0 Haemin-degrading HemS.ChuX domain IRS PF02174.15 T192199_3 - 6.5e-14 51.5 0.0 1.1e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 PTB domain (IRS-1 type) Defensin_beta_2 PF13841.4 T335132_2 - 9.7 6.6 9.0 28 5.2 0.3 3.9 3 0 0 3 3 3 0 Beta defensin Laminin_G_2 PF02210.22 T335132_3 - 1.9e-92 306.3 6.3 8.2e-24 84.5 0.2 4.3 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.21 T335132_3 - 2.2e-64 215.4 0.7 2.9e-17 63.0 0.1 4.3 4 0 0 4 4 4 4 Laminin G domain F5_F8_type_C PF00754.23 T335132_3 - 6.2e-32 110.3 0.9 2.2e-31 108.5 0.8 2.0 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_3 PF13385.4 T335132_3 - 1.2e-10 41.6 0.5 0.0016 18.4 0.0 3.4 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 T335132_3 - 0.00014 21.9 37.9 0.0003 20.9 7.8 4.1 3 0 0 3 3 3 2 EGF-like domain COLFI PF01410.16 T335132_3 - 0.00021 20.5 0.2 0.00041 19.6 0.2 1.3 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Syndecan PF01034.18 T335132_3 - 0.074 12.9 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain hEGF PF12661.5 T335132_3 - 7.7 7.2 31.2 0.038 14.6 2.1 4.3 4 0 0 4 4 4 0 Human growth factor-like EGF Trypsin PF00089.24 T294285_3 - 2.8e-63 213.5 0.0 4.2e-63 213.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 T294285_3 - 5.9e-24 84.0 3.1 5.9e-24 84.0 3.1 3.1 4 0 0 4 4 4 1 Kringle domain EGF PF00008.25 T294285_3 - 1e-11 44.7 35.8 5.5e-08 32.8 6.8 4.1 4 0 0 4 4 4 2 EGF-like domain fn1 PF00039.16 T294285_3 - 3e-10 40.0 0.4 9.5e-10 38.4 0.4 2.0 1 0 0 1 1 1 1 Fibronectin type I domain fn2 PF00040.17 T294285_3 - 8.2e-10 38.7 15.6 0.00012 22.2 2.8 3.7 3 0 0 3 3 3 2 Fibronectin type II domain Trypsin_2 PF13365.4 T294285_3 - 8.5e-08 33.1 0.2 3.9e-06 27.7 0.0 2.5 2 0 0 2 2 2 1 Trypsin-like peptidase domain EGF_2 PF07974.11 T294285_3 - 0.00066 19.9 29.9 0.011 15.9 7.0 3.8 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.5 T294285_3 - 0.0044 17.5 3.3 0.0044 17.5 3.3 4.7 5 0 0 5 5 5 2 Human growth factor-like EGF DUF1986 PF09342.9 T294285_3 - 0.015 15.5 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Xlink PF00193.15 T057080_2 - 3.4e-18 65.7 0.0 7.7e-18 64.5 0.0 1.7 1 0 0 1 1 1 1 Extracellular link domain LRR_9 PF14580.4 T105343_1 - 3.5e-29 101.4 22.3 1e-10 41.2 0.7 5.3 2 2 3 5 5 5 5 Leucine-rich repeat LRR_4 PF12799.5 T105343_1 - 3.5e-21 74.7 58.6 3.7e-05 23.8 4.5 9.2 7 2 3 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T105343_1 - 7.6e-19 67.1 50.9 3.7e-09 36.1 1.5 6.6 5 2 2 7 7 7 5 Leucine rich repeat LRR_4 PF12799.5 T105343_3 - 1.4e-22 79.2 42.1 1.3e-07 31.6 3.4 7.2 3 2 8 11 11 11 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T105343_3 - 5.1e-14 51.6 39.6 2.7e-06 26.9 9.3 5.7 5 1 1 6 6 6 4 Leucine rich repeat LRR_9 PF14580.4 T105343_3 - 1.5e-12 47.2 16.9 1.5e-08 34.2 6.2 4.6 2 2 2 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.4 T105343_3 - 7.9 6.7 32.5 0.26 11.3 0.1 7.8 9 0 0 9 9 9 0 Leucine Rich repeat Pkinase PF00069.23 T079280_3 - 9.6e-05 21.7 0.0 0.00014 21.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T079280_3 - 0.00016 21.0 0.0 0.00021 20.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 T079280_3 - 0.1 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family BPS PF08947.8 T323950_1 - 2e-28 97.8 0.7 4.1e-28 96.8 0.7 1.5 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 T323950_1 - 2.3e-13 49.9 0.0 4.2e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 T323950_1 - 2.3e-10 40.8 0.2 5e-10 39.7 0.2 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 T323950_1 - 4.9e-09 36.5 0.9 7.4e-09 35.9 0.1 1.8 2 0 0 2 2 2 1 PH domain RRM_1 PF00076.20 T168645_1 - 1.5e-62 207.2 0.1 5.5e-20 70.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 T168645_1 - 4e-12 45.7 0.0 0.00011 21.7 0.0 3.2 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 T168645_1 - 0.017 14.9 0.0 2.5 7.9 0.0 3.0 3 0 0 3 3 3 0 Occluded RNA-recognition motif Eapp_C PF10238.7 T168645_1 - 8.5 6.3 7.6 2.3 8.2 0.4 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein GRP PF07172.9 T168645_3 - 1.2 9.7 6.2 2 9.0 0.5 3.0 2 0 0 2 2 2 0 Glycine rich protein family Sema PF01403.17 T333535_3 - 1.6e-70 237.9 0.0 2.1e-70 237.5 0.0 1.1 1 0 0 1 1 1 1 Sema domain Gelsolin PF00626.20 T080793_1 - 2.8e-92 302.6 0.0 2.1e-17 62.6 0.0 6.5 6 0 0 6 6 6 6 Gelsolin repeat NIF PF03031.16 T080793_1 - 3.2e-51 173.0 0.0 5.3e-51 172.3 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase VHP PF02209.17 T080793_1 - 1.1e-15 57.2 0.1 2.4e-15 56.2 0.1 1.6 1 0 0 1 1 1 1 Villin headpiece domain zf-C4 PF00105.16 T235426_1 - 6.6e-27 93.6 16.1 6.6e-27 93.6 16.1 2.2 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 T235426_1 - 1.1e-12 47.8 0.1 2e-12 47.0 0.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor C2 PF00168.28 T124932_1 - 1e-30 105.9 0.0 2.7e-14 53.2 0.0 3.9 3 1 0 3 3 3 2 C2 domain Membr_traf_MHD PF10540.7 T124932_1 - 1.5e-15 57.6 3.6 6.5e-07 29.6 0.0 2.7 2 1 1 3 3 3 2 Munc13 (mammalian uncoordinated) homology domain zf-DHHC PF01529.18 T082751_2 - 1.6e-34 118.7 21.2 1.6e-34 118.7 21.2 3.6 5 0 0 5 5 5 1 DHHC palmitoyltransferase BTB PF00651.29 T085801_3 - 1.3e-21 76.8 0.2 1.1e-20 73.8 0.1 2.4 1 1 1 2 2 2 1 BTB/POZ domain Ank_2 PF12796.5 T085801_3 - 1.7e-17 63.7 0.0 1.2e-08 35.2 0.0 3.5 2 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T085801_3 - 4e-16 57.4 0.2 7.1e-05 22.8 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.4 T085801_3 - 1.5e-13 50.6 0.2 0.0089 16.3 0.0 4.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 T085801_3 - 3.5e-13 49.2 0.2 1.4e-05 25.2 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.4 T085801_3 - 1e-12 48.2 0.0 1.1e-07 32.2 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) BACK PF07707.13 T085801_3 - 0.0073 16.2 0.0 0.021 14.8 0.0 1.8 1 0 0 1 1 1 1 BTB And C-terminal Kelch WD40 PF00400.30 T006322_1 - 1.1e-21 76.6 5.7 2.9e-06 27.8 0.1 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat TPR_19 PF14559.4 T006322_1 - 1.1e-07 32.1 1.5 0.0048 17.3 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.15 T006322_1 - 2.8e-06 26.9 7.5 0.073 13.1 0.4 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.26 T006322_1 - 3.3e-06 26.5 9.2 0.091 12.5 0.1 4.3 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 T006322_1 - 1e-05 25.8 0.7 0.22 12.3 0.3 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat ANAPC4_WD40 PF12894.5 T006322_1 - 2.9e-05 24.2 0.1 0.011 15.9 0.2 4.1 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_11 PF13414.4 T006322_1 - 7.4e-05 22.2 0.8 0.00033 20.1 0.5 2.0 2 0 0 2 2 2 1 TPR repeat ANAPC3 PF12895.5 T006322_1 - 0.0002 21.3 4.7 0.00036 20.5 4.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 T006322_1 - 0.00041 20.7 0.4 0.46 11.1 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.4 T006322_1 - 0.00048 20.2 1.2 1.3 9.5 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.4 T006322_1 - 0.038 14.6 4.4 1.6 9.4 1.8 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.4 T006322_1 - 0.081 13.0 1.0 3 7.9 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 T006322_1 - 0.15 12.2 0.4 16 5.9 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat AAA_12 PF13087.4 T236224_1 - 5.4e-44 150.1 0.0 8.2e-44 149.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.4 T236224_1 - 4.1e-31 108.5 0.4 2e-15 57.1 0.0 2.4 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.4 T236224_1 - 5.1e-12 45.8 0.0 9.3e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.4 T236224_1 - 3.7e-06 27.2 0.0 1.7e-05 25.1 0.0 2.1 1 1 1 2 2 2 1 AAA domain ResIII PF04851.13 T236224_1 - 0.0064 16.4 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA PF00004.27 T236224_1 - 0.062 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 T236224_1 - 0.085 13.0 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Nramp PF01566.16 T078519_3 - 7.2e-119 396.8 13.6 1.1e-118 396.3 13.6 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Lipase PF00151.17 T049114_1 - 6.1e-100 334.7 0.0 8.4e-100 334.2 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 T049114_1 - 6.4e-05 23.4 0.1 0.00012 22.5 0.1 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 T049114_1 - 0.0061 17.1 0.0 0.0097 16.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipocalin PF00061.21 T369767_1 - 1.8e-42 144.8 0.0 1.4e-33 115.9 0.0 2.1 2 0 0 2 2 2 2 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 T369767_1 - 0.016 14.9 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Triabin PI-PLC-X PF00388.17 T207723_1 - 1.2e-64 216.2 0.0 1.8e-64 215.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain EF-hand_like PF09279.9 T207723_1 - 1.8e-34 118.0 0.2 1.8e-34 118.0 0.2 1.9 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_10 PF14788.4 T207723_1 - 3.1e-23 81.2 0.5 7.1e-23 80.1 0.5 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.4 T207723_1 - 2e-08 34.5 7.6 4.5e-06 26.9 0.3 3.1 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.30 T207723_1 - 3.5e-08 32.3 0.1 0.0037 16.6 0.0 2.8 2 0 0 2 2 2 2 EF hand PH PF00169.27 T207723_1 - 5.3e-07 30.0 0.0 1.1e-06 28.9 0.0 1.5 1 0 0 1 1 1 1 PH domain EF-hand_5 PF13202.4 T207723_1 - 5.3e-07 28.7 0.3 0.0021 17.4 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T207723_1 - 5.9e-07 28.8 2.5 0.067 13.0 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain PI-PLC-Y PF00387.17 T207723_1 - 2.2e-05 24.7 0.1 4.4e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain GDPD PF03009.15 T207723_1 - 0.0043 16.7 0.0 0.0077 15.9 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family EF-hand_8 PF13833.4 T207723_1 - 0.0062 16.2 0.5 0.015 14.9 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain pair PH_12 PF16457.3 T207723_1 - 0.0068 16.8 0.1 0.017 15.5 0.1 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain Wap1 PF16997.3 T207723_1 - 0.029 13.4 0.1 0.045 12.8 0.1 1.2 1 0 0 1 1 1 0 Wap1 domain PI-PLC-Y PF00387.17 T207723_2 - 1e-31 109.6 0.1 1.8e-31 108.8 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.28 T207723_2 - 3.4e-16 59.3 0.0 6.8e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 C2 domain FtsJ PF01728.17 T317426_1 - 2.3e-15 57.0 0.0 3.8e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MAD PF05557.11 T317426_3 - 3.8e-276 917.6 92.1 4.7e-276 917.3 92.1 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein FtsJ PF01728.17 T317426_3 - 4.2e-23 82.2 0.0 9.7e-23 81.0 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF4200 PF13863.4 T317426_3 - 0.004 17.4 4.1 0.004 17.4 4.1 6.4 4 2 1 5 5 5 1 Domain of unknown function (DUF4200) Reo_sigmaC PF04582.10 T317426_3 - 3.9 6.7 14.7 0.23 10.7 1.9 3.3 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Pro_isomerase PF00160.19 T240944_1 - 6.2e-09 36.2 0.0 1.2e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pro_isomerase PF00160.19 T240944_3 - 2.4e-27 96.0 0.1 4e-27 95.3 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD BTB PF00651.29 T240944_3 - 1.9e-21 76.2 0.2 2.9e-21 75.6 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 T240944_3 - 2.1e-21 75.0 62.8 0.00018 21.7 1.5 10.4 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T240944_3 - 1.3e-15 56.9 65.9 2.5e-06 27.5 1.3 9.9 9 1 0 9 9 9 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 T240944_3 - 7e-12 45.0 67.0 0.0021 18.6 0.7 11.2 10 0 0 10 10 10 7 C2H2-type zinc finger SDA1 PF05285.10 T240944_3 - 0.72 9.1 29.9 1.1 8.5 29.9 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.10 T240944_3 - 0.86 7.6 29.3 1.3 7.1 29.3 1.0 1 0 0 1 1 1 0 Nop14-like family zf-C2H2_6 PF13912.4 T240944_3 - 7.5 6.5 46.1 0.22 11.4 0.1 9.0 8 0 0 8 8 8 0 C2H2-type zinc finger Scs3p PF10261.7 T218286_3 - 1.9e-23 83.1 17.7 9e-21 74.4 17.7 2.2 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.19 T218286_3 - 0.0003 20.4 7.0 0.0003 20.4 7.0 2.0 1 1 1 2 2 2 1 PAP2 superfamily Lipocalin PF00061.21 T369643_1 - 1.4e-05 25.2 0.0 2e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family zf-H2C2_2 PF13465.4 T176673_1 - 1.2e-99 322.5 151.7 2.6e-08 33.8 0.7 19.4 20 0 0 20 20 20 17 Zinc-finger double domain zf-C2H2 PF00096.24 T176673_1 - 6.5e-39 130.1 112.2 0.00044 20.4 0.9 17.3 16 0 0 16 16 16 15 Zinc finger, C2H2 type RVT_1 PF00078.25 T176673_1 - 1e-23 83.9 0.5 1.9e-23 83.1 0.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_6 PF13912.4 T176673_1 - 2.7e-15 55.7 123.4 0.03 14.2 1.6 16.0 16 0 0 16 16 16 12 C2H2-type zinc finger zf-C2H2_4 PF13894.4 T176673_1 - 2.5e-09 37.0 148.4 0.14 12.9 0.7 18.5 19 0 0 19 19 19 13 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T176673_1 - 1.9 8.6 91.9 0.36 10.8 2.5 9.4 6 2 4 11 11 11 0 Zinc ribbon domain KRAB PF01352.25 T176673_2 - 2.7e-25 87.6 0.3 5e-25 86.8 0.3 1.5 1 0 0 1 1 1 1 KRAB box HPIP PF15226.4 T125995_2 - 8.9e-60 200.8 10.4 4.3e-53 179.2 6.5 3.8 2 1 1 3 3 3 2 HCF-1 beta-propeller-interacting protein family PDZ PF00595.22 T156090_1 - 0.006 16.8 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Y_phosphatase PF00102.25 T156090_1 - 0.11 11.8 1.1 0.19 11.1 1.1 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase APG6 PF04111.10 T156090_1 - 2.7 7.1 29.1 1.5 8.0 21.2 2.2 1 1 1 2 2 2 0 Autophagy protein Apg6 KASH_CCD PF14662.4 T156090_1 - 3.8 7.2 28.2 83 2.8 28.2 2.2 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF3584 PF12128.6 T156090_1 - 6.8 3.9 24.3 9.7 3.4 24.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Seryl_tRNA_N PF02403.20 T156090_1 - 9.6 6.4 15.5 0.083 13.0 4.0 2.4 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Guanylate_kin PF00625.19 T156090_2 - 6.1e-05 22.6 0.0 9.6e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase Glyco_transf_64 PF09258.8 T006002_2 - 1.1e-79 267.1 0.0 1.4e-79 266.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.13 T006002_2 - 5.9e-13 48.6 0.0 1.8e-12 47.0 0.0 1.6 1 1 0 1 1 1 1 Exostosin family Anoctamin PF04547.10 T056252_1 - 3.4e-158 526.9 18.2 5.6e-158 526.2 18.2 1.4 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 T056252_1 - 6.9e-71 238.4 0.4 1.1e-70 237.8 0.4 1.3 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Wtap PF17098.3 T314516_1 - 4.4e-52 176.0 25.3 1.4e-27 96.4 4.5 2.9 3 0 0 3 3 3 2 WTAP/Mum2p family Thiolase_N PF00108.21 T314516_2 - 1.1e-92 309.9 0.9 1.4e-92 309.6 0.9 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 T314516_2 - 2.5e-39 133.6 0.1 4.3e-39 132.8 0.1 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 T314516_2 - 0.0034 16.9 1.9 0.084 12.3 1.9 2.4 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Lectin_C PF00059.19 T334293_1 - 5.5e-07 30.2 0.0 1.1e-06 29.2 0.0 1.6 1 0 0 1 1 1 1 Lectin C-type domain Integrin_alpha2 PF08441.10 T150265_3 - 8.9e-94 314.9 0.0 1.1e-93 314.5 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha BCDHK_Adom3 PF10436.7 T150265_3 - 2.9e-53 179.9 0.0 4.3e-53 179.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase FG-GAP PF01839.21 T150265_3 - 5.8e-20 71.0 11.4 7.9e-10 38.6 0.2 4.3 4 0 0 4 4 4 3 FG-GAP repeat HATPase_c PF02518.24 T150265_3 - 3.5e-11 43.5 0.0 6.3e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase VCBS PF13517.4 T150265_3 - 1.1e-09 38.6 6.5 1.5e-07 31.7 0.3 2.5 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 T150265_3 - 0.0017 18.4 4.8 4.7 7.4 0.5 3.7 3 0 0 3 3 3 2 FG-GAP repeat MTABC_N PF16185.3 T150265_3 - 0.04 13.3 0.1 0.066 12.6 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region Integrin_alpha PF00357.18 T150265_3 - 0.044 13.6 1.5 0.18 11.7 1.5 2.1 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region Guanylate_cyc PF00211.18 T323091_1 - 6.2e-127 420.2 0.4 3.2e-64 215.8 0.1 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.3 T323091_1 - 9.1e-28 97.4 0.1 9.1e-28 97.4 0.1 2.3 2 1 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.12 T323091_1 - 0.079 13.4 0.4 0.13 12.7 0.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) Ank_2 PF12796.5 T111186_1 - 2.7e-16 59.8 0.0 5e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T111186_1 - 8.6e-14 51.6 0.2 3.5e-08 33.7 0.3 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) SH3_1 PF00018.26 T111186_1 - 1.2e-12 47.0 0.7 1.2e-12 47.0 0.7 1.9 2 0 0 2 2 2 1 SH3 domain Ank PF00023.28 T111186_1 - 7.9e-12 44.9 1.0 3e-05 24.1 0.2 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 T111186_1 - 8.3e-12 44.1 0.4 4.7e-05 23.3 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat SH3_9 PF14604.4 T111186_1 - 4.3e-10 39.2 2.2 5e-10 38.9 0.2 2.1 2 0 0 2 2 2 1 Variant SH3 domain Ank_5 PF13857.4 T111186_1 - 1.8e-08 34.4 0.2 4.2e-07 30.0 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_2 PF07653.15 T111186_1 - 2.2e-08 33.5 0.0 5.5e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Antifungal_pept PF11410.6 T111186_3 - 0.024 14.4 2.7 0.096 12.5 2.7 2.0 1 0 0 1 1 1 0 Antifungal peptide Collagen PF01391.16 T301796_3 - 4.5e-151 490.6 715.8 7.5e-09 35.1 27.3 25.0 6 1 14 20 20 20 13 Collagen triple helix repeat (20 copies) COLFI PF01410.16 T301796_3 - 2.3e-58 197.1 0.0 2.5e-34 118.5 0.1 2.3 1 1 1 2 2 2 2 Fibrillar collagen C-terminal domain Hormone_recep PF00104.28 T301796_3 - 8.2e-39 133.2 0.0 1.1e-38 132.7 0.0 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 T301796_3 - 5.8e-31 106.6 16.7 1.2e-30 105.6 16.7 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Laminin_G_2 PF02210.22 T301796_3 - 3.1e-07 30.9 0.0 5.4e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Nuc_recep-AF1 PF11825.6 T301796_3 - 1.3e-05 25.1 11.8 2.8e-05 24.0 11.8 1.5 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 Laminin_G_3 PF13385.4 T301796_3 - 0.00036 20.6 0.0 0.00056 20.0 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.21 T301796_3 - 0.0096 16.0 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Fez1 PF06818.13 T339982_1 - 6.1e-45 154.0 48.5 2.4e-31 109.6 11.8 3.2 2 1 1 3 3 3 3 Fez1 Macoilin PF09726.7 T339982_1 - 0.41 9.0 17.8 0.65 8.3 17.8 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF1725 PF08333.9 T215271_2 - 0.0012 18.3 1.0 0.0025 17.3 1.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Cathelicidins PF00666.15 T215271_2 - 0.018 15.2 0.1 0.033 14.3 0.1 1.4 1 0 0 1 1 1 0 Cathelicidin Cystatin PF00031.19 T215271_2 - 0.023 14.8 0.0 0.047 13.8 0.0 1.4 1 0 0 1 1 1 0 Cystatin domain Nucleoside_tran PF01733.16 T061652_1 - 4.4e-54 183.8 0.6 7.1e-43 147.0 0.0 2.1 2 0 0 2 2 2 2 Nucleoside transporter DUF2070 PF09843.7 T061652_1 - 1.1 7.3 12.7 1.6 6.8 12.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Nucleoside_tran PF01733.16 T061652_2 - 3e-06 26.7 0.3 4.4e-06 26.2 0.3 1.1 1 0 0 1 1 1 1 Nucleoside transporter Ysc84 PF04366.10 T182729_1 - 1.2e-34 118.6 0.0 1.8e-34 118.1 0.0 1.2 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.26 T182729_1 - 6.3e-15 54.4 0.0 1.2e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T182729_1 - 2.1e-14 53.0 0.0 3.3e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T182729_1 - 2.4e-10 39.8 0.0 4.1e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain zf-C2HC PF01530.16 T183204_2 - 1.7e-44 149.5 36.4 2.2e-15 56.4 7.3 3.7 3 0 0 3 3 3 3 Zinc finger, C2HC type DUF812 PF05667.9 T183204_2 - 0.0019 17.0 7.4 0.0028 16.5 7.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) ATG16 PF08614.9 T183204_2 - 0.0027 17.8 5.9 0.0044 17.1 5.9 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) APG6 PF04111.10 T183204_2 - 0.0061 15.9 7.5 0.0096 15.2 7.5 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 CALCOCO1 PF07888.9 T183204_2 - 0.053 12.0 7.5 0.077 11.4 7.5 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF342 PF03961.11 T183204_2 - 0.062 11.8 7.7 0.091 11.2 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TBPIP PF07106.11 T183204_2 - 0.12 12.1 8.1 0.21 11.2 8.1 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Tho2 PF11262.6 T183204_2 - 0.12 11.4 5.3 0.19 10.8 5.3 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 IncA PF04156.12 T183204_2 - 0.13 11.9 8.5 0.22 11.2 8.5 1.3 1 0 0 1 1 1 0 IncA protein DUF972 PF06156.11 T183204_2 - 0.15 12.6 5.4 0.34 11.4 5.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) TMF_DNA_bd PF12329.6 T183204_2 - 0.2 11.5 15.9 0.35 10.8 15.9 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding GrpE PF01025.17 T183204_2 - 0.29 10.7 7.5 0.44 10.1 7.5 1.2 1 0 0 1 1 1 0 GrpE DUF1664 PF07889.10 T183204_2 - 0.29 11.0 4.0 0.67 9.8 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4530 PF15039.4 T183204_2 - 0.31 11.1 1.7 0.61 10.1 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) Prefoldin PF02996.15 T183204_2 - 0.41 10.4 5.7 0.9 9.3 5.7 1.5 1 0 0 1 1 1 0 Prefoldin subunit HAUS-augmin3 PF14932.4 T183204_2 - 0.44 9.9 10.9 0.68 9.3 10.9 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DivIC PF04977.13 T183204_2 - 0.54 9.9 12.5 0.85 9.3 2.8 2.3 1 1 1 2 2 2 0 Septum formation initiator DUF3450 PF11932.6 T183204_2 - 0.92 8.6 9.3 1.3 8.1 9.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) zf-RAG1 PF10426.7 T183204_2 - 1.6 8.8 6.9 0.71 9.9 0.1 3.2 3 0 0 3 3 2 0 Recombination-activating protein 1 zinc-finger domain DUF724 PF05266.12 T183204_2 - 2.7 7.6 10.7 4.3 7.0 10.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) CENP-H PF05837.10 T183204_2 - 5 7.4 9.1 2.4 8.5 6.2 1.9 1 1 0 1 1 1 0 Centromere protein H (CENP-H) bZIP_1 PF00170.19 T183204_2 - 8.1 6.5 12.1 3 7.9 3.6 2.5 1 1 1 2 2 2 0 bZIP transcription factor TSC22 PF01166.16 T183204_2 - 8.9 6.6 11.4 3.1 8.0 3.0 2.4 1 1 1 2 2 2 0 TSC-22/dip/bun family Ion_trans PF00520.29 T202279_1 - 9.5e-22 77.3 0.7 9.5e-22 77.3 0.7 2.0 2 0 0 2 2 2 1 Ion transport protein Ion_trans PF00520.29 T202279_2 - 2.2e-219 724.5 96.2 1.1e-64 217.9 22.9 4.3 4 0 0 4 4 4 4 Ion transport protein Na_trans_cytopl PF11933.6 T202279_2 - 4.4e-79 265.1 13.4 8.3e-79 264.2 13.4 1.4 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.11 T202279_2 - 1.6e-60 204.5 3.7 1.6e-60 204.5 3.7 2.8 3 0 0 3 3 3 1 Sodium ion transport-associated PKD_channel PF08016.10 T202279_2 - 3.8e-08 32.3 69.1 0.00018 20.2 0.1 8.5 5 3 3 8 8 8 6 Polycystin cation channel GPHH PF16905.3 T202279_2 - 1.2e-05 24.9 0.0 2.7e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated ATP-synt_B PF00430.16 T202279_2 - 0.0008 19.4 4.7 0.0008 19.4 4.7 2.2 2 0 0 2 2 2 1 ATP synthase B/B' CF(0) IQ PF00612.25 T202279_2 - 0.0042 16.6 1.0 0.012 15.2 1.0 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif SieB PF14163.4 T202279_2 - 0.24 10.8 4.1 0.74 9.2 0.7 3.3 2 0 0 2 2 2 0 Super-infection exclusion protein B DUF3704 PF12488.6 T074276_1 - 0.0059 16.1 1.3 0.031 13.8 1.3 2.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3704) Nop25 PF09805.7 T074276_2 - 0.35 11.2 9.3 0.6 10.4 9.3 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) 7tm_3 PF00003.20 T074276_3 - 4.1e-23 82.3 36.3 9.9e-23 81.0 36.3 1.7 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR PH PF00169.27 T142890_2 - 1e-26 93.3 0.1 8.8e-15 55.0 0.2 2.5 2 0 0 2 2 2 2 PH domain PH_11 PF15413.4 T142890_2 - 0.01 16.1 11.3 0.026 14.8 2.4 3.4 3 2 0 3 3 3 2 Pleckstrin homology domain Baculo_PEP_C PF04513.10 T142890_2 - 9.2 6.2 8.5 2.7 7.9 4.7 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMEM232 PF15877.3 T287225_2 - 2.2e-37 129.0 0.1 2.2e-37 129.0 0.1 1.6 2 0 0 2 2 2 1 Transmembrane protein family 232 TMEM232 PF15877.3 T287225_3 - 7.4e-163 542.7 9.5 9.8e-163 542.3 9.5 1.1 1 0 0 1 1 1 1 Transmembrane protein family 232 Beach PF02138.16 T033495_2 - 4.6e-111 370.5 1.4 7.3e-111 369.9 1.4 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.4 T033495_2 - 1.3e-22 79.7 0.0 2.6e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.30 T033495_2 - 4.8e-09 36.6 11.3 0.011 16.5 0.0 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat DUF4800 PF16057.3 T033495_2 - 0.012 14.8 2.8 0.026 13.7 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) ANAPC4_WD40 PF12894.5 T033495_2 - 0.091 12.9 0.2 16 5.8 0.0 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain ATG16 PF08614.9 T090440_3 - 0.0003 20.9 25.2 0.0003 20.9 25.2 10.4 1 1 8 9 9 9 2 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.7 T090440_3 - 0.0027 17.6 12.4 0.0027 17.6 12.4 10.9 2 1 6 10 10 10 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.6 T090440_3 - 0.0046 17.0 20.3 0.0046 17.0 20.3 12.7 2 1 8 14 14 14 1 TATA element modulatory factor 1 TATA binding HIP1_clath_bdg PF16515.3 T090440_3 - 0.0069 16.9 15.1 0.0069 16.9 15.1 13.7 5 3 7 13 13 13 3 Clathrin-binding domain of Huntingtin-interacting protein 1 Reo_sigmaC PF04582.10 T090440_3 - 0.5 9.6 84.9 0.073 12.3 4.9 8.8 3 2 5 9 9 9 0 Reovirus sigma C capsid protein HMG_box PF00505.17 T075250_1 - 5.2e-22 77.9 3.8 1.4e-21 76.6 3.8 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T075250_1 - 3.1e-08 34.0 1.1 3.1e-08 34.0 1.1 2.4 3 0 0 3 3 3 1 HMG-box domain MPS2 PF17060.3 T075250_1 - 0.23 10.5 6.4 0.38 9.8 6.4 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF4522 PF15022.4 T267704_1 - 7.2e-09 35.8 0.1 1.1e-08 35.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4522) DUF4522 PF15022.4 T267704_3 - 3.2e-42 143.4 0.1 4.7e-42 142.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4522) Phosphorylase PF00343.18 T060850_1 - 0 1155.3 0.0 0 1155.0 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase RasGEF PF00617.17 T060850_1 - 3e-39 134.8 0.0 5.6e-39 133.9 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 T060850_1 - 4e-10 39.3 7.9 4e-10 39.3 7.9 2.0 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.30 T060850_1 - 2.2e-09 36.1 0.8 0.00012 21.2 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T060850_1 - 1.5e-08 33.8 0.2 0.00048 19.7 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 T060850_1 - 4.3e-08 32.2 0.7 6.5e-05 22.1 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 T060850_1 - 8.6e-08 32.4 3.3 2.1e-06 28.0 0.6 2.2 1 1 1 2 2 2 2 EF-hand domain pair RasGEF_N PF00618.18 T060850_1 - 1.8e-07 31.2 0.1 2.5e-06 27.5 0.0 2.8 3 0 0 3 3 3 1 RasGEF N-terminal motif EF-hand_8 PF13833.4 T060850_1 - 0.004 16.8 1.8 0.027 14.1 0.3 2.3 2 0 0 2 2 2 1 EF-hand domain pair COX_ARM PF06481.12 T060850_1 - 0.15 11.8 0.1 0.32 10.8 0.1 1.6 1 0 0 1 1 1 0 COX Aromatic Rich Motif SF1-HH PF16275.3 T060850_3 - 2.6e-43 146.8 1.7 5.1e-43 145.9 1.7 1.5 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.27 T060850_3 - 1.3e-06 28.0 0.3 2.4e-06 27.1 0.3 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.21 T060850_3 - 0.00038 20.3 1.6 0.0019 18.0 1.6 2.3 1 0 0 1 1 1 1 Zinc knuckle HbrB PF08539.9 T235058_3 - 5.1e-13 49.2 0.3 4.4e-12 46.2 0.1 1.9 1 1 1 2 2 2 2 HbrB-like Neur_chan_memb PF02932.14 T120352_2 - 1.3e-178 591.5 8.6 1.5e-92 309.8 1.9 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 T120352_2 - 1.5e-143 475.5 12.2 7.8e-74 247.6 2.0 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.7 T120352_2 - 1.8 7.8 22.8 0.14 11.4 3.6 2.7 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Telomerase_RBD PF12009.6 T277581_1 - 3.4e-17 62.7 0.0 5.4e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain Telomerase_RBD PF12009.6 T277581_2 - 4.7e-18 65.4 0.2 1e-17 64.3 0.2 1.5 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.25 T277581_2 - 3.2e-12 46.3 0.0 1.2e-07 31.3 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RBFA PF02033.16 T165005_3 - 1.3e-12 48.0 0.2 3.2e-12 46.7 0.0 1.8 2 0 0 2 2 2 1 Ribosome-binding factor A Methyltransf_25 PF13649.4 T303850_2 - 1.1e-11 45.1 0.0 1.9e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T303850_2 - 1.4e-09 37.8 0.0 2.2e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 T303850_2 - 2e-08 34.7 0.0 3e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 T303850_2 - 2.6e-08 33.8 0.0 4e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 T303850_2 - 4.3e-08 33.6 0.0 7.2e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.12 T303850_2 - 0.0029 16.9 0.0 0.0093 15.3 0.0 1.7 2 0 0 2 2 2 1 Tellurite resistance protein TehB Ubie_methyltran PF01209.16 T303850_2 - 0.013 14.7 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.12 T303850_2 - 0.029 13.8 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain DUF3915 PF13054.4 T303850_3 - 1.4 8.8 5.6 2.2 8.1 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Lig_chan PF00060.24 T369932_2 - 4.9e-39 133.4 0.1 6.7e-39 133.0 0.1 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel CaM_bdg_C0 PF10562.7 T369932_2 - 9.9e-14 51.0 3.9 1.7e-13 50.2 3.9 1.4 1 0 0 1 1 1 1 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit SBP_bac_3 PF00497.18 T369932_2 - 3.5e-06 26.5 0.0 5.3e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Ion_trans_2 PF07885.14 T369932_2 - 0.033 14.0 0.5 0.081 12.8 0.5 1.6 1 0 0 1 1 1 0 Ion channel Sec1 PF00995.21 T016699_1 - 4.8e-119 399.0 5.1 5.8e-119 398.7 5.1 1.1 1 0 0 1 1 1 1 Sec1 family SGT1 PF07093.9 T016699_1 - 0.05 11.9 0.2 0.074 11.4 0.2 1.1 1 0 0 1 1 1 0 SGT1 protein fn3 PF00041.19 T016699_2 - 8.8e-17 61.1 0.9 0.00033 20.8 0.0 6.6 6 0 0 6 6 6 4 Fibronectin type III domain DUF2369 PF10179.7 T016699_2 - 0.001 19.3 10.5 0.0035 17.7 0.3 3.9 5 0 0 5 5 5 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 T016699_2 - 0.033 14.4 0.6 8.7 6.6 0.0 3.1 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III G_glu_transpept PF01019.19 T229951_1 - 3.7e-34 118.3 0.0 3.6e-21 75.4 0.0 2.1 2 0 0 2 2 2 2 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.19 T229951_3 - 6.4e-19 68.0 0.0 9.7e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase NPIP PF06409.9 T129823_1 - 5.8e-37 127.2 11.4 8e-18 64.5 7.5 2.2 1 1 1 2 2 2 2 Nuclear pore complex interacting protein (NPIP) DUF4615 PF15393.4 T354552_3 - 1.4e-36 125.5 0.2 2.7e-36 124.7 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4615) WD40 PF00400.30 T083639_2 - 5.9e-40 134.4 10.5 3.4e-08 33.9 0.2 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T083639_2 - 1e-15 57.6 0.0 0.012 15.8 0.0 5.0 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T083639_2 - 3.5e-06 26.1 0.3 0.13 11.1 0.0 3.7 1 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.9 T083639_2 - 1.5e-05 24.8 0.2 0.00024 20.9 0.1 2.4 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 T083639_2 - 0.0007 18.2 2.1 3.1 6.2 0.1 3.9 2 2 0 4 4 4 2 Nucleoporin Nup120/160 PRY PF13765.4 T142250_1 - 3.1e-16 58.6 0.2 6.6e-16 57.5 0.2 1.6 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 T142250_1 - 2.9e-12 46.6 0.2 5.4e-12 45.8 0.2 1.4 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 T142250_1 - 2.6e-06 27.3 14.1 2.6e-06 27.3 14.1 3.1 2 0 0 2 2 2 1 B-box zinc finger KRAB PF01352.25 T142250_1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 KRAB box WD40 PF00400.30 T142250_2 - 1.4e-17 63.6 11.4 5.4e-05 23.7 0.6 7.3 6 0 0 6 6 6 5 WD domain, G-beta repeat Transposase_1 PF01359.16 T142250_2 - 7.7e-13 48.0 0.0 4.4e-12 45.6 0.0 2.1 2 0 0 2 2 2 1 Transposase (partial DDE domain) KRAB PF01352.25 T142250_3 - 4.7e-13 48.5 1.3 4.7e-13 48.5 1.3 1.8 2 0 0 2 2 2 1 KRAB box CSD PF00313.20 T308853_1 - 2e-15 56.3 0.0 3.3e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCHC PF00098.21 T308853_1 - 1e-06 28.4 13.8 0.00081 19.2 2.7 2.9 2 0 0 2 2 2 2 Zinc knuckle Cadherin PF00028.15 T160464_1 - 3.6e-64 213.1 0.3 5e-17 62.0 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_pro PF08758.9 T160464_1 - 4e-23 81.3 0.1 1.1e-20 73.5 0.0 2.6 2 0 0 2 2 2 2 Cadherin prodomain like Cadherin_3 PF16184.3 T160464_1 - 0.0025 17.7 0.8 2.2 8.2 0.1 3.3 3 0 0 3 3 3 1 Cadherin-like Cadherin_C PF01049.15 T160464_2 - 1.5e-05 25.1 0.0 2.3e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Cadherin cytoplasmic region Solute_trans_a PF03619.14 T317295_1 - 6.4e-92 307.7 13.0 8e-92 307.4 13.0 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha EF-hand_7 PF13499.4 T091190_1 - 2.9e-11 43.5 10.9 0.0002 21.6 0.4 4.1 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.4 T091190_1 - 4.1e-08 32.7 8.7 9.6e-06 25.2 0.1 4.6 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_1 PF00036.30 T091190_1 - 7.9e-07 28.1 15.9 0.0003 20.0 0.3 5.4 6 0 0 6 6 6 2 EF hand EF-hand_6 PF13405.4 T091190_1 - 5.2e-06 25.9 10.6 0.0041 16.8 0.2 4.5 5 0 0 5 5 5 2 EF-hand domain EF-hand_4 PF12763.5 T091190_1 - 0.13 12.1 0.1 0.39 10.6 0.1 1.8 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.4 T091190_1 - 0.22 11.0 3.9 4.6 6.8 0.1 3.7 3 0 0 3 3 3 0 EF hand Homeobox PF00046.27 T079618_1 - 9.3e-59 195.0 36.1 4.1e-20 71.2 8.1 3.8 3 0 0 3 3 3 3 Homeobox domain Homeobox_KN PF05920.9 T079618_1 - 0.049 13.4 11.6 0.89 9.4 0.1 3.6 3 0 0 3 3 3 0 Homeobox KN domain Homeobox PF00046.27 T079618_2 - 1.5e-19 69.4 9.6 2.9e-19 68.5 9.6 1.5 1 0 0 1 1 1 1 Homeobox domain Hox9_act PF04617.11 T079618_3 - 1.8e-58 198.2 0.4 3.7e-58 197.2 0.4 1.5 1 0 0 1 1 1 1 Hox9 activation region Homeobox PF00046.27 T079618_3 - 6.2e-19 67.4 6.1 1.5e-18 66.2 6.1 1.7 1 0 0 1 1 1 1 Homeobox domain HA2 PF04408.21 T241988_2 - 5.7e-14 52.2 0.0 1.8e-13 50.6 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 T241988_2 - 1.2e-13 51.3 0.0 2.6e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain dsrm PF00035.24 T241988_2 - 4.4e-08 33.6 3.0 0.0053 17.3 0.1 2.5 2 0 0 2 2 2 2 Double-stranded RNA binding motif OB_NTP_bind PF07717.14 T241988_2 - 6.4e-07 29.3 0.0 1.5e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.27 T241988_2 - 1.7e-06 27.8 0.0 3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Dicer_dimer PF03368.12 T241988_2 - 0.00089 19.3 0.6 0.14 12.2 0.2 3.0 3 0 0 3 3 3 1 Dicer dimerisation domain AAA_22 PF13401.4 T241988_2 - 0.014 15.5 0.0 0.044 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.18 T241988_2 - 0.047 12.6 0.0 0.085 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.4 T241988_2 - 0.048 13.9 0.0 0.17 12.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.4 T241988_2 - 0.062 13.6 0.2 0.2 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.4 T241988_2 - 0.083 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Bombolitin PF08096.9 T241988_2 - 0.12 12.5 1.2 1.4 9.2 0.2 3.0 3 0 0 3 3 3 0 Bombolitin family Beach PF02138.16 T267576_3 - 1.4e-127 424.7 0.1 2.2e-127 424.0 0.1 1.3 1 0 0 1 1 1 1 Beige/BEACH domain FYVE PF01363.19 T267576_3 - 1.7e-17 63.1 12.3 1.7e-17 63.1 12.3 2.7 2 0 0 2 2 2 1 FYVE zinc finger PH_BEACH PF14844.4 T267576_3 - 6.1e-12 45.4 0.0 1.6e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4704 PF15787.3 T267576_3 - 4.2e-07 29.3 5.4 9.4e-07 28.2 1.8 3.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4704) WD40 PF00400.30 T267576_3 - 4.4e-05 24.0 12.3 0.037 14.8 0.3 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat Laminin_G_3 PF13385.4 T267576_3 - 0.0011 19.1 0.0 0.0031 17.5 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF4800 PF16057.3 T267576_3 - 0.0017 17.6 0.8 0.0034 16.6 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) E3_UbLigase_R4 PF13764.4 T267576_3 - 0.037 12.1 0.2 0.082 10.9 0.2 1.5 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 Filament PF00038.19 T078961_2 - 9.6e-117 389.9 37.9 1.2e-116 389.6 37.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 T078961_2 - 6e-45 153.2 43.8 6e-45 153.2 43.8 2.7 2 1 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 T078961_2 - 1.1e-05 25.4 29.8 0.0014 18.5 0.3 3.8 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.4 T078961_2 - 0.00013 20.7 18.3 0.0002 20.1 17.8 1.5 1 1 0 1 1 1 1 AAA domain CENP-F_leu_zip PF10473.7 T078961_2 - 0.0007 19.5 26.7 0.011 15.7 8.6 3.1 1 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Alanine_zipper PF11839.6 T078961_2 - 0.0011 19.1 6.0 0.0035 17.5 6.0 1.8 1 0 0 1 1 1 1 Alanine-zipper, major outer membrane lipoprotein Spc7 PF08317.9 T078961_2 - 0.0013 17.6 34.0 0.025 13.3 7.9 3.0 1 1 2 3 3 3 3 Spc7 kinetochore protein ATG16 PF08614.9 T078961_2 - 0.009 16.1 26.6 0.4 10.7 14.5 2.5 1 1 0 2 2 2 2 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.10 T078961_2 - 0.035 13.4 5.2 0.63 9.3 0.3 2.4 1 1 0 2 2 2 0 Reovirus sigma C capsid protein Taxilin PF09728.7 T078961_2 - 0.076 12.1 29.2 0.77 8.8 29.3 2.6 1 1 0 1 1 1 0 Myosin-like coiled-coil protein Golgin_A5 PF09787.7 T078961_2 - 0.084 12.2 28.3 0.023 14.0 10.5 2.8 1 1 3 4 4 4 0 Golgin subfamily A member 5 DUF745 PF05335.11 T078961_2 - 0.14 11.8 16.4 0.13 11.9 10.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DUF5082 PF16888.3 T078961_2 - 0.28 11.4 23.4 0.44 10.8 0.9 3.9 1 1 2 4 4 4 0 Domain of unknown function (DUF5082) ADIP PF11559.6 T078961_2 - 0.48 10.4 27.1 0.31 11.0 11.0 3.3 2 2 0 2 2 2 0 Afadin- and alpha -actinin-Binding Ax_dynein_light PF10211.7 T078961_2 - 0.58 9.9 28.2 2.3 8.0 10.6 3.0 1 1 2 3 3 3 0 Axonemal dynein light chain DUF948 PF06103.9 T078961_2 - 0.59 10.3 8.9 3.2 7.9 1.6 3.9 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.10 T078961_2 - 0.71 9.8 20.2 0.062 13.2 1.5 3.9 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tropomyosin_1 PF12718.5 T078961_2 - 0.91 9.5 29.3 0.036 14.1 12.6 3.3 2 1 1 3 3 3 0 Tropomyosin like DUF3502 PF12010.6 T078961_2 - 0.95 10.0 4.1 5.6 7.5 4.1 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3502) IncA PF04156.12 T078961_2 - 0.97 9.1 28.8 1.1 8.8 14.7 3.1 1 1 1 2 2 2 0 IncA protein DUF883 PF05957.11 T078961_2 - 1.4 9.4 16.1 2.7 8.5 5.8 3.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF3584 PF12128.6 T078961_2 - 1.6 6.0 30.5 0.47 7.8 14.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) ATPase PF06745.11 T078961_2 - 1.7 7.8 5.1 14 4.8 0.8 2.4 2 1 0 2 2 2 0 KaiC BLOC1_2 PF10046.7 T078961_2 - 2.2 8.5 16.5 2.5 8.3 0.5 3.8 2 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lebercilin PF15619.4 T078961_2 - 2.3 7.7 32.0 0.39 10.2 15.0 2.5 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Jnk-SapK_ap_N PF09744.7 T078961_2 - 2.6 8.1 29.3 0.12 12.5 2.3 3.4 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 COG5 PF10392.7 T078961_2 - 2.7 8.1 9.8 0.11 12.6 2.5 2.3 2 1 1 3 3 3 0 Golgi transport complex subunit 5 WXG100 PF06013.10 T078961_2 - 3.7 7.7 7.5 63 3.8 5.4 3.6 2 1 0 2 2 2 0 Proteins of 100 residues with WXG ISG65-75 PF11727.6 T078961_2 - 4.6 6.3 11.3 0.7 8.9 5.5 2.1 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF1451 PF07295.9 T078961_2 - 4.7 7.1 14.8 6.4 6.7 3.8 2.6 2 1 0 2 2 2 0 Zinc-ribbon containing domain DUF342 PF03961.11 T078961_2 - 5 5.5 21.0 4.8 5.5 9.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF342) APG6 PF04111.10 T078961_2 - 5.7 6.1 33.8 0.12 11.6 10.3 3.0 1 1 2 3 3 3 0 Autophagy protein Apg6 CHDCT2 PF08074.9 T078961_2 - 7.2 6.6 15.2 12 5.9 4.9 2.6 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain Cob_adeno_trans PF01923.16 T078961_2 - 7.4 6.6 8.7 16 5.4 6.8 2.3 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Tup_N PF08581.8 T078961_2 - 8.2 6.7 26.0 3.5 7.9 0.4 5.3 2 2 3 6 6 6 0 Tup N-terminal DUF1664 PF07889.10 T078961_2 - 8.3 6.3 17.0 1.5 8.7 1.4 4.0 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) DASH_Duo1 PF08651.8 T078961_2 - 8.9 6.0 10.6 3.2 7.4 0.9 3.8 4 1 0 4 4 4 0 DASH complex subunit Duo1 POLO_box PF00659.16 T009924_1 - 4.9e-13 48.9 0.0 1.6e-12 47.3 0.0 1.8 2 0 0 2 2 2 1 POLO box duplicated region Pkinase PF00069.23 T009924_3 - 6.2e-64 215.8 0.0 1.7e-57 194.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 T009924_3 - 2.5e-30 105.5 0.0 2.1e-29 102.5 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase POLO_box PF00659.16 T009924_3 - 2.3e-08 34.0 0.1 3.7e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 POLO box duplicated region Kinase-like PF14531.4 T009924_3 - 2e-05 23.9 0.0 0.067 12.4 0.0 2.2 1 1 1 2 2 2 2 Kinase-like Ribosomal_S21e PF01249.16 T221732_3 - 1.7e-41 140.0 0.1 2.4e-41 139.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S21e ETRAMP PF09716.8 T181825_1 - 5.8 6.9 6.6 0.27 11.2 0.1 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) CTNNB1_binding PF08347.9 T181825_3 - 0.16 12.0 1.8 0.26 11.3 1.8 1.2 1 0 0 1 1 1 0 N-terminal CTNNB1 binding SR-25 PF10500.7 T181825_3 - 0.2 11.1 11.9 0.32 10.5 11.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.9 T181825_3 - 1.6 8.8 10.1 2.5 8.2 10.1 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Med19 PF10278.7 T181825_3 - 2.4 7.9 16.4 3.8 7.3 16.4 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Peptidase_S49_N PF08496.8 T181825_3 - 8.5 6.3 8.8 19 5.2 8.8 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Tmemb_14 PF03647.11 T297299_3 - 6.2e-21 74.8 11.7 1.4e-20 73.7 11.7 1.6 1 0 0 1 1 1 1 Transmembrane proteins 14C PIEZO PF15917.3 T221158_1 - 1.2 8.4 5.6 2.1 7.6 5.6 1.3 1 0 0 1 1 1 0 Piezo G-alpha PF00503.18 T221158_2 - 4.9e-43 147.5 0.0 6.6e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit G-alpha PF00503.18 T221158_3 - 7.2e-53 179.9 0.1 9.4e-53 179.5 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 T221158_3 - 3.6e-10 39.5 0.4 5.9e-10 38.8 0.4 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SET PF00856.26 T181264_3 - 0.0096 16.2 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 1 SET domain JMY PF15871.3 T120940_3 - 3.4e-138 460.7 24.5 4.4e-104 348.5 13.9 3.7 4 0 0 4 4 4 3 Junction-mediating and -regulatory protein WHAMM-JMY_N PF15920.3 T120940_3 - 5.2e-27 93.3 0.1 9.9e-27 92.4 0.1 1.5 1 0 0 1 1 1 1 N-terminal of Junction-mediating and WASP homolog-associated WH2 PF02205.18 T120940_3 - 0.011 15.4 0.1 0.044 13.5 0.1 2.0 2 0 0 2 2 2 0 WH2 motif DUF1640 PF07798.9 T065023_1 - 3.5e-57 193.1 15.4 5.5e-57 192.5 15.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) JAKMIP_CC3 PF16034.3 T065023_1 - 0.0041 17.0 9.7 0.0062 16.4 9.7 1.1 1 0 0 1 1 1 1 JAKMIP CC3 domain Spatacsin_C PF14649.4 T115792_3 - 2.4e-102 342.0 4.5 6.9e-102 340.5 4.5 1.8 1 0 0 1 1 1 1 Spatacsin C-terminus PAT1 PF09770.7 T115792_3 - 2e-12 46.1 0.2 7.9e-11 40.9 0.0 2.3 2 0 0 2 2 2 2 Topoisomerase II-associated protein PAT1 ANAPC8 PF04049.11 T289715_2 - 5.6e-26 91.1 9.3 3.6e-24 85.3 4.6 3.4 2 1 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.26 T289715_2 - 2.1e-23 81.0 31.9 1.3e-05 24.6 0.1 9.9 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_2 PF07719.15 T289715_2 - 2.3e-22 77.1 31.9 0.001 18.9 0.1 10.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_8 PF13181.4 T289715_2 - 8e-16 56.7 25.7 0.00019 21.3 0.0 10.1 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.4 T289715_2 - 4.8e-11 42.9 11.8 0.0026 18.1 0.1 6.5 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.4 T289715_2 - 5.3e-11 42.2 15.2 0.0093 16.6 0.0 8.3 7 2 3 10 10 10 3 Tetratricopeptide repeat TPR_11 PF13414.4 T289715_2 - 2e-10 40.1 11.5 3.7e-06 26.4 0.2 4.9 3 1 1 4 4 4 3 TPR repeat TPR_7 PF13176.4 T289715_2 - 4.4e-07 29.3 19.2 0.96 9.5 0.2 8.5 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_17 PF13431.4 T289715_2 - 9e-07 28.7 11.0 0.19 12.0 0.0 5.9 7 0 0 7 7 6 3 Tetratricopeptide repeat ANAPC3 PF12895.5 T289715_2 - 4.7e-06 26.6 32.8 0.0033 17.4 0.1 6.2 5 1 0 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.4 T289715_2 - 1.2e-05 25.7 13.9 0.0049 17.4 0.0 6.5 6 2 1 7 7 6 1 Tetratricopeptide repeat TPR_6 PF13174.4 T289715_2 - 0.00041 20.7 23.6 3.5 8.4 0.0 8.7 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_12 PF13424.4 T289715_2 - 0.0055 16.8 25.0 0.57 10.4 0.1 7.6 5 2 4 9 9 9 4 Tetratricopeptide repeat DUF772 PF05598.9 T289715_2 - 0.0071 16.2 0.1 0.017 15.0 0.1 1.6 1 0 0 1 1 1 1 Transposase domain (DUF772) TPR_9 PF13371.4 T289715_2 - 0.021 14.9 4.2 0.05 13.6 0.2 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 T289715_2 - 0.036 13.8 11.3 19 5.2 0.1 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_15 PF13429.4 T289715_2 - 0.22 10.6 7.7 0.28 10.2 1.7 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat SIT PF15330.4 T154061_1 - 1.5e-33 115.5 0.7 2.5e-33 114.8 0.7 1.4 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT V-set PF07686.15 T154061_1 - 1.6e-11 44.2 0.9 2.7e-11 43.5 0.9 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 T154061_1 - 0.57 10.3 2.4 2.2 8.4 2.4 1.9 1 1 0 1 1 1 0 Immunoglobulin domain zf-CCCH PF00642.22 T080144_1 - 4.1e-05 23.2 0.6 4.1e-05 23.2 0.6 3.6 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 T080144_1 - 0.0033 17.7 9.0 0.081 13.3 2.2 3.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger TSC22 PF01166.16 T080144_1 - 0.082 13.1 1.8 0.16 12.2 1.8 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family Pkinase_Tyr PF07714.15 T080144_2 - 9.3e-77 257.7 0.0 1.3e-76 257.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 T080144_2 - 3.4e-60 200.9 0.3 6.2e-29 100.2 0.0 2.4 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 T080144_2 - 7.5e-52 174.5 77.5 2e-47 160.1 29.0 3.5 2 1 1 3 3 3 2 Growth factor receptor domain IV Furin-like PF00757.18 T080144_2 - 2.8e-33 114.8 84.3 4.2e-30 104.5 36.6 4.3 2 1 1 3 3 3 2 Furin-like cysteine rich region Pkinase PF00069.23 T080144_2 - 8.6e-32 110.4 0.0 1.3e-31 109.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Peptidase_M24 PF00557.22 T080144_2 - 4.8e-23 81.8 0.3 8.1e-23 81.1 0.3 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Ribosomal_L41 PF05162.11 T080144_2 - 1.3e-08 34.6 32.8 4.6e-08 32.8 32.8 2.0 1 0 0 1 1 1 1 Ribosomal protein L41 EF-hand_6 PF13405.4 T080144_2 - 1.3e-07 30.9 0.5 0.008 15.9 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.30 T080144_2 - 1e-05 24.6 1.0 0.089 12.3 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 T080144_2 - 3.5e-05 24.1 0.1 0.014 15.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair C2 PF00168.28 T080144_3 - 3.7e-92 303.3 0.0 3.5e-23 81.7 0.0 5.5 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.3 T080144_3 - 4.1e-77 257.6 0.1 6.2e-77 257.0 0.1 1.3 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain EF-hand_6 PF13405.4 T080144_3 - 3.9e-07 29.3 0.1 0.00035 20.1 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 T080144_3 - 4.2e-07 28.9 2.3 0.0033 16.7 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 T080144_3 - 0.0014 19.0 0.0 0.86 10.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair V-set PF07686.15 T068241_2 - 6.1e-36 122.8 0.0 6.5e-20 71.2 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 T068241_2 - 2e-09 37.4 0.0 0.0027 17.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 T068241_2 - 8.3e-09 35.8 0.0 0.0029 18.0 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 T068241_2 - 5.3e-07 29.5 0.0 0.014 15.3 0.0 2.6 1 1 1 2 2 2 2 Immunoglobulin I-set domain Izumo-Ig PF16706.3 T068241_2 - 0.0052 16.7 0.0 0.92 9.5 0.0 2.4 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.4 T068241_2 - 0.007 16.6 0.0 7.5 6.8 0.0 3.2 2 2 0 2 2 2 2 Immunoglobulin domain PRIMA1 PF16101.3 T068241_2 - 0.083 12.8 0.5 0.15 12.0 0.5 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Rdx PF10262.7 T175290_2 - 1e-05 25.5 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Rdx family GBP_C PF02841.12 T014718_2 - 9.1e-127 422.4 28.3 1.2e-126 422.0 28.3 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain GBP PF02263.17 T014718_2 - 6.7e-119 395.8 0.0 6.7e-119 395.8 0.0 2.1 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.21 T014718_2 - 0.015 15.3 0.0 0.037 14.0 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Phlebovirus_NSM PF07246.9 T014718_2 - 3.3 6.9 14.5 5.8 6.1 14.5 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Helitron_like_N PF14214.4 T014718_2 - 3.6 7.6 8.1 2.9 7.9 6.1 1.9 2 0 0 2 2 2 0 Helitron helicase-like domain at N-terminus DUF1664 PF07889.10 T014718_2 - 5.2 7.0 9.5 12 5.8 9.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HMGL-like PF00682.17 T305519_1 - 5.7e-49 166.9 0.0 6.8e-49 166.7 0.0 1.1 1 0 0 1 1 1 1 HMGL-like DAGK_acc PF00609.17 T318954_1 - 5.5e-56 189.2 0.0 8.9e-56 188.5 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 T318954_1 - 2.1e-27 95.1 0.0 3.5e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 T318954_1 - 5.3e-18 64.5 43.1 1.9e-12 46.7 6.4 3.2 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.30 T318954_1 - 0.00021 20.5 0.0 0.0005 19.3 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.4 T318954_1 - 0.007 15.7 0.2 0.017 14.5 0.0 1.8 2 0 0 2 2 2 1 EF hand DAG_kinase_N PF14513.4 T318954_3 - 4.7e-48 163.4 2.0 9.8e-46 155.9 2.0 2.2 1 1 0 1 1 1 1 Diacylglycerol kinase N-terminus BSMAP PF12280.6 T170741_1 - 2.7e-67 226.4 0.5 3.7e-67 225.9 0.5 1.2 1 0 0 1 1 1 1 Brain specific membrane anchored protein PH_12 PF16457.3 T134504_1 - 6e-26 91.4 0.0 9.6e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain DUF3361 PF11841.6 T134504_3 - 4.9e-48 162.8 0.0 8.1e-48 162.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.11 T134504_3 - 5.6e-42 143.7 0.0 8.4e-42 143.1 0.0 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family E2F_CC-MB PF16421.3 T134504_3 - 1e-32 112.3 1.7 2.2e-32 111.2 0.1 2.4 3 0 0 3 3 3 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.18 T134504_3 - 3.2e-23 81.4 0.2 7e-23 80.3 0.2 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain DUF3584 PF12128.6 T134504_3 - 0.094 10.1 0.4 0.14 9.6 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SPX PF03105.17 T134504_3 - 0.61 9.9 3.2 1.2 8.9 3.2 1.4 1 0 0 1 1 1 0 SPX domain AbLIM_anchor PF16182.3 T340186_1 - 1e-81 275.5 14.7 1e-81 275.5 14.7 2.6 2 1 0 2 2 2 1 Putative adherens-junction anchoring region of AbLIM FGF PF00167.16 T340186_1 - 6.4e-39 132.8 0.1 2.2e-38 131.1 0.7 1.6 2 0 0 2 2 2 1 Fibroblast growth factor Nucleoplasmin PF03066.13 T340186_1 - 3.4e-31 107.6 0.0 6.8e-31 106.7 0.0 1.4 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain VHP PF02209.17 T340186_1 - 5.4e-14 51.8 0.8 1.2e-13 50.7 0.8 1.6 1 0 0 1 1 1 1 Villin headpiece domain YL1 PF05764.11 T340186_1 - 0.0021 18.1 6.1 0.0021 18.1 6.1 2.4 2 0 0 2 2 2 1 YL1 nuclear protein MPP6 PF10175.7 T340186_1 - 3.7 7.9 10.8 9.1 6.7 3.7 2.5 2 0 0 2 2 2 0 M-phase phosphoprotein 6 Ras PF00071.20 T022330_3 - 6.1e-56 188.3 0.2 7.7e-56 188.0 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T022330_3 - 1.2e-30 106.1 0.1 1.7e-30 105.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T022330_3 - 1.7e-11 43.8 0.1 2.4e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 T022330_3 - 1.2e-06 28.5 0.0 1.9e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 T022330_3 - 9.9e-05 22.2 0.2 0.038 13.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 T022330_3 - 0.0018 17.6 0.0 0.0023 17.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 T022330_3 - 0.0052 16.1 0.0 0.01 15.2 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.4 T022330_3 - 0.016 15.3 0.1 0.042 14.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.4 T022330_3 - 0.039 13.9 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 T022330_3 - 0.045 14.0 0.1 0.07 13.4 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.4 T022330_3 - 0.089 12.4 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.7 T022330_3 - 0.13 11.8 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.4 T022330_3 - 0.15 12.2 0.7 2.2 8.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.12 T022330_3 - 0.15 11.9 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.25 T022330_3 - 0.15 12.4 0.1 0.35 11.3 0.1 1.6 1 1 0 1 1 1 0 ABC transporter Myosin_head PF00063.19 T154541_1 - 1.3e-49 168.9 0.0 1.7e-49 168.5 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.15 T154541_1 - 1.6e-19 70.2 0.1 1.6e-19 70.2 0.1 2.5 3 0 0 3 3 3 1 MyTH4 domain SH3_2 PF07653.15 T154541_1 - 5.5e-10 38.7 0.0 1.2e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T154541_1 - 1.1e-07 31.4 0.0 1.7e-06 27.7 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 T154541_1 - 0.13 11.7 0.0 1.7 8.1 0.0 2.5 2 0 0 2 2 2 0 SH3 domain IQ PF00612.25 T154541_1 - 8.3 6.4 8.3 2.4 8.0 3.7 2.6 2 0 0 2 2 2 0 IQ calmodulin-binding motif MyTH4 PF00784.15 T154541_2 - 3.2e-26 91.8 0.1 9.2e-26 90.3 0.0 1.9 2 0 0 2 2 2 1 MyTH4 domain FERM_M PF00373.16 T154541_2 - 4.1e-15 56.1 0.2 6.7e-15 55.4 0.2 1.4 1 0 0 1 1 1 1 FERM central domain Myosin_head PF00063.19 T154541_2 - 2.8e-09 35.7 0.0 0.00046 18.4 0.0 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) Myosin_head PF00063.19 T154541_3 - 2.4e-09 35.9 0.0 3.4e-09 35.4 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) TTL PF03133.13 T237711_3 - 2.5e-84 282.8 0.0 3.7e-84 282.2 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.4 T237711_3 - 0.12 11.4 0.0 1.2 8.1 0.0 2.0 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Pkinase PF00069.23 T165895_1 - 1.4e-24 86.8 0.0 1.9e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T165895_1 - 4.9e-13 48.8 0.0 6.9e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CK1gamma_C PF12605.6 T165895_1 - 3.4e-09 37.6 5.1 4.2e-07 30.9 0.9 2.9 1 1 1 2 2 2 2 Casein kinase 1 gamma C terminal GDWWSH PF15667.3 T189500_3 - 6.2e-105 350.0 4.3 9.1e-105 349.4 4.3 1.2 1 0 0 1 1 1 1 Protein of unknown function with motif GDWWSH IL8 PF00048.18 T146054_1 - 4.9e-22 77.7 0.3 1e-21 76.7 0.3 1.6 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like AA_permease PF00324.19 T329916_1 - 2.9e-111 372.3 32.4 8e-90 301.6 8.7 2.1 2 0 0 2 2 2 2 Amino acid permease ARS2 PF04959.11 T329916_1 - 2e-90 302.3 0.7 4.4e-90 301.2 0.7 1.6 1 0 0 1 1 1 1 Arsenite-resistance protein 2 SLC12 PF03522.13 T329916_1 - 5.9e-18 64.9 10.1 3.8e-10 39.2 0.0 4.2 4 0 0 4 4 4 3 Solute carrier family 12 DUF3546 PF12066.6 T329916_1 - 2e-17 63.3 0.0 5.2e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) RRM_1 PF00076.20 T329916_1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.7 T329916_1 - 0.92 7.9 6.9 1.4 7.3 6.9 1.1 1 0 0 1 1 1 0 Transmembrane protein MIP-T3 PF10243.7 T329916_1 - 7.8 5.0 38.8 13 4.2 38.8 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF3546 PF12066.6 T329916_2 - 8.6e-12 45.2 1.6 1.3e-11 44.6 1.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) LIM PF00412.20 T329916_3 - 8.2e-29 99.5 21.6 3.9e-12 46.1 1.4 3.4 3 0 0 3 3 3 3 LIM domain CtIP_N PF10482.7 T221741_1 - 2.9e-14 53.0 3.4 5e-14 52.3 3.4 1.3 1 0 0 1 1 1 1 Tumour-suppressor protein CtIP N-terminal domain HALZ PF02183.16 T221741_1 - 0.087 12.9 0.2 0.17 12.0 0.2 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper HAP1_N PF04849.11 T221741_1 - 0.21 10.6 1.1 0.33 10.0 1.1 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DivIC PF04977.13 T221741_1 - 0.25 11.0 0.1 0.47 10.1 0.1 1.3 1 0 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.19 T221741_1 - 0.31 11.1 3.2 0.62 10.1 3.2 1.4 1 0 0 1 1 1 0 bZIP transcription factor CtIP_N PF10482.7 T221741_2 - 3.5e-26 91.5 2.3 3.5e-26 91.5 2.3 1.9 2 0 0 2 2 2 1 Tumour-suppressor protein CtIP N-terminal domain Cyclin_N PF00134.21 T221741_2 - 9.1e-07 28.6 0.2 1.4e-06 28.0 0.2 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF4472 PF14739.4 T221741_2 - 1.2 9.7 4.6 2.2 8.9 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) ATP1G1_PLM_MAT8 PF02038.14 T173497_1 - 1.6e-26 91.3 0.3 1.6e-26 91.3 0.3 2.2 2 0 0 2 2 2 1 ATP1G1/PLM/MAT8 family ATP1G1_PLM_MAT8 PF02038.14 T173497_2 - 8.8e-35 117.7 0.1 1e-19 69.5 0.0 2.4 2 0 0 2 2 2 2 ATP1G1/PLM/MAT8 family OATP PF03137.18 T064052_2 - 8.3e-163 542.4 6.2 1e-162 542.1 6.2 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 T064052_2 - 3.3e-19 68.9 19.5 1.7e-18 66.6 19.5 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Kazal_2 PF07648.13 T064052_2 - 0.13 12.4 2.8 0.38 10.8 2.8 1.8 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain OATP PF03137.18 T064052_3 - 9.7e-24 83.4 0.1 1.7e-23 82.6 0.1 1.4 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family zf-H2C2_2 PF13465.4 T182362_1 - 2.8e-105 340.3 106.5 8.2e-09 35.4 0.1 18.5 17 1 0 17 17 17 14 Zinc-finger double domain zf-C2H2 PF00096.24 T182362_1 - 1.6e-67 220.3 128.0 3.4e-07 30.2 0.9 16.9 17 0 0 17 17 17 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T182362_1 - 2e-36 121.3 129.0 0.0004 20.8 1.5 17.4 17 0 0 17 17 17 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T182362_1 - 1.9e-25 88.1 90.6 9.2e-05 22.2 2.5 15.7 15 0 0 15 15 15 10 C2H2-type zinc finger KRAB PF01352.25 T182362_1 - 3.2e-20 71.4 0.7 6.4e-20 70.4 0.7 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 T182362_1 - 6.6e-11 42.1 65.8 0.14 12.4 0.8 14.3 14 0 0 14 14 14 7 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T182362_1 - 2e-05 24.5 77.1 0.052 13.6 0.4 10.3 2 1 9 12 12 12 9 Zinc ribbon domain Csm1 PF12539.6 T182362_1 - 0.018 15.5 3.0 31 5.2 0.1 4.1 4 1 1 5 5 5 0 Chromosome segregation protein Csm1/Pcs1 CpXC PF14353.4 T182362_1 - 0.023 14.6 49.1 4.3 7.2 0.1 12.2 6 4 6 12 12 12 0 CpXC protein zf-H2C2_2 PF13465.4 T182362_3 - 3.5e-12 46.0 12.2 6.5e-07 29.4 1.8 4.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.24 T182362_3 - 4.9e-06 26.6 7.0 0.0012 19.0 0.4 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T182362_3 - 0.00012 22.5 6.4 0.012 16.3 0.3 3.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T182362_3 - 0.0071 16.5 2.8 0.14 12.4 0.1 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.9 T182362_3 - 1.5 8.7 6.8 0.15 11.8 0.2 2.9 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger CLAMP PF14769.4 T130452_1 - 1.4e-13 51.0 0.2 2.3e-13 50.3 0.2 1.3 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 CLAMP PF14769.4 T130452_3 - 2.9e-12 46.7 0.0 4.9e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 C2 PF00168.28 T349051_2 - 1.5e-36 124.7 0.0 6e-19 68.1 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 T349051_2 - 7.7e-15 55.0 13.2 1.6e-14 54.0 13.2 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger PDZ PF00595.22 T349051_2 - 1.5e-05 25.2 0.0 3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Filamin PF00630.17 T018161_2 - 5.8e-20 71.9 0.2 9.8e-20 71.2 0.2 1.4 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-B_box PF00643.22 T018161_2 - 2.8e-09 36.9 34.9 6.8e-09 35.6 4.7 3.7 3 0 0 3 3 3 2 B-box zinc finger zf-RING_UBOX PF13445.4 T018161_2 - 7e-07 29.0 1.5 7e-07 29.0 1.5 3.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 T018161_2 - 0.00038 20.1 2.8 0.00038 20.1 2.8 3.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T018161_2 - 0.0017 18.1 1.7 0.0017 18.1 1.7 4.8 5 0 0 5 5 5 1 zinc-RING finger domain ATP-synt_ab_C PF00306.25 T018161_2 - 0.015 15.5 0.7 0.025 14.8 0.7 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta chain, C terminal domain DegS PF05384.9 T018161_2 - 0.14 11.5 2.0 0.23 10.8 2.0 1.2 1 0 0 1 1 1 0 Sensor protein DegS DUF4455 PF14643.4 T018161_2 - 0.16 10.6 2.1 0.23 10.0 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) BAR PF03114.16 T018161_2 - 0.16 11.4 0.3 0.25 10.8 0.3 1.1 1 0 0 1 1 1 0 BAR domain Apolipoprotein PF01442.16 T018161_2 - 0.43 10.3 3.6 0.67 9.7 3.6 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Myotub-related PF06602.12 T375583_3 - 6.7e-143 475.6 0.0 8.7e-143 475.2 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Ank_2 PF12796.5 T375583_3 - 5e-36 123.0 3.3 6.5e-13 48.9 0.3 3.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T375583_3 - 1.2e-17 62.0 5.7 0.022 15.2 0.0 6.1 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.4 T375583_3 - 5.8e-17 61.4 4.1 1.1e-05 25.6 0.1 4.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.4 T375583_3 - 8.2e-17 61.2 2.9 9.8e-09 35.5 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.28 T375583_3 - 5.7e-14 51.7 12.0 0.00028 21.0 0.3 5.7 5 0 0 5 5 5 3 Ankyrin repeat SOCS_box PF07525.14 T375583_3 - 2e-08 34.3 1.8 7.2e-08 32.5 1.8 2.0 1 0 0 1 1 1 1 SOCS box Vps36_ESCRT-II PF11605.6 T375583_3 - 0.0039 17.2 0.0 0.0077 16.3 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Y_phosphatase PF00102.25 T375583_3 - 0.0055 16.2 0.0 0.0097 15.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 T375583_3 - 0.021 14.5 0.1 0.049 13.3 0.1 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain GRAM PF02893.18 T375583_3 - 0.077 12.7 0.0 0.24 11.1 0.0 1.8 2 0 0 2 2 2 0 GRAM domain SPICE PF15678.3 T248301_1 - 9.5e-159 529.0 22.6 9.5e-159 529.0 22.6 3.5 3 0 0 3 3 3 1 Centriole duplication and mitotic chromosome congression WD40 PF00400.30 T248301_3 - 7.1e-10 39.2 0.0 0.012 16.3 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T248301_3 - 0.0083 16.3 0.0 1.2 9.4 0.0 3.5 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain zf-CCCH_2 PF14608.4 T108708_3 - 6.3e-17 61.2 58.3 5.1e-05 23.5 6.2 5.5 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger PWI PF01480.15 T108708_3 - 0.027 14.6 0.0 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 PWI domain zf-TAZ PF02135.14 T108708_3 - 1.3 9.4 18.8 0.23 11.8 2.3 2.5 2 0 0 2 2 2 0 TAZ zinc finger Adhes-Ig_like PF09085.8 T165208_2 - 5.1e-51 171.3 0.2 8.2e-51 170.7 0.2 1.3 1 0 0 1 1 1 1 Adhesion molecule, immunoglobulin-like DUF4181 PF13789.4 T148675_1 - 0.016 15.3 1.5 0.036 14.2 1.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) EGF_CA PF07645.13 T175569_1 - 1.5e-27 95.3 58.4 2e-08 34.1 3.1 5.5 5 0 0 5 5 5 5 Calcium-binding EGF domain cEGF PF12662.5 T175569_1 - 1.1e-12 47.4 34.9 0.00022 21.0 0.2 6.0 6 0 0 6 6 6 5 Complement Clr-like EGF-like TB PF00683.15 T175569_1 - 8e-12 44.5 4.4 2.7e-11 42.8 4.4 2.0 1 0 0 1 1 1 1 TB domain EGF PF00008.25 T175569_1 - 1.5e-11 44.3 51.8 0.002 18.2 4.9 6.0 5 0 0 5 5 5 4 EGF-like domain EGF_3 PF12947.5 T175569_1 - 6.9e-07 29.2 40.2 0.0084 16.2 1.1 5.7 5 0 0 5 5 5 5 EGF domain hEGF PF12661.5 T175569_1 - 0.0042 17.6 2.7 0.0042 17.6 2.7 6.9 6 0 0 6 6 6 4 Human growth factor-like EGF EGF_CA PF07645.13 T175569_2 - 9.5e-110 358.5 185.2 5.4e-11 42.4 3.9 15.9 16 0 0 16 16 16 14 Calcium-binding EGF domain cEGF PF12662.5 T175569_2 - 2.7e-71 234.9 111.5 1.4e-08 34.4 1.9 15.8 16 0 0 16 16 16 14 Complement Clr-like EGF-like hEGF PF12661.5 T175569_2 - 3.7e-18 65.3 217.5 0.0093 16.5 6.5 20.0 21 2 0 21 21 21 12 Human growth factor-like EGF EGF_3 PF12947.5 T175569_2 - 2.1e-17 62.9 155.8 4.4e-05 23.4 4.5 16.4 13 1 1 15 15 15 10 EGF domain EGF PF00008.25 T175569_2 - 4.1e-16 58.8 220.5 0.0017 18.5 5.7 17.4 15 1 0 15 15 15 11 EGF-like domain TB PF00683.15 T175569_2 - 9.5e-14 50.7 29.4 2.9e-12 45.9 3.9 4.4 4 0 0 4 4 4 2 TB domain FXa_inhibition PF14670.4 T175569_2 - 4e-13 49.3 220.6 0.00041 20.5 7.3 17.0 14 4 3 17 17 17 12 Coagulation Factor Xa inhibitory site EGF_2 PF07974.11 T175569_2 - 0.00058 20.0 4.2 0.00058 20.0 4.2 16.5 15 1 1 16 16 16 7 EGF-like domain ABC_trans_CmpB PF06541.9 T106180_3 - 3.4e-08 33.7 10.3 3.4e-08 33.7 10.3 1.5 2 0 0 2 2 2 1 Putative ABC-transporter type IV CLAMP PF14769.4 T130461_1 - 4.1e-05 23.8 0.0 7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 DUF1690 PF07956.9 T130461_1 - 0.068 13.5 0.9 0.86 9.9 0.1 2.2 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) DUF883 PF05957.11 T130461_1 - 4.1 7.9 7.2 26 5.4 2.9 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) GLTSCR1 PF15249.4 T177967_1 - 2.3e-33 114.5 0.6 3.6e-33 113.9 0.6 1.3 1 0 0 1 1 1 1 Conserved region of unknown function on GLTSCR protein Glyco_hydro_38 PF01074.20 T122179_1 - 1.5e-106 355.9 0.3 1.9e-106 355.5 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.9 T122179_1 - 6.6e-24 83.9 0.0 1.3e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38C PF07748.11 T122179_1 - 1.7e-12 47.0 0.0 2.8e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro_38C PF07748.11 T122179_2 - 4.7e-63 213.7 0.0 6.2e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Ets PF00178.20 T056948_1 - 2.6e-29 101.4 0.4 5.7e-29 100.3 0.4 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 T056948_1 - 3.2e-28 97.4 0.9 5.4e-28 96.7 0.9 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Cadherin PF00028.15 T163531_1 - 1.3e-64 214.5 12.9 1.9e-16 60.1 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 T163531_1 - 1.9e-48 164.0 1.6 1e-46 158.3 0.2 2.4 2 0 0 2 2 2 2 Cadherin cytoplasmic region Cadherin_2 PF08266.10 T163531_1 - 2.4e-07 30.3 0.0 0.084 12.6 0.0 4.1 3 1 0 3 3 3 3 Cadherin-like Myosin_tail_1 PF01576.17 T141478_2 - 0 1701.7 316.3 0 1701.5 316.3 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 T141478_2 - 0 1021.0 0.9 0 1021.0 0.9 2.4 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_N PF02736.17 T141478_2 - 2.6e-12 46.2 0.1 5.7e-12 45.1 0.1 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ADIP PF11559.6 T141478_2 - 0.00018 21.5 20.8 0.00018 21.5 20.8 14.4 1 1 12 14 14 14 4 Afadin- and alpha -actinin-Binding IQ PF00612.25 T141478_2 - 0.0002 20.8 0.2 0.00066 19.1 0.2 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_22 PF13401.4 T141478_2 - 0.17 12.0 0.0 0.17 12.0 0.0 4.9 4 0 0 4 4 4 0 AAA domain SK_channel PF03530.12 T170524_2 - 5.4e-48 161.6 0.3 5.4e-48 161.6 0.3 2.1 2 0 0 2 2 2 1 Calcium-activated SK potassium channel CaMBD PF02888.14 T170524_2 - 1.1e-35 121.6 6.2 1.8e-35 120.9 6.2 1.4 1 0 0 1 1 1 1 Calmodulin binding domain Ion_trans_2 PF07885.14 T170524_2 - 1.1e-12 47.6 3.1 1.1e-12 47.6 3.1 1.8 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.29 T170524_2 - 0.0014 17.8 1.4 0.0026 16.9 1.4 1.4 1 0 0 1 1 1 1 Ion transport protein IRK PF01007.18 T170524_2 - 0.41 9.4 2.1 0.62 8.8 2.1 1.2 1 0 0 1 1 1 0 Inward rectifier potassium channel ParcG PF10274.7 T262155_3 - 1e-19 71.2 1.2 5.9e-19 68.8 0.1 2.3 2 1 1 3 3 3 1 Parkin co-regulated protein EPTP PF03736.15 T340257_3 - 2.8e-70 231.9 4.4 4.9e-11 42.3 0.0 7.3 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.4 T340257_3 - 2.8e-16 58.9 18.6 3.4e-11 42.6 9.0 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_5 PF13306.4 T340257_3 - 0.00062 19.6 0.0 0.001 18.9 0.0 1.2 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRRCT PF01463.22 T340257_3 - 0.0029 17.9 0.6 0.025 15.0 0.6 2.8 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_4 PF12799.5 T340257_3 - 0.0042 17.3 3.0 0.0042 17.3 3.0 2.1 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 T340257_3 - 0.012 15.0 0.3 0.019 14.3 0.3 1.2 1 0 0 1 1 1 0 Leucine-rich repeat BTG PF07742.10 T083933_3 - 8.5e-42 141.5 0.0 1.3e-41 140.9 0.0 1.3 1 0 0 1 1 1 1 BTG family zf-H2C2_2 PF13465.4 T354492_1 - 9e-107 345.0 105.0 8.4e-08 32.2 0.2 18.8 18 0 0 18 18 18 16 Zinc-finger double domain zf-C2H2 PF00096.24 T354492_1 - 1.2e-84 274.2 117.3 3.7e-06 27.0 0.4 18.5 17 0 0 17 17 17 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T354492_1 - 8.6e-33 110.0 128.0 0.017 15.8 0.4 19.5 18 0 0 18 18 18 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T354492_1 - 2.6e-14 52.6 108.6 0.011 15.6 1.0 17.2 18 0 0 18 18 18 12 C2H2-type zinc finger COMM_domain PF07258.12 T354492_1 - 3.3e-14 52.6 0.0 7.4e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 COMM domain Zn-ribbon_8 PF09723.8 T354492_1 - 1.3e-09 37.8 85.9 0.014 15.3 1.9 11.6 7 2 7 14 14 14 11 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T354492_1 - 0.00016 21.7 66.2 1.7 9.0 0.1 16.0 17 0 0 17 17 17 4 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 T354492_1 - 0.0065 16.3 60.7 18 5.3 0.2 16.5 17 0 0 17 17 17 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 T354492_1 - 0.34 11.6 70.7 2.5 8.8 4.4 9.3 2 1 8 11 11 11 0 zinc-ribbon family zf-H2C2_2 PF13465.4 T354492_3 - 3.3e-90 292.7 90.3 5.1e-08 32.9 0.8 15.4 15 0 0 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 T354492_3 - 3.9e-52 171.8 107.2 0.00031 20.9 2.1 15.3 15 0 0 15 15 15 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T354492_3 - 5.6e-23 79.5 95.3 0.022 15.4 0.3 15.3 13 0 0 13 13 13 12 C2H2-type zinc finger KRAB PF01352.25 T354492_3 - 1.7e-18 65.9 0.1 3.3e-18 64.9 0.1 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 T354492_3 - 2.5e-06 27.4 57.5 0.16 12.0 1.9 8.5 5 2 3 9 9 9 8 Zinc ribbon domain zf-C2H2_6 PF13912.4 T354492_3 - 0.0002 21.1 71.5 0.22 11.4 0.2 12.3 13 0 0 13 13 13 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T354492_3 - 0.0068 16.6 41.4 0.3 11.3 0.1 11.0 12 0 0 12 12 12 2 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T354492_3 - 0.29 11.8 38.9 3.7 8.2 1.0 6.8 1 1 5 6 6 6 0 zinc-ribbon family DUF2358 PF10184.7 T300535_1 - 3.2e-32 111.0 1.2 4.7e-32 110.5 1.2 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) Ribosomal_S18 PF01084.18 T300535_1 - 1.2e-13 50.9 0.1 2.4e-13 50.0 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 Acetyltransf_16 PF05301.9 T300535_3 - 1.5e-75 252.6 0.0 2e-75 252.2 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.5 T300535_3 - 0.034 14.5 0.0 0.066 13.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 T300535_3 - 0.078 13.1 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Ubiq_cyt_C_chap PF03981.10 T216799_1 - 2.9e-16 59.7 0.2 4.2e-16 59.2 0.2 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Glyco_transf_90 PF05686.10 T248896_2 - 1.3e-120 402.9 1.2 1.7e-120 402.4 1.2 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.4 T248896_2 - 0.14 12.4 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 CCDC144C PF14915.4 T158904_2 - 1.1e-112 376.0 54.4 1.1e-112 376.0 54.4 3.1 3 0 0 3 3 3 1 CCDC144C protein coiled-coil region Ank_2 PF12796.5 T158904_2 - 3.3e-30 104.4 15.9 9.5e-10 38.8 0.9 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T158904_2 - 4e-28 97.3 4.0 1.2e-08 35.1 0.1 5.7 2 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 T158904_2 - 2.7e-25 87.9 7.9 1.4e-09 37.9 0.6 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 T158904_2 - 8.3e-18 63.9 3.3 0.00027 21.1 0.0 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.4 T158904_2 - 9.2e-17 59.3 7.6 0.00028 20.9 0.1 6.5 7 0 0 7 7 7 4 Ankyrin repeat Keratin_B2_2 PF13885.4 T159768_1 - 5 7.0 9.5 9.2 6.2 9.5 1.4 1 0 0 1 1 1 0 Keratin, high sulfur B2 protein CtIP_N PF10482.7 T159768_3 - 3.2e-53 178.8 21.8 1.3e-52 176.8 21.8 2.1 1 0 0 1 1 1 1 Tumour-suppressor protein CtIP N-terminal domain SAE2 PF08573.8 T159768_3 - 6.7e-05 23.8 0.5 6.7e-05 23.8 0.5 5.4 4 1 1 5 5 5 2 DNA repair protein endonuclease SAE2/CtIP C-terminus DUF3513 PF12026.6 T101356_1 - 1.4e-50 171.8 0.0 2e-50 171.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3513) MFS_1 PF07690.14 T101356_1 - 2.3e-17 62.8 23.8 6.9e-10 38.2 7.2 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 T101356_1 - 1.3e-16 60.4 6.6 1.9e-16 59.8 6.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter zf-LITAF-like PF10601.7 T101356_1 - 0.057 13.6 5.7 0.026 14.6 1.2 2.7 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain TRI12 PF06609.11 T101356_1 - 0.22 9.8 9.3 0.19 10.0 0.8 2.1 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Myosin_head PF00063.19 T141720_1 - 1.2e-285 948.9 6.6 1.2e-285 948.9 6.6 3.0 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 T141720_1 - 2.1e-161 539.0 272.8 2.6e-161 538.7 272.8 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 T141720_1 - 8.3e-12 44.6 1.9 2.2e-11 43.2 1.9 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 T141720_1 - 0.00014 21.3 75.6 0.015 14.5 3.3 8.9 2 2 5 9 9 9 7 Reovirus sigma C capsid protein IQ PF00612.25 T141720_1 - 0.014 15.0 0.5 0.058 13.1 0.4 2.2 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_22 PF13401.4 T141720_1 - 0.12 12.6 0.0 0.12 12.6 0.0 5.6 4 2 1 6 6 6 0 AAA domain AAA_16 PF13191.4 T141720_1 - 0.38 11.0 0.0 0.38 11.0 0.0 6.1 2 1 2 4 4 4 0 AAA ATPase domain Bradykinin PF06753.10 T141720_1 - 0.95 9.1 2.6 3.3 7.4 2.6 2.0 1 0 0 1 1 1 0 Bradykinin PRK PF00485.16 T141720_1 - 7.1 6.2 8.2 2.7 7.5 0.2 3.6 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family Vps26 PF03643.13 T225873_3 - 3.2e-27 95.1 0.0 4.4e-27 94.7 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 ASH PF15780.3 T240261_2 - 2.3e-13 50.1 0.1 6.6 6.9 0.0 9.4 10 0 0 10 10 10 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.4 T240261_2 - 1.7e-05 24.7 0.1 11 6.1 0.0 5.9 7 0 0 7 7 7 2 Flagellar-associated PapD-like TMEM131_like PF12371.6 T240261_2 - 0.00069 19.6 0.6 1.3 9.0 0.1 5.4 6 0 0 6 6 6 1 Transmembrane protein 131-like DUF1978 PF09321.8 T240261_2 - 0.39 9.9 7.5 0.014 14.6 1.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1978) Vir_act_alpha_C PF10400.7 T240261_2 - 0.41 11.2 4.5 0.25 11.9 1.5 2.2 2 0 0 2 2 2 0 Virulence activator alpha C-term DUF4587 PF15248.4 T228365_1 - 4.5e-17 62.5 10.5 2.3e-16 60.2 10.5 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4587) 7tm_1 PF00001.19 T243183_2 - 1.3e-12 47.4 0.0 2.6e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PARP PF00644.18 T243183_3 - 6.5e-56 189.1 0.0 1.1e-55 188.4 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.12 T243183_3 - 1.2e-39 135.4 0.4 2.6e-39 134.3 0.1 1.7 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.13 T243183_3 - 1.3e-27 95.5 3.6 2.5e-27 94.6 3.6 1.5 1 0 0 1 1 1 1 WGR domain 4_1_CTD PF05902.11 T217105_1 - 4.4e-32 110.3 3.1 8e-32 109.5 3.1 1.4 1 0 0 1 1 1 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.8 T217105_1 - 3.2e-24 85.0 0.0 5.7e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain SAB PF04382.11 T217105_1 - 1.7e-21 75.9 3.1 4.2e-21 74.6 3.1 1.7 1 0 0 1 1 1 1 SAB domain FERM_N PF09379.8 T217105_1 - 1.2e-19 69.9 0.1 2.7e-19 68.7 0.1 1.6 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.16 T217105_1 - 1.5e-19 70.4 0.0 3.1e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 FERM central domain FA PF08736.9 T217105_1 - 1.2e-17 63.6 2.6 4.4e-17 61.8 2.6 2.1 1 0 0 1 1 1 1 FERM adjacent (FA) AAR2 PF05282.9 T217105_3 - 4.4e-105 351.8 0.0 5.7e-105 351.5 0.0 1.1 1 0 0 1 1 1 1 AAR2 protein Med23 PF11573.6 T311366_1 - 5.5e-57 193.2 1.7 6.7e-57 192.9 1.7 1.0 1 0 0 1 1 1 1 Mediator complex subunit 23 Med23 PF11573.6 T311366_2 - 0 1829.9 2.0 0 1829.7 2.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 23 fn3 PF00041.19 T186789_3 - 1.2e-11 44.6 0.2 2.5e-11 43.6 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain DUF4808 PF16066.3 T186789_3 - 0.0014 19.2 0.1 0.0029 18.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4808) ATG13 PF10033.7 T058015_2 - 1.2e-12 47.8 0.0 1e-06 28.4 0.1 2.4 1 1 1 2 2 2 2 Autophagy-related protein 13 DUF2457 PF10446.7 T321213_1 - 2.8 6.9 4.0 4 6.3 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) 7tm_2 PF00002.22 T321213_2 - 2e-95 318.6 17.1 3.2e-95 318.0 17.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 T321213_2 - 5.1e-26 90.6 1.3 5.1e-26 90.6 1.3 2.2 2 0 0 2 2 2 1 Hormone receptor domain NIPSNAP PF07978.11 T364106_2 - 1.4e-29 102.2 0.5 1.4e-22 79.7 0.0 2.3 2 0 0 2 2 2 2 NIPSNAP CARD PF00619.19 T156076_3 - 5.7e-24 83.8 0.0 1.8e-23 82.2 0.0 2.0 1 0 0 1 1 1 1 Caspase recruitment domain PDZ PF00595.22 T156076_3 - 0.035 14.3 0.1 0.071 13.3 0.1 1.4 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Y_phosphatase PF00102.25 T156076_3 - 0.061 12.8 1.2 0.1 12.0 1.2 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase LPP PF04728.11 T156076_3 - 0.18 12.1 3.8 32 4.9 0.7 4.0 3 1 0 3 3 3 0 Lipoprotein leucine-zipper APG6 PF04111.10 T156076_3 - 4.6 6.4 44.8 1.7 7.8 22.2 3.1 1 1 2 3 3 3 0 Autophagy protein Apg6 SH3-RhoG_link PF16609.3 T279153_1 - 7e-145 481.4 22.8 1.3e-144 480.5 22.8 1.5 1 0 0 1 1 1 1 SH3-RhoGEF linking unstructured region RhoGEF PF00621.18 T279153_1 - 1.7e-74 249.8 3.8 1.4e-40 139.3 0.2 6.2 6 2 0 6 6 5 2 RhoGEF domain Spectrin PF00435.19 T279153_1 - 6.6e-42 142.1 87.9 1e-09 38.7 0.4 9.3 8 2 1 9 9 8 6 Spectrin repeat PH PF00169.27 T279153_1 - 3.1e-16 59.6 1.6 5.9e-07 29.8 0.2 3.3 3 0 0 3 3 3 2 PH domain PH_10 PF15411.4 T279153_1 - 7.8e-08 32.5 0.1 0.028 14.6 0.0 3.1 2 0 0 2 2 2 2 Pleckstrin homology domain SH3_1 PF00018.26 T279153_1 - 1.2e-07 31.1 0.0 2.8e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 SH3 domain CRAL_TRIO PF00650.18 T279153_1 - 9.1e-07 28.6 0.1 2.8e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.4 T279153_1 - 5.7e-06 26.3 0.0 8.4e-05 22.6 0.0 2.5 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain SH3_9 PF14604.4 T279153_1 - 0.00018 21.2 0.0 0.00049 19.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T279153_1 - 0.00047 19.7 0.0 0.0013 18.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain IQ_SEC7_PH PF16453.3 T279153_1 - 0.0015 18.4 0.5 0.045 13.6 0.0 3.2 3 0 0 3 3 3 1 PH domain PH_13 PF16652.3 T279153_1 - 0.0061 16.3 0.0 0.083 12.6 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain DUF4600 PF15372.4 T279153_1 - 0.11 12.8 0.1 0.11 12.8 0.1 5.3 4 1 1 5 5 4 0 Domain of unknown function (DUF4600) Myb_DNA-bind_4 PF13837.4 T279153_1 - 5.2 7.4 7.4 0.42 10.9 0.4 2.9 4 0 0 4 4 2 0 Myb/SANT-like DNA-binding domain Pkinase PF00069.23 T279153_2 - 7e-58 195.9 0.0 9.4e-58 195.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T279153_2 - 1.7e-25 89.7 0.0 2.6e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.14 T279153_2 - 1.1e-19 70.2 0.3 2.5e-19 69.0 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T279153_2 - 4.5e-13 49.5 0.2 4.5e-13 49.5 0.2 2.3 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 T279153_2 - 5.2e-09 36.0 0.1 1.1e-08 35.0 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T279153_2 - 1.7e-06 28.1 0.1 6.9e-06 26.2 0.1 2.1 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 T279153_2 - 0.0008 19.4 1.0 0.0067 16.4 1.0 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain Kdo PF06293.12 T279153_2 - 0.00096 18.4 0.0 0.0018 17.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SH3_1 PF00018.26 T279153_2 - 0.023 14.2 0.0 0.046 13.2 0.0 1.4 1 0 0 1 1 1 0 SH3 domain PX PF00787.22 T218677_2 - 5.2e-13 48.9 0.1 9.1e-13 48.1 0.1 1.2 1 0 0 1 1 1 1 PX domain TPR_1 PF00515.26 T218677_2 - 0.00017 21.1 0.2 0.00063 19.3 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 T218677_2 - 0.00038 20.2 1.1 0.0041 17.0 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 T218677_2 - 0.00057 20.0 0.5 0.0017 18.5 0.5 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.4 T218677_2 - 0.045 13.7 0.2 0.2 11.6 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.4 T218677_2 - 0.078 13.4 0.4 0.19 12.1 0.4 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.4 T218677_2 - 0.12 12.2 1.2 0.79 9.6 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 T218677_2 - 0.14 12.3 0.0 0.39 10.9 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Homeobox PF00046.27 T259400_3 - 1.7e-20 72.5 4.0 3.2e-20 71.6 4.0 1.5 1 0 0 1 1 1 1 Homeobox domain PDZ PF00595.22 T113456_3 - 2.3e-47 159.1 7.7 3.6e-16 59.2 0.2 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) ZU5 PF00791.18 T113456_3 - 4.4e-33 113.4 0.0 1.7e-32 111.5 0.0 1.9 2 0 0 2 2 2 1 ZU5 domain PDZ_2 PF13180.4 T113456_3 - 3e-17 62.5 4.7 3.3e-05 24.0 0.1 3.7 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.19 T113456_3 - 6.3e-13 48.7 0.0 1.1e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.15 T113456_3 - 6.2e-11 41.7 0.1 1.6e-10 40.4 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T113456_3 - 0.0026 17.2 0.1 0.023 14.2 0.0 2.7 2 0 0 2 2 2 1 SH3 domain RPOL_N PF14700.4 T113456_3 - 0.078 12.2 0.7 0.47 9.6 0.1 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal 7tm_2 PF00002.22 T156650_1 - 2.9e-73 246.1 16.2 3.1e-70 236.1 8.9 2.4 2 0 0 2 2 2 2 7 transmembrane receptor (Secretin family) HRM PF02793.20 T156650_1 - 1.3e-15 57.3 6.9 4.6e-15 55.5 6.9 2.0 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.9 T156650_1 - 0.022 13.8 5.6 0.032 13.3 5.6 1.1 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor Apidaecin PF00807.15 T156650_3 - 0.023 14.8 0.8 0.023 14.8 0.8 3.2 2 0 0 2 2 2 0 Apidaecin Integrin_beta PF00362.16 T227842_1 - 4.3e-116 386.8 0.0 5.7e-116 386.3 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 T227842_1 - 6.8e-16 57.5 0.5 1.1e-15 56.8 0.5 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 T227842_1 - 1.3e-15 57.5 2.4 1.3e-15 57.5 2.4 2.6 2 0 0 2 2 2 1 Integrin beta tail domain PSI_integrin PF17205.1 T227842_1 - 2e-12 46.6 12.3 3e-12 46.0 6.5 3.4 2 0 0 2 2 2 1 Integrin plexin domain EGF_2 PF07974.11 T227842_1 - 0.75 10.1 95.0 0.024 14.9 11.3 6.9 4 3 2 6 6 6 0 EGF-like domain SAM_1 PF00536.28 T236681_1 - 3.3e-20 72.1 0.1 5e-20 71.6 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T236681_1 - 2.5e-12 46.6 0.1 3.9e-12 46.0 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank_2 PF12796.5 T236681_3 - 4e-19 68.9 4.4 5.6e-09 36.3 0.6 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T236681_3 - 6.5e-13 48.8 7.9 1.5e-06 28.5 0.5 5.4 1 1 5 6 6 6 4 Ankyrin repeats (many copies) FERM_f0 PF16511.3 T236681_3 - 3.1e-11 43.3 0.0 4.9e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM SH3_2 PF07653.15 T236681_3 - 7.5e-11 41.4 0.2 1.4e-10 40.5 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_5 PF13857.4 T236681_3 - 1.2e-08 34.9 8.3 0.0029 17.8 0.5 4.5 1 1 5 6 6 6 5 Ankyrin repeats (many copies) SH3_9 PF14604.4 T236681_3 - 6.3e-08 32.2 0.0 1.3e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.28 T236681_3 - 1.7e-07 31.3 10.6 0.0033 17.7 0.0 5.3 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.4 T236681_3 - 5.1e-06 26.3 4.5 1.7 9.3 0.0 6.2 6 0 0 6 6 6 2 Ankyrin repeat PDZ PF00595.22 T236681_3 - 5.1e-06 26.6 0.0 1.1e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_1 PF00018.26 T236681_3 - 6.6e-05 22.3 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain Pkinase PF00069.23 T111538_1 - 4.7e-76 255.5 0.0 6e-76 255.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T111538_1 - 6.6e-34 117.2 0.0 9.4e-34 116.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.27 T111538_1 - 1.4e-15 57.6 0.1 2.2e-15 56.9 0.1 1.3 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.22 T111538_1 - 6.1e-10 39.5 2.9 1.5e-09 38.2 2.9 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 T111538_1 - 5.4e-07 29.1 0.0 1.2e-06 28.0 0.0 1.5 2 0 0 2 2 2 1 Kinase-like PH_11 PF15413.4 T111538_1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain BTB PF00651.29 T010033_2 - 3.3e-12 46.5 0.0 8.3e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 T010033_3 - 0.00024 21.0 0.0 0.00039 20.3 0.0 1.2 1 0 0 1 1 1 1 BTB And C-terminal Kelch FYVE PF01363.19 T043126_1 - 3e-20 72.0 7.7 5.5e-20 71.1 7.7 1.5 1 0 0 1 1 1 1 FYVE zinc finger ADK_lid PF05191.12 T043126_1 - 0.07 13.0 6.2 0.18 11.7 6.2 1.7 1 0 0 1 1 1 0 Adenylate kinase, active site lid HypA PF01155.17 T043126_1 - 0.49 10.3 3.5 0.97 9.3 3.5 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA IncA PF04156.12 T043126_1 - 0.89 9.2 29.0 1.6 8.3 29.0 1.4 1 0 0 1 1 1 0 IncA protein zf-RING_5 PF14634.4 T043126_1 - 2.5 8.0 13.2 5.7 6.9 13.2 1.7 1 0 0 1 1 1 0 zinc-RING finger domain DUF724 PF05266.12 T043126_1 - 2.9 7.5 27.4 0.044 13.5 10.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) RUN PF02759.17 T043126_3 - 7.2e-11 42.1 0.0 9e-05 22.3 0.0 2.6 1 1 1 2 2 2 2 RUN domain DUF972 PF06156.11 T043126_3 - 0.0025 18.3 6.9 0.0025 18.3 6.9 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF972) GIT_CC PF16559.3 T043126_3 - 0.005 16.7 4.3 0.005 16.7 4.3 2.0 2 0 0 2 2 2 1 GIT coiled-coil Rho guanine nucleotide exchange factor Trimer_CC PF08954.9 T043126_3 - 0.032 13.6 0.1 0.92 9.0 0.0 2.5 2 0 0 2 2 2 0 Trimerisation motif bZIP_1 PF00170.19 T043126_3 - 1.2 9.1 11.6 0.16 12.0 2.4 3.3 2 1 1 3 3 3 0 bZIP transcription factor HLH PF00010.24 T345368_2 - 3.9e-11 42.6 0.0 7e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain LRR_9 PF14580.4 T345368_2 - 1.8e-08 34.0 3.6 2.9e-08 33.3 3.6 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 T345368_2 - 0.18 12.1 14.2 28 5.1 8.3 3.6 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T345368_2 - 0.18 11.5 7.7 0.61 9.8 3.7 2.9 3 0 0 3 3 3 0 Leucine rich repeat MFS_1 PF07690.14 T017973_1 - 2.4e-17 62.8 34.0 1.9e-09 36.8 20.6 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily IQ PF00612.25 T118491_3 - 0.006 16.1 0.3 0.006 16.1 0.3 3.3 3 0 0 3 3 3 1 IQ calmodulin-binding motif CAGE1 PF15066.4 T124481_2 - 0.089 11.3 0.1 0.12 10.9 0.1 1.1 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family DUF4472 PF14739.4 T124481_3 - 4.4e-24 85.2 1.8 4.4e-24 85.2 1.8 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4472) Glyco_transf_8 PF01501.18 T257850_2 - 0.00013 21.5 0.0 0.00021 20.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 FH2 PF02181.21 T134538_1 - 4.3e-67 226.7 0.2 5.6e-67 226.3 0.2 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Hairy_orange PF07527.11 T134538_1 - 0.031 14.3 4.3 1.2 9.2 0.5 2.7 2 0 0 2 2 2 0 Hairy Orange FH2 PF02181.21 T134538_3 - 1.2e-16 60.7 0.0 1.7e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain V-set PF07686.15 T176011_3 - 3.2e-11 43.2 0.0 6.1e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T176011_3 - 0.003 18.0 0.0 0.0079 16.7 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Podoplanin PF05808.9 T176011_3 - 0.14 12.1 0.1 0.26 11.3 0.1 1.4 1 0 0 1 1 1 0 Podoplanin I-set PF07679.14 T176011_3 - 0.2 11.6 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain DUF1725 PF08333.9 T363263_1 - 0.016 14.7 0.3 0.05 13.1 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) zf-H2C2_2 PF13465.4 T363263_3 - 9.4e-86 278.6 107.5 1.2e-08 34.9 0.8 14.6 13 1 1 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 T363263_3 - 5.6e-60 196.5 125.2 3.7e-06 26.9 1.3 16.6 16 0 0 16 16 16 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T363263_3 - 2.5e-32 108.6 107.9 0.00077 20.0 0.8 15.7 15 0 0 15 15 15 11 C2H2-type zinc finger KRAB PF01352.25 T363263_3 - 1.1e-21 76.1 0.5 2.2e-21 75.1 0.5 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T363263_3 - 2.2e-16 59.3 89.7 0.0015 18.3 1.3 12.2 12 0 0 12 12 12 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T363263_3 - 0.00014 21.8 63.7 0.14 12.2 3.0 8.0 6 1 4 10 10 10 5 Zinc ribbon domain DUF3268 PF11672.6 T363263_3 - 0.00079 19.6 29.5 0.13 12.4 1.5 5.6 5 1 0 5 5 5 3 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 T363263_3 - 1.7 9.3 48.8 5.5 7.7 3.0 7.0 2 1 2 7 7 7 0 zinc-ribbon family MRP-S32 PF10210.7 T270354_1 - 1.5e-10 41.4 0.6 2.4e-10 40.7 0.6 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 MRP-S32 PF10210.7 T270354_2 - 2.3e-07 31.2 0.0 3.8e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 MFS_2 PF13347.4 T047849_2 - 0.061 11.7 0.6 0.089 11.2 0.6 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein MFS_2 PF13347.4 T047849_3 - 7.3e-16 57.6 3.5 8.4e-11 40.9 0.5 2.1 2 0 0 2 2 2 2 MFS/sugar transport protein START PF01852.17 T063510_2 - 7e-09 35.3 0.1 1.1e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 START domain DUF1501 PF07394.10 T063510_2 - 0.76 8.6 3.5 1.1 8.1 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) SAM_1 PF00536.28 T063510_3 - 1.1e-10 41.7 0.1 1.7e-10 41.1 0.1 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T063510_3 - 2.9e-10 40.0 0.0 4.9e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Plexin_cytopl PF08337.10 T382322_2 - 1.3e-218 727.0 0.0 1.7e-218 726.7 0.0 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.17 T382322_2 - 7e-45 153.4 0.0 9.5e-45 153.0 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 T382322_2 - 2e-34 117.4 0.0 5.6e-10 39.0 0.0 4.8 4 1 0 4 4 4 4 IPT/TIG domain PSI PF01437.23 T382322_2 - 8.6e-16 58.1 46.5 2e-09 37.7 14.0 4.0 3 0 0 3 3 3 3 Plexin repeat Pkinase PF00069.23 T382322_3 - 2.9e-40 138.2 0.0 3e-20 72.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 T382322_3 - 5e-10 39.0 0.0 2.6e-07 30.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Myosin_head PF00063.19 T141746_2 - 8.2e-287 952.8 6.6 8.2e-287 952.8 6.6 3.3 3 1 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 T141746_2 - 1.5e-165 552.8 268.6 1.8e-165 552.4 268.6 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 T141746_2 - 6.4e-14 51.4 1.8 1.8e-13 49.9 1.8 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 T141746_2 - 1.6e-06 27.7 69.0 0.024 13.9 1.1 9.2 1 1 10 11 11 11 7 Reovirus sigma C capsid protein IQ PF00612.25 T141746_2 - 0.0053 16.3 2.9 0.02 14.5 0.6 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif AAA_22 PF13401.4 T141746_2 - 0.1 12.7 0.0 0.1 12.7 0.0 5.8 4 2 1 5 5 5 0 AAA domain AAA_16 PF13191.4 T141746_2 - 0.45 10.8 0.0 0.45 10.8 0.0 6.2 3 2 0 3 3 3 0 AAA ATPase domain MYCBPAP PF14646.4 T150493_1 - 1.5e-33 116.2 4.2 2.2e-33 115.8 4.2 1.1 1 0 0 1 1 1 1 MYCBP-associated protein family MYCBPAP PF14646.4 T150493_2 - 1.9e-98 330.2 0.0 2.5e-98 329.7 0.0 1.1 1 0 0 1 1 1 1 MYCBP-associated protein family SMC_N PF02463.17 T235172_1 - 8.3e-20 71.0 25.4 1e-19 70.7 25.4 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.4 T235172_1 - 4.1e-08 33.1 26.0 1.3e-07 31.4 26.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.4 T235172_1 - 1.6e-07 31.9 49.9 0.0017 18.8 49.9 3.2 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.4 T235172_1 - 4.7e-07 29.8 0.3 4.7e-07 29.8 0.3 1.8 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 T235172_1 - 1.1e-05 24.9 0.0 1.9e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_hinge PF06470.11 T235172_2 - 1.5e-19 70.3 0.0 3.2e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.17 T235172_2 - 3.8e-07 29.6 0.1 1.4e-06 27.8 0.1 1.9 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain polyprenyl_synt PF00348.15 T033449_1 - 1.7e-63 214.0 0.0 2.1e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase CAP_GLY PF01302.23 T033449_3 - 5.6e-18 64.6 0.5 9.5e-18 63.8 0.5 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.5 T033449_3 - 2.5e-16 59.3 14.4 0.00076 19.7 0.3 5.2 4 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T033449_3 - 1.4e-09 37.4 9.8 0.00016 21.3 0.1 4.4 3 1 2 5 5 5 4 Leucine rich repeat LRR_9 PF14580.4 T033449_3 - 9.3e-08 31.6 2.6 1.7e-06 27.6 1.0 2.7 1 1 0 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.4 T033449_3 - 0.069 13.1 9.1 40 4.5 0.1 6.0 7 0 0 7 7 7 0 Leucine Rich repeat MACPF PF01823.17 T025563_3 - 9.2e-06 25.8 0.0 1.7e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 MAC/Perforin domain RasGEF PF00617.17 T319777_1 - 2.3e-49 167.7 0.7 3.6e-49 167.1 0.7 1.3 1 0 0 1 1 1 1 RasGEF domain Transposase_1 PF01359.16 T319777_1 - 2.3e-21 75.3 0.1 5.8e-21 74.0 0.1 1.7 1 0 0 1 1 1 1 Transposase (partial DDE domain) RasGEF_N PF00618.18 T319777_1 - 7.7e-12 45.3 0.3 2.1e-11 43.8 0.3 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 T319777_1 - 0.22 12.1 0.8 0.6 10.7 0.1 2.1 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain Tap-RNA_bind PF09162.8 T377835_2 - 2.1e-27 94.7 0.6 1.2e-26 92.2 0.6 2.0 1 1 0 1 1 1 1 Tap, RNA-binding zf-BED PF02892.13 T377835_2 - 0.041 13.8 0.6 1.4 8.9 0.1 2.4 2 0 0 2 2 2 0 BED zinc finger zf-met PF12874.5 T377835_3 - 6.6e-13 48.5 20.0 1.1e-06 28.7 0.1 4.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-U1 PF06220.10 T377835_3 - 7.9e-07 28.6 4.5 0.0071 16.0 0.2 3.7 3 0 0 3 3 3 2 U1 zinc finger zf-C2H2 PF00096.24 T377835_3 - 0.0015 18.7 0.7 0.0015 18.7 0.7 3.4 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 T377835_3 - 0.013 15.7 17.3 0.015 15.5 0.1 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 T377835_3 - 0.077 13.7 6.2 0.21 12.4 0.3 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger PMT PF02366.16 T367884_1 - 7e-06 25.7 8.6 2.7e-05 23.7 3.9 2.1 2 0 0 2 2 2 2 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT PF02366.16 T367884_2 - 3e-61 207.0 10.9 4.5e-61 206.4 10.9 1.1 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_2 PF13231.4 T367884_2 - 7.3e-05 22.9 9.4 0.00011 22.3 9.4 1.1 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.3 T367884_3 - 2.5e-51 174.0 8.4 3.3e-51 173.6 8.4 1.2 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.17 T367884_3 - 1.9e-09 37.5 0.0 2.9e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 MIR domain PDZ PF00595.22 T244721_3 - 4.2e-49 164.7 3.4 3.2e-13 49.7 0.0 4.9 5 0 0 5 5 5 4 PDZ domain (Also known as DHR or GLGF) MAGI_u5 PF16666.3 T244721_3 - 9.1e-36 122.8 9.7 9.1e-36 122.8 9.7 3.2 2 0 0 2 2 2 1 Unstructured region on MAGI MAGI_u1 PF16663.3 T244721_3 - 1.1e-31 108.4 3.1 5.4e-31 106.2 3.1 2.3 1 0 0 1 1 1 1 Unstructured region on MAGI PDZ_2 PF13180.4 T244721_3 - 3e-21 75.4 0.0 0.00087 19.4 0.0 5.1 5 0 0 5 5 5 4 PDZ domain WW PF00397.24 T244721_3 - 4.7e-18 64.7 3.9 6.8e-10 38.6 0.4 2.7 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 T244721_3 - 2.9e-10 40.0 0.0 2.9e-10 40.0 0.0 2.2 2 0 0 2 2 2 1 Guanylate kinase Tricorn_PDZ PF14685.4 T244721_3 - 0.00081 19.2 3.0 2.4 8.1 0.0 3.8 4 0 0 4 4 4 2 Tricorn protease PDZ domain Serglycin PF04360.10 T244721_3 - 0.061 13.1 0.4 0.12 12.1 0.4 1.4 1 0 0 1 1 1 0 Serglycin DUF853 PF05872.10 T244721_3 - 1.8 6.9 4.0 3.1 6.2 4.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) RhoGEF PF00621.18 T002249_1 - 1.1e-34 120.2 0.0 1.5e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain UNC-79 PF14776.4 T002249_1 - 8.4e-05 21.3 1.5 0.00013 20.7 1.5 1.1 1 0 0 1 1 1 1 Cation-channel complex subunit UNC-79 PH_5 PF15405.4 T002249_1 - 0.016 15.2 0.1 0.029 14.4 0.1 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain PH_10 PF15411.4 T002249_1 - 0.017 15.2 0.3 0.035 14.2 0.0 1.6 2 0 0 2 2 2 0 Pleckstrin homology domain PH_13 PF16652.3 T002249_1 - 0.099 12.4 0.2 1 9.1 0.1 2.4 2 1 0 2 2 2 0 Pleckstrin homology domain Death PF00531.20 T002249_2 - 1.7e-14 53.6 0.0 3.1e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Death domain TNFR_c6 PF00020.16 T002249_2 - 2e-06 28.0 7.2 2e-06 28.0 7.2 8.2 6 1 0 7 7 7 2 TNFR/NGFR cysteine-rich region Peptidase_M10 PF00413.22 T101079_3 - 2.5e-58 196.3 0.0 3.6e-58 195.7 0.0 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 T101079_3 - 1e-54 182.1 16.0 1e-13 50.9 0.3 4.7 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.6 T101079_3 - 7.2e-24 83.4 0.0 1.3e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.16 T101079_3 - 5.1e-11 42.5 0.2 1e-10 41.5 0.2 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 T101079_3 - 0.0071 15.9 0.7 1.1 8.7 0.0 2.1 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Metallopep PF12044.6 T101079_3 - 0.072 11.5 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M54 PF07998.9 T101079_3 - 0.08 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 DUF4953 PF16313.3 T101079_3 - 0.11 11.6 0.1 0.16 11.0 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_3 PF13582.4 T101079_3 - 0.25 11.7 0.1 0.42 11.0 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like SKG6 PF08693.8 T101079_3 - 6.4 6.1 7.1 13 5.1 7.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RHD_DNA_bind PF00554.20 T101845_1 - 3e-20 72.7 0.0 5.3e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 T101845_1 - 3.1e-19 68.8 0.0 5.8e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 Rel homology dimerisation domain TIG PF01833.22 T101845_1 - 2.8e-06 27.2 0.0 5.5e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 IPT/TIG domain DUF3915 PF13054.4 T101845_2 - 4 7.3 5.6 7.6 6.4 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 T274830_1 - 2e-05 24.9 7.3 3.7e-05 24.0 7.3 1.3 1 0 0 1 1 1 1 FAM27 D and E protein family FAM27 PF15832.3 T274830_2 - 0.0014 19.0 15.5 0.0025 18.2 15.5 1.3 1 0 0 1 1 1 1 FAM27 D and E protein family Reprolysin PF01421.17 T274830_3 - 8.3e-44 149.8 0.2 2.2e-43 148.3 0.2 1.7 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 T274830_3 - 1.1e-32 112.7 8.9 1.1e-32 112.7 8.9 3.3 2 1 1 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 T274830_3 - 1.7e-19 70.2 26.0 1.7e-19 70.2 26.0 3.8 3 0 0 3 3 3 1 Disintegrin Pep_M12B_propep PF01562.17 T274830_3 - 1.3e-17 64.2 0.0 2.9e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 T274830_3 - 1.8e-06 28.1 0.0 3.5e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T274830_3 - 2.7e-06 27.8 0.0 4.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like FAM27 PF15832.3 T274830_3 - 5.4e-05 23.5 7.2 0.00014 22.2 7.2 1.6 1 0 0 1 1 1 1 FAM27 D and E protein family Reprolysin_2 PF13574.4 T274830_3 - 0.00056 19.7 0.2 0.0011 18.8 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T274830_3 - 0.0015 18.1 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like zf-CCCH PF00642.22 T173944_1 - 0.027 14.3 2.4 0.076 12.8 2.4 1.8 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH PF00642.22 T173944_3 - 0.0083 15.9 0.5 0.036 13.9 0.5 2.2 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) tRNA_int_endo_N PF02778.12 T238170_1 - 1.9e-17 62.5 1.0 2.5e-12 46.2 0.3 2.3 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain tRNA_int_endo PF01974.15 T238170_1 - 4.6e-15 55.3 0.2 9.3e-15 54.3 0.2 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain LRR_8 PF13855.4 T083814_2 - 1.9e-36 123.5 17.4 2.5e-14 52.6 1.8 4.5 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 T083814_2 - 2.7e-15 56.0 23.4 0.00093 19.4 1.4 6.3 3 1 5 8 8 8 6 Leucine Rich repeats (2 copies) LRRNT PF01462.16 T083814_2 - 8.7e-10 37.9 5.6 3.7e-09 35.9 5.6 2.2 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 T083814_2 - 5.9e-08 32.3 4.3 0.00025 20.5 1.3 2.8 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.31 T083814_2 - 2 9.1 9.5 1.8e+02 3.1 0.0 5.7 4 1 0 4 4 4 0 Leucine Rich Repeat ORMDL PF04061.12 T146889_1 - 4.9e-52 175.2 4.7 7.7e-52 174.6 4.7 1.3 1 0 0 1 1 1 1 ORMDL family Gasdermin PF04598.10 T146889_1 - 4.7e-13 48.8 2.2 7.2e-13 48.2 2.2 1.1 1 0 0 1 1 1 1 Gasdermin family Gasdermin PF04598.10 T146889_2 - 1.2e-26 93.6 0.0 1.7e-26 93.2 0.0 1.1 1 0 0 1 1 1 1 Gasdermin family HAGH_C PF16123.3 T124510_2 - 1.6e-20 73.2 0.0 2.4e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 T124510_2 - 9.7e-10 38.6 1.4 9.7e-10 38.6 1.4 2.6 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 T124510_2 - 0.0014 18.0 0.1 0.0027 17.1 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Pkinase PF00069.23 T052720_2 - 3.2e-71 239.6 0.0 4.6e-71 239.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T052720_2 - 8.7e-39 133.2 0.0 1.1e-38 132.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 T052720_2 - 0.00084 19.2 0.0 0.0047 16.8 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.4 T052720_2 - 0.041 13.1 0.0 0.06 12.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.18 T052720_2 - 0.086 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.12 T052720_2 - 0.16 11.2 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ACTH_domain PF00976.16 T228111_1 - 1.8 8.5 18.9 11 5.9 1.6 4.1 3 0 0 3 3 3 0 Corticotropin ACTH domain KH_1 PF00013.27 T228111_2 - 2.1e-53 177.9 13.9 2.7e-18 65.4 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 T228111_2 - 5.7e-13 48.4 7.0 0.00013 21.6 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 T228111_2 - 1.8e-06 27.6 1.1 0.029 14.1 0.3 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 T228111_2 - 0.0014 18.5 7.9 2 8.4 0.2 3.3 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.3 T228111_2 - 0.032 14.1 0.0 0.21 11.5 0.0 2.2 3 0 0 3 3 3 0 KH-like RNA-binding domain Ion_trans PF00520.29 T078160_2 - 2.5e-31 108.6 1.1 3.3e-31 108.3 1.1 1.1 1 0 0 1 1 1 1 Ion transport protein PAS_9 PF13426.5 T078160_2 - 1.1e-17 64.0 0.0 1.9e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 PAS domain Ion_trans_2 PF07885.14 T078160_2 - 5.6e-11 42.1 0.8 1.9e-10 40.5 0.6 2.0 2 0 0 2 2 2 1 Ion channel cNMP_binding PF00027.27 T078160_2 - 5.1e-07 29.5 0.0 1.1e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PAS_4 PF08448.8 T078160_2 - 2.6e-06 27.5 0.0 5.5e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.10 T078160_2 - 7e-06 26.1 0.0 1.2e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS PF00989.23 T078160_2 - 1.7e-05 24.7 0.0 3e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 PAS fold S6PP PF05116.11 T078160_2 - 0.15 11.5 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase Lbh PF15317.4 T060148_1 - 7.1e-41 139.0 0.7 1.2e-40 138.3 0.7 1.4 1 0 0 1 1 1 1 Cardiac transcription factor regulator, Developmental protein TACC PF05010.12 T049823_3 - 3.1e-84 281.6 34.2 4.4e-84 281.2 34.2 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) Skp1_POZ PF03931.13 T049823_3 - 0.024 14.6 0.4 0.058 13.5 0.4 1.6 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain DUF4602 PF15375.4 T032756_1 - 1.1e-28 100.1 6.6 1.1e-28 100.1 6.6 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4602) Fasciclin PF02469.20 T243450_1 - 1.1e-52 177.5 0.0 1.8e-17 63.6 0.0 4.2 4 0 0 4 4 4 4 Fasciclin domain EGF_3 PF12947.5 T243450_1 - 1.6e-18 66.5 90.4 1.6e-07 31.2 10.3 15.2 15 0 0 15 15 15 8 EGF domain EGF_MSP1_1 PF12946.5 T243450_1 - 0.00055 19.8 5.9 0.00055 19.8 5.9 14.1 14 0 0 14 14 14 5 MSP1 EGF domain 1 cEGF PF12662.5 T243450_1 - 0.0014 18.4 0.4 0.0014 18.4 0.4 14.8 15 1 0 15 15 15 5 Complement Clr-like EGF-like FXa_inhibition PF14670.4 T243450_1 - 0.005 17.0 3.5 0.005 17.0 3.5 19.5 12 4 5 17 17 17 4 Coagulation Factor Xa inhibitory site Fasciclin PF02469.20 T243450_3 - 3.7e-42 143.4 0.0 1.3e-18 67.3 0.0 3.5 3 1 0 3 3 3 3 Fasciclin domain EGF_3 PF12947.5 T243450_3 - 5.1e-28 96.8 150.0 2.3e-08 33.9 9.6 11.3 12 0 0 12 12 12 7 EGF domain Xlink PF00193.15 T243450_3 - 1.2e-27 96.0 0.0 4.3e-27 94.2 0.0 2.1 1 0 0 1 1 1 1 Extracellular link domain Laminin_EGF PF00053.22 T243450_3 - 0.0014 18.6 6.1 0.0014 18.6 6.1 10.7 5 3 5 10 10 10 2 Laminin EGF domain SPRR2 PF14820.4 T021234_3 - 6.1e-24 84.0 77.1 1e-23 83.2 77.1 1.4 1 0 0 1 1 1 1 Small proline-rich 2 zf-Tim10_DDP PF02953.13 T054025_1 - 9.1e-12 44.3 0.1 1.7e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 Tim10/DDP family zinc finger EIN3 PF04873.11 T054025_2 - 0.11 11.6 0.1 0.24 10.5 0.1 1.4 1 0 0 1 1 1 0 Ethylene insensitive 3 zf-C2H2_11 PF16622.3 T063189_2 - 0.13 11.9 2.2 0.4 10.3 2.2 1.8 1 0 0 1 1 1 0 zinc-finger C2H2-type Thioredoxin PF00085.18 T233027_1 - 2.4e-26 91.5 0.1 4e-26 90.8 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.4 T233027_1 - 6.5e-05 23.2 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.4 T233027_1 - 0.0013 18.8 0.1 0.0025 17.9 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like Pyr_redox_3 PF13738.4 T233027_2 - 2.9e-30 105.4 0.0 7.6e-30 104.1 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Gag_p30 PF02093.14 T233027_2 - 1.4e-15 57.2 0.0 2.9e-15 56.2 0.0 1.4 1 1 0 1 1 1 1 Gag P30 core shell protein Pyr_redox_2 PF07992.12 T233027_2 - 1.2e-06 27.9 0.0 1.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 T233027_2 - 6.6e-06 26.1 0.0 1.5e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 T233027_2 - 0.00059 19.4 0.0 0.051 13.1 0.0 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.4 T233027_2 - 0.0025 16.9 0.0 0.0047 16.0 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.12 T233027_2 - 0.0033 16.1 0.0 0.017 13.7 0.0 1.9 1 1 0 1 1 1 1 HI0933-like protein FMO-like PF00743.17 T233027_2 - 0.0084 14.4 0.0 0.014 13.7 0.0 1.2 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox PF00070.25 T233027_2 - 0.021 15.3 0.0 0.4 11.1 0.0 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF1394 PF07159.10 T351704_1 - 5.5e-151 501.9 0.2 6.6e-151 501.6 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) VWC PF00093.16 T332977_1 - 8.2e-79 259.7 280.9 6.9e-10 39.0 11.2 14.8 15 0 0 15 15 15 13 von Willebrand factor type C domain VWD PF00094.23 T332977_1 - 2.4e-36 125.3 0.0 3.4e-36 124.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type D domain TILa PF12714.5 T332977_1 - 1.7e-10 40.6 216.8 3.4e-05 23.6 2.7 14.2 14 0 0 14 14 14 10 TILa domain CFC PF09443.8 T332977_1 - 0.0024 17.6 2.6 0.0024 17.6 2.6 14.1 13 0 0 13 13 13 7 Cripto_Frl-1_Cryptic (CFC) VWC PF00093.16 T332977_3 - 1.6e-45 153.1 129.8 1.1e-08 35.2 8.3 7.7 6 1 1 7 7 7 7 von Willebrand factor type C domain TILa PF12714.5 T332977_3 - 1e-07 31.6 98.8 0.032 14.1 2.4 7.8 6 1 1 7 7 7 7 TILa domain p450 PF00067.20 T329202_2 - 1.9e-33 115.8 0.0 2.4e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 T329202_3 - 8.1e-90 301.6 0.4 1.1e-89 301.2 0.4 1.1 1 0 0 1 1 1 1 Cytochrome P450 RIIa PF02197.15 T249642_3 - 0.015 14.8 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit Anoctamin PF04547.10 T062896_3 - 5.3e-157 522.9 11.7 6.7e-157 522.6 11.7 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 T062896_3 - 1.5e-78 263.5 0.2 1.5e-78 263.5 0.2 2.8 2 1 0 2 2 2 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin UPF0182 PF03699.11 T062896_3 - 2.6 6.0 7.2 0.23 9.4 2.3 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) V-set PF07686.15 T193667_2 - 1.2e-19 70.3 0.2 1.7e-19 69.8 0.2 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T193667_2 - 9e-08 32.5 0.1 1.8e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T193667_2 - 2.3e-05 24.2 0.0 4.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 T193667_2 - 0.00016 21.6 0.1 0.0003 20.8 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T193667_2 - 0.0048 17.1 0.2 0.0088 16.2 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin domain C1-set PF07654.13 T193667_3 - 2.2e-23 82.4 0.7 3.9e-23 81.6 0.4 1.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 T193667_3 - 5.1e-05 23.7 0.3 9.9e-05 22.7 0.3 1.4 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 T193667_3 - 0.0024 17.8 0.2 0.0046 16.9 0.2 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 T193667_3 - 0.0037 17.3 0.4 0.0077 16.2 0.4 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Clat_adaptor_s PF01217.18 T121947_1 - 3.5e-39 133.8 2.4 5.3e-39 133.2 2.4 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain UPF0552 PF10574.7 T121947_2 - 2.6e-104 347.3 0.0 3.4e-104 346.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0552 Clat_adaptor_s PF01217.18 T121947_2 - 0.012 15.4 0.1 0.019 14.8 0.1 1.2 1 0 0 1 1 1 0 Clathrin adaptor complex small chain RhoGEF PF00621.18 T105916_3 - 2.4e-44 151.6 0.6 3.7e-44 151.0 0.6 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 T105916_3 - 1.8e-07 31.5 0.2 3.9e-07 30.4 0.2 1.5 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 T105916_3 - 0.021 14.9 0.9 0.16 12.1 0.9 2.1 1 1 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.3 T105916_3 - 0.11 12.3 0.2 0.2 11.4 0.2 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain Xlink PF00193.15 T121676_1 - 1.3e-123 403.6 4.7 5.6e-32 109.9 0.1 4.9 5 0 0 5 5 5 4 Extracellular link domain Lectin_C PF00059.19 T121676_1 - 7.6e-23 81.2 12.0 1.2e-19 70.9 1.5 4.8 5 0 0 5 5 5 2 Lectin C-type domain V-set PF07686.15 T121676_1 - 7.2e-11 42.1 0.0 3.4e-10 39.9 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain Sushi PF00084.18 T121676_1 - 4.6e-09 36.6 1.6 1.3e-08 35.1 1.6 1.9 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) I-set PF07679.14 T121676_1 - 0.01 15.7 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.23 T121676_1 - 0.011 15.7 0.0 0.032 14.3 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin domain Med20 PF08612.9 T303597_1 - 0.0013 18.0 0.0 0.0018 17.5 0.0 1.2 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex UCH PF00443.27 T303597_2 - 1.9e-33 115.9 0.9 2.9e-33 115.3 0.9 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Med20 PF08612.9 T303597_2 - 5.8e-22 78.0 0.0 1e-21 77.2 0.0 1.3 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex zf-UBP PF02148.17 T303597_2 - 9.4e-20 70.6 8.4 4e-19 68.6 8.4 2.2 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 T303597_2 - 2.3e-09 37.2 1.8 3e-05 23.7 0.3 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PRAP PF15314.4 T051741_3 - 7.3e-18 64.6 11.0 7.3e-18 64.6 11.0 1.9 2 0 0 2 2 2 1 Proline-rich acidic protein 1, pregnancy-specific uterine FAM124 PF15067.4 T208718_1 - 1.2e-107 358.8 0.1 1.6e-107 358.4 0.1 1.2 1 0 0 1 1 1 1 FAM124 family fn3 PF00041.19 T153746_3 - 1.6e-108 355.1 15.2 1.9e-16 60.1 0.0 8.9 8 0 0 8 8 8 8 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 T153746_3 - 8.6e-16 58.2 8.4 0.014 15.8 0.0 9.3 9 2 0 9 9 9 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 T153746_3 - 1.7e-05 24.9 0.0 0.96 9.7 0.0 4.8 4 0 0 4 4 4 2 Interferon-alpha/beta receptor, fibronectin type III TMEM154 PF15102.4 T153746_3 - 0.092 12.5 0.0 0.25 11.1 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family Cadherin_C_2 PF16492.3 T153746_3 - 0.15 12.7 1.3 30 5.4 0.1 3.2 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal Crystall PF00030.17 T006150_2 - 3.8e-130 424.2 0.2 1.1e-27 95.8 0.1 6.4 6 0 0 6 6 6 6 Beta/Gamma crystallin Ricin_B_lectin PF00652.20 T006150_2 - 7.3e-07 29.4 0.0 1.2e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Crystall_3 PF08964.8 T006150_2 - 0.011 15.7 0.0 70 3.6 0.0 4.6 5 0 0 5 5 5 0 Beta/Gamma crystallin NADH_dh_m_C1 PF15088.4 T050656_1 - 0.12 11.9 0.1 0.23 11.0 0.1 1.4 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Rifin_STEVOR PF02009.14 T050656_2 - 0.049 13.4 0.1 0.062 13.0 0.1 1.2 1 0 0 1 1 1 0 Rifin/stevor family DUF4064 PF13273.4 T050656_2 - 0.062 13.5 16.3 0.32 11.2 3.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) BatD PF13584.4 T050656_2 - 0.14 10.8 0.1 0.23 10.2 0.1 1.3 1 0 0 1 1 1 0 Oxygen tolerance EphA2_TM PF14575.4 T050656_2 - 0.15 12.7 0.0 0.97 10.2 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Bac_export_2 PF01312.17 T050656_2 - 0.65 9.0 3.6 1.1 8.3 3.6 1.3 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family Ninjurin PF04923.10 T050656_2 - 0.74 9.6 5.3 0.46 10.3 0.6 2.5 1 1 1 2 2 2 0 Ninjurin DUF2207 PF09972.7 T050656_2 - 0.87 8.2 5.4 0.73 8.4 0.7 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3671 PF12420.6 T050656_2 - 9 6.3 7.8 12 5.8 1.3 2.5 1 1 1 2 2 2 0 Protein of unknown function NYD-SP28_assoc PF14775.4 T186488_1 - 6.7e-23 80.4 7.6 6.7e-23 80.4 7.6 4.0 3 1 2 5 5 5 1 Sperm tail C-terminal domain Octopine_DH PF02317.15 T186488_1 - 3.8 7.4 9.2 0.59 10.1 1.5 2.5 1 1 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain NACHT PF05729.10 T181544_2 - 1.4e-32 112.7 0.0 3.2e-32 111.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain LRR_6 PF13516.4 T181544_2 - 3.3e-15 54.6 48.0 8.7e-05 22.1 0.2 10.7 11 0 0 11 11 11 6 Leucine Rich repeat AAA_25 PF13481.4 T181544_2 - 0.00016 21.2 0.0 0.0003 20.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 T181544_2 - 0.0011 19.2 0.0 0.0036 17.6 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.20 T181544_2 - 0.0012 17.8 0.0 0.0023 16.9 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain LRR_4 PF12799.5 T181544_2 - 0.0015 18.7 37.9 0.065 13.5 0.4 7.8 6 1 1 7 7 7 4 Leucine Rich repeats (2 copies) AAA_22 PF13401.4 T181544_2 - 0.052 13.7 0.0 0.18 11.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.14 T181544_2 - 0.053 13.3 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 IstB_IS21 PF01695.15 T181544_2 - 0.074 12.7 0.0 0.78 9.4 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein LRR_1 PF00560.31 T181544_2 - 0.15 12.5 28.6 1.5 9.5 0.4 8.9 8 1 0 8 8 8 0 Leucine Rich Repeat KRAB PF01352.25 T245515_2 - 2.2e-22 78.3 1.7 5.3e-22 77.1 1.4 1.8 2 0 0 2 2 2 1 KRAB box Paf67 PF10255.7 T233467_1 - 5.9e-176 585.3 10.4 8e-176 584.8 10.4 1.2 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.15 T233467_1 - 0.016 15.1 0.4 0.13 12.3 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 T233467_1 - 0.09 12.5 0.3 1.3 8.9 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 T233467_1 - 0.14 12.3 0.1 0.28 11.3 0.1 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Septin PF00735.16 T211685_1 - 1.6e-126 421.2 0.1 2.1e-126 420.8 0.1 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 T211685_1 - 5e-07 29.7 0.0 1.1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 T211685_1 - 5.9e-05 22.9 0.2 0.0039 17.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 T211685_1 - 6.3e-05 22.5 0.1 0.014 14.8 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.14 T211685_1 - 0.0012 18.1 0.0 0.0024 17.1 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Ras PF00071.20 T211685_1 - 0.0036 16.8 0.0 0.0062 16.0 0.0 1.3 1 0 0 1 1 1 1 Ras family Dynamin_N PF00350.21 T211685_1 - 0.0067 16.4 0.1 0.32 10.9 0.0 2.5 1 1 1 2 2 2 1 Dynamin family Roc PF08477.11 T211685_1 - 0.028 14.5 0.0 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 T211685_1 - 0.029 14.6 0.0 0.066 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 T211685_1 - 0.04 14.1 0.1 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.4 T211685_1 - 0.046 13.3 0.0 0.098 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 T211685_1 - 0.059 13.7 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Pyridoxal_deC PF00282.17 T202792_3 - 4.3e-151 502.8 0.0 5.4e-151 502.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 T202792_3 - 6.8e-05 21.8 0.0 0.00034 19.5 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 T202792_3 - 0.00088 18.5 0.0 0.0017 17.6 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.11 T202792_3 - 0.099 11.2 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS OKR_DC_1 PF01276.18 T202792_3 - 0.15 10.6 0.0 0.23 10.0 0.0 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain DegT_DnrJ_EryC1 PF01041.15 T202792_3 - 0.16 11.1 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family CBM_21 PF03370.11 T338592_2 - 4.2e-33 113.7 0.9 9.1e-33 112.7 0.9 1.6 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 T338592_2 - 2.5e-13 50.2 0.6 5.3e-13 49.2 0.6 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) zf-B_box PF00643.22 T021907_3 - 1.5e-09 37.7 6.4 1.5e-09 37.7 6.4 4.3 4 1 0 4 4 4 2 B-box zinc finger zf-RING_UBOX PF13445.4 T021907_3 - 4.9e-07 29.5 2.3 4.9e-07 29.5 2.3 3.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 T021907_3 - 7e-07 28.9 2.4 7e-07 28.9 2.4 4.0 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T021907_3 - 7.9e-07 28.7 1.3 7.9e-07 28.7 1.3 3.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T021907_3 - 1.4e-05 24.7 2.8 1.4e-05 24.7 2.8 4.7 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T021907_3 - 8.5e-05 22.5 3.5 8.5e-05 22.5 3.5 3.4 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 T021907_3 - 0.00032 20.5 1.8 0.00032 20.5 1.8 4.3 3 1 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.4 T021907_3 - 0.0063 16.6 1.7 0.0063 16.6 1.7 4.3 4 1 0 4 4 4 1 Ring finger domain fn3 PF00041.19 T021907_3 - 0.0077 16.4 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 1 Fibronectin type III domain zf-piccolo PF05715.11 T021907_3 - 3.2 7.8 22.2 7 6.8 1.7 3.9 3 0 0 3 3 3 0 Piccolo Zn-finger zf-H2C2_2 PF13465.4 T167993_3 - 6.3e-44 146.4 61.8 6.4e-07 29.4 0.8 11.2 11 0 0 11 11 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 T167993_3 - 8.7e-36 120.3 61.9 3.3e-05 24.0 0.6 13.2 13 0 0 13 13 13 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T167993_3 - 1.1e-24 84.8 55.6 0.02 15.5 0.3 12.7 11 0 0 11 11 11 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T167993_3 - 3.7e-06 27.0 28.3 0.072 13.3 0.3 7.9 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding Trm112p PF03966.14 T167993_3 - 0.00087 19.7 5.5 0.9 10.0 1.9 3.9 2 1 0 2 2 2 2 Trm112p-like protein zf-C2H2_6 PF13912.4 T167993_3 - 0.014 15.2 52.1 0.53 10.2 0.5 9.7 9 1 0 9 9 9 0 C2H2-type zinc finger XPA_N PF01286.16 T167993_3 - 0.022 14.6 27.9 3.6 7.6 0.0 8.0 8 0 0 8 8 8 0 XPA protein N-terminal zf-trcl PF13451.4 T167993_3 - 0.11 12.2 22.3 28 4.6 0.1 7.3 7 0 0 7 7 7 0 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.8 T167993_3 - 0.23 11.5 32.2 0.22 11.6 1.2 6.1 5 1 0 6 6 6 0 Zinc ribbon domain DUF3268 PF11672.6 T167993_3 - 0.51 10.6 7.0 12 6.1 0.1 2.9 2 0 0 2 2 2 0 zinc-finger-containing domain zf-C2HC_2 PF13913.4 T167993_3 - 0.67 9.8 10.5 0.51 10.2 0.8 4.3 4 0 0 4 4 4 0 zinc-finger of a C2HC-type ADK_lid PF05191.12 T167993_3 - 4 7.4 11.7 20 5.2 0.0 4.7 3 2 2 5 5 5 0 Adenylate kinase, active site lid UCH PF00443.27 T005151_3 - 6e-41 140.5 2.5 8.9e-41 139.9 2.5 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 T005151_3 - 7e-21 75.0 1.1 1.5e-20 73.9 1.1 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.10 T005151_3 - 3.2e-06 27.5 3.4 0.0053 17.2 0.0 4.0 4 1 0 4 4 4 2 DUSP domain ubiquitin PF00240.21 T005151_3 - 0.00091 18.8 0.0 0.002 17.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Tup_N PF08581.8 T366830_1 - 0.15 12.3 22.3 0.19 11.9 9.5 2.4 2 0 0 2 2 2 0 Tup N-terminal PSP1 PF04468.10 T366830_1 - 0.51 10.5 3.1 1.2 9.3 3.1 1.6 1 0 0 1 1 1 0 PSP1 C-terminal conserved region Hist_rich_Ca-bd PF10529.7 T366830_3 - 5.2 7.3 6.1 10 6.4 4.1 2.4 2 0 0 2 2 2 0 Histidine-rich Calcium-binding repeat region DUF1899 PF08953.9 T144925_1 - 1.3e-29 101.7 0.0 2.4e-29 100.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 T144925_1 - 8.3e-21 73.5 0.2 1.7e-20 72.5 0.2 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 T144925_1 - 3.8e-13 49.6 5.4 0.0012 19.5 0.2 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T144925_1 - 1.9e-07 31.1 0.1 0.0018 18.4 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DSPc PF00782.18 T144925_2 - 7.6e-33 113.0 0.0 1.4e-32 112.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.9 T144925_2 - 4.2e-10 39.3 5.1 7.8e-10 38.4 5.1 1.5 1 0 0 1 1 1 1 DEK C terminal domain Phosphodiest PF01663.20 T275461_2 - 2.8e-56 191.5 0.8 3.7e-56 191.1 0.8 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.16 T275461_2 - 0.02 14.1 0.0 0.032 13.5 0.0 1.1 1 0 0 1 1 1 0 Metalloenzyme superfamily PglZ PF08665.10 T275461_2 - 0.1 12.5 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 PglZ domain MBT PF02820.16 T008985_1 - 1e-47 160.2 0.0 9.4e-25 86.6 0.0 2.5 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 T008985_1 - 1.6e-35 121.8 0.1 3e-35 121.0 0.1 1.5 1 0 0 1 1 1 1 SLED domain AlbA_2 PF04326.12 T008985_1 - 5.4e-27 94.4 0.0 9.7e-27 93.6 0.0 1.3 1 0 0 1 1 1 1 Putative DNA-binding domain SAM_1 PF00536.28 T008985_1 - 5.7e-16 58.6 0.1 9.5e-16 57.9 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.1 T008985_1 - 2.5e-12 47.2 17.6 7.2e-12 45.7 17.6 1.9 1 0 0 1 1 1 1 RNA binding Region SAM_2 PF07647.15 T008985_1 - 7.9e-07 29.0 0.0 1.5e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 T008985_1 - 0.0054 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain zf-C3HC4_2 PF13923.4 T148075_1 - 2e-08 33.8 7.6 5.9e-08 32.3 7.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T148075_1 - 2.3e-08 33.6 7.2 2.3e-08 33.6 7.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T148075_1 - 4.3e-07 29.9 7.2 1e-06 28.7 7.2 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 T148075_1 - 1.1e-06 28.3 9.0 3.2e-06 26.9 9.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 T148075_1 - 2.4e-05 24.4 5.7 6.5e-05 23.0 5.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-Nse PF11789.6 T148075_1 - 0.0003 20.4 4.8 0.00071 19.2 4.8 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.4 T148075_1 - 0.00033 20.4 5.3 0.00078 19.2 5.3 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 T148075_1 - 0.00055 19.6 5.0 0.00055 19.6 5.0 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 T148075_1 - 0.0036 17.0 1.5 0.0036 17.0 1.5 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 T148075_1 - 0.044 13.8 4.3 0.11 12.5 4.3 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 T148075_1 - 2.7 7.8 6.5 6.2 6.6 6.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 BRCT_assoc PF12820.5 T148075_3 - 2.2e-81 271.3 1.3 2.2e-81 271.3 1.3 3.1 2 0 0 2 2 2 1 Serine-rich domain associated with BRCT BRCT PF00533.24 T148075_3 - 1.6e-18 66.7 0.0 8.3e-09 35.6 0.0 2.9 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 T148075_3 - 0.00091 19.5 0.0 0.44 10.9 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain SM-ATX PF14438.4 T129552_1 - 1.9e-19 69.5 0.0 3.2e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain LsmAD PF06741.11 T129552_1 - 2e-17 63.4 1.9 3.2e-17 62.7 1.9 1.3 1 0 0 1 1 1 1 LsmAD domain PAM2 PF07145.13 T129552_1 - 1.6e-05 24.2 1.0 5.4e-05 22.5 1.0 2.0 1 0 0 1 1 1 1 Ataxin-2 C-terminal region LSM14 PF12701.5 T129552_1 - 0.06 13.3 0.0 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Scd6-like Sm domain Aph-1 PF06105.10 T020444_2 - 2e-92 308.6 14.0 2.6e-92 308.3 14.0 1.1 1 0 0 1 1 1 1 Aph-1 protein Peptidase_M3_N PF08439.8 T020444_2 - 0.14 12.3 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Oligopeptidase F Guanylate_kin PF00625.19 T258500_3 - 3.7e-66 222.1 1.5 5.7e-66 221.5 1.5 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 T258500_3 - 2.1e-61 204.1 8.7 1.1e-19 70.5 0.3 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) MAGUK_N_PEST PF10608.7 T258500_3 - 1.2e-39 135.3 10.2 6e-37 126.6 10.2 2.6 1 1 0 1 1 1 1 Polyubiquitination (PEST) N-terminal domain of MAGUK L27_1 PF09058.8 T258500_3 - 2.6e-29 101.0 4.3 5.5e-29 99.9 4.3 1.6 1 0 0 1 1 1 1 L27_1 PDZ_assoc PF10600.7 T258500_3 - 5.9e-24 84.6 4.2 1.6e-23 83.2 4.2 1.8 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 T258500_3 - 1.4e-15 57.2 0.9 0.00042 20.4 0.1 3.5 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.15 T258500_3 - 6.5e-08 32.0 0.0 1.4e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T258500_3 - 8.4e-08 31.6 0.1 1.8e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T258500_3 - 0.043 13.6 0.0 0.093 12.5 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain ABC_membrane PF00664.21 T327873_1 - 1.1e-137 458.1 20.8 3e-91 305.7 10.4 3.0 2 1 1 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.25 T327873_1 - 1.5e-75 252.1 0.8 8.1e-38 129.9 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 T327873_1 - 2.7e-17 62.8 2.8 5.7e-07 29.1 0.1 3.9 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.7 T327873_1 - 3e-10 39.4 0.7 0.00017 20.4 0.0 2.9 3 0 0 3 3 3 2 Predicted ATPase of the ABC class Zeta_toxin PF06414.10 T327873_1 - 1.7e-08 33.9 0.1 0.00026 20.2 0.0 3.2 3 0 0 3 3 3 2 Zeta toxin AAA_22 PF13401.4 T327873_1 - 3.9e-08 33.5 0.8 0.0081 16.3 0.1 3.2 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.4 T327873_1 - 3.9e-08 33.7 3.4 0.004 17.4 0.1 3.3 2 2 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.14 T327873_1 - 7.5e-08 32.3 0.1 0.013 15.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 G-alpha PF00503.18 T327873_1 - 3.3e-07 29.7 0.4 0.0024 16.9 0.1 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_29 PF13555.4 T327873_1 - 1.2e-06 28.0 0.6 0.029 14.0 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA PF00004.27 T327873_1 - 1.2e-06 28.8 4.3 0.026 14.8 0.1 4.3 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.13 T327873_1 - 2e-06 26.9 0.1 0.0074 15.1 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_15 PF13175.4 T327873_1 - 5.2e-06 26.2 0.2 0.043 13.3 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.4 T327873_1 - 2.2e-05 24.1 1.9 0.13 11.9 0.1 3.2 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.12 T327873_1 - 2.6e-05 24.1 0.3 0.46 10.3 0.1 3.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) DUF87 PF01935.15 T327873_1 - 3.2e-05 24.0 0.6 0.37 10.7 0.1 2.9 3 0 0 3 3 3 2 Domain of unknown function DUF87 AAA_14 PF13173.4 T327873_1 - 4.6e-05 23.3 0.1 0.018 14.9 0.0 3.6 3 1 0 3 3 3 1 AAA domain AAA_21 PF13304.4 T327873_1 - 0.0002 21.1 0.1 3.5 7.2 0.0 4.1 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.4 T327873_1 - 0.00021 21.3 5.0 0.44 10.7 0.4 3.8 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.15 T327873_1 - 0.00027 20.6 0.9 11 5.7 0.0 4.2 4 0 0 4 4 4 0 IstB-like ATP binding protein APS_kinase PF01583.18 T327873_1 - 0.00031 20.5 0.5 0.8 9.4 0.0 2.8 3 0 0 3 3 2 2 Adenylylsulphate kinase PRK PF00485.16 T327873_1 - 0.00058 19.5 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family DUF815 PF05673.11 T327873_1 - 0.00076 18.6 0.1 0.26 10.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.20 T327873_1 - 0.0011 19.2 0.0 4.1 7.7 0.0 3.4 3 0 0 3 3 3 1 RNA helicase ATP-synt_ab PF00006.23 T327873_1 - 0.0012 18.4 0.1 1.9 8.0 0.0 2.5 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.4 T327873_1 - 0.0017 18.0 0.0 0.53 9.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.4 T327873_1 - 0.0018 18.4 0.5 4.2 7.5 0.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.4 T327873_1 - 0.0049 16.9 0.0 2.8 8.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.4 T327873_1 - 0.0069 16.8 0.0 5.8 7.3 0.0 3.1 3 0 0 3 3 2 0 AAA domain tRNA_lig_kinase PF08303.9 T327873_1 - 0.0083 16.1 0.0 5.8 6.8 0.0 2.6 2 0 0 2 2 2 0 tRNA ligase kinase domain NACHT PF05729.10 T327873_1 - 0.011 15.5 0.0 3.8 7.3 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.4 T327873_1 - 0.041 13.3 1.5 6.8 6.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain ArgK PF03308.14 T327873_1 - 0.045 12.6 0.0 8.3 5.2 0.0 2.4 2 0 0 2 2 2 0 ArgK protein NB-ARC PF00931.20 T327873_1 - 0.057 12.3 1.8 6.2 5.6 0.1 2.6 3 0 0 3 3 2 0 NB-ARC domain AAA_23 PF13476.4 T327873_1 - 0.099 13.0 0.4 17 5.7 0.0 3.0 3 0 0 3 3 2 0 AAA domain PduV-EutP PF10662.7 T327873_1 - 0.11 12.1 0.8 25 4.5 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Choline_kinase PF01633.18 T236570_1 - 1.3e-65 220.9 0.0 1.8e-65 220.4 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase CPT_N PF16484.3 T236570_1 - 4.1e-26 90.6 0.1 7.3e-26 89.8 0.1 1.4 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus APH PF01636.21 T236570_1 - 1.6e-09 37.9 0.0 1.6e-09 37.9 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.18 T236570_1 - 0.0015 17.8 0.0 0.0028 16.9 0.0 1.3 1 1 0 1 1 1 1 Ecdysteroid kinase Carn_acyltransf PF00755.18 T236570_2 - 3e-193 643.5 0.0 3.6e-193 643.2 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase MOR2-PAG1_N PF14222.4 T264467_3 - 1.3e-172 575.5 5.2 2.1e-172 574.8 5.2 1.4 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.4 T264467_3 - 1.4e-74 251.0 6.6 1.4e-74 251.0 6.6 3.2 4 0 0 4 4 4 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.4 T264467_3 - 8.9e-39 132.9 12.1 6.2e-16 57.2 0.2 6.2 6 0 0 6 6 6 6 Cell morphogenesis central region RtcB PF01139.15 T232558_1 - 2.7e-145 484.6 0.2 3.2e-145 484.3 0.2 1.1 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB IL12p40_C PF10420.7 T292216_1 - 3.6e-07 30.4 0.1 7.7e-07 29.4 0.1 1.5 1 0 0 1 1 1 1 Cytokine interleukin-12p40 C-terminus fn3 PF00041.19 T292216_3 - 0.0023 18.1 0.4 0.0044 17.2 0.4 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Arm PF00514.21 T251212_2 - 5.3e-17 61.1 16.7 0.00041 20.1 0.2 10.6 11 0 0 11 11 11 4 Armadillo/beta-catenin-like repeat HEAT PF02985.20 T251212_2 - 4.4e-07 29.5 8.9 0.23 11.7 0.1 6.5 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.4 T251212_2 - 3.5e-06 27.2 1.5 0.012 16.0 0.1 4.9 6 0 0 6 6 6 1 HEAT-like repeat V-ATPase_H_C PF11698.6 T251212_2 - 0.0003 20.8 3.0 1.3 9.0 0.0 4.7 3 2 2 5 5 5 1 V-ATPase subunit H Uso1_p115_head PF04869.12 T251212_2 - 0.02 14.0 0.8 4.7 6.1 0.1 3.2 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, head region ParcG PF10274.7 T251212_2 - 0.16 11.9 2.9 0.9 9.5 0.3 2.9 3 0 0 3 3 3 0 Parkin co-regulated protein DUF383 PF04063.12 T251212_2 - 0.2 11.2 3.6 0.8 9.3 0.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF383) UNC45-central PF11701.6 T251212_2 - 0.23 11.3 8.6 8 6.3 0.2 3.8 2 1 2 4 4 4 0 Myosin-binding striated muscle assembly central IFRD PF05004.11 T251212_2 - 1.3 8.0 10.9 0.74 8.7 0.4 3.8 1 1 3 4 4 4 0 Interferon-related developmental regulator (IFRD) Kinesin PF00225.21 T289713_3 - 3.9e-105 351.3 0.0 3.9e-105 351.3 0.0 1.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 T289713_3 - 6.7e-15 55.2 0.0 9.7e-13 48.2 0.0 2.8 2 0 0 2 2 2 1 Microtubule binding Med9 PF07544.11 T289713_3 - 0.019 14.9 0.6 0.019 14.9 0.6 4.6 3 1 1 5 5 5 0 RNA polymerase II transcription mediator complex subunit 9 PhoU PF01895.17 T289713_3 - 2.4 8.5 7.4 0.19 12.1 1.8 2.1 2 0 0 2 2 2 0 PhoU domain DUF1664 PF07889.10 T289713_3 - 7.1 6.5 18.7 0.29 11.0 0.4 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) PBP_GOBP PF01395.20 T289713_3 - 9.4 6.3 11.0 6.4 6.9 0.4 3.2 3 0 0 3 3 3 0 PBP/GOBP family zf-C2H2_4 PF13894.4 T312978_2 - 4.6e-11 42.4 60.5 0.0078 16.8 0.4 8.7 8 0 0 8 8 8 6 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T312978_2 - 6.9e-11 42.0 52.7 0.00011 22.3 3.7 9.0 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2 PF00096.24 T312978_2 - 1.3e-09 37.8 68.9 4.5e-05 23.5 0.5 7.7 9 0 0 9 9 9 6 Zinc finger, C2H2 type zf-C2H2_11 PF16622.3 T312978_2 - 0.03 14.0 22.3 2.2 8.0 2.0 6.1 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-met PF12874.5 T312978_2 - 0.054 13.8 23.1 0.033 14.5 4.6 5.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 T312978_2 - 0.19 12.0 28.4 0.74 10.1 4.5 6.9 6 1 1 7 7 7 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.3 T312978_2 - 6.8 6.9 21.8 2.4 8.4 5.0 3.3 1 1 2 3 3 3 0 C2H2-type zinc ribbon Diphthamide_syn PF01866.15 T139493_2 - 2e-118 395.0 0.0 2.5e-118 394.7 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein FSH1 PF03959.11 T139493_3 - 5.9e-53 179.5 0.0 7.5e-53 179.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.14 T139493_3 - 5.4e-05 23.0 0.1 8.3e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Pyrophosphatase PF00719.17 T269076_3 - 8.8e-58 194.5 0.3 1.1e-57 194.1 0.3 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase TRAPP PF04051.14 T103251_3 - 5.8e-43 146.0 0.3 8.5e-43 145.4 0.3 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Cortexin PF11057.6 T288540_2 - 2.9e-39 132.6 0.1 7.1e-39 131.4 0.1 1.7 1 0 0 1 1 1 1 Cortexin of kidney Trypsin PF00089.24 T265745_1 - 9e-72 241.3 0.4 1.1e-71 241.0 0.4 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 T265745_1 - 4.4e-07 30.8 0.0 6.2e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 T265745_1 - 5.8e-06 26.5 0.0 9.4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SEA PF01390.18 T265745_2 - 4.2e-13 49.4 1.3 6.9e-13 48.7 1.3 1.3 1 0 0 1 1 1 1 SEA domain SEA PF01390.18 T265745_3 - 8.8e-05 22.6 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 SEA domain TACC PF05010.12 T342437_1 - 6.3e-80 267.6 34.4 8.4e-80 267.2 34.4 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) Bul1_C PF04426.10 T342437_1 - 7.8 5.7 10.8 13 5.0 10.8 1.2 1 0 0 1 1 1 0 Bul1 C terminus PI3K_P85_iSH2 PF16454.3 T342437_1 - 10 5.6 28.2 45 3.4 28.2 1.8 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain RCC1 PF00415.16 T122209_1 - 1e-19 70.8 11.4 1.3e-11 44.7 0.8 4.9 4 1 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 T122209_1 - 1.5e-17 62.8 13.4 6.5e-06 25.7 2.0 4.5 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.16 T122209_3 - 0.0008 19.8 0.0 0.0021 18.5 0.0 1.7 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat DUF1751 PF08551.8 T242960_1 - 1.4e-27 96.0 4.0 2.4e-27 95.2 4.0 1.4 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) VGCC_alpha2 PF08473.9 T242960_3 - 8.4e-212 703.5 0.1 1.1e-211 703.1 0.1 1.1 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.9 T242960_3 - 3.7e-40 137.1 0.4 7e-40 136.2 0.4 1.5 1 0 0 1 1 1 1 VWA N-terminal VWA PF00092.26 T242960_3 - 9.4e-19 68.2 0.1 1.4e-18 67.6 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 T242960_3 - 2.6e-13 50.0 0.0 4.1e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.16 T242960_3 - 1.8e-10 41.0 2.1 8.2e-10 38.8 0.3 2.4 2 0 0 2 2 2 1 Cache domain VWA_2 PF13519.4 T242960_3 - 3.6e-10 40.3 0.2 6.6e-10 39.5 0.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Tubulin PF00091.23 T035165_2 - 3.7e-07 30.4 0.0 5.6e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin PF00091.23 T035165_3 - 1.6e-44 152.3 0.0 2.6e-44 151.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 T035165_3 - 2.5e-40 137.5 0.0 4.4e-40 136.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain RNase_H PF00075.22 T035165_3 - 1.4e-10 41.4 0.0 2.4e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 RNase H Tubulin_3 PF14881.4 T035165_3 - 0.033 13.8 0.0 0.058 12.9 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 T035165_3 - 0.17 10.9 0.0 0.29 10.1 0.0 1.3 1 0 0 1 1 1 0 Tubulin like 7tm_2 PF00002.22 T372059_2 - 3.9e-56 190.0 22.8 5.8e-56 189.4 22.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 T372059_2 - 9.7e-13 48.4 2.1 4.8e-12 46.2 2.1 2.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Glyco_hydro_15 PF00723.19 T372059_3 - 6.8e-195 647.9 0.0 8.3e-195 647.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 PI3_PI4_kinase PF00454.25 T262509_3 - 5.3e-64 216.3 0.0 8.1e-64 215.7 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Phostensin_N PF13916.4 T300564_1 - 2.5e-34 117.3 4.3 2.5e-34 117.3 4.3 3.0 2 1 1 3 3 3 2 PP1-regulatory protein, Phostensin N-terminal Phostensin PF13914.4 T300564_1 - 8.4e-33 113.8 0.2 1.8e-32 112.8 0.2 1.6 1 0 0 1 1 1 1 Phostensin PP1-binding and SH3-binding region NnrU PF07298.9 T300564_3 - 0.00017 21.0 4.2 0.00032 20.1 4.2 1.4 1 0 0 1 1 1 1 NnrU protein RabGAP-TBC PF00566.16 T046372_3 - 2.9e-44 151.2 1.9 7.1e-44 149.9 0.8 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DDHD PF02862.15 T382658_1 - 0.32 11.0 7.7 0.55 10.2 7.7 1.3 1 0 0 1 1 1 0 DDHD domain PH PF00169.27 T382658_2 - 2e-17 63.4 0.4 2e-17 63.4 0.4 2.2 2 0 0 2 2 2 1 PH domain KH_1 PF00013.27 T211668_3 - 9.3e-181 585.8 58.7 4e-15 55.2 0.8 16.1 15 1 0 15 15 15 14 KH domain SLS PF14611.4 T211668_3 - 9e-17 61.5 17.3 4.8e-05 23.1 0.3 8.3 4 2 3 8 8 8 6 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.15 T211668_3 - 4.8e-16 58.2 32.5 0.0082 15.8 0.2 12.0 11 1 1 12 12 12 7 KH domain KH_5 PF13184.4 T211668_3 - 1.5e-05 24.8 22.5 2.1 8.3 0.3 9.7 11 0 0 11 11 11 3 NusA-like KH domain BMC PF00936.17 T211668_3 - 0.012 15.4 0.1 1.5e+02 2.3 0.0 5.8 7 0 0 7 7 7 0 BMC domain DUF4530 PF15039.4 T211668_3 - 0.069 13.2 0.0 20 5.2 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4530) DUF2067 PF09840.7 T211668_3 - 1.4 8.4 9.6 0.36 10.3 0.2 4.1 5 0 0 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2067) DUF2096 PF09869.7 T211668_3 - 2.1 8.3 14.7 11 5.9 0.3 5.8 6 2 0 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2096) EMI PF07546.11 T231774_1 - 1.5e-14 54.4 10.2 3.4e-14 53.2 10.2 1.7 1 0 0 1 1 1 1 EMI domain Collagen PF01391.16 T231774_2 - 2.4e-20 71.9 135.4 3.6e-09 36.1 31.5 6.5 4 3 2 6 6 6 4 Collagen triple helix repeat (20 copies) MFS_1 PF07690.14 T299062_1 - 7.7e-43 146.6 43.3 4.9e-42 144.0 36.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily bZIP_1 PF00170.19 T186951_1 - 1.1e-07 31.8 20.3 2.5e-07 30.5 20.3 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 T186951_1 - 8.1e-05 22.5 19.6 0.0002 21.2 19.6 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 T186951_1 - 0.0012 19.2 15.0 0.0012 19.2 15.0 1.7 2 0 0 2 2 2 1 bZIP Maf transcription factor Cadherin PF00028.15 T160487_1 - 3.3e-84 277.3 1.5 3.1e-21 75.5 0.0 5.6 5 0 0 5 5 5 5 Cadherin domain Cadherin_pro PF08758.9 T160487_1 - 3.9e-21 74.9 0.0 5.2e-19 68.1 0.0 2.7 2 0 0 2 2 2 1 Cadherin prodomain like Cadherin_C PF01049.15 T160487_1 - 7e-06 26.2 0.0 1.3e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.10 T160487_1 - 2.2e-05 24.0 0.0 0.6 9.8 0.0 3.4 3 0 0 3 3 3 2 Cadherin-like Cadherin_3 PF16184.3 T160487_1 - 0.058 13.3 2.9 1 9.2 0.6 2.9 3 0 0 3 3 3 0 Cadherin-like C2 PF00168.28 T237591_2 - 1.9e-27 95.5 0.3 4e-13 49.4 0.1 2.2 2 0 0 2 2 2 2 C2 domain VCBS PF13517.4 T237591_2 - 0.032 14.7 0.4 0.074 13.5 0.4 1.6 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Copine PF07002.14 T237591_3 - 1.6e-86 289.1 0.0 2e-86 288.8 0.0 1.1 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.7 T237591_3 - 8.9e-06 25.8 0.0 1.4e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus V-set PF07686.15 T156901_3 - 2.6e-14 53.2 0.2 9.2e-13 48.2 0.1 2.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T156901_3 - 1.3e-08 35.2 0.4 5.8e-05 23.5 0.3 3.1 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 T156901_3 - 0.00014 22.0 0.4 0.00055 20.1 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 T156901_3 - 0.00026 20.9 0.2 0.005 16.7 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 T156901_3 - 0.00067 19.6 0.1 0.0036 17.3 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin domain T-box PF00907.20 T086973_1 - 1.1e-80 270.1 0.2 1.6e-80 269.6 0.2 1.2 1 0 0 1 1 1 1 T-box TBX PF12598.6 T086973_1 - 9.5e-19 67.9 8.6 4.3e-18 65.8 8.6 2.3 1 0 0 1 1 1 1 T-box transcription factor I-set PF07679.14 T274302_2 - 6.7e-15 54.8 0.0 1.1e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T274302_2 - 2.7e-13 50.2 0.0 5.9e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T274302_2 - 9e-09 35.3 0.1 1.9e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T274302_2 - 4.8e-08 33.1 0.0 9.7e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 T274302_2 - 0.00026 21.0 0.0 0.00061 19.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain W2 PF02020.16 T255970_1 - 1.7e-18 66.4 4.3 2.6e-18 65.8 4.3 1.3 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.22 T255970_2 - 2.7e-09 36.3 7.4 0.00012 21.6 4.5 4.0 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.3 T255970_2 - 0.00026 19.1 0.2 0.00038 18.6 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.4 T255970_2 - 0.05 13.2 5.8 0.23 11.1 4.3 2.6 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.10 T255970_2 - 0.068 12.1 0.1 0.11 11.4 0.1 1.3 1 0 0 1 1 1 0 L-fucokinase zf-TRAF PF02176.16 T140576_1 - 0.0044 17.6 6.7 0.0044 17.6 6.7 3.9 1 1 2 3 3 3 2 TRAF-type zinc finger DUF1725 PF08333.9 T140576_2 - 3.2e-05 23.3 0.9 7.2e-05 22.2 0.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T140576_2 - 4.7e-05 22.9 0.0 8.4e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) F-box-like PF12937.5 T140576_3 - 6.9e-07 28.9 3.3 1.8e-06 27.6 3.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T140576_3 - 0.011 15.5 1.8 0.025 14.3 1.8 1.6 1 0 0 1 1 1 0 F-box domain OTU PF02338.17 T378854_1 - 7.8e-07 29.5 0.0 1.4e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Glyco_tran_28_C PF04101.14 T378854_2 - 6.4e-27 94.4 0.0 1.1e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain LLC1 PF14945.4 T378854_2 - 0.17 12.3 0.2 2.2 8.8 0.0 2.2 2 0 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Mito_carr PF00153.25 T275712_2 - 5.7e-66 218.4 3.7 4.7e-24 84.0 0.1 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein Ubiquitin_2 PF14560.4 T174222_1 - 2.6e-26 91.8 0.0 5.5e-26 90.7 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin-like domain CAP_GLY PF01302.23 T174222_1 - 3.4e-23 81.3 0.6 6e-23 80.5 0.6 1.4 1 0 0 1 1 1 1 CAP-Gly domain zf-H2C2_2 PF13465.4 T174222_1 - 1.1e-08 35.1 24.4 1.7e-08 34.4 0.3 5.4 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.24 T174222_1 - 1.1e-05 25.5 39.6 0.0074 16.6 0.8 5.8 5 0 0 5 5 5 4 Zinc finger, C2H2 type FYVE PF01363.19 T174222_1 - 0.1 12.6 17.5 0.25 11.4 3.3 2.8 1 1 1 2 2 2 0 FYVE zinc finger WD40 PF00400.30 T174222_2 - 3.1e-29 100.5 22.7 0.01 16.6 0.0 13.3 12 0 0 12 12 12 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T174222_2 - 2.6e-13 49.9 1.1 0.00017 21.7 0.0 6.0 4 1 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 T174222_2 - 0.015 15.1 0.2 0.5 10.1 0.0 2.3 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF5046 PF16465.3 T174222_2 - 0.024 14.0 0.6 0.15 11.4 0.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5046) C1-set PF07654.13 T212602_1 - 9.1e-25 86.8 4.8 1.7e-12 47.5 1.3 3.2 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Ig_3 PF13927.4 T212602_1 - 6.6e-21 74.6 6.9 1e-07 32.3 0.0 4.6 3 1 1 4 4 4 4 Immunoglobulin domain C2-set_2 PF08205.10 T212602_1 - 1.7e-18 66.3 12.6 1.2e-08 34.8 0.7 4.1 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.15 T212602_1 - 2.7e-16 59.6 0.1 1.3e-15 57.4 0.0 2.2 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.23 T212602_1 - 3e-13 49.6 10.2 3.9e-07 30.0 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.4 T212602_1 - 3.9e-13 49.4 3.0 0.0036 17.5 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T212602_1 - 4.2e-10 39.4 1.1 0.0006 19.7 0.0 4.1 3 1 1 4 4 4 3 Immunoglobulin I-set domain SIT PF15330.4 T212602_1 - 0.0026 18.0 0.2 0.0075 16.5 0.2 1.8 1 1 1 2 2 2 1 SHP2-interacting transmembrane adaptor protein, SIT DUF4448 PF14610.4 T212602_1 - 0.014 15.0 0.1 0.059 13.0 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4448) DUF912 PF06024.10 T212602_1 - 0.1 12.8 0.0 0.93 9.7 0.0 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Eryth_link_C PF16915.3 T212602_1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Annelid erythrocruorin linker subunit C-terminus DUF4577 PF15145.4 T212602_1 - 0.16 11.8 0.0 0.28 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) TMEM154 PF15102.4 T212602_1 - 8.2 6.2 8.1 0.71 9.6 0.0 2.2 2 0 0 2 2 2 0 TMEM154 protein family Ion_trans PF00520.29 T202403_2 - 3e-56 190.3 20.2 4.5e-56 189.7 20.2 1.3 1 0 0 1 1 1 1 Ion transport protein GPHH PF16905.3 T202403_2 - 1.2e-05 24.9 0.0 2.5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.25 T202403_2 - 0.0035 16.9 0.6 0.013 15.1 0.6 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif Ion_trans PF00520.29 T202403_3 - 2.6e-148 491.7 57.9 6.5e-65 218.6 20.0 3.5 3 0 0 3 3 3 3 Ion transport protein Na_trans_cytopl PF11933.6 T202403_3 - 8.9e-71 238.0 10.3 8.9e-71 238.0 10.3 1.6 2 0 0 2 2 2 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.11 T202403_3 - 2.1e-54 184.5 2.4 2.1e-54 184.5 2.4 2.2 2 0 0 2 2 2 1 Sodium ion transport-associated Tissue_fac PF01108.15 T005619_1 - 8.1e-27 93.0 0.0 2.5e-26 91.5 0.0 1.8 1 0 0 1 1 1 1 Tissue factor CLN3 PF02487.15 T005619_1 - 2.7 6.8 7.5 4.2 6.2 7.5 1.2 1 0 0 1 1 1 0 CLN3 protein Mtc1 PF10310.7 T005619_2 - 4.9 5.9 24.3 10 4.8 24.3 1.4 1 0 0 1 1 1 0 Maintenance of telomere capping protein 1 Presenilin PF01080.15 T005619_3 - 2.9 6.4 24.3 4.5 5.8 24.3 1.1 1 0 0 1 1 1 0 Presenilin HGWP PF03578.13 T152124_1 - 0.02 14.4 3.8 0.081 12.5 3.8 2.1 1 0 0 1 1 1 0 HGWP repeat Pkinase PF00069.23 T152124_3 - 5.7e-35 120.8 0.0 7.3e-35 120.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T152124_3 - 1.3e-22 80.2 0.0 3.1e-21 75.7 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Neur_chan_LBD PF02931.21 T371657_2 - 8.5e-42 142.9 0.2 1.3e-41 142.3 0.2 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 T371657_2 - 1.4e-37 129.9 5.0 9.3e-33 114.1 1.7 2.3 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region RRM_1 PF00076.20 T166806_1 - 6.2e-13 48.2 0.0 1.2e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.25 T166806_1 - 2.4e-09 36.6 0.5 5.3e-09 35.5 0.5 1.6 1 0 0 1 1 1 1 SAP domain RRM_5 PF13893.4 T166806_1 - 1.8e-06 27.5 0.0 3.3e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-H2C2_2 PF13465.4 T302313_1 - 9.3e-27 92.1 29.9 1e-08 35.1 1.4 5.5 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 T302313_1 - 6.2e-19 67.2 29.0 4.4e-05 23.6 0.4 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T302313_1 - 3.5e-13 49.0 26.2 0.0035 17.9 0.4 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T302313_1 - 9.3e-05 22.5 1.0 0.56 10.5 0.1 3.8 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.16 T302313_1 - 0.023 15.3 1.0 0.023 15.3 1.0 2.5 3 0 0 3 3 3 0 TRAF-type zinc finger CopK PF11525.6 T302313_1 - 0.051 13.1 0.1 37 3.9 0.0 3.5 3 1 1 4 4 4 0 Copper resistance protein K zf-C2H2_aberr PF17017.3 T302313_1 - 0.19 11.7 8.9 3.8 7.5 0.2 3.9 2 1 2 4 4 4 0 Aberrant zinc-finger zf-C2H2_6 PF13912.4 T302313_1 - 3.3 7.6 9.3 0.69 9.8 0.2 3.2 4 0 0 4 4 4 0 C2H2-type zinc finger PH PF00169.27 T302313_2 - 1.8e-18 66.9 0.2 3.3e-18 66.0 0.2 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 T302313_2 - 0.00051 20.1 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 T302313_2 - 0.0011 19.2 1.8 0.017 15.4 1.8 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.8 T302313_2 - 0.0035 17.5 0.0 0.0079 16.4 0.0 1.6 1 0 0 1 1 1 1 Plant pleckstrin homology-like region EF-hand_6 PF13405.4 T302313_2 - 0.11 12.4 0.0 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain MVL PF12151.6 T302313_2 - 6.2 6.6 9.3 1.2 8.9 0.3 3.2 3 0 0 3 3 3 0 Mannan-binding protein zf-C2H2 PF00096.24 T302313_3 - 0.0023 18.2 1.6 0.0023 18.2 1.6 4.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T302313_3 - 0.17 12.3 13.3 2.9 8.4 0.3 3.5 2 0 0 2 2 2 0 Zinc-finger double domain Ldl_recept_a PF00057.16 T335462_1 - 2.3e-31 107.6 123.9 2e-11 43.8 9.7 10.6 9 1 1 10 10 10 6 Low-density lipoprotein receptor domain class A TIL PF01826.15 T335462_1 - 9.2e-21 73.7 85.5 1.4e-09 37.9 14.6 15.1 13 2 2 15 15 15 5 Trypsin Inhibitor like cysteine rich domain C8 PF08742.9 T335462_1 - 3.4e-16 59.3 4.4 3.4e-16 59.3 4.4 3.7 2 0 0 2 2 2 1 C8 domain TSP_1 PF00090.17 T335462_1 - 1.8e-15 56.8 62.8 2e-08 34.2 7.5 8.2 5 1 1 6 6 6 4 Thrombospondin type 1 domain VWC PF00093.16 T335462_1 - 7.3e-07 29.3 22.2 2.2e-05 24.5 12.9 11.7 11 1 2 13 13 13 3 von Willebrand factor type C domain Pacifastin_I PF05375.11 T335462_1 - 0.00014 21.4 4.9 0.00014 21.4 4.9 7.1 7 0 0 7 7 7 4 Pacifastin inhibitor (LCMII) TSP_1 PF00090.17 T335462_2 - 3.4e-44 148.7 105.2 1.6e-09 37.7 7.2 8.1 6 0 0 6 6 6 6 Thrombospondin type 1 domain VWD PF00094.23 T335462_2 - 3.6e-42 144.2 0.0 1.8e-20 73.7 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type D domain TIL PF01826.15 T335462_2 - 1.7e-25 88.9 207.6 7e-08 32.5 16.8 13.6 11 2 1 12 12 12 7 Trypsin Inhibitor like cysteine rich domain TSP_1 PF00090.17 T335462_3 - 1.2e-68 227.0 234.3 3.2e-11 43.1 8.8 16.5 15 0 0 15 15 15 12 Thrombospondin type 1 domain C8 PF08742.9 T335462_3 - 1.6e-33 114.8 26.7 2.3e-16 59.8 7.6 4.1 2 0 0 2 2 2 2 C8 domain VWD PF00094.23 T335462_3 - 1.3e-22 80.7 0.0 1.2e-14 54.7 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type D domain Ldl_recept_a PF00057.16 T335462_3 - 1.7e-19 69.6 94.5 2.3e-08 34.0 9.3 7.8 8 0 0 8 8 8 5 Low-density lipoprotein receptor domain class A F5_F8_type_C PF00754.23 T335462_3 - 2.2e-18 66.5 0.0 3.7e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain TIL PF01826.15 T335462_3 - 2.4e-16 59.5 78.4 1.4e-07 31.5 16.7 17.1 17 3 1 18 18 18 4 Trypsin Inhibitor like cysteine rich domain Pacifastin_I PF05375.11 T335462_3 - 4.2e-07 29.4 20.1 3.2e-06 26.6 4.3 6.0 5 0 0 5 5 5 3 Pacifastin inhibitor (LCMII) VWC PF00093.16 T335462_3 - 0.0013 18.9 13.4 0.0013 18.9 13.4 15.6 15 3 2 17 17 17 3 von Willebrand factor type C domain IMD PF08397.9 T233531_1 - 1.4e-89 299.1 6.4 1.8e-89 298.7 6.4 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain MFS_1 PF07690.14 T233531_1 - 5e-16 58.4 11.4 7.4e-16 57.9 11.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily SH3_9 PF14604.4 T233531_1 - 4.4e-09 35.9 0.0 1.1e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.3 T233531_1 - 0.00025 20.7 7.3 0.00036 20.1 7.3 1.1 1 0 0 1 1 1 1 BAR domain of APPL family SH3_2 PF07653.15 T233531_1 - 0.00029 20.3 0.0 0.00073 19.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T233531_1 - 0.012 15.1 0.0 0.023 14.1 0.0 1.5 1 0 0 1 1 1 0 SH3 domain Ank_2 PF12796.5 T233531_2 - 1.6e-31 108.6 3.8 2.9e-09 37.2 0.2 4.3 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T233531_2 - 2e-30 104.6 1.3 9.9e-07 29.1 0.1 6.9 6 1 1 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.28 T233531_2 - 3.6e-27 93.4 5.6 8.7e-05 22.7 0.0 6.9 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.4 T233531_2 - 9.9e-26 89.3 6.4 1.3e-10 41.2 1.1 5.8 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.4 T233531_2 - 5.6e-22 75.3 4.3 0.00095 19.3 0.0 6.8 6 0 0 6 6 6 4 Ankyrin repeat Patatin PF01734.20 T233531_2 - 2e-13 50.8 0.8 1e-12 48.5 0.8 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase MFS_1 PF07690.14 T233531_2 - 0.02 13.7 2.9 0.04 12.7 2.9 1.4 1 0 0 1 1 1 0 Major Facilitator Superfamily MBOAT PF03062.17 T241001_1 - 1.8e-11 43.9 11.1 3.6e-11 42.9 9.9 1.9 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family CDP-OH_P_tran_2 PF08009.9 T241001_1 - 0.84 9.5 9.5 0.12 12.2 2.1 3.5 3 1 1 4 4 4 0 CDP-alcohol phosphatidyltransferase 2 KRAB PF01352.25 T300217_1 - 7.4e-23 79.8 0.6 1.5e-22 78.9 0.6 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2 PF00096.24 T300217_3 - 6.1e-22 76.7 72.1 5e-06 26.6 2.4 8.3 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T300217_3 - 3e-19 67.9 64.0 0.0016 19.0 2.0 7.9 7 0 0 7 7 7 6 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T300217_3 - 4.5e-14 52.0 56.0 1.2e-06 28.6 2.7 8.6 8 0 0 8 8 8 4 Zinc-finger double domain zf-C2H2_jaz PF12171.6 T300217_3 - 0.0012 19.0 38.1 0.042 14.0 0.2 7.3 7 0 0 7 7 7 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 T300217_3 - 0.037 14.2 0.7 0.037 14.2 0.7 3.9 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding BolA PF01722.16 T300217_3 - 1.1 9.4 4.4 9.1 6.5 0.1 3.7 3 1 0 3 3 3 0 BolA-like protein Hep_59 PF07052.9 T220292_3 - 0.14 12.8 0.1 0.14 12.8 0.1 3.2 3 0 0 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 GGN PF15685.3 T174876_2 - 5.3e-270 897.9 124.9 5.3e-270 897.9 124.9 1.4 2 0 0 2 2 2 1 Gametogenetin GGN PF15685.3 T174876_3 - 2.6e-40 139.0 26.1 2.6e-40 139.0 26.1 3.2 2 1 0 3 3 3 1 Gametogenetin Pkinase PF00069.23 T071318_3 - 1.6e-54 184.9 0.0 2.3e-54 184.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T071318_3 - 1.7e-42 145.4 0.1 2.5e-42 144.8 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.6 T071318_3 - 2.1e-18 65.8 5.5 4e-17 61.7 1.3 2.5 2 0 0 2 2 2 2 Oxidative-stress-responsive kinase 1 C terminal SynMuv_product PF06047.9 T071318_3 - 0.89 9.6 3.4 1.8 8.6 3.4 1.4 1 0 0 1 1 1 0 Ras-induced vulval development antagonist CCDC-167 PF15188.4 T071318_3 - 8.2 6.7 9.7 64 3.9 0.2 3.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Pkinase PF00069.23 T195514_3 - 2.3e-61 207.3 0.0 3.7e-61 206.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.20 T195514_3 - 1.7e-57 195.0 0.0 2.4e-57 194.5 0.0 1.2 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 T195514_3 - 3.3e-44 151.0 0.0 5.1e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MOSC PF03473.15 T030841_1 - 1.4e-34 118.8 0.0 2.5e-34 118.0 0.0 1.4 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.14 T030841_1 - 2.7e-34 117.5 0.0 4.2e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC_N PF03476.14 T030841_2 - 1.3e-34 118.5 0.0 2e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.15 T030841_2 - 7.5e-30 103.5 0.0 1.1e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 MOSC domain DUF4175 PF13779.4 T030841_2 - 0.09 10.5 1.6 0.13 10.1 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CRAL_TRIO PF00650.18 T232113_1 - 7.6e-31 106.8 0.0 1e-25 90.2 0.0 2.2 2 0 0 2 2 2 2 CRAL/TRIO domain CRAL_TRIO_2 PF13716.4 T232113_1 - 4.1e-05 23.6 0.0 7.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.13 T232113_1 - 0.024 14.7 0.1 0.05 13.6 0.1 1.5 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain CARD PF00619.19 T066733_2 - 2.3e-24 85.1 0.2 3.3e-24 84.6 0.2 1.2 1 0 0 1 1 1 1 Caspase recruitment domain Peptidase_C14 PF00656.20 T066733_3 - 2.9e-50 171.4 0.0 4.9e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 Caspase domain CARD PF00619.19 T066733_3 - 6.7e-14 51.6 0.0 1.3e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Caspase recruitment domain PHD PF00628.27 T052281_1 - 1.7e-13 50.1 4.2 1.7e-13 50.1 4.2 3.0 3 0 0 3 3 3 1 PHD-finger zf-RING_2 PF13639.4 T052281_1 - 5.5e-09 36.0 17.2 3.7e-08 33.4 4.0 3.0 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4 PF00097.23 T052281_1 - 6.1e-07 29.1 4.0 6.1e-07 29.1 4.0 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T052281_1 - 1.6e-06 27.9 4.2 1.6e-06 27.9 4.2 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 T052281_1 - 1.7e-06 27.7 3.6 1.7e-06 27.7 3.6 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T052281_1 - 0.00033 20.3 4.7 0.00033 20.3 4.7 2.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 T052281_1 - 0.00055 20.0 4.4 0.00055 20.0 4.4 3.1 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 T052281_1 - 0.0037 17.1 3.0 0.0037 17.1 3.0 2.2 2 0 0 2 2 1 1 zinc-RING finger domain PHD_2 PF13831.4 T052281_1 - 0.04 13.3 0.5 0.12 11.8 0.5 1.9 1 0 0 1 1 1 0 PHD-finger zf-RING_11 PF17123.3 T052281_1 - 0.081 12.5 6.5 0.03 13.9 3.1 2.1 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_4 PF15227.4 T052281_1 - 1.2 9.2 16.2 0.12 12.4 9.0 2.7 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING IBR PF01485.19 T052281_1 - 2.4 8.3 9.3 0.075 13.1 2.4 2.1 2 0 0 2 2 1 0 IBR domain, a half RING-finger domain Prok-RING_4 PF14447.4 T052281_1 - 4.4 7.1 16.3 0.066 12.9 2.2 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 T052281_1 - 9.5 6.3 9.7 0.63 10.1 3.7 2.2 2 0 0 2 2 1 0 zinc RING finger of MSL2 SAM_1 PF00536.28 T254433_2 - 6.1e-15 55.3 0.0 9.7e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 T254433_2 - 0.064 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain DUF4539 PF15072.4 T148441_3 - 2.4e-30 104.3 0.0 4e-30 103.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) 2OG-FeII_Oxy_2 PF13532.4 T107876_2 - 5.1e-23 82.2 0.0 6.7e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF4476 PF14771.4 T093210_3 - 7.8e-22 77.3 0.6 1.2e-21 76.7 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) CUB PF00431.18 T329748_2 - 1.3e-59 199.2 0.0 8.2e-29 100.0 0.0 2.2 2 0 0 2 2 2 2 CUB domain NTR PF01759.19 T329748_2 - 4.3e-12 45.7 0.0 6.6e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module CUB_2 PF02408.18 T329748_2 - 7.4e-07 28.8 0.1 0.0031 17.1 0.0 2.4 2 0 0 2 2 2 2 CUB-like domain TFIID-18kDa PF02269.14 T016759_1 - 1e-36 124.7 0.4 1.4e-36 124.2 0.4 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit RVT_1 PF00078.25 T362867_1 - 7.4e-06 25.5 0.1 0.09 12.1 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) BAGE PF08180.9 T362867_1 - 0.12 12.4 0.4 0.22 11.5 0.4 1.5 1 0 0 1 1 1 0 B melanoma antigen family FBPase PF00316.18 T362867_3 - 3.5e-17 62.4 0.0 5.3e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain FHA PF00498.24 T300825_2 - 1.6e-10 41.0 0.0 2.5e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 FHA domain PHD PF00628.27 T300825_2 - 1.2e-06 28.1 12.0 2.3e-06 27.3 12.0 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.4 T300825_2 - 0.12 11.8 7.0 0.33 10.4 7.0 1.7 1 0 0 1 1 1 0 PHD-finger DHC_N2 PF08393.11 T054037_1 - 8.8e-42 143.5 0.1 8.8e-42 143.5 0.1 2.2 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 MT PF12777.5 T054037_1 - 1.1e-13 50.9 0.0 1.7e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.5 T054037_1 - 3.6e-09 36.2 0.0 7.8e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_16 PF13191.4 T054037_1 - 0.88 9.8 8.4 2.4 8.4 0.0 4.2 3 1 0 4 4 4 0 AAA ATPase domain DDHD PF02862.15 T054037_1 - 3.9 7.4 6.2 0.84 9.6 2.0 1.9 2 0 0 2 2 2 0 DDHD domain NPR3 PF03666.11 T054037_1 - 7.7 5.0 12.1 17 3.9 12.1 1.5 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CPSF100_C PF13299.4 T054037_1 - 9 6.3 9.6 0.15 12.1 2.0 1.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Dynein_heavy PF03028.13 T054037_2 - 7.5e-45 153.3 1.2 8.3e-45 153.1 0.2 1.5 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor AAA_6 PF12774.5 T054037_2 - 4.3e-11 42.9 0.0 4.5e-10 39.5 0.0 2.1 1 1 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_16 PF13191.4 T054037_2 - 1e-05 25.8 0.5 0.079 13.2 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.12 T054037_2 - 1.9e-05 24.5 0.1 0.035 14.0 0.0 3.0 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA PF00004.27 T054037_2 - 0.0044 17.3 0.0 2.8 8.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_9 PF12781.5 T054037_2 - 0.0066 15.5 0.2 0.1 11.6 0.5 2.4 3 0 0 3 3 3 1 ATP-binding dynein motor region D5 AAA_22 PF13401.4 T054037_2 - 0.017 15.2 0.2 0.58 10.3 0.0 3.2 4 0 0 4 4 4 0 AAA domain Sigma54_activ_2 PF14532.4 T054037_2 - 0.03 14.3 0.1 6.3 6.8 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain T2SSE PF00437.18 T054037_2 - 0.04 12.8 0.0 0.07 12.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.4 T054037_2 - 0.14 11.8 0.1 3.5 7.3 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.25 T054037_2 - 0.18 12.2 0.1 5.3 7.4 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Dynein_heavy PF03028.13 T054037_3 - 4.3e-43 147.4 0.0 5.6e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DUF4939 PF16297.3 T376671_1 - 3.7e-13 49.2 0.0 7.6e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC PF00098.21 T376671_1 - 5.1e-05 23.0 3.3 0.00055 19.8 0.6 2.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_2 PF13696.4 T376671_1 - 0.036 13.7 0.9 0.11 12.2 0.9 1.9 1 0 0 1 1 1 0 Zinc knuckle SSXT PF05030.10 T376671_1 - 0.087 12.3 0.5 0.18 11.3 0.5 1.5 1 0 0 1 1 1 0 SSXT protein (N-terminal region) Retrotrans_gag PF03732.15 T376671_1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Retrotransposon gag protein zf-CCHC_5 PF14787.4 T376671_1 - 0.19 11.4 0.8 0.38 10.4 0.8 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger gag-asp_proteas PF13975.4 T376671_3 - 0.048 14.1 0.0 0.077 13.4 0.0 1.2 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease S1 PF00575.21 T006965_3 - 3.6e-06 27.1 0.2 6.7e-06 26.2 0.2 1.3 1 0 0 1 1 1 1 S1 RNA binding domain SR-25 PF10500.7 T006965_3 - 0.062 12.8 26.2 0.11 12.0 26.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-CCHC PF00098.21 T006965_3 - 0.099 12.6 5.9 0.34 10.9 5.9 2.0 1 0 0 1 1 1 0 Zinc knuckle DUF3827 PF12877.5 T006965_3 - 2.9 6.0 11.4 4.2 5.5 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF3512 PF12024.6 T277307_3 - 5e-85 284.6 0.2 5e-85 284.6 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3512) Bromodomain PF00439.23 T277307_3 - 8.1e-24 83.4 0.0 1.1e-22 79.7 0.1 2.3 2 0 0 2 2 2 1 Bromodomain TFIIF_alpha PF05793.10 T277307_3 - 0.065 11.7 16.1 0.1 11.1 16.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SR-25 PF10500.7 T277307_3 - 1.8 8.0 20.9 0.058 12.9 14.7 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CENP-N PF05238.11 T277307_3 - 2.8 7.0 7.4 4.9 6.2 7.4 1.3 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Coilin_N PF15862.3 T277307_3 - 3.4 7.3 14.4 7.9 6.1 14.4 1.5 1 0 0 1 1 1 0 Coilin N-terminus MIP-T3 PF10243.7 T277307_3 - 4.5 5.7 18.4 7 5.1 18.4 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 NARP1 PF12569.6 T277307_3 - 6.9 5.3 13.7 11 4.6 13.7 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 U79_P34 PF03064.14 T277307_3 - 8.4 5.5 18.4 14 4.8 18.4 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 LRR19-TM PF15176.4 T356776_3 - 6.6e-41 138.5 0.1 1.3e-40 137.6 0.1 1.5 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain LRR_8 PF13855.4 T356776_3 - 3.3e-16 58.6 12.3 2e-15 56.1 3.5 2.9 1 1 1 2 2 2 2 Leucine rich repeat LRR_9 PF14580.4 T356776_3 - 0.0084 15.5 1.2 0.014 14.7 1.2 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 T356776_3 - 0.74 10.2 18.9 0.28 11.5 0.9 4.1 1 1 3 4 4 4 0 Leucine Rich repeats (2 copies) WH1 PF00568.21 T110137_1 - 1.3e-34 118.3 0.5 2e-34 117.7 0.5 1.2 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 T110137_1 - 2.1e-18 65.5 4.8 2.1e-18 65.5 4.8 1.5 2 0 0 2 2 2 1 VASP tetramerisation domain Ran_BP1 PF00638.16 T110137_1 - 0.015 15.4 0.0 0.028 14.6 0.0 1.3 1 0 0 1 1 1 0 RanBP1 domain IL5 PF02025.13 T288890_1 - 4.9e-60 200.6 0.5 7.7e-60 199.9 0.5 1.3 1 0 0 1 1 1 1 Interleukin 5 Chibby PF14645.4 T094099_1 - 1.1e-12 48.2 15.4 4e-11 43.2 0.3 3.2 2 1 1 3 3 3 2 Chibby family ZapB PF06005.10 T094099_1 - 0.6 10.5 32.6 0.14 12.4 6.9 3.3 3 0 0 3 3 3 0 Cell division protein ZapB Ferritin PF00210.22 T059997_3 - 8.7e-37 126.1 4.4 1.2e-36 125.7 4.4 1.2 1 0 0 1 1 1 1 Ferritin-like domain Pkinase PF00069.23 T175479_3 - 1.8e-76 256.8 0.0 2.4e-76 256.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T175479_3 - 1e-35 123.2 0.0 1.4e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Cyclin_N PF00134.21 T175479_3 - 1e-14 54.3 0.0 4.6e-14 52.2 0.0 2.0 1 1 0 1 1 1 1 Cyclin, N-terminal domain PH PF00169.27 T175479_3 - 1.6e-11 44.5 0.0 2.9e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.4 T175479_3 - 1.9e-08 33.8 0.0 3.8e-08 32.9 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.22 T175479_3 - 1.6e-07 31.8 0.8 3.2e-07 30.8 0.8 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Cyclin_C PF02984.17 T175479_3 - 0.01 15.8 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Cyclin, C-terminal domain YadA_head PF05658.12 T277213_1 - 0.11 12.8 14.9 0.67 10.3 1.4 3.5 3 0 0 3 3 3 0 Head domain of trimeric autotransporter adhesin DUF3512 PF12024.6 T277213_2 - 4.4e-84 281.5 0.2 4.4e-84 281.5 0.2 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3512) Bromodomain PF00439.23 T277213_2 - 2.2e-22 78.8 0.0 7.8e-22 77.0 0.1 1.8 2 0 0 2 2 2 1 Bromodomain zf-DHHC PF01529.18 T277213_2 - 3.5e-19 69.1 10.8 3.5e-19 69.1 10.8 4.6 4 0 0 4 4 4 2 DHHC palmitoyltransferase YadA_head PF05658.12 T277213_2 - 0.19 12.0 11.4 0.59 10.5 3.1 2.6 2 0 0 2 2 2 0 Head domain of trimeric autotransporter adhesin TFIIF_alpha PF05793.10 T277213_2 - 0.3 9.5 15.5 0.43 9.0 15.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SR-25 PF10500.7 T277213_2 - 0.38 10.2 15.7 0.86 9.0 15.7 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med19 PF10278.7 T277213_2 - 0.67 9.7 19.8 1.4 8.7 19.8 1.5 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 C2 PF00168.28 T377621_3 - 1.3e-40 137.7 0.0 4.1e-19 68.6 0.0 2.4 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 T377621_3 - 8.8e-22 77.4 9.6 2.3e-21 76.0 9.6 1.7 1 0 0 1 1 1 1 FYVE-type zinc finger AreA_N PF07573.9 T377621_3 - 0.021 15.3 0.3 0.044 14.3 0.3 1.4 1 0 0 1 1 1 0 Nitrogen regulatory protein AreA N terminus SAM_2 PF07647.15 T328328_1 - 2e-06 27.7 0.2 4.9e-06 26.4 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 T328328_1 - 3.3e-06 27.3 0.8 6.9e-06 26.3 0.8 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 T328328_1 - 0.002 17.9 0.3 0.0048 16.7 0.3 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Ish1 PF10281.7 T328328_1 - 0.19 11.9 1.8 0.55 10.5 1.8 1.9 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein SAM_1 PF00536.28 T328328_2 - 0.0018 18.5 0.6 0.02 15.2 0.2 2.5 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) OAD_gamma PF04277.11 T263833_1 - 4.5 7.8 4.4 8.7 6.9 4.4 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain RRM_1 PF00076.20 T263833_2 - 7.3e-37 124.9 0.1 5.5e-14 51.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T263833_2 - 2e-05 24.5 0.1 0.26 11.3 0.0 4.3 4 0 0 4 4 4 2 RNA recognition motif RRM_5 PF13893.4 T263833_2 - 0.00063 19.2 0.0 0.072 12.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Coilin_N PF15862.3 T263833_2 - 1.5 8.5 12.8 0.59 9.8 8.9 2.0 2 0 0 2 2 2 0 Coilin N-terminus fn3 PF00041.19 T042483_2 - 2e-06 27.9 0.1 4.3e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III domain fn3_4 PF16794.3 T042483_2 - 0.095 12.5 0.2 0.17 11.7 0.2 1.4 1 0 0 1 1 1 0 Fibronectin-III type domain Meiosis_expr PF15163.4 T037589_2 - 2.2e-37 127.4 9.4 3.3e-37 126.8 9.4 1.3 1 0 0 1 1 1 1 Meiosis-expressed zf-H2C2_2 PF13465.4 T135171_3 - 4.8e-85 276.4 98.9 1.6e-08 34.5 0.2 16.9 16 1 0 16 16 16 14 Zinc-finger double domain zf-C2H2 PF00096.24 T135171_3 - 1.2e-59 195.4 102.7 3.4e-06 27.1 1.3 14.7 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T135171_3 - 6e-33 110.5 96.3 0.0047 17.5 2.9 14.3 13 0 0 13 13 13 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T135171_3 - 1.8e-19 69.1 84.0 0.019 14.8 1.1 13.4 13 0 0 13 13 13 12 C2H2-type zinc finger KRAB PF01352.25 T135171_3 - 3.4e-15 55.3 0.1 6.7e-15 54.4 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 T135171_3 - 2e-13 50.1 53.0 0.13 12.5 0.1 12.5 12 0 0 12 12 12 8 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T135171_3 - 6.1e-07 29.3 65.3 0.026 14.5 3.6 9.6 5 3 4 10 10 10 8 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T135171_3 - 0.0017 18.9 45.3 0.14 12.8 1.1 7.3 2 1 6 8 8 8 3 zinc-ribbon family zf-C2H2_11 PF16622.3 T135171_3 - 0.0019 17.8 71.9 0.059 13.0 0.5 13.4 14 0 0 14 14 14 7 zinc-finger C2H2-type GATA PF00320.25 T135171_3 - 5 6.7 23.6 1.8 8.1 0.2 7.2 7 1 0 7 7 7 0 GATA zinc finger Laminin_EGF PF00053.22 T367959_1 - 6.3e-10 38.9 34.2 1.2e-07 31.6 13.4 4.5 4 1 1 5 5 5 2 Laminin EGF domain EGF_2 PF07974.11 T367959_1 - 0.0006 20.0 10.6 0.0006 20.0 10.6 5.8 6 0 0 6 6 6 1 EGF-like domain Laminin_N PF00055.15 T367959_2 - 3.7e-49 167.3 0.0 3.7e-49 167.3 0.0 2.4 3 0 0 3 3 3 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.22 T367959_2 - 3.1e-07 30.3 7.9 1.3e-06 28.3 7.9 2.1 1 0 0 1 1 1 1 Laminin EGF domain BNR PF02012.18 T367959_2 - 0.12 12.3 0.4 9.6 6.6 0.0 2.9 2 0 0 2 2 2 0 BNR/Asp-box repeat IGFL PF14653.4 T177529_1 - 2e-40 136.5 11.8 2e-40 136.5 11.8 2.1 2 0 0 2 2 2 1 Insulin growth factor-like family ubiquitin PF00240.21 T148502_2 - 5.4e-09 35.5 0.0 8.4e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Paf1 PF03985.11 T175194_3 - 1.7e-150 501.6 23.2 1.7e-150 501.6 23.2 2.1 1 1 1 2 2 2 1 Paf1 BUD22 PF09073.8 T175194_3 - 9.1 5.4 45.9 18 4.3 45.9 1.5 1 0 0 1 1 1 0 BUD22 PARP PF00644.18 T100336_1 - 1.3e-75 253.5 0.0 3.3e-75 252.1 0.0 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.12 T100336_1 - 1.5e-48 164.2 2.1 1.9e-48 163.9 0.7 1.9 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.13 T100336_1 - 9.6e-28 95.9 2.1 2.1e-27 94.9 2.1 1.6 1 0 0 1 1 1 1 WGR domain NPF PF16601.3 T238583_1 - 2.6e-78 262.7 21.6 3.6e-78 262.2 21.6 1.2 1 0 0 1 1 1 1 Rabosyn-5 repeating NPF sequence-motif Rbsn PF11464.6 T238583_1 - 7.5e-29 99.1 7.4 5.1e-16 58.0 1.3 2.4 2 0 0 2 2 2 2 Rabenosyn Rab binding domain FYVE PF01363.19 T238583_1 - 9.6e-17 60.8 6.6 3.3e-16 59.1 6.6 2.0 1 0 0 1 1 1 1 FYVE zinc finger L51_S25_CI-B8 PF05047.14 T238583_2 - 3.4e-09 36.4 0.2 6.1e-09 35.5 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Kringle PF00051.16 T242620_1 - 5.6e-43 145.0 13.0 7.2e-28 96.6 4.9 2.4 2 0 0 2 2 2 2 Kringle domain Trypsin PF00089.24 T242620_1 - 2.1e-42 145.3 0.1 3.2e-42 144.7 0.1 1.2 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 T242620_1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Kringle PF00051.16 T242620_2 - 1.6e-35 121.1 9.2 1.4e-25 89.3 2.0 2.6 2 0 0 2 2 2 2 Kringle domain PAN_1 PF00024.24 T242620_2 - 1.3e-12 47.4 0.0 2.8e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.4 T242620_2 - 0.12 12.2 2.3 0.15 11.9 0.3 2.3 2 0 0 2 2 2 0 PAN domain Kringle PF00051.16 T242620_3 - 2e-29 101.6 5.0 3.3e-29 100.9 5.0 1.4 1 0 0 1 1 1 1 Kringle domain TIR PF01582.18 T195603_2 - 7.8e-46 155.9 0.0 1.1e-45 155.4 0.0 1.2 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.4 T195603_2 - 7.5e-06 26.3 0.3 0.16 12.5 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 T195603_2 - 8.5e-06 25.7 0.6 0.26 11.4 0.0 3.0 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.4 T195603_2 - 1.8e-05 24.8 0.2 5.4e-05 23.3 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 T195603_2 - 8.5e-05 22.5 0.5 0.26 11.3 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.14 T195603_2 - 0.0018 18.2 0.1 0.16 11.9 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.4 T195603_3 - 3.6e-06 27.1 0.0 8.5e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T195603_3 - 0.00032 20.6 0.0 0.0006 19.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T195603_3 - 0.027 14.9 0.0 0.066 13.7 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain CDP-OH_P_transf PF01066.19 T085131_2 - 4.9e-17 62.3 0.1 2e-16 60.4 0.1 2.2 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase I-set PF07679.14 T085131_3 - 1.9e-90 297.0 0.4 5.9e-18 64.6 0.0 7.3 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.4 T085131_3 - 4.4e-59 196.9 0.1 1.1e-12 48.2 0.1 7.4 7 0 0 7 7 7 7 Immunoglobulin domain fn3 PF00041.19 T085131_3 - 1.1e-40 137.6 0.0 2.2e-13 50.2 0.0 3.7 3 0 0 3 3 3 3 Fibronectin type III domain Ig_2 PF13895.4 T085131_3 - 1.9e-29 101.7 0.1 1.3e-07 31.7 0.2 7.5 7 0 0 7 7 7 6 Immunoglobulin domain ig PF00047.23 T085131_3 - 1.2e-27 95.8 2.2 7.8e-08 32.3 0.0 7.5 8 0 0 8 8 8 5 Immunoglobulin domain V-set PF07686.15 T085131_3 - 2.3e-08 34.0 2.8 0.44 10.6 0.1 7.4 7 2 0 7 7 7 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 T085131_3 - 3.1e-05 23.8 0.8 0.48 10.4 0.0 4.3 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain ASXH PF13919.4 T160664_1 - 8.5e-34 116.3 0.2 2.1e-33 115.0 0.2 1.7 1 0 0 1 1 1 1 Asx homology domain HARE-HTH PF05066.11 T160664_1 - 7.6e-13 48.5 0.0 4e-06 27.0 0.1 2.5 2 0 0 2 2 2 2 HB1, ASXL, restriction endonuclease HTH domain K_channel_TID PF07941.9 T160664_2 - 0.56 10.6 11.0 1.2 9.5 11.0 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain PHD_3 PF13922.4 T160664_3 - 3.9e-21 75.1 8.3 1.1e-20 73.7 8.3 1.7 1 0 0 1 1 1 1 PHD domain of transcriptional enhancer, Asx NCU-G1 PF15065.4 T022413_1 - 2.1e-80 270.3 0.1 2.4e-57 194.4 0.0 2.1 1 1 1 2 2 2 2 Lysosomal transcription factor, NCU-G1 RVP PF00077.18 T174246_2 - 4e-07 30.1 0.0 7.2e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_1 PF00078.25 T174246_2 - 0.086 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) COX7a PF02238.13 T174246_3 - 1.1e-07 32.0 0.5 2.8e-07 30.7 0.0 2.1 3 0 0 3 3 3 1 Cytochrome c oxidase subunit VII zf-CCHC PF00098.21 T174246_3 - 0.0058 16.5 1.7 0.0058 16.5 1.7 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T174246_3 - 0.63 9.7 11.0 0.57 9.8 1.1 2.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger CCDC117 PF15810.3 T231698_2 - 6.8e-56 188.4 1.7 1e-55 187.8 1.7 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 117 Laminin_G_2 PF02210.22 T189305_1 - 7.6e-160 524.1 8.2 2e-27 96.2 0.2 6.3 6 0 0 6 6 6 6 Laminin G domain Laminin_G_1 PF00054.21 T189305_1 - 1.4e-112 371.3 1.6 3e-23 82.4 0.0 6.3 6 0 0 6 6 6 6 Laminin G domain Laminin_G_3 PF13385.4 T189305_1 - 1e-23 84.0 3.9 0.0012 18.9 0.1 6.4 6 0 0 6 6 6 5 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 T189305_1 - 7.1e-11 42.1 27.2 2.8e-05 24.2 6.8 3.7 3 0 0 3 3 3 3 EGF-like domain Syndecan PF01034.18 T189305_1 - 4.8e-07 29.5 0.0 1.2e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Syndecan domain hEGF PF12661.5 T189305_1 - 0.0062 17.0 26.6 0.22 12.1 4.8 4.0 3 0 0 3 3 3 2 Human growth factor-like EGF DUF1080 PF06439.9 T189305_1 - 0.035 14.1 0.4 22 4.9 0.0 4.1 5 0 0 5 5 5 0 Domain of Unknown Function (DUF1080) DUF202 PF02656.13 T189305_1 - 0.13 12.5 0.0 0.31 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) RINGv PF12906.5 T279297_1 - 9.1e-12 44.8 8.6 9.1e-12 44.8 8.6 2.0 2 0 0 2 2 2 1 RING-variant domain ABC_cobalt PF09819.7 T279297_1 - 0.064 13.3 2.9 0.11 12.5 2.9 1.3 1 0 0 1 1 1 0 ABC-type cobalt transport system, permease component HAP1_N PF04849.11 T147539_1 - 2.6e-99 332.2 28.2 8.4e-96 320.7 19.6 2.1 2 0 0 2 2 2 2 HAP1 N-terminal conserved region CDC45 PF02724.12 T147539_1 - 0.063 11.4 6.1 0.098 10.8 6.1 1.2 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.10 T147539_1 - 0.76 9.0 6.6 1.4 8.1 6.6 1.3 1 0 0 1 1 1 0 NOA36 protein HAP1_N PF04849.11 T147539_3 - 1.7e-06 27.4 0.2 2.3e-06 26.9 0.2 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region PMG PF05287.10 T224938_3 - 1.1e-59 201.4 70.4 5.8e-56 189.2 50.0 2.6 1 1 1 2 2 2 2 PMG protein PH PF00169.27 T028598_1 - 4.6e-20 72.0 0.1 9.3e-20 71.0 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 T028598_1 - 7.1e-09 35.9 0.1 1.4e-08 35.0 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 T028598_1 - 0.0018 18.3 0.0 0.0052 16.9 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain Tropomyosin_1 PF12718.5 T028598_1 - 0.53 10.3 8.7 1.5 8.9 8.7 1.7 1 1 0 1 1 1 0 Tropomyosin like DUF3915 PF13054.4 T028598_1 - 2 8.3 3.3 4.6 7.1 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) TMF_DNA_bd PF12329.6 T028598_1 - 2.1 8.3 5.9 18 5.3 0.8 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding FliJ PF02050.14 T028598_1 - 5.4 7.1 7.5 4.6 7.4 3.0 2.5 2 0 0 2 2 2 0 Flagellar FliJ protein GAS PF13851.4 T028598_1 - 7.6 5.7 10.0 15 4.7 10.0 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding 7tm_1 PF00001.19 T246200_2 - 3.7e-70 236.1 8.4 5.4e-70 235.5 8.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) RRM_1 PF00076.20 T128454_1 - 1e-07 31.5 0.0 0.0049 16.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.22 T128454_1 - 1.6e-07 31.9 0.0 4.6e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 Exonuclease Glyco_transf_7N PF13733.4 T009653_1 - 7.5e-55 184.1 0.0 1.2e-54 183.5 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 T009653_1 - 1.3e-30 104.7 2.8 2.2e-30 104.0 0.4 2.4 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase CCDC24 PF15669.3 T009653_1 - 3.8e-28 98.6 12.3 5.9e-25 88.2 0.5 3.0 3 0 0 3 3 3 2 Coiled-coil domain-containing protein 24 family Glyco_tranf_2_2 PF10111.7 T009653_1 - 0.044 13.1 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 CCDC24 PF15669.3 T009653_3 - 5.4e-22 78.5 0.0 8.7e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family zf-SAP30 PF13866.4 T274513_3 - 1.6e-34 117.7 3.7 3.7e-34 116.5 3.7 1.6 1 0 0 1 1 1 1 SAP30 zinc-finger SAP30_Sin3_bdg PF13867.4 T274513_3 - 1.2e-20 73.4 0.0 2.3e-20 72.5 0.0 1.5 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 SCAN PF02023.15 T182316_3 - 2e-34 117.2 0.7 3.2e-34 116.5 0.7 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 T182316_3 - 0.00026 21.2 5.7 0.24 11.8 0.3 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type Zn_ribbon_recom PF13408.4 T182316_3 - 0.34 11.3 2.4 0.7 10.3 2.4 1.4 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-H2C2_2 PF13465.4 T182316_3 - 0.37 11.2 11.3 30 5.2 3.7 3.7 3 0 0 3 3 3 0 Zinc-finger double domain Ldh_1_N PF00056.21 T055728_1 - 3.6e-96 318.7 5.7 6.8e-49 165.5 0.7 2.2 2 0 0 2 2 2 2 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 T055728_1 - 1.6e-52 177.7 0.0 1.3e-25 90.1 0.0 3.3 3 0 0 3 3 3 3 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 T055728_1 - 0.00075 19.0 2.7 0.37 10.2 0.0 2.6 3 0 0 3 3 3 2 Family 4 glycosyl hydrolase Pyr_redox_2 PF07992.12 T055728_1 - 0.00087 18.5 0.0 0.54 9.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Ldh_1_N PF00056.21 T055728_2 - 2.8e-37 127.8 0.1 3.9e-37 127.3 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 T055728_2 - 0.0064 16.3 0.0 0.0096 15.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain UDPG_MGDP_dh_N PF03721.12 T055728_2 - 0.12 11.8 0.2 0.18 11.2 0.2 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain MIP PF00230.18 T064503_2 - 1.1e-05 25.1 6.7 0.00014 21.5 6.6 2.0 1 1 1 2 2 2 2 Major intrinsic protein TMEM223 PF14640.4 T060216_1 - 2.8e-56 190.1 0.0 4.1e-56 189.5 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 223 SNARE PF05739.17 T060216_1 - 3e-15 55.8 0.6 5.4e-15 55.0 0.6 1.4 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.6 T060216_1 - 1.6e-10 39.7 1.2 3.9e-10 38.5 1.2 1.7 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.23 T060216_1 - 0.01 15.4 14.3 0.14 11.7 14.1 2.2 1 1 0 1 1 1 0 Syntaxin DUF16 PF01519.14 T060216_1 - 0.78 10.1 8.8 0.61 10.5 2.4 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 SKA1 PF07160.10 T060216_1 - 3.7 7.2 9.2 5 6.8 1.5 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Tap-RNA_bind PF09162.8 T060216_2 - 2.2e-38 129.8 0.2 3.5e-38 129.2 0.2 1.3 1 0 0 1 1 1 1 Tap, RNA-binding LRR_4 PF12799.5 T060216_2 - 0.00033 20.8 7.4 0.0024 18.1 1.5 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T060216_2 - 0.00047 19.7 5.6 0.00089 18.8 5.6 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_9 PF14580.4 T060216_2 - 0.12 11.7 0.3 0.2 11.0 0.3 1.2 1 0 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.31 T060216_2 - 0.85 10.2 4.8 22 5.9 0.2 4.2 3 0 0 3 3 3 0 Leucine Rich Repeat NTF2 PF02136.18 T060216_3 - 3.8e-27 95.1 0.0 5.3e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain TAP_C PF03943.11 T060216_3 - 1.4e-24 85.3 0.9 2.7e-24 84.4 0.9 1.5 1 0 0 1 1 1 1 TAP C-terminal domain FAD_binding_4 PF01565.21 T211841_1 - 9.8e-11 41.4 1.2 4.5e-10 39.3 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain FAD_binding_4 PF01565.21 T211841_2 - 9.1e-14 51.2 0.2 2.1e-13 50.1 0.2 1.6 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.17 T211841_3 - 9e-51 172.8 0.0 4.7e-38 131.1 0.0 2.1 2 0 0 2 2 2 2 FAD linked oxidases, C-terminal domain E1-E2_ATPase PF00122.18 T257232_2 - 2e-32 112.2 0.2 2.8e-32 111.7 0.2 1.2 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.6 T257232_2 - 6.9e-31 106.8 0.6 1.3e-30 106.0 0.6 1.5 1 0 0 1 1 1 1 P5-type ATPase cation transporter Cation_ATPase_N PF00690.24 T257232_2 - 2.1e-08 33.6 0.0 5.1e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 T257232_2 - 4e-08 33.7 0.1 2.4e-07 31.1 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.4 T257232_2 - 5.3e-05 23.1 0.0 9.8e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Pkinase PF00069.23 T000944_3 - 1.6e-65 221.0 0.0 2.4e-65 220.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T000944_3 - 8.5e-30 103.8 0.0 1.3e-29 103.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T000944_3 - 9.1e-05 21.8 0.2 0.0019 17.4 0.0 2.1 1 1 0 2 2 2 1 Kinase-like MIP-T3 PF10243.7 T000944_3 - 1.9 7.0 49.7 3.4 6.1 49.7 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 UCH PF00443.27 T380270_1 - 8.4e-52 176.1 0.0 2.1e-51 174.8 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_N PF16674.3 T380270_1 - 1.2e-41 140.8 0.8 3.1e-41 139.5 0.8 1.8 1 0 0 1 1 1 1 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 UCH_1 PF13423.4 T380270_1 - 1.1e-18 67.8 18.5 2.3e-15 56.9 1.5 2.6 2 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase BACK PF07707.13 T321347_2 - 3.8e-27 94.2 3.3 7.6e-27 93.3 3.3 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_1 PF01344.23 T321347_2 - 2.7e-15 55.5 12.2 1.7e-08 33.8 0.1 6.0 4 3 0 4 4 4 3 Kelch motif Kelch_6 PF13964.4 T321347_2 - 2.4e-14 52.9 1.5 0.0011 19.0 0.0 4.1 4 0 0 4 4 4 3 Kelch motif BTB PF00651.29 T321347_2 - 1.2e-11 44.7 1.4 4e-11 43.0 0.3 2.0 1 1 1 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.13 T321347_2 - 5.9e-06 25.9 4.6 0.4 10.6 0.0 4.8 4 1 0 4 4 4 2 Kelch motif Kelch_4 PF13418.4 T321347_2 - 1.1e-05 25.2 0.1 0.3 10.9 0.0 3.8 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.4 T321347_2 - 0.00073 19.6 1.2 1.8 8.8 0.0 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain DUF4510 PF14971.4 T111920_1 - 1.2e-72 243.3 12.1 2.1e-72 242.5 12.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4510) DUF4509 PF14970.4 T111920_1 - 8.9e-55 185.4 0.0 2.7e-54 183.8 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4509) LIM PF00412.20 T111920_3 - 9.8e-14 51.2 6.6 1.9e-13 50.3 6.6 1.5 1 0 0 1 1 1 1 LIM domain SMK-1 PF04802.13 T189717_1 - 4.1e-80 268.0 5.9 6.2e-80 267.5 5.9 1.3 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 Ran_BP1 PF00638.16 T189717_1 - 0.085 13.0 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 RanBP1 domain RNase_PH PF01138.19 T189717_2 - 4.3e-38 130.7 0.0 3.8e-19 69.4 0.0 2.3 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 T189717_2 - 7.5e-15 54.6 0.6 8.4e-11 41.6 0.0 2.4 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 PNPase PF03726.12 T189717_2 - 2.2e-07 31.2 0.5 3.9e-07 30.3 0.5 1.4 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain KH_1 PF00013.27 T189717_2 - 2.9e-06 26.9 0.0 7.6e-06 25.5 0.0 1.7 2 0 0 2 2 2 1 KH domain S1 PF00575.21 T189717_2 - 0.0014 18.8 0.0 0.0025 18.0 0.0 1.5 1 0 0 1 1 1 1 S1 RNA binding domain Transglut_C PF00927.20 T212635_3 - 3.3e-50 168.5 0.1 4.4e-25 87.7 0.1 2.4 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.18 T212635_3 - 3.6e-33 114.3 0.0 6.9e-33 113.4 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.17 T212635_3 - 5.9e-16 58.8 0.1 1.1e-15 57.9 0.1 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily SSXRD PF09514.8 T139061_1 - 6.7e-17 60.6 1.1 1.7e-16 59.4 1.1 1.7 1 0 0 1 1 1 1 SSXRD motif zf-H2C2_2 PF13465.4 T139061_1 - 4.9e-07 29.8 0.9 6.5e-06 26.2 0.3 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.24 T139061_1 - 8.2e-07 29.0 6.4 0.00083 19.5 0.6 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T139061_1 - 0.012 16.3 6.8 0.093 13.5 0.7 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T139061_2 - 0.0023 18.1 0.1 0.0023 18.1 0.1 4.8 5 0 0 5 5 5 1 Zinc-finger double domain zf-C2H2 PF00096.24 T139061_2 - 0.073 13.4 0.0 0.073 13.4 0.0 4.4 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T139061_2 - 0.17 12.7 19.9 0.94 10.4 3.9 5.0 4 0 0 4 4 4 0 C2H2-type zinc finger PhoLip_ATPase_C PF16212.3 T164760_1 - 2.9e-50 171.2 19.7 5.2e-50 170.4 19.7 1.4 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 T164760_1 - 8.3e-18 63.8 0.9 1.8e-17 62.7 0.9 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.18 T164760_1 - 2.2e-12 46.7 0.0 3.6e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.24 T164760_1 - 9.3e-12 45.5 0.0 4.2e-10 40.1 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.4 T164760_1 - 8.1e-07 28.9 0.0 2.2e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.10 T164760_1 - 0.026 14.1 0.0 0.044 13.4 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase RNF220 PF15926.3 T009772_3 - 2e-80 269.9 10.9 6.2e-47 160.2 0.4 2.7 2 1 1 3 3 3 2 E3 ubiquitin-protein ligase RNF220 zf-C3HC4_2 PF13923.4 T009772_3 - 2.3e-13 49.6 11.1 2.3e-13 49.6 11.1 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T009772_3 - 0.00032 20.3 7.6 0.00032 20.3 7.6 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T009772_3 - 0.002 17.9 7.8 0.002 17.9 7.8 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.23 T009772_3 - 0.003 17.3 9.8 0.003 17.3 9.8 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T009772_3 - 0.0066 16.6 10.6 0.0066 16.6 10.6 3.2 3 0 0 3 3 3 1 Ring finger domain Endonuclease_7 PF02945.13 T009772_3 - 0.031 14.1 5.1 0.12 12.2 1.5 2.5 2 0 0 2 2 2 0 Recombination endonuclease VII Pox_A_type_inc PF04508.10 T009772_3 - 0.095 12.5 0.4 0.23 11.2 0.4 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat bZIP_2 PF07716.13 T150896_3 - 1.7e-16 59.9 12.7 2.8e-16 59.2 12.7 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.19 T150896_3 - 0.00066 19.6 9.0 0.0013 18.6 9.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.15 T150896_3 - 0.0085 16.5 2.8 0.014 15.7 2.8 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Cnn_1N PF07989.9 T150896_3 - 0.14 12.2 0.6 0.26 11.3 0.6 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 PAP2 PF01569.19 T165112_1 - 7.7e-26 90.4 4.0 9.8e-26 90.0 2.9 1.7 2 0 0 2 2 2 1 PAP2 superfamily LrgB PF04172.14 T165112_1 - 0.037 13.4 0.3 0.064 12.6 0.3 1.3 1 0 0 1 1 1 0 LrgB-like family PAP2_C PF14360.4 T165112_1 - 0.067 13.6 3.4 0.17 12.3 3.4 1.7 1 0 0 1 1 1 0 PAP2 superfamily C-terminal UbiA PF01040.16 T165112_1 - 0.59 9.2 6.3 0.14 11.3 0.3 2.2 2 0 0 2 2 2 0 UbiA prenyltransferase family Pep_M12B_propep PF01562.17 T342597_2 - 6.2e-23 81.5 0.0 8.5e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 Reprolysin family propeptide PGM_PMM_I PF02878.14 T012445_2 - 1.1e-38 131.9 0.3 1.6e-38 131.4 0.3 1.2 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.14 T012445_2 - 2.8e-30 104.7 0.0 4.3e-30 104.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.14 T012445_2 - 9.5e-17 61.4 0.0 1.8e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.18 T012445_2 - 7e-05 22.8 0.0 0.00015 21.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RINGv PF12906.5 T273920_2 - 6.3e-15 54.9 16.4 1.6e-14 53.6 16.4 1.8 1 0 0 1 1 1 1 RING-variant domain Spatacsin_C PF14649.4 T115760_3 - 2.8e-102 341.7 4.5 7.3e-102 340.4 4.5 1.7 1 0 0 1 1 1 1 Spatacsin C-terminus 7tm_1 PF00001.19 T024647_1 - 2e-44 151.7 17.9 3.6e-44 150.9 17.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 T024647_1 - 0.0014 17.9 15.2 0.0014 17.9 15.2 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MRF_C2 PF13888.4 T059869_1 - 4e-42 143.2 0.1 6.9e-42 142.5 0.1 1.4 1 0 0 1 1 1 1 Myelin gene regulatory factor C-terminal domain 2 NDT80_PhoG PF05224.10 T059869_1 - 5.2e-28 98.4 0.6 2.2e-27 96.3 0.6 1.9 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family MRF_C1 PF13887.4 T059869_1 - 1.8e-22 78.0 1.0 2.8e-22 77.4 1.0 1.3 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 Peptidase_S74 PF13884.4 T059869_1 - 7e-13 48.6 0.0 1.2e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 Chaperone of endosialidase CAP_N PF01213.17 T059869_1 - 9.3 5.5 8.0 27 4.0 8.0 1.8 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF2043 PF09740.7 T259345_1 - 9.1e-05 23.0 1.4 0.00021 21.8 1.4 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2043) DUF2043 PF09740.7 T259345_3 - 3.2e-24 85.5 0.0 3.2e-24 85.5 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2043) Ion_trans PF00520.29 T370327_2 - 1.1e-222 735.3 74.3 2.5e-67 226.5 1.6 5.2 4 1 1 5 5 5 5 Ion transport protein GPHH PF16905.3 T370327_2 - 5e-35 119.0 0.0 1.7e-34 117.3 0.0 2.0 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 T370327_2 - 2.3e-31 107.7 0.0 5.3e-31 106.6 0.0 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 T370327_2 - 1.4e-05 23.8 10.4 1.4e-05 23.8 10.4 9.1 7 3 2 10 10 10 5 Polycystin cation channel DUF2207 PF09972.7 T370327_2 - 1.7 7.2 8.4 2.2 6.8 0.3 3.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) KH_1 PF00013.27 T079308_1 - 1.1e-46 156.4 15.8 4.9e-17 61.4 0.8 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 T079308_1 - 4.6e-12 45.4 5.4 0.00066 19.3 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 T079308_1 - 0.00027 20.6 3.3 1 9.1 0.3 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 T079308_1 - 0.041 13.8 6.8 3.8 7.5 0.1 3.2 3 0 0 3 3 3 0 NusA-like KH domain VWA PF00092.26 T301266_2 - 5.9e-36 124.2 0.4 7.8e-36 123.8 0.4 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain Trypsin PF00089.24 T301266_2 - 1.7e-29 103.1 0.0 6.9e-29 101.1 0.0 1.8 1 1 0 1 1 1 1 Trypsin VWA_2 PF13519.4 T301266_2 - 4.5e-10 40.0 0.2 7.4e-10 39.3 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Sushi PF00084.18 T301266_2 - 2.3e-07 31.2 0.3 4.9e-07 30.1 0.3 1.6 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) DUF1986 PF09342.9 T301266_2 - 0.00039 20.7 0.0 0.00088 19.5 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 T301266_2 - 0.01 16.6 0.0 0.029 15.1 0.0 1.7 1 1 0 1 1 1 0 Trypsin-like peptidase domain Trypsin PF00089.24 T301266_3 - 5e-47 160.4 0.1 7.5e-47 159.8 0.1 1.3 1 0 0 1 1 1 1 Trypsin VWA PF00092.26 T301266_3 - 2.3e-39 135.3 0.0 3.3e-39 134.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Sushi PF00084.18 T301266_3 - 1.1e-24 86.7 18.1 2e-10 41.0 2.7 4.3 4 0 0 4 4 4 3 Sushi repeat (SCR repeat) VWA_2 PF13519.4 T301266_3 - 2.2e-10 41.0 0.0 5.6e-10 39.7 0.0 1.6 1 1 0 1 1 1 1 von Willebrand factor type A domain DUF1986 PF09342.9 T301266_3 - 0.00024 21.3 0.0 0.00043 20.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) HRM PF02793.20 T301266_3 - 0.0022 18.1 10.0 3 8.1 0.7 3.7 2 1 1 3 3 3 3 Hormone receptor domain Trypsin_2 PF13365.4 T301266_3 - 0.018 15.7 0.0 0.053 14.3 0.0 1.8 1 1 0 1 1 1 0 Trypsin-like peptidase domain EF-hand_1 PF00036.30 T000529_2 - 9.3e-16 56.0 0.1 0.059 12.8 0.0 5.6 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.4 T000529_2 - 3.4e-13 49.7 4.1 9.2e-07 29.1 0.1 3.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 T000529_2 - 3.6e-08 32.4 0.2 0.04 13.3 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.4 T000529_2 - 4e-08 32.4 0.2 2.8 8.0 0.0 4.9 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 T000529_2 - 0.00021 20.8 0.4 0.015 14.9 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain pair SPARC_Ca_bdg PF10591.7 T000529_2 - 0.017 15.3 6.4 1.4 9.1 0.1 3.1 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region TNFR_c6 PF00020.16 T000529_3 - 1.4e-13 50.9 76.4 8.8e-07 29.1 7.5 7.4 7 0 0 7 7 7 4 TNFR/NGFR cysteine-rich region Peptidase_M3 PF01432.18 T091495_2 - 3.4e-145 484.7 0.0 4.2e-145 484.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 C1q PF00386.19 T091495_2 - 2.9e-13 50.0 0.1 4.9e-13 49.3 0.1 1.3 1 0 0 1 1 1 1 C1q domain Peptidase_M91 PF14891.4 T091495_2 - 0.058 13.6 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Effector protein Collagen PF01391.16 T091495_3 - 8.5e-05 22.1 34.2 0.00042 19.9 9.2 3.2 3 0 0 3 3 3 2 Collagen triple helix repeat (20 copies) OAS1_C PF10421.7 T086734_2 - 0 1086.6 1.7 3e-85 284.3 0.8 4.2 4 0 0 4 4 4 4 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus NTP_transf_2 PF01909.21 T086734_2 - 1.5e-22 79.5 6.5 2.3e-09 37.3 0.0 4.8 5 0 0 5 5 5 4 Nucleotidyltransferase domain RNA_pol_Rpc4 PF05132.12 T086734_2 - 4.7 7.5 7.9 11 6.3 7.9 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 RNA_pol_Rpc4 PF05132.12 T086734_3 - 6.6 7.0 7.3 14 6.0 7.3 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Pkinase PF00069.23 T144438_1 - 1.3e-62 211.5 0.0 1.8e-62 210.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T144438_1 - 9.8e-30 103.6 0.0 1.5e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T144438_1 - 0.1 11.7 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Hormone_5 PF00184.15 T212786_2 - 1.4e-30 105.8 25.0 5.6e-30 103.9 25.0 2.2 1 0 0 1 1 1 1 Neurohypophysial hormones, C-terminal Domain GnRH PF00446.15 T212786_2 - 0.011 15.9 10.7 0.066 13.5 10.7 2.5 1 0 0 1 1 1 0 Gonadotropin-releasing hormone Hormone_4 PF00220.15 T212786_2 - 0.17 11.8 8.9 0.036 13.9 3.9 2.8 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain Y_phosphatase PF00102.25 T212786_3 - 1.4e-166 551.6 9.2 5.8e-84 281.2 0.5 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase MRP-S26 PF14943.4 T212786_3 - 1.9e-50 171.0 16.5 3.1e-50 170.3 16.5 1.4 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S26 DSPc PF00782.18 T212786_3 - 6.9e-08 32.3 0.8 0.006 16.3 0.3 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 T212786_3 - 2e-07 31.1 0.0 0.0022 17.9 0.0 2.5 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 T212786_3 - 0.0014 18.7 8.0 0.044 13.8 0.1 3.4 3 0 0 3 3 3 2 Inositol hexakisphosphate SMC_N PF02463.17 T235175_2 - 0.0002 20.8 0.0 0.00028 20.2 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_N PF02463.17 T235175_3 - 5.3e-36 124.0 0.4 1.6e-35 122.4 0.4 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 T235175_3 - 1.2e-19 70.6 0.0 3.4e-19 69.1 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.4 T235175_3 - 3e-09 36.8 12.0 3e-09 36.8 12.0 4.7 2 2 2 4 4 4 1 AAA ATPase domain AAA_21 PF13304.4 T235175_3 - 4.7e-07 29.8 0.3 4.7e-07 29.8 0.3 3.0 3 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 T235175_3 - 9.6e-06 25.1 0.0 2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATPase-cat_bd PF12156.6 T235175_3 - 0.024 15.2 1.1 0.23 12.1 0.2 3.1 2 0 0 2 2 2 0 Putative metal-binding domain of cation transport ATPase RhoGAP PF00620.25 T174053_1 - 3.8e-45 153.3 0.0 8.8e-45 152.1 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain SH3_2 PF07653.15 T174053_1 - 1.5e-10 40.5 0.0 3.3e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T174053_1 - 1.6e-10 40.6 0.0 3e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T174053_1 - 2.8e-09 36.3 0.0 5e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain PX PF00787.22 T174053_1 - 0.00054 19.8 0.0 0.0014 18.5 0.0 1.6 1 0 0 1 1 1 1 PX domain CATSPERB PF15149.4 T109019_2 - 2.2e-275 914.0 1.0 2.8e-275 913.6 1.0 1.1 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit beta protein family AAA_18 PF13238.4 T360535_3 - 1.6e-11 44.7 0.0 2.6e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 T360535_3 - 0.019 15.0 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Bromodomain PF00439.23 T277223_1 - 5.1e-22 77.6 0.1 8.5e-22 76.9 0.1 1.3 1 0 0 1 1 1 1 Bromodomain DUF3512 PF12024.6 T277223_1 - 1.7e-08 34.1 0.0 2.4e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3512) DUF3512 PF12024.6 T277223_2 - 1.5e-66 224.2 1.7 2.8e-66 223.3 1.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3512) YadA_head PF05658.12 T277223_2 - 0.14 12.4 14.9 0.73 10.2 1.4 3.4 3 0 0 3 3 3 0 Head domain of trimeric autotransporter adhesin SR-25 PF10500.7 T277223_2 - 0.52 9.7 15.7 0.93 8.9 15.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med19 PF10278.7 T277223_2 - 0.83 9.4 19.8 1.6 8.5 19.8 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 TFIIF_alpha PF05793.10 T277223_2 - 2 6.8 17.3 2.9 6.2 17.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) zf-DHHC PF01529.18 T277223_3 - 3.9e-19 69.0 10.8 3.9e-19 69.0 10.8 4.7 4 0 0 4 4 4 2 DHHC palmitoyltransferase YadA_head PF05658.12 T277223_3 - 0.25 11.6 11.4 0.65 10.3 3.1 2.5 2 0 0 2 2 2 0 Head domain of trimeric autotransporter adhesin Ig_2 PF13895.4 T180922_1 - 1.3e-29 102.2 1.3 3.3e-14 52.8 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 T180922_1 - 1.9e-24 85.9 2.8 1.1e-05 25.8 0.2 4.6 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 T180922_1 - 2.1e-14 53.3 0.3 0.00023 21.2 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 T180922_1 - 0.068 13.2 3.8 22 5.1 0.5 4.9 3 2 1 4 4 4 0 Immunoglobulin V-set domain EphA2_TM PF14575.4 T180922_1 - 0.15 12.8 0.0 0.55 10.9 0.0 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SIT PF15330.4 T180922_1 - 0.2 11.9 1.6 1.7 9.0 0.1 2.5 1 1 2 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT DUF4131 PF13567.4 T180922_1 - 0.7 9.3 3.0 9.5 5.7 1.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) ATG16 PF08614.9 T090436_3 - 0.0003 20.9 25.0 0.0003 20.9 25.0 10.5 1 1 8 9 9 9 2 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.7 T090436_3 - 0.0029 17.5 12.4 0.0029 17.5 12.4 11.0 2 1 6 10 10 10 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.6 T090436_3 - 0.0047 17.0 21.1 0.0047 17.0 21.1 12.7 2 1 9 14 14 14 1 TATA element modulatory factor 1 TATA binding Reo_sigmaC PF04582.10 T090436_3 - 1.3 8.2 85.8 0.094 12.0 5.1 8.8 3 2 5 9 9 9 0 Reovirus sigma C capsid protein XPG_I PF00867.16 T034003_2 - 4.2e-23 81.4 0.2 8.2e-23 80.4 0.2 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.15 T034003_2 - 1.2e-21 77.0 0.0 2e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.5 T034003_2 - 0.0062 15.9 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 XPG domain containing TTL PF03133.13 T216071_1 - 3.7e-83 278.9 2.4 6.9e-55 186.1 0.9 2.1 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 T216071_1 - 2.2e-09 36.8 0.1 1.7e-05 24.1 0.0 3.3 3 1 0 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 T216071_1 - 0.0011 18.2 0.0 0.017 14.2 0.0 2.3 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp RimK PF08443.9 T216071_1 - 0.15 11.5 0.0 0.6 9.5 0.0 1.9 3 0 0 3 3 3 0 RimK-like ATP-grasp domain CCDC144C PF14915.4 T158899_2 - 5.4e-113 377.0 54.4 5.4e-113 377.0 54.4 3.3 3 0 0 3 3 3 1 CCDC144C protein coiled-coil region Ank_4 PF13637.4 T158899_2 - 5.5e-29 100.0 4.1 7.9e-09 35.8 0.1 5.7 2 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.5 T158899_2 - 2.8e-26 91.8 6.8 1.3e-09 38.4 0.9 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T158899_2 - 7.6e-26 89.6 7.9 9e-10 38.5 0.6 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 T158899_2 - 1.1e-18 66.7 3.3 0.00018 21.7 0.0 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.4 T158899_2 - 2.5e-18 64.1 5.4 0.00018 21.5 0.1 6.2 6 0 0 6 6 6 4 Ankyrin repeat Dynein_IC2 PF11540.6 T202901_3 - 1.6e-15 56.6 0.6 3.4e-15 55.5 0.6 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 T202901_3 - 0.0069 17.1 18.1 0.29 11.9 0.6 7.3 8 0 0 8 8 8 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T202901_3 - 0.0093 16.1 0.2 0.075 13.2 0.0 2.6 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain COesterase PF00135.26 T351969_1 - 6e-08 31.9 0.0 8e-08 31.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family HMG_box PF00505.17 T092390_1 - 1.2e-41 140.8 13.1 6.6e-26 90.4 0.7 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.8 T092390_1 - 1.2e-40 137.8 14.3 8.1e-26 90.3 8.3 2.4 2 0 0 2 2 2 2 HMG-box domain RNA_pol_3_Rpc31 PF11705.6 T092390_1 - 0.018 15.1 25.6 0.03 14.4 25.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 HMG_box_5 PF14887.4 T092390_1 - 0.32 10.9 12.9 1.9 8.4 2.2 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box 5 Afi1 PF07792.10 T092390_1 - 0.89 9.9 8.1 2 8.7 8.1 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Nucleo_P87 PF07267.9 T092390_1 - 1.2 7.8 9.2 1.5 7.4 9.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 BUD22 PF09073.8 T333840_2 - 0.0012 18.1 9.1 0.0017 17.6 9.1 1.1 1 0 0 1 1 1 1 BUD22 RNA_pol_3_Rpc31 PF11705.6 T333840_2 - 0.0023 18.1 14.2 0.0033 17.5 14.2 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.10 T333840_2 - 0.011 13.9 13.4 0.016 13.3 13.4 1.2 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.9 T333840_2 - 0.068 12.6 15.9 0.1 12.1 15.9 1.1 1 0 0 1 1 1 0 PPP4R2 SDA1 PF05285.10 T333840_2 - 0.11 11.8 18.1 0.16 11.3 18.1 1.1 1 0 0 1 1 1 0 SDA1 Myc_N PF01056.16 T333840_2 - 0.14 11.9 8.8 0.23 11.2 8.8 1.2 1 0 0 1 1 1 0 Myc amino-terminal region DUF4746 PF15928.3 T333840_2 - 0.15 11.3 14.2 0.24 10.7 14.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1777 PF08648.10 T333840_2 - 0.41 10.7 5.9 0.66 10.1 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) NOA36 PF06524.10 T333840_2 - 0.5 9.6 15.9 0.92 8.7 15.9 1.3 1 0 0 1 1 1 0 NOA36 protein Sigma70_ner PF04546.11 T333840_2 - 0.53 10.0 13.2 0.85 9.3 13.2 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region RNA_pol_Rpc4 PF05132.12 T333840_2 - 0.78 10.0 3.8 1.3 9.4 3.8 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 CPSF100_C PF13299.4 T333840_2 - 0.81 9.7 4.6 1.4 9.0 4.6 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF740 PF05340.10 T333840_2 - 0.99 8.0 8.0 1.4 7.4 8.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) SpoIIP PF07454.9 T333840_2 - 1.2 8.4 7.5 1.7 7.9 7.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.12 T333840_2 - 1.3 7.2 13.1 1.8 6.6 13.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1682 PF07946.12 T333840_2 - 1.3 8.0 10.7 1.9 7.5 10.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RNA_polI_A34 PF08208.9 T333840_2 - 1.3 8.9 11.4 2.1 8.3 11.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Presenilin PF01080.15 T333840_2 - 1.7 7.2 4.5 2.5 6.6 4.5 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.10 T333840_2 - 1.9 8.1 11.2 2.9 7.5 11.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1510 PF07423.9 T333840_2 - 2.9 7.1 19.1 4.4 6.5 19.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RXT2_N PF08595.9 T333840_2 - 3.1 7.7 9.1 5.3 6.9 9.1 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal RRN3 PF05327.9 T333840_2 - 3.2 6.1 7.8 4.9 5.4 7.8 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Vfa1 PF08432.8 T333840_2 - 3.2 7.9 10.8 5.5 7.2 10.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TRAP_alpha PF03896.14 T333840_2 - 3.4 6.7 13.3 5.4 6.0 13.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.4 T333840_2 - 4.8 6.7 12.9 8.1 6.0 12.9 1.3 1 0 0 1 1 1 0 FAM176 family AIF_C PF14721.4 T333840_2 - 5 7.4 5.8 8 6.7 5.8 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Astro_capsid_p PF12226.6 T333840_2 - 5.7 5.9 11.1 8.1 5.4 11.1 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF913 PF06025.10 T333840_2 - 6.3 5.5 5.8 9.7 4.9 5.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PTPRCAP PF15713.3 T333840_2 - 7.5 6.7 20.9 14 5.8 20.9 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Acyl-CoA_dh_N PF02771.14 T070889_1 - 2e-27 95.9 0.0 3.1e-27 95.4 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.17 T070889_1 - 8.8e-22 77.0 0.0 1.6e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.22 T070889_2 - 7.2e-35 120.3 3.6 1.2e-34 119.6 1.8 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.9 T070889_2 - 2.9e-19 69.5 2.0 4.3e-19 69.0 2.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Mtc PF03820.15 T191752_2 - 1.2e-115 385.8 0.0 2.5e-115 384.7 0.0 1.5 1 1 0 1 1 1 1 Tricarboxylate carrier Pkinase PF00069.23 T311729_1 - 1.6e-69 234.1 0.0 2.1e-69 233.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T311729_1 - 3.2e-35 121.5 0.0 4.6e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T311729_1 - 9.5e-07 28.3 0.0 1.9e-06 27.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 T311729_1 - 9.5e-06 26.1 0.1 2.2e-05 24.9 0.1 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.12 T311729_1 - 0.016 14.4 0.0 0.027 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 T311729_1 - 0.059 12.9 0.1 3.8 7.0 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PX PF00787.22 T311729_1 - 0.11 12.3 0.1 0.25 11.2 0.1 1.6 1 0 0 1 1 1 0 PX domain FHA PF00498.24 T347513_1 - 0.0063 16.7 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.3 T347513_1 - 0.023 14.9 0.0 0.036 14.2 0.0 1.2 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Nbs1_C PF08599.8 T347513_3 - 2e-34 117.5 0.2 8e-34 115.5 0.2 2.1 1 0 0 1 1 1 1 DNA damage repair protein Nbs1 NIBRIN_BRCT_II PF16508.3 T347513_3 - 9.6e-31 106.4 0.0 2e-30 105.4 0.0 1.6 1 0 0 1 1 1 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.24 T347513_3 - 3e-06 27.4 0.1 8.1e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 FHA domain RTT107_BRCT_5 PF16770.3 T347513_3 - 3.6e-05 23.5 0.0 8.1e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.24 T347513_3 - 0.0076 16.5 0.2 0.022 15.0 0.0 1.9 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.5 T347513_3 - 0.017 14.9 0.1 0.03 14.1 0.1 1.4 1 0 0 1 1 1 0 twin BRCT domain HAP1_N PF04849.11 T240848_2 - 9.8e-113 376.3 48.0 1.4e-112 375.8 48.0 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Milton PF12448.6 T240848_2 - 4.4e-67 225.4 6.3 9.2e-67 224.4 6.3 1.5 1 0 0 1 1 1 1 Kinesin associated protein KASH_CCD PF14662.4 T240848_2 - 0.0072 16.1 39.8 0.011 15.4 14.6 3.2 1 1 2 3 3 3 3 Coiled-coil region of CCDC155 or KASH ZapB PF06005.10 T240848_2 - 6.9 7.1 41.5 2.8 8.3 4.6 3.9 2 1 1 3 3 3 0 Cell division protein ZapB P2X_receptor PF00864.17 T087806_2 - 2.3e-97 326.2 1.2 2.9e-97 325.9 1.2 1.1 1 0 0 1 1 1 1 ATP P2X receptor P2X_receptor PF00864.17 T087806_3 - 1e-51 176.0 0.1 1.4e-51 175.5 0.1 1.1 1 0 0 1 1 1 1 ATP P2X receptor GHMP_kinases_N PF00288.24 T087806_3 - 0.064 13.3 1.2 1.6 8.8 0.0 2.6 2 0 0 2 2 2 0 GHMP kinases N terminal domain MmgE_PrpD PF03972.12 T096423_1 - 1.8e-16 59.6 0.0 2.3e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 MmgE/PrpD family MmgE_PrpD PF03972.12 T096423_3 - 1.7e-95 320.1 0.0 2.6e-95 319.4 0.0 1.3 1 0 0 1 1 1 1 MmgE/PrpD family Flavodoxin_5 PF12724.5 T141217_1 - 5 7.2 6.3 0.39 10.8 0.3 2.1 3 0 0 3 3 3 0 Flavodoxin domain PDZ PF00595.22 T078766_3 - 1.9e-11 44.0 0.0 3e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T078766_3 - 0.0017 18.5 0.0 0.0032 17.6 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Trypsin PF00089.24 T130644_1 - 5.3e-65 219.2 0.0 5.6e-43 147.2 0.1 2.1 2 0 0 2 2 2 2 Trypsin DUF1986 PF09342.9 T130644_1 - 8.2e-10 39.0 0.0 2.4e-05 24.5 0.0 2.7 2 1 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 T130644_1 - 6.2e-09 36.8 0.0 7e-06 26.8 0.0 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain VKOR PF07884.12 T130644_3 - 4.5e-25 88.1 12.8 8.2e-25 87.3 12.8 1.5 1 0 0 1 1 1 1 Vitamin K epoxide reductase family PRY PF13765.4 T143466_2 - 1.2e-16 59.9 0.2 2.7e-16 58.8 0.2 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 T143466_2 - 2.3e-11 43.7 0.2 3.7e-11 43.1 0.2 1.3 1 0 0 1 1 1 1 SPRY domain WD40 PF00400.30 T143466_3 - 9.2e-19 67.3 9.2 2.2e-05 25.0 0.6 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T143466_3 - 3.6e-05 23.8 0.0 20 5.4 0.0 4.5 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 T143466_3 - 0.051 12.1 0.1 2.3 6.6 0.1 3.1 3 1 1 4 4 4 0 Nucleoporin Nup120/160 DUF1725 PF08333.9 T135910_1 - 0.01 15.3 0.1 0.02 14.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) MYCBPAP PF14646.4 T150476_1 - 4e-140 467.5 1.5 4e-140 467.5 1.5 1.5 2 0 0 2 2 2 1 MYCBP-associated protein family ENTH PF01417.18 T150476_2 - 1.5e-49 167.1 0.0 2.2e-49 166.5 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.14 T150476_2 - 0.00016 20.6 0.0 0.00024 20.1 0.0 1.1 1 0 0 1 1 1 1 ANTH domain VHS PF00790.17 T150476_2 - 0.034 13.9 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 VHS domain UIM PF02809.18 T150476_2 - 0.099 12.5 7.3 0.21 11.5 7.3 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif Ribosomal_L1 PF00687.19 T266931_1 - 4.2e-16 59.1 0.5 5.8e-16 58.7 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family KRBA1 PF15287.4 T335441_3 - 5.2e-45 150.7 63.0 9.2e-18 63.5 6.4 7.1 6 0 0 6 6 6 5 KRBA1 family repeat KRAB PF01352.25 T335441_3 - 1.5e-19 69.2 0.8 2.7e-19 68.4 0.8 1.4 1 0 0 1 1 1 1 KRAB box Myosin_head PF00063.19 T144805_2 - 4.3e-112 375.4 0.0 3.6e-100 336.0 0.0 2.7 2 0 0 2 2 2 2 Myosin head (motor domain) Myosin_tail_1 PF01576.17 T144805_2 - 9.3e-19 66.7 182.4 3.7e-18 64.7 105.0 3.0 1 1 1 2 2 2 2 Myosin tail IQ PF00612.25 T144805_2 - 0.00047 19.6 0.3 0.0019 17.7 0.3 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif ATG16 PF08614.9 T144805_2 - 0.0014 18.7 17.1 0.0014 18.7 17.1 8.4 3 1 5 8 8 8 2 Autophagy protein 16 (ATG16) PKcGMP_CC PF16808.3 T144805_2 - 0.0021 17.8 2.7 0.0021 17.8 2.7 7.2 8 0 0 8 8 8 1 Coiled-coil N-terminus of cGMP-dependent protein kinase AAA_22 PF13401.4 T144805_2 - 0.019 15.1 0.0 0.12 12.6 0.0 2.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 T144805_2 - 0.082 13.2 0.0 0.082 13.2 0.0 5.3 4 1 1 5 5 5 0 AAA ATPase domain AAA_18 PF13238.4 T144805_2 - 0.093 13.1 1.8 0.5 10.7 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.4 T144805_2 - 0.15 12.3 1.1 0.38 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain Reo_sigmaC PF04582.10 T144805_2 - 0.45 9.7 43.0 0.051 12.8 4.3 6.0 3 1 4 7 7 7 0 Reovirus sigma C capsid protein Ras PF00071.20 T347894_1 - 8.4e-31 106.6 0.0 1.3e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T347894_1 - 2e-09 37.6 0.0 3.6e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF258 PF03193.14 T347894_1 - 0.00013 21.8 0.1 0.04 13.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 FeoB_N PF02421.16 T347894_1 - 0.00086 18.7 0.1 0.0034 16.8 0.1 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.25 T347894_1 - 0.0013 19.1 0.0 0.003 17.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.21 T347894_1 - 0.0044 17.0 0.0 0.0079 16.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 T347894_1 - 0.0099 16.0 0.3 0.53 10.4 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.4 T347894_1 - 0.012 15.7 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 T347894_1 - 0.025 14.1 0.3 0.11 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.4 T347894_1 - 0.095 12.9 0.0 0.19 12.0 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.12 T347894_1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NDK PF00334.17 T321791_2 - 3.1e-56 189.0 0.0 7.9e-31 106.7 0.0 2.7 2 1 1 3 3 3 2 Nucleoside diphosphate kinase Thioredoxin PF00085.18 T321791_3 - 9.1e-07 28.6 0.1 1.8e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin DUF1943 PF09172.9 T127372_2 - 3e-59 200.7 0.0 4.6e-59 200.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) Vitellogenin_N PF01347.20 T127372_2 - 5.5e-53 180.2 0.0 6.8e-53 179.9 0.0 1.1 1 0 0 1 1 1 1 Lipoprotein amino terminal region Peptidase_M3 PF01432.18 T166114_2 - 2.2e-160 534.8 0.0 2.8e-160 534.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 PLDc_2 PF13091.4 T155552_1 - 7.8e-11 41.9 0.0 0.0005 19.8 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.20 T155552_1 - 0.12 12.5 0.1 2.5 8.3 0.1 2.5 2 0 0 2 2 2 0 Phospholipase D Active site motif Striatin PF08232.10 T177741_1 - 1.5e-42 145.7 3.5 4.2e-42 144.2 3.5 1.8 1 1 0 1 1 1 1 Striatin family WD40 PF00400.30 T177741_1 - 3.4e-33 113.0 15.4 2.6e-09 37.4 0.4 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T177741_1 - 6.9e-09 35.8 0.0 0.096 12.9 0.0 4.4 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 T177741_1 - 0.00043 18.9 0.0 0.74 8.2 0.0 3.0 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.9 T177741_1 - 0.13 10.9 0.0 7.2 5.1 0.0 2.6 3 0 0 3 3 3 0 Nup133 N terminal like CENP-H PF05837.10 T177741_1 - 0.31 11.3 1.8 21 5.4 0.4 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Pkinase PF00069.23 T177741_3 - 7.6e-69 231.9 0.0 1e-68 231.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T177741_3 - 1.4e-31 109.6 0.0 2.1e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 T177741_3 - 6.2e-24 83.5 26.3 6.7e-13 48.2 2.6 2.9 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.14 T177741_3 - 1.6e-06 28.2 14.8 0.0051 17.0 5.4 2.8 2 0 0 2 2 2 2 C1 domain Kinase-like PF14531.4 T177741_3 - 0.00011 21.5 0.0 0.00056 19.2 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.12 T177741_3 - 0.00023 20.5 0.0 0.0004 19.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_9 PF13901.4 T177741_3 - 0.34 10.7 12.7 1.2 8.9 0.4 2.2 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD_2 PF13831.4 T177741_3 - 1.1 8.7 4.7 15 5.1 0.1 2.9 2 0 0 2 2 2 0 PHD-finger V-set PF07686.15 T043628_3 - 7.8e-08 32.3 0.1 2.1e-07 30.9 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 T043628_3 - 4e-05 23.6 0.4 0.0005 20.0 0.4 2.3 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 T043628_3 - 0.006 17.0 0.0 0.019 15.4 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Bromodomain PF00439.23 T015112_1 - 3.9e-40 135.7 6.1 1.2e-20 73.2 0.5 2.4 2 0 0 2 2 2 2 Bromodomain BET PF17035.3 T015112_1 - 6.4e-27 93.4 0.1 1.2e-26 92.5 0.1 1.5 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRD4_CDT PF17105.3 T015112_1 - 1.3e-21 75.8 5.3 2.5e-21 74.9 5.3 1.5 1 0 0 1 1 1 1 C-terminal domain of bromodomain protein 4 fn3 PF00041.19 T150991_3 - 1e-11 44.9 0.0 2.6e-11 43.6 0.0 1.7 2 0 0 2 2 2 1 Fibronectin type III domain Ank_4 PF13637.4 T150991_3 - 1.1e-06 28.9 0.0 4.2e-06 27.1 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.5 T150991_3 - 0.00047 20.6 0.0 0.0011 19.3 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Pur_ac_phosph_N PF16656.3 T150991_3 - 0.011 16.2 0.1 0.027 14.9 0.1 1.6 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Ank_5 PF13857.4 T150991_3 - 0.032 14.5 0.0 0.093 13.0 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) KRAB PF01352.25 T299541_2 - 5.5e-22 77.0 0.1 1.1e-21 76.0 0.1 1.6 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 T299541_3 - 1.9e-137 442.0 155.8 8.8e-09 35.3 0.3 21.6 21 0 0 21 21 21 18 Zinc-finger double domain zf-C2H2 PF00096.24 T299541_3 - 1e-97 315.4 169.2 9e-06 25.7 1.9 20.2 20 0 0 20 20 20 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T299541_3 - 6.5e-45 147.8 158.1 0.0091 16.6 0.7 20.9 20 0 0 20 20 20 19 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T299541_3 - 2.9e-36 122.6 133.8 4.5e-05 23.2 0.9 20.3 20 0 0 20 20 20 18 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T299541_3 - 1.1e-06 28.5 121.8 0.025 14.6 3.0 12.6 3 1 16 19 19 19 17 Zinc ribbon domain zf-C2H2_11 PF16622.3 T299541_3 - 0.092 12.4 106.5 0.23 11.1 1.0 18.1 20 0 0 20 20 20 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 T299541_3 - 0.24 12.0 99.5 0.68 10.6 2.8 10.7 2 2 12 14 14 14 0 zinc-ribbon family XPA_N PF01286.16 T299541_3 - 0.44 10.5 102.0 3.5 7.6 0.2 19.2 19 0 0 19 19 19 0 XPA protein N-terminal Treacle PF03546.12 T291373_1 - 5.8e-232 771.1 247.0 1.2e-170 568.8 121.7 8.2 3 2 5 8 8 8 4 Treacher Collins syndrome protein Treacle Gal-3-0_sulfotr PF06990.9 T291373_1 - 0.036 12.8 0.1 0.059 12.1 0.1 1.2 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase UPF0029 PF01205.17 T159945_1 - 6.6e-34 116.3 0.0 9.9e-34 115.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.20 T159945_1 - 1.1e-17 64.3 0.3 1.9e-17 63.5 0.3 1.4 1 0 0 1 1 1 1 RWD domain BTB PF00651.29 T056939_1 - 5e-24 84.5 1.0 1.1e-23 83.5 1.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ank_2 PF12796.5 T056939_1 - 2.2e-17 63.3 0.0 2.9e-10 40.5 0.0 3.3 2 1 2 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T056939_1 - 5.5e-14 50.8 1.0 0.00013 21.9 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.4 T056939_1 - 6.9e-13 48.7 2.3 9.3e-09 35.5 0.0 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.28 T056939_1 - 2.2e-11 43.6 4.0 3.1e-05 24.1 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.4 T056939_1 - 6.5e-11 42.2 2.0 0.001 19.3 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) BACK PF07707.13 T056939_1 - 0.11 12.5 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 BTB And C-terminal Kelch zf-RING_2 PF13639.4 T365005_2 - 1.5e-09 37.8 12.8 1.5e-09 37.8 12.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 T365005_2 - 8.8e-06 25.5 10.3 2.5e-05 24.0 10.3 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 T365005_2 - 0.00022 21.0 11.2 0.00029 20.7 9.5 2.3 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 T365005_2 - 0.0049 16.9 11.5 0.0049 16.9 11.5 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 T365005_2 - 0.012 15.3 11.5 0.032 14.0 11.5 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T365005_2 - 0.091 12.5 12.7 0.24 11.1 12.7 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.4 T365005_2 - 0.37 10.4 8.0 1 9.0 8.0 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Frag1 PF10277.7 T053637_2 - 4.3e-24 85.1 6.4 4.3e-24 85.1 6.4 1.4 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family Frag1 PF10277.7 T053637_3 - 5.3e-14 52.2 0.6 7.7e-14 51.6 0.6 1.2 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Na_trans_cytopl PF11933.6 T053637_3 - 0.12 12.1 0.3 0.21 11.3 0.3 1.3 1 0 0 1 1 1 0 Cytoplasmic domain of voltage-gated Na+ ion channel RasGEF PF00617.17 T060839_3 - 3.5e-40 137.9 0.0 7.1e-40 136.9 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 T060839_3 - 3.2e-11 42.8 7.9 6.5e-11 41.8 7.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.30 T060839_3 - 5.1e-11 41.2 0.8 2e-05 23.7 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T060839_3 - 3.2e-10 39.0 0.2 8.1e-05 22.1 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.4 T060839_3 - 1.1e-09 38.5 4.6 4.4e-07 30.2 1.0 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 T060839_3 - 1.1e-09 37.2 0.7 1.1e-05 24.6 0.2 2.7 2 0 0 2 2 2 2 EF hand RasGEF_N PF00618.18 T060839_3 - 8.6e-09 35.5 0.2 3.8e-07 30.2 0.0 2.7 3 0 0 3 3 3 1 RasGEF N-terminal motif EF-hand_8 PF13833.4 T060839_3 - 0.00012 21.6 1.8 0.0047 16.5 0.3 2.4 2 0 0 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.7 T060839_3 - 0.13 12.5 0.1 3 8.0 0.1 2.4 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region zf-CCHC PF00098.21 T137874_1 - 2.2e-06 27.3 2.0 9.2e-06 25.4 2.0 2.2 1 0 0 1 1 1 1 Zinc knuckle SAM_1 PF00536.28 T137874_1 - 0.00064 20.0 0.5 0.0013 19.0 0.5 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T137874_1 - 0.088 12.8 0.3 0.16 11.9 0.3 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) I-set PF07679.14 T069545_1 - 4.1e-82 270.2 0.0 2.2e-17 62.7 0.0 6.2 6 1 0 6 6 6 5 Immunoglobulin I-set domain Ig_3 PF13927.4 T069545_1 - 1.1e-77 256.5 0.0 9.1e-15 54.9 0.0 6.1 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 T069545_1 - 2.7e-52 174.8 0.0 1.4e-11 44.2 0.1 6.0 5 1 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 T069545_1 - 2e-49 165.7 0.0 2.6e-09 37.2 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.19 T069545_1 - 4.2e-31 107.0 2.5 3.1e-12 46.5 0.4 3.6 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.15 T069545_1 - 2.7e-29 101.4 1.1 1.7e-06 28.0 0.0 8.6 6 2 0 6 6 6 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 T069545_1 - 8e-15 54.6 5.5 0.071 13.1 0.1 6.1 6 0 0 6 6 6 5 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 T069545_1 - 5.5e-10 39.4 0.0 0.015 15.6 0.0 5.4 5 1 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pur_ac_phosph_N PF16656.3 T069545_1 - 1.8e-07 31.5 0.0 0.011 16.2 0.1 3.7 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain C1-set PF07654.13 T069545_1 - 0.00018 21.8 0.0 4.2 7.8 0.0 5.3 6 0 0 6 6 6 1 Immunoglobulin C1-set domain Herpes_gE PF02480.14 T069545_1 - 0.07 11.7 0.0 3.5 6.1 0.0 2.7 3 0 0 3 3 3 0 Alphaherpesvirus glycoprotein E RPAP2_Rtr1 PF04181.11 T015153_1 - 1.9e-22 79.2 0.4 5.3e-22 77.8 0.4 1.8 1 0 0 1 1 1 1 Rtr1/RPAP2 family RVT_1 PF00078.25 T015153_1 - 1.1e-20 73.9 1.1 1.9e-20 73.2 1.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T015153_1 - 0.0077 15.7 2.4 0.012 15.1 0.3 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T015153_2 - 1.1e-17 64.2 0.0 2.8e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.4 T015153_2 - 0.0021 17.8 0.5 0.0038 16.9 0.5 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T015153_2 - 0.023 14.8 0.0 0.042 14.0 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T015153_3 - 9.1e-117 389.9 20.2 1.6e-116 389.1 20.2 1.3 1 0 0 1 1 1 1 L1 transposable element Syntaxin-6_N PF09177.9 T015153_3 - 0.16 12.4 7.2 0.34 11.4 7.2 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal PNMA PF14893.4 T382042_3 - 9.6e-132 439.2 0.7 1.3e-131 438.8 0.7 1.2 1 0 0 1 1 1 1 PNMA zf-CCHC PF00098.21 T382042_3 - 0.013 15.4 2.8 0.059 13.4 2.8 2.2 1 0 0 1 1 1 0 Zinc knuckle KRAB PF01352.25 T335557_3 - 4.2e-30 103.0 3.1 5.3e-21 73.9 0.3 2.5 2 0 0 2 2 2 2 KRAB box Dimer_Tnp_hAT PF05699.12 T335557_3 - 4.5e-07 29.4 0.2 9.5e-07 28.4 0.2 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4371 PF14291.4 T335557_3 - 0.037 13.6 0.0 0.07 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) zf-H2C2_2 PF13465.4 T354472_1 - 3.7e-106 343.1 103.8 9.3e-08 32.1 0.2 18.2 18 0 0 18 18 18 16 Zinc-finger double domain zf-C2H2 PF00096.24 T354472_1 - 1.2e-83 271.0 117.3 4.1e-06 26.8 0.4 18.0 17 0 0 17 17 17 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T354472_1 - 3.6e-33 111.2 122.4 0.019 15.6 0.4 18.3 18 0 0 18 18 18 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T354472_1 - 1.6e-16 59.7 98.4 0.012 15.4 1.0 16.7 17 0 0 17 17 17 12 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T354472_1 - 7.4e-14 51.5 68.8 0.014 15.3 1.8 10.4 5 2 5 11 11 11 10 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T354472_1 - 0.00092 19.3 66.5 1.8 8.8 0.1 16.0 17 0 0 17 17 17 4 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T354472_1 - 0.0028 18.2 61.5 2.7 8.7 4.4 8.5 1 1 7 9 9 9 5 zinc-ribbon family XPA_N PF01286.16 T354472_1 - 0.047 13.6 60.7 20 5.2 0.2 16.0 17 0 0 17 17 17 0 XPA protein N-terminal zf-H2C2_2 PF13465.4 T354472_2 - 1.1e-90 294.2 84.9 5.7e-08 32.7 0.8 14.5 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 T354472_2 - 1.8e-54 179.1 95.8 0.00034 20.8 2.1 14.1 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T354472_2 - 5.9e-22 76.3 95.3 0.024 15.3 0.3 14.5 13 0 0 13 13 13 12 C2H2-type zinc finger KRAB PF01352.25 T354472_2 - 1.9e-18 65.7 0.1 3.7e-18 64.8 0.1 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 T354472_2 - 1e-07 31.8 51.3 0.15 12.1 1.4 8.0 4 2 3 8 8 8 7 Zinc ribbon domain zf-C2H2_6 PF13912.4 T354472_2 - 1.4e-06 27.9 62.6 0.25 11.2 0.2 11.9 12 0 0 12 12 12 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T354472_2 - 0.02 15.1 41.4 0.33 11.2 0.1 10.8 12 0 0 12 12 12 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T354472_2 - 0.67 10.6 39.0 5.2 7.7 0.5 6.7 1 1 6 8 8 8 0 zinc-ribbon family COMM_domain PF07258.12 T354472_3 - 3.8e-14 52.4 0.0 8.2e-14 51.4 0.0 1.6 1 0 0 1 1 1 1 COMM domain DUF4200 PF13863.4 T249756_1 - 1.5e-32 112.3 15.0 2.5e-32 111.6 15.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) Ephrin PF00812.15 T021852_2 - 1.3e-39 135.2 0.1 2.1e-39 134.5 0.1 1.3 1 0 0 1 1 1 1 Ephrin IncA PF04156.12 T232369_2 - 5.8 6.5 13.5 0.042 13.5 2.3 3.1 3 0 0 3 3 3 0 IncA protein RRM_1 PF00076.20 T191399_1 - 2.4e-31 107.2 0.3 8.6e-17 60.6 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 T191399_1 - 3.8e-05 23.3 0.0 7.5e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_1 PF00076.20 T191399_2 - 1.2e-27 95.4 0.0 8e-21 73.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T191399_2 - 0.0066 16.4 0.0 0.64 10.0 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.3 T191399_2 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif zf-A20 PF01754.14 T360282_2 - 5e-11 42.2 8.8 5e-11 42.2 8.8 3.1 3 0 0 3 3 3 1 A20-like zinc finger zf-AN1 PF01428.14 T360282_2 - 2.7e-08 33.7 8.2 2.7e-08 33.7 8.2 3.2 3 0 0 3 3 3 1 AN1-like Zinc finger BACK PF07707.13 T289619_1 - 6.4e-36 122.4 0.7 1.3e-35 121.5 0.7 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 T289619_1 - 1.9e-11 44.0 0.1 4.1e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.23 T289619_3 - 9.6e-28 95.4 3.4 1.1e-14 53.6 0.6 2.7 2 0 0 2 2 2 2 Kelch motif BTB PF00651.29 T289619_3 - 4.7e-13 49.2 0.1 4.7e-13 49.2 0.1 1.9 3 0 0 3 3 3 1 BTB/POZ domain Kelch_6 PF13964.4 T289619_3 - 8.3e-12 44.8 0.2 0.00011 22.3 0.1 2.6 1 1 1 2 2 2 2 Kelch motif Kelch_3 PF13415.4 T289619_3 - 2.2e-11 43.6 1.5 1.9e-05 24.7 0.0 2.7 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.13 T289619_3 - 4.5e-09 35.8 0.2 0.00032 20.4 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.4 T289619_3 - 1.7e-05 24.5 0.3 0.27 11.1 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Ank_2 PF12796.5 T000878_1 - 6e-39 132.4 11.1 4.1e-16 59.2 0.1 6.3 3 1 3 7 7 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T000878_1 - 4e-35 119.2 16.2 2.9e-08 33.7 0.1 7.6 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_4 PF13637.4 T000878_1 - 1.1e-33 115.0 3.8 2.6e-09 37.3 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 T000878_1 - 9.3e-25 85.8 16.3 1.4e-05 25.2 0.0 9.8 9 0 0 9 9 9 5 Ankyrin repeat Ank_3 PF13606.4 T000878_1 - 3.4e-23 79.1 8.9 0.00093 19.4 0.1 9.1 10 0 0 10 10 9 5 Ankyrin repeat MIB_HERC2 PF06701.11 T000878_1 - 1.6e-22 79.4 9.3 1.6e-22 79.4 9.3 2.4 2 0 0 2 2 2 1 Mib_herc2 zf-C3HC4_3 PF13920.4 T000878_1 - 1.6e-09 37.4 26.0 1.3e-06 28.0 8.4 4.1 3 0 0 3 3 2 2 Zinc finger, C3HC4 type (RING finger) Peptidase_M10 PF00413.22 T000878_1 - 2.8e-09 36.9 0.3 4.8e-09 36.1 0.3 1.3 1 0 0 1 1 1 1 Matrixin ZZ PF00569.15 T000878_1 - 2.2e-07 30.4 10.4 2.2e-07 30.4 10.4 2.7 2 0 0 2 2 2 1 Zinc finger, ZZ type ShK PF01549.22 T000878_1 - 1.2e-05 25.6 5.0 1.2e-05 25.6 5.0 2.3 2 0 0 2 2 1 1 ShK domain-like Ig_2 PF13895.4 T000878_1 - 4.8e-05 23.5 0.1 0.00011 22.3 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Reprolysin_4 PF13583.4 T000878_1 - 0.02 14.4 3.1 0.033 13.7 3.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.4 T000878_1 - 0.082 13.3 0.6 0.16 12.4 0.6 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 T000878_1 - 0.086 11.9 2.4 0.13 11.3 2.4 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M57 PF12388.6 T000878_1 - 0.29 10.6 1.0 0.64 9.5 1.0 1.5 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Astacin PF01400.22 T000878_1 - 0.39 10.2 1.8 0.78 9.2 1.8 1.4 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.22 T000878_2 - 1.7e-19 70.1 0.0 2.7e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Matrixin Hydrolase PF00702.24 T324600_3 - 7.7e-16 58.9 0.0 1.1e-15 58.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 T324600_3 - 3.9e-11 43.6 0.0 7.2e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.10 T324600_3 - 0.00011 21.6 0.0 0.00018 21.0 0.0 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD_2 PF13419.4 T324600_3 - 0.0011 19.0 0.0 0.16 11.9 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.10 T324600_3 - 0.0034 16.7 0.0 0.0075 15.6 0.0 1.5 1 1 0 1 1 1 1 Putative Phosphatase StbA PF06406.9 T324600_3 - 0.15 11.1 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 StbA protein COesterase PF00135.26 T370949_3 - 1.4e-198 660.9 0.0 1.7e-198 660.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 T370949_3 - 7.2e-07 29.1 0.1 2.3e-06 27.5 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold C1-set PF07654.13 T300274_1 - 3.3e-14 53.0 0.0 6.5e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 T300274_1 - 3.8e-14 52.2 8.5 6.9e-14 51.3 8.5 1.5 1 0 0 1 1 1 1 MHC_I C-terminus DEAD PF00270.27 T152172_2 - 3.5e-49 166.8 0.0 3.8e-48 163.4 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T152172_2 - 1e-27 96.5 0.0 4.3e-27 94.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 T152172_2 - 1.9e-06 27.8 0.0 3.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 T152172_2 - 0.011 14.8 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase BPS PF08947.8 T323921_2 - 1.9e-28 97.9 0.7 3.7e-28 96.9 0.7 1.5 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 T323921_2 - 2.1e-13 50.0 0.0 3.8e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 T323921_2 - 2.1e-10 41.0 0.2 4.5e-10 39.9 0.2 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 T323921_2 - 4.2e-09 36.7 0.9 6.7e-09 36.1 0.1 1.8 2 0 0 2 2 2 1 PH domain 7tm_1 PF00001.19 T305504_3 - 7.1e-56 189.2 21.6 1e-55 188.8 21.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Orexin_rec2 PF03827.11 T305504_3 - 3.9e-34 116.3 1.4 6.7e-34 115.5 1.4 1.4 1 0 0 1 1 1 1 Orexin receptor type 2 SNARE PF05739.17 T305504_3 - 1.5 8.8 7.6 0.45 10.4 0.1 2.6 2 0 0 2 2 2 0 SNARE domain EF-hand_7 PF13499.4 T034448_1 - 1.7e-05 25.1 0.1 3.4e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.4 T034448_1 - 0.00086 19.5 0.0 0.0094 16.1 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_6 PF13405.4 T034448_1 - 0.052 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain V-set PF07686.15 T193753_3 - 7.7e-16 58.1 0.0 1.1e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T193753_3 - 7.4e-08 32.8 0.0 1.3e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T193753_3 - 1.2e-05 25.2 0.0 2.1e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T193753_3 - 6.3e-05 22.8 0.0 0.0001 22.2 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Glyco_hydro_20 PF00728.20 T157027_1 - 2.5e-08 33.6 0.0 3.9e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain TSNAXIP1_N PF15739.3 T189616_1 - 8.3e-17 61.4 0.5 8.3e-17 61.4 0.5 1.7 2 0 0 2 2 2 1 Translin-associated factor X-interacting N-terminus Clathrin_H_link PF13838.4 T189616_3 - 3.6e-12 45.9 0.0 8.3e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 Clathrin-H-link Kelch_1 PF01344.23 T350665_2 - 1.6e-33 113.9 0.1 1.1e-08 34.4 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 T350665_2 - 2.9e-31 106.6 0.7 1.8e-05 24.7 0.0 6.9 3 2 3 6 6 6 6 Kelch motif BTB PF00651.29 T350665_2 - 1.3e-25 89.6 0.0 2.2e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 T350665_2 - 3.1e-24 84.9 1.0 7.9e-24 83.6 0.3 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 T350665_2 - 4.2e-21 74.6 0.0 0.0014 18.8 0.1 7.0 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.4 T350665_2 - 2.1e-15 56.3 2.1 0.012 15.4 0.0 6.7 6 1 1 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.13 T350665_2 - 4.8e-15 54.7 0.1 0.002 17.9 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.4 T350665_2 - 2.6e-07 30.4 1.2 0.47 10.4 0.0 5.6 6 0 0 6 6 6 2 Kelch motif DUF3342 PF11822.6 T350665_2 - 0.01 15.9 0.1 0.038 14.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Acetyltransf_3 PF13302.5 T154093_1 - 6.5e-17 62.4 0.0 9.7e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 T154093_1 - 0.01 15.9 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family PDEase_I PF00233.17 T315106_2 - 1.6e-71 240.7 1.8 3.7e-71 239.5 0.4 2.0 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 T315106_2 - 2.7e-27 95.7 0.0 4.2e-18 66.0 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.4 T315106_2 - 1.6e-15 57.5 0.0 9.3e-08 32.3 0.0 2.2 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.4 T315106_2 - 3.5e-09 36.9 0.0 1.2e-05 25.5 0.0 2.3 2 0 0 2 2 2 2 GAF domain SpoVT_C PF15714.3 T315106_2 - 0.0004 20.3 0.0 0.012 15.5 0.0 2.3 2 0 0 2 2 2 1 Stage V sporulation protein T C-terminal, transcription factor HD PF01966.20 T315106_2 - 0.081 13.0 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 HD domain DUF1899 PF08953.9 T085948_2 - 2.3e-31 107.3 0.0 4.4e-31 106.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 T085948_2 - 2.2e-21 75.3 0.1 4.1e-21 74.4 0.1 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 T085948_2 - 2.9e-11 43.6 14.1 0.00015 22.4 0.6 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T085948_2 - 3.4e-05 23.9 0.3 0.062 13.5 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 T085948_2 - 0.042 13.6 0.0 0.075 12.8 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A EVI2A PF05399.9 T085948_3 - 0.0032 17.0 5.2 0.0032 17.0 5.2 2.3 1 1 1 2 2 2 1 Ectropic viral integration site 2A protein (EVI2A) TFIIA PF03153.11 T085948_3 - 6.6 6.5 19.9 9.6 5.9 19.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DEC-1_N PF04625.11 T156121_1 - 1.5 7.6 4.0 2.9 6.7 4.0 1.4 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Sulfate_transp PF00916.18 T156121_2 - 3.1e-94 315.7 14.7 3.9e-94 315.4 14.7 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 T156121_2 - 9.6e-11 41.2 0.0 1.4e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.4 T156121_2 - 0.0081 16.3 0.5 0.036 14.3 0.5 2.2 1 0 0 1 1 1 1 STAS domain adh_short PF00106.23 T106228_1 - 6.1e-36 123.6 0.2 1.7e-35 122.1 0.2 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 T106228_1 - 1.1e-21 77.3 0.0 1.8e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase V-SNARE_C PF12352.6 T106228_1 - 2.2e-19 69.4 8.0 2.2e-19 69.4 8.0 1.7 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.13 T106228_1 - 2.9e-15 56.3 4.4 7e-15 55.0 4.4 1.7 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus KR PF08659.8 T106228_1 - 1.3e-07 31.6 0.1 2.3e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 KR domain Sec20 PF03908.11 T106228_1 - 0.0001 22.0 1.4 0.00026 20.7 1.4 1.7 1 0 0 1 1 1 1 Sec20 Fusion_gly PF00523.16 T106228_1 - 0.084 11.0 0.4 0.12 10.4 0.4 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 DUF3376 PF11856.6 T106228_1 - 0.1 11.4 1.0 0.16 10.8 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3376) NAD_binding_10 PF13460.4 T106228_1 - 0.1 12.3 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding YqjK PF13997.4 T106228_1 - 0.28 11.3 1.3 28 4.9 0.4 2.4 2 0 0 2 2 2 0 YqjK-like protein Alpha-amylase PF00128.22 T188644_2 - 5.4e-21 75.4 0.1 8.1e-21 74.8 0.1 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Syndecan PF01034.18 T078598_2 - 0.037 13.8 0.3 0.074 12.8 0.3 1.4 1 0 0 1 1 1 0 Syndecan domain OAD_gamma PF04277.11 T078598_2 - 0.096 13.2 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain HTH_Tnp_Tc5 PF03221.14 T297374_1 - 1e-12 47.8 0.0 1.7e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain BrkDBD PF09607.8 T297374_1 - 0.44 10.2 2.5 0.24 11.1 0.3 1.6 2 0 0 2 2 2 0 Brinker DNA-binding domain DUF4750 PF15938.3 T297374_2 - 1.6e-18 66.0 8.0 3.4e-18 64.9 8.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4750) HRM PF02793.20 T303016_3 - 5.1e-09 36.2 1.3 5.1e-09 36.2 1.3 2.3 2 0 0 2 2 2 1 Hormone receptor domain ubiquitin PF00240.21 T142543_2 - 1.5e-33 114.2 0.3 2.3e-33 113.6 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 T142543_2 - 1.3e-15 56.8 0.4 1.8e-15 56.3 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 T142543_2 - 6.4e-05 23.2 0.1 0.00012 22.3 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 T142543_2 - 0.15 12.1 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like IL8 PF00048.18 T145986_1 - 1.5e-19 69.8 2.3 2.9e-19 68.8 2.3 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.18 T145986_3 - 6.1e-42 141.5 7.8 2.5e-22 78.7 1.2 2.5 2 0 0 2 2 2 2 Small cytokines (intecrine/chemokine), interleukin-8 like C2-set_2 PF08205.10 T177018_1 - 7.2e-20 70.7 0.2 7.2e-20 70.7 0.2 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 T177018_1 - 8.4e-11 42.2 2.4 0.0067 16.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T177018_1 - 1.5e-09 37.7 0.0 0.017 15.1 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T177018_1 - 3e-09 36.9 0.0 1.6e-08 34.6 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T177018_1 - 0.0026 17.9 0.6 3.4 8.0 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.14 T177018_1 - 0.0039 17.1 0.0 2 8.4 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin I-set domain V-set PF07686.15 T177018_3 - 1.8e-06 27.9 0.0 3.7e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Syntaphilin PF15290.4 T349506_3 - 1.1e-138 462.0 0.8 1.1e-138 462.0 0.8 1.9 2 0 0 2 2 1 1 Golgi-localised syntaxin-1-binding clamp Fez1 PF06818.13 T349506_3 - 0.00014 22.2 7.1 0.00027 21.3 7.1 1.3 1 0 0 1 1 1 1 Fez1 FAM76 PF16046.3 T349506_3 - 0.0009 18.6 5.6 0.0009 18.6 5.6 1.9 2 1 1 3 3 3 2 FAM76 protein PKcGMP_CC PF16808.3 T349506_3 - 0.0089 15.7 5.8 0.0089 15.7 5.8 3.3 4 1 0 4 4 3 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Exonuc_VII_L PF02601.13 T349506_3 - 0.03 13.8 1.6 0.046 13.1 1.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FPP PF05911.9 T349506_3 - 0.082 11.0 11.8 0.12 10.4 11.8 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil IncA PF04156.12 T349506_3 - 0.13 11.9 8.4 0.28 10.8 8.4 1.5 1 0 0 1 1 1 0 IncA protein Atg14 PF10186.7 T349506_3 - 0.17 10.8 6.5 0.34 9.8 6.5 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BST2 PF16716.3 T349506_3 - 0.29 11.6 7.8 0.62 10.5 7.8 1.6 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 Sec8_exocyst PF04048.12 T349506_3 - 0.3 10.9 7.4 0.83 9.4 0.3 2.3 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Sec2p PF06428.9 T349506_3 - 0.3 10.9 12.7 0.12 12.2 2.5 2.6 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p HR1 PF02185.14 T349506_3 - 0.49 10.4 9.8 0.72 9.9 1.4 2.5 2 0 0 2 2 2 0 Hr1 repeat DUF342 PF03961.11 T349506_3 - 0.52 8.7 4.3 0.74 8.2 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Spc7 PF08317.9 T349506_3 - 1.4 7.6 11.9 2.2 7.0 11.1 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF745 PF05335.11 T349506_3 - 1.6 8.3 6.3 2.4 7.7 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Spc42p PF11544.6 T349506_3 - 1.7 8.6 7.1 0.44 10.4 1.1 2.4 2 0 0 2 2 2 0 Spindle pole body component Spc42p DUF16 PF01519.14 T349506_3 - 2.5 8.5 8.9 31 5.0 8.9 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 CC2-LZ PF16516.3 T349506_3 - 2.9 8.1 11.6 2.6 8.3 3.0 2.3 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator HMMR_N PF15905.3 T349506_3 - 3.8 6.8 17.4 0.013 14.8 8.2 1.5 2 0 0 2 2 1 0 Hyaluronan mediated motility receptor N-terminal CALCOCO1 PF07888.9 T349506_3 - 4.1 5.7 18.7 0.045 12.2 11.1 1.5 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TPR_MLP1_2 PF07926.10 T349506_3 - 5.4 7.0 13.6 1.4 8.9 6.6 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein GrpE PF01025.17 T349506_3 - 6.3 6.3 9.1 11 5.6 9.1 1.2 1 0 0 1 1 1 0 GrpE DcpS_C PF11969.6 T357240_3 - 5.8e-33 113.6 1.5 9.1e-33 113.0 1.5 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-C2HE PF16278.3 T357240_3 - 1.6e-13 50.7 0.1 4.4e-13 49.3 0.0 1.8 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger HIT PF01230.21 T357240_3 - 3.5e-13 50.0 0.9 5.9e-13 49.2 0.9 1.4 1 0 0 1 1 1 1 HIT domain SPRY PF00622.26 T242626_3 - 1.8e-26 92.5 0.1 3e-26 91.8 0.1 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.4 T242626_3 - 5.7e-10 38.8 8.4 1.4e-09 37.5 8.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T242626_3 - 0.00028 21.0 10.6 0.00073 19.6 10.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 T242626_3 - 0.0013 18.4 13.0 0.0032 17.2 13.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T242626_3 - 0.0024 17.6 11.9 0.0066 16.1 11.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T242626_3 - 0.039 13.8 12.2 0.099 12.5 12.2 1.8 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.4 T242626_3 - 0.076 12.7 14.6 0.021 14.5 10.1 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 FdhE PF04216.10 T242626_3 - 0.089 12.5 2.9 0.21 11.3 2.9 1.6 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation zf-C3HC4_4 PF15227.4 T242626_3 - 0.22 11.6 10.7 0.56 10.3 10.7 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 T242626_3 - 0.29 11.1 11.5 0.69 9.9 11.5 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_10 PF16685.3 T242626_3 - 1.5 8.9 8.1 0.54 10.3 5.0 1.8 2 0 0 2 2 1 0 zinc RING finger of MSL2 Ank_4 PF13637.4 T284917_1 - 1.5e-17 63.6 0.1 5.5e-06 26.7 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 T284917_1 - 1e-15 57.9 0.7 3.6e-10 40.1 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 T284917_1 - 1.2e-13 50.7 0.8 2e-05 24.7 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.4 T284917_1 - 1.4e-09 37.9 0.0 0.00011 22.3 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 T284917_1 - 3.3e-09 36.1 0.1 0.0014 18.8 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat zf-MIZ PF02891.18 T044773_3 - 1e-22 79.5 4.5 1e-22 79.5 4.5 2.8 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 T044773_3 - 1.8e-05 24.3 1.2 1.8e-05 24.3 1.2 2.2 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit CC190 PF15768.3 T024082_1 - 1e-108 363.4 10.1 1e-108 363.4 10.1 1.6 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 190 VPS9 PF02204.16 T241716_1 - 1.7e-19 69.8 0.0 5.5e-19 68.2 0.0 1.8 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain MORN PF02493.18 T241716_1 - 2.5e-06 26.9 1.5 9.2e-06 25.1 1.5 2.1 1 0 0 1 1 1 1 MORN repeat MORN PF02493.18 T241716_3 - 3.4e-10 39.1 27.0 0.0033 17.1 0.2 6.3 6 0 0 6 6 6 5 MORN repeat bZIP_1 PF00170.19 T061438_1 - 9.1e-07 28.8 16.2 1.4e-06 28.1 16.2 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 T061438_1 - 0.00015 21.6 14.8 0.00028 20.8 14.8 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 T061438_1 - 0.00024 21.4 12.1 0.00042 20.6 12.1 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF3450 PF11932.6 T061438_1 - 0.067 12.4 1.1 0.1 11.7 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Macoilin PF09726.7 T061438_1 - 0.55 8.6 7.7 0.77 8.1 7.7 1.1 1 0 0 1 1 1 0 Transmembrane protein APG6 PF04111.10 T061438_1 - 1.2 8.3 6.1 1.7 7.8 6.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Mnd1 PF03962.13 T061438_1 - 3.5 7.3 5.8 5.3 6.7 5.8 1.1 1 0 0 1 1 1 0 Mnd1 family LUC7 PF03194.13 T124065_1 - 9.2e-75 251.3 13.6 1.5e-74 250.7 13.6 1.3 1 0 0 1 1 1 1 LUC7 N_terminus Pkinase PF00069.23 T084527_1 - 1.5e-71 240.8 0.0 2e-71 240.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T084527_1 - 5e-34 117.6 0.0 8.5e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T084527_1 - 4.1e-05 22.9 0.0 6.3e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 T084527_1 - 0.0036 16.5 0.4 0.0061 15.8 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Meckelin PF09773.7 T347849_3 - 0 1147.0 8.1 0 1146.3 8.1 1.3 1 0 0 1 1 1 1 Meckelin (Transmembrane protein 67) Paralemmin PF03285.13 T364569_2 - 3.7e-19 69.3 3.5 3.7e-19 69.3 3.5 3.4 3 1 1 4 4 4 1 Paralemmin AKAP2_C PF15304.4 T364569_3 - 1.3e-06 27.9 0.2 2.7e-06 26.8 0.2 1.5 1 0 0 1 1 1 1 A-kinase anchor protein 2 C-terminus BAT2_N PF07001.9 T025107_3 - 6.1e-50 170.3 12.7 6.1e-50 170.3 12.7 11.8 12 3 0 13 13 13 1 BAT2 N-terminus NAM-associated PF14303.4 T025107_3 - 0.042 14.4 0.0 0.042 14.4 0.0 9.0 6 3 3 9 9 9 0 No apical meristem-associated C-terminal domain DUF4597 PF15366.4 T137456_2 - 1e-33 114.7 4.2 2e-33 113.8 4.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4597) Sld5 PF05916.9 T137456_2 - 1.4e-21 76.8 2.3 2.2e-21 76.2 2.3 1.3 1 0 0 1 1 1 1 GINS complex protein Glyco_hydro_18 PF00704.26 T028289_2 - 2.5e-103 345.9 1.4 2.9e-103 345.7 1.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF3915 PF13054.4 T361247_1 - 1.1 9.1 3.3 2.1 8.2 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Nucleos_tra2_C PF07662.11 T361247_2 - 2.8e-77 259.2 6.8 4e-77 258.7 6.8 1.2 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.18 T361247_3 - 2e-23 82.6 1.0 2e-23 82.6 1.0 2.5 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.12 T361247_3 - 0.00024 21.2 1.4 0.00055 20.1 1.4 1.6 1 0 0 1 1 1 1 Nucleoside recognition DUF3915 PF13054.4 T361247_3 - 0.028 14.3 2.9 0.07 13.0 2.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 T361247_3 - 0.047 11.9 5.1 0.077 11.1 5.1 1.2 1 0 0 1 1 1 0 Atrophin-1 family Peptidase_M16 PF00675.18 T369159_1 - 5.9e-39 133.3 0.0 9e-39 132.7 0.0 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) DUF2695 PF10905.6 T369159_1 - 0.052 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2695) Peptidase_M16_C PF05193.19 T369159_2 - 3.6e-41 141.0 0.0 5.5e-41 140.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain 7tm_4 PF13853.4 T035024_2 - 2.2e-47 162.0 21.5 3.2e-47 161.4 21.5 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T035024_2 - 7.4e-22 77.7 19.3 1.3e-21 77.0 19.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Not1 PF04054.13 T133466_1 - 6.6e-154 512.1 6.6 1.3e-153 511.1 6.6 1.5 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.3 T133466_1 - 8.6e-96 319.5 14.5 1.8e-95 318.5 9.5 3.0 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.3 T133466_1 - 1.6e-84 281.7 0.2 3.6e-84 280.5 0.2 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.5 T133466_1 - 5.3e-54 182.0 7.8 5.3e-54 182.0 7.8 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.3 T133466_1 - 5.6e-54 182.1 0.0 1.3e-53 180.9 0.0 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat PTS_2-RNA PF01885.14 T060567_2 - 5.1e-53 179.7 0.0 6.3e-53 179.4 0.0 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family FIIND PF13553.4 T140369_1 - 2.1e-102 341.7 0.1 1.1e-101 339.3 0.0 2.0 2 0 0 2 2 2 1 Function to find NACHT PF05729.10 T140369_1 - 1.4e-46 158.3 0.1 9e-46 155.7 0.0 2.2 2 0 0 2 2 2 1 NACHT domain PYRIN PF02758.14 T140369_1 - 1.8e-16 60.0 0.1 4.3e-16 58.7 0.1 1.7 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain LRR_6 PF13516.4 T140369_1 - 9.7e-15 53.2 14.7 4.3e-06 26.2 0.2 5.6 5 0 0 5 5 5 3 Leucine Rich repeat AAA_16 PF13191.4 T140369_1 - 7.2e-07 29.6 0.0 9.4e-06 26.0 0.0 2.7 1 1 0 1 1 1 1 AAA ATPase domain LRR_4 PF12799.5 T140369_1 - 4.4e-05 23.6 8.8 1.6 9.1 0.3 4.6 2 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T140369_1 - 0.0012 18.5 3.6 3.2 7.4 0.1 3.6 3 0 0 3 3 3 2 Leucine rich repeat NB-ARC PF00931.20 T140369_1 - 0.0065 15.4 0.0 0.013 14.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain LRR_1 PF00560.31 T140369_1 - 0.0072 16.5 9.5 1.1 9.9 0.2 5.4 5 1 0 5 5 4 1 Leucine Rich Repeat AAA_30 PF13604.4 T140369_1 - 0.0097 15.5 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 T140369_1 - 0.066 13.4 0.1 0.32 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 T140369_1 - 0.088 12.0 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_5 PF07728.12 T140369_1 - 0.09 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Herpes_U30 PF04523.11 T140369_1 - 0.14 9.9 0.9 0.24 9.1 0.3 1.6 1 1 1 2 2 2 0 Herpes virus tegument protein U30 Birna_VP5 PF03042.12 T140369_1 - 1 9.2 7.0 0.049 13.5 0.4 2.2 2 0 0 2 2 1 0 Birnavirus VP5 protein IL17R_fnIII_D1 PF16556.3 T243748_1 - 2.6e-16 59.5 0.0 4.3e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Interleukin-17 receptor, fibronectin-III-like domain 1 IL17R_fnIII_D2 PF16578.3 T243748_1 - 0.0043 17.4 0.0 0.0081 16.5 0.0 1.4 1 0 0 1 1 1 1 Interleukin 17 receptor D SEFIR PF08357.9 T243748_2 - 1.9e-48 164.4 0.7 2.8e-48 163.9 0.7 1.2 1 0 0 1 1 1 1 SEFIR domain IL17R_fnIII_D2 PF16578.3 T243748_3 - 0.017 15.5 0.4 0.046 14.1 0.4 1.7 1 0 0 1 1 1 0 Interleukin 17 receptor D TROVE PF05731.9 T100355_1 - 1.6e-133 445.4 1.6 2e-133 445.1 1.6 1.1 1 0 0 1 1 1 1 TROVE domain TEP1_N PF05386.9 T100355_1 - 9.7e-77 252.0 22.4 5.4e-20 70.5 1.0 4.6 4 0 0 4 4 4 4 TEP1 N-terminal domain NACHT PF05729.10 T100355_1 - 2e-36 125.3 0.1 4.4e-36 124.2 0.1 1.6 1 0 0 1 1 1 1 NACHT domain DUF4062 PF13271.4 T100355_1 - 2.2e-18 66.3 0.0 4.5e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) AAA_22 PF13401.4 T100355_1 - 6.5e-05 23.1 0.0 0.00015 21.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 T100355_1 - 6.9e-05 23.1 0.3 0.00022 21.5 0.3 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.4 T100355_1 - 0.03 13.7 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 T100355_1 - 0.14 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 T100355_1 - 0.14 11.8 0.1 0.28 10.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.4 T100355_1 - 0.19 12.0 0.0 0.33 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain WD40 PF00400.30 T100355_2 - 2.5e-35 119.8 32.1 8.5e-06 26.3 0.2 15.3 15 0 0 15 15 15 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T100355_2 - 4.2e-13 49.3 0.0 0.37 11.0 0.0 7.1 5 2 2 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T100355_2 - 1.5e-05 24.0 0.0 1.5 7.6 0.0 4.9 4 1 1 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.3 T100355_2 - 5.7e-05 22.5 0.0 0.0079 15.4 0.0 2.7 3 0 0 3 3 3 1 WD40-like domain Nup160 PF11715.6 T100355_2 - 0.0019 16.8 0.4 0.41 9.1 0.0 2.4 3 0 0 3 3 3 2 Nucleoporin Nup120/160 PQQ_3 PF13570.4 T100355_2 - 0.042 14.2 4.3 2.9 8.3 0.2 4.0 4 0 0 4 4 4 0 PQQ-like domain WD40 PF00400.30 T100355_3 - 0.053 14.3 0.1 5.8 7.8 0.0 3.5 3 0 0 3 3 3 0 WD domain, G-beta repeat SMI1_KNR4 PF09346.8 T160945_2 - 0.029 14.6 0.0 0.045 14.0 0.0 1.2 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) DUF4554 PF15091.4 T061803_2 - 4.8e-264 876.2 0.5 6.3e-264 875.8 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4554) Abi PF02517.14 T061803_3 - 6.6e-15 55.2 3.7 1.4e-14 54.1 3.7 1.5 1 0 0 1 1 1 1 CAAX protease self-immunity FSA_C PF10479.7 T270705_1 - 3.7e-65 220.3 4.2 4.7e-34 117.5 0.5 2.0 1 1 1 2 2 2 2 Fragile site-associated protein C-terminus FSA_C PF10479.7 T270705_2 - 9.4e-92 308.2 3.2 3e-91 306.5 3.2 1.7 1 1 0 1 1 1 1 Fragile site-associated protein C-terminus Homeobox PF00046.27 T010313_2 - 2.6e-21 75.1 3.6 4.6e-21 74.3 3.6 1.4 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 T010313_2 - 5.9e-05 22.6 1.2 0.00013 21.6 1.2 1.6 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 T010313_2 - 0.08 12.7 0.1 0.21 11.4 0.1 1.7 1 0 0 1 1 1 0 Homeobox KN domain ASH PF15780.3 T159108_2 - 3.6e-17 62.3 0.0 0.00019 21.4 0.0 6.2 7 1 0 7 7 7 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin MYCBPAP PF14646.4 T159108_2 - 2.8e-09 36.3 0.0 0.00029 19.8 0.0 4.1 4 0 0 4 4 4 3 MYCBP-associated protein family TMEM131_like PF12371.6 T159108_2 - 4.1e-07 29.9 1.0 2.5 8.2 0.1 5.6 5 1 0 5 5 5 3 Transmembrane protein 131-like Motile_Sperm PF00635.24 T159108_2 - 0.06 13.1 1.3 7.7 6.3 0.0 4.2 5 0 0 5 5 5 0 MSP (Major sperm protein) domain DUF4523 PF15023.4 T296328_3 - 3.6e-06 26.8 0.3 5.3e-06 26.2 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4523) Rpp20 PF12328.6 T329809_3 - 2.9e-19 69.2 0.0 1.7e-17 63.5 0.0 2.2 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.19 T329809_3 - 7.5e-09 35.2 0.0 1.1e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Alba RVT_1 PF00078.25 T171511_1 - 9.1e-10 38.3 0.0 1.5e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T171511_2 - 4.3e-07 29.3 0.3 8e-07 28.4 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Neur_chan_LBD PF02931.21 T273447_2 - 1.5e-52 178.1 0.1 1.9e-52 177.7 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 T273447_2 - 5.8e-07 29.7 0.2 1.1e-06 28.7 0.2 1.5 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_memb PF02932.14 T273447_3 - 0.0003 20.8 0.0 0.00046 20.2 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Glyco_transf_29 PF00777.16 T009506_3 - 1.7e-67 227.5 0.0 2.4e-67 227.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) JmjC PF02373.20 T009506_3 - 9.7e-42 141.9 0.1 2e-41 140.9 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.4 T009506_3 - 3.6e-32 110.6 8.2 3.6e-32 110.6 8.2 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 T009506_3 - 2.4e-14 53.2 5.3 2.4e-14 53.2 5.3 2.9 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.4 T009506_3 - 7.2e-14 50.9 4.7 7.2e-14 50.9 4.7 3.7 4 0 0 4 4 4 1 PHD-finger JmjN PF02375.15 T009506_3 - 1.9e-13 50.0 0.0 3.9e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 jmjN domain TGF_beta PF00019.18 T009506_3 - 1.3e-10 42.0 0.0 4.1e-10 40.3 0.0 2.0 1 0 0 1 1 1 1 Transforming growth factor beta like domain PHD PF00628.27 T009506_3 - 7.4e-06 25.6 1.4 7.4e-06 25.6 1.4 4.7 5 0 0 5 5 5 2 PHD-finger LBR_tudor PF09465.8 T009506_3 - 0.0016 18.1 1.2 0.071 12.8 0.2 2.5 2 0 0 2 2 2 1 Lamin-B receptor of TUDOR domain VWA_3 PF13768.4 T128761_1 - 1.7e-17 63.6 0.0 1.2e-14 54.4 0.1 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA PF00092.26 T128761_1 - 4.9e-08 33.3 0.0 9.4e-07 29.1 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.4 T128761_1 - 1.2e-06 29.0 0.0 0.00027 21.4 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.12 T128761_1 - 0.09 12.0 0.1 0.17 11.1 0.1 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein VWA_3 PF13768.4 T128761_2 - 3.9e-47 159.9 0.0 4.1e-39 133.8 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain TUDOR PF00567.22 T091743_2 - 9.5e-38 128.8 0.1 2.8e-20 72.4 0.0 2.9 2 1 0 2 2 2 2 Tudor domain Agenet PF05641.10 T091743_2 - 0.00033 21.0 0.0 0.57 10.6 0.0 2.6 2 0 0 2 2 2 2 Agenet domain Gag_p10 PF02337.15 T354562_2 - 1.5e-13 50.2 0.1 2.9e-13 49.3 0.1 1.4 1 0 0 1 1 1 1 Retroviral GAG p10 protein DUF4615 PF15393.4 T354562_3 - 1.7e-36 125.3 0.2 2.8e-36 124.6 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4615) CPCFC PF17223.1 T026588_1 - 0.13 11.9 30.7 1.6 8.4 0.5 6.6 5 0 0 5 5 5 0 Cuticle protein CPCFC Hemopexin PF00045.17 T026588_2 - 4.2e-14 52.1 3.3 1.7e-09 37.3 0.2 3.4 3 0 0 3 3 3 2 Hemopexin Somatomedin_B PF01033.15 T026588_2 - 1.3e-10 41.4 17.9 3.2e-10 40.1 17.9 1.8 1 0 0 1 1 1 1 Somatomedin B domain Hid1 PF12722.5 T154148_1 - 3.2e-123 412.4 0.0 4e-123 412.1 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.7 T154148_1 - 4.5e-112 375.4 0.1 2.6e-64 217.7 0.8 2.0 2 0 0 2 2 2 2 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.5 T154148_3 - 7e-150 500.6 0.0 8.6e-150 500.3 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.7 T154148_3 - 6.6e-130 434.4 0.0 8.3e-130 434.0 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein ANAPC4_WD40 PF12894.5 T192057_3 - 0.11 12.7 0.0 0.96 9.7 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Spectrin PF00435.19 T115145_1 - 2e-105 346.3 101.7 1e-18 67.6 4.5 8.2 8 0 0 8 8 8 8 Spectrin repeat PH PF00169.27 T115145_1 - 6e-05 23.4 0.0 0.00012 22.4 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 T115145_1 - 0.0018 18.5 0.0 0.0048 17.1 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain DUF948 PF06103.9 T115145_1 - 0.78 9.9 3.8 13 6.0 0.0 3.7 5 0 0 5 5 5 0 Bacterial protein of unknown function (DUF948) LPP PF04728.11 T115145_1 - 6.5 7.1 5.2 11 6.3 0.1 3.4 2 1 0 2 2 2 0 Lipoprotein leucine-zipper Spectrin PF00435.19 T115145_3 - 1.4e-214 697.2 244.2 1.4e-17 63.9 0.9 22.9 23 0 0 23 23 23 21 Spectrin repeat Matrilin_ccoil PF10393.7 T115145_3 - 0.24 11.2 2.3 1.1 9.0 0.2 3.7 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin IRF PF00605.15 T115145_3 - 0.55 10.4 4.3 1.3 9.2 0.0 3.3 3 0 0 3 3 3 0 Interferon regulatory factor transcription factor zf-ZPR1 PF03367.11 T115145_3 - 4.5 7.0 10.8 0.051 13.3 0.7 3.1 3 0 0 3 3 3 0 ZPR1 zinc-finger domain Reo_sigmaC PF04582.10 T115145_3 - 5.9 6.1 12.3 19 4.4 1.0 4.5 3 1 1 4 4 4 0 Reovirus sigma C capsid protein DUF1180 PF06679.10 T212215_1 - 6 7.1 6.1 15 5.8 6.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) MIP PF00230.18 T211338_2 - 4.1e-06 26.5 1.9 6.4e-06 25.9 1.9 1.2 1 0 0 1 1 1 1 Major intrinsic protein SH3BP5 PF05276.12 T238619_3 - 7.7e-88 294.1 21.7 1.1e-87 293.6 21.7 1.1 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) DUF1068 PF06364.10 T238619_3 - 4.9 6.9 9.1 0.48 10.1 3.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1068) Exonuc_VII_L PF02601.13 T238619_3 - 7.8 5.8 16.2 16 4.8 16.2 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit Copine PF07002.14 T302674_3 - 3.5e-86 288.0 0.1 5.7e-55 186.0 0.0 2.1 2 0 0 2 2 2 2 Copine C2 PF00168.28 T302674_3 - 5.7e-30 103.5 0.1 5.5e-14 52.2 0.0 2.3 2 0 0 2 2 2 2 C2 domain VCBS PF13517.4 T302674_3 - 0.083 13.4 0.2 0.19 12.2 0.2 1.6 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella vWA-TerF-like PF10138.7 T302674_3 - 0.14 12.1 0.0 2.9 7.8 0.0 2.1 2 0 0 2 2 2 0 vWA found in TerF C terminus DUF1822 PF08852.9 T382134_2 - 0.17 10.7 1.4 0.24 10.2 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1822) RNase_T PF00929.22 T382134_3 - 0.033 14.6 0.0 0.051 14.0 0.0 1.3 1 0 0 1 1 1 0 Exonuclease Glyco_transf_64 PF09258.8 T350147_3 - 2.2e-104 348.0 0.6 2.9e-104 347.6 0.6 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.13 T350147_3 - 9.1e-62 208.8 0.0 1.4e-61 208.3 0.0 1.2 1 0 0 1 1 1 1 Exostosin family DUF1158 PF06643.9 T069736_2 - 0.28 11.5 2.0 0.57 10.5 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1158) zf-CCCH PF00642.22 T329083_1 - 4.4e-17 61.4 31.6 1.3e-06 28.0 0.5 5.9 5 0 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 T329083_1 - 4.8e-09 36.3 19.5 6.4e-09 35.9 8.0 2.9 1 1 1 2 2 2 2 Zinc-finger containing family Torus PF16131.3 T329083_1 - 8.8e-06 26.3 28.9 0.0016 19.0 0.4 5.4 1 1 4 5 5 5 4 Torus domain zf-C3H1 PF10650.7 T329083_1 - 0.22 11.2 9.0 4.9 6.9 0.2 4.1 3 0 0 3 3 3 0 Putative zinc-finger domain zf-CCHC PF00098.21 T329083_2 - 1.3e-05 24.9 3.6 1.3e-05 24.9 3.6 2.4 2 0 0 2 2 2 1 Zinc knuckle RhoGEF PF00621.18 T199335_3 - 1.3e-45 155.7 3.6 1.9e-45 155.2 3.6 1.3 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 T199335_3 - 4.4e-10 38.9 1.9 8e-10 38.0 1.9 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 T199335_3 - 3.5e-08 32.9 0.0 8.4e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 T199335_3 - 5e-08 33.3 0.0 1.1e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.4 T199335_3 - 3.7e-07 29.7 0.2 7.6e-07 28.8 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF3508 PF12018.6 T307715_1 - 1.3e-100 336.4 2.0 1.7e-100 336.0 2.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3508) Nuc_sug_transp PF04142.13 T307715_3 - 1.1e-119 399.2 21.3 1.6e-119 398.6 21.3 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter Spt20 PF12090.6 T093033_1 - 4.5 6.7 20.0 0.049 13.1 1.2 2.4 2 0 0 2 2 2 0 Spt20 family Spt20 PF12090.6 T093033_3 - 5.3e-34 117.7 8.8 1.5e-19 70.4 0.0 2.6 2 1 1 3 3 3 2 Spt20 family CAP PF00188.24 T346105_3 - 7.9e-24 84.8 2.1 1.2e-23 84.1 2.1 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family zf-H2C2_2 PF13465.4 T176792_1 - 1.4e-105 341.3 131.3 1.5e-07 31.4 0.4 19.8 19 0 0 19 19 19 18 Zinc-finger double domain zf-C2H2 PF00096.24 T176792_1 - 1.6e-59 195.0 153.3 8.9e-05 22.6 1.0 21.0 20 0 0 20 20 20 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T176792_1 - 8.8e-26 88.2 151.1 0.023 15.4 1.0 20.2 21 0 0 21 21 21 15 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T176792_1 - 1.8e-07 30.8 115.8 0.19 11.6 0.3 17.7 18 0 0 18 18 18 10 C2H2-type zinc finger zf-C2H2_8 PF15909.3 T176792_1 - 0.00013 22.1 58.7 0.11 12.7 1.1 8.7 2 2 5 8 8 8 5 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.8 T176792_1 - 0.025 14.6 105.4 0.063 13.3 2.2 12.2 4 3 10 16 16 16 0 Zinc ribbon domain BolA PF01722.16 T176792_1 - 0.44 10.7 16.6 0.65 10.2 0.3 5.4 4 2 2 6 6 6 0 BolA-like protein zf-H2C2_2 PF13465.4 T176792_2 - 2.4e-112 362.6 147.6 8e-08 32.3 1.2 19.5 19 0 0 19 19 19 18 Zinc-finger double domain zf-C2H2 PF00096.24 T176792_2 - 1.6e-76 248.5 147.4 1.3e-05 25.2 1.4 19.2 18 0 0 18 18 18 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T176792_2 - 1.4e-30 103.2 154.1 0.0053 17.3 1.2 19.8 19 0 0 19 19 19 17 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T176792_2 - 3.1e-13 49.5 80.5 0.25 11.6 0.3 16.6 18 0 0 18 18 18 10 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T176792_2 - 1.1e-05 25.3 92.4 0.27 11.3 1.0 11.2 5 3 8 14 14 14 11 Zinc ribbon domain zf-met PF12874.5 T176792_2 - 0.021 15.1 122.4 0.21 11.9 1.3 17.6 17 0 0 17 17 17 0 Zinc-finger of C2H2 type KRAB PF01352.25 T176792_3 - 9.9e-21 73.0 0.2 2e-20 72.1 0.2 1.5 1 0 0 1 1 1 1 KRAB box THRAP3_BCLAF1 PF15440.4 T008024_2 - 1.4e-197 658.7 111.3 2.5e-174 581.9 78.2 3.4 3 0 0 3 3 3 2 THRAP3/BCLAF1 family SH3_9 PF14604.4 T008024_3 - 2e-39 133.1 6.4 2.3e-14 52.8 0.2 3.8 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.15 T008024_3 - 1.1e-34 117.7 1.2 7.7e-15 54.2 0.1 3.6 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 T008024_3 - 9.1e-32 108.3 1.8 5.7e-14 51.3 0.0 3.4 3 0 0 3 3 3 3 SH3 domain Myb_DNA-binding PF00249.29 T327842_1 - 1.5e-27 95.3 12.2 7.5e-19 67.5 0.6 4.3 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T327842_1 - 2e-15 56.6 4.0 1.7e-08 34.4 0.1 3.8 3 1 1 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.4 T327842_1 - 0.83 10.0 5.2 0.2 11.9 0.4 2.5 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain DUF1725 PF08333.9 T140577_1 - 2.4e-05 23.7 0.9 5.4e-05 22.6 0.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T140577_1 - 3.4e-05 23.3 0.1 6.3e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) F-box-like PF12937.5 T140577_2 - 5e-07 29.4 3.3 1.4e-06 28.0 3.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T140577_2 - 0.0061 16.3 1.8 0.019 14.7 1.8 1.9 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.4 T140577_2 - 4.8 7.4 5.0 2.1 8.5 1.2 2.5 2 0 0 2 2 2 0 Leucine Rich repeat Mito_carr PF00153.25 T061187_2 - 1.7e-52 175.2 0.3 2.8e-19 68.7 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Filament PF00038.19 T147420_3 - 2.1e-70 237.7 35.2 1.3e-60 205.4 25.5 2.1 1 1 1 2 2 2 2 Intermediate filament protein DUF5082 PF16888.3 T147420_3 - 7.8 6.7 11.4 0.1 12.8 2.5 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) TMEM132 PF16070.3 T089344_2 - 1.5e-144 481.4 3.6 2e-144 481.0 3.6 1.2 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_N PF15705.3 T089344_2 - 7.5e-57 190.7 0.0 1.3e-56 189.9 0.0 1.4 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term TMEM132D_C PF15706.3 T089344_2 - 7.1e-37 124.9 0.0 1.4e-36 124.0 0.0 1.6 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Nramp PF01566.16 T207684_1 - 2.8e-16 59.3 0.1 3.8e-16 58.9 0.1 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein NIF PF03031.16 T207684_2 - 2.6e-50 170.1 0.0 3.5e-50 169.7 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Nramp PF01566.16 T207684_2 - 5.3e-11 42.0 0.0 8.2e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Nramp PF01566.16 T207684_3 - 6.2e-73 245.7 11.1 8.9e-73 245.2 11.1 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Tropomodulin PF03250.12 T020766_1 - 5.1e-57 191.7 6.6 7.9e-57 191.1 6.6 1.3 1 0 0 1 1 1 1 Tropomodulin YL1 PF05764.11 T020766_2 - 3.2e-52 178.0 14.7 4.3e-52 177.5 14.7 1.2 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.9 T020766_2 - 9.7e-12 44.3 0.6 1.7e-11 43.5 0.6 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DUF3523 PF12037.6 T000833_1 - 3e-65 220.1 18.5 1.5e-28 99.8 0.5 4.1 3 1 1 4 4 4 4 Domain of unknown function (DUF3523) AAA PF00004.27 T000833_1 - 4.8e-33 114.3 0.0 5.6e-17 62.3 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 T000833_1 - 3.3e-09 37.2 0.3 0.0052 17.0 0.0 3.4 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.4 T000833_1 - 6.5e-09 36.0 1.9 0.13 12.4 0.0 4.5 3 1 0 4 4 4 2 AAA domain RuvB_N PF05496.10 T000833_1 - 1.3e-08 34.3 0.0 0.0041 16.3 0.0 2.2 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_24 PF13479.4 T000833_1 - 1.3e-06 28.2 0.1 0.056 13.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.19 T000833_1 - 6e-06 25.7 0.5 0.14 11.4 0.1 2.7 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ATPase PF06745.11 T000833_1 - 8.4e-06 25.2 0.0 0.1 11.8 0.0 2.2 2 0 0 2 2 2 2 KaiC AAA_5 PF07728.12 T000833_1 - 1.4e-05 25.0 0.3 0.22 11.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.4 T000833_1 - 5.2e-05 23.3 0.0 0.34 10.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain Sigma54_activ_2 PF14532.4 T000833_1 - 7.9e-05 22.7 0.0 0.18 11.8 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_18 PF13238.4 T000833_1 - 9.4e-05 22.8 0.0 0.66 10.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.20 T000833_1 - 9.5e-05 22.6 0.3 0.68 10.2 0.0 2.3 2 0 0 2 2 2 2 RNA helicase AAA_25 PF13481.4 T000833_1 - 0.00012 21.6 0.1 0.58 9.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain TsaE PF02367.15 T000833_1 - 0.00026 20.9 0.1 0.98 9.3 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.9 T000833_1 - 0.00053 19.7 0.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.24 T000833_1 - 0.00086 18.9 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 2 Sigma-54 interaction domain NACHT PF05729.10 T000833_1 - 0.0012 18.6 0.0 2.1 8.1 0.0 2.4 2 0 0 2 2 2 2 NACHT domain AAA_28 PF13521.4 T000833_1 - 0.0044 17.1 0.0 4.6 7.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.11 T000833_1 - 0.0047 15.8 0.0 0.75 8.5 0.0 2.2 2 0 0 2 2 2 1 TIP49 C-terminus IstB_IS21 PF01695.15 T000833_1 - 0.0083 15.8 0.1 5.3 6.7 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein PhoH PF02562.14 T000833_1 - 0.038 13.3 0.1 8 5.7 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.4 T000833_1 - 0.15 11.6 3.3 11 5.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.4 T000833_1 - 0.17 12.2 4.9 5.9 7.2 0.0 2.6 3 0 0 3 3 2 0 AAA domain DUF3523 PF12037.6 T000833_3 - 4.5e-56 190.0 27.7 6.7e-56 189.4 27.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) TLV_coat PF00429.17 T321098_1 - 2.2e-07 29.9 9.4 3.1e-06 26.0 0.1 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) TLV_coat PF00429.17 T321098_2 - 1.5e-09 37.0 1.2 8e-05 21.4 0.0 2.2 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) TNF PF00229.16 T380686_1 - 1.1e-27 96.4 0.0 2e-27 95.5 0.0 1.5 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Myosin_head PF00063.19 T116818_1 - 1.8e-288 958.3 4.1 1.8e-288 958.3 4.1 1.6 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.17 T116818_1 - 4.2e-32 110.4 2.9 1.1e-31 109.0 1.5 2.6 2 0 0 2 2 2 1 DIL domain IQ PF00612.25 T116818_1 - 1.2e-24 83.6 46.8 7.2e-06 25.2 3.9 6.9 6 0 0 6 6 6 6 IQ calmodulin-binding motif Myosin_N PF02736.17 T116818_1 - 0.044 13.5 0.1 0.092 12.4 0.1 1.5 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_22 PF13401.4 T116818_1 - 0.055 13.6 0.0 0.19 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 T116818_1 - 0.22 11.8 0.0 0.22 11.8 0.0 2.7 2 1 1 3 3 3 0 AAA ATPase domain Ig_2 PF13895.4 T380117_1 - 9.4e-100 327.0 0.5 1e-10 41.6 0.0 12.2 12 0 0 12 12 12 12 Immunoglobulin domain Ig_3 PF13927.4 T380117_1 - 6.5e-57 190.0 0.1 3.3e-05 24.3 0.0 12.6 12 0 0 12 12 12 12 Immunoglobulin domain ig PF00047.23 T380117_1 - 3e-35 120.1 9.3 0.0012 18.8 0.0 12.5 12 2 0 12 12 12 9 Immunoglobulin domain I-set PF07679.14 T380117_1 - 1e-21 76.6 0.2 0.05 13.5 0.0 10.4 10 0 0 10 10 10 5 Immunoglobulin I-set domain V-set PF07686.15 T380117_1 - 9.9e-15 54.5 19.2 0.015 15.4 0.1 13.0 13 5 3 17 17 17 3 Immunoglobulin V-set domain Izumo-Ig PF16706.3 T380117_1 - 0.00079 19.3 0.0 11 6.0 0.0 5.8 7 0 0 7 7 7 1 Izumo-like Immunoglobulin domain UEV PF05743.11 T380117_1 - 0.0018 18.0 1.2 0.47 10.2 0.0 3.5 3 0 0 3 3 3 1 UEV domain V-set_2 PF15910.3 T380117_1 - 0.081 12.9 2.8 6.1 6.9 0.1 4.5 5 0 0 5 5 5 0 ICOS V-set domain Dynein_heavy PF03028.13 T243399_2 - 4.7e-221 735.7 0.0 1.2e-220 734.3 0.0 1.6 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor AAA_8 PF12780.5 T243399_2 - 7.4e-82 274.4 0.1 1.2e-81 273.7 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 T243399_2 - 3.2e-51 174.1 0.0 7e-51 173.0 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 MT PF12777.5 T243399_2 - 4e-35 121.3 6.5 6e-35 120.7 6.5 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 T243399_2 - 1.2e-05 25.2 0.0 0.016 15.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 T243399_2 - 0.00013 22.3 1.0 0.22 11.8 0.0 3.5 4 0 0 4 4 4 2 AAA ATPase domain AAA PF00004.27 T243399_2 - 0.0027 18.0 0.0 1.6 9.0 0.0 3.7 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 T243399_2 - 0.0037 17.4 0.1 0.3 11.2 0.0 3.1 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.18 T243399_2 - 0.024 13.6 0.9 0.26 10.2 0.0 2.6 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_18 PF13238.4 T243399_2 - 0.056 13.8 0.0 20 5.5 0.0 3.6 3 0 0 3 3 3 0 AAA domain Spc7 PF08317.9 T243399_2 - 0.16 10.7 16.6 0.75 8.5 1.4 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein zf-C4H2 PF10146.7 T243399_2 - 0.38 10.9 3.1 1.4 9.1 3.2 1.9 2 0 0 2 2 1 0 Zinc finger-containing protein Alanine_zipper PF11839.6 T243399_2 - 1.4 9.1 8.8 4.4 7.5 8.8 1.8 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein AAA_9 PF12781.5 T243399_3 - 2.1e-90 301.5 0.7 2.9e-90 301.1 0.7 1.2 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 Dynein_heavy PF03028.13 T243399_3 - 1.8e-43 148.7 0.0 6e-37 127.1 0.0 2.4 3 0 0 3 3 3 2 Dynein heavy chain and region D6 of dynein motor MT PF12777.5 T243399_3 - 9.1e-10 37.9 0.0 1.4e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 T243399_3 - 2e-06 27.7 0.0 3.3e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.4 T243399_3 - 0.057 13.0 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 T243399_3 - 0.059 13.7 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter rve PF00665.24 T123690_2 - 8.6e-05 22.6 0.0 0.00015 21.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.21 T123690_2 - 0.00068 19.5 7.8 0.00074 19.4 2.5 3.0 2 0 0 2 2 2 1 Zinc knuckle Pkinase PF00069.23 T123690_3 - 9.6e-38 129.9 0.0 1.7e-37 129.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T123690_3 - 7.2e-36 123.7 0.0 1.1e-35 123.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase COR PF16095.3 T123690_3 - 1.2e-23 83.8 0.0 2e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain LRR_8 PF13855.4 T123690_3 - 4.5e-23 80.6 24.5 1.5e-05 24.6 0.4 5.8 5 0 0 5 5 5 5 Leucine rich repeat Roc PF08477.11 T123690_3 - 1.8e-20 73.2 0.0 3.7e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.5 T123690_3 - 5.4e-20 70.9 29.2 0.00014 22.0 2.5 6.5 5 1 1 6 6 6 4 Leucine Rich repeats (2 copies) Ank_2 PF12796.5 T123690_3 - 1.1e-09 38.6 0.0 0.0033 17.8 0.0 2.6 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Arf PF00025.19 T123690_3 - 9.8e-07 28.3 0.0 1.7e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 T123690_3 - 2.2e-05 24.0 0.0 3.7e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Ras family Ank_4 PF13637.4 T123690_3 - 7.4e-05 23.1 0.0 0.33 11.5 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 T123690_3 - 0.00056 20.0 0.4 11 6.8 0.0 4.4 4 0 0 4 4 4 0 Ankyrin repeat Ank_5 PF13857.4 T123690_3 - 0.0018 18.5 2.5 6.2 7.2 0.1 4.3 2 1 2 4 4 4 1 Ankyrin repeats (many copies) Gag_p30 PF02093.14 T123690_3 - 0.0066 15.9 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein Ank PF00023.28 T123690_3 - 0.011 16.0 0.2 1.6 9.2 0.0 3.6 4 0 0 4 4 3 0 Ankyrin repeat MMR_HSR1 PF01926.21 T123690_3 - 0.072 13.1 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase LRR_1 PF00560.31 T123690_3 - 0.15 12.5 26.2 16 6.3 0.2 9.2 7 1 1 8 8 8 0 Leucine Rich Repeat LRR_6 PF13516.4 T123690_3 - 5.4 7.2 25.7 1.9 8.6 0.2 6.7 7 0 0 7 7 7 0 Leucine Rich repeat RRM_1 PF00076.20 T326450_2 - 4e-12 45.6 0.0 6.1e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF-4B PF06273.9 T326450_2 - 0.005 15.8 3.2 0.005 15.8 3.2 1.6 2 0 0 2 2 2 1 Plant specific eukaryotic initiation factor 4B zf-H2C2_2 PF13465.4 T174649_2 - 8e-34 114.4 48.8 2.5e-06 27.6 0.5 8.8 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 T174649_2 - 6.9e-24 82.8 66.8 6.5e-05 23.0 1.4 8.4 8 0 0 8 8 8 6 Zinc finger, C2H2 type KRAB PF01352.25 T174649_2 - 7.9e-23 79.7 0.0 1.5e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T174649_2 - 3.3e-06 27.3 73.3 0.0055 17.3 4.3 9.4 9 0 0 9 9 9 6 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T168872_1 - 3.7e-74 241.9 139.3 9.1e-08 32.1 1.5 15.8 15 0 0 15 15 15 14 Zinc-finger double domain KRAB PF01352.25 T168872_1 - 3.9e-46 154.3 0.5 1.8e-23 81.8 0.3 2.5 2 0 0 2 2 2 2 KRAB box zf-C2H2 PF00096.24 T168872_1 - 6.6e-32 108.0 130.7 0.00054 20.1 0.9 16.6 15 0 0 15 15 15 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T168872_1 - 1.4e-22 78.3 128.6 0.017 15.8 0.8 17.2 16 0 0 16 16 16 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T168872_1 - 4e-10 39.3 99.6 0.0013 18.5 3.5 14.7 14 0 0 14 14 14 10 C2H2-type zinc finger zf-trcl PF13451.4 T168872_1 - 1.9e-05 24.3 69.9 0.03 14.1 0.1 10.5 7 4 3 10 10 10 5 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.8 T168872_1 - 0.0032 17.4 89.0 0.028 14.4 1.8 10.2 1 1 12 13 13 13 9 Zinc ribbon domain RIIa PF02197.15 T168872_2 - 0.021 14.4 0.0 3.8 7.1 0.0 2.6 2 0 0 2 2 2 0 Regulatory subunit of type II PKA R-subunit zf-H2C2_2 PF13465.4 T168872_3 - 9.7e-89 288.0 126.7 6e-08 32.7 2.6 17.8 16 0 0 16 16 16 16 Zinc-finger double domain zf-C2H2 PF00096.24 T168872_3 - 1.4e-45 151.1 125.3 6.4e-05 23.1 0.1 16.3 15 0 0 15 15 15 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T168872_3 - 1.7e-33 112.2 123.5 0.0042 17.7 1.2 16.7 15 0 0 15 15 15 15 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T168872_3 - 1.8e-13 50.0 90.8 0.003 17.3 1.2 15.6 15 0 0 15 15 15 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T168872_3 - 0.00077 19.6 78.2 0.03 14.5 0.1 14.2 15 0 0 15 15 15 6 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T168872_3 - 0.0024 17.5 0.0 0.0024 17.5 0.0 10.5 11 0 0 11 11 11 4 zinc-finger C2H2-type zf-met PF12874.5 T168872_3 - 0.12 12.7 0.0 0.12 12.7 0.0 10.4 12 0 0 12 12 12 0 Zinc-finger of C2H2 type NMT_C PF02799.13 T037640_2 - 1e-80 270.1 0.0 1.5e-80 269.5 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.17 T037640_2 - 1.3e-75 252.5 0.0 2.1e-75 251.8 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_1 PF00583.23 T037640_2 - 0.0021 18.1 0.0 0.004 17.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Ras PF00071.20 T144680_1 - 4.9e-38 130.1 0.1 6.8e-38 129.7 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T144680_1 - 1.8e-27 95.8 0.0 2.8e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T144680_1 - 4e-10 39.3 0.0 5.8e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 T144680_1 - 4.3e-06 26.7 0.0 7.4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 T144680_1 - 0.0061 16.5 0.1 2.9 7.8 0.0 3.3 3 1 0 3 3 3 1 Dynamin family Gtr1_RagA PF04670.10 T144680_1 - 0.035 13.3 0.0 0.047 12.9 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region TniB PF05621.9 T144680_1 - 0.095 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.8 T144680_1 - 0.21 10.9 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Choline_transpo PF04515.10 T364176_1 - 2e-104 349.2 37.2 2e-104 349.2 37.2 2.7 3 0 0 3 3 3 1 Plasma-membrane choline transporter VWA PF00092.26 T352424_3 - 3.3e-28 99.0 0.2 2.9e-24 86.1 0.0 2.2 1 1 1 2 2 2 2 von Willebrand factor type A domain Collagen PF01391.16 T352424_3 - 1.4e-14 53.4 50.2 2.2e-08 33.6 29.2 2.7 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) VWA_2 PF13519.4 T352424_3 - 0.00011 22.6 0.0 0.028 14.9 0.0 2.5 1 1 1 2 2 2 2 von Willebrand factor type A domain VWA_3 PF13768.4 T352424_3 - 0.0019 18.0 0.1 0.0093 15.7 0.0 1.9 1 1 1 2 2 2 1 von Willebrand factor type A domain Septin PF00735.16 T155160_1 - 5.8e-110 366.8 2.0 7.2e-110 366.5 2.0 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 T155160_1 - 9.1e-09 35.3 0.0 1.5e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 T155160_1 - 6.7e-06 26.0 0.3 1.8e-05 24.6 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AIG1 PF04548.14 T155160_1 - 0.00016 21.0 0.1 0.00023 20.4 0.1 1.2 1 0 0 1 1 1 1 AIG1 family Roc PF08477.11 T155160_1 - 0.00055 20.0 0.1 0.00092 19.3 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.25 T155160_1 - 0.0006 19.3 1.1 0.0019 17.6 0.2 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.21 T155160_1 - 0.00097 19.1 1.7 0.036 14.0 0.7 2.2 1 1 1 2 2 2 1 Dynamin family Ras PF00071.20 T155160_1 - 0.0016 18.0 0.0 0.0028 17.1 0.0 1.4 1 0 0 1 1 1 1 Ras family FtsK_SpoIIIE PF01580.16 T155160_1 - 0.0054 16.0 0.0 0.0084 15.4 0.0 1.2 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.4 T155160_1 - 0.0077 16.5 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.25 T155160_1 - 0.0096 16.3 0.0 0.025 15.0 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.4 T155160_1 - 0.022 14.9 0.0 0.041 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.18 T155160_1 - 0.039 13.0 0.9 0.084 11.9 0.8 1.4 1 1 0 1 1 1 0 G-protein alpha subunit IIGP PF05049.11 T155160_1 - 0.056 12.3 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.4 T155160_1 - 0.085 12.5 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.4 T155160_1 - 0.1 12.2 0.4 0.2 11.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.20 T155160_1 - 0.15 10.9 0.1 0.21 10.4 0.1 1.1 1 0 0 1 1 1 0 NB-ARC domain RRM_1 PF00076.20 T058293_2 - 1.3e-50 168.9 0.0 1.1e-17 63.5 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 T058293_2 - 1.3e-07 31.4 0.0 0.19 11.6 0.0 3.7 3 0 0 3 3 3 3 RNA binding domain RRM_7 PF16367.3 T058293_2 - 0.00019 21.4 0.0 0.78 9.8 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.4 T058293_2 - 0.01 15.7 0.0 1 9.3 0.0 3.1 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.4 T058293_2 - 0.13 12.4 2.9 5.1 7.2 0.4 3.1 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter APG9 PF04109.14 T208022_3 - 2.1e-130 435.0 0.4 3.1e-130 434.5 0.4 1.3 1 0 0 1 1 1 1 Autophagy protein Apg9 MTABC_N PF16185.3 T208022_3 - 4.4e-76 255.4 0.1 8.6e-76 254.5 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region ABC_tran PF00005.25 T208022_3 - 3e-34 118.3 0.0 5.2e-34 117.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.21 T208022_3 - 1.7e-31 109.7 12.2 2.9e-31 109.0 12.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.17 T208022_3 - 1.8e-06 27.4 0.0 2.7e-05 23.6 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 T208022_3 - 0.0015 18.8 0.0 0.0044 17.3 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 T208022_3 - 0.0024 17.7 0.0 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 T208022_3 - 0.0067 16.0 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.4 T208022_3 - 0.0085 16.2 0.0 0.031 14.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.4 T208022_3 - 0.034 13.8 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.27 T208022_3 - 0.06 13.6 0.0 0.46 10.8 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Pkinase PF00069.23 T243043_3 - 7.7e-66 222.0 0.0 1.1e-65 221.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T243043_3 - 5.6e-26 91.2 0.0 8.4e-26 90.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 T243043_3 - 1.1e-05 24.8 0.1 1.9e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3534 PF12053.6 T039765_2 - 1.1e-57 194.3 1.3 1.8e-57 193.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3534) PDZ PF00595.22 T039765_2 - 7.3e-37 125.5 5.3 7.5e-16 58.1 0.2 3.5 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T039765_2 - 1.4e-13 50.8 0.5 1.7e-05 24.9 0.1 3.8 3 1 0 3 3 3 3 PDZ domain Ribosomal_60s PF00428.17 T043853_1 - 0.031 14.7 3.3 0.05 14.0 3.3 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF3719 PF12516.6 T043853_2 - 1.3e-25 88.7 0.3 2.7e-25 87.7 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3719) SNF2_N PF00176.21 T376241_1 - 2.9e-49 167.5 0.0 3.2e-48 164.1 0.0 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 T376241_1 - 2.8e-17 62.9 0.3 2.1e-16 60.1 0.2 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 T376241_1 - 1.2e-13 51.3 0.2 7e-13 48.8 0.0 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_34 PF13872.4 T376241_1 - 1.8e-05 23.6 0.0 3.2e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DEAD PF00270.27 T376241_1 - 0.00011 21.9 0.0 0.00024 20.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.6 T376241_1 - 0.00046 19.3 0.2 0.00086 18.4 0.2 1.3 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 TPR_11 PF13414.4 T376241_1 - 0.0014 18.1 0.0 0.0068 15.9 0.0 2.2 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.15 T376241_1 - 0.0062 16.4 0.9 2.9 8.1 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.26 T376241_1 - 0.023 14.4 2.1 0.45 10.3 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 T376241_1 - 0.066 13.3 1.2 3.3 8.0 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat YadA_head PF05658.12 T277249_1 - 0.16 12.3 3.1 0.42 10.9 3.1 1.7 1 0 0 1 1 1 0 Head domain of trimeric autotransporter adhesin DUF3512 PF12024.6 T277249_2 - 3.1e-84 282.0 0.2 3.1e-84 282.0 0.2 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3512) Bromodomain PF00439.23 T277249_2 - 1.3e-22 79.5 0.0 5.5e-22 77.5 0.1 1.9 2 0 0 2 2 2 1 Bromodomain SR-25 PF10500.7 T277249_2 - 0.22 11.0 15.2 0.4 10.1 15.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med19 PF10278.7 T277249_2 - 0.47 10.2 19.8 1 9.1 19.8 1.5 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 YadA_head PF05658.12 T277249_3 - 0.024 14.9 4.7 0.12 12.6 0.6 2.5 2 0 0 2 2 2 0 Head domain of trimeric autotransporter adhesin Homeobox PF00046.27 T083329_2 - 6.5e-23 80.2 6.1 1.3e-22 79.3 6.1 1.5 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 T083329_2 - 1.4e-08 34.1 2.1 1.4e-08 34.1 2.1 1.9 2 0 0 2 2 2 1 OAR domain Homeobox_KN PF05920.9 T083329_2 - 0.011 15.5 0.2 0.031 14.1 0.2 1.8 1 0 0 1 1 1 0 Homeobox KN domain HSP70 PF00012.18 T092501_2 - 2e-187 623.9 1.7 2e-187 623.9 1.7 2.8 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.11 T092501_2 - 1.8e-05 23.6 0.0 3.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.4 T092501_2 - 0.14 12.5 0.2 3.8 7.8 0.0 2.6 3 0 0 3 3 3 0 Cell division protein FtsA DUF1220 PF06758.11 T019151_1 - 3.4e-17 62.4 3.8 1.1e-16 60.7 3.8 2.0 1 0 0 1 1 1 1 Repeat of unknown function (DUF1220) Cnd1 PF12717.5 T019151_1 - 0.013 15.3 0.1 0.013 15.3 0.1 3.2 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 WD40 PF00400.30 T085814_1 - 1.7e-09 38.0 10.0 0.014 16.1 0.1 6.2 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T085814_1 - 0.0013 18.8 0.2 0.083 13.1 0.0 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain MRI PF15325.4 T333806_3 - 8.8e-50 168.2 0.8 1.7e-49 167.3 0.8 1.5 1 0 0 1 1 1 1 Modulator of retrovirus infection WD40 PF00400.30 T333806_3 - 2.8e-08 34.1 5.4 0.044 14.5 0.0 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T333806_3 - 1.8e-05 24.8 0.0 0.012 15.8 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T333806_3 - 0.057 12.2 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GIT_CC PF16559.3 T333806_3 - 0.13 12.2 1.8 0.25 11.3 1.8 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor PFK PF00365.18 T077766_1 - 7.8e-201 665.0 6.8 5.6e-109 363.7 0.8 2.1 2 0 0 2 2 2 2 Phosphofructokinase Fanconi_A_N PF15865.3 T138885_1 - 1.2e-147 491.6 8.6 4.8e-110 368.0 0.6 2.5 2 0 0 2 2 2 2 Fanconi anaemia group A protein N terminus Fanconi_A PF03511.12 T138885_1 - 2.9e-31 107.0 3.9 1.4e-30 104.8 3.9 2.3 1 0 0 1 1 1 1 Fanconi anaemia group A protein SAM_1 PF00536.28 T084808_3 - 1.7e-34 117.9 1.0 7.1e-16 58.3 0.1 2.7 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) Ank_5 PF13857.4 T084808_3 - 1.9e-29 101.1 2.9 1.4e-07 31.5 0.1 4.9 3 1 2 5 5 5 4 Ankyrin repeats (many copies) SAM_2 PF07647.15 T084808_3 - 7e-28 96.4 0.4 9.3e-15 54.4 0.1 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Ank_2 PF12796.5 T084808_3 - 3.4e-26 91.5 3.7 1.6e-12 47.7 0.7 3.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T084808_3 - 2.7e-24 85.1 2.1 4e-08 33.5 0.1 4.7 4 1 1 5 5 5 4 Ankyrin repeats (many copies) PID PF00640.21 T084808_3 - 6e-20 71.6 0.7 1.1e-19 70.8 0.7 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Ank_3 PF13606.4 T084808_3 - 1.2e-19 68.2 1.0 0.0019 18.4 0.0 6.6 5 1 1 6 6 6 3 Ankyrin repeat Ank PF00023.28 T084808_3 - 2e-19 68.9 2.5 0.0014 18.9 0.4 5.7 5 0 0 5 5 5 4 Ankyrin repeat PTB PF08416.11 T084808_3 - 0.00037 20.5 0.1 0.00069 19.6 0.1 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.4 T084808_3 - 0.0098 15.6 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Coq4 PF05019.11 T084808_3 - 0.033 13.4 0.0 0.11 11.6 0.0 1.7 1 1 0 1 1 1 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 DUF4587 PF15248.4 T152264_2 - 5.1e-25 87.9 1.5 9.4e-25 87.1 1.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4587) Ank_2 PF12796.5 T057984_1 - 1.3e-11 44.8 0.1 2e-11 44.2 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T057984_1 - 1.5e-09 37.8 0.1 0.00039 20.6 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 T057984_1 - 6.7e-08 32.1 0.1 0.014 15.7 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.4 T057984_1 - 1.3e-06 28.6 0.2 4e-05 24.0 0.1 2.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 T057984_1 - 0.00021 21.4 0.5 0.21 12.0 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat PTN_MK_N PF05196.11 T057984_2 - 4.3e-26 90.8 12.3 4.3e-26 90.8 12.3 3.0 4 0 0 4 4 4 1 PTN/MK heparin-binding protein family, N-terminal domain PTN_MK_C PF01091.16 T057984_2 - 7.2e-24 83.8 12.0 7.2e-24 83.8 12.0 2.4 2 0 0 2 2 2 1 PTN/MK heparin-binding protein family, C-terminal domain DAGK_acc PF00609.17 T057984_3 - 4.8e-46 156.9 0.0 6.9e-46 156.4 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 T057984_3 - 1.3e-28 99.0 0.0 2.4e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 T057984_3 - 1.3e-09 37.7 13.8 1.3e-09 37.7 13.8 3.1 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) fn3 PF00041.19 T365531_2 - 0.15 12.3 0.0 0.56 10.5 0.0 1.9 1 1 0 1 1 1 0 Fibronectin type III domain TRM PF02005.14 T169133_1 - 6.5e-151 502.7 0.0 8.2e-151 502.3 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase zf-CCCH PF00642.22 T169133_1 - 3.9e-06 26.5 5.9 3.9e-06 26.5 5.9 2.4 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Met_10 PF02475.14 T169133_1 - 1.7e-05 24.6 0.0 2.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Torus PF16131.3 T169133_1 - 0.0017 18.9 0.4 0.0042 17.6 0.4 1.6 1 0 0 1 1 1 1 Torus domain Cons_hypoth95 PF03602.13 T169133_1 - 0.014 14.9 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 HLH PF00010.24 T169133_3 - 7.4e-14 51.3 0.0 1.3e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Acylphosphatase PF00708.16 T107446_2 - 2e-20 72.8 0.2 3e-20 72.3 0.2 1.3 1 0 0 1 1 1 1 Acylphosphatase MutL_C PF08676.9 T107446_3 - 1.6e-11 44.1 0.2 5.5e-11 42.3 0.2 1.8 1 1 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.17 T107446_3 - 3.5e-10 39.5 0.0 3e-09 36.5 0.0 2.2 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.4 T107446_3 - 1.3e-05 24.9 0.1 2.3e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 T107446_3 - 3.2e-05 24.3 0.0 6e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Homeobox PF00046.27 T079579_1 - 5.2e-20 70.9 9.6 9.9e-20 70.0 9.6 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox PF00046.27 T079579_3 - 2.6e-59 196.7 38.1 1.4e-20 72.7 8.1 3.5 3 0 0 3 3 3 3 Homeobox domain Homeobox_KN PF05920.9 T079579_3 - 0.025 14.3 14.9 0.6 9.9 0.7 3.7 3 0 0 3 3 3 0 Homeobox KN domain DUF2209 PF09974.7 T079579_3 - 0.092 13.0 0.5 0.91 9.7 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2209) FAM86 PF14904.4 T063247_2 - 6.4e-15 54.9 0.5 1.6e-14 53.6 0.1 1.9 2 0 0 2 2 2 1 Family of unknown function SH3_2 PF07653.15 T151368_3 - 2.1e-35 120.1 0.0 4.2e-11 42.2 0.0 3.7 3 0 0 3 3 3 3 Variant SH3 domain SH3_9 PF14604.4 T151368_3 - 2.8e-30 103.8 1.9 2.1e-10 40.1 0.0 3.7 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 T151368_3 - 1.7e-13 49.8 0.0 0.00078 18.9 0.0 3.6 3 0 0 3 3 3 3 SH3 domain fn3 PF00041.19 T151368_3 - 0.003 17.7 0.2 6.4 7.1 0.1 3.5 2 1 0 2 2 2 2 Fibronectin type III domain ProSAAS PF07259.10 T086765_1 - 0.023 14.5 1.9 0.038 13.8 1.9 1.2 1 0 0 1 1 1 0 ProSAAS precursor Peptidase_C48 PF02902.17 T258431_2 - 9.7e-22 77.7 2.7 2.8e-15 56.6 0.7 2.3 1 1 1 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain DEK_C PF08766.9 T258431_2 - 0.034 14.0 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 DEK C terminal domain zf-RING_2 PF13639.4 T294081_3 - 2.3e-13 50.0 6.5 1.1e-12 47.9 6.5 2.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.5 T294081_3 - 6.7e-09 35.8 6.0 2e-08 34.2 6.0 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 T294081_3 - 2e-08 33.8 5.9 6.7e-08 32.1 5.9 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 T294081_3 - 8.9e-08 31.6 3.1 8.9e-08 31.6 3.1 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.23 T294081_3 - 9.5e-08 31.7 5.3 9.5e-08 31.7 5.3 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T294081_3 - 9.7e-07 28.5 4.3 4.2e-06 26.5 4.3 2.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 T294081_3 - 2.3e-06 27.2 3.6 2.3e-06 27.2 3.6 3.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T294081_3 - 0.00032 20.5 2.9 0.00032 20.5 2.9 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 T294081_3 - 0.00068 19.5 1.3 0.0023 17.8 1.3 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.5 T294081_3 - 0.48 10.5 5.7 1.5 8.9 5.7 1.9 1 0 0 1 1 1 0 RING-variant domain Mucin15 PF15672.3 T178753_2 - 6.3e-05 22.5 0.0 6.3e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 Cell-membrane associated Mucin15 Peptidase_C2 PF00648.19 T187280_2 - 1.5e-28 99.6 0.0 2e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C2 PF00648.19 T187280_3 - 3.9e-48 163.8 0.1 5.6e-48 163.3 0.1 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 T187280_3 - 2.8e-41 141.0 0.0 4.6e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 T187280_3 - 0.00025 20.3 0.0 0.029 13.8 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 T187280_3 - 0.001 18.7 0.0 1.9 8.5 0.0 3.4 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 T187280_3 - 0.12 12.8 0.3 4.8 7.6 0.1 2.9 3 0 0 3 3 3 0 EF-hand domain pair LIM PF00412.20 T003820_1 - 1.9e-28 98.3 46.1 2.4e-15 56.4 7.0 3.7 4 0 0 4 4 4 3 LIM domain FANCAA PF15146.4 T156521_2 - 2.8e-197 656.0 1.2 3.6e-197 655.6 1.2 1.1 1 0 0 1 1 1 1 Fanconi anemia-associated NPL4 PF05021.13 T156521_3 - 1.7e-124 415.1 0.0 2.2e-124 414.7 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.13 T156521_3 - 6.7e-61 204.5 0.2 1.6e-60 203.3 0.2 1.7 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.6 T156521_3 - 1.8e-32 111.5 0.0 2.9e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Pkinase PF00069.23 T060899_1 - 2.6e-54 184.2 0.0 3.9e-54 183.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.20 T060899_1 - 2.3e-51 174.9 0.0 3.5e-51 174.3 0.0 1.2 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 T060899_1 - 4e-27 95.0 0.0 6.5e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.8 T060899_1 - 2.6e-19 69.0 19.9 2.6e-19 69.0 19.9 6.2 5 1 1 6 6 5 2 DMPK coiled coil domain like C1_1 PF00130.20 T060899_1 - 2.2e-09 36.9 0.7 2.2e-09 36.9 0.7 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 T060899_1 - 4.1e-07 29.5 0.0 9.3e-07 28.3 0.0 1.6 1 0 0 1 1 1 1 Kinase-like PH PF00169.27 T060899_1 - 0.00015 22.1 0.0 0.00046 20.5 0.0 1.8 2 0 0 2 2 2 1 PH domain Pkinase_C PF00433.22 T060899_1 - 0.0011 19.5 0.1 0.0024 18.4 0.1 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain PBD PF00786.26 T060899_1 - 0.003 17.8 0.4 0.008 16.4 0.4 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain FTA2 PF13095.4 T060899_1 - 0.017 14.6 0.0 6.4 6.2 0.0 2.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 IncA PF04156.12 T060899_1 - 0.17 11.5 72.5 0.0086 15.7 20.0 4.4 4 0 0 4 4 4 0 IncA protein APG6 PF04111.10 T060899_1 - 3.6 6.7 56.2 4.2 6.5 10.8 3.7 3 1 0 3 3 3 0 Autophagy protein Apg6 Filament PF00038.19 T060899_1 - 9.8 5.5 59.3 0.28 10.6 10.7 3.5 1 1 0 3 3 3 0 Intermediate filament protein UPF0515 PF15135.4 T168143_1 - 4.1e-126 419.6 3.7 5.1e-126 419.3 3.7 1.1 1 0 0 1 1 1 1 Uncharacterised protein UPF0515 zf-3CxxC_2 PF17180.2 T168143_1 - 0.0026 18.3 11.9 0.049 14.2 1.2 2.6 1 1 1 2 2 2 2 Zinc-binding domain zinc_ribbon_4 PF13717.4 T168143_1 - 0.012 15.4 10.2 0.71 9.7 0.1 2.9 2 1 1 3 3 3 0 zinc-ribbon domain Zn-ribbon_8 PF09723.8 T168143_1 - 0.042 13.8 10.4 0.23 11.5 1.9 2.8 2 1 0 2 2 2 0 Zinc ribbon domain zf-RING_4 PF14570.4 T168143_1 - 0.2 11.3 4.9 7.7 6.2 0.1 2.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.10 T168143_1 - 0.95 9.4 5.3 4 7.4 4.3 2.2 1 1 1 2 2 2 0 zinc-ribbons Antimicrobial23 PF16048.3 T168143_1 - 3.3 7.3 7.2 0.19 11.3 1.3 2.0 2 0 0 2 2 2 0 Frog antimicrobial peptide HypA PF01155.17 T168143_1 - 4.7 7.1 6.1 5.5 6.9 4.1 2.0 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_10 PF10058.7 T168143_1 - 5.3 6.7 5.5 4.4 7.0 1.8 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Ribosomal_L32p PF01783.21 T168143_3 - 9.5 6.4 9.2 0.18 12.0 0.6 2.6 4 0 0 4 4 4 0 Ribosomal L32p protein family BNR_2 PF13088.4 T211905_2 - 1.8e-30 106.1 0.0 1e-25 90.5 0.0 2.2 2 0 0 2 2 2 2 BNR repeat-like domain BNR_3 PF13859.4 T211905_2 - 0.0023 17.1 0.0 0.0034 16.6 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 T211905_2 - 0.0028 17.3 2.0 0.26 11.3 0.5 3.9 3 0 0 3 3 3 1 BNR/Asp-box repeat EHD_N PF16880.3 T177994_1 - 6.2e-16 57.9 1.0 1.3e-15 56.9 1.0 1.5 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.21 T177994_1 - 1.8e-12 47.5 0.0 5.1e-12 46.0 0.0 1.7 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.21 T177994_1 - 7.8e-07 29.0 0.0 1.3e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Rdx PF10262.7 T177994_1 - 1.7e-05 24.8 0.0 4.1e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Rdx family Nop53 PF07767.9 T177994_3 - 1.9e-99 333.6 20.6 2.3e-99 333.3 20.6 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Acyltransf_C PF16076.3 T227473_1 - 6.9e-25 86.9 0.2 1.2e-24 86.1 0.2 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.19 T227473_1 - 1.5e-13 50.4 0.0 2.6e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Alpha-amylase_C PF02806.16 T016347_1 - 3e-14 53.1 0.1 5.3e-14 52.3 0.1 1.4 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.22 T016347_1 - 1.1e-12 48.1 0.0 1.8e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain RRM_1 PF00076.20 T016347_3 - 6.2e-17 61.1 0.1 1.2e-07 31.3 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 T016347_3 - 0.12 11.9 0.0 4.2 6.9 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAP_assoc PF03828.17 T011048_1 - 9.3e-11 41.7 0.7 2e-10 40.6 0.0 2.0 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.21 T011048_1 - 1.2e-05 25.3 0.1 6.7e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.17 T011048_2 - 1.4e-15 57.1 0.2 2.7e-15 56.2 0.2 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase zf-CCHC PF00098.21 T011048_2 - 8.1e-08 31.9 12.6 0.00066 19.5 0.5 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.4 T011048_2 - 0.0017 17.9 13.6 0.17 11.6 6.8 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.4 T011048_2 - 1.5 8.6 6.1 1.6 8.5 1.9 2.7 2 0 0 2 2 2 0 Zinc knuckle Neur_chan_LBD PF02931.21 T255925_2 - 6.7e-26 90.9 0.6 9.9e-26 90.4 0.6 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 T255925_3 - 4.8e-17 62.7 1.1 7.9e-17 62.0 1.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 T140086_3 - 1.1e-63 214.5 0.0 1.5e-63 214.0 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 T140086_3 - 4.8e-56 190.4 0.0 6.9e-56 189.8 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Calpain_III PF01067.20 T032672_1 - 5.1e-52 175.8 0.0 8.8e-52 175.0 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III Peptidase_C2 PF00648.19 T032672_1 - 4.6e-39 134.0 0.1 6.9e-39 133.5 0.1 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease EF-hand_1 PF00036.30 T032672_1 - 9.9e-12 43.4 1.4 6.9e-05 22.0 0.2 4.2 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.4 T032672_1 - 1.1e-08 34.2 2.5 0.0014 18.3 0.0 4.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 T032672_1 - 1.8e-07 30.7 5.0 3.4e-06 26.6 0.4 3.2 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.4 T032672_1 - 0.00017 21.8 4.7 0.16 12.3 0.7 3.6 2 1 0 2 2 2 2 EF-hand domain pair Ndufs5 PF10200.7 T032672_1 - 0.0013 18.8 0.1 0.16 12.1 0.0 3.2 3 0 0 3 3 3 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa EF-hand_5 PF13202.4 T032672_1 - 0.0094 15.3 4.4 0.56 9.7 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.5 T032672_1 - 0.24 11.2 3.6 2.1 8.2 0.8 2.6 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand CLASP_N PF12348.6 T198148_2 - 6.7e-53 179.5 17.0 1.6e-39 135.7 0.6 5.2 6 0 0 6 6 6 2 CLASP N terminal HEAT PF02985.20 T198148_2 - 1.6e-15 55.7 11.6 2.6e-05 23.9 0.0 8.9 10 0 0 10 10 9 3 HEAT repeat Cnd1 PF12717.5 T198148_2 - 3.8e-08 33.4 2.9 0.0045 16.9 0.8 5.1 4 1 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 T198148_2 - 8.2e-08 32.4 2.8 0.066 13.6 0.0 5.6 5 0 0 5 5 5 1 HEAT-like repeat HEAT_2 PF13646.4 T198148_2 - 1.4e-07 31.7 6.8 0.18 12.1 0.0 6.9 5 2 4 10 10 10 4 HEAT repeats Sec7_N PF12783.5 T198148_2 - 1.9e-07 31.1 0.1 0.0077 16.1 0.0 4.3 3 0 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Vac14_Fab1_bd PF12755.5 T198148_2 - 2.3e-05 24.7 1.2 2.7 8.5 0.0 4.9 6 0 0 6 6 5 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.18 T198148_2 - 9.3e-05 21.0 3.2 2.5 6.4 0.0 4.9 4 2 0 6 6 6 2 Adaptin N terminal region RTP1_C1 PF10363.7 T198148_2 - 0.00056 19.9 2.4 0.71 9.9 0.3 4.5 4 1 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 ParcG PF10274.7 T198148_2 - 0.0048 16.9 2.0 0.067 13.2 0.2 3.5 2 1 1 3 3 3 1 Parkin co-regulated protein TFCD_C PF12612.6 T198148_2 - 0.0073 16.1 0.9 0.091 12.5 0.2 3.0 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal MMS19_N PF14500.4 T198148_2 - 0.012 15.1 2.8 1.4 8.2 0.1 3.8 4 0 0 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II TAN PF11640.6 T198148_2 - 0.08 13.0 5.0 0.19 11.8 0.1 3.6 4 0 0 4 4 4 0 Telomere-length maintenance and DNA damage repair Ipi1_N PF12333.6 T198148_2 - 3.9 8.0 5.9 3.6 8.2 0.1 3.7 4 0 0 4 4 3 0 Rix1 complex component involved in 60S ribosome maturation V-set PF07686.15 T230300_3 - 1.4e-16 60.5 0.1 1.8e-16 60.1 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T230300_3 - 1.7e-06 28.4 0.2 3.4e-06 27.4 0.2 1.5 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T230300_3 - 1.5e-05 25.0 0.1 2.6e-05 24.2 0.1 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T230300_3 - 0.0036 17.2 0.0 0.015 15.2 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 T230300_3 - 0.016 15.4 0.2 0.034 14.4 0.2 1.6 1 1 0 1 1 1 0 Immunoglobulin domain DUF3697 PF12478.6 T021584_3 - 6.1e-15 54.9 0.2 1.3e-14 53.9 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-associated protein 2 UBA_4 PF14555.4 T021584_3 - 0.00071 19.2 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain DUF1296 PF06972.9 T021584_3 - 0.043 13.8 0.1 0.1 12.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) Comm PF15957.3 T021584_3 - 0.08 13.2 0.2 0.25 11.5 0.2 1.8 1 0 0 1 1 1 0 Commissureless CUE PF02845.14 T021584_3 - 0.7 9.5 2.1 0.68 9.6 0.2 2.0 2 0 0 2 2 2 0 CUE domain RRM_1 PF00076.20 T061757_1 - 1.5e-31 107.9 0.1 5.5e-15 54.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 T061757_1 - 7.7e-06 25.6 3.0 7.7e-06 25.6 3.0 2.5 2 0 0 2 2 2 1 Zinc knuckle RRM_5 PF13893.4 T061757_1 - 7.9e-06 25.4 0.2 0.003 17.0 0.1 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T061757_1 - 0.0017 18.3 0.0 0.35 10.9 0.0 3.1 3 0 0 3 3 3 1 RNA recognition motif RRM_occluded PF16842.3 T061757_1 - 0.083 12.6 0.0 0.53 10.1 0.0 2.0 2 0 0 2 2 2 0 Occluded RNA-recognition motif Spectrin PF00435.19 T061757_3 - 8.5e-257 832.8 167.3 2.6e-19 69.5 0.4 17.7 18 0 0 18 18 18 17 Spectrin repeat CH PF00307.29 T061757_3 - 9.2e-48 160.8 0.9 1.4e-23 83.0 0.1 2.7 2 0 0 2 2 2 2 Calponin homology (CH) domain PH_9 PF15410.4 T061757_3 - 1.3e-18 67.4 0.0 3.4e-18 66.0 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 T061757_3 - 4.5e-11 43.0 0.0 1.4e-10 41.5 0.0 1.9 1 0 0 1 1 1 1 PH domain CAMSAP_CH PF11971.6 T061757_3 - 2.7e-05 23.8 0.2 0.00029 20.5 0.1 2.3 2 0 0 2 2 2 1 CAMSAP CH domain Miga PF10265.7 T367304_1 - 3.6e-213 709.3 0.0 8.2e-156 520.0 0.0 2.0 2 0 0 2 2 2 2 Mitoguardin MARVEL PF01284.21 T046866_3 - 1.4e-16 60.7 6.5 2.3e-16 60.0 6.5 1.4 1 0 0 1 1 1 1 Membrane-associating domain Med4 PF10018.7 T046866_3 - 0.068 12.7 3.7 0.11 12.0 3.7 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 TGF_beta PF00019.18 T080543_1 - 1.1e-27 96.8 0.1 2.2e-27 95.9 0.1 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain Anti-TRAP PF15777.3 T080543_1 - 0.48 10.3 3.6 3.1 7.7 0.1 3.2 3 0 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-C2H2 PF00096.24 T080543_3 - 1.1e-12 47.5 44.6 0.00096 19.4 0.6 7.2 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T080543_3 - 7.1e-08 32.4 10.4 1.3e-05 25.3 1.5 7.3 9 0 0 9 9 9 3 Zinc-finger double domain FOXP-CC PF16159.3 T080543_3 - 7.1e-07 29.6 18.6 0.00049 20.5 1.0 4.6 1 1 3 4 4 4 2 FOXP coiled-coil domain IL17 PF06083.9 T080543_3 - 0.011 16.1 0.1 0.044 14.1 0.1 2.1 1 0 0 1 1 1 0 Interleukin-17 zf-C2H2_4 PF13894.4 T080543_3 - 0.023 15.4 0.5 0.023 15.4 0.5 7.4 7 0 0 7 7 7 0 C2H2-type zinc finger IQ_SEC7_PH PF16453.3 T071170_1 - 8.3e-60 200.6 1.2 1.6e-59 199.7 1.2 1.5 1 0 0 1 1 1 1 PH domain Sec7 PF01369.18 T071170_1 - 7.8e-56 188.6 0.0 1.1e-55 188.0 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain SH3_1 PF00018.26 T052348_1 - 1.3e-10 40.5 0.0 2.8e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T052348_1 - 3.1e-07 30.0 0.1 8.7e-07 28.6 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 T052348_1 - 9.2e-06 25.1 0.0 2e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 T052348_1 - 0.024 14.8 0.4 0.071 13.3 0.1 2.0 2 0 0 2 2 2 0 Bacterial SH3 domain PTB PF08416.11 T052348_2 - 2.1e-48 163.7 2.3 2.9e-48 163.2 2.3 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID PF00640.21 T052348_2 - 2.4e-05 24.2 0.1 4.1e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Transmemb_17 PF09799.7 T052348_3 - 3.3e-29 101.5 9.9 4.6e-29 101.0 9.9 1.2 1 0 0 1 1 1 1 Predicted membrane protein Lig_chan PF00060.24 T369927_1 - 1.4e-38 131.9 0.1 2e-38 131.4 0.1 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 T369927_1 - 5.5e-29 100.6 0.0 5.3e-18 65.1 0.0 2.3 2 0 0 2 2 2 2 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 T369927_1 - 1.4e-18 67.0 0.0 5e-18 65.2 0.0 1.8 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 CaM_bdg_C0 PF10562.7 T369927_1 - 1.8e-13 50.2 3.9 3.2e-13 49.3 3.9 1.4 1 0 0 1 1 1 1 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit Ion_trans_2 PF07885.14 T369927_1 - 0.079 12.8 0.5 0.18 11.7 0.5 1.5 1 0 0 1 1 1 0 Ion channel Myosin_head PF00063.19 T167603_1 - 7.3e-248 824.1 0.0 8.7e-248 823.8 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) zf-C2H2_8 PF15909.3 T167603_1 - 6.5e-57 189.8 12.1 1.4e-56 188.7 12.1 1.6 1 0 0 1 1 1 1 C2H2-type zinc ribbon Myosin_TH1 PF06017.11 T167603_1 - 1.4e-51 174.7 0.0 2.2e-51 174.0 0.0 1.3 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Pep_M12B_propep PF01562.17 T167603_1 - 6.3e-31 107.3 0.0 1.1e-30 106.6 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.17 T167603_1 - 7.7e-23 81.3 0.0 1.2e-22 80.6 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease SH3_9 PF14604.4 T167603_1 - 1.1e-13 50.6 0.2 2.3e-13 49.6 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T167603_1 - 2.3e-13 49.4 0.2 6.2e-13 48.0 0.1 1.9 2 0 0 2 2 2 1 SH3 domain Reprolysin_5 PF13688.4 T167603_1 - 1.3e-12 48.2 0.2 2.2e-12 47.4 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 SH3_2 PF07653.15 T167603_1 - 5.3e-11 41.9 0.1 1.2e-10 40.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain Reprolysin_3 PF13582.4 T167603_1 - 1.6e-10 41.5 0.1 2.5e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T167603_1 - 4.6e-09 36.3 0.2 7.4e-09 35.6 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T167603_1 - 3.1e-06 26.9 0.1 5.8e-06 26.0 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like zf-H2C2_5 PF13909.4 T167603_1 - 0.03 14.0 1.8 0.044 13.4 0.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc-finger domain IQ PF00612.25 T167603_1 - 5.7 6.9 5.9 1.3 8.9 1.2 2.6 2 0 0 2 2 1 0 IQ calmodulin-binding motif zf-C2H2_6 PF13912.4 T167603_1 - 7.1 6.6 11.7 2 8.3 0.2 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger hSH3 PF14603.4 T167603_2 - 5.2e-30 103.7 0.0 8.4e-30 103.0 0.0 1.3 1 0 0 1 1 1 1 Helically-extended SH3 domain TSP_1 PF00090.17 T167603_2 - 1.7e-06 28.0 9.7 1.7e-06 28.0 9.7 2.8 2 0 0 2 2 2 1 Thrombospondin type 1 domain SH3_2 PF07653.15 T167603_2 - 0.0053 16.3 0.0 0.013 15.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain ADAM_spacer1 PF05986.12 T167603_3 - 8e-24 83.7 0.0 1.2e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 PLAC PF08686.9 T167603_3 - 2e-08 34.7 11.0 7.5e-08 32.8 11.0 2.1 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain TSP_1 PF00090.17 T167603_3 - 4.4e-07 29.9 54.8 0.0069 16.5 11.0 6.0 5 0 0 5 5 5 4 Thrombospondin type 1 domain Ion_trans PF00520.29 T017213_1 - 1.8e-48 164.8 11.2 3e-48 164.1 11.2 1.4 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 T017213_1 - 3.6e-28 97.6 0.1 6.9e-28 96.7 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 T017213_1 - 2.3e-13 49.8 4.7 2.3e-13 49.8 4.7 2.6 4 0 0 4 4 4 1 Ion channel PKD_channel PF08016.10 T017213_1 - 0.008 14.8 0.2 0.008 14.8 0.2 2.2 2 1 0 3 3 3 1 Polycystin cation channel SPRY PF00622.26 T032305_1 - 4.7e-12 46.0 0.0 8.6e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 T032305_1 - 8.1e-09 35.4 4.8 8.1e-09 35.4 4.8 3.2 2 0 0 2 2 2 1 B-box zinc finger zf-RING_UBOX PF13445.4 T032305_1 - 4.8e-08 32.8 0.6 2.3e-07 30.6 0.6 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 T032305_1 - 6.2e-07 29.1 1.2 2.2e-06 27.3 1.2 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T032305_1 - 6.3e-07 29.3 0.7 6.3e-07 29.3 0.7 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 T032305_1 - 9.7e-05 22.0 0.2 0.00038 20.1 0.2 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T032305_1 - 0.00011 22.0 0.8 0.00011 22.0 0.8 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 T032305_1 - 0.01 15.9 2.3 0.01 15.9 2.3 3.2 3 0 0 3 3 3 0 Ring finger domain PRY PF13765.4 T032305_2 - 6e-23 80.1 0.2 1.3e-22 79.0 0.2 1.6 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 T032305_2 - 4e-13 49.4 0.0 7.3e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 T032305_2 - 9.7e-13 47.9 10.8 3.1e-12 46.3 10.8 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 T032305_2 - 4.4e-11 42.3 8.5 1.7e-10 40.5 8.5 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T032305_2 - 9.5e-10 38.2 8.2 3.6e-09 36.3 8.2 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 T032305_2 - 4.2e-09 36.0 10.2 1.6e-08 34.1 10.2 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T032305_2 - 6.8e-07 28.9 7.6 3.9e-06 26.5 7.6 2.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 T032305_2 - 1.4e-06 28.2 0.0 1.4e-06 28.2 0.0 3.1 3 0 0 3 3 2 1 B-box zinc finger zf-RING_2 PF13639.4 T032305_2 - 3.6e-06 27.0 10.4 3.6e-06 27.0 10.4 2.8 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 T032305_2 - 4.9e-05 23.1 9.0 0.0002 21.1 9.0 2.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.4 T032305_2 - 0.0016 18.1 2.2 0.0042 16.8 2.2 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 T032305_2 - 0.073 13.1 4.5 0.21 11.6 4.5 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 T032305_2 - 0.13 12.1 10.8 0.065 13.0 7.7 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Patatin PF01734.20 T331057_2 - 2.7e-23 83.1 0.0 4.4e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase SMC_ScpB PF04079.14 T331057_2 - 0.097 12.1 0.2 0.24 10.9 0.2 1.6 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB Surp PF01805.18 T170802_2 - 5.6e-16 58.1 0.2 4.3e-10 39.3 0.2 2.6 2 0 0 2 2 2 2 Surp module G-patch PF01585.21 T170802_2 - 2e-13 49.9 0.8 2e-13 49.9 0.8 2.4 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.5 T170802_2 - 0.037 14.0 1.1 0.061 13.3 0.1 1.9 2 0 0 2 2 2 0 G-patch domain PPP1R32 PF15691.3 T059754_3 - 5e-177 589.1 2.3 2.3e-146 488.1 2.6 3.1 2 1 0 2 2 2 2 Protein phosphatase 1 regulatory subunit 32 NHR2 PF08788.9 T138356_1 - 1e-35 121.2 8.6 2.4e-35 120.0 8.6 1.7 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 T138356_1 - 4.2e-34 116.3 1.5 7.2e-34 115.6 1.5 1.4 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.16 T138356_1 - 2.8e-06 27.2 18.5 2.8e-06 27.2 18.5 2.6 2 0 0 2 2 2 1 MYND finger Efg1 PF10153.7 T138356_1 - 0.16 12.2 0.4 0.31 11.3 0.4 1.4 1 0 0 1 1 1 0 rRNA-processing protein Efg1 DnaJ PF00226.29 T222642_1 - 1.2e-25 89.2 2.7 1.9e-25 88.6 2.7 1.3 1 0 0 1 1 1 1 DnaJ domain TPD52 PF04201.13 T222642_3 - 6.4e-70 233.8 1.2 8.8e-70 233.4 1.2 1.2 1 0 0 1 1 1 1 Tumour protein D52 family Abhydrolase_1 PF00561.18 T222642_3 - 1.6e-08 34.4 0.1 2.6e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 T222642_3 - 1.4e-05 24.4 0.0 2.3e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.19 T222642_3 - 0.12 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Spc24 PF08286.9 T168442_1 - 5.6e-15 55.4 0.5 1e-14 54.5 0.1 1.6 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 Myosin_tail_1 PF01576.17 T168442_1 - 0.0023 15.7 12.4 0.0031 15.3 12.4 1.0 1 0 0 1 1 1 1 Myosin tail DUF489 PF04356.10 T168442_1 - 0.23 11.3 2.2 0.37 10.6 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) PilO PF04350.11 T168442_1 - 0.75 9.8 4.4 1.1 9.2 4.4 1.2 1 0 0 1 1 1 0 Pilus assembly protein, PilO DUF972 PF06156.11 T168442_1 - 0.76 10.3 3.9 1.5 9.4 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Lipoprotein_20 PF13942.4 T168442_1 - 1.9 8.3 8.4 2.9 7.6 8.4 1.2 1 0 0 1 1 1 0 YfhG lipoprotein Spc7 PF08317.9 T168442_1 - 6.9 5.3 11.6 9.9 4.8 11.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6 PF04111.10 T168442_1 - 9.3 5.4 10.8 14 4.8 10.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-4CXXC_R1 PF10497.7 T319758_3 - 1.4e-36 124.6 11.0 2.7e-36 123.6 11.0 1.5 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 SpoIIIAH PF12685.5 T319758_3 - 6.8 6.3 9.6 11 5.6 9.6 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Ras PF00071.20 T175659_1 - 3.3e-39 133.9 0.3 2.8e-21 75.7 0.2 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.11 T175659_1 - 7.6e-18 64.8 0.4 8.5e-16 58.1 0.4 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T175659_1 - 1.7e-05 24.2 0.1 0.0004 19.7 0.1 2.1 1 1 1 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 T175659_1 - 0.13 11.5 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region 2OG-FeII_Oxy_3 PF13640.4 T175659_3 - 7.3e-18 65.1 0.0 2.2e-17 63.6 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily SH3_2 PF07653.15 T175659_3 - 3e-09 36.3 0.0 5.5e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain 2OG-FeII_Oxy_4 PF13661.4 T175659_3 - 1.4e-08 35.1 0.0 2.9e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Calc_CGRP_IAPP PF00214.17 T054702_2 - 1.3e-28 99.7 0.0 2.1e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family A_deaminase PF00962.20 T054702_3 - 5.2e-136 453.2 0.0 8.9e-136 452.4 0.0 1.4 1 1 0 1 1 1 1 Adenosine/AMP deaminase DUF773 PF05600.10 T149559_3 - 2e-188 627.2 0.8 2.4e-188 626.9 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF773) LRR_4 PF12799.5 T063908_1 - 5.6e-09 36.0 7.2 0.0032 17.7 0.1 3.7 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T063908_1 - 8.2e-09 35.0 6.8 0.00089 18.8 0.3 4.0 3 1 0 3 3 3 3 Leucine rich repeat LRR_9 PF14580.4 T063908_1 - 0.12 11.7 0.7 0.92 8.8 0.6 2.1 1 1 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.4 T063908_1 - 0.45 10.6 3.1 26 5.1 0.0 4.0 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.31 T063908_1 - 1.7 9.3 6.5 1.5e+02 3.4 0.1 5.5 5 0 0 5 5 5 0 Leucine Rich Repeat Homeobox PF00046.27 T030871_2 - 2.5e-14 52.7 1.8 3.1e-06 26.8 0.0 2.5 2 0 0 2 2 2 2 Homeobox domain GPS2_interact PF15784.3 T088756_2 - 2.1e-38 130.7 7.2 2.1e-38 130.7 7.2 4.6 3 1 0 3 3 3 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 T088756_2 - 7.2e-19 67.6 0.5 1.9e-11 43.8 0.2 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Spt20 PF12090.6 T088756_2 - 0.01 15.3 17.4 0.036 13.6 17.4 2.0 1 0 0 1 1 1 0 Spt20 family Myb_DNA-bind_6 PF13921.4 T088756_2 - 0.013 15.6 0.5 0.013 15.6 0.5 3.0 3 0 0 3 3 3 0 Myb-like DNA-binding domain Serinc PF03348.13 T088756_2 - 0.6 8.9 3.5 1 8.1 3.5 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4518 PF15008.4 T088756_2 - 3.7 6.5 13.6 0.45 9.5 7.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) TAF1D PF15333.4 T088756_3 - 0.91 9.1 7.7 1.9 8.1 7.7 1.4 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D SET PF00856.26 T088402_3 - 1.7e-17 64.2 1.2 1e-16 61.7 0.1 2.3 2 0 0 2 2 2 1 SET domain K_channel_TID PF07941.9 T088402_3 - 3.9 7.9 10.1 31 5.0 0.2 2.9 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain A_deamin PF02137.16 T137177_1 - 5.4e-25 88.4 0.0 7.4e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 T137177_1 - 1.9e-05 25.1 0.0 3.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif A_deamin PF02137.16 T137177_2 - 8e-21 74.7 0.0 1.1e-20 74.3 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain PHD PF00628.27 T330620_2 - 1.5e-09 37.5 12.5 4.5e-09 35.9 12.5 1.9 1 0 0 1 1 1 1 PHD-finger SET PF00856.26 T330620_2 - 3.5e-08 33.9 0.1 3.5e-08 33.9 0.1 2.3 2 0 0 2 2 2 1 SET domain PHD_2 PF13831.4 T330620_2 - 0.0013 18.1 8.1 0.004 16.5 8.1 1.9 1 0 0 1 1 1 1 PHD-finger WBS_methylT PF12589.6 T326318_1 - 3.8e-11 43.5 7.7 6.2e-11 42.8 7.7 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.10 T326318_3 - 8.7e-10 39.0 0.0 1.6e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 T326318_3 - 1.5e-09 38.3 0.0 2.8e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 T326318_3 - 0.0015 18.3 0.0 0.0025 17.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 T326318_3 - 0.0017 18.9 0.0 0.0031 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T326318_3 - 0.0019 17.9 0.0 0.0032 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DIL PF01843.17 T178357_1 - 2.2e-22 79.2 0.0 4.3e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 DIL domain RA PF00788.21 T178357_1 - 8.9e-10 39.0 0.0 1.6e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Glyco_transf_11 PF01531.14 T178357_2 - 3.9e-137 456.3 0.0 5e-137 455.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 11 IZUMO PF15005.4 T178357_3 - 6.1e-57 192.1 2.9 8.5e-57 191.7 2.9 1.2 1 0 0 1 1 1 1 Izumo sperm-egg fusion, Ig domain-associated Izumo-Ig PF16706.3 T178357_3 - 7.1e-42 141.2 0.0 1.1e-41 140.7 0.0 1.3 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain RabGAP-TBC PF00566.16 T363620_3 - 3.9e-52 176.9 0.3 5.8e-52 176.3 0.3 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH PF00169.27 T363620_3 - 1.5e-08 34.9 0.1 2.9e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 T363620_3 - 0.0015 18.6 0.0 0.0028 17.8 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 T363620_3 - 0.014 15.7 0.1 0.044 14.1 0.1 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain Fib_alpha PF08702.8 T363620_3 - 9.8 6.2 15.9 2.6 8.1 11.4 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Bradykinin PF06753.10 T191354_2 - 0.12 12.0 2.6 0.49 10.0 2.6 2.1 1 0 0 1 1 1 0 Bradykinin HECT PF00632.23 T086130_1 - 9.4e-15 54.7 0.0 1.3e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HECT PF00632.23 T086130_3 - 1.6e-74 251.0 0.0 2.8e-74 250.3 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.25 T086130_3 - 0.00013 21.3 0.4 0.00066 19.1 0.4 2.3 1 0 0 1 1 1 1 IQ calmodulin-binding motif EAL PF00563.18 T086130_3 - 0.62 9.4 2.2 1.7 8.0 0.1 2.1 2 0 0 2 2 2 0 EAL domain zf-H2C2_2 PF13465.4 T090539_1 - 3.1e-67 220.0 82.9 8.9e-08 32.1 0.5 13.4 14 0 0 14 14 14 10 Zinc-finger double domain zf-C2H2 PF00096.24 T090539_1 - 5.1e-43 143.0 85.7 5.8e-07 29.5 0.4 12.6 12 0 0 12 12 12 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T090539_1 - 1.1e-20 72.4 75.2 0.015 16.0 0.2 12.3 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T090539_1 - 4.8e-18 64.5 67.9 0.0025 17.6 0.5 11.5 11 0 0 11 11 11 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T090539_1 - 1.8e-06 27.8 45.3 0.053 13.5 1.6 7.6 2 1 8 10 10 10 7 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T090539_1 - 0.00075 19.6 51.3 0.72 10.1 0.9 10.6 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 T090539_1 - 4 7.4 46.0 33 4.5 0.3 11.0 11 0 0 11 11 11 0 XPA protein N-terminal PknG_rubred PF16919.3 T090539_1 - 4.6 7.2 17.1 0.23 11.4 0.2 4.0 2 1 1 4 4 4 0 Protein kinase G rubredoxin domain KRAB PF01352.25 T090539_3 - 2.8e-23 81.2 0.1 5.4e-23 80.3 0.1 1.4 1 0 0 1 1 1 1 KRAB box FYRN PF05964.12 T069419_2 - 6.1e-23 80.3 0.2 1.2e-22 79.3 0.2 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.12 T069419_2 - 4.3e-18 65.1 0.0 7.2e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 F/Y rich C-terminus Innexin PF00876.16 T069419_3 - 3.9e-08 32.9 0.1 6.6e-08 32.1 0.1 1.2 1 0 0 1 1 1 1 Innexin ADH_zinc_N PF00107.24 T268611_3 - 9.5e-24 83.6 0.2 1.4e-23 83.0 0.2 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 T268611_3 - 4.9e-21 74.5 0.1 7.9e-21 73.9 0.1 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 T268611_3 - 0.0015 19.4 0.0 0.0029 18.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 T268611_3 - 0.027 13.9 0.1 0.041 13.3 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glu_dehyd_C PF16912.3 T268611_3 - 0.095 12.0 0.1 0.3 10.4 0.1 1.7 1 1 0 1 1 1 0 Glucose dehydrogenase C-terminus zf-C4 PF00105.16 T235442_1 - 6.5e-27 93.7 16.1 6.5e-27 93.7 16.1 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 T235442_2 - 1.1e-12 47.8 0.1 1.9e-12 47.1 0.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor ING PF12998.5 T072574_2 - 1.9e-31 108.5 3.7 1.9e-31 108.5 3.7 1.5 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.27 T072574_2 - 2.6e-05 23.9 7.6 2.6e-05 23.9 7.6 2.0 2 0 0 2 2 2 1 PHD-finger Spc7 PF08317.9 T072574_2 - 0.015 14.1 8.1 0.021 13.6 8.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein zf-HC5HC2H PF13771.4 T072574_2 - 0.055 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain FlxA PF14282.4 T072574_2 - 1.2 9.1 5.4 2.2 8.2 5.4 1.5 1 0 0 1 1 1 0 FlxA-like protein PBP_sp32 PF07222.10 T072574_3 - 3.4e-52 177.2 13.4 6.2e-52 176.4 13.4 1.4 1 0 0 1 1 1 1 Proacrosin binding protein sp32 Kazal_2 PF07648.13 T072574_3 - 0.0026 17.8 8.3 0.011 15.8 0.4 2.7 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain TFIIF_alpha PF05793.10 T072574_3 - 0.5 8.8 15.9 0.7 8.3 15.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Plasmodium_Vir PF05795.9 T072574_3 - 1.4 8.1 8.9 2.1 7.5 8.9 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DDHD PF02862.15 T072574_3 - 1.8 8.5 6.3 2.9 7.8 6.3 1.2 1 0 0 1 1 1 0 DDHD domain Kazal_1 PF00050.19 T072574_3 - 4.1 7.4 9.5 0.19 11.6 0.6 2.5 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain MORN PF02493.18 T346082_1 - 5.6e-32 107.6 74.8 1e-07 31.3 0.7 8.7 8 0 0 8 8 8 8 MORN repeat Alanine_zipper PF11839.6 T346082_1 - 3.1 8.0 16.2 7 6.9 16.2 1.5 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein LIM PF00412.20 T334874_3 - 1.6e-30 104.9 43.3 8.8e-14 51.3 4.8 3.6 4 0 0 4 4 4 3 LIM domain zf-dskA_traR PF01258.15 T334874_3 - 0.00016 21.4 1.4 0.00016 21.4 1.4 5.4 5 1 1 6 6 6 1 Prokaryotic dksA/traR C4-type zinc finger Iso_dh PF00180.18 T212715_1 - 1.9e-59 201.5 0.2 3.3e-59 200.7 0.0 1.4 2 0 0 2 2 2 1 Isocitrate/isopropylmalate dehydrogenase Iso_dh PF00180.18 T212715_3 - 8.1e-07 28.4 0.0 1e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase AAA_3 PF07726.9 T212715_3 - 0.062 13.0 0.0 0.092 12.5 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) cNMP_binding PF00027.27 T077675_1 - 3.1e-16 59.0 0.0 6.3e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain RasGEF_N PF00618.18 T077675_1 - 1.6e-15 57.1 0.0 2.5e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 RasGEF N-terminal motif DEP PF00610.19 T077675_1 - 4.5e-14 52.1 0.1 7.7e-14 51.4 0.1 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RasGEF PF00617.17 T077675_2 - 1.1e-42 146.0 0.0 1.5e-42 145.6 0.0 1.2 1 0 0 1 1 1 1 RasGEF domain Toxin_35 PF10530.7 T077675_3 - 2.3 8.1 5.6 0.6 10.0 0.9 2.4 2 0 0 2 2 2 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold zf-H2C2_2 PF13465.4 T027618_3 - 3e-14 52.6 25.9 6e-06 26.3 0.2 5.2 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 T027618_3 - 3.5e-09 36.5 33.5 0.011 16.1 0.8 5.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T027618_3 - 2.5e-07 30.8 32.4 0.029 15.0 3.6 5.5 4 0 0 4 4 4 4 C2H2-type zinc finger GAGA PF09237.9 T027618_3 - 0.2 11.4 2.1 0.45 10.2 0.7 2.3 2 0 0 2 2 2 0 GAGA factor KRTDAP PF15200.4 T173693_2 - 4.7e-41 138.3 12.2 5.3e-38 128.5 0.2 3.3 2 1 1 3 3 3 3 Keratinocyte differentiation-associated Integrin_alpha2 PF08441.10 T037671_3 - 3.2e-125 418.5 0.1 4e-125 418.2 0.1 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 T037671_3 - 2.8e-16 59.2 19.7 2.5e-09 37.0 0.1 5.2 6 0 0 6 6 6 3 FG-GAP repeat VCBS PF13517.4 T037671_3 - 1.1e-06 29.0 9.5 1.1e-05 25.8 1.3 3.1 1 1 3 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 T037671_3 - 5e-05 22.8 0.3 0.00012 21.7 0.3 1.7 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region LYRIC PF15686.3 T037671_3 - 0.014 14.9 0.1 0.021 14.3 0.1 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family SWIB PF02201.16 T152184_3 - 1.9e-18 65.9 0.0 3.4e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain SEA PF01390.18 T021928_1 - 1.6e-05 25.0 0.1 2.5e-05 24.4 0.1 1.2 1 0 0 1 1 1 1 SEA domain TSP_C PF05735.10 T021928_3 - 1.5e-95 318.6 0.4 1.9e-95 318.3 0.4 1.1 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 T021928_3 - 4.8e-55 182.8 134.6 6.8e-13 47.9 11.9 9.2 7 2 1 8 8 8 7 Thrombospondin type 3 repeat COMP PF11598.6 T021928_3 - 6.1e-19 68.1 4.3 1.2e-18 67.1 4.3 1.5 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein EGF_CA PF07645.13 T021928_3 - 2.8e-10 40.1 19.6 1.4e-06 28.2 2.1 5.1 4 0 0 4 4 4 2 Calcium-binding EGF domain cEGF PF12662.5 T021928_3 - 1.9e-05 24.4 25.1 0.0005 19.8 1.6 4.7 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_3 PF12947.5 T021928_3 - 0.0007 19.6 6.8 0.0007 19.6 6.8 6.0 5 1 0 5 5 5 3 EGF domain Pkinase_Tyr PF07714.15 T258150_1 - 1.6e-86 289.7 0.0 2e-86 289.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T258150_1 - 3.3e-41 141.3 0.0 4.6e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 T258150_1 - 0.00024 20.4 0.0 0.00037 19.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like GTPase_binding PF09027.8 T258150_3 - 4.4e-44 148.2 0.6 4.4e-44 148.2 0.6 1.9 2 0 0 2 2 2 1 GTPase binding Inhibitor_Mig-6 PF11555.6 T258150_3 - 4.1e-25 87.5 19.1 4.1e-25 87.5 19.1 4.6 3 1 0 3 3 3 1 EGFR receptor inhibitor Mig-6 UBA_4 PF14555.4 T258150_3 - 2e-06 27.4 0.1 0.081 12.6 0.0 2.3 2 0 0 2 2 2 2 UBA-like domain SH3_9 PF14604.4 T258150_3 - 0.0045 16.7 0.1 0.009 15.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain UBA PF00627.29 T258150_3 - 0.011 15.5 0.0 0.026 14.3 0.0 1.6 2 0 0 2 2 2 0 UBA/TS-N domain ENOD40 PF08247.9 T340421_1 - 4.3 7.4 9.2 4.8 7.3 1.4 3.3 2 0 0 2 2 2 0 ENOD40 protein ENOD40 PF08247.9 T340421_2 - 0.19 11.6 9.5 4.8 7.3 1.4 3.3 2 0 0 2 2 2 0 ENOD40 protein ENOD40 PF08247.9 T340421_3 - 0.28 11.1 9.5 4.8 7.3 1.4 3.0 2 0 0 2 2 2 0 ENOD40 protein TPR_12 PF13424.4 T280849_2 - 0.00025 21.2 11.9 0.0011 19.0 1.2 4.0 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.4 T280849_2 - 0.12 12.7 0.1 0.37 11.2 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.26 T280849_2 - 0.66 9.8 6.0 54 3.7 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.15 T280849_2 - 9.6 6.5 10.0 51 4.2 0.3 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Forkhead PF00250.16 T086080_3 - 9.4e-31 105.9 0.1 1.6e-30 105.2 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain Pkinase PF00069.23 T382225_3 - 2.5e-74 249.8 0.0 3.2e-74 249.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T382225_3 - 3.3e-34 118.2 0.0 4.1e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T382225_3 - 4.2e-06 26.2 0.0 5.7e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 T382225_3 - 0.0022 17.2 0.0 0.0038 16.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 T382225_3 - 0.081 12.7 0.1 2 8.2 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.20 T382225_3 - 0.23 10.9 0.0 0.36 10.3 0.0 1.2 1 0 0 1 1 1 0 RIO1 family zf-DHHC PF01529.18 T241412_2 - 1.6e-35 122.0 10.7 4.9e-35 120.4 10.7 1.9 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF898 PF05987.11 T241412_2 - 0.078 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Amidohydro_1 PF01979.18 T360228_2 - 7.1e-74 249.0 0.0 8.9e-74 248.7 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 T360228_2 - 2.1e-09 37.3 0.0 3.4e-07 30.0 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family RHIM PF12721.5 T101821_1 - 6.3e-19 68.1 3.2 6.3e-19 68.1 3.2 3.2 3 0 0 3 3 3 1 RIP homotypic interaction motif Pkinase_Tyr PF07714.15 T101821_1 - 0.007 15.5 0.0 0.01 15.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Guanylate_cyc PF00211.18 T101821_2 - 6.4e-112 371.3 0.2 6.5e-62 208.3 0.0 3.2 3 0 0 3 3 3 3 Adenylate and Guanylate cyclase catalytic domain Pkinase PF00069.23 T101821_2 - 2.4e-37 128.6 0.0 4e-37 127.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T101821_2 - 7.5e-32 110.5 0.0 2.1e-31 109.0 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase DUF1053 PF06327.12 T101821_2 - 2.9e-31 107.9 0.2 5.1e-31 107.2 0.2 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) AC_N PF16214.3 T101821_2 - 8e-18 64.6 0.0 1.8e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Adenylyl cyclase N-terminal extracellular and transmembrane region APH PF01636.21 T101821_2 - 0.0058 16.4 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family CD52 PF15116.4 T101821_2 - 0.67 9.9 0.0 0.67 9.9 0.0 3.1 3 0 0 3 3 3 0 CAMPATH-1 antigen C2 PF00168.28 T041198_2 - 2.6e-26 91.8 0.6 8.7e-15 54.7 0.0 2.3 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.4 T041198_2 - 0.015 14.7 0.3 0.041 13.3 0.1 1.7 2 0 0 2 2 2 0 CEP76 C2 domain Tom37 PF10568.7 T284832_1 - 8.8e-37 126.1 0.0 1.3e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.2 T284832_1 - 3.3e-22 77.9 0.3 8.4e-22 76.6 0.3 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.2 T284832_1 - 8.7e-15 55.2 0.0 1.4e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.4 T284832_1 - 3.9e-06 26.6 0.0 9.6e-06 25.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain FAM75 PF14650.4 T284832_1 - 0.069 12.6 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 FAM75 family FlaC_arch PF05377.9 T195086_1 - 0.00026 21.2 2.1 0.00026 21.2 2.1 1.9 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) IncA PF04156.12 T195086_1 - 0.0051 16.5 3.6 0.0072 16.0 3.6 1.2 1 0 0 1 1 1 1 IncA protein Spc7 PF08317.9 T195086_1 - 0.37 9.5 9.4 0.52 9.0 9.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6 PF04111.10 T195086_1 - 2.5 7.3 11.1 3.5 6.8 11.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Takusan PF04822.11 T195086_2 - 0.00096 18.9 4.6 0.00096 18.9 4.6 2.9 3 0 0 3 3 3 1 Takusan DUF1664 PF07889.10 T195086_2 - 0.022 14.6 22.1 0.0094 15.8 6.4 3.4 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Pox_A3L PF05288.9 T195086_2 - 0.054 13.4 0.2 0.14 12.0 0.2 1.7 1 0 0 1 1 1 0 Poxvirus A3L Protein GAS PF13851.4 T195086_2 - 0.44 9.8 34.9 0.0064 15.8 4.3 3.3 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF16 PF01519.14 T195086_2 - 7.5 7.0 18.9 0.42 11.0 3.8 2.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 Myosin_tail_1 PF01576.17 T195086_3 - 0.0066 14.2 47.6 0.01 13.6 47.6 1.1 1 0 0 1 1 1 1 Myosin tail ERM PF00769.17 T195086_3 - 0.011 15.4 52.1 0.047 13.4 13.8 2.5 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Fez1 PF06818.13 T195086_3 - 0.1 12.9 43.9 3.5 7.9 22.5 2.3 1 1 1 2 2 2 0 Fez1 DUF4201 PF13870.4 T195086_3 - 1.8 8.0 48.0 0.03 13.8 35.1 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Snapin_Pallidin PF14712.4 T195086_3 - 3.1 8.2 20.7 0.85 10.0 9.5 2.7 2 0 0 2 2 2 0 Snapin/Pallidin CALCOCO1 PF07888.9 T195086_3 - 4.1 5.7 48.3 47 2.2 48.1 1.8 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Transmemb_17 PF09799.7 T059727_1 - 1.1e-31 109.4 14.5 2.5e-31 108.3 14.5 1.6 1 0 0 1 1 1 1 Predicted membrane protein RVT_1 PF00078.25 T059727_1 - 0.0062 15.9 0.0 0.01 15.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MM_CoA_mutase PF01642.20 T304861_1 - 1.5e-235 782.5 0.0 1.7e-235 782.3 0.0 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.17 T304861_1 - 2.4e-14 53.3 0.1 6e-14 52.0 0.1 1.7 1 0 0 1 1 1 1 B12 binding domain DMRT-like PF15791.3 T176078_1 - 4e-52 175.5 8.4 4e-52 175.5 8.4 1.9 2 0 0 2 2 2 1 Doublesex-and mab-3-related transcription factor C1 and C2 DM PF00751.16 T176078_1 - 6.5e-20 70.6 10.2 6.5e-20 70.6 10.2 1.9 2 0 0 2 2 2 1 DM DNA binding domain VWC PF00093.16 T187656_1 - 5.1e-33 113.0 126.0 8.5e-10 38.7 13.6 16.2 11 2 5 16 16 16 6 von Willebrand factor type C domain Antistasin PF02822.12 T187656_1 - 1.5e-14 54.2 62.8 4.1e-07 30.4 9.4 12.1 14 0 0 14 14 14 4 Antistasin family Ras PF00071.20 T210559_3 - 2.2e-33 115.0 0.1 3.4e-18 65.6 0.1 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.11 T210559_3 - 3.4e-11 43.3 0.0 9.6e-09 35.4 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T210559_3 - 0.063 12.6 0.9 0.88 8.9 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family Aldo_ket_red PF00248.19 T004677_2 - 5.2e-86 288.3 0.0 3.3e-48 164.2 0.0 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family DUF903 PF06004.10 T004677_2 - 0.4 10.4 1.3 24 4.8 0.1 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF903) Neogenin_C PF06583.10 T119247_1 - 7.1e-119 396.8 24.2 1.3e-118 396.0 24.2 1.5 1 0 0 1 1 1 1 Neogenin C-terminus fn3 PF00041.19 T119247_1 - 8.6e-83 272.7 26.7 1.4e-17 63.7 0.8 6.4 6 0 0 6 6 6 6 Fibronectin type III domain I-set PF07679.14 T119247_1 - 1.5e-57 191.5 0.0 2e-16 59.7 0.0 6.4 7 0 0 7 7 6 4 Immunoglobulin I-set domain Ig_3 PF13927.4 T119247_1 - 3.2e-52 174.9 0.2 9.5e-14 51.6 0.0 6.3 6 0 0 6 6 5 4 Immunoglobulin domain Ig_2 PF13895.4 T119247_1 - 3.1e-41 139.4 0.0 2.7e-10 40.3 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 T119247_1 - 1.6e-32 111.4 0.0 1.1e-06 28.6 0.0 5.6 5 0 0 5 5 5 4 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 T119247_1 - 5.9e-23 81.1 21.8 0.00026 21.3 1.6 6.9 6 0 0 6 6 6 5 Purple acid Phosphatase, N-terminal domain V-set PF07686.15 T119247_1 - 1.6e-16 60.3 3.9 3.1e-05 24.0 0.0 8.7 5 4 2 7 7 7 2 Immunoglobulin V-set domain Interfer-bind PF09294.8 T119247_1 - 3.9e-13 49.5 0.1 0.086 13.0 0.0 5.6 5 0 0 5 5 5 4 Interferon-alpha/beta receptor, fibronectin type III Ig_5 PF16681.3 T119247_1 - 2.9e-10 40.3 0.0 0.0042 17.4 0.0 4.4 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 T119247_1 - 2.9e-10 39.9 0.0 0.0073 16.2 0.0 4.2 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain DUF2369 PF10179.7 T119247_1 - 2.5e-08 34.1 0.0 3 8.3 0.0 6.2 6 0 0 6 6 6 1 Uncharacterised conserved protein (DUF2369) fn3_4 PF16794.3 T119247_1 - 1.2e-06 28.2 2.8 1.9 8.3 0.1 5.4 5 0 0 5 5 5 1 Fibronectin-III type domain fn3_2 PF16893.3 T119247_1 - 2.1e-06 27.6 0.0 0.029 14.4 0.0 4.0 4 0 0 4 4 4 1 Fibronectin type III domain Ig_4 PF16680.3 T119247_1 - 0.00016 21.8 0.0 1.1 9.5 0.0 4.3 4 1 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain DUF4959 PF16323.3 T119247_1 - 0.0002 21.5 3.7 0.59 10.4 0.1 3.7 4 0 0 4 4 3 2 Domain of unknown function (DUF4959) EphA2_TM PF14575.4 T119247_1 - 0.0021 18.7 0.5 0.0051 17.5 0.5 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.4 T119247_1 - 0.0073 16.1 0.0 0.0073 16.1 0.0 1.9 2 0 0 2 2 1 1 TMEM154 protein family Herpes_gE PF02480.14 T119247_1 - 0.0096 14.6 0.0 4.5 5.8 0.0 3.3 4 0 0 4 4 4 1 Alphaherpesvirus glycoprotein E SusE PF14292.4 T119247_1 - 0.018 15.3 0.7 0.61 10.4 0.1 3.4 4 0 0 4 4 4 0 SusE outer membrane protein Izumo-Ig PF16706.3 T119247_1 - 0.046 13.6 0.0 3.7 7.5 0.0 3.6 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain Herpes_UL74 PF07982.10 T119247_1 - 0.11 11.2 1.5 0.18 10.6 1.5 1.2 1 0 0 1 1 1 0 Herpes UL74 glycoproteins Shisa PF13908.4 T119247_1 - 0.19 11.8 1.8 0.25 11.4 0.0 2.1 2 0 0 2 2 1 0 Wnt and FGF inhibitory regulator F5_F8_type_C PF00754.23 T119247_1 - 0.34 10.9 2.3 3.1 7.8 0.1 2.9 3 0 0 3 3 3 0 F5/8 type C domain STAT_bind PF02864.13 T147727_1 - 1.7e-76 257.3 0.0 1.7e-76 257.3 0.0 1.8 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 T147727_1 - 1.2e-55 188.1 18.5 2.1e-55 187.2 18.5 1.4 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT_int PF02865.15 T147727_1 - 2.4e-37 128.0 7.9 2.4e-37 128.0 7.9 2.7 2 1 0 2 2 2 1 STAT protein, protein interaction domain SH2 PF00017.22 T147727_1 - 5.2e-13 48.7 0.0 1.1e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 SH2 domain E2R135 PF11570.6 T147727_1 - 0.28 11.3 1.4 0.54 10.4 1.4 1.3 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 Syntaxin-6_N PF09177.9 T147727_1 - 1.4 9.4 6.6 0.25 11.8 0.6 2.5 2 1 1 3 3 3 0 Syntaxin 6, N-terminal YojJ PF10372.7 T147727_1 - 1.8 8.6 7.1 2.8 8.0 0.4 2.5 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Fib_alpha PF08702.8 T147727_1 - 4.6 7.3 12.4 1.5 8.9 7.5 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FSA_C PF10479.7 T270696_2 - 5.2e-160 533.8 16.4 1.1e-127 426.9 3.1 2.8 2 1 1 3 3 3 2 Fragile site-associated protein C-terminus Thioredoxin_8 PF13905.4 T361910_1 - 1.2e-25 89.5 0.0 7.3e-25 87.0 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like Caldesmon PF02029.13 T027808_2 - 6.7e-14 51.4 35.6 5.4e-08 31.9 1.8 2.1 2 0 0 2 2 2 2 Caldesmon Troponin PF00992.18 T027808_3 - 8.7e-33 113.3 50.3 1e-30 106.6 36.6 3.2 2 1 1 3 3 3 2 Troponin DUF1800 PF08811.9 T027808_3 - 0.37 9.6 5.7 0.59 8.9 5.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) p450 PF00067.20 T329264_2 - 8.5e-87 291.7 0.2 1e-86 291.4 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pacifastin_I PF05375.11 T329264_2 - 1.3 8.6 6.7 0.27 10.9 2.7 1.9 2 0 0 2 2 2 0 Pacifastin inhibitor (LCMII) PRY PF13765.4 T295318_1 - 3.6e-13 48.8 0.0 9.4e-13 47.4 0.0 1.8 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 T295318_1 - 8.4e-10 38.7 0.0 2e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 SPRY domain V-set PF07686.15 T295318_3 - 1.4e-10 41.2 0.0 3.6e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T295318_3 - 0.0041 17.6 0.0 0.056 13.9 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 T295318_3 - 0.061 13.3 0.0 0.48 10.4 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin I-set domain TEA PF01285.16 T071785_2 - 8.9e-26 90.9 0.1 1.4e-25 90.2 0.1 1.2 1 0 0 1 1 1 1 TEA/ATTS domain family Kelch_1 PF01344.23 T028180_1 - 0.00015 21.1 0.1 0.00048 19.5 0.1 1.9 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.23 T028180_2 - 3.1e-45 151.4 7.1 3.1e-12 45.7 0.2 4.5 4 0 0 4 4 4 4 Kelch motif BACK PF07707.13 T028180_2 - 4.5e-33 113.3 0.3 7e-33 112.7 0.3 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 T028180_2 - 9.8e-31 106.1 0.6 1.6e-30 105.4 0.6 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.4 T028180_2 - 7.9e-23 79.8 6.1 6.5e-05 22.9 0.1 4.7 2 2 2 4 4 4 4 Kelch motif Kelch_2 PF07646.13 T028180_2 - 1.5e-13 50.0 1.6 0.016 15.0 0.0 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.4 T028180_2 - 2e-11 43.7 1.8 1.1e-05 25.4 0.1 4.4 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.4 T028180_2 - 4.2e-11 42.5 1.5 0.014 15.2 0.0 4.5 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.4 T028180_2 - 1.9e-05 24.4 4.6 0.35 10.8 0.1 3.8 4 0 0 4 4 4 3 Kelch motif Mss4 PF04421.11 T028180_3 - 5.8e-31 106.4 0.0 8.8e-31 105.8 0.0 1.3 1 0 0 1 1 1 1 Mss4 protein zf-H2C2_2 PF13465.4 T171958_1 - 3.6e-77 251.5 144.5 2.3e-08 34.0 0.9 17.5 18 0 0 18 18 18 14 Zinc-finger double domain zf-C2H2 PF00096.24 T171958_1 - 3.5e-66 216.0 121.3 6.4e-06 26.2 0.6 17.0 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 T171958_1 - 8.6e-28 95.6 94.3 0.0021 17.8 0.5 15.1 14 0 0 14 14 14 14 C2H2-type zinc finger zf-C2H2_4 PF13894.4 T171958_1 - 2.2e-25 87.0 118.3 0.053 14.2 0.5 17.1 16 0 0 16 16 16 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T171958_1 - 1.7e-14 53.5 72.3 0.11 12.7 0.2 15.0 14 0 0 14 14 14 8 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 T171958_1 - 1e-12 47.7 70.5 0.99 9.4 0.2 14.7 14 0 0 14 14 14 10 XPA protein N-terminal Zn-ribbon_8 PF09723.8 T171958_1 - 2.5e-09 37.0 85.9 0.0035 17.3 2.4 11.2 6 5 4 11 11 11 8 Zinc ribbon domain SprT-like PF10263.7 T171958_1 - 6.6e-05 22.7 81.5 0.043 13.5 8.1 6.9 1 1 5 6 6 5 5 SprT-like family zinc_ribbon_15 PF17032.3 T171958_1 - 0.015 15.9 76.5 1.4 9.6 3.1 8.1 2 1 4 7 7 7 0 zinc-ribbon family GAGA PF09237.9 T171958_1 - 1.8 8.3 11.1 16 5.2 0.2 5.0 5 0 0 5 5 5 0 GAGA factor ADK_lid PF05191.12 T171958_1 - 5.7 6.9 49.7 0.36 10.7 1.4 7.8 5 2 1 6 6 6 0 Adenylate kinase, active site lid PDT PF00800.16 T171958_2 - 0.041 13.6 0.8 8.5 6.0 0.0 3.6 4 1 2 6 6 6 0 Prephenate dehydratase PDDEXK_10 PF07788.9 T171958_2 - 0.15 11.9 0.0 3.4e+02 1.1 0.0 5.1 6 1 1 7 7 7 0 PD-(D/E)XK nuclease superfamily KRAB PF01352.25 T171958_3 - 2e-22 78.4 0.2 3.5e-22 77.6 0.2 1.4 1 0 0 1 1 1 1 KRAB box Ribosomal_S18 PF01084.18 T300498_1 - 1e-13 51.1 0.1 2.4e-13 49.9 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S18 DUF2358 PF10184.7 T300498_2 - 3.2e-32 111.0 1.2 4.7e-32 110.5 1.2 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) Acetyltransf_16 PF05301.9 T300498_3 - 1.5e-75 252.6 0.0 2.1e-75 252.2 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.5 T300498_3 - 0.035 14.4 0.0 0.067 13.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 T300498_3 - 0.082 13.0 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family ANAPC4_WD40 PF12894.5 T125025_2 - 2.7e-09 37.1 0.2 0.0007 19.7 0.0 5.1 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.18 T125025_2 - 1.7e-05 24.6 14.2 0.25 11.1 0.2 6.1 4 1 3 7 7 7 3 Region in Clathrin and VPS Coatomer_WDAD PF04053.12 T125025_2 - 4.2e-05 22.6 18.6 0.096 11.6 0.2 5.4 4 2 3 7 7 7 3 Coatomer WD associated region PPR PF01535.18 T125025_2 - 0.0086 16.1 2.1 18 5.7 0.0 5.5 6 0 0 6 6 6 1 PPR repeat PPR_2 PF13041.4 T125025_2 - 0.02 15.0 0.2 0.89 9.7 0.0 3.9 4 0 0 4 4 4 0 PPR repeat family WD40 PF00400.30 T125025_2 - 0.047 14.4 0.4 0.68 10.8 0.0 3.3 3 0 0 3 3 3 0 WD domain, G-beta repeat SGL PF08450.10 T125025_2 - 0.14 11.6 0.0 0.76 9.2 0.0 2.3 2 0 0 2 2 2 0 SMP-30/Gluconolaconase/LRE-like region TPR_8 PF13181.4 T125025_2 - 8.3 6.8 8.1 74 3.8 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF1737 PF08410.8 T111060_1 - 0.027 14.2 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1737) Phage_holin_2_3 PF16080.3 T111060_1 - 0.28 10.8 3.1 0.61 9.8 3.1 1.5 1 0 0 1 1 1 0 Bacteriophage holin family HP1 PAF PF15715.3 T111060_1 - 0.58 10.7 5.4 1.4 9.5 2.2 2.4 2 0 0 2 2 2 0 PCNA-associated factor Pkinase PF00069.23 T111060_2 - 1.1e-74 251.0 0.0 1.5e-74 250.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T111060_2 - 1.1e-43 149.3 0.0 1.5e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 T111060_2 - 1.1e-20 73.0 0.2 2.9e-20 71.6 0.0 1.8 2 0 0 2 2 2 1 Kinase associated domain 1 Kinase-like PF14531.4 T111060_2 - 1.8e-06 27.4 0.0 2.8e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like UBA PF00627.29 T111060_2 - 2.5e-05 23.9 0.0 4.4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain RIO1 PF01163.20 T111060_2 - 0.00067 19.2 0.2 0.0012 18.3 0.2 1.3 1 0 0 1 1 1 1 RIO1 family UBA_2 PF08587.9 T111060_2 - 0.017 15.1 0.3 0.033 14.2 0.3 1.4 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) Kdo PF06293.12 T111060_2 - 0.023 13.9 0.1 0.04 13.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SMK-1 PF04802.13 T189710_2 - 8.6e-81 270.2 5.9 1.6e-80 269.3 5.9 1.5 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.21 T189710_2 - 0.00084 19.1 0.0 0.0018 18.1 0.0 1.5 1 0 0 1 1 1 1 WH1 domain Ran_BP1 PF00638.16 T189710_2 - 0.018 15.1 0.0 0.048 13.8 0.0 1.6 1 0 0 1 1 1 0 RanBP1 domain OxoDH_E1alpha_N PF12573.6 T163963_2 - 0.1 12.3 0.4 0.34 10.6 0.3 1.9 2 0 0 2 2 2 0 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal Guanylate_cyc PF00211.18 T024584_1 - 3.8e-13 49.3 0.1 6.6e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AAA_22 PF13401.4 T024584_1 - 0.0015 18.7 0.0 0.0048 17.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 T024584_1 - 0.0026 18.0 0.0 0.005 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.4 T024584_1 - 0.48 10.3 3.8 14 5.6 0.9 2.5 1 1 1 2 2 2 0 AAA domain Med16 PF11635.6 T165394_1 - 1.6e-126 423.0 0.0 2.1e-126 422.7 0.0 1.1 1 0 0 1 1 1 1 Mediator complex subunit 16 WD40 PF00400.30 T165394_1 - 0.0011 19.6 2.6 0.0022 18.7 0.8 2.6 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T165394_1 - 0.0022 18.1 0.1 0.078 13.2 0.1 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF2362 PF10154.7 T072072_2 - 4e-82 276.6 0.1 5.5e-82 276.2 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) DUF35_N PF12172.6 T072072_3 - 3.2 7.6 6.9 0.23 11.2 0.4 2.4 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) RINGv PF12906.5 T288473_1 - 1.1e-13 50.9 9.8 3.1e-13 49.5 9.8 1.9 1 0 0 1 1 1 1 RING-variant domain DUF836 PF05768.12 T288473_2 - 4.2e-09 36.6 0.0 9.2e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) PI-PLC-X PF00388.17 T001258_3 - 9.1e-64 213.3 0.1 1.7e-63 212.4 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 T001258_3 - 1.3e-39 135.0 0.7 2.2e-39 134.2 0.7 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.28 T001258_3 - 2.1e-15 56.7 0.0 4e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.9 T001258_3 - 3.1e-15 56.3 0.0 5.2e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_7 PF13499.4 T001258_3 - 4.9e-11 42.8 0.6 9.7e-11 41.9 0.2 1.7 2 0 0 2 2 2 1 EF-hand domain pair PH_12 PF16457.3 T001258_3 - 2.3e-08 34.5 0.0 5.1e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_1 PF00036.30 T001258_3 - 1.2e-07 30.6 0.8 0.00081 18.6 0.0 2.6 2 1 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T001258_3 - 4.5e-06 26.1 0.6 0.0093 15.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_10 PF14788.4 T001258_3 - 1.6e-05 24.5 0.1 3.2e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 EF hand PH PF00169.27 T001258_3 - 0.00065 20.0 0.0 0.0012 19.2 0.0 1.4 1 0 0 1 1 1 1 PH domain EF-hand_5 PF13202.4 T001258_3 - 0.0021 17.4 1.9 0.0026 17.1 0.1 2.0 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 T001258_3 - 0.01 15.4 2.9 0.072 12.7 0.1 2.9 2 1 1 3 3 3 0 EF-hand domain pair Mcp5_PH PF12814.5 T001258_3 - 0.083 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology EF-hand_4 PF12763.5 T001258_3 - 0.12 12.2 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand ABC_tran_Xtn PF12848.5 T001258_3 - 0.16 11.9 0.5 0.34 10.8 0.5 1.5 1 0 0 1 1 1 0 ABC transporter Syntaxin PF00804.23 T059354_2 - 1.7e-59 200.7 13.7 2.4e-59 200.2 13.7 1.2 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.17 T059354_2 - 1e-17 63.7 2.3 1e-17 63.7 2.3 2.5 3 0 0 3 3 3 1 SNARE domain Syntaxin_2 PF14523.4 T059354_2 - 1.4e-08 34.9 3.8 3e-08 33.8 3.8 1.6 1 0 0 1 1 1 1 Syntaxin-like protein Branch PF02485.19 T059354_2 - 0.03 13.7 0.2 0.048 13.0 0.2 1.2 1 0 0 1 1 1 0 Core-2/I-Branching enzyme SIMPL PF04402.12 T059354_2 - 0.15 12.4 1.1 0.26 11.6 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF541) PHD PF00628.27 T057922_1 - 1.5e-11 43.9 6.2 1.5e-11 43.9 6.2 3.0 3 0 0 3 3 3 1 PHD-finger C1_1 PF00130.20 T057922_1 - 0.024 14.4 9.1 0.021 14.6 2.0 4.2 4 0 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF1043 PF06295.10 T057922_1 - 0.043 13.7 0.3 0.07 13.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) PHD_2 PF13831.4 T057922_1 - 0.059 12.8 3.8 0.036 13.5 0.8 2.4 2 0 0 2 2 2 0 PHD-finger DUF1664 PF07889.10 T057922_1 - 0.09 12.6 4.1 0.14 12.0 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Zf_RING PF16744.3 T057922_1 - 0.12 12.4 3.7 0.5 10.4 3.7 2.1 1 0 0 1 1 1 0 KIAA1045 RING finger S6OS1 PF15676.3 T057922_1 - 0.21 9.9 3.5 0.33 9.2 3.5 1.1 1 0 0 1 1 1 0 Six6 opposite strand transcript 1 family OmpH PF03938.12 T057922_1 - 2.7 7.8 6.6 4 7.3 6.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Myc-LZ PF02344.13 T057922_1 - 6.3 6.8 9.7 13 5.8 9.7 1.5 1 0 0 1 1 1 0 Myc leucine zipper domain Adaptin_N PF01602.18 T178932_3 - 1.8e-148 495.3 3.1 2.1e-148 495.0 3.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.14 T178932_3 - 1.5e-44 150.7 0.0 3e-44 149.7 0.0 1.6 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.18 T178932_3 - 3.5e-20 72.2 0.1 6.6e-20 71.3 0.1 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.5 T178932_3 - 1.1e-07 31.9 0.8 1.2e-05 25.3 0.0 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 T178932_3 - 3.4e-06 27.2 1.8 0.011 15.9 0.2 4.4 3 1 0 4 4 4 1 HEAT repeats RIX1 PF08167.10 T178932_3 - 0.00035 20.2 1.8 0.012 15.2 0.1 3.3 2 1 0 3 3 3 1 rRNA processing/ribosome biogenesis HEAT PF02985.20 T178932_3 - 0.0085 16.1 3.9 44 4.6 0.0 4.7 4 0 0 4 4 4 0 HEAT repeat Dymeclin PF09742.7 T178932_3 - 0.08 11.3 1.3 0.12 10.6 1.3 1.2 1 0 0 1 1 1 0 Dyggve-Melchior-Clausen syndrome protein TIP120 PF08623.8 T178932_3 - 0.3 10.8 1.7 10 5.7 0.2 2.4 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) IFRD PF05004.11 T178932_3 - 0.68 8.9 3.7 0.58 9.1 1.1 2.1 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) IBN_N PF03810.17 T293132_3 - 2.5e-10 40.0 0.4 1.4e-09 37.6 0.1 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain CRM1_C PF08767.9 T293132_3 - 0.0063 15.6 1.5 0.016 14.3 1.5 1.6 1 0 0 1 1 1 1 CRM1 C terminal DnaJ PF00226.29 T120278_1 - 3e-26 91.2 2.1 4.8e-26 90.5 2.1 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.17 T120278_1 - 1.4e-14 54.1 17.4 2.8e-14 53.1 17.4 1.5 1 0 0 1 1 1 1 DnaJ central domain DnaJ_C PF01556.16 T120278_1 - 8.4e-06 25.8 0.1 1.2e-05 25.3 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain Anti-TRAP PF15777.3 T120278_1 - 0.036 13.9 9.8 0.55 10.1 2.2 2.5 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.17 T120278_1 - 0.81 9.6 6.8 5.7 6.9 0.3 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DnaJ_C PF01556.16 T120278_3 - 1.2e-27 96.7 0.4 1.8e-27 96.1 0.4 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain CHDCT2 PF08074.9 T072508_2 - 2.9e-87 291.1 0.4 7.8e-87 289.7 0.4 1.8 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain Methyltr_RsmB-F PF01189.15 T072508_2 - 8.3e-83 276.8 0.0 1.4e-82 276.1 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F DUF1086 PF06461.9 T072508_2 - 1.8e-60 202.7 0.0 3.9e-60 201.6 0.0 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.21 T072508_2 - 1.1e-58 198.5 0.0 2.1e-58 197.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF1087 PF06465.11 T072508_2 - 7.5e-26 89.9 6.0 7.5e-26 89.9 6.0 3.2 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1087) CHDNT PF08073.10 T072508_2 - 1.6e-25 88.6 0.1 4.5e-25 87.2 0.1 1.8 1 0 0 1 1 1 1 CHDNT (NUC034) domain Helicase_C PF00271.29 T072508_2 - 3.6e-22 78.7 0.0 6.9e-22 77.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 T072508_2 - 1.2e-20 73.0 27.9 4.9e-10 39.0 8.8 2.9 2 0 0 2 2 2 2 PHD-finger P120R PF08062.9 T072508_2 - 1.6e-19 69.0 31.8 2.3e-07 30.6 1.1 4.2 3 0 0 3 3 3 3 P120R (NUC006) repeat Chromo PF00385.22 T072508_2 - 1.1e-17 63.5 5.6 8.4e-12 44.7 0.9 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 T072508_2 - 1.3e-09 38.2 0.3 4.1e-09 36.5 0.0 2.1 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit Methyltr_RsmF_N PF17125.3 T072508_2 - 5.7e-09 36.2 0.0 1.9e-08 34.5 0.0 2.0 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Filament PF00038.19 T072508_2 - 4.7e-08 32.8 29.4 7.5e-08 32.2 9.2 3.3 3 0 0 3 3 2 2 Intermediate filament protein HDA2-3 PF11496.6 T072508_2 - 1.8e-06 27.2 0.0 4.1e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 FtsJ PF01728.17 T072508_2 - 0.013 15.5 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase PHD_2 PF13831.4 T072508_2 - 0.014 14.8 11.7 0.21 11.0 2.8 2.8 2 0 0 2 2 2 0 PHD-finger Methyltransf_25 PF13649.4 T072508_2 - 0.016 15.8 0.0 0.053 14.1 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain HMG_box PF00505.17 T072508_2 - 0.017 15.4 0.1 0.051 13.9 0.1 1.8 1 0 0 1 1 1 0 HMG (high mobility group) box PCMT PF01135.17 T072508_2 - 0.018 14.7 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.4 T072508_2 - 0.065 12.9 0.0 0.38 10.4 0.0 2.3 3 0 0 3 3 3 0 Methyltransferase domain Snapin_Pallidin PF14712.4 T072508_2 - 0.36 11.2 2.1 2.1 8.7 2.1 2.3 1 0 0 1 1 1 0 Snapin/Pallidin FTA4 PF13093.4 T072508_2 - 0.41 10.4 9.1 3.5 7.3 0.1 3.8 3 0 0 3 3 3 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 zf-PHD-like PF15446.4 T072508_2 - 0.8 9.2 10.7 2.2 7.7 1.0 3.0 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Filament PF00038.19 T072508_3 - 1.2e-08 34.8 5.7 1.7e-08 34.3 5.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein MBT PF02820.16 T008955_3 - 1e-47 160.2 0.0 9.3e-25 86.6 0.0 2.5 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 T008955_3 - 1.6e-35 121.8 0.1 2.9e-35 121.0 0.1 1.5 1 0 0 1 1 1 1 SLED domain AlbA_2 PF04326.12 T008955_3 - 5.4e-27 94.4 0.0 9.7e-27 93.6 0.0 1.3 1 0 0 1 1 1 1 Putative DNA-binding domain SAM_1 PF00536.28 T008955_3 - 5.7e-16 58.6 0.1 9.5e-16 57.9 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.1 T008955_3 - 2.5e-12 47.2 17.6 7.2e-12 45.7 17.6 1.9 1 0 0 1 1 1 1 RNA binding Region SAM_2 PF07647.15 T008955_3 - 7.8e-07 29.0 0.0 1.5e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 T008955_3 - 0.0054 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Lectin_C PF00059.19 T357779_1 - 2.4e-13 50.6 7.7 4.1e-13 49.9 7.7 1.4 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 T357779_1 - 0.00078 19.0 1.2 0.0015 18.0 1.2 1.4 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like DMPK_coil PF08826.8 T357779_1 - 0.0069 16.4 12.4 0.0069 16.4 12.4 1.8 2 0 0 2 2 2 1 DMPK coiled coil domain like Exonuc_VII_L PF02601.13 T357779_1 - 0.21 11.0 8.2 0.29 10.5 8.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3450 PF11932.6 T357779_1 - 0.3 10.2 11.7 0.51 9.5 11.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Occludin_ELL PF07303.11 T357779_1 - 1.9 9.1 8.0 21 5.7 4.4 2.3 2 0 0 2 2 2 0 Occludin homology domain IncA PF04156.12 T357779_1 - 2 8.1 21.7 5.2 6.7 21.8 1.6 1 1 1 2 2 2 0 IncA protein HOOK PF05622.10 T357779_1 - 2.5 6.0 16.4 3.4 5.6 16.4 1.1 1 0 0 1 1 1 0 HOOK protein Cystatin PF00031.19 T256474_2 - 3.8e-20 71.8 0.1 8.4e-19 67.5 0.0 2.3 2 0 0 2 2 2 1 Cystatin domain Lectin_leg-like PF03388.11 T194621_3 - 2.5e-79 265.8 0.0 3e-64 216.4 0.0 2.1 2 0 0 2 2 2 2 Legume-like lectin family PMP1_2 PF08114.9 T194621_3 - 0.054 13.1 0.3 0.13 11.9 0.3 1.7 1 0 0 1 1 1 0 ATPase proteolipid family LRR_8 PF13855.4 T329715_1 - 4.2e-22 77.5 12.6 2e-09 36.9 1.2 3.9 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 T329715_1 - 1.5e-12 47.3 17.6 4.5e-05 23.6 2.6 4.6 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 T329715_1 - 0.32 11.0 10.4 20 5.4 0.4 5.1 5 0 0 5 5 5 0 Leucine Rich repeat SAP25 PF15476.4 T329715_2 - 9.2e-103 342.1 16.8 9.2e-103 342.1 16.8 2.1 2 0 0 2 2 2 1 Histone deacetylase complex subunit SAP25 CH PF00307.29 T329715_2 - 2.2e-13 50.2 0.0 3.6e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 T329715_2 - 0.0055 16.4 0.0 0.009 15.7 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain Vault PF01505.16 T129961_1 - 2.4e-22 78.8 0.1 1.3e-15 57.3 0.0 2.8 2 0 0 2 2 2 2 Major Vault Protein repeat MVP_shoulder PF11978.6 T129961_3 - 2.1e-52 176.0 0.0 4.3e-52 175.0 0.0 1.6 1 0 0 1 1 1 1 Shoulder domain Vault PF01505.16 T129961_3 - 2e-30 104.7 2.2 1e-12 47.9 0.0 4.0 3 0 0 3 3 3 3 Major Vault Protein repeat Band_7 PF01145.23 T129961_3 - 8.5e-05 22.5 0.6 0.00029 20.8 0.6 2.0 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF2543 PF10820.6 T129961_3 - 0.2 11.7 0.4 0.38 10.8 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2543) PRY PF13765.4 T300023_1 - 7.9e-22 76.5 0.4 4.2e-21 74.2 0.3 2.3 3 0 0 3 3 3 1 SPRY-associated domain SPRY PF00622.26 T300023_1 - 1.2e-20 73.7 0.1 2.1e-20 72.9 0.1 1.3 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 T300023_1 - 3.4e-11 43.0 0.5 3.4e-11 43.0 0.5 3.2 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_4 PF15227.4 T300023_1 - 2.2e-10 40.4 15.0 1e-09 38.2 15.0 2.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 T300023_1 - 1.8e-06 27.7 11.2 3.8e-06 26.7 8.3 3.0 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 T300023_1 - 4.7e-05 23.0 12.4 4.7e-05 23.0 12.4 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Kelch_1 PF01344.23 T028832_2 - 4.7e-49 163.6 0.3 9.2e-11 41.0 0.1 7.6 7 0 0 7 7 7 7 Kelch motif Kelch_6 PF13964.4 T028832_2 - 1.7e-38 129.5 1.9 8.9e-08 32.0 0.0 8.3 3 3 5 8 8 8 7 Kelch motif Kelch_4 PF13418.4 T028832_2 - 3.7e-24 84.3 0.3 0.00031 20.5 0.0 7.4 7 1 1 8 8 8 4 Galactose oxidase, central domain Kelch_2 PF07646.13 T028832_2 - 1.3e-19 69.1 0.0 0.0087 15.9 0.0 7.1 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.4 T028832_2 - 2.8e-19 68.8 0.3 0.00011 22.3 0.0 7.7 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.4 T028832_2 - 3.1e-09 36.5 2.0 0.01 15.6 0.0 6.7 7 0 0 7 7 7 2 Kelch motif IP_trans PF02121.16 T088300_2 - 1.4e-112 375.1 1.4 2e-112 374.6 1.4 1.2 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein DDHD PF02862.15 T088300_2 - 1.6e-51 175.6 0.0 5.2e-51 174.0 0.0 1.8 2 0 0 2 2 2 1 DDHD domain PH PF00169.27 T055464_2 - 4.7e-19 68.7 0.3 1.2e-18 67.4 0.0 1.9 2 0 0 2 2 2 1 PH domain WW PF00397.24 T055464_2 - 5.9e-10 38.8 3.5 3.4e-05 23.6 0.1 3.1 3 0 0 3 3 3 2 WW domain PH_11 PF15413.4 T055464_2 - 4.2e-09 36.7 0.1 1e-08 35.4 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 T055464_2 - 1.4e-05 25.1 0.0 0.036 14.2 0.0 2.5 1 1 1 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.4 T055464_2 - 0.066 13.5 0.0 0.066 13.5 0.0 2.2 3 0 0 3 3 3 0 Pleckstrin homology domain OGG_N PF07934.10 T055464_2 - 0.21 11.6 2.2 0.6 10.1 2.2 1.7 1 0 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain FRB_dom PF08771.9 T055464_2 - 0.74 10.1 4.2 2 8.8 4.2 1.7 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain APG6 PF04111.10 T055464_2 - 0.93 8.7 13.1 2.2 7.5 13.1 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1640 PF07798.9 T055464_2 - 1.1 9.1 9.7 1.8 8.5 8.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) DUF342 PF03961.11 T055464_2 - 1.8 7.0 6.5 2.8 6.3 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) V-set PF07686.15 T206119_1 - 2.3e-06 27.6 0.0 3.7e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain V-set_2 PF15910.3 T206119_1 - 0.0021 18.0 0.0 0.0038 17.2 0.0 1.4 1 0 0 1 1 1 1 ICOS V-set domain GHMP_kinases_N PF00288.24 T086165_1 - 6.5e-07 29.4 0.0 1.5e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.11 T086165_1 - 0.00023 21.4 0.1 0.00051 20.2 0.1 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.7 T086165_2 - 0.075 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Galactokinase galactose-binding signature NAP PF00956.16 T310156_2 - 1e-24 87.1 0.2 9.1e-22 77.4 0.0 2.7 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Lipoprotein_7 PF01540.14 T310156_2 - 0.06 12.5 1.5 0.092 11.9 1.5 1.2 1 0 0 1 1 1 0 Adhesin lipoprotein EF-hand_2 PF09068.9 T160721_1 - 1.5e-35 121.9 0.8 2.8e-35 121.0 0.8 1.5 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.9 T160721_1 - 4.6e-30 103.7 0.0 2.4e-29 101.5 0.0 2.3 2 0 0 2 2 2 1 EF-hand ZZ PF00569.15 T160721_1 - 8.5e-10 38.2 9.0 2.8e-09 36.5 9.0 1.9 1 0 0 1 1 1 1 Zinc finger, ZZ type CRISPR_Cse2 PF09485.8 T160721_1 - 0.00035 21.0 1.9 0.0039 17.6 2.3 2.3 2 0 0 2 2 2 1 CRISPR-associated protein Cse2 (CRISPR_cse2) SOGA PF11365.6 T160721_1 - 0.075 14.0 7.2 0.18 12.8 7.2 1.7 1 0 0 1 1 1 0 Protein SOGA Seryl_tRNA_N PF02403.20 T160721_1 - 0.24 11.5 9.2 0.52 10.4 9.2 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Mnd1 PF03962.13 T160721_1 - 0.43 10.3 11.0 0.94 9.2 11.0 1.5 1 0 0 1 1 1 0 Mnd1 family APG6 PF04111.10 T160721_1 - 0.8 8.9 10.4 1.5 8.0 10.4 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 ZapB PF06005.10 T160721_1 - 1.2 9.5 16.9 3.2 8.1 16.3 2.1 1 1 0 1 1 1 0 Cell division protein ZapB MerR-DNA-bind PF09278.9 T160721_1 - 1.5 9.3 10.4 2.9 8.4 9.7 2.0 1 1 0 1 1 1 0 MerR, DNA binding YlqD PF11068.6 T160721_1 - 1.6 9.0 14.8 3.5 7.9 14.8 1.5 1 0 0 1 1 1 0 YlqD protein DUF342 PF03961.11 T160721_1 - 3.1 6.2 6.1 4.6 5.6 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Exonuc_VII_L PF02601.13 T160721_1 - 5.9 6.2 6.6 11 5.3 6.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit LRR_6 PF13516.4 T134784_1 - 6.9e-13 47.4 18.8 5.1e-05 22.9 0.1 8.6 9 0 0 9 9 9 3 Leucine Rich repeat LRR_1 PF00560.31 T134784_1 - 0.0017 18.4 2.7 12 6.7 0.0 6.8 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_4 PF12799.5 T134784_1 - 0.3 11.4 10.7 36 4.8 0.0 5.8 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) CARMIL_C PF16000.3 T134784_3 - 9e-67 225.7 1.0 1.2e-66 225.3 0.1 1.8 2 0 0 2 2 2 1 CARMIL C-terminus Amelin PF05111.10 T266165_2 - 6.8e-202 671.0 38.5 2e-120 402.6 13.5 2.8 1 1 1 2 2 2 2 Ameloblastin precursor (Amelin) C2 PF00168.28 T119461_2 - 6e-07 29.6 0.1 2.3e-05 24.5 0.1 2.3 2 0 0 2 2 2 1 C2 domain LRR_4 PF12799.5 T283884_2 - 0.0012 19.1 9.8 0.071 13.4 0.1 5.2 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) NACHT PF05729.10 T283884_3 - 5e-38 130.5 0.1 9e-38 129.7 0.1 1.5 1 0 0 1 1 1 1 NACHT domain BIR PF00653.19 T283884_3 - 2.5e-19 69.6 0.2 5.9e-19 68.4 0.2 1.7 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain NB-ARC PF00931.20 T283884_3 - 3.9e-05 22.7 0.0 6.3e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_30 PF13604.4 T283884_3 - 0.028 14.0 0.0 0.047 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.4 T283884_3 - 0.06 13.5 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.7 T283884_3 - 0.18 10.9 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) zf-H2C2_2 PF13465.4 T174665_1 - 1.2e-32 110.7 48.8 3.9e-06 26.9 1.0 9.1 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 T174665_1 - 2.7e-26 90.4 55.7 9.7e-05 22.5 1.4 8.6 7 0 0 7 7 7 6 Zinc finger, C2H2 type KRAB PF01352.25 T174665_1 - 1.2e-22 79.1 0.0 2.3e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T174665_1 - 0.37 11.6 86.5 0.0082 16.8 4.3 10.2 10 0 0 10 10 10 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T374230_3 - 2.9e-83 270.7 88.4 2e-07 31.0 0.1 14.4 14 1 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 T374230_3 - 6.8e-66 215.1 91.8 2.1e-06 27.7 0.2 13.9 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T374230_3 - 3.7e-27 92.5 94.6 0.0017 18.8 0.4 14.0 14 0 0 14 14 14 11 C2H2-type zinc finger KRAB PF01352.25 T374230_3 - 1.2e-25 88.8 0.2 2.1e-25 88.0 0.2 1.4 1 0 0 1 1 1 1 KRAB box C1_4 PF07975.10 T374230_3 - 1.8e-07 31.2 52.0 0.028 14.5 7.1 8.6 5 2 3 8 8 8 5 TFIIH C1-like domain zf-C2H2_6 PF13912.4 T374230_3 - 6.3e-07 29.1 64.3 0.00097 18.9 0.1 11.9 12 0 0 12 12 12 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T374230_3 - 0.016 15.2 67.1 0.039 13.9 1.8 9.3 3 2 9 12 12 12 0 Zinc ribbon domain DUF3268 PF11672.6 T374230_3 - 0.31 11.2 38.2 0.45 10.7 0.2 6.8 4 1 2 8 8 8 0 zinc-finger-containing domain DUF4934 PF16288.3 T374230_3 - 3.1 7.6 9.8 9.1 6.1 0.1 5.1 4 2 3 7 7 7 0 Domain of unknown function (DUF4934) zf-C2H2_jaz PF12171.6 T374230_3 - 9.4 6.6 41.1 0.75 10.1 0.0 10.6 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding Lep_receptor_Ig PF06328.9 T012597_2 - 3.5e-23 81.3 0.7 1.5e-22 79.3 0.7 2.2 1 0 0 1 1 1 1 Ig-like C2-type domain fn3 PF00041.19 T012597_2 - 4.2e-07 30.1 2.9 0.0015 18.7 0.0 3.3 4 0 0 4 4 4 2 Fibronectin type III domain RP-C_C PF11800.6 T378546_1 - 0.026 14.5 5.7 0.069 13.1 5.7 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region SKA1 PF07160.10 T378546_1 - 0.045 13.5 9.5 0.098 12.3 9.5 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF4834 PF16118.3 T378546_1 - 0.051 14.4 3.4 0.15 12.9 3.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Peroxin-13_N PF04088.11 T378546_1 - 0.44 10.7 3.9 0.89 9.7 3.9 1.4 1 0 0 1 1 1 0 Peroxin 13, N-terminal region EPL1 PF10513.7 T378546_1 - 0.93 9.7 6.7 2.8 8.2 6.7 1.7 1 0 0 1 1 1 0 Enhancer of polycomb-like Anoctamin PF04547.10 T378546_1 - 1 7.9 2.9 1.7 7.2 2.9 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel ZYG-11_interact PF05884.10 T378546_1 - 1.1 8.5 7.4 1.7 7.8 7.4 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 V_ATPase_I PF01496.17 T378546_1 - 1.4 6.6 6.5 2.1 6.0 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rpp20 PF12328.6 T378546_1 - 1.7 8.5 8.6 3.3 7.5 8.6 1.4 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P eIF-3_zeta PF05091.10 T378546_1 - 2.2 7.0 7.9 3.6 6.3 7.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CagX PF03524.13 T378546_1 - 3 7.3 6.1 5.3 6.5 6.1 1.2 1 0 0 1 1 1 0 Conjugal transfer protein ALMT PF11744.6 T378546_1 - 3.1 6.4 6.6 5 5.7 6.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Roughex PF06020.9 T378546_1 - 3.7 6.4 9.8 7 5.5 9.8 1.4 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.6 T378546_1 - 5 6.5 32.6 0.036 13.5 23.9 1.8 2 0 0 2 2 1 0 Spt20 family Presenilin PF01080.15 T378546_1 - 5.2 5.6 7.5 14 4.2 7.5 1.6 1 0 0 1 1 1 0 Presenilin Coilin_N PF15862.3 T378546_1 - 7.1 6.3 8.8 17 5.1 8.8 1.6 1 0 0 1 1 1 0 Coilin N-terminus TERB2 PF15101.4 T378546_1 - 7.4 6.5 10.3 15 5.4 10.3 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FERM_M PF00373.16 T378546_2 - 7e-17 61.8 0.0 1.3e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 FERM central domain PDZ PF00595.22 T378546_3 - 1.8e-07 31.2 0.0 3.2e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T378546_3 - 0.00063 19.9 0.0 0.0011 19.1 0.0 1.2 1 0 0 1 1 1 1 PDZ domain GDNF PF02351.14 T361614_3 - 1.6e-06 28.9 30.9 0.00056 20.7 10.5 3.5 3 0 0 3 3 3 2 GDNF/GAS1 domain DUF3668 PF12416.6 T288181_3 - 2.3e-95 318.6 0.3 7.3e-95 316.9 0.0 2.1 2 0 0 2 2 2 1 Cep120 protein C2 PF00168.28 T288181_3 - 1.5e-08 34.7 0.0 0.00082 19.5 0.0 3.5 3 0 0 3 3 3 2 C2 domain DUF4497 PF14924.4 T288181_3 - 0.098 13.0 0.0 8.7 6.7 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) Fascin PF06268.11 T332630_1 - 3e-57 191.5 0.1 5.1e-28 97.4 0.0 3.5 3 0 0 3 3 3 3 Fascin domain FRG1 PF06229.10 T332630_1 - 1.6e-05 24.6 0.0 0.76 9.3 0.0 3.5 2 2 1 3 3 3 2 FRG1-like domain DUF569 PF04601.11 T332630_1 - 0.038 13.6 0.0 0.73 9.4 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF569) FGF PF00167.16 T332630_1 - 0.1 12.6 0.0 0.37 10.8 0.0 1.8 2 0 0 2 2 2 0 Fibroblast growth factor Arf PF00025.19 T332630_2 - 2.6e-74 248.3 0.1 3.6e-74 247.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 T332630_2 - 1.1e-12 48.1 0.1 1.6e-12 47.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 T332630_2 - 2.5e-12 46.5 0.0 3.5e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 T332630_2 - 7.3e-11 41.8 0.0 1.1e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 T332630_2 - 7.7e-10 38.3 1.0 2.8e-07 29.9 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 T332630_2 - 2.3e-09 36.8 0.0 3.1e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 T332630_2 - 0.0025 17.8 0.0 0.0038 17.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 T332630_2 - 0.26 10.4 0.1 0.41 9.8 0.1 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase zf-C2H2 PF00096.24 T220205_1 - 2.6e-21 74.7 56.2 0.00016 21.8 1.1 9.5 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T220205_1 - 1.7e-15 56.2 55.2 0.0097 16.5 0.6 9.4 8 0 0 8 8 8 7 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T220205_1 - 2.2e-07 30.8 0.3 2.2e-07 30.8 0.3 12.4 12 0 0 12 12 12 3 Zinc-finger double domain zf-H2C2_5 PF13909.4 T220205_1 - 5.3e-05 22.7 2.6 5.3e-05 22.7 2.6 7.4 9 0 0 9 9 8 1 C2H2-type zinc-finger domain PHF5 PF03660.12 T220205_1 - 0.067 13.3 5.4 5.6 7.1 0.4 3.2 2 1 0 2 2 2 0 PHF5-like protein C1_1 PF00130.20 T220205_1 - 0.5 10.1 15.4 0.44 10.3 1.4 4.5 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_2 PF12756.5 T220205_1 - 1.9 8.7 35.6 0.01 16.0 3.5 6.4 4 2 1 6 6 6 0 C2H2 type zinc-finger (2 copies) DUF3268 PF11672.6 T220205_1 - 2.2 8.5 7.5 14 6.0 0.2 2.6 2 0 0 2 2 2 0 zinc-finger-containing domain CpXC PF14353.4 T220205_1 - 3.2 7.7 16.6 1.8 8.5 0.4 5.0 4 1 0 4 4 4 0 CpXC protein Actin_micro PF17003.3 T220205_1 - 4.1 6.4 13.6 2.4 7.1 0.1 4.0 2 1 0 3 3 3 0 Putative actin-like family AKAP95 PF04988.10 T220205_1 - 5.7 7.0 13.8 9.7 6.3 1.1 3.7 3 0 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) Filament PF00038.19 T078969_1 - 2.6e-91 306.3 35.1 3.1e-91 306.1 35.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 T078969_1 - 0.00095 19.1 28.2 0.0033 17.4 3.5 3.4 1 1 3 4 4 4 2 TPR/MLP1/MLP2-like protein Alanine_zipper PF11839.6 T078969_1 - 0.0012 19.0 3.0 0.0012 19.0 3.0 2.0 2 0 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein Spc7 PF08317.9 T078969_1 - 0.0017 17.2 31.4 0.022 13.5 8.4 2.9 1 1 2 3 3 3 3 Spc7 kinetochore protein Reo_sigmaC PF04582.10 T078969_1 - 0.0038 16.5 6.1 0.15 11.3 0.7 2.3 1 1 0 2 2 2 2 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.7 T078969_1 - 0.0055 16.6 8.1 0.0055 16.6 8.1 3.9 1 1 3 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF5082 PF16888.3 T078969_1 - 0.0061 16.8 19.6 0.1 12.8 3.6 3.7 1 1 3 4 4 4 2 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.10 T078969_1 - 0.0089 15.9 14.9 0.071 13.0 3.5 4.0 1 1 3 4 4 4 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1732 PF08340.9 T078969_1 - 0.029 14.2 5.4 1.2 9.0 0.3 3.0 3 0 0 3 3 2 0 Domain of unknown function (DUF1732) AAA_13 PF13166.4 T078969_1 - 0.03 12.9 19.4 0.055 12.0 19.3 1.5 1 1 0 1 1 1 0 AAA domain DUF1664 PF07889.10 T078969_1 - 0.042 13.7 17.3 0.19 11.6 2.4 4.0 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.7 T078969_1 - 0.17 11.9 23.9 0.12 12.4 5.1 2.8 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Fib_alpha PF08702.8 T078969_1 - 0.22 11.6 21.9 0.53 10.3 7.2 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF883 PF05957.11 T078969_1 - 0.24 11.9 12.3 0.49 10.9 4.8 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Golgin_A5 PF09787.7 T078969_1 - 0.28 10.5 25.5 1.6 8.0 11.4 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 TMPIT PF07851.11 T078969_1 - 0.42 9.7 13.6 0.14 11.2 3.5 2.1 1 1 1 2 2 2 0 TMPIT-like protein DUF4337 PF14235.4 T078969_1 - 0.56 10.2 11.1 0.073 13.0 3.8 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4337) ATG16 PF08614.9 T078969_1 - 1.1 9.3 27.5 0.52 10.3 13.5 3.5 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) JIP_LZII PF16471.3 T078969_1 - 1.1 9.3 19.1 15 5.7 0.9 4.9 3 1 1 4 4 4 0 JNK-interacting protein leucine zipper II ADIP PF11559.6 T078969_1 - 1.3 8.9 24.0 0.08 12.9 8.2 3.2 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding TraC PF07820.10 T078969_1 - 2.4 8.4 7.7 1.8 8.8 4.8 2.3 2 0 0 2 2 2 0 TraC-like protein NPV_P10 PF05531.10 T078969_1 - 2.7 8.4 11.8 0.65 10.4 0.7 3.7 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.9 T078969_1 - 3.3 7.9 5.0 2.8 8.1 1.5 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF745 PF05335.11 T078969_1 - 4.7 6.8 17.8 1.1 8.9 9.9 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF745) IncA PF04156.12 T078969_1 - 5.3 6.6 32.1 0.13 11.9 13.1 3.2 1 1 2 3 3 3 0 IncA protein DUF4164 PF13747.4 T078969_1 - 5.8 7.1 21.1 1 9.6 1.1 3.7 2 2 1 3 3 3 0 Domain of unknown function (DUF4164) Rootletin PF15035.4 T078969_1 - 5.8 6.8 22.8 5.5 6.9 6.6 2.9 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion THOC7 PF05615.11 T078969_1 - 6.3 7.0 23.9 17 5.6 1.7 4.0 1 1 2 3 3 3 0 Tho complex subunit 7 FlaC_arch PF05377.9 T078969_1 - 7.5 6.9 17.2 5.8 7.3 0.8 5.4 4 2 1 5 5 5 0 Flagella accessory protein C (FlaC) COG2 PF06148.9 T078969_1 - 7.9 6.4 16.3 17 5.4 2.0 4.0 2 2 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 BicD PF09730.7 T078969_1 - 9.3 4.4 30.5 0.4 8.9 10.8 2.9 1 1 1 3 3 3 0 Microtubule-associated protein Bicaudal-D Glyco_tran_28_C PF04101.14 T378878_2 - 9.7e-18 64.6 0.0 1.8e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain OTU PF02338.17 T378878_2 - 1.2e-11 45.1 0.0 2.3e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease MOSC PF03473.15 T030853_2 - 2.7e-57 192.3 0.0 1.9e-34 118.3 0.0 3.2 3 0 0 3 3 3 3 MOSC domain MOSC_N PF03476.14 T030853_2 - 2.5e-56 188.6 0.0 1.6e-34 118.2 0.0 2.3 2 0 0 2 2 2 2 MOSC N-terminal beta barrel domain DUF4175 PF13779.4 T030853_2 - 0.072 10.9 1.6 0.1 10.4 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) WD40 PF00400.30 T353938_1 - 2.5e-11 43.8 8.8 0.0007 20.2 0.0 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T353938_1 - 5.5e-06 26.5 0.6 3.5 7.9 0.0 3.9 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Maf1 PF09174.8 T353938_2 - 6.9e-62 208.1 0.0 9.3e-62 207.7 0.0 1.2 1 0 0 1 1 1 1 Maf1 regulator DUF4712 PF15830.3 T242474_1 - 3.6e-141 469.0 3.1 5.1e-141 468.6 3.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4712) UCH PF00443.27 T242474_1 - 4e-82 275.4 0.1 5.6e-82 275.0 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.4 T242474_1 - 8.9e-31 105.5 0.1 1.7e-30 104.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.10 T242474_1 - 1.3e-22 80.1 1.0 3.2e-22 78.8 1.0 1.7 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.4 T242474_1 - 1.5e-19 70.6 0.0 3.1e-12 46.6 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.4 T242474_1 - 8.9e-05 22.2 0.0 0.00066 19.3 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.6 T242474_1 - 0.001 18.4 0.0 0.0022 17.3 0.0 1.4 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 CW_binding_1 PF01473.18 T242474_1 - 0.89 9.9 4.3 3.1 8.2 4.3 2.0 1 0 0 1 1 1 0 Putative cell wall binding repeat ig PF00047.23 T181001_3 - 8.5e-35 118.7 0.0 2.4e-13 49.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T181001_3 - 6.1e-16 58.4 0.0 1.5e-07 31.5 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 T181001_3 - 1.6e-14 54.2 0.0 0.00015 22.2 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T181001_3 - 1.1e-06 28.6 0.0 5.5 7.1 0.0 5.0 5 1 1 6 6 6 3 Immunoglobulin V-set domain SIT PF15330.4 T181001_3 - 0.027 14.7 0.0 0.065 13.5 0.0 1.6 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT C2-set_2 PF08205.10 T177011_1 - 2.2e-20 72.4 0.2 2.2e-20 72.4 0.2 2.3 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 T177011_1 - 2.2e-12 47.3 2.4 0.002 18.6 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T177011_1 - 3.4e-11 43.0 0.0 0.0049 16.9 0.0 3.9 3 2 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T177011_1 - 3.7e-10 39.8 0.0 4.5e-09 36.3 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T177011_1 - 7.7e-05 22.8 0.6 1 9.6 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 T177011_1 - 0.00014 21.7 0.0 0.58 10.1 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.15 T177011_2 - 6.2e-07 29.4 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain DSPc PF00782.18 T144950_2 - 8e-33 112.9 0.0 1.4e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.9 T144950_2 - 4.4e-10 39.2 5.1 8.1e-10 38.4 5.1 1.5 1 0 0 1 1 1 1 DEK C terminal domain DUF1899 PF08953.9 T144950_3 - 1.4e-29 101.7 0.0 2.5e-29 100.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 T144950_3 - 8.7e-21 73.4 0.2 1.8e-20 72.4 0.2 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 T144950_3 - 7.1e-13 48.7 5.4 0.0012 19.5 0.2 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T144950_3 - 2e-07 31.1 0.1 0.0018 18.4 0.0 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Mei5 PF10376.7 T048102_3 - 1.3e-84 283.1 20.0 1.7e-84 282.7 20.0 1.1 1 0 0 1 1 1 1 Double-strand recombination repair protein Mei5_like PF17021.3 T048102_3 - 0.16 11.9 4.1 0.14 12.1 2.6 1.7 1 1 1 2 2 2 0 Putative double-strand recombination repair-like MAPEG PF01124.16 T271963_1 - 2.8e-18 65.9 3.8 4.3e-18 65.3 3.8 1.2 1 0 0 1 1 1 1 MAPEG family CATSPERD PF15020.4 T034371_2 - 1.9e-25 89.2 1.2 2.7e-25 88.6 1.2 1.1 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit delta RhoGAP PF00620.25 T041677_2 - 4.4e-16 58.9 0.0 8.6e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain ATG16 PF08614.9 T041677_2 - 0.00071 19.7 7.2 0.0013 18.9 7.2 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.5 T041677_2 - 0.0023 17.9 7.4 0.0039 17.2 7.4 1.2 1 0 0 1 1 1 1 Tropomyosin like IncA PF04156.12 T041677_2 - 0.014 15.1 2.1 0.025 14.2 2.1 1.4 1 0 0 1 1 1 0 IncA protein HAUS-augmin3 PF14932.4 T041677_2 - 0.13 11.6 4.9 0.22 10.9 4.9 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 ADIP PF11559.6 T041677_2 - 0.2 11.6 6.7 0.32 10.9 6.7 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding CALCOCO1 PF07888.9 T041677_2 - 0.32 9.4 7.3 0.47 8.8 7.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like APG6 PF04111.10 T041677_2 - 0.39 9.9 4.6 0.65 9.2 4.6 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 TPR_MLP1_2 PF07926.10 T041677_2 - 2.2 8.2 10.8 4.1 7.3 10.8 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein CENP-Q PF13094.4 T041677_2 - 7.8 6.5 10.0 14 5.7 10.0 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit PH PF00169.27 T041677_3 - 4.3e-22 78.5 0.0 7.9e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 PH domain RhoGAP PF00620.25 T041677_3 - 1.3e-20 73.7 0.0 1.9e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain PH_11 PF15413.4 T041677_3 - 8.8e-06 26.0 0.2 0.0003 21.0 0.2 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.4 T041677_3 - 0.003 17.7 0.1 0.17 12.1 0.1 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.4 T041677_3 - 0.029 14.4 0.1 0.066 13.2 0.0 1.5 2 0 0 2 2 2 0 PH domain DNA_pol3_delta2 PF13177.4 T092722_1 - 2.1e-11 43.8 0.3 3.6e-11 43.0 0.3 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.27 T092722_1 - 1.2e-06 28.9 0.0 2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.13 T092722_1 - 1.2e-05 24.3 0.1 1.8e-05 23.8 0.1 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein DNA_pol3_delta PF06144.11 T092722_1 - 0.0063 16.2 0.1 0.011 15.5 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_16 PF13191.4 T092722_1 - 0.047 13.9 0.0 0.11 12.8 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 T092722_1 - 0.068 13.3 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.25 T092722_1 - 0.078 13.4 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 ABC transporter FAM153 PF15722.3 T294464_2 - 3.1e-105 346.5 23.0 1.3e-39 135.0 7.4 4.4 2 1 2 4 4 4 4 FAM153 family MFS_1 PF07690.14 T154230_1 - 1e-24 87.0 25.8 3.2e-13 49.2 14.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.12 T154230_1 - 0.00084 18.6 6.7 0.0013 18.0 6.7 1.2 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB ATG22 PF11700.6 T154230_1 - 0.19 10.1 3.1 0.33 9.4 3.1 1.3 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Sugar_tr PF00083.22 T154230_2 - 0.17 10.6 3.8 0.26 10.0 3.8 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter Arm PF00514.21 T154230_3 - 0.00032 20.5 0.0 0.00032 20.5 0.0 1.8 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat Myosin_head PF00063.19 T154462_1 - 8.3e-63 212.5 0.0 1.2e-62 212.1 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.4 T154462_1 - 0.019 15.2 0.0 0.042 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 T154462_1 - 0.025 14.7 0.0 0.044 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain SH3_2 PF07653.15 T154462_2 - 7.7e-10 38.2 0.0 1.6e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T154462_2 - 1.9e-07 30.7 0.0 2.3e-06 27.2 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain Myosin_head PF00063.19 T154462_3 - 1.2e-49 169.0 0.0 2.5e-49 168.0 0.0 1.4 2 0 0 2 2 2 1 Myosin head (motor domain) MyTH4 PF00784.15 T154462_3 - 1.5e-46 157.1 6.6 1.3e-25 89.9 0.0 3.3 4 0 0 4 4 4 2 MyTH4 domain FERM_M PF00373.16 T154462_3 - 9.4e-15 54.9 0.2 9.4e-15 54.9 0.2 1.9 2 0 0 2 2 2 1 FERM central domain IQ PF00612.25 T154462_3 - 0.63 9.9 3.7 3.3 7.6 3.7 2.3 1 0 0 1 1 1 0 IQ calmodulin-binding motif Pkinase_Tyr PF07714.15 T334739_2 - 5e-65 219.2 0.0 7.9e-65 218.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 T334739_2 - 1.3e-56 191.3 0.0 3e-56 190.1 0.0 1.6 1 1 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 T334739_2 - 1e-27 97.0 0.0 1.5e-27 96.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 T334739_2 - 1.2e-24 86.3 0.0 1.3e-14 54.2 0.7 2.5 2 0 0 2 2 2 2 Fibronectin type III domain SAM_2 PF07647.15 T334739_2 - 2.2e-16 59.6 0.0 3.8e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.4 T334739_2 - 7.6e-16 58.6 0.0 1.7e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.28 T334739_2 - 1.3e-11 44.6 0.0 2.3e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.11 T334739_2 - 1e-06 28.3 3.8 1e-06 28.3 3.8 4.0 5 0 0 5 5 5 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.3 T334739_2 - 0.00011 22.6 0.5 0.00024 21.5 0.5 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PDZ_2 PF13180.4 T087969_2 - 7.3e-08 32.5 0.0 1.3e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.22 T087969_2 - 0.00066 19.9 0.1 0.0011 19.1 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) WD40 PF00400.30 T087969_3 - 1.2e-14 54.3 4.3 4.5e-05 24.0 0.3 7.3 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T087969_3 - 0.0031 17.7 0.0 0.025 14.7 0.0 2.5 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Yae1_N PF09811.7 T337551_1 - 0.049 13.2 3.6 0.099 12.2 3.6 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal DUF3704 PF12488.6 T337551_1 - 1.4 8.5 4.3 0.71 9.4 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3704) FG-GAP PF01839.21 T337551_2 - 7.6 6.6 5.6 3.3e+02 1.4 0.1 4.4 4 0 0 4 4 4 0 FG-GAP repeat PKD PF00801.18 T125311_1 - 7e-217 701.7 96.8 9.9e-24 82.8 1.0 16.7 16 0 0 16 16 16 15 PKD domain REJ PF02010.13 T125311_1 - 5.3e-109 364.9 0.0 3e-88 296.5 0.0 3.2 3 0 0 3 3 3 2 REJ domain PKD_3 PF16820.3 T125311_1 - 3e-07 29.9 0.0 6.8 6.4 0.0 6.5 7 0 0 7 7 7 3 PKD-like domain Y_Y_Y PF07495.11 T125311_1 - 2.5e-06 27.2 0.0 5.1 7.0 0.0 5.7 6 0 0 6 6 6 2 Y_Y_Y domain Stress-antifung PF01657.15 T125311_1 - 0.089 13.3 0.0 0.27 11.8 0.0 1.8 1 0 0 1 1 1 0 Salt stress response/antifungal PKD_channel PF08016.10 T125311_2 - 7.9e-120 400.3 0.0 1e-119 399.9 0.0 1.1 1 0 0 1 1 1 1 Polycystin cation channel PLAT PF01477.21 T125311_2 - 1.1e-20 74.3 0.0 1.7e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 PLAT/LH2 domain LRR_8 PF13855.4 T125311_3 - 1e-10 41.1 4.3 1.7e-10 40.3 4.3 1.3 1 0 0 1 1 1 1 Leucine rich repeat PKD PF00801.18 T125311_3 - 3.2e-10 39.6 0.1 3.2e-10 39.6 0.1 2.2 2 0 0 2 2 2 1 PKD domain LRRCT PF01463.22 T125311_3 - 0.0085 16.4 0.1 0.0085 16.4 0.1 6.6 7 0 0 7 7 7 1 Leucine rich repeat C-terminal domain LRR_4 PF12799.5 T125311_3 - 0.066 13.5 4.9 0.28 11.5 4.9 2.0 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) Myc_N PF01056.16 T008710_1 - 7.3e-28 98.3 5.4 2.8e-27 96.3 5.4 1.7 1 1 0 1 1 1 1 Myc amino-terminal region NCOA_u2 PF16665.3 T345645_3 - 7.4e-37 126.1 17.6 7.4e-37 126.1 17.6 4.2 3 1 0 3 3 3 1 Unstructured region on nuclear receptor coactivator protein PAS_11 PF14598.4 T345645_3 - 2.3e-36 124.2 0.7 1.6e-33 115.0 1.1 2.6 2 0 0 2 2 2 2 PAS domain DUF4927 PF16279.3 T345645_3 - 8.5e-32 109.9 5.9 2.2e-31 108.6 5.9 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4927) DUF1518 PF07469.10 T345645_3 - 3.5e-25 88.0 19.7 3.5e-25 88.0 19.7 4.0 3 1 0 3 3 3 1 Domain of unknown function (DUF1518) Nuc_rec_co-act PF08815.8 T345645_3 - 1.5e-24 85.5 0.8 3.1e-24 84.5 0.8 1.6 1 0 0 1 1 1 1 Nuclear receptor coactivator SRC-1 PF08832.8 T345645_3 - 3.9e-20 72.6 5.8 3.9e-20 72.6 5.8 3.3 4 0 0 4 4 4 1 Steroid receptor coactivator PAS PF00989.23 T345645_3 - 2.8e-07 30.4 0.4 9.9e-07 28.6 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.10 T345645_3 - 6.6e-07 29.4 0.1 0.035 14.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.5 T345645_3 - 0.0001 22.4 0.0 0.00028 21.0 0.0 1.7 1 0 0 1 1 1 1 PAS domain HLH PF00010.24 T345645_3 - 0.053 13.4 0.7 0.11 12.4 0.7 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Lig_chan PF00060.24 T224898_2 - 1e-25 90.2 0.0 1.5e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel Gelsolin PF00626.20 T240243_1 - 6.6e-72 237.3 0.0 1.8e-13 50.0 0.0 6.3 6 0 0 6 6 6 6 Gelsolin repeat VHP PF02209.17 T240243_1 - 1.6e-13 50.4 2.9 3.9e-13 49.1 2.9 1.7 1 0 0 1 1 1 1 Villin headpiece domain Homeobox PF00046.27 T215500_2 - 0.0046 16.6 2.8 0.0073 16.0 2.8 1.3 1 0 0 1 1 1 1 Homeobox domain HCO3_cotransp PF00955.19 T212897_2 - 1.3e-145 486.0 1.8 1.8e-145 485.6 1.8 1.1 1 0 0 1 1 1 1 HCO3- transporter family PTS_EIIA_2 PF00359.20 T212897_2 - 0.0019 18.0 0.0 0.0047 16.7 0.0 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 SH2 PF00017.22 T086468_2 - 1.3e-13 50.6 0.0 2.2e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 T086468_2 - 9.2e-05 22.8 0.0 0.00017 21.9 0.0 1.4 1 0 0 1 1 1 1 PH domain Phe_ZIP PF08916.9 T086468_3 - 1.7e-21 76.6 3.0 3.2e-21 75.7 3.0 1.5 1 0 0 1 1 1 1 Phenylalanine zipper Tom37 PF10568.7 T284831_1 - 8.8e-37 126.1 0.0 1.4e-36 125.5 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.2 T284831_1 - 3.5e-22 77.8 0.3 8.5e-22 76.6 0.3 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.2 T284831_1 - 8.3e-15 55.2 0.0 1.5e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.4 T284831_1 - 4.6e-06 26.4 0.0 9.7e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain AdoMet_MTase PF07757.11 T260840_2 - 2.3e-40 137.3 0.0 4e-40 136.5 0.0 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase 4F5 PF04419.12 T115692_3 - 2.8e-10 40.8 10.8 2.8e-10 40.8 10.8 2.3 2 0 0 2 2 2 1 4F5 protein family Collagen PF01391.16 T269376_2 - 7.4e-62 204.9 255.2 2.1e-09 36.8 26.3 8.4 3 2 5 8 8 8 8 Collagen triple helix repeat (20 copies) MAGE_N PF12440.6 T269376_3 - 0.36 11.4 1.2 0.61 10.7 1.2 1.4 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal LRR_8 PF13855.4 T236977_3 - 2.5e-37 126.3 36.4 3.2e-14 52.3 5.6 6.4 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 T236977_3 - 5.6e-20 70.9 40.4 3e-05 24.1 3.3 7.5 2 1 9 11 11 11 10 Leucine Rich repeats (2 copies) I-set PF07679.14 T236977_3 - 8e-16 57.8 0.0 2e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T236977_3 - 4.4e-12 46.3 0.0 9.7e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.4 T236977_3 - 1.8e-10 40.5 23.7 0.0024 17.3 3.4 4.2 1 1 3 4 4 4 4 Leucine-rich repeat ig PF00047.23 T236977_3 - 1.9e-07 31.0 0.4 5e-07 29.7 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 T236977_3 - 4.8e-07 29.9 0.0 1.2e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRRNT PF01462.16 T236977_3 - 0.0024 17.3 1.1 0.0024 17.3 1.1 3.3 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain V-set PF07686.15 T236977_3 - 0.0028 17.7 0.1 0.013 15.5 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRRCT PF01463.22 T236977_3 - 0.004 17.5 0.1 0.013 15.9 0.1 2.0 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain Pur_ac_phosph_N PF16656.3 T236977_3 - 0.012 16.0 1.8 0.024 15.0 1.8 1.4 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain fn3 PF00041.19 T236977_3 - 0.014 15.6 2.0 0.023 14.9 2.0 1.3 1 0 0 1 1 1 0 Fibronectin type III domain zf-C3HC4 PF00097.23 T032350_1 - 1.8e-07 30.8 3.6 1.8e-07 30.8 3.6 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T032350_1 - 4e-07 29.9 5.6 4e-07 29.9 5.6 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 T032350_1 - 5.4e-05 22.8 5.9 0.00036 20.2 5.9 2.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T032350_1 - 0.00086 19.0 10.0 0.0011 18.7 7.2 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T032350_1 - 0.0012 18.6 4.7 0.0012 18.6 4.7 2.8 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.4 T032350_1 - 0.0031 17.6 6.4 0.0031 17.6 6.4 3.2 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_5 PF17121.3 T032350_1 - 0.083 12.7 4.5 0.31 10.8 4.5 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vps5 PF09325.8 T117977_1 - 5.1e-82 274.8 22.6 7.6e-82 274.3 22.6 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.22 T117977_1 - 3.7e-27 94.4 0.0 6.6e-27 93.6 0.0 1.4 1 0 0 1 1 1 1 PX domain Sorting_nexin PF03700.11 T117977_1 - 5.7e-21 75.3 7.9 1.1e-20 74.3 7.9 1.4 1 0 0 1 1 1 1 Sorting nexin, N-terminal domain BAR_3_WASP_bdg PF10456.7 T117977_1 - 0.0017 17.7 3.4 0.0067 15.8 3.1 1.8 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein FUSC PF04632.10 T117977_1 - 3 6.2 6.8 4.3 5.6 6.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family CitMHS PF03600.14 T086409_2 - 0.0014 17.8 0.0 0.0014 17.8 0.0 2.4 2 1 0 2 2 2 1 Citrate transporter Wzy_C PF04932.13 T086409_2 - 2.5 7.6 5.4 6.1 6.3 5.4 1.6 1 0 0 1 1 1 0 O-Antigen ligase zf-CCCH PF00642.22 T366109_1 - 1.1e-06 28.3 1.9 4.9e-06 26.2 1.9 2.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_UBOX PF13445.4 T366109_1 - 2.3e-05 24.2 7.7 2.3e-05 24.2 7.7 3.2 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.4 T366109_1 - 2.5e-05 24.0 7.8 2.5e-05 24.0 7.8 2.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 T366109_1 - 4.5e-05 23.5 7.3 4.5e-05 23.5 7.3 4.6 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_4 PF15227.4 T366109_1 - 0.00071 19.5 6.6 0.0051 16.8 6.6 2.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.4 T366109_1 - 0.00086 19.0 10.9 0.012 15.3 8.0 3.4 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.4 T366109_1 - 0.012 15.3 7.8 0.066 12.9 7.8 2.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Xin PF08043.10 T366109_1 - 0.031 13.8 0.0 0.077 12.6 0.0 1.7 1 0 0 1 1 1 0 Xin repeat ACTH_domain PF00976.16 T228101_2 - 1.9 8.3 18.9 12 5.9 1.6 4.1 3 0 0 3 3 3 0 Corticotropin ACTH domain KH_1 PF00013.27 T228101_3 - 2.3e-53 177.7 13.9 2.8e-18 65.3 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 T228101_3 - 6.5e-13 48.2 7.0 0.00013 21.6 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 T228101_3 - 2e-06 27.4 1.1 0.03 14.1 0.3 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 T228101_3 - 0.0016 18.4 7.9 2.1 8.3 0.2 3.3 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.3 T228101_3 - 0.035 14.0 0.0 0.22 11.4 0.0 2.2 3 0 0 3 3 3 0 KH-like RNA-binding domain Mito_carr PF00153.25 T156565_3 - 3.2e-42 142.2 0.6 1.6e-15 56.7 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L12 PF00542.17 T156565_3 - 9.5e-16 57.8 7.7 9.5e-16 57.8 7.7 1.6 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.3 T156565_3 - 1e-09 37.9 0.8 1e-09 37.9 0.8 2.7 3 0 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain MmgE_PrpD PF03972.12 T096421_1 - 1.5e-107 359.8 0.0 1.9e-107 359.4 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family HOIP-UBA PF16678.3 T101705_1 - 4.2e-51 172.8 0.1 6.6e-51 172.2 0.1 1.3 1 0 0 1 1 1 1 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase PUB PF09409.8 T101705_1 - 3.6e-13 49.1 0.0 6.3e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 PUB domain IBR PF01485.19 T101705_1 - 3.2e-07 30.4 7.2 3.2e-07 30.4 7.2 7.2 6 2 1 7 7 7 3 IBR domain, a half RING-finger domain zf-RanBP PF00641.16 T101705_1 - 4.9e-05 22.4 33.1 0.0022 17.2 0.9 5.2 4 0 0 4 4 4 3 Zn-finger in Ran binding protein and others IRF PF00605.15 T101705_2 - 2.9e-36 123.8 0.2 5e-36 123.0 0.2 1.4 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor IRF-3 PF10401.7 T101705_2 - 1.7e-26 93.0 0.0 2.5e-26 92.5 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 Rad21_Rec8_N PF04825.11 T101705_3 - 5.3e-23 81.2 0.0 8.8e-23 80.4 0.0 1.3 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.14 T101705_3 - 2.5e-19 68.2 0.0 4.3e-19 67.5 0.0 1.4 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein IRF-3 PF10401.7 T101705_3 - 4.8e-09 36.1 0.0 7.4e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 HAP1_N PF04849.11 T087580_1 - 7.2 5.6 68.2 1.7 7.6 47.3 3.7 1 1 1 2 2 2 0 HAP1 N-terminal conserved region zf-AN1 PF01428.14 T346860_3 - 1.1e-21 76.6 18.2 2.8e-11 43.3 10.6 2.7 2 0 0 2 2 2 2 AN1-like Zinc finger zf-C5HC2 PF02928.14 T346860_3 - 0.24 11.7 13.2 0.94 9.8 1.8 3.6 3 0 0 3 3 3 0 C5HC2 zinc finger IL15 PF02372.13 T272187_1 - 1.2e-53 180.6 3.6 1.9e-53 179.9 3.6 1.3 1 0 0 1 1 1 1 Interleukin 15 CYLD_phos_site PF16607.3 T132202_3 - 2.3e-90 300.6 6.9 3.2e-90 300.2 6.9 1.2 1 0 0 1 1 1 1 Phosphorylation region of CYLD, unstructured CAP_GLY PF01302.23 T132202_3 - 4.4e-34 116.2 2.6 1.2e-13 50.7 0.0 3.3 3 0 0 3 3 3 3 CAP-Gly domain UCH PF00443.27 T132202_3 - 5.3e-09 35.8 0.1 8.5e-09 35.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.30 T316200_2 - 1.6e-05 25.4 0.1 0.0051 17.5 0.0 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40 PF00400.30 T316200_3 - 2.7e-14 53.2 3.7 3.9e-07 30.5 0.3 5.9 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T316200_3 - 0.0022 18.1 0.0 1.1 9.5 0.0 3.9 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain RUN PF02759.17 T207544_1 - 2.9e-08 33.6 1.8 3.3e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 RUN domain ERM PF00769.17 T207544_1 - 0.00031 20.5 12.0 0.0005 19.8 12.0 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family DUF812 PF05667.9 T207544_1 - 0.0034 16.2 8.4 0.0048 15.7 8.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Spc7 PF08317.9 T207544_1 - 0.0069 15.2 20.0 0.01 14.6 20.0 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein HAUS2 PF15003.4 T207544_1 - 0.0097 15.5 6.9 0.015 14.9 6.9 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 DUF4407 PF14362.4 T207544_1 - 0.017 14.4 6.7 0.026 13.8 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GAS PF13851.4 T207544_1 - 0.043 13.1 16.0 0.068 12.4 16.0 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF342 PF03961.11 T207544_1 - 0.32 9.4 5.7 0.48 8.8 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TPR_MLP1_2 PF07926.10 T207544_1 - 0.4 10.6 27.0 0.62 10.0 27.0 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein MPS2 PF17060.3 T207544_1 - 0.46 9.5 9.6 0.67 9.0 9.6 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 FH2 PF02181.21 T207544_1 - 0.7 8.8 6.0 1.1 8.2 6.0 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain IncA PF04156.12 T207544_1 - 0.71 9.5 27.1 1.1 8.9 27.1 1.2 1 0 0 1 1 1 0 IncA protein APG6 PF04111.10 T207544_1 - 3.4 6.8 14.1 5.6 6.1 14.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 LCD1 PF09798.7 T207544_1 - 5.9 5.1 8.4 8.4 4.6 8.4 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein AAA_23 PF13476.4 T207544_1 - 8.2 6.7 7.3 15 5.9 7.3 1.3 1 0 0 1 1 1 0 AAA domain Spc24 PF08286.9 T207544_1 - 8.8 6.5 7.1 16 5.6 7.1 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 zf-C3HC4_3 PF13920.4 T207544_2 - 0.85 9.4 7.1 2.2 8.1 7.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pkinase_Tyr PF07714.15 T222431_1 - 2.6e-99 331.6 0.0 1.8e-88 296.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.23 T222431_1 - 1.5e-53 181.8 0.0 1.5e-47 162.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain SH2 PF00017.22 T222431_1 - 3.5e-17 62.1 0.0 5.9e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 T222431_1 - 1.5e-07 30.8 0.2 3.2e-07 29.7 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 T222431_1 - 6e-07 29.1 0.1 1.4e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 T222431_1 - 6e-06 25.7 0.0 1.4e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Pkinase_Tyr PF07714.15 T222431_2 - 4.9e-63 212.7 0.0 6.8e-63 212.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T222431_2 - 4.6e-24 85.1 0.0 6.7e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T222431_3 - 0.041 13.0 0.0 0.061 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Myosin_head PF00063.19 T167592_1 - 7.4e-248 824.1 0.0 8.8e-248 823.8 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) zf-C2H2_8 PF15909.3 T167592_1 - 6.6e-57 189.7 12.1 1.4e-56 188.7 12.1 1.6 1 0 0 1 1 1 1 C2H2-type zinc ribbon Myosin_TH1 PF06017.11 T167592_1 - 1.4e-51 174.6 0.0 2.2e-51 174.0 0.0 1.3 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_9 PF14604.4 T167592_1 - 1.1e-13 50.6 0.2 2.4e-13 49.6 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T167592_1 - 2.2e-13 49.4 0.2 6.2e-13 48.0 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 T167592_1 - 4.4e-11 42.2 0.1 1.2e-10 40.8 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain zf-H2C2_5 PF13909.4 T167592_1 - 0.03 13.9 1.8 0.045 13.4 0.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc-finger domain IQ PF00612.25 T167592_1 - 5.6 6.9 5.9 1.3 8.9 1.2 2.6 2 0 0 2 2 2 0 IQ calmodulin-binding motif zf-C2H2_6 PF13912.4 T167592_1 - 7 6.6 11.7 2 8.3 0.2 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger Pep_M12B_propep PF01562.17 T167592_2 - 6e-31 107.4 0.0 1.1e-30 106.6 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide hSH3 PF14603.4 T167592_2 - 5e-30 103.8 0.0 8.5e-30 103.0 0.0 1.3 1 0 0 1 1 1 1 Helically-extended SH3 domain Reprolysin PF01421.17 T167592_2 - 8.3e-23 81.2 0.0 1.2e-22 80.6 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 T167592_2 - 1.2e-12 48.3 0.2 2.2e-12 47.4 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T167592_2 - 1.7e-10 41.4 0.1 2.6e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T167592_2 - 4.7e-09 36.3 0.2 7.5e-09 35.6 0.2 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like TSP_1 PF00090.17 T167592_2 - 1.7e-06 28.0 9.7 1.7e-06 28.0 9.7 2.9 2 0 0 2 2 2 1 Thrombospondin type 1 domain Reprolysin_4 PF13583.4 T167592_2 - 3.4e-06 26.7 0.1 5.8e-06 26.0 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like SH3_2 PF07653.15 T167592_2 - 0.0053 16.3 0.0 0.014 15.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain ADAM_spacer1 PF05986.12 T167592_3 - 8.1e-24 83.7 0.0 1.2e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 PLAC PF08686.9 T167592_3 - 2.4e-08 34.4 11.0 7.5e-08 32.8 11.0 2.0 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain TSP_1 PF00090.17 T167592_3 - 4.4e-07 29.9 54.8 0.0069 16.4 11.0 6.0 5 0 0 5 5 5 4 Thrombospondin type 1 domain Orai-1 PF07856.10 T130524_1 - 8e-08 32.0 1.5 1.1e-07 31.6 1.5 1.2 1 0 0 1 1 1 1 Mediator of CRAC channel activity 3Beta_HSD PF01073.17 T130524_2 - 4e-93 311.3 0.0 5.5e-93 310.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 T130524_2 - 8.6e-23 80.9 0.0 1.4e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family N-SET PF11764.6 T130524_2 - 6.1e-22 78.4 2.8 6.1e-22 78.4 2.8 5.0 4 2 0 4 4 2 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.26 T130524_2 - 1e-14 55.2 0.2 1e-14 55.2 0.2 2.9 2 0 0 2 2 2 1 SET domain GDP_Man_Dehyd PF16363.3 T130524_2 - 2.2e-14 53.4 0.0 3.5e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.10 T130524_2 - 1.7e-12 47.0 0.1 1.3e-11 44.0 0.1 2.0 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.4 T130524_2 - 8.8e-10 38.7 0.0 1.5e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.8 T130524_2 - 7.1e-08 32.4 0.0 1.4e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.13 T130524_2 - 2.9e-07 29.8 0.0 4.4e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.15 T130524_2 - 1.1e-05 24.6 0.0 1.8e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain RRM_1 PF00076.20 T130524_2 - 1.4e-05 24.7 0.0 2.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NmrA PF05368.11 T130524_2 - 0.00087 18.8 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.23 T130524_2 - 0.0013 18.1 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.16 T130524_2 - 0.041 14.0 0.1 0.16 12.1 0.1 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain PHD_4 PF16866.3 T130524_3 - 1.4e-24 85.8 6.4 1.4e-24 85.8 6.4 2.7 2 0 0 2 2 2 1 PHD-finger zf-CXXC PF02008.18 T130524_3 - 9.7e-13 47.8 21.7 9.7e-13 47.8 21.7 3.0 4 0 0 4 4 4 1 CXXC zinc finger domain F-box PF00646.31 T130524_3 - 1.8e-08 33.9 2.5 1.8e-08 33.9 2.5 2.3 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.5 T130524_3 - 8.8e-06 25.4 4.7 3.3e-05 23.6 4.7 2.1 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.5 T130524_3 - 0.019 15.2 1.0 3.8 7.9 0.1 2.8 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 T130524_3 - 0.098 12.6 0.1 1.1e+02 3.1 0.0 4.0 3 0 0 3 3 3 0 Leucine Rich repeat LRR_8 PF13855.4 T130524_3 - 2.7 7.7 4.0 35 4.1 0.0 3.0 3 0 0 3 3 3 0 Leucine rich repeat WD40 PF00400.30 T316176_1 - 7.6e-08 32.8 0.1 1.7e-06 28.5 0.1 2.8 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T316176_1 - 0.084 13.0 0.0 0.29 11.3 0.0 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 T316176_2 - 6.4e-09 36.2 0.4 0.0045 17.7 0.0 5.5 4 0 0 4 4 4 3 WD domain, G-beta repeat NUDIX PF00293.26 T136488_2 - 1.8e-09 37.6 0.1 2.4e-09 37.2 0.1 1.3 1 1 0 1 1 1 1 NUDIX domain DHC_N2 PF08393.11 T128507_2 - 4.7e-12 45.6 0.0 6.6e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 ARL2_Bind_BART PF11527.6 T128507_3 - 0.027 14.5 2.3 0.035 14.1 0.3 2.2 2 0 0 2 2 2 0 The ARF-like 2 binding protein BART DUF2935 PF11155.6 T128507_3 - 0.12 12.6 3.3 0.13 12.5 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) CCDC50_N PF15295.4 T257073_2 - 3.4e-49 166.1 38.5 1.7e-45 154.1 24.4 2.2 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 50 N-terminus E1-E2_ATPase PF00122.18 T173780_1 - 2.5e-47 160.9 2.1 2.5e-47 160.9 0.5 1.7 1 1 1 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.24 T173780_1 - 9.9e-08 31.4 0.0 1.6e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.4 T173780_2 - 1.3e-22 79.6 0.0 1.9e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_C PF00689.19 T173780_3 - 5.8e-40 136.8 0.5 7.5e-40 136.4 0.5 1.1 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.24 T173780_3 - 1.1e-08 35.5 0.2 3.4e-06 27.4 0.1 2.7 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 T173780_3 - 0.00028 20.6 1.0 0.00041 20.0 1.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase TOM_sub5 PF15178.4 T283810_2 - 2.1e-22 78.7 0.6 3.2e-22 78.1 0.6 1.3 1 0 0 1 1 1 1 Mitochondrial import receptor subunit TOM5 homolog Tom5 PF10642.7 T283810_2 - 0.12 12.2 0.4 0.3 11.0 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase 4F5 PF04419.12 T283810_3 - 1.2e-07 32.4 9.4 2.3e-07 31.5 9.4 1.4 1 0 0 1 1 1 1 4F5 protein family Tmemb_14 PF03647.11 T297302_3 - 0.0002 21.9 11.3 0.002 18.7 1.9 2.4 1 1 1 2 2 2 2 Transmembrane proteins 14C 7tm_1 PF00001.19 T315293_3 - 4e-47 160.6 21.0 6.6e-47 159.8 21.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) E1-E2_ATPase PF00122.18 T315293_3 - 0.64 9.2 1.9 1.4 8.0 1.9 1.4 1 0 0 1 1 1 0 E1-E2 ATPase Guanylate_cyc PF00211.18 T141231_1 - 5.2e-62 208.6 0.0 7.5e-62 208.1 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.26 T141231_1 - 6.4e-42 143.8 0.0 8.9e-42 143.3 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Pkinase_Tyr PF07714.15 T141231_1 - 2.2e-26 92.6 0.0 3.5e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T141231_1 - 1.6e-22 80.0 0.0 2.5e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HNOBA PF07701.12 T141231_1 - 2.1e-05 23.9 1.1 3.4e-05 23.3 1.1 1.3 1 0 0 1 1 1 1 Heme NO binding associated Kinase-like PF14531.4 T141231_1 - 0.002 17.3 0.0 0.0032 16.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RVT_1 PF00078.25 T211443_1 - 9.9e-23 80.7 0.0 1.7e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Rootletin PF15035.4 T211443_1 - 1.6e-17 64.1 10.3 1.6e-17 64.1 10.3 4.8 2 2 2 4 4 4 1 Ciliary rootlet component, centrosome cohesion Ribonuc_2-5A PF06479.10 T129010_2 - 6.9e-40 136.0 0.1 1e-39 135.4 0.1 1.3 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.23 T129010_2 - 1.3e-37 129.5 0.0 1.7e-37 129.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T129010_2 - 5.4e-18 65.1 0.0 7.7e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.4 T129010_2 - 5.4e-05 22.8 0.0 0.046 13.2 0.0 2.7 1 1 1 2 2 2 2 PQQ-like domain PQQ_3 PF13570.4 T129010_2 - 0.0037 17.5 0.2 17 5.9 0.0 4.2 3 0 0 3 3 3 1 PQQ-like domain APH PF01636.21 T129010_2 - 0.045 13.5 4.3 0.25 11.1 0.1 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.12 T129010_2 - 0.14 11.4 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CD225 PF04505.10 T215420_3 - 2.3e-19 69.1 0.7 3.1e-18 65.5 0.1 2.4 2 0 0 2 2 2 1 Interferon-induced transmembrane protein HLH PF00010.24 T326296_3 - 7.9e-13 48.0 0.1 1.9e-12 46.8 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Atg14 PF10186.7 T326296_3 - 0.005 15.8 2.1 0.0088 15.0 2.1 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 ZapB PF06005.10 T326296_3 - 0.18 12.1 3.0 0.36 11.2 3.0 1.4 1 0 0 1 1 1 0 Cell division protein ZapB DUF3584 PF12128.6 T326296_3 - 0.21 8.9 2.0 0.27 8.5 2.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TolA_bind_tri PF16331.3 T326296_3 - 0.32 11.0 5.8 0.59 10.1 5.8 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation NUDE_C PF04880.11 T326296_3 - 0.4 11.0 0.0 0.4 11.0 0.0 2.2 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region bZIP_1 PF00170.19 T326296_3 - 0.51 10.3 2.2 0.91 9.5 2.2 1.3 1 0 0 1 1 1 0 bZIP transcription factor DivIC PF04977.13 T326296_3 - 0.93 9.2 3.9 1.6 8.4 3.9 1.3 1 0 0 1 1 1 0 Septum formation initiator Shadoo PF14999.4 T326296_3 - 2.6 8.0 6.8 0.55 10.2 3.1 1.7 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective C2 PF00168.28 T041189_1 - 1.5e-25 89.3 0.6 2.1e-14 53.5 0.0 2.3 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.4 T041189_1 - 0.04 13.4 0.1 0.096 12.1 0.1 1.5 1 0 0 1 1 1 0 CEP76 C2 domain HLH PF00010.24 T210836_1 - 4.3e-16 58.5 0.6 8.7e-16 57.5 0.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF773 PF05600.10 T210836_1 - 0.17 10.5 0.4 0.23 10.0 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF773) Arm PF00514.21 T038881_2 - 3.3e-44 147.5 21.0 3.6e-06 26.7 0.0 11.6 11 0 0 11 11 11 10 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 T038881_2 - 1.9e-19 69.7 3.2 1.3e-05 25.3 0.0 6.5 3 2 2 6 6 6 4 HEAT repeats HEAT_EZ PF13513.4 T038881_2 - 1.7e-10 41.0 8.5 0.0017 18.6 0.3 7.6 6 3 3 9 9 9 4 HEAT-like repeat HEAT PF02985.20 T038881_2 - 3.1e-09 36.2 11.8 0.55 10.5 0.1 8.1 8 0 0 8 8 8 3 HEAT repeat Adaptin_N PF01602.18 T038881_2 - 7.7e-09 34.5 6.3 1.8e-05 23.4 0.2 3.1 2 1 1 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.5 T038881_2 - 6.5e-08 32.6 5.8 0.038 13.9 0.1 4.8 2 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.6 T038881_2 - 3.5e-07 30.2 9.6 1.7 8.7 0.5 6.7 5 2 2 7 7 7 2 V-ATPase subunit H UNC45-central PF11701.6 T038881_2 - 4.4e-07 29.8 0.7 0.21 11.4 0.1 3.9 2 1 1 3 3 3 2 Myosin-binding striated muscle assembly central KAP PF05804.10 T038881_2 - 1.6e-06 26.5 1.4 0.0067 14.5 0.3 2.2 2 0 0 2 2 2 2 Kinesin-associated protein (KAP) DUF727 PF05303.10 T038881_2 - 0.0025 17.7 0.0 0.009 15.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF727) RasGEF_N_2 PF14663.4 T038881_2 - 0.0053 16.9 12.5 6.1 7.1 0.0 6.1 5 1 2 7 7 7 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain V-ATPase_H_N PF03224.12 T038881_2 - 0.0084 15.3 0.3 3.1 6.9 0.1 3.0 2 1 0 2 2 2 2 V-ATPase subunit H Vac14_Fab1_bd PF12755.5 T038881_2 - 0.093 13.2 0.1 21 5.6 0.0 3.5 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region cNMP_binding PF00027.27 T167258_3 - 2.7e-51 171.4 0.1 7.2e-17 61.1 0.0 3.6 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Patatin PF01734.20 T167258_3 - 2e-23 83.5 0.1 3.8e-23 82.6 0.1 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase PCRF PF03462.16 T313840_1 - 4e-40 137.6 0.7 6.7e-40 136.9 0.7 1.3 1 0 0 1 1 1 1 PCRF domain RF-1 PF00472.18 T313840_1 - 1.9e-38 130.8 2.9 3.1e-38 130.1 2.9 1.3 1 0 0 1 1 1 1 RF-1 domain EssA PF10661.7 T313840_1 - 0.23 11.2 0.6 0.37 10.5 0.6 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA F-box PF00646.31 T313840_2 - 0.00013 21.6 0.1 0.00031 20.4 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 T313840_2 - 0.035 13.8 0.0 0.098 12.4 0.0 1.7 1 0 0 1 1 1 0 F-box-like RGS PF00615.17 T313840_3 - 2.5e-16 59.9 0.1 5e-16 58.9 0.1 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain Ig_2 PF13895.4 T022946_2 - 3.8e-24 84.7 0.0 1.6e-06 28.2 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 T022946_2 - 2.8e-23 82.2 0.0 1.2e-07 32.1 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 T022946_2 - 6.6e-16 58.1 0.0 7.4e-06 25.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 T022946_2 - 1.2e-10 41.2 0.0 4.4e-05 23.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain V-set PF07686.15 T022946_2 - 0.0082 16.2 0.1 9.2 6.3 0.0 4.2 3 2 2 5 5 5 1 Immunoglobulin V-set domain CUB PF00431.18 T337891_3 - 1.2e-21 77.0 0.0 1.8e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 CUB domain Sushi PF00084.18 T337891_3 - 2.7e-08 34.2 0.0 4.7e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) zf-MIZ PF02891.18 T322865_3 - 1.4e-22 79.1 4.5 1.4e-22 79.1 4.5 2.8 3 0 0 3 3 3 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 T322865_3 - 1e-05 25.1 1.1 4.2e-05 23.1 1.1 2.1 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Peptidase_M16 PF00675.18 T330410_1 - 1.6e-56 190.3 0.2 2.5e-56 189.7 0.2 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 T330410_1 - 8.8e-37 126.8 0.0 5.2e-36 124.2 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain CHDCT2 PF08074.9 T141169_1 - 9.7e-18 64.8 0.0 1.5e-17 64.2 0.0 1.2 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain CHDCT2 PF08074.9 T141169_3 - 2.8e-63 213.0 0.5 6e-63 212.0 0.5 1.5 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF1086 PF06461.9 T141169_3 - 1e-61 206.7 0.0 2.9e-61 205.2 0.0 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.21 T141169_3 - 4.1e-61 206.5 0.0 8.8e-61 205.4 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain CHDNT PF08073.10 T141169_3 - 3.3e-26 90.8 0.4 7.3e-26 89.7 0.4 1.6 1 0 0 1 1 1 1 CHDNT (NUC034) domain DUF1087 PF06465.11 T141169_3 - 7.4e-25 86.7 6.6 7.4e-25 86.7 6.6 2.7 3 0 0 3 3 1 1 Domain of Unknown Function (DUF1087) Helicase_C PF00271.29 T141169_3 - 1.5e-21 76.7 0.0 2.7e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 T141169_3 - 4e-20 71.3 26.4 2e-10 40.2 7.3 2.5 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.22 T141169_3 - 4.6e-19 67.9 6.8 1e-13 50.8 2.5 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 T141169_3 - 2.3e-08 34.1 0.0 6.1e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 T141169_3 - 6e-08 32.1 0.0 1.5e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 HMG_box PF00505.17 T141169_3 - 0.0041 17.4 0.2 0.0041 17.4 0.2 2.2 2 0 0 2 2 1 1 HMG (high mobility group) box DEAD PF00270.27 T141169_3 - 0.0078 15.9 0.0 0.023 14.4 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase PHD_2 PF13831.4 T141169_3 - 0.071 12.5 11.5 0.32 10.4 3.1 2.7 2 0 0 2 2 2 0 PHD-finger AAA_22 PF13401.4 T141169_3 - 0.16 12.1 0.0 0.57 10.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain zf-PHD-like PF15446.4 T141169_3 - 3.5 7.1 15.1 1 8.8 0.5 3.0 1 1 2 3 3 3 0 PHD/FYVE-zinc-finger like domain PHD PF00628.27 T336199_1 - 5.7e-39 131.7 132.8 1.2e-09 37.7 6.8 10.2 5 2 4 9 9 9 6 PHD-finger FYRC PF05965.12 T336199_1 - 2.6e-23 81.8 0.0 9.2e-23 80.1 0.0 2.1 1 0 0 1 1 1 1 F/Y rich C-terminus FYRN PF05964.12 T336199_1 - 1.9e-20 72.3 0.1 4.2e-20 71.2 0.1 1.6 1 0 0 1 1 1 1 F/Y-rich N-terminus SET PF00856.26 T336199_1 - 4.9e-18 65.9 0.2 4.9e-18 65.9 0.2 3.7 3 0 0 3 3 3 1 SET domain zf-HC5HC2H PF13771.4 T336199_1 - 2.5e-14 53.2 25.9 1.4e-09 37.9 9.3 9.6 4 2 4 8 8 8 3 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 T336199_1 - 5.5e-14 52.1 26.8 2.9e-10 40.2 8.9 8.4 3 2 5 8 8 8 3 PHD-zinc-finger like domain HMG_box PF00505.17 T336199_1 - 0.00011 22.4 0.1 0.00011 22.4 0.1 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box Arm PF00514.21 T328998_3 - 1.4e-73 240.8 21.9 1.2e-11 44.1 0.2 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 T328998_3 - 5.9e-24 84.0 11.6 5.7e-07 29.7 0.2 6.3 5 1 1 6 6 6 4 HEAT-like repeat Arm_3 PF16186.3 T328998_3 - 6.5e-20 70.3 0.9 4.6e-19 67.6 1.4 2.1 2 0 0 2 2 2 1 Atypical Arm repeat IBB PF01749.18 T328998_3 - 3.2e-19 68.9 0.3 8.1e-19 67.7 0.3 1.7 1 0 0 1 1 1 1 Importin beta binding domain HEAT_2 PF13646.4 T328998_3 - 2.4e-17 63.0 0.4 9.1e-05 22.6 0.0 5.4 1 1 4 5 5 5 5 HEAT repeats HEAT PF02985.20 T328998_3 - 2.1e-10 39.8 9.2 0.028 14.5 0.0 6.9 8 0 0 8 8 8 3 HEAT repeat Adaptin_N PF01602.18 T328998_3 - 1.1e-07 30.7 0.8 0.0011 17.5 0.0 2.2 1 1 1 2 2 2 2 Adaptin N terminal region HEAT_PBS PF03130.14 T328998_3 - 6.6e-06 26.2 3.7 2.6 8.8 0.0 5.5 5 1 0 5 5 4 1 PBS lyase HEAT-like repeat Arm_2 PF04826.11 T328998_3 - 2.8e-05 23.6 0.4 0.93 8.8 0.0 3.7 2 1 0 3 3 3 2 Armadillo-like V-ATPase_H_C PF11698.6 T328998_3 - 8.3e-05 22.6 0.6 2.8 8.0 0.0 4.2 4 1 1 5 5 5 2 V-ATPase subunit H V-ATPase_H_N PF03224.12 T328998_3 - 0.016 14.4 1.4 3.6 6.7 0.0 3.4 1 1 3 4 4 4 0 V-ATPase subunit H Sec7_N PF12783.5 T328998_3 - 0.024 14.5 0.2 4.4 7.1 0.1 2.8 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3361 PF11841.6 T328998_3 - 2.8 7.8 6.2 76 3.1 0.1 4.3 3 3 1 5 5 5 0 Domain of unknown function (DUF3361) FRG2 PF15315.4 T051833_2 - 2e-59 200.7 1.9 2e-59 200.7 1.9 2.3 2 0 0 2 2 2 1 Facioscapulohumeral muscular dystrophy candidate 2 FRG2 PF15315.4 T051833_3 - 2.1e-12 47.4 6.1 2.1e-12 47.4 6.1 2.2 2 0 0 2 2 2 1 Facioscapulohumeral muscular dystrophy candidate 2 zf-H2C2_5 PF13909.4 T172665_1 - 1.5e-06 27.7 1.6 3.8e-06 26.4 1.6 1.7 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 T172665_1 - 0.042 14.2 0.4 0.22 11.9 0.4 2.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_assoc PF16606.3 T172665_3 - 2.7e-40 136.3 16.8 2.7e-40 136.3 16.8 2.3 2 0 0 2 2 2 1 Unstructured conserved, between two C2H2-type zinc-fingers zf-C2H2 PF00096.24 T172665_3 - 7.4e-31 104.8 67.5 4.1e-05 23.7 4.0 9.9 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T172665_3 - 1.9e-22 77.8 74.8 0.004 17.7 2.8 11.0 10 0 0 10 10 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T172665_3 - 7e-16 57.7 89.0 1.7e-07 31.2 2.4 13.7 14 0 0 14 14 14 5 Zinc-finger double domain zf-H2C2_5 PF13909.4 T172665_3 - 1.7e-13 49.9 51.2 5.1e-07 29.2 0.9 9.5 9 0 0 9 9 9 3 C2H2-type zinc-finger domain zf-Di19 PF05605.10 T172665_3 - 4.5e-05 23.5 48.9 0.013 15.6 1.6 7.3 6 3 1 7 7 7 5 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.9 T172665_3 - 0.00061 19.4 5.5 1.3 8.8 0.1 5.1 4 1 1 5 5 5 1 GAGA factor DUF3268 PF11672.6 T172665_3 - 0.0044 17.2 8.8 0.062 13.5 1.2 3.5 3 0 0 3 3 3 2 zinc-finger-containing domain CpXC PF14353.4 T172665_3 - 0.18 11.7 22.2 19 5.2 0.5 6.5 4 3 1 5 5 5 0 CpXC protein Zn-ribbon_8 PF09723.8 T172665_3 - 0.94 9.5 34.1 1.6 8.7 3.8 6.1 5 1 0 5 5 5 0 Zinc ribbon domain zf-C2H2_2 PF12756.5 T172665_3 - 2.4 8.4 40.3 19 5.5 0.1 9.8 5 3 3 8 8 8 0 C2H2 type zinc-finger (2 copies) fn3 PF00041.19 T314421_2 - 1.2e-43 147.2 8.6 3.5e-10 39.9 0.0 5.6 5 0 0 5 5 5 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 T314421_2 - 3.2e-11 43.5 13.7 0.0019 18.6 0.1 5.1 5 0 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 T314421_2 - 4.7e-07 29.9 0.0 0.27 11.4 0.0 4.5 5 0 0 5 5 5 2 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.15 T314421_2 - 0.00016 21.3 1.8 0.0077 15.9 0.0 3.8 3 1 0 4 4 4 1 Tissue factor DUF2369 PF10179.7 T314421_2 - 0.00063 20.0 0.0 0.93 9.9 0.0 4.2 4 0 0 4 4 4 1 Uncharacterised conserved protein (DUF2369) Ets PF00178.20 T173814_1 - 6.9e-32 109.6 0.1 1.1e-31 109.0 0.1 1.3 1 0 0 1 1 1 1 Ets-domain EMP24_GP25L PF01105.22 T168362_1 - 1e-41 142.8 0.0 1.3e-41 142.5 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD fn3 PF00041.19 T094442_2 - 1.7e-88 290.9 0.1 6.6e-11 42.3 0.0 9.6 9 1 0 9 9 9 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 T094442_2 - 2.6e-15 56.6 8.8 0.55 10.7 0.0 8.3 6 3 0 6 6 6 5 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 T094442_2 - 3.1e-08 33.8 0.0 0.29 11.5 0.0 6.5 7 1 0 7 7 7 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 T094442_2 - 1.8e-06 28.0 2.3 0.17 12.1 0.0 5.6 6 0 0 6 6 6 2 Interferon-alpha/beta receptor, fibronectin type III Reeler PF02014.14 T094442_2 - 0.091 13.4 0.2 4 8.1 0.0 3.1 2 1 1 3 3 3 0 Reeler domain Integrin_beta PF00362.16 T227849_3 - 4.3e-116 386.7 0.0 5.8e-116 386.3 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 T227849_3 - 6.9e-16 57.5 0.5 1.1e-15 56.8 0.5 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 T227849_3 - 1.3e-15 57.5 2.4 1.3e-15 57.5 2.4 2.6 2 0 0 2 2 2 1 Integrin beta tail domain PSI_integrin PF17205.1 T227849_3 - 1.8e-12 46.8 12.3 3e-12 46.0 6.5 3.6 2 0 0 2 2 2 1 Integrin plexin domain 7tm_1 PF00001.19 T317108_1 - 1.7e-37 129.0 14.9 2.5e-37 128.4 14.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) C_tripleX PF02363.17 T317108_2 - 0.66 10.2 7.6 11 6.5 7.6 3.4 1 0 0 1 1 1 0 Cysteine rich repeat Connexin PF00029.17 T008472_1 - 3.9e-17 62.7 0.1 6.1e-17 62.0 0.1 1.2 1 0 0 1 1 1 1 Connexin Gtr1_RagA PF04670.10 T008472_2 - 3.2e-72 242.5 1.0 4.2e-72 242.1 1.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.19 T008472_2 - 0.00015 21.1 0.0 0.00024 20.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 T008472_2 - 0.00066 19.8 0.0 0.001 19.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 T008472_2 - 0.00095 18.5 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit TSC22 PF01166.16 T008472_2 - 0.037 14.2 0.7 0.083 13.1 0.7 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family Ras PF00071.20 T008472_2 - 0.13 11.7 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Ras family ZapB PF06005.10 T008472_2 - 0.93 9.8 4.7 1.6 9.1 4.7 1.3 1 0 0 1 1 1 0 Cell division protein ZapB Rhomboid PF01694.20 T008472_3 - 5e-33 114.0 3.7 8.2e-33 113.4 3.7 1.3 1 0 0 1 1 1 1 Rhomboid family DENN PF02141.19 T054523_3 - 1.3e-57 194.7 0.5 1.3e-57 194.7 0.5 1.8 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.16 T054523_3 - 7.2e-17 61.8 0.1 7.2e-17 61.8 0.1 2.2 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.17 T054523_3 - 1.4e-12 47.3 3.2 3.6e-12 45.9 3.2 1.8 1 0 0 1 1 1 1 dDENN domain Yae1_N PF09811.7 T106149_1 - 0.97 9.1 5.0 1.6 8.4 5.0 1.3 1 0 0 1 1 1 0 Essential protein Yae1, N terminal ATP-synt_D PF01813.15 T106149_2 - 3.2e-74 248.9 9.1 4.4e-74 248.4 9.1 1.2 1 0 0 1 1 1 1 ATP synthase subunit D Yae1_N PF09811.7 T106149_2 - 1.7 8.3 5.6 3.3 7.4 5.6 1.3 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Yae1_N PF09811.7 T106149_3 - 2.1 8.0 8.3 3.8 7.2 8.3 1.3 1 0 0 1 1 1 0 Essential protein Yae1, N terminal EGF PF00008.25 T211552_1 - 4.4e-56 186.6 171.0 1.6e-08 34.6 4.1 12.4 11 0 0 11 11 11 11 EGF-like domain hEGF PF12661.5 T211552_1 - 9.3e-32 108.5 169.4 1.9e-05 25.0 7.4 14.5 13 1 0 13 13 13 11 Human growth factor-like EGF NIDO PF06119.12 T211552_1 - 1.2e-25 90.2 0.3 2.2e-25 89.3 0.3 1.5 1 0 0 1 1 1 1 Nidogen-like EGF_2 PF07974.11 T211552_1 - 1.7e-08 34.5 200.6 0.012 15.8 12.4 12.9 13 0 0 13 13 13 10 EGF-like domain EGF_CA PF07645.13 T211552_1 - 0.0014 18.7 9.2 0.0014 18.7 9.2 11.6 6 4 5 11 11 11 5 Calcium-binding EGF domain cEGF PF12662.5 T211552_1 - 0.0027 17.5 0.7 0.0027 17.5 0.7 11.7 11 1 0 11 11 11 5 Complement Clr-like EGF-like fn3 PF00041.19 T211552_3 - 3.2e-33 113.8 3.2 1.7e-10 41.0 0.2 3.4 3 0 0 3 3 3 3 Fibronectin type III domain EGF PF00008.25 T211552_3 - 5.8e-23 80.7 90.6 2.7e-07 30.6 10.1 7.3 7 0 0 7 7 7 5 EGF-like domain EGF_2 PF07974.11 T211552_3 - 5.9e-05 23.2 102.0 0.01 16.0 8.0 7.9 7 0 0 7 7 7 5 EGF-like domain hEGF PF12661.5 T211552_3 - 0.00012 22.5 17.4 0.00044 20.7 5.9 7.9 8 0 0 8 8 8 4 Human growth factor-like EGF EGF_CA PF07645.13 T211552_3 - 0.00048 20.1 6.8 0.00048 20.1 6.8 6.5 3 1 3 6 6 6 2 Calcium-binding EGF domain Lig_chan PF00060.24 T154106_2 - 2.1e-35 121.6 0.6 3.3e-35 121.0 0.6 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 T154106_2 - 1.7e-27 95.7 0.0 4.4e-27 94.4 0.0 1.7 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 T154106_2 - 1.4e-23 83.4 0.0 2.1e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMDAR2_C PF10565.7 T154106_2 - 1.6e-10 40.5 0.0 2.1e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 N-methyl D-aspartate receptor 2B3 C-terminus ANF_receptor PF01094.26 T154106_2 - 4.6e-09 35.7 0.0 2.1e-08 33.6 0.0 1.9 1 1 0 1 1 1 1 Receptor family ligand binding region Gal-3-0_sulfotr PF06990.9 T211883_1 - 1.9e-183 609.8 0.5 2.7e-183 609.3 0.5 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.12 T211883_1 - 0.032 14.0 0.1 0.059 13.1 0.1 1.4 1 0 0 1 1 1 0 Sulfotransferase family Gal-3-0_sulfotr PF06990.9 T211883_3 - 0.0024 16.7 0.4 0.0033 16.3 0.4 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Troponin PF00992.18 T181150_2 - 7.2e-44 149.2 6.4 7.2e-44 149.2 6.4 1.9 2 0 0 2 2 2 1 Troponin Troponin-I_N PF11636.6 T181150_2 - 1.5e-14 53.4 12.7 1.5e-14 53.4 12.7 3.3 3 0 0 3 3 3 1 Troponin I residues 1-32 Tup_N PF08581.8 T181150_2 - 0.035 14.3 0.0 0.073 13.3 0.0 1.4 1 0 0 1 1 1 0 Tup N-terminal DUF919 PF06034.9 T181150_2 - 0.07 12.8 0.2 0.16 11.7 0.2 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF4471 PF14740.4 T181150_3 - 1.2e-103 346.4 0.0 1.7e-103 345.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) DUF4470 PF14737.4 T181150_3 - 3.7e-25 87.8 0.0 6.2e-25 87.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-RING_2 PF13639.4 T252281_3 - 4.2e-13 49.2 8.2 4.2e-13 49.2 8.2 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.3 T252281_3 - 2.5e-11 42.9 3.9 2.5e-11 42.9 3.9 2.3 2 0 0 2 2 2 1 RING-like zinc finger PA PF02225.20 T252281_3 - 7e-09 35.5 0.0 1.4e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-C3HC4_2 PF13923.4 T252281_3 - 1.7e-08 34.0 8.9 6.3e-08 32.2 8.9 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T252281_3 - 3.7e-08 33.0 8.4 1e-07 31.6 8.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T252281_3 - 8.4e-06 25.4 6.3 2.9e-05 23.7 6.3 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T252281_3 - 9.1e-06 25.4 6.9 2.3e-05 24.1 6.9 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.5 T252281_3 - 1.5e-05 25.1 9.1 6e-05 23.1 9.1 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 T252281_3 - 0.00044 20.1 5.1 0.0037 17.1 5.3 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 T252281_3 - 0.0009 19.1 2.5 0.0021 17.9 2.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 T252281_3 - 0.0098 15.6 6.7 0.0098 15.6 6.7 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 PHD PF00628.27 T252281_3 - 0.33 10.7 8.6 0.93 9.3 8.6 1.8 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.4 T252281_3 - 1.6 8.4 8.8 4.8 6.9 8.8 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Pkinase_Tyr PF07714.15 T356793_3 - 9e-92 306.9 0.0 1.4e-91 306.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T356793_3 - 4.6e-44 150.6 0.0 7.3e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_Tie2_1 PF10430.7 T356793_3 - 1.8e-39 133.9 1.0 3.1e-39 133.1 0.0 1.9 2 0 0 2 2 2 1 Tie-2 Ig-like domain 1 fn3 PF00041.19 T356793_3 - 4e-37 126.3 7.4 1.9e-13 50.4 0.3 3.4 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 T356793_3 - 5.7e-07 29.9 1.7 0.17 12.4 0.1 3.4 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.11 T356793_3 - 0.0018 18.5 10.8 0.0018 18.5 10.8 3.2 2 1 0 2 2 2 1 EGF-like domain fn3_2 PF16893.3 T356793_3 - 0.004 17.1 0.1 0.035 14.1 0.0 2.4 2 0 0 2 2 2 1 Fibronectin type III domain hEGF PF12661.5 T356793_3 - 0.0043 17.5 6.5 0.0043 17.5 6.5 3.3 3 0 0 3 3 2 1 Human growth factor-like EGF APH PF01636.21 T356793_3 - 0.0048 16.7 0.0 0.2 11.4 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family DUF2369 PF10179.7 T356793_3 - 0.072 13.4 0.0 0.74 10.2 0.0 2.5 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2369) Laminin_EGF PF00053.22 T356793_3 - 1.4 9.0 27.3 2.1 8.4 16.7 2.8 1 1 1 2 2 2 0 Laminin EGF domain zf-H2C2_2 PF13465.4 T174514_3 - 4.1e-68 222.8 108.6 8.1e-08 32.2 1.4 15.0 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 T174514_3 - 2.4e-39 131.5 105.0 7.6e-05 22.8 0.8 13.9 14 0 0 14 14 14 11 Zinc finger, C2H2 type KRAB PF01352.25 T174514_3 - 3.6e-22 77.6 0.1 6.3e-22 76.8 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T174514_3 - 5.4e-18 64.0 98.9 0.073 13.8 2.2 13.6 13 0 0 13 13 13 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T174514_3 - 4.8e-11 42.2 74.1 0.013 15.3 2.0 12.4 12 0 0 12 12 12 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T174514_3 - 2e-05 24.7 49.9 0.98 9.7 0.2 11.2 11 0 0 11 11 11 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T174514_3 - 0.24 11.4 72.6 0.71 9.9 5.8 8.5 6 2 2 8 8 8 0 Zinc ribbon domain Peptidase_S26 PF10502.7 T331192_3 - 0.00063 19.4 0.0 0.033 13.9 0.0 2.1 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.21 T331192_3 - 0.098 12.5 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase S24-like fn3 PF00041.19 T025481_2 - 3.5e-116 379.6 28.7 2e-15 56.8 1.0 9.4 9 0 0 9 9 9 9 Fibronectin type III domain Fibrinogen_C PF00147.16 T025481_2 - 7.3e-82 274.3 6.2 1.4e-81 273.4 6.2 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_2 PF07974.11 T025481_2 - 4.4e-15 55.6 85.5 0.00023 21.3 11.8 5.9 5 0 0 5 5 5 5 EGF-like domain Pur_ac_phosph_N PF16656.3 T025481_2 - 3.7e-08 33.7 18.2 2.1 8.9 0.0 9.0 8 1 1 9 9 9 3 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 T025481_2 - 8.3e-05 22.9 0.2 26 5.3 0.0 6.2 7 0 0 7 7 7 0 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 T025481_2 - 0.00023 21.3 0.0 9 6.5 0.0 6.1 8 0 0 8 8 8 1 Interferon-alpha/beta receptor, fibronectin type III CBM_4_9 PF02018.15 T025481_2 - 0.0095 16.0 0.3 3.4 7.8 0.0 4.0 2 1 1 4 4 4 1 Carbohydrate binding domain DUF4998 PF16389.3 T025481_2 - 0.011 15.2 0.0 19 4.7 0.0 3.8 3 1 0 4 4 4 0 Domain of unknown function Uroplakin_II PF07353.10 T025481_2 - 0.031 13.7 0.1 1.6 8.1 0.0 2.7 2 0 0 2 2 2 0 Uroplakin II Fascin PF06268.11 T317994_2 - 3.4e-124 407.0 0.5 2.7e-34 117.6 0.0 4.3 4 0 0 4 4 4 4 Fascin domain FRG1 PF06229.10 T317994_2 - 5.8e-14 52.1 0.0 0.0061 16.2 0.0 5.0 3 2 2 5 5 5 5 FRG1-like domain Bradykinin PF06753.10 T317994_3 - 0.24 11.0 11.5 2.3 7.9 1.1 3.6 2 0 0 2 2 2 0 Bradykinin Tubulin PF00091.23 T309728_2 - 2.6e-49 168.0 0.0 4.1e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 T309728_2 - 3.9e-30 104.5 0.0 6.5e-30 103.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.4 T309728_2 - 0.00058 19.0 0.0 0.00084 18.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.4 T309728_2 - 0.0033 17.0 0.0 0.0058 16.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.23 T309728_3 - 1.4e-08 35.1 0.2 1.9e-08 34.6 0.2 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Aldo_ket_red PF00248.19 T036176_1 - 1.4e-55 188.3 0.0 2e-55 187.9 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.19 T036176_3 - 8.5e-33 113.6 0.0 1.2e-29 103.2 0.0 2.1 1 1 1 2 2 2 2 Aldo/keto reductase family SP_C-Propep PF08999.8 T036176_3 - 0.52 10.0 3.6 0.97 9.1 3.6 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide RasGEF_N PF00618.18 T168593_1 - 1.8e-07 31.2 0.0 3.2e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 RasGEF N-terminal motif RasGEF PF00617.17 T168593_2 - 1.5e-52 178.1 0.0 2.1e-52 177.6 0.0 1.2 1 0 0 1 1 1 1 RasGEF domain EpoR_lig-bind PF09067.8 T168593_2 - 1.6e-28 98.8 0.0 3e-28 97.9 0.0 1.5 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding RA PF00788.21 T168593_2 - 2.9e-06 27.7 0.0 6.1e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain fn3 PF00041.19 T168593_2 - 7.9e-06 26.0 0.0 1.7e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain DUF4512 PF14975.4 T162035_2 - 1.9e-14 54.0 1.7 3.9e-14 53.1 1.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4512) 7tm_2 PF00002.22 T007109_1 - 1.1e-62 211.4 12.9 1.6e-62 210.9 12.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) TSP_1 PF00090.17 T007109_1 - 1.7e-38 130.4 67.6 1.1e-11 44.6 8.4 5.1 4 0 0 4 4 4 4 Thrombospondin type 1 domain GAIN PF16489.3 T007109_1 - 2.3e-36 125.1 0.0 3.4e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.19 T007109_1 - 2.1e-12 47.4 4.5 9.2e-12 45.3 4.5 2.3 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_1 PF00001.19 T007109_1 - 0.00099 18.3 0.0 0.0017 17.5 0.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Troponin PF00992.18 T052885_2 - 2.9e-45 153.7 8.9 4e-45 153.3 8.9 1.2 1 0 0 1 1 1 1 Troponin DUF2408 PF10303.7 T052885_2 - 0.0098 16.3 1.8 0.017 15.6 1.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2408) Tup_N PF08581.8 T052885_2 - 0.033 14.4 0.8 0.062 13.5 0.8 1.4 1 0 0 1 1 1 0 Tup N-terminal DUF919 PF06034.9 T052885_2 - 0.056 13.1 0.5 0.13 12.0 0.5 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) C2 PF00168.28 T052885_3 - 1.6e-33 114.9 0.0 5.9e-17 61.7 0.0 2.2 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.22 T052885_3 - 0.22 11.5 0.0 24 4.9 0.0 2.2 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 CYSTM PF12734.5 T290029_2 - 2.1e-08 34.3 9.6 2.1e-08 34.3 9.6 3.7 3 0 0 3 3 3 1 Cysteine-rich TM module stress tolerance C2 PF00168.28 T065163_2 - 1.7e-34 118.0 2.4 6.1e-20 71.3 0.5 3.2 3 0 0 3 3 3 2 C2 domain FYVE_2 PF02318.14 T065163_2 - 1.6e-06 28.2 0.8 4.4e-06 26.8 0.8 1.8 1 0 0 1 1 1 1 FYVE-type zinc finger MSC PF09402.8 T065163_2 - 0.1 12.0 2.3 0.18 11.1 0.3 2.3 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain MCM2_N PF12619.6 T065163_2 - 3.9 7.6 6.9 10 6.3 0.1 2.7 2 0 0 2 2 2 0 Mini-chromosome maintenance protein 2 zf-C4H2 PF10146.7 T156011_2 - 6.8e-05 23.1 0.7 6.8e-05 23.1 0.7 1.9 2 0 0 2 2 2 1 Zinc finger-containing protein UPF0561 PF10573.7 T156011_2 - 0.41 10.6 7.8 1.3 9.0 0.1 3.1 3 0 0 3 3 3 0 Uncharacterised protein family UPF0561 Ras PF00071.20 T335958_1 - 3.1e-16 59.3 0.0 4.3e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T335958_1 - 0.037 14.1 0.0 0.069 13.3 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ArfGap PF01412.16 T335958_2 - 2.7e-36 124.0 0.0 4.6e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.27 T335958_2 - 9.8e-11 42.0 0.0 0.00036 20.9 0.0 2.4 2 0 0 2 2 2 2 PH domain Ank_2 PF12796.5 T335958_2 - 2.3e-06 27.9 0.0 3.9e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T335958_2 - 0.00017 22.0 0.0 0.046 14.2 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 T335958_2 - 0.00024 21.3 0.0 0.24 11.8 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 T335958_2 - 0.01 16.1 0.2 0.049 13.9 0.1 2.0 1 1 1 2 2 2 0 Ankyrin repeats (many copies) PH_6 PF15406.4 T335958_2 - 0.023 14.8 0.1 0.041 14.0 0.1 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain Vinculin PF01044.17 T192568_3 - 9.2e-95 318.6 10.9 2e-94 317.5 11.0 1.4 1 1 0 1 1 1 1 Vinculin family SAWADEE PF16719.3 T192568_3 - 0.18 11.7 0.8 0.38 10.6 0.1 1.8 2 0 0 2 2 2 0 SAWADEE domain CorA PF01544.16 T192568_3 - 0.56 9.3 2.2 0.5 9.5 0.4 1.8 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Smg4_UPF3 PF03467.13 T100016_1 - 8.3e-26 90.9 0.0 1.7e-25 90.0 0.0 1.4 1 0 0 1 1 1 1 Smg-4/UPF3 family Smg4_UPF3 PF03467.13 T100016_2 - 4.6e-19 69.0 0.8 4.6e-19 69.0 0.8 2.4 3 0 0 3 3 3 1 Smg-4/UPF3 family Guanylate_kin PF00625.19 T258513_1 - 7.1e-54 182.1 4.1 9.9e-54 181.6 4.1 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 T258513_3 - 7.6e-62 205.5 8.7 7.5e-20 70.9 0.3 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) L27_1 PF09058.8 T258513_3 - 1.9e-29 101.3 4.3 3.9e-29 100.4 4.3 1.5 1 0 0 1 1 1 1 L27_1 MAGUK_N_PEST PF10608.7 T258513_3 - 9.1e-27 93.8 6.0 2.4e-25 89.2 0.6 2.7 1 1 1 2 2 2 2 Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_assoc PF10600.7 T258513_3 - 3.6e-24 85.2 4.2 1.1e-23 83.7 4.2 1.9 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 T258513_3 - 5e-16 58.7 0.9 0.0003 20.9 0.1 3.6 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.15 T258513_3 - 4.5e-08 32.5 0.0 1e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 T258513_3 - 5.7e-08 32.1 0.1 1.3e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 SH3 domain Guanylate_kin PF00625.19 T258513_3 - 0.00081 19.0 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase SH3_9 PF14604.4 T258513_3 - 0.032 14.0 0.0 0.066 12.9 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain FancD2 PF14631.4 T237843_3 - 0 2611.9 33.8 0 2611.7 33.8 1.0 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease FANCI_S2 PF14676.4 T237843_3 - 1.6e-06 28.3 1.6 8e-06 26.0 0.5 2.9 1 1 1 2 2 2 1 FANCI solenoid 2 Trans_coact PF16805.3 T237843_3 - 0.028 14.4 0.0 0.11 12.4 0.0 2.0 1 0 0 1 1 1 0 Phage late-transcription coactivator MKT1_N PF12247.6 T237843_3 - 0.06 13.6 0.5 0.33 11.2 0.0 2.6 3 0 0 3 3 3 0 Temperature dependent protein affecting M2 dsRNA replication Ldl_recept_b PF00058.15 T269550_3 - 1.4e-41 140.6 5.1 8.2e-10 38.9 0.0 9.0 10 0 0 10 10 10 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 T269550_3 - 2.7e-26 91.4 97.9 2.6e-08 33.9 7.0 7.9 8 0 0 8 8 8 5 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 T269550_3 - 1e-20 73.5 32.0 4.4e-10 39.5 6.0 7.5 7 0 0 7 7 7 3 Calcium-binding EGF domain cEGF PF12662.5 T269550_3 - 9.3e-18 63.7 47.8 5.3e-05 22.9 1.3 7.1 7 0 0 7 7 7 5 Complement Clr-like EGF-like EGF PF00008.25 T269550_3 - 5.7e-15 55.2 86.2 0.00037 20.6 3.2 8.7 8 0 0 8 8 8 7 EGF-like domain DUF5050 PF16472.3 T269550_3 - 5.3e-11 42.2 0.0 7.1e-05 22.0 0.1 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF5050) EGF_3 PF12947.5 T269550_3 - 8.8e-11 41.7 80.2 1.2e-05 25.3 5.5 7.6 7 1 1 8 8 8 4 EGF domain SGL PF08450.10 T269550_3 - 0.00038 20.0 0.2 7.9 5.8 0.0 4.3 3 2 1 4 4 4 2 SMP-30/Gluconolaconase/LRE-like region Peptidase_C1 PF00112.21 T061722_2 - 1.7e-65 221.0 0.8 1.5e-52 178.8 0.0 2.2 2 0 0 2 2 2 2 Papain family cysteine protease Inhibitor_I29 PF08246.10 T061722_2 - 2.1e-07 31.1 0.6 3.4e-07 30.4 0.6 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 T061722_2 - 0.0039 15.9 0.8 0.071 11.7 0.1 2.1 2 0 0 2 2 2 2 Peptidase C1-like family APG6 PF04111.10 T147964_2 - 6.7e-83 278.5 12.4 9.1e-83 278.1 12.4 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 BH3 PF15285.4 T147964_2 - 8.5e-17 60.4 0.2 1.5e-16 59.6 0.2 1.4 1 0 0 1 1 1 1 Beclin-1 BH3 domain, Bcl-2-interacting MT PF12777.5 T147964_2 - 0.017 14.0 8.6 0.026 13.4 8.6 1.1 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor HAUS-augmin3 PF14932.4 T147964_2 - 0.025 13.9 17.8 0.039 13.3 17.8 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 EzrA PF06160.10 T147964_2 - 0.3 9.1 19.3 0.41 8.6 19.3 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA ERM PF00769.17 T147964_2 - 0.34 10.6 22.5 0.58 9.8 22.5 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Suppressor_APC PF11414.6 T147964_2 - 0.41 10.6 11.9 0.98 9.4 11.9 1.6 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein Exonuc_VII_L PF02601.13 T147964_2 - 0.43 10.0 7.1 0.62 9.4 7.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FTA4 PF13093.4 T147964_2 - 1.4 8.6 10.7 2.3 7.9 10.7 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Spc7 PF08317.9 T147964_2 - 3 6.5 23.5 4.6 5.9 23.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein IFT57 PF10498.7 T147964_2 - 3.1 6.6 17.9 4.9 5.9 17.9 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 GAS PF13851.4 T147964_2 - 3.6 6.8 27.2 3 7.0 7.8 1.8 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF342 PF03961.11 T147964_2 - 7.2 5.0 17.8 4.3 5.7 11.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Ima1_N PF09779.7 T147964_2 - 8.5 7.1 12.5 8.5 7.1 2.3 2.6 1 1 1 2 2 2 0 Ima1 N-terminal domain DUF4200 PF13863.4 T147964_2 - 9.7 6.5 28.1 2.2 8.6 21.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) APG6 PF04111.10 T147964_3 - 2.3e-15 56.7 0.1 3.2e-15 56.2 0.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 Thioredox_DsbH PF03190.13 T150523_3 - 1e-72 243.3 0.0 1.6e-72 242.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.4 T150523_3 - 5.5e-11 42.4 0.0 1.1e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like GlcNAc_2-epim PF07221.9 T150523_3 - 1.7e-06 27.4 0.5 0.00052 19.2 0.2 2.4 2 0 0 2 2 2 2 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Thioredoxin_2 PF13098.4 T150523_3 - 0.026 14.9 0.0 0.05 13.9 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain IBN_N PF03810.17 T054631_3 - 1.6e-21 75.9 0.0 1.4e-20 72.8 0.0 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.8 T054631_3 - 2.2e-08 33.2 1.5 2.2e-08 33.2 1.5 1.9 2 0 0 2 2 2 1 Cse1 DUF3730 PF12530.6 T054631_3 - 0.05 13.1 1.9 0.046 13.2 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3730) Xpo1 PF08389.10 T054631_3 - 0.053 13.4 9.0 0.009 15.9 1.6 3.3 4 1 0 4 4 4 0 Exportin 1-like protein PID PF00640.21 T263874_3 - 1.7e-49 167.3 0.0 5.3e-37 126.8 0.0 2.3 2 0 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.24 T263874_3 - 5.6e-06 26.1 2.6 1.3e-05 24.9 2.6 1.7 1 0 0 1 1 1 1 WW domain PTB PF08416.11 T263874_3 - 2e-05 24.6 0.0 0.0021 18.1 0.0 2.4 2 0 0 2 2 2 2 Phosphotyrosine-binding domain zf-H2C2_2 PF13465.4 T039375_3 - 1.6e-08 34.5 20.2 0.00015 21.9 4.0 4.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 T039375_3 - 0.00051 20.5 2.3 0.00051 20.5 2.3 6.4 6 0 0 6 6 6 2 C2H2-type zinc finger zf-C2H2 PF00096.24 T039375_3 - 0.0018 18.5 2.8 0.0018 18.5 2.8 5.7 6 0 0 6 6 6 2 Zinc finger, C2H2 type zf-met PF12874.5 T039375_3 - 0.089 13.1 0.1 0.089 13.1 0.1 3.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Thioredoxin PF00085.18 T115680_3 - 2e-67 223.5 0.0 3.2e-33 113.6 0.0 3.0 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.4 T115680_3 - 3.4e-35 121.6 1.2 1.9e-27 96.3 2.5 2.8 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.4 T115680_3 - 2.2e-08 34.4 0.1 0.0013 19.0 0.0 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.4 T115680_3 - 5.5e-07 29.7 0.2 0.0063 16.7 0.0 3.7 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.4 T115680_3 - 1.5e-05 24.9 0.0 0.048 13.7 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.19 T115680_3 - 0.00024 20.9 0.0 0.4 10.5 0.0 2.9 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_4 PF13462.4 T115680_3 - 0.0054 16.8 0.0 2.1 8.3 0.0 3.3 2 1 1 3 3 3 1 Thioredoxin Thioredoxin_3 PF13192.4 T115680_3 - 0.12 12.3 0.0 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin domain SVA PF05326.9 T334816_3 - 1.4e-53 180.0 0.4 1.7e-53 179.7 0.4 1.1 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) TauD PF02668.14 T056304_2 - 1.2e-42 146.4 0.0 1.7e-42 146.0 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.10 T056304_2 - 1.5e-13 51.0 0.8 1.8e-11 44.4 0.1 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF971) Transposase_22 PF02994.12 T056304_2 - 0.00016 20.6 0.3 0.023 13.4 0.0 2.2 2 0 0 2 2 2 2 L1 transposable element CsiD PF08943.8 T056304_2 - 0.00078 18.5 0.0 0.0016 17.5 0.0 1.4 1 0 0 1 1 1 1 CsiD zf-C3HC4_4 PF15227.4 T053813_2 - 1.9e-10 40.6 7.6 8.4e-10 38.5 7.6 2.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 T053813_2 - 8e-10 38.4 7.2 8e-10 38.4 7.2 2.4 2 0 0 2 2 1 1 RING-type zinc-finger SPRY PF00622.26 T053813_2 - 4.7e-09 36.3 0.2 8.6e-09 35.4 0.2 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 T053813_2 - 3.3e-08 33.1 5.5 3.3e-08 33.1 5.5 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 T053813_2 - 3.4e-08 33.4 2.1 3.4e-08 33.4 2.1 3.8 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_2 PF13923.4 T053813_2 - 1.4e-07 31.1 5.8 7.1e-07 28.8 6.0 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T053813_2 - 1.1e-05 25.2 5.3 1.1e-05 25.2 5.3 3.0 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 T053813_2 - 1.2e-05 25.3 6.5 1.2e-05 25.3 6.5 3.1 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 T053813_2 - 5.4e-05 22.8 4.4 5.4e-05 22.8 4.4 2.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 T053813_2 - 0.00023 20.6 0.1 0.00051 19.5 0.1 1.6 1 0 0 1 1 1 1 SPRY-associated domain Fib_alpha PF08702.8 T053813_2 - 0.45 10.6 11.1 0.87 9.6 11.1 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Prok-RING_4 PF14447.4 T053813_2 - 3.7 7.4 14.1 0.17 11.6 5.4 2.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.4 T053813_3 - 1.4e-10 41.0 7.0 5.5e-10 39.1 7.0 2.2 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 T053813_3 - 3.3e-10 39.7 3.8 9.8e-10 38.2 3.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger SPRY PF00622.26 T053813_3 - 4.9e-09 36.2 0.2 9.7e-09 35.3 0.2 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 T053813_3 - 1.7e-08 34.0 5.9 7.9e-08 31.9 5.9 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 T053813_3 - 4.5e-07 29.8 4.9 4.5e-07 29.8 4.9 2.8 2 0 0 2 2 2 1 B-box zinc finger zf-C3HC4_2 PF13923.4 T053813_3 - 5.8e-06 25.9 6.1 2.6e-05 23.8 6.1 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 T053813_3 - 6.6e-06 25.8 3.8 6e-05 22.7 3.8 2.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T053813_3 - 3.7e-05 23.8 5.2 3.7e-05 23.8 5.2 3.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 T053813_3 - 0.00024 20.9 4.2 0.00024 20.9 4.2 3.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_10 PF16685.3 T053813_3 - 0.00096 19.1 3.2 0.00096 19.1 3.2 2.4 1 1 1 2 2 2 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 T053813_3 - 1 9.2 8.8 1.2 8.9 6.2 2.6 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 Copine PF07002.14 T217003_2 - 9e-85 283.4 0.0 1.6e-84 282.6 0.0 1.4 1 0 0 1 1 1 1 Copine C2 PF00168.28 T217003_2 - 5.7e-26 90.7 0.0 6.7e-13 48.7 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 T217003_2 - 4.8e-06 26.7 0.0 7.9e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus Shugoshin_N PF07558.9 T238989_1 - 3.7e-11 42.6 2.2 9.3e-11 41.3 2.2 1.8 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.9 T238989_1 - 7.9e-10 38.2 1.3 2.2e-09 36.8 1.3 1.8 1 0 0 1 1 1 1 Shugoshin C terminus Menin PF05053.11 T238989_1 - 0.78 7.9 12.5 1.1 7.4 12.5 1.1 1 0 0 1 1 1 0 Menin WH1 PF00568.21 T170790_1 - 1.8e-35 121.1 0.2 2.7e-35 120.5 0.2 1.3 1 0 0 1 1 1 1 WH1 domain DUF4407 PF14362.4 T170790_1 - 0.034 13.4 18.4 0.068 12.4 18.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec66 PF09802.7 T170790_1 - 0.086 12.3 3.2 0.18 11.3 3.2 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 AAA_13 PF13166.4 T170790_1 - 0.26 9.8 12.3 0.51 8.8 12.3 1.4 1 1 0 1 1 1 0 AAA domain DUF812 PF05667.9 T170790_1 - 0.5 9.1 11.9 0.84 8.3 11.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) ATG16 PF08614.9 T170790_1 - 2.3 8.2 29.5 28 4.7 17.1 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) GrpE PF01025.17 T170790_1 - 2.8 7.5 15.9 5.2 6.6 3.1 2.4 2 0 0 2 2 2 0 GrpE Herpes_UL6 PF01763.14 T170790_1 - 4.3 5.6 4.9 3.1 6.1 3.4 1.4 1 1 0 1 1 1 0 Herpesvirus UL6 like DUF4200 PF13863.4 T170790_1 - 5.6 7.2 19.6 1.1 9.5 9.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) MerR-DNA-bind PF09278.9 T170790_1 - 8.4 6.9 19.3 0.086 13.3 4.8 2.9 2 1 0 2 2 2 0 MerR, DNA binding BST2 PF16716.3 T170790_1 - 8.7 6.9 18.4 11 6.6 3.8 2.8 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 RRM_1 PF00076.20 T013056_3 - 9.6e-06 25.2 0.0 1.5e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NACHT PF05729.10 T180554_1 - 2e-55 187.1 0.1 7.6e-54 181.9 0.0 2.3 2 0 0 2 2 2 1 NACHT domain LRR_6 PF13516.4 T180554_1 - 1.3e-18 65.3 30.4 0.0007 19.3 1.0 8.1 8 0 0 8 8 8 6 Leucine Rich repeat FISNA PF14484.4 T180554_1 - 1.6e-11 44.2 0.0 3.4e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 Fish-specific NACHT associated domain LRR_4 PF12799.5 T180554_1 - 0.00012 22.2 22.9 0.33 11.3 0.2 6.7 4 2 1 6 6 6 3 Leucine Rich repeats (2 copies) NB-ARC PF00931.20 T180554_1 - 0.16 10.8 0.0 0.27 10.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain 14-3-3 PF00244.18 T348543_2 - 5.6e-109 362.7 7.5 7e-109 362.4 7.5 1.1 1 0 0 1 1 1 1 14-3-3 protein HLH PF00010.24 T048488_3 - 1.6e-10 40.6 1.8 1.7e-09 37.3 1.2 2.8 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain KASH_CCD PF14662.4 T048488_3 - 0.058 13.1 4.7 0.11 12.2 4.7 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH BRE1 PF08647.9 T048488_3 - 0.2 11.6 2.4 0.47 10.4 2.4 1.6 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase CCDC106 PF15794.3 T048488_3 - 8.4 5.9 10.8 0.15 11.6 3.0 1.8 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Lipase PF00151.17 T162055_1 - 3.9e-106 355.0 0.0 7e-106 354.2 0.0 1.3 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 T162055_1 - 6e-25 88.0 0.1 9.8e-25 87.3 0.1 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain InaF-motif PF15018.4 T162055_1 - 0.00093 18.9 0.9 0.0031 17.2 0.9 1.9 1 0 0 1 1 1 1 TRP-interacting helix Abhydrolase_6 PF12697.5 T162055_1 - 0.0031 18.0 1.3 0.0061 17.1 1.3 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 T162055_1 - 0.063 12.8 0.2 0.097 12.2 0.2 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Forkhead PF00250.16 T144550_1 - 1.7e-31 108.2 0.2 2.8e-31 107.5 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain EST1_DNA_bind PF10373.7 T026357_2 - 2.6e-55 187.8 5.2 2.6e-55 187.8 5.2 1.8 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.7 T026357_2 - 2.1e-27 96.3 0.3 7.1e-27 94.6 0.3 2.0 1 0 0 1 1 1 1 Telomerase activating protein Est1 zf-AD PF07776.13 T026357_2 - 0.01 15.9 0.6 0.04 14.0 0.6 2.1 1 1 0 1 1 1 0 Zinc-finger associated domain (zf-AD) TPR_2 PF07719.15 T026357_2 - 0.13 12.4 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.4 T026357_2 - 0.15 12.4 0.2 1.1 9.7 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4486 PF14858.4 T084549_1 - 7.8e-279 925.6 11.1 7.8e-279 925.6 11.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4486) LNS2 PF08235.11 T084549_1 - 0.031 13.6 0.1 0.35 10.1 0.0 2.4 2 0 0 2 2 2 0 LNS2 (Lipin/Ned1/Smp2) CALM_bind PF16025.3 T128262_2 - 1.8e-25 89.0 17.0 1.5e-19 70.1 1.2 3.2 3 0 0 3 3 3 2 Calcium-dependent calmodulin binding UFC1 PF08694.9 T023723_1 - 4.9e-84 279.4 0.1 8.9e-84 278.6 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UCH PF00443.27 T023723_3 - 2.4e-60 204.1 0.0 4.3e-60 203.2 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Amino_oxidase PF01593.22 T023723_3 - 3e-48 165.1 0.5 2.8e-35 122.3 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase UCH_1 PF13423.4 T023723_3 - 2.6e-17 63.3 0.0 4.3e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase NAD_binding_8 PF13450.4 T023723_3 - 1e-10 41.6 1.2 2.6e-10 40.3 0.2 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 T023723_3 - 4.1e-06 26.5 0.7 0.00014 21.4 0.5 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.15 T023723_3 - 0.01 14.9 0.1 0.017 14.3 0.1 1.2 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.5 T023723_3 - 0.026 13.8 0.1 0.039 13.2 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 T023723_3 - 0.065 12.2 0.1 0.1 11.6 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.12 T023723_3 - 0.1 11.7 0.0 0.31 10.1 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Ldh_1_N PF00056.21 T055722_1 - 2.8e-96 319.0 5.7 5.9e-49 165.6 0.7 2.2 2 0 0 2 2 2 2 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 T055722_1 - 8.4e-51 172.1 0.0 1.2e-25 90.3 0.0 2.2 2 0 0 2 2 2 2 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 T055722_1 - 0.00056 19.4 2.7 0.32 10.4 0.0 2.6 3 0 0 3 3 3 2 Family 4 glycosyl hydrolase Pyr_redox_2 PF07992.12 T055722_1 - 0.00067 18.8 0.0 0.48 9.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Ldh_1_N PF00056.21 T055722_3 - 6.7e-46 155.8 0.2 9.2e-46 155.3 0.2 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 T055722_3 - 1.6e-21 76.8 0.0 2.4e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain UDPG_MGDP_dh_N PF03721.12 T055722_3 - 0.11 11.9 0.2 0.16 11.4 0.2 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Carb_anhydrase PF00194.19 T347104_2 - 1e-89 300.3 0.0 1.4e-89 299.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Ig_3 PF13927.4 T355281_2 - 2e-11 44.2 0.2 0.00039 20.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 T355281_2 - 5.3e-09 35.9 0.5 1.3e-08 34.6 0.5 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 T355281_2 - 5.9e-08 32.5 0.4 0.01 15.7 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 T355281_2 - 1.4e-07 31.5 0.1 0.00071 19.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 T355281_2 - 9.1e-07 28.9 0.3 2.1e-06 27.7 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T355281_2 - 8.7e-06 25.9 0.1 0.03 14.6 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.13 T355281_2 - 0.00032 21.0 0.6 0.00083 19.7 0.4 1.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Lectin_C PF00059.19 T073834_1 - 0.00043 20.9 0.0 0.00087 19.9 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 T073834_2 - 0.036 13.6 0.1 0.061 12.8 0.1 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.19 T073834_3 - 1e-16 61.4 1.4 2.2e-16 60.4 1.4 1.6 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 T073834_3 - 0.00049 19.7 4.4 0.0011 18.5 4.4 1.5 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 T073834_3 - 0.013 14.6 0.3 0.023 13.8 0.3 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein VKOR PF07884.12 T130683_2 - 6.6e-25 87.6 12.8 1.1e-24 86.8 12.8 1.4 1 0 0 1 1 1 1 Vitamin K epoxide reductase family Trypsin PF00089.24 T130683_3 - 7.3e-68 228.5 0.0 7.8e-43 146.7 0.1 2.2 2 0 0 2 2 2 2 Trypsin DUF1986 PF09342.9 T130683_3 - 1.5e-09 38.1 0.0 3.2e-05 24.2 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 T130683_3 - 1.1e-08 36.0 0.0 9.8e-06 26.4 0.0 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain TIR PF01582.18 T257004_1 - 4.4e-39 134.0 0.1 7.3e-39 133.2 0.1 1.4 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.4 T257004_1 - 2.1e-13 50.6 2.3 7.5e-07 29.5 0.2 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 T257004_1 - 1.4e-09 38.0 1.3 0.00011 22.4 0.2 3.6 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 T257004_1 - 9.6e-07 28.8 4.4 0.073 13.1 0.1 4.2 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.14 T257004_1 - 2.8e-06 27.1 0.1 1.3 9.0 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain TIR_2 PF13676.4 T257004_1 - 0.015 15.4 0.0 0.028 14.6 0.0 1.4 1 0 0 1 1 1 0 TIR domain SUZ PF12752.5 T004009_1 - 5.9e-13 49.2 0.1 1.8e-12 47.7 0.1 1.9 1 0 0 1 1 1 1 SUZ domain TPR_12 PF13424.4 T260771_1 - 2.5e-19 69.2 45.4 5e-05 23.4 4.2 9.1 8 2 3 11 11 11 6 Tetratricopeptide repeat TPR_8 PF13181.4 T260771_1 - 8.4e-10 38.0 13.4 1.9 8.8 0.0 9.5 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_1 PF00515.26 T260771_1 - 4.3e-08 32.5 7.2 0.71 9.7 0.3 6.9 5 0 0 5 5 5 3 Tetratricopeptide repeat SH3_1 PF00018.26 T260771_1 - 3.7e-05 23.1 0.0 7.9e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain TPR_7 PF13176.4 T260771_1 - 0.00012 21.7 27.7 0.37 10.8 0.4 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_2 PF07719.15 T260771_1 - 0.00019 21.2 28.1 0.18 11.9 0.1 8.8 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_10 PF13374.4 T260771_1 - 0.0054 16.4 16.5 7.6 6.4 0.3 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat SH3_2 PF07653.15 T260771_1 - 0.019 14.5 0.0 0.046 13.3 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain TPR_19 PF14559.4 T260771_1 - 5 7.6 11.4 2.1 8.8 0.4 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat WD40 PF00400.30 T023451_1 - 2e-15 56.7 1.8 7.5e-06 26.5 0.5 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T023451_1 - 0.0026 17.9 0.1 5.7 7.2 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1510 PF07423.9 T023451_1 - 4.8 6.4 12.0 7.6 5.8 12.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4661 PF15576.4 T023451_1 - 8.3 6.1 6.3 14 5.3 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) WD40 PF00400.30 T023451_2 - 0.083 13.7 0.0 0.34 11.7 0.0 2.0 1 0 0 1 1 1 0 WD domain, G-beta repeat PLDc_3 PF13918.4 T175523_1 - 2.4e-38 131.4 0.0 4.2e-38 130.6 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.4 T175523_1 - 1.6e-27 95.8 0.0 1.3e-17 63.8 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.20 T175523_1 - 4.4e-11 42.4 5.6 1.7e-08 34.2 0.5 3.0 3 0 0 3 3 3 2 Phospholipase D Active site motif WD40 PF00400.30 T085810_3 - 3.8e-09 36.9 10.3 0.016 15.9 0.1 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T085810_3 - 0.0017 18.5 0.1 0.093 12.9 0.0 2.7 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain KRTDAP PF15200.4 T173694_2 - 0.054 13.1 7.2 0.82 9.4 1.9 2.3 1 1 1 2 2 2 0 Keratinocyte differentiation-associated KRTDAP PF15200.4 T173694_3 - 3.6e-38 129.1 0.2 5.6e-38 128.5 0.2 1.3 1 0 0 1 1 1 1 Keratinocyte differentiation-associated Ras PF00071.20 T210549_3 - 4.5e-40 136.8 0.1 6.8e-40 136.2 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T210549_3 - 4.6e-16 59.0 0.0 7.7e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T210549_3 - 7.2e-08 32.0 0.1 1.2e-07 31.2 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Pkinase PF00069.23 T072079_3 - 6.8e-53 179.6 0.1 9.7e-53 179.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain RAD51_interact PF15696.3 T072079_3 - 9.6e-19 67.1 7.6 2.8e-18 65.6 7.6 1.9 1 0 0 1 1 1 1 RAD51 interacting motif Pkinase_Tyr PF07714.15 T072079_3 - 3.5e-18 65.7 0.2 5.5e-18 65.1 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Acyl_transf_1 PF00698.19 T156828_1 - 1.3e-115 386.2 0.0 1.9e-115 385.6 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.24 T156828_1 - 1.1e-71 241.3 0.0 1.9e-71 240.5 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thioesterase PF00975.18 T156828_1 - 1.7e-64 218.0 0.1 3.1e-64 217.1 0.1 1.5 1 0 0 1 1 1 1 Thioesterase domain KR PF08659.8 T156828_1 - 1.2e-46 158.8 0.0 2.5e-46 157.7 0.0 1.6 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.20 T156828_1 - 3.9e-37 126.7 0.0 1.1e-36 125.2 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.3 T156828_1 - 2.3e-35 121.3 0.0 4.5e-35 120.4 0.0 1.5 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.24 T156828_1 - 1.6e-18 66.7 0.0 2.8e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PS-DH PF14765.4 T156828_1 - 6.7e-18 64.8 0.1 1.3e-17 63.8 0.1 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase ADH_zinc_N_2 PF13602.4 T156828_1 - 7.4e-15 56.0 0.0 1.6e-14 54.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.23 T156828_1 - 2e-09 37.5 1.9 3.6e-09 36.7 1.9 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_12 PF08242.10 T156828_1 - 3.1e-07 30.9 0.0 5.8e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T156828_1 - 7.7e-06 25.6 0.0 2.9e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.23 T156828_1 - 8e-05 22.1 0.0 0.00021 20.7 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase Thiolase_N PF00108.21 T156828_1 - 0.00058 19.2 0.0 0.00095 18.5 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.10 T156828_1 - 0.0013 19.2 0.0 0.0034 17.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 T156828_1 - 0.0034 17.2 0.0 0.0073 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain YjeF_N PF03853.13 T156828_1 - 0.085 12.6 0.1 0.38 10.5 0.0 1.9 2 0 0 2 2 2 0 YjeF-related protein N-terminus GpcrRhopsn4 PF10192.7 T176259_2 - 8.5e-78 261.2 17.0 8.5e-78 261.2 17.0 1.6 2 0 0 2 2 2 1 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.11 T176259_2 - 0.13 11.3 9.0 0.2 10.7 9.0 1.2 1 0 0 1 1 1 0 Lung seven transmembrane receptor Kelch_3 PF13415.4 T176259_3 - 6.3e-40 134.6 38.4 5.5e-07 29.6 0.2 13.4 11 1 0 11 11 11 8 Galactose oxidase, central domain Kelch_4 PF13418.4 T176259_3 - 1.1e-39 134.0 22.2 1.4e-09 37.6 0.1 10.3 10 1 1 11 11 11 7 Galactose oxidase, central domain Kelch_6 PF13964.4 T176259_3 - 9.5e-27 92.2 16.8 0.00015 21.8 0.0 11.9 10 2 2 12 12 12 6 Kelch motif Kelch_5 PF13854.4 T176259_3 - 3.1e-25 87.5 27.7 0.00046 20.0 0.0 10.8 11 0 0 11 11 11 8 Kelch motif Kelch_1 PF01344.23 T176259_3 - 3.2e-22 77.7 2.5 0.17 11.4 0.0 10.8 10 0 0 10 10 10 6 Kelch motif CUB PF00431.18 T176259_3 - 6.5e-15 55.3 0.0 4.3e-14 52.7 0.0 2.2 2 0 0 2 2 2 1 CUB domain Kelch_2 PF07646.13 T176259_3 - 4.6e-09 35.8 21.6 4 7.4 0.1 11.0 12 0 0 12 12 11 3 Kelch motif Laminin_EGF PF00053.22 T176259_3 - 1.2e-08 34.9 14.7 1.2e-08 34.9 14.7 16.9 13 5 4 17 17 9 6 Laminin EGF domain EGF_3 PF12947.5 T176259_3 - 1.3e-07 31.5 4.8 1.3e-07 31.5 4.8 9.5 10 0 0 10 10 4 2 EGF domain PSI PF01437.23 T176259_3 - 1.6e-07 31.6 27.0 7.8e-07 29.4 6.5 18.1 15 4 1 16 16 12 7 Plexin repeat EGF_CA PF07645.13 T176259_3 - 2.6e-07 30.6 6.3 2.6e-07 30.6 6.3 12.6 10 4 5 15 15 6 2 Calcium-binding EGF domain PSI_integrin PF17205.1 T176259_3 - 3.1e-05 23.6 18.9 0.00028 20.5 6.7 13.9 14 0 0 14 14 10 4 Integrin plexin domain EGF_2 PF07974.11 T176259_3 - 0.00085 19.5 8.5 0.00085 19.5 8.5 16.5 19 0 0 19 19 11 3 EGF-like domain Filament PF00038.19 T078986_2 - 1.1e-99 333.9 34.3 3.2e-93 312.6 28.7 3.1 3 0 0 3 3 3 2 Intermediate filament protein Keratin_2_head PF16208.3 T078986_2 - 3.2e-07 30.5 0.0 3.2e-07 30.5 0.0 2.1 2 0 0 2 2 2 1 Keratin type II head TPR_MLP1_2 PF07926.10 T078986_2 - 4.8e-05 23.3 19.9 0.0023 17.9 0.2 3.0 2 1 1 3 3 3 2 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.7 T078986_2 - 0.0039 17.1 7.3 0.0039 17.1 7.3 2.9 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.6 T078986_2 - 0.0081 16.1 4.2 0.0081 16.1 4.2 3.3 2 1 1 3 3 3 1 Afadin- and alpha -actinin-Binding Alanine_zipper PF11839.6 T078986_2 - 0.014 15.5 1.6 0.043 14.0 1.6 1.8 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Spc7 PF08317.9 T078986_2 - 0.018 13.8 27.2 0.53 9.0 7.7 2.8 1 1 1 2 2 2 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 T078986_2 - 0.063 12.5 4.4 0.49 9.6 0.3 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein JIP_LZII PF16471.3 T078986_2 - 0.078 13.0 13.6 8.8 6.4 0.8 4.6 3 1 1 4 4 4 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.10 T078986_2 - 0.19 11.6 10.3 0.77 9.6 0.9 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 T078986_2 - 0.23 11.4 8.0 0.15 11.9 0.6 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rootletin PF15035.4 T078986_2 - 0.3 11.0 15.7 1 9.3 4.4 2.7 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion She9_MDM33 PF05546.9 T078986_2 - 0.31 10.7 4.3 4.3 7.0 0.2 2.4 2 0 0 2 2 2 0 She9 / Mdm33 family FPP PF05911.9 T078986_2 - 0.84 7.7 22.3 1.2 7.1 17.9 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil TMF_TATA_bd PF12325.6 T078986_2 - 0.89 9.7 18.8 3.1 7.9 6.1 3.5 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF5082 PF16888.3 T078986_2 - 0.96 9.7 14.8 2.6 8.3 1.3 3.1 1 1 0 2 2 2 0 Domain of unknown function (DUF5082) DUF4164 PF13747.4 T078986_2 - 2.4 8.4 14.2 3.1 8.0 0.3 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) Fib_alpha PF08702.8 T078986_2 - 3.3 7.8 13.7 13 5.9 1.2 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Jnk-SapK_ap_N PF09744.7 T078986_2 - 3.9 7.6 19.0 0.8 9.8 2.4 2.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF342 PF03961.11 T078986_2 - 4.2 5.7 14.0 0.45 8.9 4.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF342) DUF972 PF06156.11 T078986_2 - 7.3 7.2 14.6 7 7.2 0.8 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF972) TMPIT PF07851.11 T078986_2 - 7.9 5.5 9.6 0.78 8.8 2.7 2.2 1 1 1 2 2 2 0 TMPIT-like protein Filament PF00038.19 T078986_3 - 9.9e-95 317.6 29.8 1.4e-91 307.3 27.9 2.2 2 0 0 2 2 2 2 Intermediate filament protein CENP-F_leu_zip PF10473.7 T078986_3 - 0.00024 21.0 4.8 0.00024 21.0 4.8 3.3 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.4 T078986_3 - 0.008 14.8 10.6 0.011 14.2 10.6 1.2 1 0 0 1 1 1 1 AAA domain TPR_MLP1_2 PF07926.10 T078986_3 - 0.016 15.2 15.1 0.078 12.9 0.2 3.0 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 T078986_3 - 0.028 13.2 23.6 0.031 13.0 5.2 2.8 1 1 2 3 3 3 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 T078986_3 - 0.062 12.5 3.0 0.78 8.9 0.2 2.2 1 1 0 2 2 2 0 Reovirus sigma C capsid protein Alanine_zipper PF11839.6 T078986_3 - 0.11 12.7 1.7 0.3 11.3 1.7 1.7 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein ADIP PF11559.6 T078986_3 - 0.23 11.4 13.0 0.38 10.7 5.1 2.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DMPK_coil PF08826.8 T078986_3 - 0.36 10.9 5.9 1.4 8.9 0.9 4.0 4 0 0 4 4 3 0 DMPK coiled coil domain like DUF5082 PF16888.3 T078986_3 - 0.81 9.9 17.1 0.27 11.4 0.5 4.1 2 1 2 5 5 5 0 Domain of unknown function (DUF5082) ATG16 PF08614.9 T078986_3 - 1.5 8.8 20.4 0.48 10.4 9.9 3.1 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.10 T078986_3 - 1.6 8.6 10.7 0.21 11.5 1.5 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.9 T078986_3 - 1.8 9.1 4.0 1.2 9.6 0.8 2.4 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Baculo_PEP_C PF04513.10 T078986_3 - 2.8 7.8 9.7 0.8 9.6 1.6 3.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Golgin_A5 PF09787.7 T078986_3 - 5.8 6.2 19.3 1.6 8.0 8.9 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 KfrA_N PF11740.6 T078986_3 - 6.6 7.3 8.9 0.16 12.5 2.0 1.9 2 0 0 2 2 1 0 Plasmid replication region DNA-binding N-term CLZ PF16526.3 T078986_3 - 7.3 6.9 7.5 3 8.1 1.2 3.1 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels IncA PF04156.12 T078986_3 - 8.4 6.0 22.9 0.068 12.8 7.8 2.9 1 1 0 2 2 2 0 IncA protein Ank_2 PF12796.5 T042553_1 - 1.8e-142 464.1 48.6 4.6e-17 62.3 0.1 11.6 2 2 9 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.28 T042553_1 - 3.4e-129 416.1 66.6 1.3e-06 28.4 0.1 23.3 21 1 2 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 T042553_1 - 2.5e-117 381.7 53.1 8.2e-11 42.1 0.4 16.8 6 3 14 20 20 20 19 Ankyrin repeats (many copies) Ank_5 PF13857.4 T042553_1 - 4.4e-110 357.6 44.1 4.7e-11 42.6 0.0 16.0 4 4 15 19 19 19 19 Ankyrin repeats (many copies) Ank_3 PF13606.4 T042553_1 - 2e-103 325.6 36.6 0.00012 22.0 0.0 24.1 24 0 0 24 24 24 21 Ankyrin repeat ZU5 PF00791.18 T042553_1 - 2e-32 111.2 0.8 8.2e-27 93.3 0.0 2.5 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 T042553_1 - 5.8e-21 74.3 0.0 1.1e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 Death domain CABIT PF12736.5 T006472_2 - 2.2e-58 197.7 0.7 4.1e-41 141.0 0.0 2.6 2 1 0 2 2 2 2 Cell-cycle sustaining, positive selection, BSP_II PF05432.9 T201865_2 - 0.017 14.7 5.7 0.025 14.2 5.7 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Methyltransf_34 PF11312.6 T201865_2 - 0.02 14.0 0.3 0.029 13.5 0.3 1.1 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase CENP-B_dimeris PF09026.8 T201865_2 - 2.8 8.2 7.7 4.8 7.5 7.7 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RNA_pol_3_Rpc31 PF11705.6 T201865_2 - 3.8 7.5 9.6 7.4 6.6 9.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.10 T201865_2 - 4.8 5.1 5.8 6.9 4.6 5.8 1.1 1 0 0 1 1 1 0 Nop14-like family RRM_1 PF00076.20 T201865_3 - 4.9e-31 106.2 0.0 2e-15 56.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nha1_C PF08619.8 T201865_3 - 0.022 13.8 4.2 0.034 13.2 4.2 1.3 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus TT_ORF1 PF02956.12 T201865_3 - 0.027 13.0 14.4 0.056 12.0 14.4 1.5 1 0 0 1 1 1 0 TT viral orf 1 Rrn6 PF10214.7 T201865_3 - 0.98 7.6 9.7 1.7 6.8 9.7 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Laminin_N PF00055.15 T141597_2 - 4.1e-87 291.5 0.0 4.1e-87 291.5 0.0 2.4 3 1 0 3 3 3 1 Laminin N-terminal (Domain VI) NTR PF01759.19 T141597_2 - 5.8e-31 106.3 0.4 9.3e-31 105.7 0.4 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Laminin_EGF PF00053.22 T141597_2 - 1.9e-26 91.8 54.7 9.1e-10 38.4 14.3 4.1 3 0 0 3 3 3 3 Laminin EGF domain FAM198 PF15051.4 T273570_1 - 1.3e-155 517.1 0.0 1.6e-155 516.8 0.0 1.1 1 0 0 1 1 1 1 FAM198 protein PapD-like PF14874.4 T018247_1 - 3e-13 49.7 0.0 5.7e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Flagellar-associated PapD-like PQ-loop PF04193.12 T139754_1 - 1.3e-36 124.0 17.7 3.9e-19 68.0 6.5 2.5 2 0 0 2 2 2 2 PQ loop repeat TPPK_C PF12555.6 T139754_1 - 1.2 9.1 4.0 2.9 7.9 4.0 1.6 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal Crystallin PF00525.16 T139754_3 - 0.024 14.7 0.2 0.06 13.4 0.2 1.6 1 0 0 1 1 1 0 Alpha crystallin A chain, N terminal UPAR_LY6 PF00021.19 T176615_3 - 5.2e-17 62.2 35.9 7e-12 45.8 6.7 3.7 3 0 0 3 3 3 3 u-PAR/Ly-6 domain Tropomodulin PF03250.12 T020779_1 - 1.5e-08 34.6 4.4 2.3e-08 34.1 4.4 1.2 1 0 0 1 1 1 1 Tropomodulin YL1 PF05764.11 T020779_3 - 3.3e-52 177.9 14.7 4.8e-52 177.4 14.7 1.3 1 0 0 1 1 1 1 YL1 nuclear protein Tropomodulin PF03250.12 T020779_3 - 5.2e-37 126.9 0.3 9.6e-37 126.0 0.3 1.4 1 0 0 1 1 1 1 Tropomodulin YL1_C PF08265.9 T020779_3 - 1e-11 44.2 0.6 1.8e-11 43.4 0.6 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DER1 PF04511.13 T230750_2 - 1.2e-68 230.6 7.1 1.5e-68 230.3 7.1 1.1 1 0 0 1 1 1 1 Der1-like family Oleosin PF01277.15 T230750_2 - 0.025 14.2 0.3 0.025 14.2 0.3 2.0 2 0 0 2 2 2 0 Oleosin C2 PF00168.28 T251540_1 - 1.4e-34 118.3 0.5 6.1e-18 64.9 0.0 3.0 2 1 0 2 2 2 2 C2 domain RasGAP PF00616.17 T251540_1 - 3.2e-26 92.2 0.2 6.2e-16 58.6 0.3 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase PH PF00169.27 T251540_1 - 2e-14 53.8 0.4 5.4e-14 52.4 0.4 1.8 1 0 0 1 1 1 1 PH domain BTK PF00779.17 T251540_1 - 1.6e-12 46.8 3.2 3.8e-12 45.7 3.2 1.7 1 0 0 1 1 1 1 BTK motif CEP76-C2 PF15627.4 T251540_1 - 0.035 13.6 0.2 5.9 6.3 0.0 2.5 2 0 0 2 2 2 0 CEP76 C2 domain I-set PF07679.14 T043095_1 - 9.3e-105 342.8 0.0 3e-20 71.9 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 T043095_1 - 3.3e-74 245.4 0.1 5.5e-14 52.4 0.0 6.0 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 T043095_1 - 4.2e-48 161.3 0.2 2.7e-09 36.9 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 T043095_1 - 1.5e-47 159.7 0.6 7.7e-09 35.7 0.0 6.0 6 0 0 6 6 6 5 Immunoglobulin domain V-set PF07686.15 T043095_1 - 9e-17 61.1 1.5 0.036 14.1 0.0 7.6 5 3 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 T043095_1 - 9.4e-10 38.3 1.2 0.76 9.8 0.0 5.0 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 T043095_1 - 7.4e-08 32.6 0.5 0.21 12.0 0.0 5.0 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 T043095_1 - 0.0021 17.9 0.0 19 5.2 0.0 3.6 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 T043095_1 - 0.003 17.6 0.0 1.8 8.7 0.0 3.9 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 BiPBP_C PF06832.10 T043095_1 - 0.11 12.4 0.0 6 6.9 0.0 3.1 4 0 0 4 4 4 0 Penicillin-Binding Protein C-terminus Family ENOD40 PF08247.9 T340414_1 - 0.56 10.2 9.5 7.6 6.6 1.4 3.3 2 0 0 2 2 2 0 ENOD40 protein ENOD40 PF08247.9 T340414_3 - 0.49 10.4 9.5 7.6 6.6 1.4 3.4 2 0 0 2 2 2 0 ENOD40 protein Guanylate_kin PF00625.19 T106143_3 - 8.6e-52 175.3 0.0 1.3e-51 174.7 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase L27_N PF09060.8 T106143_3 - 1.2e-23 82.7 5.3 3.2e-23 81.4 5.3 1.8 1 0 0 1 1 1 1 L27_N SH3_2 PF07653.15 T106143_3 - 6.3e-12 44.9 0.0 1.2e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PDZ PF00595.22 T106143_3 - 4.3e-11 42.9 0.5 7.7e-11 42.1 0.5 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) L27 PF02828.14 T106143_3 - 5.4e-06 25.9 1.5 5.4e-06 25.9 1.5 2.3 2 0 0 2 2 2 1 L27 domain SH3_1 PF00018.26 T106143_3 - 1.1e-05 24.8 0.0 2.5e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain PDZ_2 PF13180.4 T106143_3 - 1.2e-05 25.4 0.1 2.4e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.4 T106143_3 - 0.00088 18.9 0.1 0.0017 18.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Peptidase_M13 PF01431.19 T334791_2 - 3e-62 209.7 0.0 4.4e-62 209.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.11 T334791_2 - 7.8e-33 114.6 0.0 1.1e-32 114.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.11 T334791_3 - 2.2e-28 99.9 0.0 6.7e-22 78.6 0.0 2.1 2 0 0 2 2 2 2 Peptidase family M13 Zona_pellucida PF00100.21 T226814_2 - 4.9e-38 131.2 1.8 6.9e-38 130.7 1.8 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain EGF_CA PF07645.13 T226814_2 - 4.8e-07 29.8 6.8 9.7e-07 28.8 6.8 1.6 1 0 0 1 1 1 1 Calcium-binding EGF domain SEA PF01390.18 T226814_2 - 0.00023 21.2 0.2 0.00062 19.9 0.0 1.7 2 0 0 2 2 2 1 SEA domain EGF_3 PF12947.5 T226814_2 - 0.0031 17.6 4.7 0.0063 16.6 4.7 1.5 1 0 0 1 1 1 1 EGF domain fn3 PF00041.19 T226814_2 - 0.0087 16.3 0.0 0.032 14.4 0.0 1.9 2 0 0 2 2 2 1 Fibronectin type III domain hEGF PF12661.5 T226814_2 - 0.22 12.1 4.4 0.9 10.2 4.4 2.1 1 0 0 1 1 1 0 Human growth factor-like EGF Rap_GAP PF02145.13 T217612_3 - 0.003 17.0 0.0 2.7 7.4 0.0 2.6 2 0 0 2 2 2 2 Rap/ran-GAP RUN PF02759.17 T294901_3 - 5.5e-30 103.9 1.1 8e-30 103.4 0.0 1.9 2 0 0 2 2 2 1 RUN domain FYVE PF01363.19 T294901_3 - 7.8e-19 67.5 11.2 7.8e-19 67.5 11.2 2.8 2 0 0 2 2 2 1 FYVE zinc finger HypA PF01155.17 T294901_3 - 0.052 13.4 3.1 0.24 11.3 3.1 2.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TMEM52 PF14979.4 T073791_1 - 2.9e-49 166.6 0.1 4.5e-49 166.0 0.1 1.2 1 0 0 1 1 1 1 Transmembrane 52 TMEM52 PF14979.4 T073791_3 - 0.0025 17.6 0.9 0.0049 16.7 0.9 1.4 1 0 0 1 1 1 1 Transmembrane 52 USP8_dimer PF08969.9 T191932_2 - 1.8e-20 73.1 0.2 3.7e-20 72.1 0.2 1.4 1 0 0 1 1 1 1 USP8 dimerisation domain JAB PF01398.19 T191932_2 - 1e-19 70.5 0.0 1e-19 70.5 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 T191932_2 - 7.9e-06 25.5 0.0 1.6e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF3526 PF12040.6 T191932_2 - 1.3 9.4 5.9 2.3 8.6 5.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3526) PHTB1_N PF14727.4 T321401_3 - 2.9e-164 547.2 0.0 3.7e-164 546.8 0.0 1.1 1 0 0 1 1 1 1 PTHB1 N-terminus PHTB1_C PF14728.4 T321401_3 - 2.8e-156 520.2 2.3 3.6e-156 519.9 2.3 1.1 1 0 0 1 1 1 1 PTHB1 C-terminus zf-C2H2 PF00096.24 T307677_3 - 1.4e-09 37.7 105.4 0.0064 16.8 0.3 17.0 17 0 0 17 17 17 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T307677_3 - 2.6e-06 27.7 98.3 0.47 11.3 2.3 17.0 17 0 0 17 17 17 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T307677_3 - 0.0054 16.5 41.1 0.86 9.5 0.5 8.8 8 0 0 8 8 8 4 C2H2-type zinc finger zinc_ribbon_11 PF11682.6 T307677_3 - 0.026 14.4 0.3 0.08 12.8 0.3 1.8 1 0 0 1 1 1 0 Probable zinc-ribbon zf-C2H2_jaz PF12171.6 T307677_3 - 1.4 9.2 31.5 0.85 9.9 0.1 8.3 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 T307677_3 - 6.1 6.6 12.1 3.9 7.2 0.1 4.4 3 0 0 3 3 3 0 C2H2-type zinc-finger domain DENN PF02141.19 T021473_2 - 5.4e-58 195.9 4.9 5.4e-58 195.9 4.9 1.6 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.16 T021473_2 - 1.2e-16 61.1 0.0 4.8e-16 59.2 0.0 2.2 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 T021473_2 - 6.6e-11 41.9 5.4 1.2e-10 41.0 5.4 1.5 1 0 0 1 1 1 1 dDENN domain PPR_2 PF13041.4 T021473_2 - 0.00095 19.2 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 PPR repeat family PPR_long PF17177.2 T021473_2 - 0.0054 16.0 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PROPR SUIM_assoc PF16619.3 T021473_2 - 0.027 14.4 7.6 0.062 13.3 7.6 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PPR_3 PF13812.4 T021473_2 - 0.1 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Pentatricopeptide repeat domain MAS20 PF02064.13 T021473_2 - 1.8 8.6 6.0 3.2 7.7 6.0 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor TFIIA PF03153.11 T021473_2 - 4.3 7.1 11.4 6.9 6.4 11.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TORC_M PF12885.5 T021473_3 - 5.6e-67 224.5 5.1 5.6e-67 224.5 5.1 2.6 3 0 0 3 3 3 1 Transducer of regulated CREB activity middle domain TORC_C PF12886.5 T021473_3 - 1.8e-27 95.6 0.0 3.1e-27 94.8 0.0 1.4 1 0 0 1 1 1 1 Transducer of regulated CREB activity, C terminus Myosin_tail_1 PF01576.17 T232994_2 - 0 1673.9 313.4 0 1673.7 313.4 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 T232994_2 - 0 1023.3 0.9 0 1023.3 0.9 3.7 4 1 1 5 5 5 1 Myosin head (motor domain) Myosin_N PF02736.17 T232994_2 - 1.2e-09 37.7 2.4 2.6e-09 36.6 2.4 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 T232994_2 - 0.00044 19.7 0.1 0.0017 17.8 0.1 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif ADIP PF11559.6 T232994_2 - 0.0027 17.7 20.2 0.0027 17.7 20.2 14.7 1 1 13 15 15 15 2 Afadin- and alpha -actinin-Binding AAA_22 PF13401.4 T232994_2 - 0.23 11.6 0.0 0.23 11.6 0.0 5.7 5 1 0 5 5 5 0 AAA domain Reo_sigmaC PF04582.10 T232994_2 - 3 7.0 73.4 0.088 12.1 1.9 8.5 2 2 5 9 9 9 0 Reovirus sigma C capsid protein SMI1_KNR4 PF09346.8 T160942_3 - 0.024 14.9 0.0 0.039 14.2 0.0 1.3 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) Inositol_P PF00459.23 T346839_2 - 2.6e-87 292.7 0.1 4e-87 292.1 0.1 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family SBF PF01758.14 T346839_2 - 1e-33 116.5 15.1 2e-33 115.6 15.1 1.4 1 0 0 1 1 1 1 Sodium Bile acid symporter family SNARE PF05739.17 T352929_1 - 0.016 15.0 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 SNARE domain Myb_DNA-bind_5 PF13873.4 T352929_2 - 7.4e-46 154.0 0.1 4.8e-23 80.9 0.0 2.4 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain Syntaxin_2 PF14523.4 T352929_2 - 3.1e-21 75.5 2.7 5.2e-21 74.8 2.7 1.4 1 0 0 1 1 1 1 Syntaxin-like protein Syntaxin PF00804.23 T352929_2 - 0.00032 20.3 5.1 0.00061 19.4 5.1 1.4 1 0 0 1 1 1 1 Syntaxin Myb_DNA-binding PF00249.29 T352929_2 - 0.0032 17.5 0.6 2.1 8.4 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.7 T352929_2 - 0.0035 17.5 0.0 1.8 8.8 0.0 2.4 2 0 0 2 2 2 2 Alcohol dehydrogenase transcription factor Myb/SANT-like CENP-H PF05837.10 T352929_2 - 0.085 13.1 2.1 0.2 11.9 2.1 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) KxDL PF10241.7 T352929_3 - 5.9 7.1 5.1 9.7 6.4 5.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein DUF2367 PF10164.7 T328872_1 - 1.6e-33 115.2 4.3 2.9e-33 114.3 4.3 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2367) Aldo_ket_red PF00248.19 T002082_3 - 7.3e-70 235.3 0.0 4.8e-55 186.6 0.0 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family 7tm_1 PF00001.19 T233250_3 - 5.6e-56 189.6 16.2 7.7e-56 189.1 16.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T233250_3 - 2.6e-11 43.3 6.4 3.4e-11 42.9 6.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 T233250_3 - 1.4e-05 24.4 4.1 2e-05 23.9 4.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 T233250_3 - 0.00039 19.7 1.4 0.00075 18.8 1.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 T233250_3 - 0.011 15.3 2.3 0.022 14.4 2.3 1.4 1 0 0 1 1 1 0 Olfactory receptor 7TM_GPCR_Srw PF10324.7 T233250_3 - 0.32 10.1 1.4 0.4 9.8 0.0 1.8 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw DC_STAMP PF07782.11 T218883_2 - 6.2e-33 114.1 0.1 9.7e-33 113.5 0.1 1.3 1 0 0 1 1 1 1 DC-STAMP-like protein A_deamin PF02137.16 T136326_1 - 6.7e-121 403.6 0.0 9.2e-121 403.1 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain WD40 PF00400.30 T110646_3 - 9.4e-09 35.6 1.8 0.0019 18.8 0.2 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T110646_3 - 0.0003 20.9 0.0 1.5 9.1 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.10 T110646_3 - 0.025 14.4 0.0 7.3 6.5 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DnaJ_CXXCXGXG PF00684.17 T237346_2 - 0.011 15.9 33.8 0.73 10.1 5.9 3.2 1 1 2 3 3 3 0 DnaJ central domain zf-C2H2 PF00096.24 T009052_2 - 2.3e-09 37.1 16.6 0.0033 17.7 1.9 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T009052_2 - 7.6e-07 29.2 0.5 7.6e-07 29.2 0.5 3.6 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.4 T009052_2 - 3.6e-05 24.1 14.4 0.23 12.3 1.0 4.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T009052_2 - 0.0073 16.5 14.7 0.032 14.4 1.0 3.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 T009052_2 - 3.6 7.3 6.4 2.4 7.9 0.8 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Filaggrin PF03516.11 T009052_3 - 1.2 9.8 8.0 48 4.7 4.0 3.7 2 0 0 2 2 2 0 Filaggrin Nop14 PF04147.10 T009052_3 - 4.9 5.1 10.6 6.6 4.7 10.6 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.11 T009052_3 - 6 4.7 10.9 8.5 4.2 10.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi Peptidase_M14 PF00246.22 T081870_1 - 2.1e-48 165.5 0.4 2.7e-48 165.1 0.4 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.4 T081870_1 - 2.4e-07 30.8 0.0 4e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Dioxygenase_C PF00775.19 T081870_1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Dioxygenase Lebercilin PF15619.4 T226316_1 - 3e-48 163.9 25.9 5.1e-48 163.2 25.9 1.4 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Lebercilin PF15619.4 T226316_3 - 1.1e-11 44.6 5.0 1.1e-11 44.6 5.0 2.1 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease DUF3519 PF12033.6 T226316_3 - 0.008 16.4 1.5 0.023 15.0 1.5 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3519) STAT_bind PF02864.13 T080285_1 - 1.2e-63 215.2 0.0 1.6e-63 214.7 0.0 1.2 1 0 0 1 1 1 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 T080285_1 - 6.3e-39 133.5 4.2 9.9e-39 132.9 4.2 1.2 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT2_C PF12188.6 T080285_1 - 1.5e-32 111.2 0.7 1.5e-32 111.2 0.7 2.2 3 0 0 3 3 3 1 Signal transducer and activator of transcription 2 C terminal SH2 PF00017.22 T080285_1 - 1.2e-10 41.2 0.0 2.7e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 SH2 domain Apolipo_F PF15148.4 T080285_2 - 1.4e-88 295.5 0.0 1.9e-88 295.1 0.0 1.2 1 0 0 1 1 1 1 Apolipoprotein F STAT_int PF02865.15 T080285_3 - 2.1e-30 105.5 2.9 2.1e-30 105.5 2.9 1.5 2 0 0 2 2 2 1 STAT protein, protein interaction domain STAT_alpha PF01017.18 T080285_3 - 4.4e-07 29.8 0.4 7.3e-07 29.1 0.4 1.3 1 0 0 1 1 1 1 STAT protein, all-alpha domain GAS PF13851.4 T139044_2 - 4.8e-81 270.8 27.9 4.8e-81 270.8 27.9 1.5 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding Virulence_fact PF13769.4 T139044_2 - 0.028 14.4 0.8 0.028 14.4 0.8 2.8 3 0 0 3 3 3 0 Virulence factor DNA_repr_REX1B PF14966.4 T139044_2 - 0.03 14.8 7.0 0.059 13.9 0.5 2.5 2 0 0 2 2 2 0 DNA repair REX1-B 5_nucleotid PF05761.12 T139044_2 - 0.79 8.4 8.7 1.3 7.7 8.7 1.3 1 0 0 1 1 1 0 5' nucleotidase family Baculo_PEP_C PF04513.10 T139044_2 - 1.2 9.0 9.1 9.7 6.1 0.5 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lebercilin PF15619.4 T139044_2 - 7.4 6.0 38.8 0.42 10.1 19.9 3.1 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease V-set PF07686.15 T112230_2 - 2.9e-15 56.2 0.1 4e-15 55.8 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T112230_2 - 0.0021 18.5 0.1 0.0058 17.1 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T112230_2 - 0.033 14.2 0.2 0.11 12.6 0.2 1.8 1 1 0 1 1 1 0 Immunoglobulin domain zf-C4 PF00105.16 T027571_3 - 1.1e-31 109.0 12.0 2.2e-31 108.0 12.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 T027571_3 - 9.2e-31 106.9 6.6 1.4e-30 106.3 6.6 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Fam20C PF06702.10 T025798_2 - 2.6e-85 285.5 0.0 4.2e-85 284.8 0.0 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.4 T025798_2 - 0.015 14.1 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 FAM198 protein NPIP PF06409.9 T031107_3 - 2.6e-08 33.3 37.8 9.1e-06 24.9 13.3 3.7 3 1 0 3 3 3 2 Nuclear pore complex interacting protein (NPIP) IncA PF04156.12 T031107_3 - 0.0051 16.5 17.1 0.0051 16.5 17.1 4.3 2 2 2 4 4 4 2 IncA protein zf-C4H2 PF10146.7 T031107_3 - 0.0056 16.8 1.6 0.0056 16.8 1.6 3.4 2 1 1 3 3 3 1 Zinc finger-containing protein PhyH PF05721.11 T031107_3 - 0.17 12.0 0.4 0.43 10.7 0.4 1.6 1 0 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) WW PF00397.24 T068109_2 - 1.9e-05 24.4 0.0 4.5e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 WW domain Ank_2 PF12796.5 T269780_1 - 2.9e-149 485.9 45.6 1.3e-17 64.0 0.2 12.3 1 1 11 12 12 12 12 Ankyrin repeats (3 copies) Ank PF00023.28 T269780_1 - 3e-134 432.0 70.4 5.3e-07 29.7 0.5 23.5 22 1 1 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 T269780_1 - 1.3e-124 405.0 34.1 1.8e-12 47.4 0.1 15.3 7 4 9 17 17 17 17 Ankyrin repeats (many copies) Ank_5 PF13857.4 T269780_1 - 2.3e-119 387.2 48.6 2.7e-11 43.4 0.6 18.5 3 3 17 20 20 20 20 Ankyrin repeats (many copies) Ank_3 PF13606.4 T269780_1 - 3.5e-113 355.6 34.6 3.7e-05 23.7 0.0 24.0 23 0 0 23 23 23 21 Ankyrin repeat ZU5 PF00791.18 T269780_1 - 2e-34 117.7 0.5 2.1e-26 92.0 0.0 2.7 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 T269780_1 - 5.4e-22 77.6 0.9 1.1e-21 76.6 0.9 1.6 1 0 0 1 1 1 1 Death domain PK_C PF02887.14 T269780_1 - 3.5e-06 27.1 2.5 7 6.8 0.0 5.9 5 1 1 6 6 6 2 Pyruvate kinase, alpha/beta domain HTH_23 PF13384.4 T269780_1 - 0.11 12.2 0.1 1.4 8.7 0.1 3.0 2 0 0 2 2 2 0 Homeodomain-like domain MatE PF01554.16 T143716_1 - 6.6e-59 198.0 21.4 2e-30 105.4 2.2 2.5 2 0 0 2 2 2 2 MatE DUF2681 PF10883.6 T143716_1 - 0.86 9.9 3.2 0.3 11.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) LRR_8 PF13855.4 T192441_3 - 3.1e-54 180.4 56.5 1.9e-14 53.0 3.9 5.3 1 1 4 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 T192441_3 - 7.1e-17 61.0 33.8 4e-05 23.7 3.9 6.2 4 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 T192441_3 - 2.1e-10 40.2 5.0 0.00011 21.6 2.0 2.7 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.31 T192441_3 - 0.0066 16.6 28.2 6 7.6 0.4 9.5 9 0 0 9 9 9 1 Leucine Rich Repeat LRRNT PF01462.16 T192441_3 - 0.21 11.1 3.3 1.2 8.8 3.3 2.4 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain REV PF00424.16 T368001_1 - 0.035 14.0 2.5 0.19 11.7 2.5 2.2 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) Homeobox PF00046.27 T368001_2 - 1.6e-21 75.8 5.6 3e-21 74.9 5.6 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox PF00046.27 T063434_3 - 8.7e-23 79.8 2.8 1.4e-22 79.1 2.8 1.3 1 0 0 1 1 1 1 Homeobox domain Hormone_recep PF00104.28 T122862_1 - 4e-39 134.2 0.1 6e-39 133.6 0.1 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 T122862_1 - 5.8e-31 106.6 16.3 1.4e-30 105.4 16.3 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Dynein_heavy PF03028.13 T141126_1 - 1.4e-263 876.3 0.7 2.9e-261 868.6 0.0 3.6 4 0 0 4 4 4 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.5 T141126_1 - 2.5e-88 294.8 0.2 6.9e-88 293.3 0.2 1.8 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.5 T141126_1 - 1.5e-52 178.6 9.1 2e-52 178.2 9.1 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.5 T141126_1 - 4.4e-44 150.5 0.1 6.9e-44 149.9 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Sec34 PF04136.13 T141126_1 - 5.2 6.8 16.6 1.2 8.9 2.7 3.2 2 1 1 3 3 3 0 Sec34-like family DUF4201 PF13870.4 T141126_1 - 6.6 6.2 27.7 5.3 6.5 8.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Exonuc_VII_L PF02601.13 T141126_1 - 8 5.8 13.3 5.8 6.2 0.4 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit JmjC PF02373.20 T141126_3 - 1.9e-31 108.7 1.6 3.2e-31 108.0 1.6 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase Pkinase PF00069.23 T064476_3 - 1e-72 244.6 0.0 1.4e-72 244.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T064476_3 - 2.9e-46 157.7 0.0 4.6e-46 157.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 T064476_3 - 8.8e-25 86.8 0.0 2.2e-24 85.5 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 T064476_3 - 1.7e-07 30.7 0.0 0.0006 19.1 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.21 T064476_3 - 0.041 13.7 0.0 0.3 10.8 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DSHCT PF08148.10 T064476_3 - 0.055 13.0 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain Kdo PF06293.12 T064476_3 - 0.14 11.3 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PhyH PF05721.11 T367283_1 - 1.1e-21 78.0 0.0 1.5e-21 77.5 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) PhyH PF05721.11 T367283_3 - 1.8e-23 83.8 0.3 6.9e-18 65.5 0.1 2.2 1 1 1 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Myosin_head PF00063.19 T170274_1 - 1.1e-214 714.4 10.9 9.1e-182 605.7 3.0 2.3 2 0 0 2 2 2 2 Myosin head (motor domain) RhoGAP PF00620.25 T170274_1 - 2.1e-45 154.1 0.1 5.2e-45 152.8 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain RA PF00788.21 T170274_1 - 1.3e-17 64.1 4.0 1.2e-15 57.7 0.0 3.5 3 0 0 3 3 3 2 Ras association (RalGDS/AF-6) domain IQ PF00612.25 T170274_1 - 5.1e-13 47.5 31.4 0.00078 18.9 2.2 5.4 5 0 0 5 5 5 4 IQ calmodulin-binding motif C1_1 PF00130.20 T170274_1 - 0.00011 21.9 11.4 0.00025 20.7 11.4 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.3 T170274_1 - 1.7 8.7 7.4 3.7 7.6 7.4 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger RGM_N PF06535.10 T170274_1 - 2 8.6 6.8 0.12 12.5 0.4 2.2 3 0 0 3 3 3 0 Repulsive guidance molecule (RGM) N-terminus zf-RING_9 PF13901.4 T170274_1 - 4.1 7.2 11.6 0.17 11.7 5.0 2.1 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Use1 PF09753.7 T170274_2 - 1.3e-91 306.6 8.4 1.3e-91 306.6 8.4 2.0 2 0 0 2 2 2 1 Membrane fusion protein Use1 MCU PF04678.11 T170274_2 - 0.012 15.7 1.2 0.02 14.9 1.2 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Prominin PF05478.9 T170274_2 - 0.066 11.0 0.4 0.094 10.5 0.4 1.1 1 0 0 1 1 1 0 Prominin Peptidase_C69 PF03577.13 T203213_2 - 1.7e-09 37.2 0.1 2.4e-09 36.7 0.1 1.1 1 0 0 1 1 1 1 Peptidase family C69 AAT PF03417.14 T203213_2 - 0.014 15.0 0.0 0.034 13.7 0.0 1.6 2 0 0 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase DUF1725 PF08333.9 T359696_1 - 0.049 13.2 0.1 0.13 11.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) CobW_C PF07683.12 T359696_2 - 4.3e-17 61.7 0.0 6.7e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain CFTR_R PF14396.4 T331785_3 - 6.3e-101 336.2 1.9 9.6e-101 335.6 1.9 1.3 1 0 0 1 1 1 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 T331785_3 - 2.1e-91 306.3 42.3 1.5e-49 169.0 20.7 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 T331785_3 - 1.6e-58 196.9 0.0 7.5e-33 113.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 T331785_3 - 4.9e-07 29.7 1.7 0.045 13.4 0.1 3.3 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 T331785_3 - 8.2e-07 28.5 0.0 0.025 13.9 0.0 3.2 2 2 0 3 3 3 1 RecF/RecN/SMC N terminal domain T2SSE PF00437.18 T331785_3 - 1.7e-05 23.9 0.2 0.069 12.1 0.0 2.2 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.4 T331785_3 - 2.1e-05 24.0 3.9 0.0013 18.3 0.0 3.1 3 0 0 3 3 3 1 P-loop containing region of AAA domain DUF258 PF03193.14 T331785_3 - 5.5e-05 23.0 0.6 0.051 13.3 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 DUF87 PF01935.15 T331785_3 - 9.6e-05 22.4 0.6 0.11 12.4 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function DUF87 AAA_16 PF13191.4 T331785_3 - 0.0006 20.1 0.0 0.48 10.6 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.21 T331785_3 - 0.003 17.5 0.0 0.43 10.5 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase ArgK PF03308.14 T331785_3 - 0.004 16.1 0.8 0.02 13.7 0.1 2.0 2 0 0 2 2 2 1 ArgK protein Zeta_toxin PF06414.10 T331785_3 - 0.0044 16.2 0.4 0.61 9.2 0.1 2.5 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.10 T331785_3 - 0.005 16.6 0.8 3.7 7.3 0.1 2.5 2 0 0 2 2 2 2 NACHT domain Roc PF08477.11 T331785_3 - 0.023 14.8 0.1 6.3 6.9 0.0 3.5 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.13 T331785_3 - 0.028 14.2 0.2 0.49 10.1 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_22 PF13401.4 T331785_3 - 0.03 14.5 0.4 4.9 7.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.4 T331785_3 - 0.031 13.9 0.0 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.16 T331785_3 - 0.069 12.4 0.6 7.8 5.6 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_19 PF13245.4 T331785_3 - 0.077 13.2 0.1 31 4.7 0.0 3.0 2 1 0 2 2 2 0 AAA domain TsaE PF02367.15 T331785_3 - 0.12 12.2 0.6 19 5.1 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MobB PF03205.12 T331785_3 - 0.24 11.2 1.4 24 4.7 0.1 2.9 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.17 T331785_3 - 0.31 10.5 1.8 13 5.2 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.4 T331785_3 - 1 9.7 13.0 1.5 9.1 0.0 3.8 4 0 0 4 4 4 0 AAA domain 7tm_4 PF13853.4 T167762_1 - 1.9e-54 185.1 20.3 2.7e-54 184.6 20.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T167762_1 - 3.1e-23 82.2 18.7 5.9e-23 81.3 18.7 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T167762_1 - 0.00057 19.2 19.6 0.00092 18.5 19.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4801 PF16059.3 T115095_1 - 2.1e-16 59.5 8.9 4.8e-16 58.4 8.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4801) HLH PF00010.24 T115095_1 - 1e-08 34.9 0.2 2.3e-08 33.8 0.2 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Myotub-related PF06602.12 T113675_2 - 1.6e-70 237.6 2.9 2.3e-57 194.3 2.0 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain 3-PAP PF12578.6 T113675_3 - 7.6e-54 180.9 0.1 1.2e-53 180.3 0.1 1.3 1 0 0 1 1 1 1 Myotubularin-associated protein EF-hand_4 PF12763.5 T146271_1 - 0.054 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DEAD PF00270.27 T146271_2 - 2.6e-36 124.9 0.0 3.7e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T146271_2 - 4.1e-29 101.1 0.1 1.2e-28 99.6 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 T146271_2 - 0.0003 20.7 0.0 0.00065 19.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 T146271_2 - 0.013 15.7 0.0 0.021 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain CK1gamma_C PF12605.6 T146271_2 - 0.18 12.9 0.6 0.43 11.6 0.6 1.5 1 0 0 1 1 1 0 Casein kinase 1 gamma C terminal AXH PF08517.10 T298125_2 - 8.7e-44 148.6 0.1 8.7e-44 148.6 0.1 1.8 2 0 0 2 2 2 1 Ataxin-1 and HBP1 module (AXH) ATXN-1_C PF12547.6 T298125_2 - 9.6e-08 32.1 5.3 7.9e-06 26.0 2.7 3.2 1 1 1 2 2 2 2 Capicua transcriptional repressor modulator Spt20 PF12090.6 T298125_2 - 0.076 12.5 22.7 0.14 11.6 22.7 1.3 1 0 0 1 1 1 0 Spt20 family CFIA_Pcf11 PF11526.6 T298125_2 - 0.71 10.3 7.1 1.8 9.0 7.1 1.6 1 0 0 1 1 1 0 Subunit of cleavage factor IA Pcf11 TERB2 PF15101.4 T298125_2 - 1.6 8.6 6.2 3.1 7.7 6.2 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PGC7_Stella PF15549.4 T298125_2 - 1.8 8.3 14.2 3.8 7.3 14.2 1.5 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain Presenilin PF01080.15 T298125_2 - 2 6.9 5.6 3.8 6.0 5.6 1.4 1 0 0 1 1 1 0 Presenilin Suf PF05843.12 T298125_2 - 6.2 6.6 10.9 11 5.7 10.9 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) COesterase PF00135.26 T134167_2 - 2.5e-131 439.0 0.0 3.2e-131 438.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 T134167_2 - 0.00011 22.0 0.8 0.00036 20.3 0.8 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold RNase_Zc3h12a PF11977.6 T375627_1 - 3.7e-63 211.8 0.0 5.7e-63 211.2 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain zf-CCCH_2 PF14608.4 T375627_1 - 7.6 7.0 9.7 42 4.7 9.7 2.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Rootletin PF15035.4 T004349_2 - 1.3e-64 217.5 25.4 1.3e-64 217.5 25.4 14.4 4 3 8 12 12 12 1 Ciliary rootlet component, centrosome cohesion Fez1 PF06818.13 T004349_2 - 0.0002 21.8 2.9 0.0002 21.8 2.9 12.7 4 3 9 13 13 13 2 Fez1 Aha1_N PF09229.9 T190178_2 - 3.2e-22 79.1 0.5 5e-22 78.4 0.5 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.9 T190178_3 - 0.011 15.9 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 0 Activator of Hsp90 ATPase homolog 1-like protein 7tm_2 PF00002.22 T304734_2 - 6.1e-59 199.1 53.7 2.6e-30 105.4 23.3 2.4 2 0 0 2 2 2 2 7 transmembrane receptor (Secretin family) GPS PF01825.19 T304734_2 - 4e-17 62.4 8.9 3.9e-09 36.9 0.6 3.0 2 0 0 2 2 2 2 GPCR proteolysis site, GPS, motif APG5 PF04106.10 T304734_2 - 0.0003 20.5 0.3 0.27 10.9 0.0 2.3 2 0 0 2 2 2 2 Autophagy protein Apg5 TMEM154 PF15102.4 T304734_2 - 1.9 8.3 4.1 23 4.7 0.1 2.6 2 0 0 2 2 2 0 TMEM154 protein family Pkinase PF00069.23 T177728_1 - 7.4e-69 231.9 0.0 1e-68 231.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T177728_1 - 1.3e-31 109.7 0.0 2e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 T177728_1 - 5.9e-24 83.6 26.3 6.5e-13 48.2 2.6 2.9 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.14 T177728_1 - 1.5e-06 28.3 14.8 0.005 17.0 5.4 2.8 2 0 0 2 2 2 2 C1 domain Kinase-like PF14531.4 T177728_1 - 0.00011 21.5 0.0 0.00054 19.2 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.12 T177728_1 - 0.00022 20.5 0.0 0.00039 19.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_9 PF13901.4 T177728_1 - 0.32 10.8 12.7 1.2 9.0 0.4 2.2 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD_2 PF13831.4 T177728_1 - 1.1 8.7 4.7 15 5.1 0.1 2.9 2 0 0 2 2 2 0 PHD-finger Striatin PF08232.10 T177728_2 - 1.5e-42 145.7 3.6 4.3e-42 144.2 3.6 1.8 1 1 0 1 1 1 1 Striatin family WD40 PF00400.30 T177728_2 - 3.3e-33 113.0 15.4 2.6e-09 37.4 0.4 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T177728_2 - 6.2e-09 35.9 0.0 0.094 12.9 0.0 4.4 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 T177728_2 - 0.0004 19.0 0.0 0.73 8.2 0.0 3.0 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.9 T177728_2 - 0.12 11.0 0.0 7.1 5.1 0.0 2.6 3 0 0 3 3 3 0 Nup133 N terminal like CENP-H PF05837.10 T177728_2 - 0.29 11.4 1.8 20 5.5 0.4 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Kelch_1 PF01344.23 T377090_2 - 5.6e-78 256.2 18.3 7e-16 57.4 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 T377090_2 - 5.5e-48 159.6 7.7 7.5e-09 35.4 0.1 6.4 3 2 3 6 6 6 6 Kelch motif BACK PF07707.13 T377090_2 - 6.3e-31 106.4 0.1 2.5e-30 104.5 0.0 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_4 PF13418.4 T377090_2 - 3.2e-29 100.5 4.6 0.0001 22.1 0.1 6.3 5 1 1 6 6 6 5 Galactose oxidase, central domain BTB PF00651.29 T377090_2 - 8.5e-29 99.9 1.6 2.1e-28 98.7 0.7 2.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.13 T377090_2 - 4.5e-27 92.8 9.6 3.3e-05 23.6 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.4 T377090_2 - 3.5e-18 65.3 12.8 0.00018 21.6 0.1 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 T377090_2 - 1e-08 34.8 6.6 0.93 9.4 0.0 6.4 7 0 0 7 7 7 3 Kelch motif IPK PF03770.14 T242311_2 - 9.5e-61 205.0 0.0 1.5e-60 204.4 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase Hormone_2 PF00123.18 T313786_3 - 2.6e-27 94.3 1.8 1.3e-13 50.5 0.1 2.4 2 0 0 2 2 2 2 Peptide hormone zf-H2C2_2 PF13465.4 T090501_1 - 3.8e-86 279.8 68.3 7.3e-08 32.4 0.3 14.2 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 T090501_1 - 1.2e-61 201.7 83.0 1.8e-05 24.8 0.8 14.4 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T090501_1 - 7.5e-33 110.2 92.9 0.01 16.5 1.8 14.5 14 0 0 14 14 14 13 C2H2-type zinc finger KRAB PF01352.25 T090501_1 - 4.5e-19 67.7 0.2 8e-19 66.9 0.2 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T090501_1 - 7.3e-09 35.2 83.1 0.36 10.7 0.3 13.7 13 0 0 13 13 13 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T090501_1 - 0.0016 18.4 61.4 0.055 13.5 0.6 8.0 5 2 5 10 10 10 5 Zinc ribbon domain C1_4 PF07975.10 T090501_1 - 0.0057 16.8 49.8 0.36 11.0 1.7 8.5 3 2 7 10 10 10 4 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 T090501_1 - 1.8 9.2 50.3 2.2 8.9 0.3 7.1 1 1 5 7 7 7 0 zinc-ribbon family DUF899 PF05988.10 T090501_1 - 8.1 5.8 10.1 44 3.4 0.1 4.3 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF899) CpXC PF14353.4 T090501_1 - 9.7 6.1 42.9 1.9 8.4 0.1 10.1 2 2 5 10 10 10 0 CpXC protein IRF PF00605.15 T052308_1 - 7.3e-37 125.7 0.0 1.1e-36 125.1 0.0 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Hormone_2 PF00123.18 T052308_1 - 1.9e-06 27.6 0.0 3.1e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Peptide hormone Cadherin PF00028.15 T052308_2 - 5.6e-13 49.0 0.7 0.00057 20.2 0.0 3.6 3 0 0 3 3 3 3 Cadherin domain Cadherin_3 PF16184.3 T052308_2 - 0.0016 18.3 0.1 0.0043 16.9 0.1 1.7 1 0 0 1 1 1 1 Cadherin-like IRF-3 PF10401.7 T052308_3 - 2.3e-46 157.7 0.0 3.7e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 Scramblase PF03803.13 T140945_2 - 0.028 13.6 0.0 0.039 13.1 0.0 1.1 1 0 0 1 1 1 0 Scramblase Scramblase PF03803.13 T140945_3 - 6.7e-46 156.2 0.0 9e-46 155.8 0.0 1.1 1 0 0 1 1 1 1 Scramblase SPAR_C PF11881.6 T106854_3 - 1.2e-83 280.6 14.8 1.2e-83 280.6 14.8 2.4 2 0 0 2 2 1 1 C-terminal domain of SPAR protein Rap_GAP PF02145.13 T106854_3 - 5.8e-68 228.0 0.1 1e-67 227.2 0.1 1.4 1 0 0 1 1 1 1 Rap/ran-GAP PDZ PF00595.22 T106854_3 - 0.00014 22.0 0.0 0.00027 21.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DUF4164 PF13747.4 T106854_3 - 0.011 15.9 1.7 0.027 14.6 1.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Rootletin PF15035.4 T106854_3 - 0.014 15.3 4.6 0.034 14.1 4.6 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion ATG16 PF08614.9 T106854_3 - 0.034 14.2 7.9 0.11 12.5 7.9 1.8 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF2046 PF09755.7 T106854_3 - 0.04 13.0 4.2 0.075 12.1 4.2 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Sec34 PF04136.13 T106854_3 - 0.065 13.0 1.3 0.17 11.6 1.3 1.6 1 0 0 1 1 1 0 Sec34-like family TMF_TATA_bd PF12325.6 T106854_3 - 0.082 13.0 3.0 0.22 11.6 3.0 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding IncA PF04156.12 T106854_3 - 0.14 11.8 7.5 0.33 10.6 7.5 1.6 1 0 0 1 1 1 0 IncA protein DUF972 PF06156.11 T106854_3 - 0.24 11.9 2.6 0.75 10.3 2.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF972) ZapB PF06005.10 T106854_3 - 1.6 9.1 8.4 3.5 8.0 8.4 1.5 1 0 0 1 1 1 0 Cell division protein ZapB MFS_1 PF07690.14 T299043_2 - 8.3e-73 245.2 75.6 7.7e-45 153.2 29.7 5.2 4 1 1 5 5 5 4 Major Facilitator Superfamily FAM184 PF15665.3 T310459_2 - 1.2e-82 276.7 37.2 1.2e-82 276.7 37.2 5.5 2 1 2 5 5 5 2 Family with sequence similarity 184, A and B DP PF08781.8 T099797_3 - 1.9e-64 215.6 1.0 3.7e-64 214.6 1.0 1.5 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.18 T099797_3 - 1.2e-26 92.4 0.1 2.3e-26 91.5 0.1 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain CK1gamma_C PF12605.6 T288201_3 - 4.2e-32 111.1 7.4 6.6e-32 110.5 7.4 1.3 1 0 0 1 1 1 1 Casein kinase 1 gamma C terminal Pkinase PF00069.23 T288201_3 - 1e-25 90.5 0.0 1.8e-25 89.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T288201_3 - 6.5e-14 51.7 0.0 1.6e-13 50.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Arm PF00514.21 T059007_1 - 1.2e-30 104.4 5.8 1.6e-07 30.9 0.0 7.1 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 T059007_1 - 0.00018 21.8 0.2 14 6.1 0.0 4.4 4 0 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.4 T059007_1 - 0.0071 16.6 0.4 3.2 8.0 0.1 2.5 2 0 0 2 2 2 2 HEAT repeats Cnd1 PF12717.5 T059007_1 - 0.024 14.5 0.8 0.075 12.9 0.2 2.0 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Pkinase_Tyr PF07714.15 T201523_1 - 3.8e-31 108.2 0.1 5.2e-31 107.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T201523_1 - 1.1e-29 103.5 0.0 1.5e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 T201523_1 - 1e-14 53.5 0.1 1.9e-14 52.7 0.1 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif DENN PF02141.19 T058143_1 - 3.4e-33 115.0 1.5 6.8e-33 114.1 1.5 1.5 1 1 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 T058143_1 - 6e-18 65.3 0.6 1.6e-17 63.9 0.6 1.8 1 0 0 1 1 1 1 uDENN domain Hormone_recep PF00104.28 T058143_2 - 8.8e-29 100.4 1.8 1.3e-28 99.9 1.8 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 T058143_2 - 2e-26 92.1 13.9 5.7e-26 90.6 13.9 1.9 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ADK PF00406.20 T013505_3 - 1.4e-79 265.3 0.1 7.4e-44 149.4 0.0 2.2 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.4 T013505_3 - 1.7e-56 190.2 0.3 1.4e-29 103.1 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.4 T013505_3 - 5.7e-15 55.8 0.1 1.6e-07 31.7 0.0 3.3 2 1 1 3 3 3 2 AAA domain AAA_33 PF13671.4 T013505_3 - 1.2e-10 41.6 0.0 0.00062 19.8 0.0 2.7 2 2 0 2 2 2 2 AAA domain Cytidylate_kin PF02224.16 T013505_3 - 0.00013 21.6 0.1 0.65 9.6 0.0 2.5 2 1 1 3 3 3 2 Cytidylate kinase AAA_28 PF13521.4 T013505_3 - 0.00022 21.4 0.0 0.49 10.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.10 T013505_3 - 0.00035 19.8 0.4 0.088 12.0 0.0 2.5 3 0 0 3 3 3 2 Zeta toxin Hydin_ADK PF17213.1 T013505_3 - 0.0016 18.6 0.0 0.55 10.4 0.0 2.2 2 0 0 2 2 2 2 Hydin Adenylate kinase-like domain Thymidylate_kin PF02223.15 T013505_3 - 0.0026 17.3 3.5 0.48 9.9 0.1 3.5 4 0 0 4 4 4 1 Thymidylate kinase AAA_22 PF13401.4 T013505_3 - 0.0045 17.1 0.1 0.42 10.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.4 T013505_3 - 0.0049 17.1 0.7 4.1 7.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA PF00004.27 T013505_3 - 0.074 13.4 0.2 10 6.4 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) dNK PF01712.17 T013505_3 - 0.39 10.4 6.8 5.5 6.7 0.0 3.0 4 0 0 4 4 4 0 Deoxynucleoside kinase HlyIII PF03006.18 T005972_1 - 8.6e-50 169.4 17.1 1.4e-49 168.7 17.1 1.3 1 0 0 1 1 1 1 Haemolysin-III related Lipoxygenase PF00305.17 T140671_1 - 5.1e-59 200.2 0.0 1.8e-58 198.4 0.0 1.7 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.21 T140671_1 - 1.2e-18 67.6 0.0 2e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain DUF2650 PF10853.6 T140671_2 - 0.11 12.1 0.2 0.26 11.0 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2650) Myb_DNA-binding PF00249.29 T140671_3 - 0.0056 16.7 0.1 0.013 15.6 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 T140671_3 - 0.0085 15.8 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 Myb DNA-binding like 7tm_2 PF00002.22 T240899_1 - 1.5e-65 220.8 3.7 2.4e-65 220.1 3.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.9 T240899_1 - 0.78 8.7 8.2 1.2 8.1 8.2 1.1 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor 7tm_2 PF00002.22 T240899_2 - 2.8e-11 43.1 0.0 5.1e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 T240899_3 - 1.8e-17 63.3 0.8 5.6e-17 61.7 0.8 1.9 1 0 0 1 1 1 1 Hormone receptor domain 7tm_2 PF00002.22 T240899_3 - 0.14 11.3 0.8 0.22 10.7 0.8 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) Trypsin PF00089.24 T032021_1 - 1.8e-09 37.6 0.0 2.8e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin PF00089.24 T032021_2 - 1e-26 94.0 4.6 4.5e-13 49.4 0.6 2.3 2 0 0 2 2 2 2 Trypsin C2 PF00168.28 T119458_3 - 3.1e-07 30.5 0.1 1.6e-05 25.0 0.1 2.4 2 0 0 2 2 2 2 C2 domain Tmemb_40 PF10160.7 T249962_1 - 5.9e-91 304.3 12.5 7.5e-91 303.9 12.5 1.1 1 0 0 1 1 1 1 Predicted membrane protein DUF3681 PF12442.6 T249962_1 - 3.1 8.3 6.8 0.85 10.1 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3681) Ctr PF04145.13 T364961_1 - 1.3e-28 100.3 2.9 1.3e-28 100.3 2.9 1.9 2 0 0 2 2 2 1 Ctr copper transporter family MLTD_N PF06474.10 T364961_2 - 2.3 8.3 6.8 4.2 7.5 0.4 2.7 2 0 0 2 2 2 0 MltD lipid attachment motif Peptidase_M19 PF01244.19 T134965_3 - 9.7e-101 337.0 0.0 1.2e-100 336.6 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) I-set PF07679.14 T085124_1 - 1.8e-90 297.0 0.4 5.8e-18 64.6 0.0 7.3 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.4 T085124_1 - 4.1e-59 197.0 0.1 1.1e-12 48.2 0.1 7.4 7 0 0 7 7 7 7 Immunoglobulin domain fn3 PF00041.19 T085124_1 - 1.1e-40 137.7 0.0 2.2e-13 50.2 0.0 3.7 3 0 0 3 3 3 3 Fibronectin type III domain Ig_2 PF13895.4 T085124_1 - 4.3e-29 100.6 0.1 3e-07 30.6 0.2 7.5 7 0 0 7 7 7 6 Immunoglobulin domain ig PF00047.23 T085124_1 - 1.1e-27 95.9 2.2 7.7e-08 32.3 0.0 7.5 8 0 0 8 8 8 5 Immunoglobulin domain V-set PF07686.15 T085124_1 - 2.7e-08 33.8 2.9 0.47 10.5 0.1 7.4 7 2 0 7 7 7 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 T085124_1 - 3e-05 23.9 0.8 0.48 10.4 0.0 4.3 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain CDP-OH_P_transf PF01066.19 T085124_3 - 4.9e-17 62.3 0.1 1.9e-16 60.4 0.1 2.2 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase CARD PF00619.19 T134255_1 - 6.1e-17 61.3 0.0 8.9e-17 60.8 0.0 1.2 1 0 0 1 1 1 1 Caspase recruitment domain F-box-like PF12937.5 T134255_1 - 1.7e-09 37.3 0.2 3.5e-09 36.3 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T134255_1 - 2.1e-06 27.3 0.0 5.3e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 F-box domain HSF_DNA-bind PF00447.15 T134255_2 - 7.1e-23 80.9 0.2 1.2e-22 80.2 0.2 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding zf-C2H2 PF00096.24 T206976_3 - 6.8e-08 32.4 40.6 0.00082 19.6 1.3 6.6 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T206976_3 - 1.9e-07 31.1 38.0 8.9e-07 29.0 2.8 6.1 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 T206976_3 - 2.5e-05 24.6 35.3 0.01 16.4 1.1 6.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T206976_3 - 0.0033 17.0 0.9 0.0033 17.0 0.9 4.9 4 0 0 4 4 4 2 C2H2-type zinc-finger domain IL1 PF00340.17 T067289_1 - 2.7e-35 120.5 0.7 4.9e-35 119.7 0.7 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 APG5 PF04106.10 T308978_3 - 2.7e-58 196.8 0.1 3.8e-58 196.3 0.1 1.2 1 0 0 1 1 1 1 Autophagy protein Apg5 Acyltransferase PF01553.19 T342864_3 - 2.4e-18 65.9 0.1 4.9e-18 64.9 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase Hox9_act PF04617.11 T203384_1 - 9.3e-49 166.6 4.9 7.5e-48 163.6 1.4 2.5 1 1 1 2 2 2 1 Hox9 activation region Homeobox PF00046.27 T203384_1 - 3.6e-39 132.2 19.8 1.4e-19 69.5 5.8 2.5 2 0 0 2 2 2 2 Homeobox domain Ada3 PF10198.7 T203384_1 - 0.0068 16.4 1.2 2.3 8.2 0.0 2.2 2 0 0 2 2 2 2 Histone acetyltransferases subunit 3 HTH_23 PF13384.4 T203384_1 - 0.014 15.1 0.1 0.36 10.6 0.0 2.6 2 0 0 2 2 2 0 Homeodomain-like domain CI-B14_5a PF07347.10 T203384_1 - 0.032 14.0 0.3 2.6 7.8 0.0 2.6 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Homeobox_KN PF05920.9 T203384_1 - 0.47 10.3 12.6 0.28 11.0 0.3 3.2 3 0 0 3 3 3 0 Homeobox KN domain Homeobox PF00046.27 T203384_2 - 1.7e-19 69.2 8.0 3e-19 68.5 8.0 1.4 1 0 0 1 1 1 1 Homeobox domain Hist_deacetyl PF00850.17 T210879_3 - 5.4e-80 269.0 0.0 5.4e-80 269.0 0.0 2.2 2 0 0 2 2 2 1 Histone deacetylase domain HDAC4_Gln PF12203.6 T210879_3 - 3.8e-36 123.0 46.2 3.8e-36 123.0 46.2 3.0 2 1 1 3 3 3 1 Glutamine rich N terminal domain of histone deacetylase 4 TFIIA PF03153.11 T210879_3 - 8.6 6.1 38.7 4.1 7.2 16.4 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit MACPF PF01823.17 T011727_3 - 6.1e-37 127.6 2.4 5.8e-36 124.4 0.2 2.8 3 0 0 3 3 3 1 MAC/Perforin domain Ldl_recept_a PF00057.16 T011727_3 - 1e-07 31.9 13.2 1e-07 31.9 13.2 2.0 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.17 T011727_3 - 1.4e-05 25.1 27.9 8.1e-05 22.6 10.8 2.9 2 0 0 2 2 2 2 Thrombospondin type 1 domain DUF3789 PF12664.5 T292463_1 - 0.11 12.0 0.8 0.24 11.0 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3789) Neur_chan_LBD PF02931.21 T292463_2 - 4.6e-50 169.9 0.0 6.2e-50 169.5 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 T292463_2 - 2.3e-38 132.5 2.5 2.7e-30 106.1 5.1 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Myosin_head PF00063.19 T154513_1 - 8e-50 169.6 0.0 1.9e-49 168.4 0.0 1.5 2 0 0 2 2 2 1 Myosin head (motor domain) MyTH4 PF00784.15 T154513_1 - 1.8e-19 70.1 0.1 1.8e-19 70.1 0.1 2.4 3 0 0 3 3 3 1 MyTH4 domain TFIIA PF03153.11 T154513_1 - 6.5 6.5 18.0 11 5.7 18.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IQ PF00612.25 T154513_1 - 7.3 6.6 8.3 2.7 7.9 3.7 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif Myosin_head PF00063.19 T154513_2 - 7.5e-17 60.7 0.0 1.2e-10 40.2 0.0 2.0 2 0 0 2 2 2 2 Myosin head (motor domain) FERM_M PF00373.16 T154513_2 - 1.3e-06 28.7 0.0 2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 FERM central domain AAA_16 PF13191.4 T154513_2 - 0.017 15.3 0.0 0.037 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 T154513_2 - 0.025 14.7 0.1 0.048 13.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain MyTH4 PF00784.15 T154513_3 - 4.8e-26 91.2 0.0 1e-25 90.2 0.0 1.6 1 0 0 1 1 1 1 MyTH4 domain Myosin_head PF00063.19 T154513_3 - 1.9e-21 75.9 0.0 2.8e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) SH3_2 PF07653.15 T154513_3 - 5.2e-10 38.7 0.0 1.3e-09 37.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T154513_3 - 1.1e-07 31.4 0.0 1.8e-06 27.5 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain FERM_M PF00373.16 T154513_3 - 0.0034 17.6 0.0 0.008 16.4 0.0 1.6 1 0 0 1 1 1 1 FERM central domain fn3 PF00041.19 T203788_1 - 0 4176.4 247.2 4.7e-18 65.2 0.2 89.7 89 0 0 89 89 89 88 Fibronectin type III domain I-set PF07679.14 T203788_1 - 0 2266.1 74.4 7.2e-24 83.5 0.2 52.7 52 0 0 52 52 50 45 Immunoglobulin I-set domain Ig_3 PF13927.4 T203788_1 - 0 1353.9 24.7 2.3e-15 56.8 0.3 49.1 47 0 0 47 47 46 45 Immunoglobulin domain Ig_2 PF13895.4 T203788_1 - 6.8e-198 641.5 27.8 1.2e-09 38.3 0.1 45.6 45 0 0 45 45 45 36 Immunoglobulin domain ig PF00047.23 T203788_1 - 1.8e-189 614.4 59.1 6.7e-11 42.1 0.6 44.5 45 0 0 45 45 44 31 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 T203788_1 - 4.3e-121 395.7 201.6 0.008 16.6 0.0 79.1 84 2 0 84 84 81 24 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 T203788_1 - 1.3e-113 371.2 0.0 0.00075 19.5 0.0 62.4 70 0 0 70 70 69 11 Fibronectin type III domain Pkinase PF00069.23 T203788_1 - 9.8e-57 192.2 0.7 1.8e-56 191.3 0.7 1.5 1 0 0 1 1 1 1 Protein kinase domain V-set PF07686.15 T203788_1 - 3.5e-53 178.2 68.5 0.0044 17.0 0.0 38.5 37 6 0 37 37 37 10 Immunoglobulin V-set domain C2-set_2 PF08205.10 T203788_1 - 1.8e-52 175.2 52.5 0.11 12.4 0.1 36.2 40 0 0 40 40 38 9 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.6 T203788_1 - 3.8e-40 136.3 49.2 0.4 10.8 0.0 39.8 46 1 1 47 47 45 4 Natural killer cell receptor 2B4 fn3_4 PF16794.3 T203788_1 - 1.7e-39 133.7 0.0 0.53 10.1 0.0 34.0 40 0 0 40 40 31 3 Fibronectin-III type domain DUF2369 PF10179.7 T203788_1 - 1.1e-29 102.6 24.0 0.27 11.6 0.0 30.6 36 0 0 36 36 30 3 Uncharacterised conserved protein (DUF2369) Pkinase_Tyr PF07714.15 T203788_1 - 2e-27 96.0 0.3 3.4e-27 95.2 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Tissue_fac PF01108.15 T203788_1 - 2.4e-27 94.7 78.2 0.11 12.2 0.0 38.9 49 0 0 49 49 46 3 Tissue factor DUF11 PF01345.16 T203788_1 - 5.4e-16 58.6 68.3 0.65 10.2 0.0 25.2 28 2 0 28 28 23 4 Domain of unknown function DUF11 Y_Y_Y PF07495.11 T203788_1 - 1e-11 44.5 66.8 24 4.8 0.0 36.4 46 0 0 46 46 43 0 Y_Y_Y domain SusE PF14292.4 T203788_1 - 1.1e-10 41.8 82.3 15 5.9 0.0 33.7 42 1 3 45 45 33 0 SusE outer membrane protein BiPBP_C PF06832.10 T203788_1 - 5.6e-09 35.8 0.4 28 4.7 0.0 12.0 14 0 0 14 14 11 0 Penicillin-Binding Protein C-terminus Family CRISPR_assoc PF08798.9 T203788_1 - 0.00032 20.8 0.0 37 4.2 0.0 10.0 11 0 0 11 11 6 0 CRISPR associated protein PA14 PF07691.10 T203788_1 - 0.00057 19.6 8.4 14 5.3 0.0 12.5 14 0 0 14 14 11 0 PA14 domain C1-set PF07654.13 T203788_1 - 0.0041 17.4 27.3 0.19 12.1 0.0 11.4 13 0 0 13 13 10 1 Immunoglobulin C1-set domain DUF3954 PF13128.4 T203788_1 - 0.057 13.1 0.0 14 5.4 0.0 3.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3954) Izumo-Ig PF16706.3 T203788_1 - 0.57 10.1 40.4 7 6.6 0.0 16.2 22 0 0 22 22 13 0 Izumo-like Immunoglobulin domain Flagellin_D3 PF08884.9 T203788_1 - 7.9 6.8 15.8 0.087 13.1 1.6 5.5 6 0 0 6 6 3 0 Flagellin D3 domain PA14 PF07691.10 T071261_3 - 6.4e-31 107.0 0.0 1.1e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 PA14 domain CHGN PF05679.14 T071261_3 - 5.7e-25 88.0 0.0 1.3e-24 86.8 0.0 1.5 1 1 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.12 T071261_3 - 4.4e-11 42.1 0.4 4.4e-11 42.1 0.4 2.2 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase DUF2559 PF10832.6 T071261_3 - 0.036 14.0 0.3 0.086 12.8 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2559) DUF3844 PF12955.5 T207347_1 - 0.24 11.4 1.6 0.65 10.0 1.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) Thyroglobulin_1 PF00086.16 T207347_3 - 6.5e-18 64.0 2.5 1.3e-17 63.1 2.5 1.6 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat CD36 PF01130.19 T088835_2 - 9.9e-155 515.4 2.5 1.2e-154 515.2 2.5 1.1 1 0 0 1 1 1 1 CD36 family SH3_2 PF07653.15 T154489_1 - 5.2e-10 38.7 0.0 1.1e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T154489_1 - 1e-07 31.6 0.0 1.6e-06 27.7 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 T154489_1 - 0.13 11.8 0.0 1.7 8.2 0.0 2.4 2 0 0 2 2 2 0 SH3 domain Myosin_head PF00063.19 T154489_2 - 2.5e-139 465.4 0.0 3.2e-139 465.0 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.15 T154489_2 - 1e-46 157.7 7.5 8.8e-26 90.4 0.0 3.5 4 0 0 4 4 4 2 MyTH4 domain FERM_M PF00373.16 T154489_2 - 1.4e-15 57.6 0.3 6.4e-15 55.5 0.2 2.2 2 0 0 2 2 2 1 FERM central domain AAA_16 PF13191.4 T154489_2 - 0.00039 20.7 0.0 0.029 14.6 0.0 3.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 T154489_2 - 0.0084 16.3 0.0 0.031 14.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 T154489_2 - 0.077 13.0 0.0 0.28 11.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain IQ PF00612.25 T154489_2 - 0.7 9.7 3.7 2.3 8.1 3.7 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ala_racemase_N PF01168.18 T342117_3 - 1.6e-19 70.3 0.0 2.7e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Band_7 PF01145.23 T342117_3 - 3.5e-18 66.1 0.0 6.3e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Ceramidase_alk PF04734.11 T041959_2 - 4.5e-223 741.3 0.0 5.4e-223 741.1 0.0 1.1 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.3 T041959_2 - 1.2e-45 155.3 0.0 1.7e-45 154.8 0.0 1.2 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Transcrip_act PF04949.11 T024930_3 - 4.1e-07 29.9 18.6 9.5e-07 28.7 18.6 1.6 1 0 0 1 1 1 1 Transcriptional activator Pkinase PF00069.23 T052731_2 - 3.5e-71 239.5 0.0 4.7e-71 239.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T052731_2 - 9.1e-39 133.2 0.0 1.2e-38 132.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 T052731_2 - 0.00089 19.1 0.3 0.004 17.0 0.0 2.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.4 T052731_2 - 0.044 13.0 0.0 0.061 12.5 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.18 T052731_2 - 0.093 12.2 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.12 T052731_2 - 0.16 11.2 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Gag_p24 PF00607.18 T125552_1 - 4e-27 95.3 0.0 6.3e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) Gag_p10 PF02337.15 T125552_1 - 1.3e-22 79.3 0.3 2.6e-22 78.3 0.3 1.5 1 0 0 1 1 1 1 Retroviral GAG p10 protein dUTPase PF00692.17 T125552_1 - 7.4e-15 54.6 0.0 1.2e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 dUTPase RVP PF00077.18 T125552_1 - 1.4e-14 54.0 0.0 2.7e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_5 PF14787.4 T125552_1 - 6.5e-11 41.6 0.6 6.5e-11 41.6 0.6 2.8 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger HERV-K_REC PF15695.3 T125552_1 - 0.00039 20.3 0.1 0.00073 19.4 0.1 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 zf-CCHC_2 PF13696.4 T125552_1 - 2.5 7.9 7.4 2.2 8.0 3.0 3.2 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.25 T125552_2 - 4.8e-31 107.9 0.0 8.4e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.12 T125552_2 - 5.8e-28 96.3 0.0 1.1e-27 95.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase thumb domain rve PF00665.24 T125552_3 - 2e-19 69.8 0.0 3.7e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_Zn PF02022.17 T125552_3 - 4.4e-14 52.0 0.9 1e-13 50.8 0.9 1.7 1 0 0 1 1 1 1 Integrase Zinc binding domain RNase_H PF00075.22 T125552_3 - 7.2e-12 45.6 0.0 1.1e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p24 PF00607.18 T125552_3 - 1.4e-06 28.2 0.0 0.00024 20.9 0.0 2.2 2 0 0 2 2 2 2 gag gene protein p24 (core nucleocapsid protein) IN_DBD_C PF00552.19 T125552_3 - 1.9e-06 27.0 2.5 4e-06 25.9 2.5 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain G-patch PF01585.21 T125552_3 - 3.4e-05 23.5 0.1 7.3e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 G-patch domain RVP PF00077.18 T125552_3 - 0.0025 17.9 0.0 0.0048 17.0 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Arm PF00514.21 T229310_1 - 3e-39 131.8 7.9 2.5e-09 36.7 0.0 7.6 7 0 0 7 7 7 7 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 T229310_1 - 4.1e-12 46.2 12.1 0.00042 20.6 0.2 6.9 6 0 0 6 6 6 3 HEAT-like repeat HEAT PF02985.20 T229310_1 - 5e-08 32.4 11.0 0.022 14.8 0.1 5.3 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.4 T229310_1 - 3e-07 30.6 15.5 8.9e-05 22.7 1.1 4.0 4 1 1 5 5 5 3 HEAT repeats Atx10homo_assoc PF09759.7 T229310_1 - 0.005 16.8 0.1 0.043 13.8 0.0 2.4 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.11 T229310_1 - 0.019 14.3 0.0 1.3 8.3 0.0 2.8 3 1 0 3 3 3 0 Armadillo-like DUF3704 PF12488.6 T318084_1 - 0.26 10.8 2.1 0.59 9.7 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) EABR PF12180.6 T046282_3 - 2e-18 65.6 2.3 4.9e-18 64.3 2.3 1.7 1 0 0 1 1 1 1 TSG101 and ALIX binding domain of CEP55 Cep57_CLD_2 PF14197.4 T046282_3 - 0.008 16.1 7.0 0.008 16.1 7.0 4.7 3 2 1 4 4 4 1 Centrosome localisation domain of PPC89 zf-C2H2_3 PF13878.4 T046282_3 - 0.0088 15.7 0.2 0.018 14.7 0.2 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO CENP-F_leu_zip PF10473.7 T046282_3 - 3 7.7 69.2 0.28 11.1 9.0 4.4 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Thiolase_C PF02803.16 T240309_1 - 2.1e-48 162.9 0.1 3e-48 162.4 0.1 1.2 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.8 T240309_1 - 0.00023 21.1 0.0 0.0004 20.4 0.0 1.3 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Thiolase_N PF00108.21 T240309_1 - 0.064 12.5 0.1 0.093 11.9 0.1 1.2 1 0 0 1 1 1 0 Thiolase, N-terminal domain Thiolase_N PF00108.21 T240309_2 - 4.2e-76 255.6 0.3 6.1e-76 255.1 0.3 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Arm_2 PF04826.11 T302443_1 - 2.4e-21 76.2 0.4 3.5e-21 75.7 0.4 1.1 1 0 0 1 1 1 1 Armadillo-like HEAT_EZ PF13513.4 T302443_1 - 0.001 19.4 1.5 0.11 12.9 0.2 3.3 3 0 0 3 3 3 1 HEAT-like repeat Arm PF00514.21 T302443_1 - 0.0085 16.0 1.7 1.9 8.5 0.1 3.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT PF02985.20 T302443_1 - 0.085 13.0 0.4 16 5.9 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat zf-B_box PF00643.22 T002130_1 - 2.1e-08 34.0 7.8 9.9e-08 31.9 0.9 3.0 2 0 0 2 2 2 2 B-box zinc finger DUF3583 PF12126.6 T002130_1 - 8.6e-05 22.0 2.4 0.00014 21.3 2.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3583) IL10 PF00726.15 T002130_1 - 0.095 12.1 0.6 0.17 11.3 0.6 1.3 1 0 0 1 1 1 0 Interleukin 10 Tnp_zf-ribbon_2 PF13842.4 T002130_1 - 0.1 13.3 4.3 0.44 11.3 4.3 2.1 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon zf-C3HC4_4 PF15227.4 T002130_2 - 0.056 13.5 10.2 0.17 11.9 10.2 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING MAD PF05557.11 T002130_3 - 0.021 13.1 0.4 0.028 12.6 0.4 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein MRI PF15325.4 T333793_1 - 8.6e-50 168.2 0.8 1.4e-49 167.5 0.8 1.4 1 0 0 1 1 1 1 Modulator of retrovirus infection WD40 PF00400.30 T333793_1 - 1.5e-08 35.0 5.4 0.038 14.7 0.0 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T333793_1 - 1.3e-05 25.2 0.0 0.01 16.0 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 T333793_1 - 0.048 12.5 0.0 0.096 11.5 0.0 1.4 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GIT_CC PF16559.3 T333793_1 - 0.11 12.4 1.8 0.22 11.4 1.8 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor WD40 PF00400.30 T254096_1 - 1.1e-18 67.1 9.4 0.0011 19.5 0.0 8.6 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T254096_1 - 0.11 12.7 0.3 1.3 9.3 0.1 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Serpin PF00079.18 T254096_3 - 1.6e-110 369.8 7.7 2e-110 369.5 7.7 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) V-set PF07686.15 T112232_1 - 2.1e-14 53.4 0.1 2.6e-14 53.2 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T112232_1 - 0.02 15.3 0.2 0.086 13.3 0.2 1.9 1 1 0 1 1 1 0 Immunoglobulin domain Neurokinin_B PF03823.12 T112232_1 - 0.067 13.1 0.2 0.11 12.4 0.2 1.3 1 0 0 1 1 1 0 Neurokinin B EF-hand_4 PF12763.5 T146279_1 - 0.056 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DEAD PF00270.27 T146279_2 - 2.7e-36 124.9 0.0 3.9e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T146279_2 - 4.3e-29 101.0 0.1 1.2e-28 99.5 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 T146279_2 - 0.00031 20.6 0.0 0.00068 19.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 T146279_2 - 0.014 15.6 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain CK1gamma_C PF12605.6 T146279_2 - 0.18 12.9 0.6 0.45 11.6 0.6 1.6 1 0 0 1 1 1 0 Casein kinase 1 gamma C terminal Bim_N PF06773.9 T196717_1 - 1.1e-18 66.4 8.0 3.7e-18 64.8 8.0 2.0 1 0 0 1 1 1 1 Bim protein N-terminus Bclx_interact PF08945.8 T196717_1 - 5.2e-17 61.2 1.0 1.2e-16 60.1 1.0 1.5 1 0 0 1 1 1 1 Bcl-x interacting, BH3 domain ACOX PF01756.17 T196717_3 - 4.2e-17 62.2 0.9 7.5e-17 61.4 0.2 1.7 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.17 T196717_3 - 1.6e-13 50.5 0.0 2.6e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.22 T196717_3 - 1.3e-05 25.3 0.7 2.3e-05 24.5 0.7 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain zf-H2C2_5 PF13909.4 T261239_1 - 6.4e-06 25.7 17.7 2.9e-05 23.6 0.9 3.9 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.4 T261239_1 - 4.1e-05 23.7 0.2 4.1e-05 23.7 0.2 4.4 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.24 T261239_1 - 0.21 12.0 33.0 1.5 9.3 0.3 5.8 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T261239_1 - 1.3 9.9 21.5 2.3 9.1 2.1 5.4 4 0 0 4 4 4 0 C2H2-type zinc finger DUF3664 PF12406.6 T261239_1 - 3.2 8.3 5.5 4.6 7.8 0.6 2.4 2 0 0 2 2 2 0 Surface protein PLDc_N PF13396.4 T261239_2 - 2.1 8.2 7.7 0.72 9.7 0.6 2.9 3 0 0 3 3 3 0 Phospholipase_D-nuclease N-terminal CUB PF00431.18 T072849_1 - 1e-47 160.9 0.0 1.1e-27 96.4 0.0 2.3 2 0 0 2 2 2 2 CUB domain FXa_inhibition PF14670.4 T072849_1 - 8.5e-10 38.6 6.4 8.5e-10 38.6 6.4 3.2 4 0 0 4 4 4 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 T072849_1 - 1.4e-05 25.0 6.2 1.4e-05 25.0 6.2 2.3 2 0 0 2 2 2 1 Calcium-binding EGF domain cEGF PF12662.5 T072849_1 - 7e-05 22.5 8.7 0.0001 22.0 3.4 3.0 2 0 0 2 2 2 1 Complement Clr-like EGF-like Sushi PF00084.18 T072849_1 - 0.00037 20.9 0.4 0.00037 20.9 0.4 3.0 3 0 0 3 3 3 1 Sushi repeat (SCR repeat) PMBR PF09373.8 T072849_1 - 0.072 13.1 0.1 0.18 11.9 0.1 1.7 1 0 0 1 1 1 0 Pseudomurein-binding repeat Trypsin PF00089.24 T072849_2 - 6.6e-44 150.2 0.0 9.6e-44 149.7 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 T072849_2 - 5.7e-10 39.4 0.0 1.1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 CUB domain Trypsin PF00089.24 T072849_3 - 2e-48 165.0 0.0 2.8e-48 164.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 T072849_3 - 0.053 14.3 0.0 0.14 12.9 0.0 1.7 1 1 0 1 1 1 0 Trypsin-like peptidase domain Caldesmon PF02029.13 T027817_1 - 3.7e-14 52.3 35.6 4.1e-08 32.3 1.8 2.1 2 0 0 2 2 2 2 Caldesmon Troponin PF00992.18 T027817_2 - 3.9e-33 114.5 50.3 7.8e-31 107.0 36.6 3.2 2 1 1 3 3 3 2 Troponin Aminotran_1_2 PF00155.19 T233454_2 - 1.2e-65 222.0 0.0 1.6e-65 221.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Linker_histone PF00538.17 T233454_2 - 5.6e-27 93.8 1.3 1.4e-26 92.5 1.3 1.7 1 0 0 1 1 1 1 linker histone H1 and H5 family Aminotran_5 PF00266.17 T233454_2 - 0.00041 19.3 0.0 0.00065 18.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Forkhead PF00250.16 T233454_2 - 0.022 14.9 0.0 0.044 14.0 0.0 1.4 1 0 0 1 1 1 0 Forkhead domain Cys_Met_Meta_PP PF01053.18 T233454_2 - 0.029 12.7 0.0 0.047 12.1 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.19 T233454_2 - 0.12 11.6 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase zf-H2C2_2 PF13465.4 T034757_3 - 2e-53 176.4 81.5 1.5e-08 34.5 1.3 11.5 10 1 0 10 10 10 9 Zinc-finger double domain KRAB PF01352.25 T034757_3 - 9.3e-25 85.9 0.1 2e-24 84.8 0.1 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2 PF00096.24 T034757_3 - 6.4e-20 70.3 91.1 3.1e-05 24.0 2.7 10.3 11 0 0 11 11 11 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T034757_3 - 1e-19 69.4 67.4 0.0028 18.2 2.1 10.4 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T034757_3 - 0.0018 18.1 73.3 0.028 14.3 0.6 9.2 10 0 0 10 10 10 7 C2H2-type zinc finger DAGK_acc PF00609.17 T256410_1 - 8.1e-57 191.9 0.0 1.2e-56 191.4 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 T256410_1 - 5e-18 64.8 0.4 8.8e-16 57.5 0.1 2.3 1 1 1 2 2 2 2 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 T256410_1 - 0.0005 19.8 14.4 0.0014 18.3 14.4 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4187 PF13821.4 T256410_1 - 0.13 11.9 1.0 0.27 10.9 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) DAG_kinase_N PF14513.4 T256410_3 - 2e-52 177.7 0.1 2.9e-52 177.1 0.1 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus C1_1 PF00130.20 T256410_3 - 1e-09 38.0 11.2 3.2e-09 36.4 11.2 2.0 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.30 T256410_3 - 5.1e-07 28.7 1.0 0.014 14.8 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 T256410_3 - 1.3e-06 28.7 0.3 2.4e-06 27.8 0.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T256410_3 - 0.00035 20.1 0.1 0.4 10.6 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 T256410_3 - 0.018 14.4 0.4 0.17 11.3 0.0 2.5 2 0 0 2 2 2 0 EF hand EGF PF00008.25 T019255_2 - 1.3e-28 98.7 81.5 3e-07 30.5 5.3 7.2 6 0 0 6 6 6 6 EGF-like domain EGF_CA PF07645.13 T019255_2 - 7.6e-08 32.3 6.2 7.6e-08 32.3 6.2 6.4 3 1 3 6 6 6 1 Calcium-binding EGF domain hEGF PF12661.5 T019255_2 - 8e-06 26.2 90.8 1.4e-05 25.4 6.4 8.8 7 1 0 7 7 7 5 Human growth factor-like EGF DUF1220 PF06758.11 T019255_3 - 1.9e-159 518.0 79.8 1.1e-26 92.8 7.2 8.0 8 0 0 8 8 8 7 Repeat of unknown function (DUF1220) GAT PF03127.12 T019255_3 - 0.00071 19.7 8.5 0.11 12.7 1.0 2.6 2 0 0 2 2 2 2 GAT domain Ion_trans PF00520.29 T202270_3 - 7e-257 847.3 103.8 1.7e-82 276.2 13.9 4.3 4 0 0 4 4 4 4 Ion transport protein Na_trans_cytopl PF11933.6 T202270_3 - 6.1e-66 222.2 17.2 7e-65 218.7 17.2 2.5 1 1 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.11 T202270_3 - 1.1e-55 188.7 1.9 1.1e-55 188.7 1.9 2.8 3 1 0 3 3 3 1 Sodium ion transport-associated PKD_channel PF08016.10 T202270_3 - 4.6e-06 25.4 82.6 0.00019 20.1 0.3 9.5 6 4 4 10 10 10 5 Polycystin cation channel GPHH PF16905.3 T202270_3 - 1.2e-05 24.9 0.0 2.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated ATP-synt_B PF00430.16 T202270_3 - 0.0013 18.7 5.2 0.005 16.8 5.2 2.0 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) Tmemb_9 PF05434.9 T202270_3 - 0.091 12.5 1.6 20 4.9 0.1 3.2 2 0 0 2 2 2 0 TMEM9 BRICHOS PF04089.12 T377596_3 - 1.2e-16 60.4 0.0 2.4e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain MFS_2 PF13347.4 T377596_3 - 0.051 12.0 0.1 0.086 11.2 0.1 1.3 1 0 0 1 1 1 0 MFS/sugar transport protein RIB43A PF05914.10 T377596_3 - 0.097 11.3 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 RIB43A KH_1 PF00013.27 T013605_1 - 2e-67 222.8 14.9 8.3e-18 63.8 0.1 4.2 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 T013605_1 - 6.9e-21 73.7 9.2 1.4e-05 24.7 0.0 4.3 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.8 T013605_1 - 1.8e-11 43.2 19.5 4.2e-07 29.2 3.7 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF1897) KH_4 PF13083.4 T013605_1 - 1.7e-06 27.6 11.0 0.15 11.9 0.1 4.2 4 0 0 4 4 4 3 KH domain Secretin_N PF03958.15 T013605_1 - 0.017 15.3 0.4 0.35 11.2 0.3 2.6 2 1 0 2 2 2 0 Bacterial type II/III secretion system short domain KH_5 PF13184.4 T013605_1 - 0.98 9.4 9.9 18 5.4 0.1 4.0 4 0 0 4 4 4 0 NusA-like KH domain zf-C2H2_6 PF13912.4 T303704_3 - 8.3e-15 54.2 5.9 9.1e-05 22.2 0.2 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_4 PF13894.4 T303704_3 - 8.5e-09 35.4 10.8 0.061 14.1 0.1 5.2 4 0 0 4 4 4 3 C2H2-type zinc finger ELM2 PF01448.22 T303704_3 - 1.7e-06 28.5 0.0 1.7e-06 28.5 0.0 3.0 3 0 0 3 3 3 1 ELM2 domain zf-C2H2 PF00096.24 T303704_3 - 6e-06 26.3 19.8 0.062 13.7 1.2 5.8 5 0 0 5 5 5 3 Zinc finger, C2H2 type Myb_DNA-binding PF00249.29 T303704_3 - 0.0013 18.7 0.1 0.0029 17.6 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-CW PF07496.13 T303704_3 - 0.0058 16.5 0.3 0.016 15.1 0.3 1.8 1 0 0 1 1 1 1 CW-type Zinc Finger zf-C2H2_jaz PF12171.6 T303704_3 - 0.01 16.0 1.7 2.9 8.2 0.7 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 T303704_3 - 0.03 14.5 8.7 0.092 13.0 0.0 3.5 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) Sigma70_ner PF04546.11 T303704_3 - 0.067 12.9 2.1 0.15 11.8 2.1 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region Myb_DNA-bind_7 PF15963.3 T303704_3 - 0.98 9.2 4.9 0.11 12.2 0.2 1.8 2 0 0 2 2 2 0 Myb DNA-binding like Mob1_phocein PF03637.15 T052754_3 - 2.6e-57 193.4 4.2 3.5e-57 193.0 4.2 1.1 1 0 0 1 1 1 1 Mob1/phocein family Scramblase PF03803.13 T140946_1 - 7.9e-46 156.0 0.0 1.1e-45 155.6 0.0 1.1 1 0 0 1 1 1 1 Scramblase PWWP PF00855.15 T200684_3 - 7.6e-06 26.2 0.0 1.9e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 PWWP domain MBD PF01429.17 T200684_3 - 0.11 12.0 0.0 0.33 10.6 0.0 1.7 1 0 0 1 1 1 0 Methyl-CpG binding domain SEA PF01390.18 T248024_3 - 2.3e-20 72.7 0.2 3.8e-20 72.0 0.2 1.4 1 0 0 1 1 1 1 SEA domain Copine PF07002.14 T302676_1 - 1.1e-90 302.7 0.0 1.5e-90 302.3 0.0 1.1 1 0 0 1 1 1 1 Copine C2 PF00168.28 T302676_1 - 5.1e-30 103.7 0.1 5.2e-14 52.3 0.0 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 T302676_1 - 2.8e-06 27.5 0.0 4.6e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VCBS PF13517.4 T302676_1 - 0.078 13.5 0.2 0.18 12.3 0.2 1.6 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 7tm_4 PF13853.4 T034964_3 - 1.9e-50 172.0 18.8 3.1e-50 171.3 18.8 1.3 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T034964_3 - 1.2e-15 57.4 24.8 2.8e-15 56.1 24.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-TRAF_2 PF15965.3 T199128_3 - 0.0046 17.3 1.4 0.0094 16.3 1.4 1.5 1 0 0 1 1 1 1 TRAF-like zinc-finger EF-hand_8 PF13833.4 T339598_1 - 0.0032 17.1 0.7 0.017 14.8 0.5 2.1 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.4 T339598_1 - 0.0089 16.3 0.3 0.036 14.4 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 T339598_1 - 0.012 15.0 0.6 0.031 13.7 0.6 1.7 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.4 T339598_1 - 0.029 14.2 0.3 0.077 12.8 0.3 1.7 1 0 0 1 1 1 0 EF-hand domain SMK-1 PF04802.13 T339598_3 - 1.2e-08 35.0 0.0 2.7e-08 33.8 0.0 1.5 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 EF-hand_8 PF13833.4 T339598_3 - 4.5e-08 32.6 2.2 9.5e-08 31.6 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.4 T339598_3 - 0.00027 21.2 1.6 0.00064 20.0 0.3 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 T339598_3 - 0.00082 18.6 0.9 0.00082 18.6 0.9 2.9 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 T339598_3 - 0.0013 18.3 2.8 0.0026 17.4 0.5 2.7 3 0 0 3 3 3 1 EF-hand domain Katanin_con80 PF13925.4 T133279_3 - 3.7e-55 186.2 0.5 6.6e-55 185.4 0.5 1.4 1 0 0 1 1 1 1 con80 domain of Katanin WD40 PF00400.30 T133279_3 - 9.8e-46 152.7 5.0 4e-11 43.1 0.2 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T133279_3 - 1.8e-15 56.9 0.0 0.00012 22.2 0.0 5.2 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Pro_racemase PF05544.9 T105282_2 - 8e-115 383.2 0.9 9.1e-62 208.8 0.2 2.1 2 0 0 2 2 2 2 Proline racemase 7tm_1 PF00001.19 T105282_3 - 6e-39 133.7 6.6 9.6e-39 133.1 6.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.19 T006497_3 - 7.3e-40 136.8 20.5 1e-39 136.3 20.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SHNi-TPR PF10516.7 T006497_3 - 0.063 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 SHNi-TPR DUF2516 PF10724.7 T006497_3 - 4.1 7.6 7.8 8.5 6.6 2.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2516) 7tm_1 PF00001.19 T321775_1 - 5.4e-07 29.0 32.3 5.4e-07 29.0 32.3 3.3 3 1 0 3 3 3 1 7 transmembrane receptor (rhodopsin family) IRS PF02174.15 T163679_1 - 1.1e-28 98.9 0.0 1.9e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.27 T163679_1 - 0.00066 20.0 0.8 0.0011 19.3 0.8 1.4 1 0 0 1 1 1 1 PH domain TCL1_MTCP1 PF01840.15 T109717_1 - 7.8e-34 115.6 0.2 1.4e-33 114.8 0.2 1.4 1 0 0 1 1 1 1 TCL1/MTCP1 family 7tm_2 PF00002.22 T337362_3 - 4.7e-83 278.1 12.8 6.2e-83 277.7 12.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 T337362_3 - 6.7e-22 77.4 4.8 6.7e-22 77.4 4.8 2.5 2 0 0 2 2 2 1 Hormone receptor domain Abi PF02517.14 T061807_1 - 5.4e-08 33.0 1.3 1.1e-07 32.0 1.3 1.5 1 0 0 1 1 1 1 CAAX protease self-immunity DUF4554 PF15091.4 T061807_2 - 2.1e-269 893.8 0.6 2.8e-269 893.4 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4554) Sulfate_transp PF00916.18 T242199_1 - 8.9e-20 70.6 2.1 1.2e-19 70.2 2.1 1.1 1 0 0 1 1 1 1 Sulfate permease family Sulfate_transp PF00916.18 T242199_2 - 1.2e-79 267.7 10.6 1.8e-79 267.1 10.6 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 T242199_2 - 8.7e-21 73.6 0.1 1.5e-20 72.8 0.1 1.4 1 0 0 1 1 1 1 STAS domain 7tm_2 PF00002.22 T242199_2 - 0.19 10.9 4.0 0.099 11.8 0.2 2.0 2 0 0 2 2 2 0 7 transmembrane receptor (Secretin family) Carn_acyltransf PF00755.18 T236571_1 - 3.1e-193 643.5 0.0 3.8e-193 643.2 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Choline_kinase PF01633.18 T236571_1 - 1.1e-65 221.0 0.0 1.9e-65 220.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase CPT_N PF16484.3 T236571_1 - 3.7e-26 90.7 0.1 7.5e-26 89.7 0.1 1.6 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus APH PF01636.21 T236571_1 - 6.4e-10 39.2 0.0 1.7e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.18 T236571_1 - 0.0013 18.0 0.0 0.0029 16.8 0.0 1.5 1 1 0 1 1 1 1 Ecdysteroid kinase ABC_tran PF00005.25 T153226_1 - 1.2e-29 103.4 0.5 5.6e-20 72.1 0.1 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 T153226_1 - 8.3e-06 25.7 2.1 9.6e-06 25.5 0.1 1.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.25 T153226_3 - 4e-71 237.8 0.6 9.7e-29 100.5 0.0 4.3 4 0 0 4 4 4 3 ABC transporter ABC2_membrane_3 PF12698.5 T153226_3 - 1.1e-61 208.7 103.6 3.9e-29 101.7 30.7 3.4 3 0 0 3 3 3 3 ABC-2 family transporter protein AAA_21 PF13304.4 T153226_3 - 1.2e-23 84.2 2.3 0.0024 17.6 0.0 6.5 6 0 0 6 6 6 5 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 T153226_3 - 2e-14 53.7 0.3 0.00056 19.7 0.0 3.3 3 0 0 3 3 3 3 Protein of unknown function, DUF258 AAA_29 PF13555.4 T153226_3 - 6.2e-12 44.9 2.9 0.0033 17.0 0.1 3.4 3 0 0 3 3 3 3 P-loop containing region of AAA domain AAA_23 PF13476.4 T153226_3 - 6.1e-09 36.5 13.5 0.0045 17.4 0.1 4.1 4 0 0 4 4 4 3 AAA domain MMR_HSR1 PF01926.21 T153226_3 - 2.1e-07 30.9 2.0 0.74 9.8 0.0 3.7 3 0 0 3 3 3 3 50S ribosome-binding GTPase AAA_16 PF13191.4 T153226_3 - 1.2e-05 25.6 0.0 0.83 9.9 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_15 PF13175.4 T153226_3 - 4.6e-05 23.1 13.0 0.8 9.1 0.0 5.4 6 0 0 6 6 5 2 AAA ATPase domain DUF4162 PF13732.4 T153226_3 - 6.3e-05 23.5 0.4 7.6 7.2 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4162) AAA_25 PF13481.4 T153226_3 - 0.00012 21.6 0.0 0.12 11.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain SMC_N PF02463.17 T153226_3 - 0.00027 20.3 4.6 1.9 7.7 0.1 4.8 4 1 0 4 4 4 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.4 T153226_3 - 0.0016 18.5 0.0 0.68 10.1 0.0 3.6 3 1 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.4 T153226_3 - 0.0049 16.5 0.2 15 5.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.21 T153226_3 - 0.0053 16.7 2.5 6.8 6.6 0.2 3.6 3 1 0 3 3 3 1 Dynamin family AAA_22 PF13401.4 T153226_3 - 0.011 15.9 2.4 7.1 6.8 0.2 3.4 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.20 T153226_3 - 0.016 15.5 1.3 23 5.3 0.0 3.5 3 0 0 3 3 3 0 RNA helicase IstB_IS21 PF01695.15 T153226_3 - 0.03 13.9 0.1 4.8 6.8 0.0 3.6 3 0 0 3 3 3 0 IstB-like ATP binding protein ATP-synt_ab PF00006.23 T153226_3 - 0.072 12.6 0.1 19 4.7 0.0 2.8 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_27 PF13514.4 T153226_3 - 0.11 11.9 0.2 5.2 6.5 0.1 2.5 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.16 T153226_3 - 0.25 10.7 1.5 24 4.3 0.1 3.0 3 0 0 3 3 3 0 Ferrous iron transport protein B cobW PF02492.17 T153226_3 - 0.26 10.7 4.1 11 5.4 0.0 3.4 4 0 0 4 4 3 0 CobW/HypB/UreG, nucleotide-binding domain DUF2524 PF10732.7 T153226_3 - 0.53 10.5 2.7 5.7 7.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) CALCOCO1 PF07888.9 T079443_1 - 1.8e-224 746.8 37.9 2.3e-224 746.4 37.9 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Vps23_core PF09454.8 T079443_1 - 0.02 14.7 1.3 0.063 13.1 1.3 1.8 1 0 0 1 1 1 0 Vps23 core domain Pox_A8 PF04745.10 T079443_1 - 0.11 11.5 0.3 0.16 10.8 0.3 1.2 1 0 0 1 1 1 0 VITF-3 subunit protein Pox_A_type_inc PF04508.10 T079443_1 - 0.19 11.5 0.1 0.19 11.5 0.1 3.5 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Reo_sigmaC PF04582.10 T079443_1 - 1.2 8.3 16.6 0.042 13.1 3.3 3.3 1 1 1 3 3 3 0 Reovirus sigma C capsid protein APG6 PF04111.10 T079443_1 - 6.1 6.0 69.2 0.29 10.4 8.6 3.6 1 1 3 4 4 4 0 Autophagy protein Apg6 CALCOCO1 PF07888.9 T079443_2 - 1.7e-12 46.7 1.2 2.3e-12 46.2 1.2 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Lectin_C PF00059.19 T073853_3 - 1.1e-07 32.4 0.5 9.1e-07 29.5 0.2 2.2 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 T073853_3 - 0.0016 18.0 0.1 0.0027 17.3 0.1 1.3 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like I-set PF07679.14 T162828_2 - 2.8e-13 49.6 0.0 5.8e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T162828_2 - 7.6e-11 42.3 0.0 4.7e-10 39.8 0.0 2.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T162828_2 - 6.1e-07 29.6 1.6 1.2e-06 28.6 0.3 2.2 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 T162828_2 - 9.1e-05 22.4 0.2 0.00096 19.2 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 T162828_2 - 0.0026 17.6 0.0 0.01 15.8 0.0 2.0 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain AMP-binding PF00501.26 T228386_2 - 1.2e-88 297.4 1.2 4.1e-50 170.5 0.5 3.2 3 0 0 3 3 3 3 AMP-binding enzyme DMAP_binding PF06464.9 T228386_2 - 8.5e-35 119.8 1.0 1.4e-34 119.1 1.0 1.4 1 0 0 1 1 1 1 DMAP1-binding Domain Transposase_22 PF02994.12 T228386_2 - 3e-06 26.2 0.3 4.7e-06 25.6 0.3 1.1 1 0 0 1 1 1 1 L1 transposable element GvpG PF05120.10 T228386_2 - 0.015 15.1 0.1 0.027 14.3 0.1 1.3 1 0 0 1 1 1 0 Gas vesicle protein G PACT_coil_coil PF10495.7 T228386_3 - 7.6e-24 84.0 0.2 7.6e-24 84.0 0.2 4.3 4 0 0 4 4 4 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Churchill PF06573.9 T105956_3 - 2.8e-53 178.8 3.6 4.2e-53 178.3 3.6 1.3 1 0 0 1 1 1 1 Churchill protein zf-RRPl_C4 PF17026.3 T105956_3 - 1.4 8.9 7.0 11 6.1 0.8 2.3 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type FAM183 PF14886.4 T009311_3 - 1.8e-25 89.5 0.2 3.4e-25 88.7 0.2 1.5 1 0 0 1 1 1 1 FAM183A and FAM183B related HPIP PF15226.4 T009311_3 - 0.078 13.3 0.5 0.17 12.2 0.5 1.5 1 0 0 1 1 1 0 HCF-1 beta-propeller-interacting protein family Myb_DNA-binding PF00249.29 T029884_1 - 6.5e-06 26.1 0.1 5.9e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 T029884_1 - 0.12 12.1 2.0 0.2 11.4 0.2 2.1 2 0 0 2 2 2 0 Myb DNA-binding like ELM2 PF01448.22 T029884_2 - 1.8e-07 31.7 0.0 3.1e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 ELM2 domain SRF-TF PF00319.16 T022511_1 - 6.7e-24 83.0 0.4 1.3e-23 82.1 0.4 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 T022511_1 - 1.1e-07 31.6 0.0 1.1e-07 31.6 0.0 2.8 2 1 0 2 2 2 1 Holliday junction regulator protein family C-terminal repeat DUF2360 PF10152.7 T022511_1 - 0.13 12.5 3.3 0.22 11.8 3.3 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) TFIIA PF03153.11 T022511_1 - 2.5 7.9 14.8 3.6 7.4 14.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.11 T022511_1 - 3.7 8.1 15.2 9.4 6.8 15.2 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase PF00069.23 T368251_3 - 9.4e-24 84.0 0.8 2.3e-23 82.8 0.1 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 T368251_3 - 7.4e-15 54.8 0.0 1.1e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T368251_3 - 0.026 13.7 0.0 0.036 13.3 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Ank_4 PF13637.4 T031370_3 - 6.6e-17 61.5 0.2 2.1e-13 50.4 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 T031370_3 - 7.5e-17 61.6 0.0 1.5e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 T031370_3 - 3.8e-13 49.1 0.0 1.4e-05 25.2 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 T031370_3 - 1.7e-12 46.2 0.0 0.00013 22.0 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat SH3_1 PF00018.26 T031370_3 - 7.3e-12 44.6 1.8 1.6e-11 43.5 1.6 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 T031370_3 - 2.8e-10 39.7 0.3 6.7e-10 38.5 0.3 1.6 1 0 0 1 1 1 1 Variant SH3 domain Ank_5 PF13857.4 T031370_3 - 6.7e-09 35.7 0.3 3.1e-07 30.4 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_2 PF07653.15 T031370_3 - 1.2e-06 28.0 0.1 3.7e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain Vinculin PF01044.17 T043031_1 - 4e-58 197.4 8.7 2.9e-43 148.2 2.4 2.7 2 1 0 2 2 2 2 Vinculin family HisKA PF00512.23 T043031_1 - 6.9 6.7 6.7 18 5.3 1.5 3.3 2 2 0 2 2 2 0 His Kinase A (phospho-acceptor) domain Kazal_1 PF00050.19 T265187_2 - 3.7e-18 65.1 3.9 5.5e-18 64.6 3.9 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 T265187_2 - 2.8e-09 36.9 1.6 4.2e-09 36.3 1.6 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain zf-RING_UBOX PF13445.4 T053819_2 - 6.6e-12 45.1 4.2 7.5e-12 44.9 2.5 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 T053819_2 - 7e-11 42.0 7.6 2.4e-10 40.3 7.6 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 T053819_2 - 1.1e-09 38.3 0.2 2.2e-09 37.4 0.2 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 T053819_2 - 3.4e-09 36.3 5.5 9.1e-09 34.9 5.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 T053819_2 - 9.6e-09 35.1 2.1 9.6e-09 35.1 2.1 3.1 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_2 PF13923.4 T053819_2 - 5.9e-08 32.3 6.5 4.4e-07 29.5 7.1 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T053819_2 - 9.7e-07 28.8 6.5 3.5e-06 27.0 6.5 2.1 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 T053819_2 - 3e-06 26.9 5.3 3e-06 26.9 5.3 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 T053819_2 - 1.5e-05 24.6 4.4 1.5e-05 24.6 4.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 T053819_2 - 6.1e-05 22.4 0.1 0.00014 21.2 0.1 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-RING_10 PF16685.3 T053819_2 - 0.0097 15.9 2.4 0.033 14.2 2.4 2.0 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-Nse PF11789.6 T053819_2 - 0.024 14.3 3.2 0.052 13.2 3.2 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FAM76 PF16046.3 T053819_2 - 0.072 12.3 5.9 0.19 10.9 5.9 1.6 1 1 0 1 1 1 0 FAM76 protein zf-UDP PF14569.4 T053819_2 - 0.089 12.8 0.6 0.23 11.5 0.6 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.4 T053819_2 - 0.71 9.7 11.3 0.13 12.0 6.7 2.2 2 1 0 2 2 1 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.4 T053819_2 - 1 9.1 7.0 0.12 12.2 2.1 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.5 T053819_2 - 9.2 6.5 8.3 0.43 10.8 2.1 2.1 2 0 0 2 2 1 0 RING-H2 zinc finger domain Helicase_C PF00271.29 T219462_1 - 0.028 14.7 0.0 0.044 14.0 0.0 1.3 1 0 0 1 1 1 0 Helicase conserved C-terminal domain DEAD PF00270.27 T219462_2 - 2.5e-37 128.2 1.2 3.7e-32 111.4 0.0 2.8 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.29 T219462_2 - 1.2e-18 67.4 0.1 5.2e-17 62.1 0.2 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 T219462_2 - 0.0011 18.9 0.0 0.0011 18.9 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UTP25 PF06862.10 T219462_2 - 0.011 14.5 0.2 0.14 10.8 0.0 2.6 3 1 0 3 3 3 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 bZIP_1 PF00170.19 T166460_1 - 1.6e-11 44.0 15.0 3.5e-11 42.9 14.6 1.8 1 1 1 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.13 T166460_1 - 5.5e-08 32.6 10.0 5.5e-08 32.6 10.0 2.1 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.15 T166460_1 - 0.0019 18.6 11.4 0.0019 18.6 11.4 3.0 3 0 0 3 3 3 1 bZIP Maf transcription factor IncA PF04156.12 T166460_1 - 1.5 8.4 10.7 0.12 12.0 4.6 2.1 2 0 0 2 2 2 0 IncA protein SOGA PF11365.6 T166460_1 - 2.1 9.4 8.9 5.8 8.0 8.9 1.7 1 0 0 1 1 1 0 Protein SOGA Uteroglobin PF01099.15 T290967_2 - 5.3e-05 23.2 0.0 8.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Uteroglobin family C2 PF00168.28 T068583_2 - 0.0045 17.1 0.0 0.0078 16.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain SR-25 PF10500.7 T088236_2 - 1.2e-101 339.0 48.8 1.7e-101 338.5 48.8 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.7 T088236_2 - 0.96 7.8 21.4 1.5 7.2 21.4 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF2353 PF09789.7 T048159_3 - 0.00048 19.5 7.3 0.00065 19.1 7.3 1.1 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) DUF106 PF01956.14 T048159_3 - 0.27 10.8 4.3 0.43 10.2 4.3 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF106 Radical_SAM_N PF08497.8 T048159_3 - 0.38 9.8 1.4 0.52 9.4 1.4 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal GrpE PF01025.17 T048159_3 - 0.51 9.9 7.7 0.77 9.3 7.7 1.2 1 0 0 1 1 1 0 GrpE XkdW PF09636.8 T048159_3 - 0.96 9.4 5.3 1.4 8.9 4.4 1.7 1 1 1 2 2 2 0 XkdW protein Exonuc_VII_L PF02601.13 T048159_3 - 1.1 8.6 3.1 1.5 8.2 3.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit MPS2 PF17060.3 T048159_3 - 6.9 5.7 8.4 9.3 5.3 8.4 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 AT_hook PF02178.17 T068481_1 - 0.72 9.8 11.4 0.47 10.4 3.1 3.7 2 0 0 2 2 2 0 AT hook motif BCL9 PF11502.6 T068481_2 - 2.3e-15 55.9 1.3 1e-14 53.9 1.3 2.2 1 0 0 1 1 1 1 B-cell lymphoma 9 protein RA PF00788.21 T075578_1 - 1.6e-07 31.7 0.0 3e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SWI-SNF_Ssr4 PF08549.8 T075578_1 - 0.02 13.5 13.6 0.029 12.9 13.6 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) TBPIP PF07106.11 T075578_1 - 0.36 10.5 40.7 0.015 14.9 11.3 3.1 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) tRNA-synt_1c PF00749.19 T030773_1 - 1.7e-125 417.9 0.3 2.9e-125 417.2 0.3 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain WHEP-TRS PF00458.18 T030773_1 - 2.1e-65 216.6 20.8 6.5e-24 83.7 2.6 4.1 3 0 0 3 3 3 3 WHEP-TRS domain tRNA-synt_1c_C PF03950.16 T030773_1 - 2.1e-39 135.0 0.0 6.3e-39 133.5 0.0 1.9 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain ProRS-C_1 PF09180.9 T030773_1 - 2.9e-21 75.3 0.2 7.5e-21 74.0 0.2 1.8 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.18 T030773_1 - 1.4e-17 63.5 0.9 6.1e-17 61.4 0.0 2.6 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.23 T030773_1 - 1.8e-17 63.8 0.1 1.8e-16 60.5 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) GST_C PF00043.23 T030773_1 - 9e-05 22.5 1.7 0.0002 21.4 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 T030773_1 - 0.001 19.1 0.1 0.0088 16.1 0.0 2.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.17 T030773_1 - 0.02 14.1 0.4 0.042 13.1 0.4 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain RRM_1 PF00076.20 T128456_3 - 8e-08 31.9 0.0 0.0042 16.7 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.22 T128456_3 - 1.4e-07 32.1 0.0 3.9e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 Exonuclease SCP-1 PF05483.10 T017804_1 - 0 1083.1 85.9 0 1082.8 85.9 1.0 1 0 0 1 1 1 1 Synaptonemal complex protein 1 (SCP-1) SCP-1 PF05483.10 T017804_2 - 7.7e-116 387.9 54.9 1.2e-115 387.2 54.9 1.2 1 0 0 1 1 1 1 Synaptonemal complex protein 1 (SCP-1) COX6B PF02297.15 T181272_2 - 3.3e-16 59.1 2.1 6.2e-16 58.3 2.1 1.4 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb ACTH_domain PF00976.16 T186262_1 - 8.7e-25 86.0 31.1 1.1e-10 41.0 4.4 3.5 3 0 0 3 3 3 3 Corticotropin ACTH domain NPP PF08384.8 T186262_1 - 1.9e-22 78.9 3.0 3.2e-22 78.2 3.0 1.4 1 0 0 1 1 1 1 Pro-opiomelanocortin, N-terminal region Op_neuropeptide PF08035.9 T186262_1 - 3.2e-16 58.7 0.1 5.5e-16 58.0 0.1 1.4 1 0 0 1 1 1 1 Opioids neuropeptide ACTH_assoc PF16102.3 T186262_1 - 0.0023 18.4 0.5 0.0023 18.4 0.5 2.8 3 0 0 3 3 3 1 ACTH-associated domain Pkinase PF00069.23 T342984_1 - 9.3e-40 136.5 0.0 1.6e-39 135.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T342984_1 - 2.5e-26 92.4 0.0 4.3e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 T342984_1 - 0.0005 19.3 0.0 0.00084 18.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ubiquitin PF00240.21 T342984_1 - 0.00055 19.5 0.0 0.0012 18.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family APH PF01636.21 T342984_1 - 0.015 15.1 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.7 T342984_1 - 0.043 13.2 0.0 0.073 12.4 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL SSFA2_C PF14723.4 T342984_1 - 0.15 11.8 0.6 0.27 11.0 0.6 1.3 1 0 0 1 1 1 0 Sperm-specific antigen 2 C-terminus Glyco_hydro_65m PF03632.13 T342984_1 - 0.23 10.1 0.0 0.37 9.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65 central catalytic domain IKKbetaNEMObind PF12179.6 T342984_3 - 8.6e-16 57.5 1.8 1.8e-15 56.5 1.8 1.6 1 0 0 1 1 1 1 I-kappa-kinase-beta NEMO binding domain Med30 PF11315.6 T342984_3 - 0.94 9.6 4.9 0.5 10.5 2.7 1.6 2 0 0 2 2 2 0 Mediator complex subunit 30 V-set PF07686.15 T301028_2 - 7.7e-06 25.9 0.0 0.13 12.3 0.0 2.3 1 1 1 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 T301028_2 - 6.7e-05 23.3 0.0 0.00027 21.4 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 T301028_2 - 0.0036 17.5 0.0 0.012 15.7 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 T301028_2 - 0.0088 16.1 0.0 0.096 12.7 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T301028_2 - 0.028 14.3 0.0 0.36 10.8 0.0 2.2 1 1 0 1 1 1 0 Immunoglobulin I-set domain KASH PF10541.7 T313741_1 - 6.8e-27 93.4 6.0 2.2e-26 91.7 6.0 2.0 1 0 0 1 1 1 1 Nuclear envelope localisation domain Spectrin PF00435.19 T313741_3 - 1.8e-138 452.5 800.5 2.1e-10 40.9 8.5 74.7 68 9 7 75 75 75 47 Spectrin repeat CH PF00307.29 T313741_3 - 5.5e-44 148.7 2.0 2.8e-20 72.4 0.0 5.3 4 0 0 4 4 4 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 T313741_3 - 1.5e-06 27.8 0.0 0.031 14.0 0.0 3.4 2 0 0 2 2 2 2 CAMSAP CH domain Coatomer_g_Cpla PF16381.3 T313741_3 - 0.14 12.1 2.2 4.1 7.4 0.1 4.7 3 0 0 3 3 3 0 Coatomer subunit gamma-1 C-terminal appendage platform MukB PF04310.10 T313741_3 - 1.9 8.1 9.9 3 7.5 0.2 5.3 4 0 0 4 4 4 0 MukB N-terminal Pkinase_Tyr PF07714.15 T170489_1 - 3.4e-128 426.3 0.0 3.8e-79 265.5 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.23 T170489_1 - 4.9e-60 203.0 0.0 2.3e-45 154.9 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain Kdo PF06293.12 T170489_1 - 0.029 13.6 0.0 0.33 10.1 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DNA_pol_B_thumb PF14791.4 T046690_3 - 7.3e-18 64.3 0.4 1.3e-17 63.5 0.4 1.5 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.7 T046690_3 - 8.5e-16 57.5 0.0 1.6e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.4 T046690_3 - 2.7e-10 40.3 0.0 1e-09 38.5 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase beta palm HHH_8 PF14716.4 T046690_3 - 6.8e-08 32.6 0.0 1.2e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain NTP_transf_2 PF01909.21 T046690_3 - 6.3e-07 29.5 0.0 1.9e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 Nucleotidyltransferase domain Dimer_Tnp_hAT PF05699.12 T370619_1 - 8.1e-15 54.3 0.0 2.3e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-BED PF02892.13 T370619_1 - 7.5e-14 51.4 0.9 7.5e-14 51.4 0.9 2.0 2 0 0 2 2 2 1 BED zinc finger DUF4413 PF14372.4 T370619_1 - 0.00018 21.6 0.1 0.00045 20.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) LRR_9 PF14580.4 T044430_1 - 3.7e-13 49.2 1.8 9.6e-13 47.9 1.8 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 T044430_1 - 1.5e-05 25.1 12.0 3.4e-05 24.0 6.1 3.4 1 1 2 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T044430_1 - 0.13 11.9 9.0 0.12 12.1 6.3 2.4 2 1 1 3 3 3 0 Leucine rich repeat LRR_6 PF13516.4 T044430_1 - 3 8.0 4.3 35 4.7 0.3 3.4 3 0 0 3 3 3 0 Leucine Rich repeat Raftlin PF15250.4 T238747_3 - 5.6e-229 760.5 0.0 9.2e-229 759.8 0.0 1.4 1 0 0 1 1 1 1 Raftlin AMP-binding PF00501.26 T048714_2 - 1.3e-112 376.4 0.0 1.7e-112 376.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 T048714_2 - 0.0024 18.7 0.0 0.0048 17.7 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Peptidase_M19 PF01244.19 T134994_3 - 5.3e-96 321.4 0.0 7.3e-96 320.9 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Filament PF00038.19 T147287_1 - 4.3e-94 315.5 32.2 5e-94 315.2 32.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein UPF0184 PF03670.11 T147287_1 - 2.7 8.3 11.2 2.3 8.6 0.1 3.3 3 1 2 5 5 5 0 Uncharacterised protein family (UPF0184) ERM PF00769.17 T147287_1 - 4 7.1 23.1 1.3e+02 2.1 22.9 2.3 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Baculo_PEP_C PF04513.10 T147287_1 - 6.3 6.7 16.1 1.8 8.4 1.4 3.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.10 T147287_1 - 8.3 6.4 35.7 2 8.4 4.4 3.4 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein NYD-SP28_assoc PF14775.4 T147287_1 - 9.1 6.3 10.6 6.2 6.9 0.8 3.8 3 0 0 3 3 3 0 Sperm tail C-terminal domain Reo_sigmaC PF04582.10 T147287_1 - 10 5.3 6.6 15 4.7 0.4 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Filament PF00038.19 T147439_1 - 3e-53 181.3 16.6 6.2e-23 81.7 5.3 4.0 4 0 0 4 4 4 4 Intermediate filament protein Filament PF00038.19 T147439_2 - 1.2e-18 67.6 0.7 1.6e-18 67.2 0.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament PF00038.19 T147439_3 - 8.1e-05 22.2 1.0 8.1e-05 22.2 1.0 1.8 2 0 0 2 2 2 1 Intermediate filament protein Mpv17_PMP22 PF04117.10 T170559_1 - 8.7e-28 96.2 0.3 2e-27 95.0 0.3 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family GILT PF03227.14 T170559_1 - 4.1e-27 94.3 0.4 9.1e-27 93.2 0.4 1.6 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) DUF1908 PF08926.9 T170559_2 - 4.3e-126 419.7 0.0 8.7e-126 418.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1908) Pkinase PF00069.23 T170559_2 - 1.4e-60 204.8 0.0 1.8e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T170559_2 - 1.5e-26 93.1 0.0 2.2e-26 92.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.22 T170559_2 - 4.6e-08 33.2 0.0 8.6e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T170559_2 - 3.2e-05 24.0 0.0 6.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Kinase-like PF14531.4 T170559_2 - 0.0036 16.5 0.0 0.0056 15.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Tricorn_PDZ PF14685.4 T170559_2 - 0.1 12.5 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Tricorn protease PDZ domain PI3K_P85_iSH2 PF16454.3 T170559_3 - 1.9e-57 193.2 21.5 2.5e-57 192.8 21.5 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.22 T170559_3 - 5.6e-38 128.7 0.1 1.2e-18 66.8 0.0 2.4 2 0 0 2 2 2 2 SH2 domain RhoGAP PF00620.25 T170559_3 - 3.9e-11 42.9 0.0 7.8e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain SH3_9 PF14604.4 T170559_3 - 0.016 14.9 0.0 0.034 13.8 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.26 T170559_3 - 0.057 12.9 0.0 0.21 11.1 0.0 2.0 2 0 0 2 2 2 0 SH3 domain MAGE_N PF12440.6 T381444_2 - 4.5e-24 84.8 8.2 9.3e-24 83.8 8.2 1.6 1 0 0 1 1 1 1 Melanoma associated antigen family N terminal MAGE PF01454.17 T381444_2 - 2.4e-12 46.9 0.0 6.5e-11 42.2 0.0 2.1 1 1 0 1 1 1 1 MAGE family Filament PF00038.19 T078883_1 - 2.4e-97 326.1 30.1 3e-97 325.8 30.1 1.1 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 T078883_1 - 1.6e-12 47.8 2.6 1.6e-12 47.8 2.6 2.5 2 0 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 T078883_1 - 1.3e-07 31.6 22.2 0.00015 21.7 0.9 3.4 3 0 0 3 3 3 2 TPR/MLP1/MLP2-like protein DUF4924 PF16271.3 T078883_1 - 0.0071 16.2 0.5 0.013 15.4 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4924) Spc7 PF08317.9 T078883_1 - 0.032 13.0 22.4 0.2 10.3 8.8 2.7 1 1 0 2 2 2 0 Spc7 kinetochore protein BAT PF15915.3 T078883_1 - 0.081 12.7 0.6 0.16 11.7 0.6 1.4 1 0 0 1 1 1 0 GAF and HTH_10 associated domain DUF1635 PF07795.9 T078883_1 - 0.2 11.5 4.5 0.39 10.5 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) CALCOCO1 PF07888.9 T078883_1 - 1.2 7.4 24.1 7.8 4.8 24.1 1.8 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc42p PF11544.6 T078883_1 - 1.4 8.9 5.1 0.44 10.4 0.4 2.3 2 0 0 2 2 2 0 Spindle pole body component Spc42p SPATA1_C PF15743.3 T078883_1 - 4.3 7.3 14.9 1.3 9.0 0.5 2.6 3 0 0 3 3 3 0 Spermatogenesis-associated C-terminus BRE1 PF08647.9 T078883_1 - 5.8 6.9 13.4 0.67 9.9 0.3 3.1 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Tropomyosin_1 PF12718.5 T078883_1 - 7.1 6.6 25.4 0.062 13.3 8.1 3.3 2 1 0 3 3 3 0 Tropomyosin like Filament PF00038.19 T078883_2 - 4.1e-25 88.9 10.5 5.4e-25 88.5 10.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Filament PF00038.19 T078883_3 - 0.071 12.6 0.1 0.098 12.1 0.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein WD40 PF00400.30 T101642_1 - 6.2e-19 67.9 17.1 0.00016 22.2 0.5 7.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T101642_1 - 7.8e-06 26.0 0.1 0.79 9.9 0.0 4.7 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain DUF3606 PF12244.6 T101642_2 - 0.31 10.9 0.6 0.52 10.2 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) Glyco_transf_22 PF03901.15 T117042_3 - 6.8e-117 391.1 43.1 5.8e-92 308.9 28.9 2.2 2 0 0 2 2 2 2 Alg9-like mannosyltransferase family PMT_2 PF13231.4 T117042_3 - 0.0004 20.6 3.8 0.0004 20.6 3.8 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Homeobox PF00046.27 T192159_2 - 1e-18 66.7 7.0 1e-18 66.7 7.0 1.7 2 0 0 2 2 2 1 Homeobox domain Homez PF11569.6 T192159_2 - 0.14 11.5 0.2 0.28 10.6 0.2 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez KRAB PF01352.25 T168014_2 - 4.3e-25 87.0 0.6 9.5e-25 85.9 0.6 1.6 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 T168014_3 - 6.2e-28 95.8 46.8 8.5e-08 32.2 2.3 8.3 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2 PF00096.24 T168014_3 - 1.5e-23 81.7 42.1 2e-05 24.6 0.3 7.6 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T168014_3 - 3.6e-08 33.4 32.4 0.041 14.6 0.4 7.3 6 0 0 6 6 6 4 C2H2-type zinc finger DUF1725 PF08333.9 T168014_3 - 6.4e-07 28.7 1.3 1.7e-06 27.4 1.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) XPA_N PF01286.16 T168014_3 - 0.0002 21.2 14.0 0.68 9.9 0.2 5.1 5 0 0 5 5 5 4 XPA protein N-terminal zf-C2H2_jaz PF12171.6 T168014_3 - 0.0012 18.9 14.6 1.7 8.9 0.9 5.6 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T168014_3 - 0.018 15.1 15.9 0.094 12.7 1.6 3.3 3 1 0 3 3 3 0 Zinc ribbon domain zf-C2H2_6 PF13912.4 T168014_3 - 0.026 14.4 26.8 1.1 9.1 0.0 5.6 6 0 0 6 6 6 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T168014_3 - 0.38 11.4 15.3 0.53 10.9 0.9 3.0 1 1 2 3 3 3 0 zinc-ribbon family zf-trcl PF13451.4 T168014_3 - 0.4 10.5 17.3 4.2 7.2 0.2 5.1 5 0 0 5 5 5 0 Probable zinc-ribbon domain Glyco_hydro_31 PF01055.24 T115248_1 - 1.3e-151 505.6 3.0 1.7e-151 505.2 3.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.4 T115248_1 - 1.9e-18 66.4 0.3 7.3e-18 64.5 0.2 2.1 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.2 T115248_1 - 0.003 17.7 0.0 0.0067 16.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Peptidase_C2 PF00648.19 T115248_2 - 2.8e-126 420.4 2.6 4.2e-126 419.8 2.6 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 T115248_2 - 1.6e-55 187.2 0.0 3.1e-55 186.2 0.0 1.5 1 0 0 1 1 1 1 Calpain large subunit, domain III Calpain_u2 PF16648.3 T115248_2 - 2.3e-31 107.9 10.8 3.8e-31 107.2 10.8 1.3 1 0 0 1 1 1 1 Unstructured region on Calpain-3 EF-hand_1 PF00036.30 T115248_2 - 4.4e-16 57.0 0.7 5.1e-05 22.4 0.0 3.9 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 T115248_2 - 4.8e-13 47.8 2.8 0.0012 18.5 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 T115248_2 - 1.5e-10 40.5 4.8 6.9e-08 32.0 0.2 3.6 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 T115248_2 - 2.8e-07 29.6 1.1 0.23 10.9 0.0 3.7 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 T115248_2 - 7.3e-07 29.4 6.5 0.018 15.3 0.5 3.6 3 1 1 4 4 4 2 EF-hand domain pair NIF PF03031.16 T207698_1 - 2.5e-50 170.1 0.0 3.4e-50 169.7 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Nramp PF01566.16 T207698_1 - 5.3e-11 42.0 0.0 8.1e-11 41.4 0.0 1.2 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Nramp PF01566.16 T207698_2 - 1.4e-96 323.5 13.3 1.8e-96 323.1 13.3 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein zf-C2H2 PF00096.24 T307685_3 - 2.6e-11 43.2 100.1 0.0059 16.9 0.3 16.5 16 0 0 16 16 16 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T307685_3 - 0.00018 21.9 103.9 0.44 11.4 2.3 16.6 17 0 0 17 17 17 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T307685_3 - 0.0034 17.2 41.1 0.8 9.6 0.5 8.7 8 0 0 8 8 8 4 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T307685_3 - 0.015 14.9 2.5 3.7 7.3 0.1 3.9 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zinc_ribbon_11 PF11682.6 T307685_3 - 0.026 14.4 0.3 0.075 12.9 0.3 1.8 1 0 0 1 1 1 0 Probable zinc-ribbon zf-C2H2_jaz PF12171.6 T307685_3 - 0.86 9.9 31.5 0.79 10.0 0.1 8.4 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding Sec8_exocyst PF04048.12 T333574_1 - 7.7e-18 64.6 1.4 7.7e-18 64.6 1.4 2.5 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.7 T333574_1 - 0.0036 16.5 5.5 0.0036 16.5 5.5 2.3 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex COG5 PF10392.7 T333574_1 - 0.24 11.5 8.8 0.12 12.4 3.6 3.2 3 1 1 4 4 4 0 Golgi transport complex subunit 5 AAA_15 PF13175.4 T333574_1 - 0.24 10.8 6.0 4.9 6.5 6.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain Dor1 PF04124.10 T333574_1 - 0.39 9.2 12.8 0.71 8.4 8.7 2.4 2 0 0 2 2 2 0 Dor1-like family Vps51 PF08700.9 T333574_1 - 0.52 10.3 8.4 9 6.3 0.1 3.8 3 0 0 3 3 3 0 Vps51/Vps67 DUF948 PF06103.9 T333574_1 - 1.7 8.8 5.9 5.3 7.2 0.0 3.8 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) WD40 PF00400.30 T254086_1 - 9e-19 67.4 9.4 0.0011 19.6 0.0 8.6 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T254086_1 - 0.092 12.9 0.3 1.1 9.4 0.1 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Serpin PF00079.18 T254086_2 - 3.2e-106 355.6 6.8 4.4e-106 355.2 6.8 1.2 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RhoGAP PF00620.25 T008340_1 - 1.2e-25 90.0 0.2 2.1e-25 89.2 0.2 1.3 1 0 0 1 1 1 1 RhoGAP domain zf-H2C2_2 PF13465.4 T008340_1 - 9.4e-21 73.1 50.0 4.7e-07 29.8 0.4 7.9 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2 PF00096.24 T008340_1 - 5.9e-20 70.4 50.0 0.00055 20.1 1.3 7.6 7 0 0 7 7 7 6 Zinc finger, C2H2 type INPP5B_PH PF16776.3 T008340_1 - 2.8e-12 46.5 0.0 4.8e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain Exo_endo_phos PF03372.21 T008340_1 - 5.5e-09 36.2 0.0 9.4e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-C2H2_4 PF13894.4 T008340_1 - 2.3e-07 30.9 55.8 0.049 14.3 0.8 8.7 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_8 PF15909.3 T008340_1 - 1.5e-06 28.2 20.0 0.016 15.3 2.0 3.7 1 1 2 3 3 3 3 C2H2-type zinc ribbon Marek_A PF02124.13 T008340_1 - 0.013 15.2 0.4 4.1 7.1 0.2 2.5 2 0 0 2 2 2 0 Marek's disease glycoprotein A zf-C2H2_6 PF13912.4 T008340_1 - 0.015 15.1 19.2 0.26 11.2 0.7 5.7 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T008340_1 - 0.37 11.0 18.0 0.4 10.9 1.8 5.1 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding INPP5B_PH PF16776.3 T008340_2 - 3.1e-37 127.4 0.0 4.8e-37 126.8 0.0 1.2 1 0 0 1 1 1 1 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain SRRM_C PF15230.4 T087469_1 - 5.2e-23 81.2 28.0 5.2e-23 81.2 28.0 3.9 2 1 1 3 3 3 1 Serine/arginine repetitive matrix protein C-terminus Histone PF00125.22 T299675_3 - 1.5e-24 86.7 0.3 2.4e-24 86.1 0.3 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 T299675_3 - 1.8e-05 24.8 0.0 3.3e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 T299675_3 - 0.057 13.8 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A V-set PF07686.15 T156900_3 - 3e-14 52.9 0.2 9.9e-13 48.1 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T156900_3 - 1.7e-09 38.0 0.5 6.5e-06 26.5 0.4 3.0 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 T156900_3 - 6.7e-05 23.0 0.4 0.00025 21.2 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 T156900_3 - 0.00013 21.9 0.3 0.0022 17.9 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 T156900_3 - 0.00077 19.4 0.1 0.0039 17.2 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain EF-hand_6 PF13405.4 T082521_2 - 2.7e-10 39.2 0.9 0.0013 18.4 0.3 3.9 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.30 T082521_2 - 6.4e-08 31.5 3.1 0.016 14.6 0.1 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 T082521_2 - 2.9e-07 30.7 1.3 1.8e-05 25.0 0.3 2.5 1 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.4 T082521_2 - 0.00073 19.1 0.1 0.0031 17.1 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.4 T082521_2 - 0.0024 17.2 4.5 0.7 9.4 0.2 3.4 3 0 0 3 3 3 2 EF hand Pkinase PF00069.23 T290896_3 - 7.7e-57 192.5 0.3 1e-56 192.1 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T290896_3 - 6.1e-33 114.1 0.3 8.3e-33 113.6 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T290896_3 - 3.3e-10 39.6 0.0 5.1e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 T290896_3 - 0.02 14.7 0.1 0.032 14.0 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family STAT_bind PF02864.13 T080457_1 - 7.3e-83 278.1 0.0 1e-82 277.7 0.0 1.2 1 0 0 1 1 1 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 T080457_1 - 1.7e-12 47.4 0.6 3e-12 46.6 0.6 1.3 1 0 0 1 1 1 1 STAT protein, all-alpha domain SH2 PF00017.22 T080457_1 - 2.5e-10 40.1 0.0 4.3e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 SH2 domain STAT_int PF02865.15 T080457_1 - 0.029 14.7 0.0 0.063 13.6 0.0 1.6 1 0 0 1 1 1 0 STAT protein, protein interaction domain STAT_int PF02865.15 T080457_2 - 1.9e-05 25.0 0.0 2.8e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 STAT protein, protein interaction domain STAT6_C PF14596.4 T080457_3 - 1.8e-110 367.3 18.1 3.7e-110 366.3 18.1 1.5 1 0 0 1 1 1 1 STAT6 C-terminal Methyltr_RsmB-F PF01189.15 T263861_3 - 3.2e-06 26.8 0.1 7e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F RRM_1 PF00076.20 T100661_1 - 7.5e-12 44.8 0.1 1.3e-11 44.0 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_2 PF13347.4 T352656_2 - 5.9e-08 31.5 0.7 5.9e-08 31.5 0.7 2.2 2 0 0 2 2 2 1 MFS/sugar transport protein DUF4509 PF14970.4 T111933_1 - 1.6e-66 223.7 0.0 2.4e-66 223.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4509) DUF4510 PF14971.4 T111933_1 - 2e-42 145.0 5.7 6.7e-42 143.4 5.7 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4510) CECR6_TMEM121 PF14997.4 T111933_3 - 5.1e-56 189.5 3.2 6.9e-56 189.1 3.2 1.2 1 0 0 1 1 1 1 CECR6/TMEM121 family Transposase_22 PF02994.12 T109469_1 - 2.6e-40 138.3 5.9 4.2e-40 137.6 5.9 1.2 1 0 0 1 1 1 1 L1 transposable element Serpin PF00079.18 T109469_2 - 2.7e-102 342.7 0.0 3.6e-102 342.3 0.0 1.2 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RVT_1 PF00078.25 T109469_2 - 3.9e-21 75.5 0.3 6.4e-21 74.8 0.3 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Serpin PF00079.18 T109469_3 - 6.1e-109 364.6 4.5 8.2e-109 364.2 4.5 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Transposase_22 PF02994.12 T109469_3 - 7.3e-19 67.7 0.1 7.3e-19 67.7 0.1 1.6 2 0 0 2 2 2 1 L1 transposable element DUF1725 PF08333.9 T109469_3 - 2.3e-05 23.8 0.1 6.9e-05 22.3 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) V-set PF07686.15 T247970_2 - 2.8e-08 33.7 4.8 3.6e-05 23.8 0.5 2.9 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 T247970_2 - 1.6e-06 28.5 7.1 0.0039 17.6 0.4 4.6 3 1 1 4 4 4 2 Immunoglobulin domain ig PF00047.23 T247970_2 - 5.8e-05 23.1 4.7 0.073 13.1 0.4 3.3 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.10 T247970_2 - 0.00048 20.0 0.0 0.0058 16.5 0.0 2.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain AMP-binding PF00501.26 T182583_1 - 2e-37 128.7 0.0 3.1e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 T182583_1 - 2.6e-08 34.6 0.0 5e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain BTB PF00651.29 T182583_3 - 1.6e-19 70.0 0.0 2.8e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 T182583_3 - 6.8e-16 57.8 18.1 0.0003 21.0 0.2 5.0 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.24 T182583_3 - 2.3e-15 55.9 33.7 5.2e-05 23.3 1.1 6.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T182583_3 - 5.6e-07 29.7 38.6 0.0077 16.8 1.2 5.9 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T182583_3 - 2.8e-05 24.2 7.5 0.064 13.5 1.8 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 T182583_3 - 0.0053 16.6 23.0 0.039 13.8 0.3 5.5 5 0 0 5 5 5 2 C2H2-type zinc finger zf-met PF12874.5 T182583_3 - 0.026 14.8 22.6 1.1 9.6 1.1 4.6 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 T182583_3 - 0.027 14.1 16.5 1.1 9.0 0.6 4.7 4 0 0 4 4 4 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T182583_3 - 0.07 13.1 9.6 0.07 13.1 1.3 3.0 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2_2 PF12756.5 T182583_3 - 0.47 10.7 13.4 0.62 10.3 10.2 2.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) T-box PF00907.20 T315176_3 - 3.4e-72 242.4 0.0 5.7e-72 241.7 0.0 1.4 1 0 0 1 1 1 1 T-box TRPM_tetra PF16519.3 T360131_3 - 1.2e-23 82.8 5.4 2.5e-23 81.8 5.4 1.6 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.29 T360131_3 - 1e-17 64.1 17.4 1.6e-17 63.5 17.4 1.2 1 0 0 1 1 1 1 Ion transport protein DUF3552 PF12072.6 T360131_3 - 0.079 12.2 4.2 0.16 11.3 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) SMK-1 PF04802.13 T109016_3 - 7.1e-81 270.5 5.9 1.5e-80 269.4 5.9 1.6 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.21 T109016_3 - 0.005 16.6 0.0 0.0096 15.7 0.0 1.4 1 0 0 1 1 1 1 WH1 domain Ran_BP1 PF00638.16 T109016_3 - 0.047 13.8 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 RanBP1 domain zf-C3HC4_2 PF13923.4 T201050_1 - 0.0038 16.9 11.0 5.8 6.7 0.2 5.1 4 0 0 4 4 4 3 Zinc finger, C3HC4 type (RING finger) Nebulin PF00880.16 T201050_2 - 0 2120.3 516.7 7.6e-09 35.2 0.0 136.9 140 0 0 140 140 140 126 Nebulin repeat Peptidase_M24 PF00557.22 T201050_2 - 1.1e-15 57.8 8.3 0.17 11.4 0.0 10.2 12 0 0 12 12 12 6 Metallopeptidase family M24 DUF1310 PF07006.9 T201050_2 - 0.00033 20.5 0.6 27 4.6 0.0 5.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1310) DUF4633 PF15464.4 T201050_2 - 0.22 11.5 5.3 24 4.9 0.0 7.1 6 1 0 7 7 7 0 Domain of unknown function (DUF4633) ACAS_N PF16177.3 T201050_2 - 0.4 10.5 2.7 2.2e+02 1.7 0.1 5.2 3 0 0 3 3 3 0 Acetyl-coenzyme A synthetase N-terminus DUF1972 PF09314.9 T201050_2 - 0.42 10.1 5.4 1.4 8.4 0.7 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1972) zf-C2H2_6 PF13912.4 T201203_1 - 2.5 8.0 7.8 0.068 13.0 0.2 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Glycos_transf_2 PF00535.24 T201203_2 - 8e-36 123.3 0.0 1.2e-35 122.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 T201203_2 - 2.3e-33 115.0 6.0 2.7e-29 101.9 2.0 2.4 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 T201203_2 - 6.3e-05 22.4 0.1 0.00013 21.4 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.4 T201203_2 - 8.7e-05 23.1 0.1 0.94 10.1 0.0 3.3 3 0 0 3 3 3 1 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_2 PF10111.7 T201203_2 - 0.00019 20.9 0.0 0.00033 20.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 BAT2_N PF07001.9 T025087_3 - 2.9e-53 181.1 11.5 2.9e-53 181.1 11.5 11.2 12 3 1 14 14 14 1 BAT2 N-terminus NAM-associated PF14303.4 T025087_3 - 0.046 14.3 0.0 0.046 14.3 0.0 8.8 5 3 2 7 7 7 0 No apical meristem-associated C-terminal domain 7tm_1 PF00001.19 T307796_1 - 3.3e-43 147.7 15.5 5.3e-43 147.0 15.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ERM PF00769.17 T265055_2 - 0.014 15.1 71.1 0.1 12.3 10.2 3.1 2 1 1 3 3 3 0 Ezrin/radixin/moesin family Reo_sigmaC PF04582.10 T265055_2 - 0.78 8.9 26.4 0.11 11.7 4.0 3.6 1 1 3 4 4 4 0 Reovirus sigma C capsid protein ATG16 PF08614.9 T265055_2 - 2 8.4 68.0 1.7 8.7 25.1 3.8 1 1 2 4 4 4 0 Autophagy protein 16 (ATG16) GAS PF13851.4 T265055_2 - 3.3 6.9 64.5 0.22 10.7 12.1 4.2 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding Trimer_CC PF08954.9 T265055_2 - 4.7 6.7 7.0 0.2 11.1 0.1 2.3 3 0 0 3 3 3 0 Trimerisation motif Fez1 PF06818.13 T265055_2 - 5.8 7.2 61.6 1.2 9.4 18.9 3.4 1 1 2 3 3 3 0 Fez1 Golgin_A5 PF09787.7 T265055_2 - 6.3 6.0 66.6 1.4 8.2 21.8 3.8 1 1 3 4 4 4 0 Golgin subfamily A member 5 Reo_sigmaC PF04582.10 T265055_3 - 0.18 11.1 29.5 0.061 12.6 0.6 5.2 2 1 1 5 5 5 0 Reovirus sigma C capsid protein 4HBT_3 PF13622.4 T218693_3 - 6.6e-47 160.7 1.0 8.3e-47 160.4 1.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.13 T218693_3 - 3.2e-27 94.8 0.1 8.4e-25 87.0 0.0 2.3 2 0 0 2 2 2 2 Acyl-CoA thioesterase 4HBT PF03061.20 T218693_3 - 0.049 13.8 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Thioesterase superfamily 7tm_2 PF00002.22 T133250_1 - 7.3e-20 71.2 1.8 1.1e-19 70.6 1.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 T133250_1 - 1.3e-12 48.0 6.0 1.3e-12 48.0 6.0 2.3 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif DUF2162 PF09930.7 T133250_1 - 0.25 10.6 4.6 1.4 8.1 1.4 2.1 1 1 1 2 2 2 0 Predicted transporter (DUF2162) 7tm_2 PF00002.22 T133250_2 - 1.1e-28 100.0 16.8 1.7e-28 99.4 16.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 T133250_2 - 2.3e-12 47.2 3.1 2.3e-12 47.2 3.1 2.9 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.22 T133250_3 - 0.01 15.0 0.2 0.015 14.5 0.2 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) V-set PF07686.15 T334728_3 - 3.4e-09 36.7 0.4 7e-09 35.7 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 T334728_3 - 0.00015 22.2 0.0 0.0004 20.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T334728_3 - 0.0033 17.3 0.0 0.0064 16.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 T334728_3 - 0.029 14.6 0.0 0.081 13.1 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin domain HEAT PF02985.20 T220949_1 - 3.4e-16 57.8 15.0 0.015 15.3 0.5 8.0 8 0 0 8 8 8 5 HEAT repeat HEAT_2 PF13646.4 T220949_1 - 3e-07 30.6 0.0 1 9.7 0.0 5.7 4 1 3 7 7 7 2 HEAT repeats Cnd1 PF12717.5 T220949_1 - 0.0046 16.8 0.1 2 8.3 0.0 3.9 4 1 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 T220949_1 - 0.18 12.2 2.2 2.5 8.5 0.1 3.3 3 0 0 3 3 3 0 HEAT-like repeat zinc_ribbon_9 PF14369.4 T165286_1 - 2.5e-07 30.7 5.7 8.3e-07 29.0 5.7 2.0 1 0 0 1 1 1 1 zinc-ribbon zf-RING_2 PF13639.4 T165286_3 - 8.2e-13 48.3 5.8 3.3e-12 46.3 5.8 2.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 T165286_3 - 5.3e-09 35.7 5.5 5.3e-09 35.7 5.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 T165286_3 - 2.1e-07 30.4 0.8 5.4e-07 29.1 0.8 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.5 T165286_3 - 2.6e-07 30.7 4.0 8.2e-07 29.1 4.0 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 T165286_3 - 4e-06 26.5 3.4 9.2e-06 25.3 3.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 T165286_3 - 1.7e-05 24.5 3.1 7.3e-05 22.5 3.1 2.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 T165286_3 - 1.9e-05 24.4 3.0 3.2e-05 23.7 1.6 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 T165286_3 - 2.3e-05 24.0 1.8 6.3e-05 22.6 1.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 T165286_3 - 0.00017 21.2 5.2 0.00078 19.1 5.3 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 T165286_3 - 0.0002 21.2 2.1 0.00057 19.8 2.1 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.3 T165286_3 - 0.09 12.3 3.3 0.22 11.0 3.3 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Rad50_zn_hook PF04423.12 T165286_3 - 0.39 10.5 1.2 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING-like PF08746.9 T165286_3 - 5.1 7.4 8.7 0.36 11.0 3.0 2.2 2 0 0 2 2 1 0 RING-like domain Folliculin_C PF16692.3 T142953_2 - 5.7e-91 304.1 0.1 7.7e-91 303.6 0.1 1.2 1 0 0 1 1 1 1 Folliculin C-terminal domain Folliculin PF11704.6 T142953_2 - 5.1e-51 172.9 0.0 7.8e-51 172.3 0.0 1.3 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport PH PF00169.27 T228687_2 - 1.1e-19 70.7 0.5 1.7e-19 70.1 0.5 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 T228687_2 - 5.8e-06 26.5 1.5 1.4e-05 25.3 1.5 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.8 T228687_2 - 0.14 12.4 0.1 0.25 11.6 0.1 1.3 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Kelch_1 PF01344.23 T137280_1 - 7e-27 92.6 10.7 1.4e-07 30.8 0.0 5.4 4 1 0 4 4 4 4 Kelch motif Kelch_6 PF13964.4 T137280_1 - 4.9e-24 83.6 2.7 4.5e-05 23.5 0.0 4.9 3 1 1 4 4 4 4 Kelch motif Kelch_2 PF07646.13 T137280_1 - 4.4e-11 42.1 4.3 0.017 15.0 0.1 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.4 T137280_1 - 8e-10 38.4 3.1 0.0054 16.5 0.0 3.9 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.4 T137280_1 - 1.9e-07 31.1 3.7 0.56 10.4 0.0 4.7 4 0 0 4 4 4 3 Galactose oxidase, central domain BTB PF00651.29 T137280_2 - 3.8e-25 88.1 0.0 6.3e-25 87.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 T137280_2 - 1.3e-21 76.5 0.3 2.1e-21 75.8 0.3 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_5 PF13854.4 T137280_2 - 0.00029 20.6 0.1 0.00078 19.2 0.1 1.7 1 0 0 1 1 1 1 Kelch motif Cse1 PF08506.8 T219440_1 - 8.9e-167 554.4 6.0 1.8e-166 553.4 6.0 1.5 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.13 T219440_1 - 1.3e-145 485.2 7.7 1.3e-145 485.2 7.7 2.1 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.17 T219440_1 - 2.9e-10 39.8 0.3 1.4e-09 37.5 0.1 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.10 T219440_1 - 0.0018 18.2 1.4 0.017 15.1 0.0 3.0 1 1 1 2 2 2 1 Exportin 1-like protein CAS_CSE1 PF03378.13 T219440_3 - 5.2e-23 81.1 0.0 6.7e-23 80.7 0.0 1.1 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Cor1 PF04803.10 T085152_3 - 3.1e-58 195.6 33.3 5.4e-58 194.8 33.3 1.4 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region Peptidase_C65 PF10275.7 T085152_3 - 0.0019 17.6 8.0 0.0028 17.0 8.0 1.3 1 0 0 1 1 1 1 Peptidase C65 Otubain UCH PF00443.27 T367623_1 - 4.7e-60 203.1 0.0 1.6e-59 201.4 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.10 T367623_1 - 4.2e-26 91.3 0.3 3.4e-16 59.5 0.0 2.7 2 0 0 2 2 2 2 DUSP domain UCH_1 PF13423.4 T367623_1 - 3.6e-22 79.2 0.0 3.5e-21 76.0 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 T367623_1 - 6e-16 58.4 5.8 3.9e-15 55.8 5.8 2.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein RhoGEF PF00621.18 T105922_3 - 1.7e-44 152.1 0.6 2.6e-44 151.5 0.6 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 T105922_3 - 1.3e-07 32.0 0.2 2.8e-07 30.8 0.2 1.6 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 T105922_3 - 0.013 15.6 1.1 0.14 12.3 1.0 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.3 T105922_3 - 0.076 12.8 0.2 0.15 11.8 0.2 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain DNA_pol_phi PF04931.11 T105922_3 - 1.5 6.7 7.5 2.2 6.1 7.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi RR_TM4-6 PF06459.10 T105922_3 - 1.7 8.2 5.5 3.6 7.2 5.5 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CATSPERD PF15020.4 T034359_3 - 2.9e-09 35.7 0.1 6.7e-09 34.5 0.1 1.5 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit delta DEAD PF00270.27 T233700_1 - 6.6e-48 162.7 0.0 1.2e-47 161.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T233700_1 - 3.3e-14 53.1 0.0 5.7e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C PF00271.29 T233700_2 - 2.4e-06 27.8 0.0 4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ets PF00178.20 T084518_3 - 1.6e-33 114.9 3.0 2.6e-33 114.2 3.0 1.3 1 0 0 1 1 1 1 Ets-domain Filament PF00038.19 T078950_1 - 8.4e-76 255.4 15.6 1.1e-75 255.0 15.6 1.1 1 0 0 1 1 1 1 Intermediate filament protein Spc7 PF08317.9 T078950_1 - 0.00055 18.8 5.3 0.00055 18.8 5.3 2.2 1 1 1 2 2 2 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 T078950_1 - 0.00078 19.4 8.9 0.00078 19.4 8.9 1.8 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.7 T078950_1 - 0.004 17.1 7.5 0.0063 16.4 6.5 1.8 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.6 T078950_1 - 0.0061 16.5 5.8 0.0061 16.5 5.8 1.8 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding Alanine_zipper PF11839.6 T078950_1 - 0.0096 16.0 3.5 0.018 15.1 3.5 1.4 1 0 0 1 1 1 1 Alanine-zipper, major outer membrane lipoprotein Taxilin PF09728.7 T078950_1 - 0.028 13.6 8.9 0.14 11.3 8.9 1.8 1 1 0 1 1 1 0 Myosin-like coiled-coil protein DUF812 PF05667.9 T078950_1 - 0.032 13.0 8.4 0.046 12.5 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Lebercilin PF15619.4 T078950_1 - 0.035 13.6 7.2 0.062 12.8 7.2 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Vps53_N PF04100.10 T078950_1 - 0.037 12.9 2.9 0.055 12.3 2.9 1.1 1 0 0 1 1 1 0 Vps53-like, N-terminal Transposase_22 PF02994.12 T078950_1 - 0.06 12.1 3.5 0.088 11.5 3.5 1.1 1 0 0 1 1 1 0 L1 transposable element AAA_13 PF13166.4 T078950_1 - 0.062 11.8 6.6 0.086 11.4 6.6 1.1 1 0 0 1 1 1 0 AAA domain IncA PF04156.12 T078950_1 - 0.065 12.9 14.0 1.1 8.9 14.0 2.2 1 1 0 1 1 1 0 IncA protein KASH_CCD PF14662.4 T078950_1 - 0.068 12.9 11.2 0.044 13.5 9.1 1.6 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Reo_sigmaC PF04582.10 T078950_1 - 0.083 12.1 6.6 0.4 9.9 0.8 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TMCO5 PF14992.4 T078950_1 - 0.089 12.2 7.3 0.13 11.6 7.3 1.2 1 0 0 1 1 1 0 TMCO5 family Golgin_A5 PF09787.7 T078950_1 - 0.13 11.6 12.9 0.1 11.9 8.3 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 Sec34 PF04136.13 T078950_1 - 0.13 12.0 2.8 0.28 10.9 2.8 1.5 1 0 0 1 1 1 0 Sec34-like family Exonuc_VII_L PF02601.13 T078950_1 - 0.14 11.6 2.9 0.23 10.9 2.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tropomyosin_1 PF12718.5 T078950_1 - 0.27 11.2 12.2 0.095 12.7 9.2 1.7 2 0 0 2 2 1 0 Tropomyosin like DUF342 PF03961.11 T078950_1 - 0.36 9.2 2.5 0.53 8.7 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) BRE1 PF08647.9 T078950_1 - 0.36 10.8 10.5 1.2 9.1 4.1 2.5 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF713 PF05218.12 T078950_1 - 0.38 10.3 2.0 0.32 10.6 0.5 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF713) DASH_Duo1 PF08651.8 T078950_1 - 0.4 10.4 2.0 2.7 7.7 0.7 2.3 2 0 0 2 2 2 0 DASH complex subunit Duo1 Uds1 PF15456.4 T078950_1 - 0.53 10.3 8.6 5.8 7.0 0.5 2.4 1 1 1 2 2 2 0 Up-regulated During Septation Nup88 PF10168.7 T078950_1 - 0.6 7.7 5.3 0.81 7.3 5.3 1.1 1 0 0 1 1 1 0 Nuclear pore component JIP_LZII PF16471.3 T078950_1 - 0.62 10.2 3.3 22 5.2 0.1 2.6 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II OmpH PF03938.12 T078950_1 - 0.68 9.8 16.0 1.3 8.9 10.7 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) GAS PF13851.4 T078950_1 - 0.73 9.0 12.5 0.84 8.8 10.1 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TMPIT PF07851.11 T078950_1 - 0.9 8.6 3.1 1.6 7.8 3.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein Baculo_PEP_C PF04513.10 T078950_1 - 0.93 9.4 6.3 1.8 8.5 1.7 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus KxDL PF10241.7 T078950_1 - 0.96 9.6 6.7 0.53 10.5 0.5 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein TMF_DNA_bd PF12329.6 T078950_1 - 1.3 8.9 7.3 4 7.4 0.4 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding V_ATPase_I PF01496.17 T078950_1 - 1.6 6.4 9.5 0.086 10.6 3.8 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF5082 PF16888.3 T078950_1 - 2 8.6 10.4 0.45 10.7 2.4 2.9 1 1 1 3 3 3 0 Domain of unknown function (DUF5082) TMF_TATA_bd PF12325.6 T078950_1 - 2 8.5 12.2 2.1 8.4 5.4 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4201 PF13870.4 T078950_1 - 2.2 7.8 10.5 0.7 9.4 7.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) DUF3450 PF11932.6 T078950_1 - 2.3 7.3 12.8 0.13 11.4 4.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Ax_dynein_light PF10211.7 T078950_1 - 2.4 7.9 9.5 2.9 7.7 6.8 2.0 1 1 1 2 2 2 0 Axonemal dynein light chain DUF4407 PF14362.4 T078950_1 - 2.4 7.3 8.2 4.7 6.3 8.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Bap31 PF05529.10 T078950_1 - 2.6 7.5 7.7 0.23 10.9 1.8 1.9 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like SlyX PF04102.10 T078950_1 - 3.4 8.2 8.3 0.51 10.9 1.4 2.5 1 1 1 2 2 2 0 SlyX Fez1 PF06818.13 T078950_1 - 5 7.4 11.6 8.1 6.7 11.6 1.2 1 0 0 1 1 1 0 Fez1 TBPIP PF07106.11 T078950_1 - 5.1 6.7 10.4 2 8.0 5.6 2.3 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Swi5 PF07061.9 T078950_1 - 5.2 7.1 5.2 19 5.2 5.2 1.9 1 1 0 1 1 1 0 Swi5 Fib_alpha PF08702.8 T078950_1 - 5.3 7.1 6.1 3.7 7.6 4.0 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family APG6 PF04111.10 T078950_1 - 6.3 6.0 13.2 0.84 8.8 7.4 1.8 1 1 1 2 2 2 0 Autophagy protein Apg6 TSNAXIP1_N PF15739.3 T078950_1 - 6.6 7.0 7.6 0.86 9.9 1.9 2.1 1 1 1 2 2 2 0 Translin-associated factor X-interacting N-terminus Mnd1 PF03962.13 T078950_1 - 7.6 6.2 11.3 1.3 8.7 6.8 1.8 1 1 1 2 2 2 0 Mnd1 family Atg14 PF10186.7 T078950_1 - 7.8 5.3 7.8 12 4.8 7.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 zf-C4H2 PF10146.7 T078950_1 - 8.7 6.4 7.0 14 5.8 5.3 1.8 1 1 1 2 2 2 0 Zinc finger-containing protein 7tm_3 PF00003.20 T000692_1 - 1.3e-28 100.3 14.9 1.3e-28 100.3 14.9 2.9 2 1 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 T000692_2 - 3.7e-71 239.9 0.0 4.7e-71 239.6 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region GLTP PF08718.9 T000692_2 - 4.4e-39 134.0 0.0 7e-39 133.3 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Peripla_BP_6 PF13458.4 T000692_2 - 7e-08 32.4 0.0 2.5e-07 30.6 0.3 1.6 2 0 0 2 2 2 1 Periplasmic binding protein MBOAT PF03062.17 T025833_2 - 1.9e-75 254.3 41.6 2.8e-75 253.7 41.6 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family C1q PF00386.19 T233240_1 - 1.3e-36 125.5 0.4 1.7e-36 125.1 0.4 1.2 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 T233240_1 - 1.8e-06 27.5 16.2 1.8e-06 27.5 16.2 4.5 5 0 0 5 5 5 1 Collagen triple helix repeat (20 copies) BmKX PF09132.8 T233240_2 - 0.99 9.3 4.8 3.4 7.6 4.8 2.0 1 0 0 1 1 1 0 BmKX Lipocalin PF00061.21 T310726_1 - 2.1e-26 92.7 1.4 2.9e-26 92.3 1.4 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 T310726_1 - 7.6e-06 25.8 1.0 1e-05 25.3 1.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family MBT PF02820.16 T008962_1 - 1.3e-47 159.9 0.0 1e-24 86.6 0.0 2.4 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 T008962_1 - 1.9e-35 121.6 0.1 3.2e-35 120.9 0.1 1.4 1 0 0 1 1 1 1 SLED domain RBR PF17208.1 T008962_1 - 2.2e-12 47.4 17.6 7.7e-12 45.7 17.6 2.1 1 0 0 1 1 1 1 RNA binding Region SAM_1 PF00536.28 T008962_2 - 5.6e-16 58.6 0.1 1e-15 57.8 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T008962_2 - 9.4e-07 28.7 0.0 1.6e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 T008962_2 - 0.0059 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain AlbA_2 PF04326.12 T008962_3 - 1.7e-20 73.4 0.0 2.7e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Putative DNA-binding domain Sec6 PF06046.11 T276953_2 - 5.8e-162 539.9 7.0 5.8e-162 539.9 7.0 1.3 2 0 0 2 2 2 1 Exocyst complex component Sec6 Baculo_PEP_C PF04513.10 T276953_2 - 0.32 10.9 6.0 0.15 12.0 2.7 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tma16 PF11176.6 T276953_2 - 0.46 10.2 2.6 13 5.5 0.4 2.6 2 0 0 2 2 2 0 Translation machinery-associated protein 16 Sec61_beta PF03911.14 T363738_1 - 5.2e-19 67.9 0.0 9.7e-19 67.0 0.0 1.5 1 0 0 1 1 1 1 Sec61beta family Myelin_PLP PF01275.17 T371611_2 - 2.2e-100 335.3 19.0 3.2e-100 334.7 19.0 1.2 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) RRM_1 PF00076.20 T218125_2 - 7.7e-16 57.6 0.1 1.2e-15 57.0 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 T218125_3 - 1.1e-12 47.4 0.0 1.7e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 T218125_3 - 0.003 17.5 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 RNA binding motif zf-H2C2_2 PF13465.4 T088569_3 - 3.1e-55 182.1 76.2 6.3e-08 32.6 0.3 10.8 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 T088569_3 - 4.4e-39 130.6 82.5 3.2e-05 24.0 1.6 10.0 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T088569_3 - 7.7e-16 57.3 80.0 0.002 18.6 0.7 10.3 9 0 0 9 9 9 8 C2H2-type zinc finger FAM178 PF14816.4 T088569_3 - 0.0077 15.1 1.1 2 7.2 0.1 2.9 3 1 1 4 4 4 2 Family of unknown function, FAM178 zf-C2H2_6 PF13912.4 T088569_3 - 0.02 14.7 0.5 0.02 14.7 0.5 9.1 9 0 0 9 9 9 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T088569_3 - 0.055 13.5 49.7 0.46 10.5 3.9 6.5 2 1 6 8 8 8 0 Zinc ribbon domain XPA_N PF01286.16 T088569_3 - 0.13 12.2 40.4 1.9 8.4 0.7 8.7 8 0 0 8 8 8 0 XPA protein N-terminal zf-C2H2_11 PF16622.3 T088569_3 - 0.2 11.3 0.0 0.2 11.3 0.0 8.5 8 0 0 8 8 8 0 zinc-finger C2H2-type DZR PF12773.5 T088569_3 - 2.9 7.9 44.3 1.2e+02 2.7 13.6 6.0 1 1 1 2 2 2 0 Double zinc ribbon zf-H2C2_2 PF13465.4 T008822_2 - 7e-102 329.6 137.9 7e-08 32.4 1.1 18.4 17 0 0 17 17 17 16 Zinc-finger double domain zf-C2H2 PF00096.24 T008822_2 - 2.3e-60 197.7 156.4 3.3e-05 24.0 0.3 18.8 19 0 0 19 19 19 16 Zinc finger, C2H2 type KRAB PF01352.25 T008822_2 - 6.4e-44 147.2 5.4 1.4e-22 79.0 0.8 2.8 3 0 0 3 3 3 2 KRAB box zf-C2H2_4 PF13894.4 T008822_2 - 1.1e-27 94.1 138.2 0.069 13.9 1.2 18.9 17 0 0 17 17 17 15 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T008822_2 - 0.0023 17.9 82.1 1.2 9.1 0.9 10.6 4 2 10 14 14 14 9 Zinc ribbon domain SCAN PF02023.15 T008822_2 - 0.03 14.0 0.0 0.063 13.0 0.0 1.5 1 0 0 1 1 1 0 SCAN domain zf-C2H2_6 PF13912.4 T008822_2 - 0.052 13.4 108.7 0.15 11.9 3.6 17.4 19 0 0 19 19 19 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T008822_2 - 4.1 8.1 70.7 2.3 8.9 3.3 8.9 2 2 3 7 7 7 0 zinc-ribbon family Exo5 PF09810.7 T008822_3 - 1.3e-54 185.9 0.9 2.4e-26 93.0 0.0 3.1 1 1 2 3 3 3 3 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.5 T008822_3 - 6.8e-05 22.7 0.0 0.0001 22.2 0.0 1.2 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily WD40 PF00400.30 T316161_1 - 5.6e-13 49.0 2.9 2.8e-07 31.0 0.3 4.4 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T316161_1 - 0.06 13.5 0.3 0.72 10.1 0.0 2.5 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 T316161_2 - 2.1e-08 34.5 0.1 0.0051 17.5 0.0 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat KIND PF16474.3 T051654_3 - 0.0012 18.7 0.0 0.0017 18.2 0.0 1.2 1 0 0 1 1 1 1 Kinase non-catalytic C-lobe domain MRG PF05712.11 T378156_1 - 1.3e-52 177.8 0.4 1.9e-52 177.3 0.4 1.2 1 0 0 1 1 1 1 MRG Ank_5 PF13857.4 T338683_1 - 1.4e-101 330.6 43.7 3.7e-12 46.1 0.4 14.6 5 5 9 14 14 14 14 Ankyrin repeats (many copies) Ank PF00023.28 T338683_1 - 5.7e-100 323.6 52.6 2.5e-07 30.7 0.1 18.3 18 0 0 18 18 18 16 Ankyrin repeat Ank_2 PF12796.5 T338683_1 - 1.1e-98 323.8 35.4 5.2e-15 55.7 0.3 10.7 4 4 6 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T338683_1 - 1.8e-95 312.0 27.9 1.2e-12 48.0 0.2 13.6 9 4 8 17 17 17 15 Ankyrin repeats (many copies) Ank_3 PF13606.4 T338683_1 - 3.7e-84 266.4 33.9 3e-06 27.0 0.1 18.0 18 0 0 18 18 18 15 Ankyrin repeat PARP PF00644.18 T338683_1 - 7.5e-24 84.4 0.2 1.5e-23 83.4 0.2 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SAM_2 PF07647.15 T338683_1 - 4.5e-14 52.2 0.4 9.8e-14 51.1 0.4 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 T338683_1 - 9.2e-12 45.1 0.5 1.8e-11 44.1 0.5 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EF1G PF00647.17 T060121_1 - 1.6e-52 175.9 0.3 2.5e-52 175.3 0.3 1.3 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.18 T060121_1 - 1.7e-22 79.4 0.0 3.1e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 T060121_1 - 2.2e-18 66.1 0.0 2.2e-18 66.1 0.0 2.3 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 T060121_1 - 5e-09 35.8 0.0 1.2e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 T060121_1 - 4.5e-06 26.6 0.0 1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 T060121_1 - 8.5e-06 25.9 0.0 1.8e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 T060121_1 - 0.0065 16.6 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain RRM_1 PF00076.20 T060121_2 - 4.1e-05 23.2 0.0 6.4e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 T060121_2 - 0.065 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif Cpn60_TCP1 PF00118.22 T270745_3 - 2.6e-17 62.5 0.1 6e-10 38.2 0.1 2.1 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family Sprouty PF05210.11 T382742_2 - 8.9e-32 109.6 30.5 8.9e-32 109.6 30.5 1.8 2 0 0 2 2 2 1 Sprouty protein (Spry) CRAL_TRIO PF00650.18 T232101_3 - 2.9e-34 118.0 0.0 4e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.4 T232101_3 - 1.5e-05 25.0 0.0 2.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.13 T232101_3 - 0.012 15.6 0.1 0.03 14.4 0.1 1.6 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain DUF1394 PF07159.10 T351718_1 - 8.1e-151 501.3 0.2 9.9e-151 501.0 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Ras PF00071.20 T022223_1 - 1e-41 142.1 0.0 1.4e-41 141.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T022223_1 - 1.4e-09 38.1 0.0 2.3e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T022223_1 - 0.0086 15.4 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family C2 PF00168.28 T154627_2 - 2.6e-12 46.8 0.0 6.3e-11 42.4 0.0 2.7 1 1 0 1 1 1 1 C2 domain Membr_traf_MHD PF10540.7 T154627_2 - 1.4e-07 31.8 0.7 2.9e-07 30.8 0.7 1.5 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain GRAM PF02893.18 T154627_3 - 5.5e-14 51.8 0.0 8.3e-14 51.3 0.0 1.2 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.6 T154627_3 - 0.002 18.1 0.0 0.0035 17.4 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 MFS_1 PF07690.14 T226922_1 - 1.6e-33 116.0 26.7 2.3e-29 102.3 17.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily IQ PF00612.25 T086795_1 - 0.00011 21.6 0.3 0.00025 20.4 0.3 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif G-alpha PF00503.18 T086795_1 - 0.36 9.8 2.8 0.53 9.3 2.8 1.2 1 0 0 1 1 1 0 G-protein alpha subunit TSP_1 PF00090.17 T123489_1 - 1.1e-26 92.6 71.1 5.1e-11 42.5 7.6 6.4 5 0 0 5 5 5 4 Thrombospondin type 1 domain Reprolysin PF01421.17 T123489_1 - 3.5e-20 72.6 0.9 8.2e-16 58.4 0.3 2.2 2 0 0 2 2 2 2 Reprolysin (M12B) family zinc metalloprotease ADAM_spacer1 PF05986.12 T123489_1 - 9e-14 51.4 0.0 1.5e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin_5 PF13688.4 T123489_1 - 6.3e-13 49.2 1.6 1.8e-12 47.7 1.6 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T123489_1 - 1.6e-09 38.2 0.0 3.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 T123489_1 - 2.3e-07 30.7 0.9 6.1e-07 29.4 0.9 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T123489_1 - 1.3e-05 24.8 0.2 1.3e-05 24.8 0.2 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.9 T123489_1 - 2.3e-05 24.9 10.7 2.3e-05 24.9 10.7 3.4 3 0 0 3 3 3 1 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.22 T123489_1 - 0.0027 17.5 0.1 0.0048 16.6 0.1 1.3 1 0 0 1 1 1 1 Matrixin DUF4953 PF16313.3 T123489_1 - 0.14 11.2 0.3 0.2 10.7 0.3 1.1 1 0 0 1 1 1 0 Met-zincin Bradykinin PF06753.10 T317992_1 - 0.08 12.5 11.5 1.5 8.5 1.1 3.8 2 0 0 2 2 2 0 Bradykinin Fascin PF06268.11 T317992_2 - 5.7e-125 409.5 0.5 1.7e-34 118.2 0.0 4.2 4 0 0 4 4 4 4 Fascin domain FRG1 PF06229.10 T317992_2 - 6.8e-15 55.2 0.0 0.005 16.4 0.0 5.3 3 3 3 6 6 6 6 FRG1-like domain Copine PF07002.14 T237596_2 - 8.3e-62 208.3 0.0 1e-61 208.0 0.0 1.1 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.7 T237596_2 - 5.9e-06 26.4 0.0 8.7e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 vWA found in TerF C terminus C2 PF00168.28 T237596_3 - 5.7e-24 84.3 0.1 2.4e-13 50.1 0.1 2.2 2 0 0 2 2 2 2 C2 domain VCBS PF13517.4 T237596_3 - 0.021 15.3 0.4 0.046 14.2 0.4 1.6 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Glyco_transf_29 PF00777.16 T246655_2 - 2e-56 191.2 0.0 2.8e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) RhoGEF PF00621.18 T121365_1 - 8.1e-30 104.3 3.0 8.1e-30 104.3 3.0 2.5 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.27 T121365_1 - 4.6e-06 27.0 0.0 1.7e-05 25.1 0.0 2.0 1 0 0 1 1 1 1 PH domain C1_1 PF00130.20 T121365_1 - 3.2e-05 23.6 3.7 8.8e-05 22.2 3.7 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RII_binding_1 PF10522.7 T121365_1 - 0.00048 19.9 1.1 0.0013 18.6 1.1 1.8 1 0 0 1 1 1 1 RII binding domain Prok-RING_1 PF14446.4 T121365_1 - 0.0029 17.4 3.3 0.0076 16.0 3.3 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 C1_2 PF03107.14 T121365_1 - 0.032 14.4 2.2 0.12 12.6 2.2 2.0 1 0 0 1 1 1 0 C1 domain zf-C2H2 PF00096.24 T380783_2 - 1.1e-09 38.1 12.9 7.1e-06 26.1 3.0 3.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T380783_2 - 8.1e-06 25.9 17.3 0.0029 17.8 5.1 4.2 3 0 0 3 3 3 3 Zinc-finger double domain zf-met PF12874.5 T380783_2 - 0.00083 19.5 1.2 0.00083 19.5 1.2 3.4 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 T380783_2 - 0.0009 19.7 15.6 0.0033 18.0 1.8 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T380783_2 - 0.0009 19.0 1.1 0.003 17.3 1.1 2.0 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T380783_2 - 0.0012 19.0 7.5 0.017 15.3 0.2 3.7 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding SNF PF00209.16 T009673_1 - 4.5e-12 45.3 1.1 5.9e-12 44.9 1.1 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.16 T009673_2 - 7.2e-189 628.7 24.0 1e-188 628.2 24.0 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family OCD_Mu_crystall PF02423.13 T128543_3 - 5.7e-111 370.3 0.4 6.8e-111 370.1 0.4 1.0 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.18 T128543_3 - 2.5e-10 40.4 0.0 3.7e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.15 T128543_3 - 0.00016 22.1 0.0 0.00037 20.9 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.13 T128543_3 - 0.00025 21.1 0.3 0.00057 20.0 0.3 1.7 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase OTCace PF00185.22 T128543_3 - 0.076 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Ceramidase PF05875.10 T167004_3 - 5e-09 35.8 2.3 7e-09 35.4 2.3 1.1 1 0 0 1 1 1 1 Ceramidase 7tm_1 PF00001.19 T045500_2 - 5e-55 186.5 15.3 9.7e-55 185.5 15.3 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LIM PF00412.20 T045500_2 - 1.4e-35 121.1 31.9 1.3e-13 50.8 4.8 3.5 3 0 0 3 3 3 3 LIM domain DUF4749 PF15936.3 T045500_2 - 3.4e-20 72.9 0.1 6.9e-20 71.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.22 T045500_2 - 3.8e-15 55.9 0.0 6.3e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) 7TM_GPCR_Srsx PF10320.7 T045500_2 - 3e-09 36.5 10.3 5.5e-09 35.6 10.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PDZ_2 PF13180.4 T045500_2 - 0.00076 19.6 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain RhoGEF PF00621.18 T022265_1 - 3.1e-29 102.4 0.3 4.6e-29 101.8 0.3 1.2 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 T022265_1 - 0.00042 20.6 0.0 0.00084 19.7 0.0 1.5 1 0 0 1 1 1 1 PH domain Peptidase_M22 PF00814.23 T100381_2 - 2.5e-41 142.1 0.0 3.2e-41 141.7 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.13 T100381_2 - 0.23 11.0 0.0 0.33 10.4 0.0 1.1 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus CD20 PF04103.13 T059480_1 - 4.6e-32 111.1 13.9 7.2e-32 110.5 13.9 1.3 1 0 0 1 1 1 1 CD20-like family E1-E2_ATPase PF00122.18 T059480_1 - 0.048 12.8 3.5 2.5 7.2 0.1 2.2 2 0 0 2 2 2 0 E1-E2 ATPase DUF3040 PF11239.6 T059480_1 - 0.19 11.9 1.4 2.4 8.4 0.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) Tetraspannin PF00335.18 T059480_1 - 3.2 7.4 12.0 0.13 11.9 3.6 2.2 1 1 2 3 3 3 0 Tetraspanin family RhoGEF PF00621.18 T121361_3 - 7.4e-30 104.4 3.0 7.4e-30 104.4 3.0 2.5 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.27 T121361_3 - 4e-06 27.2 0.0 1.5e-05 25.3 0.0 2.1 1 0 0 1 1 1 1 PH domain C1_1 PF00130.20 T121361_3 - 2.9e-05 23.7 3.7 8.1e-05 22.3 3.7 1.9 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RII_binding_1 PF10522.7 T121361_3 - 0.00044 20.0 1.1 0.0012 18.7 1.1 1.8 1 0 0 1 1 1 1 RII binding domain Prok-RING_1 PF14446.4 T121361_3 - 0.0026 17.5 3.3 0.007 16.1 3.3 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 C1_2 PF03107.14 T121361_3 - 0.029 14.6 2.2 0.11 12.7 2.2 2.1 1 0 0 1 1 1 0 C1 domain MFS_1 PF07690.14 T259766_2 - 5.5e-10 38.6 9.3 5.5e-10 38.6 9.3 2.6 3 0 0 3 3 3 2 Major Facilitator Superfamily MFS_1 PF07690.14 T259766_3 - 5.2e-07 28.8 4.0 7.9e-07 28.2 4.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 T259766_3 - 0.017 13.8 1.1 0.024 13.3 1.1 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter UPF0172 PF03665.11 T101656_2 - 3.3e-55 187.0 0.0 4.7e-55 186.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) PA28_beta PF02252.16 T101656_2 - 6.9e-53 178.1 0.0 9.6e-53 177.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.16 T101656_2 - 1e-23 83.1 0.5 1e-23 83.1 0.5 1.7 2 0 0 2 2 2 1 Proteasome activator pa28 alpha subunit RWD PF05773.20 T015677_1 - 2.2e-11 43.9 0.1 3.8e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 RWD domain AMP-binding PF00501.26 T128390_1 - 2.6e-33 115.1 0.8 1.5e-22 79.7 0.1 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.4 T128390_1 - 5.9e-26 91.1 0.7 9.6e-26 90.5 0.7 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SRI PF08236.9 T128390_1 - 0.00075 19.5 0.7 0.0012 18.8 0.7 1.3 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain NUDIX PF00293.26 T270775_3 - 2.3e-17 63.1 0.0 3.4e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain TMEM190 PF15431.4 T198488_1 - 0.012 15.6 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 190 GAPT PF11770.6 T198488_1 - 0.095 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) SCAN PF02023.15 T160830_1 - 1.4e-41 140.1 1.8 2.4e-41 139.3 1.8 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 T160830_1 - 2.6e-15 55.8 13.9 3.2e-06 27.1 4.6 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T160830_1 - 1.3e-12 47.4 18.6 6.6e-07 29.4 1.7 4.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 T160830_1 - 3.1e-05 24.3 22.2 0.015 15.9 2.7 4.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T160830_1 - 0.0017 18.1 11.6 1 9.3 0.0 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T160830_1 - 0.027 14.4 5.8 0.95 9.5 1.2 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T160830_1 - 0.94 9.7 5.6 3.6 7.9 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T160830_1 - 1 10.0 6.0 0.94 10.1 1.0 2.9 1 1 1 2 2 2 0 zinc-ribbon family XPA_N PF01286.16 T160830_1 - 1.8 8.5 17.4 2.1 8.3 1.2 4.4 4 0 0 4 4 4 0 XPA protein N-terminal XTBD PF11952.6 T275365_3 - 4.1e-30 103.2 0.0 4.1e-29 100.0 0.0 2.2 2 0 0 2 2 2 1 XRN-Two Binding Domain, XTBD Ish1 PF10281.7 T275365_3 - 0.11 12.7 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein SCAN PF02023.15 T140234_1 - 4.8e-41 138.4 3.0 1e-40 137.3 3.0 1.6 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 T140234_1 - 5.5e-34 115.0 33.8 2.8e-08 33.7 0.4 6.7 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 T140234_1 - 3.7e-26 89.9 29.4 8.7e-07 28.9 1.0 5.6 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T140234_1 - 1.6e-12 47.0 30.4 0.0045 17.6 0.7 5.9 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T140234_1 - 1.7e-09 37.3 24.3 0.17 11.7 0.7 5.7 5 0 0 5 5 5 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T140234_1 - 0.00011 22.1 19.4 0.018 15.1 3.1 3.8 2 1 1 3 3 3 2 Zinc ribbon domain XPA_N PF01286.16 T140234_1 - 0.0025 17.7 21.8 0.24 11.3 0.4 5.3 5 0 0 5 5 5 2 XPA protein N-terminal zf-trcl PF13451.4 T140234_1 - 0.016 15.0 16.4 10 6.0 0.1 5.3 5 0 0 5 5 5 0 Probable zinc-ribbon domain DZR PF12773.5 T140234_1 - 0.12 12.3 15.2 0.87 9.5 4.9 3.2 1 1 1 2 2 2 0 Double zinc ribbon HypA PF01155.17 T140234_1 - 0.19 11.7 11.7 4.4 7.2 3.5 3.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 T140234_1 - 0.19 12.4 14.9 2.6 8.7 1.3 3.1 1 1 2 3 3 3 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 T140234_1 - 0.32 11.2 16.8 2.9 8.2 0.1 5.2 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T140234_1 - 1.1 8.9 18.1 0.19 11.3 0.3 5.2 5 0 0 5 5 5 0 zinc-finger C2H2-type DUF3268 PF11672.6 T140234_1 - 1.3 9.2 11.9 0.55 10.5 1.3 2.8 1 1 1 3 3 3 0 zinc-finger-containing domain ADK_lid PF05191.12 T140234_1 - 1.4 8.8 10.9 5 7.1 1.7 3.7 2 1 2 4 4 4 0 Adenylate kinase, active site lid YhfH PF14149.4 T140234_1 - 1.5 8.7 17.0 26 4.8 0.1 5.3 5 0 0 5 5 5 0 YhfH-like protein zf-LYAR PF08790.9 T140234_1 - 2.3 8.0 14.9 0.85 9.4 0.3 4.5 5 0 0 5 5 4 0 LYAR-type C2HC zinc finger DUF2321 PF10083.7 T140234_1 - 2.6 7.5 12.0 1.5 8.3 1.7 3.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) LIM PF00412.20 T140234_1 - 2.9 8.1 13.5 6.7 6.9 1.2 4.0 1 1 1 3 3 3 0 LIM domain CpXC PF14353.4 T140234_1 - 5.3 7.0 11.6 8.8 6.3 0.0 4.5 2 1 2 4 4 4 0 CpXC protein C1_4 PF07975.10 T140234_1 - 8.9 6.5 16.4 5 7.3 1.4 3.8 2 1 2 4 4 4 0 TFIIH C1-like domain TFIIS_C PF01096.16 T140234_1 - 9 6.1 19.1 14 5.5 0.4 5.4 5 0 0 5 5 5 0 Transcription factor S-II (TFIIS) Xylo_C PF12529.6 T150357_3 - 3.7e-67 225.4 0.0 5.1e-67 224.9 0.0 1.2 1 0 0 1 1 1 1 Xylosyltransferase C terminal Branch PF02485.19 T150357_3 - 3.3e-56 190.4 0.3 4.6e-56 189.9 0.3 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme RhoGAP PF00620.25 T171056_2 - 8.1e-49 165.2 0.0 1.6e-48 164.3 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain 7tm_1 PF00001.19 T171056_2 - 1.4e-30 106.4 9.2 2.2e-30 105.7 9.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T171056_2 - 1.3e-07 31.2 3.7 1.8e-07 30.7 3.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx C1_1 PF00130.20 T171056_2 - 9.7e-05 22.1 7.2 9.7e-05 22.1 7.2 2.6 3 0 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) 7tm_4 PF13853.4 T171056_2 - 0.00037 20.2 2.9 0.00037 20.2 2.9 1.7 2 0 0 2 2 2 1 Olfactory receptor DC_STAMP PF07782.11 T349168_3 - 2.7e-35 121.8 0.1 5.2e-35 120.9 0.1 1.5 1 0 0 1 1 1 1 DC-STAMP-like protein CAF1 PF04857.18 T291899_1 - 2e-21 76.4 0.8 1.1e-10 41.0 0.1 2.3 1 1 0 2 2 2 2 CAF1 family ribonuclease RINGv PF12906.5 T288536_2 - 0.0051 16.8 0.2 0.08 13.0 0.0 2.7 2 0 0 2 2 2 1 RING-variant domain Cortexin PF11057.6 T288536_3 - 2.5e-39 132.9 0.1 5.7e-39 131.7 0.1 1.6 1 0 0 1 1 1 1 Cortexin of kidney DUF2477 PF10631.7 T370027_1 - 9e-77 256.3 28.7 9e-77 256.3 28.7 3.6 4 0 0 4 4 4 1 Protein of unknown function (DUF2477) Na_Pi_cotrans PF02690.13 T370027_2 - 8.3e-22 77.7 8.8 1.2e-21 77.2 8.8 1.2 1 0 0 1 1 1 1 Na+/Pi-cotransporter THRAP3_BCLAF1 PF15440.4 T312003_1 - 2.8e-184 614.7 93.2 2.8e-184 614.7 93.2 2.0 2 0 0 2 2 2 1 THRAP3/BCLAF1 family GRP PF07172.9 T312003_1 - 0.15 12.7 4.9 0.39 11.3 4.9 1.6 1 0 0 1 1 1 0 Glycine rich protein family Btz PF09405.8 T312003_2 - 3.3e-05 24.0 8.3 3.3e-05 24.0 8.3 1.8 2 0 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding Mito_fiss_reg PF05308.9 T312003_3 - 5.3e-94 314.7 1.7 7.4e-94 314.3 1.7 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator Caldesmon PF02029.13 T333728_2 - 2.9e-188 626.5 87.2 3.4e-188 626.3 87.2 1.0 1 0 0 1 1 1 1 Caldesmon Cnd1 PF12717.5 T070859_1 - 9.1e-33 113.4 18.0 1.8e-26 92.9 0.1 6.4 6 1 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 T070859_1 - 1.5e-08 34.0 12.9 0.35 11.1 0.1 7.6 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.4 T070859_1 - 2.4e-07 30.9 0.1 0.021 15.1 0.1 3.5 3 0 0 3 3 2 2 HEAT repeats Adaptin_N PF01602.18 T070859_1 - 2.1e-06 26.5 11.5 0.0024 16.4 0.1 4.7 4 1 0 5 5 5 2 Adaptin N terminal region CLASP_N PF12348.6 T070859_1 - 8.1e-05 22.2 9.7 0.038 13.4 0.8 5.2 4 1 1 5 5 5 1 CLASP N terminal Cnd3 PF12719.5 T070859_1 - 0.00042 19.5 5.0 0.00044 19.4 0.4 3.2 4 0 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain DUF3013 PF11217.6 T070859_1 - 0.0021 17.8 1.4 0.004 16.9 0.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3013) RTP1_C1 PF10363.7 T070859_1 - 0.021 14.9 6.8 4.1 7.5 0.1 5.7 5 1 1 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 VHS PF00790.17 T070859_1 - 0.029 14.1 0.3 0.41 10.4 0.0 2.5 2 0 0 2 2 2 0 VHS domain Cohesin_HEAT PF12765.5 T070859_1 - 0.035 14.2 1.6 0.54 10.4 0.2 3.2 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion DUF1043 PF06295.10 T070859_1 - 0.11 12.4 0.1 0.34 10.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) HEAT_EZ PF13513.4 T070859_1 - 0.19 12.1 1.8 1.3e+02 3.1 0.0 4.4 4 0 0 4 4 4 0 HEAT-like repeat FYVE PF01363.19 T259657_3 - 1.3e-18 66.7 11.5 1.3e-18 66.7 11.5 2.7 3 0 0 3 3 3 1 FYVE zinc finger Tetraspannin PF00335.18 T294124_3 - 1.6e-54 184.8 7.9 2.2e-54 184.3 7.9 1.2 1 0 0 1 1 1 1 Tetraspanin family IF4E PF01652.16 T294124_3 - 9.4e-53 178.1 0.3 1.5e-52 177.5 0.3 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E EBP PF05241.10 T374339_1 - 3.6e-55 186.0 9.4 3.6e-55 186.0 9.4 1.5 2 0 0 2 2 2 1 Emopamil binding protein MBOAT PF03062.17 T374339_3 - 3.8e-17 62.6 11.7 6.3e-17 61.8 11.7 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family FUSC_2 PF13515.4 T374339_3 - 0.17 11.9 5.3 6.9 6.7 0.8 2.7 2 0 0 2 2 2 0 Fusaric acid resistance protein-like RVT_1 PF00078.25 T149363_1 - 1.1e-09 38.0 0.2 1.7e-09 37.4 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrin_beta PF00362.16 T149363_3 - 1.3e-111 372.1 0.1 2.5e-111 371.1 0.1 1.5 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 T149363_3 - 2.1e-21 75.2 1.3 4.1e-21 74.2 1.3 1.6 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 T149363_3 - 2.2e-21 76.0 11.2 2.2e-21 76.0 11.2 3.4 4 1 1 5 5 5 1 Integrin beta tail domain EGF_2 PF07974.11 T149363_3 - 0.0003 21.0 15.0 0.0003 21.0 15.0 6.6 7 0 0 7 7 7 3 EGF-like domain EF-hand_11 PF08976.9 T149363_3 - 0.0052 17.5 0.0 0.015 16.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.4 T149363_3 - 0.016 15.6 7.1 0.74 10.2 0.0 4.1 4 1 0 4 4 4 0 EF-hand domain pair KH_1 PF00013.27 T256306_2 - 6e-51 170.0 16.5 2.4e-13 49.5 0.4 4.6 4 0 0 4 4 4 4 KH domain RRM_1 PF00076.20 T256306_2 - 3e-16 58.8 0.0 1.6e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_2 PF07650.15 T256306_2 - 2e-13 49.8 6.8 0.0082 15.8 0.2 4.4 4 0 0 4 4 4 4 KH domain KH_4 PF13083.4 T256306_2 - 2.2e-10 40.1 1.2 0.0088 15.8 0.0 4.4 4 0 0 4 4 4 3 KH domain KH_5 PF13184.4 T256306_2 - 0.0075 16.2 7.0 5.1 7.1 0.1 4.0 4 0 0 4 4 4 2 NusA-like KH domain RRM_5 PF13893.4 T256306_2 - 0.013 15.0 0.0 0.83 9.1 0.0 2.3 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MOEP19 PF16005.3 T256306_2 - 0.058 13.3 0.0 1.8 8.5 0.0 2.9 3 0 0 3 3 3 0 KH-like RNA-binding domain DUF3996 PF13161.4 T182154_1 - 4.8e-05 23.0 1.3 2 8.0 0.1 4.0 2 1 1 3 3 3 3 Protein of unknown function (DUF3996) zf-H2C2_2 PF13465.4 T182154_3 - 3.6e-68 223.0 69.5 1.3e-08 34.8 0.4 12.7 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2 PF00096.24 T182154_3 - 3.7e-51 168.7 85.4 6.3e-06 26.2 1.9 12.3 12 0 0 12 12 10 10 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 T182154_3 - 8.5e-29 98.8 71.5 0.01 15.6 0.4 14.2 15 0 0 15 15 15 10 C2H2-type zinc finger zf-C2H2_4 PF13894.4 T182154_3 - 2.8e-26 89.8 85.3 0.0034 18.0 0.8 12.9 12 0 0 12 12 11 10 C2H2-type zinc finger KRAB PF01352.25 T182154_3 - 2.3e-22 78.2 0.8 4.4e-22 77.3 0.8 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 T182154_3 - 5e-07 29.7 36.9 1.7 8.9 0.2 10.7 11 0 0 11 11 10 3 Zinc-finger double-stranded RNA-binding C1_1 PF00130.20 T182154_3 - 1.3e-05 24.8 25.2 1.2 8.9 0.1 7.7 1 1 3 7 7 7 4 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.5 T182154_3 - 0.0016 18.3 37.5 8.1 6.4 4.8 6.0 1 1 1 2 2 1 1 Double zinc ribbon Zn-ribbon_8 PF09723.8 T182154_3 - 0.0018 18.2 52.0 1.1 9.3 2.6 7.5 2 1 6 9 9 9 5 Zinc ribbon domain zinc_ribbon_15 PF17032.3 T182154_3 - 0.0033 18.0 34.2 2.8 8.6 1.1 5.9 1 1 3 5 5 5 5 zinc-ribbon family XPA_N PF01286.16 T182154_3 - 0.015 15.2 44.0 3.2 7.7 0.7 10.8 10 0 0 10 10 10 0 XPA protein N-terminal zf-C2H2_11 PF16622.3 T182154_3 - 0.022 14.4 60.4 0.72 9.5 0.6 10.7 10 0 0 10 10 10 0 zinc-finger C2H2-type ADK_lid PF05191.12 T182154_3 - 2.9 7.9 21.1 1.9 8.5 1.2 5.8 3 2 3 6 6 6 0 Adenylate kinase, active site lid HCO3_cotransp PF00955.19 T191989_1 - 2.5e-222 739.2 6.7 3e-222 738.9 6.7 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 T191989_1 - 7.2e-104 347.2 0.0 1e-103 346.7 0.0 1.2 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Xan_ur_permease PF00860.18 T191989_1 - 0.26 9.8 8.6 0.087 11.4 0.6 2.2 2 0 0 2 2 2 0 Permease family Dynactin PF12455.6 T191989_2 - 2.8e-101 338.4 4.9 2.8e-101 338.4 4.9 3.3 4 0 0 4 4 4 1 Dynein associated protein CAP_GLY PF01302.23 T191989_2 - 4.9e-22 77.6 2.4 8.8e-22 76.8 2.4 1.4 1 0 0 1 1 1 1 CAP-Gly domain Fe_hyd_lg_C PF02906.12 T191989_2 - 1.3 8.5 4.2 3.3 7.2 4.2 1.7 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain RIC3 PF15361.4 T054329_2 - 1e-34 119.9 0.0 1.7e-34 119.1 0.0 1.4 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 InaF-motif PF15018.4 T177870_1 - 5.3e-13 48.4 4.3 1e-12 47.6 4.3 1.5 1 0 0 1 1 1 1 TRP-interacting helix DUF4594 PF15266.4 T177870_2 - 4.1e-58 196.6 25.9 4.1e-58 196.6 25.9 2.9 3 1 1 4 4 4 1 Domain of unknown function (DUF4594) DUF4596 PF15363.4 T167378_2 - 1.6e-23 82.5 1.6 1.6e-23 82.5 1.6 3.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4596) DUF1725 PF08333.9 T135894_1 - 0.0071 15.8 0.1 0.014 14.9 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1338 PF07063.11 T135894_3 - 0.01 14.9 2.8 0.017 14.2 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1338) P2_Phage_GpR PF06891.9 T135894_3 - 0.53 10.3 3.2 0.38 10.7 1.2 1.8 2 0 0 2 2 2 0 P2 phage tail completion protein R (GpR) Reo_sigmaC PF04582.10 T135894_3 - 1.6 7.9 8.8 0.11 11.8 1.2 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Homeobox PF00046.27 T203374_1 - 1.4e-56 188.0 35.9 5.9e-19 67.5 5.8 3.4 3 0 0 3 3 3 3 Homeobox domain Hox9_act PF04617.11 T203374_1 - 2.1e-47 162.2 0.5 2.1e-47 162.2 0.5 3.1 3 1 1 4 4 4 1 Hox9 activation region DUF3528 PF12045.6 T203374_1 - 6.8e-39 133.6 0.0 2.4e-20 73.5 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3528) Homeobox_KN PF05920.9 T203374_1 - 0.006 16.3 11.9 1.2 9.0 0.3 3.8 3 0 0 3 3 3 3 Homeobox KN domain HTH_23 PF13384.4 T203374_1 - 0.15 11.7 1.4 1.5 8.6 0.0 3.0 3 0 0 3 3 3 0 Homeodomain-like domain Homez PF11569.6 T203374_1 - 1.1 8.6 4.5 18 4.7 0.2 3.3 3 0 0 3 3 3 0 Homeodomain leucine-zipper encoding, Homez Homeobox PF00046.27 T203374_3 - 2.3e-17 62.4 10.5 4.3e-17 61.5 10.5 1.5 1 0 0 1 1 1 1 Homeobox domain RanGAP1_C PF07834.9 T234272_1 - 6.7e-74 247.2 0.2 6.7e-74 247.2 0.2 1.5 2 0 0 2 2 1 1 RanGAP1 C-terminal domain LRR_6 PF13516.4 T234272_1 - 1.5e-14 52.6 3.2 0.26 11.3 0.0 8.7 9 0 0 9 9 9 4 Leucine Rich repeat LRR_4 PF12799.5 T234272_1 - 8.8e-05 22.6 3.0 3.6 8.0 0.0 5.0 4 1 2 6 6 6 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T234272_1 - 0.0004 19.9 0.1 1.9 8.2 0.0 4.4 4 1 0 4 4 4 1 Leucine rich repeat SDA1 PF05285.10 T234272_1 - 0.00069 19.0 12.6 0.0012 18.3 12.6 1.2 1 0 0 1 1 1 1 SDA1 CPSF100_C PF13299.4 T234272_1 - 0.0071 16.4 7.6 0.012 15.7 7.6 1.3 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Nop14 PF04147.10 T234272_1 - 0.02 13.0 17.1 0.031 12.4 17.1 1.2 1 0 0 1 1 1 0 Nop14-like family LRR_1 PF00560.31 T234272_1 - 0.022 15.0 1.4 72 4.3 0.0 5.4 5 0 0 5 5 5 0 Leucine Rich Repeat IFN-gamma PF00714.15 T234272_1 - 0.025 14.3 0.2 0.044 13.5 0.2 1.3 1 0 0 1 1 1 0 Interferon gamma SpoIIP PF07454.9 T234272_1 - 0.12 11.6 5.7 0.2 11.0 5.7 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4471 PF14740.4 T234272_1 - 0.16 11.0 0.3 0.24 10.4 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) CobT PF06213.10 T234272_1 - 0.2 10.9 23.6 0.4 9.9 23.6 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Mpp10 PF04006.10 T234272_1 - 0.22 9.8 20.5 0.32 9.3 20.5 1.1 1 0 0 1 1 1 0 Mpp10 protein DUF2052 PF09747.7 T234272_1 - 0.27 11.2 16.3 0.44 10.5 16.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DNA_pol_phi PF04931.11 T234272_1 - 0.28 9.1 25.9 0.42 8.5 25.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4820 PF16091.3 T234272_1 - 0.4 9.9 1.9 0.68 9.1 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) BUD22 PF09073.8 T234272_1 - 0.4 9.8 17.8 0.67 9.1 17.8 1.2 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.15 T234272_1 - 0.51 8.9 2.8 0.73 8.4 2.8 1.1 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.12 T234272_1 - 0.6 10.4 5.5 1 9.7 5.5 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 PI3K_1B_p101 PF10486.7 T234272_1 - 0.92 7.1 4.1 1.3 6.5 4.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.12 T234272_1 - 1.2 7.2 15.2 1.7 6.7 15.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.6 T234272_1 - 1.3 7.5 7.5 2 7.0 7.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Paf1 PF03985.11 T234272_1 - 2.1 7.1 23.6 3 6.6 23.6 1.1 1 0 0 1 1 1 0 Paf1 Cnd2 PF05786.12 T234272_1 - 2.2 6.6 12.9 3.1 6.2 12.9 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 THOC2_N PF16134.3 T234272_1 - 2.3 6.6 17.8 1 7.8 0.3 2.1 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus DUF1510 PF07423.9 T234272_1 - 4 6.7 20.7 6.3 6.0 20.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RNA_pol_3_Rpc31 PF11705.6 T234272_1 - 4.4 7.3 25.5 7.9 6.5 25.5 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RR_TM4-6 PF06459.10 T234272_1 - 4.5 6.9 14.1 7.3 6.2 14.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sigma70_ner PF04546.11 T234272_1 - 4.6 6.9 22.0 9.4 5.9 22.0 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Merozoite_SPAM PF07133.9 T234272_1 - 5.8 6.7 36.7 9.9 6.0 36.7 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) PPP4R2 PF09184.9 T234272_1 - 7.4 5.9 19.6 12 5.2 19.6 1.2 1 0 0 1 1 1 0 PPP4R2 XAP5 PF04921.12 T234272_1 - 7.5 6.2 10.9 12 5.5 10.9 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator NOA36 PF06524.10 T234272_1 - 8.2 5.6 19.3 14 4.8 19.3 1.3 1 0 0 1 1 1 0 NOA36 protein C1q PF00386.19 T068737_1 - 1.6e-34 118.8 0.0 2.1e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 T068737_1 - 2.7e-06 26.9 38.6 2.7e-06 26.9 38.6 2.9 2 1 0 2 2 2 1 Collagen triple helix repeat (20 copies) Fz PF01392.20 T068737_2 - 1e-22 80.8 8.4 3.5e-22 79.1 2.0 2.8 2 0 0 2 2 2 2 Fz domain CUB PF00431.18 T068737_2 - 8.9e-06 25.9 0.0 1.4e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 CUB domain Ldl_recept_a PF00057.16 T068737_2 - 9.9e-05 22.3 14.3 0.00033 20.7 10.0 2.9 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A CUB PF00431.18 T068737_3 - 1.6e-41 140.9 0.0 1.3e-21 76.8 0.0 2.2 2 0 0 2 2 2 2 CUB domain Ldl_recept_a PF00057.16 T068737_3 - 1.4e-06 28.2 8.5 3e-06 27.2 8.5 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A CUB_2 PF02408.18 T068737_3 - 0.00058 19.5 0.1 0.3 10.7 0.0 2.6 2 0 0 2 2 2 2 CUB-like domain RRM_1 PF00076.20 T005583_1 - 4.4e-14 51.9 0.0 1.3e-09 37.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Myosin_head PF00063.19 T216701_1 - 5.5e-262 870.8 0.0 1.8e-261 869.1 0.0 1.9 1 1 0 1 1 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 T216701_1 - 2.3e-146 489.2 270.4 3e-146 488.8 270.4 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 T216701_1 - 1.9e-12 46.7 3.6 3.8e-12 45.7 3.6 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 T216701_1 - 0.00025 20.4 62.0 0.0018 17.6 2.0 8.5 2 2 7 11 11 11 8 Reovirus sigma C capsid protein Filament PF00038.19 T216701_1 - 0.00049 19.6 50.4 0.00049 19.6 50.4 8.5 1 1 7 8 8 8 3 Intermediate filament protein TRAM_LAG1_CLN8 PF03798.14 T015650_1 - 1.5e-30 106.3 15.4 1.5e-30 106.3 15.4 2.3 2 0 0 2 2 2 1 TLC domain TMPIT PF07851.11 T087887_1 - 1.9e-155 516.9 16.7 2.4e-155 516.5 16.7 1.1 1 0 0 1 1 1 1 TMPIT-like protein Helo_like_N PF17111.3 T087887_1 - 0.55 9.4 3.5 0.85 8.8 3.5 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins BTB PF00651.29 T009938_3 - 1.7e-15 57.1 0.0 3e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 T009938_3 - 8.4e-11 41.8 0.2 5.5e-10 39.1 0.1 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Trypsin PF00089.24 T342964_1 - 6.3e-70 235.3 0.0 8.8e-70 234.8 0.0 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 T342964_1 - 3.4e-49 164.9 15.3 2.9e-26 91.4 2.2 2.6 2 0 0 2 2 2 2 Kringle domain EGF PF00008.25 T342964_1 - 2.8e-06 27.4 6.2 2.8e-06 27.4 6.2 3.0 3 0 0 3 3 3 1 EGF-like domain Trypsin_2 PF13365.4 T342964_1 - 6.1e-05 23.8 0.0 0.00014 22.7 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain hEGF PF12661.5 T342964_1 - 0.0018 18.8 4.8 0.013 16.0 4.8 2.7 1 0 0 1 1 1 1 Human growth factor-like EGF DUF1986 PF09342.9 T342964_1 - 0.0036 17.5 0.0 0.0058 16.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EGF_2 PF07974.11 T342964_1 - 2.6 8.3 12.7 23 5.3 12.7 2.8 1 0 0 1 1 1 0 EGF-like domain NTR PF01759.19 T178313_1 - 7.6e-23 80.2 0.0 1.2e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Laminin_EGF PF00053.22 T178313_1 - 2.8e-17 62.5 33.4 2.2e-08 34.0 10.8 2.9 2 0 0 2 2 2 2 Laminin EGF domain Laminin_EGF PF00053.22 T178313_2 - 9.8e-05 22.3 10.4 9.8e-05 22.3 10.4 2.9 2 1 0 2 2 2 1 Laminin EGF domain zf-C2H2_4 PF13894.4 T100725_3 - 8.9e-21 72.7 47.9 0.0031 18.1 0.4 8.7 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2 PF00096.24 T100725_3 - 8.4e-17 60.5 49.5 0.00043 20.5 0.4 8.2 9 0 0 9 9 8 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 T100725_3 - 3.8e-14 52.2 45.4 7.7e-07 29.2 0.2 8.2 9 0 0 9 9 8 4 Zinc-finger double domain zf-C2H2_jaz PF12171.6 T100725_3 - 8.2e-11 41.8 21.7 0.0064 16.6 0.4 6.4 8 0 0 8 8 6 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T100725_3 - 1.1e-10 41.4 36.8 0.0075 16.5 0.3 8.0 8 0 0 8 8 8 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 T100725_3 - 2.5e-08 33.5 23.7 0.00078 19.2 0.1 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_2 PF12756.5 T100725_3 - 0.0035 17.5 24.4 1.4 9.2 0.5 6.4 3 3 3 6 6 6 2 C2H2 type zinc-finger (2 copies) zf-C2H2_8 PF15909.3 T100725_3 - 0.0077 16.4 17.1 0.03 14.5 0.3 4.1 4 1 1 5 5 4 2 C2H2-type zinc ribbon zf-Di19 PF05605.10 T100725_3 - 0.044 13.9 27.1 0.3 11.2 1.6 4.8 4 2 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding NOA36 PF06524.10 T100725_3 - 0.049 12.9 0.1 0.049 12.9 0.1 2.7 3 0 0 3 3 3 0 NOA36 protein Desulfoferrod_N PF06397.10 T100725_3 - 0.36 10.4 8.6 0.95 9.0 0.5 3.7 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain zf-C2H2_11 PF16622.3 T100725_3 - 0.38 10.4 28.3 1.4 8.6 0.3 6.8 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.3 T100725_3 - 1.6 8.5 6.3 4.8 7.0 0.1 3.9 5 0 0 5 5 4 0 C2H2 type zinc-finger (1 copy) Nop14 PF04147.10 T100725_3 - 2 6.4 8.9 2.8 5.9 8.9 1.1 1 0 0 1 1 1 0 Nop14-like family Astro_capsid_p PF12226.6 T100725_3 - 2 7.4 4.9 3.2 6.7 4.9 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein BSP_II PF05432.9 T100725_3 - 2.9 7.4 15.7 5.2 6.6 15.7 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) UBZ_FAAP20 PF15750.3 T100725_3 - 3.2 7.7 7.1 0.69 9.8 0.2 3.3 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger zinc_ribbon_15 PF17032.3 T100725_3 - 7.2 7.3 11.2 33 5.2 0.2 3.8 4 0 0 4 4 3 0 zinc-ribbon family FAM176 PF14851.4 T100725_3 - 9.7 5.7 7.7 19 4.8 7.7 1.4 1 0 0 1 1 1 0 FAM176 family HECT PF00632.23 T209268_2 - 2.6e-87 293.0 0.4 6.8e-87 291.7 0.0 1.9 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) WWE PF02825.18 T209268_2 - 4.7e-19 68.6 0.1 9.5e-19 67.6 0.1 1.5 1 0 0 1 1 1 1 WWE domain UNC45-central PF11701.6 T209268_2 - 0.015 15.1 1.0 0.046 13.5 0.0 2.3 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central HEAT_2 PF13646.4 T209268_2 - 0.2 12.0 0.3 1 9.7 0.1 2.4 2 0 0 2 2 2 0 HEAT repeats Laps PF10169.7 T081538_1 - 2.8e-40 137.7 23.3 4.6e-40 137.0 23.3 1.3 1 0 0 1 1 1 1 Learning-associated protein CHDCT2 PF08074.9 T141177_1 - 2.3e-63 213.3 0.5 5.2e-63 212.2 0.5 1.6 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF1086 PF06461.9 T141177_1 - 8.2e-62 207.0 0.0 2.5e-61 205.4 0.0 1.9 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.21 T141177_1 - 3.3e-61 206.8 0.0 7.4e-61 205.7 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain CHDNT PF08073.10 T141177_1 - 2.7e-26 91.1 0.4 6.3e-26 89.9 0.4 1.7 1 0 0 1 1 1 1 CHDNT (NUC034) domain DUF1087 PF06465.11 T141177_1 - 6.4e-25 86.9 6.6 6.4e-25 86.9 6.6 2.8 3 0 0 3 3 1 1 Domain of Unknown Function (DUF1087) Helicase_C PF00271.29 T141177_1 - 1.3e-21 76.9 0.0 2.3e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 T141177_1 - 3e-20 71.7 26.4 1.8e-10 40.4 7.3 2.6 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.22 T141177_1 - 3.3e-19 68.4 6.8 9e-14 51.0 2.5 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 T141177_1 - 1.8e-08 34.4 0.0 5.2e-08 32.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 T141177_1 - 4.8e-08 32.4 0.0 1.3e-07 31.0 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 HMG_box PF00505.17 T141177_1 - 0.0035 17.6 0.2 0.0035 17.6 0.2 2.3 2 0 0 2 2 1 1 HMG (high mobility group) box DEAD PF00270.27 T141177_1 - 0.0063 16.2 0.0 0.019 14.6 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase PHD_2 PF13831.4 T141177_1 - 0.053 12.9 11.5 0.28 10.6 3.1 2.7 2 0 0 2 2 2 0 PHD-finger AAA_22 PF13401.4 T141177_1 - 0.12 12.5 0.0 0.49 10.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain DUF3140 PF11338.6 T141177_1 - 0.14 12.4 1.2 0.48 10.7 1.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) zf-PHD-like PF15446.4 T141177_1 - 4 6.9 15.8 0.98 8.9 0.7 3.1 1 1 0 2 2 2 0 PHD/FYVE-zinc-finger like domain CHDCT2 PF08074.9 T141177_2 - 8.5e-18 65.0 0.0 1.3e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain SNAP PF14938.4 T177925_2 - 8.6e-108 359.9 20.6 1.1e-107 359.5 20.6 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Calx-beta PF03160.12 T177925_2 - 1.5e-62 207.9 0.5 2.6e-31 107.6 0.0 2.2 2 0 0 2 2 2 2 Calx-beta domain Na_Ca_ex_C PF16494.3 T177925_2 - 9.2e-47 158.5 0.0 1.4e-46 157.9 0.0 1.3 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain Na_Ca_ex PF01699.22 T177925_2 - 1.3e-23 83.5 8.9 1.3e-23 83.5 8.9 2.2 2 0 0 2 2 2 1 Sodium/calcium exchanger protein TPR_12 PF13424.4 T177925_2 - 0.00022 21.3 11.0 0.038 14.2 0.8 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF4935 PF16289.3 T177925_2 - 0.11 11.3 0.1 0.16 10.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4935) TPR_7 PF13176.4 T177925_2 - 0.12 12.3 0.4 12 6.1 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Spatacsin_C PF14649.4 T177925_2 - 3.7 6.5 6.8 11 4.9 1.5 2.1 1 1 1 2 2 2 0 Spatacsin C-terminus TPR_1 PF00515.26 T177925_2 - 3.8 7.4 5.4 21 5.0 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat VCBS PF13517.4 T177925_3 - 0.0029 18.0 0.0 0.0067 16.9 0.0 1.7 1 0 0 1 1 1 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.21 T177925_3 - 0.048 13.7 0.0 17 5.5 0.0 2.6 2 0 0 2 2 2 0 FG-GAP repeat Patatin PF01734.20 T302574_2 - 0.0035 17.4 0.0 0.0062 16.6 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase SAP PF02037.25 T141971_1 - 2.5e-10 39.7 0.1 5.4e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 SAP domain RPEL PF02755.13 T141971_1 - 5.2e-09 35.4 0.2 6e-07 28.8 0.3 2.5 2 0 0 2 2 2 2 RPEL repeat IncA PF04156.12 T141971_1 - 0.015 15.0 6.0 0.028 14.1 0.1 2.4 2 0 0 2 2 2 0 IncA protein Beta-Casp PF10996.6 T000678_2 - 1.2e-25 89.7 0.1 5.9e-25 87.6 0.0 2.2 3 0 0 3 3 3 1 Beta-Casp domain Lactamase_B_6 PF16661.3 T000678_2 - 6.9e-23 81.0 0.0 1.3e-22 80.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.10 T000678_2 - 2.5e-17 62.4 0.0 4.9e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.25 T000678_2 - 4.2e-11 43.1 0.0 2e-08 34.3 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 T000678_2 - 3.9e-08 32.9 0.7 9e-08 31.7 0.1 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.4 T000678_2 - 0.00013 21.8 0.0 0.0014 18.4 0.0 2.5 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.3 T000678_2 - 0.00096 18.3 0.0 0.0018 17.4 0.0 1.4 1 0 0 1 1 1 1 Putative beta-lactamase-like family RNase_Zc3h12a PF11977.6 T375625_2 - 3.7e-63 211.8 0.0 5.6e-63 211.2 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain zf-CCCH_2 PF14608.4 T375625_2 - 7.5 7.1 9.7 42 4.7 9.7 2.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger 3Beta_HSD PF01073.17 T128795_3 - 6.4e-57 192.5 0.0 8.7e-57 192.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 T128795_3 - 5.3e-31 107.8 0.0 7.5e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.15 T128795_3 - 3e-10 39.6 0.0 4.3e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.3 T128795_3 - 3.4e-09 36.4 0.0 5e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 T128795_3 - 6.5e-09 35.2 0.0 9.9e-09 34.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 T128795_3 - 6.4e-08 32.6 0.0 9.2e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Cornifin PF02389.13 T128795_3 - 0.00011 22.2 28.0 0.00031 20.8 11.6 3.6 2 1 1 3 3 2 2 Cornifin (SPRR) family NmrA PF05368.11 T128795_3 - 0.00016 21.2 0.0 0.00024 20.6 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.23 T128795_3 - 0.00085 18.7 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 T128795_3 - 0.02 14.7 0.0 0.032 14.0 0.0 1.2 1 0 0 1 1 1 0 KR domain Pyr_redox_2 PF07992.12 T128795_3 - 0.23 10.5 0.0 0.33 10.0 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.23 T297331_3 - 1.4e-22 80.2 0.0 2.2e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T297331_3 - 0.02 14.0 1.0 0.11 11.6 1.0 1.9 1 1 0 1 1 1 0 Protein tyrosine kinase DUF4106 PF13388.4 T297331_3 - 6.1 5.8 9.0 8.6 5.3 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) BRCT_assoc PF12820.5 T148066_1 - 2.2e-81 271.4 1.3 2.2e-81 271.4 1.3 3.1 2 0 0 2 2 2 1 Serine-rich domain associated with BRCT BRCT PF00533.24 T148066_1 - 1.5e-18 66.9 0.0 8.1e-09 35.6 0.0 2.9 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-C3HC4 PF00097.23 T148066_1 - 1.8e-09 37.2 10.7 6e-09 35.5 10.7 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T148066_1 - 5.8e-09 35.5 11.1 1.7e-08 34.0 11.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T148066_1 - 1.4e-07 31.4 10.7 4.3e-07 29.8 10.7 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 T148066_1 - 4.8e-07 29.4 7.6 1.1e-06 28.2 7.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T148066_1 - 9.7e-07 28.6 9.0 3.1e-06 26.9 9.0 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 T148066_1 - 3.6e-06 27.0 8.6 3.6e-06 27.0 8.6 2.4 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 T148066_1 - 1.5e-05 24.7 8.7 4.6e-05 23.2 8.7 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.6 T148066_1 - 0.00024 20.7 7.4 0.00073 19.2 7.4 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 T148066_1 - 0.00044 19.9 2.1 0.001 18.8 2.1 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein BRCT_2 PF16589.3 T148066_1 - 0.00086 19.5 0.0 0.42 10.9 0.0 2.8 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain zf-ANAPC11 PF12861.5 T148066_1 - 0.0028 17.5 1.7 0.0063 16.4 1.7 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 T148066_1 - 0.003 17.2 9.1 0.0074 16.0 8.0 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 T148066_1 - 0.0053 16.7 7.0 0.015 15.3 7.0 1.8 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.5 T148066_1 - 0.019 15.1 5.0 0.066 13.4 5.0 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.4 T148066_1 - 0.93 9.1 7.1 2.4 7.8 7.1 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Asp-B-Hydro_N PF05279.9 T344799_3 - 1e-105 353.1 17.3 1.3e-105 352.8 17.3 1.1 1 0 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region SR-25 PF10500.7 T344799_3 - 0.34 10.4 6.2 0.62 9.5 6.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein 7tm_4 PF13853.4 T329318_1 - 4e-41 141.5 20.2 5.6e-41 141.0 20.2 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T329318_1 - 2.7e-24 85.7 14.1 4.7e-24 84.9 14.1 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 T329318_1 - 0.011 15.0 20.5 0.023 13.9 20.5 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2294 PF10057.7 T329318_1 - 0.04 13.9 0.0 0.069 13.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) Cathelicidins PF00666.15 T335679_2 - 0.029 14.6 0.6 0.058 13.6 0.6 1.4 1 0 0 1 1 1 0 Cathelicidin Spp-24 PF07448.9 T335679_2 - 0.041 13.9 0.5 4.8 7.3 0.1 2.5 2 0 0 2 2 2 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain KH_1 PF00013.27 T079337_3 - 1.3e-46 156.2 15.8 5.1e-17 61.3 0.8 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 T079337_3 - 5.6e-12 45.2 5.4 0.00068 19.3 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 T079337_3 - 0.00056 19.6 3.8 1.1 9.1 0.3 3.2 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 T079337_3 - 0.044 13.7 6.8 4 7.5 0.1 3.2 3 0 0 3 3 3 0 NusA-like KH domain HEAT PF02985.20 T317011_3 - 1.1e-10 40.7 26.4 0.02 15.0 0.1 9.1 9 0 0 9 9 9 4 HEAT repeat HEAT_2 PF13646.4 T317011_3 - 1.3e-09 38.1 21.9 3.3e-06 27.3 0.0 6.3 5 2 2 7 7 7 3 HEAT repeats Cnd1 PF12717.5 T317011_3 - 3.9e-05 23.6 0.1 0.032 14.1 0.0 3.8 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.5 T317011_3 - 0.00023 21.6 0.0 0.16 12.5 0.0 3.6 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.4 T317011_3 - 1.2 9.5 49.7 0.22 11.9 0.0 9.7 6 2 5 11 11 11 0 HEAT-like repeat Med19 PF10278.7 T317011_3 - 4 7.2 6.4 7.5 6.3 6.4 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 zf-H2C2_2 PF13465.4 T300052_2 - 5.4e-87 282.5 100.8 1.1e-08 35.1 0.3 14.9 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 T300052_2 - 4.7e-45 149.5 129.0 1.2e-05 25.4 0.1 16.1 16 0 0 16 16 16 14 Zinc finger, C2H2 type KRAB PF01352.25 T300052_2 - 3.2e-23 81.0 0.3 7.1e-23 79.9 0.3 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T300052_2 - 1.9e-22 77.9 114.6 0.0034 17.9 3.2 15.5 15 0 0 15 15 15 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T300052_2 - 7.3e-15 54.4 92.2 0.00025 20.8 0.2 14.7 14 0 0 14 14 14 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T300052_2 - 0.00025 21.0 76.1 0.034 14.1 1.9 9.0 5 2 5 10 10 10 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T300052_2 - 0.00026 21.1 49.8 0.21 11.8 0.0 10.4 10 1 1 11 11 11 5 Zinc-finger double-stranded RNA-binding Zona_pellucida PF00100.21 T247148_2 - 1.2e-40 139.8 1.6 1.7e-40 139.2 1.6 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain CARD_2 PF16739.3 T202011_2 - 8.1e-48 160.2 0.9 5.8e-23 80.6 0.7 2.4 2 0 0 2 2 2 2 Caspase recruitment domain CARD PF00619.19 T202011_2 - 2e-14 53.2 1.6 7.7e-13 48.2 1.5 2.4 2 0 0 2 2 2 1 Caspase recruitment domain LRR_6 PF13516.4 T047804_2 - 7.1e-07 28.7 1.1 1.2 9.3 0.1 6.1 6 0 0 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.5 T047804_2 - 2.6e-06 27.5 0.0 0.24 11.7 0.0 3.3 2 1 2 4 4 4 2 Leucine Rich repeats (2 copies) F-box PF00646.31 T047804_2 - 4.7e-06 26.2 2.1 1.3e-05 24.8 2.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 T047804_2 - 0.029 14.1 1.2 0.078 12.7 1.2 1.8 1 0 0 1 1 1 0 F-box-like Beach PF02138.16 T267562_3 - 1.5e-127 424.6 0.1 2.4e-127 423.9 0.1 1.3 1 0 0 1 1 1 1 Beige/BEACH domain FYVE PF01363.19 T267562_3 - 1.9e-17 63.0 12.3 1.9e-17 63.0 12.3 2.6 2 0 0 2 2 2 1 FYVE zinc finger PH_BEACH PF14844.4 T267562_3 - 6.8e-12 45.2 0.0 1.7e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4704 PF15787.3 T267562_3 - 4.9e-07 29.1 5.3 1e-06 28.1 1.8 3.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4704) WD40 PF00400.30 T267562_3 - 7.8e-05 23.3 12.7 0.04 14.7 0.3 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat Laminin_G_3 PF13385.4 T267562_3 - 0.0012 18.9 0.0 0.0034 17.4 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF4800 PF16057.3 T267562_3 - 0.0018 17.4 0.8 0.0036 16.5 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) E3_UbLigase_R4 PF13764.4 T267562_3 - 0.041 11.9 0.2 0.088 10.8 0.2 1.5 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 STIL_N PF15253.4 T010523_3 - 7.9e-177 588.1 0.8 3.9e-113 378.3 0.4 2.3 1 1 1 2 2 2 2 SCL-interrupting locus protein N-terminus UCH PF00443.27 T043987_3 - 8.2e-21 74.5 1.3 9.8e-21 74.3 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 T043987_3 - 1.7e-06 27.8 1.8 4e-06 26.6 1.8 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-H2C2_2 PF13465.4 T206957_2 - 5.7e-11 42.2 27.0 8e-07 29.1 2.8 5.9 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 T206957_2 - 4.4e-09 36.2 37.4 0.00074 19.7 1.3 6.6 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T206957_2 - 0.00021 21.7 39.4 0.0093 16.6 1.1 7.0 6 0 0 6 6 6 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 T206957_2 - 0.0029 17.2 0.9 0.0029 17.2 0.9 4.9 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 T206957_2 - 6.3 6.7 27.2 0.48 10.3 5.6 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger FMO-like PF00743.17 T025022_3 - 1.7e-79 267.6 2.9 6.6e-58 196.3 0.1 2.1 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 T025022_3 - 4.5e-09 35.8 0.0 4.8e-08 32.5 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 T025022_3 - 3.4e-06 27.1 0.0 7.7e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.17 T025022_3 - 4.9e-05 22.6 0.0 0.02 14.1 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.25 T025022_3 - 0.00028 21.2 0.2 0.073 13.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 T025022_3 - 0.00041 19.6 0.0 0.033 13.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 T025022_3 - 0.0011 18.0 0.0 0.0052 15.8 0.0 1.8 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) IlvN PF07991.10 T025022_3 - 0.0042 16.5 0.0 0.029 13.8 0.0 1.9 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.18 T025022_3 - 0.0091 15.9 0.0 0.24 11.3 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase DAO PF01266.22 T025022_3 - 0.014 14.9 0.0 0.18 11.3 0.0 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.19 T025022_3 - 0.016 14.4 0.0 0.13 11.4 0.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 T025022_3 - 0.058 12.5 0.0 1.4 8.0 0.0 2.0 2 0 0 2 2 2 0 Thi4 family Peptidase_M17_N PF02789.15 T025022_3 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain RRM_1 PF00076.20 T174005_1 - 0.00063 19.4 0.0 0.001 18.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.22 T174005_3 - 2.2e-05 24.1 8.7 0.035 13.9 0.5 2.9 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PITH PF06201.11 T162651_1 - 1.3e-39 135.7 0.1 1.8e-39 135.2 0.1 1.2 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.18 T162651_1 - 9.2e-16 57.5 0.0 1.6e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Myosin_head PF00063.19 T154458_2 - 2e-49 168.3 0.0 2.5e-49 168.0 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.15 T154458_2 - 1.1e-19 70.8 0.7 2.2e-19 69.8 0.1 1.8 2 0 0 2 2 2 1 MyTH4 domain SH3_2 PF07653.15 T154458_2 - 7.7e-10 38.2 0.0 1.6e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 T154458_2 - 1.9e-07 30.7 0.0 2.3e-06 27.2 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain IQ PF00612.25 T154458_2 - 0.83 9.5 3.7 3.4 7.6 3.7 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif Myosin_head PF00063.19 T154458_3 - 5.4e-76 256.1 0.0 8e-76 255.6 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.15 T154458_3 - 1.3e-25 89.8 0.0 1.3e-25 89.8 0.0 2.3 3 0 0 3 3 3 1 MyTH4 domain FERM_M PF00373.16 T154458_3 - 9.4e-15 54.9 0.2 9.4e-15 54.9 0.2 1.7 2 0 0 2 2 2 1 FERM central domain BACK PF07707.13 T010029_1 - 0.00024 21.0 0.0 0.0004 20.3 0.0 1.2 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 T010029_3 - 3.4e-12 46.4 0.0 8.5e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain C2 PF00168.28 T065177_2 - 1.2e-34 118.6 2.2 5.5e-20 71.4 0.5 3.2 3 0 0 3 3 3 2 C2 domain MSC PF09402.8 T065177_2 - 0.086 12.2 2.2 0.17 11.3 0.3 2.3 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain 2OG-FeII_Oxy_2 PF13532.4 T174182_1 - 1.5e-12 48.1 0.0 3.5e-12 46.8 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily KASH PF10541.7 T174182_1 - 1.2e-11 44.5 6.1 3.7e-11 43.0 6.1 1.9 1 0 0 1 1 1 1 Nuclear envelope localisation domain CAP_GLY PF01302.23 T174182_3 - 6.2e-48 160.5 3.2 5.8e-23 80.5 0.1 2.4 2 0 0 2 2 2 2 CAP-Gly domain Ank_2 PF12796.5 T174182_3 - 6.5e-10 39.3 0.6 1.4e-07 31.9 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) THAP PF05485.10 T174182_3 - 9.3e-07 29.6 1.3 1.3e-06 29.1 0.2 1.9 2 0 0 2 2 2 1 THAP domain Ank_4 PF13637.4 T174182_3 - 1.8e-05 25.1 1.1 0.018 15.4 0.2 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 T174182_3 - 5.6e-05 23.3 6.0 0.24 11.7 0.1 3.9 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.28 T174182_3 - 6.3e-05 23.1 5.2 1.2 9.6 0.7 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.4 T174182_3 - 0.00093 19.4 2.2 14 6.5 0.3 3.8 3 0 0 3 3 3 2 Ankyrin repeat AAA_22 PF13401.4 T192161_1 - 0.00055 20.1 0.0 0.00089 19.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 T192161_1 - 0.0034 17.6 0.2 0.0088 16.3 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.4 T192161_1 - 0.014 14.9 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.4 T192161_1 - 0.018 15.2 0.0 0.029 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 T192161_1 - 0.029 14.0 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain HA2 PF04408.21 T192161_3 - 4.8e-18 65.3 0.2 8.6e-18 64.4 0.2 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) CUE PF02845.14 T192161_3 - 3.3e-09 36.1 0.0 7.8e-09 34.9 0.0 1.6 1 0 0 1 1 1 1 CUE domain OB_NTP_bind PF07717.14 T192161_3 - 3.8e-07 30.1 0.0 8.1e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold zf-H2C2_2 PF13465.4 T309409_1 - 3.4e-37 125.1 62.0 3.9e-08 33.3 0.9 10.0 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2 PF00096.24 T309409_1 - 2.1e-31 106.5 66.2 3.5e-06 27.0 0.4 10.1 9 0 0 9 9 9 8 Zinc finger, C2H2 type BTB PF00651.29 T309409_1 - 4.7e-26 91.0 0.5 7.5e-26 90.4 0.5 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 T309409_1 - 5.8e-18 63.9 65.4 0.0038 17.8 0.4 10.3 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T309409_1 - 1e-06 28.8 32.7 2 8.7 0.0 8.5 8 0 0 8 8 8 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T309409_1 - 0.0039 17.4 0.4 0.0039 17.4 0.4 8.2 8 0 0 8 8 8 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 T309409_1 - 0.0063 16.3 0.1 0.0063 16.3 0.1 8.7 8 0 0 8 8 8 2 C2H2-type zinc finger DUF2180 PF09947.7 T309409_1 - 3.1 7.7 7.7 13 5.7 0.1 3.5 2 2 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2180) CH PF00307.29 T309409_2 - 6.3e-18 64.8 0.0 1.1e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF1725 PF08333.9 T309409_2 - 7.4e-07 28.5 1.1 1.5e-06 27.6 1.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) CAMSAP_CH PF11971.6 T309409_2 - 0.031 14.0 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 CAMSAP CH domain DUF3585 PF12130.6 T309409_3 - 7.6e-32 110.2 21.6 1.2e-31 109.6 21.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) FAD_binding_3 PF01494.17 T309409_3 - 2.1e-05 23.8 0.0 3e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain LIM PF00412.20 T309409_3 - 5.6e-05 23.1 7.2 5.6e-05 23.1 7.2 2.5 3 0 0 3 3 2 1 LIM domain Pyr_redox_2 PF07992.12 T309409_3 - 0.00031 20.0 0.0 0.00051 19.3 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 T309409_3 - 0.0037 16.3 0.1 0.0037 16.3 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.4 T309409_3 - 0.007 15.5 0.0 0.01 14.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 T309409_3 - 0.0077 15.8 0.2 0.095 12.2 0.3 2.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.12 T309409_3 - 0.019 13.6 0.0 0.027 13.1 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_8 PF13450.4 T309409_3 - 0.034 14.2 0.1 0.078 13.1 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 T309409_3 - 0.04 14.4 0.1 0.08 13.4 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.10 T309409_3 - 0.051 12.5 0.0 0.078 11.9 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_7 PF13241.4 T309409_3 - 0.12 12.7 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding Pkinase PF00069.23 T146748_1 - 2.2e-73 246.7 0.0 3.5e-73 246.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T146748_1 - 2.2e-33 115.5 0.0 3.3e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 T146748_1 - 0.0015 17.7 0.0 0.0068 15.6 0.0 1.8 1 1 0 1 1 1 1 Kinase-like 3Beta_HSD PF01073.17 T130561_1 - 2.6e-93 312.0 0.0 3.6e-93 311.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 T130561_1 - 5.5e-23 81.5 0.0 9.5e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family N-SET PF11764.6 T130561_1 - 5e-22 78.7 3.1 5e-22 78.7 3.1 5.3 4 2 0 4 4 2 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.26 T130561_1 - 6.9e-15 55.7 0.2 6.9e-15 55.7 0.2 3.2 2 1 0 2 2 1 1 SET domain GDP_Man_Dehyd PF16363.3 T130561_1 - 1.4e-14 54.1 0.0 2.4e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.10 T130561_1 - 8.1e-13 48.0 0.1 9.1e-12 44.5 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.4 T130561_1 - 5.8e-10 39.3 0.0 1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.8 T130561_1 - 4.6e-08 33.0 0.0 9.9e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.13 T130561_1 - 1.9e-07 30.4 0.0 3e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.15 T130561_1 - 6.9e-06 25.2 0.0 1.2e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain RRM_1 PF00076.20 T130561_1 - 9.4e-06 25.2 0.0 1.6e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NmrA PF05368.11 T130561_1 - 0.00059 19.3 0.0 0.00091 18.7 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.23 T130561_1 - 0.00086 18.7 0.0 0.0014 17.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.16 T130561_1 - 0.022 14.9 0.1 0.11 12.7 0.1 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TFIIA PF03153.11 T130561_1 - 2.7 7.8 34.9 0.022 14.6 15.5 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Orai-1 PF07856.10 T130561_3 - 1.1e-50 171.6 2.0 1.7e-50 171.0 2.0 1.2 1 0 0 1 1 1 1 Mediator of CRAC channel activity zf-CHCC PF10276.7 T323281_1 - 0.052 13.5 0.7 0.16 12.0 0.7 1.8 1 0 0 1 1 1 0 Zinc-finger domain Thyroglobulin_1 PF00086.16 T323281_3 - 3.8e-18 64.8 3.1 8.9e-18 63.6 3.1 1.7 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 T323281_3 - 9.6e-09 35.6 20.1 9.6e-09 35.6 20.1 2.6 2 1 0 2 2 2 1 Insulin-like growth factor binding protein FLYWCH_N PF15423.4 T125762_2 - 8.4e-46 154.4 4.2 1.4e-45 153.7 4.2 1.3 1 0 0 1 1 1 1 FLYWCH-type zinc finger-containing protein Peptidase_C2 PF00648.19 T124182_3 - 2.3e-81 272.9 0.0 3.4e-81 272.4 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease RBD-FIP PF09457.8 T124182_3 - 4.4e-20 71.2 1.3 4.4e-20 71.2 1.3 2.4 3 0 0 3 3 3 1 FIP domain zf-RanBP PF00641.16 T124182_3 - 3.6e-08 32.5 20.7 4.3e-06 25.8 0.8 3.3 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others EF-hand_7 PF13499.4 T124182_3 - 2e-05 24.9 0.0 5.5e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 T124182_3 - 0.00031 20.3 1.1 0.0047 16.6 0.3 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.30 T124182_3 - 0.0049 16.2 0.7 0.14 11.7 0.3 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 T124182_3 - 0.065 12.9 1.1 3.5 7.3 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.4 T124182_3 - 0.2 11.1 2.3 0.31 10.5 1.4 1.8 2 0 0 2 2 2 0 EF hand WD40_alt PF14077.4 T124182_3 - 0.43 10.4 4.8 0.11 12.2 0.4 2.1 2 0 0 2 2 2 0 Alternative WD40 repeat motif bZIP_1 PF00170.19 T124182_3 - 1.4 9.0 23.7 0.72 9.9 6.0 3.5 3 0 0 3 3 3 0 bZIP transcription factor zf-C2H2 PF00096.24 T365131_3 - 7.4e-05 22.9 28.3 0.62 10.5 2.9 5.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type Dimer_Tnp_hAT PF05699.12 T365131_3 - 0.0054 16.4 0.1 0.011 15.4 0.1 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-H2C2_2 PF13465.4 T365131_3 - 0.17 12.3 15.8 6.6 7.3 0.1 5.5 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2_4 PF13894.4 T365131_3 - 0.41 11.5 43.5 0.12 13.1 2.3 6.7 6 0 0 6 6 6 0 C2H2-type zinc finger Ank_2 PF12796.5 T211189_2 - 3.4e-18 65.9 0.1 2.3e-07 31.2 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 T211189_2 - 3.7e-15 55.5 12.8 0.02 15.2 0.0 7.7 8 0 0 8 8 8 5 Ankyrin repeat Ank_4 PF13637.4 T211189_2 - 7.4e-13 48.6 3.3 0.0011 19.4 0.0 6.0 4 1 2 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 T211189_2 - 2.9e-11 42.4 3.1 0.72 10.5 0.0 7.4 7 0 0 7 7 7 2 Ankyrin repeat MORN PF02493.18 T211189_2 - 9.1e-07 28.3 17.0 9.2e-05 22.0 2.2 4.3 4 0 0 4 4 4 2 MORN repeat zf-MYND PF01753.16 T211189_2 - 1.4e-05 24.9 8.5 1.4e-05 24.9 8.5 3.2 3 0 0 3 3 3 1 MYND finger Ank_5 PF13857.4 T211189_2 - 0.0035 17.5 3.9 22 5.4 0.1 4.8 4 1 1 5 5 5 1 Ankyrin repeats (many copies) 7tm_4 PF13853.4 T059287_1 - 1.4e-42 146.2 11.0 2.4e-42 145.5 11.0 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T059287_1 - 2.7e-21 75.9 0.2 4.8e-21 75.1 0.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 T059287_2 - 5.2e-42 144.4 17.8 7.9e-42 143.8 17.8 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T059287_2 - 8.3e-19 67.7 13.5 2.1e-18 66.4 13.5 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sushi PF00084.18 T024822_2 - 1.8e-75 249.3 87.0 2.4e-10 40.8 4.6 9.7 9 0 0 9 9 9 9 Sushi repeat (SCR repeat) Lectin_C PF00059.19 T024822_2 - 8.5e-23 81.0 8.3 2.2e-22 79.7 8.3 1.8 1 0 0 1 1 1 1 Lectin C-type domain EGF PF00008.25 T024822_2 - 0.0006 19.9 8.4 0.0006 19.9 8.4 4.8 3 0 0 3 3 3 1 EGF-like domain EGF_2 PF07974.11 T024822_2 - 0.0019 18.4 9.1 0.0019 18.4 9.1 3.6 2 0 0 2 2 2 1 EGF-like domain Lipocalin PF00061.21 T369674_1 - 2e-06 27.9 0.0 1.7e-05 24.9 0.0 2.0 1 1 1 2 2 2 1 Lipocalin / cytosolic fatty-acid binding protein family Methyltransf_11 PF08241.10 T213991_1 - 3.1e-12 46.8 0.0 5e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 T213991_1 - 1.2e-08 35.0 0.1 2.4e-08 33.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 T213991_1 - 4.9e-07 30.2 0.0 8.6e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 T213991_1 - 1e-05 26.0 0.0 1.8e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 T213991_1 - 0.00023 20.5 0.0 0.00041 19.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.4 T213991_1 - 0.00025 20.7 0.0 0.00043 20.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Glycos_transf_2 PF00535.24 T219858_2 - 2.6e-36 124.9 0.0 3.3e-36 124.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.4 T219858_2 - 1.8e-11 44.2 0.0 4e-11 43.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.7 T219858_2 - 0.00014 21.4 0.0 0.00019 20.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.4 T219858_2 - 0.12 12.8 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 LRR_8 PF13855.4 T292926_1 - 5.7e-13 48.3 2.8 9e-13 47.6 1.7 1.9 1 1 0 1 1 1 1 Leucine rich repeat LRRNT PF01462.16 T292926_1 - 1.8e-08 33.7 2.8 1.8e-08 33.7 2.8 2.7 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.5 T292926_1 - 4.5e-05 23.6 5.8 0.0059 16.8 0.1 2.8 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 T292926_1 - 0.001 18.9 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 T292926_1 - 0.077 12.4 1.5 0.12 11.7 1.5 1.2 1 0 0 1 1 1 0 Leucine-rich repeat Abi PF02517.14 T292926_2 - 0.29 11.4 4.0 0.35 11.1 1.4 2.3 2 0 0 2 2 2 0 CAAX protease self-immunity MARVEL PF01284.21 T155407_1 - 1.6e-09 37.8 0.9 1.6e-09 37.8 0.9 2.5 3 0 0 3 3 3 1 Membrane-associating domain PhyH PF05721.11 T367278_1 - 1.7e-21 77.4 0.0 2.4e-21 76.8 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) PhyH PF05721.11 T367278_3 - 2.5e-33 116.0 0.0 3.6e-33 115.5 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DEAD PF00270.27 T274180_2 - 3.6e-15 56.0 0.0 7.6e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.13 T274180_2 - 2.5e-10 40.5 0.8 8.7e-09 35.5 0.0 3.3 3 1 1 4 4 4 1 Type III restriction enzyme, res subunit Helicase_C PF00271.29 T274180_2 - 2.7e-06 27.6 0.0 1.2e-05 25.5 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PhoH PF02562.14 T274180_2 - 0.032 13.6 0.0 0.062 12.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein zf-H2C2_2 PF13465.4 T245523_1 - 8.2e-18 63.8 16.8 6e-08 32.7 0.4 4.2 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.24 T245523_1 - 7.3e-08 32.3 24.2 9.2e-05 22.6 0.9 4.2 4 0 0 4 4 4 2 Zinc finger, C2H2 type Zn-ribbon_8 PF09723.8 T245523_1 - 0.0097 15.9 2.3 0.0097 15.9 2.3 2.6 2 0 0 2 2 2 1 Zinc ribbon domain zf-C2H2_6 PF13912.4 T245523_1 - 0.038 13.8 16.2 0.19 11.6 0.6 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_4 PF13894.4 T245523_1 - 0.044 14.5 0.8 0.044 14.5 0.8 5.1 4 0 0 4 4 4 0 C2H2-type zinc finger C1_4 PF07975.10 T245523_1 - 0.31 11.2 6.8 1.9 8.7 0.2 2.5 2 0 0 2 2 2 0 TFIIH C1-like domain zf-AN1 PF01428.14 T245523_1 - 1.5 8.9 12.6 0.66 10.1 0.7 3.7 2 1 0 3 3 3 0 AN1-like Zinc finger XPA_N PF01286.16 T245523_1 - 3.2 7.7 10.3 9.4 6.2 0.5 3.4 3 0 0 3 3 3 0 XPA protein N-terminal DZR PF12773.5 T245523_1 - 4.7 7.2 11.8 83 3.2 9.9 2.5 1 1 0 1 1 1 0 Double zinc ribbon zf-H2C2_2 PF13465.4 T245523_2 - 3.8e-95 308.3 164.0 2.3e-08 34.0 2.5 20.1 21 0 0 21 21 21 15 Zinc-finger double domain zf-C2H2 PF00096.24 T245523_2 - 1.9e-62 204.3 178.3 9.8e-07 28.8 0.6 20.5 20 0 0 20 20 20 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T245523_2 - 3.4e-25 86.4 168.9 0.01 16.5 0.6 19.2 20 0 0 20 20 20 15 C2H2-type zinc finger KRAB PF01352.25 T245523_2 - 8.1e-22 76.5 1.4 1.4e-21 75.7 1.4 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T245523_2 - 2.2e-12 46.4 115.6 0.063 13.1 0.1 18.1 19 0 0 19 19 19 11 C2H2-type zinc finger XPA_N PF01286.16 T245523_2 - 1.9e-05 24.4 72.9 5.2 7.1 0.1 15.4 15 0 0 15 15 15 7 XPA protein N-terminal Zn-ribbon_8 PF09723.8 T245523_2 - 3.6e-05 23.7 102.3 0.074 13.1 4.0 11.4 8 3 4 12 12 12 8 Zinc ribbon domain DUF3268 PF11672.6 T245523_2 - 0.0079 16.4 64.3 0.27 11.5 0.4 8.5 4 1 6 11 11 11 9 zinc-finger-containing domain zf-C2H2_jaz PF12171.6 T245523_2 - 0.015 15.4 92.8 0.3 11.3 0.3 15.6 16 0 0 16 16 16 0 Zinc-finger double-stranded RNA-binding PHY PF00360.18 T228158_1 - 0.061 12.5 0.1 0.094 11.9 0.1 1.2 1 0 0 1 1 1 0 Phytochrome region Na_Ca_ex PF01699.22 T109136_3 - 3.8e-27 95.0 20.2 6.4e-27 94.3 20.2 1.4 1 0 0 1 1 1 1 Sodium/calcium exchanger protein Lamp PF01299.15 T141023_2 - 2e-81 273.9 20.2 4.6e-81 272.7 19.8 1.7 1 1 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) DEAD PF00270.27 T141023_2 - 5.5e-43 146.6 0.3 9.2e-43 145.9 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 T141023_2 - 8.5e-30 103.3 0.2 2.6e-29 101.7 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain TNF PF00229.16 T141023_2 - 2.2e-27 95.4 0.0 1.7e-14 53.7 0.0 2.3 2 0 0 2 2 2 2 TNF(Tumour Necrosis Factor) family ResIII PF04851.13 T141023_2 - 1.2e-05 25.2 0.0 2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peptidase_C48 PF02902.17 T141023_2 - 0.00042 20.1 0.1 0.00064 19.5 0.1 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain ATP-synt_S1 PF05827.10 T141023_2 - 0.011 15.4 0.1 0.019 14.7 0.1 1.3 1 0 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) C1q PF00386.19 T141023_2 - 0.12 12.4 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 C1q domain Nop53 PF07767.9 T141023_2 - 1.5 8.1 8.7 0.17 11.2 2.4 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Peptidase_C48 PF02902.17 T141023_3 - 7.2e-36 123.9 4.2 9.7e-36 123.5 1.6 2.1 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain zf-H2C2_2 PF13465.4 T168757_1 - 2.2e-67 220.5 106.2 7.1e-08 32.4 2.5 13.9 13 0 0 13 13 13 12 Zinc-finger double domain KRAB PF01352.25 T168757_1 - 1e-21 76.2 0.1 1.8e-21 75.4 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2 PF00096.24 T168757_1 - 4.9e-21 73.8 107.8 4.5e-05 23.5 0.5 13.6 12 0 0 12 12 12 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T168757_1 - 5.4e-15 54.7 111.0 0.027 15.1 1.7 14.2 13 0 0 13 13 13 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T168757_1 - 2e-06 27.5 91.1 0.14 12.0 0.3 12.8 12 0 0 12 12 12 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T168757_1 - 0.28 11.2 70.9 0.26 11.3 3.0 9.0 3 1 9 12 12 12 0 Zinc ribbon domain zf-H2C2_2 PF13465.4 T168757_2 - 3.4e-14 52.4 25.7 1.1e-06 28.6 1.1 6.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-H2C2_2 PF13465.4 T168757_3 - 1.1e-12 47.6 31.3 7.4e-05 22.9 3.3 5.7 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 T168757_3 - 4.6e-06 26.7 28.7 0.31 11.4 2.7 5.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T168757_3 - 0.00011 22.6 28.2 0.32 11.8 0.3 5.9 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T168757_3 - 0.00028 20.6 21.5 0.032 14.1 0.4 5.1 4 0 0 4 4 4 2 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T168757_3 - 1.8 9.2 11.0 5.2 7.8 2.7 2.7 2 0 0 2 2 2 0 zinc-ribbon family Zn-ribbon_8 PF09723.8 T168757_3 - 2.6 8.1 21.0 2.6 8.1 4.4 4.1 2 2 2 4 4 4 0 Zinc ribbon domain DUF3268 PF11672.6 T168757_3 - 7.1 6.9 10.0 0.22 11.7 1.1 2.3 2 0 0 2 2 2 0 zinc-finger-containing domain Lectin_C PF00059.19 T192534_3 - 4.3e-22 78.8 0.3 7.2e-22 78.0 0.3 1.4 1 0 0 1 1 1 1 Lectin C-type domain Ribosomal_L30_N PF08079.10 T303800_1 - 3.8e-18 65.4 6.7 3.8e-18 65.4 6.7 1.8 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.18 T303800_1 - 1.6e-16 59.9 1.1 4.1e-16 58.5 1.1 1.8 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e TGF_beta_GS PF08515.10 T303800_1 - 0.031 13.6 0.3 0.062 12.7 0.3 1.5 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif GAS PF13851.4 T332874_1 - 0.0026 17.0 2.3 0.0026 17.0 2.3 8.1 3 2 3 8 8 8 1 Growth-arrest specific micro-tubule binding zf-C4 PF00105.16 T084348_1 - 1.4e-31 108.6 15.4 3.8e-31 107.2 15.4 1.8 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 T084348_1 - 6.9e-15 55.0 0.7 1.1e-14 54.4 0.1 1.6 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor DUF2318 PF10080.7 T084348_1 - 0.011 15.8 0.5 0.031 14.3 0.5 1.8 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Sec63 PF02889.14 T014991_1 - 1.7e-09 37.1 0.0 2.6e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain Sec63 PF02889.14 T014991_2 - 4.3e-07 29.2 0.1 7.2e-07 28.5 0.1 1.4 1 0 0 1 1 1 1 Sec63 Brl domain Hfq PF17209.1 T014991_2 - 0.085 12.4 0.2 0.2 11.2 0.2 1.5 1 0 0 1 1 1 0 Hfq protein Sec63 PF02889.14 T014991_3 - 0.0028 16.7 0.1 0.0055 15.8 0.1 1.4 1 0 0 1 1 1 1 Sec63 Brl domain VWD PF00094.23 T076899_2 - 7.7e-62 208.1 15.1 6.2e-28 97.9 2.1 3.4 3 0 0 3 3 3 3 von Willebrand factor type D domain C8 PF08742.9 T076899_2 - 2.4e-34 117.4 33.7 8.1e-15 54.9 5.3 3.9 3 0 0 3 3 3 3 C8 domain TIL PF01826.15 T076899_2 - 3.2e-09 36.7 45.6 4.7e-08 33.0 10.1 9.1 10 0 0 10 10 10 4 Trypsin Inhibitor like cysteine rich domain Cys_knot PF00007.20 T076899_3 - 8.1e-06 25.9 16.3 1.6e-05 25.0 16.3 1.3 1 0 0 1 1 1 1 Cystine-knot domain BTB PF00651.29 T260223_1 - 2.8e-25 88.6 2.1 4.7e-25 87.8 2.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 T260223_1 - 3.6e-06 27.0 1.0 1.4e-05 25.1 1.0 2.1 1 0 0 1 1 1 1 Zinc finger, C2H2 type PyrI_C PF02748.13 T260223_1 - 0.00015 21.5 0.6 0.00037 20.2 0.6 1.7 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.6 T260223_1 - 0.0015 18.7 0.3 0.0044 17.2 0.3 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 T260223_1 - 0.0019 18.4 0.4 0.0074 16.5 0.4 2.1 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 T260223_1 - 0.022 15.4 1.1 0.12 13.2 1.1 2.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 T260223_2 - 0.00011 22.3 0.5 0.00025 21.2 0.5 1.6 1 0 0 1 1 1 1 Zinc-finger double domain zf-H2C2_2 PF13465.4 T260223_3 - 5.1e-09 36.0 2.7 5.1e-09 36.0 2.7 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.24 T260223_3 - 1.6e-05 24.9 10.4 0.0008 19.6 4.1 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T260223_3 - 7.4e-05 23.1 5.7 0.021 15.5 3.2 3.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.5 T260223_3 - 0.0052 17.0 1.7 0.02 15.1 1.7 2.1 1 0 0 1 1 1 1 Zinc-finger of C2H2 type GAGA PF09237.9 T260223_3 - 0.081 12.6 1.3 0.26 11.0 1.3 1.8 1 1 0 1 1 1 0 GAGA factor zf-C2H2_6 PF13912.4 T260223_3 - 0.15 11.9 3.4 0.44 10.4 3.4 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger SET PF00856.26 T225658_3 - 1.7e-12 47.9 0.0 3e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.9 T225658_3 - 3.7e-10 40.5 0.1 5.9e-10 39.8 0.1 1.3 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Glycos_transf_3 PF00591.19 T236453_1 - 3.2e-53 180.8 0.9 4.2e-53 180.4 0.9 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.15 T236453_1 - 9e-17 60.5 0.1 1.6e-16 59.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain SCO1-SenC PF02630.12 T236453_3 - 3.4e-44 150.6 0.0 5e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.4 T236453_3 - 0.0022 18.2 0.0 0.0034 17.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like SHIPPO-rpt PF07004.10 T236453_3 - 0.011 16.5 0.1 0.011 16.5 0.1 6.6 7 0 0 7 7 7 0 Sperm-tail PG-rich repeat AhpC-TSA PF00578.19 T236453_3 - 0.097 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family PIH1 PF08190.10 T067266_2 - 5.9e-16 59.1 3.7 2.1e-15 57.2 3.7 1.8 1 1 0 1 1 1 1 pre-RNA processing PIH1/Nop17 DnaJ PF00226.29 T067266_2 - 0.11 12.5 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 DnaJ domain Dynein_heavy PF03028.13 T243351_1 - 4.1e-233 775.5 0.0 1.1e-232 774.1 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.5 T243351_1 - 1.4e-91 305.4 0.4 5.8e-90 300.1 0.7 2.5 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 T243351_1 - 1.2e-81 273.7 0.1 2.3e-81 272.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.5 T243351_1 - 3.2e-52 177.5 3.7 4.8e-52 177.0 3.7 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.5 T243351_1 - 5.9e-51 173.2 0.0 1.4e-50 172.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_6 PF12774.5 T243351_1 - 1.9e-20 73.5 0.0 5.5e-20 72.0 0.0 1.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_5 PF07728.12 T243351_1 - 1.6e-13 50.7 0.0 6.4e-06 26.1 0.0 3.7 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) DUF4147 PF13660.4 T243351_1 - 1.6e-08 34.2 0.0 2.9e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) AAA_16 PF13191.4 T243351_1 - 1.2e-06 28.8 0.0 0.4 10.9 0.0 4.1 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.4 T243351_1 - 5e-06 26.7 0.0 0.56 10.4 0.0 3.8 3 0 0 3 3 3 2 AAA domain AAA PF00004.27 T243351_1 - 6.3e-05 23.3 0.3 2.9 8.2 0.0 4.3 5 0 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.18 T243351_1 - 0.00052 19.0 4.2 0.47 9.3 0.0 3.3 4 0 0 4 4 4 2 Type II/IV secretion system protein AAA_18 PF13238.4 T243351_1 - 0.001 19.5 0.2 9.1 6.7 0.0 4.3 4 0 0 4 4 4 0 AAA domain Mg_chelatase PF01078.19 T243351_1 - 0.0015 17.8 0.0 0.26 10.5 0.0 3.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI ResIII PF04851.13 T243351_1 - 0.0017 18.2 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ABC_tran PF00005.25 T243351_1 - 0.0017 18.7 0.4 0.23 11.9 0.0 3.2 3 0 0 3 3 3 1 ABC transporter AAA_33 PF13671.4 T243351_1 - 0.0087 16.1 0.1 1.1 9.3 0.1 2.7 2 0 0 2 2 2 1 AAA domain DEAD PF00270.27 T243351_1 - 0.025 14.2 0.0 6.2 6.4 0.0 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase RNA_helicase PF00910.20 T243351_1 - 0.036 14.3 0.1 3.2 8.0 0.0 3.1 3 0 0 3 3 2 0 RNA helicase AAA_29 PF13555.4 T243351_1 - 0.037 13.6 3.3 0.22 11.1 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain Rad17 PF03215.13 T243351_1 - 0.061 12.1 0.3 5 5.8 0.0 2.3 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein AAA_30 PF13604.4 T243351_1 - 0.071 12.7 0.4 4.9 6.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.4 T243351_1 - 0.13 12.5 0.1 7.3 6.8 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_25 PF13481.4 T243351_1 - 0.14 11.6 0.5 3.8 6.9 0.1 2.5 2 0 0 2 2 2 0 AAA domain PhoH PF02562.14 T243351_1 - 0.18 11.1 0.1 1.4 8.2 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein Alanine_zipper PF11839.6 T243351_1 - 2 8.6 8.5 6.8 6.9 8.5 1.9 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein DUF3584 PF12128.6 T243351_1 - 2.9 5.2 12.0 2.3 5.5 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) ISG65-75 PF11727.6 T243351_1 - 4 6.4 9.7 8.7 5.4 9.7 1.5 1 0 0 1 1 1 0 Invariant surface glycoprotein Fez1 PF06818.13 T243351_1 - 6 7.1 12.9 0.84 9.9 0.6 2.4 2 0 0 2 2 2 0 Fez1 Dynein_heavy PF03028.13 T243351_2 - 8.5e-37 126.6 0.0 1.1e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.11 T243351_3 - 3e-144 480.9 14.5 3e-144 480.9 14.5 1.9 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 T243351_3 - 1.5e-69 234.2 0.0 2.3e-69 233.5 0.0 1.3 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 Seryl_tRNA_N PF02403.20 T243351_3 - 0.018 15.1 0.6 0.049 13.7 0.0 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain AAA_18 PF13238.4 T243351_3 - 0.023 15.1 0.0 0.13 12.6 0.0 2.3 1 0 0 1 1 1 0 AAA domain MAM PF00629.21 T187153_2 - 2.1e-30 105.6 0.1 3.1e-21 75.8 0.2 2.3 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu Gly_rich PF12810.5 T187153_2 - 7.7e-12 45.5 13.6 1.8e-11 44.3 13.6 1.5 1 0 0 1 1 1 1 Glycine rich protein Ldl_recept_a PF00057.16 T187153_2 - 0.026 14.6 1.8 0.081 13.0 1.8 1.9 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A Pkinase_Tyr PF07714.15 T187153_3 - 2.2e-88 295.8 0.0 2.8e-88 295.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 T187153_3 - 4.3e-32 111.4 0.0 6e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain EF1_GNE PF00736.17 T353543_2 - 4.1e-35 119.7 0.4 6.5e-35 119.0 0.4 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 T353543_2 - 1.2e-11 44.7 7.6 1.2e-11 44.7 7.6 2.0 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region NAPRTase PF04095.14 T353543_2 - 0.01 15.4 0.0 0.032 13.7 0.0 1.7 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) family Striatin PF08232.10 T353543_2 - 0.054 14.0 1.7 0.092 13.2 1.7 1.3 1 0 0 1 1 1 0 Striatin family HEAT PF02985.20 T353543_2 - 0.14 12.3 1.4 31 5.0 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat JIP_LZII PF16471.3 T353543_2 - 0.23 11.5 0.5 0.41 10.7 0.5 1.3 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II CENP-B_N PF04218.11 T202130_1 - 6.4e-05 22.4 0.0 0.00012 21.4 0.0 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DDE_1 PF03184.17 T202130_2 - 0.019 14.4 0.1 0.029 13.8 0.1 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease Cobl PF09469.8 T202130_3 - 7.5e-44 147.8 1.9 1e-43 147.4 0.6 1.9 2 0 0 2 2 2 1 Cordon-bleu ubiquitin-like domain DDE_1 PF03184.17 T202130_3 - 3.5e-06 26.6 0.0 2.7e-05 23.7 0.0 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease RBD PF02196.13 T202130_3 - 0.00059 19.8 0.2 0.13 12.3 0.0 2.5 2 0 0 2 2 2 2 Raf-like Ras-binding domain CCDC144C PF14915.4 T159398_1 - 6.1e-95 317.7 45.3 6.1e-95 317.7 45.3 2.2 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region DUF2863 PF11062.6 T159398_2 - 2.1 6.5 4.9 43 2.2 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2863) Neur_chan_memb PF02932.14 T140088_2 - 5.3e-26 92.0 0.0 8.2e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 T140088_3 - 8.1e-64 214.9 0.0 1e-63 214.5 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 T140088_3 - 0.098 12.6 0.7 0.14 12.1 0.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SAM_1 PF00536.28 T054202_2 - 1.2e-37 128.0 3.0 7.4e-17 61.4 0.0 3.8 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 T054202_2 - 2e-37 127.0 0.9 1.5e-15 56.9 0.0 3.4 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) Reo_sigmaC PF04582.10 T054202_2 - 0.43 9.8 7.4 1.5 8.1 3.7 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein CALCOCO1 PF07888.9 T054202_2 - 1.5 7.2 26.9 2.5 6.4 26.9 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like TRPM_tetra PF16519.3 T360136_3 - 1.3e-23 82.7 5.4 2.5e-23 81.8 5.4 1.5 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.29 T360136_3 - 1e-17 64.1 17.4 1.6e-17 63.4 17.4 1.2 1 0 0 1 1 1 1 Ion transport protein DUF3552 PF12072.6 T360136_3 - 0.079 12.2 4.2 0.16 11.3 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Transposase_22 PF02994.12 T327204_1 - 9.2e-06 24.6 0.1 1.4e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 L1 transposable element GSAP-16 PF14959.4 T327204_2 - 2.5e-38 130.1 0.2 4.8e-38 129.2 0.2 1.5 1 0 0 1 1 1 1 gamma-Secretase-activating protein C-term Transposase_22 PF02994.12 T327204_2 - 8.6e-12 44.5 4.5 3.9e-08 32.4 0.1 2.2 2 0 0 2 2 2 2 L1 transposable element DUF4577 PF15145.4 T331287_2 - 1.9e-43 147.4 1.4 3e-43 146.7 1.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) DUF948 PF06103.9 T331287_2 - 0.053 13.7 0.3 0.08 13.1 0.3 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) CCDC85 PF10226.7 T331287_2 - 0.17 11.4 0.5 0.24 10.9 0.5 1.1 1 0 0 1 1 1 0 CCDC85 family zf-CCCH PF00642.22 T173960_1 - 0.015 15.1 17.8 0.032 14.0 0.5 2.8 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.20 T173960_2 - 0.00057 19.5 0.0 0.00091 18.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRY PF13765.4 T142260_3 - 2.1e-16 59.1 0.2 2.1e-16 59.1 0.2 1.9 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 T142260_3 - 7.4e-13 48.6 0.2 1.6e-12 47.5 0.2 1.6 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 T142260_3 - 8.4e-07 28.9 14.1 8.4e-07 28.9 14.1 2.9 2 1 0 2 2 2 1 B-box zinc finger IL6 PF00489.15 T142260_3 - 0.031 13.7 0.6 0.056 12.9 0.6 1.3 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family Palm_thioest PF02089.13 T301424_2 - 3.5e-14 52.5 0.0 6e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.18 T301424_2 - 1.9e-05 24.3 0.1 3.4e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.12 T301424_2 - 0.0074 15.7 0.0 0.019 14.3 0.0 1.4 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.11 T301424_2 - 0.067 12.8 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein EMI PF07546.11 T301424_3 - 2.2e-16 60.2 10.2 2.2e-16 60.2 10.2 2.5 2 0 0 2 2 2 1 EMI domain EGF PF00008.25 T301424_3 - 0.00052 20.1 7.0 0.00052 20.1 7.0 3.4 2 0 0 2 2 2 1 EGF-like domain VHS PF00790.17 T150870_1 - 1.6e-30 105.7 0.0 2.7e-30 104.9 0.0 1.4 1 0 0 1 1 1 1 VHS domain GAT PF03127.12 T150870_1 - 6.6e-18 64.7 2.6 1.6e-17 63.5 2.6 1.7 1 0 0 1 1 1 1 GAT domain Ig_2 PF13895.4 T176045_1 - 3.6e-29 100.8 6.0 2.1e-17 63.1 0.6 3.5 3 1 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 T176045_1 - 8.6e-28 96.7 7.4 3.9e-12 46.5 0.4 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 T176045_1 - 3.8e-24 84.8 2.2 1.4e-12 47.6 0.0 4.2 3 2 1 4 4 4 3 Immunoglobulin V-set domain I-set PF07679.14 T176045_1 - 2.5e-21 75.4 0.1 3.2e-07 30.2 0.0 4.1 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 T176045_1 - 2.8e-20 72.2 2.6 1.4e-07 31.5 0.1 3.8 3 1 0 3 3 3 3 Immunoglobulin domain Receptor_2B4 PF11465.6 T176045_1 - 0.004 17.2 0.0 5.1 7.2 0.0 2.7 3 0 0 3 3 3 2 Natural killer cell receptor 2B4 Ig_5 PF16681.3 T176045_1 - 0.011 16.1 0.0 0.51 10.7 0.0 2.4 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Adeno_E3_CR1 PF02440.13 T176045_1 - 0.012 15.2 0.8 3.6 7.3 0.1 3.1 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 Izumo-Ig PF16706.3 T176045_1 - 0.017 15.0 0.0 0.48 10.4 0.0 2.5 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain BiPBP_C PF06832.10 T176045_1 - 0.055 13.4 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family SH3_2 PF07653.15 T151369_1 - 2.7e-35 119.7 0.0 4.6e-11 42.1 0.0 3.7 3 0 0 3 3 3 3 Variant SH3 domain SH3_9 PF14604.4 T151369_1 - 3.9e-30 103.3 1.9 2.3e-10 40.0 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 T151369_1 - 2.2e-13 49.4 0.0 0.00084 18.8 0.0 3.6 3 0 0 3 3 3 3 SH3 domain fn3 PF00041.19 T151369_1 - 0.0035 17.5 0.2 6.9 7.0 0.1 3.5 2 1 0 2 2 2 2 Fibronectin type III domain FSIP2 PF15783.3 T204308_2 - 0 1923.8 201.5 0 1550.5 61.3 15.1 9 2 6 15 15 15 11 Fibrous sheath-interacting protein 2 DUF3931 PF13082.4 T204308_2 - 0.076 13.1 5.4 0.49 10.5 0.4 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3931) 2OG-FeII_Oxy_2 PF13532.4 T066906_1 - 3.4e-19 69.7 0.0 5.8e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_11 PF08241.10 T066906_1 - 4.8e-15 55.8 0.1 7.7e-15 55.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 T066906_1 - 2.2e-13 50.6 0.1 3.5e-13 50.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 T066906_1 - 1.5e-06 28.0 0.0 2.7e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T066906_1 - 5.4e-06 26.1 0.0 9.2e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 T066906_1 - 4.8e-05 23.9 0.0 9.6e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.13 T066906_1 - 0.00015 21.6 0.0 0.00024 20.9 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Ubie_methyltran PF01209.16 T066906_1 - 0.057 12.6 0.0 0.094 11.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF1891 PF09004.8 T066906_3 - 8.8e-15 53.9 1.5 1.8e-14 52.9 1.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) RRM_1 PF00076.20 T066906_3 - 0.00034 20.2 0.0 0.00063 19.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Disintegrin PF00200.21 T342584_2 - 2e-19 70.0 27.4 2e-19 70.0 27.4 4.1 3 1 0 3 3 3 1 Disintegrin ADAM_CR PF08516.10 T342584_2 - 1.8e-11 44.4 15.6 1.8e-11 44.4 15.6 4.0 3 1 1 4 4 4 1 ADAM cysteine-rich Reprolysin PF01421.17 T342584_2 - 9.9e-06 25.5 1.3 9.9e-06 25.5 1.3 2.5 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease Lipocalin PF00061.21 T369641_3 - 8e-07 29.2 0.0 1.1e-05 25.6 0.0 2.2 1 1 1 2 2 2 1 Lipocalin / cytosolic fatty-acid binding protein family Autophagy_act_C PF03987.13 T369641_3 - 0.028 14.9 0.0 0.064 13.7 0.0 1.6 1 0 0 1 1 1 0 Autophagocytosis associated protein, active-site domain PNP_UDP_1 PF01048.18 T323652_2 - 7.1e-12 44.9 0.0 1.1e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily LIM PF00412.20 T056915_1 - 7e-24 83.7 29.4 1.5e-14 53.9 9.0 2.8 3 0 0 3 3 3 2 LIM domain C1_4 PF07975.10 T056915_1 - 6.7 6.9 14.5 0.38 10.9 5.8 2.6 2 0 0 2 2 2 0 TFIIH C1-like domain TCRP1 PF14944.4 T063686_2 - 2e-109 365.1 51.0 3.2e-109 364.4 51.0 1.3 1 0 0 1 1 1 1 Tongue Cancer Chemotherapy Resistant Protein 1 DUF4723 PF15851.3 T301119_3 - 0.025 14.5 6.8 0.06 13.3 6.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) Sec16_C PF12931.5 T369165_3 - 1.3e-42 146.3 0.1 2.2e-42 145.6 0.1 1.3 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.5 T369165_3 - 5.7e-07 30.0 0.0 1.2e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region LNS2 PF08235.11 T157774_3 - 3.3e-103 343.9 0.0 4.7e-103 343.4 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 T157774_3 - 4.7e-45 151.6 0.0 7.3e-45 151.0 0.0 1.3 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 T157774_3 - 1.2e-34 118.4 0.1 2.6e-34 117.3 0.1 1.5 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.4 T157774_3 - 2e-05 25.2 0.8 7.3e-05 23.4 0.8 2.0 1 0 0 1 1 1 1 Putative WW-binding domain and destruction box DUF2371 PF10177.7 T158110_2 - 3.4e-59 198.9 0.0 7.2e-59 197.8 0.0 1.5 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2371) Neurensin PF14927.4 T158110_2 - 0.13 11.9 0.2 0.48 10.0 0.0 2.0 2 0 0 2 2 2 0 Neurensin SPX PF03105.17 T158110_2 - 5.1 6.8 13.5 3.3 7.4 0.0 2.6 3 0 0 3 3 3 0 SPX domain WD40 PF00400.30 T254095_1 - 1.2e-18 67.0 9.4 0.0012 19.5 0.0 8.6 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T254095_1 - 0.1 12.8 0.3 1.2 9.4 0.1 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Serpin PF00079.18 T254095_2 - 1.6e-110 369.8 7.7 2e-110 369.5 7.7 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) FAM117 PF15388.4 T205982_3 - 6e-125 416.5 12.9 6e-125 416.5 12.9 1.6 2 0 0 2 2 2 1 Protein Family FAM117 START PF01852.17 T287286_3 - 1e-12 47.8 0.0 1.3e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 START domain PDZ PF00595.22 T378552_1 - 1.9e-07 31.2 0.0 3.3e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 T378552_1 - 0.00065 19.8 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain FERM_M PF00373.16 T378552_2 - 1.4e-16 60.9 0.0 1.4e-16 60.9 0.0 2.4 2 0 0 2 2 1 1 FERM central domain RP-C_C PF11800.6 T378552_2 - 0.027 14.4 5.7 0.073 13.0 5.7 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region SKA1 PF07160.10 T378552_2 - 0.046 13.4 9.5 0.1 12.3 9.5 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF4834 PF16118.3 T378552_2 - 0.053 14.4 3.4 0.16 12.8 3.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Peroxin-13_N PF04088.11 T378552_2 - 0.43 10.7 3.9 0.94 9.6 3.9 1.5 1 0 0 1 1 1 0 Peroxin 13, N-terminal region EPL1 PF10513.7 T378552_2 - 0.96 9.7 6.7 2.9 8.1 6.7 1.8 1 0 0 1 1 1 0 Enhancer of polycomb-like Anoctamin PF04547.10 T378552_2 - 1.1 7.9 2.9 1.8 7.1 2.9 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel ZYG-11_interact PF05884.10 T378552_2 - 1.1 8.4 7.4 1.8 7.7 7.4 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 V_ATPase_I PF01496.17 T378552_2 - 1.4 6.6 6.5 2.3 5.9 6.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rpp20 PF12328.6 T378552_2 - 1.7 8.4 8.6 3.5 7.5 8.6 1.4 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P eIF-3_zeta PF05091.10 T378552_2 - 2.3 6.9 7.9 3.8 6.2 7.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CagX PF03524.13 T378552_2 - 3.1 7.3 6.1 5.6 6.5 6.1 1.3 1 0 0 1 1 1 0 Conjugal transfer protein ALMT PF11744.6 T378552_2 - 3.2 6.3 6.6 5.3 5.6 6.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Roughex PF06020.9 T378552_2 - 4 6.3 9.8 7.4 5.4 9.8 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.6 T378552_2 - 5.3 6.4 32.6 0.039 13.4 23.9 1.9 2 0 0 2 2 1 0 Spt20 family Presenilin PF01080.15 T378552_2 - 5.6 5.5 7.5 15 4.1 7.5 1.6 1 0 0 1 1 1 0 Presenilin Coilin_N PF15862.3 T378552_2 - 7.1 6.3 8.8 18 5.0 8.8 1.6 1 0 0 1 1 1 0 Coilin N-terminus TERB2 PF15101.4 T378552_2 - 7.6 6.4 10.3 16 5.3 10.3 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SNF PF00209.16 T071221_2 - 2.5e-297 986.6 58.5 3.6e-241 801.3 38.7 3.1 2 1 1 3 3 3 3 Sodium:neurotransmitter symporter family Syntaxin PF00804.23 T089588_3 - 4.1e-64 215.8 15.5 6.7e-64 215.1 15.5 1.3 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.17 T089588_3 - 4.1e-10 39.4 1.7 4.1e-10 39.4 1.7 2.3 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.4 T089588_3 - 6.7e-09 35.9 5.9 6.7e-09 35.9 5.9 2.1 2 1 0 2 2 2 1 Syntaxin-like protein Syntaxin-6_N PF09177.9 T089588_3 - 0.0084 16.5 1.1 0.0084 16.5 1.1 2.2 1 1 1 2 2 2 1 Syntaxin 6, N-terminal DUF16 PF01519.14 T089588_3 - 0.23 11.8 8.8 0.12 12.7 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 MCPsignal PF00015.19 T089588_3 - 0.4 10.3 6.7 1.7 8.2 0.8 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain ApoLp-III PF07464.9 T089588_3 - 0.49 10.4 6.1 0.25 11.3 1.1 2.1 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) YtxH PF12732.5 T089588_3 - 1.4 9.4 5.5 0.6 10.6 1.0 2.2 2 0 0 2 2 2 0 YtxH-like protein ABC_tran_CTD PF16326.3 T089588_3 - 2.4 8.3 4.7 5.5 7.2 0.2 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain RhoGEF PF00621.18 T134600_1 - 2.3e-28 99.5 0.0 3.8e-28 98.8 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 T134600_1 - 0.0027 18.1 0.0 0.0051 17.2 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 T134600_1 - 0.019 15.1 0.5 0.11 12.7 0.1 2.2 1 1 0 2 2 2 0 Pleckstrin homology domain HET-s_218-289 PF11558.6 T134600_1 - 0.096 12.6 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 Het-s 218-289 F-box-like PF12937.5 T305270_2 - 6.6e-09 35.4 1.8 1.4e-08 34.3 1.8 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 T305270_2 - 8.7e-07 28.5 2.6 2.1e-06 27.3 2.6 1.7 1 0 0 1 1 1 1 F-box domain MIT PF04212.16 T305270_2 - 0.0028 17.6 0.1 0.0048 16.8 0.1 1.3 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Tox-GHH PF15636.4 T379751_2 - 1.1e-28 98.8 1.2 2e-28 98.0 1.2 1.4 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin RHS_repeat PF05593.12 T379751_2 - 2.8e-09 37.1 32.6 0.0018 18.6 0.2 7.9 7 1 0 7 7 7 3 RHS Repeat NHL PF01436.19 T379751_2 - 3.2e-07 29.9 3.1 0.051 13.5 0.0 5.7 5 0 0 5 5 5 2 NHL repeat SBBP PF06739.9 T379751_2 - 0.069 13.0 0.0 0.24 11.3 0.0 2.0 1 0 0 1 1 1 0 Beta-propeller repeat RHS PF03527.12 T379751_2 - 0.13 11.9 1.4 0.24 11.0 0.0 2.2 2 0 0 2 2 2 0 RHS protein RabGAP-TBC PF00566.16 T195361_1 - 4.7e-24 85.1 0.4 9.7e-24 84.1 0.4 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.18 T195361_3 - 1.4e-42 144.0 0.7 1.3e-20 73.1 0.0 2.5 2 0 0 2 2 2 2 GRAM domain RabGAP-TBC PF00566.16 T195361_3 - 3.2e-11 43.2 0.0 5.7e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain JmjC PF02373.20 T375115_1 - 1.6e-10 41.3 0.4 4.8e-10 39.8 0.4 1.8 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.27 T375115_1 - 3.6e-08 33.1 6.6 1.2e-07 31.4 6.6 2.0 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.4 T375115_1 - 2.2e-07 30.8 0.0 4.6e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Cupin-like domain PHD_2 PF13831.4 T375115_1 - 3.1 7.3 11.4 0.051 13.0 2.5 2.8 3 0 0 3 3 3 0 PHD-finger PHD_4 PF16866.3 T375115_1 - 4.2 7.4 6.1 14 5.7 6.1 1.9 1 0 0 1 1 1 0 PHD-finger 7tm_1 PF00001.19 T376173_2 - 1.8e-51 174.8 9.9 4.5e-51 173.5 9.9 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ctr PF04145.13 T376173_2 - 0.00078 20.0 0.2 0.0032 18.0 0.5 1.9 2 0 0 2 2 2 1 Ctr copper transporter family 7TM_GPCR_Srsx PF10320.7 T376173_2 - 0.019 14.2 4.4 0.028 13.7 4.4 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Abi PF02517.14 T061809_2 - 5.6e-08 32.9 1.3 1.2e-07 31.9 1.3 1.5 1 0 0 1 1 1 1 CAAX protease self-immunity DUF4554 PF15091.4 T061809_3 - 2.3e-269 893.8 0.6 3e-269 893.4 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4554) Homeobox PF00046.27 T178017_3 - 3.1e-21 74.8 3.0 5.5e-21 74.0 3.0 1.4 1 0 0 1 1 1 1 Homeobox domain TF_Otx PF03529.11 T178017_3 - 5.8e-15 55.3 17.0 2.1e-14 53.5 17.0 2.1 1 0 0 1 1 1 1 Otx1 transcription factor MRP-L20 PF12824.5 T178017_3 - 0.042 13.9 0.7 0.091 12.8 0.7 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 PPP1R26_N PF15740.3 T368737_3 - 0 1244.2 29.2 0 1243.6 29.2 1.3 1 0 0 1 1 1 1 Protein phosphatase 1 regulatory subunit 26 N-terminus DUF912 PF06024.10 T368737_3 - 0.034 14.3 0.5 0.084 13.1 0.5 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Josephin PF02099.15 T179255_1 - 1e-16 61.3 0.1 8.8e-09 35.5 0.0 2.3 1 1 1 2 2 2 2 Josephin LRR_8 PF13855.4 T179255_2 - 3.4e-41 138.7 24.0 2e-14 52.9 2.5 4.7 2 2 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 T179255_2 - 5.4e-21 74.1 24.4 2.8e-05 24.2 0.3 5.9 2 1 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 T179255_2 - 7e-20 71.1 0.0 1e-12 48.0 0.0 2.2 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) I-set PF07679.14 T179255_2 - 2.9e-15 56.0 0.0 4.3e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T179255_2 - 8.6e-12 45.4 0.2 1.8e-11 44.4 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T179255_2 - 2.3e-09 37.2 0.7 4.5e-09 36.2 0.7 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.4 T179255_2 - 2.4e-09 36.8 4.8 3.8e-06 26.4 0.4 2.2 1 1 0 2 2 2 2 Leucine-rich repeat V-set PF07686.15 T179255_2 - 3.3e-05 23.9 1.5 0.00027 20.9 1.5 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T179255_2 - 5.8e-05 23.2 0.4 0.00013 22.1 0.4 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 T179255_2 - 0.22 12.0 23.8 5.8 7.7 0.0 6.7 6 2 0 6 6 6 0 Leucine Rich Repeat DUF108 PF01958.16 T179255_3 - 1.5e-11 44.3 0.1 3.1e-11 43.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF108 HEAT PF02985.20 T162229_3 - 0.0013 18.7 0.1 16 5.9 0.0 3.8 3 0 0 3 3 3 2 HEAT repeat zf-C6H2 PF15801.3 T162229_3 - 0.0024 18.0 3.9 0.012 15.8 3.9 2.3 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding S_100 PF01023.17 T021338_1 - 1.5e-16 59.6 0.3 2.6e-16 58.9 0.3 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 T021338_1 - 0.0076 16.6 0.3 0.012 15.9 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair S_100 PF01023.17 T021338_2 - 6.4e-66 217.7 13.7 1.6e-17 62.8 0.5 4.4 4 0 0 4 4 4 4 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 T021338_2 - 6.1e-14 52.1 16.0 5.5e-05 23.4 0.4 4.2 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.30 T021338_2 - 1.6e-09 36.5 9.7 0.16 11.5 0.1 4.9 4 0 0 4 4 4 4 EF hand EF-hand_4 PF12763.5 T021338_2 - 0.0019 18.0 1.8 0.44 10.4 0.0 3.4 4 0 0 4 4 4 1 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.4 T021338_2 - 0.02 14.5 7.8 1.3 8.7 0.1 3.3 3 0 0 3 3 3 0 EF-hand domain pair Gcd10p PF04189.11 T213294_1 - 2.1e-71 240.3 0.1 3.9e-71 239.5 0.1 1.5 1 1 0 1 1 1 1 Gcd10p family LCE PF14672.4 T021136_2 - 5.5e-26 90.9 47.5 1.8e-25 89.2 47.5 2.0 1 0 0 1 1 1 1 Late cornified envelope KRAB PF01352.25 T326166_1 - 1.4e-20 72.5 0.3 2.9e-20 71.5 0.3 1.5 1 0 0 1 1 1 1 KRAB box POM121 PF15229.4 T326166_2 - 6e-109 363.1 24.5 6e-109 363.1 24.5 2.0 2 1 1 3 3 3 1 POM121 family NumbF PF06311.10 T175606_2 - 1.2e-28 99.4 0.4 1.2e-28 99.4 0.4 2.4 2 0 0 2 2 2 1 NUMB domain PID PF00640.21 T175606_2 - 2.2e-27 95.7 0.1 2.2e-27 95.7 0.1 1.6 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 T175606_2 - 2.6e-06 27.5 0.0 4.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.4 T175606_2 - 7.8e-05 22.5 0.1 7.8e-05 22.5 0.1 2.0 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) DUF2722 PF10846.6 T175606_2 - 0.0011 17.9 2.2 0.0016 17.3 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF2967 PF11179.6 T175606_2 - 0.93 8.8 15.8 2.1 7.6 15.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Rrn6 PF10214.7 T175606_2 - 0.99 7.6 4.7 1.6 6.9 4.7 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor TFIIA PF03153.11 T175606_2 - 1.9 8.2 14.5 3.8 7.3 14.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.12 T175606_2 - 5.7 6.7 5.9 9.1 6.0 5.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) ABC1 PF03109.14 T175606_3 - 2.7e-31 108.1 0.0 3.9e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 ABC1 family Ion_trans PF00520.29 T234052_3 - 6.9e-70 234.9 9.6 8.9e-70 234.6 9.6 1.1 1 0 0 1 1 1 1 Ion transport protein Tantalus PF15386.4 T204328_2 - 0.37 10.8 4.0 0.35 10.9 1.5 2.2 2 0 0 2 2 2 0 Drosophila Tantalus-like Pkinase PF00069.23 T117960_2 - 1.9e-72 243.6 0.0 2.6e-72 243.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T117960_2 - 5.2e-34 117.6 0.0 6.7e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.20 T117960_2 - 0.00011 21.8 0.2 0.00016 21.2 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 T117960_2 - 0.00067 18.9 0.1 0.0012 18.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AICARFT_IMPCHas PF01808.16 T207091_1 - 2.3e-95 319.3 0.1 3e-95 319.0 0.1 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.20 T207091_1 - 5e-25 87.4 0.0 8.7e-25 86.6 0.0 1.4 1 0 0 1 1 1 1 MGS-like domain Ribosomal_L12_N PF16320.3 T207091_1 - 0.012 15.2 0.6 0.012 15.2 0.6 1.9 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain HSP20 PF00011.19 T348817_1 - 0.00014 21.8 0.0 0.00025 21.0 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family LIN37 PF15306.4 T076379_2 - 0.057 13.5 0.2 0.11 12.6 0.2 1.3 1 0 0 1 1 1 0 LIN37 Mito_carr PF00153.25 T327900_3 - 1.5e-60 201.0 0.6 3.8e-20 71.5 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein PAX PF00292.16 T047366_3 - 4.7e-74 246.1 0.5 7.5e-74 245.5 0.5 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 T047366_3 - 7.8e-44 148.3 10.0 2.6e-43 146.6 10.0 1.9 1 0 0 1 1 1 1 Paired-box protein 2 C terminal HTH_32 PF13565.4 T047366_3 - 0.00071 20.0 1.4 0.17 12.4 0.0 4.0 2 1 1 3 3 3 2 Homeodomain-like domain HTH_23 PF13384.4 T047366_3 - 0.0009 18.8 0.0 0.0021 17.7 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain Homeobox PF00046.27 T047366_3 - 0.069 12.8 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Homeobox domain I-set PF07679.14 T265200_1 - 1.5e-09 37.7 0.0 1.3e-08 34.6 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T265200_1 - 6.3e-09 36.2 0.0 1.5e-08 35.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain IGFBP PF00219.16 T265200_1 - 4e-07 30.4 21.7 4e-07 30.4 21.7 2.7 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Kazal_2 PF07648.13 T265200_1 - 1.5e-05 24.9 1.4 1.5e-05 24.9 1.4 2.2 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 T265200_1 - 0.0002 21.2 0.4 0.00063 19.6 0.4 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain ig PF00047.23 T265200_1 - 0.00083 19.4 0.0 0.0019 18.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T265200_1 - 0.0015 18.7 0.0 0.0044 17.2 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 T265200_1 - 0.0026 17.7 0.6 0.0077 16.3 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain zf-H2C2_2 PF13465.4 T126241_1 - 2.1e-51 170.0 88.5 1.2e-09 38.0 0.6 12.1 12 0 0 12 12 12 8 Zinc-finger double domain zf-C2H2 PF00096.24 T126241_1 - 1.5e-47 157.3 93.7 6e-07 29.4 1.8 10.1 9 0 0 9 9 9 9 Zinc finger, C2H2 type SCAN PF02023.15 T126241_1 - 9.2e-40 134.2 2.8 1.7e-39 133.4 2.8 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2_4 PF13894.4 T126241_1 - 4.8e-26 89.0 82.5 0.0013 19.3 1.4 10.3 9 0 0 9 9 9 9 C2H2-type zinc finger KRAB PF01352.25 T126241_1 - 1.1e-12 47.3 0.1 2e-12 46.4 0.1 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 T126241_1 - 9.9e-06 25.5 38.6 0.0024 17.8 3.0 7.1 5 1 2 7 7 7 4 Zinc ribbon domain zf-C2H2_11 PF16622.3 T126241_1 - 0.00014 21.4 64.9 0.002 17.7 2.7 9.5 10 0 0 10 10 10 5 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 T126241_1 - 0.028 14.2 67.3 0.017 14.9 1.5 9.7 9 0 0 9 9 9 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T126241_1 - 0.1 13.2 30.0 0.87 10.2 0.8 5.0 3 2 2 5 5 5 0 zinc-ribbon family FYDLN_acid PF09538.8 T126241_1 - 1.6 9.3 12.1 34 5.1 0.1 6.0 3 2 4 7 7 7 0 Protein of unknown function (FYDLN_acid) 6PF2K PF01591.16 T036629_2 - 7.2e-107 355.6 0.2 1e-106 355.2 0.2 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 T036629_2 - 8.2e-40 136.5 0.0 1.1e-39 136.0 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 T036629_2 - 5.4e-07 29.7 0.4 2e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.8 T036629_2 - 0.00037 19.9 0.1 0.0006 19.2 0.1 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.4 T036629_2 - 0.13 12.6 0.1 0.34 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 T036629_2 - 0.18 10.9 0.2 0.49 9.5 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin SRP54 PF00448.20 T036629_2 - 0.2 11.2 0.5 0.36 10.3 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Ice_nucleation PF00818.15 T194977_1 - 2.4 8.3 5.3 11 6.2 5.3 2.3 1 0 0 1 1 1 0 Ice nucleation protein repeat CLZ PF16526.3 T194977_3 - 1.1e-29 102.4 6.7 2.2e-29 101.5 6.7 1.5 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ion_trans PF00520.29 T194977_3 - 2.3e-23 82.5 4.2 2.3e-23 82.5 4.2 1.7 2 0 0 2 2 2 1 Ion transport protein cNMP_binding PF00027.27 T194977_3 - 5.6e-17 61.4 0.0 9.3e-17 60.7 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 T194977_3 - 0.031 14.1 2.7 0.097 12.5 2.7 1.9 1 0 0 1 1 1 0 Ion channel Bromodomain PF00439.23 T243472_2 - 3.4e-111 363.4 32.5 9e-23 80.0 0.1 7.4 7 0 0 7 7 7 6 Bromodomain BAH PF01426.16 T243472_2 - 5.4e-50 168.2 3.3 2.7e-28 98.1 1.3 2.8 2 0 0 2 2 2 2 BAH domain HMG_box PF00505.17 T243472_2 - 6.2e-12 45.6 2.7 8.3e-12 45.2 0.0 2.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T243472_2 - 2.8e-07 30.9 0.0 7.8e-07 29.5 0.0 1.8 1 0 0 1 1 1 1 HMG-box domain Rhodanese PF00581.18 T233146_1 - 1e-24 87.0 0.0 5.8e-13 49.2 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain Connexin PF00029.17 T019756_3 - 5.7e-94 314.0 0.9 7.5e-94 313.6 0.9 1.1 1 0 0 1 1 1 1 Connexin Connexin40_C PF16791.3 T019756_3 - 4.1e-38 130.8 0.1 1.2e-37 129.2 0.1 1.8 2 0 0 2 2 2 1 Connexin 40 C-terminal domain ADIP PF11559.6 T014400_2 - 0.0001 22.3 19.9 0.0001 22.3 19.9 5.9 2 2 3 6 6 6 1 Afadin- and alpha -actinin-Binding APG6 PF04111.10 T014400_2 - 0.55 9.4 84.4 0.2 10.9 15.1 3.8 2 1 2 4 4 4 0 Autophagy protein Apg6 RWD PF05773.20 T015671_1 - 1.4e-11 44.6 0.1 2.1e-11 44.0 0.1 1.2 1 0 0 1 1 1 1 RWD domain ARL17 PF15840.3 T172614_1 - 1.1 9.5 6.8 1.1 9.5 0.8 3.2 3 0 0 3 3 3 0 ADP-ribosylation factor-like protein 17 Glyco_transf_29 PF00777.16 T009544_3 - 1.9e-67 227.3 0.0 2.7e-67 226.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) JmjC PF02373.20 T009544_3 - 1.1e-41 141.7 0.1 2.3e-41 140.7 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.4 T009544_3 - 4.1e-32 110.5 8.2 4.1e-32 110.5 8.2 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 T009544_3 - 2.7e-14 53.0 5.3 2.7e-14 53.0 5.3 2.9 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.4 T009544_3 - 8.1e-14 50.7 4.7 8.1e-14 50.7 4.7 3.7 4 0 0 4 4 4 1 PHD-finger JmjN PF02375.15 T009544_3 - 2.1e-13 49.8 0.0 4.4e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 jmjN domain TGF_beta PF00019.18 T009544_3 - 1.8e-10 41.5 0.0 4.6e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 Transforming growth factor beta like domain PHD PF00628.27 T009544_3 - 8.3e-06 25.5 1.4 8.3e-06 25.5 1.4 4.6 5 0 0 5 5 5 2 PHD-finger LBR_tudor PF09465.8 T009544_3 - 0.002 17.7 1.2 0.08 12.6 0.2 2.5 2 0 0 2 2 2 1 Lamin-B receptor of TUDOR domain GCV_T PF01571.19 T135364_1 - 2.1e-47 161.6 0.0 3e-47 161.0 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.22 T135364_1 - 4.5e-36 125.0 0.1 1.2e-26 94.0 0.1 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase GCV_T_C PF08669.9 T135364_1 - 2e-21 75.9 0.0 4.1e-21 74.9 0.0 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain FAO_M PF16350.3 T135364_1 - 1.3e-16 60.5 0.1 2.7e-16 59.5 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain Pyr_redox_2 PF07992.12 T135364_1 - 0.00027 20.2 0.0 0.00043 19.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 T135364_1 - 0.0053 15.8 0.0 0.0077 15.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.4 T135364_1 - 0.02 15.0 0.2 0.045 13.9 0.2 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.15 T135364_1 - 0.13 11.3 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Acyl_transf_1 PF00698.19 T156822_1 - 1e-115 386.5 0.0 1.7e-115 385.8 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.24 T156822_1 - 9.7e-72 241.4 0.0 1.7e-71 240.6 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thioesterase PF00975.18 T156822_1 - 2.8e-64 217.2 0.1 2.8e-64 217.2 0.1 2.4 2 0 0 2 2 2 1 Thioesterase domain KR PF08659.8 T156822_1 - 9.3e-47 159.1 0.0 2.3e-46 157.8 0.0 1.7 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.20 T156822_1 - 5.6e-37 126.2 0.0 1e-36 125.4 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.3 T156822_1 - 1.7e-35 121.7 0.0 4.2e-35 120.5 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.24 T156822_1 - 1.4e-18 66.9 0.0 2.6e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PS-DH PF14765.4 T156822_1 - 6e-18 65.0 0.1 1.2e-17 64.0 0.1 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase ADH_zinc_N_2 PF13602.4 T156822_1 - 6.2e-15 56.3 0.0 1.5e-14 55.0 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.23 T156822_1 - 1.7e-09 37.7 1.9 3.3e-09 36.8 1.9 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_12 PF08242.10 T156822_1 - 2.6e-07 31.1 0.0 5.4e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 T156822_1 - 6.4e-06 25.9 0.0 2.7e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.23 T156822_1 - 6e-05 22.5 0.0 0.00019 20.8 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase Thiolase_N PF00108.21 T156822_1 - 0.00051 19.3 0.0 0.00089 18.6 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.10 T156822_1 - 0.0011 19.4 0.0 0.0031 18.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 T156822_1 - 0.0032 17.2 0.0 0.0067 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain YjeF_N PF03853.13 T156822_1 - 0.07 12.9 0.1 0.35 10.6 0.0 2.0 2 0 0 2 2 2 0 YjeF-related protein N-terminus Tropomyosin_1 PF12718.5 T156822_3 - 1.2 9.2 5.7 2.3 8.2 0.0 2.6 2 0 0 2 2 2 0 Tropomyosin like RFX1_trans_act PF04589.11 T355045_3 - 2.8e-36 124.9 25.1 7.2e-36 123.6 25.1 1.7 1 0 0 1 1 1 1 RFX1 transcription activation region RFX_DNA_binding PF02257.13 T355045_3 - 1.3e-32 112.1 0.1 2.8e-32 111.1 0.1 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain GCIP PF13324.4 T145519_3 - 5.1e-07 29.4 0.2 7.1e-07 29.0 0.2 1.1 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting FWWh PF14922.4 T233724_3 - 3.1e-24 85.5 6.8 1.4e-17 63.9 1.0 2.4 1 1 1 2 2 2 2 Protein of unknown function Fe_hyd_lg_C PF02906.12 T157066_1 - 6.5e-13 48.8 0.0 9.4e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.15 T157066_1 - 1e-10 41.4 0.0 2.8e-10 40.0 0.0 1.7 2 0 0 2 2 2 1 Iron hydrogenase small subunit Fe_hyd_lg_C PF02906.12 T157066_3 - 3.5e-44 151.2 0.0 5.5e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain BAT2_N PF07001.9 T367853_1 - 1.1e-66 224.8 8.8 1.1e-66 224.8 8.8 5.0 5 0 0 5 5 5 1 BAT2 N-terminus GDPD PF03009.15 T130162_1 - 0.0012 18.6 0.0 0.0019 17.9 0.0 1.3 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.4 T130162_1 - 0.002 18.5 0.0 0.0042 17.4 0.0 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD PF03009.15 T130162_2 - 1.7e-18 67.1 0.0 2.3e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Pkinase PF00069.23 T130162_3 - 1.8e-68 230.7 0.0 2.1e-68 230.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T130162_3 - 3.2e-33 115.0 0.0 4.2e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 T130162_3 - 0.0014 18.4 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.12 T130162_3 - 0.14 11.3 0.3 0.22 10.7 0.3 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CUB PF00431.18 T349643_1 - 0 1084.1 0.0 8.4e-26 90.3 0.0 14.3 14 0 0 14 14 14 14 CUB domain Sushi PF00084.18 T349643_1 - 6.2e-251 811.2 172.6 2.4e-11 43.9 0.4 28.5 28 0 0 28 28 28 28 Sushi repeat (SCR repeat) CUB_2 PF02408.18 T349643_1 - 1.3e-19 70.0 18.9 0.041 13.5 0.3 12.1 13 0 0 13 13 13 7 CUB-like domain HRM PF02793.20 T349643_1 - 0.68 10.1 76.8 1.5 9.0 0.2 14.5 14 1 1 15 15 15 0 Hormone receptor domain Engrail_1_C_sig PF10525.7 T272459_1 - 0.15 11.2 0.3 0.3 10.2 0.3 1.4 1 0 0 1 1 1 0 Engrailed homeobox C-terminal signature domain MH2 PF03166.12 T272459_2 - 1.8e-75 253.1 1.5 2.4e-75 252.7 1.5 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 T272459_2 - 1.7e-41 140.5 1.2 3.2e-41 139.6 1.2 1.5 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 T272459_2 - 0.00088 19.0 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 Pkinase PF00069.23 T208172_1 - 5.1e-109 363.6 0.0 4.2e-55 186.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain I-set PF07679.14 T208172_1 - 2.2e-99 325.6 0.0 5.3e-21 74.4 0.0 6.3 6 0 0 6 6 6 6 Immunoglobulin I-set domain ASC PF00858.22 T208172_1 - 1.8e-61 208.2 0.0 2.6e-61 207.7 0.0 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Ig_3 PF13927.4 T208172_1 - 2e-55 185.2 0.0 2.4e-10 40.7 0.0 6.9 6 0 0 6 6 6 6 Immunoglobulin domain Pkinase_Tyr PF07714.15 T208172_1 - 4.8e-50 170.1 0.0 1.3e-26 93.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Ig_2 PF13895.4 T208172_1 - 5.1e-32 109.9 0.2 1.6e-05 25.0 0.0 7.6 7 0 0 7 7 7 6 Immunoglobulin domain ig PF00047.23 T208172_1 - 1.6e-28 98.6 0.0 0.00034 20.6 0.0 6.6 6 0 0 6 6 6 5 Immunoglobulin domain NTP_transferase PF00483.21 T208172_1 - 1.8e-27 96.3 0.0 2.6e-27 95.8 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase fn3 PF00041.19 T208172_1 - 5.9e-08 32.8 0.2 0.013 15.6 0.1 2.6 2 0 0 2 2 2 2 Fibronectin type III domain NTP_transf_3 PF12804.5 T208172_1 - 2.8e-07 30.9 0.0 6e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain V-set PF07686.15 T208172_1 - 2.3e-05 24.4 0.6 0.091 12.8 0.0 5.2 5 1 0 5 5 5 1 Immunoglobulin V-set domain Hexapep PF00132.22 T208172_1 - 2.5e-05 23.7 2.6 5.1e-05 22.7 0.3 2.4 2 0 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) C2-set_2 PF08205.10 T208172_1 - 0.00044 20.1 0.0 7.9 6.5 0.0 4.6 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Kdo PF06293.12 T208172_1 - 0.019 14.2 0.7 0.047 12.9 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Izumo-Ig PF16706.3 T208172_1 - 0.026 14.5 1.6 2.5 8.0 0.1 3.9 5 0 0 5 5 3 0 Izumo-like Immunoglobulin domain APH PF01636.21 T208172_1 - 0.11 12.3 1.7 1.3 8.8 0.0 3.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kinase-like PF14531.4 T208172_1 - 0.14 11.3 0.0 0.29 10.3 0.0 1.5 2 0 0 2 2 2 0 Kinase-like DUF4954 PF16314.3 T208172_1 - 0.24 9.4 0.1 0.34 8.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) I-set PF07679.14 T208172_2 - 6.1e-15 54.9 0.0 9.3e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T208172_2 - 7.8e-08 32.7 0.0 1.9e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 T208172_2 - 0.0015 18.7 0.0 0.0033 17.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 T208172_3 - 4.8e-64 212.3 0.0 1.5e-21 76.1 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin I-set domain Ig_3 PF13927.4 T208172_3 - 1.2e-37 128.2 0.0 1.6e-10 41.3 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain SPEG_u2 PF16650.3 T208172_3 - 1.2e-31 108.6 14.4 3.9e-31 106.9 14.4 2.0 1 0 0 1 1 1 1 Unstructured region on SPEG complex protein ASC PF00858.22 T208172_3 - 1.4e-24 86.7 0.0 1.4e-24 86.7 0.0 1.4 2 0 0 2 2 2 1 Amiloride-sensitive sodium channel Ig_2 PF13895.4 T208172_3 - 1.5e-22 79.6 0.0 7.3e-07 29.3 0.0 4.1 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 T208172_3 - 1.4e-19 69.9 0.0 3.1e-06 27.1 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 T208172_3 - 2.4e-06 27.5 0.0 0.76 9.8 0.0 4.0 3 2 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 T208172_3 - 0.00096 19.1 0.9 2.7 8.0 0.0 3.8 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain HMG_box PF00505.17 T055402_3 - 1.2e-21 76.7 4.5 2.5e-21 75.7 4.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T055402_3 - 8.7e-09 35.7 1.1 8.7e-09 35.7 1.1 2.3 2 0 0 2 2 2 1 HMG-box domain MPS2 PF17060.3 T055402_3 - 0.24 10.5 10.7 0.41 9.7 10.7 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF4500 PF14937.4 T307701_2 - 3.6e-36 122.9 0.0 7.2e-36 121.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4500) MBD PF01429.17 T080614_1 - 0.046 13.3 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyl-CpG binding domain RRXRR PF14239.4 T080614_1 - 0.16 11.7 2.5 0.31 10.8 2.5 1.3 1 0 0 1 1 1 0 RRXRR protein DENN PF02141.19 T017326_1 - 8e-58 195.3 1.8 1.3e-57 194.7 1.8 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 T017326_1 - 1.5e-14 54.4 0.0 3.1e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 T017326_1 - 1.3e-10 40.9 2.0 3.3e-10 39.7 2.0 1.7 1 0 0 1 1 1 1 dDENN domain zf-H2C2_2 PF13465.4 T329416_3 - 2.1e-66 217.4 46.7 4.8e-08 33.0 0.1 10.1 9 0 0 9 9 9 9 Zinc-finger double domain zf-C2H2 PF00096.24 T329416_3 - 2.4e-44 147.2 58.0 3.7e-06 27.0 0.8 10.0 9 0 0 9 9 9 8 Zinc finger, C2H2 type KRAB PF01352.25 T329416_3 - 2.8e-23 81.2 0.2 5.1e-23 80.3 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T329416_3 - 1.7e-22 78.0 53.0 0.025 15.3 1.3 9.2 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T329416_3 - 3.6e-13 49.0 40.1 0.0051 16.6 0.4 9.0 8 0 0 8 8 8 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T329416_3 - 8.9e-07 28.8 38.4 0.0026 17.7 1.7 5.7 1 1 5 7 7 7 6 Zinc ribbon domain XPA_N PF01286.16 T329416_3 - 0.0026 17.6 35.1 5.1 7.1 0.2 8.4 8 0 0 8 8 8 2 XPA protein N-terminal zf-C2H2_11 PF16622.3 T329416_3 - 0.051 13.2 35.0 3.7 7.3 0.2 7.8 7 0 0 7 7 7 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 T329416_3 - 0.18 12.0 26.3 0.42 10.8 0.4 7.3 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding HGWP PF03578.13 T152105_2 - 3.2 7.4 11.6 0.073 12.6 3.8 2.4 2 0 0 2 2 2 0 HGWP repeat Pkinase PF00069.23 T152105_3 - 1.2e-27 96.8 0.0 1.6e-27 96.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T152105_3 - 1.9e-21 76.4 0.0 2.8e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase LIM PF00412.20 T152105_3 - 2.2e-09 37.2 9.9 4.5e-09 36.3 9.9 1.5 1 0 0 1 1 1 1 LIM domain Ank_2 PF12796.5 T084794_2 - 1.5e-37 127.9 6.6 1.4e-12 47.9 0.5 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 T084794_2 - 1.5e-35 120.5 9.0 1.2e-07 31.7 0.1 6.8 2 1 5 7 7 7 6 Ankyrin repeats (many copies) SAM_1 PF00536.28 T084794_2 - 1.2e-34 118.4 1.0 6.2e-16 58.5 0.1 2.7 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) Ank_4 PF13637.4 T084794_2 - 9.5e-32 108.8 6.4 3.6e-08 33.7 0.1 4.9 5 0 0 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 T084794_2 - 4.6e-30 100.2 2.7 9.7e-05 22.4 0.0 7.6 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.28 T084794_2 - 1.8e-28 97.5 8.7 9.1e-05 22.6 0.0 6.9 6 0 0 6 6 6 6 Ankyrin repeat SAM_2 PF07647.15 T084794_2 - 5.1e-28 96.8 0.4 8.1e-15 54.5 0.1 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.21 T084794_2 - 4.9e-20 71.9 0.7 9.2e-20 71.0 0.7 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 T084794_2 - 0.00033 20.7 0.1 0.0006 19.8 0.1 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.4 T084794_2 - 0.0079 15.9 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SWIB PF02201.16 T336013_1 - 1.1e-14 53.9 0.0 1.8e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 SWIB/MDM2 domain TAF1D PF15333.4 T088728_1 - 0.88 9.1 7.7 1.9 8.1 7.7 1.4 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D GPS2_interact PF15784.3 T088728_3 - 2.1e-38 130.8 7.2 2.1e-38 130.8 7.2 4.6 4 1 0 4 4 4 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 T088728_3 - 7.1e-19 67.6 0.5 1.9e-11 43.8 0.2 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 T088728_3 - 0.013 15.6 0.5 0.013 15.6 0.5 3.0 3 0 0 3 3 3 0 Myb-like DNA-binding domain Serinc PF03348.13 T088728_3 - 0.57 8.9 3.5 1 8.1 3.5 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4518 PF15008.4 T088728_3 - 3.6 6.6 13.6 0.45 9.5 7.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) LRR_8 PF13855.4 T179250_2 - 6.8e-41 137.7 24.0 2.4e-14 52.7 2.5 4.7 2 2 1 4 4 4 4 Leucine rich repeat Josephin PF02099.15 T179250_2 - 6.4e-24 84.7 0.0 3.1e-23 82.5 0.0 2.0 1 1 0 1 1 1 1 Josephin DUF108 PF01958.16 T179250_2 - 6.2e-22 77.6 0.6 3.1e-21 75.4 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function DUF108 LRR_5 PF13306.4 T179250_2 - 1e-19 70.6 0.0 1.3e-12 47.7 0.0 2.2 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 T179250_2 - 5.3e-19 67.8 30.4 3.4e-05 23.9 0.3 6.3 3 1 4 8 8 8 7 Leucine Rich repeats (2 copies) I-set PF07679.14 T179250_2 - 3.4e-15 55.7 0.0 5.2e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T179250_2 - 1.1e-11 45.1 0.2 2.1e-11 44.1 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T179250_2 - 3e-09 36.8 0.7 5.4e-09 36.0 0.7 1.4 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.4 T179250_2 - 3.4e-09 36.3 4.8 4.5e-06 26.1 0.3 2.2 1 1 0 2 2 2 2 Leucine-rich repeat LRRNT PF01462.16 T179250_2 - 2.9e-05 23.4 3.1 0.00013 21.4 3.1 2.3 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain V-set PF07686.15 T179250_2 - 5e-05 23.3 1.6 0.00036 20.5 1.6 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T179250_2 - 6.8e-05 23.0 0.4 0.00015 21.9 0.4 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 T179250_2 - 0.55 10.8 23.7 7 7.4 0.0 6.5 6 1 0 6 6 5 0 Leucine Rich Repeat TMEM132 PF16070.3 T145688_3 - 1.4e-133 445.4 1.9 1.8e-133 445.0 1.9 1.1 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_N PF15705.3 T145688_3 - 6.6e-51 171.4 0.3 1e-50 170.8 0.3 1.3 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term TMEM132D_C PF15706.3 T145688_3 - 1.2e-29 101.8 0.0 2.8e-29 100.6 0.0 1.6 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Pinin_SDK_N PF04697.11 T145688_3 - 4.9 7.7 6.3 0.85 10.1 0.8 2.1 2 0 0 2 2 2 0 pinin/SDK conserved region EAP30 PF04157.14 T094923_1 - 6.5e-34 117.1 0.9 9.1e-34 116.6 0.9 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.6 T094923_2 - 8.1e-06 25.8 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 TSP_1 PF00090.17 T094923_3 - 1.2e-09 38.1 6.4 4.5e-09 36.3 6.4 2.1 1 0 0 1 1 1 1 Thrombospondin type 1 domain Kinesin PF00225.21 T034488_1 - 1.3e-57 195.1 0.0 1.9e-57 194.6 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 T034488_1 - 4.7e-15 55.7 0.0 8.2e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding zf-H2C2_2 PF13465.4 T318198_1 - 1.6e-29 100.8 28.0 4.1e-08 33.2 0.4 6.2 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.24 T318198_1 - 8.8e-26 88.8 29.6 9.6e-06 25.7 0.7 5.8 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T318198_1 - 1.4e-15 56.4 28.2 0.0044 17.6 0.5 6.1 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T318198_1 - 6.8e-06 26.1 9.2 0.027 14.6 0.3 4.9 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 T318198_1 - 0.092 13.4 7.5 4.9 7.8 2.3 3.3 1 1 1 2 2 2 0 zinc-ribbon family Zn-ribbon_8 PF09723.8 T318198_1 - 0.28 11.2 18.0 0.34 10.9 3.1 4.2 1 1 5 6 6 6 0 Zinc ribbon domain zf-C2H2_6 PF13912.4 T318198_1 - 0.85 9.5 23.6 2.8 7.9 0.7 5.4 5 0 0 5 5 5 0 C2H2-type zinc finger Zn_ribbon_recom PF13408.4 T318198_1 - 6.5 7.2 20.6 9.5 6.7 3.3 4.0 2 2 2 4 4 4 0 Recombinase zinc beta ribbon domain C1_4 PF07975.10 T318198_1 - 6.8 6.9 9.1 3.3 7.9 0.4 3.3 2 1 1 3 3 3 0 TFIIH C1-like domain ATG16 PF08614.9 T300372_2 - 0.018 15.1 8.4 0.027 14.5 8.4 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.6 T300372_2 - 0.035 13.3 2.3 0.051 12.7 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4763 PF15960.3 T300372_2 - 0.041 13.0 4.8 0.063 12.4 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) DUF2968 PF11180.6 T300372_2 - 0.051 13.1 3.8 0.073 12.6 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) HAUS-augmin3 PF14932.4 T300372_2 - 0.12 11.7 3.1 0.19 11.1 3.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 TMF_DNA_bd PF12329.6 T300372_2 - 0.47 10.3 5.8 0.96 9.4 5.8 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding IncA PF04156.12 T300372_2 - 0.53 9.9 6.8 0.81 9.3 6.8 1.2 1 0 0 1 1 1 0 IncA protein Spc7 PF08317.9 T300372_2 - 2.1 7.0 6.0 3 6.5 6.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.7 T300372_2 - 3.7 7.8 4.6 30 4.9 4.5 2.0 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FtsJ PF01728.17 T302808_1 - 1.6e-36 126.0 0.0 2.6e-36 125.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase G-patch PF01585.21 T302808_1 - 1.2e-12 47.3 1.7 3.2e-12 46.0 1.7 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 T302808_1 - 0.01 15.8 1.0 0.02 14.8 1.0 1.4 1 0 0 1 1 1 0 G-patch domain mRNA_cap_enzyme PF01331.17 T302808_1 - 0.016 14.9 0.1 0.028 14.1 0.1 1.2 1 0 0 1 1 1 0 mRNA capping enzyme, catalytic domain DNA_ligase_A_M PF01068.19 T302808_1 - 0.094 12.2 0.1 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 ATP dependent DNA ligase domain WW PF00397.24 T302808_1 - 0.097 12.5 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 WW domain FHA PF00498.24 T302808_2 - 9e-13 48.2 0.0 1.7e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-C3HC4_3 PF13920.4 T302808_2 - 8.1e-09 35.1 8.7 8.1e-09 35.1 8.7 3.0 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T302808_2 - 1.3e-08 34.4 8.9 6.9e-08 32.1 8.9 2.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 T302808_2 - 2e-08 33.8 11.5 2e-08 33.8 11.5 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T302808_2 - 4.4e-07 29.9 10.2 4.4e-07 29.9 10.2 3.6 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_4 PF15227.4 T302808_2 - 7.1e-07 29.2 11.5 3.6e-06 26.9 11.5 2.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.5 T302808_2 - 9.1e-06 25.7 5.1 3.1e-05 24.0 5.1 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.4 T302808_2 - 8.4e-05 22.2 6.9 8.4e-05 22.2 6.9 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 T302808_2 - 0.00011 22.0 9.6 0.00011 22.0 9.6 3.0 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 T302808_2 - 0.00017 21.4 4.9 0.00017 21.4 4.9 2.3 2 0 0 2 2 2 1 RING-type zinc-finger Yop-YscD_cpl PF16697.3 T302808_2 - 0.0064 16.6 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_6 PF14835.4 T302808_2 - 0.027 14.2 4.8 0.082 12.7 4.8 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.5 T302808_2 - 0.04 13.8 2.5 0.1 12.6 2.5 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.3 T302808_2 - 0.078 13.0 6.9 0.27 11.3 6.9 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 Golgin_A5 PF09787.7 T302808_2 - 0.56 9.5 28.1 0.87 8.9 28.1 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Phage_30_3 PF08010.9 T302808_2 - 1.2 8.8 5.1 2.8 7.6 5.1 1.6 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 zf-Nse PF11789.6 T302808_2 - 2.9 7.7 8.7 6.8 6.5 5.2 2.4 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-H2C2_2 PF13465.4 T167881_3 - 1.7e-97 315.7 118.1 1.6e-08 34.5 1.2 18.4 19 1 1 20 20 19 15 Zinc-finger double domain zf-C2H2 PF00096.24 T167881_3 - 3.6e-66 216.0 118.1 2.2e-07 30.8 1.0 16.8 17 0 0 17 17 17 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T167881_3 - 4.8e-40 132.6 111.8 0.00044 20.7 1.0 16.7 17 0 0 17 17 17 12 C2H2-type zinc finger KRAB PF01352.25 T167881_3 - 1.8e-24 85.0 0.1 4e-24 83.9 0.1 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T167881_3 - 1.7e-16 59.6 97.6 0.019 14.8 1.2 14.7 16 0 0 16 16 15 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T167881_3 - 1.1e-14 54.2 70.5 0.0016 18.6 0.1 13.9 14 0 0 14 14 14 7 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T167881_3 - 3.7e-13 48.8 68.0 0.0036 16.9 0.8 14.0 14 0 0 14 14 14 7 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T167881_3 - 9e-07 28.8 74.8 0.064 13.3 4.5 11.2 7 4 6 14 14 14 9 Zinc ribbon domain XPA_N PF01286.16 T167881_3 - 6.7e-06 25.9 70.4 1.2 9.1 0.0 13.6 14 0 0 14 14 14 5 XPA protein N-terminal zf-trcl PF13451.4 T167881_3 - 0.00023 20.9 57.7 1.5 8.6 3.6 12.7 12 2 0 12 12 12 4 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 T167881_3 - 0.038 14.6 67.9 0.13 12.9 2.0 8.3 4 1 6 10 10 9 0 zinc-ribbon family Mito_carr PF00153.25 T378270_3 - 6.2e-21 74.0 0.2 1.3e-06 28.1 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein SNARE PF05739.17 T221049_3 - 5.3e-19 67.8 3.1 1.2e-18 66.7 3.1 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.23 T221049_3 - 1.2e-07 31.5 3.7 1.9e-07 30.8 3.7 1.3 1 0 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.19 T221049_3 - 0.29 10.8 2.6 0.65 9.7 2.6 1.6 1 0 0 1 1 1 0 Synaptobrevin DUF2116 PF09889.7 T221049_3 - 0.46 10.4 2.8 1.8 8.4 2.8 2.1 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) MCPsignal PF00015.19 T221049_3 - 0.49 10.0 1.4 0.98 9.0 0.1 1.8 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Ribosomal_L6 PF00347.21 T263680_1 - 9.7e-33 112.6 1.4 2.6e-15 56.7 0.3 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 Glyco_transf_6 PF03414.11 T368100_1 - 3.2e-108 361.2 0.0 4.6e-108 360.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 6 RasGEF PF00617.17 T368100_1 - 1.7e-54 184.5 0.2 2.4e-54 183.9 0.2 1.2 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 T368100_1 - 3.2e-20 72.2 0.0 6.5e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 T368100_1 - 2.2e-14 53.7 0.0 7.5e-14 52.0 0.1 1.9 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Glyco_transf_6 PF03414.11 T368100_2 - 2.5e-20 72.4 0.0 3.7e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 6 zf-HIT PF04438.14 T061021_1 - 3.9e-11 42.5 9.5 8.2e-11 41.4 9.5 1.6 1 0 0 1 1 1 1 HIT zinc finger YL1_C PF08265.9 T061021_1 - 0.0046 16.6 0.3 0.008 15.8 0.3 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Arm_2 PF04826.11 T377952_2 - 6.3e-55 186.2 4.2 8.9e-55 185.8 4.2 1.1 1 0 0 1 1 1 1 Armadillo-like BRCT_assoc PF12820.5 T148091_2 - 2.2e-81 271.3 1.3 2.2e-81 271.3 1.3 3.1 2 0 0 2 2 2 1 Serine-rich domain associated with BRCT BRCT PF00533.24 T148091_2 - 1.5e-18 66.8 0.0 8.3e-09 35.6 0.0 3.0 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-C3HC4 PF00097.23 T148091_2 - 1.8e-09 37.2 10.7 6.1e-09 35.5 10.7 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 T148091_2 - 5.9e-09 35.5 11.1 1.7e-08 34.0 11.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 T148091_2 - 1.4e-07 31.4 10.7 4.4e-07 29.8 10.7 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 T148091_2 - 4.8e-07 29.4 7.6 1.2e-06 28.2 7.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 T148091_2 - 1e-06 28.5 9.0 3.2e-06 26.9 9.0 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 T148091_2 - 3.7e-06 27.0 8.6 3.7e-06 27.0 8.6 2.4 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 T148091_2 - 1.5e-05 24.7 8.7 4.7e-05 23.1 8.7 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.6 T148091_2 - 0.00025 20.7 7.4 0.00075 19.1 7.4 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 T148091_2 - 0.00045 19.9 2.1 0.001 18.8 2.1 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein BRCT_2 PF16589.3 T148091_2 - 0.00089 19.5 0.0 0.43 10.9 0.0 2.8 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain zf-ANAPC11 PF12861.5 T148091_2 - 0.0028 17.6 1.6 0.0061 16.4 1.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 T148091_2 - 0.0031 17.2 9.1 0.0076 16.0 8.0 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 T148091_2 - 0.0054 16.7 7.0 0.015 15.2 7.0 1.8 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.5 T148091_2 - 0.02 15.1 5.0 0.068 13.3 5.0 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.4 T148091_2 - 0.93 9.1 7.1 2.5 7.8 7.1 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Pkinase PF00069.23 T378781_3 - 1.2e-71 241.1 0.0 2e-71 240.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T378781_3 - 1.2e-44 152.4 0.0 2e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 T378781_3 - 1.1e-22 80.1 0.0 2.2e-22 79.1 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 T378781_3 - 1.1e-05 24.7 0.0 0.0024 17.1 0.0 2.4 1 1 1 2 2 2 2 Kinase-like Ribosomal_60s PF00428.17 T378781_3 - 0.11 12.9 2.4 0.27 11.7 2.4 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein DSHCT PF08148.10 T378781_3 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain APH PF01636.21 T378781_3 - 0.15 11.8 0.1 0.44 10.3 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family CCDC24 PF15669.3 T009646_1 - 1.2e-36 126.3 0.7 2.9e-36 125.1 0.7 1.6 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family Glyco_transf_7N PF13733.4 T009646_3 - 7.7e-55 184.1 0.0 1.2e-54 183.4 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 T009646_3 - 1.4e-30 104.6 2.8 2.2e-30 104.0 0.4 2.3 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase CCDC24 PF15669.3 T009646_3 - 9e-22 77.8 0.0 9e-22 77.8 0.0 1.8 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 24 family Glyco_tranf_2_2 PF10111.7 T009646_3 - 0.045 13.1 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 YlbE PF14003.4 T209985_1 - 2.1 8.7 0.0 2.1 8.7 0.0 3.4 3 0 0 3 3 3 0 YlbE-like protein DUF1725 PF08333.9 T209985_2 - 2.6e-06 26.8 0.3 4.6e-06 26.0 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) HEAT PF02985.20 T209985_2 - 0.025 14.6 0.5 1.1 9.6 0.1 3.3 3 0 0 3 3 3 0 HEAT repeat HEAT_2 PF13646.4 T209985_2 - 0.04 14.2 0.2 0.89 9.8 0.0 2.3 2 0 0 2 2 2 0 HEAT repeats HEAT_EZ PF13513.4 T209985_2 - 0.14 12.5 1.0 13 6.3 0.1 2.6 2 0 0 2 2 2 0 HEAT-like repeat RhoGAP PF00620.25 T217627_2 - 3.5e-39 133.9 0.2 5.2e-39 133.4 0.2 1.2 1 0 0 1 1 1 1 RhoGAP domain Kelch_1 PF01344.23 T064116_1 - 1.7e-24 85.0 0.0 2.7e-07 29.9 0.0 4.7 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.4 T064116_1 - 4e-17 61.7 0.1 0.0026 17.9 0.0 4.7 2 1 2 4 4 4 4 Kelch motif Kelch_3 PF13415.4 T064116_1 - 1.3e-09 38.0 6.8 0.016 15.4 0.0 6.8 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.4 T064116_1 - 4.8e-08 32.7 0.0 1.4 8.8 0.0 4.8 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.4 T064116_1 - 0.00019 21.2 0.0 5.4 7.0 0.0 3.9 3 0 0 3 3 3 2 Kelch motif BACK PF07707.13 T064116_2 - 7.8e-25 86.8 0.0 1.3e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 T064116_2 - 2.5e-14 53.3 0.0 4.1e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.23 T064116_2 - 5.8e-10 38.5 0.0 1.8e-05 24.1 0.1 2.8 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.4 T064116_2 - 0.016 15.3 1.1 5.1 7.4 0.2 2.9 1 1 1 2 2 2 0 Kelch motif Kelch_2 PF07646.13 T064116_2 - 0.049 13.5 1.1 1.9 8.5 0.1 3.0 3 0 0 3 3 3 0 Kelch motif GDPD PF03009.15 T064116_3 - 1.6e-15 57.4 0.0 4.1e-15 56.1 0.0 1.6 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.4 T064116_3 - 0.023 15.1 0.0 0.044 14.2 0.0 1.5 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Ras PF00071.20 T022235_3 - 1.3e-49 167.8 0.0 1.8e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T022235_3 - 7.9e-17 61.5 0.0 1.3e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 T022235_3 - 1.7e-07 30.7 0.0 2.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Kazal_1 PF00050.19 T290957_3 - 5.6e-17 61.4 6.1 1.7e-16 59.8 6.1 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 T290957_3 - 5.1e-11 42.4 2.1 1.5e-10 41.0 2.1 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Omega-toxin PF06357.9 T290957_3 - 0.097 12.4 2.3 0.42 10.3 2.3 2.1 1 0 0 1 1 1 0 Omega-atracotoxin DUF3915 PF13054.4 T290957_3 - 5.4 6.9 6.0 10 6.0 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) ABC_membrane PF00664.21 T075113_2 - 1.6e-66 224.7 37.2 1.3e-36 126.5 6.9 2.9 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 T075113_2 - 9.5e-51 171.8 0.0 6.9e-24 84.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 T075113_2 - 1.3e-06 27.9 2.1 0.099 11.9 0.1 3.8 3 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 T075113_2 - 0.00012 21.9 1.0 2 8.0 0.0 3.4 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 T075113_2 - 0.00043 20.1 0.1 0.091 12.5 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 T075113_2 - 0.0023 17.5 1.1 0.48 10.1 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.21 T075113_2 - 0.01 15.8 0.1 2.8 7.9 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_25 PF13481.4 T075113_2 - 0.073 12.5 0.0 0.79 9.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.4 T075113_2 - 0.08 13.3 7.4 2.6 8.4 4.3 2.7 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.4 T075113_2 - 0.095 12.8 0.0 10 6.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.15 T075113_2 - 0.13 11.9 0.2 13 5.3 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein Zeta_toxin PF06414.10 T075113_2 - 0.17 11.0 0.0 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin Palm_thioest PF02089.13 T301413_1 - 3.1e-14 52.7 0.0 4.9e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.18 T301413_1 - 1.6e-05 24.6 0.1 2.8e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.12 T301413_1 - 0.006 16.0 0.0 0.012 14.9 0.0 1.4 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.11 T301413_1 - 0.055 13.0 0.0 0.12 12.0 0.0 1.4 2 0 0 2 2 2 0 PGAP1-like protein EMI PF07546.11 T301413_2 - 1.8e-16 60.5 10.2 1.8e-16 60.5 10.2 2.5 2 0 0 2 2 2 1 EMI domain EGF PF00008.25 T301413_2 - 7.5e-07 29.2 20.0 0.00045 20.3 7.0 3.6 2 0 0 2 2 2 2 EGF-like domain EGF_CA PF07645.13 T301413_2 - 3.6e-06 26.9 5.0 3.6e-06 26.9 5.0 3.1 2 0 0 2 2 2 1 Calcium-binding EGF domain FXa_inhibition PF14670.4 T301413_2 - 1.2e-05 25.3 7.4 1.2e-05 25.3 7.4 3.2 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site hEGF PF12661.5 T301413_2 - 0.0098 16.4 5.6 0.0098 16.4 5.6 3.7 2 0 0 2 2 2 1 Human growth factor-like EGF PEHE PF15275.4 T147032_2 - 1.2e-27 96.9 1.1 1.2e-27 96.9 1.1 2.3 2 0 0 2 2 2 1 PEHE domain MSL1_dimer PF16801.3 T147032_2 - 3.5e-18 64.9 14.7 6.4e-18 64.1 14.7 1.5 1 0 0 1 1 1 1 Dimerisation domain of Male-specific-Lethal 1 Herpes_UL6 PF01763.14 T147032_2 - 0.14 10.5 1.7 0.2 10.0 1.7 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Laminin_I PF06008.12 T147032_2 - 0.15 11.6 7.9 0.23 11.0 7.9 1.2 1 0 0 1 1 1 0 Laminin Domain I DivIC PF04977.13 T147032_2 - 1.3 8.7 8.0 2.6 7.7 8.0 1.5 1 0 0 1 1 1 0 Septum formation initiator KLRAQ PF10205.7 T147032_2 - 2.5 8.3 11.2 5.5 7.2 10.2 1.9 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF3287 PF11690.6 T147032_2 - 2.5 7.7 4.5 6 6.5 4.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) GrpE PF01025.17 T147032_2 - 4 6.9 7.2 6.9 6.2 7.2 1.2 1 0 0 1 1 1 0 GrpE zf-H2C2_2 PF13465.4 T167693_2 - 3.7e-64 210.3 64.2 1.1e-08 34.9 0.8 10.6 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 T167693_2 - 7.7e-43 142.5 88.5 5.1e-06 26.5 0.8 11.2 11 0 0 11 11 11 9 Zinc finger, C2H2 type KRAB PF01352.25 T167693_2 - 3.5e-27 93.7 0.2 6.1e-27 92.9 0.2 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 T167693_2 - 9.2e-24 81.9 80.7 0.0027 18.3 0.7 11.4 11 0 0 11 11 11 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T167693_2 - 1.2e-18 66.5 61.8 0.00092 19.0 0.5 10.1 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T167693_2 - 2.2e-06 27.7 46.5 0.43 10.8 0.0 9.8 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 T167693_2 - 0.0014 18.2 46.0 0.067 12.8 0.3 8.7 9 0 0 9 9 9 4 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 T167693_2 - 0.0014 18.6 43.3 0.22 11.6 1.8 6.7 2 2 4 7 7 7 4 Zinc ribbon domain XPA_N PF01286.16 T167693_2 - 0.0033 17.3 30.6 2.8 7.9 0.4 8.9 8 0 0 8 8 8 2 XPA protein N-terminal zf-C2HE PF16278.3 T167693_2 - 0.014 15.7 0.3 0.014 15.7 0.3 8.5 4 4 3 8 8 8 0 C2HE / C2H2 / C2HC zinc-binding finger HypA PF01155.17 T167693_2 - 0.065 13.1 26.1 0.22 11.4 1.3 4.5 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 T167693_2 - 2.5 8.8 43.2 0.47 11.1 1.7 5.5 3 2 2 5 5 4 0 zinc-ribbon family C1_4 PF07975.10 T167693_2 - 8.9 6.5 40.2 1.5 9.0 1.4 5.7 2 1 1 5 5 5 0 TFIIH C1-like domain Sulfotransfer_1 PF00685.25 T136288_1 - 2e-20 73.2 0.0 2.8e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 T136288_1 - 4.5e-13 49.9 0.0 7.8e-12 45.9 0.0 2.4 1 1 0 1 1 1 1 Sulfotransferase family Oxysterol_BP PF01237.16 T232174_2 - 1.8e-130 434.9 0.2 2.4e-130 434.6 0.2 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 T232174_2 - 1.3e-14 54.4 0.1 2.5e-14 53.5 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 T232174_2 - 8.5e-12 45.1 0.1 1.5e-11 44.3 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 T232174_2 - 4.4e-05 23.7 2.1 0.0019 18.4 2.1 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.4 T232174_2 - 0.0033 17.5 0.0 0.0066 16.6 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Trypan_PARP PF05887.9 T232174_2 - 0.081 12.8 11.9 0.18 11.7 11.9 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) HeLo PF14479.4 T232174_2 - 0.31 10.7 1.3 0.42 10.3 0.6 1.5 1 1 0 1 1 1 0 Prion-inhibition and propagation V-set_2 PF15910.3 T206136_3 - 6.9e-59 196.7 1.1 1.2e-58 195.9 1.1 1.4 1 0 0 1 1 1 1 ICOS V-set domain ATG16 PF08614.9 T063519_1 - 9.1e-35 120.5 18.2 7.7e-18 65.3 17.1 2.3 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) WD40 PF00400.30 T063519_1 - 6.4e-21 74.2 12.4 7.6e-05 23.3 0.0 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 T063519_1 - 0.072 13.3 0.1 29 4.9 0.0 3.5 1 1 4 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain IncA PF04156.12 T063519_1 - 6.2 6.4 11.9 11 5.7 11.9 1.2 1 0 0 1 1 1 0 IncA protein Pkinase PF00069.23 T236267_1 - 4e-07 29.5 0.0 5.4e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Spc97_Spc98 PF04130.11 T236267_2 - 1.3e-92 311.2 0.0 6e-92 309.0 0.0 1.8 1 1 0 1 1 1 1 Spc97 / Spc98 family Hist_deacetyl PF00850.17 T236267_3 - 9.6e-79 264.9 0.0 2.1e-78 263.8 0.0 1.5 2 0 0 2 2 2 1 Histone deacetylase domain Pkinase PF00069.23 T236267_3 - 2.5e-50 171.2 0.0 3.5e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 T236267_3 - 7.8e-18 64.6 0.0 1.2e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 T236267_3 - 0.0027 17.5 0.0 0.0073 16.1 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.4 T236267_3 - 0.14 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Forkhead PF00250.16 T295813_3 - 3.3e-39 132.9 0.1 6.1e-39 132.1 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain 7tm_1 PF00001.19 T109753_1 - 3.9e-56 190.1 22.2 5.9e-56 189.5 22.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pro-rich PF15240.4 T074029_1 - 1.8e-06 28.3 72.3 1.8e-06 28.3 72.3 2.4 1 1 1 2 2 2 1 Proline-rich Pro-rich PF15240.4 T074029_3 - 3.5e-44 151.0 274.2 3e-31 108.9 63.7 3.1 1 1 3 4 4 4 4 Proline-rich Sulfotransfer_1 PF00685.25 T129486_1 - 8.6e-20 71.2 0.0 1.3e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 T129486_1 - 0.038 14.2 0.0 0.065 13.5 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase family Sulfotransfer_1 PF00685.25 T129486_3 - 4.6e-23 81.9 0.3 7e-23 81.3 0.3 1.2 1 0 0 1 1 1 1 Sulfotransferase domain zf-C4 PF00105.16 T238568_2 - 2.6e-31 107.8 16.3 6.6e-31 106.5 16.3 1.8 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 T238568_2 - 1.6e-22 80.0 0.2 2.5e-22 79.4 0.2 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Hormone_recep PF00104.28 T238568_3 - 5.7e-09 35.7 0.1 8.5e-09 35.1 0.1 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor 7tm_1 PF00001.19 T053398_1 - 0.0015 17.7 7.0 0.0015 17.7 7.0 3.4 2 2 1 3 3 3 1 7 transmembrane receptor (rhodopsin family) RNA_pol_Rpc4 PF05132.12 T053398_1 - 0.21 11.9 8.1 0.41 11.0 8.1 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 DDHD PF02862.15 T053398_1 - 0.59 10.1 4.9 0.89 9.5 4.9 1.2 1 0 0 1 1 1 0 DDHD domain Rtf2 PF04641.10 T053398_1 - 1.1 8.5 16.8 1.6 7.9 16.8 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger DUF1777 PF08648.10 T053398_2 - 1.1 9.3 45.8 1.8 8.6 45.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DUF1510 PF07423.9 T053398_2 - 2.9 7.1 23.2 4.6 6.5 23.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DDHD PF02862.15 T053398_2 - 5.5 6.9 9.8 8.3 6.3 9.8 1.1 1 0 0 1 1 1 0 DDHD domain RNA_pol_Rpc4 PF05132.12 T053398_3 - 0.25 11.6 8.2 0.61 10.4 8.2 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 Neur_chan_memb PF02932.14 T053398_3 - 6.5 6.6 5.5 11 5.9 5.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HLH PF00010.24 T364214_2 - 3.6e-15 55.5 0.3 7.3e-15 54.5 0.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain 3HCDH_N PF02737.16 T091000_3 - 2e-24 86.3 0.7 2.7e-13 50.1 0.0 2.1 1 1 1 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.20 T091000_3 - 5.1e-16 58.9 0.0 8e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 2-Hacid_dh_C PF02826.17 T091000_3 - 0.0027 16.9 0.0 0.0041 16.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.12 T091000_3 - 0.0072 15.8 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Ldh_1_N PF00056.21 T091000_3 - 0.057 13.4 0.0 0.091 12.7 0.0 1.2 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.19 T091000_3 - 0.069 12.3 0.0 0.099 11.8 0.0 1.1 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.14 T091000_3 - 0.1 12.1 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.21 T091000_3 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.13 T091000_3 - 0.15 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox_2 PF07992.12 T091000_3 - 0.23 10.5 0.0 0.33 10.0 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SRPRB PF09439.8 T330126_3 - 0.036 13.3 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Roc PF08477.11 T330126_3 - 0.044 13.9 0.0 0.54 10.4 0.0 2.1 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.7 T330126_3 - 0.11 12.1 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation 7tm_1 PF00001.19 T063645_2 - 1.3e-40 139.2 8.0 2e-40 138.6 8.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 T063645_2 - 0.015 14.6 0.1 0.024 13.8 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv Pkinase_Tyr PF07714.15 T340939_2 - 4.6e-93 311.1 0.0 7.1e-93 310.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.11 T340939_2 - 2.3e-52 176.3 1.9 4.2e-52 175.4 1.9 1.4 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.23 T340939_2 - 1.5e-42 145.7 0.0 2.6e-42 144.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 T340939_2 - 6.8e-12 45.7 1.4 2e-11 44.2 1.4 1.7 1 0 0 1 1 1 1 FERM central domain RHD_DNA_bind PF00554.20 T101844_1 - 3.1e-20 72.7 0.0 5.7e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 T101844_1 - 3.7e-19 68.5 0.0 6.3e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain TIG PF01833.22 T101844_1 - 2e-06 27.6 0.0 6e-06 26.1 0.0 1.9 1 0 0 1 1 1 1 IPT/TIG domain DUF3915 PF13054.4 T101844_3 - 4.5 7.1 5.6 8.2 6.3 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Troponin PF00992.18 T052959_3 - 1.1e-31 109.7 34.2 1.1e-31 109.7 34.2 2.1 1 1 1 2 2 2 2 Troponin Pkinase PF00069.23 T318086_3 - 4.2e-38 131.1 0.1 4.7e-30 104.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 T318086_3 - 6.4e-22 77.9 0.1 4.5e-19 68.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.12 T318086_3 - 0.084 12.1 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PKcGMP_CC PF16808.3 T318086_3 - 0.23 11.2 1.8 0.48 10.2 1.8 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase 7tm_4 PF13853.4 T211049_1 - 8.2e-48 163.4 21.9 1.2e-47 162.8 21.9 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T211049_1 - 2e-14 53.4 28.1 7.7e-14 51.4 28.1 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) HNH_2 PF13391.4 T211049_3 - 0.0056 16.7 0.2 0.025 14.6 0.1 2.0 2 0 0 2 2 2 1 HNH endonuclease LRR19-TM PF15176.4 T009385_1 - 5.9e-21 74.3 2.5 7e-19 67.7 2.5 2.2 1 1 0 1 1 1 1 Leucine-rich repeat family 19 TM domain CFC PF09443.8 T241663_1 - 1.1e-15 57.0 10.2 4.5e-15 55.1 10.2 2.2 1 0 0 1 1 1 1 Cripto_Frl-1_Cryptic (CFC) EGF_2 PF07974.11 T241663_1 - 1.9 8.8 16.0 0.067 13.4 7.8 2.7 2 0 0 2 2 2 0 EGF-like domain RasGEF PF00617.17 T288759_3 - 6.2e-51 172.9 0.4 1e-50 172.1 0.4 1.4 1 0 0 1 1 1 1 RasGEF domain PDZ PF00595.22 T288759_3 - 5.7e-14 52.1 0.1 1.3e-13 51.0 0.1 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RasGEF_N PF00618.18 T288759_3 - 6.5e-12 45.5 0.4 1.2e-10 41.4 0.4 2.6 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 T288759_3 - 2e-11 44.2 0.0 4e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain cNMP_binding PF00027.27 T288759_3 - 8e-11 41.7 0.0 4.6e-07 29.6 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_2 PF13180.4 T288759_3 - 0.0036 17.4 0.0 0.0093 16.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DUF4639 PF15479.4 T192049_1 - 0 1014.6 14.8 1.4e-302 1004.8 14.8 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4639) FMO-like PF00743.17 T025015_2 - 6.7e-44 150.1 0.0 8.9e-44 149.7 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like FMO-like PF00743.17 T025015_3 - 5.3e-150 500.2 0.2 4.1e-128 428.0 0.0 2.1 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 T025015_3 - 2.8e-11 43.1 0.0 4.7e-07 29.2 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 T025015_3 - 1.3e-05 25.2 0.0 2.5e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.17 T025015_3 - 0.00059 19.1 0.0 0.076 12.2 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K_oxygenase PF13434.4 T025015_3 - 0.0023 17.0 0.2 0.014 14.4 0.0 2.2 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.25 T025015_3 - 0.0026 18.1 0.2 0.23 11.9 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 T025015_3 - 0.0032 16.6 0.0 0.28 10.3 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase IlvN PF07991.10 T025015_3 - 0.035 13.5 0.0 0.12 11.8 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.18 T025015_3 - 0.073 13.0 0.0 0.77 9.7 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.22 T025015_3 - 0.095 12.2 0.0 0.56 9.6 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.19 T025015_3 - 0.11 11.6 0.1 0.42 9.7 0.0 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain tRNA-synt_1e PF01406.17 T099145_2 - 7e-104 347.3 2.4 3.8e-89 298.9 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.9 T099145_2 - 9.1e-13 47.6 0.1 2.2e-05 23.3 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.20 T099145_2 - 0.00097 17.4 0.0 0.0015 16.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.16 T099145_2 - 0.0013 17.6 0.3 0.0036 16.1 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (K) LRR_8 PF13855.4 T125144_1 - 3.2e-126 411.0 110.5 4.4e-16 58.3 0.1 9.8 1 1 13 14 14 14 14 Leucine rich repeat LRR_4 PF12799.5 T125144_1 - 9e-33 111.5 35.3 0.00049 20.3 0.0 11.2 7 2 5 12 12 12 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 T125144_1 - 2.1e-11 43.5 2.3 0.051 13.0 0.1 4.8 1 1 2 4 4 4 4 Leucine-rich repeat LRRNT PF01462.16 T125144_1 - 5.6e-09 35.3 1.5 5.6e-09 35.3 1.5 3.4 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 T125144_1 - 1.9e-05 24.3 50.4 19 6.1 0.3 17.0 16 3 0 16 16 16 2 Leucine Rich Repeat HAGH_C PF16123.3 T125144_2 - 1.3e-25 89.5 0.2 2.1e-25 88.9 0.2 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 T125144_2 - 1.1e-10 41.7 2.7 1.1e-06 28.6 0.9 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 T125144_2 - 0.014 14.8 0.4 0.032 13.6 0.4 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain zf-DHHC PF01529.18 T082745_1 - 1.2e-34 119.2 21.2 1.2e-34 119.2 21.2 2.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_4 PF13637.4 T082745_1 - 1.8e-21 76.1 4.6 4.5e-08 33.3 0.0 3.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.5 T082745_1 - 6.5e-21 74.6 0.0 3.4e-11 43.4 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T082745_1 - 2.6e-17 61.0 0.9 0.0045 17.3 0.0 5.9 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.4 T082745_1 - 3.5e-14 52.6 0.5 0.0034 17.6 0.0 4.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 T082745_1 - 3.4e-12 46.1 0.2 0.0069 16.7 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.28 T082745_2 - 8.1e-06 25.9 0.4 1.8e-05 24.9 0.4 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.4 T082745_2 - 7.3e-05 22.7 0.1 0.00018 21.5 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.5 T082745_2 - 0.0015 18.9 0.1 0.003 18.0 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T082745_2 - 0.0018 18.7 0.1 0.0038 17.7 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 T082745_2 - 0.017 15.4 0.2 0.036 14.3 0.2 1.4 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Sugar_tr PF00083.22 T138519_1 - 2.3e-12 46.4 14.7 1.6e-11 43.6 12.1 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.14 T138519_1 - 2.8e-09 36.2 49.2 4.6e-05 22.4 24.3 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-H2C2_2 PF13465.4 T054116_1 - 4.4e-67 219.6 94.5 8.5e-09 35.3 0.4 13.8 13 0 0 13 13 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 T054116_1 - 3.5e-55 181.4 93.1 1.1e-06 28.7 0.4 12.2 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T054116_1 - 7e-21 73.0 91.5 0.022 15.4 1.9 12.8 12 0 0 12 12 12 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T054116_1 - 3.6e-09 36.5 50.4 0.00059 19.8 2.0 7.4 6 1 2 8 8 8 7 Zinc ribbon domain zf-C2H2_jaz PF12171.6 T054116_1 - 8.4e-07 29.0 37.8 0.7 10.2 0.0 10.1 10 0 0 10 10 10 3 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 T054116_1 - 0.0048 16.8 37.0 2.6 8.0 0.3 9.7 9 0 0 9 9 9 2 XPA protein N-terminal FYDLN_acid PF09538.8 T054116_1 - 0.28 11.8 9.7 31 5.2 0.5 5.3 5 2 1 6 6 6 0 Protein of unknown function (FYDLN_acid) zf-C2H2_6 PF13912.4 T054116_1 - 2.2 8.2 60.8 0.64 9.9 0.9 10.2 10 0 0 10 10 10 0 C2H2-type zinc finger ADK_lid PF05191.12 T054116_1 - 6.1 6.8 49.4 0.16 11.9 1.9 7.0 6 2 1 7 7 7 0 Adenylate kinase, active site lid zf-RING_7 PF02591.13 T054116_1 - 8.7 6.5 18.7 11 6.2 0.1 6.4 6 0 0 6 6 6 0 C4-type zinc ribbon domain KRAB PF01352.25 T054116_2 - 1.5e-19 69.2 1.9 2.9e-19 68.3 1.9 1.4 1 0 0 1 1 1 1 KRAB box UPF0004 PF00919.18 T216394_2 - 2.5e-30 104.3 0.0 5.1e-30 103.3 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.19 T216394_2 - 6.7e-27 94.8 0.0 1.4e-26 93.7 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.18 T216394_2 - 3e-12 46.2 0.0 5.5e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 TRAM domain LRR_8 PF13855.4 T179265_1 - 4.3e-41 138.4 24.0 2.2e-14 52.8 2.5 4.8 2 2 1 4 4 4 4 Leucine rich repeat Josephin PF02099.15 T179265_1 - 5.2e-24 85.0 0.0 2.7e-23 82.7 0.0 2.0 1 1 0 1 1 1 1 Josephin DUF108 PF01958.16 T179265_1 - 5.2e-22 77.9 0.6 2.8e-21 75.5 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function DUF108 LRR_4 PF12799.5 T179265_1 - 4.8e-21 74.3 23.8 2.9e-05 24.2 0.2 5.9 2 1 4 7 7 7 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 T179265_1 - 8e-20 71.0 0.0 1.1e-12 47.9 0.0 2.2 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) I-set PF07679.14 T179265_1 - 3e-15 55.9 0.0 4.7e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 T179265_1 - 8.8e-12 45.3 0.2 1.9e-11 44.3 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 T179265_1 - 2.6e-09 37.0 0.7 4.8e-09 36.1 0.7 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.4 T179265_1 - 2.7e-09 36.6 4.8 4e-06 26.3 0.4 2.2 1 1 0 2 2 2 2 Leucine-rich repeat LRRNT PF01462.16 T179265_1 - 2.9e-05 23.5 3.1 0.00011 21.6 3.1 2.2 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain V-set PF07686.15 T179265_1 - 3.7e-05 23.7 1.5 0.0003 20.8 1.5 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 T179265_1 - 5.6e-05 23.3 0.4 0.00014 22.0 0.4 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 T179265_1 - 0.2 12.1 23.1 6.2 7.6 0.0 6.6 6 1 0 6 6 5 0 Leucine Rich Repeat WBP-1 PF11669.6 T294310_2 - 0.00019 21.9 5.2 0.0006 20.3 0.1 2.7 2 0 0 2 2 2 1 WW domain-binding protein 1 TIR PF01582.18 T195663_1 - 4.9e-45 153.3 0.0 7.7e-45 152.7 0.0 1.2 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 T195663_1 - 0.0028 17.8 0.0 0.0055 16.9 0.0 1.4 1 0 0 1 1 1 1 TIR domain Ig_2 PF13895.4 T195663_3 - 8.3e-11 41.9 4.2 8.2e-06 25.9 1.5 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 T195663_3 - 7.7e-08 32.7 4.6 0.0018 18.7 0.4 3.6 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 T195663_3 - 0.00089 19.3 3.4 5 7.2 1.3 3.6 3 1 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.3 T195663_3 - 0.001 19.2 1.1 0.0033 17.6 0.1 2.3 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain I-set PF07679.14 T195663_3 - 0.0059 16.5 0.5 2.2 8.3 0.1 3.3 3 0 0 3 3 3 1 Immunoglobulin I-set domain Pkinase PF00069.23 T195495_2 - 3e-61 207.0 0.0 4.4e-61 206.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.20 T195495_2 - 1.2e-57 195.6 0.0 1.9e-57 194.9 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 T195495_2 - 4.1e-44 150.7 0.0 6.1e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_6 PF13516.4 T304404_1 - 2.5e-17 61.2 18.9 7.3e-05 22.4 0.7 6.8 6 0 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.5 T304404_1 - 0.00046 20.4 14.4 0.12 12.7 1.3 4.3 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 T304404_1 - 5.8 6.6 15.4 14 5.4 5.6 4.4 3 1 1 4 4 4 0 Leucine rich repeat LRR_1 PF00560.31 T304404_1 - 7.9 7.3 8.0 4.2e+02 2.0 0.0 5.8 6 0 0 6 6 6 0 Leucine Rich Repeat tRNA-synt_2c PF01411.17 T304404_2 - 1.2e-173 578.5 0.0 1.5e-173 578.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.12 T304404_2 - 2.2e-08 33.9 0.0 5.5e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain C1_1 PF00130.20 T259167_1 - 1.8e-21 75.6 43.3 3.8e-10 39.3 4.4 4.0 3 0 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) RA PF00788.21 T259167_1 - 3.7e-20 72.2 0.0 1.3e-13 51.3 0.0 2.5 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain C1_2 PF03107.14 T259167_1 - 0.0026 17.9 24.6 0.13 12.4 2.0 4.0 3 0 0 3 3 3 2 C1 domain DAGK_acc PF00609.17 T259167_2 - 7e-49 166.1 0.0 9.4e-49 165.7 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 T259167_2 - 6.2e-23 80.7 0.0 1e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain CTNNB1_binding PF08347.9 T048809_3 - 4.3e-96 320.8 12.1 4.3e-96 320.8 12.1 2.4 2 1 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 T048809_3 - 1.8e-21 76.2 1.0 1.8e-21 76.2 1.0 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T048809_3 - 8.2e-08 32.6 2.0 1.8e-07 31.5 2.0 1.5 1 0 0 1 1 1 1 HMG-box domain PAS_3 PF08447.10 T177810_1 - 0.0058 16.8 0.0 0.0097 16.0 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.10 T177810_3 - 9.2e-05 22.5 0.0 0.0041 17.2 0.0 2.3 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.4 T177810_3 - 0.0018 18.2 0.0 0.012 15.6 0.1 2.0 2 0 0 2 2 2 1 PAS domain Peptidase_M28 PF04389.15 T058513_2 - 4.9e-16 58.9 0.0 7.1e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.13 T058513_2 - 8.3e-14 51.6 1.1 4.9e-11 42.7 0.1 2.3 1 1 1 2 2 2 2 Transferrin receptor-like dimerisation domain PA PF02225.20 T058513_2 - 3.5e-13 49.4 0.1 8.9e-13 48.0 0.0 1.7 2 0 0 2 2 2 1 PA domain Hist_deacetyl PF00850.17 T374476_2 - 3.6e-87 292.6 0.5 1.4e-86 290.6 0.0 2.1 3 0 0 3 3 3 1 Histone deacetylase domain zf-UBP PF02148.17 T374476_2 - 2e-16 59.9 12.8 2e-16 59.9 12.8 2.2 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein Hist_deacetyl PF00850.17 T374476_3 - 6.4e-76 255.6 0.0 9.5e-76 255.1 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Ras PF00071.20 T374476_3 - 6.7e-34 116.7 0.0 9.2e-34 116.2 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 T374476_3 - 5.2e-09 36.2 0.0 9.1e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF258 PF03193.14 T374476_3 - 1e-05 25.3 0.0 0.2 11.4 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Arf PF00025.19 T374476_3 - 0.0022 17.3 0.0 0.0036 16.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 T374476_3 - 0.02 14.9 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.4 T374476_3 - 0.07 12.6 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Neurexophilin PF06312.10 T067705_2 - 4.2e-19 68.7 0.0 7.3e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.17 T067705_2 - 0.07 13.8 0.0 0.51 11.0 0.0 2.1 2 0 0 2 2 2 0 Filamin/ABP280 repeat KRAP_IP3R_bind PF14722.4 T321264_1 - 3.7e-69 231.0 0.0 7.7e-69 230.0 0.0 1.6 1 0 0 1 1 1 1 Ki-ras-induced actin-interacting protein-IP3R-interacting domain SSFA2_C PF14723.4 T321264_1 - 1.5e-15 57.5 0.4 3.5e-15 56.2 0.4 1.7 1 0 0 1 1 1 1 Sperm-specific antigen 2 C-terminus DUF1640 PF07798.9 T321264_1 - 0.32 10.9 7.7 0.049 13.5 3.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Lectin_N PF03954.12 T321264_1 - 0.5 10.0 3.0 1.4 8.5 3.0 1.8 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain ANF_receptor PF01094.26 T291793_3 - 1.2e-69 234.9 0.0 1.7e-69 234.5 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 T291793_3 - 5.2e-59 198.2 0.1 9.1e-59 197.4 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 T291793_3 - 6.1e-44 148.7 0.0 1.2e-43 147.8 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 T291793_3 - 4.7e-23 81.6 0.0 8.7e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 T291793_3 - 0.11 12.1 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein DUF659 PF04937.13 T291793_3 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) HSL_N PF06350.10 T176290_2 - 3.1e-114 381.0 0.0 3.9e-114 380.6 0.0 1.1 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus Abhydrolase_3 PF07859.11 T176290_2 - 4.4e-46 157.3 0.1 4.5e-33 114.7 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.7 T176290_2 - 0.00019 20.3 0.0 0.0003 19.7 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase CXCL17 PF15211.4 T176290_3 - 2e-47 159.8 14.0 5.2e-47 158.4 14.0 1.8 1 0 0 1 1 1 1 VEGF co-regulated chemokine 1 PLAC8 PF04749.15 T176290_3 - 2.7e-14 53.8 10.3 9.8e-14 52.0 10.3 2.1 1 0 0 1 1 1 1 PLAC8 family FWWh PF14922.4 T116477_2 - 3.2e-48 163.3 5.5 5.6e-48 162.5 5.5 1.4 1 0 0 1 1 1 1 Protein of unknown function # # Program: hmmscan # Version: 3.1b2 (February 2015) # Pipeline mode: SCAN # Query file: /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/mitrans_coding/wd/mitrans_coding_5000.p.fa # Target file: /home/yduan/database/Pfam/Pfam-A.hmm # Option settings: hmmscan -o /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/mitrans_coding/hmmscan.outm --tblout /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/mitrans_coding/hmmscan.t.out /home/yduan/database/Pfam/Pfam-A.hmm /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/mitrans_coding/wd/mitrans_coding_5000.p.fa # Current dir: /home/yduan/work_file/lncRNAdb/methods_assement # Date: Sun Jul 1 19:38:51 2018 # [ok]