# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- VIR_N PF15912.3 T296733_3 - 0.19 11.3 0.5 0.38 10.3 0.5 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal Harakiri PF15196.4 T379040_1 - 1.3e-06 28.6 0.9 2.4e-06 27.8 0.9 1.4 1 0 0 1 1 1 1 Activator of apoptosis harakiri Harakiri PF15196.4 T379040_2 - 1.7e-05 25.0 9.5 3.4e-05 24.1 9.5 1.5 1 0 0 1 1 1 1 Activator of apoptosis harakiri HERV-K_env_2 PF13804.4 T202705_1 - 4.9e-37 127.2 0.2 7.6e-37 126.5 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GP41 PF00517.15 T202705_3 - 5.1e-10 39.4 0.3 8.7e-10 38.6 0.3 1.3 1 0 0 1 1 1 1 Retroviral envelope protein CCDC144C PF14915.4 T018815_1 - 4.9e-30 104.6 13.6 4.9e-30 104.6 13.6 4.3 4 0 0 4 4 4 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018815_1 - 0.0047 16.8 1.1 0.0047 16.8 1.1 3.1 4 0 0 4 4 4 1 Laminin Domain II CCDC144C PF14915.4 T018815_3 - 1.2e-29 103.3 16.4 1.2e-29 103.3 16.4 2.2 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018815_3 - 2.8e-16 59.7 6.5 2.8e-16 59.7 6.5 3.3 3 1 0 3 3 3 1 Domain of unknown function (DUF3496) dUTPase PF00692.17 T098465_2 - 4.3e-08 32.8 0.0 7.5e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 dUTPase Transposase_1 PF01359.16 T351101_2 - 0.045 13.5 0.1 0.094 12.5 0.1 1.4 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_1 PF01359.16 T351101_3 - 4.3e-21 74.4 7.1 1.4e-20 72.8 4.2 2.8 2 0 0 2 2 2 1 Transposase (partial DDE domain) BEN PF10523.7 T351101_3 - 0.058 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 BEN domain Mucin PF01456.15 T164576_3 - 3.1 7.7 7.3 4.8 7.0 7.3 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Toxin_16 PF07945.9 T353293_3 - 0.17 11.7 258.1 1.8 8.4 1.4 37.7 4 2 35 39 39 39 0 Janus-atracotoxin Transposase_1 PF01359.16 T271700_1 - 1.8e-21 75.6 0.4 4.5e-21 74.4 0.4 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) rve PF00665.24 T023857_1 - 1.8e-14 53.8 0.0 2.8e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain dUTPase PF00692.17 T023857_3 - 4.8e-14 52.0 0.0 7.4e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 dUTPase RNase_H PF00075.22 T377273_1 - 2.8e-07 30.7 0.0 1.1e-06 28.7 0.0 1.9 2 0 0 2 2 2 1 RNase H zf-H2C2 PF09337.8 T377273_2 - 1.3e-08 34.8 0.7 3e-08 33.6 0.7 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RVT_1 PF00078.25 T377273_2 - 2.7e-05 23.6 0.0 4e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T377273_3 - 7.6e-06 26.0 0.0 1.4e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain TMEM191C PF15194.4 T230009_2 - 4.6e-33 113.8 7.7 9.5e-33 112.7 7.7 1.5 1 0 0 1 1 1 1 TMEM191C family TMEM191C PF15194.4 T230009_3 - 3.1e-06 27.1 0.1 7.1e-06 26.0 0.1 1.5 1 0 0 1 1 1 1 TMEM191C family Pentapeptide PF00805.20 T138467_1 - 5.3e-05 22.6 1.0 0.29 10.7 0.1 5.0 5 0 0 5 5 5 2 Pentapeptide repeats (8 copies) Transposase_1 PF01359.16 T268994_1 - 5e-19 67.8 0.2 2.3e-18 65.7 0.0 2.2 2 0 0 2 2 2 1 Transposase (partial DDE domain) DUF4417 PF14386.4 T268994_1 - 0.027 13.9 0.1 0.048 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) DUF1725 PF08333.9 T268994_3 - 8.6e-07 28.3 0.7 1.8e-06 27.3 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) HTH_24 PF13412.4 T268994_3 - 0.16 11.4 0.0 0.32 10.5 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Transposase_22 PF02994.12 T269183_3 - 3.3e-152 506.5 18.8 5.3e-152 505.8 18.8 1.3 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T269183_3 - 3.2e-10 40.1 0.0 6e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T269183_3 - 1.4e-09 37.7 1.4 4.4e-09 36.1 1.4 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Atg14 PF10186.7 T269183_3 - 0.0009 18.3 8.3 0.0016 17.5 8.3 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spectrin PF00435.19 T269183_3 - 0.0087 16.4 6.8 0.025 14.9 6.8 1.8 1 0 0 1 1 1 1 Spectrin repeat EzrA PF06160.10 T269183_3 - 0.0087 14.2 9.5 0.014 13.5 9.5 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Seryl_tRNA_N PF02403.20 T269183_3 - 0.012 15.7 7.8 0.027 14.5 7.8 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.9 T269183_3 - 0.016 15.6 9.8 0.012 16.0 6.0 2.4 2 0 0 2 2 2 0 Syntaxin 6, N-terminal GAS PF13851.4 T269183_3 - 0.018 14.3 11.6 0.036 13.3 11.6 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Sec34 PF04136.13 T269183_3 - 0.021 14.6 4.3 0.048 13.4 4.3 1.6 1 0 0 1 1 1 0 Sec34-like family TPR_MLP1_2 PF07926.10 T269183_3 - 0.023 14.6 9.7 0.07 13.1 9.7 1.8 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein zf-C4H2 PF10146.7 T269183_3 - 0.025 14.8 10.0 0.049 13.8 10.0 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein DUF1664 PF07889.10 T269183_3 - 0.055 13.3 2.4 0.15 11.9 2.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) APG6 PF04111.10 T269183_3 - 0.069 12.4 12.1 0.14 11.4 12.1 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 T269183_3 - 0.11 12.2 10.7 0.2 11.3 10.7 1.4 1 0 0 1 1 1 0 IncA protein Mod_r PF07200.11 T269183_3 - 0.12 12.4 7.5 0.38 10.7 7.5 1.8 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein ZapB PF06005.10 T269183_3 - 0.13 12.6 7.4 0.46 10.8 7.4 1.9 1 0 0 1 1 1 0 Cell division protein ZapB KLRAQ PF10205.7 T269183_3 - 0.15 12.2 5.9 0.43 10.7 5.9 1.8 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein TBPIP PF07106.11 T269183_3 - 0.31 10.7 15.9 0.055 13.1 8.4 2.7 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF724 PF05266.12 T269183_3 - 0.46 10.2 8.5 0.87 9.2 8.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) LPP PF04728.11 T269183_3 - 0.51 10.6 1.6 0.74 10.1 0.2 2.0 2 0 0 2 2 1 0 Lipoprotein leucine-zipper Prominin PF05478.9 T269183_3 - 0.53 8.0 5.9 1.2 6.8 5.9 1.5 1 0 0 1 1 1 0 Prominin Mnd1 PF03962.13 T269183_3 - 0.62 9.8 10.1 1.4 8.6 10.1 1.6 1 0 0 1 1 1 0 Mnd1 family TMPIT PF07851.11 T269183_3 - 0.73 8.9 4.6 1.7 7.7 4.6 1.6 1 0 0 1 1 1 0 TMPIT-like protein DUF342 PF03961.11 T269183_3 - 0.87 8.0 7.7 1.5 7.2 7.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Laminin_II PF06009.10 T269183_3 - 1.1 9.1 3.4 3 7.7 3.4 1.6 1 0 0 1 1 1 0 Laminin Domain II Nup54 PF13874.4 T269183_3 - 1.1 9.2 6.3 2.7 7.9 6.3 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DUF2203 PF09969.7 T269183_3 - 1.2 9.7 4.1 2.7 8.6 3.3 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Jnk-SapK_ap_N PF09744.7 T269183_3 - 1.3 9.1 14.4 2.5 8.2 14.4 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Occludin_ELL PF07303.11 T269183_3 - 1.4 9.5 5.8 10 6.8 5.8 2.5 2 0 0 2 2 1 0 Occludin homology domain Spc24 PF08286.9 T269183_3 - 1.5 9.0 4.4 4.5 7.4 4.4 1.9 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Apolipoprotein PF01442.16 T269183_3 - 1.8 8.3 7.3 15 5.3 0.1 2.4 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF16 PF01519.14 T269183_3 - 2 8.8 6.8 11 6.5 6.8 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 PspA_IM30 PF04012.10 T269183_3 - 2.2 7.7 8.4 1.2 8.5 5.8 1.8 2 0 0 2 2 2 0 PspA/IM30 family Med2 PF11214.6 T269183_3 - 3.3 7.8 9.5 0.22 11.5 3.0 2.4 2 1 1 3 3 2 0 Mediator complex subunit 2 ATG16 PF08614.9 T269183_3 - 4.1 7.4 14.0 14 5.6 14.0 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) UPF0449 PF15136.4 T269183_3 - 9.2 6.7 7.0 23 5.4 5.9 2.1 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 RVP PF00077.18 T275256_1 - 0.00031 20.9 0.0 0.00059 19.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Gag_p30 PF02093.14 T275256_1 - 0.015 14.7 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein rve PF00665.24 T172345_1 - 0.14 12.3 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain RNase_H PF00075.22 T172345_2 - 9.5e-17 61.4 0.0 1.5e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 RNase H zf-H2C2 PF09337.8 T172345_2 - 3.6e-05 23.8 0.3 7.5e-05 22.8 0.3 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Transposase_22 PF02994.12 T266285_2 - 5.1e-95 318.3 20.5 2.9e-92 309.2 10.8 2.3 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T266285_2 - 5.3e-06 25.8 2.1 1.1e-05 24.9 2.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) HSBP1 PF06825.10 T266285_2 - 0.32 10.8 1.8 0.74 9.7 0.3 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 RVT_1 PF00078.25 T266285_3 - 6.7e-20 71.4 0.2 1.2e-19 70.6 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Dynein_heavy PF03028.13 T085622_3 - 5.9e-12 44.5 0.0 8.4e-12 44.0 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor CobT PF06213.10 T383688_2 - 0.2 10.9 29.6 0.26 10.5 29.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF1510 PF07423.9 T383688_2 - 0.51 9.6 32.1 0.67 9.2 32.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DDHD PF02862.15 T383688_2 - 1 9.3 10.0 1.3 8.9 10.0 1.1 1 0 0 1 1 1 0 DDHD domain RNA_pol_Rpc4 PF05132.12 T383688_2 - 3.3 8.0 13.2 4.6 7.5 13.2 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 FHIPEP PF00771.18 T383688_2 - 3.5 5.8 4.1 5.7 5.1 4.1 1.3 1 0 0 1 1 1 0 FHIPEP family RNA_pol_3_Rpc31 PF11705.6 T383688_2 - 4.3 7.3 29.0 6.5 6.8 29.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.10 T383688_2 - 4.5 5.2 30.8 5.5 4.9 30.8 1.0 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.10 T383688_2 - 5.2 6.7 26.5 7 6.3 26.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Transposase_1 PF01359.16 T246728_2 - 2.8e-14 52.6 0.1 7e-14 51.3 0.1 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) DUF4519 PF15012.4 T166066_3 - 0.087 12.9 0.1 0.087 12.9 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Ephrin_rec_like PF07699.11 T196649_1 - 0.66 9.6 10.0 0.59 9.8 5.7 2.4 1 1 1 2 2 2 0 Putative ephrin-receptor like TGF_beta PF00019.18 T282635_2 - 1.9e-08 35.0 2.2 3.4e-08 34.2 2.2 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain IQ_SEC7_PH PF16453.3 T314393_2 - 0.05 13.4 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 PH domain DUF1725 PF08333.9 T067412_3 - 0.0025 17.3 0.2 0.0054 16.2 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) COX17 PF05051.11 T316019_3 - 3.4 8.0 5.5 6.4 7.1 3.3 2.7 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) TLV_coat PF00429.17 T267284_1 - 1.6e-40 139.2 0.2 2.2e-40 138.7 0.2 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Gag_p30 PF02093.14 T267284_1 - 6.6e-19 68.1 0.0 1.1e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.18 T267284_1 - 0.025 14.3 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 gag gene protein p24 (core nucleocapsid protein) Gag_MA PF01140.17 T267284_1 - 0.074 12.6 0.3 0.14 11.7 0.3 1.4 1 0 0 1 1 1 0 Matrix protein (MA), p15 RVP PF00077.18 T267284_3 - 1.1e-05 25.5 0.0 1.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.21 T267284_3 - 0.41 10.7 6.4 0.045 13.7 1.0 2.4 2 0 0 2 2 2 0 Zinc knuckle dUTPase PF00692.17 T375501_1 - 6.9e-10 38.6 0.0 1e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 dUTPase rve PF00665.24 T375501_1 - 8.5e-06 25.8 0.0 1.4e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain BAR_3_WASP_bdg PF10456.7 T363336_1 - 1.1e-16 60.9 3.0 2e-08 33.9 1.1 2.2 2 0 0 2 2 2 2 WASP-binding domain of Sorting nexin protein BAR_3_WASP_bdg PF10456.7 T363336_3 - 6.7e-16 58.3 0.0 1.9e-14 53.6 0.0 2.0 2 0 0 2 2 2 2 WASP-binding domain of Sorting nexin protein Transposase_22 PF02994.12 T244050_1 - 3.8e-26 91.7 7.3 2.1e-16 59.6 4.8 2.2 2 0 0 2 2 2 2 L1 transposable element Transposase_22 PF02994.12 T244050_3 - 1.7e-92 310.0 25.4 1e-87 294.3 5.3 2.5 3 0 0 3 3 3 2 L1 transposable element Exo_endo_phos PF03372.21 T244050_3 - 3.2e-07 30.5 0.0 6.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Syntaxin-6_N PF09177.9 T244050_3 - 0.016 15.6 1.4 0.016 15.6 1.4 3.4 3 1 0 3 3 3 0 Syntaxin 6, N-terminal Seryl_tRNA_N PF02403.20 T244050_3 - 0.041 14.0 0.5 0.041 14.0 0.5 2.9 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ZapA PF05164.11 T244050_3 - 0.21 11.9 0.1 0.21 11.9 0.1 2.3 2 0 0 2 2 2 0 Cell division protein ZapA HSBP1 PF06825.10 T244050_3 - 1.6 8.6 7.1 1.3 8.9 0.2 3.3 3 0 0 3 3 3 0 Heat shock factor binding protein 1 BLOC1_2 PF10046.7 T244050_3 - 2.4 8.4 11.5 0.52 10.5 0.7 3.2 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.10 T244050_3 - 4.6 7.6 5.4 15 6.0 0.1 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.9 T244050_3 - 5.7 7.3 12.0 11 6.3 0.0 4.4 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.10 T244050_3 - 7.6 6.4 8.3 4.2 7.2 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) RVT_1 PF00078.25 T291135_1 - 1.1e-45 155.7 2.5 1.7e-45 155.1 2.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSBP1 PF06825.10 T291135_1 - 0.0018 18.0 3.1 0.0021 17.8 1.0 2.1 2 0 0 2 2 2 1 Heat shock factor binding protein 1 DUF4705 PF15788.3 T322062_1 - 6e-31 106.3 247.5 2.2e-14 53.2 12.6 22.5 7 5 10 17 17 17 9 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322062_2 - 1.6e-46 156.1 272.0 2.8e-18 65.7 10.8 22.2 10 6 9 20 20 20 16 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322062_3 - 1.6e-16 60.1 259.3 1.5e-06 28.1 6.1 22.1 17 5 3 20 20 20 13 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324656_1 - 5.3e-46 154.5 337.0 5.8e-18 64.7 10.4 28.0 20 10 8 28 28 28 16 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324656_2 - 2.9e-37 126.5 291.9 1.9e-14 53.5 9.4 27.5 17 8 7 24 24 24 15 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324656_3 - 2.4e-20 72.4 67.0 6.2e-14 51.8 9.7 28.9 19 9 9 28 28 28 11 Domain of unknown function (DUF4705) Transposase_22 PF02994.12 T240996_3 - 0.00017 20.5 2.3 0.00024 20.0 2.3 1.1 1 0 0 1 1 1 1 L1 transposable element DUF1317 PF07026.9 T257712_2 - 6.6e-05 22.5 35.8 67 3.3 0.1 14.6 12 3 3 15 15 15 1 Protein of unknown function (DUF1317) DUF3653 PF12375.6 T257712_2 - 0.029 14.3 0.3 15 5.6 0.0 4.0 4 0 0 4 4 4 0 Phage protein Histone_H2A_C PF16211.3 T316335_3 - 4.9e-08 32.4 50.6 0.18 11.5 0.2 11.6 2 1 8 12 12 12 10 C-terminus of histone H2A FF PF01846.17 T362447_1 - 1.8e-10 40.6 0.1 5.5e-07 29.5 0.0 2.4 2 0 0 2 2 2 2 FF domain Ribosomal_L39 PF00832.18 T003460_3 - 0.016 14.7 0.6 0.063 12.8 0.6 2.0 1 0 0 1 1 1 0 Ribosomal L39 protein Ectatomin PF06457.9 T337205_2 - 0.19 11.5 25.8 60 3.5 0.0 10.1 13 0 0 13 13 13 0 Ectatomin Ectatomin PF06457.9 T337205_3 - 0.036 13.8 32.6 57 3.6 0.0 12.9 15 0 0 15 15 15 0 Ectatomin RNase_H PF00075.22 T172330_2 - 3.4e-05 23.9 0.0 5.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 RNase H RNA_pol_Rpc4 PF05132.12 T344693_1 - 0.11 12.8 11.8 0.26 11.6 11.8 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.15 T344693_1 - 0.39 9.3 17.6 0.63 8.6 17.6 1.2 1 0 0 1 1 1 0 Presenilin MIP-T3 PF10243.7 T344693_1 - 0.99 7.9 54.7 1.3 7.5 54.7 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 SAPS PF04499.13 T344693_1 - 2.8 6.5 9.0 4 6.0 9.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DDHD PF02862.15 T344693_1 - 6.7 6.6 13.6 11 6.0 13.6 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.15 T344693_3 - 0.19 10.3 18.0 0.28 9.8 18.0 1.1 1 0 0 1 1 1 0 Presenilin rve PF00665.24 T310722_2 - 8.3e-08 32.3 0.0 1.7e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T310722_2 - 1.9e-07 31.1 0.1 4.4e-07 29.9 0.1 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.4 T310722_2 - 0.0047 16.5 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Plasmodium_HRP PF05403.9 T337784_2 - 0.36 10.4 29.6 0.54 9.9 29.6 1.2 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) HERV-K_env_2 PF13804.4 T167927_1 - 6.2e-22 78.0 0.3 9.7e-22 77.4 0.3 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein zf-CCHC_5 PF14787.4 T167927_1 - 6.2e-16 57.7 1.3 6.2e-16 57.7 1.3 2.0 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger GP41 PF00517.15 T167927_1 - 1e-11 44.9 3.6 1.6e-11 44.3 3.6 1.2 1 0 0 1 1 1 1 Retroviral envelope protein Gag_p24 PF00607.18 T167927_1 - 0.00031 20.6 0.0 0.00053 19.8 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) HERV-K_REC PF15695.3 T167927_1 - 0.00095 19.1 0.5 0.0017 18.2 0.5 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Gag_p24 PF00607.18 T167927_2 - 9.2e-29 100.6 0.0 5.3e-24 85.1 0.0 2.2 2 0 0 2 2 2 2 gag gene protein p24 (core nucleocapsid protein) HERV-K_env_2 PF13804.4 T167927_2 - 1.3e-08 34.7 0.0 2.2e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Gag_p10 PF02337.15 T167927_2 - 5.8e-06 25.9 0.1 1.2e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 Retroviral GAG p10 protein CytB6-F_Fe-S PF08802.8 T167927_2 - 7.2 6.6 5.4 41 4.2 3.2 2.4 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit Gag_p10 PF02337.15 T167927_3 - 0.0001 21.9 0.0 0.00019 21.1 0.0 1.3 1 0 0 1 1 1 1 Retroviral GAG p10 protein RVT_1 PF00078.25 T016083_2 - 8.7e-47 159.3 2.8 1.2e-46 158.9 2.8 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T016083_3 - 0.00023 20.6 0.1 0.00044 19.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) FlaC_arch PF05377.9 T330814_1 - 6.9e-05 23.0 47.1 0.41 10.9 0.9 9.0 3 3 4 8 8 8 5 Flagella accessory protein C (FlaC) HrpB7 PF09486.8 T330814_1 - 0.00064 20.0 22.6 1.1 9.4 0.2 5.9 3 3 3 6 6 6 3 Bacterial type III secretion protein (HrpB7) ERM PF00769.17 T330814_1 - 0.0012 18.6 46.6 0.004 16.9 12.0 3.6 3 1 0 3 3 3 3 Ezrin/radixin/moesin family Reo_sigmaC PF04582.10 T330814_1 - 0.0028 17.0 0.0 2.2 7.5 0.0 2.8 3 0 0 3 3 3 2 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.7 T330814_1 - 0.011 15.6 36.4 0.15 12.0 1.4 4.4 3 2 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.10 T330814_1 - 0.54 10.1 23.5 1.6 8.6 4.4 4.8 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.7 T330814_1 - 1.1 9.5 5.6 4.8 7.4 0.4 3.7 3 2 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fez1 PF06818.13 T330814_3 - 0.88 9.9 5.6 28 4.9 5.6 2.7 1 1 0 1 1 1 0 Fez1 RVT_1 PF00078.25 T239479_1 - 4.9e-52 176.5 1.8 1e-51 175.4 1.8 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.4 T239479_1 - 0.0028 17.2 0.3 0.0064 16.0 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4417) YlbE PF14003.4 T239479_1 - 0.19 12.1 8.8 0.39 11.1 0.0 3.4 3 0 0 3 3 3 0 YlbE-like protein Transposase_22 PF02994.12 T081234_1 - 2.4e-54 184.5 2.6 2.4e-54 184.5 2.6 2.0 2 0 0 2 2 2 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T081234_1 - 0.00015 21.4 0.0 0.0003 20.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF1725 PF08333.9 T081234_2 - 4.4e-06 26.1 0.1 1e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1725 PF08333.9 T324410_2 - 0.016 14.7 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) DUF2956 PF11169.6 T294566_2 - 0.44 10.6 9.4 1.1 9.3 9.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) DUF4366 PF14283.4 T294566_3 - 0.64 9.3 1.4 1 8.7 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Transposase_22 PF02994.12 T187876_1 - 1.7e-72 244.2 10.1 1.7e-46 158.6 0.2 3.3 3 0 0 3 3 3 3 L1 transposable element DUF1725 PF08333.9 T187876_1 - 1.5e-06 27.5 0.7 3.3e-06 26.5 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos PF03372.21 T187876_2 - 1.7e-09 37.8 0.0 2.8e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T187876_2 - 1.7e-07 31.0 1.6 3.2e-07 30.1 1.6 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase FadA PF09403.8 T187876_2 - 6.6 7.1 10.2 1.6 9.1 0.2 2.8 2 0 0 2 2 2 0 Adhesion protein FadA RVT_1 PF00078.25 T187876_3 - 8.3e-48 162.7 1.2 1.3e-47 162.1 1.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T187876_3 - 5.4e-38 130.7 3.2 8.4e-38 130.0 3.2 1.3 1 0 0 1 1 1 1 L1 transposable element Transposase_1 PF01359.16 T351126_2 - 0.027 14.2 0.1 0.082 12.7 0.1 1.7 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_1 PF01359.16 T351126_3 - 5.8e-21 74.0 7.5 1.6e-20 72.6 4.6 2.6 2 0 0 2 2 2 1 Transposase (partial DDE domain) DDE_3 PF13358.4 T351126_3 - 0.003 17.2 0.4 0.0053 16.4 0.4 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BEN PF10523.7 T351126_3 - 0.062 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 BEN domain Thymosin PF01290.18 T060409_1 - 1.8e-12 46.6 7.0 3e-12 45.9 7.0 1.3 1 0 0 1 1 1 1 Thymosin beta-4 family RVT_1 PF00078.25 T227039_1 - 7.1e-15 55.0 0.2 1.2e-14 54.2 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T227039_3 - 3e-25 88.7 4.6 3.1e-20 72.2 2.3 2.2 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T227039_3 - 2e-06 27.3 0.3 2e-06 27.3 0.3 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T379585_1 - 0.019 14.3 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein RVT_1 PF00078.25 T379585_2 - 1.4e-36 126.0 1.6 2.6e-34 118.6 1.8 2.2 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.18 T379585_2 - 1.9e-06 27.9 0.0 3.5e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T379585_2 - 0.015 15.4 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain zf-CCHC PF00098.21 T379585_3 - 1.9 8.6 11.9 0.68 10.0 6.3 2.7 2 0 0 2 2 2 0 Zinc knuckle Ephrin_rec_like PF07699.11 T196596_1 - 0.47 10.1 4.8 0.12 12.0 0.6 2.1 1 1 1 2 2 2 0 Putative ephrin-receptor like DUF1647 PF07801.9 T165122_2 - 0.95 9.2 9.1 53 3.5 0.1 5.0 1 1 1 5 5 5 0 Protein of unknown function (DUF1647) PELOTA_1 PF15608.4 T165122_2 - 5.6 6.8 45.9 2.5 7.9 0.4 10.4 1 1 11 12 12 12 0 PELOTA RNA binding domain Transposase_1 PF01359.16 T076802_2 - 3.6e-18 65.1 0.0 7.8e-18 64.0 0.0 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) TLV_coat PF00429.17 T171326_1 - 6.6e-99 332.0 3.5 8.8e-99 331.6 3.5 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RNase_H PF00075.22 T171326_3 - 0.018 15.1 0.0 0.029 14.4 0.0 1.2 1 0 0 1 1 1 0 RNase H DUF4349 PF14257.4 T136065_2 - 1.2 8.4 3.8 1.8 7.9 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF2722 PF10846.6 T136065_3 - 0.00044 19.2 10.1 0.00065 18.6 10.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.11 T136065_3 - 0.039 13.8 13.4 0.059 13.2 13.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Shugoshin_C PF07557.9 T051498_2 - 0.16 11.7 1.7 87 2.9 0.1 3.7 3 0 0 3 3 3 0 Shugoshin C terminus DUF3665 PF12427.6 T051498_3 - 1.4 8.6 6.2 88 2.8 0.0 4.3 4 0 0 4 4 4 0 Branched-chain amino acid aminotransferase Gag_p30 PF02093.14 T190484_1 - 0.048 13.0 0.0 0.076 12.4 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein RVP PF00077.18 T190484_2 - 0.00013 22.0 0.0 0.00031 20.8 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease 7kD_coat PF02495.15 T315742_3 - 0.13 11.8 0.1 8.6 6.0 0.0 2.2 1 1 1 2 2 2 0 7kD viral coat protein RNA_pol_Rpc4 PF05132.12 T356545_1 - 0.053 13.8 2.6 0.093 13.0 2.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Pentapeptide_4 PF13599.4 T193720_1 - 7.1e-05 22.7 0.0 0.18 11.8 0.0 3.0 2 1 0 2 2 2 2 Pentapeptide repeats (9 copies) Lamprin PF06403.9 T193720_1 - 0.11 12.4 0.0 8.9 6.1 0.0 2.2 2 1 1 3 3 3 0 Lamprin DUF2924 PF11149.6 T193720_1 - 7.8 6.7 10.2 6.4 7.0 0.7 3.9 2 2 1 3 3 3 0 Protein of unknown function (DUF2924) Pentapeptide_4 PF13599.4 T193720_2 - 0.0093 15.9 0.0 6.1 6.9 0.0 2.7 3 0 0 3 3 3 2 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T193720_3 - 8.9e-07 28.8 0.1 0.015 15.3 0.1 3.5 2 2 1 3 3 3 3 Pentapeptide repeats (9 copies) DUF2924 PF11149.6 T193720_3 - 2.2 8.5 7.7 0.6 10.3 2.0 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF2924) Epiglycanin_C PF14654.4 T300746_1 - 4.1e-09 36.3 0.7 8.7e-09 35.2 0.7 1.5 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300746_1 - 2.6e-06 27.3 4.4 6e-06 26.1 4.4 1.6 1 0 0 1 1 1 1 Mucin-like Mucin-like PF16058.3 T300746_3 - 0.026 14.5 5.9 0.056 13.4 5.9 1.6 1 0 0 1 1 1 0 Mucin-like Herpes_LMP1 PF05297.9 T300746_3 - 8.1 5.4 8.3 12 4.8 8.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Wbp11 PF09429.8 T093956_1 - 0.086 13.1 8.7 0.18 12.1 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 Gag_p10 PF02337.15 T090543_1 - 2.7e-27 94.3 0.2 5.1e-27 93.4 0.2 1.4 1 0 0 1 1 1 1 Retroviral GAG p10 protein RVT_1 PF00078.25 T090543_2 - 2e-31 109.1 0.0 3.1e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HERV-K_REC PF15695.3 T090543_2 - 1.2e-09 37.9 1.6 2.8e-09 36.8 1.6 1.5 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 HERV-K_env_2 PF13804.4 T090543_3 - 3.2e-87 290.4 1.7 5.3e-87 289.7 1.7 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_REC PF15695.3 T090543_3 - 1.9e-15 56.5 1.1 3.4e-15 55.7 1.1 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 RVT_1 PF00078.25 T090543_3 - 0.00012 21.6 0.2 0.0002 20.8 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GP41 PF00517.15 T090543_3 - 0.00081 19.2 0.1 0.0015 18.3 0.1 1.3 1 0 0 1 1 1 1 Retroviral envelope protein Trypsin PF00089.24 T338761_3 - 6.8e-26 91.3 0.3 1.1e-25 90.6 0.3 1.3 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 T338761_3 - 2.2e-10 40.8 0.7 4.1e-10 39.9 0.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Cep57_CLD_2 PF14197.4 T081051_1 - 0.098 12.6 0.8 0.18 11.7 0.8 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 RVT_1 PF00078.25 T081051_2 - 9.5e-15 54.6 0.0 1.8e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T081051_3 - 1.2e-18 67.3 0.6 1.8e-18 66.7 0.6 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T373887_3 - 1.3e-38 132.6 4.1 2.2e-38 131.9 4.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CCDC144C PF14915.4 T018783_1 - 2.2e-64 217.4 37.8 4.1e-36 124.5 14.1 2.2 2 0 0 2 2 2 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018783_1 - 0.007 16.3 1.1 0.007 16.3 1.1 1.9 2 0 0 2 2 2 1 Laminin Domain II CCDC144C PF14915.4 T018783_2 - 6.6e-17 61.5 9.6 6.6e-17 61.5 9.6 1.6 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region zf-CCHC_5 PF14787.4 T336585_1 - 1.9e-14 52.9 1.0 4.3e-14 51.8 1.0 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger rve PF00665.24 T336585_1 - 4.1e-08 33.3 0.0 6.8e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain IN_DBD_C PF00552.19 T336585_1 - 1.4e-07 30.5 2.6 1.4e-07 30.5 2.6 1.8 2 0 0 2 2 2 1 Integrase DNA binding domain HERV-K_REC PF15695.3 T336585_1 - 0.0025 17.7 0.3 0.006 16.5 0.3 1.6 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Gag_p24 PF00607.18 T336585_2 - 6.8e-40 137.0 0.0 9.4e-40 136.5 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) Integrase_Zn PF02022.17 T336585_2 - 3.4e-14 52.4 2.3 9.7e-14 50.9 2.3 1.9 1 0 0 1 1 1 1 Integrase Zinc binding domain RNase_H PF00075.22 T336585_2 - 1.2e-12 48.1 0.0 1.9e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T336585_2 - 2.1e-07 30.6 0.0 3.4e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T336585_2 - 0.00013 22.0 0.0 0.00025 21.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.21 T336585_2 - 0.0034 17.2 6.2 0.0034 17.2 6.2 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.4 T336585_2 - 0.081 12.5 2.5 0.17 11.5 2.5 1.5 1 0 0 1 1 1 0 Zinc knuckle RVP PF00077.18 T336585_3 - 1.3e-24 86.3 0.1 2.6e-24 85.3 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease dUTPase PF00692.17 T336585_3 - 7.9e-20 70.7 0.0 1.2e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 dUTPase G-patch PF01585.21 T336585_3 - 9.1e-08 31.8 1.1 2.6e-07 30.3 1.1 1.8 1 0 0 1 1 1 1 G-patch domain HERV-K_env_2 PF13804.4 T336585_3 - 2.8e-05 23.8 0.1 4.6e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein gag-asp_proteas PF13975.4 T336585_3 - 0.069 13.6 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Rifin_STEVOR PF02009.14 T381762_2 - 6.7 6.4 8.0 9.1 5.9 8.0 1.1 1 0 0 1 1 1 0 Rifin/stevor family VCX_VCY PF15231.4 T381762_3 - 1.2e-05 25.9 0.1 2.3e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Variable charge X/Y family RVT_1 PF00078.25 T119708_1 - 2.5e-40 138.2 0.5 5.2e-40 137.2 0.5 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T119708_2 - 3.4e-110 368.2 20.2 4.2e-109 364.6 20.2 2.0 1 1 0 1 1 1 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T119708_2 - 6.2e-05 22.7 0.5 0.00011 21.9 0.5 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T119708_2 - 0.026 14.6 0.0 0.054 13.6 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF1725 PF08333.9 T324409_3 - 0.0094 15.5 0.0 0.019 14.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) ubiquitin PF00240.21 T166767_1 - 0.00053 19.5 0.0 0.00083 18.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family ArgoL1 PF08699.8 T124793_3 - 0.064 12.8 0.7 0.16 11.5 0.7 1.6 1 0 0 1 1 1 0 Argonaute linker 1 domain Yae1_N PF09811.7 T229453_2 - 0.88 9.2 7.0 1.9 8.1 7.0 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal DUF4705 PF15788.3 T323241_1 - 0.056 13.5 22.0 1.6 8.8 8.4 3.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323241_2 - 0.00023 21.2 6.4 0.00023 21.2 6.4 6.4 6 1 1 7 7 7 2 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323241_3 - 0.0062 16.6 4.8 0.0062 16.6 4.8 5.8 5 1 0 5 5 5 2 Domain of unknown function (DUF4705) RNase_H PF00075.22 T280394_1 - 1.1e-12 48.2 0.0 2.1e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 RNase H zf-CCHC PF00098.21 T280394_1 - 0.00033 20.4 1.8 0.0014 18.4 1.8 2.2 1 0 0 1 1 1 1 Zinc knuckle TLV_coat PF00429.17 T280394_3 - 2.8e-19 69.1 0.4 4.5e-19 68.4 0.4 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Gag_p30 PF02093.14 T280394_3 - 1.9e-12 47.0 0.0 3.3e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T280394_3 - 5.2e-10 39.1 0.0 8e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.18 T280394_3 - 2.7e-05 24.3 0.0 5.7e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Gag_p24 PF00607.18 T280394_3 - 0.12 12.1 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 gag gene protein p24 (core nucleocapsid protein) Arylesterase PF01731.18 T381519_1 - 0.032 14.3 0.0 0.054 13.6 0.0 1.3 1 0 0 1 1 1 0 Arylesterase Gag_p30 PF02093.14 T159802_1 - 0.0061 16.0 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T159802_1 - 0.08 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC PF00098.21 T159802_3 - 1.6e-05 24.6 3.9 4.4e-05 23.2 3.9 1.8 1 0 0 1 1 1 1 Zinc knuckle RVT_1 PF00078.25 T159802_3 - 0.12 11.8 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T226502_1 - 1.3e-12 47.6 0.0 1.8e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein DUF2116 PF09889.7 T291743_2 - 0.0083 16.0 0.2 0.033 14.0 0.2 2.1 1 0 0 1 1 1 1 Uncharacterized protein containing a Zn-ribbon (DUF2116) Antimicrobial_9 PF08104.9 T090910_3 - 0.34 10.8 2.7 0.24 11.3 0.2 2.0 2 0 0 2 2 2 0 Ponericin L family VCX_VCY PF15231.4 T381756_2 - 1.7e-06 28.6 0.1 2.4e-06 28.1 0.1 1.2 1 0 0 1 1 1 1 Variable charge X/Y family Ectatomin PF06457.9 T337206_1 - 0.18 11.6 25.8 60 3.5 0.0 10.1 13 0 0 13 13 13 0 Ectatomin Ectatomin PF06457.9 T337206_2 - 0.034 13.9 32.6 57 3.6 0.0 12.9 15 0 0 15 15 15 0 Ectatomin Serpin PF00079.18 T295983_1 - 2.7e-05 23.6 0.0 3.8e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF2161 PF09929.7 T295983_2 - 1.4 8.9 5.1 60 3.7 0.0 4.2 5 0 0 5 5 5 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) RVT_1 PF00078.25 T344941_2 - 4.7e-15 55.6 0.0 6.2e-14 51.9 0.0 2.1 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T344941_2 - 2.4e-08 34.1 0.2 4.1e-08 33.3 0.2 1.4 1 0 0 1 1 1 1 Integrase core domain Gag_MA PF01140.17 T344941_2 - 0.0014 18.2 0.3 0.0026 17.3 0.3 1.3 1 0 0 1 1 1 1 Matrix protein (MA), p15 RNase_H PF00075.22 T344941_2 - 0.055 13.5 1.1 0.1 12.7 1.1 1.3 1 0 0 1 1 1 0 RNase H Gag_p30 PF02093.14 T344941_3 - 6.4e-20 71.4 0.1 9.9e-20 70.8 0.1 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein GP41 PF00517.15 T202697_2 - 4e-10 39.7 0.3 6.8e-10 39.0 0.3 1.3 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_env_2 PF13804.4 T202697_3 - 3.8e-37 127.5 0.2 5.9e-37 126.9 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein TLV_coat PF00429.17 T370873_1 - 6.6e-07 28.2 0.5 3.2e-06 26.0 0.5 1.8 1 1 0 1 1 1 1 ENV polyprotein (coat polyprotein) FTHFS PF01268.17 T359282_1 - 1e-28 99.8 0.0 1.3e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase Ank_3 PF13606.4 T174062_2 - 0.045 14.2 0.0 0.54 10.9 0.0 2.7 3 0 0 3 3 3 0 Ankyrin repeat SSP160 PF06933.9 T238527_1 - 0.15 10.1 9.5 0.21 9.6 9.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.6 T238527_1 - 8.9 6.2 16.0 23 4.8 16.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Suf PF05843.12 T238527_2 - 0.021 14.7 2.3 0.032 14.1 2.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CCDC117 PF15810.3 T238527_2 - 0.26 11.5 3.2 3.2 7.9 1.3 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 117 DUF2722 PF10846.6 T238527_2 - 1.1 8.0 6.7 1.6 7.5 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.6 T238527_2 - 1.3 8.4 11.0 2.7 7.4 11.0 1.4 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.3 T238527_2 - 6.7 6.8 13.9 0.23 11.4 7.5 1.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 RVT_1 PF00078.25 T291134_3 - 8.2e-46 156.2 2.5 1.3e-45 155.5 2.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSBP1 PF06825.10 T291134_3 - 0.0008 19.2 1.0 0.0017 18.1 1.0 1.6 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Transposase_22 PF02994.12 T346737_1 - 5.3e-64 216.2 8.9 2e-57 194.6 5.4 2.2 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T346737_2 - 3.8e-35 121.3 1.9 6.7e-35 120.5 1.9 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T346737_2 - 5.1e-14 51.8 14.6 2.7e-07 29.7 2.9 2.2 2 0 0 2 2 2 2 L1 transposable element HSBP1 PF06825.10 T346737_2 - 0.026 14.3 0.1 0.06 13.2 0.1 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 DUF3704 PF12488.6 T100040_1 - 0.084 12.4 0.1 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) IncA PF04156.12 T215542_1 - 3.1 7.4 8.7 6.5 6.4 8.7 1.5 1 0 0 1 1 1 0 IncA protein Transposase_22 PF02994.12 T215542_2 - 2.9e-117 391.5 11.5 5.2e-117 390.7 11.5 1.4 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T215542_2 - 4e-42 144.1 1.2 6.9e-42 143.3 1.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T215542_2 - 0.00047 20.3 0.1 0.002 18.2 0.0 1.9 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DUF1725 PF08333.9 T215542_3 - 7.2e-07 28.6 0.9 1.7e-06 27.4 0.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Pentapeptide_4 PF13599.4 T358920_2 - 9.7e-13 47.9 5.4 8.2e-06 25.7 2.2 3.3 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) V-set PF07686.15 T248985_2 - 2.4e-07 30.7 0.1 1.6e-06 28.1 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 T248985_2 - 0.0066 16.4 1.4 0.091 12.7 0.0 3.0 3 1 0 3 3 3 1 Immunoglobulin I-set domain ig PF00047.23 T248985_2 - 0.011 15.7 1.2 0.18 11.9 0.1 2.7 2 1 0 2 2 2 0 Immunoglobulin domain DUF3704 PF12488.6 T248985_3 - 0.13 11.8 1.4 0.35 10.4 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) Transposase_1 PF01359.16 T218619_1 - 2.5e-18 65.6 0.1 8.5e-18 63.9 0.0 1.9 2 0 0 2 2 2 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T218619_2 - 0.016 14.9 1.1 0.028 14.1 1.1 1.3 1 0 0 1 1 1 0 Transposase (partial DDE domain) Neural_ProG_Cyt PF06567.9 T099094_1 - 7.2 6.7 19.7 2.5e+02 1.8 0.1 8.7 1 1 3 4 4 4 0 Neural chondroitin sulphate proteoglycan cytoplasmic domain Sfi1 PF08457.8 T099094_2 - 9e-06 24.4 63.9 0.0016 16.9 21.3 3.0 1 1 2 3 3 3 3 Sfi1 spindle body protein CK1gamma_C PF12605.6 T099094_2 - 0.23 12.5 3.8 0.88 10.7 3.8 2.0 1 0 0 1 1 1 0 Casein kinase 1 gamma C terminal DDE_1 PF03184.17 T045962_1 - 6.6e-18 64.8 0.0 1.7e-17 63.4 0.0 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 T045962_1 - 9.5e-09 35.0 0.0 1.8e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.11 T045962_2 - 0.00015 21.1 0.2 0.00033 20.1 0.2 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DDE_1 PF03184.17 T045962_2 - 0.0028 17.1 1.1 0.0069 15.9 0.2 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF4573 PF15140.4 T052830_1 - 0.19 11.4 6.8 0.43 10.2 6.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4573) PRCC PF10253.7 T362735_3 - 4.1 8.0 4.2 6.2 7.4 4.2 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Orn_DAP_Arg_deC PF00278.20 T007028_1 - 4.3e-11 42.8 0.0 7.3e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DUF1725 PF08333.9 T007028_2 - 0.14 11.7 0.3 0.28 10.8 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Orn_Arg_deC_N PF02784.14 T007028_3 - 7.4e-06 25.5 0.0 1.1e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain CCDC144C PF14915.4 T018830_1 - 2.8e-29 102.1 13.6 2.8e-29 102.1 13.6 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region BAR_3_WASP_bdg PF10456.7 T018830_1 - 9e-13 48.1 0.1 9e-13 48.1 0.1 2.8 3 0 0 3 3 3 1 WASP-binding domain of Sorting nexin protein Laminin_II PF06009.10 T018830_1 - 1.8 8.4 15.1 0.026 14.4 1.1 2.5 2 0 0 2 2 2 0 Laminin Domain II BAR_3_WASP_bdg PF10456.7 T018830_2 - 4.3e-16 59.0 1.1 2e-08 33.9 0.4 2.1 2 0 0 2 2 2 2 WASP-binding domain of Sorting nexin protein CCDC144C PF14915.4 T018830_2 - 6.7e-07 28.6 3.0 9.2e-07 28.1 3.0 1.2 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region CCDC144C PF14915.4 T018830_3 - 6.6e-29 100.9 16.4 6.6e-29 100.9 16.4 2.0 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region GATase_7 PF13537.4 T222968_3 - 2.8e-10 40.0 0.0 5.5e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.4 T222968_3 - 6.5e-06 26.2 0.0 1.1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.6 T222968_3 - 0.1 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Aluminium induced protein TGF_beta PF00019.18 T282641_3 - 3.6e-08 34.1 2.2 6.3e-08 33.3 2.2 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain CCDC144C PF14915.4 T018769_1 - 1.3e-16 60.4 9.6 2.5e-16 59.6 9.6 1.3 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region BAR_3_WASP_bdg PF10456.7 T018769_1 - 9.9e-09 34.9 0.3 1.8e-08 34.0 0.3 1.3 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein CCDC144C PF14915.4 T018769_3 - 1.5e-59 201.5 37.8 1.6e-35 122.6 14.1 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018769_3 - 4.3e-07 30.1 8.4 4.3e-07 30.1 8.4 4.0 3 1 1 4 4 4 1 Domain of unknown function (DUF3496) Laminin_II PF06009.10 T018769_3 - 1.4 8.8 13.2 0.026 14.4 1.1 2.5 2 0 0 2 2 2 0 Laminin Domain II DUF4766 PF15973.3 T251177_2 - 5.2 7.5 26.5 0.39 11.2 6.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4766) Transposase_22 PF02994.12 T160445_1 - 5.1e-42 143.9 28.5 4.2e-36 124.5 10.9 3.1 3 0 0 3 3 3 3 L1 transposable element Transposase_22 PF02994.12 T160445_2 - 3.7e-19 68.7 0.2 5.9e-19 68.0 0.2 1.3 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T160445_2 - 6.7e-12 45.3 0.9 2.1e-07 30.5 0.5 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1943 PF09172.9 T325743_3 - 0.4 9.8 18.1 0.41 9.7 1.5 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF1943) LBP_BPI_CETP PF01273.23 T325743_3 - 0.42 10.1 3.6 1.8 8.0 0.1 2.8 2 1 0 2 2 2 0 LBP / BPI / CETP family, N-terminal domain PTPRCAP PF15713.3 T008087_2 - 0.046 13.9 34.5 0.064 13.4 34.5 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.12 T008087_2 - 0.13 10.4 24.8 0.16 10.1 24.8 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.10 T008087_2 - 0.5 9.6 35.3 0.72 9.1 35.3 1.2 1 0 0 1 1 1 0 SDA1 DDHD PF02862.15 T008087_2 - 2.1 8.3 8.2 3.4 7.6 8.2 1.3 1 0 0 1 1 1 0 DDHD domain Nop14 PF04147.10 T008087_2 - 3.7 5.5 40.6 4.6 5.2 40.6 1.0 1 0 0 1 1 1 0 Nop14-like family Mpp10 PF04006.10 T008087_2 - 4.9 5.4 39.2 6.3 5.0 39.2 1.1 1 0 0 1 1 1 0 Mpp10 protein DUF913 PF06025.10 T008087_2 - 5.8 5.6 12.4 7.2 5.3 12.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RNA_pol_Rpc4 PF05132.12 T008087_3 - 0.02 15.2 16.6 0.03 14.6 16.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DDHD PF02862.15 T008087_3 - 0.025 14.6 10.9 0.029 14.4 10.9 1.1 1 0 0 1 1 1 0 DDHD domain NPR3 PF03666.11 T008087_3 - 0.029 13.0 26.7 0.037 12.7 26.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RP-C_C PF11800.6 T008087_3 - 0.036 14.0 7.2 0.044 13.7 7.2 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4228 PF14009.4 T008087_3 - 0.061 13.6 9.4 0.079 13.3 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Otopetrin PF03189.11 T008087_3 - 0.066 11.9 2.6 0.069 11.8 2.6 1.1 1 0 0 1 1 1 0 Otopetrin Zip PF02535.20 T008087_3 - 0.32 10.0 12.7 0.38 9.8 12.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.15 T008087_3 - 0.89 8.1 19.0 1.2 7.7 19.0 1.1 1 0 0 1 1 1 0 Presenilin AAA_11 PF13086.4 T008087_3 - 1.2 8.7 23.4 1.5 8.3 23.4 1.1 1 0 0 1 1 1 0 AAA domain SLC12 PF03522.13 T008087_3 - 1.3 7.8 20.6 1.6 7.5 20.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 VID27 PF08553.8 T008087_3 - 2.6 6.3 21.8 3.4 6.0 21.8 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein Ndc1_Nup PF09531.8 T008087_3 - 4.4 5.7 8.5 4.6 5.7 8.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SpoIIP PF07454.9 T008087_3 - 6.2 6.1 22.5 8.3 5.6 22.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.6 T008087_3 - 7.6 5.1 24.4 10 4.6 24.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2126 PF09899.7 T008087_3 - 8.1 4.3 10.0 9.6 4.0 10.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF1510 PF07423.9 T008087_3 - 9 5.5 29.3 12 5.1 29.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RPOL_N PF14700.4 T008087_3 - 9.9 5.3 26.1 14 4.8 26.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal DUF1725 PF08333.9 T253759_3 - 8.4e-08 31.5 0.1 1.6e-07 30.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Ectatomin PF06457.9 T337204_1 - 0.21 11.4 25.8 61 3.5 0.0 10.1 13 0 0 13 13 13 0 Ectatomin Ectatomin PF06457.9 T337204_2 - 0.045 13.5 32.7 57 3.6 0.0 12.9 15 0 0 15 15 15 0 Ectatomin RVT_1 PF00078.25 T377436_2 - 2.1e-43 148.3 1.2 2.1e-43 148.3 1.2 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T377436_3 - 3.8e-122 407.5 22.1 5.1e-108 361.1 10.2 2.2 2 0 0 2 2 2 2 L1 transposable element Ank_2 PF12796.5 T040995_2 - 0.0002 21.8 0.0 0.00042 20.7 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 T040995_2 - 0.00049 20.3 0.0 0.0016 18.7 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.4 T040995_2 - 0.00071 19.7 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 T040995_2 - 0.00086 19.5 0.0 0.0021 18.3 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.4 T040995_2 - 0.028 14.9 0.0 0.067 13.7 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) BAGE PF08180.9 T295449_1 - 9.4e-11 41.5 0.6 1.5e-10 40.8 0.6 1.4 1 0 0 1 1 1 1 B melanoma antigen family GTF2I PF02946.12 T295449_2 - 1.7e-08 34.2 0.1 3e-08 33.4 0.1 1.3 1 0 0 1 1 1 1 GTF2I-like repeat AraC_binding_2 PF14525.4 T295449_2 - 0.015 14.9 0.1 0.022 14.3 0.1 1.2 1 0 0 1 1 1 0 AraC-binding-like domain AT_hook PF02178.17 T228582_3 - 0.099 12.4 5.9 0.33 10.9 5.9 1.9 1 0 0 1 1 1 0 AT hook motif CENP-B_dimeris PF09026.8 T040785_1 - 0.84 9.9 9.9 1.5 9.1 9.9 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF262 PF03235.12 T040785_1 - 3.8 7.5 13.1 5.5 6.9 13.1 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 DDHD PF02862.15 T040785_1 - 6.4 6.7 17.0 13 5.7 17.0 1.4 1 0 0 1 1 1 0 DDHD domain Connexin PF00029.17 T040785_2 - 0.054 13.1 1.3 0.09 12.4 1.3 1.3 1 0 0 1 1 1 0 Connexin Eapp_C PF10238.7 T040785_2 - 0.9 9.5 5.3 2.1 8.3 5.3 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein RR_TM4-6 PF06459.10 T040785_2 - 2.9 7.5 7.5 3.9 7.1 7.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1510 PF07423.9 T040785_3 - 0.013 14.9 19.1 0.019 14.3 19.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.12 T040785_3 - 0.032 12.4 34.8 0.047 11.9 34.8 1.1 1 0 0 1 1 1 0 CDC45-like protein SpoIIIAH PF12685.5 T040785_3 - 0.14 11.9 5.9 0.2 11.3 5.9 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Nop14 PF04147.10 T040785_3 - 0.48 8.5 29.8 0.67 8.0 29.8 1.0 1 0 0 1 1 1 0 Nop14-like family TT_ORF1 PF02956.12 T040785_3 - 0.82 8.1 33.0 1.3 7.5 33.0 1.2 1 0 0 1 1 1 0 TT viral orf 1 MIP-T3 PF10243.7 T040785_3 - 1.6 7.2 35.5 2.2 6.8 35.5 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 BUD22 PF09073.8 T040785_3 - 9.8 5.3 28.6 16 4.5 28.6 1.2 1 0 0 1 1 1 0 BUD22 Ig_3 PF13927.4 T069798_2 - 3.9e-25 88.1 3.3 1.6e-09 38.1 0.0 4.9 5 0 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.4 T069798_2 - 4.6e-21 74.8 0.3 3.1e-08 33.7 0.1 4.3 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 T069798_2 - 2.7e-10 40.2 0.0 0.003 17.6 0.0 4.5 4 1 0 4 4 4 3 Immunoglobulin domain fn3 PF00041.19 T069798_2 - 7.8e-07 29.2 0.0 4.1e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 Fibronectin type III domain I-set PF07679.14 T069798_2 - 4.9e-05 23.2 0.1 0.71 9.8 0.0 4.1 3 2 0 3 3 3 2 Immunoglobulin I-set domain C2-set_2 PF08205.10 T069798_2 - 0.00039 20.3 11.5 2.3 8.2 0.0 5.6 4 2 1 5 5 5 3 CD80-like C2-set immunoglobulin domain V-set PF07686.15 T069798_2 - 0.018 15.0 0.8 11 6.1 0.0 3.3 2 1 1 3 3 3 0 Immunoglobulin V-set domain DDE_Tnp_1_7 PF13843.4 T089049_2 - 2.9e-11 43.2 0.3 4e-11 42.7 0.3 1.1 1 0 0 1 1 1 1 Transposase IS4 DDE_Tnp_1_7 PF13843.4 T089049_3 - 2.2e-08 33.7 0.0 3e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 Transposase_22 PF02994.12 T346746_2 - 5.1e-64 216.3 8.9 2e-57 194.6 5.4 2.2 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T346746_3 - 3.7e-35 121.3 1.9 6.5e-35 120.5 1.9 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T346746_3 - 4.9e-14 51.8 14.6 2.6e-07 29.7 2.9 2.2 2 0 0 2 2 2 2 L1 transposable element HSBP1 PF06825.10 T346746_3 - 0.025 14.3 0.1 0.058 13.2 0.1 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Transposase_22 PF02994.12 T119711_1 - 1.4e-112 376.1 20.5 2.2e-110 368.9 20.5 2.4 1 1 0 1 1 1 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T119711_1 - 2.1e-06 27.4 0.5 7.4e-06 25.7 0.5 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T119711_1 - 0.00065 19.8 0.0 0.0028 17.7 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.25 T119711_3 - 3.1e-23 82.3 1.9 4.8e-23 81.7 1.9 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.18 T069065_1 - 1.1e-06 28.7 0.0 2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_1 PF00078.25 T069065_1 - 0.0002 20.8 0.0 0.00033 20.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T069065_3 - 1e-17 64.5 0.0 1.5e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 RNase H zf-CCHC PF00098.21 T069065_3 - 1e-06 28.4 3.2 2.9e-06 27.0 3.2 1.9 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.4 T069065_3 - 0.023 14.5 0.3 0.069 13.0 0.3 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-H2C2 PF09337.8 T069065_3 - 0.056 13.6 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger zf-H3C2 PF16721.3 T069065_3 - 0.16 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger like, probable DNA-binding RVT_3 PF13456.4 T069065_3 - 0.22 11.1 0.0 0.43 10.2 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like zf-CCHC_5 PF14787.4 T069065_3 - 0.73 9.5 10.8 0.068 12.8 4.2 2.7 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger RVT_1 PF00078.25 T218107_1 - 1.4e-17 63.9 2.1 1.9e-17 63.4 1.3 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T218107_3 - 1e-23 83.9 0.0 1.7e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.20 T313951_2 - 2e-12 46.6 0.0 3.5e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Defensin_3 PF08131.9 T313951_2 - 0.12 12.5 0.1 0.24 11.5 0.1 1.4 1 0 0 1 1 1 0 Defensin-like peptide family DUF4831 PF16115.3 T099497_2 - 0.18 10.7 1.2 9.7 5.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4831) Arylesterase PF01731.18 T381523_2 - 0.066 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Arylesterase rve PF00665.24 T338694_1 - 7.3e-23 80.9 0.0 1.3e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T338694_1 - 3.9e-09 36.7 0.0 6.7e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T338694_1 - 2.9e-06 26.8 0.0 4.4e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein DDE_Tnp_IS240 PF13610.4 T338694_1 - 0.012 15.7 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 DDE domain IN_DBD_C PF00552.19 T338694_2 - 2.2e-07 30.0 0.4 6e-07 28.5 0.4 1.8 1 0 0 1 1 1 1 Integrase DNA binding domain RVP PF00077.18 T338694_2 - 3e-05 24.1 0.0 6.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease GP41 PF00517.15 T338694_2 - 0.00042 20.1 0.2 0.00042 20.1 0.2 2.2 3 0 0 3 3 3 1 Retroviral envelope protein rve PF00665.24 T338694_2 - 0.0007 19.7 0.0 0.0017 18.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Borrelia_orfX PF04160.10 T338694_2 - 0.012 15.5 0.6 0.032 14.1 0.6 1.6 1 0 0 1 1 1 0 Orf-X protein RVT_1 PF00078.25 T338694_3 - 2.1e-05 24.0 0.0 3.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T338694_3 - 0.016 15.1 3.8 0.047 13.7 3.8 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.4 T338694_3 - 0.039 13.5 5.7 0.1 12.2 5.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger GPS PF01825.19 T229065_2 - 0.0011 19.4 0.2 0.016 15.7 0.1 2.8 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif GAIN PF16489.3 T229065_3 - 0.0034 16.7 0.0 0.0052 16.1 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain TLV_coat PF00429.17 T168001_1 - 1.9e-25 89.5 1.0 3.3e-25 88.7 1.0 1.3 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) rve PF00665.24 T168001_1 - 6.4e-10 39.1 0.0 1.1e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.21 T168001_1 - 0.0014 18.5 0.2 0.0039 17.1 0.2 1.9 1 0 0 1 1 1 1 Zinc knuckle Gag_MA PF01140.17 T168001_1 - 0.013 15.0 0.0 0.013 15.0 0.0 2.0 2 0 0 2 2 2 0 Matrix protein (MA), p15 DUF3704 PF12488.6 T168001_1 - 0.57 9.7 5.5 1.4 8.5 5.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) Gag_p30 PF02093.14 T168001_2 - 3e-14 52.9 0.0 4.9e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RNase_H PF00075.22 T168001_2 - 1.6e-13 51.0 0.0 2.5e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 RNase H RVP PF00077.18 T168001_2 - 0.017 15.3 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease rve PF00665.24 T268420_1 - 1.1e-17 64.2 0.0 2e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain HERV-K_env_2 PF13804.4 T268420_1 - 1.8e-10 40.7 0.1 3.1e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Integrase_Zn PF02022.17 T268420_1 - 5.1e-10 39.0 0.6 1.3e-09 37.7 0.6 1.7 1 0 0 1 1 1 1 Integrase Zinc binding domain IN_DBD_C PF00552.19 T268420_1 - 4.5e-05 22.5 0.5 0.00011 21.3 0.5 1.7 1 0 0 1 1 1 1 Integrase DNA binding domain RVT_thumb PF06817.12 T268420_2 - 7.1e-30 102.4 0.1 1.6e-29 101.3 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RNase_H PF00075.22 T268420_2 - 1.7e-11 44.4 0.0 3.3e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 RNase H HERV-K_REC PF15695.3 T268420_2 - 0.00023 21.0 1.0 0.00041 20.2 1.0 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 RVP PF00077.18 T268420_3 - 1.5e-21 76.4 0.1 3e-21 75.4 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease dUTPase PF00692.17 T268420_3 - 7.8e-16 57.8 0.0 1.3e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 dUTPase G-patch PF01585.21 T268420_3 - 9.9e-09 34.9 0.4 1.7e-08 34.1 0.4 1.4 1 0 0 1 1 1 1 G-patch domain gag-asp_proteas PF13975.4 T268420_3 - 0.039 14.4 0.0 0.066 13.6 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease rve PF00665.24 T168798_1 - 1.2e-18 67.3 0.0 1.8e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T168798_1 - 2.4e-09 37.2 1.3 5.4e-09 36.0 1.3 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Gag_MA PF01140.17 T168798_2 - 1.3e-13 50.6 0.0 2.7e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Matrix protein (MA), p15 RVP PF00077.18 T168798_2 - 1.5e-10 41.1 0.0 3e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.4 T168798_2 - 0.049 14.2 0.0 0.088 13.4 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T168798_2 - 0.069 13.6 0.1 0.13 12.7 0.1 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Phage_ASH PF10554.7 T172640_2 - 0.17 12.1 0.7 0.43 10.8 0.7 1.6 1 0 0 1 1 1 0 Ash protein family RVT_1 PF00078.25 T375477_1 - 1.5e-23 83.3 0.4 2.7e-23 82.5 0.4 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.4 T375477_1 - 0.0022 17.5 0.4 0.24 10.8 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4417) Transposase_22 PF02994.12 T375477_2 - 2.2e-90 303.1 13.6 8.4e-81 271.5 9.0 4.4 5 0 0 5 5 5 3 L1 transposable element RVT_1 PF00078.25 T375477_2 - 1.1e-39 136.1 11.4 1.2e-29 103.3 5.5 2.9 2 1 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T375477_2 - 4.4e-07 30.0 0.0 5.5e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DUF1882 PF08966.9 T375477_2 - 0.44 10.7 5.6 9.5 6.4 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1882) NAD_binding_1 PF00175.19 T375477_2 - 2.9 8.4 6.8 8.5 6.9 0.6 2.7 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Transposase_22 PF02994.12 T375477_3 - 1.6e-64 217.9 38.8 3.7e-16 58.8 4.2 5.3 5 0 0 5 5 5 5 L1 transposable element DUF4705 PF15788.3 T322052_1 - 3.3e-20 71.9 242.6 1.4e-06 28.3 6.1 21.2 15 4 3 18 18 18 12 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322052_2 - 1.1e-27 95.9 256.9 2e-14 53.4 12.6 22.6 9 5 10 20 20 20 9 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322052_3 - 3.4e-47 158.3 272.5 2.5e-18 65.9 10.8 22.4 11 6 9 21 21 21 17 Domain of unknown function (DUF4705) SDA1 PF05285.10 T251537_1 - 0.0018 17.6 56.1 0.0018 17.6 56.1 1.7 2 0 0 2 2 2 1 SDA1 DUF913 PF06025.10 T251537_2 - 6.7 5.4 8.1 13 4.5 8.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF1028 PF06267.10 T258962_2 - 5.4 6.6 6.6 10 5.7 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) DUF4705 PF15788.3 T323213_1 - 1.9e-85 280.8 461.7 3.2e-17 62.3 8.0 42.4 23 13 16 40 40 40 30 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323213_2 - 2.1e-67 223.0 480.8 3.3e-08 33.5 4.4 41.0 26 12 10 36 36 36 28 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323213_3 - 1.8e-36 124.0 88.5 1.2e-15 57.3 9.2 40.5 20 12 15 36 36 36 17 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322053_1 - 5.4e-29 100.0 219.1 1.8e-14 53.5 12.6 19.8 5 4 11 17 17 17 9 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322053_2 - 4.8e-47 157.8 254.3 2.3e-18 66.0 10.8 21.3 12 5 8 21 21 21 16 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322053_3 - 2e-07 31.0 218.3 0.0028 17.7 6.0 20.6 15 4 3 18 18 18 11 Domain of unknown function (DUF4705) RnaseA PF00074.18 T100535_1 - 0.0002 21.7 0.0 0.00039 20.8 0.0 1.4 1 0 0 1 1 1 1 Pancreatic ribonuclease RnaseA PF00074.18 T100535_3 - 2.5e-05 24.7 2.9 5.7e-05 23.5 2.9 1.5 1 0 0 1 1 1 1 Pancreatic ribonuclease Gag_p30 PF02093.14 T089225_1 - 6.8e-11 42.0 5.1 2.2e-08 33.8 0.6 2.2 1 1 1 2 2 2 2 Gag P30 core shell protein rve PF00665.24 T089225_1 - 1.7e-06 28.1 0.0 2.8e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.18 T089225_1 - 8.7e-06 25.8 0.0 1.7e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.4 T089225_1 - 0.057 13.1 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Asp_protease_2 PF13650.4 T089225_1 - 0.11 13.0 0.1 0.19 12.3 0.1 1.3 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T089225_1 - 0.2 12.1 0.0 0.33 11.4 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Gag_p30 PF02093.14 T089225_2 - 1.5e-20 73.5 0.1 2.2e-20 73.0 0.1 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein zf-H2C2 PF09337.8 T089225_2 - 2.3e-07 30.8 0.2 6.5e-07 29.4 0.2 1.9 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RNase_H PF00075.22 T089225_3 - 2.4e-18 66.6 0.1 4e-18 65.8 0.1 1.3 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T089225_3 - 6.1e-13 48.7 0.0 1.1e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T089225_3 - 0.00026 20.4 0.3 0.00058 19.3 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Gag_p24 PF00607.18 T230568_1 - 1e-69 234.4 1.3 1.7e-69 233.6 0.3 1.8 2 0 0 2 2 2 1 gag gene protein p24 (core nucleocapsid protein) HERV-K_env_2 PF13804.4 T230568_1 - 7e-65 217.8 2.8 1.3e-64 216.9 2.8 1.4 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_REC PF15695.3 T230568_1 - 1.5e-28 98.5 5.6 4.2e-28 97.1 5.6 1.8 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Gag_p10 PF02337.15 T230568_1 - 2.1e-27 94.7 0.2 4.9e-27 93.5 0.2 1.6 1 0 0 1 1 1 1 Retroviral GAG p10 protein RVT_thumb PF06817.12 T230568_1 - 7.5e-16 57.5 0.0 2.3e-15 55.9 0.0 1.9 1 0 0 1 1 1 1 Reverse transcriptase thumb domain dUTPase PF00692.17 T230568_1 - 4.4e-10 39.2 0.0 8.8e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 dUTPase IN_DBD_C PF00552.19 T230568_1 - 2.1e-06 26.8 1.2 4.4e-06 25.8 1.2 1.5 1 0 0 1 1 1 1 Integrase DNA binding domain zf-CCHC PF00098.21 T230568_1 - 1e-05 25.3 2.5 1e-05 25.3 2.5 3.4 3 0 0 3 3 3 1 Zinc knuckle RVT_1 PF00078.25 T230568_1 - 0.0012 18.3 0.1 0.0025 17.3 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GP41 PF00517.15 T230568_1 - 0.0058 16.4 0.0 0.0058 16.4 0.0 1.8 2 0 0 2 2 2 1 Retroviral envelope protein rve PF00665.24 T230568_2 - 1e-24 86.9 0.0 2.2e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_5 PF14787.4 T230568_2 - 3.6e-19 68.0 7.6 8.4e-19 66.9 7.6 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Integrase_Zn PF02022.17 T230568_2 - 1e-14 54.0 2.7 2.4e-14 52.9 2.7 1.7 1 0 0 1 1 1 1 Integrase Zinc binding domain RNase_H PF00075.22 T230568_2 - 3.6e-08 33.6 0.0 6.4e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 RNase H GP41 PF00517.15 T230568_2 - 2.1e-05 24.3 1.4 3.8e-05 23.5 1.4 1.3 1 0 0 1 1 1 1 Retroviral envelope protein DDE_Tnp_IS240 PF13610.4 T230568_2 - 0.035 14.2 0.0 0.055 13.6 0.0 1.3 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.25 T230568_2 - 0.036 13.4 0.1 0.066 12.6 0.1 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.12 T230568_3 - 9.8e-08 31.5 0.4 1.8e-07 30.6 0.4 1.4 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVT_1 PF00078.25 T230568_3 - 2.4e-05 23.8 0.0 3.3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Borrelia_orfX PF04160.10 T230568_3 - 0.018 15.0 0.4 0.03 14.2 0.4 1.2 1 0 0 1 1 1 0 Orf-X protein RVP PF00077.18 T230568_3 - 0.16 12.2 0.1 1.5 9.0 0.1 2.1 1 1 1 2 2 2 0 Retroviral aspartyl protease RVT_1 PF00078.25 T247246_1 - 4.2e-25 88.4 0.1 5.7e-25 88.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T247246_2 - 2.3e-11 43.5 0.7 3.6e-11 42.9 0.7 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T247246_3 - 3.8e-07 29.5 0.5 7.8e-07 28.4 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Ytca PF17090.3 T018784_3 - 0.072 13.5 2.9 3.2 8.2 0.1 2.9 2 0 0 2 2 2 0 Uncharacterised protein family DUF1028 PF06267.10 T259007_1 - 5.3 6.7 6.6 10 5.7 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) IQ PF00612.25 T272764_3 - 0.0014 18.2 0.1 0.0042 16.6 0.1 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF2070 PF09843.7 T164980_3 - 6.7 4.7 7.2 8.5 4.4 7.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) CCDC24 PF15669.3 T246245_2 - 2.5 7.8 5.5 5.5 6.7 5.5 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family RVT_1 PF00078.25 T375364_1 - 1.5e-12 47.4 0.0 2.2e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T375364_2 - 1.6e-06 28.2 0.0 2.9e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 RNase H PAN_2 PF08276.9 T172827_2 - 0.06 13.3 0.6 0.11 12.4 0.6 1.3 1 0 0 1 1 1 0 PAN-like domain Herpes_BLLF1 PF05109.11 T172827_3 - 0.002 16.1 10.7 0.0078 14.1 1.7 2.0 1 1 1 2 2 2 2 Herpes virus major outer envelope glycoprotein (BLLF1) RNase_H PF00075.22 T172322_2 - 2.7e-05 24.3 0.0 4.4e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 RNase H Lipocalin PF00061.21 T368846_3 - 1.6e-05 25.0 0.0 2.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Mit_proteolip PF08039.9 T028901_2 - 0.0001 22.4 1.5 0.00022 21.3 1.5 1.5 1 0 0 1 1 1 1 Mitochondrial proteolipid IN_DBD_C PF00552.19 T338693_1 - 2.3e-07 29.9 0.4 5.8e-07 28.6 0.4 1.7 1 0 0 1 1 1 1 Integrase DNA binding domain RVP PF00077.18 T338693_1 - 2.7e-05 24.2 0.0 6e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T338693_1 - 0.00067 19.7 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain GP41 PF00517.15 T338693_1 - 0.0034 17.1 8.4 0.0034 17.1 8.4 2.7 3 1 0 3 3 3 1 Retroviral envelope protein Borrelia_orfX PF04160.10 T338693_1 - 0.011 15.6 0.6 0.031 14.2 0.6 1.7 1 0 0 1 1 1 0 Orf-X protein RVT_1 PF00078.25 T338693_2 - 2.1e-05 24.0 0.0 3.4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T338693_2 - 0.014 15.3 3.8 0.046 13.7 3.8 1.9 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.4 T338693_2 - 0.038 13.6 5.7 0.1 12.2 5.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger rve PF00665.24 T338693_3 - 6.8e-23 81.0 0.0 1.2e-22 80.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T338693_3 - 3.8e-09 36.8 0.0 6.5e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 RNase H DDE_Tnp_IS240 PF13610.4 T338693_3 - 0.012 15.7 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 DDE domain VCX_VCY PF15231.4 T381765_1 - 2.4e-06 28.1 0.1 3.3e-06 27.7 0.1 1.1 1 0 0 1 1 1 1 Variable charge X/Y family AMP-binding PF00501.26 T228736_2 - 2.1e-05 23.2 0.0 2.1e-05 23.2 0.0 1.4 2 0 0 2 2 2 1 AMP-binding enzyme ARF7EP_C PF14949.4 T352863_1 - 3.8 8.0 8.2 8.7 6.9 8.2 1.5 1 0 0 1 1 1 0 ARF7 effector protein C-terminus Transposase_22 PF02994.12 T081232_2 - 5.2e-54 183.4 2.6 5.2e-54 183.4 2.6 1.8 2 0 0 2 2 2 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T081232_2 - 0.00033 20.4 0.0 0.0006 19.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF1725 PF08333.9 T081232_3 - 9.8e-06 24.9 0.1 2e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) TAF8_C PF10406.7 T284134_3 - 0.069 13.6 0.1 0.16 12.4 0.1 1.6 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term SCIFF PF13165.4 T196646_2 - 0.12 12.2 0.6 0.31 10.9 0.6 1.7 1 0 0 1 1 1 0 Six-cysteine peptide SCIFF DUF3678 PF12435.6 T179757_1 - 1 8.5 8.2 0.22 10.7 0.5 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) DUF1725 PF08333.9 T211562_1 - 1.5e-06 27.5 0.3 3.8e-06 26.3 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Collagen PF01391.16 T211562_1 - 0.0033 17.0 40.6 0.049 13.2 17.3 2.8 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Plasmodium_Vir PF05795.9 T305690_2 - 0.024 13.9 8.1 0.035 13.4 8.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF1556 PF07590.9 T147662_3 - 1.2 9.4 9.0 3 8.1 9.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1556) RVT_1 PF00078.25 T081660_1 - 1.4e-32 112.9 2.5 2.1e-32 112.3 2.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T081660_1 - 1.7e-07 30.6 0.8 3.7e-07 29.5 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos_2 PF14529.4 T081660_1 - 0.003 17.3 1.4 0.006 16.3 1.4 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Transposase_22 PF02994.12 T081660_2 - 2.7e-86 289.6 21.1 5.8e-86 288.5 21.1 1.5 1 0 0 1 1 1 1 L1 transposable element Seryl_tRNA_N PF02403.20 T081660_2 - 0.0003 20.9 4.6 0.00058 19.9 4.6 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain HSBP1 PF06825.10 T081660_2 - 0.29 11.0 7.4 1.2 8.9 1.2 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 ABC_tran_CTD PF16326.3 T081660_2 - 5 7.3 8.2 10 6.3 8.2 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain Gag_p30 PF02093.14 T093386_1 - 7.2e-55 185.7 0.8 1.2e-54 184.9 0.8 1.4 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T093386_1 - 1.9e-08 34.0 0.0 3.6e-08 33.0 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.18 T093386_1 - 3.7e-08 33.4 0.0 6.3e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T093386_1 - 2e-06 27.9 0.0 3.8e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T093386_1 - 3.6e-05 23.8 0.4 0.00011 22.2 0.4 2.0 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Gag_p24 PF00607.18 T093386_1 - 0.04 13.6 0.2 0.086 12.6 0.1 1.4 1 1 0 1 1 1 0 gag gene protein p24 (core nucleocapsid protein) RNase_H PF00075.22 T093386_3 - 8e-11 42.2 0.0 1.7e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 RNase H Gag_p24 PF00607.18 T168760_1 - 2.1e-35 122.3 0.0 3.3e-35 121.7 0.0 1.3 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) GP41 PF00517.15 T168760_1 - 9e-09 35.3 4.8 1.6e-08 34.5 4.8 1.3 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_REC PF15695.3 T168760_1 - 0.0004 20.3 0.7 0.00092 19.1 0.7 1.5 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Gag_p30 PF02093.14 T168760_1 - 0.02 14.3 0.0 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein G-patch PF01585.21 T168760_1 - 0.042 13.7 0.3 0.073 12.9 0.3 1.4 1 0 0 1 1 1 0 G-patch domain RVT_thumb PF06817.12 T168760_2 - 2.1e-18 65.7 0.1 4.4e-18 64.6 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVT_1 PF00078.25 T168760_2 - 1.1e-08 34.8 0.0 1.7e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_Zn PF02022.17 T168760_2 - 0.00032 20.4 0.4 0.00097 18.9 0.4 1.8 1 0 0 1 1 1 1 Integrase Zinc binding domain rve PF00665.24 T168760_2 - 0.0035 17.4 0.1 0.054 13.6 0.1 2.2 2 0 0 2 2 2 1 Integrase core domain GP41 PF00517.15 T168760_2 - 0.032 13.9 0.5 0.05 13.3 0.5 1.2 1 0 0 1 1 1 0 Retroviral envelope protein RNase_H PF00075.22 T168760_3 - 3e-10 40.3 0.0 5e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p10 PF02337.15 T168760_3 - 2.5e-09 36.7 0.2 4.5e-09 35.9 0.2 1.4 1 0 0 1 1 1 1 Retroviral GAG p10 protein IN_DBD_C PF00552.19 T168760_3 - 0.0033 16.5 0.5 0.0083 15.3 0.5 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain POM121 PF15229.4 T361769_1 - 3.1e-24 85.8 5.8 1e-23 84.2 5.8 1.8 1 0 0 1 1 1 1 POM121 family Exo_endo_phos_2 PF14529.4 T264774_3 - 5.5e-07 29.3 0.9 1.5e-06 27.9 0.9 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF4391 PF14335.4 T264774_3 - 0.0003 20.4 5.8 0.00072 19.2 5.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4391) Exo_endo_phos PF03372.21 T264774_3 - 0.064 13.4 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Gag_p30 PF02093.14 T089139_2 - 1.8e-14 53.6 0.0 2.6e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein zf-CCHC PF00098.21 T089139_2 - 1.3e-05 24.9 1.0 1.3e-05 24.9 1.0 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T089139_2 - 0.027 14.1 2.7 0.072 12.7 2.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.4 T089139_2 - 0.1 12.3 1.1 0.36 10.5 1.1 2.0 1 0 0 1 1 1 0 Zinc knuckle FAM183 PF14886.4 T341320_2 - 0.00075 20.1 0.1 0.0016 19.0 0.1 1.5 1 0 0 1 1 1 1 FAM183A and FAM183B related DUF1725 PF08333.9 T341320_3 - 0.1 12.2 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) UPAR_LY6 PF00021.19 T176634_2 - 1.1e-06 29.1 25.2 0.00082 19.9 5.5 3.7 3 0 0 3 3 3 3 u-PAR/Ly-6 domain KKLCAg1 PF15204.4 T379174_3 - 3.3e-33 113.5 0.6 4.9e-33 112.9 0.6 1.2 1 0 0 1 1 1 1 Kita-kyushu lung cancer antigen 1 HAP2-GCS1 PF10699.7 T138426_2 - 0.055 13.3 3.7 4.2 7.3 0.3 2.9 2 0 0 2 2 2 0 Male gamete fusion factor DUF3704 PF12488.6 T155648_2 - 0.083 12.4 7.8 0.021 14.3 4.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3704) PhoPQ_related PF10142.7 T155648_3 - 1.6e-16 59.8 0.0 2.4e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein SR-25 PF10500.7 T258756_1 - 1 8.8 4.8 1.6 8.1 4.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein POM121 PF15229.4 T361763_2 - 2e-23 83.2 5.8 2e-23 83.2 5.8 2.3 2 0 0 2 2 2 1 POM121 family Transposase_22 PF02994.12 T227000_1 - 6.6e-25 87.6 4.6 4.6e-20 71.7 2.3 2.2 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T227000_1 - 3e-06 26.8 0.3 3e-06 26.8 0.3 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T227000_2 - 1e-14 54.5 0.2 1.8e-14 53.6 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T137783_1 - 0.01 15.4 0.5 0.01 15.4 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1725) DUF4417 PF14386.4 T089819_1 - 0.026 14.0 0.1 0.041 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) RVT_1 PF00078.25 T089819_3 - 2.3e-43 148.1 0.2 3.4e-43 147.6 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GAIN PF16489.3 T229066_3 - 3.2e-06 26.6 0.0 0.013 14.8 0.0 2.1 2 0 0 2 2 2 2 GPCR-Autoproteolysis INducing (GAIN) domain PAT1 PF09770.7 T316851_1 - 5.6 5.0 26.5 11 4.0 26.5 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GASA PF02704.12 T062665_3 - 2.3 8.3 8.2 17 5.5 8.2 2.6 1 0 0 1 1 1 0 Gibberellin regulated protein Trypan_PARP PF05887.9 T278161_3 - 3.1 7.7 22.4 1.1 9.1 7.4 2.3 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) SDA1 PF05285.10 T251538_2 - 0.0017 17.7 56.1 0.0017 17.7 56.1 1.7 2 0 0 2 2 2 1 SDA1 DUF913 PF06025.10 T251538_3 - 6.4 5.5 8.1 12 4.6 8.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Colipase-like PF15083.4 T090344_1 - 1.2e-11 44.5 2.3 2.4e-11 43.5 2.3 1.4 1 0 0 1 1 1 1 Colipase-like Colipase-like PF15083.4 T090344_3 - 7.5e-33 112.4 10.9 1.4e-32 111.5 10.9 1.4 1 0 0 1 1 1 1 Colipase-like Colipase PF01114.16 T090344_3 - 3.1 7.4 10.9 2.6 7.6 1.8 2.8 2 0 0 2 2 2 0 Colipase, N-terminal domain Gag_p30 PF02093.14 T236793_1 - 1e-26 93.6 1.5 1.8e-25 89.6 0.1 2.2 2 0 0 2 2 2 1 Gag P30 core shell protein rve PF00665.24 T236793_1 - 2.7e-15 56.5 0.0 4.7e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T236793_1 - 4.7e-10 39.2 0.0 7e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T236793_2 - 9.1e-13 47.7 0.5 1.4e-12 47.1 0.5 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T236793_2 - 0.003 17.0 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T236793_3 - 9.1e-09 35.5 0.1 1.8e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 RNase H Gag_MA PF01140.17 T236793_3 - 0.0016 18.0 0.0 0.0032 17.0 0.0 1.4 1 0 0 1 1 1 1 Matrix protein (MA), p15 Serpin PF00079.18 T295984_2 - 2.3e-05 23.7 0.0 3.3e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PHO4 PF01384.18 T236007_1 - 1.1e-05 24.5 0.3 0.0021 17.1 0.0 2.4 2 0 0 2 2 2 2 Phosphate transporter family Toxin_18 PF08087.9 T286608_2 - 0.42 10.5 6.2 0.11 12.4 2.4 2.1 2 0 0 2 2 2 0 Conotoxin O-superfamily Glyco_hydro_2_C PF02836.15 T286608_3 - 2.8e-17 62.7 0.1 3.7e-17 62.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Phage_lysis PF03245.11 T320404_2 - 0.73 9.8 2.7 0.86 9.6 1.2 1.8 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein AMP-binding PF00501.26 T228722_1 - 2e-05 23.2 0.0 2.8e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme MIP-T3 PF10243.7 T228722_2 - 0.56 8.7 9.7 0.91 8.0 9.7 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Transposase_22 PF02994.12 T103700_3 - 2.2e-142 474.2 20.5 2.9e-142 473.7 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103700_3 - 0.03 14.4 0.0 0.058 13.5 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103700_3 - 0.061 13.0 10.5 0.11 12.1 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103700_3 - 0.062 13.7 2.8 0.11 12.8 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103700_3 - 0.35 11.3 5.0 0.71 10.3 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103700_3 - 0.44 9.8 12.3 0.76 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103700_3 - 1.2 9.2 11.3 0.015 15.3 2.1 2.3 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103700_3 - 3.3 7.9 7.6 5.8 7.1 6.8 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein RNase_H PF00075.22 T172339_2 - 3.4e-05 23.9 0.0 5.9e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 RNase H UPAR_LY6 PF00021.19 T176624_3 - 2.3e-06 28.1 28.1 0.00085 19.8 5.5 3.7 3 0 0 3 3 3 3 u-PAR/Ly-6 domain DUF4417 PF14386.4 T249044_3 - 0.013 15.0 0.1 0.022 14.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) YlbE PF14003.4 T249044_3 - 1.2 9.5 6.4 1.9 8.8 0.0 3.1 3 0 0 3 3 3 0 YlbE-like protein DUF4705 PF15788.3 T323218_1 - 2.5e-55 184.4 599.1 1.8e-15 56.7 9.2 52.9 32 14 14 47 47 47 30 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323218_2 - 1.4e-44 149.9 580.7 2.4e-08 33.9 7.0 48.8 28 15 18 46 46 46 25 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323218_3 - 5.8e-105 343.2 606.3 4.9e-17 61.7 8.0 54.3 34 14 16 51 51 51 39 Domain of unknown function (DUF4705) Myb_DNA-bind_4 PF13837.4 T294746_2 - 1e-05 25.7 0.2 1.7e-05 25.0 0.2 1.3 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF1048 PF06304.9 T294746_2 - 0.011 16.1 0.0 4.1 7.8 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1048) tRNA_NucTran2_2 PF13735.4 T294746_2 - 0.13 12.2 0.3 0.2 11.5 0.3 1.2 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative DUF4632 PF15451.4 T099557_1 - 1.6e-05 24.8 1.2 17 5.4 0.0 7.0 5 3 5 10 10 10 3 Domain of unknown function (DUF4632) DUF2325 PF10087.7 T099557_1 - 0.068 13.2 1.2 1.5e+02 2.5 0.0 5.4 5 2 3 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2325) SOCS PF12610.6 T099557_1 - 0.64 10.3 5.8 45 4.4 0.1 4.5 4 0 0 4 4 4 0 Suppressor of cytokine signalling TALPID3 PF15324.4 T099557_2 - 0.014 12.9 0.1 0.014 12.9 0.1 2.5 1 1 1 2 2 2 0 Hedgehog signalling target Ectatomin PF06457.9 T337208_1 - 0.00037 20.2 31.3 42 4.0 0.0 13.5 15 0 0 15 15 15 6 Ectatomin Ectatomin PF06457.9 T337208_3 - 0.0048 16.6 24.7 45 3.9 0.0 10.7 13 0 0 13 13 13 6 Ectatomin CitMHS PF03600.14 T090155_2 - 0.0061 15.7 19.2 0.0093 15.1 19.2 1.2 1 0 0 1 1 1 1 Citrate transporter DUF912 PF06024.10 T090155_2 - 1.1 9.5 0.0 1.1 9.5 0.0 3.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PHO4 PF01384.18 T090155_2 - 8.3 5.2 16.4 80 2.0 18.5 1.3 1 1 0 1 1 1 0 Phosphate transporter family Transposase_1 PF01359.16 T271699_3 - 1.8e-21 75.7 0.4 4.5e-21 74.4 0.4 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) SoxG PF04268.10 T173078_1 - 0.034 14.2 0.1 0.055 13.5 0.1 1.4 1 0 0 1 1 1 0 Sarcosine oxidase, gamma subunit family Phospho_p8 PF10195.7 T325319_3 - 0.088 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 CBM9_2 PF16011.3 T258364_1 - 0.13 11.8 0.0 37 3.8 0.0 4.0 4 1 1 5 5 5 0 Carbohydrate-binding family 9 Borrelia_lipo_1 PF05714.9 T258364_1 - 0.53 9.9 3.4 20 4.7 0.3 4.4 4 1 1 5 5 5 0 Borrelia burgdorferi virulent strain associated lipoprotein Sec34 PF04136.13 T258364_1 - 0.65 9.7 6.0 6.3 6.5 0.2 5.0 4 1 0 5 5 5 0 Sec34-like family Gag_p30 PF02093.14 T172326_2 - 0.025 13.9 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein Gag_p30 PF02093.14 T172326_3 - 4.4e-39 134.1 1.6 3.5e-19 69.0 0.0 2.2 2 0 0 2 2 2 2 Gag P30 core shell protein Gag_MA PF01140.17 T172326_3 - 5.5e-22 77.7 0.2 1.1e-21 76.7 0.2 1.4 1 0 0 1 1 1 1 Matrix protein (MA), p15 RNase_H PF00075.22 T172326_3 - 1.9e-16 60.4 0.0 3.4e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 RNase H RVP PF00077.18 T172326_3 - 2.2e-06 27.7 0.0 4.5e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.8 T172326_3 - 7e-05 22.9 0.3 0.00016 21.8 0.3 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Asp_protease_2 PF13650.4 T172326_3 - 0.014 15.9 0.1 0.026 15.1 0.1 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T172326_3 - 0.049 14.1 0.1 0.093 13.2 0.1 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Flavokinase PF01687.15 T099750_2 - 0.0004 20.5 0.3 54 4.0 0.0 4.7 2 1 2 5 5 5 4 Riboflavin kinase Transposase_22 PF02994.12 T103483_3 - 4.5e-120 400.7 18.8 6.5e-120 400.2 18.8 1.2 1 0 0 1 1 1 1 L1 transposable element Seryl_tRNA_N PF02403.20 T103483_3 - 0.0086 16.2 5.8 0.016 15.3 5.8 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Spectrin PF00435.19 T103483_3 - 0.038 14.3 2.6 0.095 13.1 2.6 1.6 1 0 0 1 1 1 0 Spectrin repeat GAS PF13851.4 T103483_3 - 0.044 13.0 8.5 0.083 12.1 8.5 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103483_3 - 0.048 13.7 2.0 0.072 13.1 0.6 2.0 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103483_3 - 0.091 12.9 4.1 0.24 11.5 4.1 1.7 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Syntaxin-6_N PF09177.9 T103483_3 - 0.12 12.8 4.0 0.28 11.6 4.0 1.6 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF342 PF03961.11 T103483_3 - 0.15 10.5 7.1 0.25 9.8 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4613 PF15390.4 T103483_3 - 0.19 9.9 6.1 0.28 9.4 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) IncA PF04156.12 T103483_3 - 0.24 11.0 7.2 0.49 10.0 7.2 1.4 1 0 0 1 1 1 0 IncA protein APG6 PF04111.10 T103483_3 - 0.24 10.6 8.0 0.35 10.1 8.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1664 PF07889.10 T103483_3 - 0.32 10.9 1.5 0.58 10.0 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) XhlA PF10779.7 T103483_3 - 1.8 8.7 5.8 8.2 6.6 0.6 2.5 2 0 0 2 2 2 0 Haemolysin XhlA TPR_MLP1_2 PF07926.10 T103483_3 - 2.7 7.9 7.6 7.4 6.5 7.6 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein ATG16 PF08614.9 T103483_3 - 7.9 6.5 12.9 20 5.1 12.9 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) CCDC144C PF14915.4 T018733_1 - 3.9e-61 206.7 37.8 4.4e-36 124.4 14.1 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018733_1 - 0.0076 16.1 1.1 0.0076 16.1 1.1 3.0 3 0 0 3 3 3 1 Laminin Domain II CCDC144C PF14915.4 T018733_2 - 7.2e-17 61.3 9.6 7.2e-17 61.3 9.6 1.6 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018733_2 - 4.8e-09 36.4 0.0 4.8e-09 36.4 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3496) DUF3496 PF12001.6 T018733_3 - 6.9e-17 61.7 7.5 1.5e-16 60.6 7.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3496) TGF_beta PF00019.18 T282639_3 - 3.3e-08 34.2 2.2 5.8e-08 33.4 2.2 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain FRG2 PF15315.4 T034774_1 - 1e-07 32.2 0.1 1.5e-07 31.6 0.1 1.1 1 0 0 1 1 1 1 Facioscapulohumeral muscular dystrophy candidate 2 FRG2 PF15315.4 T034774_2 - 1e-06 28.9 0.7 1.4e-06 28.5 0.0 1.4 2 0 0 2 2 2 1 Facioscapulohumeral muscular dystrophy candidate 2 DUF4705 PF15788.3 T323254_1 - 0.0089 16.1 34.3 0.029 14.5 15.6 5.2 3 1 0 3 3 3 2 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323254_3 - 4.5e-05 23.4 22.3 0.00029 20.9 6.0 8.1 8 2 2 10 10 10 2 Domain of unknown function (DUF4705) DDE_1 PF03184.17 T045959_1 - 7e-18 64.7 0.0 1.8e-17 63.3 0.0 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 T045959_1 - 9.9e-09 35.0 0.0 1.9e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.11 T045959_2 - 0.00017 21.0 0.2 0.00034 20.1 0.2 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DDE_1 PF03184.17 T045959_2 - 0.0029 17.1 1.1 0.0071 15.8 0.2 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease RhoGAP PF00620.25 T131217_3 - 1e-39 135.7 0.0 1.6e-39 135.0 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Gag_p10 PF02337.15 T172005_3 - 1.1e-13 50.7 0.4 2e-13 49.9 0.4 1.4 1 0 0 1 1 1 1 Retroviral GAG p10 protein VCX_VCY PF15231.4 T381766_1 - 2.2e-06 28.2 0.1 3.2e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Variable charge X/Y family SAPS PF04499.13 T081035_1 - 0.84 8.2 13.2 1.1 7.8 13.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.15 T081035_1 - 9 4.8 27.4 14 4.2 27.4 1.1 1 0 0 1 1 1 0 Presenilin Mucin-like PF16058.3 T211109_3 - 3 7.8 105.0 0.38 10.7 38.4 3.8 2 1 2 4 4 4 0 Mucin-like Toxin_13 PF07822.9 T229257_3 - 0.028 14.4 0.3 0.028 14.4 0.3 2.1 2 0 0 2 2 2 0 Neurotoxin B-IV-like protein DuoxA PF10204.7 T338867_2 - 0.075 11.9 7.8 0.32 9.8 7.7 1.9 2 0 0 2 2 2 0 Dual oxidase maturation factor Glycophorin_A PF01102.16 T338867_2 - 0.23 11.6 3.7 0.64 10.1 3.7 1.7 1 0 0 1 1 1 0 Glycophorin A DUF4191 PF13829.4 T338867_2 - 3.5 6.8 5.4 5.3 6.2 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Gag_p30 PF02093.14 T297826_3 - 0.00025 20.5 0.0 0.00042 19.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T297826_3 - 0.0074 15.7 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T263710_1 - 1.8e-35 122.3 0.5 2.9e-35 121.7 0.5 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T263710_2 - 1.5e-07 31.1 0.0 2.4e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TLV_coat PF00429.17 T238784_3 - 9.1e-09 34.4 2.0 4.1e-08 32.3 2.0 1.9 1 1 0 1 1 1 1 ENV polyprotein (coat polyprotein) RVT_1 PF00078.25 T374590_1 - 7.8e-16 58.1 0.0 1.2e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TLV_coat PF00429.17 T374590_1 - 3.2e-07 29.3 3.8 0.0033 16.1 2.5 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) Methyltransf_6 PF03737.13 T374590_1 - 0.055 13.5 0.0 0.094 12.8 0.0 1.2 1 0 0 1 1 1 0 Demethylmenaquinone methyltransferase Lambda_Kil PF06301.9 T235902_1 - 0.0024 17.3 0.6 5.6 6.5 0.1 3.6 4 0 0 4 4 4 2 Bacteriophage lambda Kil protein YtxH PF12732.5 T235902_2 - 0.017 15.5 0.0 8.4 6.9 0.0 2.3 2 0 0 2 2 2 0 YtxH-like protein Lambda_Kil PF06301.9 T235902_2 - 0.15 11.5 0.1 15 5.1 0.0 3.1 3 0 0 3 3 3 0 Bacteriophage lambda Kil protein Transposase_22 PF02994.12 T256679_1 - 8.9e-27 93.8 0.2 1.4e-26 93.1 0.2 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T256679_1 - 7e-17 61.5 1.8 1e-16 61.0 1.8 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T256679_2 - 2.1e-33 115.6 2.2 3.2e-33 115.0 2.2 1.2 1 0 0 1 1 1 1 L1 transposable element DUF1725 PF08333.9 T256679_2 - 5.6e-05 22.5 0.2 0.00012 21.5 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos PF03372.21 T256679_2 - 0.0072 16.4 0.0 0.06 13.5 0.0 2.1 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.25 T256679_3 - 1.1e-06 28.3 0.0 1.9e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) UPF0184 PF03670.11 T256679_3 - 0.26 11.5 2.0 0.53 10.6 2.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) ADAM_CR PF08516.10 T106641_1 - 2.1e-21 76.3 2.8 2.1e-21 76.3 2.8 3.6 3 1 1 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.21 T106641_1 - 2.7e-16 60.0 26.2 2.7e-16 60.0 26.2 3.3 3 0 0 3 3 3 1 Disintegrin Pep_M12B_propep PF01562.17 T106641_2 - 1.9e-16 60.5 0.0 4.5e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.17 T106641_2 - 5.3e-15 55.7 0.5 8.3e-15 55.1 0.5 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 T106641_2 - 0.0062 16.6 0.8 0.01 15.8 0.8 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T106641_2 - 0.0065 16.9 0.2 0.012 16.0 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T106641_2 - 0.15 11.6 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like GATase_7 PF13537.4 T383210_1 - 7.1e-10 38.7 0.0 1.1e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.4 T383210_1 - 2.6e-05 24.3 0.0 4.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain RNase_H PF00075.22 T294827_1 - 4.7e-22 78.6 0.0 7.6e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 RNase H rve PF00665.24 T294827_1 - 1e-09 38.5 0.0 1.8e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T294827_1 - 9e-08 32.1 0.1 2.6e-07 30.7 0.1 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger DUF1725 PF08333.9 T110422_3 - 4.5e-08 32.4 1.7 8.6e-08 31.5 1.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF3704 PF12488.6 T155660_2 - 0.091 12.3 7.8 0.023 14.2 4.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3704) PhoPQ_related PF10142.7 T155660_3 - 2e-16 59.5 0.0 3e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Coilin_N PF15862.3 T068779_1 - 0.00081 19.1 9.2 0.0013 18.4 9.2 1.2 1 0 0 1 1 1 1 Coilin N-terminus Eapp_C PF10238.7 T068779_1 - 0.066 13.2 3.6 0.13 12.2 3.6 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein DDHD PF02862.15 T068779_1 - 0.15 12.1 1.3 0.23 11.4 1.3 1.2 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.10 T068779_1 - 0.23 11.1 15.3 0.35 10.5 15.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.6 T068779_1 - 0.81 8.4 20.0 1.1 7.9 20.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Rrn6 PF10214.7 T068779_1 - 2 6.6 9.8 3 6.0 9.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1510 PF07423.9 T068779_1 - 3.1 7.0 16.5 5 6.4 16.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SpoIIP PF07454.9 T068779_1 - 3.2 7.0 8.0 5.2 6.3 8.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CCDC71L PF15374.4 T068779_1 - 3.6 6.6 12.6 5.3 6.1 12.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L FLO_LFY PF01698.14 T068779_1 - 5.8 5.9 10.0 8.8 5.3 10.0 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Tim54 PF11711.6 T068779_1 - 5.9 5.4 14.1 8.6 4.9 14.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AAA_11 PF13086.4 T068779_1 - 6 6.4 10.7 9 5.8 10.7 1.1 1 0 0 1 1 1 0 AAA domain Sec62 PF03839.14 T068779_1 - 7.8 5.8 17.8 13 5.1 17.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Transposase_22 PF02994.12 T279632_1 - 3.4e-16 59.0 0.4 2.9e-09 36.1 0.0 2.3 2 0 0 2 2 2 2 L1 transposable element Transposase_22 PF02994.12 T279632_2 - 1.9e-08 33.5 6.2 0.0014 17.4 0.0 3.2 3 0 0 3 3 3 3 L1 transposable element RVT_1 PF00078.25 T279632_2 - 7.4e-05 22.2 0.3 0.00012 21.5 0.3 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T279632_3 - 2.7e-32 111.9 7.2 3e-31 108.5 7.2 2.2 1 1 0 1 1 1 1 L1 transposable element Mit_proteolip PF08039.9 T001137_2 - 0.94 9.7 2.8 2.2 8.5 2.8 1.6 1 0 0 1 1 1 0 Mitochondrial proteolipid DUF1028 PF06267.10 T258997_3 - 5.4 6.6 6.6 10 5.7 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) Transposase_22 PF02994.12 T080936_3 - 3.1e-88 296.0 18.4 1.6e-87 293.7 18.4 1.9 1 1 0 1 1 1 1 L1 transposable element Adaptin_binding PF10199.7 T080936_3 - 0.037 14.5 3.6 0.096 13.2 3.6 1.7 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Sec3_C_2 PF15278.4 T080936_3 - 0.13 12.4 3.9 6.5 7.0 0.7 2.4 2 0 0 2 2 2 0 Sec3 exocyst complex subunit ArAE_2_N PF10337.7 T080936_3 - 0.21 10.5 2.4 0.3 9.9 2.4 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Syntaxin-6_N PF09177.9 T080936_3 - 0.23 11.9 9.7 0.2 12.1 6.0 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal XhlA PF10779.7 T080936_3 - 4.8 7.3 7.7 1.2 9.2 2.3 2.5 2 0 0 2 2 2 0 Haemolysin XhlA Transposase_1 PF01359.16 T313653_1 - 2.6e-22 78.3 0.3 5.5e-22 77.3 0.3 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) zinc-ribbon_6 PF10005.7 T089779_2 - 0.13 12.9 0.7 9.5 6.9 0.4 2.6 2 0 0 2 2 2 0 zinc-ribbon domain MIP-T3 PF10243.7 T280773_1 - 0.027 13.1 19.1 0.041 12.5 19.1 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DDHD PF02862.15 T280773_1 - 0.056 13.4 1.9 0.086 12.8 1.9 1.2 1 0 0 1 1 1 0 DDHD domain CTNNB1_binding PF08347.9 T280773_2 - 7.3 6.6 6.9 13 5.7 6.9 1.3 1 0 0 1 1 1 0 N-terminal CTNNB1 binding Eapp_C PF10238.7 T280773_2 - 7.8 6.4 8.9 18 5.3 8.9 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein MIP-T3 PF10243.7 T280773_3 - 0.00079 18.1 14.7 0.0011 17.6 14.7 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Atrophin-1 PF03154.13 T280773_3 - 0.0021 16.3 12.2 0.0031 15.8 12.2 1.2 1 0 0 1 1 1 1 Atrophin-1 family SpoIIP PF07454.9 T280773_3 - 0.063 12.6 2.5 0.1 11.9 2.5 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.12 T280773_3 - 0.25 9.4 6.8 0.35 9.0 6.8 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.12 T280773_3 - 1.3 9.3 9.8 2.8 8.2 9.8 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Eapp_C PF10238.7 T280773_3 - 1.9 8.4 12.0 3.9 7.4 12.0 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF4770 PF15994.3 T280773_3 - 2 8.5 9.9 4.9 7.2 9.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Peptidase_S49_N PF08496.8 T188421_3 - 5.4 6.9 5.6 9.8 6.1 5.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Fibrinogen_BP PF08017.9 T222931_1 - 3.8e-18 65.0 18.8 9.3e-09 34.1 0.2 3.1 3 0 0 3 3 3 3 Fibrinogen binding protein BRCA-2_helical PF09169.8 T222931_1 - 0.33 10.5 11.6 8.6 5.8 0.2 5.3 4 2 3 7 7 7 0 BRCA2, helical Fibrinogen_BP PF08017.9 T222931_2 - 6.4e-18 64.2 0.0 3.4e-11 42.1 0.1 3.0 3 0 0 3 3 3 2 Fibrinogen binding protein Mucin-like PF16058.3 T300744_2 - 0.027 14.4 5.9 0.057 13.4 5.9 1.5 1 0 0 1 1 1 0 Mucin-like Herpes_LMP1 PF05297.9 T300744_2 - 8.3 5.4 8.4 13 4.7 8.4 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Epiglycanin_C PF14654.4 T300744_3 - 4e-09 36.3 0.7 8.8e-09 35.2 0.7 1.6 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300744_3 - 2.4e-06 27.4 4.4 6e-06 26.1 4.4 1.6 1 0 0 1 1 1 1 Mucin-like Mit_proteolip PF08039.9 T001138_1 - 0.93 9.7 2.8 1.7 8.9 2.8 1.4 1 0 0 1 1 1 0 Mitochondrial proteolipid Trypsin PF00089.24 T338751_2 - 1.2e-08 35.0 0.0 2e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 T338751_2 - 0.0058 16.9 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) RST PF12174.6 T352788_1 - 1.6 8.7 24.0 56 3.7 0.0 12.4 15 3 2 17 17 17 0 RCD1-SRO-TAF4 (RST) plant domain RST PF12174.6 T352788_2 - 1.1 9.2 28.8 26 4.8 0.0 13.3 16 3 1 19 19 19 0 RCD1-SRO-TAF4 (RST) plant domain RST PF12174.6 T352788_3 - 0.014 15.2 21.8 26 4.8 0.0 12.1 13 1 0 14 14 14 0 RCD1-SRO-TAF4 (RST) plant domain Transposase_1 PF01359.16 T351160_2 - 0.05 13.3 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_1 PF01359.16 T351160_3 - 8.8e-21 73.4 7.1 1.8e-20 72.4 4.2 2.6 2 0 0 2 2 2 1 Transposase (partial DDE domain) BEN PF10523.7 T351160_3 - 0.072 13.2 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 BEN domain rve PF00665.24 T374059_2 - 5.1e-22 78.2 0.0 1.8e-21 76.4 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain RNase_H PF00075.22 T374059_2 - 3.3e-17 62.9 0.2 9.9e-17 61.3 0.0 1.8 2 0 0 2 2 2 1 RNase H RVT_1 PF00078.25 T374059_2 - 1.7e-09 37.4 0.0 2.8e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H3C2 PF16721.3 T374059_2 - 0.11 12.8 0.1 0.32 11.2 0.1 1.8 1 0 0 1 1 1 0 Zinc-finger like, probable DNA-binding TLV_coat PF00429.17 T374059_3 - 6.2e-40 137.3 8.2 7.1e-37 127.2 3.5 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) RVP PF00077.18 T374059_3 - 2.1e-10 40.6 0.0 3.9e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease DUF1725 PF08333.9 T268281_3 - 6e-05 22.4 1.8 0.00012 21.5 1.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T165140_3 - 2.5e-07 29.8 0.7 3.9e-07 29.1 0.7 1.2 1 0 0 1 1 1 1 L1 transposable element DUF2981 PF11200.6 T165140_3 - 3.9 6.4 10.0 18 4.3 3.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2981) Integrase_Zn PF02022.17 T127444_1 - 0.013 15.3 0.3 1 9.2 0.1 2.7 2 0 0 2 2 2 0 Integrase Zinc binding domain DUF331 PF03889.11 T291613_2 - 0.21 11.0 1.2 0.59 9.6 1.2 1.7 1 0 0 1 1 1 0 Domain of unknown function Ig_3 PF13927.4 T291613_3 - 0.016 15.6 0.0 0.15 12.6 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.14 T291613_3 - 0.11 12.4 0.0 0.33 10.9 0.0 1.7 2 0 0 2 2 2 0 Immunoglobulin I-set domain PNRC PF15365.4 T317176_3 - 0.95 10.0 5.3 24 5.5 0.2 2.9 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator CTD PF12815.5 T259458_1 - 4.4e-10 39.8 40.4 1.5e-06 28.6 17.7 5.9 5 2 1 6 6 6 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Mucin-like PF16058.3 T259458_2 - 3.1e-07 30.3 35.7 1.2e-05 25.2 10.4 7.8 4 2 3 8 8 8 3 Mucin-like CTD PF12815.5 T259458_3 - 3.4e-15 56.2 104.7 8.1e-07 29.4 16.0 5.2 3 1 4 7 7 7 5 Spt5 C-terminal nonapeptide repeat binding Spt4 Caskin1-CID PF16600.3 T259458_3 - 0.009 16.4 0.9 1.1e+02 3.3 0.0 5.3 5 0 0 5 5 5 0 Caskin1 CASK-interaction domain RVT_1 PF00078.25 T159805_2 - 0.054 12.9 0.0 0.092 12.1 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.18 T159805_3 - 0.036 14.2 0.0 0.072 13.2 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease KSR1-SAM PF13543.4 T018598_3 - 3.5e-06 27.0 0.6 5.7e-06 26.4 0.6 1.2 1 0 0 1 1 1 1 SAM like domain present in kinase suppressor RAS 1 PNMA PF14893.4 T177665_1 - 8.1e-45 153.5 0.0 1.1e-44 153.0 0.0 1.1 1 0 0 1 1 1 1 PNMA GAIN PF16489.3 T229024_1 - 1.3e-09 37.6 0.0 1.9e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Pentapeptide_4 PF13599.4 T384041_1 - 2.6e-37 126.7 4.9 0.74 9.9 0.0 25.5 25 6 5 30 30 30 14 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T384041_2 - 1.2e-42 143.8 71.4 0.0016 18.4 0.4 30.3 24 8 6 30 30 30 21 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T384041_3 - 3.9e-45 151.7 15.0 0.072 13.1 0.0 28.5 21 8 6 29 29 29 20 Pentapeptide repeats (9 copies) WAP PF00095.19 T073911_3 - 0.00028 21.1 11.8 0.0025 18.0 11.8 2.2 1 1 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' DUF1028 PF06267.10 T258993_2 - 4.9 6.8 6.6 10 5.7 6.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF1028) Ribosomal_L22e PF01776.15 T118808_3 - 0.0003 21.0 0.3 0.00047 20.4 0.3 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family Plasmodium_Vir PF05795.9 T305693_3 - 0.033 13.5 7.9 0.053 12.8 7.9 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein MRFAP1 PF15155.4 T260522_2 - 6.5e-56 187.9 14.0 1e-55 187.2 14.0 1.3 1 0 0 1 1 1 1 MORF4 family-associated protein1 B12D PF06522.9 T100637_3 - 2e-08 33.7 0.0 5.2e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit RVT_1 PF00078.25 T012480_1 - 1.6e-06 27.7 1.0 6.3e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T012480_2 - 1.1e-06 28.2 0.1 1.7e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T012480_3 - 1.9e-06 27.2 0.2 4.3e-06 26.1 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) MgtE_N PF03448.15 T164823_3 - 0.00077 19.9 0.0 0.0013 19.2 0.0 1.2 1 0 0 1 1 1 1 MgtE intracellular N domain RVT_1 PF00078.25 T279097_1 - 1.1e-27 96.9 0.4 1.7e-27 96.3 0.4 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T279097_3 - 9.9e-84 281.2 18.1 6.2e-78 262.1 8.2 2.3 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T279097_3 - 7.9e-11 41.8 0.2 1.3e-10 41.0 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T279097_3 - 0.0076 15.8 2.9 0.015 14.8 2.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) zf-H2C2 PF09337.8 T043677_3 - 0.00012 22.2 0.3 0.00024 21.2 0.3 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger DUF1725 PF08333.9 T227295_3 - 0.00075 19.0 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1777 PF08648.10 T245289_2 - 0.00032 20.8 0.6 0.00033 20.8 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) DUF3306 PF11748.6 T245289_2 - 0.004 17.9 1.3 0.0041 17.8 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3306) RNA_pol_Rpc4 PF05132.12 T245289_2 - 0.02 15.2 1.8 0.022 15.1 1.8 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 CPSF100_C PF13299.4 T245289_2 - 0.044 13.8 3.1 0.051 13.6 3.1 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.15 T245289_2 - 0.054 12.1 0.7 0.056 12.0 0.7 1.1 1 0 0 1 1 1 0 Presenilin Connexin PF00029.17 T245289_2 - 0.34 10.5 5.1 0.53 9.9 3.8 1.7 1 1 1 2 2 2 0 Connexin DUF913 PF06025.10 T245289_2 - 0.51 9.1 2.6 0.56 9.0 2.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Sigma70_ner PF04546.11 T245289_2 - 3.1 7.5 21.2 4.8 6.9 21.2 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.10 T245289_2 - 9.6 4.1 27.3 11 3.9 27.3 1.0 1 0 0 1 1 1 0 Nop14-like family Connexin PF00029.17 T245289_3 - 1.4e-06 28.1 3.5 1.7e-06 27.9 3.5 1.1 1 0 0 1 1 1 1 Connexin PcfK PF14058.4 T245289_3 - 5.4e-06 26.6 5.8 6.2e-06 26.4 5.8 1.2 1 0 0 1 1 1 1 PcfK-like protein Folate_carrier PF01770.16 T245289_3 - 0.00014 20.6 1.2 0.00016 20.4 1.2 1.1 1 0 0 1 1 1 1 Reduced folate carrier Afi1 PF07792.10 T245289_3 - 0.00015 22.1 0.6 0.0002 21.7 0.6 1.2 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking PIP5K PF01504.16 T245289_3 - 0.00016 20.9 4.5 0.0002 20.5 4.5 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase EOS1 PF12326.6 T245289_3 - 0.0018 18.1 1.3 0.0024 17.7 1.3 1.2 1 0 0 1 1 1 1 N-glycosylation protein FAM176 PF14851.4 T245289_3 - 0.0018 17.8 4.6 0.0036 16.8 4.6 1.4 1 0 0 1 1 1 1 FAM176 family Pex24p PF06398.9 T245289_3 - 0.0018 17.2 1.5 0.0019 17.1 1.5 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF1510 PF07423.9 T245289_3 - 0.0031 16.8 10.5 0.0043 16.4 10.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) DDHD PF02862.15 T245289_3 - 0.0063 16.6 1.0 0.0068 16.4 1.0 1.1 1 0 0 1 1 1 1 DDHD domain CLN3 PF02487.15 T245289_3 - 0.0078 15.2 0.2 0.0083 15.1 0.2 1.1 1 0 0 1 1 1 1 CLN3 protein RNA_pol_Rpc4 PF05132.12 T245289_3 - 0.0088 16.4 8.3 0.012 15.9 8.3 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 TerC PF03741.14 T245289_3 - 0.014 15.0 8.9 0.2 11.2 8.9 2.0 1 1 0 1 1 1 0 Integral membrane protein TerC family DUF913 PF06025.10 T245289_3 - 0.017 14.0 0.5 0.019 13.8 0.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FPN1 PF06963.10 T245289_3 - 0.018 13.5 0.9 0.023 13.2 0.9 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) NEMP PF10225.7 T245289_3 - 0.019 14.6 1.1 0.025 14.2 1.1 1.2 1 0 0 1 1 1 0 NEMP family CSG2 PF16965.3 T245289_3 - 0.033 13.0 2.8 0.05 12.4 2.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Neur_chan_memb PF02932.14 T245289_3 - 0.037 14.0 0.1 0.04 13.8 0.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HSP90 PF00183.16 T245289_3 - 0.048 12.4 14.3 0.058 12.1 14.3 1.0 1 0 0 1 1 1 0 Hsp90 protein AIF_C PF14721.4 T245289_3 - 0.05 13.8 5.7 0.064 13.5 5.7 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SpoIIP PF07454.9 T245289_3 - 0.051 12.9 10.5 0.062 12.6 10.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FHIPEP PF00771.18 T245289_3 - 0.11 10.8 0.3 0.14 10.5 0.3 1.1 1 0 0 1 1 1 0 FHIPEP family SLD3 PF08639.8 T245289_3 - 0.12 11.0 19.7 0.17 10.5 19.7 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 V_ATPase_I PF01496.17 T245289_3 - 0.12 10.1 11.0 0.16 9.7 11.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NARP1 PF12569.6 T245289_3 - 0.12 11.0 24.9 0.15 10.8 24.9 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Rxt3 PF08642.8 T245289_3 - 0.15 12.7 4.5 0.22 12.2 4.5 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 TFB6 PF17110.3 T245289_3 - 0.18 11.4 3.5 0.24 11.0 3.5 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH EIIBC-GUT_N PF03612.12 T245289_3 - 0.27 10.8 9.0 0.38 10.3 9.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Eapp_C PF10238.7 T245289_3 - 0.29 11.1 10.6 0.49 10.3 10.6 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF4366 PF14283.4 T245289_3 - 0.3 10.4 7.7 0.41 10.0 7.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Nucleo_P87 PF07267.9 T245289_3 - 0.4 9.4 10.3 0.47 9.1 10.3 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TRAP-gamma PF07074.10 T245289_3 - 0.45 9.9 8.7 0.56 9.6 8.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) DUF3188 PF11384.6 T245289_3 - 0.59 9.7 0.0 0.59 9.7 0.0 3.0 3 1 0 3 3 2 0 Protein of unknown function (DUF3188) Peroxin-13_N PF04088.11 T245289_3 - 0.94 9.6 8.9 1.3 9.2 8.9 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF4228 PF14009.4 T245289_3 - 1 9.7 6.7 1.3 9.3 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) GCD14 PF08704.8 T245289_3 - 1 8.9 4.8 1.2 8.7 4.8 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit MAP17 PF15807.3 T245289_3 - 1.2 9.2 12.9 2.3 8.3 12.9 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SpoVR PF04293.11 T245289_3 - 1.6 7.2 10.1 2.2 6.7 10.1 1.1 1 0 0 1 1 1 0 SpoVR like protein Serinc PF03348.13 T245289_3 - 1.8 7.3 7.6 2.6 6.8 7.6 1.3 1 1 0 1 1 1 0 Serine incorporator (Serinc) RNase_H2-Ydr279 PF09468.8 T245289_3 - 1.9 7.8 25.2 2.8 7.3 25.2 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Cas_Csy4 PF09618.8 T245289_3 - 2 8.4 10.3 2.5 8.1 10.3 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) DUF2828 PF11443.6 T245289_3 - 2.3 6.1 13.7 2.8 5.8 13.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Tim54 PF11711.6 T245289_3 - 2.8 6.5 17.0 3.7 6.1 17.0 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF1682 PF07946.12 T245289_3 - 3 6.8 30.9 0.66 9.0 27.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) Coilin_N PF15862.3 T245289_3 - 4.2 7.0 28.7 6.3 6.5 28.7 1.3 1 0 0 1 1 1 0 Coilin N-terminus GNAT_acetyltr_2 PF13718.4 T245289_3 - 4.7 6.4 9.2 6.1 6.0 9.2 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 AAA_23 PF13476.4 T245289_3 - 6.3 7.1 22.2 8.8 6.6 22.2 1.1 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.4 T245289_3 - 7.9 6.0 14.8 10 5.6 14.8 1.1 1 0 0 1 1 1 0 AAA domain Epiglycanin_C PF14654.4 T300739_1 - 3.7e-09 36.4 0.7 7.3e-09 35.5 0.7 1.5 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300739_1 - 2.3e-06 27.5 4.4 4.9e-06 26.4 4.4 1.5 1 0 0 1 1 1 1 Mucin-like Mucin-like PF16058.3 T300739_3 - 0.012 15.5 5.1 0.026 14.5 5.1 1.6 1 0 0 1 1 1 0 Mucin-like Herpes_LMP1 PF05297.9 T300739_3 - 6.7 5.7 8.3 10 5.1 8.3 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF1725 PF08333.9 T110427_1 - 1.4e-08 34.0 0.8 3.6e-08 32.7 0.8 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_1 PF01359.16 T351159_1 - 8.7e-21 73.5 7.1 1.8e-20 72.4 4.2 2.6 2 0 0 2 2 2 1 Transposase (partial DDE domain) BEN PF10523.7 T351159_1 - 0.094 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 BEN domain Transposase_1 PF01359.16 T351159_3 - 0.049 13.4 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_22 PF02994.12 T280436_1 - 4.5e-98 328.4 23.5 1e-96 323.8 23.5 2.1 1 1 0 1 1 1 1 L1 transposable element DUF1725 PF08333.9 T280436_1 - 0.00031 20.2 0.2 0.00068 19.1 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T280436_2 - 2.9e-36 124.9 2.6 4.6e-36 124.3 2.6 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4391 PF14335.4 T280436_3 - 0.0054 16.3 7.8 0.0093 15.6 7.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4391) Fer4_19 PF06902.9 T126495_1 - 0.091 12.7 2.0 26 4.9 0.0 3.8 4 0 0 4 4 4 0 Divergent 4Fe-4S mono-cluster CTD PF12815.5 T259454_1 - 1.2e-10 41.7 48.0 1.2e-06 28.8 17.2 4.1 1 1 1 2 2 2 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Mucin-like PF16058.3 T259454_2 - 5.3e-07 29.5 35.7 1.3e-05 25.0 10.3 9.4 6 1 5 11 11 11 3 Mucin-like CTD PF12815.5 T259454_3 - 3.2e-15 56.3 102.0 9.8e-07 29.1 16.0 4.8 3 1 4 7 7 7 5 Spt5 C-terminal nonapeptide repeat binding Spt4 RNA_pol_3_Rpc31 PF11705.6 T027756_1 - 7.9e-06 26.1 19.1 1.3e-05 25.5 19.1 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Paf1 PF03985.11 T027756_1 - 0.12 11.2 17.0 0.68 8.7 18.3 1.5 2 0 0 2 2 2 0 Paf1 FAM176 PF14851.4 T027756_1 - 0.14 11.7 8.2 0.26 10.9 8.2 1.3 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.10 T027756_1 - 0.16 11.2 12.3 0.25 10.6 12.3 1.1 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.9 T027756_1 - 0.27 11.1 7.5 0.47 10.3 7.5 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.10 T027756_1 - 0.43 8.6 14.1 0.59 8.2 14.1 1.0 1 0 0 1 1 1 0 Nop14-like family AIM3 PF17096.3 T027756_1 - 0.53 11.1 3.0 1.1 10.1 3.0 1.4 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 PPP4R2 PF09184.9 T027756_1 - 0.54 9.7 14.6 0.8 9.1 14.6 1.2 1 0 0 1 1 1 0 PPP4R2 CDC27 PF09507.8 T027756_1 - 0.6 9.3 13.8 0.83 8.8 13.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF1510 PF07423.9 T027756_1 - 0.64 9.3 15.8 0.99 8.7 15.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Pox_Ag35 PF03286.12 T027756_1 - 0.78 9.4 14.3 1.2 8.7 14.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Vfa1 PF08432.8 T027756_1 - 1 9.5 9.8 1.7 8.8 9.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1840 PF08895.9 T027756_1 - 1.5 9.1 5.7 2.8 8.2 5.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) DUF913 PF06025.10 T027756_1 - 1.9 7.2 3.9 2.8 6.7 3.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4746 PF15928.3 T027756_1 - 2.4 7.3 19.3 3.6 6.8 19.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) AIF_C PF14721.4 T027756_1 - 3.2 8.0 5.8 5.3 7.3 5.8 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RR_TM4-6 PF06459.10 T027756_1 - 3.3 7.3 12.3 5.1 6.7 12.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NPR3 PF03666.11 T027756_1 - 3.3 6.3 5.9 4.7 5.7 5.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DDRGK PF09756.7 T027756_1 - 4 6.9 25.7 5.7 6.4 25.7 1.2 1 0 0 1 1 1 0 DDRGK domain Atrophin-1 PF03154.13 T333527_2 - 0.19 9.9 25.2 0.33 9.0 25.2 1.3 1 0 0 1 1 1 0 Atrophin-1 family Cyt-b5 PF00173.26 T058837_3 - 1.3e-12 47.5 0.0 2.3e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.22 T058837_3 - 5.4e-06 26.3 2.0 8e-06 25.7 2.0 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Colipase-like PF15083.4 T090337_1 - 1.8e-45 152.9 26.6 5e-38 129.0 13.6 2.6 1 1 1 2 2 2 2 Colipase-like DEC-1_N PF04625.11 T324408_2 - 0.024 13.5 1.1 0.11 11.4 0.2 2.1 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region SpoIIP PF07454.9 T214657_1 - 0.00019 20.9 0.7 0.00025 20.5 0.7 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) DUF1777 PF08648.10 T214657_1 - 0.00031 20.9 7.7 0.00041 20.5 7.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) DDHD PF02862.15 T214657_1 - 0.029 14.3 0.4 0.036 14.1 0.4 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.15 T214657_1 - 0.23 10.0 7.6 0.3 9.7 7.6 1.1 1 0 0 1 1 1 0 Presenilin DUF4820 PF16091.3 T214657_1 - 0.24 10.6 13.3 0.35 10.1 13.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) BUD22 PF09073.8 T214657_1 - 0.61 9.2 26.7 0.86 8.7 26.7 1.1 1 0 0 1 1 1 0 BUD22 NPR3 PF03666.11 T214657_1 - 1 7.9 19.4 1.5 7.4 19.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FAM176 PF14851.4 T214657_1 - 1.2 8.7 17.1 2.2 7.8 17.1 1.3 1 0 0 1 1 1 0 FAM176 family Myc_N PF01056.16 T214657_1 - 1.6 8.3 12.5 2.8 7.6 12.5 1.3 1 0 0 1 1 1 0 Myc amino-terminal region DUF913 PF06025.10 T214657_1 - 1.7 7.4 10.5 2.3 6.9 10.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SR-25 PF10500.7 T214657_1 - 1.7 8.1 27.0 2.4 7.5 27.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FYDLN_acid PF09538.8 T214657_1 - 2.6 8.7 18.0 4.4 7.9 18.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Eapp_C PF10238.7 T214657_1 - 9.9 6.1 16.1 19 5.2 16.1 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF1725 PF08333.9 T214657_2 - 2.5e-09 36.4 0.8 5e-09 35.4 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Eapp_C PF10238.7 T214657_2 - 0.32 10.9 5.6 0.54 10.2 5.6 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Peptidase_S49_N PF08496.8 T214657_2 - 0.58 10.1 13.3 1.2 9.1 13.3 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PEHE PF15275.4 T214657_2 - 0.65 10.5 11.3 1.1 9.7 11.3 1.3 1 0 0 1 1 1 0 PEHE domain RR_TM4-6 PF06459.10 T214657_2 - 2.1 8.0 7.9 3 7.5 7.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF755 PF05501.9 T214657_3 - 0.07 13.3 13.7 0.12 12.5 13.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Rrn6 PF10214.7 T214657_3 - 0.21 9.8 15.8 0.29 9.4 15.8 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CDC45 PF02724.12 T214657_3 - 3.3 5.8 18.6 4.6 5.3 18.6 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3381 PF11861.6 T214657_3 - 3.4 7.3 18.2 5.5 6.7 18.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) TFIIF_alpha PF05793.10 T214657_3 - 7.3 4.9 17.0 9.9 4.5 17.0 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Transposase_1 PF01359.16 T330240_1 - 1.7e-18 66.1 0.0 3.6e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T330240_2 - 0.0033 17.1 1.9 0.0033 17.1 1.9 2.0 2 0 0 2 2 2 1 Transposase (partial DDE domain) Gag_p24 PF00607.18 T274837_1 - 1e-26 94.0 0.0 1.5e-26 93.4 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) dUTPase PF00692.17 T274837_1 - 1.4e-19 69.9 0.0 3.7e-18 65.3 0.0 2.2 2 0 0 2 2 2 1 dUTPase Transposase_22 PF02994.12 T274837_1 - 3e-06 26.2 3.8 4.2e-06 25.7 3.8 1.1 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T274837_1 - 8.5e-05 22.0 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_5 PF14787.4 T274837_2 - 2.2e-06 27.1 19.1 5.2e-06 25.9 8.7 3.2 2 1 0 2 2 2 2 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.21 T274837_2 - 0.00073 19.4 6.8 0.0045 16.9 6.2 2.9 2 0 0 2 2 2 1 Zinc knuckle RNase_H PF00075.22 T274837_2 - 0.046 13.8 0.0 0.075 13.1 0.0 1.3 1 0 0 1 1 1 0 RNase H RVT_1 PF00078.25 T274837_3 - 1.1e-24 87.0 0.3 3.4e-13 49.5 0.1 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.12 T274837_3 - 1.7e-24 85.2 0.6 4.2e-24 83.9 0.6 1.7 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVP PF00077.18 T274837_3 - 2e-20 72.8 0.0 4.5e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T274837_3 - 2.2e-18 66.5 0.0 4.1e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Gag_p10 PF02337.15 T274837_3 - 4.9e-14 51.8 0.2 1.1e-13 50.7 0.2 1.6 1 0 0 1 1 1 1 Retroviral GAG p10 protein Gag_p24 PF00607.18 T274837_3 - 2.4e-12 47.0 0.2 4.8e-12 46.0 0.2 1.5 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) GP41 PF00517.15 T274837_3 - 2.8e-12 46.8 0.5 5.2e-12 45.9 0.5 1.4 1 0 0 1 1 1 1 Retroviral envelope protein RNase_H PF00075.22 T274837_3 - 8.5e-11 42.1 0.1 8.5e-11 42.1 0.1 1.6 2 0 0 2 2 1 1 RNase H G-patch PF01585.21 T274837_3 - 1e-08 34.8 2.2 2.1e-08 33.8 2.2 1.5 1 0 0 1 1 1 1 G-patch domain Integrase_Zn PF02022.17 T274837_3 - 0.00086 19.1 1.5 0.0028 17.4 1.5 2.0 1 0 0 1 1 1 1 Integrase Zinc binding domain IN_DBD_C PF00552.19 T274837_3 - 0.0028 16.8 3.1 0.0062 15.7 3.1 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain Transposase_22 PF02994.12 T064373_1 - 2.3e-22 79.2 0.5 3.6e-22 78.6 0.5 1.1 1 0 0 1 1 1 1 L1 transposable element TMEM191C PF15194.4 T230000_1 - 2.8e-12 46.7 0.0 7.9e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 TMEM191C family ATG16 PF08614.9 T230000_1 - 1.7 8.7 15.3 4.1 7.4 1.7 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) ADIP PF11559.6 T230000_1 - 3.8 7.5 15.6 3.1 7.8 1.4 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ExsD PF16806.3 T230000_1 - 9.1 6.0 9.1 21 4.8 9.1 1.5 1 0 0 1 1 1 0 Antiactivator protein ExsD TMEM191C PF15194.4 T230000_2 - 9.9e-27 93.3 8.7 9.9e-27 93.3 8.7 1.6 2 0 0 2 2 2 1 TMEM191C family Cornifin PF02389.13 T368567_2 - 2e-11 44.1 34.4 1.3e-07 31.8 8.6 3.7 2 1 2 4 4 4 3 Cornifin (SPRR) family RNase_H PF00075.22 T172332_1 - 1.2e-16 61.0 0.0 2.2e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-H2C2 PF09337.8 T172332_1 - 4.4e-05 23.6 0.3 0.00011 22.3 0.3 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RNase_H PF00075.22 T201647_1 - 2.4e-20 73.0 0.0 4.5e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 RNase H rve PF00665.24 T201647_1 - 3.2e-06 27.2 0.0 6.5e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.4 T201647_1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain zf-H2C2 PF09337.8 T201647_2 - 3.1e-06 27.2 1.8 5.1e-06 26.5 1.8 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Filament PF00038.19 T078925_1 - 1.1e-40 140.0 14.0 1.5e-40 139.6 14.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein BRE1 PF08647.9 T078925_1 - 0.22 11.5 10.0 0.56 10.2 2.9 2.4 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase MscS_porin PF12795.5 T078925_1 - 0.38 10.1 10.2 0.68 9.3 10.2 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain CALCOCO1 PF07888.9 T078925_1 - 0.39 9.1 11.7 0.54 8.6 11.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.9 T078925_1 - 1.4 7.6 12.0 2.8 6.6 11.8 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.5 T078925_1 - 2.7 8.0 12.9 4.4 7.3 12.9 1.2 1 0 0 1 1 1 0 Tropomyosin like Muted PF14942.4 T078925_1 - 3.5 7.8 10.2 5.3 7.2 10.2 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Filament PF00038.19 T078925_2 - 0.0025 17.3 0.0 0.0031 17.0 0.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein DUF3060 PF11259.6 T051123_1 - 1.4e-05 24.6 0.0 5.7 6.6 0.0 4.2 2 1 2 4 4 4 4 Protein of unknown function (DUF3060) DUF296 PF03479.13 T051123_1 - 0.19 12.1 6.4 7.7e+02 0.6 6.4 4.0 1 1 0 1 1 1 0 Domain of unknown function (DUF296) Peptidase_S49_N PF08496.8 T188424_2 - 5.8 6.9 5.6 11 6.0 5.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TLV_coat PF00429.17 T290884_2 - 0.00026 19.7 3.2 0.0024 16.5 0.0 2.7 3 0 0 3 3 3 2 ENV polyprotein (coat polyprotein) Tim54 PF11711.6 T091424_1 - 0.028 13.1 6.6 0.041 12.5 6.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2011 PF09428.8 T091424_1 - 5.9 6.7 23.9 9.9 6.0 23.9 1.2 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) RNA_polI_A34 PF08208.9 T091424_1 - 5.9 6.8 21.7 9.6 6.1 21.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF2058 PF09831.7 T091424_1 - 9.4 6.2 14.7 15 5.5 14.7 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) AP3D1 PF06375.9 T091424_2 - 0.74 9.9 17.0 1.6 8.9 17.0 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Colipase-like PF15083.4 T090335_2 - 1.8e-32 111.2 10.9 3.4e-32 110.3 10.9 1.4 1 0 0 1 1 1 1 Colipase-like Colipase-like PF15083.4 T090335_3 - 2.4e-11 43.5 2.3 5.5e-11 42.3 2.3 1.5 1 0 0 1 1 1 1 Colipase-like DUF4705 PF15788.3 T323198_1 - 3.6e-48 161.4 550.3 1.5e-15 57.0 9.2 47.5 29 11 14 43 43 43 24 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323198_2 - 2.6e-72 238.7 527.4 4e-17 62.0 8.0 46.7 26 17 21 47 47 47 28 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323198_3 - 3.6e-62 206.2 532.5 4.1e-08 33.2 4.4 49.9 31 10 15 47 47 47 35 Domain of unknown function (DUF4705) DUF3809 PF12723.5 T182957_3 - 0.027 14.6 0.2 3.2e+02 1.4 0.0 5.7 3 3 5 8 8 8 0 Protein of unknown function (DUF3809) Myb_DNA-bind_4 PF13837.4 T294744_2 - 4.8e-06 26.8 0.2 6.7e-06 26.3 0.2 1.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF1048 PF06304.9 T294744_2 - 0.0028 17.9 0.0 1.9 8.8 0.3 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1048) tRNA_NucTran2_2 PF13735.4 T294744_2 - 0.06 13.2 0.3 0.091 12.6 0.3 1.2 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative Colipase-like PF15083.4 T090316_3 - 2.6e-32 110.7 11.3 2.6e-32 110.7 11.3 1.8 2 0 0 2 2 2 1 Colipase-like DDHD PF02862.15 T002762_2 - 0.0015 18.6 6.8 0.0043 17.1 0.8 2.2 2 0 0 2 2 2 2 DDHD domain TFIIA PF03153.11 T002762_2 - 0.051 13.4 12.1 0.087 12.7 12.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNA_pol_Rpc4 PF05132.12 T002762_2 - 1.9 8.8 24.2 0.69 10.2 2.9 2.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 Yae1_N PF09811.7 T002762_3 - 0.57 9.8 4.1 1.3 8.6 4.1 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal CTD PF12815.5 T353408_2 - 0.9 10.0 7.3 51 4.4 1.2 4.3 1 1 1 2 2 2 0 Spt5 C-terminal nonapeptide repeat binding Spt4 ADAM_CR PF08516.10 T106638_3 - 7.1e-22 77.9 2.8 7.1e-22 77.9 2.8 3.4 2 1 1 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 T106638_3 - 3.2e-09 37.3 10.1 3.2e-09 37.3 10.1 3.3 3 0 0 3 3 3 1 Disintegrin DUF1725 PF08333.9 T110426_1 - 1.2e-08 34.2 0.8 3e-08 32.9 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) GTF2I PF02946.12 T000076_3 - 2.1e-07 30.7 0.0 3.6e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 GTF2I-like repeat Mucin-like PF16058.3 T099174_3 - 0.0003 20.7 2.8 0.0024 17.8 0.6 2.4 1 1 1 2 2 2 2 Mucin-like RVT_thumb PF06817.12 T338205_1 - 2.2e-28 97.6 0.1 5e-28 96.5 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVT_1 PF00078.25 T338205_1 - 1.7e-23 83.2 0.0 2.3e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GP41 PF00517.15 T338205_1 - 3.7e-14 52.9 0.3 7.2e-14 52.0 0.3 1.3 1 0 0 1 1 1 1 Retroviral envelope protein Gag_p10 PF02337.15 T338205_1 - 8e-07 28.7 0.2 1.8e-06 27.5 0.2 1.6 1 0 0 1 1 1 1 Retroviral GAG p10 protein Gag_p24 PF00607.18 T338205_2 - 4.9e-09 36.2 0.2 6.8e-09 35.8 0.2 1.1 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) IN_DBD_C PF00552.19 T338205_2 - 3.8e-06 26.0 0.0 8.3e-06 24.9 0.0 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain HERV-K_env_2 PF13804.4 T338205_3 - 3.4e-35 121.2 0.0 6.5e-35 120.2 0.0 1.4 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein RNase_H PF00075.22 T338205_3 - 7.8e-05 22.8 0.0 0.00012 22.1 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-CCHC PF00098.21 T176526_2 - 4.1e-06 26.5 2.6 1.4e-05 24.8 2.6 2.0 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.18 T176526_2 - 0.0015 18.6 0.0 0.003 17.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_1 PF00078.25 T176526_2 - 0.01 15.2 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T176526_3 - 0.0016 17.8 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p30 PF02093.14 T226525_1 - 9.1e-13 48.1 0.0 1.4e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RNase_H PF00075.22 T226525_1 - 9e-09 35.5 0.4 1.6e-08 34.7 0.4 1.4 1 0 0 1 1 1 1 RNase H rve PF00665.24 T226525_1 - 0.029 14.4 0.1 0.058 13.5 0.1 1.4 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.25 T226525_2 - 0.021 14.2 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T379145_1 - 1.6e-20 73.4 0.0 2.4e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Asp_protease_2 PF13650.4 T379145_1 - 0.011 16.3 0.0 0.02 15.4 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T379145_1 - 0.025 15.0 0.0 0.043 14.2 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_5 PF14787.4 T379145_1 - 0.029 14.0 16.9 0.22 11.1 6.3 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.21 T379145_1 - 0.042 13.8 12.8 0.052 13.5 6.1 2.9 2 0 0 2 2 2 0 Zinc knuckle RVP PF00077.18 T379145_1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease RVP PF00077.18 T068141_2 - 1e-06 28.8 0.0 2e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Gag_p30 PF02093.14 T068141_2 - 0.0068 15.8 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p30 PF02093.14 T297831_3 - 0.00033 20.1 0.0 0.00055 19.4 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T297831_3 - 0.0091 15.4 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T263099_3 - 2.9e-06 26.6 0.4 1.6e-05 24.2 0.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) RNase_H PF00075.22 T089157_2 - 6.8e-15 55.4 0.1 1.1e-14 54.7 0.1 1.3 1 0 0 1 1 1 1 RNase H TLV_coat PF00429.17 T089157_2 - 2.5e-12 46.1 0.3 2.5e-12 46.1 0.3 1.9 2 0 0 2 2 2 1 ENV polyprotein (coat polyprotein) Gag_p30 PF02093.14 T089157_3 - 2.9e-14 53.0 0.0 4.4e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T089157_3 - 4.3e-07 29.5 0.0 7.7e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T089157_3 - 8.7e-06 25.5 1.0 2.2e-05 24.2 1.0 1.8 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.18 T089157_3 - 0.00049 20.2 0.0 0.0009 19.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_5 PF14787.4 T089157_3 - 0.057 13.0 2.7 0.12 12.0 2.7 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Transposase_22 PF02994.12 T012229_1 - 3.7e-26 91.7 16.9 1.2e-19 70.3 0.0 3.7 4 0 0 4 4 4 3 L1 transposable element Transposase_22 PF02994.12 T012229_2 - 2e-26 92.6 6.6 5.7e-25 87.8 2.1 2.6 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T012229_2 - 0.02 14.4 0.3 0.045 13.3 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T012229_3 - 2.9e-38 131.5 1.9 2.4e-29 102.3 0.3 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RBP_receptor PF14752.4 T358366_1 - 1.1e-39 136.4 1.7 1.6e-39 135.9 1.7 1.1 1 0 0 1 1 1 1 Retinol binding protein receptor Transposase_1 PF01359.16 T361167_1 - 6.3e-27 93.1 0.2 1.5e-26 91.9 0.2 1.7 1 0 0 1 1 1 1 Transposase (partial DDE domain) HTH_32 PF13565.4 T361167_1 - 0.0004 20.8 0.0 0.00073 20.0 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.16 T361167_1 - 0.0031 17.6 0.0 0.005 16.9 0.0 1.3 1 0 0 1 1 1 1 Transposase HTH_24 PF13412.4 T361167_1 - 0.0057 16.1 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_23 PF13384.4 T361167_1 - 0.0068 16.0 0.1 0.37 10.5 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_11 PF08279.10 T361167_1 - 0.016 15.0 0.1 0.038 13.8 0.1 1.6 1 0 0 1 1 1 0 HTH domain HTH_28 PF13518.4 T361167_1 - 0.017 15.1 0.0 2.3 8.3 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain MarR_2 PF12802.5 T361167_1 - 0.023 14.4 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 MarR family DDE_3 PF13358.4 T361167_1 - 0.028 14.1 0.1 0.055 13.1 0.1 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_17 PF12728.5 T361167_1 - 0.078 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3439 PF11921.6 T364254_2 - 0.015 15.1 4.2 0.026 14.4 4.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF2256 PF10013.7 T364254_2 - 2.3 8.3 4.6 0.53 10.3 0.3 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF4705 PF15788.3 T323216_1 - 1e-93 307.3 466.4 3.2e-17 62.3 8.0 41.8 23 13 16 39 39 39 30 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323216_2 - 7.4e-64 211.6 462.1 1.2e-15 57.3 9.2 40.7 26 10 10 37 37 37 26 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323216_3 - 6.2e-19 67.8 61.9 1.5e-11 44.2 11.0 38.5 19 11 14 34 34 34 17 Domain of unknown function (DUF4705) rve PF00665.24 T069161_1 - 3.2e-21 75.6 0.0 6e-21 74.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T069161_1 - 1.1e-20 74.1 0.0 1.6e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 RNase H TLV_coat PF00429.17 T069161_1 - 4.1e-16 58.6 3.4 6.2e-16 58.1 3.4 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RVP PF00077.18 T069161_1 - 0.00052 20.1 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_3 PF13456.4 T069161_1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like TLV_coat PF00429.17 T069161_2 - 3.6e-21 75.3 9.0 4.4e-16 58.6 3.0 2.2 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) RVT_1 PF00078.25 T069161_3 - 2.2e-11 43.6 0.1 3.7e-11 42.8 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T016101_2 - 8.8e-07 28.3 2.1 6.9e-05 22.2 1.3 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1725) COG5 PF10392.7 T016101_3 - 0.07 13.2 0.2 0.13 12.3 0.2 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Thymosin PF01290.18 T342381_1 - 2.7e-05 23.6 0.1 5.6e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 Thymosin beta-4 family UPAR_LY6 PF00021.19 T353216_1 - 4e-06 27.3 6.1 7.5e-06 26.4 6.1 1.5 1 0 0 1 1 1 1 u-PAR/Ly-6 domain rve PF00665.24 T374587_2 - 6.8e-12 45.5 0.0 1.1e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain TLV_coat PF00429.17 T374587_3 - 1.9e-07 30.1 3.7 0.0026 16.4 2.5 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) Methyltransf_6 PF03737.13 T374587_3 - 0.045 13.8 0.0 0.075 13.1 0.0 1.2 1 0 0 1 1 1 0 Demethylmenaquinone methyltransferase DUF4705 PF15788.3 T323208_1 - 1.1e-71 236.7 504.4 3.6e-08 33.4 4.4 48.1 29 9 13 42 42 42 34 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323208_2 - 1.7e-58 194.5 514.4 1.3e-15 57.2 9.2 45.4 26 11 13 39 39 39 24 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323208_3 - 3.7e-81 267.0 488.8 3.5e-17 62.2 8.0 43.9 24 16 19 43 43 43 28 Domain of unknown function (DUF4705) SelP_N PF04592.12 T184391_1 - 1.1 8.5 12.3 1.8 7.8 12.3 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region GFO_IDH_MocA_C PF02894.15 T001696_3 - 0.13 12.1 0.0 0.39 10.6 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain RBP_receptor PF14752.4 T358358_3 - 3.1e-24 85.4 0.0 5.2e-24 84.7 0.0 1.3 1 0 0 1 1 1 1 Retinol binding protein receptor Hexapep PF00132.22 T359868_1 - 0.025 14.2 0.1 3.1 7.6 0.0 3.7 3 0 0 3 3 3 0 Bacterial transferase hexapeptide (six repeats) RVT_1 PF00078.25 T359868_2 - 0.0017 17.7 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Hexapep PF00132.22 T359868_2 - 0.025 14.1 0.1 66 3.3 0.0 4.8 4 1 0 4 4 4 0 Bacterial transferase hexapeptide (six repeats) Hexapep PF00132.22 T359868_3 - 0.062 12.9 0.0 16 5.2 0.0 3.3 3 0 0 3 3 3 0 Bacterial transferase hexapeptide (six repeats) MIP-T3 PF10243.7 T137316_1 - 0.39 9.3 20.9 0.49 8.9 20.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 MIP-T3 PF10243.7 T137316_2 - 4.2 5.8 31.9 5.2 5.5 31.9 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Raffinose_syn PF05691.10 T276645_2 - 0.034 11.8 0.8 8.2 3.9 0.0 3.9 4 1 0 5 5 5 0 Raffinose synthase or seed imbibition protein Sip1 Raffinose_syn PF05691.10 T276645_3 - 0.0021 15.8 0.3 3 5.4 0.0 3.9 4 0 0 4 4 4 2 Raffinose synthase or seed imbibition protein Sip1 DUF759 PF05537.9 T276645_3 - 0.0028 16.5 0.1 13 4.4 0.0 4.7 5 0 0 5 5 5 2 Borrelia burgdorferi protein of unknown function (DUF759) DUF4366 PF14283.4 T022834_2 - 0.38 10.1 2.6 0.7 9.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Wbp11 PF09429.8 T094010_1 - 0.092 13.0 8.7 0.19 12.0 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 Arylesterase PF01731.18 T381532_3 - 0.054 13.6 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Arylesterase CTD PF12815.5 T259457_1 - 3.3e-10 40.2 40.0 1.2e-06 28.8 17.5 4.3 3 1 1 4 4 4 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Caskin1-CID PF16600.3 T259457_1 - 0.0094 16.4 0.9 1.1e+02 3.3 0.0 5.3 5 0 0 5 5 5 0 Caskin1 CASK-interaction domain CTD PF12815.5 T259457_3 - 3.3e-15 56.3 104.7 8.1e-07 29.4 16.0 5.0 3 1 4 7 7 7 5 Spt5 C-terminal nonapeptide repeat binding Spt4 Orn_DAP_Arg_deC PF00278.20 T007024_1 - 5.5e-11 42.4 0.0 9.4e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Orn_Arg_deC_N PF02784.14 T007024_2 - 4e-05 23.1 0.0 5.6e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain GRP PF07172.9 T046677_1 - 2 9.0 26.8 3.1 8.4 26.8 1.3 1 0 0 1 1 1 0 Glycine rich protein family FoP_duplication PF13865.4 T046677_1 - 2.8 8.4 16.6 4.6 7.7 16.6 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 SpoIIP PF07454.9 T046677_2 - 0.021 14.2 1.7 0.026 13.9 1.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SDA1 PF05285.10 T046677_2 - 0.046 13.0 12.7 0.058 12.7 12.7 1.1 1 0 0 1 1 1 0 SDA1 PIEZO PF15917.3 T046677_2 - 0.12 11.7 4.1 0.17 11.1 4.1 1.1 1 0 0 1 1 1 0 Piezo DUF2457 PF10446.7 T046677_2 - 0.21 10.6 15.6 0.25 10.3 15.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Presenilin PF01080.15 T046677_2 - 0.38 9.3 2.4 0.55 8.8 2.4 1.2 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.4 T046677_2 - 0.89 9.1 11.5 1.5 8.4 11.5 1.3 1 0 0 1 1 1 0 FAM176 family DUF4820 PF16091.3 T046677_2 - 1.1 8.4 8.8 1.7 7.8 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF913 PF06025.10 T046677_2 - 2.3 7.0 5.4 2.9 6.6 5.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TRAP_alpha PF03896.14 T046677_2 - 4.8 6.2 12.0 6.4 5.7 12.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PTPRCAP PF15713.3 T046677_2 - 6.8 6.8 21.5 9 6.4 21.5 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CPSF100_C PF13299.4 T046677_2 - 7.4 6.6 8.7 9.8 6.2 8.7 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CDC45 PF02724.12 T046677_2 - 8.2 4.5 15.0 11 4.1 15.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Transposase_1 PF01359.16 T066578_1 - 4.8e-23 80.7 0.0 1.1e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) COX17 PF05051.11 T316022_1 - 2.1 8.6 5.9 2.7 8.3 3.4 2.3 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) DUF3923 PF13061.4 T139104_2 - 7.1e-08 32.3 79.8 9 6.3 1.9 17.5 1 1 16 18 18 18 14 Protein of unknown function (DUF3923) SpoIIE PF07228.10 T139104_2 - 9.1 6.0 9.8 1.3e+02 2.2 0.1 5.3 2 2 1 4 4 4 0 Stage II sporulation protein E (SpoIIE) CagY_M PF07337.9 T051671_1 - 2e-07 30.4 7.0 61 3.2 0.0 9.4 10 0 0 10 10 10 7 DC-EC Repeat CagY_M PF07337.9 T051671_2 - 1e-07 31.3 20.3 72 3.0 0.4 13.1 11 3 2 13 13 13 1 DC-EC Repeat ANATO PF01821.16 T051671_2 - 0.078 13.7 10.8 78 4.1 0.1 6.8 7 2 1 8 8 8 0 Anaphylotoxin-like domain CagY_M PF07337.9 T051671_3 - 3.1e-12 45.8 3.5 12 5.5 0.0 11.4 12 0 0 12 12 12 2 DC-EC Repeat SBP_bac_10 PF07596.9 T051671_3 - 5.3 6.8 72.2 2.3 8.0 0.6 9.9 1 1 2 4 4 4 0 Protein of unknown function (DUF1559) RS4NT PF08071.10 T194258_2 - 1.6 8.8 28.7 41 4.3 0.1 9.2 10 0 0 10 10 10 0 RS4NT (NUC023) domain CNDH2_C PF16858.3 T033518_1 - 0.00011 22.1 5.0 0.00017 21.5 5.0 1.1 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term FYDLN_acid PF09538.8 T033518_1 - 0.00093 19.7 21.7 0.00093 19.7 21.7 1.5 2 0 0 2 2 1 1 Protein of unknown function (FYDLN_acid) Mpp10 PF04006.10 T033518_1 - 0.076 11.3 20.0 0.11 10.8 20.0 1.1 1 0 0 1 1 1 0 Mpp10 protein RXT2_N PF08595.9 T033518_1 - 0.17 11.8 17.8 0.38 10.6 17.8 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal CSRNP_N PF16019.3 T033518_1 - 0.17 11.6 10.6 0.28 10.9 10.6 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Cwf_Cwc_15 PF04889.10 T033518_1 - 0.3 10.7 29.0 0.5 9.9 29.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.11 T033518_1 - 0.52 8.2 32.8 0.73 7.8 32.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.10 T033518_1 - 0.53 9.5 23.7 0.89 8.7 23.7 1.2 1 0 0 1 1 1 0 NOA36 protein BUD22 PF09073.8 T033518_1 - 0.53 9.4 25.1 0.83 8.8 25.1 1.2 1 0 0 1 1 1 0 BUD22 Pox_Ag35 PF03286.12 T033518_1 - 1 9.0 20.9 2.5 7.7 20.9 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Vfa1 PF08432.8 T033518_1 - 1.3 9.2 14.5 2.6 8.2 14.5 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC27 PF09507.8 T033518_1 - 1.4 8.1 17.2 2.6 7.2 17.2 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RNA_pol_3_Rpc31 PF11705.6 T033518_1 - 1.5 8.9 33.7 2.5 8.1 33.7 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Slu7 PF11708.6 T033518_1 - 1.7 8.2 19.5 2.7 7.6 19.5 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Nop14 PF04147.10 T033518_1 - 1.7 6.6 28.0 2.4 6.2 28.0 1.1 1 0 0 1 1 1 0 Nop14-like family DUF1168 PF06658.10 T033518_1 - 2.3 7.9 22.1 4.8 6.9 22.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DUF2457 PF10446.7 T033518_1 - 3.4 6.6 42.1 4.9 6.1 42.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF1510 PF07423.9 T033518_1 - 4.1 6.7 25.0 7.4 5.8 25.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4820 PF16091.3 T033518_1 - 4.2 6.5 12.6 6.4 5.9 12.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) NARP1 PF12569.6 T033518_1 - 7.1 5.3 17.1 10 4.8 17.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Mucin PF01456.15 T033518_2 - 0.54 10.1 18.7 0.91 9.4 18.7 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2052 PF09747.7 T033518_2 - 0.66 10.0 10.4 1 9.3 10.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) YL1 PF05764.11 T033518_2 - 1.1 9.3 21.4 1.7 8.6 21.4 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DUF3439 PF11921.6 T033518_2 - 1.1 9.1 12.7 2 8.2 12.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Rtf2 PF04641.10 T033518_2 - 2.8 7.1 19.4 4.6 6.4 19.4 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger PcfK PF14058.4 T033518_2 - 3.5 7.8 15.3 6.8 6.8 15.3 1.3 1 0 0 1 1 1 0 PcfK-like protein CPSF100_C PF13299.4 T033518_2 - 3.6 7.6 11.8 5.8 6.9 11.8 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1168 PF06658.10 T033518_2 - 5.4 6.7 29.6 11 5.7 29.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Ferlin_C PF16165.3 T033518_2 - 6.3 6.6 14.0 11 5.8 14.0 1.3 1 0 0 1 1 1 0 Ferlin C-terminus SR-25 PF10500.7 T033518_2 - 6.4 6.2 25.1 11 5.4 25.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1725 PF08333.9 T033518_3 - 0.0056 16.2 0.8 0.013 15.1 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Anoctamin PF04547.10 T317619_3 - 0.12 11.0 3.8 0.28 9.8 2.8 1.9 2 0 0 2 2 2 0 Calcium-activated chloride channel DUF4834 PF16118.3 T317619_3 - 1 10.2 0.0 1 10.2 0.0 4.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4834) DUF1028 PF06267.10 T258958_2 - 4.4 6.9 6.6 9.7 5.8 6.6 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF1028) Gly-zipper_YMGG PF13441.4 T173640_2 - 0.066 12.8 1.5 0.14 11.8 1.5 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper Transposase_22 PF02994.12 T205078_2 - 6.7e-73 245.5 4.4 1e-72 244.9 4.4 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T205078_2 - 8.4e-08 32.0 0.9 1.5e-07 31.2 0.9 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T205078_2 - 0.012 15.8 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T205078_3 - 1e-47 162.6 19.0 2.8e-47 161.2 19.0 1.5 1 1 0 1 1 1 1 L1 transposable element Syntaxin-6_N PF09177.9 T205078_3 - 0.00092 19.6 7.6 0.0023 18.3 7.6 1.6 1 0 0 1 1 1 1 Syntaxin 6, N-terminal EzrA PF06160.10 T205078_3 - 0.0053 14.9 9.7 0.021 12.9 9.5 1.7 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA Seryl_tRNA_N PF02403.20 T205078_3 - 0.011 15.9 5.3 0.023 14.8 5.3 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain PspA_IM30 PF04012.10 T205078_3 - 0.029 13.8 4.9 0.046 13.1 4.9 1.2 1 0 0 1 1 1 0 PspA/IM30 family Tup_N PF08581.8 T205078_3 - 0.032 14.4 0.7 0.032 14.4 0.7 2.5 2 0 0 2 2 2 0 Tup N-terminal Nup54 PF13874.4 T205078_3 - 0.27 11.2 8.7 0.5 10.3 8.7 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 HSBP1 PF06825.10 T205078_3 - 0.31 10.9 6.1 0.64 9.9 0.6 2.4 1 1 1 2 2 2 0 Heat shock factor binding protein 1 DUF342 PF03961.11 T205078_3 - 1.8 6.9 5.6 2.7 6.3 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) XhlA PF10779.7 T205078_3 - 1.9 8.6 12.2 7.1 6.8 1.9 2.6 2 0 0 2 2 2 0 Haemolysin XhlA Prefoldin_2 PF01920.18 T205078_3 - 2.1 8.2 11.6 2.8 7.8 1.0 2.4 2 0 0 2 2 2 0 Prefoldin subunit DUF1664 PF07889.10 T205078_3 - 3.9 7.4 5.6 16 5.4 1.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.7 T205078_3 - 5.3 7.3 8.5 4.6 7.5 0.7 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.10 T205078_3 - 5.9 6.8 13.8 0.15 11.9 6.8 1.9 2 1 0 2 2 1 0 Laminin Domain II DUF1725 PF08333.9 T277131_3 - 0.054 13.1 0.1 0.1 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) TT_ORF2 PF02957.13 T353453_1 - 0.19 12.5 0.1 0.19 12.5 0.1 2.4 2 0 0 2 2 2 0 TT viral ORF2 CD225 PF04505.10 T367903_2 - 1.3e-20 73.1 2.1 1.4e-19 69.9 0.1 2.8 2 0 0 2 2 2 1 Interferon-induced transmembrane protein FXR_C1 PF16096.3 T069822_3 - 0.62 10.2 2.2 1.2 9.2 2.2 1.4 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 Metallothi_Euk2 PF12809.5 T263544_1 - 6.8 6.9 8.5 0.16 12.1 1.6 1.8 2 0 0 2 2 2 0 Eukaryotic metallothionein Yae1_N PF09811.7 T229466_2 - 0.99 9.0 7.0 2.2 7.9 7.0 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal DUF2116 PF09889.7 T291742_3 - 0.0078 16.1 0.2 0.032 14.1 0.2 2.1 1 0 0 1 1 1 1 Uncharacterized protein containing a Zn-ribbon (DUF2116) Gag_p30 PF02093.14 T297822_3 - 0.00034 20.1 0.0 0.00055 19.4 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T297822_3 - 0.0098 15.3 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Colipase-like PF15083.4 T090321_1 - 1e-46 156.8 26.6 1.8e-38 130.4 13.6 3.0 2 1 1 3 3 3 2 Colipase-like Transposase_1 PF01359.16 T261593_3 - 1.9e-23 82.0 1.0 1.7e-12 46.9 0.2 2.6 2 0 0 2 2 2 2 Transposase (partial DDE domain) RNase_H PF00075.22 T250479_1 - 1.1e-15 57.9 0.2 4.1e-15 56.1 0.2 1.8 1 1 0 1 1 1 1 RNase H rve PF00665.24 T250479_1 - 3.7e-06 27.0 0.0 6.9e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve PF00665.24 T250479_2 - 0.0013 18.8 0.0 0.0019 18.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DUF4705 PF15788.3 T324660_1 - 5.9e-10 39.1 107.6 1.4e-05 25.1 1.4 9.4 7 4 3 10 10 10 6 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324660_2 - 1.2e-05 25.3 21.8 4.8e-05 23.4 5.9 11.7 9 4 5 14 14 14 6 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324660_3 - 3.1e-14 52.8 97.6 1.6e-05 24.9 0.8 9.7 6 3 2 8 8 8 5 Domain of unknown function (DUF4705) Wbp11 PF09429.8 T093973_1 - 0.086 13.1 8.7 0.18 12.0 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 CD225 PF04505.10 T367902_2 - 2.6e-20 72.2 0.1 1.2e-19 70.1 0.1 2.2 1 0 0 1 1 1 1 Interferon-induced transmembrane protein RVT_1 PF00078.25 T114404_2 - 3.3e-21 75.7 1.4 3.3e-21 75.7 1.4 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T114404_3 - 6.2e-28 97.6 1.2 9.9e-28 96.9 1.2 1.2 1 0 0 1 1 1 1 L1 transposable element Transposase_1 PF01359.16 T045404_3 - 2.8e-27 94.3 0.1 6.6e-27 93.1 0.1 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) zf-BED PF02892.13 T060453_1 - 7.5e-08 32.2 0.4 0.43 10.5 0.1 4.5 4 0 0 4 4 4 3 BED zinc finger DUF3505 PF12013.6 T060453_1 - 0.049 13.9 0.2 62 4.0 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3505) DUF678 PF05077.10 T060453_1 - 0.12 12.3 1.7 38 4.4 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF678) Spt5_N PF11942.6 T060453_1 - 6.2 7.7 11.4 13 6.7 0.0 3.2 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal SR-25 PF10500.7 T214237_2 - 6.9 6.1 18.6 12 5.3 18.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Transposase_1 PF01359.16 T351118_2 - 0.034 13.9 0.1 0.074 12.8 0.1 1.4 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_1 PF01359.16 T351118_3 - 6.1e-21 73.9 7.5 1.4e-20 72.8 4.6 2.4 2 0 0 2 2 2 1 Transposase (partial DDE domain) DDE_3 PF13358.4 T351118_3 - 0.0027 17.4 0.4 0.0048 16.5 0.4 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BEN PF10523.7 T351118_3 - 0.057 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 BEN domain RCDG1 PF15725.3 T351118_3 - 1.5 9.2 4.1 2.9 8.3 4.1 1.4 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein HERV-K_REC PF15695.3 T355647_1 - 0.0029 17.5 0.4 0.0055 16.6 0.4 1.3 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 GP41 PF00517.15 T355647_2 - 1.2e-16 61.0 4.0 2.1e-16 60.2 4.0 1.3 1 0 0 1 1 1 1 Retroviral envelope protein Gag_p30 PF02093.14 T069164_1 - 9.2e-23 80.7 0.1 1.4e-22 80.2 0.1 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T069164_1 - 3.7e-11 42.8 0.1 6.3e-11 42.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T069164_1 - 1.5e-05 24.7 2.4 1.5e-05 24.7 2.4 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T069164_1 - 0.032 13.8 2.7 0.084 12.5 2.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger rve PF00665.24 T069164_2 - 5.7e-21 74.8 0.0 9.9e-21 74.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T069164_2 - 1.8e-20 73.4 0.0 2.7e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 RNase H TLV_coat PF00429.17 T069164_2 - 5.6e-16 58.2 3.3 1e-15 57.4 3.3 1.4 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RVP PF00077.18 T069164_2 - 0.00085 19.4 0.0 0.0017 18.5 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_3 PF13456.4 T069164_2 - 0.21 11.2 0.0 0.43 10.1 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like TLV_coat PF00429.17 T069164_3 - 9.2e-21 74.0 8.9 7.1e-16 57.9 2.9 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) Gag_MA PF01140.17 T069164_3 - 0.0011 18.5 0.1 0.0025 17.4 0.1 1.5 1 0 0 1 1 1 1 Matrix protein (MA), p15 PLA2_inh PF02988.13 T035080_3 - 0.13 12.8 4.2 0.27 11.8 4.2 1.5 1 0 0 1 1 1 0 Phospholipase A2 inhibitor UPAR_LY6 PF00021.19 T035080_3 - 0.26 11.9 5.1 0.48 11.0 5.1 1.4 1 0 0 1 1 1 0 u-PAR/Ly-6 domain Mit_proteolip PF08039.9 T001139_1 - 0.77 10.0 2.8 1.8 8.8 2.8 1.6 1 0 0 1 1 1 0 Mitochondrial proteolipid Orn_DAP_Arg_deC PF00278.20 T007023_1 - 3.9e-11 42.9 0.0 6.9e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DUF1725 PF08333.9 T007023_1 - 0.13 11.9 0.3 0.26 10.9 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Orn_Arg_deC_N PF02784.14 T007023_2 - 3e-05 23.5 0.0 4.2e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Glucokinase PF02685.14 T108852_2 - 0.061 12.2 0.0 0.089 11.6 0.0 1.1 1 0 0 1 1 1 0 Glucokinase RVT_1 PF00078.25 T315171_2 - 4.2e-28 98.2 0.1 6.9e-28 97.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T228205_2 - 7.7e-08 31.5 0.2 1.3e-07 30.7 0.2 1.3 1 0 0 1 1 1 1 L1 transposable element DUF3439 PF11921.6 T364252_2 - 0.0072 16.2 4.2 0.013 15.3 4.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) DUF2256 PF10013.7 T364252_2 - 0.1 12.6 0.3 0.31 11.1 0.3 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) Transposase_22 PF02994.12 T114444_1 - 1.3e-102 343.2 20.3 2.5e-102 342.3 20.3 1.3 1 0 0 1 1 1 1 L1 transposable element Med2 PF11214.6 T114444_1 - 0.0018 18.3 3.1 0.0038 17.2 2.0 2.1 2 0 0 2 2 2 1 Mediator complex subunit 2 GAS PF13851.4 T114444_1 - 0.0019 17.4 13.0 0.0033 16.7 13.0 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.20 T114444_1 - 0.0049 16.9 8.1 0.01 15.9 8.1 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF4613 PF15390.4 T114444_1 - 0.0051 15.1 1.7 0.0073 14.6 1.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4613) Sec34 PF04136.13 T114444_1 - 0.018 14.8 2.8 0.029 14.1 2.8 1.3 1 0 0 1 1 1 0 Sec34-like family Syntaxin-6_N PF09177.9 T114444_1 - 0.035 14.5 7.3 0.09 13.2 6.8 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF465 PF04325.11 T114444_1 - 0.036 13.9 1.1 0.11 12.4 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF465) Occludin_ELL PF07303.11 T114444_1 - 0.039 14.5 5.1 0.098 13.2 5.1 1.7 1 0 0 1 1 1 0 Occludin homology domain ArAE_2_N PF10337.7 T114444_1 - 0.14 11.0 0.3 0.2 10.5 0.3 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal APG6 PF04111.10 T114444_1 - 0.21 10.8 11.2 0.32 10.2 11.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1664 PF07889.10 T114444_1 - 0.25 11.2 3.3 0.42 10.5 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF342 PF03961.11 T114444_1 - 0.95 7.9 8.2 1.4 7.3 8.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.12 T114444_1 - 1.2 8.7 11.4 2 8.1 11.4 1.2 1 0 0 1 1 1 0 IncA protein JIP_LZII PF16471.3 T114444_1 - 1.8 8.7 11.1 2.6 8.2 3.0 2.8 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II KLRAQ PF10205.7 T114444_1 - 5 7.3 12.5 0.8 9.9 5.9 2.4 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Exo_endo_phos_2 PF14529.4 T114444_2 - 1.7e-09 37.4 1.1 2.7e-09 36.8 1.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T114444_2 - 0.031 14.4 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T114444_3 - 1.1e-29 103.3 0.4 2e-29 102.5 0.4 1.3 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T114444_3 - 0.017 15.2 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Homeobox PF00046.27 T136335_2 - 2.7e-05 23.8 0.0 5.6e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Homeobox domain RBP_receptor PF14752.4 T358357_3 - 1e-39 136.5 1.8 1.4e-39 136.1 1.8 1.1 1 0 0 1 1 1 1 Retinol binding protein receptor Transposase_1 PF01359.16 T346943_1 - 2.7e-08 33.4 3.6 5.9e-08 32.3 3.6 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T346943_2 - 3.7e-14 52.2 0.3 9.7e-14 50.9 0.3 1.8 1 1 0 1 1 1 1 Transposase (partial DDE domain) HTH_5 PF01022.18 T346943_2 - 0.029 14.1 0.0 0.056 13.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.5 T346943_2 - 0.12 12.2 0.0 0.3 10.9 0.0 1.6 2 0 0 2 2 2 0 MarR family RNA_pol_Rpc4 PF05132.12 T266400_1 - 0.00063 20.1 4.5 0.00073 19.9 4.5 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 DDHD PF02862.15 T266400_1 - 0.014 15.4 3.3 0.014 15.4 3.3 1.2 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.14 T266400_1 - 0.43 10.5 4.7 0.43 10.5 4.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3807 PF12720.5 T266400_1 - 1.3 9.2 24.1 1.9 8.7 24.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DAG_kinase_N PF14513.4 T266400_1 - 2.1 8.4 12.7 2.9 7.9 12.7 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus DUF1510 PF07423.9 T266400_1 - 5.4 6.3 20.0 7.2 5.9 20.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Presenilin PF01080.15 T266400_1 - 5.9 5.4 18.1 7.5 5.1 18.1 1.0 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.12 T266400_3 - 0.00022 21.6 2.7 0.00022 21.6 2.7 1.1 1 0 0 1 1 1 1 RNA polymerase III RPC4 DUF913 PF06025.10 T266400_3 - 0.07 11.9 6.6 0.077 11.8 6.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.15 T266400_3 - 0.32 11.0 6.8 0.32 10.9 6.8 1.1 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.10 T266400_3 - 2.7 7.6 28.8 3.1 7.4 28.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1388 PF07142.10 T172377_3 - 1.4 8.8 4.1 89 3.0 0.4 3.4 3 0 0 3 3 3 0 Repeat of unknown function (DUF1388) Myb_DNA-bind_4 PF13837.4 T265110_2 - 1.6e-19 69.9 0.7 3.1e-19 69.0 0.7 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.5 T265110_2 - 8.7e-05 23.1 1.0 0.0002 22.0 1.0 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.4 T265110_2 - 0.017 15.1 1.5 0.047 13.6 1.5 1.7 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain RVP PF00077.18 T275254_3 - 0.00033 20.7 0.0 0.00063 19.8 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Gag_p30 PF02093.14 T275254_3 - 0.016 14.6 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein DUF378 PF04070.10 T379782_2 - 0.99 9.2 26.5 9.3 6.1 0.6 6.8 6 2 1 7 7 7 0 Domain of unknown function (DUF378) LHC PF00556.18 T379782_2 - 1.1 9.3 19.9 26 5.0 0.1 8.7 10 0 0 10 10 10 0 Antenna complex alpha/beta subunit MEF2_binding PF09047.8 T379782_2 - 2.1 8.1 26.1 33 4.3 0.4 7.6 8 0 0 8 8 8 0 MEF2 binding PTPRCAP PF15713.3 T008085_2 - 0.37 10.9 34.7 0.55 10.4 34.7 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.12 T008085_2 - 0.8 7.8 24.7 1 7.4 24.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.10 T008085_2 - 3.3 6.9 35.3 4.7 6.4 35.3 1.1 1 0 0 1 1 1 0 SDA1 DDHD PF02862.15 T008085_3 - 0.0012 18.9 4.2 0.0016 18.5 4.2 1.1 1 0 0 1 1 1 1 DDHD domain RNA_pol_Rpc4 PF05132.12 T008085_3 - 0.084 13.2 16.1 0.13 12.6 16.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 RP-C_C PF11800.6 T008085_3 - 0.21 11.5 7.2 0.29 11.0 7.2 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region NPR3 PF03666.11 T008085_3 - 0.22 10.1 27.1 0.32 9.6 27.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Afi1 PF07792.10 T008085_3 - 0.31 11.4 8.7 0.62 10.4 8.7 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking rve PF00665.24 T023856_1 - 1.8e-14 53.8 0.0 2.8e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain dUTPase PF00692.17 T023856_3 - 4.8e-14 52.0 0.0 7.4e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 dUTPase Epiglycanin_C PF14654.4 T300735_1 - 3.6e-09 36.5 0.7 7.5e-09 35.4 0.7 1.5 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300735_1 - 2.2e-06 27.5 4.4 5.1e-06 26.4 4.4 1.5 1 0 0 1 1 1 1 Mucin-like Mucin-like PF16058.3 T300735_3 - 0.012 15.5 5.1 0.027 14.4 5.1 1.6 1 0 0 1 1 1 0 Mucin-like Herpes_LMP1 PF05297.9 T300735_3 - 6.8 5.7 8.3 10 5.0 8.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF1117 PF06547.10 T227245_3 - 0.0029 18.0 1.6 0.0056 17.1 1.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1117) DUF3915 PF13054.4 T300284_1 - 0.00068 19.5 3.8 0.00094 19.0 3.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 T300284_1 - 0.3 9.2 11.9 0.39 8.8 11.9 1.0 1 0 0 1 1 1 0 Atrophin-1 family PRP38_assoc PF12871.5 T300284_1 - 0.54 10.7 15.6 0.75 10.2 15.6 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term API5 PF05918.9 T300284_2 - 3.9 6.0 12.3 5.1 5.7 12.3 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) FoP_duplication PF13865.4 T300284_2 - 8.7 6.8 14.4 15 6.1 14.4 1.3 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 SPX PF03105.17 T323513_1 - 0.0045 16.8 5.5 0.0047 16.8 5.5 1.2 1 0 0 1 1 1 1 SPX domain FAM76 PF16046.3 T323513_1 - 2.2 7.4 10.3 3.2 6.9 10.3 1.1 1 0 0 1 1 1 0 FAM76 protein DUF4834 PF16118.3 T323513_3 - 0.00062 20.6 7.7 0.0012 19.7 3.8 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4834) DUF1510 PF07423.9 T323513_3 - 0.0027 17.0 0.1 0.073 12.4 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1510) Shisa PF13908.4 T323513_3 - 0.0058 16.8 14.0 0.039 14.1 5.1 2.2 1 1 1 2 2 2 2 Wnt and FGF inhibitory regulator V_ATPase_I PF01496.17 T323513_3 - 0.008 14.0 9.1 0.011 13.5 9.1 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Tmemb_9 PF05434.9 T323513_3 - 0.023 14.4 0.7 0.023 14.4 0.7 2.3 2 0 0 2 2 2 0 TMEM9 Sigma_reg_N PF13800.4 T323513_3 - 0.025 14.7 4.2 0.025 14.7 4.2 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal EphA2_TM PF14575.4 T323513_3 - 0.033 14.8 11.7 4.5 8.0 12.0 3.1 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Peptidase_S49_N PF08496.8 T323513_3 - 0.06 13.3 0.2 0.06 13.3 0.2 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4446 PF14584.4 T323513_3 - 0.96 9.3 3.9 0.59 10.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF2749 PF10907.6 T323513_3 - 9.1 6.4 9.0 8 6.6 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) Plasmodium_HRP PF05403.9 T228151_1 - 0.66 9.6 157.2 2.8 7.6 33.6 4.0 1 1 3 4 4 4 0 Plasmodium histidine-rich protein (HRPII/III) Plasmodium_HRP PF05403.9 T228151_2 - 0.085 12.5 122.9 2.5e+02 1.2 47.2 3.9 1 1 1 2 2 2 0 Plasmodium histidine-rich protein (HRPII/III) Plasmodium_HRP PF05403.9 T228151_3 - 6.7e-06 25.9 156.7 0.14 11.8 46.3 4.0 1 1 3 4 4 4 4 Plasmodium histidine-rich protein (HRPII/III) CCDC24 PF15669.3 T246243_2 - 3 7.6 5.5 6.3 6.5 5.5 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family RVT_1 PF00078.25 T189405_1 - 0.00057 19.3 0.0 0.00082 18.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T189405_2 - 1e-05 25.5 0.0 1.8e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T189405_3 - 3e-05 24.1 0.0 4.9e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T037596_1 - 8.1e-53 179.0 4.5 5.9e-44 150.0 1.7 2.2 2 0 0 2 2 2 2 Gag P30 core shell protein RVP PF00077.18 T037596_2 - 3.1e-13 49.7 0.0 5.6e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.4 T037596_2 - 0.0061 17.1 0.0 0.011 16.3 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.4 T037596_2 - 0.0065 16.9 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Gag_p30 PF02093.14 T037596_3 - 2.5e-25 89.1 0.4 3.7e-25 88.6 0.4 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T037596_3 - 1.2e-08 34.6 0.0 1.8e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T310079_2 - 2.3e-05 24.1 2.6 6.2e-05 22.8 2.6 1.8 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.18 T310079_2 - 0.0012 18.9 0.0 0.0023 18.0 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_5 PF14787.4 T310079_2 - 0.86 9.2 3.9 2.3 7.9 3.9 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger DUF1725 PF08333.9 T310079_3 - 0.011 15.2 0.2 0.028 14.0 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) zf-BED PF02892.13 T060456_2 - 2.1e-07 30.8 0.5 0.52 10.3 0.1 4.3 4 0 0 4 4 4 3 BED zinc finger DUF3505 PF12013.6 T060456_2 - 0.1 12.9 0.2 76 3.7 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3505) DUF678 PF05077.10 T060456_2 - 0.33 11.0 2.1 46 4.1 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF678) Metallothi_Euk2 PF12809.5 T263541_3 - 0.069 13.3 1.6 0.22 11.7 1.6 1.8 1 0 0 1 1 1 0 Eukaryotic metallothionein FlaC_arch PF05377.9 T330816_1 - 5.2e-05 23.4 44.0 0.39 11.0 1.0 8.3 2 2 5 7 7 7 6 Flagella accessory protein C (FlaC) HrpB7 PF09486.8 T330816_1 - 5.9e-05 23.4 20.1 1 9.6 0.2 5.4 2 2 3 5 5 5 4 Bacterial type III secretion protein (HrpB7) ERM PF00769.17 T330816_1 - 0.002 17.9 47.0 0.0036 17.0 12.0 3.5 2 1 2 4 4 4 3 Ezrin/radixin/moesin family Reo_sigmaC PF04582.10 T330816_1 - 0.0021 17.4 0.0 1.9 7.6 0.0 2.3 2 0 0 2 2 2 2 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.7 T330816_1 - 0.069 13.0 38.4 1.1 9.2 3.9 4.4 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BLOC1_2 PF10046.7 T330816_1 - 0.33 11.1 4.8 4.1 7.7 0.4 3.5 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.10 T330816_1 - 0.79 9.6 23.6 1.9 8.4 4.8 4.7 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) Toxin_18 PF08087.9 T099558_3 - 0.47 10.4 5.8 3.9 7.4 2.1 3.5 2 0 0 2 2 2 0 Conotoxin O-superfamily EF-hand_7 PF13499.4 T156314_3 - 6.1e-14 52.1 0.0 1.1e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 T156314_3 - 4.1e-11 41.5 0.1 8.1e-05 21.8 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 T156314_3 - 2.2e-07 30.4 0.1 6.9e-06 25.6 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.4 T156314_3 - 6.3e-07 28.5 0.1 0.025 14.0 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T156314_3 - 7.3e-07 28.5 0.0 0.0011 18.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain SERTA PF06031.11 T105649_2 - 1.5e-12 46.8 2.8 3.5e-12 45.6 2.8 1.7 1 0 0 1 1 1 1 SERTA motif UPF0730 PF15827.3 T105649_2 - 9e-12 44.9 3.0 2.2e-11 43.7 3.0 1.7 1 0 0 1 1 1 1 UPF0730 unknown protein family Methyltransf_6 PF03737.13 T374593_2 - 0.11 12.5 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Demethylmenaquinone methyltransferase rve PF00665.24 T374593_3 - 4.5e-14 52.5 0.0 7.3e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T374593_3 - 1.6e-07 30.9 0.0 2.6e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.8 T374593_3 - 1e-06 28.8 0.2 3e-06 27.3 0.2 1.9 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RNase_H PF00075.22 T374593_3 - 7.1e-05 22.9 0.0 0.00013 22.1 0.0 1.3 1 0 0 1 1 1 1 RNase H Metallothi_Euk2 PF12809.5 T263546_3 - 7.7 6.7 8.5 0.19 11.9 1.6 1.9 2 0 0 2 2 2 0 Eukaryotic metallothionein RVP PF00077.18 T126058_1 - 1.9e-23 82.5 0.1 3.5e-23 81.7 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_5 PF14787.4 T126058_1 - 7.8e-17 60.6 4.5 1.8e-16 59.4 4.5 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger HERV-K_REC PF15695.3 T126058_1 - 4.9e-06 26.4 1.5 8.5e-06 25.6 1.5 1.3 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 RVT_1 PF00078.25 T126058_1 - 1.7e-05 24.4 0.0 2.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) dUTPase PF00692.17 T126058_1 - 0.015 14.8 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 dUTPase gag-asp_proteas PF13975.4 T126058_1 - 0.02 15.3 0.0 0.035 14.5 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.4 T126058_1 - 0.11 13.0 0.0 0.2 12.2 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease IN_DBD_C PF00552.19 T126058_3 - 8.1e-07 28.1 0.6 1.4e-06 27.3 0.6 1.4 1 0 0 1 1 1 1 Integrase DNA binding domain Trypsin PF00089.24 T338759_1 - 1.3e-08 34.8 0.0 2.3e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 T338759_1 - 0.0066 16.7 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Paired_CXXCH_1 PF09699.8 T078885_2 - 0.058 13.0 0.1 0.14 11.7 0.1 1.7 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) DUF4551 PF15087.4 T021193_2 - 3.7 6.1 8.1 4.7 5.8 8.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) IQ PF00612.25 T272749_1 - 0.0042 16.6 0.1 0.0042 16.6 0.1 2.9 3 0 0 3 3 3 1 IQ calmodulin-binding motif Transposase_1 PF01359.16 T206689_2 - 1.9e-16 59.5 1.3 8.9e-16 57.4 1.3 2.1 1 1 0 1 1 1 1 Transposase (partial DDE domain) KRAB PF01352.25 T325140_3 - 7e-11 41.5 0.9 2.1e-10 39.9 1.4 1.5 2 0 0 2 2 2 1 KRAB box Sec8_exocyst PF04048.12 T111717_1 - 0.12 12.1 1.6 0.19 11.5 1.6 1.1 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Transposase_22 PF02994.12 T111717_2 - 0.0013 17.5 3.8 0.0015 17.3 2.2 1.7 2 0 0 2 2 2 1 L1 transposable element Pentapeptide_2 PF01469.16 T051540_1 - 0.0051 16.5 6.3 0.51 10.1 1.1 2.4 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Coilin_N PF15862.3 T143264_3 - 5.5 6.7 9.4 2.2 8.0 0.0 3.1 3 0 0 3 3 3 0 Coilin N-terminus DZR PF12773.5 T315381_1 - 0.017 15.0 2.3 0.07 13.0 2.3 2.1 1 0 0 1 1 1 0 Double zinc ribbon IN_DBD_C PF00552.19 T265516_1 - 2.4e-06 26.6 0.6 5.4e-06 25.5 0.6 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain rve PF00665.24 T265516_1 - 0.0048 17.0 0.0 0.0098 16.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T265516_2 - 6.7e-16 58.7 0.0 1e-15 58.1 0.0 1.2 1 0 0 1 1 1 1 RNase H RVT_thumb PF06817.12 T265516_2 - 8.9e-16 57.2 0.2 2.1e-15 56.0 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain Integrase_Zn PF02022.17 T265516_2 - 3.5e-15 55.5 1.3 3.5e-15 55.5 1.3 2.0 2 0 0 2 2 2 1 Integrase Zinc binding domain Gag_p10 PF02337.15 T265516_2 - 6.3e-08 32.2 0.0 1.4e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral GAG p10 protein rve PF00665.24 T265516_2 - 0.0011 19.0 0.1 0.0026 17.8 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain Yae1_N PF09811.7 T229467_3 - 1 9.0 7.0 2.2 7.9 7.0 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Orn_Arg_deC_N PF02784.14 T007022_2 - 2.7e-12 46.6 0.0 3.7e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 T007022_3 - 3.6e-11 43.0 0.0 6e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Peptidase_S49_N PF08496.8 T188423_1 - 6 6.8 5.6 11 6.0 5.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal GAIN PF16489.3 T229061_1 - 1.5e-28 99.6 0.0 2.4e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Yae1_N PF09811.7 T111375_1 - 0.0085 15.7 11.4 0.016 14.7 11.4 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Yae1_N PF09811.7 T111375_2 - 0.0033 17.0 9.2 0.0057 16.2 9.2 1.4 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Yae1_N PF09811.7 T111375_3 - 0.02 14.5 11.7 0.037 13.6 11.7 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal DUF1028 PF06267.10 T259005_3 - 5.1 6.7 6.6 11 5.6 6.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF1028) PHO4 PF01384.18 T187956_1 - 0.3 10.0 5.1 0.35 9.7 5.1 1.1 1 0 0 1 1 1 0 Phosphate transporter family G3P_acyltransf PF02660.13 T187956_1 - 5.6 6.9 17.7 8.2 6.3 17.7 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase SlyX PF04102.10 T288551_1 - 0.06 13.8 20.7 0.2 12.2 1.9 3.5 2 1 1 3 3 3 0 SlyX PspA_IM30 PF04012.10 T288551_1 - 1.2 8.6 25.7 0.037 13.5 1.3 3.1 2 1 0 3 3 3 0 PspA/IM30 family HrpB7 PF09486.8 T288551_1 - 4 7.7 9.4 6.5 7.0 0.3 3.1 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) CC PF04942.12 T383191_1 - 0.09 12.9 1.9 37 4.5 0.1 4.3 4 0 0 4 4 4 0 CC domain Transposase_22 PF02994.12 T264229_2 - 2.4e-145 483.9 19.9 3.8e-145 483.2 19.9 1.3 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T264229_2 - 4e-08 33.4 0.0 9.2e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Seryl_tRNA_N PF02403.20 T264229_2 - 7.8e-05 22.7 6.0 0.00016 21.7 6.0 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.9 T264229_2 - 0.0039 17.3 11.2 0.014 15.5 11.2 1.8 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) Syntaxin-6_N PF09177.9 T264229_2 - 0.0093 16.4 6.4 0.022 15.2 6.4 1.6 1 0 0 1 1 1 1 Syntaxin 6, N-terminal Exo_endo_phos_2 PF14529.4 T264229_2 - 0.022 14.5 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase GCN5L1 PF06320.11 T264229_2 - 0.031 14.3 3.4 0.025 14.6 1.3 1.9 1 1 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) TBPIP PF07106.11 T264229_2 - 0.04 13.6 9.9 0.1 12.2 9.9 1.7 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) IncA PF04156.12 T264229_2 - 0.2 11.3 10.3 0.36 10.5 10.3 1.3 1 0 0 1 1 1 0 IncA protein APG6 PF04111.10 T264229_2 - 0.3 10.3 11.2 0.54 9.5 11.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Spectrin PF00435.19 T264229_2 - 0.41 11.0 7.1 1 9.8 7.1 1.7 1 0 0 1 1 1 0 Spectrin repeat KLRAQ PF10205.7 T264229_2 - 0.44 10.7 9.0 2.2 8.4 9.0 2.3 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein DUF2203 PF09969.7 T264229_2 - 0.95 10.1 5.8 0.78 10.3 1.4 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF16 PF01519.14 T264229_2 - 2.9 8.3 7.4 40 4.6 7.4 2.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 Jnk-SapK_ap_N PF09744.7 T264229_2 - 10 6.2 14.4 19 5.3 14.4 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 zf-H2C2_2 PF13465.4 T179989_1 - 7.3e-83 269.5 113.6 9.4e-09 35.2 1.8 18.6 18 1 0 18 18 18 15 Zinc-finger double domain zf-C2H2 PF00096.24 T179989_1 - 3.6e-64 209.7 130.6 6.8e-06 26.1 3.6 16.8 16 0 0 16 16 16 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T179989_1 - 6.5e-29 98.0 134.5 0.0073 16.9 2.0 16.8 17 0 0 17 17 17 14 C2H2-type zinc finger KRAB PF01352.25 T179989_1 - 6.1e-25 86.5 0.7 1.5e-24 85.3 0.7 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 T179989_1 - 6.5e-08 32.2 100.5 0.14 12.0 0.5 15.7 15 1 0 15 15 15 11 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 T179989_1 - 2.6e-06 28.0 63.2 0.17 12.5 1.2 7.6 3 1 4 7 7 7 6 zinc-ribbon family Zn-ribbon_8 PF09723.8 T179989_1 - 5.6e-06 26.2 74.2 0.061 13.3 2.6 9.9 4 3 7 11 11 11 7 Zinc ribbon domain C1_4 PF07975.10 T179989_1 - 0.013 15.6 71.8 0.14 12.3 4.1 10.6 3 1 9 12 12 12 0 TFIIH C1-like domain RVT_1 PF00078.25 T291136_3 - 1.6e-45 155.2 2.5 2.4e-45 154.6 2.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSBP1 PF06825.10 T291136_3 - 0.0029 17.4 1.0 0.0029 17.4 1.0 2.0 2 0 0 2 2 2 1 Heat shock factor binding protein 1 DUF1725 PF08333.9 T215544_1 - 6.7e-07 28.7 0.9 1.6e-06 27.5 0.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) IncA PF04156.12 T215544_2 - 2.9 7.5 8.7 6.1 6.5 8.7 1.5 1 0 0 1 1 1 0 IncA protein Transposase_22 PF02994.12 T215544_3 - 2.7e-117 391.6 11.5 4.8e-117 390.8 11.5 1.4 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T215544_3 - 3.7e-42 144.2 1.2 6.5e-42 143.4 1.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T215544_3 - 0.00042 20.4 0.1 0.0019 18.3 0.0 2.0 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family AIG1 PF04548.14 T269168_1 - 4.9e-23 81.4 0.0 7.2e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.21 T269168_1 - 0.0071 16.3 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Presenilin PF01080.15 T097221_2 - 0.0012 17.6 15.6 0.002 16.8 15.6 1.3 1 0 0 1 1 1 1 Presenilin Nop53 PF07767.9 T097221_3 - 1.4 8.1 56.5 2.2 7.5 56.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Presenilin PF01080.15 T097221_3 - 8.3 4.9 25.1 13 4.3 25.1 1.2 1 0 0 1 1 1 0 Presenilin SPAN-X PF07458.10 T380974_3 - 0.00021 21.5 6.6 0.00062 20.0 6.1 2.0 1 1 1 2 2 2 1 Sperm protein associated with nucleus, mapped to X chromosome RS4NT PF08071.10 T194250_1 - 0.09 12.8 19.6 41 4.3 0.1 7.6 8 0 0 8 8 8 0 RS4NT (NUC023) domain Toxin_18 PF08087.9 T020150_3 - 0.13 12.2 4.4 1.1 9.1 0.1 2.8 2 0 0 2 2 2 0 Conotoxin O-superfamily YjbT PF17089.3 T035722_1 - 0.014 15.3 3.2 1.7 8.6 0.1 3.4 3 0 0 3 3 3 0 Uncharacterised protein family Ada_Zn_binding PF02805.14 T035722_3 - 0.00035 20.4 3.9 16 5.5 0.1 4.8 2 1 3 5 5 5 4 Metal binding domain of Ada Transposase_22 PF02994.12 T171224_3 - 1.2e-116 389.4 16.5 1.8e-116 388.9 16.5 1.1 1 0 0 1 1 1 1 L1 transposable element ATG16 PF08614.9 T171224_3 - 0.74 9.8 5.1 1.3 9.0 5.1 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Syntaxin-6_N PF09177.9 T171224_3 - 3 8.3 4.7 7.7 7.0 4.7 1.7 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Colipase-like PF15083.4 T090332_1 - 2.2e-46 155.8 26.0 4.2e-38 129.2 13.7 2.6 1 1 1 2 2 2 2 Colipase-like Ribosomal_L31 PF01197.16 T062565_2 - 5 7.3 14.6 4 7.6 0.8 3.9 4 0 0 4 4 4 0 Ribosomal protein L31 Ribosomal_L31 PF01197.16 T062565_3 - 2.1 8.5 16.6 2.8 8.1 1.5 3.6 3 0 0 3 3 3 0 Ribosomal protein L31 TLV_coat PF00429.17 T062242_2 - 0.00063 18.4 1.9 0.00063 18.4 1.9 2.0 2 0 0 2 2 2 1 ENV polyprotein (coat polyprotein) Methyltransf_6 PF03737.13 T062242_2 - 0.14 12.2 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Demethylmenaquinone methyltransferase zf-H2C2 PF09337.8 T062242_3 - 3.3e-06 27.1 0.2 6.3e-06 26.2 0.2 1.5 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Transposase_22 PF02994.12 T171283_2 - 1.8e-116 388.9 16.5 2.6e-116 388.4 16.5 1.1 1 0 0 1 1 1 1 L1 transposable element ATG16 PF08614.9 T171283_2 - 1.1 9.3 5.1 1.8 8.5 5.1 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Transposase_22 PF02994.12 T160440_2 - 4.9e-42 144.0 28.5 4.1e-36 124.5 10.9 3.1 3 0 0 3 3 3 3 L1 transposable element Transposase_22 PF02994.12 T160440_3 - 3.6e-19 68.7 0.2 5.8e-19 68.0 0.2 1.3 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T160440_3 - 6.5e-12 45.3 0.9 2.1e-07 30.6 0.5 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) ADAM_CR PF08516.10 T106652_2 - 1.8e-21 76.6 2.8 1.8e-21 76.6 2.8 3.6 3 2 1 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.21 T106652_2 - 2.3e-16 60.2 26.2 2.3e-16 60.2 26.2 3.2 3 0 0 3 3 3 1 Disintegrin Pep_M12B_propep PF01562.17 T106652_3 - 1.7e-16 60.6 0.0 3.8e-16 59.5 0.0 1.5 2 0 0 2 2 2 1 Reprolysin family propeptide Reprolysin PF01421.17 T106652_3 - 4.3e-15 56.0 0.5 6.8e-15 55.4 0.5 1.2 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 T106652_3 - 0.0053 16.8 0.8 0.0089 16.1 0.8 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T106652_3 - 0.0058 17.0 0.2 0.0099 16.3 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T106652_3 - 0.13 11.8 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like RVT_1 PF00078.25 T268138_1 - 1.5e-22 80.1 0.0 2.1e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T268138_1 - 9.4e-11 42.0 0.0 1.8e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 RNase H rve PF00665.24 T268138_3 - 2.7e-08 33.9 0.0 6.1e-08 32.7 0.0 1.6 1 1 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T268138_3 - 3.5e-07 30.2 0.2 8.4e-07 29.0 0.2 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger DUF3809 PF12723.5 T182998_1 - 1.9e-06 28.1 0.2 1.1e+02 3.0 0.0 7.6 3 3 1 9 9 9 0 Protein of unknown function (DUF3809) MurB_C PF02873.14 T182998_1 - 0.0014 18.6 0.3 55 3.8 0.0 5.5 2 1 3 5 5 5 1 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain MurB_C PF02873.14 T182998_2 - 3.4e-05 23.8 1.4 8.2 6.5 0.0 6.4 4 3 1 5 5 5 2 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain DUF3809 PF12723.5 T182998_2 - 8.4e-05 22.7 0.2 1.3e+02 2.7 0.0 6.5 2 1 3 8 8 8 0 Protein of unknown function (DUF3809) DUF3809 PF12723.5 T182998_3 - 0.00048 20.3 0.3 1.5e+02 2.5 0.0 6.6 7 1 0 8 8 8 0 Protein of unknown function (DUF3809) MurB_C PF02873.14 T182998_3 - 0.046 13.7 0.3 1.8e+02 2.2 0.0 5.3 3 2 1 5 5 5 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain GP41 PF00517.15 T256298_1 - 1.9e-21 76.7 6.7 3.3e-21 75.9 6.7 1.3 1 0 0 1 1 1 1 Retroviral envelope protein rve PF00665.24 T256298_1 - 1e-05 25.6 0.0 1.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_Zn PF02022.17 T256298_1 - 1.6e-05 24.6 0.4 4.3e-05 23.2 0.4 1.8 1 0 0 1 1 1 1 Integrase Zinc binding domain RNase_H PF00075.22 T256298_1 - 0.086 12.9 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 RNase H Transposase_22 PF02994.12 T189457_2 - 1.8e-86 290.1 4.1 1.8e-86 290.1 4.1 2.0 2 0 0 2 2 2 1 L1 transposable element Exo_endo_phos PF03372.21 T189457_2 - 8e-07 29.2 0.0 2.2e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T189457_2 - 2.2e-05 24.1 1.8 6.4e-05 22.7 1.8 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.25 T189457_3 - 1e-19 70.8 0.0 2.1e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T291137_1 - 1.6e-45 155.2 2.5 2.4e-45 154.6 2.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSBP1 PF06825.10 T291137_1 - 0.0029 17.4 1.0 0.0029 17.4 1.0 2.0 2 0 0 2 2 2 1 Heat shock factor binding protein 1 Transposase_1 PF01359.16 T346922_1 - 5.1e-14 51.8 0.1 1.3e-13 50.5 0.1 1.7 1 0 0 1 1 1 1 Transposase (partial DDE domain) HTH_5 PF01022.18 T346922_1 - 0.03 14.1 0.0 0.08 12.7 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.5 T346922_1 - 0.17 11.7 0.0 0.43 10.4 0.0 1.6 1 0 0 1 1 1 0 MarR family Transposase_1 PF01359.16 T346922_3 - 4.2e-08 32.8 3.6 8.5e-08 31.8 3.6 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) RVT_1 PF00078.25 T089818_2 - 1.9e-43 148.5 0.2 2.7e-43 147.9 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.4 T089818_3 - 0.022 14.2 0.1 0.035 13.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) MIP-T3 PF10243.7 T223839_1 - 0.14 10.7 44.6 0.2 10.2 44.6 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Presenilin PF01080.15 T223839_1 - 0.84 8.2 16.4 1.2 7.6 16.4 1.1 1 0 0 1 1 1 0 Presenilin Yae1_N PF09811.7 T223839_1 - 2.8 7.6 16.7 0.57 9.8 4.4 2.4 2 0 0 2 2 2 0 Essential protein Yae1, N terminal MIP-T3 PF10243.7 T223839_2 - 0.0014 17.3 43.2 0.002 16.8 43.2 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Mtc1 PF10310.7 T223839_2 - 0.023 13.5 23.0 0.031 13.1 23.0 1.1 1 0 0 1 1 1 0 Maintenance of telomere capping protein 1 DUF1510 PF07423.9 T223839_2 - 1.1 8.6 27.6 1.6 8.0 27.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SAPS PF04499.13 T223839_2 - 1.5 7.4 6.0 2 6.9 6.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Yae1_N PF09811.7 T223839_2 - 4.7 6.9 16.5 2.9 7.5 2.1 2.3 2 0 0 2 2 2 0 Essential protein Yae1, N terminal MIP-T3 PF10243.7 T223839_3 - 0.24 10.0 42.1 0.33 9.5 42.1 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Presenilin PF01080.15 T223839_3 - 3.1 6.3 17.3 4.3 5.8 17.3 1.1 1 0 0 1 1 1 0 Presenilin Yae1_N PF09811.7 T223839_3 - 4.9 6.8 16.3 0.33 10.6 4.3 2.3 2 0 0 2 2 2 0 Essential protein Yae1, N terminal AAA_11 PF13086.4 T223839_3 - 6.1 6.4 14.2 8.9 5.8 14.2 1.1 1 0 0 1 1 1 0 AAA domain GFO_IDH_MocA_C PF02894.15 T001703_2 - 0.068 13.1 0.0 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain DUF4705 PF15788.3 T324658_1 - 2.3e-16 59.6 36.4 1.5e-14 53.8 9.4 21.5 16 4 5 21 21 21 6 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324658_2 - 1.4e-23 82.7 53.6 4.6e-18 65.0 10.4 20.8 15 8 7 22 22 22 10 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324658_3 - 2.3e-16 59.6 173.8 1.8e-09 37.5 1.6 19.7 12 7 2 14 14 14 8 Domain of unknown function (DUF4705) Pentapeptide_4 PF13599.4 T264513_1 - 0.00072 19.5 1.4 32 4.6 0.1 5.9 6 1 0 6 6 6 2 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T264513_2 - 1.4e-09 37.8 1.4 1.7 8.7 0.0 6.3 3 2 3 7 7 7 6 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T264513_3 - 6.1e-06 26.1 0.1 28 4.8 0.0 5.7 4 2 0 5 5 5 4 Pentapeptide repeats (9 copies) EloA-BP1 PF15870.3 T356797_1 - 4.2e-10 40.1 0.1 6.7e-10 39.4 0.1 1.2 1 0 0 1 1 1 1 ElonginA binding-protein 1 PT PF04886.10 T243226_2 - 0.0011 18.3 9.2 0.0019 17.5 5.7 2.9 3 0 0 3 3 3 1 PT repeat PT PF04886.10 T243226_3 - 3.4e-06 26.4 6.0 0.00021 20.6 0.4 2.9 3 0 0 3 3 3 2 PT repeat Fumarate_red_C PF02300.15 T351451_1 - 0.08 12.9 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Fumarate reductase subunit C NPR3 PF03666.11 T351451_1 - 0.13 10.9 15.6 0.16 10.6 15.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1510 PF07423.9 T351451_1 - 0.22 10.8 18.1 0.32 10.3 18.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF913 PF06025.10 T351451_1 - 1.1 8.0 5.2 1.4 7.7 5.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NARP1 PF12569.6 T351451_1 - 1.6 7.4 26.6 2.2 7.0 26.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SpoIIP PF07454.9 T351451_1 - 4.1 6.6 14.7 5.7 6.2 14.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.15 T351451_1 - 6.7 5.2 14.6 9 4.8 14.6 1.1 1 0 0 1 1 1 0 Presenilin AAA_11 PF13086.4 T351451_2 - 0.0057 16.3 5.8 0.0078 15.8 5.8 1.2 1 0 0 1 1 1 1 AAA domain DDHD PF02862.15 T351451_2 - 0.1 12.6 3.5 0.13 12.3 3.5 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.15 T351451_2 - 0.17 10.5 12.1 0.25 9.9 12.1 1.2 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.8 T351451_2 - 0.39 10.9 21.2 0.58 10.3 21.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF913 PF06025.10 T351451_2 - 1.2 7.9 4.0 1.6 7.5 4.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.20 T351451_2 - 4.8 6.2 7.9 6.9 5.7 7.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1510 PF07423.9 T351451_2 - 10 5.4 24.8 14 4.9 24.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF1510 PF07423.9 T351451_3 - 0.013 14.8 11.6 0.018 14.4 11.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DDHD PF02862.15 T351451_3 - 0.37 10.8 5.3 0.48 10.4 5.3 1.1 1 0 0 1 1 1 0 DDHD domain DUF2201_N PF13203.4 T351451_3 - 3.3 7.1 9.2 4.1 6.8 9.2 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain Afi1 PF07792.10 T351451_3 - 4.9 7.5 13.3 9.7 6.5 13.3 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.15 T351451_3 - 6.5 5.2 18.0 9.4 4.7 18.0 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.20 T351451_3 - 9.8 5.2 6.5 14 4.6 6.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Pentapeptide PF00805.20 T138461_1 - 9e-05 21.9 0.8 0.34 10.5 0.1 4.9 5 0 0 5 5 5 1 Pentapeptide repeats (8 copies) Transposase_22 PF02994.12 T346745_2 - 5e-64 216.3 8.9 1.9e-57 194.6 5.4 2.2 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T346745_3 - 3.7e-35 121.3 1.9 6.5e-35 120.5 1.9 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T346745_3 - 4.8e-14 51.9 14.6 2.6e-07 29.7 2.9 2.2 2 0 0 2 2 2 2 L1 transposable element HSBP1 PF06825.10 T346745_3 - 0.025 14.4 0.1 0.058 13.2 0.1 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 RVT_1 PF00078.25 T184583_2 - 9.4e-33 113.5 3.7 1.7e-32 112.6 3.7 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T184583_2 - 2.7e-17 62.6 0.3 4.6e-17 61.8 0.3 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T184583_2 - 0.0026 17.5 0.1 0.0045 16.7 0.1 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RBP_receptor PF14752.4 T358371_1 - 8e-08 31.2 1.7 1.1e-07 30.8 1.7 1.1 1 0 0 1 1 1 1 Retinol binding protein receptor GATase_7 PF13537.4 T222987_1 - 2.9e-16 59.4 0.0 4.4e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.4 T222987_1 - 4.7e-12 46.1 0.0 7e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.6 T222987_1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Aluminium induced protein Gag_p30 PF02093.14 T091446_1 - 1.1e-14 54.4 0.0 1.6e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RNase_H PF00075.22 T091446_2 - 3.1e-12 46.8 0.0 5.4e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 RNase H RVP PF00077.18 T091446_2 - 2.8e-08 33.8 0.0 5.3e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_1 PF00078.25 T091446_2 - 0.011 15.1 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T091446_2 - 0.17 11.2 0.6 0.3 10.4 0.0 1.6 2 0 0 2 2 2 0 Gag P30 core shell protein TLV_coat PF00429.17 T091446_3 - 2.2e-39 135.5 3.4 3.6e-39 134.8 3.4 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) DUF1510 PF07423.9 T091446_3 - 2.5 7.4 14.7 4 6.7 14.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF1510 PF07423.9 T275907_1 - 0.013 14.8 0.0 0.013 14.8 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1510) LRRC37AB_C PF14914.4 T275907_1 - 0.014 15.2 0.2 0.038 13.8 0.2 1.7 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF912 PF06024.10 T275907_1 - 0.055 13.6 0.2 0.055 13.6 0.2 2.6 2 2 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ODV-E18 PF10717.7 T275907_1 - 0.071 12.9 4.9 0.12 12.1 4.9 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 EphA2_TM PF14575.4 T275907_1 - 0.09 13.5 0.2 0.09 13.5 0.2 7.7 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.4 T275907_1 - 0.16 11.8 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF3446 PF11928.6 T275907_1 - 0.26 11.5 7.3 1.1 9.5 7.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) DUF3446 PF11928.6 T275907_2 - 0.03 14.5 11.6 0.077 13.2 11.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) SR-25 PF10500.7 T275907_2 - 1.4 8.4 12.4 2.1 7.8 12.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SelP_N PF04592.12 T275907_2 - 3.1 7.0 17.9 4.9 6.4 17.9 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF912 PF06024.10 T275907_3 - 1.7 8.8 0.0 1.7 8.8 0.0 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Baculo_11_kDa PF06143.9 T257777_1 - 1.3 8.6 4.7 3.8 7.0 4.7 1.8 1 0 0 1 1 1 0 Baculovirus 11 kDa family Peptidase_S49_N PF08496.8 T188441_3 - 5.2 7.0 5.6 9.5 6.2 5.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Peptidase_S49_N PF08496.8 T188425_1 - 5.8 6.9 5.6 11 6.0 5.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MAP1B_neuraxin PF00414.15 T112890_2 - 0.052 13.0 7.2 18 5.0 0.0 4.8 5 0 0 5 5 5 0 Neuraxin and MAP1B repeat Mucin-like PF16058.3 T300737_2 - 0.02 14.8 6.0 0.046 13.7 6.0 1.6 1 0 0 1 1 1 0 Mucin-like Herpes_LMP1 PF05297.9 T300737_2 - 6.1 5.8 8.3 9.3 5.2 8.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Epiglycanin_C PF14654.4 T300737_3 - 3.4e-09 36.5 0.7 6.7e-09 35.6 0.7 1.5 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300737_3 - 2.2e-06 27.5 4.4 4.6e-06 26.5 4.4 1.4 1 0 0 1 1 1 1 Mucin-like COX17 PF05051.11 T316020_3 - 3.4 8.0 5.5 6.4 7.1 3.3 2.7 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) RNase_H PF00075.22 T172324_1 - 2.5e-05 24.4 0.0 4.1e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 RNase H DUF1028 PF06267.10 T258990_3 - 5.2 6.7 6.6 10 5.7 6.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF1028) Nop53 PF07767.9 T097222_1 - 1.7 7.9 56.5 2.5 7.3 56.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Presenilin PF01080.15 T097222_1 - 9.8 4.7 25.1 15 4.0 25.1 1.2 1 0 0 1 1 1 0 Presenilin Presenilin PF01080.15 T097222_3 - 0.0014 17.4 15.5 0.0023 16.6 15.5 1.3 1 0 0 1 1 1 1 Presenilin Transposase_22 PF02994.12 T372538_2 - 5.3e-19 68.2 0.1 7.7e-19 67.6 0.1 1.2 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T372538_3 - 1.6e-70 237.7 24.8 1.5e-69 234.5 24.8 2.0 1 1 0 1 1 1 1 L1 transposable element Syntaxin-6_N PF09177.9 T372538_3 - 0.1 13.0 12.2 0.019 15.4 8.1 1.8 2 0 0 2 2 2 0 Syntaxin 6, N-terminal CorA PF01544.16 T372538_3 - 0.21 10.8 6.3 0.3 10.2 6.3 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF1664 PF07889.10 T372538_3 - 0.35 10.7 2.9 0.66 9.8 2.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ABC_tran_CTD PF16326.3 T372538_3 - 0.81 9.9 8.0 2 8.6 8.0 1.6 1 0 0 1 1 1 0 ABC transporter C-terminal domain Spem1 PF15670.3 T140970_3 - 0.0056 16.1 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 Spermatid maturation protein 1 DUF4575 PF15143.4 T335612_1 - 1.1e-74 248.7 87.5 9.2e-14 51.6 5.5 10.9 6 2 4 10 10 10 10 Domain of unknown function (DUF4575) DUF4575 PF15143.4 T335612_2 - 2.7e-70 234.5 88.8 1.1e-20 74.1 10.3 9.5 6 3 3 9 9 9 9 Domain of unknown function (DUF4575) DUF4575 PF15143.4 T335612_3 - 1e-75 252.1 96.5 8e-17 61.5 10.1 11.3 7 2 4 11 11 11 11 Domain of unknown function (DUF4575) Pentapeptide_4 PF13599.4 T383186_1 - 5.6e-08 32.7 0.3 0.013 15.5 0.0 5.8 6 3 2 8 8 8 5 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T383186_2 - 0.00015 21.7 0.0 5.1 7.2 0.0 5.3 5 2 1 6 6 6 2 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T383186_3 - 0.00039 20.4 0.0 0.014 15.4 0.0 3.5 4 1 0 5 5 5 1 Pentapeptide repeats (9 copies) DUF1664 PF07889.10 T039039_3 - 0.0035 17.2 2.0 0.78 9.6 0.1 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) Laminin_II PF06009.10 T039039_3 - 0.16 11.9 0.0 3.9 7.3 0.0 2.3 1 1 1 2 2 2 0 Laminin Domain II APG6 PF04111.10 T039039_3 - 0.63 9.2 7.9 0.98 8.6 7.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.9 T039039_3 - 1.4 7.6 6.8 1.9 7.2 2.9 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein FliJ PF02050.14 T039039_3 - 2.4 8.2 27.9 4.2 7.5 10.0 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein Retrotrans_gag PF03732.15 T039039_3 - 3.4 7.9 10.5 36 4.6 0.3 3.8 1 1 3 4 4 4 0 Retrotransposon gag protein CENP-F_leu_zip PF10473.7 T039039_3 - 3.7 7.4 7.0 22 5.0 3.7 2.2 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Serine_rich PF08824.8 T039039_3 - 3.8 7.3 18.1 13 5.6 4.9 2.5 1 1 1 2 2 2 0 Serine rich protein interaction domain Snapin_Pallidin PF14712.4 T039039_3 - 7 7.0 18.5 5.1 7.5 4.0 2.4 2 0 0 2 2 2 0 Snapin/Pallidin EzrA PF06160.10 T039039_3 - 8.4 4.3 7.1 12 3.8 7.1 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA rve PF00665.24 T112512_3 - 2.4e-08 34.1 0.0 4.1e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain dUTPase PF00692.17 T112512_3 - 5.5e-08 32.4 0.0 9.3e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 dUTPase DUF3496 PF12001.6 T018765_1 - 2.2e-16 60.1 7.5 4.1e-16 59.2 7.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3496) BAR_3_WASP_bdg PF10456.7 T018765_2 - 0.0001 21.7 0.0 0.00015 21.1 0.0 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein BAR_3_WASP_bdg PF10456.7 T018765_3 - 7.7e-09 35.2 0.3 1.4e-08 34.4 0.3 1.3 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein DUF3496 PF12001.6 T018765_3 - 7.7e-09 35.8 0.0 1.3e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3496) Acetone_carb_G PF08882.9 T035300_2 - 0.18 11.8 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 Acetone carboxylase gamma subunit DUF4705 PF15788.3 T051857_1 - 1.9e-42 143.1 253.2 5.3e-12 45.6 5.6 26.1 16 7 8 24 24 24 19 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T051857_2 - 9.5e-40 134.5 289.6 1.3e-06 28.3 9.1 27.7 10 8 15 27 27 27 18 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T051857_3 - 3.4e-67 222.3 273.7 1.1e-13 51.0 13.7 28.5 13 10 11 24 24 24 21 Domain of unknown function (DUF4705) Gly-zipper_YMGG PF13441.4 T173647_1 - 0.048 13.3 1.5 0.096 12.3 1.5 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper RNase_H PF00075.22 T294831_1 - 5.7e-22 78.3 0.0 9e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 RNase H zf-H2C2 PF09337.8 T294831_1 - 1.3e-07 31.6 0.1 3e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve PF00665.24 T294831_1 - 0.0002 21.4 0.0 0.00037 20.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T294831_2 - 1.1e-19 70.8 0.0 2.6e-19 69.5 0.0 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CD20 PF04103.13 T221539_1 - 0.0057 16.6 5.3 0.0057 16.6 5.3 4.7 3 3 2 5 5 5 1 CD20-like family F-box-like PF12937.5 T035601_1 - 2.4 8.0 6.3 19 5.1 0.1 3.2 3 0 0 3 3 3 0 F-box-like LRRC37 PF15779.3 T148343_1 - 3e-22 78.7 62.5 3e-14 53.1 11.7 6.9 5 2 2 7 7 7 6 Leucine-rich repeat-containing protein 37 family LRRC37 PF15779.3 T148343_2 - 2e-57 191.3 69.4 8.6e-30 102.8 17.4 4.7 1 1 3 4 4 4 4 Leucine-rich repeat-containing protein 37 family DUF1725 PF08333.9 T148343_2 - 0.0008 18.9 1.2 0.0016 17.9 1.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_thumb PF06817.12 T268417_1 - 6.7e-30 102.5 0.1 1.4e-29 101.5 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RNase_H PF00075.22 T268417_1 - 1.5e-11 44.6 0.0 2.9e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 RNase H HERV-K_REC PF15695.3 T268417_1 - 0.0002 21.2 1.0 0.00035 20.4 1.0 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 RVP PF00077.18 T268417_2 - 1.3e-21 76.6 0.1 2.6e-21 75.6 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease dUTPase PF00692.17 T268417_2 - 6.8e-16 58.0 0.0 1.2e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 dUTPase G-patch PF01585.21 T268417_2 - 8.5e-09 35.1 0.4 1.5e-08 34.3 0.4 1.4 1 0 0 1 1 1 1 G-patch domain gag-asp_proteas PF13975.4 T268417_2 - 0.033 14.6 0.0 0.058 13.8 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease rve PF00665.24 T268417_3 - 9.8e-18 64.4 0.0 1.7e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain HERV-K_env_2 PF13804.4 T268417_3 - 1.6e-10 40.9 0.1 2.7e-10 40.1 0.1 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Integrase_Zn PF02022.17 T268417_3 - 4.4e-10 39.2 0.6 1.1e-09 37.9 0.6 1.7 1 0 0 1 1 1 1 Integrase Zinc binding domain IN_DBD_C PF00552.19 T268417_3 - 3.9e-05 22.7 0.5 9.4e-05 21.5 0.5 1.7 1 0 0 1 1 1 1 Integrase DNA binding domain RS4NT PF08071.10 T194253_3 - 0.18 11.8 22.7 48 4.1 0.1 8.5 9 0 0 9 9 9 0 RS4NT (NUC023) domain DUF1943 PF09172.9 T278164_1 - 0.37 9.9 10.2 1.5 7.9 0.3 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1943) DUF1943 PF09172.9 T278164_2 - 0.42 9.7 9.5 1.9 7.6 9.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1943) DUF1943 PF09172.9 T278164_3 - 0.0004 19.6 20.6 0.016 14.3 7.6 3.3 2 1 1 3 3 3 3 Domain of unknown function (DUF1943) MspA PF09203.9 T278164_3 - 0.11 12.2 21.8 2.5 7.8 12.7 3.4 2 1 0 2 2 2 0 MspA Fibrinogen_BP PF08017.9 T222932_1 - 3.3e-19 68.4 18.8 4.1e-09 35.2 0.2 3.1 3 0 0 3 3 3 3 Fibrinogen binding protein DUF3221 PF11518.6 T222932_1 - 0.099 12.9 3.0 16 5.8 0.1 4.9 3 3 2 5 5 5 0 Protein of unknown function (DUF3221) BRCA-2_helical PF09169.8 T222932_1 - 0.1 12.2 15.7 4.3 6.8 0.2 6.3 5 3 4 9 9 9 0 BRCA2, helical DUF3579 PF12112.6 T222932_1 - 0.15 12.5 0.1 21 5.6 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF3579) Fibrinogen_BP PF08017.9 T222932_2 - 5.9e-19 67.6 0.0 1.7e-11 43.1 0.0 3.2 3 1 0 3 3 3 3 Fibrinogen binding protein RVT_1 PF00078.25 T372719_2 - 2.7e-15 56.3 0.0 4.2e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T372719_2 - 0.00016 21.5 7.1 0.00027 20.8 1.5 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T372719_2 - 0.0014 18.2 12.1 0.049 13.2 2.3 2.8 2 0 0 2 2 2 2 GAG-polyprotein viral zinc-finger eIF3g PF12353.6 T372719_2 - 6.1 7.1 6.2 4.4 7.6 1.4 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G CCDC144C PF14915.4 T018826_1 - 6.2e-29 101.0 16.4 6.2e-29 101.0 16.4 1.9 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region BAR_3_WASP_bdg PF10456.7 T018826_1 - 0.00011 21.7 0.0 0.00019 20.8 0.0 1.3 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein CCDC144C PF14915.4 T018826_2 - 2.7e-29 102.1 13.6 2.7e-29 102.1 13.6 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region BAR_3_WASP_bdg PF10456.7 T018826_2 - 1.9e-08 34.0 0.4 1.9e-08 34.0 0.4 1.9 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein Laminin_II PF06009.10 T018826_2 - 1.9 8.3 15.1 0.025 14.5 1.1 2.3 2 0 0 2 2 2 0 Laminin Domain II CCDC144C PF14915.4 T018826_3 - 5.7e-07 28.8 3.0 8.6e-07 28.2 3.0 1.2 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region HERV-K_REC PF15695.3 T354543_1 - 4.6e-41 138.7 5.7 4.6e-41 138.7 5.7 1.7 2 0 0 2 2 2 1 Rec (regulator of expression encoded by corf) of HERV-K-113 IN_DBD_C PF00552.19 T354543_1 - 7.1e-06 25.1 1.1 1.3e-05 24.3 1.1 1.3 1 0 0 1 1 1 1 Integrase DNA binding domain rve PF00665.24 T354543_2 - 2.5e-26 92.1 0.0 4.2e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_Zn PF02022.17 T354543_2 - 6.3e-17 61.1 2.7 1.4e-16 60.0 2.7 1.6 1 0 0 1 1 1 1 Integrase Zinc binding domain RVT_thumb PF06817.12 T354543_3 - 8.3e-29 99.0 0.1 1.8e-28 97.9 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain Gag_p24 PF00607.18 T354543_3 - 2e-25 89.8 0.1 3.2e-25 89.1 0.1 1.3 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) Gag_p10 PF02337.15 T354543_3 - 1.8e-22 78.8 0.2 4.8e-22 77.5 0.2 1.7 1 0 0 1 1 1 1 Retroviral GAG p10 protein RVT_1 PF00078.25 T354543_3 - 1.3e-07 31.3 0.0 2.1e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T354543_3 - 3.2e-07 30.5 0.6 5.4e-07 29.8 0.1 1.7 2 0 0 2 2 2 1 RNase H UPAR_LY6 PF00021.19 T353223_3 - 4.2e-06 27.2 6.1 8.3e-06 26.3 6.1 1.5 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Bactofilin PF04519.11 T235977_2 - 8.7 6.6 12.8 1.5 9.0 3.8 2.4 2 0 0 2 2 2 0 Polymer-forming cytoskeletal Gag_p30 PF02093.14 T089137_1 - 1.6e-14 53.8 0.0 2.3e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein zf-CCHC PF00098.21 T089137_1 - 4.4e-06 26.4 1.0 1.2e-05 25.0 1.0 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.4 T089137_1 - 0.029 13.9 2.7 0.065 12.8 2.7 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.4 T089137_1 - 0.1 12.3 1.1 0.33 10.7 1.1 1.9 1 0 0 1 1 1 0 Zinc knuckle MdoG PF04349.10 T125887_3 - 0.038 12.8 0.4 0.053 12.3 0.4 1.1 1 0 0 1 1 1 0 Periplasmic glucan biosynthesis protein, MdoG Wbp11 PF09429.8 T094002_2 - 0.083 13.2 8.7 0.18 12.1 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 RVT_1 PF00078.25 T056139_1 - 6.4e-07 29.0 0.1 1e-06 28.3 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T056139_2 - 3.2e-73 246.6 11.7 1.6e-71 241.0 11.7 2.4 1 1 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T056139_2 - 4e-09 36.2 0.0 6.5e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Seryl_tRNA_N PF02403.20 T056139_2 - 0.004 17.2 1.5 0.004 17.2 1.5 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain HSBP1 PF06825.10 T056139_2 - 0.008 15.9 4.5 0.027 14.3 0.9 2.6 2 0 0 2 2 2 1 Heat shock factor binding protein 1 NPV_P10 PF05531.10 T056139_2 - 0.1 13.0 0.7 0.27 11.6 0.7 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein COG5 PF10392.7 T056139_2 - 0.31 11.1 2.6 5.1 7.1 0.4 2.4 2 0 0 2 2 2 0 Golgi transport complex subunit 5 RVT_1 PF00078.25 T056139_3 - 5.6e-22 78.2 0.0 1.1e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T056139_3 - 2.6e-06 27.5 0.0 4.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T056139_3 - 0.015 15.0 0.2 0.038 13.7 0.2 1.7 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase rve PF00665.24 T112513_3 - 2.1e-08 34.3 0.0 3.5e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain dUTPase PF00692.17 T112513_3 - 4.6e-08 32.7 0.0 8e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 dUTPase Cornifin PF02389.13 T368565_3 - 6.1e-13 49.0 44.2 1.6e-08 34.7 15.5 4.6 3 1 1 4 4 4 2 Cornifin (SPRR) family Wbp11 PF09429.8 T094036_1 - 0.084 13.1 8.7 0.19 12.0 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 DUF1117 PF06547.10 T227237_1 - 0.0018 18.7 1.6 0.0033 17.8 1.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1117) RNase_H PF00075.22 T200706_1 - 1.3e-13 51.2 0.0 2.1e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 RNase H rve PF00665.24 T200706_3 - 0.036 14.1 0.0 0.066 13.3 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain Transposase_22 PF02994.12 T103725_2 - 2.1e-142 474.2 20.5 2.9e-142 473.7 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103725_2 - 0.03 14.4 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103725_2 - 0.06 13.0 10.5 0.11 12.1 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103725_2 - 0.061 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103725_2 - 0.35 11.3 5.0 0.7 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103725_2 - 0.43 9.8 12.3 0.75 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103725_2 - 1.3 9.1 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103725_2 - 3.1 8.0 7.5 5.3 7.2 6.7 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Transposase_1 PF01359.16 T069602_2 - 3.9e-18 65.0 0.2 3.9e-18 65.0 0.2 2.3 2 0 0 2 2 2 1 Transposase (partial DDE domain) Orn_Arg_deC_N PF02784.14 T007016_2 - 5.4e-12 45.6 0.0 7.6e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 T007016_3 - 7.3e-11 42.0 0.0 1.2e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DMP1 PF07263.9 T229512_1 - 3.1 6.4 10.6 2.6 6.7 9.3 1.4 1 1 0 1 1 1 0 Dentin matrix protein 1 (DMP1) Gemini_C4 PF01492.15 T227642_1 - 0.082 12.7 3.0 1.1 9.1 1.0 2.9 1 1 0 2 2 2 0 Geminivirus C4 protein DUF1725 PF08333.9 T226432_3 - 0.0037 16.7 0.4 0.0068 15.9 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Lamprin PF06403.9 T211123_2 - 0.84 9.5 4.1 0.96 9.3 0.8 2.2 2 0 0 2 2 2 0 Lamprin GP41 PF00517.15 T202685_1 - 3e-10 40.1 0.3 5.5e-10 39.3 0.3 1.4 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_env_2 PF13804.4 T202685_2 - 2.9e-37 127.9 0.2 4.6e-37 127.3 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein NOB1_Zn_bind PF08772.9 T146786_1 - 0.01 15.8 0.1 0.02 14.9 0.1 1.4 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like RVT_1 PF00078.25 T270939_2 - 3.3e-30 105.1 4.2 4.7e-29 101.4 4.2 2.2 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MCD PF05292.9 T270939_2 - 0.026 13.5 0.1 0.046 12.7 0.1 1.3 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase (MCD) RVT_1 PF00078.25 T270939_3 - 0.013 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p24 PF00607.18 T167926_1 - 5.3e-28 98.2 0.0 1.4e-23 83.7 0.0 2.4 2 0 0 2 2 2 2 gag gene protein p24 (core nucleocapsid protein) rve PF00665.24 T167926_1 - 9.9e-22 77.3 0.0 2.7e-21 75.8 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Integrase_Zn PF02022.17 T167926_1 - 3.4e-13 49.2 0.7 9.4e-13 47.7 0.7 1.8 1 0 0 1 1 1 1 Integrase Zinc binding domain RVT_1 PF00078.25 T167926_1 - 1.2e-10 41.2 0.1 7.8e-10 38.5 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) IN_DBD_C PF00552.19 T167926_1 - 6.5e-07 28.4 0.8 1.5e-06 27.3 0.8 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain Gag_p10 PF02337.15 T167926_1 - 1.3e-05 24.8 0.1 3e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 Retroviral GAG p10 protein DDE_Tnp_IS240 PF13610.4 T167926_1 - 0.018 15.1 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 DDE domain RVT_thumb PF06817.12 T167926_2 - 8.9e-17 60.4 0.0 2.2e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVP PF00077.18 T167926_2 - 5e-15 55.5 0.1 1e-14 54.5 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease dUTPase PF00692.17 T167926_2 - 6.5e-14 51.6 0.0 1.1e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 dUTPase RNase_H PF00075.22 T167926_2 - 9.4e-07 29.0 0.0 1.5e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 RNase H IN_DBD_C PF00552.19 T167926_2 - 0.0001 21.4 0.2 0.00022 20.3 0.2 1.5 1 0 0 1 1 1 1 Integrase DNA binding domain Gag_p10 PF02337.15 T167926_2 - 0.0002 21.0 0.0 0.00048 19.8 0.0 1.6 1 0 0 1 1 1 1 Retroviral GAG p10 protein zf-CCHC_5 PF14787.4 T167926_3 - 6.6e-16 57.6 1.3 1.6e-15 56.4 1.3 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger G-patch PF01585.21 T167926_3 - 7.4e-06 25.7 0.4 1.6e-05 24.6 0.4 1.6 1 0 0 1 1 1 1 G-patch domain Gag_p24 PF00607.18 T167926_3 - 0.00083 19.1 0.0 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) HERV-K_REC PF15695.3 T167926_3 - 0.073 13.0 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 Rec (regulator of expression encoded by corf) of HERV-K-113 Transposase_22 PF02994.12 T103701_3 - 2.2e-142 474.1 20.5 3e-142 473.7 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103701_3 - 0.031 14.4 0.0 0.058 13.5 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103701_3 - 0.062 13.0 10.5 0.11 12.1 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103701_3 - 0.063 13.6 2.8 0.11 12.8 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103701_3 - 0.36 11.3 5.0 0.72 10.3 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103701_3 - 0.44 9.7 12.3 0.77 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103701_3 - 1.3 9.1 11.3 0.015 15.3 2.1 2.3 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103701_3 - 3.4 7.8 7.6 5.8 7.1 6.8 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein VCX_VCY PF15231.4 T381763_3 - 4e-05 24.1 0.3 6.2e-05 23.5 0.3 1.1 1 0 0 1 1 1 1 Variable charge X/Y family IQ PF00612.25 T272755_3 - 0.0012 18.3 1.2 0.0054 16.3 0.1 2.5 2 0 0 2 2 2 1 IQ calmodulin-binding motif zf-CCHC PF00098.21 T306121_2 - 0.13 12.2 4.6 1.6 8.8 0.0 3.2 3 0 0 3 3 3 0 Zinc knuckle Gag_p30 PF02093.14 T306121_3 - 1.6e-12 47.3 0.1 2.6e-12 46.6 0.1 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Tektin PF03148.12 T383228_2 - 9.9e-28 96.8 8.0 3.5e-26 91.7 3.3 2.1 2 0 0 2 2 2 2 Tektin family Tektin PF03148.12 T383228_3 - 6.8e-05 21.7 0.0 0.0001 21.1 0.0 1.1 1 0 0 1 1 1 1 Tektin family DUF1725 PF08333.9 T182465_1 - 0.046 13.3 0.5 0.09 12.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T344412_1 - 6.3e-33 114.0 0.3 1.1e-32 113.1 0.3 1.4 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T344412_2 - 6.4e-32 110.7 0.3 1.1e-31 109.9 0.3 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T344412_3 - 2.1e-34 118.9 13.4 2e-33 115.6 4.7 2.5 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T314344_1 - 0.051 13.1 1.2 0.14 11.8 1.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) SspN PF08177.9 T276597_3 - 1.2 9.1 33.1 43 4.1 0.2 10.8 3 3 7 12 12 12 0 Small acid-soluble spore protein N family DUF4567 PF15131.4 T247036_2 - 3e-44 149.1 3.5 5e-44 148.4 3.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4567) DUF1725 PF08333.9 T012472_1 - 7.6e-07 28.5 0.2 1.5e-06 27.5 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T012472_2 - 6.9e-07 28.9 3.0 1.9e-06 27.4 0.0 2.4 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T012472_3 - 3.5e-07 29.8 0.1 5.7e-07 29.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CENP-B_dimeris PF09026.8 T040789_1 - 0.34 11.2 9.7 0.58 10.4 9.7 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DDHD PF02862.15 T040789_1 - 0.47 10.4 12.1 0.63 10.0 12.1 1.2 1 0 0 1 1 1 0 DDHD domain BUD22 PF09073.8 T040789_1 - 4.5 6.4 42.1 7.8 5.6 42.1 1.3 1 0 0 1 1 1 0 BUD22 Connexin PF00029.17 T040789_2 - 0.024 14.3 1.3 0.036 13.7 1.3 1.2 1 0 0 1 1 1 0 Connexin Eapp_C PF10238.7 T040789_2 - 0.5 10.3 5.4 0.91 9.5 5.4 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein RR_TM4-6 PF06459.10 T040789_2 - 1.7 8.3 7.8 2.2 7.9 7.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TT_ORF1 PF02956.12 T040789_3 - 0.19 10.3 31.8 0.24 9.9 31.8 1.1 1 0 0 1 1 1 0 TT viral orf 1 CDC45 PF02724.12 T040789_3 - 0.38 8.9 34.1 0.47 8.6 34.1 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM27 PF15832.3 T215853_1 - 2.7e-36 123.8 24.5 2.7e-36 123.8 24.5 1.8 2 0 0 2 2 2 1 FAM27 D and E protein family RNase_H PF00075.22 T171328_1 - 0.019 15.0 0.0 0.03 14.4 0.0 1.2 1 0 0 1 1 1 0 RNase H TLV_coat PF00429.17 T171328_2 - 7e-99 331.9 3.5 9.3e-99 331.5 3.5 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Transposase_22 PF02994.12 T171284_3 - 1.8e-116 388.9 16.5 2.7e-116 388.3 16.5 1.2 1 0 0 1 1 1 1 L1 transposable element ATG16 PF08614.9 T171284_3 - 1.1 9.3 5.1 1.9 8.5 5.1 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) CENP-B_dimeris PF09026.8 T102653_3 - 0.19 12.0 0.1 0.35 11.1 0.1 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain POM121 PF15229.4 T361772_2 - 3.9e-24 85.6 5.8 1.2e-23 84.0 5.8 1.7 1 0 0 1 1 1 1 POM121 family Sec3-PIP2_bind PF15277.4 T265032_3 - 6e-18 64.7 0.3 8.7e-18 64.1 0.3 1.2 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH CCDC144C PF14915.4 T018735_1 - 6.8e-61 205.9 37.8 5.4e-36 124.1 14.1 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018735_1 - 0.0091 15.9 1.1 0.0091 15.9 1.1 2.9 3 0 0 3 3 3 1 Laminin Domain II CCDC144C PF14915.4 T018735_2 - 8.6e-17 61.1 9.6 8.6e-17 61.1 9.6 1.5 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018735_2 - 5.7e-09 36.2 0.0 5.7e-09 36.2 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3496) DUF3496 PF12001.6 T018735_3 - 8.6e-17 61.4 7.5 1.8e-16 60.3 7.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3496) NPR2 PF06218.9 T212037_1 - 0.023 13.4 0.1 0.031 13.0 0.1 1.1 1 0 0 1 1 1 0 Nitrogen permease regulator 2 Transposase_22 PF02994.12 T325381_1 - 2.5e-128 427.9 28.4 8.1e-128 426.2 28.4 1.7 1 1 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T325381_1 - 1.6e-17 63.6 0.6 3.2e-17 62.6 0.6 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T325381_1 - 3.2e-08 32.9 0.7 7.3e-08 31.7 0.7 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos PF03372.21 T325381_1 - 2.2e-07 31.0 0.0 4.2e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T325381_1 - 3e-07 30.2 0.9 8.3e-07 28.8 0.9 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Seryl_tRNA_N PF02403.20 T325381_1 - 0.037 14.1 5.2 0.083 13.0 5.2 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain XhlA PF10779.7 T325381_1 - 7.3 6.7 9.0 0.72 9.9 2.9 2.3 2 0 0 2 2 2 0 Haemolysin XhlA Gag_p30 PF02093.14 T325381_2 - 1.4e-11 44.2 0.1 3.3e-11 43.0 0.1 1.6 1 1 0 1 1 1 1 Gag P30 core shell protein zf-CCHC PF00098.21 T325381_2 - 0.0017 18.2 0.7 0.0049 16.8 0.7 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.4 T325381_2 - 1.9 8.2 6.4 0.46 10.2 1.9 2.4 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.25 T325381_3 - 2.9e-24 85.7 0.1 5.4e-24 84.8 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NPIP PF06409.9 T374804_3 - 6.1e-05 22.2 0.5 9.8e-05 21.6 0.5 1.2 1 0 0 1 1 1 1 Nuclear pore complex interacting protein (NPIP) RVT_1 PF00078.25 T291133_2 - 8.1e-46 156.2 2.5 1.3e-45 155.5 2.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSBP1 PF06825.10 T291133_2 - 0.0008 19.2 1.0 0.0017 18.1 1.0 1.6 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Transposase_22 PF02994.12 T103720_2 - 2.1e-142 474.2 20.5 2.9e-142 473.8 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103720_2 - 0.03 14.5 0.0 0.056 13.6 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103720_2 - 0.059 13.0 10.5 0.11 12.2 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103720_2 - 0.06 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103720_2 - 0.34 11.3 5.0 0.69 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103720_2 - 0.42 9.8 12.3 0.74 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103720_2 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103720_2 - 3 8.0 7.5 5.3 7.2 6.7 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Transposase_22 PF02994.12 T266522_1 - 1.6e-55 188.3 0.4 2.2e-55 187.9 0.4 1.1 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T266522_2 - 1.9e-13 49.9 0.7 2.7e-13 49.4 0.7 1.1 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T266522_3 - 1.1e-30 106.6 1.7 1.9e-30 105.9 1.7 1.3 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T266522_3 - 1.1e-10 41.7 0.0 2.3e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T266522_3 - 5e-10 39.1 2.4 6.8e-10 38.7 1.4 1.8 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Flu_C_NS2 PF03555.12 T138153_2 - 0.34 11.0 1.9 89 3.2 0.0 3.8 4 0 0 4 4 4 0 Influenza C non-structural protein (NS2) DUF2784 PF10861.6 T366712_1 - 0.16 11.8 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of Unknown function (DUF2784) zf-C3H1 PF10650.7 T366712_1 - 1.6 8.4 6.9 5.2 6.8 0.9 2.8 2 0 0 2 2 2 0 Putative zinc-finger domain Trypan_PARP PF05887.9 T278160_1 - 0.62 10.0 23.1 0.48 10.3 7.7 2.4 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) Neisseria_TspB PF05616.11 T278160_2 - 0.46 8.8 1.3 0.85 7.9 1.3 1.3 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Trypan_PARP PF05887.9 T278160_2 - 3.4 7.5 18.5 0.04 13.8 7.9 2.4 3 0 0 3 3 3 0 Procyclic acidic repetitive protein (PARP) DUF1777 PF08648.10 T035457_2 - 0.87 9.7 41.4 1.2 9.2 28.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) Bactofilin PF04519.11 T035457_3 - 0.64 10.2 26.8 0.72 10.0 4.8 2.8 2 1 0 2 2 2 0 Polymer-forming cytoskeletal Transposase_22 PF02994.12 T171285_3 - 1.5e-116 389.1 16.5 2.3e-116 388.5 16.5 1.2 1 0 0 1 1 1 1 L1 transposable element ATG16 PF08614.9 T171285_3 - 0.91 9.5 5.1 1.6 8.7 5.1 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) WAP PF00095.19 T073913_1 - 0.00032 20.9 11.7 0.0027 17.9 11.7 2.2 1 1 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' DUF2600 PF10776.7 T236685_1 - 0.35 9.5 21.4 0.096 11.4 0.8 4.8 3 2 2 5 5 5 0 Protein of unknown function (DUF2600) TPR_16 PF13432.4 T035019_1 - 0.0078 16.8 0.1 13 6.4 0.0 3.7 2 1 2 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.4 T035019_2 - 0.054 14.1 0.4 22 5.7 0.0 3.1 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.4 T035019_3 - 0.0069 16.9 2.1 4.2 8.0 0.1 3.7 1 1 2 4 4 4 3 Tetratricopeptide repeat Nop53 PF07767.9 T097219_1 - 1.6 8.0 56.5 2.5 7.3 56.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Presenilin PF01080.15 T097219_1 - 9.3 4.7 25.1 15 4.1 25.1 1.2 1 0 0 1 1 1 0 Presenilin Presenilin PF01080.15 T097219_3 - 0.0013 17.4 15.5 0.0023 16.6 15.5 1.3 1 0 0 1 1 1 1 Presenilin TMEM238 PF15125.4 T141809_3 - 4.1e-25 87.6 6.7 6.5e-25 86.9 6.7 1.3 1 0 0 1 1 1 1 TMEM238 protein family Phage_holin_3_6 PF07332.9 T141809_3 - 1 9.3 5.7 1.7 8.6 5.7 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III RNA_pol_Rpb1_R PF05001.11 T155843_1 - 6.3 7.2 13.7 23 5.5 2.3 4.2 2 0 0 2 2 2 0 RNA polymerase Rpb1 C-terminal repeat RNase_H PF00075.22 T294828_1 - 4.1e-07 30.2 0.0 7.2e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T318967_1 - 4.4e-42 144.0 2.3 6.5e-42 143.4 2.3 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAM27 PF15832.3 T166225_2 - 8.1 6.9 14.7 25 5.4 3.5 5.1 2 1 2 5 5 5 0 FAM27 D and E protein family DUF1725 PF08333.9 T253053_1 - 2.6e-08 33.2 0.3 2.6e-08 33.2 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) zf-H2C2_2 PF13465.4 T194081_3 - 1e-75 246.9 71.7 1.6e-08 34.5 0.5 12.0 12 0 0 12 12 12 10 Zinc-finger double domain zf-C2H2 PF00096.24 T194081_3 - 5.5e-55 180.7 68.6 1.5e-06 28.2 2.1 11.3 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T194081_3 - 2.4e-24 83.8 66.4 0.0028 18.2 1.2 11.6 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T194081_3 - 1e-12 47.5 60.1 0.0038 17.0 1.5 11.0 10 0 0 10 10 10 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T194081_3 - 5.7e-07 29.4 48.3 0.045 13.8 2.7 6.9 3 2 4 8 8 8 7 Zinc ribbon domain XPA_N PF01286.16 T194081_3 - 1.5e-05 24.7 41.8 1.2 9.0 0.2 10.6 10 0 0 10 10 10 4 XPA protein N-terminal zf-C2H2_11 PF16622.3 T194081_3 - 0.28 10.9 42.4 0.61 9.8 0.7 9.2 9 0 0 9 9 9 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 T194081_3 - 0.45 11.2 41.7 0.32 11.6 3.6 5.6 1 1 4 5 5 5 0 zinc-ribbon family Cyt-b5 PF00173.26 T058842_3 - 1.2e-12 47.6 0.0 2.4e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PQ-loop PF04193.12 T128891_3 - 0.064 12.9 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 PQ loop repeat rve PF00665.24 T082825_1 - 9.8e-15 54.7 0.0 1.5e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.21 T082825_1 - 0.0054 16.6 3.0 0.021 14.8 3.0 2.1 1 0 0 1 1 1 1 Zinc knuckle RNase_H PF00075.22 T082825_1 - 0.0068 16.5 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 RNase H RNase_H PF00075.22 T082825_2 - 5.2e-07 29.8 0.0 8.2e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T082825_3 - 7.7e-07 28.7 0.0 1.3e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein zf-H2C2 PF09337.8 T082825_3 - 0.0021 18.1 0.7 0.0058 16.8 0.7 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger TPR_4 PF07721.12 T058257_2 - 0.078 13.5 0.3 0.28 11.8 0.3 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat rve PF00665.24 T338695_2 - 5.9e-23 81.2 0.0 1.2e-22 80.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T338695_2 - 3.6e-09 36.8 0.0 6.3e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 RNase H DDE_Tnp_IS240 PF13610.4 T338695_2 - 0.012 15.7 0.0 0.018 15.1 0.0 1.2 1 0 0 1 1 1 0 DDE domain IN_DBD_C PF00552.19 T338695_3 - 5.6e-07 28.6 0.4 5.6e-07 28.6 0.4 1.7 2 0 0 2 2 2 1 Integrase DNA binding domain GP41 PF00517.15 T338695_3 - 0.00039 20.2 0.2 0.00039 20.2 0.2 2.2 3 0 0 3 3 3 1 Retroviral envelope protein rve PF00665.24 T338695_3 - 0.00066 19.7 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Borrelia_orfX PF04160.10 T338695_3 - 0.012 15.5 0.6 0.03 14.2 0.6 1.6 1 0 0 1 1 1 0 Orf-X protein CAP_N PF01213.17 T036617_2 - 1.5 8.1 6.5 2.6 7.3 6.5 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal rve PF00665.24 T112510_3 - 2e-08 34.3 0.0 3.5e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain dUTPase PF00692.17 T112510_3 - 4.6e-08 32.7 0.0 8e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 dUTPase DUF1725 PF08333.9 T074394_1 - 6.5e-13 47.8 13.7 1.7e-08 33.7 0.8 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF1725) Terpene_synth PF01397.19 T074394_2 - 0.069 12.7 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain DUF4705 PF15788.3 T322050_1 - 1.9e-46 155.9 253.2 2.5e-18 65.9 10.8 21.1 12 5 7 20 20 20 15 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322050_2 - 4.7e-08 33.0 213.5 0.0031 17.6 6.0 20.4 14 4 3 17 17 17 10 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322050_3 - 1.8e-28 98.4 218.0 2e-14 53.4 12.6 19.6 5 4 11 16 16 16 8 Domain of unknown function (DUF4705) Gag_p30 PF02093.14 T065986_1 - 5.8e-16 58.5 0.0 9e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T065986_1 - 0.085 13.0 0.0 0.82 9.9 0.0 2.2 2 0 0 2 2 2 0 Retroviral aspartyl protease RNase_H PF00075.22 T065986_2 - 3.7e-17 62.7 0.0 6.5e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 RNase H rve PF00665.24 T065986_2 - 1.5e-05 25.1 0.0 2.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T065986_2 - 0.024 14.0 0.1 0.069 12.5 0.1 1.7 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T065986_3 - 0.00026 20.5 0.0 0.00041 19.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T307844_1 - 6.4e-14 51.9 0.0 1.2e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.4 T307844_1 - 0.013 16.0 0.0 0.023 15.3 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T307844_1 - 0.016 15.6 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-C2H2_10 PF16588.3 T307844_1 - 0.41 10.3 5.4 0.068 12.8 0.8 2.2 2 0 0 2 2 2 0 C2H2 zinc-finger zf-CCHC PF00098.21 T307844_1 - 0.78 9.8 9.8 0.022 14.7 3.0 2.1 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.25 T307844_2 - 1.8e-24 86.4 0.4 5.4e-11 42.3 0.0 2.2 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T307844_3 - 6.9e-06 25.6 0.0 1.1e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4641 PF15483.4 T376197_2 - 4.5e-40 138.0 3.1 5.9e-40 137.6 3.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4641) DUF1510 PF07423.9 T338637_1 - 0.018 14.4 17.1 0.024 13.9 17.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) NPR3 PF03666.11 T338637_1 - 0.21 10.2 21.4 0.29 9.7 21.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1510 PF07423.9 T338637_2 - 0.024 14.0 17.6 0.036 13.4 17.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Presenilin PF01080.15 T338637_2 - 4.4 5.8 21.3 5.9 5.4 21.3 1.1 1 0 0 1 1 1 0 Presenilin Transposase_22 PF02994.12 T372539_2 - 4.8e-19 68.3 0.1 7.1e-19 67.8 0.1 1.2 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T372539_3 - 1.3e-70 238.0 24.8 1.3e-69 234.7 24.8 2.1 1 1 0 1 1 1 1 L1 transposable element Syntaxin-6_N PF09177.9 T372539_3 - 0.12 12.8 12.6 0.017 15.5 8.1 1.9 2 0 0 2 2 2 0 Syntaxin 6, N-terminal CorA PF01544.16 T372539_3 - 0.19 10.9 6.3 0.27 10.4 6.3 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF1664 PF07889.10 T372539_3 - 0.32 10.9 2.9 0.6 10.0 2.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ABC_tran_CTD PF16326.3 T372539_3 - 0.72 10.0 8.0 1.8 8.7 8.0 1.6 1 0 0 1 1 1 0 ABC transporter C-terminal domain Gag_p24 PF00607.18 T336594_1 - 1e-39 136.4 0.0 1.4e-39 136.0 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) Integrase_Zn PF02022.17 T336594_1 - 4.9e-14 51.9 2.3 1.4e-13 50.4 2.3 1.9 1 0 0 1 1 1 1 Integrase Zinc binding domain RNase_H PF00075.22 T336594_1 - 1.7e-12 47.6 0.0 2.8e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T336594_1 - 3e-07 30.1 0.0 4.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T336594_1 - 0.00019 21.5 0.0 0.00035 20.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.21 T336594_1 - 0.00095 19.0 6.2 0.0048 16.8 6.2 2.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.4 T336594_1 - 0.1 12.2 2.5 0.24 11.0 2.5 1.6 1 0 0 1 1 1 0 Zinc knuckle RVP PF00077.18 T336594_2 - 1.9e-24 85.7 0.1 3.7e-24 84.8 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease dUTPase PF00692.17 T336594_2 - 1e-19 70.3 0.0 1.7e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 dUTPase G-patch PF01585.21 T336594_2 - 1.7e-07 30.9 1.1 3.6e-07 29.9 1.1 1.5 1 0 0 1 1 1 1 G-patch domain gag-asp_proteas PF13975.4 T336594_2 - 0.096 13.1 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_5 PF14787.4 T336594_3 - 1.9e-14 52.9 1.0 6e-14 51.3 1.0 1.9 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger rve PF00665.24 T336594_3 - 5.6e-08 32.9 0.0 9.7e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain IN_DBD_C PF00552.19 T336594_3 - 9.8e-08 31.0 2.6 2e-07 30.1 2.6 1.5 1 0 0 1 1 1 1 Integrase DNA binding domain HERV-K_REC PF15695.3 T336594_3 - 0.0045 16.9 0.2 0.0081 16.1 0.2 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Transposase_1 PF01359.16 T021185_2 - 3.4e-05 23.5 0.0 6e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T021185_3 - 2.9e-23 81.4 1.6 5.3e-23 80.6 1.6 1.4 1 0 0 1 1 1 1 Transposase (partial DDE domain) Pox_Ag35 PF03286.12 T021185_3 - 0.07 12.8 0.3 0.11 12.1 0.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Transposase_1 PF01359.16 T261600_2 - 4.6e-08 32.7 0.0 8.8e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T261600_3 - 1.5e-12 47.0 0.2 4.3e-12 45.6 0.2 1.8 1 0 0 1 1 1 1 Transposase (partial DDE domain) HTH_Mga PF08280.9 T316856_2 - 6.3 6.8 8.4 21 5.1 0.1 3.7 4 0 0 4 4 4 0 M protein trans-acting positive regulator (MGA) HTH domain SlyX PF04102.10 T288554_1 - 0.047 14.2 20.9 0.18 12.3 1.9 3.5 2 1 1 3 3 3 0 SlyX PspA_IM30 PF04012.10 T288554_1 - 0.69 9.3 25.4 0.033 13.6 1.3 3.1 2 1 1 3 3 3 0 PspA/IM30 family HrpB7 PF09486.8 T288554_1 - 2.1 8.6 8.8 6.5 7.0 0.2 3.1 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Fib_alpha PF08702.8 T288554_1 - 9.3 6.3 16.8 12 5.9 9.6 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family RVT_1 PF00078.25 T346320_2 - 2.1e-07 30.6 0.0 3.2e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4705 PF15788.3 T323229_1 - 0.0096 16.0 15.5 0.0096 16.0 15.5 5.5 4 1 1 5 5 5 2 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323229_2 - 5.5 7.2 32.7 0.47 10.6 5.5 4.1 2 1 2 4 4 4 0 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323229_3 - 2e-06 27.8 22.1 0.00012 22.1 6.2 7.0 5 2 2 7 7 7 2 Domain of unknown function (DUF4705) DUF3915 PF13054.4 T089730_1 - 0.66 9.8 4.0 1.3 8.9 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 T089730_2 - 0.021 14.7 6.3 0.039 13.8 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Dynein_heavy PF03028.13 T085619_2 - 5.8e-11 41.2 0.0 8.4e-11 40.7 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DUF1725 PF08333.9 T085619_3 - 0.00018 20.9 0.5 0.00038 19.9 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) PHO4 PF01384.18 T085619_3 - 0.0044 16.0 5.0 0.0078 15.2 5.0 1.3 1 0 0 1 1 1 1 Phosphate transporter family Methyltransf_6 PF03737.13 T374601_1 - 0.16 12.0 0.0 0.27 11.3 0.0 1.2 1 0 0 1 1 1 0 Demethylmenaquinone methyltransferase Gag_p30 PF02093.14 T374601_2 - 3.3e-52 176.9 0.9 4.9e-52 176.4 0.9 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein rve PF00665.24 T374601_2 - 5.3e-14 52.3 0.0 1e-13 51.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.18 T374601_2 - 2e-13 50.3 0.0 3.7e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.8 T374601_2 - 1.6e-06 28.1 0.2 4.2e-06 26.8 0.2 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RNase_H PF00075.22 T374601_2 - 9.6e-05 22.5 0.0 0.00018 21.6 0.0 1.3 1 0 0 1 1 1 1 RNase H Asp_protease_2 PF13650.4 T374601_2 - 0.041 14.4 0.0 0.076 13.6 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T374601_2 - 0.047 14.1 0.0 0.09 13.2 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVT_1 PF00078.25 T374601_3 - 1.1e-10 41.3 0.0 1.7e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_MA PF01140.17 T374601_3 - 4.8e-09 35.9 0.1 8.2e-09 35.1 0.1 1.3 1 0 0 1 1 1 1 Matrix protein (MA), p15 DUF4705 PF15788.3 T325787_1 - 1.5e-27 95.4 434.2 4.1e-09 36.4 14.3 36.1 18 8 13 32 32 32 22 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T325787_2 - 1.7e-19 69.6 394.5 2e-07 31.0 7.6 33.8 18 7 11 31 31 31 21 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T325787_3 - 1.8e-25 88.7 413.1 3.7e-07 30.1 0.2 35.2 22 13 8 30 30 30 20 Domain of unknown function (DUF4705) BmKX PF09132.8 T137775_1 - 0.058 13.3 8.7 1.1e+02 2.7 0.0 6.2 6 0 0 6 6 6 0 BmKX DUF3903 PF13043.4 T137775_1 - 0.75 9.6 4.9 1.8e+02 2.0 0.0 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF3903) BmKX PF09132.8 T137775_2 - 0.032 14.1 0.3 1.1e+02 2.7 0.0 4.5 4 0 0 4 4 4 0 BmKX BmKX PF09132.8 T137775_3 - 0.018 14.9 4.6 1.3e+02 2.5 0.1 5.7 6 0 0 6 6 6 0 BmKX Filament PF00038.19 T078929_1 - 3.4e-40 138.4 14.0 4.4e-40 138.1 14.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein CALCOCO1 PF07888.9 T078929_1 - 1 7.7 11.7 1.4 7.3 11.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.9 T078929_1 - 1.1 8.0 9.9 1.8 7.2 9.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein BRE1 PF08647.9 T078929_1 - 1.8 8.6 10.2 1.4 8.9 3.0 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Tropomyosin_1 PF12718.5 T078929_1 - 7.5 6.5 12.9 12 5.9 12.9 1.1 1 0 0 1 1 1 0 Tropomyosin like Transposase_1 PF01359.16 T069603_3 - 5.8e-18 64.4 0.2 5.8e-18 64.4 0.2 2.2 2 0 0 2 2 2 1 Transposase (partial DDE domain) AMPKBI PF04739.13 T183090_2 - 0.0028 17.8 2.0 13 6.0 0.0 3.3 3 0 0 3 3 3 3 5'-AMP-activated protein kinase beta subunit, interaction domain Colipase-like PF15083.4 T090313_3 - 2.3e-32 110.8 11.3 4.5e-32 109.9 11.3 1.4 1 0 0 1 1 1 1 Colipase-like Raffinose_syn PF05691.10 T276642_1 - 0.00093 17.0 3.4 4.5 4.8 0.0 5.4 5 2 0 7 7 7 3 Raffinose synthase or seed imbibition protein Sip1 Peptidase_M41 PF01434.16 T276642_1 - 0.18 11.3 2.0 38 3.7 0.0 4.8 4 2 2 6 6 6 0 Peptidase family M41 DUF759 PF05537.9 T276642_2 - 0.011 14.6 0.2 58 2.3 0.0 5.1 6 0 0 6 6 6 0 Borrelia burgdorferi protein of unknown function (DUF759) Raffinose_syn PF05691.10 T276642_2 - 0.089 10.4 0.5 4.5 4.8 0.0 3.8 4 1 0 5 5 5 0 Raffinose synthase or seed imbibition protein Sip1 Pentapeptide_4 PF13599.4 T358912_1 - 6.4e-12 45.3 5.4 1.6e-05 24.8 2.2 3.4 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) CD225 PF04505.10 T367907_1 - 1.2e-20 73.2 2.1 1.3e-19 69.9 0.1 2.8 2 0 0 2 2 2 1 Interferon-induced transmembrane protein Haemolytic PF01809.16 T091415_1 - 0.022 14.5 0.0 0.062 13.0 0.0 1.7 1 0 0 1 1 1 0 Haemolytic domain Transposase_22 PF02994.12 T310786_3 - 1.3e-148 494.7 27.5 7e-122 406.7 12.0 2.1 2 0 0 2 2 2 2 L1 transposable element DUF4613 PF15390.4 T310786_3 - 0.14 10.3 4.9 0.21 9.8 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) IncA PF04156.12 T310786_3 - 0.34 10.6 11.9 0.73 9.5 11.9 1.5 1 0 0 1 1 1 0 IncA protein Pentapeptide_4 PF13599.4 T358909_2 - 4.7e-12 45.7 5.4 1.4e-05 24.9 2.2 3.4 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) zf-CCHC PF00098.21 T256961_1 - 0.00013 21.7 2.5 0.00013 21.7 2.5 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T256961_1 - 3.5 7.3 7.9 0.87 9.2 2.1 2.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Gag_p30 PF02093.14 T256961_2 - 0.026 13.9 0.0 0.041 13.3 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein POM121 PF15229.4 T361770_2 - 3.6e-24 85.7 5.8 1.1e-23 84.1 5.8 1.8 1 0 0 1 1 1 1 POM121 family ubiquitin PF00240.21 T166772_2 - 0.00065 19.2 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF4573 PF15140.4 T258340_1 - 0.2 11.3 3.8 0.36 10.5 2.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4573) DUF4573 PF15140.4 T258340_2 - 4.6e-05 23.2 24.6 0.00079 19.1 12.7 3.1 1 1 2 3 3 3 2 Domain of unknown function (DUF4573) DUF4573 PF15140.4 T258340_3 - 0.0053 16.5 13.4 0.03 14.0 12.1 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4573) Flot PF15975.3 T258340_3 - 0.48 10.5 43.2 2.2 8.3 3.6 4.5 1 1 3 4 4 4 0 Flotillin HTH_Mga PF08280.9 T316859_2 - 8.6 6.4 9.9 40 4.2 0.4 4.3 4 0 0 4 4 4 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_Tnp_Tc5 PF03221.14 T245953_1 - 0.00036 20.4 0.3 0.00062 19.6 0.3 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.11 T245953_3 - 0.00089 18.7 0.4 0.0023 17.4 0.4 1.7 1 1 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Gag_p30 PF02093.14 T297827_3 - 0.00032 20.1 0.0 0.00053 19.4 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T297827_3 - 0.0094 15.3 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) APG6 PF04111.10 T326333_3 - 0.26 10.5 5.6 0.35 10.1 5.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 T326333_3 - 0.31 10.7 7.3 0.44 10.2 7.3 1.2 1 0 0 1 1 1 0 IncA protein OmpH PF03938.12 T326333_3 - 0.33 10.8 6.4 0.51 10.2 6.4 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF972 PF06156.11 T326333_3 - 0.81 10.2 3.6 1.2 9.7 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF1028 PF06267.10 T258985_3 - 5.1 6.7 6.6 9.8 5.8 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) LSPR PF06049.10 T352722_1 - 0.055 13.2 3.1 30 4.9 0.1 6.3 2 1 1 3 3 3 0 Coagulation Factor V LSPD Repeat Ephrin_rec_like PF07699.11 T352722_2 - 0.52 10.0 5.5 4.9 6.9 0.4 4.0 3 0 0 3 3 3 0 Putative ephrin-receptor like UPAR_LY6 PF00021.19 T353222_2 - 4.5e-06 27.1 6.1 1.3e-05 25.7 6.1 1.8 1 0 0 1 1 1 1 u-PAR/Ly-6 domain PRP9_N PF16958.3 T316680_3 - 3 7.7 6.4 4.6 7.1 6.4 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus TFIIA PF03153.11 T358011_1 - 5.7 6.7 12.2 9.6 5.9 12.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pentapeptide_4 PF13599.4 T000081_1 - 5.8e-09 35.8 4.8 0.25 11.3 0.0 9.1 9 4 1 10 10 10 4 Pentapeptide repeats (9 copies) Lamprin PF06403.9 T000081_1 - 0.13 12.1 0.0 11 5.8 0.1 3.5 4 0 0 4 4 4 0 Lamprin Pentapeptide_4 PF13599.4 T000081_2 - 3.1e-10 39.9 3.4 18 5.4 0.0 10.1 8 2 0 8 8 8 4 Pentapeptide repeats (9 copies) Lamprin PF06403.9 T000081_2 - 0.15 11.9 0.2 0.55 10.1 0.2 1.9 2 0 0 2 2 2 0 Lamprin Chorion_1 PF01723.14 T000081_2 - 1.3 8.8 4.7 2.9 7.7 4.7 1.5 1 0 0 1 1 1 0 Chorion protein Septin PF00735.16 T000081_3 - 0.00068 18.8 0.0 0.00096 18.3 0.0 1.1 1 0 0 1 1 1 1 Septin Lamprin PF06403.9 T000081_3 - 0.29 10.9 4.2 1.1e+02 2.5 0.0 6.1 8 0 0 8 8 8 0 Lamprin DUF2956 PF11169.6 T294565_2 - 0.46 10.6 9.4 1.2 9.3 9.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) DUF4366 PF14283.4 T294565_3 - 0.65 9.3 1.4 1 8.7 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Transposase_22 PF02994.12 T346736_2 - 6.3e-64 216.0 8.9 2.2e-57 194.5 5.4 2.2 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T346736_3 - 4.2e-35 121.1 1.9 7.3e-35 120.3 1.9 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T346736_3 - 6e-14 51.5 14.6 2.9e-07 29.6 2.9 2.2 2 0 0 2 2 2 2 L1 transposable element HSBP1 PF06825.10 T346736_3 - 0.028 14.2 0.1 0.064 13.0 0.1 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 NPIP PF06409.9 T374803_3 - 6.1e-05 22.2 0.5 9.9e-05 21.5 0.5 1.2 1 0 0 1 1 1 1 Nuclear pore complex interacting protein (NPIP) Epiglycanin_C PF14654.4 T300740_1 - 4.6e-09 36.1 0.7 8.8e-09 35.2 0.7 1.4 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300740_1 - 2.6e-06 27.3 4.4 6e-06 26.1 4.4 1.6 1 0 0 1 1 1 1 Mucin-like Mucin-like PF16058.3 T300740_3 - 0.023 14.6 5.9 0.056 13.4 5.9 1.7 1 0 0 1 1 1 0 Mucin-like Herpes_LMP1 PF05297.9 T300740_3 - 8.3 5.4 8.4 13 4.7 8.4 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Gag_p30 PF02093.14 T065984_1 - 0.00031 20.2 0.0 0.00049 19.5 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p30 PF02093.14 T065984_2 - 7e-16 58.2 0.0 1.1e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T065984_2 - 0.11 12.7 0.0 0.98 9.6 0.0 2.2 2 0 0 2 2 2 0 Retroviral aspartyl protease RNase_H PF00075.22 T065984_3 - 4.6e-17 62.4 0.0 7.9e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 RNase H rve PF00665.24 T065984_3 - 1.8e-05 24.8 0.0 3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T065984_3 - 0.031 13.7 0.1 0.081 12.3 0.1 1.7 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Lamprin PF06403.9 T052991_1 - 2.3 8.0 32.2 0.25 11.2 7.7 3.6 3 0 0 3 3 3 0 Lamprin Lamprin PF06403.9 T052991_3 - 3.6 7.4 28.4 0.072 12.9 3.6 3.6 2 1 0 2 2 2 0 Lamprin DUF678 PF05077.10 T258954_1 - 2.5 8.2 5.7 0.81 9.7 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF678) Transposase_22 PF02994.12 T258954_2 - 0.00062 18.6 0.0 0.00099 17.9 0.0 1.2 1 0 0 1 1 1 1 L1 transposable element DUF4641 PF15483.4 T376189_1 - 7.5e-176 585.5 18.5 7.5e-176 585.5 18.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4641) Collagen_mid PF15984.3 T044791_2 - 7.7 6.1 6.0 3.7 7.1 0.8 2.3 2 0 0 2 2 2 0 Bacterial collagen, middle region TMEM191C PF15194.4 T230008_1 - 4.4e-27 94.5 8.2 7.8e-27 93.7 8.2 1.4 1 0 0 1 1 1 1 TMEM191C family TMCO5 PF14992.4 T230008_1 - 3.8 6.9 7.7 0.44 10.0 0.4 2.0 2 0 0 2 2 2 0 TMCO5 family TMEM191C PF15194.4 T230008_2 - 2.3e-12 47.0 0.1 4.8e-12 45.9 0.1 1.4 1 0 0 1 1 1 1 TMEM191C family UPAR_LY6 PF00021.19 T176635_1 - 2.1e-06 28.2 25.8 0.00082 19.9 5.5 3.6 3 0 0 3 3 3 3 u-PAR/Ly-6 domain HTH_Mga PF08280.9 T316854_2 - 7.8 6.5 8.4 21 5.1 0.1 3.6 4 0 0 4 4 4 0 M protein trans-acting positive regulator (MGA) HTH domain RAMP4 PF06624.10 T000051_3 - 0.054 13.4 0.4 1.5e+02 2.4 0.0 4.9 6 0 0 6 6 6 0 Ribosome associated membrane protein RAMP4 rve PF00665.24 T023858_1 - 1.8e-14 53.8 0.0 2.8e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain dUTPase PF00692.17 T023858_3 - 4.8e-14 52.0 0.0 7.5e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 dUTPase Circo_capsid PF02443.13 T027370_1 - 5.1 6.5 10.1 7.4 5.9 10.1 1.1 1 0 0 1 1 1 0 Circovirus capsid protein DUF1725 PF08333.9 T136204_1 - 0.0019 17.7 1.2 0.0036 16.8 1.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) GAIN PF16489.3 T229027_1 - 2.3e-10 40.1 0.0 3.3e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.19 T229027_2 - 0.00076 20.0 0.2 0.013 16.0 0.1 2.8 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif RVT_1 PF00078.25 T292095_2 - 5.2e-43 147.0 2.3 7.9e-43 146.4 2.3 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1510 PF07423.9 T362221_1 - 0.001 18.5 9.8 0.0016 17.8 9.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) Methyltransf_32 PF13679.4 T362221_1 - 0.65 9.8 6.8 1.2 9.0 6.8 1.3 1 0 0 1 1 1 0 Methyltransferase domain Afi1 PF07792.10 T362221_1 - 0.65 10.3 10.7 1.2 9.5 10.7 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Pentapeptide_4 PF13599.4 T131393_1 - 1.5e-08 34.5 0.0 0.09 12.8 0.0 3.8 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T131393_3 - 0.00016 21.6 0.0 4.8 7.2 0.0 3.8 3 1 1 4 4 4 3 Pentapeptide repeats (9 copies) Gag_p24 PF00607.18 T274833_1 - 9.6e-27 94.0 0.0 1.4e-26 93.5 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) dUTPase PF00692.17 T274833_1 - 1.3e-19 70.0 0.0 3.6e-18 65.4 0.0 2.2 2 0 0 2 2 2 1 dUTPase Transposase_22 PF02994.12 T274833_1 - 2.9e-06 26.3 3.8 4.1e-06 25.8 3.8 1.1 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T274833_1 - 8.2e-05 22.1 0.0 0.00013 21.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_5 PF14787.4 T274833_2 - 2.1e-06 27.2 19.2 5.3e-06 25.9 8.7 3.2 2 1 0 2 2 2 2 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.21 T274833_2 - 0.00071 19.4 6.8 0.0043 16.9 6.2 2.9 2 0 0 2 2 2 1 Zinc knuckle RNase_H PF00075.22 T274833_2 - 0.045 13.8 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 RNase H RVT_1 PF00078.25 T274833_3 - 1.1e-24 87.1 0.3 3.3e-13 49.5 0.1 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.12 T274833_3 - 1.6e-24 85.2 0.6 4e-24 84.0 0.6 1.7 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVP PF00077.18 T274833_3 - 2e-20 72.8 0.0 4.3e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T274833_3 - 2.1e-18 66.5 0.0 4e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Gag_p10 PF02337.15 T274833_3 - 4.7e-14 51.9 0.2 1.1e-13 50.7 0.2 1.6 1 0 0 1 1 1 1 Retroviral GAG p10 protein Gag_p24 PF00607.18 T274833_3 - 2.3e-12 47.1 0.2 4.6e-12 46.1 0.2 1.5 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) GP41 PF00517.15 T274833_3 - 2.7e-12 46.8 0.5 5.1e-12 45.9 0.5 1.4 1 0 0 1 1 1 1 Retroviral envelope protein RNase_H PF00075.22 T274833_3 - 8.2e-11 42.1 0.1 8.2e-11 42.1 0.1 1.6 2 0 0 2 2 1 1 RNase H G-patch PF01585.21 T274833_3 - 9.7e-09 34.9 2.2 2.1e-08 33.8 2.2 1.5 1 0 0 1 1 1 1 G-patch domain Integrase_Zn PF02022.17 T274833_3 - 0.0008 19.2 1.5 0.0027 17.5 1.5 2.0 1 0 0 1 1 1 1 Integrase Zinc binding domain IN_DBD_C PF00552.19 T274833_3 - 0.0026 16.9 3.1 0.006 15.7 3.1 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain DUF3809 PF12723.5 T182958_3 - 0.027 14.6 0.2 4.2e+02 1.0 0.0 5.7 3 3 3 8 8 8 0 Protein of unknown function (DUF3809) TLV_coat PF00429.17 T238781_3 - 1.1e-08 34.1 2.1 4.9e-08 32.0 2.1 1.9 1 1 0 1 1 1 1 ENV polyprotein (coat polyprotein) DUF1725 PF08333.9 T222970_1 - 1.3e-08 34.1 0.4 2.7e-08 33.1 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T222970_2 - 1.1e-31 110.0 0.6 1.7e-31 109.4 0.6 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BDV_P40 PF06407.9 T358160_1 - 1.7e-28 99.6 0.0 3e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 Borna disease virus P40 protein BDV_P40 PF06407.9 T358160_3 - 2.9e-14 52.8 0.1 4.5e-14 52.2 0.1 1.1 1 0 0 1 1 1 1 Borna disease virus P40 protein Transposase_1 PF01359.16 T346923_1 - 5.4e-14 51.7 0.1 1.3e-13 50.4 0.1 1.7 1 0 0 1 1 1 1 Transposase (partial DDE domain) HTH_5 PF01022.18 T346923_1 - 0.037 13.8 0.0 0.083 12.6 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.5 T346923_1 - 0.18 11.6 0.0 0.44 10.3 0.0 1.6 1 0 0 1 1 1 0 MarR family Transposase_1 PF01359.16 T346923_3 - 4.3e-08 32.8 3.6 8.8e-08 31.8 3.6 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) Peptidase_S49_N PF08496.8 T188409_2 - 3.5 7.6 5.6 6.9 6.6 5.6 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Transposase_1 PF01359.16 T312695_2 - 5.5e-29 99.7 0.0 1.1e-28 98.8 0.0 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) RVT_1 PF00078.25 T012478_1 - 1.1e-06 28.3 0.1 1.7e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T012478_2 - 2.2e-06 27.0 0.2 4.2e-06 26.1 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T012478_3 - 1.5e-06 27.7 1.0 6.1e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RhoGAP PF00620.25 T270478_2 - 3.3e-06 26.8 0.4 1e-05 25.3 0.2 1.9 2 0 0 2 2 2 1 RhoGAP domain DMP1 PF07263.9 T229978_1 - 6.1 5.5 8.2 12 4.5 8.2 1.4 1 1 0 1 1 1 0 Dentin matrix protein 1 (DMP1) Glutenin_hmw PF03157.11 T229978_3 - 0.2 9.9 23.8 0.25 9.6 23.8 1.1 1 0 0 1 1 1 0 High molecular weight glutenin subunit Transposase_22 PF02994.12 T103726_2 - 2.1e-142 474.2 20.5 2.8e-142 473.8 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103726_2 - 0.029 14.5 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103726_2 - 0.058 13.0 10.5 0.11 12.2 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103726_2 - 0.059 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103726_2 - 0.34 11.4 5.0 0.68 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103726_2 - 0.41 9.8 12.3 0.73 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103726_2 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103726_2 - 2.7 8.1 7.4 4.8 7.3 6.6 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein CCDC144C PF14915.4 T018737_1 - 4.9e-61 206.4 57.3 5.2e-36 124.2 14.1 3.3 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018737_1 - 5.2e-09 36.3 0.1 5.2e-09 36.3 0.1 4.3 4 0 0 4 4 4 1 Domain of unknown function (DUF3496) Laminin_II PF06009.10 T018737_1 - 0.0087 15.9 1.1 0.0087 15.9 1.1 2.9 3 0 0 3 3 3 1 Laminin Domain II CCDC144C PF14915.4 T018737_2 - 8.3e-17 61.1 9.6 8.3e-17 61.1 9.6 1.5 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region Transposase_22 PF02994.12 T283554_1 - 6.9e-55 186.3 0.6 9.9e-55 185.7 0.6 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T283554_1 - 8.5e-09 35.1 0.0 1.6e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T283554_1 - 0.00028 21.0 0.0 0.00061 19.9 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.25 T283554_2 - 2.8e-08 33.4 0.1 5.2e-08 32.6 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T283554_3 - 4e-38 131.1 11.4 4.6e-38 130.9 6.5 2.3 2 0 0 2 2 2 1 L1 transposable element DUF1725 PF08333.9 T283554_3 - 7.4e-06 25.3 0.2 1.5e-05 24.3 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T283554_3 - 8.3e-06 25.3 0.3 1.6e-05 24.4 0.3 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ASFV_J13L PF05568.9 T366583_2 - 3.8 7.1 4.5 6.5 6.3 4.5 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Transposase_1 PF01359.16 T083419_1 - 5.9e-21 74.0 0.1 9.9e-21 73.3 0.1 1.4 1 0 0 1 1 1 1 Transposase (partial DDE domain) IF2_N PF04760.13 T083419_2 - 0.039 13.6 0.1 0.075 12.7 0.1 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region MIP-T3 PF10243.7 T227248_3 - 0.00059 18.6 1.3 0.00091 17.9 1.3 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 DUF1725 PF08333.9 T253737_3 - 1e-07 31.3 0.1 1.9e-07 30.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Hexapep PF00132.22 T336912_2 - 0.026 14.1 0.0 29 4.5 0.0 3.8 3 1 1 4 4 4 0 Bacterial transferase hexapeptide (six repeats) Pentapeptide_2 PF01469.16 T051561_3 - 0.0078 15.9 6.1 0.17 11.7 3.5 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) zf-H2C2 PF09337.8 T268136_1 - 3e-07 30.5 0.2 6.9e-07 29.3 0.2 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RVT_1 PF00078.25 T268136_2 - 6.7e-12 45.3 0.0 1.1e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T268136_2 - 6.8e-11 42.4 0.0 1.5e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 RNase H TLV_coat PF00429.17 T066053_1 - 3.1e-51 174.6 3.6 4.9e-51 173.9 3.6 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) rve PF00665.24 T066053_1 - 7.5e-25 87.3 0.0 1.4e-24 86.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T066053_1 - 3.5e-22 79.0 0.0 5.2e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T066053_1 - 0.0028 17.1 0.0 0.0045 16.4 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein rve_3 PF13683.4 T066053_1 - 0.015 14.9 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain TLV_coat PF00429.17 T066053_2 - 2.8e-05 22.9 0.3 4.3e-05 22.3 0.3 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RVP PF00077.18 T066053_3 - 0.057 13.6 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease Herpes_BLLF1 PF05109.11 T172829_2 - 0.0017 16.3 10.7 0.0074 14.2 1.7 2.0 1 1 1 2 2 2 2 Herpes virus major outer envelope glycoprotein (BLLF1) IncA PF04156.12 T172829_2 - 0.19 11.3 0.0 4.7 6.8 0.0 2.2 1 1 1 2 2 2 0 IncA protein RVT_1 PF00078.25 T091124_2 - 1.5e-07 31.1 0.0 2.4e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PHO4 PF01384.18 T062625_3 - 0.0012 17.9 0.2 0.0012 17.9 0.2 1.1 1 0 0 1 1 1 1 Phosphate transporter family DUF4705 PF15788.3 T323260_1 - 0.0072 16.4 35.3 0.025 14.7 15.5 5.7 4 1 1 5 5 5 2 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323260_3 - 3.6e-05 23.8 22.5 0.00032 20.7 6.3 6.6 5 2 2 7 7 7 2 Domain of unknown function (DUF4705) Thymidylat_synt PF00303.17 T099953_1 - 0.6 9.1 11.0 1.9 7.4 1.4 3.3 1 1 2 3 3 3 0 Thymidylate synthase DUF1720 PF08226.9 T099953_2 - 0.0057 16.9 11.3 0.5 10.7 1.1 2.8 1 1 1 2 2 2 2 Domain of unknown function (DUF1720) KIAA1430 PF13879.4 T099992_1 - 4.6e-14 52.9 2.4 9.4e-14 51.9 2.4 1.5 1 0 0 1 1 1 1 KIAA1430 homologue Arylesterase PF01731.18 T381529_2 - 0.052 13.6 0.0 0.098 12.7 0.0 1.4 1 0 0 1 1 1 0 Arylesterase RNase_H PF00075.22 T065985_1 - 3.8e-17 62.7 0.0 6.6e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 RNase H rve PF00665.24 T065985_1 - 1.5e-05 25.1 0.0 2.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T065985_1 - 0.024 14.0 0.1 0.07 12.5 0.1 1.7 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T065985_2 - 0.00026 20.4 0.0 0.00042 19.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p30 PF02093.14 T065985_3 - 5.9e-16 58.5 0.0 9.1e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T065985_3 - 0.087 13.0 0.0 0.83 9.8 0.0 2.2 2 0 0 2 2 2 0 Retroviral aspartyl protease Colipase-like PF15083.4 T090317_1 - 3.5e-10 39.7 4.2 3.5e-10 39.7 4.2 2.0 2 0 0 2 2 2 1 Colipase-like Colipase-like PF15083.4 T090317_2 - 2.2e-31 107.7 13.5 3.8e-31 106.9 13.5 1.4 1 0 0 1 1 1 1 Colipase-like RVT_1 PF00078.25 T239483_2 - 3.9e-52 176.8 1.8 8.6e-52 175.7 1.8 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.4 T239483_2 - 0.0024 17.3 0.3 0.0057 16.1 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4417) YlbE PF14003.4 T239483_2 - 0.11 12.8 8.4 0.35 11.2 0.0 3.4 3 0 0 3 3 3 0 YlbE-like protein zf-ribbon_3 PF13248.4 T062563_2 - 5.7e-14 50.8 114.6 0.037 13.3 0.7 15.3 7 4 10 18 18 18 17 zinc-ribbon domain zf-ribbon_3 PF13248.4 T062563_3 - 1.5e-05 24.1 81.7 0.037 13.3 0.7 10.9 5 2 9 14 14 14 12 zinc-ribbon domain UPAR_LY6 PF00021.19 T353221_2 - 9.9e-06 26.0 6.1 9.9e-06 26.0 6.1 1.8 2 0 0 2 2 2 1 u-PAR/Ly-6 domain RVT_1 PF00078.25 T082035_1 - 6.8e-08 32.2 1.2 4e-07 29.6 1.2 2.1 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T082035_2 - 0.042 13.4 2.8 0.13 11.9 2.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Phosphodiest PF01663.20 T318338_2 - 0.00017 21.2 0.0 0.00022 20.8 0.0 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase FTHFS PF01268.17 T359285_3 - 7e-29 100.3 0.0 9.6e-29 99.9 0.0 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase DUF1725 PF08333.9 T182469_2 - 0.047 13.2 0.5 0.083 12.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T227004_1 - 6.4e-25 87.6 4.6 4.5e-20 71.7 2.3 2.1 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T227004_1 - 2.9e-06 26.8 0.3 2.9e-06 26.8 0.3 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T227004_2 - 1e-14 54.5 0.2 1.8e-14 53.7 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) UQ_con PF00179.24 T183434_1 - 6.3e-09 35.5 0.0 1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Transposase_22 PF02994.12 T103735_3 - 2.1e-142 474.2 20.5 2.9e-142 473.7 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103735_3 - 0.03 14.4 0.0 0.057 13.6 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103735_3 - 0.06 13.0 10.5 0.11 12.1 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103735_3 - 0.061 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103735_3 - 0.35 11.3 5.0 0.69 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103735_3 - 0.43 9.8 12.3 0.74 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103735_3 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103735_3 - 3 8.0 7.5 5.3 7.2 6.7 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Pentapeptide_4 PF13599.4 T018642_1 - 1.2e-29 102.2 0.0 4.8 7.2 0.0 23.9 26 3 0 26 26 26 8 Pentapeptide repeats (9 copies) Lamprin PF06403.9 T018642_1 - 0.75 9.6 12.8 53 3.6 0.0 8.5 10 0 0 10 10 10 0 Lamprin Pentapeptide_4 PF13599.4 T018642_2 - 7.5e-34 115.6 0.0 0.29 11.2 0.0 26.4 28 5 2 30 30 30 8 Pentapeptide repeats (9 copies) Lamprin PF06403.9 T018642_2 - 5.3e-05 23.1 6.6 63 3.4 0.0 9.0 9 0 0 9 9 9 2 Lamprin Pentapeptide_4 PF13599.4 T018642_3 - 6.6e-42 141.4 0.0 0.063 13.3 0.0 25.7 26 5 1 28 28 28 12 Pentapeptide repeats (9 copies) Lamprin PF06403.9 T018642_3 - 0.16 11.8 16.8 14 5.5 0.0 9.9 16 0 0 16 16 16 0 Lamprin Peptidase_M24_C PF16188.3 T227651_2 - 0.17 11.9 1.6 2.3e+02 1.8 0.0 5.2 2 2 2 5 5 5 0 C-terminal region of peptidase_M24 Med28 PF11594.6 T227651_3 - 0.0065 16.4 14.2 23 4.9 0.1 7.9 3 2 6 9 9 9 2 Mediator complex subunit 28 cEGF PF12662.5 T278131_3 - 0.84 9.5 4.6 0.39 10.6 0.7 2.6 2 0 0 2 2 2 0 Complement Clr-like EGF-like DUF478 PF04334.10 T354537_3 - 0.037 13.9 0.0 0.09 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF478) Lbh PF15317.4 T110893_3 - 9.8e-09 35.9 0.3 1.7e-08 35.1 0.3 1.3 1 0 0 1 1 1 1 Cardiac transcription factor regulator, Developmental protein Transposase_22 PF02994.12 T103716_2 - 2.1e-142 474.2 20.5 2.9e-142 473.8 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103716_2 - 0.03 14.5 0.0 0.056 13.6 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103716_2 - 0.059 13.0 10.5 0.11 12.2 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103716_2 - 0.06 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103716_2 - 0.34 11.4 5.0 0.69 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103716_2 - 0.42 9.8 12.3 0.74 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103716_2 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103716_2 - 3 8.0 7.5 5.3 7.2 6.7 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Toxin_26 PF08097.9 T259869_1 - 0.4 11.3 6.3 1.1 10.0 6.3 1.8 1 0 0 1 1 1 0 Conotoxin T-superfamily RNase_H PF00075.22 T338008_1 - 1.6e-07 31.4 0.0 3e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T338008_1 - 1.5e-06 27.8 0.0 2.7e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.8 T338008_1 - 5.1e-06 26.5 1.2 1.1e-05 25.5 1.2 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve PF00665.24 T338008_3 - 2.4e-16 59.9 0.0 3.7e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.4 T338008_3 - 0.017 14.7 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain RVP PF00077.18 T307841_1 - 8.6e-14 51.5 0.0 1.7e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RNase_H PF00075.22 T307841_1 - 2e-13 50.6 0.0 4.2e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T307841_1 - 5.7e-11 42.2 0.2 8.7e-11 41.6 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T307841_1 - 0.013 15.4 3.0 0.03 14.3 3.0 1.7 1 0 0 1 1 1 0 Zinc knuckle Asp_protease_2 PF13650.4 T307841_1 - 0.019 15.5 0.0 0.032 14.8 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T307841_1 - 0.022 15.2 0.0 0.036 14.5 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-C2H2_10 PF16588.3 T307841_1 - 0.04 13.5 0.8 0.095 12.3 0.8 1.6 1 0 0 1 1 1 0 C2H2 zinc-finger RVT_1 PF00078.25 T307841_2 - 5.6e-11 42.3 0.0 7.7e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T307841_3 - 1.1e-19 70.7 0.0 1.8e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T307841_3 - 1.9e-09 37.2 0.0 3.1e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Toxin_18 PF08087.9 T020148_2 - 0.044 13.6 4.4 0.71 9.8 0.1 2.9 2 0 0 2 2 2 0 Conotoxin O-superfamily Colipase-like PF15083.4 T090349_3 - 3.5e-47 158.3 26.0 2.2e-38 130.1 13.7 2.4 1 1 1 2 2 2 2 Colipase-like Mucin-like PF16058.3 T300742_1 - 0.013 15.4 5.6 0.034 14.1 5.6 1.8 1 0 0 1 1 1 0 Mucin-like Herpes_LMP1 PF05297.9 T300742_1 - 5.1 6.1 8.0 7.9 5.4 8.0 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Epiglycanin_C PF14654.4 T300742_2 - 3.8e-09 36.4 0.7 7.3e-09 35.5 0.7 1.4 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300742_2 - 2.2e-06 27.6 4.4 5e-06 26.4 4.4 1.5 1 0 0 1 1 1 1 Mucin-like Toxin_18 PF08087.9 T279378_3 - 0.53 10.2 5.7 0.57 10.1 0.2 2.7 2 0 0 2 2 2 0 Conotoxin O-superfamily Transposase_1 PF01359.16 T330238_1 - 0.0014 18.3 1.9 0.0038 16.9 1.9 1.7 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T330238_3 - 1.3e-18 66.5 0.0 4.1e-18 64.9 0.0 1.9 1 0 0 1 1 1 1 Transposase (partial DDE domain) PLA2_inh PF02988.13 T035082_1 - 0.075 13.6 4.3 0.17 12.4 4.3 1.6 1 0 0 1 1 1 0 Phospholipase A2 inhibitor UPAR_LY6 PF00021.19 T035082_1 - 0.25 11.9 6.2 0.33 11.5 5.3 1.7 2 0 0 2 2 2 0 u-PAR/Ly-6 domain RVT_1 PF00078.25 T261686_2 - 1.6e-37 129.0 3.2 2.2e-37 128.6 3.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T097872_1 - 7.1e-13 48.4 0.1 1.3e-12 47.6 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.4 T097872_1 - 0.00014 21.6 0.7 0.00026 20.7 0.7 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Transposase_22 PF02994.12 T097872_2 - 9.9e-57 192.3 27.9 1.2e-51 175.6 22.9 2.9 2 1 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T097872_2 - 2.6e-06 26.8 1.1 6e-06 25.6 1.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos PF03372.21 T097872_2 - 0.038 14.1 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family HSBP1 PF06825.10 T097872_2 - 0.17 11.7 4.5 4.9 7.0 0.5 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Syntaxin-6_N PF09177.9 T097872_2 - 0.27 11.7 5.0 0.79 10.2 5.0 1.8 1 0 0 1 1 1 0 Syntaxin 6, N-terminal IncA PF04156.12 T097872_2 - 5.6 6.6 12.0 1.7 8.3 5.4 2.4 2 0 0 2 2 2 0 IncA protein Transposase_22 PF02994.12 T097872_3 - 7.4e-25 87.4 0.0 1.2e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T097872_3 - 2e-15 56.8 0.5 3.1e-15 56.2 0.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF982 PF06169.10 T079597_3 - 5.5 7.0 6.0 12 5.9 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF982) V-set PF07686.15 T248996_3 - 2.4e-07 30.8 0.7 1.3e-06 28.4 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.14 T248996_3 - 0.005 16.7 0.1 0.1 12.5 0.0 2.9 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 T248996_3 - 0.016 15.3 0.9 0.17 12.0 0.1 2.6 2 1 0 2 2 2 0 Immunoglobulin domain TLV_coat PF00429.17 T274370_1 - 0.00092 17.9 5.3 0.0092 14.6 1.9 2.3 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) RVT_1 PF00078.25 T370872_1 - 0.042 13.2 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T370872_3 - 6.2e-22 78.2 0.0 1.1e-21 77.4 0.0 1.3 1 0 0 1 1 1 1 RNase H rve PF00665.24 T370872_3 - 1.4e-10 41.3 0.0 2.3e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T370872_3 - 1.3e-06 28.4 0.1 3.4e-06 27.1 0.1 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger CHB_HEX_C_1 PF13290.4 T370223_2 - 0.096 12.6 0.2 24 4.9 0.0 3.4 3 0 0 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain DUF4705 PF15788.3 T324544_1 - 3.4e-36 123.1 406.5 8.5e-16 57.8 9.2 34.8 19 10 10 29 29 29 19 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324544_2 - 3.6e-53 177.4 372.4 7.8e-17 61.1 7.3 36.1 18 11 14 33 33 33 24 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324544_3 - 8.9e-76 249.8 350.6 3.9e-08 33.2 7.8 35.8 21 8 11 32 32 32 28 Domain of unknown function (DUF4705) DUF4417 PF14386.4 T325338_1 - 0.076 12.5 0.1 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) DUF4801 PF16059.3 T179758_3 - 0.047 13.6 0.2 0.12 12.3 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4801) DUF3678 PF12435.6 T179758_3 - 0.052 12.7 0.5 0.23 10.6 0.5 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) DUF912 PF06024.10 T089752_2 - 0.11 12.6 1.9 12 6.2 0.3 3.7 4 0 0 4 4 4 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4834 PF16118.3 T089752_3 - 0.68 10.8 16.8 1.1 10.1 0.1 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4834) PDGF PF00341.15 T348534_3 - 4.2 7.6 10.8 0.98 9.6 0.4 2.7 3 0 0 3 3 3 0 PDGF/VEGF domain SSP160 PF06933.9 T111410_3 - 1 7.4 22.9 1.5 6.8 22.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Ldl_recept_a PF00057.16 T284219_2 - 5.1e-08 32.9 12.4 3.8e-05 23.7 1.6 2.7 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.5 T284219_2 - 0.18 11.5 5.1 0.26 11.0 5.1 1.2 1 0 0 1 1 1 0 Glucosidase II beta subunit-like RVT_1 PF00078.25 T246151_1 - 0.0013 18.2 0.0 0.0023 17.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4705 PF15788.3 T323217_1 - 4.6e-36 122.7 262.1 8.6e-09 35.3 6.9 22.2 13 9 7 20 20 20 11 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323217_2 - 5.6e-58 192.8 257.6 1.9e-17 63.0 8.0 24.8 14 9 9 23 23 23 16 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323217_3 - 2.3e-23 82.0 249.0 9.3e-12 44.8 11.0 24.2 16 7 5 22 22 22 14 Domain of unknown function (DUF4705) Gag_p30 PF02093.14 T370869_1 - 5.4e-29 101.1 0.0 8.8e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RNase_H PF00075.22 T370869_1 - 2.9e-07 30.7 0.0 5.3e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p24 PF00607.18 T370869_1 - 0.018 14.8 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 gag gene protein p24 (core nucleocapsid protein) RVT_1 PF00078.25 T370869_2 - 6.8e-22 77.9 0.0 9.4e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T370869_2 - 1.3e-15 57.4 0.1 2.2e-15 56.6 0.1 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T370869_2 - 3.9e-13 49.4 0.0 7.9e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.4 T370869_2 - 0.00043 20.8 0.0 0.00091 19.7 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.4 T370869_2 - 0.002 18.5 0.0 0.0039 17.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.21 T370869_2 - 0.0079 16.1 2.6 0.028 14.4 2.6 2.1 1 0 0 1 1 1 1 Zinc knuckle zf-C2H2_10 PF16588.3 T370869_2 - 0.076 12.6 0.5 0.23 11.1 0.5 1.9 1 0 0 1 1 1 0 C2H2 zinc-finger Transposase_22 PF02994.12 T378564_1 - 2e-64 217.6 21.4 3.6e-37 128.0 5.0 3.2 3 0 0 3 3 3 3 L1 transposable element RVT_1 PF00078.25 T378564_1 - 2e-10 40.5 0.0 3.6e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T378564_2 - 2.3e-15 56.6 0.2 3.4e-15 56.0 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T378564_3 - 3.9e-22 78.5 0.1 9.3e-22 77.2 0.1 1.6 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T378564_3 - 3.9e-10 39.5 0.4 8.9e-10 38.3 0.4 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.4 T378564_3 - 6.3e-06 25.9 0.9 1.3e-05 24.9 0.9 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T378564_3 - 0.016 15.3 0.0 0.037 14.2 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF1725 PF08333.9 T378564_3 - 0.087 12.4 0.7 0.19 11.3 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) DUF1510 PF07423.9 T275906_1 - 0.012 14.9 0.0 0.012 14.9 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1510) LRRC37AB_C PF14914.4 T275906_1 - 0.012 15.4 0.2 0.035 13.9 0.2 1.7 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF3446 PF11928.6 T275906_1 - 0.018 15.2 6.0 0.11 12.7 6.0 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) DUF912 PF06024.10 T275906_1 - 0.053 13.7 0.3 0.053 13.7 0.3 2.7 2 2 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ODV-E18 PF10717.7 T275906_1 - 0.06 13.1 4.9 0.11 12.2 4.9 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 EphA2_TM PF14575.4 T275906_1 - 0.061 14.0 0.2 0.061 14.0 0.2 7.8 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.4 T275906_1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family ASFV_J13L PF05568.9 T275906_1 - 8.5 6.0 6.8 16 5.1 6.8 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF3446 PF11928.6 T275906_2 - 0.037 14.2 11.6 0.071 13.3 11.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) SR-25 PF10500.7 T275906_2 - 1.4 8.4 12.4 2 7.9 12.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SelP_N PF04592.12 T275906_2 - 3.1 7.0 17.9 4.5 6.5 17.9 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF912 PF06024.10 T275906_3 - 1.6 8.9 0.0 1.6 8.9 0.0 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) RVT_1 PF00078.25 T343480_1 - 1.1e-35 123.0 0.6 1.8e-35 122.3 0.6 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T343480_1 - 8e-07 29.2 0.0 1.4e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T343480_2 - 8.6e-137 455.7 20.8 1.2e-136 455.3 20.8 1.2 1 0 0 1 1 1 1 L1 transposable element ATG16 PF08614.9 T343480_2 - 0.015 15.3 10.2 0.028 14.5 10.2 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) IncA PF04156.12 T343480_2 - 0.022 14.4 9.8 0.043 13.5 9.8 1.4 1 0 0 1 1 1 0 IncA protein Syntaxin-6_N PF09177.9 T343480_2 - 0.28 11.6 5.3 0.59 10.6 5.3 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal KLRAQ PF10205.7 T343480_2 - 0.49 10.5 9.7 2.4 8.3 9.7 2.2 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Occludin_ELL PF07303.11 T343480_2 - 1 9.9 7.2 3.2 8.4 7.2 1.8 1 0 0 1 1 1 0 Occludin homology domain Spectrin PF00435.19 T343480_2 - 1.2 9.5 5.6 2.7 8.4 5.6 1.5 1 0 0 1 1 1 0 Spectrin repeat Seryl_tRNA_N PF02403.20 T343480_2 - 1.8 8.7 7.7 3.9 7.6 7.7 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain RVT_1 PF00078.25 T343480_3 - 0.013 14.9 0.1 0.018 14.4 0.1 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T004819_1 - 5.2e-19 68.7 0.0 9.9e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T004819_1 - 8.6e-15 54.7 0.0 1.4e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T004819_1 - 8.8e-11 41.8 0.0 1.8e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T004819_1 - 2.1e-10 40.7 0.0 3.6e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T004819_2 - 3.4e-21 75.6 0.0 4.8e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T004819_3 - 9.2e-19 67.7 1.7 4.8e-16 58.8 0.8 2.1 2 0 0 2 2 2 2 Gag P30 core shell protein Gag_MA PF01140.17 T004819_3 - 7.9e-13 48.1 0.2 1.9e-12 46.8 0.0 1.7 2 0 0 2 2 2 1 Matrix protein (MA), p15 DUF1725 PF08333.9 T250066_2 - 2.4e-06 26.9 0.3 5.2e-06 25.8 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) CCDC144C PF14915.4 T018782_1 - 2.1e-59 201.0 37.8 1.7e-35 122.5 14.1 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region BAR_3_WASP_bdg PF10456.7 T018782_1 - 2.3e-12 46.8 0.1 2.3e-12 46.8 0.1 2.7 3 0 0 3 3 3 1 WASP-binding domain of Sorting nexin protein DUF3496 PF12001.6 T018782_1 - 5.6e-07 29.8 9.0 5.6e-07 29.8 9.0 3.9 3 1 1 4 4 4 1 Domain of unknown function (DUF3496) Laminin_II PF06009.10 T018782_1 - 1.8 8.5 13.2 0.029 14.3 1.1 2.5 2 0 0 2 2 2 0 Laminin Domain II CCDC144C PF14915.4 T018782_2 - 1.5e-16 60.3 9.6 2.7e-16 59.4 9.6 1.3 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region BAR_3_WASP_bdg PF10456.7 T018782_2 - 3.4e-16 59.3 0.9 2e-08 33.9 0.3 2.3 2 0 0 2 2 2 2 WASP-binding domain of Sorting nexin protein zf-AN1 PF01428.14 T235997_3 - 2.8 8.1 7.7 0.35 10.9 0.5 3.3 2 0 0 2 2 2 0 AN1-like Zinc finger PHO4 PF01384.18 T138164_3 - 0.0013 17.7 0.0 0.0013 17.7 0.0 1.1 1 0 0 1 1 1 1 Phosphate transporter family RVT_1 PF00078.25 T376716_2 - 1.5e-13 50.7 0.0 3e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T376716_3 - 2e-17 63.3 1.1 3.4e-17 62.6 1.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T376716_3 - 2.9e-08 33.0 0.1 5.6e-08 32.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1725 PF08333.9 T083139_1 - 0.0012 18.3 0.2 0.0012 18.3 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T083139_2 - 3.8e-06 26.5 0.0 8.2e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T083139_2 - 0.022 14.8 0.0 0.048 13.8 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T083139_3 - 0.00039 20.1 0.7 0.00084 19.1 0.7 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase LEA_1 PF03760.13 T106795_3 - 0.084 13.4 3.6 0.19 12.3 0.1 2.3 2 0 0 2 2 2 0 Late embryogenesis abundant (LEA) group 1 TT_ORF2 PF02957.13 T353475_2 - 0.065 14.0 0.1 0.065 14.0 0.1 2.4 2 0 0 2 2 2 0 TT viral ORF2 HERV-K_env_2 PF13804.4 T080890_1 - 2e-120 398.5 2.9 3.4e-120 397.8 2.9 1.4 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_REC PF15695.3 T080890_1 - 1.5e-52 175.4 9.7 2.8e-52 174.6 9.7 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 GP41 PF00517.15 T080890_1 - 5.1e-25 88.4 5.1 5.8e-25 88.2 3.9 1.7 2 0 0 2 2 2 1 Retroviral envelope protein Toxin_18 PF08087.9 T080890_3 - 0.033 14.1 10.4 0.092 12.6 10.4 1.8 1 0 0 1 1 1 0 Conotoxin O-superfamily MRP-L28 PF09812.7 T369083_2 - 1.7 8.6 5.5 3.5 7.6 5.5 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 MdoG PF04349.10 T125884_3 - 0.039 12.7 0.4 0.055 12.3 0.4 1.1 1 0 0 1 1 1 0 Periplasmic glucan biosynthesis protein, MdoG DUF4705 PF15788.3 T324667_1 - 1.7e-15 56.8 165.0 0.0036 17.3 15.9 14.5 11 3 1 12 12 12 9 Domain of unknown function (DUF4705) Ribosomal_S3_C PF00189.18 T324667_1 - 0.068 13.6 0.3 15 6.1 0.1 2.7 2 0 0 2 2 2 0 Ribosomal protein S3, C-terminal domain DUF4705 PF15788.3 T324667_2 - 0.0014 18.6 10.5 0.0014 18.6 10.5 15.8 10 4 3 14 14 14 8 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324667_3 - 6.9e-33 112.5 175.3 4.9e-05 23.3 9.3 15.0 10 4 4 14 14 14 10 Domain of unknown function (DUF4705) PTP_N PF12453.6 T324667_3 - 2.6 7.7 6.2 2e+02 1.7 0.1 4.2 4 0 0 4 4 4 0 Protein tyrosine phosphatase N terminal RVT_1 PF00078.25 T069162_1 - 2.2e-11 43.6 0.1 3.7e-11 42.8 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T069162_2 - 3.2e-21 75.6 0.0 5.9e-21 74.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T069162_2 - 1.1e-20 74.2 0.0 1.6e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 RNase H TLV_coat PF00429.17 T069162_2 - 4e-16 58.7 3.4 6.1e-16 58.1 3.4 1.3 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RVP PF00077.18 T069162_2 - 0.0005 20.2 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_3 PF13456.4 T069162_2 - 0.12 12.0 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like TLV_coat PF00429.17 T069162_3 - 3.5e-21 75.4 9.0 4.3e-16 58.6 3.0 2.2 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) GFO_IDH_MocA_C PF02894.15 T001690_1 - 0.1 12.5 0.0 0.28 11.0 0.0 1.6 2 0 0 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain Serpin PF00079.18 T295987_1 - 1.7e-05 24.2 0.0 2.5e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3809 PF12723.5 T182962_3 - 0.027 14.6 0.2 3.2e+02 1.4 0.0 5.7 3 3 5 8 8 8 0 Protein of unknown function (DUF3809) Transposase_22 PF02994.12 T266277_2 - 3.7e-95 318.8 20.5 2.5e-92 309.5 10.8 2.3 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T266277_2 - 4.6e-06 26.0 2.1 9.1e-06 25.1 2.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) HSBP1 PF06825.10 T266277_2 - 0.25 11.2 1.8 0.64 9.9 0.3 2.3 2 0 0 2 2 2 0 Heat shock factor binding protein 1 RVT_1 PF00078.25 T266277_3 - 6.2e-20 71.5 0.2 1e-19 70.8 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T172336_2 - 2.5e-05 24.4 0.0 4.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 RNase H Colipase-like PF15083.4 T090320_1 - 5.2e-11 42.4 1.6 5.2e-11 42.4 1.6 1.8 2 0 0 2 2 2 1 Colipase-like Colipase-like PF15083.4 T090320_3 - 1.2e-32 111.8 10.9 2.1e-32 111.0 10.9 1.4 1 0 0 1 1 1 1 Colipase-like Colipase PF01114.16 T090320_3 - 8.8 6.0 10.9 3.8 7.1 1.8 2.5 2 0 0 2 2 2 0 Colipase, N-terminal domain Plasmodium_Vir PF05795.9 T305700_1 - 0.035 13.4 7.9 0.052 12.8 7.9 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Toxin_18 PF08087.9 T020141_2 - 0.026 14.4 4.4 0.57 10.1 0.1 3.0 2 0 0 2 2 2 0 Conotoxin O-superfamily Transposase_22 PF02994.12 T015055_1 - 7.9e-145 482.2 22.3 5e-114 380.8 17.7 2.2 2 0 0 2 2 2 2 L1 transposable element Seryl_tRNA_N PF02403.20 T015055_1 - 0.0067 16.5 7.9 0.014 15.4 7.9 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Sec34 PF04136.13 T015055_1 - 0.035 13.8 2.3 0.058 13.1 2.3 1.3 1 0 0 1 1 1 0 Sec34-like family Syntaxin-6_N PF09177.9 T015055_1 - 0.037 14.5 8.6 0.028 14.8 6.3 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Spectrin PF00435.19 T015055_1 - 0.042 14.2 4.5 0.096 13.1 4.5 1.6 1 0 0 1 1 1 0 Spectrin repeat ArAE_2_N PF10337.7 T015055_1 - 0.051 12.5 0.2 0.075 11.9 0.2 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal DUF4613 PF15390.4 T015055_1 - 0.14 10.3 3.7 0.2 9.8 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF1664 PF07889.10 T015055_1 - 0.18 11.6 1.4 0.33 10.8 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Prominin PF05478.9 T015055_1 - 0.57 7.9 4.1 0.81 7.4 4.1 1.1 1 0 0 1 1 1 0 Prominin DUF16 PF01519.14 T015055_1 - 1.4 9.3 7.5 33 4.9 7.5 2.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 TMPIT PF07851.11 T015055_1 - 3.8 6.5 5.5 6.6 5.7 5.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein IncA PF04156.12 T015055_1 - 4.6 6.9 18.9 0.31 10.7 13.9 1.5 2 0 0 2 2 2 0 IncA protein TSC22 PF01166.16 T015055_1 - 6.1 7.1 6.7 2 8.6 1.5 2.7 2 1 1 3 3 3 0 TSC-22/dip/bun family Exo_endo_phos PF03372.21 T015055_2 - 5e-09 36.3 0.0 8.8e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T015055_2 - 9.2e-09 35.0 1.6 1.9e-08 34.0 1.6 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Baculo_PEP_C PF04513.10 T015055_2 - 3.6 7.5 5.5 11 6.0 1.7 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RVT_thumb PF06817.12 T230561_1 - 8.9e-08 31.6 0.4 1.7e-07 30.7 0.4 1.4 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVT_1 PF00078.25 T230561_1 - 2.2e-05 23.9 0.0 3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Borrelia_orfX PF04160.10 T230561_1 - 0.015 15.2 0.4 0.027 14.3 0.4 1.3 1 0 0 1 1 1 0 Orf-X protein RVP PF00077.18 T230561_1 - 0.14 12.4 0.1 1.4 9.1 0.1 2.1 1 1 1 2 2 2 0 Retroviral aspartyl protease Gag_p24 PF00607.18 T230561_2 - 1.1e-69 234.3 1.5 1.6e-69 233.8 0.3 1.8 2 0 0 2 2 2 1 gag gene protein p24 (core nucleocapsid protein) Gag_p10 PF02337.15 T230561_2 - 2.3e-27 94.5 0.2 4.5e-27 93.6 0.2 1.4 1 0 0 1 1 1 1 Retroviral GAG p10 protein RVT_thumb PF06817.12 T230561_2 - 9.4e-16 57.2 0.0 2.2e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain dUTPase PF00692.17 T230561_2 - 4.2e-10 39.3 0.0 8e-10 38.4 0.0 1.5 1 0 0 1 1 1 1 dUTPase IN_DBD_C PF00552.19 T230561_2 - 2.1e-06 26.8 1.2 4e-06 25.9 1.2 1.4 1 0 0 1 1 1 1 Integrase DNA binding domain zf-CCHC PF00098.21 T230561_2 - 3.2e-06 26.8 2.5 9.2e-06 25.4 2.5 1.9 1 0 0 1 1 1 1 Zinc knuckle RVT_1 PF00078.25 T230561_2 - 0.0013 18.2 0.1 0.0023 17.4 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_6 PF15288.4 T230561_2 - 0.068 12.9 2.2 0.087 12.6 0.4 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.4 T230561_2 - 0.13 11.8 1.1 0.28 10.8 1.1 1.5 1 0 0 1 1 1 0 Zinc knuckle rve PF00665.24 T230561_3 - 8.6e-25 87.1 0.0 2e-24 85.9 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain zf-CCHC_5 PF14787.4 T230561_3 - 7.7e-19 67.0 7.6 7.7e-19 67.0 7.6 2.6 3 0 0 3 3 3 1 GAG-polyprotein viral zinc-finger Integrase_Zn PF02022.17 T230561_3 - 9.2e-15 54.2 2.7 2.2e-14 53.0 2.7 1.7 1 0 0 1 1 1 1 Integrase Zinc binding domain RNase_H PF00075.22 T230561_3 - 3.2e-08 33.8 0.0 5.9e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T230561_3 - 0.028 13.8 0.1 0.061 12.7 0.1 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_IS240 PF13610.4 T230561_3 - 0.031 14.4 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 DDE domain zf-CCHC_3 PF13917.4 T230561_3 - 0.067 13.0 1.1 0.25 11.2 1.1 2.0 1 0 0 1 1 1 0 Zinc knuckle DUF1664 PF07889.10 T039038_3 - 0.0029 17.4 2.0 0.73 9.7 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) Laminin_II PF06009.10 T039038_3 - 0.14 12.0 0.0 3.7 7.4 0.0 2.3 1 1 1 2 2 2 0 Laminin Domain II APG6 PF04111.10 T039038_3 - 0.58 9.4 7.9 0.9 8.7 7.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.9 T039038_3 - 1 8.0 6.5 1.5 7.5 2.6 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein FliJ PF02050.14 T039038_3 - 2.1 8.4 27.9 3.9 7.6 10.0 2.5 1 1 1 2 2 2 0 Flagellar FliJ protein CENP-F_leu_zip PF10473.7 T039038_3 - 2.6 7.9 6.7 15 5.4 3.3 2.3 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Retrotrans_gag PF03732.15 T039038_3 - 2.6 8.2 10.5 33 4.7 0.3 3.8 1 1 3 4 4 4 0 Retrotransposon gag protein Serine_rich PF08824.8 T039038_3 - 3.4 7.5 18.1 9.5 6.1 4.6 2.5 1 1 1 2 2 2 0 Serine rich protein interaction domain Fib_alpha PF08702.8 T039038_3 - 3.8 7.5 4.7 2.5 8.1 1.0 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Snapin_Pallidin PF14712.4 T039038_3 - 6.2 7.2 18.5 4.8 7.6 4.0 2.4 2 0 0 2 2 2 0 Snapin/Pallidin EzrA PF06160.10 T039038_3 - 7.7 4.4 7.2 11 3.9 7.2 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA BAR_3_WASP_bdg PF10456.7 T018762_1 - 3.5e-13 49.4 0.4 1.6e-12 47.3 0.1 1.9 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein BAR_3_WASP_bdg PF10456.7 T018762_2 - 1.7e-16 60.3 0.9 1.4e-08 34.4 0.3 2.3 2 0 0 2 2 2 2 WASP-binding domain of Sorting nexin protein Ferritin PF00210.22 T246631_3 - 1.1e-05 25.3 1.2 2.8e-05 23.9 0.7 1.7 1 1 1 2 2 2 2 Ferritin-like domain HERV-K_env_2 PF13804.4 T237728_1 - 1.9e-94 314.0 0.7 3e-94 313.3 0.7 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GP41 PF00517.15 T237728_1 - 3.7e-10 39.8 0.1 5.9e-10 39.2 0.1 1.2 1 0 0 1 1 1 1 Retroviral envelope protein Gag_p24 PF00607.18 T237728_2 - 9e-74 247.6 0.2 1.3e-73 247.2 0.2 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) zf-CCHC_5 PF14787.4 T237728_2 - 4.9e-20 70.8 5.6 4.9e-20 70.8 5.6 2.8 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger dUTPase PF00692.17 T237728_2 - 1.7e-19 69.6 0.0 2.7e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 dUTPase zf-CCHC PF00098.21 T237728_2 - 5.3e-06 26.1 3.8 5.3e-06 26.1 3.8 2.8 2 0 0 2 2 2 1 Zinc knuckle RVP PF00077.18 T237728_2 - 7.5e-05 22.8 0.0 0.00035 20.7 0.0 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.4 T237728_2 - 1.3 9.0 5.5 9.7 6.1 0.3 2.6 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.24 T237728_3 - 1.4e-09 38.0 0.0 2.4e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.18 T237728_3 - 1.5e-07 31.5 0.0 2.9e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease IN_DBD_C PF00552.19 T237728_3 - 6.1e-06 25.3 1.7 1.3e-05 24.3 1.7 1.5 1 0 0 1 1 1 1 Integrase DNA binding domain HERV-K_env_2 PF13804.4 T237728_3 - 2.8e-05 23.8 1.0 4.4e-05 23.2 1.0 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Furin-like_2 PF15913.3 T362260_1 - 0.031 14.3 2.0 0.099 12.7 1.1 2.1 2 0 0 2 2 2 0 Furin-like repeat, cysteine-rich Fez1 PF06818.13 T330817_1 - 0.00054 20.3 7.7 0.87 9.9 4.4 3.6 1 1 1 2 2 2 2 Fez1 HrpB7 PF09486.8 T330817_1 - 0.0095 16.2 9.7 4.4 7.5 0.2 4.5 2 1 3 6 6 6 3 Bacterial type III secretion protein (HrpB7) ATG16 PF08614.9 T330817_1 - 0.11 12.5 6.1 0.85 9.6 0.4 2.5 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.9 T330817_1 - 0.46 10.8 29.9 0.54 10.6 1.4 6.4 3 2 3 6 6 6 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.10 T330817_1 - 4.3 7.2 12.2 0.38 10.6 1.8 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.9 T330817_2 - 0.36 11.1 23.8 0.69 10.2 0.7 5.1 2 2 3 5 5 5 0 Flagella accessory protein C (FlaC) DUF1325 PF07039.9 T129492_2 - 0.064 13.2 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 SGF29 tudor-like domain GATase_7 PF13537.4 T222956_3 - 2.1e-16 59.8 0.0 3.2e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.4 T222956_3 - 3.6e-12 46.5 0.0 5.2e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.6 T222956_3 - 0.1 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Aluminium induced protein SelP_N PF04592.12 T184390_2 - 1 8.6 12.3 1.7 7.8 12.3 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1725 PF08333.9 T268280_1 - 5.1e-05 22.7 1.8 0.00011 21.6 1.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Colipase-like PF15083.4 T090336_1 - 7e-43 144.5 21.7 2.1e-31 107.8 11.6 2.6 2 0 0 2 2 2 2 Colipase-like YdjO PF14169.4 T225041_1 - 0.089 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Cold-inducible protein YdjO Gag_p30 PF02093.14 T089136_2 - 2.1e-14 53.4 0.0 3e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein zf-CCHC PF00098.21 T089136_2 - 1.5e-05 24.7 1.0 1.5e-05 24.7 1.0 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T089136_2 - 0.033 13.8 2.7 0.084 12.5 2.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger 1-cysPrx_C PF10417.7 T258639_2 - 0.00015 21.4 1.0 17 5.2 0.1 6.2 6 0 0 6 6 6 3 C-terminal domain of 1-Cys peroxiredoxin DUF912 PF06024.10 T051334_2 - 0.00035 20.7 0.2 0.43 10.8 0.0 3.2 3 0 0 3 3 3 2 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1510 PF07423.9 T275913_1 - 0.0073 15.6 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) LRRC37AB_C PF14914.4 T275913_1 - 0.02 14.7 0.2 0.034 13.9 0.2 1.3 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF912 PF06024.10 T275913_1 - 0.022 14.9 0.0 0.042 14.0 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) EphA2_TM PF14575.4 T275913_1 - 0.08 13.6 0.2 0.08 13.6 0.2 3.0 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ODV-E18 PF10717.7 T275913_1 - 0.085 12.6 5.6 0.18 11.6 5.6 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 TMEM154 PF15102.4 T275913_1 - 0.14 12.0 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF1777 PF08648.10 T275913_1 - 0.33 11.1 16.4 0.47 10.5 16.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) ASFV_J13L PF05568.9 T275913_1 - 9.4 5.8 6.8 15 5.1 6.8 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF3446 PF11928.6 T275913_2 - 0.039 14.1 11.6 0.068 13.3 11.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) SR-25 PF10500.7 T275913_2 - 1.3 8.4 12.4 1.9 7.9 12.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SelP_N PF04592.12 T275913_2 - 2.8 7.1 17.9 4.3 6.5 17.9 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region EVI2A PF05399.9 T275913_3 - 0.035 13.6 1.7 0.057 12.9 1.7 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) SelP_N PF04592.12 T275913_3 - 2.1 7.6 22.9 3 7.0 22.9 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PRCC PF10253.7 T275913_3 - 6.9 7.3 13.9 9.4 6.8 13.9 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF1180 PF06679.10 T275913_3 - 9.5 6.5 10.5 15 5.8 10.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Transposase_1 PF01359.16 T352144_2 - 2.5e-25 88.0 0.3 5.8e-25 86.8 0.3 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) DUF3737 PF12541.6 T211922_3 - 1.5e-06 27.5 16.3 0.022 13.8 1.9 3.9 1 1 3 4 4 4 4 Protein of unknown function (DUF3737) SMBP PF16785.3 T211922_3 - 0.65 10.1 17.9 2.5 8.2 0.9 5.5 1 1 5 6 6 6 0 Small metal-binding protein Ank_5 PF13857.4 T353743_1 - 0.00016 21.8 0.0 0.003 17.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 T353743_1 - 0.00069 20.0 0.0 0.0015 18.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T353743_1 - 0.025 15.0 0.0 0.058 13.9 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.4 T353743_1 - 0.036 14.5 0.0 2.5 8.8 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeat Ank PF00023.28 T353743_1 - 0.087 13.2 0.1 15 6.1 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeat DUF3704 PF12488.6 T353743_2 - 1.1 8.9 5.1 3.4 7.3 5.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) TMEM191C PF15194.4 T230007_1 - 6e-21 74.7 0.3 1.2e-20 73.6 0.3 1.5 1 0 0 1 1 1 1 TMEM191C family ExsD PF16806.3 T230007_1 - 0.018 14.9 3.1 0.029 14.2 3.1 1.2 1 0 0 1 1 1 0 Antiactivator protein ExsD TMEM191C PF15194.4 T230007_3 - 4.9e-27 94.3 8.2 8.3e-27 93.6 8.2 1.3 1 0 0 1 1 1 1 TMEM191C family TMCO5 PF14992.4 T230007_3 - 0.34 10.3 0.4 0.46 9.9 0.4 1.1 1 0 0 1 1 1 0 TMCO5 family Pentapeptide_2 PF01469.16 T051541_1 - 0.0057 16.4 6.3 0.52 10.1 1.1 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Herpes_BLLF1 PF05109.11 T172828_3 - 0.0016 16.4 10.8 0.007 14.3 1.7 2.1 1 1 1 2 2 2 2 Herpes virus major outer envelope glycoprotein (BLLF1) IncA PF04156.12 T172828_3 - 0.18 11.4 0.0 4.5 6.9 0.0 2.2 1 1 1 2 2 2 0 IncA protein Transposase_1 PF01359.16 T069599_2 - 5.8e-18 64.4 0.2 5.8e-18 64.4 0.2 2.1 2 0 0 2 2 2 1 Transposase (partial DDE domain) rve PF00665.24 T333823_2 - 2e-17 63.3 0.0 4e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T333823_2 - 5e-17 62.0 0.0 7.8e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T333823_2 - 5.8e-14 52.4 0.0 1.3e-13 51.2 0.0 1.6 2 0 0 2 2 2 1 RNase H Gag_MA PF01140.17 T333823_2 - 2.4e-12 46.5 0.1 8.6e-12 44.7 0.0 1.8 2 0 0 2 2 2 1 Matrix protein (MA), p15 zf-H2C2 PF09337.8 T333823_2 - 0.00084 19.4 2.1 0.0019 18.3 2.1 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Gag_p30 PF02093.14 T333823_3 - 2.3e-37 128.4 0.4 3.6e-37 127.8 0.4 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RabGAP-TBC PF00566.16 T199621_3 - 0.0042 16.6 0.0 0.0086 15.6 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Baculo_11_kDa PF06143.9 T257776_2 - 1.4 8.5 4.7 2.6 7.6 4.7 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family BAR_3_WASP_bdg PF10456.7 T018766_1 - 1.8e-16 60.2 0.9 1.5e-08 34.3 0.3 2.3 2 0 0 2 2 2 2 WASP-binding domain of Sorting nexin protein DUF3496 PF12001.6 T018766_1 - 2.4e-16 59.9 7.5 4.3e-16 59.1 7.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3496) BAR_3_WASP_bdg PF10456.7 T018766_3 - 3.8e-13 49.3 0.4 1.7e-12 47.2 0.1 1.9 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein DUF3496 PF12001.6 T018766_3 - 7.6e-09 35.8 0.0 1.3e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3496) DUF1725 PF08333.9 T198204_3 - 0.11 12.1 0.1 0.27 10.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Ig_3 PF13927.4 T069796_3 - 1.5e-34 118.3 0.7 3.1e-09 37.2 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 T069796_3 - 3.7e-27 94.4 0.0 6.3e-08 32.7 0.1 5.4 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 T069796_3 - 2.7e-16 59.4 0.1 0.00049 20.1 0.0 5.8 5 2 0 5 5 5 3 Immunoglobulin domain I-set PF07679.14 T069796_3 - 5.2e-13 48.7 0.0 2.9e-06 27.1 0.0 4.8 4 1 0 4 4 4 3 Immunoglobulin I-set domain C2-set_2 PF08205.10 T069796_3 - 8e-07 28.9 13.7 0.056 13.4 0.0 6.2 5 2 1 6 6 6 2 CD80-like C2-set immunoglobulin domain fn3 PF00041.19 T069796_3 - 2e-06 27.9 0.0 8.5e-06 25.9 0.0 2.1 2 0 0 2 2 2 1 Fibronectin type III domain V-set PF07686.15 T069796_3 - 0.0059 16.6 3.0 22 5.1 0.0 4.6 3 2 2 5 5 5 1 Immunoglobulin V-set domain Gag_p24 PF00607.18 T230564_1 - 1.2e-69 234.1 1.3 1.8e-69 233.6 0.3 1.7 2 0 0 2 2 2 1 gag gene protein p24 (core nucleocapsid protein) Gag_p10 PF02337.15 T230564_1 - 2.5e-27 94.4 0.2 5.1e-27 93.4 0.2 1.5 1 0 0 1 1 1 1 Retroviral GAG p10 protein RVT_thumb PF06817.12 T230564_1 - 1.1e-15 57.0 0.0 2.4e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain dUTPase PF00692.17 T230564_1 - 4.8e-10 39.1 0.0 9.1e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 dUTPase IN_DBD_C PF00552.19 T230564_1 - 2.4e-06 26.6 1.2 4.5e-06 25.7 1.2 1.4 1 0 0 1 1 1 1 Integrase DNA binding domain zf-CCHC PF00098.21 T230564_1 - 4.1e-06 26.5 2.5 1e-05 25.2 2.5 1.7 1 0 0 1 1 1 1 Zinc knuckle GP41 PF00517.15 T230564_1 - 1.7e-05 24.6 0.1 3e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Retroviral envelope protein RVT_1 PF00078.25 T230564_1 - 0.0015 18.0 0.1 0.0026 17.2 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_6 PF15288.4 T230564_1 - 0.078 12.7 2.2 0.098 12.4 0.4 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.4 T230564_1 - 0.15 11.7 1.1 0.32 10.6 1.1 1.5 1 0 0 1 1 1 0 Zinc knuckle rve PF00665.24 T230564_2 - 1e-24 86.9 0.0 2.3e-24 85.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_5 PF14787.4 T230564_2 - 8.7e-19 66.8 7.6 8.7e-19 66.8 7.6 2.6 3 0 0 3 3 3 1 GAG-polyprotein viral zinc-finger Integrase_Zn PF02022.17 T230564_2 - 8.7e-15 54.3 2.7 2.4e-14 52.8 2.7 1.9 1 0 0 1 1 1 1 Integrase Zinc binding domain RNase_H PF00075.22 T230564_2 - 3.6e-08 33.6 0.0 6.7e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T230564_2 - 0.033 13.6 0.1 0.069 12.5 0.1 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_IS240 PF13610.4 T230564_2 - 0.036 14.2 0.0 0.057 13.5 0.0 1.3 1 0 0 1 1 1 0 DDE domain HERV-K_env_2 PF13804.4 T230564_3 - 2.5e-37 128.1 0.1 4.8e-37 127.2 0.1 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein RVT_thumb PF06817.12 T230564_3 - 7.8e-08 31.8 0.4 1.9e-07 30.6 0.4 1.7 1 0 0 1 1 1 1 Reverse transcriptase thumb domain GP41 PF00517.15 T230564_3 - 8.7e-06 25.6 2.1 0.006 16.3 0.0 2.3 2 0 0 2 2 2 2 Retroviral envelope protein RVT_1 PF00078.25 T230564_3 - 2.5e-05 23.8 0.0 3.4e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Borrelia_orfX PF04160.10 T230564_3 - 0.017 15.1 0.4 0.031 14.2 0.4 1.3 1 0 0 1 1 1 0 Orf-X protein RVP PF00077.18 T230564_3 - 0.16 12.1 0.1 1.1 9.5 0.1 2.1 1 1 0 1 1 1 0 Retroviral aspartyl protease SelP_N PF04592.12 T184389_2 - 0.86 8.8 12.3 1.4 8.1 12.3 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Wbp11 PF09429.8 T094022_1 - 0.095 13.0 8.7 0.21 11.9 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 Mit_proteolip PF08039.9 T001126_3 - 0.6 10.3 2.8 1.2 9.4 2.8 1.5 1 0 0 1 1 1 0 Mitochondrial proteolipid DUF1725 PF08333.9 T211563_2 - 1.9e-06 27.3 0.3 4e-06 26.2 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Collagen PF01391.16 T211563_2 - 1.6 8.4 52.4 0.055 13.1 17.4 4.2 2 1 1 3 3 3 0 Collagen triple helix repeat (20 copies) HERV-K_env_2 PF13804.4 T202688_1 - 3.4e-37 127.7 0.2 5.3e-37 127.0 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GP41 PF00517.15 T202688_3 - 3.4e-10 40.0 0.3 6.3e-10 39.1 0.3 1.4 1 0 0 1 1 1 1 Retroviral envelope protein Gag_p30 PF02093.14 T383386_1 - 6.1e-10 38.8 0.1 1e-09 38.1 0.1 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RNase_H PF00075.22 T383386_1 - 0.099 12.7 1.2 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 RNase H DUF4705 PF15788.3 T323224_1 - 6.8 6.8 49.1 0.056 13.5 17.0 7.0 6 1 1 7 7 7 0 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323224_3 - 1.9e-05 24.6 22.5 0.00029 20.9 6.5 7.3 6 2 2 8 8 8 2 Domain of unknown function (DUF4705) Transposase_22 PF02994.12 T288599_1 - 2e-51 174.9 0.4 2e-51 174.9 0.4 2.4 3 0 0 3 3 3 2 L1 transposable element Transposase_22 PF02994.12 T288599_2 - 2.4e-43 148.3 7.0 4.2e-43 147.5 7.0 1.3 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T288599_2 - 9.9e-36 123.2 0.8 6.3e-26 91.1 0.1 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T288599_3 - 7.8e-09 34.8 0.5 1.7e-08 33.7 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Syntaxin-6_N PF09177.9 T288599_3 - 0.14 12.6 3.0 0.29 11.6 3.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal MIP-T3 PF10243.7 T197486_2 - 0.019 13.6 70.4 0.028 13.0 70.4 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 GATase_7 PF13537.4 T383215_2 - 1.1e-09 38.1 0.0 1.8e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.4 T383215_2 - 3e-05 24.1 0.0 5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Mucin-like PF16058.3 T300733_1 - 0.013 15.4 5.1 0.028 14.4 5.1 1.5 1 0 0 1 1 1 0 Mucin-like Herpes_LMP1 PF05297.9 T300733_1 - 6.8 5.6 8.3 11 5.0 8.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Epiglycanin_C PF14654.4 T300733_2 - 7.6e-09 35.4 0.7 7.6e-09 35.4 0.7 1.8 2 0 0 2 2 2 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300733_2 - 2.3e-06 27.5 4.4 5.2e-06 26.3 4.4 1.5 1 0 0 1 1 1 1 Mucin-like DUF4705 PF15788.3 T323204_1 - 2.2e-69 229.3 521.4 3.7e-08 33.3 4.4 49.1 29 10 14 43 43 43 35 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323204_2 - 2.6e-57 190.7 522.6 1.3e-15 57.2 9.2 46.0 27 10 11 38 38 38 25 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323204_3 - 2.8e-79 261.0 501.5 3.6e-17 62.2 8.0 44.9 24 16 19 43 43 43 28 Domain of unknown function (DUF4705) PRP38_assoc PF12871.5 T180252_1 - 0.82 10.1 18.9 2.3 8.7 18.9 1.7 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Hexapep PF00132.22 T359859_1 - 0.026 14.1 0.1 3.1 7.5 0.0 3.6 3 0 0 3 3 3 0 Bacterial transferase hexapeptide (six repeats) Hexapep PF00132.22 T359859_2 - 0.026 14.1 0.1 66 3.3 0.0 4.8 4 1 0 4 4 4 0 Bacterial transferase hexapeptide (six repeats) Hexapep PF00132.22 T359859_3 - 0.063 12.9 0.0 17 5.2 0.0 3.3 3 0 0 3 3 3 0 Bacterial transferase hexapeptide (six repeats) Elf1 PF05129.11 T184599_3 - 0.032 14.2 3.2 11 6.0 0.2 3.7 1 1 0 2 2 2 0 Transcription elongation factor Elf1 like DUF1725 PF08333.9 T067413_3 - 0.0025 17.3 0.2 0.0054 16.2 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) zf-C2H2_7 PF15269.4 T165307_2 - 0.76 9.8 3.5 1.7 8.6 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger TLV_coat PF00429.17 T086906_1 - 1.3e-19 70.2 6.0 9.7e-19 67.3 2.3 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) RVT_1 PF00078.25 T086906_2 - 0.00025 20.5 0.1 0.00042 19.8 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T086906_3 - 9.9e-18 64.6 0.0 1.4e-17 64.1 0.0 1.2 1 0 0 1 1 1 1 RNase H RVP PF00077.18 T086906_3 - 0.004 17.3 0.0 0.0082 16.3 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Transposase_1 PF01359.16 T198709_2 - 8.2e-07 28.7 0.0 1.9e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) MgtE_N PF03448.15 T164820_2 - 0.00097 19.6 0.0 0.0017 18.8 0.0 1.3 1 0 0 1 1 1 1 MgtE intracellular N domain DUF4641 PF15483.4 T376191_1 - 6.7e-165 549.4 20.6 6.7e-165 549.4 20.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4641) Phospho_p8 PF10195.7 T325648_3 - 0.0075 16.6 0.0 0.011 16.1 0.0 1.2 1 0 0 1 1 1 1 DNA-binding nuclear phosphoprotein p8 Exo_endo_phos_2 PF14529.4 T161228_1 - 4.9e-06 26.3 0.8 9e-06 25.4 0.8 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T161228_1 - 0.063 13.4 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T161228_2 - 1.4e-103 346.4 7.3 2.9e-103 345.4 7.3 1.5 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T161228_2 - 1.1e-18 67.4 0.8 1.1e-08 34.8 0.0 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T161228_3 - 2e-17 63.3 0.0 3.4e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p24 PF00607.18 T097015_1 - 1.5e-30 106.4 0.0 2.2e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) HERV-K_env_2 PF13804.4 T097015_2 - 7.7e-51 172.1 0.2 1.2e-50 171.5 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_REC PF15695.3 T097015_2 - 0.00064 19.6 0.7 0.0012 18.7 0.7 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 GP41 PF00517.15 T097015_3 - 1.6e-14 54.1 5.8 3.2e-14 53.1 5.8 1.4 1 0 0 1 1 1 1 Retroviral envelope protein Fusion_gly PF00523.16 T097015_3 - 0.048 11.8 0.1 0.068 11.3 0.1 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 KSR1-SAM PF13543.4 T018600_3 - 1.5e-06 28.2 0.5 2.4e-06 27.6 0.5 1.2 1 0 0 1 1 1 1 SAM like domain present in kinase suppressor RAS 1 Exo_endo_phos_2 PF14529.4 T264771_3 - 6e-07 29.2 0.9 1.6e-06 27.8 0.9 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF4391 PF14335.4 T264771_3 - 0.00034 20.3 5.8 0.00078 19.1 5.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4391) Exo_endo_phos PF03372.21 T264771_3 - 0.071 13.2 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.25 T132396_1 - 1.5e-11 44.1 0.2 2.3e-11 43.5 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1777 PF08648.10 T111052_1 - 0.0042 17.2 17.6 0.01 16.0 17.6 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1777) CDC45 PF02724.12 T111052_1 - 0.11 10.6 5.5 0.16 10.1 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_polI_A34 PF08208.9 T111052_1 - 0.21 11.6 10.7 0.44 10.5 0.7 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Connexin PF00029.17 T111052_1 - 3.9 7.0 4.8 1.7 8.2 0.9 1.9 2 0 0 2 2 2 0 Connexin DUF1777 PF08648.10 T111052_2 - 6.4e-06 26.4 5.6 1.2e-05 25.5 5.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) CDC45 PF02724.12 T111052_2 - 0.15 10.2 5.5 0.21 9.7 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Eapp_C PF10238.7 T111052_2 - 4.1 7.4 12.6 0.16 11.9 4.3 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF1777 PF08648.10 T111052_3 - 0.00061 20.0 12.1 0.0012 19.0 12.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) AAA_11 PF13086.4 T111052_3 - 0.047 13.3 0.2 0.068 12.8 0.2 1.3 1 0 0 1 1 1 0 AAA domain CDC45 PF02724.12 T111052_3 - 0.62 8.2 5.5 0.76 7.9 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1725 PF08333.9 T198203_3 - 0.1 12.1 0.1 0.26 10.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T161229_1 - 3.6e-103 345.1 8.5 7.5e-103 344.1 8.5 1.5 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T161229_1 - 1e-18 67.6 0.8 1e-08 34.9 0.0 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T161229_2 - 1.9e-17 63.4 0.0 3.2e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.4 T161229_3 - 4.6e-06 26.4 0.8 8.5e-06 25.5 0.8 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T161229_3 - 0.059 13.5 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T038093_1 - 1e-130 435.7 18.9 1e-130 435.7 18.9 1.8 2 0 0 2 2 2 1 L1 transposable element Exo_endo_phos PF03372.21 T038093_1 - 1.1e-07 32.0 0.0 2.3e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family KLRAQ PF10205.7 T038093_1 - 0.00047 20.2 3.3 0.0023 18.0 3.3 2.2 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein DUF1725 PF08333.9 T038093_1 - 0.14 11.7 0.3 0.39 10.3 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T038093_2 - 3.6e-44 150.8 3.4 5.5e-44 150.2 3.4 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Humanin PF15040.4 T117122_2 - 5 6.6 5.7 9.4 5.7 1.0 2.6 2 0 0 2 2 2 0 Humanin family Transposase_1 PF01359.16 T016860_3 - 1.1e-06 28.3 0.0 4.9e-06 26.2 0.0 1.9 2 0 0 2 2 2 1 Transposase (partial DDE domain) RNase_H PF00075.22 T377270_1 - 7.5e-07 29.3 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T377270_2 - 7.9e-17 61.4 0.0 1.2e-16 60.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.8 T377270_2 - 3.5e-08 33.4 0.7 3.5e-08 33.4 0.7 2.2 2 0 0 2 2 2 1 His(2)-Cys(2) zinc finger TLV_coat PF00429.17 T377270_2 - 0.002 16.8 1.9 0.069 11.7 0.4 2.4 2 1 0 2 2 2 2 ENV polyprotein (coat polyprotein) rve PF00665.24 T377270_3 - 3.2e-11 43.3 0.0 5e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.4 T377270_3 - 0.026 14.2 0.0 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Transposase_22 PF02994.12 T267830_3 - 5.7e-73 245.7 20.2 1e-72 244.9 20.2 1.4 1 0 0 1 1 1 1 L1 transposable element Seryl_tRNA_N PF02403.20 T267830_3 - 0.00022 21.3 7.9 0.0006 19.9 7.9 1.8 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.9 T267830_3 - 0.00028 21.3 7.9 0.0012 19.2 7.9 2.1 1 0 0 1 1 1 1 Syntaxin 6, N-terminal EzrA PF06160.10 T267830_3 - 0.00043 18.5 10.6 0.0023 16.1 8.0 1.9 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA ArAE_2_N PF10337.7 T267830_3 - 0.0017 17.3 0.3 0.0023 16.9 0.3 1.1 1 0 0 1 1 1 1 Putative ER transporter, 6TM, N-terminal GAS PF13851.4 T267830_3 - 0.013 14.8 12.7 0.03 13.6 12.7 1.6 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.9 T267830_3 - 0.013 15.5 19.3 0.37 10.8 19.3 2.1 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) APG6 PF04111.10 T267830_3 - 0.038 13.2 12.7 0.061 12.6 12.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Reo_sigmaC PF04582.10 T267830_3 - 0.057 12.7 0.1 0.083 12.1 0.1 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF812 PF05667.9 T267830_3 - 0.15 10.8 17.7 0.21 10.3 17.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Vps51 PF08700.9 T267830_3 - 0.15 12.0 1.7 0.53 10.3 1.7 2.0 1 0 0 1 1 1 0 Vps51/Vps67 DUF1515 PF07439.9 T267830_3 - 0.15 11.9 6.0 1.7 8.6 1.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Phage_GP20 PF06810.9 T267830_3 - 0.15 11.7 5.9 0.36 10.5 5.6 1.7 1 1 0 1 1 1 0 Phage minor structural protein GP20 TBPIP PF07106.11 T267830_3 - 0.16 11.6 15.0 0.37 10.4 8.1 2.4 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) IncA PF04156.12 T267830_3 - 0.23 11.1 11.8 0.47 10.1 11.8 1.5 1 0 0 1 1 1 0 IncA protein GCN5L1 PF06320.11 T267830_3 - 0.24 11.4 12.0 0.031 14.3 5.2 2.5 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) BLOC1_2 PF10046.7 T267830_3 - 0.25 11.6 5.0 0.6 10.3 5.0 1.7 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2203 PF09969.7 T267830_3 - 0.3 11.7 9.6 0.1 13.2 2.2 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF2730 PF10805.6 T267830_3 - 0.34 10.9 3.5 0.41 10.6 1.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DUF1664 PF07889.10 T267830_3 - 0.4 10.6 3.3 0.91 9.4 2.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Cytochrom_B562 PF07361.9 T267830_3 - 0.41 11.2 3.8 0.32 11.5 0.3 2.3 1 1 1 2 2 2 0 Cytochrome b562 Spectrin PF00435.19 T267830_3 - 0.43 11.0 10.0 0.17 12.3 5.3 2.0 1 1 1 2 2 2 0 Spectrin repeat DUF4250 PF14056.4 T267830_3 - 0.62 9.9 2.4 0.82 9.5 0.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) DUF342 PF03961.11 T267830_3 - 1.3 7.4 6.3 2 6.8 6.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) ZapB PF06005.10 T267830_3 - 1.4 9.3 15.6 0.92 9.9 6.9 2.5 2 0 0 2 2 2 0 Cell division protein ZapB Occludin_ELL PF07303.11 T267830_3 - 1.7 9.3 7.2 15 6.2 0.4 2.6 1 1 1 2 2 2 0 Occludin homology domain ADIP PF11559.6 T267830_3 - 2.4 8.1 17.5 0.17 11.9 8.9 2.9 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.7 T267830_3 - 2.6 6.9 15.5 0.38 9.6 11.4 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prominin PF05478.9 T267830_3 - 2.9 5.6 7.9 8.2 4.1 7.9 1.3 1 1 0 1 1 1 0 Prominin FlaC_arch PF05377.9 T267830_3 - 3.3 8.1 10.0 14 6.0 1.0 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) WD40_alt PF14077.4 T267830_3 - 3.5 7.4 5.6 15 5.4 0.9 2.7 2 1 0 2 2 2 0 Alternative WD40 repeat motif HSBP1 PF06825.10 T267830_3 - 4.9 7.0 7.4 7.1 6.5 0.1 3.0 3 0 0 3 3 3 0 Heat shock factor binding protein 1 TMF_DNA_bd PF12329.6 T267830_3 - 5.4 7.0 16.9 31 4.5 8.2 3.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding KLRAQ PF10205.7 T267830_3 - 6.3 7.0 17.8 0.033 14.3 6.4 2.6 2 1 1 3 3 2 0 Predicted coiled-coil domain-containing protein Fzo_mitofusin PF04799.11 T267830_3 - 7.2 6.0 6.2 2.3 7.6 2.0 2.0 1 1 1 2 2 2 0 fzo-like conserved region Macoilin PF09726.7 T267830_3 - 7.9 4.8 21.5 7.4 4.9 20.2 1.4 1 1 0 1 1 1 0 Transmembrane protein Prefoldin_2 PF01920.18 T267830_3 - 9.3 6.1 14.8 11 5.9 5.7 2.7 1 1 0 2 2 2 0 Prefoldin subunit Filament PF00038.19 T078926_2 - 3.8e-41 141.5 14.0 5e-41 141.1 14.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein BRE1 PF08647.9 T078926_2 - 0.066 13.2 10.2 0.27 11.2 3.0 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase MscS_porin PF12795.5 T078926_2 - 0.15 11.4 9.8 0.23 10.9 9.8 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain CALCOCO1 PF07888.9 T078926_2 - 0.17 10.3 11.8 0.24 9.8 11.8 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.9 T078926_2 - 0.57 8.9 12.3 1.5 7.5 12.0 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.5 T078926_2 - 1.2 9.1 12.9 1.9 8.5 12.9 1.2 1 0 0 1 1 1 0 Tropomyosin like Muted PF14942.4 T078926_2 - 1.6 8.9 10.2 2.3 8.4 10.2 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein ADIP PF11559.6 T078926_2 - 4.8 7.1 12.6 6.3 6.7 11.2 1.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DivIVA PF05103.11 T078926_2 - 5.1 7.1 10.0 7.5 6.5 10.0 1.2 1 0 0 1 1 1 0 DivIVA protein Filament PF00038.19 T078926_3 - 0.0012 18.3 0.0 0.0016 18.0 0.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein AAA_15 PF13175.4 T375848_1 - 3.3 7.1 24.4 4.8 6.6 24.4 1.1 1 0 0 1 1 1 0 AAA ATPase domain DUF1510 PF07423.9 T375848_3 - 2.2e-05 23.9 11.2 2.2e-05 23.9 11.2 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1510) Neur_chan_memb PF02932.14 T375848_3 - 0.025 14.5 11.7 0.042 13.8 11.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MIP-T3 PF10243.7 T375848_3 - 0.36 9.3 79.0 0.52 8.8 79.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 IncA PF04156.12 T375848_3 - 0.54 9.9 13.9 2.4 7.8 13.9 1.8 1 1 0 1 1 1 0 IncA protein SID-1_RNA_chan PF13965.4 T375848_3 - 1.7 6.9 6.2 3.3 5.9 6.2 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 AAA_15 PF13175.4 T375848_3 - 4.1 6.8 27.5 6.6 6.1 27.5 1.2 1 0 0 1 1 1 0 AAA ATPase domain Presenilin PF01080.15 T375848_3 - 5.4 5.5 31.9 9.3 4.7 31.9 1.3 1 0 0 1 1 1 0 Presenilin HERV-K_env_2 PF13804.4 T202691_1 - 3.2e-37 127.7 0.2 5.3e-37 127.0 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GP41 PF00517.15 T202691_3 - 3.6e-10 39.9 0.3 6.2e-10 39.1 0.3 1.3 1 0 0 1 1 1 1 Retroviral envelope protein DUF1777 PF08648.10 T316532_1 - 1.2e-05 25.6 13.6 2.1e-05 24.7 13.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) CDC45 PF02724.12 T316532_1 - 3.1 5.9 10.6 4.5 5.3 10.6 1.1 1 0 0 1 1 1 0 CDC45-like protein PRP38_assoc PF12871.5 T316532_1 - 4.3 7.8 42.0 8.6 6.9 42.0 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF1777 PF08648.10 T316532_2 - 5.3e-05 23.4 19.1 0.00016 21.9 19.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) DUF1725 PF08333.9 T182471_3 - 0.045 13.3 0.5 0.08 12.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Gag_p30 PF02093.14 T065988_1 - 5.6e-16 58.6 0.0 9.2e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T065988_1 - 0.089 12.9 0.0 0.84 9.8 0.0 2.2 2 0 0 2 2 2 0 Retroviral aspartyl protease RNase_H PF00075.22 T065988_2 - 3.8e-17 62.7 0.0 6.7e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 RNase H rve PF00665.24 T065988_2 - 1.5e-05 25.0 0.0 2.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T065988_2 - 0.025 14.0 0.1 0.071 12.5 0.1 1.7 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T065988_3 - 0.00027 20.4 0.0 0.00042 19.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein DUF2967 PF11179.6 T061578_3 - 4 6.7 9.3 6.5 6.0 9.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Spt20 PF12090.6 T061578_3 - 7.7 5.9 7.5 13 5.2 7.5 1.2 1 0 0 1 1 1 0 Spt20 family Transposase_22 PF02994.12 T376918_3 - 5.3e-27 94.5 0.1 8.5e-27 93.8 0.1 1.3 1 0 0 1 1 1 1 L1 transposable element PBAN PF05874.9 T337285_3 - 0.018 14.8 9.6 1 9.1 1.1 2.6 1 1 1 2 2 2 0 Pheromone biosynthesis activating neuropeptide (PBAN) RVT_1 PF00078.25 T338389_2 - 1.1e-16 61.0 0.0 1.7e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T338389_2 - 0.034 14.2 0.0 0.064 13.3 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain VCX_VCY PF15231.4 T381757_3 - 9.1e-06 26.2 0.1 1.9e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 Variable charge X/Y family DUF1777 PF08648.10 T027560_1 - 0.0046 17.1 25.2 0.0046 17.1 25.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1777) CDC45 PF02724.12 T027560_3 - 0.025 12.8 12.4 0.036 12.3 12.4 1.1 1 0 0 1 1 1 0 CDC45-like protein NARP1 PF12569.6 T027560_3 - 7.9 5.1 17.8 11 4.6 17.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MIP-T3 PF10243.7 T027560_3 - 8.8 4.8 34.3 13 4.2 34.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 GPAT_N PF14829.4 T383635_2 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal zf-CCHC PF00098.21 T281820_1 - 0.0031 17.4 5.8 0.012 15.6 1.0 2.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T281820_1 - 0.068 12.8 14.8 0.12 12.0 3.6 2.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger RVP PF00077.18 T281820_2 - 0.00016 21.7 0.0 0.00031 20.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease TLV_coat PF00429.17 T281820_3 - 2.4e-13 49.5 0.1 3.6e-13 48.9 0.1 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RNase_H PF00075.22 T281820_3 - 1.6e-09 38.0 0.0 2.5e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T281820_3 - 2.8e-08 33.4 0.1 4.6e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Wbp11 PF09429.8 T094003_3 - 0.088 13.1 8.7 0.2 12.0 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 MSG PF02349.13 T315671_1 - 0.0099 15.9 6.2 11 6.2 0.1 3.6 1 1 1 2 2 2 2 Major surface glycoprotein Thx PF17070.3 T241199_1 - 0.083 12.9 1.2 0.23 11.5 1.2 1.7 1 0 0 1 1 1 0 30S ribosomal protein Thx CCDC144C PF14915.4 T018828_1 - 6.7e-29 100.8 16.4 6.7e-29 100.8 16.4 2.4 3 0 0 3 3 3 1 CCDC144C protein coiled-coil region BAR_3_WASP_bdg PF10456.7 T018828_1 - 4.1e-16 59.0 1.1 2e-08 33.9 0.4 2.2 2 0 0 2 2 2 2 WASP-binding domain of Sorting nexin protein DUF3496 PF12001.6 T018828_1 - 1.6e-15 57.3 6.5 1.6e-15 57.3 6.5 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3496) CCDC144C PF14915.4 T018828_2 - 2.9e-29 102.0 13.6 2.9e-29 102.0 13.6 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018828_2 - 4.2 7.2 19.2 0.027 14.4 1.1 2.3 2 0 0 2 2 2 0 Laminin Domain II BAR_3_WASP_bdg PF10456.7 T018828_3 - 1e-13 51.2 0.3 9.1e-13 48.1 0.1 2.1 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein CCDC144C PF14915.4 T018828_3 - 6.6e-07 28.6 3.0 9.3e-07 28.1 3.0 1.2 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018828_3 - 0.00043 20.5 2.1 0.00052 20.2 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3496) Collagen PF01391.16 T316888_1 - 7.3e-06 25.5 11.7 7.3e-06 25.5 11.7 4.2 4 0 0 4 4 4 1 Collagen triple helix repeat (20 copies) zf-CCHC_4 PF14392.4 T316888_3 - 0.01 15.4 12.1 2.3 7.8 0.2 4.9 3 2 2 5 5 5 0 Zinc knuckle DUF1725 PF08333.9 T035462_1 - 0.0019 17.7 0.1 0.0033 16.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Dynein_heavy PF03028.13 T085626_3 - 3.2e-11 42.1 0.0 4.7e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor RNase_H PF00075.22 T172338_1 - 3e-05 24.1 0.0 5.6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T343314_2 - 2.9e-12 46.4 0.0 5e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein rve PF00665.24 T343314_2 - 0.002 18.2 0.0 0.0037 17.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Exo_endo_phos PF03372.21 T057283_3 - 3.4e-09 36.8 0.0 5.2e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T057283_3 - 2.5e-06 26.5 0.2 3.5e-06 26.0 0.2 1.1 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T057283_3 - 3.8e-05 23.4 0.6 6.1e-05 22.7 0.2 1.6 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase GAIN PF16489.3 T229026_1 - 1.1e-09 38.0 0.0 1.5e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Ig_3 PF13927.4 T022850_1 - 0.0019 18.7 0.1 2.4 8.7 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 T022850_1 - 0.017 15.1 0.0 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin I-set domain V-set PF07686.15 T022850_1 - 0.034 14.2 3.4 0.087 12.8 0.0 2.5 3 0 0 3 3 3 0 Immunoglobulin V-set domain DUF3704 PF12488.6 T100135_2 - 0.17 11.4 4.0 0.35 10.4 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) RIBIOP_C PF04950.10 T100135_3 - 9.6e-08 31.7 0.0 1.5e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Transposase_22 PF02994.12 T103744_2 - 2.1e-142 474.2 20.5 2.8e-142 473.8 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103744_2 - 0.029 14.5 0.0 0.055 13.6 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103744_2 - 0.058 13.0 10.5 0.11 12.2 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103744_2 - 0.059 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103744_2 - 0.34 11.4 5.0 0.68 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103744_2 - 0.42 9.8 12.3 0.73 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103744_2 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103744_2 - 2.7 8.1 7.4 4.8 7.4 6.6 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Potassium_chann PF11404.6 T008727_2 - 0.61 9.8 4.3 2.6 7.8 0.3 2.6 2 0 0 2 2 2 0 Potassium voltage-gated channel RNase_H PF00075.22 T294834_2 - 3.5e-22 79.0 0.0 7.6e-22 77.9 0.0 1.5 2 0 0 2 2 2 1 RNase H RVT_1 PF00078.25 T294834_2 - 8.2e-20 71.1 0.0 2.1e-19 69.8 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.8 T294834_2 - 1e-07 31.9 0.1 2.6e-07 30.7 0.1 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger DUF2726 PF10881.6 T165132_3 - 5.3e-07 29.5 28.5 1.2 8.9 0.1 8.9 1 1 10 11 11 11 7 Protein of unknown function (DUF2726) DUF4831 PF16115.3 T165132_3 - 0.013 14.4 0.0 17 4.2 0.0 3.9 3 2 1 5 5 5 0 Domain of unknown function (DUF4831) PDE8 PF08629.8 T165132_3 - 0.14 12.0 44.2 3.8 7.5 0.1 13.6 12 5 2 15 15 15 0 PDE8 phosphodiesterase DUF982 PF06169.10 T079591_3 - 5.3 7.0 6.1 11 5.9 6.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF982) PSI_PsaJ PF01701.16 T052799_2 - 0.44 11.0 3.1 0.75 10.3 0.1 2.5 2 0 0 2 2 2 0 Photosystem I reaction centre subunit IX / PsaJ Transposase_1 PF01359.16 T351135_1 - 0.023 14.4 0.1 0.073 12.8 0.1 1.8 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_1 PF01359.16 T351135_2 - 4.6e-21 74.3 7.5 1.4e-20 72.8 4.6 2.6 2 0 0 2 2 2 1 Transposase (partial DDE domain) DDE_3 PF13358.4 T351135_2 - 0.0026 17.4 0.4 0.0047 16.6 0.4 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BEN PF10523.7 T351135_2 - 0.055 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 BEN domain Transposase_1 PF01359.16 T287708_3 - 6.3e-08 32.2 0.0 1.4e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) Dynein_heavy PF03028.13 T085621_2 - 3.1e-11 42.1 0.0 4.5e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor RVT_1 PF00078.25 T091114_2 - 1.7e-07 30.9 0.0 2.7e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lbh PF15317.4 T110889_1 - 2.8e-08 34.4 0.3 5e-08 33.6 0.3 1.3 1 0 0 1 1 1 1 Cardiac transcription factor regulator, Developmental protein Transposase_22 PF02994.12 T187638_1 - 6e-123 410.2 7.4 8.9e-123 409.6 7.4 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T187638_1 - 1e-08 34.9 1.0 2.5e-08 33.7 1.0 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T187638_1 - 4.9e-08 33.1 0.0 1.3e-07 31.7 0.0 1.8 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CCDC66 PF15236.4 T187638_1 - 0.54 10.0 7.9 1.1 8.9 7.9 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 Tektin PF03148.12 T124750_1 - 0.0032 16.2 0.1 0.0042 15.8 0.1 1.0 1 0 0 1 1 1 1 Tektin family Transposase_22 PF02994.12 T089163_1 - 4.5e-51 173.7 0.6 9e-51 172.7 0.6 1.4 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T089163_1 - 9.9e-07 28.4 0.1 0.046 13.1 0.0 2.2 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DivIC PF04977.13 T089163_1 - 0.085 12.5 0.4 2 8.1 0.1 2.5 2 0 0 2 2 2 0 Septum formation initiator RVT_1 PF00078.25 T089163_2 - 3e-19 69.3 0.3 5.3e-19 68.5 0.3 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T089163_2 - 0.046 13.8 0.0 0.097 12.8 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Leader_CPA1 PF08252.9 T089163_2 - 0.31 10.4 3.6 0.71 9.2 3.6 1.6 1 0 0 1 1 1 0 arg-2/CPA1 leader peptide Transposase_22 PF02994.12 T089163_3 - 1.1e-38 132.9 11.1 4.6e-37 127.6 4.7 2.3 2 0 0 2 2 2 2 L1 transposable element DUF4705 PF15788.3 T323251_1 - 0.011 15.8 35.3 0.028 14.5 15.6 5.6 4 1 0 4 4 4 0 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323251_3 - 3.4e-05 23.8 22.1 0.00028 20.9 6.0 6.6 5 2 2 7 7 7 2 Domain of unknown function (DUF4705) Sec8_exocyst PF04048.12 T111718_1 - 0.13 12.1 1.6 0.19 11.5 1.6 1.1 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Transposase_22 PF02994.12 T111718_2 - 0.0014 17.4 3.8 0.0016 17.3 2.2 1.7 2 0 0 2 2 2 1 L1 transposable element Arylesterase PF01731.18 T381604_2 - 0.047 13.8 0.0 0.09 12.9 0.0 1.4 1 0 0 1 1 1 0 Arylesterase DUF1725 PF08333.9 T293624_1 - 0.0006 19.3 2.1 0.0014 18.1 2.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T293624_1 - 0.00077 18.9 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mit_proteolip PF08039.9 T293624_1 - 0.57 10.4 5.3 1.2 9.3 5.3 1.5 1 0 0 1 1 1 0 Mitochondrial proteolipid Transposase_22 PF02994.12 T293624_2 - 1.4e-26 93.1 5.0 2.7e-24 85.6 1.8 2.2 2 0 0 2 2 2 2 L1 transposable element Mit_proteolip PF08039.9 T293624_2 - 1.5 9.0 7.2 1.2 9.3 5.0 1.9 2 0 0 2 2 2 0 Mitochondrial proteolipid RVT_1 PF00078.25 T293624_3 - 2e-22 79.7 3.0 3.8e-22 78.8 3.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mit_proteolip PF08039.9 T293624_3 - 0.82 9.9 5.0 2.1 8.6 5.0 1.6 1 0 0 1 1 1 0 Mitochondrial proteolipid TetR_C_12 PF16914.3 T185624_2 - 1.9 8.5 6.3 21 5.2 0.3 2.7 1 1 2 3 3 3 0 Bacterial transcriptional repressor C-terminal RVT_1 PF00078.25 T263457_1 - 9.2e-27 93.9 0.1 1.4e-26 93.3 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T263457_2 - 1.8e-103 346.1 7.5 3.8e-103 345.0 7.5 1.5 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T263457_2 - 8e-11 41.7 0.3 2.5e-10 40.2 0.3 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T263457_2 - 7e-10 39.0 0.0 1.4e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T263457_2 - 2.7e-08 33.5 0.4 8.4e-08 32.0 0.4 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF1725 PF08333.9 T263457_2 - 2.9e-08 33.0 0.7 8e-08 31.6 0.7 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T263457_3 - 7.6e-30 103.8 15.7 1.2e-29 103.2 15.7 1.2 1 0 0 1 1 1 1 L1 transposable element Seryl_tRNA_N PF02403.20 T263457_3 - 0.00061 19.9 4.6 0.0012 19.0 4.6 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.9 T263457_3 - 0.0032 17.9 4.9 0.0032 17.9 4.9 1.8 2 0 0 2 2 2 1 Syntaxin 6, N-terminal Arylesterase PF01731.18 T381592_2 - 0.022 14.8 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 Arylesterase Colipase-like PF15083.4 T090354_1 - 4.3e-46 154.8 26.6 3e-38 129.7 13.6 2.5 1 1 1 2 2 2 2 Colipase-like rve PF00665.24 T023854_1 - 2.5e-14 53.4 0.0 4e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain dUTPase PF00692.17 T023854_3 - 6.7e-14 51.5 0.0 1.1e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 dUTPase Transposase_22 PF02994.12 T012234_1 - 2.1e-26 92.6 6.6 5.7e-25 87.8 2.1 2.5 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T012234_1 - 0.02 14.4 0.3 0.045 13.3 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T012234_2 - 2.9e-38 131.5 1.9 2.4e-29 102.3 0.3 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T012234_3 - 3.7e-26 91.7 16.9 1.2e-19 70.3 0.0 3.7 4 0 0 4 4 4 3 L1 transposable element PBAN PF05874.9 T337286_3 - 0.023 14.4 9.7 1.2 8.8 2.6 2.6 1 1 1 2 2 2 0 Pheromone biosynthesis activating neuropeptide (PBAN) MIP-T3 PF10243.7 T197485_1 - 0.017 13.8 70.4 0.025 13.2 70.4 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Imm35 PF15567.4 T123585_3 - 0.019 15.0 0.4 26 4.9 0.0 4.8 5 0 0 5 5 5 0 Immunity protein 35 Ig_3 PF13927.4 T022815_2 - 0.0013 19.1 0.3 2.1 8.9 0.2 2.7 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 T022815_2 - 0.0077 16.2 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 T022815_2 - 0.06 13.3 0.0 1.4 8.9 0.0 2.7 3 0 0 3 3 3 0 Immunoglobulin I-set domain DUF788 PF05620.9 T110831_2 - 0.066 13.0 0.2 0.11 12.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF788) Fibrinogen_BP PF08017.9 T359274_1 - 1.5e-25 89.4 23.1 4.2e-16 58.3 0.5 4.0 3 1 0 3 3 3 3 Fibrinogen binding protein Fibrinogen_BP PF08017.9 T359274_2 - 1.2e-14 53.4 1.2 1.7e-07 29.9 0.2 2.8 3 0 0 3 3 3 2 Fibrinogen binding protein RVT_1 PF00078.25 T033517_1 - 6.9e-30 104.1 1.0 9.8e-18 64.3 0.1 2.2 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) UPF0184 PF03670.11 T033517_1 - 0.056 13.7 0.4 0.1 12.8 0.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Transposase_22 PF02994.12 T033517_2 - 1.4e-60 205.0 9.8 3.2e-60 203.8 9.8 1.6 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T033517_2 - 0.0011 18.7 0.2 0.003 17.3 0.2 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF1725 PF08333.9 T033517_2 - 0.043 13.4 0.3 0.34 10.5 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1725) DUF3704 PF12488.6 T033517_3 - 1 9.0 5.7 2.3 7.8 5.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) Plasmodium_Vir PF05795.9 T305698_3 - 0.031 13.6 7.9 0.05 12.9 7.9 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein rve PF00665.24 T089226_3 - 2.6e-07 30.7 0.0 5.5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.4 T089226_3 - 0.01 15.4 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.25 T355542_1 - 2.2e-33 115.5 1.5 4.9e-33 114.4 0.1 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T355542_2 - 3.1e-23 82.1 0.2 4.6e-23 81.5 0.2 1.3 1 0 0 1 1 1 1 L1 transposable element RNase_H PF00075.22 T338183_1 - 1.3e-16 61.0 0.0 2.1e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T338183_2 - 4.1e-17 62.3 0.0 6.5e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T338183_2 - 3.1e-15 56.3 0.0 5.2e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T338183_2 - 5.3e-08 32.9 0.1 2e-07 31.0 0.1 2.1 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger DUF1725 PF08333.9 T338183_3 - 0.036 13.6 0.1 0.073 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) zf-H2C2 PF09337.8 T043679_3 - 0.00012 22.2 0.3 0.00023 21.2 0.3 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Lamprin PF06403.9 T031443_2 - 0.13 12.1 2.1 3.5 7.4 0.2 4.0 4 0 0 4 4 4 0 Lamprin DUF1725 PF08333.9 T031443_3 - 4.1e-05 23.0 0.3 0.00029 20.3 0.3 2.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Lamprin PF06403.9 T031443_3 - 0.085 12.7 1.6 2.8 7.7 2.6 3.1 4 0 0 4 4 4 0 Lamprin Chorion_1 PF01723.14 T031443_3 - 8.9 6.1 6.2 25 4.6 6.2 1.8 1 0 0 1 1 1 0 Chorion protein RNase_H PF00075.22 T236791_1 - 9.3e-09 35.5 0.1 1.7e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T236791_2 - 9.4e-27 93.8 1.5 1.8e-25 89.6 0.1 2.2 2 0 0 2 2 2 1 Gag P30 core shell protein Transposase_22 PF02994.12 T236791_2 - 8.7e-13 47.7 0.5 1.3e-12 47.1 0.5 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T236791_2 - 4.6e-10 39.2 0.0 6.8e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_MA PF01140.17 T236791_2 - 0.0013 18.3 0.0 0.0031 17.0 0.0 1.6 1 0 0 1 1 1 1 Matrix protein (MA), p15 RVT_1 PF00078.25 T236791_3 - 0.0029 17.0 0.0 0.0046 16.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1325 PF07039.9 T129488_3 - 0.065 13.2 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 SGF29 tudor-like domain Mucin-like PF16058.3 T183228_2 - 3.2e-09 36.6 18.3 3.2e-06 27.0 6.5 2.3 2 1 1 3 3 3 2 Mucin-like Pro-rich PF15240.4 T183228_2 - 0.32 11.2 13.2 0.6 10.3 13.2 1.5 1 0 0 1 1 1 0 Proline-rich PHO4 PF01384.18 T236009_3 - 6.3e-06 25.3 0.3 0.0015 17.5 0.0 2.5 2 0 0 2 2 2 2 Phosphate transporter family SUR7 PF06687.10 T236009_3 - 6.6 6.2 0.0 6.6 6.2 0.0 3.1 3 1 0 3 3 3 0 SUR7/PalI family RVT_1 PF00078.25 T291132_1 - 1.9e-45 155.0 2.5 2.8e-45 154.4 2.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSBP1 PF06825.10 T291132_1 - 0.0017 18.1 1.0 0.0033 17.2 1.0 1.5 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Plasmid_stab_B PF10784.7 T170295_3 - 0.074 12.8 0.1 0.23 11.2 0.1 1.8 2 0 0 2 2 2 0 Plasmid stability protein PTPRCAP PF15713.3 T008080_2 - 0.058 13.5 34.5 0.081 13.1 34.5 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.12 T008080_2 - 0.17 10.1 24.8 0.21 9.7 24.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.15 T008080_2 - 0.27 11.2 5.0 0.38 10.7 5.0 1.3 1 0 0 1 1 1 0 DDHD domain SDA1 PF05285.10 T008080_2 - 0.41 9.9 34.7 0.59 9.4 34.7 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.10 T008080_2 - 4.6 5.2 40.6 5.7 4.9 40.6 1.0 1 0 0 1 1 1 0 Nop14-like family DUF913 PF06025.10 T008080_2 - 7 5.4 12.4 9 5.0 12.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RNA_pol_Rpc4 PF05132.12 T008080_3 - 0.0024 18.2 13.4 0.0035 17.7 13.4 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 NPR3 PF03666.11 T008080_3 - 0.036 12.7 26.7 0.046 12.4 26.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DDHD PF02862.15 T008080_3 - 0.042 13.8 11.4 0.05 13.6 11.4 1.1 1 0 0 1 1 1 0 DDHD domain RP-C_C PF11800.6 T008080_3 - 0.045 13.7 7.2 0.056 13.4 7.2 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4228 PF14009.4 T008080_3 - 0.064 13.6 9.1 0.085 13.2 9.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Otopetrin PF03189.11 T008080_3 - 0.091 11.4 2.7 0.099 11.3 2.7 1.1 1 0 0 1 1 1 0 Otopetrin Zip PF02535.20 T008080_3 - 0.58 9.2 13.3 0.72 8.9 13.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.15 T008080_3 - 1.1 7.8 19.0 1.5 7.4 19.0 1.1 1 0 0 1 1 1 0 Presenilin AAA_11 PF13086.4 T008080_3 - 1.5 8.3 23.4 1.9 8.0 23.4 1.1 1 0 0 1 1 1 0 AAA domain SLC12 PF03522.13 T008080_3 - 1.6 7.6 20.6 2 7.2 20.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 VID27 PF08553.8 T008080_3 - 4.6 5.5 22.3 6.1 5.1 22.3 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein Ndc1_Nup PF09531.8 T008080_3 - 4.7 5.6 8.3 5.4 5.4 8.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SpoIIP PF07454.9 T008080_3 - 6.1 6.1 22.2 8.4 5.6 22.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.6 T008080_3 - 9.3 4.8 24.4 13 4.3 24.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2126 PF09899.7 T008080_3 - 9.9 4.0 10.0 12 3.7 10.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) MdoG PF04349.10 T125875_2 - 0.041 12.7 0.4 0.061 12.1 0.4 1.1 1 0 0 1 1 1 0 Periplasmic glucan biosynthesis protein, MdoG CCDC144C PF14915.4 T018734_1 - 6.6e-61 206.0 37.8 5.3e-36 124.2 14.1 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018734_1 - 0.009 15.9 1.1 0.009 15.9 1.1 2.9 3 0 0 3 3 3 1 Laminin Domain II CCDC144C PF14915.4 T018734_2 - 8.5e-17 61.1 9.6 8.5e-17 61.1 9.6 1.5 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018734_2 - 5.7e-09 36.2 0.0 5.7e-09 36.2 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3496) DUF3496 PF12001.6 T018734_3 - 8.6e-17 61.4 7.5 1.8e-16 60.3 7.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3496) Ank_2 PF12796.5 T040979_2 - 0.0014 19.0 0.0 0.0034 17.8 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 T040979_2 - 0.0062 16.8 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.4 T040979_2 - 0.0067 16.7 0.0 0.015 15.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.4 T040979_2 - 0.013 15.7 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Toxin_23 PF08093.9 T026763_2 - 0.042 13.9 1.0 0.11 12.5 1.0 1.7 1 0 0 1 1 1 0 Magi 5 toxic peptide family DUF1725 PF08333.9 T026763_3 - 2.5e-09 36.4 0.8 4.7e-09 35.5 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) dUTPase PF00692.17 T023851_1 - 4.7e-13 48.8 0.0 7.9e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 dUTPase rve PF00665.24 T023851_2 - 1.9e-13 50.5 0.0 3e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Trypsin PF00089.24 T338760_3 - 1.2e-08 34.9 0.0 2.1e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 T338760_3 - 0.0037 17.5 0.0 0.0077 16.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Transposase_1 PF01359.16 T238557_1 - 1.6e-23 82.2 1.0 2.9e-23 81.4 1.0 1.4 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T238557_3 - 3.1e-05 23.6 0.2 6e-05 22.7 0.2 1.3 1 0 0 1 1 1 1 Transposase (partial DDE domain) DUF1725 PF08333.9 T132185_3 - 0.12 12.0 0.8 0.21 11.1 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) TLV_coat PF00429.17 T168003_1 - 5e-21 74.9 0.2 8.3e-21 74.1 0.2 1.3 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) rve PF00665.24 T168003_1 - 6.3e-10 39.2 0.0 1.1e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.21 T168003_1 - 0.0013 18.6 0.2 0.0038 17.1 0.2 1.9 1 0 0 1 1 1 1 Zinc knuckle Gag_MA PF01140.17 T168003_1 - 0.013 15.1 0.0 0.013 15.1 0.0 2.1 2 0 0 2 2 2 0 Matrix protein (MA), p15 DUF3704 PF12488.6 T168003_1 - 0.56 9.8 5.5 1.4 8.5 5.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) Gag_p30 PF02093.14 T168003_2 - 3e-14 52.9 0.0 4.8e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RNase_H PF00075.22 T168003_2 - 1.5e-13 51.0 0.0 2.5e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 RNase H RVP PF00077.18 T168003_2 - 0.016 15.3 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF1725 PF08333.9 T026987_1 - 1.2e-08 34.3 0.4 2.4e-08 33.3 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1725 PF08333.9 T026987_2 - 7.2e-07 28.6 0.7 1.3e-06 27.7 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_1 PF01359.16 T091536_1 - 1.4e-14 53.5 0.0 3.4e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T091536_2 - 0.0056 16.4 0.4 0.014 15.1 0.4 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) ADK PF00406.20 T167024_2 - 2.1e-05 24.6 0.0 3.3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase DUF1720 PF08226.9 T099952_3 - 0.097 13.0 16.6 0.19 12.0 2.9 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF1720) DUF382 PF04037.11 T099952_3 - 5.1 7.1 7.0 56 3.8 0.0 4.4 4 1 1 5 5 5 0 Domain of unknown function (DUF382) DUF4705 PF15788.3 T324535_2 - 3.6e-21 75.0 69.8 9.8e-17 60.8 7.7 12.0 9 4 2 11 11 11 6 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324535_3 - 2.3e-14 53.2 98.3 0.0012 18.8 2.6 12.2 8 4 3 11 11 11 9 Domain of unknown function (DUF4705) DUF883 PF05957.11 T229995_1 - 0.095 13.2 5.3 0.16 12.4 5.3 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) IncA PF04156.12 T229995_1 - 1.7 8.2 10.7 2.8 7.5 10.7 1.2 1 0 0 1 1 1 0 IncA protein Jnk-SapK_ap_N PF09744.7 T229995_1 - 5 7.2 14.9 7.2 6.7 14.9 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 OmpH PF03938.12 T229995_1 - 5.7 6.8 11.3 8.2 6.3 11.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ADIP PF11559.6 T229995_1 - 9.1 6.2 11.9 13 5.7 11.9 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TMEM191C PF15194.4 T229995_3 - 5.8e-48 161.9 4.8 1e-47 161.0 4.8 1.3 1 0 0 1 1 1 1 TMEM191C family RVT_1 PF00078.25 T372727_1 - 5.1e-15 55.5 0.0 7.8e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T372727_1 - 5.6e-06 26.4 0.1 0.028 14.5 0.0 2.5 2 0 0 2 2 2 2 Integrase core domain zf-CCHC PF00098.21 T372727_1 - 0.0004 20.2 7.1 0.00044 20.1 1.5 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T372727_1 - 0.0041 16.7 12.1 0.08 12.5 2.3 2.7 2 0 0 2 2 2 2 GAG-polyprotein viral zinc-finger TLV_coat PF00429.17 T372727_3 - 1.8e-14 53.2 1.1 2.3e-14 52.9 1.1 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Rrn6 PF10214.7 T218395_1 - 0.00031 19.2 8.2 0.00043 18.7 8.2 1.2 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor DUF3682 PF12446.6 T218395_1 - 2.2 8.7 4.7 4.8 7.5 4.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) MIP-T3 PF10243.7 T218395_1 - 2.3 6.7 20.9 3 6.3 20.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CDC45 PF02724.12 T218395_1 - 2.6 6.1 18.2 3.5 5.7 18.2 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.11 T218395_2 - 0.17 10.5 6.0 0.23 10.1 6.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.15 T218395_2 - 0.97 8.0 5.0 1.4 7.5 5.0 1.2 1 0 0 1 1 1 0 Presenilin Eapp_C PF10238.7 T218395_2 - 1.4 8.9 4.3 2 8.3 4.3 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Nop14 PF04147.10 T218395_2 - 2.4 6.2 19.8 3.1 5.8 19.8 1.0 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.4 T218395_2 - 6.3 7.2 20.6 11 6.4 20.6 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FYDLN_acid PF09538.8 T218395_2 - 7.6 7.1 15.9 13 6.4 15.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) CDC45 PF02724.12 T218395_3 - 0.085 11.0 14.3 0.11 10.7 14.3 1.0 1 0 0 1 1 1 0 CDC45-like protein eIF3_subunit PF08597.8 T218395_3 - 0.66 9.7 30.3 0.95 9.2 30.3 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit PcfK PF14058.4 T218395_3 - 1 9.5 24.7 1.6 8.9 24.7 1.2 1 0 0 1 1 1 0 PcfK-like protein Eapp_C PF10238.7 T218395_3 - 1.9 8.4 11.1 2.9 7.8 11.1 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein SpoIIP PF07454.9 T218395_3 - 2 7.7 12.3 2.8 7.2 12.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FLO_LFY PF01698.14 T218395_3 - 4.5 6.2 23.6 6.9 5.6 23.6 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein YL1 PF05764.11 T218395_3 - 4.8 7.1 33.5 7 6.6 33.5 1.1 1 0 0 1 1 1 0 YL1 nuclear protein RNA_pol_Rpc4 PF05132.12 T218395_3 - 9.9 6.5 15.5 17 5.7 15.5 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Transposase_22 PF02994.12 T352327_1 - 6e-119 397.0 17.2 3.1e-118 394.7 17.1 1.8 1 1 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T352327_2 - 1.8e-16 59.9 4.8 2.4e-16 59.5 4.8 1.1 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T352327_2 - 6.4e-06 26.3 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T352327_2 - 7.4e-06 25.7 1.4 1.3e-05 24.9 1.4 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ISK_Channel PF02060.13 T352327_2 - 0.2 11.3 2.3 0.36 10.4 2.3 1.4 1 0 0 1 1 1 0 Slow voltage-gated potassium channel RWD PF05773.20 T258635_2 - 0.088 13.0 0.2 7.1 6.8 0.0 2.8 2 0 0 2 2 2 0 RWD domain Trypan_PARP PF05887.9 T258776_2 - 1.3 8.9 9.0 2.1 8.2 9.0 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Opiods_neuropep PF01160.16 T258776_3 - 0.047 13.6 2.5 8 6.5 0.1 3.2 2 1 1 3 3 3 0 Vertebrate endogenous opioids neuropeptide DUF812 PF05667.9 T012273_2 - 0.63 8.7 10.5 0.82 8.4 10.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) TLV_coat PF00429.17 T036538_1 - 9.8e-40 136.6 0.3 1.6e-39 135.9 0.3 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RNase_H PF00075.22 T036538_1 - 7e-10 39.1 0.1 1.7e-05 24.9 0.0 2.4 2 0 0 2 2 2 2 RNase H MIP-T3 PF10243.7 T036538_1 - 1.5 7.3 41.6 2.5 6.6 41.6 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Gag_p30 PF02093.14 T036538_2 - 3.2e-21 75.7 0.1 5.7e-21 74.9 0.1 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T036538_2 - 7.3e-05 22.9 0.0 0.015 15.4 0.0 2.4 2 0 0 2 2 2 2 Retroviral aspartyl protease zf-CCHC PF00098.21 T036538_2 - 0.00084 19.2 0.9 0.0023 17.8 0.9 1.8 1 0 0 1 1 1 1 Zinc knuckle Gag_MA PF01140.17 T036538_2 - 0.0015 18.1 0.2 0.003 17.1 0.2 1.3 1 0 0 1 1 1 1 Matrix protein (MA), p15 zf-CCHC_4 PF14392.4 T036538_2 - 0.064 12.8 0.4 0.13 11.8 0.4 1.5 1 0 0 1 1 1 0 Zinc knuckle Transposase_22 PF02994.12 T377435_1 - 3.7e-122 407.6 22.1 4.9e-108 361.1 10.2 2.2 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T377435_3 - 2e-43 148.3 1.2 2e-43 148.3 1.2 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) YqzE PF14038.4 T047714_1 - 0.31 10.9 5.2 0.67 9.9 5.2 1.5 1 0 0 1 1 1 0 YqzE-like protein Rrn6 PF10214.7 T047714_1 - 0.35 9.1 2.5 0.45 8.7 2.5 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1725 PF08333.9 T089227_2 - 0.00014 21.3 0.3 0.00026 20.4 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) rve PF00665.24 T089227_3 - 5.1e-07 29.8 0.0 1.2e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.4 T089227_3 - 0.017 14.8 0.1 0.044 13.4 0.0 1.7 2 0 0 2 2 2 0 Integrase core domain Gag_p30 PF02093.14 T236810_1 - 9.8e-27 93.7 1.5 1.8e-25 89.6 0.1 2.2 2 0 0 2 2 2 1 Gag P30 core shell protein rve PF00665.24 T236810_1 - 2.6e-15 56.5 0.0 4.5e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T236810_1 - 4.6e-10 39.3 0.0 6.9e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T236810_2 - 8.9e-13 47.7 0.5 1.3e-12 47.1 0.5 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T236810_2 - 0.003 17.0 0.0 0.0046 16.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T236810_3 - 8.9e-09 35.5 0.1 1.7e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 RNase H Gag_MA PF01140.17 T236810_3 - 0.0015 18.0 0.0 0.0032 17.0 0.0 1.4 1 0 0 1 1 1 1 Matrix protein (MA), p15 Transposase_22 PF02994.12 T376021_1 - 1.4e-101 339.9 18.0 2.8e-101 338.9 18.0 1.4 1 0 0 1 1 1 1 L1 transposable element Syntaxin-6_N PF09177.9 T376021_1 - 0.0046 17.4 4.8 0.02 15.3 4.8 2.1 1 0 0 1 1 1 1 Syntaxin 6, N-terminal EzrA PF06160.10 T376021_1 - 0.0084 14.2 5.7 0.013 13.6 5.7 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA KLRAQ PF10205.7 T376021_1 - 0.0093 16.1 2.0 0.028 14.5 2.0 1.7 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein Tropomyosin_1 PF12718.5 T376021_1 - 0.012 15.6 5.7 0.024 14.6 5.7 1.5 1 0 0 1 1 1 0 Tropomyosin like ADIP PF11559.6 T376021_1 - 0.014 15.4 1.8 0.014 15.4 1.8 2.4 3 0 0 3 3 2 0 Afadin- and alpha -actinin-Binding DUF2730 PF10805.6 T376021_1 - 0.097 12.6 0.6 0.25 11.3 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Seryl_tRNA_N PF02403.20 T376021_1 - 0.11 12.6 3.2 0.31 11.2 3.2 1.8 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Cep57_MT_bd PF06657.11 T376021_1 - 0.11 12.8 1.9 0.31 11.4 1.9 1.7 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DUF1515 PF07439.9 T376021_1 - 0.26 11.2 1.1 14 5.6 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) TMPIT PF07851.11 T376021_1 - 4.6 6.3 6.5 0.21 10.7 1.1 1.4 2 0 0 2 2 2 0 TMPIT-like protein XhlA PF10779.7 T376021_1 - 6.8 6.8 8.0 5.4 7.1 1.0 2.6 2 0 0 2 2 2 0 Haemolysin XhlA FlaC_arch PF05377.9 T376021_1 - 8.7 6.7 6.1 44 4.4 0.1 2.7 1 1 0 2 2 2 0 Flagella accessory protein C (FlaC) TGF_beta PF00019.18 T041774_2 - 1.5e-07 32.1 0.0 2.6e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain rve PF00665.24 T018212_2 - 5.7e-13 49.0 0.0 1.1e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain POM121 PF15229.4 T361759_1 - 1.2e-14 54.5 2.0 2.9e-14 53.2 2.0 1.6 1 0 0 1 1 1 1 POM121 family RBP_receptor PF14752.4 T358367_3 - 3.8e-40 137.9 1.7 5.1e-40 137.5 1.7 1.1 1 0 0 1 1 1 1 Retinol binding protein receptor DUF4551 PF15087.4 T021199_3 - 6.4 5.3 5.8 8.4 5.0 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RVT_1 PF00078.25 T063227_2 - 1.6e-15 57.1 0.0 2.3e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T063227_2 - 0.0057 16.7 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Gag_p30 PF02093.14 T063227_2 - 0.0091 15.4 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RNase_H PF00075.22 T063227_3 - 7.1e-17 61.8 0.0 1.4e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-H2C2 PF09337.8 T063227_3 - 3.7e-07 30.2 0.6 1.1e-06 28.6 0.6 1.9 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger DDE_1 PF03184.17 T371837_2 - 7.1e-37 126.5 0.4 1.1e-36 125.9 0.4 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 T371837_3 - 0.019 14.9 0.1 0.047 13.6 0.1 1.7 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain CCDC144C PF14915.4 T018736_1 - 5.1e-61 206.3 57.3 5.2e-36 124.2 14.1 3.3 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018736_1 - 5.2e-09 36.3 0.1 5.2e-09 36.3 0.1 4.3 4 0 0 4 4 4 1 Domain of unknown function (DUF3496) Laminin_II PF06009.10 T018736_1 - 0.0088 15.9 1.1 0.0088 15.9 1.1 2.9 3 0 0 3 3 3 1 Laminin Domain II CCDC144C PF14915.4 T018736_2 - 8.4e-17 61.1 9.6 8.4e-17 61.1 9.6 1.5 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region RVT_1 PF00078.25 T189216_1 - 4.2e-44 150.6 1.4 5.9e-44 150.1 1.4 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Presenilin PF01080.15 T039749_1 - 4.5 5.8 21.4 9 4.8 21.4 1.5 1 0 0 1 1 1 0 Presenilin DUF912 PF06024.10 T275904_2 - 0.027 14.6 0.0 0.14 12.4 0.0 2.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1510 PF07423.9 T275904_2 - 0.032 13.5 0.0 0.032 13.5 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1510) LRRC37AB_C PF14914.4 T275904_2 - 0.047 13.5 0.2 0.1 12.4 0.2 1.5 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain ODV-E18 PF10717.7 T275904_2 - 0.25 11.1 5.6 0.51 10.1 5.6 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 SR-25 PF10500.7 T275904_3 - 3.5 7.1 12.4 5.3 6.5 12.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SelP_N PF04592.12 T275904_3 - 8.7 5.5 18.0 14 4.9 18.0 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1725 PF08333.9 T268278_1 - 7.8e-05 22.1 1.8 0.00016 21.1 1.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) OrfB_Zn_ribbon PF07282.9 T037861_1 - 0.096 12.5 1.2 0.14 11.9 1.2 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Gag_p30 PF02093.14 T159803_1 - 0.0064 15.9 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T159803_1 - 0.083 13.0 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC PF00098.21 T159803_3 - 1.7e-05 24.6 3.9 4.5e-05 23.2 3.9 1.8 1 0 0 1 1 1 1 Zinc knuckle RVT_1 PF00078.25 T159803_3 - 0.12 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-TFIIB PF13453.4 T258044_2 - 0.85 8.9 9.9 67 2.8 0.0 6.1 5 0 0 5 5 5 0 Transcription factor zinc-finger Trypsin PF00089.24 T124875_1 - 9.7e-25 87.5 0.1 1.7e-24 86.7 0.1 1.3 1 0 0 1 1 1 1 Trypsin GPS PF01825.19 T229041_2 - 0.0011 19.4 0.2 0.015 15.8 0.1 2.7 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif GAIN PF16489.3 T229041_3 - 0.00055 19.3 0.0 0.00093 18.5 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Ubiquitin_3 PF14836.4 T138230_1 - 0.31 10.8 1.2 14 5.5 1.2 3.0 1 1 0 1 1 1 0 Ubiquitin-like domain Transposase_1 PF01359.16 T351156_1 - 0.048 13.4 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_1 PF01359.16 T351156_2 - 1e-20 73.2 7.1 1.8e-20 72.4 4.2 2.4 2 0 0 2 2 2 1 Transposase (partial DDE domain) BEN PF10523.7 T351156_2 - 0.078 13.1 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 BEN domain RBP_receptor PF14752.4 T358360_2 - 9.8e-40 136.6 1.8 1.3e-39 136.2 1.8 1.1 1 0 0 1 1 1 1 Retinol binding protein receptor ICAM_N PF03921.12 T233456_1 - 0.01 15.4 0.3 0.015 14.8 0.3 1.2 1 0 0 1 1 1 1 Intercellular adhesion molecule (ICAM), N-terminal domain PRP38_assoc PF12871.5 T132849_1 - 2.5 8.6 16.4 4.7 7.7 16.4 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Peptidase_S49_N PF08496.8 T188413_3 - 5 7.1 5.6 8.3 6.4 5.6 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Gag_p30 PF02093.14 T053875_2 - 5.6e-38 130.5 0.0 8.3e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein zf-CCHC PF00098.21 T053875_2 - 2.7e-16 58.7 23.8 3.1e-06 26.9 3.8 3.8 3 0 0 3 3 3 3 Zinc knuckle Gag_MA PF01140.17 T053875_2 - 1.7e-06 27.6 0.2 4e-06 26.4 0.2 1.6 1 0 0 1 1 1 1 Matrix protein (MA), p15 zf-CCHC_3 PF13917.4 T053875_2 - 5.7e-05 22.9 14.2 0.045 13.6 0.8 3.9 1 1 2 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.4 T053875_2 - 0.00046 19.8 30.8 0.0033 17.1 3.6 4.9 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.4 T053875_2 - 0.0042 16.6 11.7 0.44 10.2 1.2 3.6 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_5 PF14787.4 T053875_2 - 0.097 12.3 31.2 0.025 14.1 2.2 4.1 4 0 0 4 4 4 0 GAG-polyprotein viral zinc-finger rve PF00665.24 T053875_3 - 3.4e-20 72.3 0.0 5.1e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.4 T053875_3 - 0.0014 18.2 0.0 0.0027 17.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Amdo_NSP PF12475.6 T196781_1 - 8.6e-14 51.2 0.0 1.6e+02 2.3 0.0 18.5 6 4 20 26 26 26 0 Amdovirus non-structural protein Transketolase_N PF00456.19 T196781_1 - 2.9e-05 23.0 19.6 2.6 6.8 0.0 9.5 2 2 11 15 15 15 7 Transketolase, thiamine diphosphate binding domain Fels1 PF05666.9 T196781_3 - 2.4e-07 30.1 56.9 3.8 7.1 0.1 23.8 27 0 0 27 27 27 1 Fels-1 Prophage Protein-like HCBP_related PF06594.9 T196781_3 - 0.00024 20.8 150.3 8.3 6.3 0.1 26.6 27 0 0 27 27 27 25 Haemolysin-type calcium binding protein related domain PNMA PF14893.4 T177666_1 - 6.2e-45 153.9 0.0 8.7e-45 153.4 0.0 1.1 1 0 0 1 1 1 1 PNMA Nop14 PF04147.10 T057650_1 - 3.3 5.7 14.2 5.1 5.0 14.2 1.1 1 0 0 1 1 1 0 Nop14-like family MIP-T3 PF10243.7 T057650_2 - 1.1 7.8 40.0 1.6 7.2 40.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1510 PF07423.9 T057650_2 - 1.5 8.1 24.1 2.4 7.4 24.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SRP-alpha_N PF04086.11 T057650_2 - 2.1 8.0 22.7 3.9 7.2 22.7 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TFIIF_alpha PF05793.10 T057650_2 - 4.5 5.6 31.2 6.9 5.0 31.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Tim54 PF11711.6 T057650_2 - 6 5.4 18.6 9.3 4.8 18.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Rib PF08428.8 T182780_1 - 0.026 14.3 7.0 74 3.3 0.1 5.1 1 1 4 5 5 5 0 Rib/alpha-like repeat Transposase_1 PF01359.16 T351103_1 - 0.04 13.7 0.1 0.083 12.6 0.1 1.4 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_1 PF01359.16 T351103_2 - 5.9e-21 74.0 7.5 1.6e-20 72.6 4.6 2.6 2 0 0 2 2 2 1 Transposase (partial DDE domain) DDE_3 PF13358.4 T351103_2 - 0.0031 17.1 0.4 0.0055 16.3 0.4 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BEN PF10523.7 T351103_2 - 0.057 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 BEN domain CENP-B_dimeris PF09026.8 T138037_2 - 0.66 10.3 4.1 1.1 9.6 4.1 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Transposase_22 PF02994.12 T266286_2 - 1e-94 317.3 20.5 4.1e-92 308.7 10.8 2.2 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T266286_2 - 6.1e-06 25.6 2.1 1.4e-05 24.4 2.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T266286_3 - 9.5e-20 70.9 0.2 1.7e-19 70.1 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1028 PF06267.10 T259012_3 - 5.6 6.6 6.6 10 5.7 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) Transposase_1 PF01359.16 T347703_2 - 2e-20 72.3 0.6 4.5e-20 71.2 0.6 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T347703_3 - 0.0079 15.9 0.2 0.019 14.7 0.2 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) TLV_coat PF00429.17 T238780_3 - 8.6e-09 34.5 1.6 3.6e-08 32.4 1.6 1.8 1 1 0 1 1 1 1 ENV polyprotein (coat polyprotein) Transposase_22 PF02994.12 T103696_2 - 2.2e-142 474.1 20.5 3e-142 473.7 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103696_2 - 0.031 14.4 0.0 0.058 13.5 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103696_2 - 0.062 13.0 10.5 0.11 12.1 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103696_2 - 0.063 13.6 2.8 0.11 12.8 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103696_2 - 0.36 11.3 5.0 0.71 10.3 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103696_2 - 0.44 9.7 12.3 0.76 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103696_2 - 1.3 9.1 11.3 0.015 15.3 2.1 2.3 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103696_2 - 3.4 7.8 7.6 5.8 7.1 6.8 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Transposase_22 PF02994.12 T344838_2 - 1.8e-123 411.9 15.8 1.8e-123 411.9 15.8 1.8 2 0 0 2 2 2 1 L1 transposable element RVT_1 PF00078.25 T344838_2 - 4.4e-38 130.9 1.5 7.7e-38 130.1 1.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T344838_2 - 0.00024 21.2 0.0 0.00053 20.1 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family KLRAQ PF10205.7 T344838_2 - 0.098 12.8 3.8 0.22 11.6 3.8 1.5 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Seryl_tRNA_N PF02403.20 T344838_2 - 0.23 11.6 2.5 0.42 10.7 2.5 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.9 T344838_2 - 1.5 9.3 5.4 0.76 10.2 2.5 2.0 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Transposase_22 PF02994.12 T344838_3 - 8e-19 67.6 4.7 1.2e-18 67.1 4.7 1.1 1 0 0 1 1 1 1 L1 transposable element rve PF00665.24 T319917_1 - 8.4e-10 38.8 0.0 2.4e-09 37.3 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain RVP PF00077.18 T319917_1 - 0.00021 21.4 0.0 0.00038 20.5 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.8 T319917_1 - 0.079 13.1 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger RNase_H PF00075.22 T319917_3 - 4.9e-08 33.1 0.0 7.5e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 RNase H dUTPase PF00692.17 T331175_3 - 8.5e-11 41.5 0.0 1.4e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 dUTPase rve PF00665.24 T331175_3 - 1.6e-05 24.9 0.0 2.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Ribosomal_S14 PF00253.19 T315766_3 - 6.1 6.6 8.4 10 5.8 0.9 2.9 2 0 0 2 2 2 0 Ribosomal protein S14p/S29e HMG_box PF00505.17 T260445_3 - 4.7e-10 39.6 0.0 8.2e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T260445_3 - 0.0022 18.4 0.0 0.0042 17.5 0.0 1.3 1 0 0 1 1 1 1 HMG-box domain Pentapeptide_4 PF13599.4 T144215_1 - 1e-10 41.4 0.0 0.022 14.7 0.0 6.0 4 1 0 4 4 4 3 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T144215_2 - 8e-11 41.8 0.0 0.13 12.2 0.0 7.1 4 3 4 8 8 8 3 Pentapeptide repeats (9 copies) Lamprin PF06403.9 T144215_2 - 0.0002 21.2 2.4 0.44 10.4 0.1 4.0 3 1 1 4 4 4 3 Lamprin Pentapeptide_4 PF13599.4 T144215_3 - 2.6e-15 56.2 0.0 0.17 11.9 0.0 7.1 4 3 2 6 6 6 5 Pentapeptide repeats (9 copies) Lamprin PF06403.9 T144215_3 - 0.099 12.5 0.0 17 5.2 0.0 3.2 3 0 0 3 3 3 0 Lamprin IQ PF00612.25 T272738_2 - 0.002 17.6 0.1 0.0062 16.1 0.1 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif Gag_p30 PF02093.14 T089132_1 - 3e-14 52.9 0.0 4.6e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T089132_1 - 4.6e-07 29.5 0.0 8.1e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T089132_1 - 8.8e-06 25.4 1.0 2.3e-05 24.1 1.0 1.8 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.18 T089132_1 - 0.00051 20.1 0.0 0.00094 19.3 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_5 PF14787.4 T089132_1 - 0.057 13.0 2.7 0.13 11.9 2.7 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger RNase_H PF00075.22 T089132_3 - 7.2e-15 55.3 0.1 1.1e-14 54.6 0.1 1.3 1 0 0 1 1 1 1 RNase H TLV_coat PF00429.17 T089132_3 - 2.7e-12 46.1 0.3 2.7e-12 46.1 0.3 1.9 2 0 0 2 2 2 1 ENV polyprotein (coat polyprotein) Transposase_22 PF02994.12 T258953_1 - 0.00063 18.6 0.0 0.001 17.9 0.0 1.2 1 0 0 1 1 1 1 L1 transposable element DUF678 PF05077.10 T258953_3 - 3.1 7.9 5.7 0.85 9.7 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF678) zf-RVT PF13966.4 T336882_1 - 0.63 10.8 6.0 37 5.1 0.0 4.6 5 0 0 5 5 5 0 zinc-binding in reverse transcriptase Ank_3 PF13606.4 T336882_2 - 0.065 13.7 0.6 1.1e+02 3.7 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat AMPKBI PF04739.13 T183084_2 - 0.027 14.6 2.2 28 4.9 0.0 3.3 3 0 0 3 3 3 0 5'-AMP-activated protein kinase beta subunit, interaction domain DUF3481 PF11980.6 T183084_3 - 0.08 12.5 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein GP41 PF00517.15 T202701_1 - 4e-10 39.8 0.3 6.8e-10 39.0 0.3 1.3 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_env_2 PF13804.4 T202701_2 - 3.6e-37 127.6 0.2 5.8e-37 126.9 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Transposase_1 PF01359.16 T351099_1 - 5.5e-21 74.1 7.5 1.5e-20 72.6 4.6 2.6 2 0 0 2 2 2 1 Transposase (partial DDE domain) DDE_3 PF13358.4 T351099_1 - 0.0027 17.3 0.4 0.0051 16.4 0.4 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BEN PF10523.7 T351099_1 - 0.06 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 BEN domain RCDG1 PF15725.3 T351099_1 - 8.7 6.7 15.4 3.1 8.2 4.1 2.6 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein Transposase_1 PF01359.16 T351099_3 - 0.08 12.7 0.1 0.08 12.7 0.1 1.8 2 0 0 2 2 2 0 Transposase (partial DDE domain) TOM6p PF15184.4 T376177_2 - 0.0085 15.7 0.0 0.17 11.5 0.0 2.3 1 1 1 2 2 2 1 Mitochondrial import receptor subunit TOM6 homolog Arylesterase PF01731.18 T381565_3 - 0.047 13.8 0.0 0.093 12.8 0.0 1.4 1 0 0 1 1 1 0 Arylesterase DUF1777 PF08648.10 T316531_1 - 1.2e-05 25.4 13.3 1.2e-05 25.4 13.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1777) CDC45 PF02724.12 T316531_1 - 2.4 6.2 10.6 3.6 5.7 10.6 1.1 1 0 0 1 1 1 0 CDC45-like protein PRP38_assoc PF12871.5 T316531_1 - 3.1 8.3 42.0 6.7 7.2 42.0 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Trypan_PARP PF05887.9 T316531_1 - 7.7 6.4 10.7 16 5.4 10.7 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF1777 PF08648.10 T316531_2 - 0.00012 22.2 19.1 0.00012 22.2 19.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1777) DUF1510 PF07423.9 T275909_1 - 0.034 13.4 0.0 0.034 13.4 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1510) DUF912 PF06024.10 T275909_1 - 0.034 14.3 0.0 0.14 12.4 0.0 2.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) LRRC37AB_C PF14914.4 T275909_1 - 0.047 13.4 0.2 0.1 12.4 0.2 1.5 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain ODV-E18 PF10717.7 T275909_1 - 0.25 11.1 5.6 0.51 10.1 5.6 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF3446 PF11928.6 T275909_2 - 0.078 13.2 11.5 0.19 11.9 11.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) SR-25 PF10500.7 T275909_2 - 3.2 7.2 12.4 5.2 6.5 12.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SelP_N PF04592.12 T275909_2 - 7.7 5.7 17.9 12 5.1 17.9 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF913 PF06025.10 T172397_1 - 0.0065 15.3 1.5 0.01 14.7 1.5 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) CPSF100_C PF13299.4 T172397_1 - 2.1 8.4 10.9 0.022 14.8 2.2 1.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RP-C_C PF11800.6 T172397_1 - 4.9 7.0 6.7 9.2 6.1 6.7 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region SpoIIP PF07454.9 T172397_1 - 5.2 6.3 14.4 1.9 7.8 11.2 1.7 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Gag_p30 PF02093.14 T089220_1 - 1.7e-20 73.3 0.1 2.6e-20 72.7 0.1 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_MA PF01140.17 T089220_1 - 1.2e-13 50.7 0.0 2.2e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Matrix protein (MA), p15 rve PF00665.24 T089220_1 - 8.7e-05 22.6 0.0 0.00017 21.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.4 T089220_1 - 0.057 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.25 T089220_2 - 7.8e-13 48.3 0.0 1.3e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T089220_2 - 0.0024 17.9 0.0 0.0044 17.1 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T089220_3 - 9.2e-11 41.5 5.1 2.5e-08 33.6 0.6 2.1 1 1 1 2 2 2 2 Gag P30 core shell protein RVP PF00077.18 T089220_3 - 1.1e-05 25.5 0.0 2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.4 T089220_3 - 0.13 12.8 0.1 0.23 12.1 0.1 1.3 1 0 0 1 1 1 0 Aspartyl protease Transposase_1 PF01359.16 T084402_1 - 3.3e-28 97.2 0.0 8.6e-28 95.9 0.0 1.7 1 0 0 1 1 1 1 Transposase (partial DDE domain) TAF8_C PF10406.7 T284132_1 - 0.068 13.6 0.1 0.17 12.3 0.1 1.6 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term Colipase-like PF15083.4 T090327_1 - 6.6e-14 51.7 5.0 1.6e-13 50.4 5.0 1.7 1 0 0 1 1 1 1 Colipase-like Colipase-like PF15083.4 T090327_2 - 1.6e-11 44.0 0.3 4e-11 42.8 0.3 1.7 1 0 0 1 1 1 1 Colipase-like Colipase-like PF15083.4 T090327_3 - 1.6e-10 40.8 3.6 4.6e-10 39.4 3.6 1.7 1 0 0 1 1 1 1 Colipase-like MIP-T3 PF10243.7 T090327_3 - 1.9 7.0 62.6 4.7 5.7 62.6 1.5 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1725 PF08333.9 T198724_1 - 0.0033 16.9 0.3 0.0057 16.1 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1117 PF06547.10 T227243_3 - 0.0028 18.1 1.6 0.0061 17.0 1.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1117) TLV_coat PF00429.17 T238785_3 - 8.4e-09 34.5 2.1 4e-08 32.3 2.1 1.9 1 1 0 1 1 1 1 ENV polyprotein (coat polyprotein) Toxin_18 PF08087.9 T234700_1 - 1.6 8.7 10.9 2 8.4 2.1 2.9 2 0 0 2 2 2 0 Conotoxin O-superfamily PhoPQ_related PF10142.7 T155650_1 - 9.3e-18 63.9 0.0 1.2e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein TonB_N PF16031.3 T181584_1 - 0.00019 21.8 19.9 0.00019 21.8 19.9 1.8 2 0 0 2 2 2 1 TonB N-terminal region Trypan_PARP PF05887.9 T181584_1 - 0.17 11.7 13.1 0.38 10.6 13.1 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Corona_nucleoca PF00937.16 T181584_2 - 0.17 10.8 18.1 0.25 10.2 18.1 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Transformer PF06495.9 T181584_2 - 3.9 7.4 25.7 7.8 6.4 25.7 1.4 1 0 0 1 1 1 0 Fruit fly transformer protein Trypan_PARP PF05887.9 T181584_3 - 0.0031 17.4 15.0 0.0051 16.7 15.0 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Tim54 PF11711.6 T181584_3 - 1 7.9 5.6 1.4 7.5 5.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 IQ PF00612.25 T272754_2 - 0.00067 19.1 1.2 0.0045 16.5 0.1 2.8 2 0 0 2 2 2 1 IQ calmodulin-binding motif Lbh PF15317.4 T110890_1 - 2.9e-08 34.3 0.3 5.7e-08 33.4 0.3 1.4 1 0 0 1 1 1 1 Cardiac transcription factor regulator, Developmental protein Transposase_22 PF02994.12 T276918_1 - 1.5e-35 122.6 15.7 2.6e-33 115.2 3.7 3.1 2 1 0 3 3 3 2 L1 transposable element DUF1725 PF08333.9 T276918_1 - 3.5e-10 39.1 10.2 1.7e-07 30.6 0.7 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T276918_3 - 0.0036 16.7 1.0 0.31 10.4 0.2 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Arylesterase PF01731.18 T381525_3 - 0.068 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Arylesterase MSG PF02349.13 T315664_3 - 0.27 11.3 5.9 22 5.2 0.4 3.3 1 1 1 2 2 2 0 Major surface glycoprotein RVT_1 PF00078.25 T344413_1 - 7.3e-32 110.5 0.3 1.2e-31 109.8 0.3 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T344413_2 - 2.5e-34 118.6 13.4 2.2e-33 115.5 4.7 2.4 2 0 0 2 2 2 2 L1 transposable element Transposase_22 PF02994.12 T344413_3 - 6.9e-33 113.9 0.3 1.2e-32 113.0 0.3 1.4 1 0 0 1 1 1 1 L1 transposable element TLV_coat PF00429.17 T168002_2 - 1.8e-25 89.5 1.0 3.2e-25 88.7 1.0 1.3 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) rve PF00665.24 T168002_2 - 6e-10 39.2 0.0 1.1e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.21 T168002_2 - 0.0013 18.6 0.2 0.0038 17.1 0.2 1.9 1 0 0 1 1 1 1 Zinc knuckle Gag_MA PF01140.17 T168002_2 - 0.013 15.1 0.0 0.013 15.1 0.0 2.0 2 0 0 2 2 2 0 Matrix protein (MA), p15 DUF3704 PF12488.6 T168002_2 - 0.55 9.8 5.5 1.4 8.5 5.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) Gag_p30 PF02093.14 T168002_3 - 2.9e-14 52.9 0.0 4.7e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RNase_H PF00075.22 T168002_3 - 1.5e-13 51.0 0.0 2.4e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 RNase H RVP PF00077.18 T168002_3 - 0.016 15.4 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF4705 PF15788.3 T322058_1 - 5.5e-27 93.6 223.5 2e-14 53.4 12.6 20.0 6 4 10 17 17 17 8 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322058_2 - 3.3e-48 161.5 247.2 2.6e-18 65.8 10.8 20.9 11 5 7 19 19 19 15 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322058_3 - 7.1e-08 32.4 213.4 0.0031 17.5 6.0 20.1 14 4 3 17 17 17 10 Domain of unknown function (DUF4705) DUF1725 PF08333.9 T364415_1 - 0.006 16.1 0.6 0.014 14.9 0.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RnaseA PF00074.18 T100533_2 - 4e-05 24.0 2.9 4e-05 24.0 2.9 1.6 2 0 0 2 2 2 1 Pancreatic ribonuclease RnaseA PF00074.18 T100533_3 - 0.00014 22.3 0.0 0.00028 21.3 0.0 1.5 1 0 0 1 1 1 1 Pancreatic ribonuclease DUF4575 PF15143.4 T335616_1 - 2.6e-74 247.5 87.4 1e-13 51.5 5.5 10.8 6 2 4 10 10 10 10 Domain of unknown function (DUF4575) DUF4575 PF15143.4 T335616_2 - 5.5e-70 233.5 88.8 1.1e-20 74.0 10.3 9.5 6 3 3 9 9 9 9 Domain of unknown function (DUF4575) DUF4575 PF15143.4 T335616_3 - 2.4e-75 250.8 96.6 8.7e-17 61.4 10.1 11.3 7 2 4 11 11 11 11 Domain of unknown function (DUF4575) RVT_1 PF00078.25 T274832_1 - 7.6e-25 87.6 0.3 2.8e-13 49.8 0.1 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.12 T274832_1 - 1.4e-24 85.5 0.6 3.5e-24 84.2 0.6 1.7 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVP PF00077.18 T274832_1 - 1.7e-20 73.0 0.0 3.7e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T274832_1 - 1.8e-18 66.7 0.0 3.4e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Gag_p10 PF02337.15 T274832_1 - 4.2e-14 52.0 0.2 9.1e-14 50.9 0.2 1.6 1 0 0 1 1 1 1 Retroviral GAG p10 protein Gag_p24 PF00607.18 T274832_1 - 1.9e-12 47.4 0.2 4e-12 46.3 0.2 1.5 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) GP41 PF00517.15 T274832_1 - 2.2e-12 47.1 0.5 4.3e-12 46.2 0.5 1.4 1 0 0 1 1 1 1 Retroviral envelope protein RNase_H PF00075.22 T274832_1 - 7e-11 42.4 0.1 7e-11 42.4 0.1 1.7 2 0 0 2 2 1 1 RNase H G-patch PF01585.21 T274832_1 - 8.3e-09 35.1 2.2 1.8e-08 34.0 2.2 1.5 1 0 0 1 1 1 1 G-patch domain Integrase_Zn PF02022.17 T274832_1 - 0.00065 19.5 1.5 0.0024 17.7 1.5 2.1 1 0 0 1 1 1 1 Integrase Zinc binding domain IN_DBD_C PF00552.19 T274832_1 - 0.0022 17.1 3.1 0.0051 15.9 3.1 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain gag-asp_proteas PF13975.4 T274832_1 - 0.16 12.4 0.0 0.35 11.3 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Gag_p24 PF00607.18 T274832_2 - 8.5e-27 94.2 0.0 1.2e-26 93.7 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) dUTPase PF00692.17 T274832_2 - 9.7e-20 70.4 0.0 3.1e-18 65.6 0.0 2.2 2 0 0 2 2 2 1 dUTPase RVT_1 PF00078.25 T274832_2 - 7e-05 22.3 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_5 PF14787.4 T274832_3 - 1.6e-06 27.6 19.3 4.9e-06 26.0 8.8 3.2 2 1 0 2 2 2 2 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.21 T274832_3 - 0.00051 19.9 6.8 0.0037 17.1 6.2 3.0 2 0 0 2 2 2 1 Zinc knuckle RNase_H PF00075.22 T274832_3 - 0.038 14.0 0.0 0.062 13.4 0.0 1.3 1 0 0 1 1 1 0 RNase H TLV_coat PF00429.17 T290883_2 - 0.00025 19.7 3.2 0.0024 16.5 0.0 2.7 3 0 0 3 3 3 2 ENV polyprotein (coat polyprotein) Lamprin PF06403.9 T221916_1 - 0.16 11.8 12.1 0.16 11.8 0.6 2.5 1 1 1 2 2 2 0 Lamprin Lamprin PF06403.9 T221916_3 - 0.015 15.1 8.9 0.036 13.9 8.9 1.6 1 0 0 1 1 1 0 Lamprin RVT_1 PF00078.25 T379586_1 - 1.3e-34 119.6 1.8 2.1e-34 118.9 1.8 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T379586_1 - 0.016 14.6 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein RVP PF00077.18 T379586_2 - 1.5e-06 28.2 0.0 2.8e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T379586_2 - 0.012 15.7 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain zf-CCHC PF00098.21 T379586_3 - 1.3 9.1 11.9 0.54 10.3 6.3 2.7 2 0 0 2 2 2 0 Zinc knuckle PLA2_inh PF02988.13 T035079_2 - 0.086 13.4 4.3 0.19 12.3 4.3 1.6 1 0 0 1 1 1 0 Phospholipase A2 inhibitor UPAR_LY6 PF00021.19 T035079_2 - 0.19 12.3 5.3 0.36 11.4 5.3 1.5 1 0 0 1 1 1 0 u-PAR/Ly-6 domain DUF3060 PF11259.6 T051125_1 - 1.1e-05 24.9 0.0 5 6.8 0.0 4.2 2 1 1 4 4 4 4 Protein of unknown function (DUF3060) DUF296 PF03479.13 T051125_1 - 0.15 12.4 6.4 7.4e+02 0.6 6.4 4.0 1 1 0 1 1 1 0 Domain of unknown function (DUF296) Transposase_1 PF01359.16 T349338_1 - 1.1e-18 66.8 0.1 1.9e-18 66.0 0.1 1.4 1 0 0 1 1 1 1 Transposase (partial DDE domain) MRP-L28 PF09812.7 T369081_2 - 1.7 8.6 5.5 3.5 7.6 5.5 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 Gly-zipper_YMGG PF13441.4 T173646_3 - 0.08 12.6 1.5 0.16 11.6 1.5 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper CAP_N PF01213.17 T059797_2 - 6.2 6.1 11.5 13 5.0 11.5 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Transposase_1 PF01359.16 T082366_1 - 1.5e-19 69.5 0.1 5e-19 67.8 0.0 1.9 2 0 0 2 2 2 1 Transposase (partial DDE domain) Transposase_22 PF02994.12 T103742_1 - 2.1e-142 474.2 20.5 2.9e-142 473.8 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103742_1 - 0.03 14.4 0.0 0.057 13.6 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103742_1 - 0.06 13.0 10.5 0.11 12.1 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103742_1 - 0.061 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103742_1 - 0.34 11.3 5.0 0.69 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103742_1 - 0.43 9.8 12.3 0.74 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103742_1 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103742_1 - 3 8.0 7.5 5.3 7.2 6.7 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Ribosomal_L39 PF00832.18 T003462_3 - 0.018 14.5 0.6 0.067 12.7 0.6 1.9 1 0 0 1 1 1 0 Ribosomal L39 protein Transposase_22 PF02994.12 T103734_3 - 2.1e-142 474.2 20.5 2.9e-142 473.7 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103734_3 - 0.03 14.4 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103734_3 - 0.06 13.0 10.5 0.11 12.1 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103734_3 - 0.061 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103734_3 - 0.35 11.3 5.0 0.7 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103734_3 - 0.43 9.8 12.3 0.75 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103734_3 - 1.2 9.1 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103734_3 - 3.1 8.0 7.5 5.3 7.2 6.7 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein RVT_1 PF00078.25 T097870_1 - 8.4e-13 48.2 0.1 1.5e-12 47.4 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.4 T097870_1 - 0.00016 21.4 0.7 0.0003 20.5 0.7 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Transposase_22 PF02994.12 T097870_2 - 1.6e-56 191.6 27.9 1.4e-51 175.3 22.9 2.9 2 1 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T097870_2 - 3e-06 26.6 1.1 7.1e-06 25.4 1.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos PF03372.21 T097870_2 - 0.044 13.9 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family HSBP1 PF06825.10 T097870_2 - 0.22 11.3 4.5 5.8 6.8 0.5 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Syntaxin-6_N PF09177.9 T097870_2 - 0.27 11.7 4.7 0.76 10.2 4.7 1.8 1 0 0 1 1 1 0 Syntaxin 6, N-terminal IncA PF04156.12 T097870_2 - 8 6.1 12.0 2 8.0 5.5 2.3 2 0 0 2 2 2 0 IncA protein Transposase_22 PF02994.12 T097870_3 - 8e-25 87.3 0.0 1.4e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T097870_3 - 2.3e-15 56.6 0.5 3.7e-15 55.9 0.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Yae1_N PF09811.7 T207322_3 - 2.3 7.9 12.7 0.16 11.6 7.8 1.6 2 0 0 2 2 2 0 Essential protein Yae1, N terminal rve PF00665.24 T236798_1 - 4.8e-09 36.3 0.0 8.3e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T236798_1 - 0.0024 17.3 0.0 0.0039 16.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_MA PF01140.17 T236798_2 - 0.0014 18.2 0.0 0.0027 17.3 0.0 1.4 1 0 0 1 1 1 1 Matrix protein (MA), p15 Gag_p30 PF02093.14 T236798_3 - 6.8e-27 94.2 1.5 1.5e-25 89.8 0.1 2.2 2 0 0 2 2 2 1 Gag P30 core shell protein Transposase_22 PF02994.12 T236798_3 - 7.3e-13 48.0 0.5 1.1e-12 47.3 0.5 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T236798_3 - 5.9e-07 29.1 0.0 9.3e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4705 PF15788.3 T051863_1 - 3.1e-49 164.8 256.2 1.3e-06 28.3 9.0 24.6 11 7 11 22 22 22 17 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T051863_2 - 8.3e-43 144.2 254.5 4.4e-14 52.3 8.5 26.3 13 7 9 22 22 22 16 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T051863_3 - 2.8e-32 110.5 231.3 4.7e-12 45.8 5.6 23.8 16 7 9 25 25 25 16 Domain of unknown function (DUF4705) Transposase_1 PF01359.16 T014934_1 - 1.3e-06 28.0 0.0 1.3e-06 28.0 0.0 1.9 2 0 0 2 2 2 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T014934_2 - 1.2e-23 82.7 0.4 1.2e-23 82.7 0.4 2.0 2 0 0 2 2 2 1 Transposase (partial DDE domain) RVT_1 PF00078.25 T039848_2 - 9.4e-18 64.4 0.0 2.5e-17 63.0 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Colipase-like PF15083.4 T051477_2 - 1.7e-08 34.3 64.4 0.0017 18.3 12.7 4.2 2 1 1 4 4 4 3 Colipase-like Mucin-like PF16058.3 T051477_2 - 2.1e-07 30.8 18.0 0.01 15.7 0.0 5.8 4 1 2 6 6 6 3 Mucin-like DDE_1 PF03184.17 T098223_1 - 1.6e-17 63.5 0.0 3e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease RBP_receptor PF14752.4 T358361_2 - 2.5e-24 85.7 0.0 4.3e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Retinol binding protein receptor Raffinose_syn PF05691.10 T276652_2 - 0.042 11.5 0.4 5.9 4.4 0.0 3.4 3 1 0 4 4 4 0 Raffinose synthase or seed imbibition protein Sip1 DUF759 PF05537.9 T276652_3 - 0.006 15.4 0.1 8.8 5.0 0.0 4.1 5 0 0 5 5 5 2 Borrelia burgdorferi protein of unknown function (DUF759) Raffinose_syn PF05691.10 T276652_3 - 0.054 11.1 0.2 2 6.0 0.0 3.3 5 0 0 5 5 5 0 Raffinose synthase or seed imbibition protein Sip1 Lamprin PF06403.9 T221919_2 - 0.014 15.3 8.9 0.031 14.1 8.9 1.6 1 0 0 1 1 1 0 Lamprin Lamprin PF06403.9 T221919_3 - 0.12 12.2 12.1 0.14 12.0 0.6 2.6 1 1 1 2 2 2 0 Lamprin RVT_1 PF00078.25 T337385_1 - 1.3e-09 37.7 0.0 2.1e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T337385_2 - 3.8e-37 127.8 0.8 3.8e-37 127.8 0.8 2.0 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T337385_3 - 0.00014 21.3 0.0 0.00026 20.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RNase_H PF00075.22 T172327_2 - 1.3e-16 61.0 0.0 2.1e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-H2C2 PF09337.8 T172327_2 - 4.9e-05 23.4 0.3 0.0001 22.4 0.3 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger 7tm_4 PF13853.4 T112618_1 - 2.3e-17 63.5 7.9 3.3e-17 63.0 7.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T112618_1 - 4.1e-09 35.9 1.5 6.5e-09 35.3 1.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CCDC144C PF14915.4 T018829_1 - 6.3e-29 100.9 16.4 6.3e-29 100.9 16.4 2.5 3 0 0 3 3 3 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018829_1 - 1.5e-15 57.4 6.5 1.5e-15 57.4 6.5 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3496) CCDC144C PF14915.4 T018829_2 - 2.7e-29 102.1 13.6 2.7e-29 102.1 13.6 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018829_2 - 3.1 7.7 19.2 0.025 14.5 1.1 2.5 2 0 0 2 2 2 0 Laminin Domain II BAR_3_WASP_bdg PF10456.7 T018829_3 - 1.3e-08 34.5 0.4 1.9e-08 34.0 0.4 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein CCDC144C PF14915.4 T018829_3 - 6.4e-07 28.7 3.0 8.7e-07 28.2 3.0 1.2 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region IncA PF04156.12 T170374_2 - 0.12 12.0 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 IncA protein Presenilin PF01080.15 T108364_1 - 0.0044 15.7 8.8 0.0069 15.0 8.8 1.2 1 0 0 1 1 1 1 Presenilin NOA36 PF06524.10 T108364_1 - 1.3 8.2 16.2 2.4 7.3 16.2 1.3 1 0 0 1 1 1 0 NOA36 protein RNA_pol_3_Rpc31 PF11705.6 T108364_1 - 3 7.9 31.3 0.27 11.3 26.1 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 FYDLN_acid PF09538.8 T108364_1 - 3.5 8.2 18.1 6.9 7.3 18.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) PPP4R2 PF09184.9 T108364_1 - 3.6 7.0 20.2 6.5 6.1 20.2 1.3 1 0 0 1 1 1 0 PPP4R2 RNA_pol_Rpc4 PF05132.12 T108364_1 - 5.2 7.4 9.2 0.054 13.8 1.7 1.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 RXT2_N PF08595.9 T108364_1 - 7.3 6.5 18.4 13 5.7 18.4 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal ETRAMP PF09716.8 T108364_2 - 0.12 12.4 0.0 0.12 12.4 0.0 2.0 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) MIP-T3 PF10243.7 T108364_2 - 6.5 5.2 17.9 9.3 4.7 17.9 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF913 PF06025.10 T108364_3 - 2.3 7.0 5.1 3.5 6.4 5.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) API5 PF05918.9 T108364_3 - 9.5 4.8 14.0 13 4.3 14.0 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Filament PF00038.19 T078924_1 - 2.9e-40 138.7 14.0 3.8e-40 138.3 14.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein CALCOCO1 PF07888.9 T078924_1 - 0.9 7.9 11.7 1.2 7.5 11.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.9 T078924_1 - 0.93 8.2 9.9 1.6 7.4 9.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein BRE1 PF08647.9 T078924_1 - 1.2 9.1 10.2 1.3 9.0 3.0 2.3 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Tropomyosin_1 PF12718.5 T078924_1 - 6.3 6.8 12.9 10 6.1 12.9 1.2 1 0 0 1 1 1 0 Tropomyosin like Muted PF14942.4 T078924_1 - 10 6.3 10.5 16 5.7 10.5 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Filament PF00038.19 T078924_2 - 0.0051 16.3 0.0 0.0065 16.0 0.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein Gag_MA PF01140.17 T373077_1 - 0.0039 16.7 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 Matrix protein (MA), p15 Gag_p30 PF02093.14 T373077_3 - 3.4e-12 46.2 0.0 5e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Gag P30 core shell protein zf-CCHC PF00098.21 T373077_3 - 5.2e-07 29.3 7.7 2.6e-06 27.1 2.4 2.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_2 PF13696.4 T373077_3 - 0.0097 15.6 6.5 0.055 13.1 2.2 2.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T373077_3 - 0.013 15.1 2.6 0.013 15.1 2.6 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.4 T373077_3 - 0.035 13.9 0.9 0.081 12.8 0.9 1.6 1 0 0 1 1 1 0 Zinc knuckle eIF3g PF12353.6 T373077_3 - 1.8 8.8 9.2 9.4 6.5 3.0 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G Transposase_22 PF02994.12 T165141_3 - 2.3e-07 29.9 0.7 3.9e-07 29.1 0.7 1.3 1 0 0 1 1 1 1 L1 transposable element DUF2981 PF11200.6 T165141_3 - 3.9 6.5 10.1 24 3.8 3.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2981) Filament PF00038.19 T078932_2 - 2.8e-40 138.7 14.0 3.6e-40 138.3 14.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein CALCOCO1 PF07888.9 T078932_2 - 0.86 8.0 11.7 1.2 7.5 11.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.9 T078932_2 - 0.9 8.2 9.9 1.5 7.5 9.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein BRE1 PF08647.9 T078932_2 - 1.3 9.0 10.2 1.2 9.1 3.0 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Tropomyosin_1 PF12718.5 T078932_2 - 6.3 6.8 12.9 9.7 6.2 12.9 1.1 1 0 0 1 1 1 0 Tropomyosin like GAIN PF16489.3 T229062_1 - 9.8e-35 119.7 0.0 1.4e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain DUF3809 PF12723.5 T182961_3 - 0.027 14.6 0.2 3.2e+02 1.4 0.0 5.7 3 3 5 8 8 8 0 Protein of unknown function (DUF3809) RVT_1 PF00078.25 T039850_2 - 9.1e-21 74.3 0.0 1.8e-20 73.3 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T039850_3 - 2.4e-20 73.1 0.0 4.7e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 RNase H zf-H2C2 PF09337.8 T039850_3 - 7.2e-07 29.3 0.4 1.5e-06 28.2 0.4 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Transposase_22 PF02994.12 T353739_1 - 1.2e-29 103.2 3.3 1.1e-14 53.9 0.4 2.2 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T353739_3 - 7.1e-09 34.9 1.5 7e-08 31.8 0.7 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) DUF2054 PF10218.7 T353739_3 - 4.8e-05 23.3 9.1 0.00014 21.8 9.1 1.8 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2054) RVT_1 PF00078.25 T353739_3 - 0.001 18.5 0.0 0.0018 17.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SSP160 PF06933.9 T238526_1 - 0.12 10.4 9.5 0.17 10.0 9.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.6 T238526_1 - 8.8 6.2 16.0 18 5.1 16.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Suf PF05843.12 T238526_2 - 0.015 15.2 2.2 0.022 14.6 2.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SUIM_assoc PF16619.3 T238526_2 - 0.064 13.2 6.9 0.12 12.3 6.9 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CCDC117 PF15810.3 T238526_2 - 0.19 11.9 3.2 2.5 8.3 1.3 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 117 DUF2722 PF10846.6 T238526_2 - 0.92 8.2 6.7 1.3 7.8 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Androgen_recep PF02166.14 T238526_2 - 1 8.0 6.0 1.5 7.5 6.0 1.1 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.6 T238526_2 - 1.2 8.5 11.0 2.2 7.7 11.0 1.3 1 0 0 1 1 1 0 Spt20 family GATase_7 PF13537.4 T222967_2 - 1.1e-16 60.7 0.0 1.8e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.4 T222967_2 - 1.6e-11 44.4 0.0 2.7e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.6 T222967_2 - 0.052 12.8 0.0 0.08 12.2 0.0 1.2 1 0 0 1 1 1 0 Aluminium induced protein Ig_3 PF13927.4 T183413_2 - 0.059 13.9 1.2 15 6.2 0.0 4.3 4 2 1 5 5 5 0 Immunoglobulin domain DUF1724 PF08350.8 T183413_3 - 0.084 12.9 0.0 7.1 6.7 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1724) ssDNA-exonuc_C PF10141.7 T050205_2 - 0.14 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain MNE1 PF13762.4 T050205_2 - 0.22 11.4 2.5 0.38 10.7 2.5 1.3 1 0 0 1 1 1 0 Mitochondrial splicing apparatus component Mucin-like PF16058.3 T300736_2 - 0.0039 17.1 4.3 0.011 15.6 4.4 1.8 1 1 0 1 1 1 1 Mucin-like Herpes_LMP1 PF05297.9 T300736_2 - 4.1 6.3 8.0 6.5 5.7 8.0 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Epiglycanin_C PF14654.4 T300736_3 - 3e-09 36.7 0.7 6e-09 35.8 0.7 1.5 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300736_3 - 1.7e-06 27.9 4.4 4e-06 26.7 4.4 1.6 1 0 0 1 1 1 1 Mucin-like BAGE PF08180.9 T159427_2 - 4.3e-07 29.8 1.1 8.3e-07 28.9 1.1 1.5 1 0 0 1 1 1 1 B melanoma antigen family CDC45 PF02724.12 T218394_1 - 0.07 11.3 14.3 0.086 11.0 14.3 1.0 1 0 0 1 1 1 0 CDC45-like protein eIF3_subunit PF08597.8 T218394_1 - 0.57 9.9 30.3 0.79 9.5 30.3 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit PcfK PF14058.4 T218394_1 - 0.89 9.7 24.7 1.3 9.2 24.7 1.2 1 0 0 1 1 1 0 PcfK-like protein Eapp_C PF10238.7 T218394_1 - 1.7 8.6 11.1 2.5 8.1 11.1 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein SpoIIP PF07454.9 T218394_1 - 2.2 7.5 12.7 3 7.1 12.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FLO_LFY PF01698.14 T218394_1 - 4 6.4 23.6 5.7 5.9 23.6 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein DDHD PF02862.15 T218394_1 - 4.1 7.3 7.3 5.6 6.9 7.3 1.1 1 0 0 1 1 1 0 DDHD domain DUF3807 PF12720.5 T218394_1 - 4.9 7.3 21.6 7 6.8 21.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Zip PF02535.20 T218394_1 - 9.3 5.2 6.4 12 4.9 6.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Rrn6 PF10214.7 T218394_2 - 0.0058 15.0 12.5 0.0091 14.3 12.5 1.2 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor DUF3682 PF12446.6 T218394_2 - 1.7 9.0 4.6 3.4 8.0 4.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) MIP-T3 PF10243.7 T218394_2 - 1.9 7.0 20.9 2.5 6.6 20.9 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CDC45 PF02724.12 T218394_2 - 2.3 6.3 18.3 3 5.9 18.3 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.11 T218394_3 - 0.17 10.5 6.3 0.22 10.1 6.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Eapp_C PF10238.7 T218394_3 - 0.58 10.1 3.4 0.84 9.6 3.4 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Presenilin PF01080.15 T218394_3 - 0.78 8.3 5.0 1.1 7.8 5.0 1.2 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.10 T218394_3 - 2 6.4 19.8 2.6 6.0 19.8 1.0 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.4 T218394_3 - 5.4 7.4 20.6 9.1 6.7 20.6 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FYDLN_acid PF09538.8 T218394_3 - 6 7.5 16.0 10 6.7 16.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Afi1 PF07792.10 T218394_3 - 6.9 7.0 8.6 11 6.3 8.6 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Ephrin_rec_like PF07699.11 T196599_1 - 0.32 10.7 9.6 0.5 10.0 5.8 2.4 1 1 1 2 2 2 0 Putative ephrin-receptor like TNFR_c6 PF00020.16 T196599_1 - 9.2 6.6 8.8 1.9 8.9 3.6 2.4 2 0 0 2 2 2 0 TNFR/NGFR cysteine-rich region DUF1725 PF08333.9 T032434_2 - 0.0069 15.9 1.3 0.013 15.0 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) TFIIA PF03153.11 T203106_1 - 1.5 8.6 6.3 2.2 8.0 6.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SspN PF08177.9 T276598_3 - 0.77 9.6 23.4 37 4.2 0.3 8.2 3 3 8 12 12 12 0 Small acid-soluble spore protein N family DUF1967 PF09269.9 T276598_3 - 6 6.8 20.3 84 3.1 0.1 8.2 3 3 4 9 9 9 0 Domain of unknown function (DUF1967) DUF1163 PF06651.9 T002406_1 - 0.58 10.1 3.7 5.7 7.0 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1163) Tat PF00539.16 T141842_2 - 1.8 8.7 4.9 16 5.6 0.2 3.4 3 0 0 3 3 3 0 Transactivating regulatory protein (Tat) TLV_coat PF00429.17 T306119_1 - 6.3e-44 150.5 1.6 1e-43 149.8 1.6 1.3 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RNase_H PF00075.22 T306119_1 - 2.8e-09 37.2 0.0 3.9e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 RNase H rve PF00665.24 T306119_1 - 7.1e-06 26.1 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.18 T306119_1 - 3.2e-05 24.0 0.0 5.6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.21 T306119_2 - 0.12 12.4 1.1 4.6 7.4 0.0 2.9 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.25 T306119_3 - 1.4e-18 67.1 0.0 2e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T306119_3 - 4.5e-12 45.8 0.1 8e-12 45.0 0.1 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein rve_3 PF13683.4 T306119_3 - 0.012 15.2 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain rve PF00665.24 T306119_3 - 0.022 14.8 0.0 0.037 14.1 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain zf-H2C2 PF09337.8 T026664_3 - 3.3e-06 27.1 0.0 8.3e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Trypan_PARP PF05887.9 T181583_1 - 0.0036 17.2 15.0 0.0062 16.4 15.0 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Tim54 PF11711.6 T181583_1 - 1.2 7.7 5.6 1.7 7.2 5.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TonB_N PF16031.3 T181583_2 - 0.00023 21.5 19.9 0.00023 21.5 19.9 1.7 2 0 0 2 2 2 1 TonB N-terminal region Trypan_PARP PF05887.9 T181583_2 - 0.22 11.4 13.1 0.47 10.4 13.1 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Corona_nucleoca PF00937.16 T181583_3 - 0.26 10.1 18.5 0.41 9.5 18.5 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Transformer PF06495.9 T181583_3 - 4.9 7.1 25.7 9.5 6.1 25.7 1.4 1 0 0 1 1 1 0 Fruit fly transformer protein rve PF00665.24 T236801_1 - 4.9e-09 36.3 0.0 8.5e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T236801_1 - 0.0025 17.2 0.0 0.004 16.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_MA PF01140.17 T236801_2 - 0.0014 18.2 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 Matrix protein (MA), p15 Gag_p30 PF02093.14 T236801_3 - 7.2e-27 94.2 1.5 1.5e-25 89.8 0.1 2.2 2 0 0 2 2 2 1 Gag P30 core shell protein Transposase_22 PF02994.12 T236801_3 - 7.5e-13 47.9 0.5 1.2e-12 47.3 0.5 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T236801_3 - 6e-07 29.1 0.0 9.6e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RBP_receptor PF14752.4 T358356_1 - 5.5e-40 137.4 2.0 7.1e-40 137.1 2.0 1.1 1 0 0 1 1 1 1 Retinol binding protein receptor cNMP_binding PF00027.27 T265029_2 - 9.1e-05 22.3 0.0 0.00013 21.8 0.0 1.1 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Gly-zipper_YMGG PF13441.4 T173635_2 - 0.046 13.3 1.5 0.09 12.4 1.5 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper DUF1669 PF07894.10 T294483_1 - 3.3e-17 62.8 0.3 5.7e-17 62.0 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) DUF2722 PF10846.6 T143627_1 - 0.031 13.1 0.7 0.045 12.6 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Corona_nucleoca PF00937.16 T143627_2 - 0.52 9.2 4.2 0.75 8.6 4.2 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein RSRP PF17069.3 T143627_2 - 0.93 8.9 11.5 1.3 8.4 11.5 1.1 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 DUF4705 PF15788.3 T323259_1 - 0.0069 16.4 34.3 0.025 14.7 15.5 5.1 3 1 1 4 4 4 2 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323259_3 - 3.6e-05 23.8 22.5 0.00032 20.7 6.3 7.8 7 2 2 9 9 9 2 Domain of unknown function (DUF4705) zf-CCHC PF00098.21 T190064_1 - 0.0027 17.6 3.4 0.0095 15.9 3.4 2.0 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.4 T190064_1 - 1.3 8.7 15.1 1.5 8.4 1.3 3.5 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger DUF4705 PF15788.3 T323209_1 - 3.3e-115 376.0 531.8 4e-17 62.0 8.0 47.2 26 15 19 45 45 45 33 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323209_2 - 2.5e-58 194.0 524.6 1.5e-15 57.0 9.2 45.3 30 12 11 42 42 42 28 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323209_3 - 3e-23 81.6 53.6 1.9e-11 43.8 11.0 43.0 26 12 13 39 39 39 19 Domain of unknown function (DUF4705) Pentapeptide_2 PF01469.16 T051538_1 - 0.0055 16.4 6.3 0.51 10.1 1.1 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) DUF1510 PF07423.9 T275900_1 - 0.012 14.9 0.0 0.04 13.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF912 PF06024.10 T275900_1 - 0.045 13.9 0.0 0.17 12.1 0.0 1.9 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) LRRC37AB_C PF14914.4 T275900_1 - 0.057 13.2 0.2 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain ODV-E18 PF10717.7 T275900_1 - 0.3 10.8 5.6 0.6 9.9 5.6 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF3446 PF11928.6 T275900_2 - 0.1 12.8 11.5 0.22 11.7 11.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) SR-25 PF10500.7 T275900_2 - 4 6.8 12.4 6.2 6.2 12.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein KIAA1430 PF13879.4 T099989_2 - 8e-12 45.7 0.2 1.9e-11 44.5 0.2 1.6 1 0 0 1 1 1 1 KIAA1430 homologue RabGAP-TBC PF00566.16 T143994_2 - 0.018 14.6 0.2 0.026 14.0 0.2 1.2 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Peptidase_M24_C PF16188.3 T227647_1 - 1.6 8.7 3.3 3e+02 1.5 0.1 4.9 4 2 1 5 5 5 0 C-terminal region of peptidase_M24 Med28 PF11594.6 T227647_2 - 0.019 14.9 13.4 28 4.6 0.1 7.6 3 2 6 9 9 9 0 Mediator complex subunit 28 dUTPase PF00692.17 T331173_3 - 6.3e-11 41.9 0.0 1.1e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 dUTPase rve PF00665.24 T331173_3 - 1.3e-05 25.3 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.3 T222942_1 - 4.1 7.1 10.3 10 5.8 1.9 2.7 2 0 0 2 2 2 0 C2H2 zinc-finger Filament PF00038.19 T078934_1 - 1.8e-15 57.2 1.9 2.4e-15 56.8 1.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament PF00038.19 T078934_2 - 5.8e-19 68.7 4.9 7.4e-19 68.3 4.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein BRE1 PF08647.9 T078934_2 - 0.58 10.1 3.0 0.84 9.6 3.0 1.1 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Calponin PF00402.16 T184347_3 - 0.036 13.6 2.0 59 3.3 0.0 5.7 7 0 0 7 7 7 0 Calponin family repeat Fels1 PF05666.9 T196780_2 - 8.2e-05 22.0 70.3 5.7 6.5 0.1 28.4 33 0 0 33 33 33 1 Fels-1 Prophage Protein-like Transketolase_N PF00456.19 T196780_3 - 0.00073 18.4 22.1 4.2 6.1 0.1 10.2 4 2 4 11 11 11 5 Transketolase, thiamine diphosphate binding domain ELK PF03789.11 T196780_3 - 0.0067 16.3 0.4 4.3e+02 1.0 0.0 6.9 5 0 0 5 5 5 0 ELK domain TLV_coat PF00429.17 T129142_1 - 2.8e-09 36.1 0.3 4.3e-09 35.5 0.3 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Gag_p30 PF02093.14 T129142_1 - 0.00011 21.7 0.0 0.00018 21.0 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RNase_H PF00075.22 T129142_3 - 0.00022 21.3 0.0 0.00038 20.5 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T129142_3 - 0.038 13.4 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein CTD PF12815.5 T259452_1 - 2.2e-10 40.8 48.4 1.3e-06 28.7 17.2 4.0 1 1 1 2 2 2 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Mucin-like PF16058.3 T259452_2 - 5.7e-07 29.4 35.5 1.4e-05 24.9 10.3 9.4 5 1 4 9 9 9 3 Mucin-like CTD PF12815.5 T259452_3 - 6.7e-15 55.3 102.3 1.1e-06 29.0 16.0 4.8 3 1 3 6 6 6 4 Spt5 C-terminal nonapeptide repeat binding Spt4 Serpin PF00079.18 T295988_2 - 1.8e-05 24.1 0.0 2.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Arylesterase PF01731.18 T381567_1 - 0.052 13.6 0.0 0.099 12.7 0.0 1.4 1 0 0 1 1 1 0 Arylesterase RVT_1 PF00078.25 T119713_1 - 2.8e-23 82.5 1.9 4.3e-23 81.9 1.9 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T119713_2 - 1e-112 376.5 20.4 1.8e-110 369.1 20.4 2.4 1 1 0 1 1 1 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T119713_2 - 5.9e-06 26.0 2.1 6.5e-06 25.9 0.5 2.0 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T119713_2 - 0.00052 20.1 0.0 0.0025 17.9 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1725 PF08333.9 T110428_2 - 1.3e-08 34.1 0.8 3.3e-08 32.8 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF3432 PF11914.6 T370304_3 - 0.069 13.3 46.4 26 5.0 7.8 5.6 1 1 2 3 3 3 0 Domain of unknown function (DUF3432) DUF2551 PF10826.6 T370304_3 - 1.7 8.8 7.3 19 5.4 0.6 3.7 3 2 1 4 4 4 0 Protein of unknown function (DUF2551) SEA PF01390.18 T119768_1 - 0.00023 21.3 0.0 0.079 13.1 0.0 2.2 2 0 0 2 2 2 2 SEA domain RESP18 PF14948.4 T208132_1 - 9e-14 51.6 0.1 1.3e-13 51.1 0.1 1.2 1 0 0 1 1 1 1 RESP18 domain Transposase_22 PF02994.12 T190843_1 - 6.6e-46 156.7 2.6 9e-46 156.3 2.6 1.1 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T190843_2 - 3.5e-58 197.1 15.9 5.8e-58 196.4 15.9 1.3 1 0 0 1 1 1 1 L1 transposable element Seryl_tRNA_N PF02403.20 T190843_2 - 0.0008 19.5 8.0 0.0014 18.7 8.0 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain GAS PF13851.4 T190843_2 - 0.0028 16.9 10.7 0.0047 16.2 10.7 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding IncA PF04156.12 T190843_2 - 0.0045 16.7 9.8 0.007 16.0 9.8 1.2 1 0 0 1 1 1 1 IncA protein TBPIP PF07106.11 T190843_2 - 0.0051 16.5 8.2 0.0051 16.5 8.2 2.1 1 1 1 2 2 2 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Atg14 PF10186.7 T190843_2 - 0.0071 15.3 9.8 0.012 14.6 9.8 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 ATG16 PF08614.9 T190843_2 - 0.0087 16.1 13.6 0.028 14.5 13.5 1.8 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) Syntaxin-6_N PF09177.9 T190843_2 - 0.012 16.0 6.4 0.028 14.9 6.4 1.6 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Spectrin PF00435.19 T190843_2 - 0.012 15.9 5.5 0.03 14.7 5.5 1.6 1 0 0 1 1 1 0 Spectrin repeat Sec34 PF04136.13 T190843_2 - 0.014 15.2 3.0 0.026 14.3 3.0 1.4 1 0 0 1 1 1 0 Sec34-like family APG6 PF04111.10 T190843_2 - 0.029 13.6 12.2 0.043 13.1 12.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF342 PF03961.11 T190843_2 - 0.033 12.7 4.4 0.048 12.1 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Stanniocalcin PF03298.11 T190843_2 - 0.047 12.9 1.6 0.071 12.3 1.6 1.2 1 0 0 1 1 1 0 Stanniocalcin family DUF16 PF01519.14 T190843_2 - 0.051 13.9 7.6 1 9.8 7.5 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF1664 PF07889.10 T190843_2 - 0.059 13.2 2.1 0.099 12.5 2.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) KLRAQ PF10205.7 T190843_2 - 0.084 13.0 9.8 0.16 12.1 8.8 2.0 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Mnd1 PF03962.13 T190843_2 - 0.13 11.9 10.0 0.22 11.3 10.0 1.3 1 0 0 1 1 1 0 Mnd1 family DUF812 PF05667.9 T190843_2 - 0.14 10.9 15.4 0.21 10.3 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF4613 PF15390.4 T190843_2 - 0.23 9.7 7.1 0.32 9.2 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Med2 PF11214.6 T190843_2 - 0.27 11.3 6.9 0.035 14.1 2.5 1.8 1 1 1 2 2 2 0 Mediator complex subunit 2 Sec8_exocyst PF04048.12 T190843_2 - 0.44 10.3 3.1 1.7 8.4 0.4 2.1 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain P4Ha_N PF08336.9 T190843_2 - 0.61 10.0 5.0 0.7 9.8 4.1 1.5 1 1 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Jnk-SapK_ap_N PF09744.7 T190843_2 - 1.1 9.4 14.7 2 8.5 14.7 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ADIP PF11559.6 T190843_2 - 1.1 9.1 11.2 3.2 7.7 11.0 1.7 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.10 T190843_2 - 1.2 9.1 12.0 4.9 7.1 12.0 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein ATP-synt_D PF01813.15 T190843_2 - 1.4 8.6 9.2 2.6 7.7 9.2 1.4 1 0 0 1 1 1 0 ATP synthase subunit D Occludin_ELL PF07303.11 T190843_2 - 2 9.0 6.8 2.4 8.8 4.3 2.0 1 1 1 2 2 2 0 Occludin homology domain Exonuc_VII_L PF02601.13 T190843_2 - 2.3 7.6 5.6 3.3 7.1 5.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Syntaxin_2 PF14523.4 T190843_2 - 2.3 8.5 7.1 8.9 6.6 0.6 2.4 1 1 1 2 2 2 0 Syntaxin-like protein DUF972 PF06156.11 T190843_2 - 4 8.0 10.4 2.1 8.9 7.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF2203 PF09969.7 T190843_2 - 6 7.5 8.0 2.4 8.8 4.1 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) JIP_LZII PF16471.3 T190843_2 - 6.2 6.9 11.8 2.1 8.4 4.4 2.4 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II OmpH PF03938.12 T190843_2 - 7.3 6.4 11.2 1.1 9.1 5.8 1.9 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Spc24 PF08286.9 T190843_2 - 8.9 6.5 7.9 5.6 7.1 5.8 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DCR PF14047.4 T199691_2 - 2.9 8.0 5.3 3.7 7.6 0.1 3.3 3 0 0 3 3 3 0 Dppa2/4 conserved region zf-C2H2_10 PF16588.3 T199691_3 - 4.8 6.9 10.8 12 5.6 1.9 2.7 2 0 0 2 2 2 0 C2H2 zinc-finger BAGE PF08180.9 T295451_2 - 4.8e-10 39.2 3.3 4.8e-10 39.2 3.3 2.2 2 0 0 2 2 2 1 B melanoma antigen family MIP-T3 PF10243.7 T061274_3 - 0.43 9.1 60.2 0.55 8.8 60.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Gag_p24 PF00607.18 T336587_1 - 7.4e-40 136.9 0.0 1e-39 136.4 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) Integrase_Zn PF02022.17 T336587_1 - 3.6e-14 52.3 2.3 1e-13 50.8 2.3 1.9 1 0 0 1 1 1 1 Integrase Zinc binding domain RNase_H PF00075.22 T336587_1 - 1.3e-12 48.0 0.0 2.1e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T336587_1 - 2.2e-07 30.5 0.0 3.6e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T336587_1 - 0.00014 21.9 0.0 0.00027 21.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.21 T336587_1 - 0.0036 17.2 6.2 0.0036 17.2 6.2 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.4 T336587_1 - 0.08 12.5 2.5 0.18 11.4 2.5 1.6 1 0 0 1 1 1 0 Zinc knuckle RVP PF00077.18 T336587_2 - 1.4e-24 86.1 0.1 2.8e-24 85.2 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease dUTPase PF00692.17 T336587_2 - 7.4e-20 70.8 0.0 1.3e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 dUTPase G-patch PF01585.21 T336587_2 - 1.2e-07 31.4 1.1 2.7e-07 30.2 1.1 1.6 1 0 0 1 1 1 1 G-patch domain HERV-K_env_2 PF13804.4 T336587_2 - 3e-05 23.7 0.1 4.8e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein gag-asp_proteas PF13975.4 T336587_2 - 0.072 13.5 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_5 PF14787.4 T336587_3 - 2.1e-14 52.8 1.0 4.5e-14 51.7 1.0 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger rve PF00665.24 T336587_3 - 3.2e-08 33.7 0.0 7.2e-08 32.5 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain IN_DBD_C PF00552.19 T336587_3 - 8.2e-08 31.3 2.6 1.5e-07 30.4 2.6 1.4 1 0 0 1 1 1 1 Integrase DNA binding domain HERV-K_REC PF15695.3 T336587_3 - 0.0027 17.6 0.3 0.0064 16.4 0.3 1.6 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 CTD PF12815.5 T259443_1 - 1.3e-13 51.2 91.6 1.5e-06 28.5 16.2 8.5 6 1 3 9 9 9 6 Spt5 C-terminal nonapeptide repeat binding Spt4 CTD PF12815.5 T259443_2 - 2.2e-17 63.3 99.7 2.1e-06 28.1 17.6 6.5 4 2 2 6 6 6 4 Spt5 C-terminal nonapeptide repeat binding Spt4 Mucin-like PF16058.3 T259443_3 - 1.3e-06 28.2 35.8 1.8e-05 24.6 10.3 12.2 7 1 6 14 14 14 4 Mucin-like Caskin1-CID PF16600.3 T259443_3 - 0.094 13.2 1.2 1.8e+02 2.7 0.0 4.8 5 0 0 5 5 5 0 Caskin1 CASK-interaction domain Tetraspannin PF00335.18 T316993_1 - 0.078 12.7 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Tetraspanin family Transposase_1 PF01359.16 T351100_1 - 5.2e-21 74.2 7.5 1.5e-20 72.6 4.6 2.7 2 0 0 2 2 2 1 Transposase (partial DDE domain) DDE_3 PF13358.4 T351100_1 - 0.0028 17.3 0.4 0.0051 16.4 0.4 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BEN PF10523.7 T351100_1 - 0.053 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 BEN domain Transposase_1 PF01359.16 T351100_3 - 0.037 13.8 0.1 0.08 12.7 0.1 1.4 1 0 0 1 1 1 0 Transposase (partial DDE domain) Mito_fiss_reg PF05308.9 T018928_3 - 3.6 7.5 5.8 7.1 6.5 5.8 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.3 T018928_3 - 5.4 6.9 15.5 2 8.4 11.5 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Gag_p30 PF02093.14 T289428_1 - 5.7e-06 25.9 0.0 8.5e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein zf-CCHC PF00098.21 T289428_1 - 6.2e-05 22.8 1.6 0.00013 21.7 1.6 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.4 T289428_1 - 0.057 13.3 1.6 0.12 12.2 1.6 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.4 T289428_1 - 1.5 8.4 10.9 0.43 10.2 4.2 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Anti-TRAP PF15777.3 T289428_1 - 6.2 6.7 6.6 12 5.8 6.6 1.4 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein RNase_H PF00075.22 T289428_3 - 1.1e-16 61.2 0.0 1.5e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T289428_3 - 0.00011 21.7 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Harakiri PF15196.4 T379041_1 - 1.2e-05 25.5 9.5 3.3e-05 24.1 9.5 1.7 1 0 0 1 1 1 1 Activator of apoptosis harakiri Harakiri PF15196.4 T379041_3 - 1.3e-06 28.7 0.9 2.3e-06 27.8 0.9 1.4 1 0 0 1 1 1 1 Activator of apoptosis harakiri rve PF00665.24 T321832_1 - 1.8e-27 95.8 0.1 2.5e-27 95.3 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain IN_DBD_C PF00552.19 T321832_1 - 3.5e-10 38.9 1.4 5.5e-10 38.2 1.4 1.3 1 0 0 1 1 1 1 Integrase DNA binding domain rve_3 PF13683.4 T321832_1 - 0.052 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain Transposase_22 PF02994.12 T279630_1 - 3.2e-16 59.0 0.4 2.9e-09 36.2 0.0 2.3 2 0 0 2 2 2 2 L1 transposable element Transposase_22 PF02994.12 T279630_2 - 1.8e-08 33.5 6.2 0.0014 17.4 0.0 3.2 3 0 0 3 3 3 3 L1 transposable element RVT_1 PF00078.25 T279630_2 - 7.3e-05 22.3 0.3 0.00012 21.5 0.3 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T279630_3 - 2.6e-32 112.0 7.1 2.6e-31 108.7 7.1 2.2 1 1 0 1 1 1 1 L1 transposable element KIAA1430 PF13879.4 T099980_2 - 7.6e-14 52.2 1.2 1.6e-13 51.2 1.2 1.5 1 0 0 1 1 1 1 KIAA1430 homologue Toxin_13 PF07822.9 T229249_2 - 0.011 15.7 0.3 0.028 14.4 0.3 1.6 1 0 0 1 1 1 0 Neurotoxin B-IV-like protein zf-AN1 PF01428.14 T146029_1 - 3 7.9 6.2 10 6.3 2.4 2.8 2 0 0 2 2 2 0 AN1-like Zinc finger Gag_p30 PF02093.14 T297828_3 - 0.00037 19.9 0.0 0.00062 19.2 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T297828_3 - 0.0098 15.3 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Yae1_N PF09811.7 T129273_1 - 0.00057 19.4 12.6 0.0072 15.9 12.6 2.1 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Yae1_N PF09811.7 T129273_2 - 0.018 14.6 11.8 0.084 12.5 11.8 1.9 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Yae1_N PF09811.7 T129273_3 - 0.00094 18.7 12.3 0.018 14.6 12.3 2.3 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Transposase_22 PF02994.12 T055761_1 - 3.6e-71 239.8 2.3 5.1e-71 239.3 2.3 1.1 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T055761_1 - 1e-09 38.5 0.0 1.7e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T055761_1 - 3.6e-07 29.9 0.3 7.4e-07 28.9 0.3 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Transposase_22 PF02994.12 T055761_2 - 2e-53 181.4 16.0 5.8e-53 179.9 16.0 1.6 1 1 0 1 1 1 1 L1 transposable element Syntaxin-6_N PF09177.9 T055761_2 - 0.012 16.0 4.1 0.024 15.1 4.1 1.4 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Seryl_tRNA_N PF02403.20 T055761_2 - 0.013 15.5 0.8 0.025 14.7 0.8 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.12 T055761_2 - 0.088 12.5 2.7 0.14 11.8 2.7 1.3 1 0 0 1 1 1 0 IncA protein HSBP1 PF06825.10 T055761_2 - 0.18 11.6 3.9 0.15 11.9 0.4 2.2 1 1 1 2 2 2 0 Heat shock factor binding protein 1 Transposase_22 PF02994.12 T203335_3 - 2.6e-104 348.8 15.3 5.7e-104 347.7 15.3 1.5 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T203335_3 - 1.2e-33 116.4 0.2 2.3e-33 115.4 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1664 PF07889.10 T203335_3 - 0.01 15.7 4.1 0.47 10.3 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sec34 PF04136.13 T203335_3 - 0.019 14.7 2.0 0.046 13.5 2.0 1.6 1 0 0 1 1 1 0 Sec34-like family Spectrin PF00435.19 T203335_3 - 0.034 14.5 5.6 0.095 13.1 5.6 1.7 1 0 0 1 1 1 0 Spectrin repeat zf-C4H2 PF10146.7 T203335_3 - 0.041 14.0 13.1 0.019 15.2 8.6 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein KLRAQ PF10205.7 T203335_3 - 0.11 12.6 4.4 0.41 10.8 4.4 2.0 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Prominin PF05478.9 T203335_3 - 0.16 9.8 2.5 0.29 8.9 2.5 1.3 1 0 0 1 1 1 0 Prominin Syntaxin-6_N PF09177.9 T203335_3 - 0.42 11.1 9.5 0.079 13.4 5.2 2.0 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Med2 PF11214.6 T203335_3 - 0.43 10.6 6.8 0.14 12.2 2.2 2.6 2 1 0 2 2 2 0 Mediator complex subunit 2 DUF16 PF01519.14 T203335_3 - 5.6 7.4 8.0 1.1 9.6 2.6 2.6 2 1 1 3 3 3 0 Protein of unknown function DUF16 Transposase_22 PF02994.12 T293916_2 - 1.4e-09 37.2 4.1 2.1e-09 36.6 4.1 1.1 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T293916_3 - 1.4e-18 66.8 2.8 1.9e-18 66.3 2.8 1.2 1 0 0 1 1 1 1 L1 transposable element DUF1669 PF07894.10 T293916_3 - 1.2e-15 57.7 0.1 1.9e-15 57.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) DUF16 PF01519.14 T293916_3 - 0.17 12.2 2.1 0.31 11.4 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 XhlA PF10779.7 T293916_3 - 3 8.0 6.2 7.7 6.7 0.8 2.3 2 0 0 2 2 2 0 Haemolysin XhlA Transposase_22 PF02994.12 T228191_2 - 1.1e-07 30.9 0.2 2.1e-07 30.0 0.2 1.3 1 0 0 1 1 1 1 L1 transposable element DUF912 PF06024.10 T089749_3 - 0.055 13.6 1.9 9.5 6.4 0.3 3.9 4 0 0 4 4 4 0 Nucleopolyhedrovirus protein of unknown function (DUF912) FAP PF07174.9 T089749_3 - 1.7 7.9 32.4 0.28 10.4 14.8 2.8 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) RNase_H PF00075.22 T172342_3 - 2.9e-05 24.2 0.0 5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 RNase H DDE_1 PF03184.17 T208585_1 - 4e-06 26.4 0.0 6.4e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.17 T208585_3 - 0.00062 19.3 0.1 0.0021 17.5 0.1 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF1510 PF07423.9 T275905_1 - 0.012 14.9 3.0 0.012 14.9 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1510) LRRC37AB_C PF14914.4 T275905_1 - 0.014 15.2 0.2 0.038 13.8 0.2 1.7 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF912 PF06024.10 T275905_1 - 0.055 13.6 0.2 0.055 13.6 0.2 2.6 2 2 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) EphA2_TM PF14575.4 T275905_1 - 0.088 13.5 0.2 0.088 13.5 0.2 7.7 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ODV-E18 PF10717.7 T275905_1 - 0.12 12.2 5.6 0.2 11.4 5.6 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 TMEM154 PF15102.4 T275905_1 - 0.16 11.8 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF3446 PF11928.6 T275905_1 - 0.26 11.5 7.3 1.1 9.5 7.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) DUF3446 PF11928.6 T275905_2 - 0.03 14.5 11.6 0.077 13.2 11.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) SR-25 PF10500.7 T275905_2 - 1.4 8.4 12.4 2.1 7.8 12.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SelP_N PF04592.12 T275905_2 - 3.1 7.0 17.9 4.9 6.4 17.9 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF912 PF06024.10 T275905_3 - 1.7 8.8 0.0 1.7 8.8 0.0 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) RVT_1 PF00078.25 T091125_2 - 1.5e-07 31.0 0.0 2.4e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Arylesterase PF01731.18 T381543_1 - 0.05 13.7 0.0 0.095 12.8 0.0 1.4 1 0 0 1 1 1 0 Arylesterase Sec3-PIP2_bind PF15277.4 T265034_2 - 5.2e-22 77.7 0.4 8.3e-22 77.0 0.4 1.2 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH dUTPase PF00692.17 T076044_1 - 1.7e-10 40.6 0.0 3e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 dUTPase rve PF00665.24 T076044_1 - 6.3e-05 23.0 0.1 0.00011 22.3 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T076044_1 - 0.00013 22.1 1.2 0.0061 16.6 0.0 2.6 3 0 0 3 3 3 1 RNase H Transposase_1 PF01359.16 T037512_1 - 1.6e-22 79.0 1.2 3.1e-22 78.1 0.5 1.9 1 1 1 2 2 2 1 Transposase (partial DDE domain) Hexapep PF00132.22 T336907_1 - 0.0016 17.9 0.0 10 5.9 0.0 3.9 2 2 3 5 5 5 3 Bacterial transferase hexapeptide (six repeats) DUF1725 PF08333.9 T238322_1 - 0.00038 19.9 1.2 0.59 9.7 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF1725) DDHD PF02862.15 T238322_2 - 6.3 6.7 6.6 11 5.9 6.6 1.2 1 0 0 1 1 1 0 DDHD domain DUF2207 PF09972.7 T153291_3 - 0.085 11.5 2.7 0.2 10.3 2.7 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RNA_pol_3_Rpc31 PF11705.6 T153291_3 - 2.6 8.1 16.7 4.2 7.4 16.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 AAA_9 PF12781.5 T353755_1 - 6e-06 25.4 0.0 9.1e-06 24.8 0.0 1.2 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 DUF1664 PF07889.10 T353755_2 - 1.2 9.0 4.3 1.8 8.5 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Sec8_exocyst PF04048.12 T111722_2 - 0.12 12.2 1.6 0.19 11.5 1.6 1.2 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Transposase_22 PF02994.12 T111722_3 - 0.0013 17.5 3.8 0.0015 17.3 2.2 1.7 2 0 0 2 2 2 1 L1 transposable element MdoG PF04349.10 T125888_3 - 0.041 12.7 0.4 0.059 12.2 0.4 1.1 1 0 0 1 1 1 0 Periplasmic glucan biosynthesis protein, MdoG rve PF00665.24 T362404_1 - 6e-14 52.1 0.0 9.9e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.21 T362404_1 - 6.9e-06 25.8 2.5 6.9e-06 25.8 2.5 2.7 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_2 PF13696.4 T362404_1 - 0.15 11.8 6.7 0.62 9.8 4.3 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.4 T362404_1 - 0.9 9.2 7.5 2.4 7.8 3.5 2.7 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Gag_p30 PF02093.14 T362404_2 - 2.5e-15 56.4 0.1 3.7e-15 55.9 0.1 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T362404_2 - 1.7e-11 44.0 0.1 5.3e-11 42.3 0.1 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.18 T362404_2 - 2e-09 37.5 0.0 3.5e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease TLV_coat PF00429.17 T362404_2 - 9.4e-06 24.4 0.7 1.4e-05 23.8 0.7 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RNase_H PF00075.22 T362404_2 - 0.0035 17.4 0.0 0.0058 16.7 0.0 1.3 1 0 0 1 1 1 1 RNase H Asp_protease_2 PF13650.4 T362404_2 - 0.026 15.1 0.1 0.048 14.2 0.1 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T362404_2 - 0.043 14.2 0.0 0.079 13.4 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease FXR_C1 PF16096.3 T069826_2 - 0.67 10.1 2.2 1.3 9.1 2.2 1.4 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 DUF1725 PF08333.9 T277130_2 - 0.046 13.3 0.1 0.091 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Tektin PF03148.12 T383224_1 - 6.1e-05 21.8 0.0 8.9e-05 21.3 0.0 1.1 1 0 0 1 1 1 1 Tektin family Tektin PF03148.12 T383224_2 - 6.8e-19 67.7 0.0 9.7e-19 67.2 0.0 1.1 1 0 0 1 1 1 1 Tektin family SPAM PF02090.13 T383224_2 - 0.051 13.2 0.1 0.086 12.5 0.1 1.2 1 0 0 1 1 1 0 Salmonella surface presentation of antigen gene type M protein Tektin PF03148.12 T383224_3 - 7.4e-28 97.2 8.0 3e-26 91.9 3.3 2.1 2 0 0 2 2 2 2 Tektin family RVT_1 PF00078.25 T337381_1 - 9.4e-10 38.2 0.0 1.5e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T337381_2 - 1.6e-37 129.1 0.8 2.6e-37 128.4 0.8 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T337381_3 - 9.1e-05 21.9 0.0 0.00019 20.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1736 PF08409.9 T337114_1 - 0.01 15.7 0.1 27 4.7 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1736) PAS_4 PF08448.8 T337114_3 - 1.7 8.8 4.2 65 3.7 0.1 3.3 3 0 0 3 3 3 0 PAS fold HHV-5_US34A PF17087.3 T337114_3 - 3.5 7.7 11.3 14 5.8 0.4 3.3 3 0 0 3 3 3 0 Herpesvirus US34A protein family MRP-L28 PF09812.7 T369097_3 - 1.9 8.5 5.5 3.8 7.5 5.5 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 RVP PF00077.18 T120907_1 - 0.014 15.6 0.0 0.047 13.8 0.0 1.8 2 0 0 2 2 2 0 Retroviral aspartyl protease RNase_H PF00075.22 T120907_1 - 0.023 14.8 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 RNase H Gag_p30 PF02093.14 T120907_1 - 0.076 12.4 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein rve PF00665.24 T120907_2 - 1.1e-07 31.9 0.1 7e-07 29.3 0.1 2.1 1 1 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T120907_2 - 0.021 14.9 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 RNase H RVT_1 PF00078.25 T120907_2 - 0.082 12.3 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T120907_3 - 2.5e-05 24.0 2.4 2.5e-05 24.0 2.4 2.9 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T120907_3 - 3.5 7.3 11.8 0.12 12.0 2.6 2.8 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.4 T120907_3 - 9.1 6.1 8.8 1.1 9.0 3.1 2.4 2 0 0 2 2 2 0 Zinc knuckle Methyltransf_6 PF03737.13 T374596_1 - 0.072 13.1 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Demethylmenaquinone methyltransferase RVT_1 PF00078.25 T374596_3 - 1.6e-07 30.9 0.0 2.5e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BAGE PF08180.9 T295453_2 - 1e-10 41.3 3.3 1.5e-10 40.8 3.3 1.2 1 0 0 1 1 1 1 B melanoma antigen family Pentapeptide_4 PF13599.4 T223095_1 - 5.6e-18 64.7 28.0 0.22 11.5 0.1 16.4 13 4 4 18 18 18 8 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T223095_2 - 2.5e-25 88.3 25.9 0.012 15.5 0.0 16.7 12 4 5 17 17 17 14 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T223095_3 - 1.2e-23 82.9 22.7 1.9 8.6 0.1 17.4 11 5 5 16 16 16 13 Pentapeptide repeats (9 copies) Gag_p30 PF02093.14 T159804_1 - 0.0059 16.0 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T159804_1 - 0.081 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC PF00098.21 T159804_3 - 1.7e-05 24.6 3.9 4.2e-05 23.3 3.9 1.8 1 0 0 1 1 1 1 Zinc knuckle RVT_1 PF00078.25 T159804_3 - 0.11 11.8 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_5 PF14787.4 T159804_3 - 2.1 8.0 9.1 5.9 6.6 2.8 2.8 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Pheromone PF08015.9 T026965_1 - 3.2 8.7 8.0 5.9 7.9 8.0 1.4 1 0 0 1 1 1 0 Fungal mating-type pheromone Pex14_N PF04695.11 T026965_3 - 0.056 14.0 5.1 0.092 13.3 5.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DDE_1 PF03184.17 T336747_1 - 1.3e-13 50.7 0.1 2.4e-13 49.9 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Epiglycanin_C PF14654.4 T300730_3 - 8.2e-05 22.5 0.3 0.0014 18.6 0.1 2.5 2 0 0 2 2 2 1 Mucin, catalytic, TM and cytoplasmic tail region HERV-K_env_2 PF13804.4 T202694_1 - 5.2e-37 127.1 0.2 8.3e-37 126.4 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GP41 PF00517.15 T202694_3 - 5.6e-10 39.3 0.3 9.4e-10 38.5 0.3 1.3 1 0 0 1 1 1 1 Retroviral envelope protein RNase_H PF00075.22 T172337_2 - 2.5e-05 24.4 0.0 4.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 RNase H DUF4705 PF15788.3 T323202_1 - 2.7e-73 241.9 500.5 3.5e-08 33.4 4.4 47.8 28 10 11 39 39 39 33 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323202_2 - 2.6e-59 197.1 513.5 1.2e-15 57.2 9.2 45.5 26 11 12 38 38 38 24 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323202_3 - 4.7e-82 269.9 487.7 3.4e-17 62.3 8.0 44.0 24 16 19 43 43 43 28 Domain of unknown function (DUF4705) PHO4 PF01384.18 T236011_1 - 4.6e-05 22.5 5.1 0.0007 18.6 0.0 2.7 3 0 0 3 3 3 2 Phosphate transporter family SUR7 PF06687.10 T236011_1 - 3.7 7.0 0.0 3.7 7.0 0.0 3.4 3 1 0 3 3 3 0 SUR7/PalI family Nop14 PF04147.10 T348694_2 - 0.89 7.6 17.4 1.3 7.0 17.4 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.10 T348694_2 - 5.8 6.1 19.5 8.6 5.6 19.5 1.1 1 0 0 1 1 1 0 SDA1 FoP_duplication PF13865.4 T004607_1 - 1.5 9.3 7.5 3.1 8.3 7.5 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 E7 PF00527.16 T004607_2 - 0.45 10.6 3.2 0.17 12.0 0.8 1.5 2 0 0 2 2 2 0 E7 protein, Early protein FAM176 PF14851.4 T004607_2 - 0.46 10.0 7.7 0.72 9.4 7.7 1.2 1 0 0 1 1 1 0 FAM176 family Nucleo_P87 PF07267.9 T004607_2 - 1.6 7.4 9.9 2 7.1 9.9 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4746 PF15928.3 T004607_2 - 1.8 7.8 9.4 2.4 7.4 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Pentapeptide PF00805.20 T138466_2 - 4.8e-05 22.8 1.0 0.28 10.7 0.1 5.0 5 0 0 5 5 5 2 Pentapeptide repeats (8 copies) Colipase-like PF15083.4 T090346_1 - 7.1e-47 157.3 26.0 2.8e-38 129.8 13.7 2.4 1 1 1 2 2 2 2 Colipase-like FAM27 PF15832.3 T174283_1 - 5.2e-08 33.2 29.1 1.5e-06 28.6 10.0 4.5 4 0 0 4 4 4 2 FAM27 D and E protein family FAM27 PF15832.3 T174283_2 - 1.6e-16 60.4 59.3 3.1e-09 37.1 17.9 5.0 7 0 0 7 7 7 3 FAM27 D and E protein family DUF1725 PF08333.9 T298495_1 - 9.8e-09 34.5 0.8 2.1e-08 33.5 0.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) VCX_VCY PF15231.4 T381764_3 - 3.8e-05 24.2 0.3 5.8e-05 23.6 0.3 1.1 1 0 0 1 1 1 1 Variable charge X/Y family FAM27 PF15832.3 T215851_3 - 9.5e-36 122.1 24.5 9.5e-36 122.1 24.5 4.1 4 0 0 4 4 4 1 FAM27 D and E protein family CLLAC PF15675.3 T036665_1 - 0.46 9.9 5.2 1.5 8.3 5.2 1.9 1 0 0 1 1 1 0 CLLAC-motif containing domain Transposase_22 PF02994.12 T103728_3 - 2.1e-142 474.2 20.5 2.9e-142 473.7 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103728_3 - 0.03 14.4 0.0 0.057 13.6 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103728_3 - 0.06 13.0 10.5 0.11 12.1 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103728_3 - 0.061 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103728_3 - 0.35 11.3 5.0 0.7 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103728_3 - 0.43 9.8 12.3 0.74 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103728_3 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103728_3 - 3 8.0 7.5 5.3 7.2 6.7 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein DUF732 PF05305.12 T259483_1 - 0.14 12.4 4.0 11 6.4 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF732) DUF732 PF05305.12 T259483_3 - 0.047 13.9 1.5 14 6.0 0.0 3.6 3 1 0 4 4 4 0 Protein of unknown function (DUF732) YmaF PF12788.5 T294300_2 - 0.0054 17.1 1.8 0.26 11.7 0.4 2.3 1 1 1 2 2 2 2 YmaF family DDE_1 PF03184.17 T371835_2 - 3.3e-37 127.6 0.4 4.6e-37 127.1 0.4 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 T371835_3 - 0.0091 15.9 0.2 0.024 14.5 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Sporozoite_P67 PF05642.9 T099749_3 - 0.65 7.9 1.4 1.1 7.1 1.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen zf-CCHC PF00098.21 T172259_2 - 6.5e-05 22.7 3.2 6.5e-05 22.7 3.2 3.1 2 0 0 2 2 2 1 Zinc knuckle Transposase_22 PF02994.12 T172259_3 - 1.2e-25 90.1 3.2 1.6e-25 89.6 0.9 1.9 2 0 0 2 2 2 1 L1 transposable element Gag_p30 PF02093.14 T172259_3 - 0.011 15.1 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein RNase_H PF00075.22 T377272_1 - 3.3e-07 30.5 0.0 1.3e-06 28.6 0.0 1.8 2 0 0 2 2 2 1 RNase H RVT_1 PF00078.25 T377272_2 - 7.7e-17 61.4 0.0 1.1e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.8 T377272_2 - 1.5e-08 34.6 0.7 3.3e-08 33.5 0.7 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve PF00665.24 T377272_3 - 4.5e-08 33.2 0.0 7.9e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Transposase_22 PF02994.12 T265790_2 - 1.6e-22 79.7 2.0 2.9e-22 78.9 2.0 1.3 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T265790_3 - 3.4e-19 69.1 2.3 5.2e-19 68.5 2.3 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T103727_2 - 2.1e-142 474.2 20.5 2.8e-142 473.8 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103727_2 - 0.029 14.5 0.0 0.056 13.6 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103727_2 - 0.059 13.0 10.5 0.11 12.2 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103727_2 - 0.059 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103727_2 - 0.34 11.4 5.0 0.68 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103727_2 - 0.42 9.8 12.3 0.73 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103727_2 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103727_2 - 2.8 8.1 7.4 4.8 7.3 6.6 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Transposase_22 PF02994.12 T372558_2 - 3.8e-19 68.7 0.1 5.6e-19 68.1 0.1 1.2 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T372558_3 - 9.3e-71 238.5 25.0 1.1e-69 235.0 25.0 2.0 1 1 0 1 1 1 1 L1 transposable element Syntaxin-6_N PF09177.9 T372558_3 - 0.013 15.9 8.1 0.013 15.9 8.1 1.9 2 0 0 2 2 2 0 Syntaxin 6, N-terminal CorA PF01544.16 T372558_3 - 0.14 11.3 6.3 0.21 10.7 6.3 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF1664 PF07889.10 T372558_3 - 0.24 11.3 2.9 0.47 10.3 2.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ABC_tran_CTD PF16326.3 T372558_3 - 0.53 10.4 8.0 1.4 9.1 8.0 1.7 1 0 0 1 1 1 0 ABC transporter C-terminal domain IL28A PF15177.4 T316863_1 - 5.9 6.6 18.6 7 6.3 9.3 3.0 1 1 3 4 4 4 0 Interleukin-28A HTH_Mga PF08280.9 T316863_1 - 7 6.6 13.2 20 5.1 0.1 4.9 5 0 0 5 5 5 0 M protein trans-acting positive regulator (MGA) HTH domain GP41 PF00517.15 T280778_2 - 2.4e-19 69.8 2.6 4.4e-19 69.0 2.6 1.4 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_env_2 PF13804.4 T280778_3 - 2.1e-38 131.6 0.1 3.2e-38 131.0 0.1 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein RHSP PF07999.9 T289063_2 - 0.19 10.3 2.1 1.7 7.2 0.0 2.9 3 1 1 4 4 4 0 Retrotransposon hot spot protein HERV-K_env_2 PF13804.4 T040501_1 - 1.4e-22 80.2 0.1 2.2e-22 79.5 0.1 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GP41 PF00517.15 T040501_1 - 6.1e-07 29.3 0.0 8.9e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Retroviral envelope protein GP41 PF00517.15 T040501_2 - 2.7e-09 37.0 0.0 5e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_env_2 PF13804.4 T040501_2 - 7.5e-06 25.7 0.1 1.2e-05 25.0 0.1 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_REC PF15695.3 T040501_3 - 0.003 17.5 0.1 0.0067 16.3 0.1 1.5 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 MARVEL PF01284.21 T196637_2 - 1.7e-09 37.8 11.3 2.7e-09 37.1 11.3 1.3 1 0 0 1 1 1 1 Membrane-associating domain Lbh PF15317.4 T110892_3 - 1e-08 35.8 0.3 1.8e-08 35.0 0.3 1.3 1 0 0 1 1 1 1 Cardiac transcription factor regulator, Developmental protein Ig_3 PF13927.4 T022819_1 - 0.0014 19.0 0.3 1.9 9.0 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 T022819_1 - 0.0063 16.5 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 T022819_1 - 0.11 12.4 0.0 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin I-set domain DUF1725 PF08333.9 T016081_1 - 0.00021 20.7 0.1 0.00041 19.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T016081_3 - 8e-47 159.5 2.8 1.1e-46 159.0 2.8 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T351465_1 - 1.4e-22 80.2 1.3 2.2e-22 79.5 1.3 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T351465_1 - 3.2e-10 40.1 0.0 5.4e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T351465_1 - 1.3e-07 31.3 1.1 2.9e-07 30.2 1.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Transposase_22 PF02994.12 T351465_2 - 3.6e-151 503.0 20.2 4.9e-151 502.6 20.2 1.1 1 0 0 1 1 1 1 L1 transposable element KLRAQ PF10205.7 T351465_2 - 0.096 12.8 3.5 0.24 11.6 3.5 1.6 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Seryl_tRNA_N PF02403.20 T351465_2 - 0.18 11.9 5.7 0.31 11.1 5.7 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.12 T351465_2 - 4.3 6.9 8.5 11 5.6 8.5 1.6 1 0 0 1 1 1 0 IncA protein Collagen PF01391.16 T212066_2 - 0.064 12.9 16.3 0.2 11.3 16.3 1.8 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) CENP-B_dimeris PF09026.8 T138029_2 - 0.79 10.0 4.1 1.3 9.3 4.1 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cystatin PF00031.19 T215317_3 - 1.4e-08 34.7 0.1 2.3e-08 34.1 0.1 1.3 1 0 0 1 1 1 1 Cystatin domain DUF1725 PF08333.9 T228091_3 - 3.7e-08 32.6 0.4 7.2e-08 31.7 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Colipase-like PF15083.4 T090331_2 - 1.8e-45 152.9 26.6 5e-38 129.0 13.6 2.8 1 1 1 2 2 2 2 Colipase-like Filament PF00038.19 T078933_1 - 2e-40 139.2 14.0 2.5e-40 138.8 14.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein Spc7 PF08317.9 T078933_1 - 0.62 8.8 9.9 1.1 7.9 9.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein CALCOCO1 PF07888.9 T078933_1 - 0.64 8.4 11.7 0.85 8.0 11.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like BRE1 PF08647.9 T078933_1 - 0.64 10.0 10.1 0.86 9.6 2.9 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Tropomyosin_1 PF12718.5 T078933_1 - 4.5 7.3 12.9 7.1 6.6 12.9 1.2 1 0 0 1 1 1 0 Tropomyosin like Muted PF14942.4 T078933_1 - 7.3 6.8 10.5 11 6.2 10.5 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF1725 PF08333.9 T012470_1 - 7.9e-07 28.4 0.2 1.6e-06 27.5 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T012470_2 - 7.5e-07 28.7 3.0 2e-06 27.4 0.0 2.4 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T012470_3 - 3.7e-07 29.8 0.1 5.9e-07 29.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T253908_2 - 0.00077 18.9 1.3 0.0017 17.8 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RNA_pol_Rpc4 PF05132.12 T253908_3 - 3.7 7.9 26.8 0.12 12.7 7.5 2.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 HTH_Tnp_Tc5 PF03221.14 T136275_1 - 0.0039 17.1 0.0 0.0086 16.0 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.17 T136275_3 - 7.5e-24 84.1 0.6 2.1e-19 69.7 0.0 2.3 2 0 0 2 2 2 2 DDE superfamily endonuclease CENP-B_N PF04218.11 T136275_3 - 4.2e-07 29.4 0.9 7.7e-07 28.5 0.9 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.4 T136275_3 - 0.002 17.7 0.0 0.0049 16.5 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.4 T136275_3 - 0.0048 16.9 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain DDE_3 PF13358.4 T136275_3 - 0.02 14.5 0.0 0.086 12.5 0.0 2.0 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_38 PF13936.4 T136275_3 - 0.025 14.3 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4 PF04545.14 T136275_3 - 0.16 11.4 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 PRP38_assoc PF12871.5 T132845_3 - 2.8 8.4 16.4 5 7.6 16.4 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Plant_tran PF04827.12 T138463_3 - 0.14 11.6 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Plant transposon protein Transposase_1 PF01359.16 T355666_2 - 4.6e-18 64.7 0.2 8.7e-18 63.8 0.2 1.4 1 0 0 1 1 1 1 Transposase (partial DDE domain) SCAN PF02023.15 T005214_2 - 9.3e-19 66.9 0.5 1.6e-18 66.2 0.5 1.4 1 0 0 1 1 1 1 SCAN domain Pentapeptide PF00805.20 T138449_2 - 0.00012 21.4 0.8 0.37 10.4 0.1 4.9 5 0 0 5 5 5 1 Pentapeptide repeats (8 copies) DUF3566 PF12089.6 T107057_2 - 0.17 12.1 0.7 0.26 11.5 0.7 1.2 1 0 0 1 1 1 0 Transmembrane domain of unknown function (DUF3566) Gag_p30 PF02093.14 T252794_2 - 0.0062 15.9 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein zf-CCHC PF00098.21 T252794_3 - 8e-05 22.4 4.1 0.0002 21.1 4.1 1.8 1 0 0 1 1 1 1 Zinc knuckle DUF4641 PF15483.4 T376192_3 - 5.8e-136 454.0 13.9 7.7e-136 453.6 13.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4641) GAIN PF16489.3 T229045_3 - 0.00094 18.5 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Toxin_2 PF00451.17 T337863_2 - 5.9 7.2 8.1 0.48 10.6 1.2 2.9 2 0 0 2 2 2 0 Scorpion short toxin, BmKK2 GP41 PF00517.15 T195382_1 - 2.4e-13 50.3 5.2 4e-13 49.5 5.2 1.3 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_env_2 PF13804.4 T195382_2 - 3.3e-05 23.6 0.0 5.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_env_2 PF13804.4 T195382_3 - 8.8e-27 93.8 0.2 1.5e-26 93.0 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein CBM_19 PF03427.11 T090360_1 - 0.015 15.1 7.4 2 8.4 0.1 3.9 3 0 0 3 3 3 0 Carbohydrate binding domain (family 19) Rib PF08428.8 T182785_3 - 3.2e-06 26.9 5.2 5.7 6.9 0.0 4.7 1 1 4 5 5 5 4 Rib/alpha-like repeat NAP PF00956.16 T340385_1 - 0.0078 15.3 0.2 0.012 14.7 0.2 1.1 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Dynein_heavy PF03028.13 T085617_3 - 3.8e-11 41.8 0.0 5.6e-11 41.3 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DUF1725 PF08333.9 T345600_3 - 2e-07 30.3 0.4 7e-07 28.6 0.4 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Toxin_13 PF07822.9 T229252_2 - 0.028 14.4 0.3 0.028 14.4 0.3 2.0 2 0 0 2 2 2 0 Neurotoxin B-IV-like protein Dynein_heavy PF03028.13 T085623_3 - 4.2e-11 41.7 0.0 6e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DUF2054 PF10218.7 T353738_2 - 2.8e-05 24.1 9.7 0.00015 21.7 9.7 2.3 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2054) Transposase_22 PF02994.12 T353738_3 - 5.8e-30 104.2 3.3 8e-15 54.4 0.4 2.2 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T353738_3 - 3.5e-09 35.9 1.5 4.9e-08 32.3 0.7 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T353738_3 - 0.00074 19.0 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) IQ PF00612.25 T272774_1 - 0.0003 20.2 1.2 0.0029 17.1 0.1 2.9 2 0 0 2 2 2 1 IQ calmodulin-binding motif RVT_1 PF00078.25 T119712_2 - 3e-23 82.4 1.9 4.7e-23 81.7 1.9 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T119712_3 - 1.3e-112 376.1 20.5 2.1e-110 368.9 20.5 2.4 1 1 0 1 1 1 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T119712_3 - 2.1e-06 27.5 0.5 7.2e-06 25.7 0.5 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T119712_3 - 0.00062 19.9 0.0 0.0028 17.8 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CCDC144C PF14915.4 T018813_1 - 3.1e-30 105.2 13.6 3.1e-30 105.2 13.6 4.4 4 0 0 4 4 4 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018813_1 - 0.0031 17.4 1.1 0.0031 17.4 1.1 3.4 4 1 0 4 4 4 1 Laminin Domain II CCDC144C PF14915.4 T018813_3 - 7.4e-30 104.0 16.4 7.4e-30 104.0 16.4 2.2 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018813_3 - 1.8e-16 60.3 6.5 1.8e-16 60.3 6.5 3.4 3 1 1 4 4 4 1 Domain of unknown function (DUF3496) RVT_1 PF00078.25 T375366_1 - 1.7e-12 47.2 0.0 2.5e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T375366_2 - 6.6e-22 78.1 0.0 1.2e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-H2C2 PF09337.8 T375366_2 - 5.4e-05 23.2 0.0 0.00013 22.1 0.0 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RS4NT PF08071.10 T194249_2 - 5.4 7.1 26.3 44 4.2 0.1 8.3 9 0 0 9 9 9 0 RS4NT (NUC023) domain Transposase_1 PF01359.16 T274863_3 - 2.4e-21 75.3 0.2 6e-21 74.0 0.2 1.7 1 0 0 1 1 1 1 Transposase (partial DDE domain) HTH_Tnp_IS630 PF01710.14 T274863_3 - 0.11 12.5 0.4 0.19 11.7 0.4 1.3 1 0 0 1 1 1 0 Transposase BAR_3_WASP_bdg PF10456.7 T018836_1 - 8e-14 51.5 0.3 8e-13 48.3 0.1 2.1 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein BAR_3_WASP_bdg PF10456.7 T018836_2 - 3.4e-16 59.3 1.1 1.8e-08 34.1 0.4 2.1 2 0 0 2 2 2 2 WASP-binding domain of Sorting nexin protein Gag_p30 PF02093.14 T065982_1 - 6.3e-16 58.4 0.0 9.7e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T065982_1 - 0.098 12.8 0.0 0.88 9.7 0.0 2.1 2 0 0 2 2 2 0 Retroviral aspartyl protease RNase_H PF00075.22 T065982_2 - 4e-17 62.6 0.0 7.1e-17 61.8 0.0 1.3 1 0 0 1 1 1 1 RNase H rve PF00665.24 T065982_2 - 1.6e-05 25.0 0.0 2.7e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T065982_2 - 0.026 13.9 0.1 0.073 12.4 0.1 1.7 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T065982_3 - 0.00028 20.3 0.0 0.00044 19.7 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Transposase_22 PF02994.12 T111720_1 - 0.0012 17.6 3.8 0.0014 17.4 2.2 1.7 2 0 0 2 2 2 1 L1 transposable element Sec8_exocyst PF04048.12 T111720_3 - 0.11 12.2 1.6 0.18 11.6 1.6 1.2 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Transposase_1 PF01359.16 T021186_1 - 4.2e-05 23.2 0.0 7.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T021186_2 - 4e-23 81.0 1.6 6.8e-23 80.2 1.6 1.4 1 0 0 1 1 1 1 Transposase (partial DDE domain) Pox_Ag35 PF03286.12 T021186_2 - 0.12 12.0 0.6 0.2 11.3 0.6 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RNA_pol_Rpc4 PF05132.12 T344692_1 - 0.11 12.8 11.8 0.25 11.6 11.8 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.15 T344692_1 - 0.28 9.8 17.2 0.45 9.1 17.2 1.2 1 0 0 1 1 1 0 Presenilin MIP-T3 PF10243.7 T344692_1 - 0.96 8.0 54.7 1.3 7.6 54.7 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 SAPS PF04499.13 T344692_1 - 2.7 6.5 9.0 3.9 6.0 9.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DDHD PF02862.15 T344692_1 - 7.2 6.5 13.7 11 5.9 13.7 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.15 T344692_3 - 0.19 10.3 18.0 0.27 9.8 18.0 1.1 1 0 0 1 1 1 0 Presenilin Transposase_22 PF02994.12 T344807_2 - 1.4e-123 412.3 15.8 1.4e-123 412.3 15.8 1.9 2 0 0 2 2 2 1 L1 transposable element RVT_1 PF00078.25 T344807_2 - 3.4e-38 131.2 1.5 6e-38 130.4 1.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T344807_2 - 0.0002 21.5 0.0 0.00041 20.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family KLRAQ PF10205.7 T344807_2 - 0.074 13.2 3.8 0.18 11.9 3.8 1.6 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Seryl_tRNA_N PF02403.20 T344807_2 - 0.17 12.0 2.5 0.33 11.1 2.5 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.9 T344807_2 - 1.1 9.8 5.4 0.61 10.6 2.5 2.0 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Transposase_22 PF02994.12 T344807_3 - 6.3e-19 67.9 4.7 9.3e-19 67.4 4.7 1.1 1 0 0 1 1 1 1 L1 transposable element FAM27 PF15832.3 T222616_1 - 0.012 16.0 11.1 0.012 16.0 11.1 10.9 5 4 2 7 7 7 0 FAM27 D and E protein family DUF3915 PF13054.4 T222616_1 - 0.35 10.7 9.8 0.67 9.8 9.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 T222616_2 - 0.00037 20.8 14.1 0.00037 20.8 14.1 11.9 4 3 3 8 8 8 1 FAM27 D and E protein family DUF3915 PF13054.4 T222616_2 - 0.77 9.6 10.0 1.6 8.6 10.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 T222616_3 - 0.0087 16.5 9.9 0.0087 16.5 9.9 12.1 4 3 3 7 7 7 1 FAM27 D and E protein family Eapp_C PF10238.7 T068777_3 - 0.054 13.5 3.7 0.12 12.3 3.7 1.6 1 0 0 1 1 1 0 E2F-associated phosphoprotein Coilin_N PF15862.3 T068777_3 - 0.067 12.8 15.5 0.11 12.2 15.5 1.3 1 0 0 1 1 1 0 Coilin N-terminus RR_TM4-6 PF06459.10 T068777_3 - 0.2 11.3 15.3 0.31 10.7 15.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.15 T068777_3 - 0.28 11.1 2.0 0.45 10.5 2.0 1.2 1 0 0 1 1 1 0 DDHD domain NARP1 PF12569.6 T068777_3 - 0.71 8.5 20.0 0.98 8.1 20.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Rrn6 PF10214.7 T068777_3 - 1.7 6.8 9.8 2.6 6.2 9.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1510 PF07423.9 T068777_3 - 2.7 7.2 16.5 4.4 6.6 16.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CCDC71L PF15374.4 T068777_3 - 3.1 6.8 12.6 4.6 6.3 12.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L SpoIIP PF07454.9 T068777_3 - 5.1 6.3 8.8 8.4 5.6 8.8 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FLO_LFY PF01698.14 T068777_3 - 5.1 6.1 10.0 7.8 5.5 10.0 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Tim54 PF11711.6 T068777_3 - 5.2 5.6 14.1 7.6 5.1 14.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AAA_11 PF13086.4 T068777_3 - 5.2 6.6 10.7 8 6.0 10.7 1.1 1 0 0 1 1 1 0 AAA domain Sec62 PF03839.14 T068777_3 - 6.7 6.0 17.8 11 5.3 17.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 AT_hook PF02178.17 T156299_1 - 0.36 10.7 2.3 9.3 6.4 0.1 3.2 2 0 0 2 2 2 0 AT hook motif zf-CCHC_5 PF14787.4 T167928_1 - 1.5e-16 59.7 1.3 3.5e-16 58.5 1.3 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Gag_p24 PF00607.18 T167928_1 - 0.00018 21.3 0.0 0.00029 20.7 0.0 1.1 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) Gag_p24 PF00607.18 T167928_2 - 2.5e-29 102.5 0.0 2.8e-24 86.0 0.0 2.3 2 0 0 2 2 2 2 gag gene protein p24 (core nucleocapsid protein) Gag_p10 PF02337.15 T167928_2 - 2.7e-06 27.0 0.1 6.6e-06 25.8 0.1 1.7 1 0 0 1 1 1 1 Retroviral GAG p10 protein HERV-K_REC PF15695.3 T167928_2 - 0.012 15.5 0.1 0.034 14.1 0.1 1.7 1 0 0 1 1 1 0 Rec (regulator of expression encoded by corf) of HERV-K-113 Gag_p10 PF02337.15 T167928_3 - 6.1e-05 22.7 0.0 0.0001 21.9 0.0 1.3 1 0 0 1 1 1 1 Retroviral GAG p10 protein DUF3439 PF11921.6 T364253_1 - 0.0073 16.1 4.2 0.012 15.4 4.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) DUF2256 PF10013.7 T364253_1 - 0.1 12.6 0.3 0.29 11.1 0.3 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) Pep_M12B_propep PF01562.17 T106643_1 - 1.7e-16 60.6 0.0 4.2e-16 59.3 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.17 T106643_1 - 5e-15 55.8 0.5 7.7e-15 55.2 0.5 1.2 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 T106643_1 - 0.0057 16.7 0.8 0.0097 15.9 0.8 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T106643_1 - 0.0064 16.9 0.2 0.011 16.1 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T106643_1 - 0.14 11.7 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like ADAM_CR PF08516.10 T106643_3 - 2e-21 76.4 2.8 2e-21 76.4 2.8 3.6 3 1 1 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.21 T106643_3 - 2.5e-16 60.1 26.2 2.5e-16 60.1 26.2 3.2 3 0 0 3 3 3 1 Disintegrin DUF4705 PF15788.3 T322048_1 - 8.2e-26 89.8 80.0 1.9e-14 53.4 12.6 20.5 7 4 12 19 19 19 9 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322048_2 - 1e-49 166.4 242.5 2.4e-18 65.9 10.8 20.3 10 5 8 19 19 19 16 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322048_3 - 1.8e-06 27.9 220.3 0.003 17.6 6.0 20.7 15 4 3 18 18 18 11 Domain of unknown function (DUF4705) RVT_1 PF00078.25 T268137_1 - 1.3e-22 80.3 0.0 1.9e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T268137_1 - 8.3e-11 42.1 0.0 1.7e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 RNase H zf-H2C2 PF09337.8 T268137_3 - 3.4e-07 30.3 0.2 7.6e-07 29.2 0.2 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RVT_1 PF00078.25 T161809_1 - 9.8e-18 64.3 0.1 1.5e-17 63.8 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T161809_1 - 2.6e-08 33.2 0.8 5.8e-08 32.0 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T161809_3 - 2.1e-19 69.8 0.2 3.4e-19 69.1 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T065987_1 - 3.9e-17 62.7 0.0 6.8e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 RNase H rve PF00665.24 T065987_1 - 1.5e-05 25.0 0.0 2.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T065987_1 - 0.024 14.0 0.1 0.072 12.5 0.1 1.7 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T065987_2 - 0.00027 20.4 0.0 0.00043 19.7 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p30 PF02093.14 T065987_3 - 6.1e-16 58.5 0.0 9.4e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T065987_3 - 0.092 12.9 0.0 0.85 9.8 0.0 2.2 2 0 0 2 2 2 0 Retroviral aspartyl protease Forkhead PF00250.16 T221440_1 - 0.0047 17.1 0.1 0.01 16.0 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain CBM_26 PF16824.3 T221440_1 - 0.062 13.3 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 C-terminal carbohydrate-binding module DUF1725 PF08333.9 T334440_1 - 0.00014 21.3 1.9 0.00034 20.0 1.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) EPF PF17181.2 T317089_2 - 0.018 14.9 6.4 0.097 12.5 6.4 2.4 1 0 0 1 1 1 0 Epidermal patterning factor proteins DUF1725 PF08333.9 T183291_2 - 0.008 15.7 0.8 0.019 14.5 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1725 PF08333.9 T353113_2 - 0.0032 16.9 0.3 0.0074 15.8 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) zf-MIZ PF02891.18 T235925_3 - 0.11 12.1 0.1 0.11 12.1 0.1 1.9 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Gag_p30 PF02093.14 T084008_1 - 0.01 15.2 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein TLV_coat PF00429.17 T084008_3 - 3.1e-44 151.5 4.0 3.1e-44 151.5 4.0 1.6 2 0 0 2 2 2 1 ENV polyprotein (coat polyprotein) RNase_H PF00075.22 T084008_3 - 4e-18 65.9 0.0 7.7e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T084008_3 - 4.1e-16 59.0 0.4 1.1e-15 57.6 0.0 1.9 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T084008_3 - 4.4e-16 58.9 0.0 7.9e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T084008_3 - 7.5e-09 35.7 0.0 1.6e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T084008_3 - 1.3e-05 25.3 0.0 2.6e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T324470_1 - 0.00014 21.3 0.1 0.00025 20.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.4 T324470_1 - 0.09 12.2 0.4 0.15 11.5 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) RVT_1 PF00078.25 T324470_2 - 2e-26 92.7 2.1 3.2e-26 92.1 2.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T324470_2 - 3.3e-08 32.8 0.8 6.6e-08 31.9 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Ribosomal_L27A PF00828.17 T125652_2 - 1.5e-05 25.5 0.0 2.3e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF913 PF06025.10 T251535_1 - 6.6 5.5 8.1 12 4.5 8.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SDA1 PF05285.10 T251535_3 - 0.0018 17.7 56.1 0.0018 17.7 56.1 1.7 2 0 0 2 2 2 1 SDA1 DUF3809 PF12723.5 T182956_3 - 0.027 14.6 0.2 3.2e+02 1.4 0.0 5.7 3 3 5 8 8 8 0 Protein of unknown function (DUF3809) DUF781 PF05612.10 T311164_3 - 1.1e-06 27.9 0.0 1.6e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Mouse protein of unknown function (DUF781) GP41 PF00517.15 T034734_1 - 9.6e-22 77.7 0.2 1.6e-21 76.9 0.2 1.3 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_REC PF15695.3 T034734_1 - 1.6e-09 37.5 2.3 3.4e-09 36.5 2.3 1.5 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 PspB PF06667.10 T034734_1 - 0.012 15.6 0.0 0.24 11.3 0.1 2.7 2 0 0 2 2 2 0 Phage shock protein B HERV-K_env_2 PF13804.4 T034734_2 - 4.2e-16 59.0 0.0 6.6e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_env_2 PF13804.4 T034734_3 - 4.5e-09 36.1 0.0 7.1e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Homeobox PF00046.27 T379416_3 - 0.014 15.1 0.0 0.045 13.5 0.0 1.8 2 0 0 2 2 2 0 Homeobox domain Toxin_18 PF08087.9 T099561_1 - 0.45 10.4 5.8 3.9 7.4 2.1 3.5 2 0 0 2 2 2 0 Conotoxin O-superfamily rve PF00665.24 T126996_1 - 9.2e-23 80.6 0.0 3.7e-11 43.1 0.0 2.3 2 0 0 2 2 2 2 Integrase core domain TLV_coat PF00429.17 T126996_1 - 1.8e-19 69.7 10.4 1.3e-14 53.7 3.2 2.4 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) RVT_1 PF00078.25 T126996_1 - 1.9e-17 63.4 0.0 6.3e-17 61.7 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.18 T126996_1 - 9.6e-10 38.5 0.0 2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.21 T126996_1 - 0.00036 20.3 1.8 0.00092 19.1 1.8 1.8 1 0 0 1 1 1 1 Zinc knuckle rve_3 PF13683.4 T126996_1 - 0.026 14.2 0.0 0.85 9.3 0.0 2.4 2 0 0 2 2 2 0 Integrase core domain TLV_coat PF00429.17 T126996_2 - 2.4e-20 72.6 0.1 4.1e-20 71.8 0.1 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RVT_1 PF00078.25 T126996_2 - 0.0061 16.0 0.0 0.0094 15.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T126996_2 - 0.0065 15.9 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T126996_3 - 2.6e-07 30.7 0.0 4.3e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease HTH_24 PF13412.4 T269666_1 - 0.059 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Transposase_1 PF01359.16 T269666_2 - 5.9e-19 67.6 0.0 1.4e-18 66.3 0.0 1.7 1 0 0 1 1 1 1 Transposase (partial DDE domain) HERV-K_REC PF15695.3 T076799_1 - 9.9e-05 22.2 0.5 0.00016 21.5 0.5 1.3 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 PseudoU_synth_1 PF01416.18 T076799_1 - 0.0072 16.6 0.0 5.4 7.4 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase ODC_AZ PF02100.15 T076799_1 - 0.083 12.8 0.0 14 5.5 0.0 2.3 2 0 0 2 2 2 0 Ornithine decarboxylase antizyme DPM3 PF08285.9 T076799_2 - 0.43 10.6 2.7 12 6.0 0.3 2.1 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Yae1_N PF09811.7 T351471_1 - 2 8.1 6.1 3.6 7.2 6.1 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal TLV_coat PF00429.17 T351471_2 - 8.4e-25 87.3 2.8 8.4e-25 87.3 2.8 2.4 2 0 0 2 2 2 1 ENV polyprotein (coat polyprotein) Coilin_N PF15862.3 T351471_3 - 0.00018 21.2 5.9 0.00018 21.2 5.9 3.0 3 0 0 3 3 3 1 Coilin N-terminus RVP PF00077.18 T351471_3 - 0.0036 17.4 0.0 0.0063 16.6 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Exo_endo_phos PF03372.21 T327326_1 - 0.0037 17.4 0.0 0.009 16.1 0.0 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T327326_2 - 2e-30 105.8 9.6 1.7e-28 99.4 1.9 2.4 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T327326_3 - 2.1e-52 177.7 1.5 3.9e-52 176.8 1.5 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T327326_3 - 1e-34 119.9 2.7 1.4e-20 73.4 0.8 2.5 2 0 0 2 2 2 2 L1 transposable element rve PF00665.24 T045386_1 - 2.2e-14 53.5 0.0 3.5e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.4 T045386_1 - 0.0059 16.2 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T045386_1 - 0.12 12.5 0.2 0.22 11.6 0.2 1.4 1 0 0 1 1 1 0 RNase H dUTPase PF00692.17 T045386_2 - 1.1e-06 28.2 0.0 1.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 dUTPase Transposase_22 PF02994.12 T111737_1 - 0.00036 19.4 3.7 0.00069 18.4 2.2 1.8 2 0 0 2 2 2 1 L1 transposable element Sec8_exocyst PF04048.12 T111737_3 - 0.054 13.3 1.6 0.084 12.6 1.6 1.2 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain VCX_VCY PF15231.4 T381761_2 - 1.6e-06 28.7 0.1 2e-06 28.4 0.1 1.1 1 0 0 1 1 1 1 Variable charge X/Y family Colipase-like PF15083.4 T090340_1 - 1.8e-31 108.0 13.5 3.2e-31 107.2 13.5 1.4 1 0 0 1 1 1 1 Colipase-like Colipase-like PF15083.4 T090340_3 - 1.4e-10 41.1 5.5 3e-10 40.0 5.5 1.5 1 0 0 1 1 1 1 Colipase-like MdoG PF04349.10 T125879_3 - 0.043 12.6 0.4 0.059 12.2 0.4 1.1 1 0 0 1 1 1 0 Periplasmic glucan biosynthesis protein, MdoG DUF4705 PF15788.3 T323242_1 - 0.024 14.7 20.1 1.2 9.3 4.3 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323242_2 - 0.00023 21.2 6.4 0.00023 21.2 6.4 6.4 6 1 1 7 7 7 2 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323242_3 - 0.014 15.5 6.8 0.014 15.5 6.8 6.0 5 1 0 5 5 5 0 Domain of unknown function (DUF4705) AMP-binding PF00501.26 T228737_3 - 2.7e-05 22.8 0.0 3.8e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme MIP-T3 PF10243.7 T228737_3 - 0.74 8.3 9.7 1.2 7.6 9.7 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 BAR_3_WASP_bdg PF10456.7 T018779_2 - 4.1e-13 49.2 0.4 1.8e-12 47.1 0.1 1.8 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein BAR_3_WASP_bdg PF10456.7 T018779_3 - 2.1e-16 60.0 0.9 1.6e-08 34.2 0.3 2.3 2 0 0 2 2 2 2 WASP-binding domain of Sorting nexin protein UBZ_FAAP20 PF15750.3 T138407_3 - 0.22 11.4 3.2 0.15 11.9 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger Ada_Zn_binding PF02805.14 T035719_1 - 0.00015 21.6 3.0 22 5.1 0.1 5.1 2 2 3 5 5 5 4 Metal binding domain of Ada APP_Cu_bd PF12924.5 T035719_1 - 8.7 7.1 12.1 69 4.2 0.0 4.9 6 0 0 6 6 6 0 Copper-binding of amyloid precursor, CuBD Ada_Zn_binding PF02805.14 T035719_2 - 0.03 14.2 2.4 64 3.5 0.0 4.9 3 2 3 6 6 6 0 Metal binding domain of Ada YjbT PF17089.3 T035719_2 - 0.47 10.4 3.0 2.3 8.2 0.1 3.1 3 1 1 4 4 4 0 Uncharacterised protein family Flu_C_NS2 PF03555.12 T155283_1 - 0.093 12.8 3.3 2.4 8.2 0.6 2.7 2 0 0 2 2 2 0 Influenza C non-structural protein (NS2) DUF4408 PF14364.4 T155283_2 - 0.0081 15.7 0.0 0.48 10.1 0.0 4.0 7 0 0 7 7 7 1 Domain of unknown function (DUF4408) DUF3237 PF11578.6 T155283_2 - 5.7 6.6 11.1 13 5.5 1.4 3.9 1 1 3 4 4 4 0 Protein of unknown function (DUF3237) KxDL PF10241.7 T004143_2 - 7.2 6.8 14.8 0.33 11.1 7.4 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein Tetraspannin PF00335.18 T316994_1 - 0.078 12.7 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Tetraspanin family V_ATPase_I PF01496.17 T316994_3 - 5.1 4.7 15.4 7.2 4.2 15.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RNase_H PF00075.22 T039847_1 - 5.7e-20 71.8 0.0 1e-19 71.0 0.0 1.3 1 0 0 1 1 1 1 RNase H rve PF00665.24 T039847_1 - 4.7e-10 39.6 0.0 8.7e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T039847_1 - 1.4e-06 28.3 0.4 3e-06 27.3 0.4 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Gag_p30 PF02093.14 T039847_2 - 1.5e-49 168.2 0.6 2.4e-49 167.6 0.6 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_MA PF01140.17 T039847_2 - 8.4e-17 60.9 0.1 1.8e-16 59.9 0.1 1.5 1 0 0 1 1 1 1 Matrix protein (MA), p15 RVT_1 PF00078.25 T039847_3 - 6.3e-23 81.3 0.0 1.1e-22 80.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.18 T039847_3 - 8.5e-13 48.3 0.0 1.4e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_1 PF00078.25 T261116_3 - 6.5e-11 42.0 0.0 9.7e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T325351_2 - 1.6e-19 70.2 0.8 4.6e-13 49.0 0.1 2.2 2 0 0 2 2 2 2 Gag P30 core shell protein RVT_1 PF00078.25 T325351_3 - 1.9e-15 56.9 0.0 6.3e-15 55.2 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T325351_3 - 0.0048 16.3 0.2 0.0081 15.6 0.2 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein Rhodanese PF00581.18 T308580_3 - 0.00027 21.3 0.1 0.00046 20.5 0.1 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Wbp11 PF09429.8 T308580_3 - 4.5 7.6 12.0 8.3 6.7 12.0 1.3 1 0 0 1 1 1 0 WW domain binding protein 11 fn3 PF00041.19 T069804_3 - 5.4e-07 29.7 0.0 8.9e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Ig_2 PF13895.4 T069804_3 - 0.015 15.5 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.4 T069804_3 - 0.028 14.9 0.1 0.085 13.4 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin domain RVT_1 PF00078.25 T091122_2 - 1.6e-07 30.9 0.0 2.6e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T292099_2 - 5.5e-43 146.9 2.3 8.3e-43 146.3 2.3 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Bradykinin PF06753.10 T211930_2 - 3 7.5 9.1 2.1 8.0 2.6 3.1 2 0 0 2 2 2 0 Bradykinin DUF4641 PF15483.4 T376186_1 - 6.6e-176 585.7 18.5 6.6e-176 585.7 18.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4641) zf-BED PF02892.13 T060457_2 - 0.00023 21.0 0.4 0.49 10.4 0.1 3.3 3 0 0 3 3 3 2 BED zinc finger DUF678 PF05077.10 T060457_2 - 0.29 11.2 0.8 44 4.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF678) DUF1964 PF09244.8 T228066_2 - 0.054 13.8 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1964) AMP-binding PF00501.26 T228728_3 - 2.3e-05 23.0 0.0 3.3e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme MIP-T3 PF10243.7 T228728_3 - 0.67 8.5 9.7 1.1 7.8 9.7 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Transposase_22 PF02994.12 T044443_1 - 2.8e-37 128.3 1.4 2.8e-37 128.3 1.4 2.7 3 0 0 3 3 3 1 L1 transposable element Exo_endo_phos PF03372.21 T044443_2 - 0.0029 17.7 0.0 0.0056 16.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.25 T044443_3 - 3.6e-37 127.9 5.7 6.3e-37 127.1 5.7 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.4 T044443_3 - 0.0031 17.2 2.6 0.0063 16.2 2.6 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase PHO4 PF01384.18 T236008_3 - 8.6e-06 24.9 0.3 0.0018 17.3 0.0 2.4 2 0 0 2 2 2 2 Phosphate transporter family MscS_porin PF12795.5 T170373_1 - 3.4 7.0 7.3 5.6 6.3 7.3 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain IncA PF04156.12 T170373_2 - 0.12 12.0 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 IncA protein SSP160 PF06933.9 T111409_1 - 0.99 7.4 22.9 1.5 6.8 22.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RBP_receptor PF14752.4 T358364_2 - 9.2e-40 136.7 1.7 1.3e-39 136.2 1.7 1.1 1 0 0 1 1 1 1 Retinol binding protein receptor DUF3496 PF12001.6 T018731_1 - 1.1e-09 38.5 0.1 1.1e-09 38.5 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3496) DUF4795 PF16043.3 T018731_1 - 0.0027 17.2 4.5 0.0027 17.2 4.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4795) IncA PF04156.12 T018731_1 - 4.1 7.0 10.7 6.7 6.3 10.7 1.3 1 0 0 1 1 1 0 IncA protein HTH_Tnp_Tc5 PF03221.14 T371834_1 - 0.0087 15.9 0.1 0.023 14.6 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.17 T371834_3 - 3.1e-37 127.7 0.4 4.4e-37 127.2 0.4 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DMAP1_like PF17024.3 T371834_3 - 0.055 13.5 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Putative DMAP1-like DUF1028 PF06267.10 T258975_3 - 5 6.7 6.6 9.5 5.8 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) Histone_H2A_C PF16211.3 T316340_3 - 1.9e-15 56.1 38.0 0.072 12.7 0.2 11.4 1 1 12 13 13 13 13 C-terminus of histone H2A Pentapeptide_4 PF13599.4 T040460_1 - 9.1e-11 41.6 5.4 2.4 8.2 0.0 8.9 7 2 4 11 11 11 6 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T040460_2 - 2.9e-17 62.4 7.0 0.002 18.1 1.2 8.4 8 1 1 9 9 9 6 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T040460_3 - 2.2e-15 56.4 16.0 0.051 13.6 0.0 10.9 4 2 4 9 9 9 8 Pentapeptide repeats (9 copies) Gag_MA PF01140.17 T324099_2 - 0.00023 20.7 0.0 0.00041 19.9 0.0 1.3 1 0 0 1 1 1 1 Matrix protein (MA), p15 Gag_p30 PF02093.14 T324099_2 - 0.0019 17.6 0.0 0.0027 17.1 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein DUF1582 PF07621.9 T001381_1 - 0.35 10.7 3.0 2.2 8.1 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1582) PT PF04886.10 T036649_1 - 0.00049 19.5 11.0 0.089 12.2 0.1 3.9 4 0 0 4 4 4 2 PT repeat PT PF04886.10 T036649_2 - 2.2 7.8 15.5 25 4.4 0.1 4.7 3 2 0 3 3 3 0 PT repeat RNase_H PF00075.22 T037987_3 - 0.035 14.2 0.0 0.048 13.7 0.0 1.2 1 0 0 1 1 1 0 RNase H Gallidermin PF02052.13 T100207_3 - 0.027 14.6 0.0 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 Gallidermin DUF1725 PF08333.9 T095162_1 - 0.13 11.9 2.6 0.25 10.9 2.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Presenilin PF01080.15 T095162_1 - 0.32 9.6 12.4 0.53 8.8 12.4 1.3 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.11 T095162_3 - 0.12 11.0 22.8 0.16 10.6 22.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MCM_bind PF09739.7 T095162_3 - 0.18 10.1 17.2 0.24 9.7 17.2 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Pap_E4 PF02711.12 T095162_3 - 0.25 12.3 2.6 0.43 11.5 2.6 1.4 1 0 0 1 1 1 0 E4 protein DUF1510 PF07423.9 T095162_3 - 0.51 9.6 31.3 0.7 9.2 31.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4746 PF15928.3 T095162_3 - 0.62 9.3 24.8 0.85 8.8 24.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RR_TM4-6 PF06459.10 T095162_3 - 2.1 8.0 26.2 3 7.5 26.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.17 T095162_3 - 3.2 5.4 16.3 4.2 5.0 16.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF913 PF06025.10 T095162_3 - 3.8 6.2 10.7 4.8 5.9 10.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.15 T095162_3 - 4 6.0 21.0 5.3 5.5 21.0 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.20 T095162_3 - 5 6.1 14.5 6.8 5.7 14.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DDHD PF02862.15 T095162_3 - 5.4 6.9 13.7 6.9 6.6 13.7 1.1 1 0 0 1 1 1 0 DDHD domain CLN3 PF02487.15 T095162_3 - 8.7 5.1 7.5 13 4.6 7.5 1.3 1 0 0 1 1 1 0 CLN3 protein CCDC144C PF14915.4 T018738_2 - 5.5e-61 206.2 57.3 5.3e-36 124.2 14.1 3.3 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018738_2 - 5.3e-09 36.3 0.1 5.3e-09 36.3 0.1 4.3 4 0 0 4 4 4 1 Domain of unknown function (DUF3496) Laminin_II PF06009.10 T018738_2 - 0.009 15.9 1.1 0.009 15.9 1.1 2.9 3 0 0 3 3 3 1 Laminin Domain II CCDC144C PF14915.4 T018738_3 - 8.6e-17 61.1 9.6 8.6e-17 61.1 9.6 1.5 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region Mucin-like PF16058.3 T259460_1 - 3.1e-08 33.5 35.5 5.1e-06 26.4 10.2 8.0 1 1 7 8 8 8 6 Mucin-like CTD PF12815.5 T259460_2 - 2.3e-20 72.8 70.8 4.1e-07 30.3 16.0 5.7 3 1 3 6 6 6 6 Spt5 C-terminal nonapeptide repeat binding Spt4 Mucin-like PF16058.3 T259460_2 - 0.00092 19.1 17.9 0.00092 19.1 17.9 9.8 2 1 6 9 9 9 3 Mucin-like CTD PF12815.5 T259460_3 - 1.8e-23 82.8 84.9 6.4e-07 29.7 17.6 5.9 3 2 2 5 5 5 4 Spt5 C-terminal nonapeptide repeat binding Spt4 zf-CCHC PF00098.21 T070081_2 - 2.2e-05 24.2 3.9 2.2e-05 24.2 3.9 2.7 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.4 T070081_2 - 3.1 7.5 13.4 3.1 7.4 2.8 2.7 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Gag_p30 PF02093.14 T070081_3 - 0.00059 19.3 0.0 0.00099 18.5 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Transposase_22 PF02994.12 T100325_1 - 4.9e-74 249.3 13.5 6.9e-74 248.8 13.5 1.1 1 0 0 1 1 1 1 L1 transposable element Syntaxin-6_N PF09177.9 T100325_1 - 0.0079 16.6 4.9 0.016 15.6 4.9 1.4 1 0 0 1 1 1 1 Syntaxin 6, N-terminal KLRAQ PF10205.7 T100325_1 - 0.036 14.2 5.3 0.074 13.2 5.3 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Tropomyosin_1 PF12718.5 T100325_1 - 0.05 13.6 10.3 0.083 12.9 10.3 1.3 1 0 0 1 1 1 0 Tropomyosin like DUF1465 PF07323.10 T100325_1 - 0.11 12.3 0.9 0.18 11.5 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) Seryl_tRNA_N PF02403.20 T100325_1 - 0.11 12.5 3.8 0.21 11.7 3.8 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain SKA2 PF16740.3 T100325_1 - 0.74 9.5 4.6 1.5 8.5 4.6 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Transposase_22 PF02994.12 T100325_3 - 1e-17 64.0 5.4 1.5e-17 63.4 5.4 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T100325_3 - 7e-08 32.1 2.1 1.1e-06 28.2 0.7 2.2 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T103189_1 - 8e-06 25.6 2.6 1.5e-05 24.7 2.6 1.5 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.18 T103189_1 - 0.0049 17.0 0.0 0.0085 16.2 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_5 PF14787.4 T103189_1 - 0.27 10.8 3.9 0.58 9.8 3.9 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Gag_p30 PF02093.14 T103189_2 - 0.0032 16.9 0.0 0.0054 16.2 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein DUF1725 PF08333.9 T184413_1 - 0.54 9.9 2.5 0.96 9.1 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Tektin PF03148.12 T383220_1 - 6e-62 209.5 20.1 3.2e-26 91.8 3.3 4.1 4 0 0 4 4 4 4 Tektin family Tektin PF03148.12 T383220_2 - 1.5e-17 63.3 0.0 1.8e-10 40.0 0.1 2.1 2 0 0 2 2 2 2 Tektin family ATG16 PF08614.9 T383220_2 - 0.16 12.0 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Orn_DAP_Arg_deC PF00278.20 T007017_1 - 7.3e-11 42.0 0.0 1.3e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Orn_Arg_deC_N PF02784.14 T007017_2 - 1.2e-05 24.8 0.0 1.9e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain DUF4641 PF15483.4 T376183_1 - 2e-175 584.1 18.5 2e-175 584.1 18.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4641) HERV-K_env_2 PF13804.4 T192682_2 - 1.6e-46 158.0 0.4 2.5e-46 157.4 0.4 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GP41 PF00517.15 T192682_2 - 4.2e-17 62.5 3.0 8.1e-17 61.6 3.0 1.3 1 0 0 1 1 1 1 Retroviral envelope protein IN_DBD_C PF00552.19 T192682_2 - 0.0017 17.5 0.1 0.0036 16.4 0.1 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain HERV-K_REC PF15695.3 T192682_2 - 0.038 13.9 0.3 0.076 12.9 0.3 1.4 1 0 0 1 1 1 0 Rec (regulator of expression encoded by corf) of HERV-K-113 Transposase_22 PF02994.12 T303383_1 - 4.5e-31 107.9 1.8 2.4e-18 66.0 0.0 2.2 2 0 0 2 2 2 2 L1 transposable element Transposase_22 PF02994.12 T303383_2 - 5.9e-25 87.8 14.4 1.9e-19 69.6 0.1 4.0 3 1 0 3 3 3 2 L1 transposable element RVT_1 PF00078.25 T303383_3 - 1.9e-14 53.6 0.1 3.4e-14 52.8 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T303383_3 - 3.7e-13 49.0 1.7 4.2e-08 32.3 0.0 2.5 3 0 0 3 3 3 2 L1 transposable element KRTAP PF11759.6 T004510_2 - 1.4 9.4 49.3 1.6e+04 -6.5 49.3 2.7 1 1 0 1 1 1 0 Keratin-associated matrix Integrin_alpha PF00357.18 T136058_1 - 2.4 8.2 6.4 1.1 9.2 0.6 2.7 2 0 0 2 2 2 0 Integrin alpha cytoplasmic region Hexapep PF00132.22 T100165_2 - 7e-06 25.4 2.0 0.037 13.6 0.0 4.6 6 0 0 6 6 6 3 Bacterial transferase hexapeptide (six repeats) SoxG PF04268.10 T173077_1 - 0.042 13.9 0.1 0.063 13.3 0.1 1.3 1 0 0 1 1 1 0 Sarcosine oxidase, gamma subunit family RVT_1 PF00078.25 T091123_3 - 1.5e-07 31.0 0.0 2.4e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RnaseA PF00074.18 T100531_1 - 2e-05 25.0 2.9 4.1e-05 23.9 2.9 1.4 1 0 0 1 1 1 1 Pancreatic ribonuclease RnaseA PF00074.18 T100531_2 - 0.00014 22.2 0.0 0.00028 21.2 0.0 1.5 1 0 0 1 1 1 1 Pancreatic ribonuclease RVP PF00077.18 T228570_2 - 6.3e-05 23.1 0.0 0.0001 22.4 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease CCDC154 PF15450.4 T229997_1 - 0.0077 14.8 9.3 0.011 14.3 9.3 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 154 GAS PF13851.4 T229997_1 - 1 8.5 17.7 1.5 8.0 17.7 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.9 T229997_1 - 1.3 7.7 14.8 1.8 7.2 14.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.7 T229997_1 - 2.4 8.4 4.8 3.1 8.0 0.9 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Exonuc_VII_L PF02601.13 T229997_1 - 3.3 7.1 9.2 4.7 6.5 9.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Syntaxin-6_N PF09177.9 T229997_1 - 4.8 7.7 9.3 7.6 7.0 7.6 1.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF883 PF05957.11 T229997_1 - 5 7.6 9.8 9.4 6.8 9.8 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) IncA PF04156.12 T229997_1 - 6.4 6.4 18.7 13 5.4 18.7 1.4 1 0 0 1 1 1 0 IncA protein TMEM191C PF15194.4 T229997_3 - 1.1e-47 160.9 5.5 1.9e-47 160.2 5.5 1.3 1 0 0 1 1 1 1 TMEM191C family Med28 PF11594.6 T227654_2 - 0.0036 17.2 6.1 23 4.9 0.1 5.9 3 2 3 6 6 6 2 Mediator complex subunit 28 SEA PF01390.18 T119771_1 - 0.0002 21.4 0.0 0.075 13.2 0.0 2.2 2 0 0 2 2 2 2 SEA domain Gag_p30 PF02093.14 T226508_1 - 3.8e-12 46.1 0.0 5.6e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein rve PF00665.24 T226508_1 - 0.13 12.4 0.1 0.24 11.5 0.1 1.3 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.25 T226508_2 - 0.085 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T226508_3 - 0.00016 21.1 0.6 0.00016 21.1 0.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T346962_1 - 5.1e-25 88.2 5.1 3e-24 85.7 5.1 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4705 PF15788.3 T322059_1 - 3.2e-05 23.9 224.2 0.003 17.6 6.0 21.0 16 4 3 19 19 19 10 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322059_2 - 2.4e-27 94.7 222.6 2e-14 53.4 12.6 19.9 6 4 10 17 17 17 8 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322059_3 - 1.4e-49 166.0 242.0 2.5e-18 65.9 10.8 20.2 10 5 8 19 19 19 16 Domain of unknown function (DUF4705) Transposase_1 PF01359.16 T013927_1 - 2.5e-27 94.4 0.2 4.7e-27 93.5 0.2 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) DDE_1 PF03184.17 T013927_1 - 1.5e-06 27.8 0.2 2.3e-06 27.2 0.2 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 T013927_2 - 1e-06 28.6 0.1 2.3e-06 27.4 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.17 T013927_2 - 0.00063 19.2 0.1 0.0015 18.0 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease CCDC144C PF14915.4 T018812_2 - 6.9e-30 104.1 16.4 6.9e-30 104.1 16.4 2.4 3 0 0 3 3 3 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018812_2 - 1.7e-16 60.4 6.5 1.7e-16 60.4 6.5 3.5 3 1 0 3 3 3 1 Domain of unknown function (DUF3496) Phage_lysis PF03245.11 T018812_2 - 5.5 7.0 8.4 6.9 6.7 2.9 2.4 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein GIT_CC PF16559.3 T018812_2 - 7.5 6.6 9.0 32 4.5 1.2 3.2 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor CCDC144C PF14915.4 T018812_3 - 2.8e-30 105.4 13.6 2.8e-30 105.4 13.6 4.4 4 0 0 4 4 4 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018812_3 - 0.0029 17.5 1.1 0.0029 17.5 1.1 3.4 4 1 0 4 4 4 1 Laminin Domain II DUF1725 PF08333.9 T222937_1 - 9.1e-09 34.6 0.4 2e-08 33.5 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T222937_2 - 7.5e-32 110.5 0.6 1.2e-31 109.9 0.6 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phospho_p8 PF10195.7 T325318_1 - 0.046 14.1 0.0 0.078 13.3 0.0 1.3 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 rve PF00665.24 T342175_2 - 2.2e-09 37.4 0.0 4.6e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T342175_2 - 7.2e-07 29.3 0.5 1.7e-06 28.1 0.5 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RNase_H PF00075.22 T342175_3 - 3.4e-14 53.1 0.2 5.4e-14 52.5 0.2 1.3 1 0 0 1 1 1 1 RNase H Transposase_1 PF01359.16 T030529_1 - 2.8e-20 71.8 0.4 5.1e-20 71.0 0.4 1.3 1 0 0 1 1 1 1 Transposase (partial DDE domain) HTH_Tnp_IS630 PF01710.14 T030529_2 - 0.022 14.7 0.1 0.034 14.0 0.1 1.2 1 0 0 1 1 1 0 Transposase HTH_5 PF01022.18 T030529_2 - 0.056 13.2 0.0 0.096 12.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_24 PF13412.4 T030529_2 - 0.085 12.3 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding IF2_N PF04760.13 T030529_2 - 0.15 11.8 0.2 0.36 10.5 0.2 1.6 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region HTH_11 PF08279.10 T030529_2 - 0.18 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 HTH domain CTNNB1_binding PF08347.9 T190631_3 - 0.047 13.7 0.0 0.082 13.0 0.0 1.3 1 0 0 1 1 1 0 N-terminal CTNNB1 binding Peptidase_S49_N PF08496.8 T190631_3 - 0.37 10.8 4.7 0.57 10.1 4.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4798 PF16055.3 T190631_3 - 0.39 10.8 6.5 0.76 9.9 6.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4798) Mpp10 PF04006.10 T190631_3 - 4.4 5.5 12.2 5.7 5.1 12.2 1.0 1 0 0 1 1 1 0 Mpp10 protein Mit_proteolip PF08039.9 T001134_1 - 0.62 10.3 2.8 1.2 9.3 2.8 1.5 1 0 0 1 1 1 0 Mitochondrial proteolipid rve PF00665.24 T112509_2 - 2.1e-08 34.2 0.0 3.6e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain dUTPase PF00692.17 T112509_2 - 4.6e-08 32.7 0.0 8.1e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 dUTPase DUF1725 PF08333.9 T349020_2 - 1.7e-05 24.2 0.2 3.8e-05 23.1 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T349020_3 - 2.2e-33 115.5 1.7 1.1e-32 113.2 1.7 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T349020_3 - 0.036 13.6 1.9 0.09 12.3 1.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) GRIN_C PF15235.4 T349020_3 - 0.97 9.5 5.9 0.87 9.7 0.2 2.7 3 0 0 3 3 3 0 G protein-regulated inducer of neurite outgrowth C-terminus Trypan_PARP PF05887.9 T099746_3 - 2.4 8.1 139.7 1.9 8.4 15.8 6.1 1 1 4 5 5 5 0 Procyclic acidic repetitive protein (PARP) RVT_1 PF00078.25 T155321_3 - 7.8e-47 159.5 0.9 1.3e-46 158.8 0.9 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1777 PF08648.10 T316533_1 - 1.2e-05 25.5 13.6 2.1e-05 24.7 13.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) CDC45 PF02724.12 T316533_1 - 3.1 5.9 10.6 4.5 5.3 10.6 1.1 1 0 0 1 1 1 0 CDC45-like protein PRP38_assoc PF12871.5 T316533_1 - 4.1 7.9 42.0 8.6 6.9 42.0 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Trypan_PARP PF05887.9 T316533_1 - 10 6.0 10.7 20 5.1 10.7 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF1777 PF08648.10 T316533_2 - 5.3e-05 23.4 19.1 0.00016 21.9 19.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) IQ PF00612.25 T272769_3 - 0.0012 18.3 1.2 0.0052 16.3 0.1 2.5 2 0 0 2 2 2 1 IQ calmodulin-binding motif Transposase_22 PF02994.12 T351467_1 - 3.7e-151 503.0 20.2 4.9e-151 502.6 20.2 1.1 1 0 0 1 1 1 1 L1 transposable element KLRAQ PF10205.7 T351467_1 - 0.098 12.8 3.5 0.24 11.5 3.5 1.6 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Seryl_tRNA_N PF02403.20 T351467_1 - 0.19 11.9 5.7 0.32 11.1 5.7 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.12 T351467_1 - 4.4 6.9 8.5 11 5.6 8.5 1.6 1 0 0 1 1 1 0 IncA protein RVT_1 PF00078.25 T351467_3 - 1.4e-22 80.2 1.3 2.2e-22 79.5 1.3 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T351467_3 - 3.2e-10 40.1 0.0 5.4e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T351467_3 - 1.3e-07 31.3 1.1 2.9e-07 30.2 1.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-BED PF02892.13 T060450_2 - 0.0005 19.9 0.2 0.38 10.7 0.1 2.7 2 0 0 2 2 2 2 BED zinc finger Gag_p30 PF02093.14 T297833_3 - 0.00024 20.6 0.0 0.0004 19.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T297833_3 - 0.0071 15.8 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T353109_2 - 0.0076 15.7 0.3 0.015 14.8 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1028 PF06267.10 T258970_2 - 5.1 6.7 6.6 9.7 5.8 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) DUF1510 PF07423.9 T281044_1 - 0.21 10.9 26.2 0.34 10.2 26.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) MIP-T3 PF10243.7 T281044_2 - 0.064 11.8 39.0 0.092 11.3 39.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CDC45 PF02724.12 T281044_2 - 3.7 5.6 20.7 5.2 5.1 20.7 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.11 T281044_2 - 9.4 4.8 20.6 15 4.1 20.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MIP-T3 PF10243.7 T281044_3 - 0.47 9.0 37.5 0.66 8.5 37.5 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DDHD PF02862.15 T281044_3 - 3.3 7.7 5.6 4.9 7.1 5.6 1.1 1 0 0 1 1 1 0 DDHD domain AAA_11 PF13086.4 T281044_3 - 7.4 6.1 13.0 11 5.5 13.0 1.1 1 0 0 1 1 1 0 AAA domain CDC27 PF09507.8 T281044_3 - 9.2 5.4 30.2 13 4.9 30.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Transposase_1 PF01359.16 T287707_2 - 6.3e-08 32.2 0.0 1.4e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_22 PF02994.12 T214590_3 - 1.4e-86 290.5 25.3 2e-82 276.8 5.3 2.5 3 0 0 3 3 3 2 L1 transposable element Exo_endo_phos PF03372.21 T214590_3 - 6.1e-06 26.3 0.0 1.2e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family AMPKBI PF04739.13 T183085_3 - 0.016 15.4 2.2 26 5.0 0.0 3.5 3 0 0 3 3 3 0 5'-AMP-activated protein kinase beta subunit, interaction domain RNase_H PF00075.22 T274831_1 - 0.016 15.3 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 RNase H GP41 PF00517.15 T274831_2 - 1e-12 48.2 0.5 1.6e-12 47.5 0.5 1.2 1 0 0 1 1 1 1 Retroviral envelope protein RVT_1 PF00078.25 T274831_2 - 1.5e-09 37.6 0.0 2.2e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T004821_1 - 5.7e-19 68.6 0.0 1.1e-18 67.7 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T004821_1 - 9.2e-15 54.6 0.0 1.5e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T004821_1 - 9.6e-11 41.7 0.0 2e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T004821_1 - 1.9e-10 40.8 0.0 3.3e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T004821_2 - 3.7e-21 75.5 0.0 5.1e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T004821_3 - 1e-18 67.5 1.7 5.1e-16 58.7 0.8 2.2 2 0 0 2 2 2 2 Gag P30 core shell protein Gag_MA PF01140.17 T004821_3 - 8e-13 48.1 0.2 2e-12 46.8 0.0 1.7 2 0 0 2 2 2 1 Matrix protein (MA), p15 rve PF00665.24 T004821_3 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain FBPase PF00316.18 T361745_3 - 1e-10 41.3 0.0 1.7e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain CCDC144C PF14915.4 T018824_1 - 6.3e-29 100.9 16.4 6.3e-29 100.9 16.4 2.5 3 0 0 3 3 3 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018824_1 - 1.5e-15 57.4 6.5 1.5e-15 57.4 6.5 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3496) CCDC144C PF14915.4 T018824_2 - 2.7e-29 102.1 13.6 2.7e-29 102.1 13.6 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018824_2 - 3.1 7.7 19.2 0.025 14.5 1.1 2.5 2 0 0 2 2 2 0 Laminin Domain II BAR_3_WASP_bdg PF10456.7 T018824_3 - 1.3e-08 34.5 0.4 1.9e-08 34.0 0.4 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein CCDC144C PF14915.4 T018824_3 - 6.4e-07 28.7 3.0 8.7e-07 28.2 3.0 1.2 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region PT PF04886.10 T062527_1 - 7.2 6.1 16.9 0.6 9.6 0.0 4.7 4 0 0 4 4 4 0 PT repeat DUF4762 PF15959.3 T111993_1 - 0.8 9.6 4.6 3.3 7.7 4.6 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4762) GPHH PF16905.3 T111993_2 - 0.076 12.7 0.1 0.22 11.2 0.1 1.7 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated DUF4705 PF15788.3 T323207_1 - 5.1e-65 215.4 491.0 3.6e-08 33.4 4.4 46.2 27 8 13 40 40 40 32 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323207_2 - 3.9e-92 302.2 523.9 3.5e-17 62.2 8.0 46.2 27 13 14 41 41 41 28 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323207_3 - 7.7e-55 182.8 487.6 1.6e-08 34.4 7.0 44.5 24 15 18 42 42 42 26 Domain of unknown function (DUF4705) IQ PF00612.25 T272766_1 - 0.0014 18.1 1.2 0.0058 16.2 0.1 2.5 2 0 0 2 2 2 1 IQ calmodulin-binding motif TLV_coat PF00429.17 T091456_1 - 2.4e-39 135.3 3.4 4e-39 134.6 3.4 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) DUF1510 PF07423.9 T091456_1 - 2.6 7.3 14.7 4.4 6.5 14.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Gag_p30 PF02093.14 T091456_2 - 1.2e-14 54.3 0.0 1.8e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RNase_H PF00075.22 T091456_3 - 3.5e-12 46.6 0.0 5.9e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 RNase H RVP PF00077.18 T091456_3 - 2.9e-08 33.8 0.0 5.9e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Gag_p30 PF02093.14 T091456_3 - 0.2 11.0 0.6 0.33 10.3 0.0 1.6 2 0 0 2 2 2 0 Gag P30 core shell protein HERV-K_REC PF15695.3 T034735_3 - 2.2e-08 33.9 2.2 3.7e-08 33.2 2.2 1.3 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Transposase_22 PF02994.12 T281453_1 - 1.8e-53 181.6 0.3 2.7e-53 181.0 0.3 1.1 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T281453_2 - 1.1e-11 44.6 0.2 8.5e-11 41.7 0.2 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T281453_3 - 6.4e-52 176.5 11.8 2.1e-51 174.8 11.8 1.7 1 1 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T281453_3 - 1.3e-06 28.5 0.0 2.5e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T281453_3 - 0.018 14.8 0.0 0.046 13.5 0.0 1.7 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Seryl_tRNA_N PF02403.20 T281453_3 - 0.05 13.7 0.2 0.11 12.6 0.2 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.9 T281453_3 - 0.41 11.1 3.6 0.92 10.0 3.6 1.6 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Pentapeptide_4 PF13599.4 T358900_1 - 5.5e-12 45.5 5.4 1.5e-05 24.8 2.2 3.4 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) zf-CCHC PF00098.21 T012503_1 - 2.4e-05 24.1 2.6 2.4e-05 24.1 2.6 2.8 3 0 0 3 3 3 1 Zinc knuckle RVP PF00077.18 T012503_1 - 0.00072 19.7 0.0 0.002 18.2 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease Gag_p30 PF02093.14 T012503_2 - 0.0082 15.5 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein PRP9_N PF16958.3 T316686_1 - 3.5 7.5 6.4 5.5 6.9 6.4 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus VCX_VCY PF15231.4 T381755_1 - 8.9e-06 26.3 0.1 1.8e-05 25.3 0.1 1.4 1 0 0 1 1 1 1 Variable charge X/Y family RVT_1 PF00078.25 T288183_2 - 3.8e-40 137.6 1.0 5.7e-40 137.1 1.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T263456_1 - 7.7e-30 103.8 15.7 1.2e-29 103.2 15.7 1.2 1 0 0 1 1 1 1 L1 transposable element Seryl_tRNA_N PF02403.20 T263456_1 - 0.00062 19.8 4.6 0.0012 19.0 4.6 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.9 T263456_1 - 0.0032 17.9 4.9 0.0032 17.9 4.9 1.8 2 0 0 2 2 2 1 Syntaxin 6, N-terminal RVT_1 PF00078.25 T263456_2 - 9.3e-27 93.9 0.1 1.4e-26 93.3 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T263456_3 - 1.8e-103 346.1 7.5 3.8e-103 345.0 7.5 1.5 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T263456_3 - 1.1e-10 41.3 0.3 2.5e-10 40.1 0.3 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T263456_3 - 7e-10 39.0 0.0 1.4e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T263456_3 - 2.7e-08 33.5 0.4 8.4e-08 32.0 0.4 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF1725 PF08333.9 T263456_3 - 3e-08 33.0 0.7 8e-08 31.6 0.7 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Toxin_18 PF08087.9 T351117_2 - 2 8.4 6.1 4 7.4 0.6 2.6 2 0 0 2 2 2 0 Conotoxin O-superfamily RCDG1 PF15725.3 T351117_3 - 0.58 10.5 4.1 1.3 9.4 4.1 1.5 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein DMP1 PF07263.9 T229515_1 - 3 6.5 10.4 2.6 6.7 9.3 1.4 1 1 0 1 1 1 0 Dentin matrix protein 1 (DMP1) RVP PF00077.18 T229017_1 - 1e-25 89.8 0.1 1.9e-25 88.9 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease dUTPase PF00692.17 T229017_1 - 8e-16 57.8 0.0 1.3e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 dUTPase G-patch PF01585.21 T229017_1 - 1.1e-14 53.9 0.2 1.9e-14 53.2 0.2 1.4 1 0 0 1 1 1 1 G-patch domain HERV-K_env_2 PF13804.4 T229017_2 - 4.8e-119 394.0 2.7 9.5e-119 393.0 2.7 1.5 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Gag_p24 PF00607.18 T229017_2 - 1.1e-78 263.7 0.1 1.1e-78 263.7 0.1 2.0 3 0 0 3 3 3 1 gag gene protein p24 (core nucleocapsid protein) Gag_p10 PF02337.15 T229017_2 - 4.1e-30 103.3 0.5 1e-29 102.1 0.5 1.7 1 0 0 1 1 1 1 Retroviral GAG p10 protein RVT_thumb PF06817.12 T229017_2 - 1e-29 101.9 0.2 1e-29 101.9 0.2 2.8 3 0 0 3 3 3 1 Reverse transcriptase thumb domain rve PF00665.24 T229017_2 - 6.3e-29 100.5 0.0 1.5e-28 99.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain GP41 PF00517.15 T229017_2 - 2.7e-25 89.3 3.8 5e-25 88.4 3.8 1.4 1 0 0 1 1 1 1 Retroviral envelope protein RNase_H PF00075.22 T229017_2 - 1.1e-21 77.4 0.1 3.5e-21 75.8 0.0 2.0 2 0 0 2 2 1 1 RNase H zf-CCHC_5 PF14787.4 T229017_2 - 2.3e-21 75.1 6.4 2.3e-21 75.1 6.4 2.5 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger Integrase_Zn PF02022.17 T229017_2 - 5.7e-17 61.2 2.4 1.7e-16 59.7 2.4 1.9 1 0 0 1 1 1 1 Integrase Zinc binding domain IN_DBD_C PF00552.19 T229017_2 - 2.6e-06 26.5 1.5 6e-06 25.3 1.5 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain zf-CCHC PF00098.21 T229017_2 - 2.7e-06 27.1 2.5 2.7e-06 27.1 2.5 2.9 3 0 0 3 3 3 1 Zinc knuckle DDE_Tnp_IS240 PF13610.4 T229017_2 - 0.0046 17.0 0.0 0.0097 16.0 0.0 1.5 1 0 0 1 1 1 1 DDE domain zf-CCHC_6 PF15288.4 T229017_2 - 0.014 15.2 0.9 0.037 13.8 0.3 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.4 T229017_2 - 0.057 13.0 1.0 0.15 11.7 1.0 1.7 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.25 T229017_3 - 2.9e-34 118.4 0.0 5.5e-34 117.5 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T364417_3 - 0.005 16.3 0.6 0.015 14.8 0.6 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos_2 PF14529.4 T095950_1 - 4.3e-10 39.4 0.6 7.6e-10 38.6 0.6 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T095950_1 - 0.074 13.2 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Flg_hook PF02120.14 T095950_1 - 0.078 12.7 0.0 3.7 7.4 0.0 2.2 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK DUF1669 PF07894.10 T294481_2 - 1.7e-12 47.3 0.1 2.3e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) DUF1725 PF08333.9 T282001_2 - 0.00062 19.2 0.2 0.0013 18.2 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) HARP PF07443.11 T282001_2 - 0.023 14.2 1.8 0.028 13.9 0.1 2.1 2 0 0 2 2 2 0 HepA-related protein (HARP) RVT_1 PF00078.25 T282001_3 - 9.9e-25 87.2 0.1 1.6e-24 86.6 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_9 PF12781.5 T353749_3 - 1.9e-05 23.8 0.0 1.9e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 Ly49 PF08391.8 T353749_3 - 3.9 7.7 6.2 7.8 6.8 6.2 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF1725 PF08333.9 T184237_2 - 0.00021 20.7 0.9 0.0004 19.8 0.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) GP41 PF00517.15 T128225_2 - 2.8e-15 56.6 2.4 5.4e-15 55.6 2.4 1.4 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_REC PF15695.3 T128225_2 - 3.5e-07 30.1 2.8 7.5e-07 29.0 2.8 1.5 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Fusion_gly PF00523.16 T128225_2 - 0.16 10.1 2.4 0.13 10.4 0.2 1.7 2 0 0 2 2 2 0 Fusion glycoprotein F0 HERV-K_env_2 PF13804.4 T128225_3 - 3.4e-45 153.7 0.4 5.9e-45 152.9 0.4 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Cyt-b5 PF00173.26 T058840_2 - 8.3e-13 48.2 0.0 1.5e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Wbp11 PF09429.8 T094007_2 - 0.091 13.0 8.7 0.2 11.9 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 TGF_beta PF00019.18 T282642_3 - 3.9e-08 34.0 2.2 6.4e-08 33.3 2.2 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain DUF1725 PF08333.9 T282260_2 - 0.00016 21.1 0.2 0.00035 20.0 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_1 PF01359.16 T282260_3 - 1.1e-25 89.1 0.2 1.9e-25 88.4 0.2 1.4 1 0 0 1 1 1 1 Transposase (partial DDE domain) DUF1725 PF08333.9 T137529_1 - 1.9e-06 27.2 0.8 4.3e-06 26.1 0.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF3809 PF12723.5 T183026_3 - 0.08 13.1 0.1 4e+02 1.1 0.0 5.4 3 3 4 8 8 8 0 Protein of unknown function (DUF3809) DUF1028 PF06267.10 T258973_2 - 5.2 6.7 6.6 10 5.8 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) RNase_H PF00075.22 T263222_2 - 4.2e-17 62.5 0.0 8.7e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 RNase H rve PF00665.24 T263222_3 - 7.1e-18 64.8 0.0 1.6e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T263222_3 - 2.9e-08 33.7 0.7 8.2e-08 32.3 0.7 1.9 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.4 T263222_3 - 0.0016 18.0 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DUF1510 PF07423.9 T278187_2 - 0.77 9.0 28.1 1.2 8.3 28.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.12 T278187_2 - 2.1 6.4 33.3 2.9 5.9 33.3 1.1 1 0 0 1 1 1 0 CDC45-like protein PTPRCAP PF15713.3 T278187_2 - 6.6 6.9 16.5 15 5.7 16.5 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF262 PF03235.12 T278187_2 - 8.2 6.4 11.7 13 5.7 11.7 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 GAIN PF16489.3 T229052_2 - 1.7e-10 40.6 0.0 2.4e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.19 T229052_3 - 0.0029 18.1 0.1 0.0097 16.4 0.1 2.0 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif DUF3496 PF12001.6 T018764_1 - 2.2e-16 60.1 7.5 4.2e-16 59.2 7.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3496) BAR_3_WASP_bdg PF10456.7 T018764_2 - 9.9e-09 34.9 0.5 1.8e-08 34.0 0.5 1.3 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein DUF3496 PF12001.6 T018764_3 - 7.7e-09 35.8 0.0 1.3e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3496) DDHD PF02862.15 T161209_1 - 0.11 12.5 2.9 0.14 12.1 2.9 1.1 1 0 0 1 1 1 0 DDHD domain RNA_pol_Rpc4 PF05132.12 T161209_1 - 3 8.1 11.6 4.9 7.5 11.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 AAA_11 PF13086.4 T161209_1 - 4.2 6.9 14.9 5.7 6.5 14.9 1.1 1 0 0 1 1 1 0 AAA domain RR_TM4-6 PF06459.10 T161209_2 - 3.8 7.1 23.6 5 6.7 23.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.6 T161209_3 - 0.00071 18.3 9.0 0.00093 17.9 9.0 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.15 T161209_3 - 0.0074 14.9 12.1 0.0099 14.5 12.1 1.1 1 0 0 1 1 1 1 Presenilin DDHD PF02862.15 T161209_3 - 0.17 11.9 7.9 0.23 11.4 7.9 1.2 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.12 T161209_3 - 0.18 9.9 26.7 0.24 9.5 26.7 1.1 1 0 0 1 1 1 0 CDC45-like protein MIP-T3 PF10243.7 T161209_3 - 0.21 10.1 48.1 0.28 9.7 48.1 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF913 PF06025.10 T161209_3 - 4.3 6.1 7.6 5.9 5.6 7.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) AAA_21 PF13304.4 T161209_3 - 7.6 6.1 7.2 11 5.6 7.2 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system RNase_H PF00075.22 T172344_3 - 2e-05 24.7 0.0 4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 RNase H rve PF00665.24 T112514_3 - 1.6e-08 34.6 0.0 2.7e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain dUTPase PF00692.17 T112514_3 - 3.5e-08 33.1 0.0 6.2e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 dUTPase 7tm_4 PF13853.4 T112599_1 - 4.2e-17 62.6 7.5 9.1e-17 61.6 7.5 1.5 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 T112599_1 - 8.7e-09 34.9 1.5 2.2e-08 33.5 1.5 1.7 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ectatomin PF06457.9 T337202_1 - 0.19 11.5 25.8 60 3.5 0.0 10.1 13 0 0 13 13 13 0 Ectatomin Ectatomin PF06457.9 T337202_2 - 0.038 13.8 32.6 57 3.6 0.0 12.9 15 0 0 15 15 15 0 Ectatomin RVT_1 PF00078.25 T351462_2 - 1.4e-22 80.2 1.3 2.2e-22 79.5 1.3 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T351462_2 - 3.2e-10 40.1 0.0 5.3e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T351462_2 - 1.3e-07 31.3 1.1 2.9e-07 30.2 1.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Transposase_22 PF02994.12 T351462_3 - 3.6e-151 503.0 20.2 4.9e-151 502.6 20.2 1.1 1 0 0 1 1 1 1 L1 transposable element KLRAQ PF10205.7 T351462_3 - 0.096 12.8 3.5 0.23 11.6 3.5 1.6 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Seryl_tRNA_N PF02403.20 T351462_3 - 0.18 11.9 5.7 0.31 11.1 5.7 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.12 T351462_3 - 4.3 7.0 8.5 11 5.7 8.5 1.6 1 0 0 1 1 1 0 IncA protein Yae1_N PF09811.7 T229455_3 - 1.4 8.6 7.2 3 7.5 7.2 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Tektin PF03148.12 T383217_1 - 1.1e-36 126.3 2.3 2.4e-18 65.9 0.0 2.1 2 0 0 2 2 2 2 Tektin family Tektin PF03148.12 T383217_2 - 3.5e-12 45.6 0.6 4.4e-12 45.3 0.6 1.0 1 0 0 1 1 1 1 Tektin family CENP-B_N PF04218.11 T184891_1 - 5e-08 32.3 0.2 9.3e-08 31.5 0.2 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc5 PF03221.14 T184891_3 - 0.00013 21.8 0.1 0.00025 20.9 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.17 T184891_3 - 0.0075 15.7 0.1 0.016 14.7 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Toxin_13 PF07822.9 T229253_2 - 0.024 14.6 0.3 0.024 14.6 0.3 2.2 2 0 0 2 2 2 0 Neurotoxin B-IV-like protein MurB_C PF02873.14 T183004_3 - 0.16 12.0 0.1 13 5.9 0.0 3.2 1 1 1 2 2 2 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain RRM_1 PF00076.20 T209528_1 - 0.047 13.4 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 T209528_2 - 0.073 12.8 0.0 1.8 8.3 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4371 PF14291.4 T209528_3 - 0.00016 21.3 0.1 0.00027 20.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Baculo_11_kDa PF06143.9 T257780_3 - 1.4 8.4 4.7 3 7.4 4.7 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family Transposase_22 PF02994.12 T187866_1 - 6.8e-73 245.5 10.1 1.3e-46 159.0 0.2 3.4 3 0 0 3 3 3 3 L1 transposable element DUF1725 PF08333.9 T187866_1 - 1.1e-06 27.9 0.7 2.5e-06 26.8 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos PF03372.21 T187866_2 - 1.2e-09 38.3 0.0 2e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T187866_2 - 1.2e-07 31.5 1.6 2.3e-07 30.5 1.6 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.25 T187866_3 - 5.2e-48 163.3 1.0 7.9e-48 162.7 1.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T187866_3 - 3.9e-38 131.1 3.2 6.3e-38 130.4 3.2 1.3 1 0 0 1 1 1 1 L1 transposable element DUF1117 PF06547.10 T227239_3 - 0.0012 19.2 1.6 0.0023 18.3 1.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1117) LSPR PF06049.10 T352723_1 - 0.057 13.2 3.1 30 4.9 0.1 6.3 2 1 1 3 3 3 0 Coagulation Factor V LSPD Repeat Ephrin_rec_like PF07699.11 T352723_2 - 0.53 10.0 5.5 4.9 6.9 0.4 4.0 3 0 0 3 3 3 0 Putative ephrin-receptor like DUF4705 PF15788.3 T051862_1 - 1.1e-37 127.9 157.0 2.6e-14 53.0 8.5 15.9 8 4 6 15 15 15 10 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T051862_2 - 1.3e-07 31.6 18.4 0.00022 21.2 0.9 16.6 10 5 7 17 17 17 11 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T051862_3 - 1.4e-23 82.7 142.1 2e-09 37.4 6.3 14.7 10 3 3 13 13 13 8 Domain of unknown function (DUF4705) POM121 PF15229.4 T361768_1 - 1.4e-14 54.3 2.0 1.4e-14 54.3 2.0 1.7 2 0 0 2 2 2 1 POM121 family DUF1725 PF08333.9 T012475_1 - 7.9e-07 28.4 0.2 1.7e-06 27.4 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T012475_2 - 9.2e-07 28.5 3.0 2.2e-06 27.2 0.0 2.4 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T012475_3 - 4.1e-07 29.6 0.1 6.5e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T325348_1 - 1.2e-13 51.4 0.2 1.8e-13 50.8 0.2 1.2 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T325348_2 - 2.5e-19 69.5 0.8 5.8e-13 48.7 0.1 2.2 2 0 0 2 2 2 2 Gag P30 core shell protein RVT_1 PF00078.25 T325348_3 - 2.6e-15 56.4 0.1 8e-15 54.8 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T325348_3 - 6.3e-13 48.8 0.0 1.1e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Gag_p30 PF02093.14 T325348_3 - 0.006 16.0 0.2 0.01 15.3 0.2 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein DUF913 PF06025.10 T251536_1 - 6.7 5.4 8.1 13 4.5 8.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SDA1 PF05285.10 T251536_3 - 0.0018 17.7 56.1 0.0018 17.7 56.1 1.7 2 0 0 2 2 2 1 SDA1 Peptidase_S49_N PF08496.8 T188428_3 - 6 6.8 5.6 11 6.0 5.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF1028 PF06267.10 T259001_3 - 4.5 6.9 6.6 9.4 5.8 6.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF1028) DUF1725 PF08333.9 T184926_2 - 1.3e-06 27.8 0.3 2.7e-06 26.7 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) zf-RING_7 PF02591.13 T071095_1 - 0.09 12.9 14.5 18 5.5 0.3 7.1 10 0 0 10 10 10 0 C4-type zinc ribbon domain zf-RING_7 PF02591.13 T071095_2 - 0.01 15.9 19.0 33 4.6 0.1 8.7 10 0 0 10 10 10 0 C4-type zinc ribbon domain zf-RING_7 PF02591.13 T071095_3 - 1.2e-07 31.7 28.1 1.2 9.3 0.1 10.6 11 0 0 11 11 11 8 C4-type zinc ribbon domain HTH_Mga PF08280.9 T316853_2 - 7.7 6.5 8.4 21 5.1 0.1 3.6 4 0 0 4 4 4 0 M protein trans-acting positive regulator (MGA) HTH domain DUF1725 PF08333.9 T182466_3 - 0.049 13.2 0.5 0.09 12.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) FAM27 PF15832.3 T174277_1 - 2.3e-13 50.3 51.4 1.7e-07 31.6 14.7 5.0 6 0 0 6 6 6 3 FAM27 D and E protein family FAM27 PF15832.3 T174277_2 - 9.8e-11 41.9 36.3 3.8e-09 36.8 17.9 4.1 3 0 0 3 3 3 2 FAM27 D and E protein family zf-CCHC PF00098.21 T174277_2 - 0.023 14.6 6.6 0.0079 16.1 1.7 2.6 2 0 0 2 2 2 0 Zinc knuckle FAM27 PF15832.3 T174277_3 - 0.00027 21.3 11.1 0.00027 21.3 11.1 5.2 5 0 0 5 5 5 2 FAM27 D and E protein family AMPKBI PF04739.13 T183083_2 - 0.0014 18.7 2.0 11 6.2 0.0 3.4 3 0 0 3 3 3 3 5'-AMP-activated protein kinase beta subunit, interaction domain RVT_1 PF00078.25 T343479_1 - 0.012 15.0 0.1 0.018 14.4 0.1 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T343479_2 - 1.1e-35 123.0 0.6 1.8e-35 122.3 0.6 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T343479_2 - 7.8e-07 29.2 0.0 1.4e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T343479_3 - 8.4e-137 455.8 20.8 1.2e-136 455.3 20.8 1.2 1 0 0 1 1 1 1 L1 transposable element ATG16 PF08614.9 T343479_3 - 0.015 15.4 10.2 0.027 14.5 10.2 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) IncA PF04156.12 T343479_3 - 0.021 14.5 9.8 0.042 13.5 9.8 1.4 1 0 0 1 1 1 0 IncA protein Syntaxin-6_N PF09177.9 T343479_3 - 0.28 11.7 5.3 0.58 10.6 5.3 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Occludin_ELL PF07303.11 T343479_3 - 1 10.0 7.2 3.2 8.4 7.2 1.8 1 0 0 1 1 1 0 Occludin homology domain Spectrin PF00435.19 T343479_3 - 1.2 9.5 5.6 2.7 8.4 5.6 1.5 1 0 0 1 1 1 0 Spectrin repeat Seryl_tRNA_N PF02403.20 T343479_3 - 1.7 8.8 7.7 3.9 7.6 7.7 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MSG PF02349.13 T315666_2 - 0.1 12.7 6.0 23 5.1 0.2 3.4 1 1 3 4 4 4 0 Major surface glycoprotein Transposase_22 PF02994.12 T103482_2 - 1e-120 402.9 18.8 1.6e-120 402.2 18.8 1.3 1 0 0 1 1 1 1 L1 transposable element Seryl_tRNA_N PF02403.20 T103482_2 - 0.0024 18.0 5.8 0.0059 16.7 5.8 1.7 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain GAS PF13851.4 T103482_2 - 0.0072 15.6 7.6 0.016 14.4 7.6 1.6 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Prominin PF05478.9 T103482_2 - 0.016 13.1 4.1 0.022 12.6 4.1 1.1 1 0 0 1 1 1 0 Prominin KLRAQ PF10205.7 T103482_2 - 0.021 14.9 4.0 0.077 13.1 4.0 2.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Spectrin PF00435.19 T103482_2 - 0.022 15.1 3.9 0.12 12.7 3.5 2.0 1 1 0 1 1 1 0 Spectrin repeat Med2 PF11214.6 T103482_2 - 0.099 12.7 5.3 0.042 13.9 1.1 2.4 2 1 0 2 2 2 0 Mediator complex subunit 2 FAF PF11250.6 T103482_2 - 0.11 12.7 0.5 0.44 10.7 0.2 2.3 2 0 0 2 2 1 0 Fantastic Four meristem regulator DUF4613 PF15390.4 T103482_2 - 0.11 10.7 7.0 0.16 10.1 7.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF1664 PF07889.10 T103482_2 - 0.13 12.1 1.7 0.25 11.2 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) APG6 PF04111.10 T103482_2 - 0.13 11.5 8.8 0.19 10.9 8.8 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Troponin PF00992.18 T103482_2 - 0.15 12.2 10.9 0.057 13.6 7.0 2.2 1 1 1 2 2 2 0 Troponin Syntaxin-6_N PF09177.9 T103482_2 - 0.2 12.1 6.8 0.11 12.9 4.1 2.0 2 0 0 2 2 1 0 Syntaxin 6, N-terminal Sec8_exocyst PF04048.12 T103482_2 - 0.22 11.3 1.5 7.8 6.3 0.1 2.4 1 1 0 2 2 2 0 Sec8 exocyst complex component specific domain TBPIP PF07106.11 T103482_2 - 0.24 11.0 9.2 0.13 11.9 5.1 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF342 PF03961.11 T103482_2 - 0.36 9.3 10.0 0.14 10.6 7.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF342) XhlA PF10779.7 T103482_2 - 0.39 10.8 6.2 3.4 7.8 0.6 2.6 2 0 0 2 2 2 0 Haemolysin XhlA UCR_hinge PF02320.14 T103482_2 - 0.42 10.7 6.2 1.7 8.8 0.6 2.7 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein JIP_LZII PF16471.3 T103482_2 - 0.49 10.5 5.3 2.5 8.2 5.2 2.3 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II DUF972 PF06156.11 T103482_2 - 1.5 9.4 7.5 1.6 9.3 5.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Jnk-SapK_ap_N PF09744.7 T103482_2 - 1.7 8.7 11.1 3.9 7.5 11.1 1.6 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 IncA PF04156.12 T103482_2 - 2.4 7.8 12.4 0.17 11.6 7.2 1.7 2 0 0 2 2 2 0 IncA protein TPR_MLP1_2 PF07926.10 T103482_2 - 2.7 7.9 10.2 3.4 7.6 7.9 2.3 2 1 0 2 2 1 0 TPR/MLP1/MLP2-like protein ZapB PF06005.10 T103482_2 - 2.7 8.4 7.4 2.9 8.3 5.4 2.0 1 1 0 1 1 1 0 Cell division protein ZapB DUF2203 PF09969.7 T103482_2 - 3.5 8.2 6.6 1.3 9.6 1.5 2.6 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) Syntaxin_2 PF14523.4 T103482_2 - 3.8 7.8 8.4 5.9 7.2 0.3 3.0 1 1 2 3 3 3 0 Syntaxin-like protein DUF16 PF01519.14 T103482_2 - 5.7 7.4 7.3 1.6 9.1 3.1 2.3 2 1 0 2 2 1 0 Protein of unknown function DUF16 ATG16 PF08614.9 T103482_2 - 6.2 6.8 15.1 33 4.5 15.1 2.2 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) TMPIT PF07851.11 T103482_2 - 6.4 5.8 6.3 5.9 5.9 2.5 1.6 1 1 1 2 2 2 0 TMPIT-like protein DUF1725 PF08333.9 T183288_1 - 0.0066 15.9 0.8 0.016 14.7 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) GPS PF01825.19 T229030_2 - 0.00077 19.9 0.2 0.013 16.1 0.1 2.7 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif DUF1028 PF06267.10 T258974_1 - 4.5 6.9 6.6 9.7 5.8 6.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF1028) BAR_3_WASP_bdg PF10456.7 T018767_1 - 1.5e-08 34.3 0.5 2.5e-08 33.6 0.5 1.2 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein CCDC144C PF14915.4 T018767_2 - 2.2e-59 201.0 37.8 1.8e-35 122.4 14.1 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018767_2 - 2.2e-07 31.1 5.7 2.2e-07 31.1 5.7 3.9 3 1 1 4 4 4 1 Domain of unknown function (DUF3496) Laminin_II PF06009.10 T018767_2 - 1.9 8.4 13.2 0.029 14.2 1.1 2.5 2 0 0 2 2 2 0 Laminin Domain II CCDC144C PF14915.4 T018767_3 - 1.6e-16 60.2 9.6 2.8e-16 59.4 9.6 1.3 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region DUF1725 PF08333.9 T324950_1 - 0.1 12.1 0.3 0.22 11.1 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) zf-RVT PF13966.4 T336883_1 - 0.064 14.0 2.7 32 5.3 0.0 4.2 4 0 0 4 4 4 0 zinc-binding in reverse transcriptase Ank_3 PF13606.4 T336883_2 - 0.04 14.3 0.6 98 3.9 0.0 3.6 3 0 0 3 3 3 0 Ankyrin repeat DUF3678 PF12435.6 T179752_3 - 1.1 8.4 8.2 0.22 10.6 0.5 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) RVT_1 PF00078.25 T016082_1 - 8e-47 159.5 2.8 1.1e-46 159.0 2.8 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T016082_2 - 0.00021 20.7 0.1 0.00041 19.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Cut12 PF11500.6 T159176_1 - 1.8e-06 27.8 0.0 0.41 10.5 0.0 6.3 7 1 2 9 9 9 3 Spindle pole body formation-associated protein Lipocalin PF00061.21 T368849_2 - 0.013 15.6 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family RNase_H PF00075.22 T091453_1 - 3.6e-12 46.5 0.0 6.2e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 RNase H RVP PF00077.18 T091453_1 - 3.1e-08 33.7 0.0 6.1e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Gag_p30 PF02093.14 T091453_1 - 0.21 11.0 0.6 0.34 10.2 0.0 1.6 2 0 0 2 2 2 0 Gag P30 core shell protein TLV_coat PF00429.17 T091453_2 - 2.6e-39 135.3 3.4 4.1e-39 134.6 3.4 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) DUF1510 PF07423.9 T091453_2 - 2.7 7.2 14.7 4.6 6.5 14.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Gag_p30 PF02093.14 T091453_3 - 1.2e-14 54.2 0.0 1.8e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein GFO_IDH_MocA_C PF02894.15 T001693_3 - 0.096 12.6 0.0 0.28 11.1 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain DUF2484 PF10658.7 T183049_3 - 0.049 13.8 0.2 15 5.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2484) DUF4179 PF13786.4 T258483_1 - 0.16 12.3 6.3 3.8e+02 1.5 0.0 7.1 9 0 0 9 9 9 0 Domain of unknown function (DUF4179) DED PF01335.19 T258483_2 - 0.016 15.3 0.3 33 4.7 0.0 4.6 3 1 0 4 4 4 0 Death effector domain Transposase_22 PF02994.12 T012231_1 - 2e-26 92.6 6.6 5.7e-25 87.8 2.1 2.5 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T012231_1 - 0.02 14.4 0.3 0.044 13.3 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T012231_2 - 2.8e-38 131.5 1.9 2.4e-29 102.3 0.3 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T012231_3 - 3.5e-26 91.8 16.9 1.2e-19 70.3 0.0 3.7 4 0 0 4 4 4 3 L1 transposable element GPS2_interact PF15784.3 T215675_3 - 1.1e-19 70.8 0.2 1.5e-19 70.3 0.2 1.2 1 0 0 1 1 1 1 G-protein pathway suppressor 2-interacting domain RVT_1 PF00078.25 T041024_1 - 5.5e-06 25.9 0.0 9.2e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T239482_2 - 7.7e-52 175.9 1.8 7.7e-52 175.9 1.8 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.4 T239482_2 - 0.0022 17.5 0.3 0.0053 16.2 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4417) YlbE PF14003.4 T239482_2 - 0.094 13.0 8.4 0.33 11.3 0.0 3.4 3 0 0 3 3 3 0 YlbE-like protein Transposase_22 PF02994.12 T346739_2 - 5.2e-64 216.3 8.9 2e-57 194.6 5.4 2.2 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T346739_3 - 3.8e-35 121.3 1.9 6.6e-35 120.5 1.9 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T346739_3 - 5e-14 51.8 14.6 2.6e-07 29.7 2.9 2.2 2 0 0 2 2 2 2 L1 transposable element HSBP1 PF06825.10 T346739_3 - 0.026 14.3 0.1 0.059 13.2 0.1 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Ank PF00023.28 T040988_3 - 0.0046 17.2 0.0 0.015 15.6 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.5 T040988_3 - 0.0052 17.2 0.0 0.0094 16.4 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T040988_3 - 0.0077 16.5 0.0 0.019 15.3 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.4 T040988_3 - 0.087 13.1 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Transposase_1 PF01359.16 T351102_1 - 5.3e-21 74.1 7.5 1.5e-20 72.6 4.6 2.7 2 0 0 2 2 2 1 Transposase (partial DDE domain) DDE_3 PF13358.4 T351102_1 - 0.0028 17.3 0.4 0.0051 16.4 0.4 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BEN PF10523.7 T351102_1 - 0.053 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 BEN domain Transposase_1 PF01359.16 T351102_3 - 0.037 13.8 0.1 0.08 12.7 0.1 1.4 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_22 PF02994.12 T103711_1 - 2.8e-165 549.5 32.1 7.4e-142 472.4 20.5 2.2 2 0 0 2 2 2 2 L1 transposable element Exo_endo_phos PF03372.21 T103711_1 - 0.0052 16.9 0.0 0.13 12.4 0.0 2.3 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Spectrin PF00435.19 T103711_1 - 0.14 12.6 2.8 0.25 11.7 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat IncA PF04156.12 T103711_1 - 0.15 11.7 10.5 0.26 10.9 10.5 1.3 1 0 0 1 1 1 0 IncA protein Syntaxin-6_N PF09177.9 T103711_1 - 0.75 10.3 5.0 1.6 9.2 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103711_1 - 0.98 8.6 12.3 1.7 7.8 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103711_1 - 9.4 6.3 12.2 0.034 14.2 2.1 2.1 2 0 0 2 2 2 0 Mediator complex subunit 2 DUF1725 PF08333.9 T103711_2 - 0.00085 18.8 0.1 0.00085 18.8 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T103711_3 - 2.9e-63 213.8 26.2 3.3e-56 190.6 2.0 3.1 3 0 0 3 3 3 3 L1 transposable element RVT_1 PF00078.25 T103711_3 - 3.7e-12 46.1 0.0 6.3e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MIP-T3 PF10243.7 T035508_1 - 0.72 8.4 70.9 1.2 7.7 70.9 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Presenilin PF01080.15 T035508_3 - 5.1 5.6 27.5 7 5.2 27.5 1.1 1 0 0 1 1 1 0 Presenilin DUF3373 PF11853.6 T175810_2 - 0.13 10.9 0.3 0.19 10.3 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) PTPRCAP PF15713.3 T008081_2 - 0.39 10.9 34.7 0.58 10.3 34.7 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.12 T008081_2 - 0.85 7.7 24.7 1.1 7.3 24.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.10 T008081_2 - 3.4 6.9 35.3 4.9 6.4 35.3 1.1 1 0 0 1 1 1 0 SDA1 DDHD PF02862.15 T008081_3 - 0.0017 18.4 4.7 0.0024 17.9 4.7 1.1 1 0 0 1 1 1 1 DDHD domain RNA_pol_Rpc4 PF05132.12 T008081_3 - 0.037 14.3 14.9 0.058 13.7 14.9 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 RP-C_C PF11800.6 T008081_3 - 0.23 11.4 7.2 0.31 11.0 7.2 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region NPR3 PF03666.11 T008081_3 - 0.24 10.0 27.1 0.33 9.5 27.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Afi1 PF07792.10 T008081_3 - 0.33 11.3 8.7 0.66 10.3 8.7 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Phenol_monoox PF04663.10 T000050_2 - 2.7 8.1 10.6 35 4.6 0.1 5.1 6 0 0 6 6 6 0 Phenol hydroxylase conserved region RAMP4 PF06624.10 T000050_3 - 0.031 14.2 0.2 1.4e+02 2.5 0.0 4.9 5 1 1 6 6 6 0 Ribosome associated membrane protein RAMP4 GP41 PF00517.15 T064835_1 - 1.7e-13 50.8 5.2 2.9e-13 50.0 5.2 1.3 1 0 0 1 1 1 1 Retroviral envelope protein DUF3496 PF12001.6 T018730_1 - 1.1e-09 38.6 0.1 1.1e-09 38.6 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3496) DUF4795 PF16043.3 T018730_1 - 0.0025 17.3 4.5 0.0025 17.3 4.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4795) IncA PF04156.12 T018730_1 - 3.8 7.1 10.7 6.3 6.4 10.7 1.3 1 0 0 1 1 1 0 IncA protein V-set PF07686.15 T248998_2 - 5.2e-08 32.9 0.8 5.9e-07 29.5 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.14 T248998_2 - 0.001 19.0 0.1 0.045 13.7 0.0 2.9 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 T248998_2 - 0.0026 17.8 0.0 2.8 8.0 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 T248998_2 - 0.071 13.6 0.0 0.67 10.5 0.0 2.5 2 1 0 2 2 2 0 Immunoglobulin domain YesK PF14150.4 T248998_3 - 0.023 14.7 0.8 0.023 14.7 0.8 2.1 2 0 0 2 2 2 0 YesK-like protein GP41 PF00517.15 T128229_2 - 2.8e-15 56.6 2.4 5.3e-15 55.7 2.4 1.4 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_REC PF15695.3 T128229_2 - 3.7e-07 30.0 2.8 7.4e-07 29.0 2.8 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Fusion_gly PF00523.16 T128229_2 - 0.16 10.1 2.4 0.12 10.4 0.2 1.7 2 0 0 2 2 2 0 Fusion glycoprotein F0 HERV-K_env_2 PF13804.4 T128229_3 - 3.5e-45 153.7 0.4 5.7e-45 153.0 0.4 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein DUF1028 PF06267.10 T258988_2 - 5.6 6.6 6.6 11 5.7 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) Plasmodium_Vir PF05795.9 T305688_2 - 0.027 13.8 8.1 0.039 13.2 8.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RVT_1 PF00078.25 T266288_1 - 8.5e-20 71.1 0.2 1.4e-19 70.4 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T266288_3 - 7.2e-95 317.8 20.5 3.4e-92 309.0 10.8 2.2 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T266288_3 - 5e-06 25.9 2.1 1.2e-05 24.6 2.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) HSBP1 PF06825.10 T266288_3 - 0.43 10.4 1.9 0.85 9.5 0.3 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 RVT_1 PF00078.25 T016535_1 - 2.3e-05 23.9 0.1 2.3e-05 23.9 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) GTP-bdg_M PF16360.3 T016535_1 - 2.2 8.8 9.7 18 5.9 2.2 3.3 2 1 1 3 3 3 0 GTP-binding GTPase Middle Region Exo_endo_phos PF03372.21 T016535_2 - 1.9e-08 34.4 0.0 2.7e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T016535_2 - 5.1e-06 26.2 0.5 5.1e-06 26.2 0.5 1.7 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase RVT_1 PF00078.25 T016535_3 - 3.8e-13 49.3 0.0 5.6e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1564 PF07600.9 T111329_1 - 0.23 11.0 0.0 0.36 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1564) Transposase_22 PF02994.12 T046441_1 - 1.2e-67 228.3 15.0 6.4e-62 209.4 2.4 2.6 2 0 0 2 2 2 2 L1 transposable element Exo_endo_phos PF03372.21 T046441_1 - 0.0088 16.2 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.25 T046441_2 - 2.6e-21 76.0 0.0 4.3e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T046441_3 - 8.4e-77 258.4 25.4 2.9e-73 246.7 17.2 3.2 2 1 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T046441_3 - 8.2e-18 64.6 1.6 8.2e-18 64.6 1.6 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T046441_3 - 1.3e-13 50.0 1.5 1.2e-05 24.7 0.2 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF1725) Yae1_N PF09811.7 T229454_3 - 1.4 8.5 7.2 3 7.5 7.2 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal RVT_1 PF00078.25 T349586_1 - 2.9e-17 62.8 1.5 5e-17 62.0 1.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T349586_1 - 6.5e-08 31.9 0.6 1.3e-07 30.9 0.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T349586_3 - 4.7e-22 78.5 0.1 8.4e-22 77.6 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.4 T349586_3 - 7.1e-08 32.2 1.1 1.8e-07 30.9 1.1 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T349586_3 - 6.3e-06 26.3 0.0 1.4e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GAIN PF16489.3 T229053_2 - 6.1e-10 38.7 0.0 9.1e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain DUF1028 PF06267.10 T258963_1 - 5.2 6.7 6.6 9.9 5.8 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) UPAR_LY6 PF00021.19 T176629_1 - 2.6e-05 24.7 21.3 0.00079 20.0 5.5 3.6 3 0 0 3 3 3 2 u-PAR/Ly-6 domain Transposase_22 PF02994.12 T038091_2 - 1e-130 435.8 18.9 1e-130 435.8 18.9 1.8 2 0 0 2 2 2 1 L1 transposable element Exo_endo_phos PF03372.21 T038091_2 - 1.1e-07 32.0 0.0 2.3e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family KLRAQ PF10205.7 T038091_2 - 0.00047 20.2 3.3 0.0023 18.0 3.3 2.2 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein DUF1725 PF08333.9 T038091_2 - 0.14 11.7 0.3 0.38 10.3 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T038091_3 - 3.6e-44 150.8 3.4 5.4e-44 150.2 3.4 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lamprin PF06403.9 T260630_1 - 3.8 7.3 5.9 9 6.1 5.9 1.5 1 0 0 1 1 1 0 Lamprin Lamprin PF06403.9 T260630_3 - 0.87 9.4 7.1 2 8.2 7.1 1.5 1 0 0 1 1 1 0 Lamprin Gag_p30 PF02093.14 T297824_3 - 0.00042 19.8 0.0 0.00069 19.1 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T297824_3 - 0.011 15.1 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Colipase-like PF15083.4 T090329_3 - 5.1e-43 145.0 22.8 1.8e-31 108.0 11.6 2.6 2 0 0 2 2 2 2 Colipase-like DUF1510 PF07423.9 T338639_1 - 0.02 14.2 17.1 0.028 13.7 17.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) NPR3 PF03666.11 T338639_1 - 0.24 10.0 21.4 0.34 9.5 21.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1510 PF07423.9 T338639_2 - 0.028 13.7 17.7 0.042 13.2 17.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Presenilin PF01080.15 T338639_2 - 5.1 5.6 21.3 6.9 5.2 21.3 1.1 1 0 0 1 1 1 0 Presenilin DUF4705 PF15788.3 T324545_1 - 1.8e-34 117.5 484.8 1.3e-15 57.2 9.2 41.5 25 9 12 37 37 37 22 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324545_2 - 3e-11 43.2 61.4 5.3e-08 32.8 3.9 42.7 19 9 14 34 34 34 14 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324545_3 - 6.6e-80 263.0 436.0 1.2e-16 60.5 7.3 40.4 24 11 12 36 36 36 27 Domain of unknown function (DUF4705) RVT_1 PF00078.25 T287890_1 - 1.2e-16 60.8 1.9 2e-16 60.1 1.9 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T287890_1 - 1.5e-16 60.1 13.9 1.6e-08 33.7 11.9 2.9 2 1 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T287890_2 - 6.5e-16 58.4 0.1 1.1e-15 57.6 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T287890_3 - 2.9e-56 190.8 4.3 5.1e-56 190.0 4.3 1.2 1 0 0 1 1 1 1 L1 transposable element DUF1725 PF08333.9 T287890_3 - 2.3e-08 33.3 0.8 4.5e-08 32.4 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos PF03372.21 T287890_3 - 3.5e-08 33.5 0.0 5.9e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T287890_3 - 2.1e-06 27.5 0.8 4.1e-06 26.5 0.8 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF1725 PF08333.9 T265314_2 - 1.9e-08 33.6 0.8 3.5e-08 32.7 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T319431_3 - 1.4e-61 208.2 14.5 2e-61 207.8 14.5 1.2 1 0 0 1 1 1 1 L1 transposable element GAS PF13851.4 T319431_3 - 0.0023 17.2 9.3 0.0036 16.6 9.3 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Atg14 PF10186.7 T319431_3 - 0.0097 14.9 10.3 0.016 14.2 10.3 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spectrin PF00435.19 T319431_3 - 0.016 15.5 4.7 0.028 14.8 4.7 1.3 1 0 0 1 1 1 0 Spectrin repeat Seryl_tRNA_N PF02403.20 T319431_3 - 0.019 15.0 7.5 0.032 14.3 7.5 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.10 T319431_3 - 0.035 14.0 8.3 0.057 13.4 8.3 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF812 PF05667.9 T319431_3 - 0.044 12.6 13.1 0.065 12.0 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Sec34 PF04136.13 T319431_3 - 0.044 13.5 3.5 0.072 12.8 3.5 1.3 1 0 0 1 1 1 0 Sec34-like family Syntaxin-6_N PF09177.9 T319431_3 - 0.084 13.3 5.6 0.17 12.3 5.6 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Med2 PF11214.6 T319431_3 - 0.089 12.8 2.8 0.18 11.9 2.8 1.5 1 0 0 1 1 1 0 Mediator complex subunit 2 KLRAQ PF10205.7 T319431_3 - 0.1 12.7 6.9 0.093 12.9 5.2 1.7 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein APG6 PF04111.10 T319431_3 - 0.11 11.8 11.0 0.16 11.2 11.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4613 PF15390.4 T319431_3 - 0.19 9.9 5.3 0.28 9.4 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Mnd1 PF03962.13 T319431_3 - 0.21 11.3 8.5 0.34 10.6 8.5 1.2 1 0 0 1 1 1 0 Mnd1 family DUF1664 PF07889.10 T319431_3 - 0.21 11.5 2.4 0.35 10.7 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Spc7 PF08317.9 T319431_3 - 0.24 10.1 9.5 0.38 9.4 9.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein TBPIP PF07106.11 T319431_3 - 0.27 10.9 12.1 0.11 12.1 6.5 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) PspA_IM30 PF04012.10 T319431_3 - 0.5 9.8 4.8 0.83 9.1 4.8 1.2 1 0 0 1 1 1 0 PspA/IM30 family DUF16 PF01519.14 T319431_3 - 0.68 10.3 6.7 4.3 7.7 6.7 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF16 CENP-F_leu_zip PF10473.7 T319431_3 - 0.68 9.8 13.1 1.2 9.0 13.1 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Mod_r PF07200.11 T319431_3 - 0.71 9.8 8.1 1.2 9.1 8.1 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein ATG16 PF08614.9 T319431_3 - 0.85 9.6 14.1 2.3 8.2 14.0 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.7 T319431_3 - 1.4 9.0 14.1 2.1 8.5 14.1 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF724 PF05266.12 T319431_3 - 1.9 8.2 8.7 3.1 7.5 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Nup54 PF13874.4 T319431_3 - 2 8.4 6.4 2.9 7.8 6.4 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Occludin_ELL PF07303.11 T319431_3 - 2.1 9.0 4.6 4.4 7.9 4.6 1.5 1 0 0 1 1 1 0 Occludin homology domain DUF342 PF03961.11 T319431_3 - 2.4 6.5 7.6 3.4 6.0 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) UPF0449 PF15136.4 T319431_3 - 3.6 8.0 5.6 8.2 6.8 5.6 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 OmpH PF03938.12 T319431_3 - 4 7.3 7.5 1.2 9.0 3.9 1.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) RVT_1 PF00078.25 T291138_1 - 8e-46 156.2 2.5 1.3e-45 155.5 2.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSBP1 PF06825.10 T291138_1 - 0.0012 18.6 3.1 0.0017 18.1 1.0 2.2 2 0 0 2 2 2 1 Heat shock factor binding protein 1 Transposase_22 PF02994.12 T321830_2 - 4.9e-05 22.2 1.0 0.0003 19.6 1.0 1.9 1 1 0 1 1 1 1 L1 transposable element DUF1725 PF08333.9 T308773_3 - 7e-09 35.0 0.4 1.3e-08 34.1 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) hEGF PF12661.5 T219691_3 - 0.2 12.2 2.9 1 10.0 2.9 2.3 1 0 0 1 1 1 0 Human growth factor-like EGF LEA_5 PF00477.15 T051733_3 - 0.68 10.3 7.2 0.26 11.6 1.9 2.1 2 0 0 2 2 2 0 Small hydrophilic plant seed protein RVP PF00077.18 T228577_3 - 7e-13 48.6 0.0 1e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.4 T228577_3 - 0.024 15.2 0.0 0.043 14.4 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T228577_3 - 0.085 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Transposase_22 PF02994.12 T103719_2 - 2.1e-142 474.2 20.5 2.9e-142 473.8 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103719_2 - 0.03 14.5 0.0 0.056 13.6 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103719_2 - 0.059 13.0 10.5 0.11 12.2 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103719_2 - 0.06 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103719_2 - 0.34 11.4 5.0 0.69 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103719_2 - 0.42 9.8 12.3 0.74 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103719_2 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103719_2 - 3 8.0 7.5 5.3 7.2 6.7 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Tim54 PF11711.6 T051155_2 - 0.3 9.7 12.7 0.41 9.2 12.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDHD PF02862.15 T051155_2 - 3.5 7.6 7.6 5.6 6.9 7.6 1.2 1 0 0 1 1 1 0 DDHD domain Pentapeptide_4 PF13599.4 T360071_1 - 0.00018 21.4 0.0 3.3 7.8 0.0 3.0 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T360071_2 - 0.00015 21.7 0.1 1.2 9.2 0.0 3.0 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T360071_3 - 0.0012 18.7 0.0 10 6.2 0.0 3.0 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Mucin-like PF16058.3 T300745_2 - 0.0027 17.6 3.0 0.0064 16.4 3.0 1.6 1 0 0 1 1 1 1 Mucin-like Herpes_LMP1 PF05297.9 T300745_2 - 2.3 7.2 6.5 3.6 6.5 6.5 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Epiglycanin_C PF14654.4 T300745_3 - 3.4e-09 36.5 0.7 6.7e-09 35.6 0.7 1.5 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300745_3 - 2e-06 27.7 4.4 4.6e-06 26.5 4.4 1.6 1 0 0 1 1 1 1 Mucin-like zf-CCHC_5 PF14787.4 T167921_1 - 4e-16 58.3 1.3 1e-15 57.0 1.3 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger G-patch PF01585.21 T167921_1 - 4.3e-06 26.4 0.4 1.1e-05 25.2 0.4 1.6 1 0 0 1 1 1 1 G-patch domain Gag_p24 PF00607.18 T167921_1 - 0.00055 19.7 0.0 0.0009 19.0 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) HERV-K_REC PF15695.3 T167921_1 - 0.049 13.6 0.1 0.098 12.6 0.1 1.4 1 0 0 1 1 1 0 Rec (regulator of expression encoded by corf) of HERV-K-113 Gag_p24 PF00607.18 T167921_2 - 2.1e-28 99.4 0.0 9.1e-24 84.3 0.0 2.4 2 0 0 2 2 2 2 gag gene protein p24 (core nucleocapsid protein) rve PF00665.24 T167921_2 - 5.1e-22 78.2 0.0 1.7e-21 76.5 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Integrase_Zn PF02022.17 T167921_2 - 2e-13 49.9 0.7 6.1e-13 48.3 0.7 1.9 1 0 0 1 1 1 1 Integrase Zinc binding domain RVT_1 PF00078.25 T167921_2 - 5.2e-11 42.3 0.1 5e-10 39.1 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) IN_DBD_C PF00552.19 T167921_2 - 3.1e-07 29.5 0.8 9.4e-07 27.9 0.8 1.9 1 0 0 1 1 1 1 Integrase DNA binding domain Gag_p10 PF02337.15 T167921_2 - 9.7e-06 25.2 0.1 2e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 Retroviral GAG p10 protein DDE_Tnp_IS240 PF13610.4 T167921_2 - 0.011 15.8 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 DDE domain RNase_H PF00075.22 T167921_2 - 0.13 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 RNase H RVT_thumb PF06817.12 T167921_3 - 7.2e-17 60.7 0.0 1.4e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVP PF00077.18 T167921_3 - 3.1e-15 56.1 0.1 6.3e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease dUTPase PF00692.17 T167921_3 - 3.9e-14 52.3 0.0 7.2e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 dUTPase RNase_H PF00075.22 T167921_3 - 6.1e-07 29.6 0.0 9.6e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 RNase H IN_DBD_C PF00552.19 T167921_3 - 6.7e-05 22.0 0.2 0.00014 20.9 0.2 1.5 1 0 0 1 1 1 1 Integrase DNA binding domain Gag_p10 PF02337.15 T167921_3 - 0.00013 21.6 0.3 0.00031 20.4 0.0 1.7 2 0 0 2 2 2 1 Retroviral GAG p10 protein Filament PF00038.19 T167921_3 - 0.26 10.7 0.1 0.39 10.1 0.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein DUF1028 PF06267.10 T258989_3 - 5.3 6.6 6.6 10 5.7 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) Gag_p30 PF02093.14 T383932_1 - 2e-05 24.1 0.0 3.2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein HERV-K_REC PF15695.3 T383932_2 - 7.5e-08 32.2 3.4 1.9e-07 30.9 3.4 1.6 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 RVP PF00077.18 T383932_2 - 4.1e-05 23.7 0.0 9.6e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.21 T383932_2 - 0.0066 16.4 2.6 0.016 15.1 2.6 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-C2H2_10 PF16588.3 T383932_2 - 0.041 13.5 1.0 0.11 12.1 1.0 1.7 1 0 0 1 1 1 0 C2H2 zinc-finger gag-asp_proteas PF13975.4 T383932_2 - 0.18 12.3 0.0 0.31 11.5 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease HERV-K_env_2 PF13804.4 T383932_3 - 2e-37 128.4 0.3 4.2e-37 127.4 0.3 1.4 1 1 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Connexin PF00029.17 T040788_1 - 0.05 13.2 1.3 0.083 12.5 1.3 1.3 1 0 0 1 1 1 0 Connexin Eapp_C PF10238.7 T040788_1 - 0.91 9.5 5.3 2 8.4 5.3 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein RR_TM4-6 PF06459.10 T040788_1 - 2.7 7.6 7.5 3.6 7.2 7.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TT_ORF1 PF02956.12 T040788_2 - 0.76 8.2 33.0 1.2 7.6 33.0 1.2 1 0 0 1 1 1 0 TT viral orf 1 CDC45 PF02724.12 T040788_2 - 1.7 6.8 38.2 2.2 6.4 38.2 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.8 T040788_3 - 0.79 10.0 9.9 1.4 9.2 9.9 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain rve PF00665.24 T230578_1 - 1.1e-24 86.8 0.0 2.3e-24 85.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_5 PF14787.4 T230578_1 - 3.6e-19 68.0 7.6 8.7e-19 66.8 7.6 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Integrase_Zn PF02022.17 T230578_1 - 8.7e-15 54.3 2.7 2.4e-14 52.8 2.7 1.9 1 0 0 1 1 1 1 Integrase Zinc binding domain RNase_H PF00075.22 T230578_1 - 3.7e-08 33.6 0.0 6.7e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 RNase H GP41 PF00517.15 T230578_1 - 1.6e-05 24.7 0.1 3e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Retroviral envelope protein DDE_Tnp_IS240 PF13610.4 T230578_1 - 0.036 14.1 0.0 0.057 13.5 0.0 1.2 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.25 T230578_1 - 0.037 13.4 0.1 0.069 12.5 0.1 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.12 T230578_2 - 1e-07 31.4 0.4 1.9e-07 30.6 0.4 1.4 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVT_1 PF00078.25 T230578_2 - 2.2e-05 23.9 0.0 3.4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Borrelia_orfX PF04160.10 T230578_2 - 0.018 14.9 0.4 0.031 14.2 0.4 1.3 1 0 0 1 1 1 0 Orf-X protein RVP PF00077.18 T230578_2 - 0.16 12.1 0.1 1.1 9.5 0.1 2.1 1 1 0 1 1 1 0 Retroviral aspartyl protease Gag_p24 PF00607.18 T230578_3 - 1.1e-69 234.3 1.3 1.8e-69 233.6 0.3 1.8 2 0 0 2 2 2 1 gag gene protein p24 (core nucleocapsid protein) HERV-K_env_2 PF13804.4 T230578_3 - 7.1e-65 217.7 2.8 1.4e-64 216.8 2.8 1.4 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_REC PF15695.3 T230578_3 - 1.7e-28 98.4 5.6 4.3e-28 97.1 5.6 1.7 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Gag_p10 PF02337.15 T230578_3 - 2.2e-27 94.6 0.2 5.1e-27 93.4 0.2 1.6 1 0 0 1 1 1 1 Retroviral GAG p10 protein RVT_thumb PF06817.12 T230578_3 - 8.3e-16 57.3 0.0 2.4e-15 55.8 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase thumb domain dUTPase PF00692.17 T230578_3 - 4.7e-10 39.1 0.0 9.1e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 dUTPase IN_DBD_C PF00552.19 T230578_3 - 2e-06 26.8 1.2 4.5e-06 25.7 1.2 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain GP41 PF00517.15 T230578_3 - 8.6e-06 25.6 2.1 0.006 16.3 0.0 2.3 2 0 0 2 2 2 2 Retroviral envelope protein zf-CCHC PF00098.21 T230578_3 - 1e-05 25.2 2.5 1e-05 25.2 2.5 2.2 2 0 0 2 2 2 1 Zinc knuckle RVT_1 PF00078.25 T230578_3 - 0.0014 18.0 0.1 0.0025 17.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_6 PF15288.4 T230578_3 - 0.45 10.3 4.9 0.098 12.4 0.4 2.2 2 0 0 2 2 2 0 Zinc knuckle BAR_3_WASP_bdg PF10456.7 T223035_1 - 2.9e-08 33.3 0.2 4.3e-08 32.8 0.2 1.2 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein DDE_1 PF03184.17 T223035_3 - 2.1e-11 43.6 0.4 2.3e-06 27.2 0.0 2.2 2 0 0 2 2 2 2 DDE superfamily endonuclease Gag_p24 PF00607.18 T097014_1 - 8.6e-05 22.4 0.0 0.00013 21.7 0.0 1.1 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) HERV-K_env_2 PF13804.4 T097014_2 - 7.9e-51 172.0 0.2 1.2e-50 171.4 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_REC PF15695.3 T097014_2 - 0.00066 19.5 0.7 0.0013 18.7 0.7 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 GP41 PF00517.15 T097014_3 - 1.7e-14 54.0 5.8 3.3e-14 53.1 5.8 1.4 1 0 0 1 1 1 1 Retroviral envelope protein Fusion_gly PF00523.16 T097014_3 - 0.049 11.7 0.1 0.07 11.2 0.1 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 GAIN PF16489.3 T229054_1 - 5.6e-10 38.9 0.0 7.9e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.19 T229054_2 - 0.003 18.1 0.1 0.01 16.4 0.1 2.0 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif DUF4705 PF15788.3 T324666_1 - 2.3e-15 56.4 165.3 0.0042 17.1 16.1 14.8 11 3 1 12 12 12 9 Domain of unknown function (DUF4705) Ribosomal_S3_C PF00189.18 T324666_1 - 0.075 13.4 0.3 16 6.0 0.1 2.7 2 0 0 2 2 2 0 Ribosomal protein S3, C-terminal domain DUF4705 PF15788.3 T324666_2 - 0.0012 18.8 10.2 0.0012 18.8 10.2 15.7 10 4 4 14 14 14 8 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324666_3 - 3.1e-31 107.2 181.6 5.2e-05 23.2 9.3 15.8 11 4 4 15 15 15 10 Domain of unknown function (DUF4705) PTP_N PF12453.6 T324666_3 - 3.1 7.4 6.2 2.1e+02 1.6 0.1 4.2 4 0 0 4 4 4 0 Protein tyrosine phosphatase N terminal DUF4455 PF14643.4 T131478_3 - 3.8e-08 32.4 0.4 4.8e-08 32.1 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4455) IQ PF00612.25 T272751_2 - 0.0048 16.4 0.1 0.0048 16.4 0.1 3.0 3 0 0 3 3 3 1 IQ calmodulin-binding motif TMEM191C PF15194.4 T230005_1 - 2e-47 160.1 5.5 2e-47 160.1 5.5 1.6 2 0 0 2 2 2 1 TMEM191C family ATG16 PF08614.9 T230005_3 - 1.6 8.7 15.3 4 7.4 1.7 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF1725 PF08333.9 T184430_3 - 0.54 9.9 2.5 0.96 9.1 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) Filament PF00038.19 T078928_1 - 1.6e-40 139.5 14.0 2e-40 139.2 14.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein BRE1 PF08647.9 T078928_1 - 0.46 10.4 10.1 0.72 9.8 2.9 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase CALCOCO1 PF07888.9 T078928_1 - 0.52 8.7 11.7 0.7 8.3 11.7 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like MscS_porin PF12795.5 T078928_1 - 0.62 9.4 10.2 0.88 8.9 10.2 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Spc7 PF08317.9 T078928_1 - 1.3 7.7 11.4 2.4 6.8 11.2 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.5 T078928_1 - 3.8 7.5 12.9 5.8 6.9 12.9 1.1 1 0 0 1 1 1 0 Tropomyosin like Muted PF14942.4 T078928_1 - 6.1 7.0 10.5 9.1 6.4 10.5 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Plant_tran PF04827.12 T138464_2 - 0.15 11.5 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Plant transposon protein Gag_p24 PF00607.18 T274840_1 - 1e-26 94.0 0.0 1.5e-26 93.4 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) dUTPase PF00692.17 T274840_1 - 2.4e-18 65.9 0.0 3.8e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 dUTPase Transposase_22 PF02994.12 T274840_1 - 3e-06 26.2 3.8 4.3e-06 25.7 3.8 1.1 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T274840_1 - 8.8e-05 22.0 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T274840_1 - 0.048 13.7 0.0 0.076 13.1 0.0 1.2 1 0 0 1 1 1 0 RNase H GP41 PF00517.15 T274840_2 - 3e-12 46.7 0.5 5.3e-12 45.9 0.5 1.3 1 0 0 1 1 1 1 Retroviral envelope protein RVT_1 PF00078.25 T274840_2 - 4.8e-09 35.9 0.0 6.9e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_5 PF14787.4 T274840_2 - 2.3e-06 27.1 19.1 5.2e-06 25.9 8.7 3.1 2 1 0 2 2 2 2 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.21 T274840_2 - 0.00086 19.1 6.2 0.0046 16.9 6.2 2.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.4 T274840_2 - 0.099 12.2 2.5 0.22 11.1 2.5 1.6 1 0 0 1 1 1 0 Zinc knuckle RVT_thumb PF06817.12 T274840_3 - 1.7e-24 85.1 0.6 4.2e-24 83.9 0.6 1.7 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVP PF00077.18 T274840_3 - 2e-20 72.8 0.0 4.6e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.24 T274840_3 - 2.2e-18 66.5 0.0 4.2e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Gag_p10 PF02337.15 T274840_3 - 5e-14 51.8 0.2 1.1e-13 50.6 0.2 1.6 1 0 0 1 1 1 1 Retroviral GAG p10 protein RVT_1 PF00078.25 T274840_3 - 2e-13 50.2 0.1 3.5e-13 49.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p24 PF00607.18 T274840_3 - 2.7e-12 46.9 0.2 4.9e-12 46.0 0.2 1.3 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) RNase_H PF00075.22 T274840_3 - 5.2e-11 42.8 0.1 8.6e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 RNase H G-patch PF01585.21 T274840_3 - 1.2e-08 34.6 2.2 2.2e-08 33.8 2.2 1.4 1 0 0 1 1 1 1 G-patch domain Integrase_Zn PF02022.17 T274840_3 - 0.00072 19.3 1.5 0.0029 17.4 1.5 2.1 1 0 0 1 1 1 1 Integrase Zinc binding domain IN_DBD_C PF00552.19 T274840_3 - 0.00086 18.4 5.6 0.0063 15.7 3.1 2.4 2 0 0 2 2 2 1 Integrase DNA binding domain Transposase_1 PF01359.16 T361166_3 - 7.6e-27 92.9 0.2 1.7e-26 91.7 0.2 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) HTH_32 PF13565.4 T361166_3 - 0.00045 20.6 0.0 0.00084 19.8 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.16 T361166_3 - 0.0035 17.4 0.0 0.0058 16.7 0.0 1.3 1 0 0 1 1 1 1 Transposase HTH_24 PF13412.4 T361166_3 - 0.0062 15.9 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_23 PF13384.4 T361166_3 - 0.0087 15.7 0.1 0.42 10.4 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_11 PF08279.10 T361166_3 - 0.019 14.7 0.1 0.043 13.6 0.1 1.5 1 0 0 1 1 1 0 HTH domain HTH_28 PF13518.4 T361166_3 - 0.021 14.8 0.0 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain MarR_2 PF12802.5 T361166_3 - 0.026 14.3 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 MarR family DDE_3 PF13358.4 T361166_3 - 0.032 13.8 0.1 0.064 12.9 0.1 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_17 PF12728.5 T361166_3 - 0.09 12.8 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Pentapeptide_2 PF01469.16 T051565_1 - 0.0075 16.0 6.1 0.17 11.7 3.5 2.4 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) AT_hook PF02178.17 T228595_1 - 0.095 12.5 5.9 0.34 10.8 5.9 2.0 1 0 0 1 1 1 0 AT hook motif DUF3060 PF11259.6 T051120_2 - 1.1e-05 24.8 0.0 5 6.8 0.0 4.2 2 1 1 4 4 4 4 Protein of unknown function (DUF3060) DUF296 PF03479.13 T051120_2 - 0.19 12.2 6.6 8.6e+02 0.4 6.6 4.0 1 1 0 1 1 1 0 Domain of unknown function (DUF296) RNase_H PF00075.22 T172331_3 - 2.6e-05 24.3 0.0 4.2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 RNase H Eapp_C PF10238.7 T068774_1 - 0.054 13.5 3.7 0.12 12.3 3.7 1.6 1 0 0 1 1 1 0 E2F-associated phosphoprotein Coilin_N PF15862.3 T068774_1 - 0.067 12.8 15.5 0.11 12.2 15.5 1.3 1 0 0 1 1 1 0 Coilin N-terminus RR_TM4-6 PF06459.10 T068774_1 - 0.2 11.3 15.3 0.31 10.7 15.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.15 T068774_1 - 0.28 11.1 2.0 0.45 10.5 2.0 1.2 1 0 0 1 1 1 0 DDHD domain NARP1 PF12569.6 T068774_1 - 0.71 8.5 20.0 0.98 8.1 20.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Rrn6 PF10214.7 T068774_1 - 1.7 6.8 9.8 2.6 6.2 9.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1510 PF07423.9 T068774_1 - 2.7 7.3 16.5 4.4 6.6 16.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CCDC71L PF15374.4 T068774_1 - 3 6.9 12.6 4.6 6.3 12.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L SpoIIP PF07454.9 T068774_1 - 5.1 6.3 8.8 8.4 5.6 8.8 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FLO_LFY PF01698.14 T068774_1 - 5.2 6.0 10.0 7.7 5.5 10.0 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Tim54 PF11711.6 T068774_1 - 5.2 5.6 14.1 7.5 5.1 14.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AAA_11 PF13086.4 T068774_1 - 5.2 6.6 10.7 7.9 6.0 10.7 1.1 1 0 0 1 1 1 0 AAA domain Sec62 PF03839.14 T068774_1 - 6.4 6.1 17.8 11 5.3 17.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4672 PF15716.3 T196650_1 - 0.035 13.6 1.1 0.069 12.6 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) Transposase_1 PF01359.16 T122300_1 - 5.2e-22 77.4 0.2 9.9e-22 76.5 0.2 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) HERV-K_REC PF15695.3 T128223_3 - 1.6e-07 31.2 1.6 3.7e-07 30.0 1.6 1.6 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 zf-H2C2 PF09337.8 T339231_1 - 0.055 13.6 0.1 0.13 12.4 0.1 1.7 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger NADHdh_A3 PF14987.4 T210985_1 - 7.4 6.9 12.2 17 5.7 0.3 5.0 1 1 3 5 5 5 0 NADH dehydrogenase 1 alpha subcomplex subunit 3 HERV-K_REC PF15695.3 T383934_2 - 1.8e-06 27.7 3.0 3.7e-06 26.8 3.0 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 LisH PF08513.9 T318094_1 - 0.11 12.4 0.5 74 3.4 0.2 4.0 4 0 0 4 4 4 0 LisH Toxin_18 PF08087.9 T318094_2 - 0.092 12.6 12.9 0.73 9.7 1.3 3.1 2 0 0 2 2 2 0 Conotoxin O-superfamily DUF4705 PF15788.3 T322057_1 - 8.6e-29 99.4 249.5 2.2e-14 53.2 12.6 21.8 8 5 10 19 19 19 9 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322057_2 - 1.1e-46 156.6 271.9 2.8e-18 65.7 10.8 22.6 11 6 9 21 21 21 17 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T322057_3 - 5.2e-20 71.3 240.3 1.5e-06 28.1 6.1 21.0 15 4 3 18 18 18 13 Domain of unknown function (DUF4705) RNA_pol_Rpc4 PF05132.12 T336370_1 - 9.9 6.5 11.3 19 5.5 11.3 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 AAA_11 PF13086.4 T336370_2 - 1.8 8.1 14.5 2.8 7.5 14.5 1.2 1 0 0 1 1 1 0 AAA domain Hydrolase_3 PF08282.10 T336370_2 - 6.3 6.3 6.2 9.1 5.8 6.2 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase RNA_pol_Rpc4 PF05132.12 T336370_2 - 8.5 6.7 10.2 22 5.4 10.2 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 Eapp_C PF10238.7 T336370_3 - 0.0039 17.2 0.8 0.0064 16.5 0.8 1.4 1 0 0 1 1 1 1 E2F-associated phosphoprotein AAA_11 PF13086.4 T336370_3 - 0.094 12.3 5.1 0.13 11.8 5.1 1.1 1 0 0 1 1 1 0 AAA domain Connexin PF00029.17 T336370_3 - 1.3 8.6 7.4 2.3 7.8 7.4 1.3 1 0 0 1 1 1 0 Connexin zf-C2H2_10 PF16588.3 T222944_1 - 9 6.0 10.3 16 5.2 1.9 2.7 2 0 0 2 2 2 0 C2H2 zinc-finger PELOTA_1 PF15608.4 T165129_2 - 1 9.1 8.8 10 5.9 0.2 3.4 1 1 4 5 5 5 0 PELOTA RNA binding domain RVT_1 PF00078.25 T267165_3 - 1.1e-27 96.9 2.0 1.5e-27 96.4 2.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T267165_3 - 4.3e-07 29.3 0.1 8.7e-07 28.3 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) PHO4 PF01384.18 T138166_3 - 0.0011 18.0 0.0 0.0011 18.0 0.0 1.1 1 0 0 1 1 1 1 Phosphate transporter family Gag_p30 PF02093.14 T274108_1 - 0.0073 15.7 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Transposase_22 PF02994.12 T274108_3 - 6.3e-83 278.5 5.0 6.3e-83 278.5 5.0 1.6 2 0 0 2 2 2 1 L1 transposable element RVT_1 PF00078.25 T274108_3 - 5.7e-48 163.2 5.3 4.3e-47 160.3 2.5 2.6 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T274108_3 - 1.1e-07 31.1 0.7 2.4e-07 30.1 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) zf-CCHC PF00098.21 T274108_3 - 0.002 18.0 2.0 0.002 18.0 2.0 2.2 2 0 0 2 2 2 1 Zinc knuckle RVP PF00077.18 T274108_3 - 0.0093 16.1 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Pentapeptide_4 PF13599.4 T193719_1 - 2.6e-06 27.3 0.0 1.9 8.5 0.0 3.8 3 1 1 4 4 4 3 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.4 T193719_3 - 0.0003 20.7 0.0 6.9 6.7 0.0 3.6 3 1 1 4 4 4 3 Pentapeptide repeats (9 copies) RVT_1 PF00078.25 T346314_1 - 2.7e-15 56.3 0.4 2.7e-15 56.3 0.4 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T346314_3 - 5e-100 334.8 17.6 1e-98 330.4 10.6 2.3 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T346314_3 - 3.2e-21 75.7 0.8 1.2e-20 73.9 0.1 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T346314_3 - 3.3e-05 23.3 0.0 8.8e-05 21.9 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos PF03372.21 T346314_3 - 0.04 14.0 0.0 0.093 12.9 0.0 1.6 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family PRP9_N PF16958.3 T316678_1 - 2.4 8.0 8.2 3.8 7.4 8.2 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus Colipase-like PF15083.4 T090325_3 - 9.1e-45 150.6 26.6 8.8e-38 128.2 13.6 2.7 1 1 1 2 2 2 2 Colipase-like MIP-T3 PF10243.7 T090325_3 - 2.9 6.4 62.6 5.3 5.5 62.6 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 TMEM191C PF15194.4 T229526_1 - 8.3e-28 96.8 7.7 3.9e-27 94.6 8.1 1.9 2 0 0 2 2 2 1 TMEM191C family DUF883 PF05957.11 T229526_1 - 0.0093 16.4 7.2 0.019 15.4 7.2 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF883) Exonuc_VII_L PF02601.13 T229526_1 - 0.16 11.4 1.8 0.21 11.0 1.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit IncA PF04156.12 T229526_1 - 0.42 10.3 11.4 0.7 9.5 11.4 1.2 1 0 0 1 1 1 0 IncA protein ADIP PF11559.6 T229526_1 - 0.67 9.9 11.2 1.1 9.2 11.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding OmpH PF03938.12 T229526_1 - 0.83 9.5 10.6 1.1 9.1 10.6 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Jnk-SapK_ap_N PF09744.7 T229526_1 - 2.7 8.1 15.0 4.3 7.4 15.0 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 FUSC PF04632.10 T229526_1 - 3.4 6.0 10.1 5.4 5.3 10.1 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Syntaxin-6_N PF09177.9 T229526_1 - 4.1 7.9 6.8 11 6.6 6.0 1.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal TerB_C PF15615.4 T229526_1 - 5 7.3 7.2 7.9 6.6 7.2 1.2 1 0 0 1 1 1 0 TerB-C domain APG6 PF04111.10 T229526_1 - 7.1 5.8 9.6 10 5.3 9.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 TMEM191C PF15194.4 T229526_3 - 3.2e-09 36.8 0.1 8.5e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 TMEM191C family ExsD PF16806.3 T229526_3 - 4.7 6.9 7.6 6.6 6.4 7.6 1.1 1 0 0 1 1 1 0 Antiactivator protein ExsD RVT_1 PF00078.25 T012477_1 - 4.4e-07 29.5 0.1 7e-07 28.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T012477_2 - 8.2e-07 28.4 0.2 1.8e-06 27.3 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T012477_3 - 1.1e-06 28.2 3.0 2.4e-06 27.1 0.0 2.4 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) AT_hook PF02178.17 T228573_3 - 0.35 10.7 5.9 2.9 8.0 5.9 2.6 1 0 0 1 1 1 0 AT hook motif DUF1669 PF07894.10 T293917_1 - 3.9e-15 56.0 0.3 5.6e-15 55.5 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) Hexapep PF00132.22 T293917_1 - 6.8e-10 38.2 4.3 1.2 8.9 0.2 7.8 8 0 0 8 8 8 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.4 T293917_1 - 6.8 6.4 8.0 1.2e+02 2.4 0.1 5.7 6 0 0 6 6 6 0 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.22 T293917_3 - 0.00037 20.0 0.6 0.037 13.6 0.0 4.4 5 0 0 5 5 5 1 Bacterial transferase hexapeptide (six repeats) DUF1725 PF08333.9 T356804_2 - 7.7e-06 25.3 0.7 1.5e-05 24.3 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) EloA-BP1 PF15870.3 T356804_3 - 5.7e-10 39.6 0.1 8.9e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 ElonginA binding-protein 1 RVT_1 PF00078.25 T344415_1 - 7.2e-32 110.6 0.3 1.2e-31 109.8 0.3 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T344415_2 - 2.6e-34 118.6 13.4 2.3e-33 115.5 4.7 2.4 2 0 0 2 2 2 2 L1 transposable element Transposase_22 PF02994.12 T344415_3 - 7.1e-33 113.8 0.3 1.3e-32 113.0 0.3 1.4 1 0 0 1 1 1 1 L1 transposable element DUF1028 PF06267.10 T258971_2 - 5.7 6.6 6.6 11 5.7 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) CCDC144C PF14915.4 T018818_1 - 1.1e-29 103.5 16.4 1.1e-29 103.5 16.4 3.0 3 0 0 3 3 3 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018818_1 - 2.6e-16 59.8 6.5 2.6e-16 59.8 6.5 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3496) CCDC144C PF14915.4 T018818_2 - 4.5e-30 104.7 13.6 4.5e-30 104.7 13.6 3.3 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018818_2 - 0.0044 16.9 1.1 0.0044 16.9 1.1 2.8 3 0 0 3 3 3 1 Laminin Domain II Peptidase_S49_N PF08496.8 T188439_2 - 2.8 7.9 4.6 5.1 7.0 4.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Gag_p30 PF02093.14 T325355_2 - 2.3e-19 69.6 0.8 5.7e-13 48.7 0.1 2.3 2 0 0 2 2 2 2 Gag P30 core shell protein RVT_1 PF00078.25 T325355_3 - 2.6e-15 56.4 0.1 7.9e-15 54.8 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T325355_3 - 0.006 16.0 0.2 0.0099 15.3 0.2 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein GP41 PF00517.15 T202687_1 - 4.9e-10 39.5 0.3 8.2e-10 38.7 0.3 1.3 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_env_2 PF13804.4 T202687_2 - 4.6e-37 127.2 0.2 7.2e-37 126.6 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein IQ PF00612.25 T272762_2 - 0.001 18.6 1.2 0.0049 16.4 0.1 2.5 2 0 0 2 2 2 1 IQ calmodulin-binding motif DUF1725 PF08333.9 T182467_3 - 0.048 13.2 0.5 0.093 12.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) DUF4705 PF15788.3 T323230_1 - 0.0072 16.4 38.0 0.0096 16.0 15.3 5.6 4 1 1 5 5 5 2 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323230_3 - 4.3e-06 26.7 22.5 0.00016 21.7 6.4 7.4 7 2 2 9 9 9 2 Domain of unknown function (DUF4705) Transposase_22 PF02994.12 T082056_1 - 7e-26 90.8 0.8 1e-25 90.2 0.8 1.2 1 0 0 1 1 1 1 L1 transposable element DUF1725 PF08333.9 T082056_1 - 9.7e-05 21.8 0.4 0.00021 20.7 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF1725 PF08333.9 T082056_3 - 0.0003 20.2 1.0 0.0007 19.1 1.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T014635_2 - 4.6e-06 26.2 0.0 7.3e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3915 PF13054.4 T062743_2 - 1.1 9.1 2.4 2 8.3 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 T062743_3 - 0.042 13.7 2.1 0.07 13.0 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Hexapep PF00132.22 T293914_1 - 0.00052 19.5 0.2 0.043 13.4 0.0 4.2 4 0 0 4 4 4 1 Bacterial transferase hexapeptide (six repeats) DUF1669 PF07894.10 T293914_2 - 4.5e-15 55.8 0.3 6.5e-15 55.3 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) Hexapep PF00132.22 T293914_2 - 1.7e-09 36.9 4.0 1.4 8.7 0.2 7.6 8 0 0 8 8 8 4 Bacterial transferase hexapeptide (six repeats) EPF PF17181.2 T317092_1 - 0.016 15.0 6.4 0.084 12.7 6.4 2.3 1 0 0 1 1 1 0 Epidermal patterning factor proteins Arylesterase PF01731.18 T381515_3 - 0.053 13.6 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Arylesterase Transposase_1 PF01359.16 T069601_3 - 5.3e-18 64.5 0.2 5.3e-18 64.5 0.2 2.3 2 0 0 2 2 2 1 Transposase (partial DDE domain) MRP-L28 PF09812.7 T369084_2 - 1.9 8.5 5.5 3.8 7.5 5.5 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 Transposase_22 PF02994.12 T076755_3 - 8.7e-14 51.0 7.3 1.2e-13 50.5 7.3 1.1 1 0 0 1 1 1 1 L1 transposable element Toxin_16 PF07945.9 T353280_3 - 0.00029 20.5 256.8 1.5 8.6 1.4 38.1 4 2 35 39 39 39 36 Janus-atracotoxin SAPS PF04499.13 T081036_2 - 0.83 8.2 13.2 1.1 7.8 13.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.15 T081036_2 - 9 4.8 27.4 14 4.2 27.4 1.1 1 0 0 1 1 1 0 Presenilin Integrase_Zn PF02022.17 T338691_1 - 1.7e-11 43.7 1.7 1.7e-11 43.7 1.7 3.4 3 1 0 3 3 3 1 Integrase Zinc binding domain RVT_1 PF00078.25 T338691_1 - 2e-05 24.1 0.0 3.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T338691_1 - 0.015 15.2 3.8 0.044 13.7 3.8 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.4 T338691_1 - 0.035 13.7 5.7 0.098 12.2 5.7 1.8 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger rve PF00665.24 T338691_2 - 6.7e-23 81.0 0.0 1.2e-22 80.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T338691_2 - 3.6e-09 36.8 0.0 6.3e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 RNase H DDE_Tnp_IS240 PF13610.4 T338691_2 - 0.012 15.7 0.0 0.018 15.1 0.0 1.2 1 0 0 1 1 1 0 DDE domain IN_DBD_C PF00552.19 T338691_3 - 5.7e-07 28.6 0.4 5.7e-07 28.6 0.4 1.7 2 0 0 2 2 2 1 Integrase DNA binding domain RVP PF00077.18 T338691_3 - 2.8e-05 24.2 0.0 5.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease GP41 PF00517.15 T338691_3 - 0.00039 20.2 0.2 0.00039 20.2 0.2 2.3 3 0 0 3 3 3 1 Retroviral envelope protein rve PF00665.24 T338691_3 - 0.00065 19.8 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Borrelia_orfX PF04160.10 T338691_3 - 0.012 15.6 0.6 0.03 14.2 0.6 1.6 1 0 0 1 1 1 0 Orf-X protein DUF1028 PF06267.10 T258966_3 - 5.1 6.7 6.6 9.6 5.8 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) Ank PF00023.28 T040987_2 - 0.013 15.8 0.0 0.03 14.6 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeat Ank_2 PF12796.5 T040987_2 - 0.014 15.8 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_3 PF13606.4 T040987_2 - 0.023 15.1 0.0 0.063 13.7 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeat Ank_5 PF13857.4 T040987_2 - 0.14 12.4 0.1 0.28 11.5 0.1 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) RVT_1 PF00078.25 T201492_2 - 6.6e-36 123.8 1.0 1e-35 123.1 1.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T201492_3 - 8.9e-09 34.6 0.9 2.9e-08 33.0 0.9 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos PF03372.21 T201492_3 - 0.0046 17.1 0.1 0.019 15.1 0.1 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.25 T074879_3 - 0.00032 20.2 0.0 0.00051 19.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4641 PF15483.4 T376187_1 - 6.8e-165 549.4 20.6 6.8e-165 549.4 20.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4641) DUF3616 PF12275.6 T169753_3 - 0.2 10.9 0.2 3.4 6.9 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3616) SSP160 PF06933.9 T111411_1 - 1 7.4 22.9 1.5 6.8 22.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF1725 PF08333.9 T293625_1 - 0.00045 19.7 2.1 0.0011 18.4 2.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T293625_1 - 0.00059 19.3 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mit_proteolip PF08039.9 T293625_1 - 0.47 10.7 5.3 0.98 9.6 5.3 1.4 1 0 0 1 1 1 0 Mitochondrial proteolipid Transposase_22 PF02994.12 T293625_2 - 8.5e-27 93.8 5.0 2.1e-24 85.9 1.8 2.3 2 0 0 2 2 2 2 L1 transposable element Mit_proteolip PF08039.9 T293625_2 - 1.9 8.7 7.9 1 9.6 5.0 1.9 2 0 0 2 2 2 0 Mitochondrial proteolipid RVT_1 PF00078.25 T293625_3 - 1.5e-22 80.1 3.0 2.9e-22 79.1 3.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mit_proteolip PF08039.9 T293625_3 - 0.65 10.2 5.0 1.7 8.9 5.0 1.6 1 0 0 1 1 1 0 Mitochondrial proteolipid Glyco_hydro_2_C PF02836.15 T286604_3 - 2.1e-17 63.0 0.1 2.7e-17 62.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Lamprin PF06403.9 T211120_2 - 0.0016 18.3 12.7 0.52 10.1 0.3 3.5 2 1 1 3 3 3 3 Lamprin Ubiquitin_3 PF14836.4 T138229_1 - 0.31 10.8 1.2 14 5.5 1.2 3.0 1 1 0 1 1 1 0 Ubiquitin-like domain WAP PF00095.19 T073910_3 - 0.00016 21.8 11.6 0.0017 18.6 11.6 2.3 1 1 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' IQ PF00612.25 T272756_3 - 0.00095 18.6 1.2 0.0048 16.4 0.1 2.6 2 0 0 2 2 2 1 IQ calmodulin-binding motif Reoviridae_Vp9 PF08978.8 T350671_1 - 0.25 10.4 0.7 0.39 9.7 0.7 1.1 1 0 0 1 1 1 0 Reoviridae VP9 DUF1943 PF09172.9 T325744_3 - 0.093 11.9 7.9 0.55 9.3 1.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1943) DUF1997 PF09366.8 T325744_3 - 7.9 6.5 8.3 13 5.8 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1997) GABP-alpha PF11620.6 T255912_3 - 0.0097 16.0 4.3 12 6.1 0.0 7.1 6 2 2 8 8 8 1 GA-binding protein alpha chain RVT_1 PF00078.25 T337379_1 - 1.4e-09 37.7 0.0 2.1e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T337379_2 - 2.4e-37 128.5 0.8 3.8e-37 127.8 0.8 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T337379_3 - 0.00012 21.5 0.0 0.00026 20.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF4551 PF15087.4 T021194_1 - 9.9 4.7 5.9 13 4.3 5.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) V1R PF03402.12 T034769_1 - 3.8e-06 26.6 0.4 5.9e-06 26.0 0.4 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R V1R PF03402.12 T034769_2 - 1.4e-08 34.5 1.0 2.4e-08 33.8 1.0 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R IN_DBD_C PF00552.19 T126062_1 - 2.2e-07 29.9 0.6 4.6e-07 28.9 0.6 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain HERV-K_REC PF15695.3 T126062_2 - 1.6e-06 28.0 1.5 2.6e-06 27.3 1.5 1.3 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 HERV-K_env_2 PF13804.4 T126062_2 - 0.00016 21.3 0.0 0.00029 20.5 0.0 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein RVT_1 PF00078.25 T261075_3 - 1e-28 100.3 0.3 3.2e-28 98.6 0.2 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T239484_1 - 6e-52 176.2 1.8 1.2e-51 175.2 1.8 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.4 T239484_1 - 0.0032 17.0 0.3 0.0071 15.8 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4417) YlbE PF14003.4 T239484_1 - 0.24 11.7 8.8 0.43 10.9 0.0 3.3 3 0 0 3 3 3 0 YlbE-like protein DUF1725 PF08333.9 T215541_1 - 6.9e-07 28.6 0.9 1.6e-06 27.5 0.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) IncA PF04156.12 T215541_2 - 2.9 7.5 8.7 6.2 6.4 8.7 1.5 1 0 0 1 1 1 0 IncA protein Transposase_22 PF02994.12 T215541_3 - 2.7e-117 391.6 11.5 5e-117 390.7 11.5 1.4 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T215541_3 - 3.8e-42 144.2 1.2 6.6e-42 143.4 1.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T215541_3 - 0.00044 20.3 0.1 0.002 18.3 0.0 1.9 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T095115_1 - 4.3e-27 94.8 2.2 7.8e-27 94.0 2.2 1.4 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T095115_3 - 3.8e-31 108.2 0.8 6.5e-31 107.4 0.2 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T095115_3 - 8.9e-17 60.8 0.0 1.6e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 L1 transposable element DUF1725 PF08333.9 T095115_3 - 0.057 13.0 0.1 0.18 11.4 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) DUF3709 PF12493.6 T095115_3 - 0.7 9.9 3.1 1.9 8.4 3.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3709) Transposase_22 PF02994.12 T163127_3 - 2.4e-99 332.5 11.3 2.4e-99 332.5 11.3 1.7 2 0 0 2 2 2 1 L1 transposable element CENP-B_dimeris PF09026.8 T040786_1 - 0.39 11.0 9.7 0.69 10.2 9.7 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF262 PF03235.12 T040786_1 - 1.5 8.8 12.9 2.1 8.4 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 Nop25 PF09805.7 T040786_1 - 4.2 7.7 55.0 5.8 7.3 55.0 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) AAA_15 PF13175.4 T040786_1 - 5.6 6.3 30.2 7.3 6.0 30.2 1.0 1 0 0 1 1 1 0 AAA ATPase domain Connexin PF00029.17 T040786_2 - 0.026 14.2 1.3 0.044 13.4 1.3 1.3 1 0 0 1 1 1 0 Connexin RR_TM4-6 PF06459.10 T040786_2 - 1.5 8.5 7.5 1.9 8.1 7.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1510 PF07423.9 T040786_3 - 0.002 17.5 17.6 0.0029 16.9 17.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) SpoIIIAH PF12685.5 T040786_3 - 0.0063 16.2 2.6 0.0086 15.8 2.6 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein CDC45 PF02724.12 T040786_3 - 0.0071 14.6 33.7 0.0095 14.2 33.7 1.0 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.10 T040786_3 - 0.29 9.2 30.2 0.38 8.8 30.2 1.0 1 0 0 1 1 1 0 Nop14-like family TT_ORF1 PF02956.12 T040786_3 - 0.56 8.7 33.1 0.71 8.4 33.1 1.1 1 0 0 1 1 1 0 TT viral orf 1 MIP-T3 PF10243.7 T040786_3 - 0.77 8.3 35.5 1 7.9 35.5 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 BUD22 PF09073.8 T040786_3 - 2.9 7.0 28.0 4.9 6.2 28.0 1.3 1 0 0 1 1 1 0 BUD22 Apt1 PF10351.7 T040786_3 - 5.5 5.6 9.3 7.3 5.2 9.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain SDA1 PF05285.10 T040786_3 - 5.6 6.2 33.6 8 5.7 33.6 1.1 1 0 0 1 1 1 0 SDA1 HTH_Mga PF08280.9 T316862_3 - 8.7 6.3 14.5 37 4.3 0.4 5.0 5 0 0 5 5 5 0 M protein trans-acting positive regulator (MGA) HTH domain CTD PF12815.5 T259445_1 - 1.3e-16 60.8 88.2 1.4e-06 28.6 17.5 8.0 6 3 2 8 8 8 4 Spt5 C-terminal nonapeptide repeat binding Spt4 Mucin-like PF16058.3 T259445_2 - 4.4e-07 29.8 35.7 1.4e-05 25.0 10.4 10.4 4 2 5 10 10 10 4 Mucin-like CTD PF12815.5 T259445_3 - 2.3e-15 56.8 118.7 9.2e-07 29.2 16.0 7.1 5 1 4 9 9 9 6 Spt5 C-terminal nonapeptide repeat binding Spt4 Mucin-like PF16058.3 T259445_3 - 7.5e-05 22.6 41.5 0.00018 21.4 15.5 10.7 4 1 9 13 13 13 5 Mucin-like Caskin1-CID PF16600.3 T259445_3 - 0.015 15.8 0.9 1.3e+02 3.2 0.0 5.2 5 0 0 5 5 5 0 Caskin1 CASK-interaction domain GFO_IDH_MocA_C PF02894.15 T001704_3 - 0.13 12.2 0.0 0.34 10.8 0.0 1.6 2 0 0 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain POM121 PF15229.4 T361757_2 - 1.9e-23 83.3 5.8 1.9e-23 83.3 5.8 2.3 2 0 0 2 2 2 1 POM121 family zf-BED PF02892.13 T060455_1 - 6.7e-08 32.3 0.4 0.42 10.6 0.1 4.5 4 0 0 4 4 4 3 BED zinc finger DUF3505 PF12013.6 T060455_1 - 0.045 14.1 0.2 60 4.0 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3505) DUF678 PF05077.10 T060455_1 - 0.13 12.2 1.9 38 4.4 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF678) Transposase_1 PF01359.16 T013930_2 - 2.4e-27 94.5 0.2 4.6e-27 93.6 0.2 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) DDE_1 PF03184.17 T013930_2 - 1.4e-06 27.8 0.2 2.2e-06 27.2 0.2 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 T013930_3 - 9.8e-07 28.6 0.1 2.2e-06 27.5 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.17 T013930_3 - 0.00061 19.3 0.1 0.0015 18.0 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease rve PF00665.24 T215475_1 - 4.9e-18 65.3 0.0 6.8e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T215475_3 - 2.8e-10 40.2 0.5 5.6e-10 39.2 0.5 1.5 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Transposase_1 PF01359.16 T330239_1 - 0.0015 18.2 1.9 0.0033 17.1 1.9 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T330239_3 - 1.6e-18 66.2 0.0 3.5e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) Pentapeptide_2 PF01469.16 T051530_3 - 0.0053 16.5 6.3 0.52 10.1 1.1 2.4 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) TMEM191C PF15194.4 T230006_3 - 4.9e-48 162.1 4.8 1.1e-47 161.0 4.8 1.5 1 0 0 1 1 1 1 TMEM191C family ADIP PF11559.6 T230006_3 - 4.2 7.3 13.3 3 7.8 1.4 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Syntaxin-6_N PF09177.9 T230006_3 - 8.5 6.9 8.7 6.2 7.3 2.1 2.2 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF1725 PF08333.9 T224642_3 - 3.5e-08 32.7 0.9 5.7e-08 32.1 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Wbp11 PF09429.8 T093971_2 - 0.087 13.1 8.7 0.2 12.0 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 Transposase_22 PF02994.12 T016496_1 - 1.2e-30 106.5 1.6 1.7e-30 106.0 1.6 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T016496_1 - 2e-07 31.2 0.0 3.3e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T016496_2 - 4.1e-40 137.6 16.9 6.3e-40 137.0 16.9 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T016496_2 - 4.1e-05 23.7 0.0 7.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GCN5L1 PF06320.11 T016496_2 - 0.016 15.2 1.9 0.03 14.3 1.9 1.4 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) Syntaxin-6_N PF09177.9 T016496_2 - 0.16 12.4 7.0 0.32 11.4 7.0 1.4 1 0 0 1 1 1 0 Syntaxin 6, N-terminal IncA PF04156.12 T016496_2 - 1.7 8.2 7.8 3.5 7.2 7.8 1.4 1 0 0 1 1 1 0 IncA protein Transposase_22 PF02994.12 T016496_3 - 1e-79 268.0 3.9 9.2e-47 159.5 0.4 2.3 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T016496_3 - 1.1e-41 142.7 0.8 1.5e-41 142.2 0.8 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T016496_3 - 3.5e-06 26.4 0.3 1e-05 24.9 0.3 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Ig_3 PF13927.4 T069794_3 - 3.4e-34 117.2 0.7 3.7e-09 36.9 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 T069794_3 - 8.5e-27 93.2 0.0 7.5e-08 32.5 0.1 5.4 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 T069794_3 - 5.8e-16 58.3 0.1 0.00058 19.9 0.0 5.7 5 2 0 5 5 5 3 Immunoglobulin domain I-set PF07679.14 T069794_3 - 1.1e-12 47.7 0.0 3.5e-06 26.9 0.0 4.6 4 1 0 4 4 4 3 Immunoglobulin I-set domain C2-set_2 PF08205.10 T069794_3 - 1.9e-06 27.7 13.6 0.066 13.2 0.0 6.1 5 2 0 5 5 5 2 CD80-like C2-set immunoglobulin domain fn3 PF00041.19 T069794_3 - 2.8e-06 27.4 0.0 1e-05 25.7 0.0 2.0 2 0 0 2 2 2 1 Fibronectin type III domain V-set PF07686.15 T069794_3 - 0.016 15.2 3.5 12 6.0 0.7 4.5 3 2 1 4 4 4 0 Immunoglobulin V-set domain Utp12 PF04003.10 T124924_1 - 0.54 10.4 2.3 60 3.9 0.0 3.9 2 1 1 3 3 3 0 Dip2/Utp12 Family Utp12 PF04003.10 T124924_3 - 0.028 14.6 8.4 9.5 6.4 0.1 4.9 5 0 0 5 5 5 0 Dip2/Utp12 Family DUF331 PF03889.11 T291614_2 - 0.32 10.4 2.7 0.29 10.5 1.2 1.7 2 0 0 2 2 2 0 Domain of unknown function Ig_3 PF13927.4 T291614_3 - 0.0051 17.3 0.0 0.074 13.5 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 T291614_3 - 0.042 13.8 0.0 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin I-set domain DUF4705 PF15788.3 T324659_1 - 2.5e-13 49.8 142.9 3.4e-05 23.8 0.2 17.2 11 6 1 12 12 12 7 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T324659_3 - 8.2e-24 83.4 43.8 3.6e-18 65.4 10.4 17.0 12 7 5 17 17 17 8 Domain of unknown function (DUF4705) SPX PF03105.17 T071522_1 - 5.9 6.6 12.6 9.2 6.0 12.6 1.2 1 0 0 1 1 1 0 SPX domain HMG_box PF00505.17 T260447_2 - 7.2e-10 39.0 0.0 1.4e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T260447_2 - 0.0036 17.7 0.0 0.0071 16.8 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain RVT_1 PF00078.25 T307661_1 - 5e-51 173.2 2.0 7.5e-51 172.6 2.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T307661_1 - 1.9e-05 24.8 0.0 3.5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T307661_1 - 0.00013 21.7 0.1 0.00032 20.4 0.1 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Transposase_22 PF02994.12 T307661_2 - 5.9e-26 91.1 20.9 1.9e-24 86.1 20.9 2.2 1 1 0 1 1 1 1 L1 transposable element Med2 PF11214.6 T307661_2 - 0.011 15.7 0.4 0.024 14.6 0.4 1.5 1 0 0 1 1 1 0 Mediator complex subunit 2 Transposase_22 PF02994.12 T307661_3 - 2.3e-42 145.0 2.0 1.3e-39 136.0 0.5 3.0 2 1 1 3 3 3 2 L1 transposable element CitMHS PF03600.14 T049498_2 - 0.031 13.4 7.2 0.056 12.5 7.2 1.3 1 0 0 1 1 1 0 Citrate transporter UPF0061 PF02696.12 T038702_1 - 4.9e-11 41.9 0.0 6e-11 41.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family PRAP PF15314.4 T041916_3 - 0.3 11.4 7.4 25 5.3 0.2 3.9 4 0 0 4 4 4 0 Proline-rich acidic protein 1, pregnancy-specific uterine DUF1028 PF06267.10 T259011_3 - 5.9 6.5 6.6 11 5.6 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) RST PF12174.6 T352789_1 - 1.6 8.6 24.0 56 3.7 0.0 12.4 15 3 2 17 17 17 0 RCD1-SRO-TAF4 (RST) plant domain RST PF12174.6 T352789_2 - 1.4 8.8 29.1 26 4.7 0.0 13.3 16 3 1 19 19 19 0 RCD1-SRO-TAF4 (RST) plant domain RST PF12174.6 T352789_3 - 0.02 14.8 22.1 26 4.7 0.0 12.1 13 1 0 14 14 14 0 RCD1-SRO-TAF4 (RST) plant domain Transposase_22 PF02994.12 T236811_1 - 4.3e-13 48.7 0.5 7e-13 48.0 0.5 1.2 1 0 0 1 1 1 1 L1 transposable element AMP-binding PF00501.26 T228735_2 - 9.3e-06 24.3 0.0 1.3e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF1725 PF08333.9 T067424_3 - 0.0025 17.3 0.2 0.0053 16.3 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T031004_1 - 2.2e-50 171.4 0.4 3.1e-50 170.9 0.4 1.1 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T031004_1 - 2.6e-13 49.9 0.0 4.3e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_1 PF01359.16 T031004_1 - 5.7e-07 29.2 0.0 1.3e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) Exo_endo_phos_2 PF14529.4 T031004_1 - 5.3e-06 26.1 1.0 8.8e-06 25.4 1.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T031004_1 - 5.7e-06 26.4 0.0 9.5e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1725 PF08333.9 T031004_2 - 0.00037 19.9 0.3 0.00073 19.0 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVP PF00077.18 T031004_2 - 0.13 12.4 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Transposase_22 PF02994.12 T031004_3 - 3.1e-54 184.1 8.5 5.2e-54 183.4 8.5 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T031004_3 - 1.2e-17 64.0 0.2 5.2e-07 29.3 0.1 3.2 3 0 0 3 3 3 3 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1028 PF06267.10 T258955_1 - 5.2 6.7 6.6 10 5.7 6.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF1028) RVT_1 PF00078.25 T359265_2 - 1e-48 165.7 2.6 1.4e-48 165.3 2.6 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SP_C-Propep PF08999.8 T043272_2 - 2.4 7.9 5.8 5.4 6.7 5.8 1.5 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide zf-AN1 PF01428.14 T235996_1 - 1.8 8.7 6.1 0.17 12.0 0.5 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger PHO4 PF01384.18 T088590_2 - 0.0021 17.0 0.0 0.0021 17.0 0.0 2.7 3 0 0 3 3 3 2 Phosphate transporter family Transposase_1 PF01359.16 T122299_3 - 4.6e-22 77.5 0.2 8.9e-22 76.6 0.2 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_22 PF02994.12 T203337_3 - 3.9e-104 348.3 15.3 7.8e-104 347.3 15.3 1.4 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T203337_3 - 1.6e-33 116.0 0.2 3.1e-33 115.0 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1664 PF07889.10 T203337_3 - 0.017 15.0 4.1 0.6 10.0 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sec34 PF04136.13 T203337_3 - 0.026 14.3 2.0 0.058 13.2 2.0 1.5 1 0 0 1 1 1 0 Sec34-like family Spectrin PF00435.19 T203337_3 - 0.049 14.0 5.6 0.12 12.7 5.6 1.6 1 0 0 1 1 1 0 Spectrin repeat zf-C4H2 PF10146.7 T203337_3 - 0.075 13.2 13.1 0.023 14.8 8.5 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein KLRAQ PF10205.7 T203337_3 - 0.17 12.0 4.4 0.53 10.4 4.4 1.9 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Prominin PF05478.9 T203337_3 - 0.22 9.3 2.5 0.38 8.5 2.5 1.3 1 0 0 1 1 1 0 Prominin DUF16 PF01519.14 T203337_3 - 0.22 11.9 2.7 1.6 9.1 2.8 2.4 1 1 0 1 1 1 0 Protein of unknown function DUF16 Med2 PF11214.6 T203337_3 - 0.52 10.4 6.3 0.2 11.7 2.4 2.4 2 1 0 2 2 2 0 Mediator complex subunit 2 Syntaxin-6_N PF09177.9 T203337_3 - 0.61 10.5 9.5 0.1 13.1 5.2 1.9 2 0 0 2 2 1 0 Syntaxin 6, N-terminal RVT_1 PF00078.25 T351468_2 - 1.4e-22 80.2 1.3 2.2e-22 79.5 1.3 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T351468_2 - 3.2e-10 40.1 0.0 5.3e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T351468_2 - 1.3e-07 31.3 1.1 2.9e-07 30.2 1.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Transposase_22 PF02994.12 T351468_3 - 3.6e-151 503.0 20.2 4.9e-151 502.6 20.2 1.1 1 0 0 1 1 1 1 L1 transposable element KLRAQ PF10205.7 T351468_3 - 0.096 12.8 3.5 0.23 11.6 3.5 1.6 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Seryl_tRNA_N PF02403.20 T351468_3 - 0.18 11.9 5.7 0.31 11.1 5.7 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.12 T351468_3 - 4.3 7.0 8.5 11 5.6 8.5 1.6 1 0 0 1 1 1 0 IncA protein Wbp11 PF09429.8 T094055_3 - 0.077 13.3 8.7 0.18 12.1 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 PRP9_N PF16958.3 T316679_3 - 3.1 7.7 6.4 4.8 7.1 6.4 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus Toxin_13 PF07822.9 T229246_1 - 0.011 15.7 0.3 0.032 14.2 0.3 1.7 1 0 0 1 1 1 0 Neurotoxin B-IV-like protein RNase_H PF00075.22 T062889_1 - 1.3e-13 51.2 0.0 2.2e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 RNase H Transposase_22 PF02994.12 T062889_1 - 6.9e-11 41.5 0.3 1.5e-10 40.3 0.3 1.5 1 0 0 1 1 1 1 L1 transposable element TLV_coat PF00429.17 T062889_2 - 4.7e-34 117.9 3.0 4.7e-34 117.9 3.0 2.2 2 0 0 2 2 2 1 ENV polyprotein (coat polyprotein) DUF1725 PF08333.9 T062889_2 - 4.3e-07 29.3 0.7 1e-06 28.1 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Homeobox PF00046.27 T379419_3 - 0.034 13.8 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 Homeobox domain RNase_H PF00075.22 T172341_3 - 2.1e-05 24.6 0.0 4.1e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T154130_1 - 2.5e-07 30.3 0.1 3.5e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_MA PF01140.17 T154130_1 - 0.00034 20.2 0.6 0.0011 18.5 0.1 2.0 2 0 0 2 2 2 1 Matrix protein (MA), p15 RVP PF00077.18 T154130_1 - 0.011 15.9 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC PF00098.21 T154130_1 - 0.014 15.3 0.1 0.053 13.5 0.1 2.1 1 0 0 1 1 1 0 Zinc knuckle gag-asp_proteas PF13975.4 T154130_1 - 0.033 14.6 0.0 0.056 13.9 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.4 T154130_1 - 0.041 14.4 0.0 0.085 13.4 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease RVT_1 PF00078.25 T154130_3 - 5.8e-19 68.4 0.0 9.1e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3566 PF12089.6 T107058_1 - 0.25 11.6 0.7 0.38 11.0 0.7 1.2 1 0 0 1 1 1 0 Transmembrane domain of unknown function (DUF3566) DUF4770 PF15994.3 T107058_3 - 0.26 11.4 5.1 0.9 9.6 5.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) MIP-T3 PF10243.7 T107058_3 - 7.3 5.0 17.2 13 4.2 17.2 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Gag_p24 PF00607.18 T260187_1 - 2.2e-07 30.8 0.1 3.3e-07 30.2 0.1 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) Gag_p10 PF02337.15 T260187_1 - 5.7e-07 29.2 0.2 1.2e-06 28.2 0.2 1.4 1 0 0 1 1 1 1 Retroviral GAG p10 protein RNase_H PF00075.22 T260187_1 - 0.16 12.0 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 RNase H GP41 PF00517.15 T260187_2 - 1.1e-13 51.4 0.6 1.9e-13 50.6 0.6 1.3 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_env_2 PF13804.4 T260187_3 - 1.4e-39 135.4 0.0 3.1e-39 134.3 0.0 1.6 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein RVT_1 PF00078.25 T260187_3 - 3.7e-29 101.7 0.0 5.4e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.12 T260187_3 - 1.6e-27 94.9 0.1 3.3e-27 93.9 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain IN_DBD_C PF00552.19 T260187_3 - 7.6e-05 21.8 0.0 0.00027 20.0 0.0 1.9 1 0 0 1 1 1 1 Integrase DNA binding domain GP41 PF00517.15 T260187_3 - 0.00056 19.7 1.2 0.00062 19.5 0.0 1.6 2 0 0 2 2 2 1 Retroviral envelope protein RVT_1 PF00078.25 T311041_3 - 5.4e-45 153.5 2.0 9.2e-45 152.7 2.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T311041_3 - 0.0033 17.5 0.0 0.0071 16.5 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CagY_M PF07337.9 T051670_1 - 1.1e-07 31.2 20.2 72 3.0 0.4 13.1 11 3 2 13 13 13 9 DC-EC Repeat CagY_M PF07337.9 T051670_2 - 3.4e-12 45.6 3.5 12 5.5 0.0 11.4 12 0 0 12 12 12 2 DC-EC Repeat SBP_bac_10 PF07596.9 T051670_2 - 4.1 7.1 71.8 1.4 8.7 10.3 9.8 1 1 7 8 8 8 0 Protein of unknown function (DUF1559) CagY_M PF07337.9 T051670_3 - 2.2e-07 30.3 7.0 61 3.2 0.0 9.4 10 0 0 10 10 10 7 DC-EC Repeat Transposase_1 PF01359.16 T351119_1 - 0.027 14.2 0.1 0.082 12.6 0.1 1.7 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_1 PF01359.16 T351119_2 - 5.6e-21 74.1 7.5 1.6e-20 72.6 4.6 2.6 2 0 0 2 2 2 1 Transposase (partial DDE domain) DDE_3 PF13358.4 T351119_2 - 0.003 17.2 0.4 0.0053 16.4 0.4 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BEN PF10523.7 T351119_2 - 0.059 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 BEN domain CCDC144C PF14915.4 T018773_2 - 1.6e-59 201.4 37.8 1.6e-35 122.6 14.1 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018773_2 - 4.2e-07 30.2 8.4 4.2e-07 30.2 8.4 4.0 3 1 1 4 4 4 1 Domain of unknown function (DUF3496) Laminin_II PF06009.10 T018773_2 - 1.4 8.8 13.2 0.026 14.4 1.1 2.5 2 0 0 2 2 2 0 Laminin Domain II CCDC144C PF14915.4 T018773_3 - 1.4e-16 60.4 9.6 2.5e-16 59.6 9.6 1.3 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region BAR_3_WASP_bdg PF10456.7 T018773_3 - 1e-08 34.9 0.3 1.8e-08 34.0 0.3 1.3 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein TPR_16 PF13432.4 T035017_2 - 0.00051 20.5 1.1 13 6.4 0.0 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.4 T035017_3 - 0.0079 16.7 1.0 4.2 8.0 0.1 3.3 2 1 2 4 4 4 3 Tetratricopeptide repeat Mit_proteolip PF08039.9 T001132_3 - 1 9.6 2.8 2 8.7 2.8 1.4 1 0 0 1 1 1 0 Mitochondrial proteolipid RVT_1 PF00078.25 T266278_1 - 9.3e-20 71.0 0.2 1.6e-19 70.2 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T266278_3 - 8.9e-95 317.5 20.5 3.8e-92 308.8 10.8 2.2 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T266278_3 - 5.5e-06 25.7 2.1 1.3e-05 24.5 2.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) HERV-K_REC PF15695.3 T024390_1 - 3.8e-33 113.3 3.7 7e-33 112.4 3.7 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 rve PF00665.24 T024390_1 - 1.7e-13 50.7 0.0 2.8e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain GP41 PF00517.15 T024390_1 - 5.4e-10 39.3 3.6 9.3e-10 38.5 3.6 1.2 1 0 0 1 1 1 1 Retroviral envelope protein DcuC PF03606.13 T024390_1 - 0.16 10.3 0.2 0.23 9.8 0.2 1.1 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier IN_DBD_C PF00552.19 T024390_3 - 2e-06 26.8 1.0 4.1e-06 25.9 1.0 1.5 1 0 0 1 1 1 1 Integrase DNA binding domain CitMHS PF03600.14 T089647_3 - 0.025 13.7 12.7 0.043 12.9 12.7 1.3 1 0 0 1 1 1 0 Citrate transporter IQ PF00612.25 T272760_2 - 0.001 18.5 1.2 0.0049 16.4 0.1 2.5 2 0 0 2 2 2 1 IQ calmodulin-binding motif HERV-K_REC PF15695.3 T272207_1 - 1.3e-05 25.1 0.5 2.2e-05 24.3 0.5 1.3 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 HERV-K_env_2 PF13804.4 T272207_2 - 8.7e-10 38.5 0.2 1.4e-09 37.8 0.2 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein RVP PF00077.18 T272207_3 - 3.2e-17 62.5 0.5 6e-17 61.6 0.1 1.7 2 0 0 2 2 2 1 Retroviral aspartyl protease dUTPase PF00692.17 T272207_3 - 7.5e-14 51.4 0.0 1.4e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 dUTPase G-patch PF01585.21 T272207_3 - 9e-10 38.2 0.8 1.9e-09 37.2 0.8 1.5 1 0 0 1 1 1 1 G-patch domain IN_DBD_C PF00552.19 T272207_3 - 1.2e-07 30.8 1.3 2.2e-07 29.9 1.3 1.4 1 0 0 1 1 1 1 Integrase DNA binding domain Gag_p24 PF00607.18 T272207_3 - 0.008 15.9 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) G-patch_2 PF12656.5 T272207_3 - 0.11 12.4 0.2 0.2 11.7 0.2 1.3 1 0 0 1 1 1 0 G-patch domain ADAM_CR PF08516.10 T106654_2 - 2e-21 76.4 2.8 2e-21 76.4 2.8 3.5 3 1 1 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.21 T106654_2 - 2.5e-16 60.1 26.2 2.5e-16 60.1 26.2 3.3 3 0 0 3 3 3 1 Disintegrin Pep_M12B_propep PF01562.17 T106654_3 - 1.9e-16 60.4 0.0 4.2e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.17 T106654_3 - 4.8e-15 55.9 0.5 7.7e-15 55.2 0.5 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 T106654_3 - 0.0059 16.6 0.8 0.0097 15.9 0.8 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T106654_3 - 0.0061 16.9 0.2 0.011 16.1 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T106654_3 - 0.14 11.7 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like RVT_1 PF00078.25 T327296_1 - 2.9e-52 177.3 1.5 5.2e-52 176.4 1.5 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T327296_1 - 1.7e-34 119.2 2.7 1.7e-20 73.1 0.8 2.4 2 0 0 2 2 2 2 L1 transposable element Exo_endo_phos PF03372.21 T327296_2 - 0.0065 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T327296_3 - 3.3e-30 105.1 9.6 2.2e-28 99.0 1.9 2.4 2 0 0 2 2 2 2 L1 transposable element UBD PF16455.3 T327296_3 - 0.19 11.9 2.3 0.57 10.3 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-binding domain Med19 PF10278.7 T117619_1 - 6.4 6.5 10.4 11 5.8 10.4 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 RNase_H PF00075.22 T315958_1 - 4.2e-17 62.6 0.0 6.2e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 RNase H rve PF00665.24 T315958_1 - 3.2e-09 36.9 0.0 5.2e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.18 T315958_3 - 0.0018 18.4 0.0 0.0031 17.6 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.21 T315958_3 - 0.0038 17.1 3.0 0.036 14.0 0.5 2.8 2 0 0 2 2 2 1 Zinc knuckle RVT_1 PF00078.25 T315958_3 - 0.005 16.2 0.0 0.0077 15.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) eIF3g PF12353.6 T315958_3 - 1.3 9.3 3.3 0.81 9.9 1.4 1.5 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G DUF1725 PF08333.9 T357416_2 - 4e-07 29.4 1.3 4e-07 29.4 1.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) DUF2237 PF09996.7 T124748_1 - 0.0013 18.6 7.4 8.3 6.3 0.1 4.7 4 1 1 5 5 5 3 Uncharacterized protein conserved in bacteria (DUF2237) DUF1889 PF08986.8 T124748_1 - 0.059 13.7 0.0 47 4.3 0.0 4.1 1 1 3 6 6 6 0 Domain of unknown function (DUF1889) Orexin PF02072.13 T124748_1 - 3.6 7.4 23.2 1.6 8.5 0.6 4.6 2 1 2 5 5 5 0 Prepro-orexin DUF2237 PF09996.7 T124748_2 - 0.0024 17.7 7.0 9.1 6.2 0.0 5.0 3 2 2 6 6 6 4 Uncharacterized protein conserved in bacteria (DUF2237) Orexin PF02072.13 T124748_2 - 0.085 12.7 16.3 0.35 10.7 2.3 4.1 1 1 3 4 4 4 0 Prepro-orexin DUF2237 PF09996.7 T124748_3 - 0.0026 17.6 5.5 23 4.9 0.0 5.1 3 1 2 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2237) DUF1950 PF09187.8 T124748_3 - 0.0099 15.8 1.3 28 4.7 0.0 3.9 1 1 4 5 5 5 0 Domain of unknown function(DUF1950) DUF1889 PF08986.8 T124748_3 - 0.11 12.7 0.0 33 4.8 0.0 3.5 2 1 1 4 4 4 0 Domain of unknown function (DUF1889) Orexin PF02072.13 T124748_3 - 0.22 11.4 21.2 0.77 9.6 1.6 4.0 2 2 2 4 4 4 0 Prepro-orexin DUF2393 PF09624.8 T124748_3 - 0.42 10.3 1.3 41 3.9 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2393) DUF2706 PF10913.6 T124748_3 - 0.64 9.8 11.4 24 4.7 0.0 5.2 6 0 0 6 6 6 0 Protein of unknown function (DUF2706) DUF1151 PF06625.9 T124748_3 - 2 8.3 11.5 12 5.8 0.5 4.3 3 2 0 3 3 3 0 Protein of unknown function (DUF1151) FAM27 PF15832.3 T215850_3 - 9.4e-36 122.1 24.5 9.4e-36 122.1 24.5 4.1 4 0 0 4 4 4 1 FAM27 D and E protein family DUF765 PF05570.9 T228196_2 - 7.4 6.7 71.8 8.5 6.5 4.3 8.5 7 0 0 7 7 7 0 Circovirus protein of unknown function (DUF765) Transposase_22 PF02994.12 T093086_1 - 1.9e-30 105.8 14.9 5.5e-28 97.7 8.2 3.0 2 1 0 2 2 2 2 L1 transposable element Transposase_1 PF01359.16 T093086_2 - 4.7e-20 71.1 0.5 9.6e-20 70.1 0.5 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_22 PF02994.12 T093086_2 - 2.7e-11 42.8 0.0 3.8e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 L1 transposable element HTH_24 PF13412.4 T093086_3 - 0.047 13.1 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Chal_sti_synt_N PF00195.17 T093086_3 - 0.079 12.2 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Chalcone and stilbene synthases, N-terminal domain CaKB PF03185.13 T052060_1 - 9.4 5.7 10.1 3.6 7.1 7.3 1.7 1 1 0 2 2 2 0 Calcium-activated potassium channel, beta subunit PH_6 PF15406.4 T315126_1 - 0.18 11.9 0.0 0.33 11.1 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain Gallidermin PF02052.13 T100217_3 - 1.5e-06 28.3 0.6 1.9 8.7 0.0 4.4 4 0 0 4 4 4 3 Gallidermin DUF2484 PF10658.7 T183050_3 - 0.046 13.9 0.2 14 5.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2484) DUF4632 PF15451.4 T337640_3 - 0.053 13.5 0.1 0.15 12.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) Toxin_13 PF07822.9 T229245_1 - 0.027 14.5 0.3 0.027 14.5 0.3 2.0 2 0 0 2 2 2 0 Neurotoxin B-IV-like protein TMEM191C PF15194.4 T230011_1 - 3.7e-27 94.7 8.0 6.1e-27 94.0 8.0 1.3 1 0 0 1 1 1 1 TMEM191C family TMEM191C PF15194.4 T230011_2 - 2.2e-12 47.0 0.1 4.5e-12 46.0 0.1 1.4 1 0 0 1 1 1 1 TMEM191C family DUF812 PF05667.9 T012274_2 - 6.9 5.3 8.5 9.6 4.8 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) RVT_1 PF00078.25 T012473_1 - 7.2e-07 28.8 3.0 2e-06 27.4 0.0 2.4 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T012473_2 - 3.6e-07 29.8 0.1 5.8e-07 29.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T012473_3 - 7.8e-07 28.5 0.2 1.5e-06 27.5 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T292094_3 - 5e-43 147.0 2.3 7.6e-43 146.4 2.3 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MIP-T3 PF10243.7 T069991_1 - 2.8 6.4 81.0 4 5.9 81.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Homeobox PF00046.27 T379418_2 - 0.023 14.4 0.0 0.066 12.9 0.0 1.7 2 0 0 2 2 2 0 Homeobox domain Peptidase_S49_N PF08496.8 T188410_2 - 3.5 7.6 5.6 6.9 6.6 5.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal V-set PF07686.15 T248997_1 - 2.7e-07 30.6 0.6 1.4e-06 28.3 0.0 2.4 2 1 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.14 T248997_1 - 0.0062 16.4 0.1 0.11 12.4 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 T248997_1 - 0.019 15.0 0.9 0.18 11.9 0.1 2.6 2 1 0 2 2 2 0 Immunoglobulin domain TMEM247 PF15444.4 T124751_2 - 0.022 14.7 0.2 0.022 14.7 0.2 1.6 2 0 0 2 2 2 0 Transmembrane protein 247 Tektin PF03148.12 T124751_3 - 0.0024 16.6 0.1 0.0031 16.2 0.1 1.0 1 0 0 1 1 1 1 Tektin family zf-RING_UBOX PF13445.4 T208524_1 - 6e-08 32.4 0.6 6e-08 32.4 0.6 3.7 5 0 0 5 5 5 1 RING-type zinc-finger zf-RING_5 PF14634.4 T208524_1 - 3.1e-07 30.1 3.8 3.1e-07 30.1 3.8 3.5 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 T208524_1 - 4.4e-05 23.4 0.5 4.4e-05 23.4 0.5 3.6 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 T208524_1 - 0.00035 20.2 1.4 0.00035 20.2 1.4 3.2 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 T208524_1 - 0.00038 20.5 8.8 0.00038 20.5 8.8 3.9 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 T208524_1 - 0.00068 19.3 1.9 0.00068 19.3 1.9 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) RVT_1 PF00078.25 T253257_1 - 3.6e-23 82.1 0.0 5.9e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T253257_1 - 9.7e-14 51.3 0.0 1.9e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T253257_1 - 1.6e-06 28.2 0.6 2.3e-05 24.4 0.6 2.4 1 1 0 1 1 1 1 Retroviral aspartyl protease RNase_H PF00075.22 T253257_1 - 0.00048 20.2 0.0 0.00093 19.3 0.0 1.3 1 0 0 1 1 1 1 RNase H Asp_protease_2 PF13650.4 T253257_1 - 0.023 15.3 0.1 0.047 14.3 0.1 1.4 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.21 T253257_1 - 0.037 14.0 2.5 0.088 12.8 2.5 1.7 1 0 0 1 1 1 0 Zinc knuckle gag-asp_proteas PF13975.4 T253257_1 - 0.054 13.9 0.2 0.11 12.9 0.2 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Gag_MA PF01140.17 T253257_2 - 1.9e-14 53.3 0.1 1.9e-14 53.3 0.1 1.9 2 0 0 2 2 2 1 Matrix protein (MA), p15 Gag_p30 PF02093.14 T253257_3 - 4.3e-28 98.1 0.3 6.2e-28 97.6 0.3 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Colipase-like PF15083.4 T090352_2 - 1.1e-32 111.8 10.9 2.1e-32 111.0 10.9 1.4 1 0 0 1 1 1 1 Colipase-like Colipase PF01114.16 T090352_2 - 6.6 6.4 10.9 3.8 7.1 1.8 2.8 2 0 0 2 2 2 0 Colipase, N-terminal domain Colipase-like PF15083.4 T090352_3 - 1.8e-11 43.9 2.3 3.5e-11 43.0 2.3 1.4 1 0 0 1 1 1 1 Colipase-like RNase_H PF00075.22 T089159_2 - 6.7e-15 55.4 0.1 1.1e-14 54.7 0.1 1.3 1 0 0 1 1 1 1 RNase H TLV_coat PF00429.17 T089159_2 - 2.5e-12 46.1 0.3 2.5e-12 46.1 0.3 1.9 2 0 0 2 2 2 1 ENV polyprotein (coat polyprotein) Gag_p30 PF02093.14 T089159_3 - 2.8e-14 53.0 0.0 4.3e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T089159_3 - 4.2e-07 29.6 0.0 7.5e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T089159_3 - 8.6e-06 25.5 1.0 2.2e-05 24.2 1.0 1.8 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.18 T089159_3 - 0.00049 20.2 0.0 0.00088 19.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_5 PF14787.4 T089159_3 - 0.056 13.0 2.7 0.12 12.0 2.7 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Transposase_22 PF02994.12 T103732_3 - 2.1e-142 474.2 20.5 2.9e-142 473.8 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103732_3 - 0.03 14.5 0.0 0.056 13.6 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103732_3 - 0.059 13.0 10.5 0.11 12.2 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103732_3 - 0.06 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103732_3 - 0.34 11.4 5.0 0.69 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103732_3 - 0.42 9.8 12.3 0.74 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103732_3 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103732_3 - 3 8.0 7.5 5.3 7.2 6.7 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein DUF2116 PF09889.7 T291761_1 - 0.032 14.1 2.1 0.032 14.1 0.2 2.1 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) BBP2_2 PF10082.7 T185623_2 - 3.2 6.3 6.2 9.1 4.9 0.3 1.9 1 1 1 2 2 2 0 Putative beta-barrel porin 2 TetR_C_12 PF16914.3 T185623_2 - 7.8 6.5 12.4 22 5.1 0.2 3.6 1 1 5 6 6 6 0 Bacterial transcriptional repressor C-terminal SERTA PF06031.11 T105652_3 - 1.4e-12 46.9 2.8 1.4e-12 46.9 2.8 1.8 2 0 0 2 2 2 1 SERTA motif UPF0730 PF15827.3 T105652_3 - 8.9e-12 44.9 3.0 8.9e-12 44.9 3.0 2.2 2 0 0 2 2 2 1 UPF0730 unknown protein family rve PF00665.24 T157617_1 - 6e-09 36.0 0.0 9.2e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain dUTPase PF00692.17 T157617_1 - 6.5e-05 22.5 0.0 0.00011 21.8 0.0 1.2 1 0 0 1 1 1 1 dUTPase RNase_H PF00075.22 T157617_3 - 1.9e-08 34.5 0.2 3.1e-08 33.8 0.2 1.2 1 0 0 1 1 1 1 RNase H ADAM_CR PF08516.10 T106653_2 - 1.6e-21 76.7 2.8 1.6e-21 76.7 2.8 3.6 3 2 2 5 5 5 1 ADAM cysteine-rich Disintegrin PF00200.21 T106653_2 - 2.1e-16 60.4 26.2 2.1e-16 60.4 26.2 3.3 3 0 0 3 3 3 1 Disintegrin Pep_M12B_propep PF01562.17 T106653_3 - 1.5e-16 60.8 0.0 3.4e-16 59.6 0.0 1.6 2 0 0 2 2 2 1 Reprolysin family propeptide Reprolysin PF01421.17 T106653_3 - 3.9e-15 56.2 0.5 6.2e-15 55.5 0.5 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 T106653_3 - 0.0049 16.9 0.8 0.0082 16.2 0.8 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 T106653_3 - 0.0049 17.2 0.2 0.0091 16.4 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 T106653_3 - 0.11 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_S49_N PF08496.8 T188418_2 - 2.5 8.0 5.6 4.4 7.3 5.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF2722 PF10846.6 T198267_1 - 0.05 12.4 15.6 0.081 11.7 15.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Suf PF05843.12 T198267_1 - 1.7 8.4 9.0 2.8 7.7 9.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spt20 PF12090.6 T198267_1 - 2.2 7.7 25.8 3.7 6.9 25.8 1.3 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.11 T198267_1 - 5.5 6.7 22.1 9.9 5.9 22.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Chorion_2 PF03964.13 T198267_2 - 0.41 11.4 5.3 0.69 10.6 5.3 1.3 1 0 0 1 1 1 0 Chorion family 2 RVT_1 PF00078.25 T163778_1 - 1.4e-13 50.7 1.3 2.6e-13 49.9 1.3 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1664 PF07889.10 T163778_2 - 3.9 7.4 7.7 1 9.2 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sas10_Utp3 PF04000.13 T163778_2 - 7.2 7.2 6.6 4.9 7.7 1.3 2.5 2 0 0 2 2 2 0 Sas10/Utp3/C1D family Transposase_22 PF02994.12 T163778_3 - 8.7e-52 176.1 2.4 1.4e-51 175.4 2.4 1.2 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T163778_3 - 3.4e-14 52.8 0.1 5.2e-14 52.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Toxin_13 PF07822.9 T229250_2 - 0.029 14.4 0.3 0.029 14.4 0.3 2.0 2 0 0 2 2 2 0 Neurotoxin B-IV-like protein Transposase_22 PF02994.12 T080932_3 - 2.4e-88 296.4 18.7 1.3e-87 294.0 18.7 2.0 1 1 0 1 1 1 1 L1 transposable element Adaptin_binding PF10199.7 T080932_3 - 0.045 14.2 4.3 0.11 12.9 4.3 1.6 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 ArAE_2_N PF10337.7 T080932_3 - 0.12 11.3 2.0 0.17 10.8 2.0 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Syntaxin-6_N PF09177.9 T080932_3 - 0.15 12.5 9.7 0.14 12.6 5.8 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal XhlA PF10779.7 T080932_3 - 3.2 7.9 7.7 0.99 9.5 2.3 2.6 2 0 0 2 2 2 0 Haemolysin XhlA DUF1725 PF08333.9 T357406_2 - 5.3e-07 29.0 1.3 5.3e-07 29.0 1.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) Orn_DAP_Arg_deC PF00278.20 T007021_1 - 7e-11 42.1 0.0 1.2e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Orn_Arg_deC_N PF02784.14 T007021_2 - 5.1e-05 22.8 0.0 7.2e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain RNase_H PF00075.22 T294832_1 - 5.7e-22 78.3 0.0 9e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 RNase H zf-H2C2 PF09337.8 T294832_1 - 1.4e-07 31.6 0.1 3e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve PF00665.24 T294832_1 - 6.5e-05 23.0 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.25 T294832_2 - 1.1e-19 70.7 0.0 2.6e-19 69.5 0.0 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.25 T004824_1 - 3e-21 75.8 0.0 4.1e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T004824_2 - 6.8e-19 68.1 1.7 4.2e-16 59.0 0.8 2.1 2 0 0 2 2 2 2 Gag P30 core shell protein Gag_MA PF01140.17 T004824_2 - 6.3e-13 48.4 0.3 1.6e-12 47.1 0.0 1.8 2 0 0 2 2 2 1 Matrix protein (MA), p15 RNase_H PF00075.22 T004824_3 - 3.6e-19 69.2 0.0 8.4e-19 68.0 0.0 1.5 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T004824_3 - 7.5e-15 54.9 0.0 1.2e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T004824_3 - 7.7e-11 42.0 0.0 1.6e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.21 T189085_2 - 0.63 10.1 14.0 0.23 11.5 10.1 2.4 2 0 0 2 2 2 0 Zinc knuckle TLV_coat PF00429.17 T189085_3 - 1.1e-51 176.1 3.0 1.6e-51 175.6 3.0 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) DUF3809 PF12723.5 T182999_3 - 0.032 14.4 0.1 3.5e+02 1.3 0.0 5.6 3 3 4 8 8 8 0 Protein of unknown function (DUF3809) Transposase_22 PF02994.12 T064376_1 - 2.3e-22 79.2 0.5 3.6e-22 78.6 0.5 1.1 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T346741_1 - 4.1e-35 121.2 1.9 7.1e-35 120.4 1.9 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T346741_1 - 5.7e-14 51.6 14.6 2.8e-07 29.6 2.9 2.2 2 0 0 2 2 2 2 L1 transposable element HSBP1 PF06825.10 T346741_1 - 0.028 14.2 0.1 0.063 13.1 0.1 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Transposase_22 PF02994.12 T346741_3 - 6e-64 216.1 8.9 2.1e-57 194.5 5.4 2.2 2 0 0 2 2 2 2 L1 transposable element DUF1725 PF08333.9 T080918_1 - 2.1e-07 30.2 0.6 4.9e-07 29.1 0.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T080918_1 - 4.3e-07 29.5 0.5 6.8e-07 28.9 0.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T080918_2 - 1.8e-108 362.6 16.9 3.8e-108 361.5 16.9 1.5 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T080918_2 - 9.5e-30 103.6 0.6 1.8e-29 102.7 0.6 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.21 T080918_2 - 1.5e-09 38.0 0.0 3.2e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T080918_2 - 4.8e-06 26.3 1.8 1.2e-05 25.1 1.8 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF1325 PF07039.9 T129489_3 - 0.066 13.2 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 SGF29 tudor-like domain Transposase_22 PF02994.12 T276721_3 - 0.011 14.5 0.0 0.017 13.9 0.0 1.1 1 0 0 1 1 1 0 L1 transposable element DUF1725 PF08333.9 T320359_1 - 0.00021 20.7 6.5 0.0011 18.4 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1725) RVT_1 PF00078.25 T320359_3 - 4.2e-27 95.0 0.0 6.8e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T069166_1 - 2.9e-21 75.8 0.0 5.4e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T069166_1 - 9.9e-21 74.3 0.0 1.4e-20 73.8 0.0 1.2 1 0 0 1 1 1 1 RNase H TLV_coat PF00429.17 T069166_1 - 3.7e-16 58.8 3.4 5.6e-16 58.2 3.4 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) RVP PF00077.18 T069166_1 - 0.00047 20.3 0.0 0.00096 19.3 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_3 PF13456.4 T069166_1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like TLV_coat PF00429.17 T069166_2 - 3e-21 75.6 9.0 3.9e-16 58.7 3.0 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) RVT_1 PF00078.25 T069166_3 - 2e-11 43.7 0.1 3.3e-11 43.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2207 PF09972.7 T153290_1 - 0.076 11.6 2.7 0.19 10.3 2.7 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RNA_pol_3_Rpc31 PF11705.6 T153290_1 - 2.4 8.2 16.7 4.1 7.4 16.7 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CYLD_phos_site PF16607.3 T257541_1 - 4.8 6.9 21.2 9.3 5.9 0.8 4.5 4 1 1 5 5 5 0 Phosphorylation region of CYLD, unstructured CYLD_phos_site PF16607.3 T257541_2 - 4.7 6.9 8.2 14 5.3 0.3 3.1 3 0 0 3 3 3 0 Phosphorylation region of CYLD, unstructured Pentapeptide_2 PF01469.16 T051532_3 - 0.0055 16.4 6.3 0.51 10.1 1.1 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Transposase_22 PF02994.12 T276726_3 - 0.01 14.6 0.0 0.016 14.0 0.0 1.1 1 0 0 1 1 1 0 L1 transposable element UPAR_LY6 PF00021.19 T176633_2 - 3.2e-05 24.4 34.1 0.00088 19.8 5.5 4.5 4 0 0 4 4 4 3 u-PAR/Ly-6 domain DUF1480 PF07351.11 T176633_2 - 3.3 7.9 6.5 11 6.2 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1480) Gallidermin PF02052.13 T100219_2 - 1.2e-06 28.6 0.6 1.8 8.8 0.0 4.4 4 0 0 4 4 4 3 Gallidermin AAA_9 PF12781.5 T353757_1 - 5e-06 25.7 0.0 8.6e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 Epiglycanin_C PF14654.4 T300727_2 - 9.3e-05 22.3 0.3 0.0014 18.5 0.1 2.4 2 0 0 2 2 2 1 Mucin, catalytic, TM and cytoplasmic tail region DUF1725 PF08333.9 T212573_2 - 0.043 13.4 0.1 0.099 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) DUF1678 PF07913.9 T212573_3 - 5.5 6.6 10.3 3.4 7.3 0.2 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1678) LEA_1 PF03760.13 T106771_2 - 2.9 8.5 4.0 1.2 9.7 0.2 2.1 2 0 0 2 2 2 0 Late embryogenesis abundant (LEA) group 1 SoxG PF04268.10 T173076_1 - 0.046 13.7 0.1 0.069 13.2 0.1 1.3 1 0 0 1 1 1 0 Sarcosine oxidase, gamma subunit family DUF4519 PF15012.4 T166068_3 - 0.11 12.6 0.1 0.11 12.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) PIRT PF15099.4 T316884_3 - 0.019 14.4 0.5 47 3.4 0.1 3.5 3 1 1 4 4 4 0 Phosphoinositide-interacting protein family dUTPase PF00692.17 T271918_1 - 3e-08 33.3 0.0 5.2e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 dUTPase RVT_1 PF00078.25 T271918_1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T271918_3 - 6.3e-07 29.6 1.2 9.9e-07 28.9 1.2 1.2 1 0 0 1 1 1 1 RNase H rve PF00665.24 T271918_3 - 0.00061 19.9 0.0 0.0012 18.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain GAIN PF16489.3 T229039_1 - 2.6e-10 39.9 0.0 3.8e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.19 T229039_1 - 5.2e-06 26.9 2.4 4.1e-05 24.0 1.4 2.8 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif GFO_IDH_MocA_C PF02894.15 T001702_2 - 0.12 12.3 0.0 0.32 10.9 0.0 1.6 2 0 0 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain DUF3809 PF12723.5 T182996_3 - 0.03 14.5 0.2 3.3e+02 1.4 0.0 5.7 3 3 5 8 8 8 0 Protein of unknown function (DUF3809) zf-H2C2_2 PF13465.4 T194079_1 - 1.1e-75 246.8 71.7 1.6e-08 34.5 0.5 12.0 12 0 0 12 12 12 10 Zinc-finger double domain zf-C2H2 PF00096.24 T194079_1 - 6.3e-55 180.6 68.6 1.5e-06 28.2 2.1 11.2 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T194079_1 - 2.6e-24 83.6 66.4 0.0028 18.2 1.2 11.6 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T194079_1 - 1.1e-12 47.4 60.1 0.0038 17.0 1.5 11.0 10 0 0 10 10 10 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 T194079_1 - 5.5e-07 29.5 48.1 0.045 13.7 2.7 6.8 3 2 4 8 8 8 7 Zinc ribbon domain XPA_N PF01286.16 T194079_1 - 1.7e-05 24.6 41.8 1.3 9.0 0.2 10.6 10 0 0 10 10 10 4 XPA protein N-terminal zf-C2H2_11 PF16622.3 T194079_1 - 0.31 10.7 42.4 0.61 9.8 0.7 9.2 9 0 0 9 9 9 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 T194079_1 - 0.54 10.9 41.7 0.32 11.6 3.6 5.5 1 1 4 5 5 5 0 zinc-ribbon family PH PF00169.27 T130235_3 - 9.6e-12 45.2 0.0 1.5e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 PH domain TMEM191C PF15194.4 T229999_1 - 2.1e-12 47.1 0.0 6e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 TMEM191C family DUF1664 PF07889.10 T229999_1 - 2.8 7.8 4.5 1.9 8.3 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF883 PF05957.11 T229999_1 - 3.8 8.0 9.4 8.6 6.9 9.4 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Syntaxin-6_N PF09177.9 T229999_1 - 6.8 7.2 10.6 0.89 10.0 4.7 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal CALCOCO1 PF07888.9 T229999_1 - 7.2 4.9 26.8 10 4.4 26.8 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like TMEM191C PF15194.4 T229999_3 - 6.2e-27 94.0 8.0 1.1e-26 93.2 8.0 1.3 1 0 0 1 1 1 1 TMEM191C family RVT_1 PF00078.25 T121534_2 - 2.7e-38 131.6 4.1 5e-38 130.7 4.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T121534_2 - 8.1e-08 31.6 0.5 1.7e-07 30.5 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Psm4 PF17063.3 T121534_2 - 2 9.1 4.6 0.55 10.8 0.2 2.3 2 0 0 2 2 2 0 Phenol-soluble modulin alpha 4 peptide Transposase_22 PF02994.12 T121534_3 - 2.1e-76 257.1 11.3 1.1e-72 244.8 6.8 2.2 2 0 0 2 2 2 2 L1 transposable element DUF4705 PF15788.3 T323205_1 - 3.4e-53 177.5 439.7 1.3e-08 34.8 6.9 39.8 20 11 17 38 38 38 25 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323205_2 - 1.9e-88 290.4 441.5 2.9e-17 62.5 8.0 43.5 22 13 14 36 36 36 32 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323205_3 - 2e-69 229.4 466.0 1.1e-15 57.5 9.2 42.6 24 11 11 35 35 35 26 Domain of unknown function (DUF4705) Ntox1 PF15500.4 T139338_3 - 0.13 12.5 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 Putative RNase-like toxin, toxin_1 Dynein_heavy PF03028.13 T085624_1 - 2.1e-12 46.0 0.0 3.2e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor TfoX_N PF04993.11 T165128_1 - 5.1 7.3 31.4 16 5.6 0.9 6.8 1 1 4 5 5 5 0 TfoX N-terminal domain PELOTA_1 PF15608.4 T165128_2 - 1.2 8.9 31.3 7.9 6.3 0.6 7.7 1 1 8 10 10 10 0 PELOTA RNA binding domain BrkDBD PF09607.8 T364948_1 - 0.083 12.6 2.2 0.15 11.7 2.2 1.4 1 0 0 1 1 1 0 Brinker DNA-binding domain RVT_1 PF00078.25 T226505_2 - 0.037 13.4 0.0 0.06 12.7 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T226505_3 - 1.8e-12 47.1 0.0 2.6e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein DUF1725 PF08333.9 T316023_3 - 1.3e-07 30.9 1.5 1.3e-07 30.9 1.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) Herpes_BLLF1 PF05109.11 T316023_3 - 0.00029 18.9 25.0 0.00043 18.3 25.0 1.1 1 0 0 1 1 1 1 Herpes virus major outer envelope glycoprotein (BLLF1) RuvB_C PF05491.11 T332101_1 - 0.2 11.4 0.2 0.33 10.7 0.2 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB C-terminus RVT_1 PF00078.25 T310721_3 - 7.9e-47 159.5 1.6 1.1e-46 159.0 1.6 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HTH_5 PF01022.18 T309066_1 - 0.0021 17.7 0.0 0.0054 16.4 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DDE_3 PF13358.4 T309066_1 - 0.0031 17.2 0.0 0.0058 16.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Fe_dep_repress PF01325.17 T309066_1 - 0.068 13.3 0.0 0.3 11.2 0.0 1.9 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain MarR_2 PF12802.5 T309066_1 - 0.14 11.9 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 MarR family Transposase_1 PF01359.16 T309066_3 - 3.3e-22 78.0 0.0 7.5e-22 76.9 0.0 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) RVT_1 PF00078.25 T171408_2 - 4.6e-20 72.0 0.0 7.2e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T171408_2 - 1.2e-16 61.1 0.0 2.1e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 RNase H rve PF00665.24 T171408_2 - 1.4e-16 60.6 0.0 2.7e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.18 T171408_2 - 9e-15 54.7 0.0 1.7e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.8 T171408_2 - 2e-08 34.2 1.1 5.2e-08 32.9 1.1 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Asp_protease_2 PF13650.4 T171408_2 - 0.0064 17.0 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.4 T171408_2 - 0.013 16.0 0.0 0.022 15.1 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Gag_p30 PF02093.14 T171408_3 - 5e-51 173.1 1.7 7e-51 172.6 1.7 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_MA PF01140.17 T171408_3 - 1.6e-24 85.9 0.2 3.5e-24 84.8 0.2 1.5 1 0 0 1 1 1 1 Matrix protein (MA), p15 Atrophin-1 PF03154.13 T132416_3 - 2.3 6.3 16.4 3.4 5.7 16.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family MIP-T3 PF10243.7 T132416_3 - 9.8 4.6 9.2 14 4.1 9.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 GP41 PF00517.15 T202692_2 - 4.2e-10 39.7 0.3 7.5e-10 38.9 0.3 1.3 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_env_2 PF13804.4 T202692_3 - 4.2e-37 127.4 0.2 6.5e-37 126.8 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein RNase_H PF00075.22 T172343_3 - 8.9e-17 61.5 0.0 1.7e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 RNase H zf-H2C2 PF09337.8 T172343_3 - 3.1e-05 24.0 0.3 8.2e-05 22.7 0.3 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger CDC45 PF02724.12 T155140_1 - 1.2 7.2 6.1 1.8 6.6 6.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Gag_p30 PF02093.14 T260947_2 - 2.6e-14 53.1 0.2 3.4e-14 52.7 0.2 1.1 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p30 PF02093.14 T260947_3 - 1.9e-10 40.5 0.0 2.4e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.18 T260947_3 - 0.0081 15.9 0.0 0.0093 15.7 0.0 1.1 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) CENP-B_dimeris PF09026.8 T102656_3 - 0.19 12.0 0.1 0.36 11.1 0.1 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain WAP PF00095.19 T073912_1 - 0.00035 20.8 11.8 0.0029 17.8 11.8 2.2 1 1 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Sex_peptide PF08138.9 T214292_1 - 4.8 7.3 7.8 2.8 8.0 0.9 2.7 2 1 1 3 3 3 0 Sex peptide (SP) family RVT_1 PF00078.25 T213222_1 - 1.1e-12 47.9 2.0 2e-12 47.0 2.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T213222_2 - 1.2e-79 267.8 3.7 1.2e-79 267.8 3.7 1.9 3 0 0 3 3 3 1 L1 transposable element RVT_1 PF00078.25 T213222_2 - 2.9e-05 23.6 0.0 5.3e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T213222_3 - 3e-08 33.0 0.4 7.2e-08 31.8 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Zn_Tnp_IS91 PF14319.4 T213222_3 - 1.4e-06 27.8 1.2 2.6e-06 26.9 1.2 1.4 1 0 0 1 1 1 1 Transposase zinc-binding domain Ank_5 PF13857.4 T353745_1 - 0.00016 21.8 0.0 0.003 17.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 T353745_1 - 0.00069 20.0 0.0 0.0015 18.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T353745_1 - 0.025 15.0 0.0 0.058 13.9 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.4 T353745_1 - 0.036 14.5 0.0 2.5 8.8 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeat Ank PF00023.28 T353745_1 - 0.087 13.2 0.1 15 6.1 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeat DUF3704 PF12488.6 T353745_2 - 1.1 8.9 5.1 3.4 7.3 5.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) IQ PF00612.25 T272759_1 - 0.0038 16.8 2.4 0.0062 16.1 0.1 2.4 2 0 0 2 2 2 1 IQ calmodulin-binding motif RVT_1 PF00078.25 T239477_1 - 1.7e-51 174.8 1.8 3e-51 173.9 1.8 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.4 T239477_1 - 0.0067 15.9 0.3 0.014 14.9 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4417) YlbE PF14003.4 T239477_1 - 0.79 10.1 0.0 0.79 10.1 0.0 3.0 3 0 0 3 3 3 0 YlbE-like protein CCDC144C PF14915.4 T018816_1 - 2.8e-30 105.4 13.6 2.8e-30 105.4 13.6 4.3 4 0 0 4 4 4 2 CCDC144C protein coiled-coil region Laminin_II PF06009.10 T018816_1 - 0.0029 17.5 1.1 0.0029 17.5 1.1 3.4 4 1 0 4 4 4 1 Laminin Domain II CCDC144C PF14915.4 T018816_2 - 7.6e-08 31.7 3.0 1.1e-07 31.2 3.0 1.2 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region CCDC144C PF14915.4 T018816_3 - 6.9e-30 104.1 16.4 6.9e-30 104.1 16.4 2.0 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018816_3 - 1.7e-16 60.4 6.5 1.7e-16 60.4 6.5 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3496) CCDC-167 PF15188.4 T018816_3 - 1.3 9.2 12.1 1.6 9.0 0.6 2.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 betaPIX_CC PF16523.3 T018816_3 - 1.6 8.4 18.2 1.6 8.4 2.7 3.1 2 1 1 3 3 3 0 betaPIX coiled coil Gag_p30 PF02093.14 T288100_1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein RVP PF00077.18 T288100_3 - 7.3e-05 22.9 0.0 0.00016 21.8 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Wbp11 PF09429.8 T094029_3 - 0.09 13.0 8.7 0.19 12.0 8.7 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 PHO4 PF01384.18 T088591_2 - 0.002 17.1 0.0 0.002 17.1 0.0 2.7 3 0 0 3 3 3 2 Phosphate transporter family AAA_9 PF12781.5 T353750_2 - 5.6e-06 25.5 0.0 1.1e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 PELOTA_1 PF15608.4 T165123_2 - 1 9.1 46.8 2.6 7.9 0.5 10.6 1 1 11 12 12 12 0 PELOTA RNA binding domain RVT_1 PF00078.25 T171405_2 - 1.9e-20 73.2 0.0 3.1e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.22 T171405_2 - 4.8e-17 62.3 0.0 9.5e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 RNase H rve PF00665.24 T171405_2 - 1.6e-16 60.4 0.0 3.8e-16 59.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.8 T171405_2 - 8.9e-09 35.4 1.1 2.5e-08 33.9 1.1 1.9 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger MgtE_N PF03448.15 T164821_3 - 0.00097 19.6 0.0 0.0017 18.8 0.0 1.3 1 0 0 1 1 1 1 MgtE intracellular N domain Transposase_22 PF02994.12 T236132_1 - 0.001 17.9 0.0 0.0016 17.2 0.0 1.1 1 0 0 1 1 1 1 L1 transposable element Imm35 PF15567.4 T123584_2 - 0.021 14.8 0.4 27 4.9 0.0 4.8 5 0 0 5 5 5 0 Immunity protein 35 GATase_7 PF13537.4 T383211_1 - 7.1e-10 38.7 0.0 1.1e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.4 T383211_1 - 2.6e-05 24.3 0.0 4.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Lamprin PF06403.9 T260635_1 - 2.3 8.0 7.6 5.5 6.8 7.6 1.6 1 0 0 1 1 1 0 Lamprin HERV-K_env_2 PF13804.4 T354542_2 - 2.4e-47 160.7 0.2 4.3e-47 159.9 0.2 1.4 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_REC PF15695.3 T354542_2 - 1.6e-44 149.8 7.9 1.6e-44 149.8 7.9 1.9 2 0 0 2 2 2 1 Rec (regulator of expression encoded by corf) of HERV-K-113 LEA_1 PF03760.13 T106778_1 - 2.9 8.5 4.0 1.2 9.7 0.2 2.1 2 0 0 2 2 2 0 Late embryogenesis abundant (LEA) group 1 Epiglycanin_C PF14654.4 T300734_1 - 3.5e-09 36.5 0.7 7.2e-09 35.5 0.7 1.5 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region Mucin-like PF16058.3 T300734_1 - 2.1e-06 27.6 4.4 4.9e-06 26.4 4.4 1.6 1 0 0 1 1 1 1 Mucin-like Mucin-like PF16058.3 T300734_3 - 0.012 15.6 5.1 0.026 14.5 5.1 1.6 1 0 0 1 1 1 0 Mucin-like Herpes_LMP1 PF05297.9 T300734_3 - 6.5 5.7 8.3 9.9 5.1 8.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Hexapep PF00132.22 T359857_1 - 0.021 14.4 0.0 2.9 7.6 0.0 3.7 4 0 0 4 4 4 0 Bacterial transferase hexapeptide (six repeats) Hexapep PF00132.22 T359857_2 - 0.019 14.6 0.1 62 3.4 0.0 4.9 4 1 0 4 4 4 0 Bacterial transferase hexapeptide (six repeats) Hexapep PF00132.22 T359857_3 - 0.053 13.1 0.0 16 5.3 0.0 3.4 3 0 0 3 3 3 0 Bacterial transferase hexapeptide (six repeats) LAMTOR5 PF16672.3 T138937_1 - 1.9e-07 30.8 10.1 10 6.0 0.1 9.0 1 1 13 14 14 14 5 Ragulator complex protein LAMTOR5 DUF3187 PF11383.6 T138937_1 - 0.0052 15.9 0.0 77 2.2 0.0 5.0 2 2 6 8 8 8 0 Protein of unknown function (DUF3187) DUF4633 PF15464.4 T138937_1 - 1.2 9.2 12.1 96 3.0 0.1 6.6 3 3 5 10 10 10 0 Domain of unknown function (DUF4633) RPN13_C PF16550.3 T138937_3 - 0.036 14.1 0.0 2.4e+02 1.8 0.0 5.0 1 1 6 9 9 9 0 UCH-binding domain YchF-GTPase_C PF06071.11 T138937_3 - 2.1 8.5 14.0 14 5.8 0.1 5.7 2 1 3 6 6 6 0 Protein of unknown function (DUF933) CDK5_activator PF03261.13 T138937_3 - 5.8 6.2 5.8 66 2.7 0.5 3.2 3 1 0 3 3 3 0 Cyclin-dependent kinase 5 activator protein DUF106 PF01956.14 T149684_1 - 0.018 14.6 7.8 0.027 14.1 7.8 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF106 SID-1_RNA_chan PF13965.4 T149684_1 - 0.22 9.8 0.6 0.28 9.5 0.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CDC45 PF02724.12 T149684_1 - 0.42 8.7 9.7 0.62 8.2 9.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.20 T149684_1 - 0.58 9.2 3.0 0.81 8.7 3.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RP-C_C PF11800.6 T149684_1 - 1.2 9.0 6.5 1.8 8.5 6.5 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region V_ATPase_I PF01496.17 T149684_1 - 1.5 6.5 9.5 2 6.1 9.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PA26 PF04636.11 T149684_1 - 2.2 7.0 9.6 3.1 6.5 9.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Med19 PF10278.7 T149684_1 - 5.2 6.8 32.9 9.2 6.0 32.9 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Sec62 PF03839.14 T149684_1 - 6.7 6.0 16.1 9.9 5.5 16.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 RR_TM4-6 PF06459.10 T149684_1 - 9.1 5.9 16.0 13 5.4 16.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2605 PF10792.7 T149684_2 - 0.14 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) SR-25 PF10500.7 T149684_2 - 1.8 8.0 24.1 3.7 7.0 24.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med19 PF10278.7 T149684_3 - 0.64 9.8 26.0 1 9.1 26.0 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Tim54 PF11711.6 T149684_3 - 4.3 5.9 13.0 6.2 5.4 13.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 dUTPase PF00692.17 T295830_2 - 3.8e-06 26.5 0.0 5.7e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 dUTPase rve PF00665.24 T038634_1 - 2.7e-05 24.2 0.0 4.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain LRR19-TM PF15176.4 T235992_3 - 8.4 6.3 11.2 24 4.8 11.2 1.7 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF4519 PF15012.4 T166067_3 - 0.071 13.1 0.1 0.071 13.1 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) COX3 PF00510.16 T107572_3 - 0.31 10.7 1.9 0.48 10.1 1.9 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase subunit III VCX_VCY PF15231.4 T381754_1 - 3.4e-06 27.6 0.4 4.6e-06 27.2 0.4 1.1 1 0 0 1 1 1 1 Variable charge X/Y family Exo_endo_phos_2 PF14529.4 T286672_1 - 0.00016 21.4 0.1 0.00031 20.4 0.1 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T286672_1 - 0.0055 16.8 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T286672_2 - 5.3e-116 387.3 8.9 7.2e-116 386.9 8.9 1.1 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T286672_3 - 1.1e-24 86.8 6.3 1.7e-24 86.2 6.3 1.2 1 0 0 1 1 1 1 L1 transposable element Med2 PF11214.6 T286672_3 - 0.01 15.9 0.3 0.02 14.9 0.3 1.4 1 0 0 1 1 1 0 Mediator complex subunit 2 DUF4613 PF15390.4 T286672_3 - 0.071 11.3 4.9 0.1 10.8 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Gag_p30 PF02093.14 T260074_1 - 9.4e-13 48.0 0.4 1.3e-12 47.6 0.4 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p30 PF02093.14 T260074_3 - 9.5e-24 84.0 0.1 1.3e-23 83.5 0.1 1.1 1 0 0 1 1 1 1 Gag P30 core shell protein 6PF2K PF01591.16 T260074_3 - 0.18 10.9 0.1 0.23 10.6 0.1 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Transposase_1 PF01359.16 T305788_3 - 2e-26 91.5 0.0 3.6e-26 90.7 0.0 1.4 1 0 0 1 1 1 1 Transposase (partial DDE domain) DDHD PF02862.15 T145649_1 - 0.23 11.4 9.3 0.31 11.0 9.3 1.1 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.10 T145649_1 - 0.88 9.2 28.5 1.2 8.8 28.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.15 T145649_1 - 1.7 7.2 19.2 2.4 6.7 19.2 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.11 T145649_1 - 2.3 6.8 24.5 3 6.4 24.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SpoIIP PF07454.9 T145649_1 - 3.7 6.8 14.9 6.5 6.0 14.9 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) BORG_CEP PF14957.4 T145649_1 - 4.5 8.3 8.2 7.4 7.6 8.2 1.4 1 0 0 1 1 1 0 Cdc42 effector DDHD PF02862.15 T145649_2 - 2.2 8.2 10.6 3.1 7.7 10.6 1.1 1 0 0 1 1 1 0 DDHD domain Zip PF02535.20 T145649_2 - 5 6.1 11.5 6.4 5.8 11.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MIP-T3 PF10243.7 T145649_3 - 0.017 13.7 43.0 0.024 13.2 43.0 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1510 PF07423.9 T145649_3 - 0.13 11.6 23.1 0.2 10.9 23.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF3807 PF12720.5 T145649_3 - 3.4 7.8 30.3 6.8 6.8 30.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) HERV-K_env_2 PF13804.4 T192686_2 - 1.1e-46 158.6 0.4 1.7e-46 157.9 0.4 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GP41 PF00517.15 T192686_2 - 2.9e-17 63.0 3.0 5.6e-17 62.1 3.0 1.3 1 0 0 1 1 1 1 Retroviral envelope protein IN_DBD_C PF00552.19 T192686_2 - 0.0011 18.1 0.1 0.0026 16.9 0.1 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain HERV-K_REC PF15695.3 T192686_2 - 0.027 14.4 0.3 0.053 13.5 0.3 1.4 1 0 0 1 1 1 0 Rec (regulator of expression encoded by corf) of HERV-K-113 DUF1028 PF06267.10 T258965_3 - 4.7 6.8 6.6 10 5.7 6.6 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF1028) BDV_P40 PF06407.9 T358159_2 - 2.9e-14 52.8 0.1 4.5e-14 52.2 0.1 1.2 1 0 0 1 1 1 1 Borna disease virus P40 protein BDV_P40 PF06407.9 T358159_3 - 1.7e-28 99.6 0.0 3e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 Borna disease virus P40 protein Transposase_22 PF02994.12 T377439_1 - 3.7e-122 407.6 22.1 5e-108 361.1 10.2 2.3 2 0 0 2 2 2 2 L1 transposable element RVT_1 PF00078.25 T377439_3 - 2.1e-43 148.3 1.2 2.1e-43 148.3 1.2 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3678 PF12435.6 T179750_3 - 0.046 12.8 0.5 0.21 10.7 0.5 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) DUF1725 PF08333.9 T184927_3 - 1.4e-06 27.7 0.3 2.8e-06 26.7 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Caerin_1 PF07440.10 T369379_2 - 0.21 11.6 1.1 0.53 10.3 1.1 1.6 1 0 0 1 1 1 0 Caerin 1 protein Lipocalin PF00061.21 T368850_1 - 0.048 13.7 0.0 0.5 10.4 0.0 2.1 2 0 0 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family Cyt-b5 PF00173.26 T058839_3 - 1.5e-12 47.3 0.0 2.4e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Transposase_22 PF02994.12 T165139_3 - 3.1e-07 29.5 0.7 4.9e-07 28.8 0.7 1.2 1 0 0 1 1 1 1 L1 transposable element DUF2981 PF11200.6 T165139_3 - 6.1 5.8 10.0 21 4.0 2.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2981) TSGP1 PF07771.9 T149369_3 - 1.5 8.8 5.6 4.4 7.3 5.6 1.7 1 0 0 1 1 1 0 Tick salivary peptide group 1 Lamprin PF06403.9 T221920_3 - 0.015 15.2 8.9 0.033 14.0 8.9 1.5 1 0 0 1 1 1 0 Lamprin Trypan_PARP PF05887.9 T175438_2 - 3.3 7.6 7.6 5.4 6.9 7.6 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PELOTA_1 PF15608.4 T165131_2 - 2.7 7.8 51.7 2.6 7.9 0.3 11.6 1 1 10 12 12 12 0 PELOTA RNA binding domain rve PF00665.24 T268416_1 - 9.8e-18 64.4 0.0 1.7e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain HERV-K_env_2 PF13804.4 T268416_1 - 1.6e-10 40.9 0.1 2.7e-10 40.1 0.1 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein Integrase_Zn PF02022.17 T268416_1 - 4.4e-10 39.2 0.6 1.1e-09 37.9 0.6 1.7 1 0 0 1 1 1 1 Integrase Zinc binding domain IN_DBD_C PF00552.19 T268416_1 - 3.8e-05 22.7 0.5 9.5e-05 21.5 0.5 1.7 1 0 0 1 1 1 1 Integrase DNA binding domain RVT_thumb PF06817.12 T268416_2 - 6.7e-30 102.5 0.1 1.4e-29 101.5 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RNase_H PF00075.22 T268416_2 - 1.5e-11 44.6 0.0 2.9e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 RNase H HERV-K_REC PF15695.3 T268416_2 - 0.0002 21.2 1.0 0.00035 20.4 1.0 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 RVP PF00077.18 T268416_3 - 1.3e-21 76.6 0.1 2.7e-21 75.6 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease dUTPase PF00692.17 T268416_3 - 6.8e-16 58.0 0.0 1.2e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 dUTPase G-patch PF01585.21 T268416_3 - 8.6e-09 35.1 0.4 1.5e-08 34.3 0.4 1.4 1 0 0 1 1 1 1 G-patch domain gag-asp_proteas PF13975.4 T268416_3 - 0.034 14.6 0.0 0.058 13.8 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease SelP_N PF04592.12 T184392_2 - 1.1 8.5 12.3 1.8 7.8 12.3 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PT PF04886.10 T178263_3 - 3.5 7.1 17.0 5.3 6.6 0.5 4.8 4 0 0 4 4 4 0 PT repeat HMG_box PF00505.17 T260458_2 - 5.3e-10 39.4 0.0 1.2e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 T260458_2 - 0.0033 17.9 0.0 0.0063 17.0 0.0 1.3 1 0 0 1 1 1 1 HMG-box domain RVT_1 PF00078.25 T267168_2 - 1.5e-27 96.4 2.0 2.2e-27 95.9 2.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T267168_2 - 5.5e-07 28.9 0.1 1.1e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF2161 PF09929.7 T295986_1 - 0.24 11.4 0.7 37 4.3 0.0 3.6 4 0 0 4 4 4 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) Serpin PF00079.18 T295986_2 - 1.6e-05 24.3 0.0 2.3e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-C3H1 PF10650.7 T160124_1 - 0.031 13.9 1.2 0.096 12.3 1.2 1.9 1 0 0 1 1 1 0 Putative zinc-finger domain zf-CCHC PF00098.21 T332060_3 - 2.5e-06 27.1 4.5 7.1e-06 25.7 4.5 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.4 T332060_3 - 0.098 12.2 1.8 0.098 12.2 0.2 1.9 2 0 0 2 2 2 0 Zinc knuckle Arylesterase PF01731.18 T381585_2 - 0.052 13.6 0.0 0.098 12.7 0.0 1.4 1 0 0 1 1 1 0 Arylesterase YjbE PF11106.6 T124974_1 - 0.081 13.0 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Exopolysaccharide production protein YjbE Colipase-like PF15083.4 T090348_3 - 1.4e-32 111.5 11.3 2.5e-32 110.7 11.3 1.3 1 0 0 1 1 1 1 Colipase-like DUF4391 PF14335.4 T270510_2 - 0.29 10.7 12.1 0.16 11.5 10.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4391) HR1 PF02185.14 T270510_2 - 8.9 6.4 13.3 0.38 10.8 1.2 2.7 3 0 0 3 3 3 0 Hr1 repeat Pentapeptide_4 PF13599.4 T358919_3 - 5e-13 48.8 5.4 6.5e-06 26.1 2.2 3.3 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) CCDC144C PF14915.4 T018797_1 - 1.2e-29 103.2 13.6 1.2e-29 103.2 13.6 3.2 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region BAR_3_WASP_bdg PF10456.7 T018797_1 - 8.9e-09 35.0 0.4 8.9e-09 35.0 0.4 2.2 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein Laminin_II PF06009.10 T018797_1 - 0.44 10.4 18.6 0.012 15.5 1.1 2.5 2 0 0 2 2 2 0 Laminin Domain II CCDC144C PF14915.4 T018797_2 - 3e-07 29.7 3.0 4.2e-07 29.3 3.0 1.2 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region CCDC144C PF14915.4 T018797_3 - 2.9e-29 102.0 16.4 2.9e-29 102.0 16.4 2.7 3 0 0 3 3 3 1 CCDC144C protein coiled-coil region DUF3496 PF12001.6 T018797_3 - 2.1e-16 60.1 5.4 2.1e-16 60.1 5.4 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3496) BAR_3_WASP_bdg PF10456.7 T018797_3 - 0.014 14.7 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 WASP-binding domain of Sorting nexin protein DUF1028 PF06267.10 T258996_1 - 5.6 6.6 6.6 10 5.7 6.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) cNMP_binding PF00027.27 T265030_2 - 0.00014 21.6 0.0 0.0002 21.2 0.0 1.1 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain AZUL PF16558.3 T138628_2 - 0.69 10.1 4.7 1.1 9.4 0.9 2.7 2 0 0 2 2 2 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A DUF1028 PF06267.10 T258984_2 - 4.8 6.8 6.6 9.4 5.8 6.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF1028) EF-hand_7 PF13499.4 T156313_1 - 5.9e-14 52.2 0.0 1.1e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 T156313_1 - 4.1e-11 41.5 0.1 8.1e-05 21.8 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 T156313_1 - 2.2e-07 30.4 0.1 6.9e-06 25.6 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.4 T156313_1 - 6.3e-07 28.5 0.1 0.025 14.0 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 T156313_1 - 7.3e-07 28.5 0.0 0.0011 18.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain zf-H2C2_2 PF13465.4 T364935_1 - 1.7e-92 299.9 112.7 2.1e-09 37.3 0.1 15.4 15 0 0 15 15 15 12 Zinc-finger double domain zf-C2H2 PF00096.24 T364935_1 - 2.9e-66 216.3 114.7 1.2e-07 31.7 0.7 14.1 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T364935_1 - 8.8e-37 122.4 110.2 0.0015 19.0 0.5 14.2 14 0 0 14 14 13 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T364935_1 - 7e-26 89.5 100.5 0.0019 18.0 0.7 14.1 14 0 0 14 14 14 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T364935_1 - 6e-11 42.2 62.1 0.02 15.1 0.4 12.1 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T364935_1 - 1.8e-08 34.2 77.0 0.0082 16.1 3.5 9.5 2 2 9 12 12 12 8 Zinc ribbon domain zf-C2H2_11 PF16622.3 T364935_1 - 1.5e-06 27.7 76.2 0.028 14.1 0.2 12.7 13 0 0 13 13 13 6 zinc-finger C2H2-type zf-met PF12874.5 T364935_1 - 0.00013 22.1 93.3 0.0074 16.5 0.8 12.3 12 0 0 12 12 12 5 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 T364935_1 - 0.00056 20.5 61.6 0.024 15.3 1.3 7.1 2 2 5 7 7 7 5 zinc-ribbon family XPA_N PF01286.16 T364935_1 - 0.0025 17.7 57.8 2.8 7.9 0.1 12.8 13 0 0 13 13 13 3 XPA protein N-terminal C1_4 PF07975.10 T364935_1 - 0.73 10.0 74.1 1.4 9.1 3.0 9.1 1 1 8 11 11 11 0 TFIIH C1-like domain SlyX PF04102.10 T288555_2 - 0.061 13.8 20.8 0.2 12.2 1.9 3.5 2 1 1 3 3 3 0 SlyX PspA_IM30 PF04012.10 T288555_2 - 1.6 8.2 26.1 0.045 13.2 1.6 3.1 2 1 1 3 3 3 0 PspA/IM30 family Fib_alpha PF08702.8 T288555_2 - 7.6 6.6 17.6 4.8 7.2 8.1 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Transposase_22 PF02994.12 T172290_1 - 1.1e-25 90.1 3.2 1.6e-25 89.6 0.9 1.9 2 0 0 2 2 2 1 L1 transposable element zf-CCHC PF00098.21 T172290_1 - 6.3e-05 22.7 3.2 6.3e-05 22.7 3.2 2.9 2 0 0 2 2 2 1 Zinc knuckle Gag_p30 PF02093.14 T172290_2 - 0.012 15.0 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein Rsm1 PF08600.8 T352147_1 - 0.00057 19.9 57.3 0.62 10.1 0.1 16.1 12 4 5 17 17 17 4 Rsm1-like B3R PF17057.3 T352147_1 - 0.019 15.1 0.3 3.3e+02 1.4 0.0 6.6 9 1 1 10 10 10 0 Poxviridae B3 protein ATPase_gene1 PF09527.8 T352147_2 - 0.015 15.3 12.2 3e+02 1.6 0.0 10.8 14 0 0 14 14 14 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Rsm1 PF08600.8 T352147_2 - 0.54 10.3 56.9 0.26 11.4 0.1 15.6 15 4 1 16 16 16 0 Rsm1-like B3R PF17057.3 T352147_3 - 0.043 13.9 0.8 1.3e+02 2.7 0.0 6.2 10 0 0 10 10 10 0 Poxviridae B3 protein EF1G PF00647.17 T352147_3 - 0.15 12.0 0.0 61 3.6 0.0 3.7 3 0 0 3 3 3 0 Elongation factor 1 gamma, conserved domain Rsm1 PF08600.8 T352147_3 - 1.2 9.2 58.2 0.32 11.0 0.6 15.2 9 4 7 16 16 16 0 Rsm1-like rve PF00665.24 T200710_2 - 0.003 17.6 0.0 0.013 15.6 0.0 2.0 1 1 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T200710_3 - 1.6e-13 50.9 0.0 2.6e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 RNase H DUF4705 PF15788.3 T323210_1 - 8.3e-97 317.1 444.4 3.1e-17 62.4 8.0 40.8 23 12 17 41 41 41 32 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323210_2 - 9.2e-64 211.3 457.7 1.1e-15 57.4 9.2 39.4 25 11 11 36 36 36 27 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323210_3 - 4.7e-19 68.2 62.0 1.5e-11 44.2 11.0 39.3 19 11 13 34 34 34 16 Domain of unknown function (DUF4705) RVT_1 PF00078.25 T260355_1 - 0.013 14.9 0.1 0.018 14.4 0.1 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.4 T260355_2 - 8.8e-08 31.9 0.3 1.8e-07 30.9 0.3 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 T260355_2 - 0.028 14.6 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Transposase_22 PF02994.12 T260355_3 - 2.8e-129 431.0 27.3 2.8e-128 427.7 27.3 2.0 1 1 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T260355_3 - 0.079 13.1 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.25 T239486_3 - 8.2e-52 175.8 1.8 1.6e-51 174.9 1.8 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.4 T239486_3 - 0.004 16.6 0.3 0.0085 15.6 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4417) YlbE PF14003.4 T239486_3 - 0.5 10.7 0.0 0.5 10.7 0.0 3.2 3 0 0 3 3 3 0 YlbE-like protein Herpes_BLLF1 PF05109.11 T330805_1 - 0.017 13.0 147.5 0.058 11.3 27.3 4.4 2 1 2 4 4 4 0 Herpes virus major outer envelope glycoprotein (BLLF1) HERV-K_env_2 PF13804.4 T085586_1 - 0.00058 19.5 0.1 0.00095 18.8 0.1 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein rve PF00665.24 T085586_2 - 1e-21 77.2 0.0 1.7e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain IN_DBD_C PF00552.19 T085586_2 - 1.4e-06 27.4 1.0 2.5e-06 26.6 1.0 1.4 1 0 0 1 1 1 1 Integrase DNA binding domain Integrase_Zn PF02022.17 T085586_2 - 5.2e-06 26.2 0.4 1.1e-05 25.1 0.4 1.6 1 0 0 1 1 1 1 Integrase Zinc binding domain DDE_Tnp_IS240 PF13610.4 T085586_2 - 0.05 13.7 0.0 0.077 13.1 0.0 1.2 1 0 0 1 1 1 0 DDE domain HERV-K_REC PF15695.3 T085586_3 - 0.00072 19.4 0.6 0.0013 18.6 0.6 1.3 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 MIP-T3 PF10243.7 T281978_1 - 0.42 9.2 87.6 0.61 8.6 87.6 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 GP41 PF00517.15 T128228_2 - 2.7e-15 56.6 2.4 5.2e-15 55.7 2.4 1.4 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_REC PF15695.3 T128228_2 - 3.7e-07 30.0 2.8 7.3e-07 29.0 2.8 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Fusion_gly PF00523.16 T128228_2 - 0.16 10.0 2.5 0.12 10.4 0.2 1.7 2 0 0 2 2 2 0 Fusion glycoprotein F0 HERV-K_env_2 PF13804.4 T128228_3 - 3.4e-45 153.7 0.4 5.7e-45 153.0 0.4 1.2 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein RVT_1 PF00078.25 T374602_1 - 2e-15 56.8 0.0 3.1e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.24 T374602_1 - 2.4e-11 43.7 0.0 4.2e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Gag_MA PF01140.17 T374602_1 - 4.5e-09 35.9 0.1 8.4e-09 35.1 0.1 1.4 1 0 0 1 1 1 1 Matrix protein (MA), p15 zf-H2C2 PF09337.8 T374602_1 - 1.7e-06 28.1 0.2 4.3e-06 26.8 0.2 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RNase_H PF00075.22 T374602_1 - 0.00011 22.3 0.0 0.00018 21.6 0.0 1.2 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T374602_3 - 3.6e-52 176.8 0.9 5.1e-52 176.3 0.9 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T374602_3 - 2.2e-13 50.2 0.0 3.8e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.4 T374602_3 - 0.042 14.4 0.0 0.077 13.5 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T374602_3 - 0.05 14.0 0.0 0.092 13.2 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Methyltransf_6 PF03737.13 T374602_3 - 0.16 12.0 0.0 0.27 11.3 0.0 1.2 1 0 0 1 1 1 0 Demethylmenaquinone methyltransferase Peptidase_S49_N PF08496.8 T188443_3 - 6.1 6.8 5.6 11 6.0 5.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MIP-T3 PF10243.7 T364283_1 - 0.3 9.6 11.8 0.41 9.2 11.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Auts2 PF15336.4 T364283_1 - 9.4 6.2 18.9 11 5.9 17.9 1.7 1 1 0 1 1 1 0 Autism susceptibility gene 2 protein DUF3915 PF13054.4 T364283_2 - 0.78 9.6 13.6 1.5 8.7 13.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) MIP-T3 PF10243.7 T364283_3 - 0.19 10.3 6.6 0.27 9.8 6.6 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF982 PF06169.10 T079587_3 - 5.2 7.0 6.1 11 6.0 6.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF982) TLV_coat PF00429.17 T370857_2 - 9.7e-07 27.7 0.4 4.3e-06 25.6 0.4 1.8 1 1 0 1 1 1 1 ENV polyprotein (coat polyprotein) DUF4444 PF14563.4 T089882_2 - 0.66 9.5 3.5 30 4.3 0.2 4.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4444) MgtE_N PF03448.15 T089882_3 - 1.3e-10 41.7 0.0 0.094 13.2 0.0 3.6 2 2 2 4 4 4 4 MgtE intracellular N domain DUF4444 PF14563.4 T089882_3 - 0.6 9.7 49.0 7.2 6.2 0.1 14.7 7 3 10 19 19 19 0 Domain of unknown function (DUF4444) MRFAP1 PF15155.4 T260526_3 - 2.1e-56 189.4 14.0 3.8e-56 188.6 14.0 1.4 1 0 0 1 1 1 1 MORF4 family-associated protein1 Mucin-like PF16058.3 T294686_3 - 6.5e-05 22.8 2.3 0.32 11.0 0.0 4.1 3 1 1 4 4 4 2 Mucin-like GAIN PF16489.3 T229036_1 - 7.8e-10 38.4 0.0 1.1e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.19 T229036_2 - 0.00079 19.9 0.2 0.013 16.0 0.1 2.8 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif BmKX PF09132.8 T137780_1 - 0.019 14.8 4.6 1.3e+02 2.5 0.1 5.7 6 0 0 6 6 6 0 BmKX BmKX PF09132.8 T137780_2 - 0.064 13.1 8.7 1.2e+02 2.7 0.0 6.2 6 0 0 6 6 6 0 BmKX DUF3903 PF13043.4 T137780_2 - 0.8 9.5 4.9 1.8e+02 2.0 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF3903) BmKX PF09132.8 T137780_3 - 0.036 13.9 0.3 1.2e+02 2.7 0.0 4.5 4 0 0 4 4 4 0 BmKX HERV-K_env_2 PF13804.4 T115942_1 - 4e-50 169.7 0.5 6.4e-50 169.1 0.5 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GP41 PF00517.15 T115942_1 - 5.2e-09 36.1 0.4 9.5e-09 35.2 0.4 1.3 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_REC PF15695.3 T115942_2 - 7.6e-10 38.6 1.1 1.4e-09 37.7 1.1 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Transposase_22 PF02994.12 T103721_2 - 2e-142 474.2 20.5 2.8e-142 473.8 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103721_2 - 0.029 14.5 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103721_2 - 0.058 13.0 10.5 0.11 12.2 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103721_2 - 0.059 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103721_2 - 0.34 11.4 5.0 0.68 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103721_2 - 0.41 9.8 12.3 0.73 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103721_2 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103721_2 - 2.7 8.1 7.4 4.8 7.4 6.6 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein HTH_24 PF13412.4 T268992_1 - 0.065 12.7 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Transposase_1 PF01359.16 T268992_2 - 6.9e-19 67.4 0.8 1e-18 66.8 0.0 1.8 2 0 0 2 2 2 1 Transposase (partial DDE domain) DDE_3 PF13358.4 T268992_2 - 0.019 14.6 0.1 0.037 13.6 0.1 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF4417 PF14386.4 T268992_3 - 0.011 15.2 0.1 0.022 14.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) zf-CCHC_5 PF14787.4 T167929_1 - 3.5e-16 58.5 1.3 3.5e-16 58.5 1.3 2.0 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger Gag_p24 PF00607.18 T167929_1 - 0.00018 21.3 0.0 0.00029 20.6 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) HERV-K_REC PF15695.3 T167929_1 - 0.017 15.0 0.1 0.034 14.1 0.1 1.4 1 0 0 1 1 1 0 Rec (regulator of expression encoded by corf) of HERV-K-113 Gag_p24 PF00607.18 T167929_2 - 2.7e-29 102.4 0.0 2.8e-24 86.0 0.0 2.2 2 0 0 2 2 2 2 gag gene protein p24 (core nucleocapsid protein) Gag_p10 PF02337.15 T167929_2 - 3.2e-06 26.8 0.1 6.6e-06 25.8 0.1 1.5 1 0 0 1 1 1 1 Retroviral GAG p10 protein Gag_p10 PF02337.15 T167929_3 - 5.9e-05 22.7 0.0 0.0001 21.9 0.0 1.3 1 0 0 1 1 1 1 Retroviral GAG p10 protein Transposase_22 PF02994.12 T081230_2 - 5.1e-54 183.4 2.6 5.1e-54 183.4 2.6 1.8 2 0 0 2 2 2 1 L1 transposable element Exo_endo_phos_2 PF14529.4 T081230_2 - 0.00033 20.4 0.0 0.0006 19.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF1725 PF08333.9 T081230_3 - 9.5e-06 25.0 0.1 2e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Transposase_1 PF01359.16 T351121_1 - 0.025 14.3 0.1 0.076 12.8 0.1 1.7 1 0 0 1 1 1 0 Transposase (partial DDE domain) Transposase_1 PF01359.16 T351121_2 - 6e-21 74.0 7.5 1.5e-20 72.7 4.6 2.5 2 0 0 2 2 2 1 Transposase (partial DDE domain) DDE_3 PF13358.4 T351121_2 - 0.0027 17.3 0.3 0.0048 16.5 0.3 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BEN PF10523.7 T351121_2 - 0.055 13.6 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 BEN domain RNase_H PF00075.22 T168761_1 - 3.7e-10 40.0 0.0 6.4e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p10 PF02337.15 T168761_1 - 3.1e-09 36.4 0.2 5.7e-09 35.6 0.2 1.4 1 0 0 1 1 1 1 Retroviral GAG p10 protein IN_DBD_C PF00552.19 T168761_1 - 0.004 16.3 0.5 0.01 15.0 0.5 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain Gag_p24 PF00607.18 T168761_2 - 2.8e-35 121.9 0.0 4.3e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) GP41 PF00517.15 T168761_2 - 1.2e-08 35.0 4.8 2e-08 34.2 4.8 1.3 1 0 0 1 1 1 1 Retroviral envelope protein HERV-K_REC PF15695.3 T168761_2 - 0.00049 20.0 0.7 0.0012 18.8 0.7 1.6 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 Gag_p30 PF02093.14 T168761_2 - 0.025 14.0 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein G-patch PF01585.21 T168761_2 - 0.051 13.4 0.3 0.091 12.6 0.3 1.4 1 0 0 1 1 1 0 G-patch domain RVT_thumb PF06817.12 T168761_3 - 2.6e-18 65.3 0.1 5.6e-18 64.3 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RVT_1 PF00078.25 T168761_3 - 1.3e-08 34.5 0.0 2.1e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_Zn PF02022.17 T168761_3 - 0.00039 20.2 0.4 0.0012 18.6 0.4 1.9 1 0 0 1 1 1 1 Integrase Zinc binding domain rve PF00665.24 T168761_3 - 0.0055 16.8 0.1 0.068 13.2 0.1 2.2 2 0 0 2 2 2 1 Integrase core domain Transposase_22 PF02994.12 T203338_2 - 4e-104 348.2 15.3 8e-104 347.3 15.3 1.4 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T203338_2 - 1.7e-33 115.9 0.2 3.2e-33 115.0 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1664 PF07889.10 T203338_2 - 0.018 14.9 4.1 0.61 9.9 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sec34 PF04136.13 T203338_2 - 0.027 14.2 2.0 0.059 13.1 2.0 1.5 1 0 0 1 1 1 0 Sec34-like family Spectrin PF00435.19 T203338_2 - 0.049 14.0 5.6 0.12 12.7 5.6 1.6 1 0 0 1 1 1 0 Spectrin repeat zf-C4H2 PF10146.7 T203338_2 - 0.078 13.1 13.1 0.024 14.8 8.5 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein KLRAQ PF10205.7 T203338_2 - 0.17 12.0 4.4 0.54 10.4 4.4 1.9 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Prominin PF05478.9 T203338_2 - 0.22 9.3 2.5 0.39 8.5 2.5 1.3 1 0 0 1 1 1 0 Prominin Med2 PF11214.6 T203338_2 - 0.55 10.3 6.3 0.21 11.6 2.4 2.4 2 1 0 2 2 2 0 Mediator complex subunit 2 Syntaxin-6_N PF09177.9 T203338_2 - 0.67 10.4 9.6 0.1 13.0 5.2 1.9 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Coilin_N PF15862.3 T068778_3 - 0.00082 19.0 9.2 0.0013 18.4 9.2 1.2 1 0 0 1 1 1 1 Coilin N-terminus Eapp_C PF10238.7 T068778_3 - 0.066 13.2 3.6 0.14 12.1 3.6 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF2011 PF09428.8 T068778_3 - 0.1 12.5 27.8 0.19 11.6 27.8 1.3 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) DDHD PF02862.15 T068778_3 - 0.15 12.0 1.3 0.23 11.4 1.3 1.2 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.10 T068778_3 - 0.23 11.1 15.3 0.35 10.5 15.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.6 T068778_3 - 0.82 8.3 20.0 1.1 7.9 20.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Rrn6 PF10214.7 T068778_3 - 2 6.6 9.8 3 6.0 9.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1510 PF07423.9 T068778_3 - 3 7.1 16.5 5.1 6.4 16.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SpoIIP PF07454.9 T068778_3 - 3.2 7.0 8.0 5.3 6.3 8.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CCDC71L PF15374.4 T068778_3 - 3.4 6.7 12.5 5.2 6.1 12.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L FLO_LFY PF01698.14 T068778_3 - 5.9 5.9 10.0 8.9 5.3 10.0 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Tim54 PF11711.6 T068778_3 - 6 5.4 14.1 8.7 4.9 14.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AAA_11 PF13086.4 T068778_3 - 6.1 6.4 10.7 9.2 5.8 10.7 1.1 1 0 0 1 1 1 0 AAA domain Sec62 PF03839.14 T068778_3 - 7.7 5.8 17.8 13 5.1 17.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2058 PF09831.7 T068778_3 - 9.8 6.1 19.0 21 5.0 17.3 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) Comm PF15957.3 T120032_3 - 1 9.6 3.2 2.7 8.2 3.2 1.6 1 0 0 1 1 1 0 Commissureless Transposase_22 PF02994.12 T377476_2 - 6.9e-159 528.4 22.3 9.5e-159 528.0 22.3 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T377476_2 - 1.4e-09 38.0 0.0 2.3e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T377476_2 - 9.4e-09 35.0 1.1 2e-08 34.0 1.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase GAS PF13851.4 T377476_2 - 0.0041 16.4 7.8 0.0075 15.5 7.8 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.20 T377476_2 - 0.051 13.7 7.7 0.11 12.6 7.7 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.9 T377476_2 - 0.11 12.5 10.0 0.27 11.3 10.0 1.6 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF812 PF05667.9 T377476_2 - 0.12 11.1 14.3 0.18 10.5 14.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) KLRAQ PF10205.7 T377476_2 - 0.25 11.5 8.6 0.34 11.0 7.1 2.0 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Syntaxin-6_N PF09177.9 T377476_2 - 0.28 11.6 9.7 0.2 12.1 6.4 2.2 2 0 0 2 2 2 0 Syntaxin 6, N-terminal TPR_MLP1_2 PF07926.10 T377476_2 - 0.33 10.9 9.0 0.63 10.0 9.0 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Mnd1 PF03962.13 T377476_2 - 0.36 10.5 9.5 0.65 9.7 9.5 1.3 1 0 0 1 1 1 0 Mnd1 family APG6 PF04111.10 T377476_2 - 0.37 10.0 12.5 0.6 9.3 12.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 T377476_2 - 0.67 9.6 11.7 1.1 8.8 11.7 1.3 1 0 0 1 1 1 0 IncA protein DUF724 PF05266.12 T377476_2 - 1.1 9.0 9.5 2 8.1 9.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) CENP-F_leu_zip PF10473.7 T377476_2 - 2 8.3 14.7 3.9 7.4 14.7 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TBPIP PF07106.11 T377476_2 - 3 7.5 12.6 11 5.6 12.6 1.9 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Collagen PF01391.16 T212059_2 - 0.065 12.9 16.3 0.2 11.3 16.3 1.8 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) RVT_1 PF00078.25 T307839_3 - 2.7e-11 43.3 0.2 4e-11 42.7 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Orn_DAP_Arg_deC PF00278.20 T007019_1 - 7.2e-11 42.0 0.0 1.2e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Orn_Arg_deC_N PF02784.14 T007019_2 - 5.2e-05 22.7 0.0 7.4e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain DUF1736 PF08409.9 T337113_1 - 0.013 15.4 0.1 31 4.5 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1736) Tox-HNH-EHHH PF15657.4 T337113_3 - 0.61 10.3 8.4 18 5.6 0.2 3.6 3 0 0 3 3 3 0 HNH/Endo VII superfamily nuclease toxins HHV-5_US34A PF17087.3 T337113_3 - 4.5 7.4 11.3 16 5.6 0.4 3.4 3 0 0 3 3 3 0 Herpesvirus US34A protein family Homeobox PF00046.27 T379415_1 - 0.022 14.4 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Homeobox domain DUF3915 PF13054.4 T121016_1 - 0.15 11.9 5.6 0.2 11.5 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 T121016_1 - 0.27 11.7 22.3 0.43 11.0 22.3 1.3 1 0 0 1 1 1 0 FAM27 D and E protein family Mso1_Sec1_bdg PF14475.4 T121016_1 - 4 7.0 13.6 2.2 7.8 3.1 2.4 1 1 1 2 2 2 0 Sec1-binding region of Mso1 FAM27 PF15832.3 T121016_2 - 0.02 15.3 27.6 0.031 14.7 27.6 1.3 1 0 0 1 1 1 0 FAM27 D and E protein family Zip PF02535.20 T121016_2 - 0.3 10.1 0.8 0.26 10.3 0.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.15 T121016_2 - 1.4 7.4 3.9 1.7 7.1 3.9 1.1 1 0 0 1 1 1 0 Presenilin DUF1777 PF08648.10 T121016_3 - 0.00056 20.1 3.1 0.00068 19.8 3.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) DUF3915 PF13054.4 T121016_3 - 0.11 12.3 6.1 0.19 11.6 6.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Auts2 PF15336.4 T121016_3 - 0.37 10.8 6.9 0.56 10.2 6.9 1.2 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein PRP38_assoc PF12871.5 T121016_3 - 0.37 11.2 19.4 0.6 10.6 19.4 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF4705 PF15788.3 T323215_1 - 7.3e-69 227.7 402.5 1.2e-08 34.8 7.0 38.8 17 9 17 35 35 35 28 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323215_2 - 7.3e-62 205.3 406.4 1.5e-09 37.8 16.2 36.1 22 9 8 30 30 30 23 Domain of unknown function (DUF4705) DUF4705 PF15788.3 T323215_3 - 1.1e-50 169.5 402.0 2.7e-17 62.6 8.0 36.1 20 11 13 34 34 34 23 Domain of unknown function (DUF4705) Eapp_C PF10238.7 T327770_1 - 0.004 17.1 2.2 0.006 16.5 2.2 1.3 1 0 0 1 1 1 1 E2F-associated phosphoprotein SR-25 PF10500.7 T327770_1 - 0.0051 16.3 27.5 0.009 15.5 27.5 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4820 PF16091.3 T327770_1 - 0.061 12.6 6.1 0.09 12.0 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RNA_pol_Rpc4 PF05132.12 T327770_1 - 0.77 10.1 11.7 1.1 9.6 11.7 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 NPR3 PF03666.11 T327770_1 - 4 6.0 19.8 5.5 5.5 19.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Spore_coat_CotO PF14153.4 T327770_3 - 0.00047 20.0 8.6 0.00065 19.6 8.6 1.1 1 0 0 1 1 1 1 Spore coat protein CotO CPSF100_C PF13299.4 T327770_3 - 0.0012 18.9 3.1 0.0017 18.4 3.1 1.1 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal SpoIIP PF07454.9 T327770_3 - 0.013 14.9 4.9 0.018 14.4 4.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.12 T327770_3 - 0.023 12.9 16.2 0.03 12.5 16.2 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.10 T327770_3 - 0.023 14.0 20.7 0.033 13.5 20.7 1.1 1 0 0 1 1 1 0 SDA1 RNA_pol_Rpc4 PF05132.12 T327770_3 - 0.037 14.4 3.5 0.056 13.8 3.5 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.15 T327770_3 - 0.057 12.0 4.7 0.082 11.5 4.7 1.1 1 0 0 1 1 1 0 Presenilin DDHD PF02862.15 T327770_3 - 0.089 12.8 0.5 0.13 12.3 0.5 1.2 1 0 0 1 1 1 0 DDHD domain TCP PF03634.11 T327770_3 - 0.095 13.1 8.2 0.15 12.5 8.2 1.2 1 0 0 1 1 1 0 TCP family transcription factor DUF913 PF06025.10 T327770_3 - 0.096 11.5 2.8 0.13 11.1 2.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RAB3GAP2_C PF14656.4 T327770_3 - 0.17 9.9 4.6 0.23 9.5 4.6 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus TRAP_alpha PF03896.14 T327770_3 - 1 8.4 12.0 1.5 7.9 12.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BUD22 PF09073.8 T327770_3 - 1.4 8.0 19.9 1.9 7.6 19.9 1.1 1 0 0 1 1 1 0 BUD22 EIIBC-GUT_N PF03612.12 T327770_3 - 3.8 7.1 5.6 5.6 6.5 5.6 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3391 PF11871.6 T327770_3 - 4.2 7.8 12.0 6.1 7.3 12.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DUF4637 PF15470.4 T327770_3 - 4.9 6.8 26.0 8.8 6.0 26.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Transposase_1 PF01359.16 T013932_1 - 2.9e-27 94.2 0.2 6.4e-27 93.1 0.2 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) DDE_1 PF03184.17 T013932_1 - 2e-06 27.4 0.2 3.1e-06 26.8 0.2 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 T013932_2 - 1.4e-06 28.1 0.1 3.1e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.17 T013932_2 - 0.00096 18.6 0.1 0.002 17.6 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease Eapp_C PF10238.7 T068785_3 - 0.081 12.9 3.4 0.17 11.9 3.4 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF2011 PF09428.8 T068785_3 - 0.094 12.6 27.4 0.18 11.7 27.4 1.3 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) Coilin_N PF15862.3 T068785_3 - 0.11 12.2 15.5 0.17 11.5 15.5 1.2 1 0 0 1 1 1 0 Coilin N-terminus RR_TM4-6 PF06459.10 T068785_3 - 0.28 10.8 15.3 0.49 10.1 15.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.15 T068785_3 - 0.29 11.1 1.7 0.56 10.2 1.7 1.3 1 0 0 1 1 1 0 DDHD domain NARP1 PF12569.6 T068785_3 - 1.1 7.9 20.0 1.6 7.4 20.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Rrn6 PF10214.7 T068785_3 - 2.8 6.1 9.8 4.2 5.5 9.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor FLO_LFY PF01698.14 T068785_3 - 3.2 6.7 8.7 4.9 6.1 8.7 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein CCDC71L PF15374.4 T068785_3 - 3.6 6.6 12.2 5.4 6.0 12.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L DUF1510 PF07423.9 T068785_3 - 4.3 6.6 16.5 6.9 5.9 16.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SpoIIP PF07454.9 T068785_3 - 4.5 6.5 8.0 7.2 5.8 8.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.6 T068785_3 - 8.2 5.0 14.1 12 4.4 14.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AAA_11 PF13086.4 T068785_3 - 8.2 5.9 10.7 13 5.3 10.7 1.2 1 0 0 1 1 1 0 AAA domain EloA-BP1 PF15870.3 T356803_3 - 3.9e-10 40.2 0.1 6.3e-10 39.5 0.1 1.2 1 0 0 1 1 1 1 ElonginA binding-protein 1 Ank_2 PF12796.5 T131338_2 - 3.4e-05 24.2 0.4 5.4e-05 23.6 0.4 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 T131338_2 - 7.1e-05 23.1 1.0 0.00012 22.4 1.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 T131338_2 - 8e-05 22.6 1.8 0.018 15.4 0.2 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 T131338_2 - 0.0012 19.1 0.2 0.0026 18.0 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.28 T131338_2 - 0.0039 17.5 3.1 0.042 14.2 0.5 2.5 2 0 0 2 2 2 1 Ankyrin repeat YesK PF14150.4 T131338_3 - 0.058 13.4 0.4 0.11 12.6 0.4 1.4 1 0 0 1 1 1 0 YesK-like protein DUF4632 PF15451.4 T141181_2 - 2.8e-43 145.7 2.8 5.7e-43 144.7 2.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4632) zf-RING_UBOX PF13445.4 T141181_2 - 2.6e-07 30.4 1.1 7.5e-07 28.9 1.1 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 T141181_2 - 7.7e-06 25.6 3.3 7.7e-06 25.6 3.3 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 T141181_2 - 0.0015 18.6 4.0 0.0015 18.6 4.0 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.23 T141181_2 - 0.0015 18.2 2.1 0.0057 16.4 2.1 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Peptidase_S49_N PF08496.8 T188427_3 - 2.8 7.9 4.6 4.8 7.1 4.6 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PRP38_assoc PF12871.5 T132850_3 - 2.5 8.6 16.4 4.7 7.7 16.4 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Lamprin PF06403.9 T260632_1 - 0.83 9.5 7.1 1.8 8.4 7.1 1.5 1 0 0 1 1 1 0 Lamprin Lamprin PF06403.9 T260632_2 - 3.3 7.5 5.9 8 6.3 5.9 1.5 1 0 0 1 1 1 0 Lamprin HERV-K_env_2 PF13804.4 T202683_1 - 4.6e-37 127.2 0.2 7.2e-37 126.6 0.2 1.3 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein GP41 PF00517.15 T202683_3 - 4.8e-10 39.5 0.3 8.2e-10 38.7 0.3 1.3 1 0 0 1 1 1 1 Retroviral envelope protein Presenilin PF01080.15 T081044_1 - 0.72 8.4 26.8 1 7.9 26.8 1.1 1 0 0 1 1 1 0 Presenilin Presenilin PF01080.15 T081044_2 - 8.8 4.8 29.6 13 4.3 29.6 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.12 T081044_3 - 0.034 12.3 29.6 0.06 11.5 29.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.14 T081044_3 - 0.73 9.7 10.5 0.98 9.3 10.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.4 T081044_3 - 1.7 7.8 14.8 2.2 7.4 14.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ig_3 PF13927.4 T022826_1 - 0.011 16.2 0.1 5.9 7.4 0.1 2.5 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.14 T022826_1 - 0.071 13.1 0.0 0.42 10.6 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin I-set domain V-set PF07686.15 T022826_1 - 0.096 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin V-set domain Arylesterase PF01731.18 T381512_1 - 0.062 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Arylesterase RVT_1 PF00078.25 T292096_1 - 5.4e-43 146.9 2.3 8.2e-43 146.4 2.3 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Wbp11 PF09429.8 T094005_3 - 0.091 13.0 8.7 0.19 12.0 8.7 1.4 1 0 0 1 1 1 0 WW domain binding protein 11 GFO_IDH_MocA_C PF02894.15 T001698_3 - 0.19 11.6 0.0 0.49 10.3 0.0 1.6 2 0 0 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain Transposase_22 PF02994.12 T273751_1 - 1.3e-27 96.5 0.1 2.1e-27 95.8 0.1 1.2 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T273751_2 - 5.9e-67 226.0 20.7 3.1e-64 217.0 20.7 2.3 1 1 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T273751_2 - 1.9e-37 128.8 2.9 3e-37 128.2 2.9 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T273751_3 - 3.4e-07 29.6 0.1 6.2e-07 28.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DuoxA PF10204.7 T338865_2 - 0.074 11.9 7.8 0.32 9.8 7.7 1.9 2 0 0 2 2 2 0 Dual oxidase maturation factor Glycophorin_A PF01102.16 T338865_2 - 0.23 11.6 3.7 0.64 10.1 3.7 1.7 1 0 0 1 1 1 0 Glycophorin A DUF4191 PF13829.4 T338865_2 - 3.5 6.8 5.4 5.3 6.2 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) NPR2 PF06218.9 T212036_2 - 0.024 13.4 0.1 0.032 12.9 0.1 1.1 1 0 0 1 1 1 0 Nitrogen permease regulator 2 RVT_1 PF00078.25 T175026_2 - 3.4e-19 69.1 0.0 5.3e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gag_p30 PF02093.14 T175026_2 - 1.8e-10 40.6 0.1 3.1e-10 39.8 0.1 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVP PF00077.18 T175026_2 - 0.012 15.8 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.4 T175026_2 - 0.035 14.6 0.0 0.077 13.6 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T175026_2 - 0.046 14.1 0.0 0.084 13.3 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Gag_p30 PF02093.14 T175026_3 - 0.0038 16.6 0.0 0.0065 15.9 0.0 1.4 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_MA PF01140.17 T175026_3 - 0.041 13.4 0.1 0.076 12.6 0.1 1.4 1 0 0 1 1 1 0 Matrix protein (MA), p15 IN_DBD_C PF00552.19 T126057_2 - 3.3e-07 29.4 0.6 6.1e-07 28.5 0.6 1.5 1 0 0 1 1 1 1 Integrase DNA binding domain HERV-K_REC PF15695.3 T126057_3 - 0.00014 21.8 0.4 0.00027 20.8 0.4 1.4 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 LBP_BPI_CETP PF01273.23 T126057_3 - 2 7.9 5.1 15 5.0 0.1 2.7 2 0 0 2 2 2 0 LBP / BPI / CETP family, N-terminal domain PHO4 PF01384.18 T049497_3 - 0.011 14.7 0.0 0.011 14.7 0.0 2.0 2 0 0 2 2 2 0 Phosphate transporter family rve PF00665.24 T230577_1 - 5.8e-25 87.7 0.0 1.4e-24 86.4 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain Integrase_Zn PF02022.17 T230577_1 - 5.3e-15 54.9 2.7 1.5e-14 53.5 2.7 1.9 1 0 0 1 1 1 1 Integrase Zinc binding domain RNase_H PF00075.22 T230577_1 - 2.1e-08 34.3 0.0 4.1e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 RNase H GP41 PF00517.15 T230577_1 - 9.9e-06 25.4 0.1 1.8e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 Retroviral envelope protein DDE_Tnp_IS240 PF13610.4 T230577_1 - 0.022 14.8 0.0 0.035 14.2 0.0 1.2 1 0 0 1 1 1 0 DDE domain RVT_thumb PF06817.12 T230577_2 - 6.5e-08 32.1 0.4 1.2e-07 31.2 0.4 1.4 1 0 0 1 1 1 1 Reverse transcriptase thumb domain Borrelia_orfX PF04160.10 T230577_2 - 0.011 15.7 0.4 0.019 14.8 0.4 1.3 1 0 0 1 1 1 0 Orf-X protein HERV-K_env_2 PF13804.4 T230577_3 - 4.3e-65 218.4 2.8 8.3e-65 217.5 2.8 1.4 1 0 0 1 1 1 1 Retro-transcribing viruses envelope glycoprotein HERV-K_REC PF15695.3 T230577_3 - 1.3e-28 98.7 5.6 2.7e-28 97.7 5.6 1.5 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 RVT_thumb PF06817.12 T230577_3 - 4.7e-16 58.1 0.0 1.5e-15 56.5 0.0 1.9 1 0 0 1 1 1 1 Reverse transcriptase thumb domain IN_DBD_C PF00552.19 T230577_3 - 1.2e-06 27.5 1.2 2.9e-06 26.4 1.2 1.6 1 0 0 1 1 1 1 Integrase DNA binding domain GP41 PF00517.15 T230577_3 - 3.5e-06 26.9 2.1 0.0038 17.0 0.0 2.2 2 0 0 2 2 2 2 Retroviral envelope protein DDE_1 PF03184.17 T371839_1 - 5.5e-37 126.9 0.4 7.8e-37 126.4 0.4 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 T371839_2 - 0.015 15.2 0.0 0.035 14.0 0.0 1.6 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain Neur_chan_memb PF02932.14 T276339_3 - 0.34 10.8 5.1 0.51 10.2 5.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EPL1 PF10513.7 T276339_3 - 1.9 8.7 10.6 2.7 8.2 10.6 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like SpoIIP PF07454.9 T276339_3 - 3.9 6.7 10.3 5.7 6.2 10.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.12 T226677_1 - 1.4 7.0 4.8 1.9 6.5 4.8 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.4 T226677_2 - 0.03 13.9 0.2 0.05 13.1 0.2 1.3 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.15 T226677_2 - 0.074 11.7 0.1 0.1 11.2 0.1 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.10 T226677_2 - 9.4 5.8 6.7 17 5.0 6.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Gag_p30 PF02093.14 T172334_2 - 0.022 14.1 0.0 0.037 13.4 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein Gag_p30 PF02093.14 T172334_3 - 3.3e-39 134.5 1.6 3e-19 69.2 0.0 2.2 2 0 0 2 2 2 2 Gag P30 core shell protein Gag_MA PF01140.17 T172334_3 - 4.8e-22 77.9 0.2 9.5e-22 76.9 0.2 1.4 1 0 0 1 1 1 1 Matrix protein (MA), p15 RVP PF00077.18 T172334_3 - 2e-06 27.9 0.0 3.9e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RNase_H PF00075.22 T172334_3 - 5.2e-05 23.3 0.0 9.7e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 RNase H Asp_protease_2 PF13650.4 T172334_3 - 0.012 16.1 0.1 0.023 15.3 0.1 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.4 T172334_3 - 0.045 14.2 0.1 0.081 13.4 0.1 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Transposase_1 PF01359.16 T378388_1 - 4.1e-29 100.1 1.8 6.8e-29 99.4 0.6 1.9 2 0 0 2 2 2 1 Transposase (partial DDE domain) Alpha-2-MRAP_N PF06400.9 T378388_1 - 0.1 12.4 0.1 0.18 11.6 0.1 1.3 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, N-terminal domain RVT_1 PF00078.25 T187869_1 - 4.9e-48 163.4 1.0 7.6e-48 162.8 1.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Transposase_22 PF02994.12 T187869_1 - 3.7e-38 131.2 3.2 6e-38 130.5 3.2 1.3 1 0 0 1 1 1 1 L1 transposable element Transposase_22 PF02994.12 T187869_2 - 5.9e-73 245.7 10.1 1.2e-46 159.1 0.2 3.4 3 0 0 3 3 3 3 L1 transposable element DUF1725 PF08333.9 T187869_2 - 1.1e-06 28.0 0.7 2.4e-06 26.9 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Exo_endo_phos PF03372.21 T187869_3 - 1.1e-09 38.4 0.0 1.9e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 T187869_3 - 1.1e-07 31.6 1.6 2.2e-07 30.6 1.6 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF2203 PF09969.7 T187869_3 - 5.4 7.6 6.4 45 4.7 1.7 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Toxin_18 PF08087.9 T126458_3 - 7.3 6.5 9.6 18 5.3 1.6 3.4 2 0 0 2 2 2 0 Conotoxin O-superfamily rve PF00665.24 T016395_1 - 1.2e-05 25.3 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Ank_2 PF12796.5 T040991_1 - 0.0011 19.4 0.0 0.0022 18.4 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 T040991_1 - 0.0039 17.5 0.0 0.014 15.7 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.4 T040991_1 - 0.0041 17.4 0.0 0.012 16.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.4 T040991_1 - 0.026 14.8 0.0 0.056 13.7 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_4 PF13637.4 T040991_1 - 0.14 12.7 0.1 0.69 10.4 0.1 2.1 2 0 0 2 2 2 0 Ankyrin repeats (many copies) RNase_H PF00075.22 T144460_1 - 9.3e-22 77.6 0.0 1.7e-21 76.8 0.0 1.4 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.25 T144460_1 - 1.5e-11 44.1 0.0 2.4e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.8 T144460_1 - 5.7e-11 42.4 0.8 1.2e-10 41.4 0.8 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger TLV_coat PF00429.17 T144460_1 - 0.00084 18.0 0.6 0.0013 17.3 0.6 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) rve PF00665.24 T144460_3 - 4.1e-09 36.5 0.0 7.3e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Mpp10 PF04006.10 T113555_3 - 1e-13 50.6 0.0 1.3e-13 50.2 0.0 1.0 1 0 0 1 1 1 1 Mpp10 protein Transposase_1 PF01359.16 T330236_2 - 1.5e-18 66.3 0.0 3.6e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) Transposase_1 PF01359.16 T330236_3 - 0.0015 18.2 1.9 0.0033 17.1 1.9 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) Trypan_PARP PF05887.9 T005070_1 - 0.0011 18.9 3.3 0.0015 18.4 3.3 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Lamp PF01299.15 T005070_1 - 5.4 6.3 11.8 8.5 5.7 11.8 1.3 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) RAM PF15320.4 T360893_3 - 0.2 12.1 1.5 0.55 10.7 1.5 1.7 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein Prenyltrans PF00432.19 T249667_3 - 3.5 7.3 6.1 4 7.1 0.4 2.7 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat RnaseA PF00074.18 T100534_1 - 5.5e-05 23.6 2.9 5.5e-05 23.6 2.9 1.5 2 0 0 2 2 2 1 Pancreatic ribonuclease RnaseA PF00074.18 T100534_2 - 0.0002 21.8 0.0 0.00037 20.9 0.0 1.4 1 0 0 1 1 1 1 Pancreatic ribonuclease DUF4815 PF16075.3 T143038_2 - 0.25 9.5 0.3 0.36 8.9 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4815) HTH_32 PF13565.4 T263326_1 - 0.011 16.2 0.0 0.029 14.8 0.0 1.7 1 1 0 1 1 1 0 Homeodomain-like domain Transposase_1 PF01359.16 T263326_3 - 8.6e-20 70.3 0.1 1.8e-19 69.2 0.1 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) MBDa PF16564.3 T167172_3 - 7.6e-30 102.8 4.6 1.5e-29 101.8 4.6 1.5 1 0 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD MBD_C PF14048.4 T167172_3 - 1.1e-17 64.4 0.0 2e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of methyl-CpG binding protein 2 and 3 DUF4560 PF15118.4 T380530_1 - 1.8e-38 130.2 2.7 3.4e-38 129.3 2.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4560) Orn_Arg_deC_N PF02784.14 T007015_2 - 5.1e-12 45.7 0.0 7.2e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 T007015_2 - 4.8e-11 42.6 0.0 8.2e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain ketoacyl-synt PF00109.24 T038772_2 - 5.6e-13 48.9 0.5 7.9e-13 48.4 0.5 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ketoacyl-synt PF00109.24 T038772_3 - 7.7e-16 58.3 0.0 1.1e-15 57.8 0.0 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain DUF3704 PF12488.6 T038772_3 - 0.92 9.1 6.5 0.1 12.1 2.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3704) RS4NT PF08071.10 T194285_2 - 7.5 6.6 16.2 42 4.2 0.1 5.9 6 0 0 6 6 6 0 RS4NT (NUC023) domain Pentapeptide_2 PF01469.16 T051567_1 - 0.008 15.9 6.1 0.17 11.7 3.5 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) RabGAP-TBC PF00566.16 T362461_2 - 8.3e-06 25.5 0.0 1.2e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Trypsin PF00089.24 T362461_3 - 8.1e-32 110.7 0.0 1.1e-31 110.2 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 T362461_3 - 1.9e-09 37.8 0.4 2.7e-09 37.3 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF1510 PF07423.9 T281045_1 - 0.24 10.7 26.2 0.38 10.0 26.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) MIP-T3 PF10243.7 T281045_2 - 0.072 11.7 39.0 0.1 11.2 39.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CDC45 PF02724.12 T281045_2 - 4.2 5.4 20.7 5.9 4.9 20.7 1.1 1 0 0 1 1 1 0 CDC45-like protein MIP-T3 PF10243.7 T281045_3 - 0.52 8.8 37.5 0.74 8.3 37.5 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DDHD PF02862.15 T281045_3 - 3.6 7.5 5.6 5.5 6.9 5.6 1.2 1 0 0 1 1 1 0 DDHD domain AAA_11 PF13086.4 T281045_3 - 8.2 5.9 13.0 13 5.3 13.0 1.1 1 0 0 1 1 1 0 AAA domain RVP PF00077.18 T270476_2 - 0.0012 19.0 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Gag_p30 PF02093.14 T270476_2 - 0.0035 16.8 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T270476_2 - 0.0049 16.3 0.0 0.0081 15.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T270476_2 - 0.081 12.9 5.4 0.23 11.5 5.4 1.9 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.4 T270476_2 - 1 9.1 11.5 0.45 10.2 4.3 2.8 2 0 0 2 2 2 0 Zinc knuckle Herpes_BLLF1 PF05109.11 T270476_3 - 1.1 7.0 7.1 1.6 6.5 7.1 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) RVT_1 PF00078.25 T266342_1 - 3e-11 43.2 2.8 1.1e-05 25.0 0.5 3.3 3 1 0 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.18 T266342_1 - 1.2e-08 35.0 0.0 2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease TLV_coat PF00429.17 T266342_2 - 1.4e-63 215.3 6.5 2.1e-63 214.8 6.5 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Transposase_22 PF02994.12 T266342_2 - 1.4e-25 89.8 3.0 2.2e-25 89.1 3.0 1.2 1 0 0 1 1 1 1 L1 transposable element Gag_p30 PF02093.14 T266342_3 - 1.1e-22 80.4 0.0 1.7e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein RVT_1 PF00078.25 T266342_3 - 6.2e-08 32.3 0.1 8.8e-08 31.8 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.21 T266342_3 - 0.0048 16.8 1.3 0.0048 16.8 1.3 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.4 T266342_3 - 0.18 11.4 0.7 0.43 10.2 0.7 1.7 1 0 0 1 1 1 0 Zinc knuckle TPR_16 PF13432.4 T035018_1 - 0.0076 16.8 0.1 13 6.4 0.0 3.8 2 1 2 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.4 T035018_2 - 0.019 15.5 0.4 24 5.6 0.0 3.6 2 1 2 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.4 T035018_3 - 0.0087 16.6 3.0 4.2 8.0 0.1 3.8 1 1 2 4 4 4 3 Tetratricopeptide repeat Transposase_22 PF02994.12 T103724_2 - 2.1e-142 474.2 20.5 2.9e-142 473.8 20.5 1.2 1 0 0 1 1 1 1 L1 transposable element Exo_endo_phos PF03372.21 T103724_2 - 0.03 14.4 0.0 0.056 13.6 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IncA PF04156.12 T103724_2 - 0.06 13.0 10.5 0.11 12.1 10.5 1.3 1 0 0 1 1 1 0 IncA protein Spectrin PF00435.19 T103724_2 - 0.061 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat Syntaxin-6_N PF09177.9 T103724_2 - 0.34 11.3 5.0 0.69 10.4 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103724_2 - 0.42 9.8 12.3 0.74 9.0 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103724_2 - 1.2 9.2 11.4 0.014 15.4 2.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 KLRAQ PF10205.7 T103724_2 - 3 8.0 7.5 5.3 7.2 6.7 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein RVT_1 PF00078.25 T325361_3 - 1.8e-15 56.9 0.0 2.9e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ELM2 PF01448.22 T076685_1 - 0.14 12.9 0.3 1.2e+02 3.4 0.0 4.3 4 0 0 4 4 4 0 ELM2 domain DUF1838 PF08894.9 T076685_1 - 2.5 7.6 3.5 8.3 5.9 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1838) zf-CCHC_5 PF14787.4 T254937_1 - 4.5 6.9 14.8 7.3 6.3 5.4 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Plasmodium_Vir PF05795.9 T305702_3 - 0.028 13.7 8.1 0.041 13.2 8.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Lambda_Kil PF06301.9 T235903_1 - 0.044 13.3 0.4 15 5.1 0.1 3.1 3 0 0 3 3 3 0 Bacteriophage lambda Kil protein YtxH PF12732.5 T235903_2 - 0.15 12.5 0.0 25 5.4 0.0 2.3 2 0 0 2 2 2 0 YtxH-like protein Transposase_22 PF02994.12 T253972_2 - 1.2e-70 238.1 6.2 2.3e-70 237.2 6.2 1.4 1 0 0 1 1 1 1 L1 transposable element RVT_1 PF00078.25 T253972_2 - 3e-41 141.2 4.4 5.3e-41 140.4 4.4 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T314345_1 - 0.046 13.3 1.2 0.14 11.7 1.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) zf-H2C2_2 PF13465.4 T364932_3 - 5.9e-84 272.9 112.9 8.4e-09 35.4 0.1 15.1 15 0 0 15 15 15 12 Zinc-finger double domain zf-C2H2 PF00096.24 T364932_3 - 1.1e-56 186.1 120.9 4.7e-07 29.8 0.7 14.6 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 T364932_3 - 8.2e-25 85.2 124.4 0.0063 17.1 0.5 15.3 15 0 0 15 15 15 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 T364932_3 - 3.2e-18 65.1 100.1 0.0076 16.0 0.7 14.1 14 0 0 14 14 14 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 T364932_3 - 1.1e-06 28.6 54.9 0.079 13.2 0.4 11.3 11 0 0 11 11 11 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 T364932_3 - 0.0059 16.6 80.5 0.026 14.5 3.1 9.5 3 2 9 13 13 13 8 Zinc ribbon domain zf-C2H2_11 PF16622.3 T364932_3 - 0.38 10.4 71.4 0.11 12.2 0.2 12.5 12 0 0 12 12 12 0 zinc-finger C2H2-type Transposase_22 PF02994.12 T103717_1 - 2.8e-165 549.5 32.1 7.4e-142 472.4 20.5 2.2 2 0 0 2 2 2 2 L1 transposable element Exo_endo_phos PF03372.21 T103717_1 - 0.0052 16.9 0.0 0.13 12.4 0.0 2.3 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Spectrin PF00435.19 T103717_1 - 0.14 12.6 2.8 0.25 11.7 2.8 1.4 1 0 0 1 1 1 0 Spectrin repeat IncA PF04156.12 T103717_1 - 0.15 11.7 10.5 0.26 10.9 10.5 1.3 1 0 0 1 1 1 0 IncA protein Syntaxin-6_N PF09177.9 T103717_1 - 0.75 10.3 5.0 1.6 9.2 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal GAS PF13851.4 T103717_1 - 0.98 8.6 12.3 1.7 7.8 12.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med2 PF11214.6 T103717_1 - 9.4 6.3 12.2 0.034 14.2 2.1 2.1 2 0 0 2 2 2 0 Mediator complex subunit 2 DUF1725 PF08333.9 T103717_2 - 0.00085 18.8 0.1 0.00085 18.8 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) Transposase_22 PF02994.12 T103717_3 - 2.9e-63 213.8 26.2 3.3e-56 190.6 2.0 3.1 3 0 0 3 3 3 3 L1 transposable element RVT_1 PF00078.25 T103717_3 - 3.7e-12 46.1 0.0 6.3e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF716 PF04819.10 T256132_2 - 0.00072 19.2 0.8 0.0014 18.2 0.8 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF716) zf-H2C2 PF09337.8 T268135_2 - 2.4e-07 30.7 0.2 6e-07 29.5 0.2 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve PF00665.24 T268135_2 - 0.0028 17.7 0.0 0.0072 16.4 0.0 1.6 1 1 0 1 1 1 1 Integrase core domain RNase_H PF00075.22 T268135_3 - 7.3e-11 42.3 0.0 1.3e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 RNase H Gag_p30 PF02093.14 T226507_1 - 3.8e-12 46.1 0.0 5.6e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Gag P30 core shell protein rve PF00665.24 T226507_1 - 0.12 12.4 0.1 0.24 11.5 0.1 1.3 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.25 T226507_2 - 0.084 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1725 PF08333.9 T226507_3 - 0.00016 21.1 0.6 0.00016 21.1 0.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) # # Program: hmmscan # Version: 3.1b2 (February 2015) # Pipeline mode: SCAN # Query file: /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/mitrans_tucp/wd/mitrans_tucp_5000.p.fa # Target file: /home/yduan/database/Pfam/Pfam-A.hmm # Option settings: hmmscan -o /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/mitrans_tucp/hmmscan.outm --tblout /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/mitrans_tucp/hmmscan.t.out /home/yduan/database/Pfam/Pfam-A.hmm /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/mitrans_tucp/wd/mitrans_tucp_5000.p.fa # Current dir: /home/yduan/work_file/lncRNAdb/methods_assement # Date: Thu Jul 5 16:38:13 2018 # [ok]