# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DSPc PF00782.18 NM_001304794.1_2 - 1.7e-32 111.9 0.1 2.5e-32 111.4 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 NM_001304794.1_2 - 0.015 14.7 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase CBS PF00571.26 NM_001304527.1_1 - 9.4e-31 105.9 4.2 1.1e-08 35.3 0.1 4.3 4 0 0 4 4 4 4 CBS domain FMO-like PF00743.17 NM_001319174.1_1 - 2.6e-252 837.8 0.4 8.1e-230 763.6 0.0 2.0 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 NM_001319174.1_1 - 1.1e-13 50.9 0.1 7.7e-09 35.1 0.0 3.0 2 1 2 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 NM_001319174.1_1 - 2.4e-09 36.7 0.0 2.3e-05 23.7 0.0 3.0 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 NM_001319174.1_1 - 4e-09 35.9 0.2 1.3e-06 27.7 0.0 3.0 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.4 NM_001319174.1_1 - 9.5e-06 25.6 0.0 4e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 NM_001319174.1_1 - 7.5e-05 23.1 0.1 0.023 15.1 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 NM_001319174.1_1 - 0.00029 20.5 0.0 0.2 11.1 0.0 3.5 3 1 1 4 4 4 1 FAD dependent oxidoreductase Shikimate_DH PF01488.18 NM_001319174.1_1 - 0.0045 16.9 0.2 0.2 11.6 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.17 NM_001319174.1_1 - 0.012 14.9 0.2 4.4 6.5 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.10 NM_001319174.1_1 - 0.012 15.0 0.0 1.7 8.1 0.0 2.6 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.4 NM_001319174.1_1 - 0.029 14.7 0.0 4 7.8 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.19 NM_001319174.1_1 - 0.04 13.1 0.0 0.15 11.2 0.0 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.4 NM_001319174.1_1 - 0.045 13.6 0.3 6.8 6.5 0.0 3.1 2 1 1 3 3 3 0 FAD-NAD(P)-binding Thi4 PF01946.15 NM_001319174.1_1 - 0.048 12.8 0.0 0.87 8.6 0.0 2.1 2 0 0 2 2 2 0 Thi4 family HAT_KAT11 PF08214.9 NM_004380.2_1 - 6.5e-69 232.7 0.5 1.5e-68 231.5 0.5 1.6 1 0 0 1 1 1 1 Histone acetylation protein KIX PF02172.14 NM_004380.2_1 - 5.7e-39 132.1 0.4 1.1e-38 131.2 0.4 1.5 1 0 0 1 1 1 1 KIX domain Creb_binding PF09030.8 NM_004380.2_1 - 1.3e-33 115.8 16.2 1.3e-33 115.8 16.2 10.9 7 1 2 9 9 9 1 Creb binding zf-TAZ PF02135.14 NM_004380.2_1 - 6.4e-28 96.9 71.5 9.1e-19 67.6 20.6 3.7 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.11 NM_004380.2_1 - 1.1e-21 76.8 9.1 1.1e-21 76.8 9.1 2.4 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.23 NM_004380.2_1 - 1.3e-16 60.2 0.1 3.2e-16 59.0 0.1 1.6 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.15 NM_004380.2_1 - 3.6e-15 55.3 14.0 3.6e-15 55.3 14.0 3.0 3 0 0 3 3 3 1 Zinc finger, ZZ type KIX_2 PF16987.3 NM_004380.2_1 - 7.1e-05 22.6 0.1 7.1e-05 22.6 0.1 2.2 2 0 0 2 2 2 1 KIX domain Npa1 PF11707.6 NM_004380.2_1 - 0.0073 15.6 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal BAR PF03114.16 NM_001321164.1_1 - 2.3e-66 223.7 9.3 3.7e-66 223.1 9.3 1.3 1 0 0 1 1 1 1 BAR domain RhoGAP PF00620.25 NM_001321164.1_1 - 7.6e-45 152.3 0.2 2.7e-44 150.5 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain DUF1018 PF06252.10 NM_001321164.1_1 - 0.078 13.9 0.0 0.24 12.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) BAR_3 PF16746.3 NM_001321164.1_1 - 0.21 11.1 3.7 0.3 10.6 0.8 2.3 2 1 0 2 2 2 0 BAR domain of APPL family Cadherin PF00028.15 NM_004360.4_1 - 5.9e-82 270.1 11.9 4.5e-22 78.2 0.2 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_C PF01049.15 NM_004360.4_1 - 2.3e-46 157.2 0.4 4.1e-46 156.4 0.4 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_pro PF08758.9 NM_004360.4_1 - 2.6e-31 107.5 0.0 9.2e-31 105.7 0.0 2.0 2 0 0 2 2 2 1 Cadherin prodomain like Cadherin_2 PF08266.10 NM_004360.4_1 - 0.00014 21.5 0.0 3.4 7.4 0.0 3.5 3 0 0 3 3 3 2 Cadherin-like Cadherin_3 PF16184.3 NM_004360.4_1 - 0.28 11.1 6.6 0.98 9.3 0.4 3.3 3 0 0 3 3 3 0 Cadherin-like DNA_methylase PF00145.15 NM_001318731.1_2 - 3.6e-47 161.2 0.0 3.6e-47 161.2 0.0 2.9 2 2 0 2 2 2 1 C-5 cytosine-specific DNA methylase DNMT1-RFD PF12047.6 NM_001318731.1_2 - 5.3e-47 159.4 0.0 1.4e-46 157.9 0.0 1.8 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain BAH PF01426.16 NM_001318731.1_2 - 6e-46 155.1 0.0 1e-21 76.9 0.0 2.5 2 0 0 2 2 2 2 BAH domain zf-CXXC PF02008.18 NM_001318731.1_2 - 1.8e-14 53.3 21.5 1.8e-14 53.3 21.5 2.5 2 0 0 2 2 2 1 CXXC zinc finger domain DMAP_binding PF06464.9 NM_001318731.1_3 - 1.5e-13 51.4 1.0 1.5e-13 51.4 1.0 2.7 2 0 0 2 2 2 1 DMAP1-binding Domain HTH_12 PF08461.8 NM_001318731.1_3 - 0.55 10.1 2.8 0.25 11.2 0.1 1.8 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain GoLoco PF02188.15 NM_001321038.1_1 - 1.4e-38 129.7 32.1 6.3e-10 38.2 0.2 4.5 4 0 0 4 4 4 4 GoLoco motif TPR_12 PF13424.4 NM_001321038.1_1 - 3.9e-38 129.5 28.6 5.2e-11 42.5 5.7 5.5 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001321038.1_1 - 1.6e-34 116.1 29.5 7.2e-06 25.5 0.0 7.9 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001321038.1_1 - 2.5e-29 99.0 19.8 1.1e-05 24.9 0.4 8.2 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001321038.1_1 - 5.1e-21 72.9 22.2 0.0016 18.2 0.7 7.9 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001321038.1_1 - 7.9e-20 69.2 19.9 0.00043 20.2 0.5 7.7 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001321038.1_1 - 3.1e-18 64.9 21.0 0.0072 16.1 0.0 8.1 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_4 PF07721.12 NM_001321038.1_1 - 2.2e-08 33.8 0.0 0.82 10.4 0.1 6.2 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001321038.1_1 - 1.6e-05 25.1 5.1 16 6.5 0.0 7.0 5 2 2 7 7 7 0 Tetratricopeptide repeat Rapsyn_N PF10579.7 NM_001321038.1_1 - 2.9e-05 24.0 0.9 7.4 6.6 0.1 4.6 3 2 2 5 5 5 2 Rapsyn N-terminal myristoylation and linker region TPR_16 PF13432.4 NM_001321038.1_1 - 0.00017 22.0 11.5 1.3 9.7 0.2 6.0 4 1 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001321038.1_1 - 0.0068 16.6 13.9 26 5.4 0.0 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001321038.1_1 - 0.0091 16.4 2.1 68 4.3 0.1 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001321038.1_1 - 0.05 13.2 24.0 0.33 10.5 0.4 7.0 6 2 1 7 7 7 0 TPR repeat ANAPC3 PF12895.5 NM_001321038.1_1 - 0.052 13.6 12.1 3.1 7.9 1.8 4.6 3 1 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 PK PF00224.19 NM_001206796.2_2 - 1.5e-171 569.8 2.0 1.9e-171 569.5 2.0 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 NM_001206796.2_2 - 1.2e-33 115.7 0.0 2.6e-33 114.6 0.0 1.6 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 NM_001206796.2_2 - 0.0021 17.1 0.4 0.0082 15.2 0.1 2.0 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Fez1 PF06818.13 NM_021020.3_1 - 9.2e-64 215.4 24.3 9.2e-64 215.4 24.3 2.2 2 0 0 2 2 2 2 Fez1 PEARLI-4 PF05278.10 NM_021020.3_1 - 0.97 8.8 13.1 0.5 9.8 1.8 2.5 1 1 1 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) Lectin_N PF03954.12 NM_080913.3_1 - 5.3e-56 187.8 2.6 8.1e-56 187.2 2.6 1.2 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain Lectin_C PF00059.19 NM_080913.3_1 - 2.7e-26 92.3 7.7 5e-26 91.4 5.7 2.2 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 NM_080913.3_1 - 0.084 12.4 0.3 0.29 10.6 0.4 1.8 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like Mlf1IP PF10248.7 NM_001130157.2_3 - 4.7e-74 247.8 10.4 6.3e-74 247.4 10.4 1.2 1 0 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein KH_1 PF00013.27 NM_203304.3_1 - 4.3e-25 87.2 2.0 7.4e-13 48.0 0.1 2.5 2 0 0 2 2 2 2 KH domain zf-C3HC4_3 PF13920.4 NM_203304.3_1 - 2.6e-10 39.8 8.8 2.6e-10 39.8 8.8 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_203304.3_1 - 3e-05 24.1 9.2 5.8e-05 23.1 9.2 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.4 NM_203304.3_1 - 0.00038 20.1 9.9 0.00068 19.3 9.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.23 NM_203304.3_1 - 0.0018 18.0 8.9 0.0032 17.2 8.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) KH_2 PF07650.15 NM_203304.3_1 - 0.011 15.5 0.1 1.5 8.6 0.0 2.3 2 0 0 2 2 2 0 KH domain zf-RING_4 PF14570.4 NM_203304.3_1 - 0.014 15.0 3.5 0.026 14.1 3.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain KH_4 PF13083.4 NM_203304.3_1 - 0.027 14.2 0.0 3.7 7.4 0.0 2.3 2 0 0 2 2 2 0 KH domain zf-RING_5 PF14634.4 NM_203304.3_1 - 1.2 9.0 8.5 2.3 8.1 8.5 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.4 NM_203304.3_1 - 9.5 6.3 10.1 20 5.3 10.1 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING CutA1 PF03091.13 NM_001014838.1_1 - 1.6e-39 133.6 0.2 2.2e-39 133.2 0.2 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein DAHP_synth_1 PF00793.18 NM_001014838.1_1 - 0.038 12.7 0.0 0.053 12.2 0.0 1.1 1 0 0 1 1 1 0 DAHP synthetase I family 6PF2K PF01591.16 NM_002625.3_3 - 6.3e-104 346.0 0.1 9.9e-104 345.4 0.1 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 NM_002625.3_3 - 2.8e-42 144.5 0.0 3.8e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 NM_002625.3_3 - 1.1e-07 32.0 0.0 2.5e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 NM_002625.3_3 - 0.0019 17.4 0.0 0.0043 16.2 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin KTI12 PF08433.8 NM_002625.3_3 - 0.0091 15.3 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Thioredoxin PF00085.18 NM_030755.4_3 - 9.7e-21 73.5 0.0 1.5e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin FAM176 PF14851.4 NM_030755.4_3 - 0.027 14.0 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 FAM176 family HSP20 PF00011.19 NM_006308.2_1 - 3.1e-15 56.1 0.0 4.5e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Dynein_IC2 PF11540.6 NM_001278422.1_2 - 7.5e-15 54.4 0.1 1.9e-14 53.2 0.1 1.7 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 NM_001278422.1_2 - 9e-07 29.4 8.6 0.13 13.0 0.3 6.2 7 0 0 7 7 7 2 WD domain, G-beta repeat AviRa PF11599.6 NM_001278422.1_2 - 0.12 11.8 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa ANAPC4_WD40 PF12894.5 NM_001278422.1_2 - 0.15 12.2 0.4 1.1 9.5 0.1 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Vfa1 PF08432.8 NM_001278422.1_2 - 6.1 7.0 19.6 8.7 6.5 11.0 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Asp-B-Hydro_N PF05279.9 NM_001278422.1_2 - 9.9 6.0 20.7 9.5 6.1 6.0 2.1 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Cullin_binding PF03556.13 NM_001318739.1_3 - 7e-28 97.3 4.4 1.2e-27 96.6 4.4 1.4 1 0 0 1 1 1 1 Cullin binding LRR_8 PF13855.4 NM_001145077.1_2 - 1.2e-16 60.0 2.5 4.1e-08 32.7 0.3 3.5 2 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_001145077.1_2 - 3.5e-15 55.7 0.2 0.00046 20.4 0.0 4.5 3 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_001145077.1_2 - 4.3e-05 22.9 0.0 0.25 10.7 0.1 2.3 1 1 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.31 NM_001145077.1_2 - 0.017 15.4 9.6 56 4.7 0.2 6.6 6 1 0 6 6 6 0 Leucine Rich Repeat RsmF_methylt_CI PF17126.3 NM_001145077.1_2 - 0.024 14.5 0.3 32 4.5 0.0 3.9 3 1 0 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain Adap_comp_sub PF00928.19 NM_001320264.1_2 - 2.1e-74 250.1 0.0 2.7e-74 249.8 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.18 NM_001320264.1_2 - 1.6e-05 24.7 0.1 2.7e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Pro-MCH PF05824.10 NM_002674.3_1 - 1.3e-50 169.2 0.0 2.3e-50 168.4 0.0 1.4 1 0 0 1 1 1 1 Pro-melanin-concentrating hormone (Pro-MCH) PGC7_Stella PF15549.4 NM_001321182.1_1 - 1.4e-74 249.4 1.8 1.4e-74 249.4 1.8 2.1 1 1 1 2 2 2 2 PGC7/Stella/Dppa3 domain Herpes_UL92 PF03048.12 NM_001321182.1_1 - 1.1 8.9 6.8 1.7 8.3 6.8 1.2 1 0 0 1 1 1 0 UL92 family GalP_UDP_tr_C PF02744.15 NM_000155.3_3 - 7.4e-69 230.6 0.3 1.3e-68 229.8 0.3 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain GalP_UDP_transf PF01087.20 NM_000155.3_3 - 4.1e-65 219.5 0.0 6.5e-65 218.9 0.0 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain HIT PF01230.21 NM_000155.3_3 - 0.00044 20.8 0.0 0.0013 19.3 0.0 1.9 2 1 0 2 2 2 1 HIT domain COX3 PF00510.16 NM_001321022.1_2 - 2.3 7.9 5.7 1.4 8.5 1.3 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase subunit III Ribosomal_L40e PF01020.15 NM_001321022.1_3 - 6.8e-32 109.0 12.3 1.6e-31 107.8 12.3 1.7 1 0 0 1 1 1 1 Ribosomal L40e family ubiquitin PF00240.21 NM_001321022.1_3 - 4e-10 39.1 0.3 8.1e-10 38.2 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 NM_001321022.1_3 - 0.056 13.1 0.2 0.09 12.5 0.2 1.2 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Toxin_18 PF08087.9 NM_001321022.1_3 - 0.071 13.0 0.4 0.071 13.0 0.4 3.4 3 0 0 3 3 3 0 Conotoxin O-superfamily IRF-2BP1_2 PF11261.6 NM_133179.2_1 - 0.04 13.3 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 Interferon regulatory factor 2-binding protein zinc finger GAGE PF05831.9 NM_133179.2_2 - 7.2e-43 145.3 9.6 8.9e-43 145.0 9.6 1.1 1 0 0 1 1 1 1 GAGE protein Adaptin_binding PF10199.7 NM_133179.2_2 - 0.038 14.5 0.8 0.063 13.7 0.8 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 N6-adenineMlase PF10237.7 NM_001318939.1_1 - 1.3e-56 190.7 0.0 1.6e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Cons_hypoth95 PF03602.13 NM_001318939.1_1 - 0.0029 17.1 0.0 0.0073 15.8 0.0 1.6 2 0 0 2 2 2 1 Conserved hypothetical protein 95 GRASP55_65 PF04495.12 NM_001278789.1_3 - 2e-35 121.9 0.0 3.2e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain CD20 PF04103.13 NM_001101312.1_2 - 2.1e-43 148.0 7.3 3e-43 147.5 7.3 1.2 1 0 0 1 1 1 1 CD20-like family TIR_2 PF13676.4 NM_001172566.1_1 - 2.8e-05 24.2 0.0 5.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 TIR domain TIR PF01582.18 NM_001172566.1_1 - 4.9e-05 23.1 0.0 0.00012 21.9 0.0 1.6 1 1 0 1 1 1 1 TIR domain Hairy_orange PF07527.11 NM_001172566.1_1 - 0.049 13.7 0.1 1 9.5 0.0 2.7 2 0 0 2 2 2 0 Hairy Orange Death PF00531.20 NM_001172566.1_2 - 2.4e-13 49.9 0.1 4.5e-13 49.1 0.1 1.4 1 0 0 1 1 1 1 Death domain APOBEC_N PF08210.9 NM_005889.3_1 - 2.9e-28 98.9 0.2 4.4e-28 98.3 0.2 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 NM_005889.3_1 - 3.1e-24 84.6 0.1 7.1e-24 83.4 0.1 1.6 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 NM_005889.3_1 - 0.0062 16.3 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region F-box PF00646.31 NM_174899.4_3 - 2.3e-08 33.5 0.8 4.8e-08 32.5 0.8 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 NM_174899.4_3 - 3.4e-07 29.9 1.1 8.1e-07 28.7 1.1 1.7 1 0 0 1 1 1 1 F-box-like Myosin_head PF00063.19 NM_001300899.1_2 - 1.9e-239 796.3 6.3 1.9e-239 796.3 6.3 1.6 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin-VI_CBD PF16521.3 NM_001300899.1_2 - 2.1e-43 146.2 0.3 9.7e-43 144.1 0.0 2.4 3 0 0 3 3 3 1 Myosin VI cargo binding domain BUD22 PF09073.8 NM_001300899.1_2 - 0.00032 20.0 25.0 0.00049 19.4 25.0 1.1 1 0 0 1 1 1 1 BUD22 Myosin_N PF02736.17 NM_001300899.1_2 - 0.0017 18.0 0.0 0.0032 17.1 0.0 1.4 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 NM_001300899.1_2 - 0.014 15.0 1.2 0.042 13.5 1.2 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif PseudoU_synth_2 PF00849.20 NM_001300899.1_2 - 3.6 7.5 6.6 10 6.0 6.6 1.8 1 0 0 1 1 1 0 RNA pseudouridylate synthase Macoilin PF09726.7 NM_001300899.1_2 - 6 5.2 36.7 9.6 4.5 36.7 1.2 1 0 0 1 1 1 0 Transmembrane protein DDHD PF02862.15 NM_001300899.1_2 - 9.5 6.1 11.1 19 5.1 11.1 1.5 1 0 0 1 1 1 0 DDHD domain PET PF06297.12 NM_001278235.1_1 - 1.2e-36 124.8 0.1 1.9e-36 124.1 0.1 1.3 1 0 0 1 1 1 1 PET Domain bZIP_1 PF00170.19 NM_005253.3_3 - 2.3e-08 33.9 20.3 4.6e-08 32.9 20.3 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_005253.3_3 - 3.7e-05 23.6 19.6 3.7e-05 23.6 19.6 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_005253.3_3 - 0.00022 21.6 15.0 0.00022 21.6 15.0 2.0 2 0 0 2 2 2 1 bZIP Maf transcription factor APG6 PF04111.10 NM_005253.3_3 - 1.7 7.8 9.7 2.5 7.3 9.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Macoilin PF09726.7 NM_005253.3_3 - 2.9 6.2 12.6 5.1 5.4 12.6 1.3 1 0 0 1 1 1 0 Transmembrane protein IncA PF04156.12 NM_005253.3_3 - 4.4 6.9 8.0 6.9 6.3 8.0 1.2 1 0 0 1 1 1 0 IncA protein DivIC PF04977.13 NM_005253.3_3 - 5.7 6.7 5.8 11 5.8 5.8 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF4527 PF15030.4 NM_005253.3_3 - 7.2 5.9 10.4 12 5.1 10.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) Nnf1 PF03980.12 NM_001199664.1_2 - 2.5e-06 27.7 0.0 4.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Nnf1 TraC_F_IV PF11130.6 NM_001199664.1_2 - 0.028 13.9 0.1 0.039 13.4 0.1 1.1 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer CASP_C PF08172.10 NM_001199664.1_2 - 0.051 12.8 0.2 0.067 12.4 0.2 1.1 1 0 0 1 1 1 0 CASP C terminal LRS4 PF10422.7 NM_001199664.1_2 - 0.48 9.8 2.6 0.74 9.2 2.6 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Tubulin PF00091.23 NM_024803.2_3 - 1.7e-61 207.8 0.0 2.1e-61 207.4 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_024803.2_3 - 3.3e-48 162.9 0.0 5e-48 162.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 NM_024803.2_3 - 0.0032 17.0 0.0 0.0071 15.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Flavoprotein PF02441.17 NM_001301101.1_1 - 1.9e-24 86.1 0.0 5.8e-13 48.8 0.0 2.2 1 1 1 2 2 2 2 Flavoprotein DUF3935 PF13071.4 NM_001301101.1_1 - 0.14 12.7 0.0 6.3 7.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3935) Aldedh PF00171.20 NM_153329.3_3 - 1.3e-117 393.1 0.0 2.1e-82 276.9 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.9 NM_153329.3_3 - 0.00041 19.7 0.0 0.18 11.1 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF1487) SDH_alpha PF03313.13 NM_153329.3_3 - 0.059 12.9 0.7 0.64 9.5 0.1 2.2 2 0 0 2 2 2 0 Serine dehydratase alpha chain mit_SMPDase PF14724.4 NM_001171083.2_1 - 0 1258.1 7.2 1.3e-264 879.7 0.0 3.0 1 1 2 3 3 3 3 Mitochondrial-associated sphingomyelin phosphodiesterase BTB_3 PF16017.3 NM_001286580.1_1 - 5e-33 113.2 0.0 9.2e-33 112.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain PDZ PF00595.22 NM_001080423.3_3 - 1.6e-88 291.0 0.3 3.8e-12 46.2 0.1 7.5 7 0 0 7 7 7 7 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001080423.3_3 - 1.4e-35 121.4 0.3 7e-05 22.9 0.0 7.4 7 0 0 7 7 7 7 PDZ domain GRASP55_65 PF04495.12 NM_001080423.3_3 - 0.0016 18.6 0.0 8.7 6.5 0.0 4.2 4 1 1 5 5 5 2 GRASP55/65 PDZ-like domain Trypan_PARP PF05887.9 NM_001080423.3_3 - 2.9 7.8 9.7 5.7 6.8 9.7 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pkinase PF00069.23 NM_212503.2_2 - 4e-69 232.8 0.0 5.5e-69 232.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_212503.2_2 - 2.3e-32 112.2 0.0 3.1e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_212503.2_2 - 4e-06 26.2 0.0 6.2e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 NM_212503.2_2 - 0.017 14.9 0.3 0.11 12.2 0.3 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.9 NM_212503.2_2 - 0.029 13.3 0.1 0.047 12.6 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.12 NM_212503.2_2 - 0.034 13.4 0.4 0.092 11.9 0.4 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PID PF00640.21 NM_001202859.1_3 - 9.6e-47 158.4 0.0 1.4e-46 157.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.22 NM_001202859.1_3 - 2.1e-17 62.8 0.0 3.3e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 SH2 domain Delta_lysin PF05372.9 NM_001202859.1_3 - 0.18 11.0 0.1 0.36 10.0 0.1 1.5 1 0 0 1 1 1 0 Delta lysin family 7tm_1 PF00001.19 NM_178445.2_1 - 6.2e-46 156.7 29.2 2.2e-45 154.8 29.2 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_178445.2_1 - 0.0017 17.7 25.8 0.0027 17.0 25.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Lectin_C PF00059.19 NM_002909.4_2 - 3.3e-22 79.1 0.3 5e-22 78.5 0.3 1.3 1 0 0 1 1 1 1 Lectin C-type domain zf-RING_UBOX PF13445.4 NM_187841.2_1 - 3.1e-10 39.7 4.0 1.2e-09 37.9 4.0 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_187841.2_1 - 2.5e-08 33.5 2.7 2.5e-08 33.5 2.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_187841.2_1 - 3.4e-07 29.9 4.0 3.4e-07 29.9 4.0 2.8 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_187841.2_1 - 9.6e-07 28.5 5.0 9.6e-07 28.5 5.0 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_187841.2_1 - 2e-06 27.8 5.6 2e-06 27.8 5.6 2.6 2 0 0 2 2 1 1 Ring finger domain zf-B_box PF00643.22 NM_187841.2_1 - 6e-06 26.2 8.1 6e-06 26.2 8.1 3.4 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4_4 PF15227.4 NM_187841.2_1 - 1.2e-05 25.2 6.3 1.2e-05 25.2 6.3 2.8 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 NM_187841.2_1 - 2.9e-05 23.7 7.9 2.9e-05 23.7 7.9 3.1 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 NM_187841.2_1 - 0.00018 21.2 0.3 0.00018 21.2 0.3 2.0 2 0 0 2 2 2 1 zf-RING of BARD1-type protein DUF349 PF03993.10 NM_187841.2_1 - 0.01 16.0 1.2 0.029 14.5 1.2 1.8 1 1 0 1 1 1 0 Domain of Unknown Function (DUF349) UvrD_C PF13361.4 NM_187841.2_1 - 0.086 12.1 0.4 0.12 11.5 0.4 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Fmp27_WPPW PF10359.7 NM_187841.2_1 - 0.1 11.3 1.9 0.15 10.7 1.9 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF2431 PF10354.7 NM_187841.2_1 - 0.12 12.6 0.1 0.21 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) zf-RING_11 PF17123.3 NM_187841.2_1 - 3.5 7.3 10.0 2.1 8.0 6.2 2.5 2 0 0 2 2 2 0 RING-like zinc finger Evr1_Alr PF04777.11 NM_001004128.2_1 - 1.8e-25 89.2 0.3 5.1e-25 87.8 0.3 1.8 2 0 0 2 2 2 1 Erv1 / Alr family Thioredoxin PF00085.18 NM_001004128.2_1 - 1.3e-16 60.3 0.0 3.7e-15 55.6 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.4 NM_001004128.2_1 - 0.018 15.3 0.0 1.9 8.8 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin-like domain Thioredoxin_8 PF13905.4 NM_001004128.2_1 - 0.022 14.9 0.0 0.35 11.1 0.0 2.5 2 1 0 2 2 2 0 Thioredoxin-like Thioredoxin_7 PF13899.4 NM_001004128.2_1 - 0.081 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like DUF35_N PF12172.6 NM_001004128.2_1 - 0.09 12.5 0.1 0.09 12.5 0.1 2.5 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) wnt PF00110.17 NM_025216.2_2 - 7.5e-119 396.6 7.9 9e-119 396.4 7.9 1.1 1 0 0 1 1 1 1 wnt family TRAM_LAG1_CLN8 PF03798.14 NM_001160407.1_1 - 3.2e-16 59.5 10.4 3.7e-16 59.3 10.4 1.1 1 0 0 1 1 1 1 TLC domain 7tm_1 PF00001.19 NM_176072.2_1 - 1.9e-37 128.8 17.4 3e-37 128.2 17.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) RepA1_leader PF08048.10 NM_005951.2_1 - 0.17 12.0 0.8 0.27 11.4 0.8 1.3 1 0 0 1 1 1 0 Tap RepA1 leader peptide Rib_recp_KP_reg PF05104.10 NM_005951.2_1 - 1.8 9.5 10.8 2.2 9.2 10.8 1.1 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region CAP_N PF01213.17 NM_005951.2_1 - 9.9 5.4 7.1 12 5.2 7.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Metallothio PF00131.18 NM_005951.2_3 - 4.6e-19 68.2 63.9 5.7e-19 67.9 63.9 1.1 1 0 0 1 1 1 1 Metallothionein BMF PF15185.4 NM_001003940.1_2 - 9.4e-68 227.6 0.0 1.6e-67 226.9 0.0 1.3 1 0 0 1 1 1 1 Bcl-2-modifying factor, apoptosis LAT PF15234.4 NM_014387.3_2 - 4.3e-121 403.1 5.9 5.6e-121 402.7 5.9 1.1 1 0 0 1 1 1 1 Linker for activation of T-cells LAX PF15681.3 NM_014387.3_2 - 0.25 9.9 4.1 0.66 8.5 3.9 1.7 1 1 0 1 1 1 0 Lymphocyte activation family X DENN PF02141.19 NM_001308339.1_2 - 3.6e-61 206.2 3.3 6.8e-61 205.3 3.3 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain RUN PF02759.17 NM_001308339.1_2 - 9.2e-41 138.9 1.9 5.9e-20 71.5 1.9 2.6 2 0 0 2 2 2 2 RUN domain dDENN PF03455.17 NM_001308339.1_2 - 2.5e-18 65.6 1.7 2.5e-18 65.6 1.7 2.7 3 0 0 3 3 3 1 dDENN domain uDENN PF03456.16 NM_001308339.1_2 - 1.9e-14 54.1 0.1 5.3e-14 52.6 0.1 1.8 1 0 0 1 1 1 1 uDENN domain PLAT PF01477.21 NM_001308339.1_2 - 5.5e-10 39.7 0.0 1.3e-09 38.5 0.0 1.6 1 0 0 1 1 1 1 PLAT/LH2 domain DUF837 PF05769.9 NM_001171888.1_3 - 1.9e-54 184.2 15.3 2.5e-54 183.9 15.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF837) Tho2 PF11262.6 NM_001171888.1_3 - 0.0021 17.2 5.5 0.003 16.7 5.5 1.1 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Spc7 PF08317.9 NM_001171888.1_3 - 0.061 12.1 15.8 0.082 11.6 15.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein BST2 PF16716.3 NM_001171888.1_3 - 0.27 11.7 9.2 3.6 8.1 2.6 2.4 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Prefoldin_2 PF01920.18 NM_001171888.1_3 - 0.3 11.0 11.0 0.46 10.3 2.6 2.5 2 0 0 2 2 2 0 Prefoldin subunit FUSC PF04632.10 NM_001171888.1_3 - 0.35 9.2 5.9 0.44 8.9 5.9 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family PCRF PF03462.16 NM_001171888.1_3 - 0.39 10.4 8.9 0.93 9.2 8.9 1.6 1 1 0 1 1 1 0 PCRF domain DUF342 PF03961.11 NM_001171888.1_3 - 0.42 9.0 7.1 0.55 8.6 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Anthrax_toxA PF03497.14 NM_001171888.1_3 - 0.62 10.0 3.6 0.48 10.4 1.0 1.8 1 1 1 2 2 2 0 Anthrax toxin LF subunit CHD5 PF04420.12 NM_001171888.1_3 - 1.2 8.8 4.0 2.6 7.7 4.0 1.5 1 1 0 1 1 1 0 CHD5-like protein Atg14 PF10186.7 NM_001171888.1_3 - 2.3 7.1 10.1 3.1 6.7 10.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF16 PF01519.14 NM_001171888.1_3 - 2.4 8.6 9.4 1.2e+02 3.1 9.5 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 TolA_bind_tri PF16331.3 NM_001171888.1_3 - 3.9 7.5 16.6 61 3.7 16.6 2.3 1 1 0 1 1 1 0 TolA binding protein trimerisation Exonuc_VII_L PF02601.13 NM_001171888.1_3 - 4.3 6.7 8.6 5.6 6.3 8.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2570 PF10828.6 NM_001171888.1_3 - 4.5 7.1 14.0 3.9 7.3 3.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) Sec20 PF03908.11 NM_001171888.1_3 - 10 6.0 6.9 24 4.8 1.3 2.3 1 1 1 2 2 2 0 Sec20 zf-H2C2_2 PF13465.4 NM_001318082.1_1 - 4.8e-64 210.0 104.5 1.9e-09 37.4 1.5 15.9 15 0 0 15 15 15 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001318082.1_1 - 2.8e-49 162.8 119.2 3.9e-05 23.7 0.3 14.3 14 0 0 14 14 13 12 Zinc finger, C2H2 type SCAN PF02023.15 NM_001318082.1_1 - 1.4e-40 136.9 5.4 3.2e-40 135.7 5.4 1.7 1 0 0 1 1 1 1 SCAN domain zf-C2H2_4 PF13894.4 NM_001318082.1_1 - 4.1e-21 73.7 113.6 0.0056 17.3 0.2 14.8 14 0 0 14 14 14 12 C2H2-type zinc finger KRAB PF01352.25 NM_001318082.1_1 - 1.2e-13 50.3 0.0 3.2e-13 49.0 0.0 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001318082.1_1 - 5.4e-07 29.3 91.7 0.024 14.4 0.1 14.3 14 0 0 14 14 14 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001318082.1_1 - 0.00018 21.4 56.3 0.025 14.6 1.6 8.7 6 3 4 10 10 10 6 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001318082.1_1 - 0.0043 16.6 1.1 0.0043 16.6 1.1 11.0 12 0 0 12 12 12 3 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_001318082.1_1 - 0.055 14.1 47.7 3 8.5 1.8 7.6 3 3 4 8 8 8 0 zinc-ribbon family DUF3268 PF11672.6 NM_001318082.1_1 - 3.2 8.0 37.2 2.4 8.4 1.0 6.3 6 0 0 6 6 6 0 zinc-finger-containing domain ADK_lid PF05191.12 NM_001318082.1_1 - 6.6 6.7 40.8 0.31 11.0 1.2 8.2 6 1 3 9 9 9 0 Adenylate kinase, active site lid FYVE PF01363.19 NM_001318082.1_1 - 7.6 6.6 61.1 0.053 13.5 3.4 8.1 3 3 2 5 5 4 0 FYVE zinc finger Osteoregulin PF07175.9 NM_001184697.1_3 - 3.2e-88 293.8 6.3 3.2e-88 293.8 6.3 2.3 3 0 0 3 3 3 1 Osteoregulin Ribosomal_L15e PF00827.15 NM_001253382.1_1 - 8.1e-97 322.4 3.4 1e-96 322.0 3.4 1.1 1 0 0 1 1 1 1 Ribosomal L15 Tetraspannin PF00335.18 NM_001257390.1_3 - 1.3e-49 168.8 18.1 1.5e-49 168.5 18.1 1.1 1 0 0 1 1 1 1 Tetraspanin family Clc-like PF07062.10 NM_001257390.1_3 - 0.14 11.5 4.0 0.27 10.6 1.4 2.2 2 0 0 2 2 2 0 Clc-like SseC PF04888.10 NM_001257390.1_3 - 0.88 8.9 2.6 1.2 8.5 1.1 1.8 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family DUF2976 PF11190.6 NM_001257390.1_3 - 7.3 6.3 8.6 21 4.9 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) cNMP_binding PF00027.27 NM_001164761.1_2 - 9.7e-41 137.6 0.0 6.4e-20 70.8 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 NM_001164761.1_2 - 1.2e-13 50.3 0.0 2.1e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Peptidase_S8 PF00082.20 NM_001289824.1_3 - 1.1e-48 166.0 5.8 1.4e-48 165.6 5.8 1.1 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.18 NM_001289824.1_3 - 3.7e-28 97.3 0.0 6.3e-28 96.5 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.3 NM_001289824.1_3 - 4.1e-24 85.1 0.5 7.3e-24 84.3 0.5 1.4 1 0 0 1 1 1 1 Peptidase S8 pro-domain Furin-like_2 PF15913.3 NM_001289824.1_3 - 0.0077 16.2 1.4 0.0077 16.2 1.4 2.3 1 1 1 2 2 2 1 Furin-like repeat, cysteine-rich DUF357 PF04010.11 NM_001289824.1_3 - 0.098 12.6 0.3 0.18 11.8 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF357) VSP PF03302.11 NM_001289824.1_3 - 0.11 11.2 17.5 0.084 11.6 6.2 2.3 1 1 0 2 2 2 0 Giardia variant-specific surface protein Filament PF00038.19 NM_001927.3_3 - 3.2e-115 384.9 47.9 3.2e-115 384.9 47.9 1.4 2 0 0 2 2 1 1 Intermediate filament protein Filament_head PF04732.12 NM_001927.3_3 - 4.8e-24 84.9 7.9 1.3e-23 83.6 7.9 1.8 1 0 0 1 1 1 1 Intermediate filament head (DNA binding) region Reo_sigmaC PF04582.10 NM_001927.3_3 - 0.00095 18.5 5.6 0.36 10.1 0.4 2.9 1 1 2 3 3 3 2 Reovirus sigma C capsid protein Spc7 PF08317.9 NM_001927.3_3 - 0.0023 16.7 8.9 0.0023 16.7 8.9 3.1 1 1 2 3 3 3 2 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 NM_001927.3_3 - 0.031 14.4 39.7 0.64 10.1 8.6 4.0 1 1 1 3 3 3 0 JNK_SAPK-associated protein-1 Trimer_CC PF08954.9 NM_001927.3_3 - 0.058 12.8 0.2 0.058 12.8 0.2 4.1 3 0 0 3 3 3 0 Trimerisation motif DUF1664 PF07889.10 NM_001927.3_3 - 0.16 11.8 19.6 0.14 12.0 2.5 4.0 1 1 3 5 5 5 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 NM_001927.3_3 - 0.19 11.6 17.0 0.57 10.1 0.5 4.0 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Golgin_A5 PF09787.7 NM_001927.3_3 - 0.23 10.8 37.0 0.26 10.6 9.1 2.5 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF4407 PF14362.4 NM_001927.3_3 - 0.71 9.0 31.7 4.4 6.4 8.5 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) GAS PF13851.4 NM_001927.3_3 - 0.75 9.0 41.5 0.025 13.8 11.1 3.9 1 1 2 3 3 2 0 Growth-arrest specific micro-tubule binding Patched PF02460.16 NM_001927.3_3 - 1 7.2 4.2 1.4 6.7 4.2 1.1 1 0 0 1 1 1 0 Patched family CENP-H PF05837.10 NM_001927.3_3 - 1.1 9.5 33.0 0.19 12.0 3.2 4.4 1 1 2 4 4 4 0 Centromere protein H (CENP-H) TPR_MLP1_2 PF07926.10 NM_001927.3_3 - 1.5 8.8 41.9 1.5 8.7 10.0 3.7 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.6 NM_001927.3_3 - 1.9 5.7 39.1 4.4 4.5 38.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Prefoldin PF02996.15 NM_001927.3_3 - 2 8.2 25.5 0.042 13.6 1.9 5.1 4 1 0 4 4 4 0 Prefoldin subunit CENP-F_leu_zip PF10473.7 NM_001927.3_3 - 2.3 8.1 35.1 1.5 8.7 5.0 2.9 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HMMR_N PF15905.3 NM_001927.3_3 - 2.8 7.2 37.3 0.26 10.6 5.9 3.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF5082 PF16888.3 NM_001927.3_3 - 2.8 8.2 27.0 1.3 9.3 0.3 4.5 3 2 1 4 4 4 0 Domain of unknown function (DUF5082) IncA PF04156.12 NM_001927.3_3 - 3.4 7.3 45.0 3 7.5 2.2 3.8 1 1 4 5 5 5 0 IncA protein Mnd1 PF03962.13 NM_001927.3_3 - 3.7 7.2 34.3 1.6e+04 -10.9 34.1 3.6 1 1 0 1 1 0 0 Mnd1 family Lzipper-MIP1 PF14389.4 NM_001927.3_3 - 4 7.6 21.5 22 5.3 0.1 4.2 3 1 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 DUF573 PF04504.12 NM_001927.3_3 - 4.1 8.0 8.9 7.2 7.2 0.5 3.8 2 2 2 4 4 4 0 Protein of unknown function, DUF573 KASH_CCD PF14662.4 NM_001927.3_3 - 4.4 7.0 41.0 1.2 8.8 0.4 4.0 1 1 3 4 4 4 0 Coiled-coil region of CCDC155 or KASH HALZ PF02183.16 NM_001927.3_3 - 5.1 7.3 26.2 1.5 9.0 0.1 5.2 6 1 0 6 6 5 0 Homeobox associated leucine zipper APG6 PF04111.10 NM_001927.3_3 - 6.5 5.9 41.6 0.47 9.7 10.3 3.2 1 1 2 3 3 3 0 Autophagy protein Apg6 KLRAQ PF10205.7 NM_001927.3_3 - 6.7 6.9 26.9 2.5 8.3 11.0 3.9 2 2 3 5 5 5 0 Predicted coiled-coil domain-containing protein DUF4515 PF14988.4 NM_001927.3_3 - 7.5 6.2 39.8 0.44 10.3 9.1 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4515) Fib_alpha PF08702.8 NM_001927.3_3 - 9.8 6.2 27.5 0.55 10.3 7.0 3.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Glyco_transf_8 PF01501.18 NM_001010983.2_3 - 4.4e-64 216.4 0.0 5.4e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 Ank_2 PF12796.5 NM_001242813.1_3 - 1.6e-37 127.9 16.0 1e-09 38.7 0.3 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001242813.1_3 - 2.6e-34 117.0 10.5 3.7e-09 36.8 0.1 6.5 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001242813.1_3 - 1.4e-33 114.2 15.3 2.1e-10 40.5 0.1 5.2 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 NM_001242813.1_3 - 4.4e-32 109.0 25.1 1.9e-06 27.9 0.2 7.7 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.4 NM_001242813.1_3 - 1.8e-23 79.9 9.9 8.1e-05 22.6 0.1 8.2 8 0 0 8 8 7 5 Ankyrin repeat DUF445 PF04286.10 NM_001242813.1_3 - 0.042 13.5 0.1 0.042 13.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF445) CLZ PF16526.3 NM_001242813.1_3 - 0.061 13.5 7.7 2.7 8.3 3.0 2.7 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Phasin PF05597.9 NM_001242813.1_3 - 0.071 13.0 7.5 0.66 9.9 2.0 2.5 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Apolipoprotein PF01442.16 NM_001242813.1_3 - 0.51 10.1 15.9 0.23 11.2 2.7 2.4 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.9 NM_001242813.1_3 - 7 6.6 10.2 8.4 6.3 3.6 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Swi5 PF07061.9 NM_001242813.1_3 - 8.1 6.4 8.0 1.4 8.9 1.4 2.4 2 0 0 2 2 2 0 Swi5 INSIG PF07281.10 NM_001321330.1_1 - 4.4e-36 124.4 2.6 1.5e-35 122.6 2.6 1.8 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) EURL PF06937.9 NM_017447.3_2 - 1.4e-167 556.1 10.0 1.7e-167 555.8 10.0 1.1 1 0 0 1 1 1 1 EURL protein zf-DHHC PF01529.18 NM_144969.2_2 - 1.2e-33 115.9 20.9 1.2e-33 115.9 20.9 2.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase WW PF00397.24 NM_001270455.1_1 - 1.8e-12 46.8 2.0 1.8e-12 46.8 2.0 2.3 2 0 0 2 2 2 1 WW domain muHD PF10291.7 NM_001161359.1_3 - 9e-55 185.8 0.0 1.2e-54 185.3 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.21 NM_001161359.1_3 - 8e-15 54.7 1.0 2.1e-14 53.4 0.0 2.3 3 1 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain U1snRNP70_N PF12220.6 NM_001161359.1_3 - 0.00097 19.6 4.9 0.017 15.6 2.3 2.6 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SAPIS-gp6 PF16722.3 NM_001161359.1_3 - 0.042 14.1 0.2 0.15 12.3 0.0 2.0 2 0 0 2 2 2 0 Pathogenicity island protein gp6 in Staphylococcus Phospholip_A2_1 PF00068.17 NM_000929.2_2 - 8.8e-34 116.1 7.0 1.2e-33 115.7 7.0 1.2 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.10 NM_000929.2_2 - 0.21 11.6 10.2 1.6 8.8 10.2 2.1 1 1 0 1 1 1 0 Phospholipase A2 zf-DHHC PF01529.18 NM_207340.1_3 - 4.9e-26 91.3 0.8 7.7e-26 90.7 0.8 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase DEAD PF00270.27 NM_001356.4_1 - 3.2e-50 170.2 0.0 6.7e-50 169.1 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001356.4_1 - 8e-31 106.6 0.0 1.4e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_001356.4_1 - 0.0032 17.4 0.0 0.0054 16.6 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.10 NM_001356.4_1 - 0.056 12.1 0.0 0.096 11.3 0.0 1.2 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Adhesin_P1 PF03257.11 NM_001356.4_2 - 0.16 12.4 0.1 0.31 11.5 0.1 1.3 1 0 0 1 1 1 0 Mycoplasma adhesin P1 zf-SCNM1 PF15803.3 NM_001172357.1_2 - 0.0038 16.7 1.0 0.011 15.2 1.0 1.8 1 0 0 1 1 1 1 Zinc-finger of sodium channel modifier 1 SP_C-Propep PF08999.8 NM_001172357.1_3 - 1.1e-52 175.7 3.0 1.5e-52 175.2 3.0 1.2 1 0 0 1 1 1 1 Surfactant protein C, N terminal propeptide BRICHOS PF04089.12 NM_001172357.1_3 - 4.9e-20 71.3 0.0 7e-20 70.8 0.0 1.2 1 0 0 1 1 1 1 BRICHOS domain FtsX PF02687.19 NM_001172357.1_3 - 0.02 14.7 2.0 0.032 14.1 2.0 1.2 1 0 0 1 1 1 0 FtsX-like permease family Transglut_core PF01841.17 NM_178554.4_3 - 3.4e-15 56.3 0.1 5.8e-15 55.6 0.1 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Ank_5 PF13857.4 NM_001172735.2_1 - 1.8e-16 59.8 4.4 2.8e-11 43.3 1.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_001172735.2_1 - 1.9e-16 60.2 0.9 4.1e-16 59.2 0.9 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 NM_001172735.2_1 - 1.2e-15 57.0 10.2 7e-08 32.5 0.3 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.4 NM_001172735.2_1 - 7.6e-15 54.9 0.9 5e-08 33.2 0.1 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001172735.2_1 - 6.6e-11 41.3 1.6 0.0003 20.9 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat PID PF00640.21 NM_001257326.2_3 - 7.5e-47 158.7 0.0 1.5e-38 131.8 0.0 2.3 2 1 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.24 NM_001257326.2_3 - 7.2e-06 25.7 3.0 7.2e-06 25.7 3.0 2.0 2 0 0 2 2 2 1 WW domain PTB PF08416.11 NM_001257326.2_3 - 1e-05 25.5 0.0 0.0001 22.3 0.0 2.1 2 0 0 2 2 2 1 Phosphotyrosine-binding domain PID_2 PF14719.4 NM_001257326.2_3 - 0.022 14.5 0.0 6.3 6.5 0.0 2.2 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) 7tm_4 PF13853.4 NM_001001658.1_1 - 7.6e-34 117.6 15.8 9.5e-34 117.3 15.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001001658.1_1 - 7.1e-20 71.2 23.0 1.4e-19 70.2 23.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001001658.1_1 - 0.056 12.7 23.8 0.2 10.9 23.8 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx PMP22_Claudin PF00822.18 NM_006539.3_3 - 8.1e-50 168.8 0.4 1.3e-49 168.1 0.4 1.4 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_006539.3_3 - 3e-19 69.4 0.7 5e-19 68.7 0.7 1.4 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction zf-H2C2_2 PF13465.4 NM_001143767.1_3 - 1.5e-07 31.4 24.1 0.00012 22.2 4.0 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001143767.1_3 - 0.0004 20.8 43.5 0.00042 20.8 2.3 5.7 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001143767.1_3 - 0.0015 18.7 2.8 0.0015 18.7 2.8 4.8 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-met PF12874.5 NM_001143767.1_3 - 0.073 13.4 0.1 0.073 13.4 0.1 3.7 4 0 0 4 4 4 0 Zinc-finger of C2H2 type 7tm_1 PF00001.19 NM_001303473.1_3 - 1e-12 47.7 3.4 1.7e-12 47.0 3.4 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rab5ip PF07019.10 NM_001303473.1_3 - 0.078 13.5 2.1 0.11 13.0 0.2 2.2 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) UCH PF00443.27 NM_003940.2_1 - 9.1e-48 162.9 0.0 1.2e-47 162.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.29 NM_003940.2_1 - 6.1e-24 83.4 0.4 4.6e-13 48.7 0.1 2.5 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP PF02148.17 NM_003940.2_1 - 6.9e-14 51.8 1.7 6.2e-13 48.7 0.0 3.2 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 NM_003940.2_1 - 1.1e-10 41.6 0.0 4.1e-10 39.7 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.4 NM_003940.2_1 - 0.0068 16.1 0.1 0.013 15.2 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain UBA_3 PF09288.8 NM_003940.2_1 - 0.19 11.4 0.0 0.99 9.1 0.0 2.0 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain Tis11B_N PF04553.10 NM_004926.3_2 - 1.4e-29 102.9 0.0 3e-29 101.8 0.0 1.6 1 0 0 1 1 1 1 Tis11B like protein, N terminus zf-CCCH PF00642.22 NM_004926.3_2 - 1.6e-21 75.6 14.8 4.6e-11 42.2 2.0 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 NM_004926.3_2 - 0.014 15.7 14.6 0.32 11.4 1.4 2.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Torus PF16131.3 NM_004926.3_2 - 0.033 14.7 8.6 1.6 9.3 1.1 2.4 1 1 1 2 2 2 0 Torus domain Nucleoside_tran PF01733.16 NM_001078177.1_3 - 2.6e-131 437.5 7.4 2.6e-131 437.5 7.4 1.7 1 1 1 2 2 2 1 Nucleoside transporter Guanylate_cyc_2 PF09778.7 NM_001284254.1_2 - 6e-89 296.8 0.9 7.6e-89 296.4 0.9 1.1 1 0 0 1 1 1 1 Guanylylate cyclase Peptidase_C39_2 PF13529.4 NM_001284254.1_2 - 6.7e-06 26.6 0.0 2.1e-05 25.0 0.0 1.8 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.6 NM_001284254.1_2 - 2.4e-05 24.2 0.0 0.26 11.1 0.0 2.3 2 0 0 2 2 2 2 Papain-like cysteine protease AvrRpt2 DUF3335 PF11814.6 NM_001284254.1_2 - 0.0054 16.1 0.1 0.16 11.3 0.0 2.1 2 0 0 2 2 2 1 Peptidase_C39 like family Peptidase_C39 PF03412.13 NM_001284254.1_2 - 0.027 14.1 0.0 0.2 11.4 0.0 2.1 2 0 0 2 2 2 0 Peptidase C39 family FXa_inhibition PF14670.4 NM_001284254.1_2 - 5.2 7.3 14.1 16 5.7 1.3 3.2 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site ACBP PF00887.17 NM_001178017.1_1 - 7.1e-32 109.4 0.9 9.7e-32 108.9 0.9 1.2 1 0 0 1 1 1 1 Acyl CoA binding protein S1 PF00575.21 NM_001282566.1_2 - 5.4e-08 32.9 0.0 1.1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain SR-25 PF10500.7 NM_001282566.1_2 - 0.0022 17.5 24.9 0.0037 16.8 24.9 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein zf-CCHC PF00098.21 NM_001282566.1_2 - 0.016 15.1 5.9 0.039 13.9 5.9 1.6 1 0 0 1 1 1 0 Zinc knuckle Coilin_N PF15862.3 NM_001282566.1_2 - 0.027 14.1 13.9 4.3 7.0 13.9 2.5 1 1 0 1 1 1 0 Coilin N-terminus PCB_OB PF17092.3 NM_001282566.1_2 - 0.3 11.7 0.1 0.3 11.7 0.1 1.8 2 0 0 2 2 2 0 Penicillin-binding protein OB-like domain DUF3827 PF12877.5 NM_001282566.1_2 - 0.4 8.9 11.9 0.52 8.5 11.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Zip PF02535.20 NM_001282566.1_2 - 1.7 7.6 4.9 2.3 7.2 4.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.12 NM_001282566.1_2 - 2 6.5 18.8 2.9 6.0 18.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Pap_E4 PF02711.12 NM_001282566.1_2 - 3.9 8.4 11.1 10 7.1 11.1 1.7 1 0 0 1 1 1 0 E4 protein Menin PF05053.11 NM_001282566.1_2 - 6.9 4.8 7.9 8.9 4.4 7.9 1.1 1 0 0 1 1 1 0 Menin Arf PF00025.19 NM_033228.2_3 - 8.4e-61 204.3 0.9 1.3e-60 203.7 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.11 NM_033228.2_3 - 1.5e-13 50.9 0.2 1.7e-12 47.5 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_033228.2_3 - 1e-11 44.6 0.0 1.9e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 NM_033228.2_3 - 9.9e-11 41.3 0.0 1.8e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 NM_033228.2_3 - 9e-10 38.1 0.1 1.8e-07 30.5 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit zf-B_box PF00643.22 NM_033228.2_3 - 6.7e-07 29.2 5.9 6.7e-07 29.2 5.9 4.1 4 0 0 4 4 3 2 B-box zinc finger zf-RING_5 PF14634.4 NM_033228.2_3 - 2.3e-06 27.3 1.9 2.3e-06 27.3 1.9 4.2 3 1 0 3 3 2 1 zinc-RING finger domain Gtr1_RagA PF04670.10 NM_033228.2_3 - 2.3e-06 27.0 0.0 4.8e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region zf-RING_UBOX PF13445.4 NM_033228.2_3 - 3.6e-06 26.7 5.4 3.6e-06 26.7 5.4 2.7 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_033228.2_3 - 3.2e-05 23.9 3.4 3.2e-05 23.9 3.4 4.1 4 0 0 4 4 3 1 Ring finger domain MMR_HSR1 PF01926.21 NM_033228.2_3 - 0.00068 19.6 0.1 0.0018 18.2 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase zf-C3HC4 PF00097.23 NM_033228.2_3 - 0.0019 17.9 1.7 0.0019 17.9 1.7 3.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_033228.2_3 - 0.007 16.1 2.8 0.007 16.1 2.8 3.1 4 0 0 4 4 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.4 NM_033228.2_3 - 0.011 15.5 3.7 0.011 15.5 3.7 3.2 3 0 0 3 3 2 0 Zinc finger, C3HC4 type (RING finger) Trypsin PF00089.24 NM_024022.2_1 - 6e-68 228.8 0.0 8.2e-68 228.4 0.0 1.2 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.4 NM_024022.2_1 - 8.5e-24 83.8 0.4 1.4e-23 83.1 0.4 1.3 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF1986 PF09342.9 NM_024022.2_1 - 4e-07 30.3 0.0 8.4e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SRCR PF00530.16 NM_024022.2_1 - 1e-06 29.0 0.1 2.1e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Ldl_recept_a PF00057.16 NM_024022.2_1 - 6e-06 26.2 10.3 1.5e-05 25.0 10.3 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Trypsin_2 PF13365.4 NM_024022.2_1 - 0.006 17.3 0.0 0.014 16.1 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Hepsin-SRCR PF09272.8 NM_024022.2_1 - 0.016 15.4 0.4 0.033 14.4 0.4 1.4 1 0 0 1 1 1 0 Hepsin, SRCR COMM_domain PF07258.12 NM_001287394.1_1 - 2.1e-16 59.6 0.0 3.2e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 COMM domain RabGAP-TBC PF00566.16 NM_001001418.6_3 - 1.1e-37 129.6 0.0 1.5e-37 129.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain HLH PF00010.24 NM_001243231.1_2 - 2.4e-11 43.3 1.0 5.6e-11 42.1 1.0 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 NM_001243231.1_2 - 4.6 5.3 6.7 6.8 4.7 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SET PF00856.26 NM_001300907.1_2 - 1.1e-11 45.3 1.9 3.2e-11 43.8 0.1 2.4 2 0 0 2 2 2 1 SET domain FH2 PF02181.21 NM_198900.2_1 - 1e-106 357.1 5.9 1e-106 357.1 5.9 2.9 3 0 0 3 3 3 1 Formin Homology 2 Domain Drf_FH3 PF06367.14 NM_198900.2_1 - 1.1e-49 168.6 13.3 1.6e-49 168.0 13.3 1.3 1 0 0 1 1 1 1 Diaphanous FH3 Domain Drf_GBD PF06371.11 NM_198900.2_1 - 4.1e-30 104.6 0.1 4.1e-30 104.6 0.1 2.7 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain COG2 PF06148.9 NM_198900.2_1 - 0.021 14.8 7.3 0.02 14.8 5.4 1.9 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 zf-H2C2_2 PF13465.4 NM_145276.2_1 - 0.00021 21.5 1.2 0.00021 21.5 1.2 5.4 5 1 0 5 5 5 1 Zinc-finger double domain zf-C2H2 PF00096.24 NM_145276.2_1 - 0.0014 18.9 23.7 0.17 12.3 1.4 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_145276.2_1 - 0.0098 15.7 5.1 0.0098 15.7 5.1 4.4 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_4 PF13894.4 NM_145276.2_1 - 0.043 14.5 28.0 0.18 12.6 3.7 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_145276.2_2 - 9.8e-72 234.3 114.8 3e-08 33.6 1.5 15.1 15 0 0 15 15 14 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_145276.2_2 - 1.7e-38 128.8 110.7 1.3e-05 25.3 0.4 13.7 14 0 0 14 14 14 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_145276.2_2 - 2.7e-31 105.4 101.1 0.00021 21.7 0.3 13.6 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_145276.2_2 - 4.3e-20 71.0 0.1 7.7e-20 70.2 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_145276.2_2 - 1.3e-13 50.7 50.1 0.015 15.5 0.1 11.8 11 0 0 11 11 11 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_145276.2_2 - 2.5e-10 39.9 91.2 0.0006 19.6 0.5 13.9 14 2 0 14 14 14 9 C2H2-type zinc finger C1_1 PF00130.20 NM_145276.2_2 - 7.2e-08 32.1 39.0 0.028 14.1 0.6 9.1 3 2 5 9 9 9 7 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.8 NM_145276.2_2 - 1.4e-07 31.4 57.1 0.048 13.7 1.8 10.0 6 2 5 11 11 11 7 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_145276.2_2 - 0.00034 20.2 4.9 0.0036 16.9 0.4 9.5 12 0 0 12 12 12 4 zinc-finger C2H2-type Yippee-Mis18 PF03226.12 NM_145276.2_2 - 0.007 16.4 1.9 0.007 16.4 1.9 3.9 4 1 1 5 5 4 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_15 PF17032.3 NM_145276.2_2 - 0.0083 16.7 42.2 0.21 12.2 2.5 6.4 4 2 2 6 6 5 4 zinc-ribbon family DZR PF12773.5 NM_145276.2_2 - 0.074 13.0 47.7 2.5e+03 -1.5 0.1 6.7 2 1 0 2 2 1 0 Double zinc ribbon zf-trcl PF13451.4 NM_145276.2_2 - 1.7 8.5 54.0 6.8 6.5 0.2 9.9 9 3 0 9 9 9 0 Probable zinc-ribbon domain GAGA PF09237.9 NM_145276.2_2 - 2.1 8.1 18.1 7.5 6.3 0.4 5.6 6 0 0 6 6 6 0 GAGA factor DNA_ligase_A_M PF01068.19 NM_001289063.1_1 - 2e-68 230.0 0.2 3e-68 229.4 0.2 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 NM_001289063.1_1 - 1.1e-37 129.9 0.0 1.9e-37 129.1 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.13 NM_001289063.1_1 - 2.5e-24 85.6 0.0 1.2e-23 83.4 0.0 2.3 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.4 NM_001289063.1_1 - 0.0076 16.1 0.3 2.1 8.3 0.0 2.7 2 0 0 2 2 2 2 DNA ligase OB-like domain Presenilin PF01080.15 NM_001289063.1_1 - 0.088 11.4 1.0 0.14 10.7 1.0 1.2 1 0 0 1 1 1 0 Presenilin Caveolin PF01146.15 NM_001206747.1_2 - 4.6e-56 188.3 1.1 7.7e-56 187.6 1.1 1.3 1 0 0 1 1 1 1 Caveolin DUF2152 PF10222.7 NM_138346.2_3 - 4e-252 837.8 0.0 4.6e-252 837.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2152) Xin PF08043.10 NM_001198621.2_1 - 2.1e-84 274.8 57.3 1.2e-08 34.2 0.2 15.9 16 0 0 16 16 16 15 Xin repeat DUF4548 PF15081.4 NM_139240.3_1 - 1e-99 331.1 3.1 1.3e-99 330.8 3.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4548) GTP_EFTU PF00009.25 NM_001130007.1_3 - 1.2e-45 155.4 0.0 1.8e-45 154.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 NM_001130007.1_3 - 1.2e-30 105.9 0.4 5e-30 103.9 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 NM_001130007.1_3 - 2.3e-07 31.0 0.1 3.9e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 NM_001130007.1_3 - 0.014 15.3 0.0 0.03 14.3 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Pyridoxal_deC PF00282.17 NM_001244706.1_2 - 1.3e-65 221.4 0.1 1.7e-65 221.0 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 NM_001244706.1_2 - 0.0016 17.3 0.0 0.0026 16.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V HMG_box PF00505.17 NM_145205.5_1 - 1.4e-31 108.6 9.6 2.2e-17 63.1 0.1 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_145205.5_1 - 5e-28 97.4 9.5 4.8e-18 65.4 5.2 2.4 2 0 0 2 2 2 2 HMG-box domain DUF1014 PF06244.10 NM_145205.5_1 - 0.016 15.7 2.4 0.027 14.9 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1014) Fascin PF06268.11 NM_012418.3_1 - 4.8e-122 400.1 0.0 8.3e-34 116.0 0.0 4.1 4 0 0 4 4 4 4 Fascin domain FRG1 PF06229.10 NM_012418.3_1 - 1.3e-16 60.8 0.0 6.5e-05 22.6 0.0 6.3 3 2 3 6 6 6 6 FRG1-like domain FGF PF00167.16 NM_012418.3_1 - 3.2e-08 33.6 0.0 0.00018 21.5 0.0 2.9 3 0 0 3 3 3 2 Fibroblast growth factor DUF569 PF04601.11 NM_012418.3_1 - 0.0022 17.5 0.0 0.22 11.1 0.0 3.4 4 1 0 4 4 4 1 Domain of unknown function (DUF569) zf-H2C2_2 PF13465.4 NM_001286769.1_1 - 3.3e-86 280.0 94.9 1.5e-08 34.6 0.7 14.7 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001286769.1_1 - 1.1e-63 208.1 108.2 1.1e-06 28.6 1.3 13.2 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001286769.1_1 - 1.6e-34 115.4 97.1 0.0092 16.6 0.6 12.8 12 0 0 12 12 12 12 C2H2-type zinc finger KRAB PF01352.25 NM_001286769.1_1 - 3.4e-23 80.9 0.0 6e-23 80.1 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001286769.1_1 - 3.6e-19 68.1 81.0 0.0031 17.3 0.1 12.8 12 0 0 12 12 12 12 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001286769.1_1 - 2.5e-12 46.6 53.1 0.0029 17.5 1.9 8.2 5 4 4 9 9 9 8 Zinc ribbon domain XPA_N PF01286.16 NM_001286769.1_1 - 5e-09 35.9 53.4 1.2 9.1 0.1 12.1 12 0 0 12 12 12 6 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001286769.1_1 - 1.7e-06 28.6 50.4 0.21 12.2 3.3 7.1 1 1 6 8 8 8 7 zinc-ribbon family DZR PF12773.5 NM_001286769.1_1 - 2.6e-06 27.2 49.5 0.021 14.7 7.9 6.6 3 2 3 6 6 6 4 Double zinc ribbon FAM178 PF14816.4 NM_001286769.1_1 - 0.018 13.9 5.7 5.2 5.8 0.5 4.2 1 1 3 5 5 5 0 Family of unknown function, FAM178 MRP-S23 PF10484.7 NM_001286769.1_1 - 0.076 13.1 0.0 59 3.8 0.0 4.2 4 1 0 4 4 4 0 Mitochondrial ribosomal protein S23 zf-C2H2_11 PF16622.3 NM_001286769.1_1 - 0.72 9.5 58.8 0.34 10.6 0.1 10.3 11 0 0 11 11 11 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 NM_001286769.1_1 - 1.6 9.0 65.8 1 9.6 0.9 12.0 12 0 0 12 12 12 0 Zinc-finger double-stranded RNA-binding ADK_lid PF05191.12 NM_001286769.1_1 - 4.3 7.3 47.0 1.1 9.2 1.7 8.1 6 2 2 8 8 8 0 Adenylate kinase, active site lid zf-AN1 PF01428.14 NM_001286769.1_1 - 4.9 7.3 59.6 31 4.7 0.6 12.1 10 2 2 12 12 12 0 AN1-like Zinc finger Pkinase PF00069.23 NM_001261435.1_3 - 6.9e-67 225.5 0.0 8.7e-67 225.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001261435.1_3 - 3.2e-32 111.7 0.0 4.6e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001261435.1_3 - 0.0056 15.9 0.0 0.0095 15.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like NHR2 PF08788.9 NM_005093.3_1 - 1.2e-37 127.4 9.9 2.2e-37 126.5 9.9 1.4 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 NM_005093.3_1 - 6.1e-34 115.8 2.2 6.1e-34 115.8 2.2 2.0 2 0 0 2 2 2 1 NHR1 homology to TAF zf-MYND PF01753.16 NM_005093.3_1 - 1.6e-06 28.0 15.7 1.6e-06 28.0 15.7 2.6 2 0 0 2 2 2 1 MYND finger Remorin_C PF03763.11 NM_005093.3_1 - 1 9.2 8.7 2.1 8.2 8.7 1.4 1 0 0 1 1 1 0 Remorin, C-terminal region Y_phosphatase PF00102.25 NM_030670.2_3 - 1.4e-83 279.9 2.0 2e-83 279.4 2.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.19 NM_030670.2_3 - 4.9e-07 29.9 0.1 1.2e-06 28.7 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Y_phosphatase3 PF13350.4 NM_030670.2_3 - 7.6e-05 22.6 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 NM_030670.2_3 - 0.00019 21.1 0.0 0.00037 20.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 NM_030670.2_3 - 0.001 19.1 0.1 0.0025 17.9 0.1 1.7 1 1 0 1 1 1 1 Inositol hexakisphosphate SIR2 PF02146.15 NM_012239.5_2 - 6.3e-54 182.4 0.0 8.2e-54 182.1 0.0 1.1 1 0 0 1 1 1 1 Sir2 family LNS2 PF08235.11 NM_145693.2_2 - 9.6e-104 345.6 0.0 1.6e-103 344.9 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 NM_145693.2_2 - 7.3e-45 151.0 0.0 1.3e-44 150.2 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 NM_145693.2_2 - 1.4e-32 111.8 0.0 2.7e-32 110.9 0.0 1.5 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.4 NM_145693.2_2 - 0.025 15.3 1.6 0.067 13.9 1.6 1.8 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Cadherin PF00028.15 NM_001142773.1_3 - 6.2e-121 395.0 21.2 3.2e-16 59.4 0.1 11.0 11 0 0 11 11 11 10 Cadherin domain Cadherin_3 PF16184.3 NM_001142773.1_3 - 1.2e-06 28.4 7.2 1.2 9.0 0.0 6.9 8 0 0 8 8 8 3 Cadherin-like Cadherin_2 PF08266.10 NM_001142773.1_3 - 4.1e-06 26.4 0.1 2.3 8.0 0.0 5.0 6 0 0 6 6 6 3 Cadherin-like Cadherin_pro PF08758.9 NM_001142773.1_3 - 0.02 14.9 0.0 65 3.7 0.0 4.5 5 0 0 5 5 5 0 Cadherin prodomain like zf-H2C2_2 PF13465.4 NM_001242799.1_3 - 5.1e-53 175.1 89.7 1.5e-07 31.4 1.1 14.7 14 1 0 14 14 14 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001242799.1_3 - 2.2e-36 122.2 91.3 2.2e-05 24.5 1.0 13.6 13 0 0 13 13 13 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001242799.1_3 - 2e-16 59.1 88.2 0.0058 17.2 0.2 13.4 13 0 0 13 13 13 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001242799.1_3 - 0.0036 17.1 1.0 0.0036 17.1 1.0 10.9 11 0 0 11 11 11 6 C2H2-type zinc finger C1_4 PF07975.10 NM_001242799.1_3 - 0.36 11.0 63.9 1.7 8.9 4.1 8.8 4 1 3 9 9 9 0 TFIIH C1-like domain BolA PF01722.16 NM_001242799.1_3 - 1.1 9.4 9.6 3.3 7.9 0.2 4.2 4 1 0 4 4 4 0 BolA-like protein Ta0938 PF11494.6 NM_001242799.1_3 - 1.7 8.8 4.8 0.86 9.8 0.1 2.8 3 0 0 3 3 3 0 Ta0938 Sushi PF00084.18 NM_030787.3_3 - 1.2e-61 205.1 61.7 2.4e-10 40.7 1.1 9.2 9 0 0 9 9 9 9 Sushi repeat (SCR repeat) UQ_con PF00179.24 NM_001282575.2_2 - 4.6e-10 39.2 0.1 7e-10 38.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SAA PF00277.16 NM_000331.5_2 - 6.5e-51 171.0 4.5 7e-51 170.8 2.9 1.7 2 0 0 2 2 2 1 Serum amyloid A protein Kelch_1 PF01344.23 NM_001199290.1_1 - 1.3e-49 165.4 22.4 9.2e-11 41.0 0.2 7.2 6 1 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 NM_001199290.1_1 - 3.3e-34 115.9 9.7 8.2e-08 32.1 0.1 6.6 3 2 3 6 6 6 6 Kelch motif BTB PF00651.29 NM_001199290.1_1 - 2.8e-28 98.2 0.8 4.2e-28 97.6 0.8 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 NM_001199290.1_1 - 1e-24 86.4 0.6 1e-24 86.4 0.6 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_4 PF13418.4 NM_001199290.1_1 - 1.2e-20 73.1 1.3 0.00055 19.7 0.0 6.6 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_001199290.1_1 - 1.8e-16 59.2 19.6 0.0023 17.7 0.1 7.4 7 1 0 7 7 7 6 Kelch motif Kelch_3 PF13415.4 NM_001199290.1_1 - 6e-14 51.8 9.7 0.00047 20.2 0.1 5.8 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_001199290.1_1 - 3.5e-08 33.1 15.9 0.024 14.5 0.2 6.6 6 0 0 6 6 6 3 Kelch motif DUF3342 PF11822.6 NM_001199290.1_1 - 0.0014 18.6 0.3 0.0044 17.0 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) Collagen PF01391.16 NM_001853.3_1 - 2.8e-92 302.3 353.8 2.5e-09 36.6 23.5 12.2 3 3 9 12 12 12 12 Collagen triple helix repeat (20 copies) UQ_con PF00179.24 NM_001278306.1_2 - 4.3e-29 100.8 0.0 6.5e-29 100.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DPM3 PF08285.9 NM_153741.1_3 - 2.6e-30 104.3 0.0 3.2e-30 104.0 0.0 1.1 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Beach PF02138.16 NM_020945.1_3 - 6.1e-120 399.6 0.0 9.1e-120 399.1 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.30 NM_020945.1_3 - 1.5e-07 31.9 12.4 0.0011 19.6 0.1 5.7 5 0 0 5 5 5 2 WD domain, G-beta repeat PH_BEACH PF14844.4 NM_020945.1_3 - 2.3e-06 27.5 0.4 6e-06 26.2 0.4 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4704 PF15787.3 NM_020945.1_3 - 4e-05 22.8 0.6 4e-05 22.8 0.6 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4704) Cadherin PF00028.15 NM_001317224.1_1 - 1.8e-79 262.2 5.3 1.4e-19 70.2 0.1 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 NM_001317224.1_1 - 3.7e-54 182.5 0.1 7.2e-54 181.5 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 NM_001317224.1_1 - 6.9e-07 29.1 6.4 0.0023 17.8 0.2 5.2 6 0 0 6 6 6 2 Cadherin-like Cadherin_2 PF08266.10 NM_001317224.1_1 - 0.00027 20.6 0.0 2.1 8.1 0.0 4.1 4 1 0 4 4 4 2 Cadherin-like Cadherin_pro PF08758.9 NM_001317224.1_1 - 0.13 12.3 0.0 4.6 7.3 0.0 3.0 3 0 0 3 3 3 0 Cadherin prodomain like OTU PF02338.17 NM_018566.3_3 - 8.9e-05 22.9 0.0 0.00017 22.0 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease PK PF00224.19 NM_002654.5_1 - 9.5e-172 570.5 1.8 1.2e-171 570.2 1.8 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 NM_002654.5_1 - 2e-34 118.2 0.0 4.5e-34 117.0 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 NM_002654.5_1 - 0.0034 16.4 0.1 0.0069 15.4 0.1 1.5 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family WD40 PF00400.30 NM_001280545.1_3 - 9.7e-08 32.4 12.1 0.86 10.5 0.1 6.9 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001280545.1_3 - 2.9e-07 30.6 0.1 0.15 12.2 0.0 4.2 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.12 NM_001280545.1_3 - 7.1e-05 21.9 6.3 0.054 12.4 0.0 4.9 5 1 0 5 5 5 2 Coatomer WD associated region TPR_7 PF13176.4 NM_001280545.1_3 - 0.0012 18.6 5.2 0.043 13.7 0.1 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat Clathrin PF00637.18 NM_001280545.1_3 - 0.0046 16.7 0.7 0.52 10.0 0.1 3.4 1 1 2 3 3 3 1 Region in Clathrin and VPS PHTB1_N PF14727.4 NM_001280545.1_3 - 0.011 15.0 0.1 0.02 14.1 0.1 1.3 1 0 0 1 1 1 0 PTHB1 N-terminus TPR_12 PF13424.4 NM_001280545.1_3 - 0.028 14.6 1.4 6.5 7.0 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat CENP-B_dimeris PF09026.8 NM_001280545.1_3 - 0.18 12.0 1.6 0.38 11.0 1.6 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Vps39_1 PF10366.7 NM_001280545.1_3 - 0.24 11.6 1.8 47 4.2 0.1 3.9 4 1 1 5 5 5 0 Vacuolar sorting protein 39 domain 1 TPR_14 PF13428.4 NM_001280545.1_3 - 0.32 11.8 1.7 1.2e+02 3.8 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001280545.1_3 - 1.5 9.0 15.2 8.6 6.6 0.1 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat ELL PF10390.7 NM_012081.5_3 - 9.5e-110 366.3 0.4 9.5e-110 366.3 0.4 2.1 2 0 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.11 NM_012081.5_3 - 8.8e-33 112.9 10.7 8.8e-33 112.9 10.7 2.0 2 0 0 2 2 2 1 Occludin homology domain TPR_1 PF00515.26 NM_172218.2_3 - 6.5e-43 142.7 26.6 1e-06 28.2 1.8 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.15 NM_172218.2_3 - 1.2e-35 118.6 19.5 5.6e-05 22.8 0.8 9.5 8 1 1 9 9 9 9 Tetratricopeptide repeat RPAP3_C PF13877.4 NM_172218.2_3 - 1.8e-17 63.5 0.2 4.8e-17 62.2 0.2 1.8 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_8 PF13181.4 NM_172218.2_3 - 1.5e-16 59.0 23.0 0.046 13.8 0.0 9.5 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_9 PF13371.4 NM_172218.2_3 - 1.4e-13 50.7 2.1 0.00013 22.0 0.0 4.6 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_172218.2_3 - 2.8e-12 46.8 10.5 0.001 19.4 0.0 5.3 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_172218.2_3 - 1.1e-09 38.4 20.7 0.021 15.0 1.6 7.7 4 3 3 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.4 NM_172218.2_3 - 8.4e-09 35.4 5.0 0.59 11.0 0.0 7.5 4 3 4 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_172218.2_3 - 2.7e-08 33.5 16.7 0.0006 19.9 0.0 6.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.4 NM_172218.2_3 - 3.9e-06 27.3 1.3 3.1 8.4 0.0 4.8 3 1 1 4 4 4 2 Tetratricopeptide repeat MIT PF04212.16 NM_172218.2_3 - 5.9e-06 26.1 7.9 0.5 10.4 0.1 4.9 4 0 0 4 4 4 3 MIT (microtubule interacting and transport) domain TPR_11 PF13414.4 NM_172218.2_3 - 7.1e-06 25.5 21.1 0.35 10.5 0.4 7.6 6 1 1 7 7 7 2 TPR repeat Fis1_TPR_C PF14853.4 NM_172218.2_3 - 1.2e-05 25.1 8.0 0.48 10.4 0.0 5.7 2 2 3 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat Rota_NSP3 PF01665.14 NM_172218.2_3 - 0.00046 19.3 0.8 0.001 18.1 0.8 1.5 1 0 0 1 1 1 1 Rotavirus non-structural protein NSP3 TPR_6 PF13174.4 NM_172218.2_3 - 0.0014 19.0 13.8 6.7 7.5 0.0 7.8 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_7 PF13176.4 NM_172218.2_3 - 0.014 15.3 13.2 3.7 7.7 0.0 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_15 PF13429.4 NM_172218.2_3 - 0.11 11.6 2.1 5.3 6.0 0.1 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.4 NM_172218.2_3 - 0.4 10.9 5.0 0.16 12.2 0.6 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_172218.2_3 - 0.57 10.0 13.4 8 6.4 0.1 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF3597 PF12200.6 NM_172218.2_3 - 3.2 8.2 6.3 3.4 8.1 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3597) PARP PF00644.18 NM_001323522.1_1 - 9.8e-13 48.1 0.2 1.8e-12 47.2 0.2 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF3513 PF12026.6 NM_001170720.1_1 - 5.1e-76 254.9 0.0 8.6e-76 254.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3513) Serine_rich PF08824.8 NM_001170720.1_1 - 2.2e-43 147.9 0.2 2.2e-43 147.9 0.2 1.8 2 0 0 2 2 2 1 Serine rich protein interaction domain SH3_1 PF00018.26 NM_001170720.1_1 - 1.2e-13 50.3 0.0 2.3e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001170720.1_1 - 3.1e-13 49.2 0.1 9.4e-13 47.7 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 NM_001170720.1_1 - 1.4e-10 40.5 0.0 2.6e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Vinculin PF01044.17 NM_001170720.1_1 - 0.0085 14.2 0.1 0.013 13.6 0.1 1.2 1 0 0 1 1 1 1 Vinculin family Alanine_zipper PF11839.6 NM_001170720.1_1 - 0.13 12.4 1.0 0.34 11.1 1.0 1.6 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Acyl-CoA_dh_C PF12806.5 NM_001170720.1_1 - 2.9 7.9 7.7 19 5.3 0.1 3.3 2 1 2 4 4 4 0 Acetyl-CoA dehydrogenase C-terminal like I_LWEQ PF01608.15 NM_001170720.1_1 - 3.2 7.9 5.4 2.3 8.3 1.6 2.7 2 1 1 3 3 3 0 I/LWEQ domain DEAD PF00270.27 NM_001320522.1_2 - 3.1e-26 92.1 0.0 5.4e-26 91.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001320522.1_2 - 3.3e-26 91.7 0.0 6.7e-26 90.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PUF PF00806.17 NM_174913.2_3 - 4.2e-11 41.8 0.0 2 8.1 0.0 7.2 8 0 0 8 8 8 5 Pumilio-family RNA binding repeat GAS PF13851.4 NM_198515.2_3 - 0.11 11.7 40.4 0.0072 15.6 31.7 2.5 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF1192 PF06698.9 NM_198515.2_3 - 1.4 8.9 9.2 0.73 9.8 1.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) CRAL_TRIO_N PF03765.13 NM_198515.2_3 - 2.2 8.4 6.9 3.1 7.9 0.0 3.5 4 0 0 4 4 4 0 CRAL/TRIO, N-terminal domain CLTH PF10607.7 NM_022762.4_1 - 6.4e-32 110.3 0.0 1.5e-31 109.1 0.0 1.6 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.4 NM_022762.4_1 - 0.00014 21.6 0.2 0.00014 21.6 0.2 2.0 2 0 0 2 2 2 1 RING-type zinc-finger Rtf2 PF04641.10 NM_022762.4_1 - 0.0063 15.8 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger Sec15 PF04091.10 NM_022762.4_1 - 0.054 12.8 0.1 0.082 12.2 0.1 1.2 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like TMEM237 PF15383.4 NM_001044385.2_1 - 2.8e-101 337.7 1.0 3.9e-101 337.2 1.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 237 Enolase_N PF03952.14 NM_001044385.2_2 - 3.7e-20 72.3 0.0 8.5e-20 71.1 0.0 1.5 2 0 0 2 2 2 1 Enolase, N-terminal domain zf-HC5HC2H PF13771.4 NM_032458.2_2 - 4.8e-33 113.1 30.2 5.2e-17 61.7 10.5 3.5 3 0 0 3 3 3 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 NM_032458.2_2 - 2.4e-12 46.8 27.9 2e-06 27.8 12.3 2.7 2 0 0 2 2 2 2 PHD-zinc-finger like domain Amidohydro_1 PF01979.18 NM_001288661.1_3 - 2e-32 112.7 0.0 2.5e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 NM_001288661.1_3 - 1.5e-09 37.8 0.1 5e-07 29.4 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_2 PF04909.12 NM_001288661.1_3 - 0.054 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Amidohydrolase Pkinase PF00069.23 NM_001004106.2_2 - 2.3e-68 230.3 0.0 2.9e-68 229.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001004106.2_2 - 4.9e-35 120.9 0.0 7e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 NM_001004106.2_2 - 5.4e-18 65.2 0.0 1.1e-17 64.3 0.0 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain Kinase-like PF14531.4 NM_001004106.2_2 - 5.1e-05 22.6 0.0 8e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RhoGAP PF00620.25 NM_001287242.1_2 - 8.2e-48 161.9 0.1 1.8e-47 160.8 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain Peptidase_M6 PF05547.9 NM_001287242.1_2 - 0.11 10.6 0.0 0.15 10.1 0.0 1.1 1 0 0 1 1 1 0 Immune inhibitor A peptidase M6 PRR20 PF15708.3 NM_198441.2_3 - 2.8e-98 328.2 16.9 3.5e-98 327.9 16.9 1.1 1 0 0 1 1 1 1 Proline-rich protein family 20 PSP PF04046.14 NM_017612.4_3 - 4.9e-17 61.4 0.1 1.1e-16 60.3 0.1 1.6 1 0 0 1 1 1 1 PSP zf-CCHC PF00098.21 NM_017612.4_3 - 4.4e-05 23.2 3.3 0.00011 22.0 3.3 1.7 1 0 0 1 1 1 1 Zinc knuckle Herpes_BLRF2 PF05812.10 NM_017612.4_3 - 0.053 13.5 0.7 0.14 12.2 0.7 1.7 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Cnn_1N PF07989.9 NM_017612.4_3 - 4.9 7.2 6.4 27 4.8 6.4 2.2 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 ZapB PF06005.10 NM_017612.4_3 - 9.5 6.6 8.6 0.73 10.2 2.1 2.6 2 0 0 2 2 2 0 Cell division protein ZapB CASP_C PF08172.10 NM_144659.5_3 - 0.07 12.3 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 CASP C terminal Thioredoxin_6 PF13848.4 NM_001300784.1_2 - 4.8e-28 98.2 0.4 6.6e-28 97.8 0.4 1.1 1 0 0 1 1 1 1 Thioredoxin-like domain Peptidase_C69 PF03577.13 NM_001145513.1_1 - 2.5e-05 23.5 0.0 3.7e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C69 AAT PF03417.14 NM_001145513.1_1 - 0.19 11.3 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase SAM_1 PF00536.28 NM_001037535.2_2 - 2.1e-18 66.4 0.0 4.1e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001037535.2_2 - 5.6e-06 26.2 0.0 1.2e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_001037535.2_2 - 0.019 14.8 0.0 0.052 13.4 0.0 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Bradykinin PF06753.10 NM_001206648.1_2 - 0.13 11.8 1.9 0.39 10.3 1.9 1.9 1 0 0 1 1 1 0 Bradykinin Proteasome PF00227.24 NM_002799.3_1 - 7e-50 169.0 0.1 8.9e-50 168.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.6 NM_002799.3_1 - 1.5e-16 59.4 1.6 3.6e-16 58.1 1.6 1.7 1 0 0 1 1 1 1 Proteasome beta subunits C terminal Imm45 PF15572.4 NM_002799.3_2 - 1.4 9.2 3.6 16 5.8 0.4 2.5 2 0 0 2 2 2 0 Immunity protein 45 Cadherin PF00028.15 NM_001171971.2_1 - 5.1e-73 241.5 0.2 7e-15 55.1 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain RTC PF01137.19 NM_001171971.2_1 - 0.12 11.3 0.0 0.28 10.2 0.0 1.5 1 0 0 1 1 1 0 RNA 3'-terminal phosphate cyclase Abhydrolase_6 PF12697.5 NM_001271593.1_3 - 7e-25 88.8 0.1 3.9e-24 86.3 0.0 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 NM_001271593.1_3 - 3.2e-12 46.5 0.0 5.2e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 NM_001271593.1_3 - 1.7e-07 30.6 0.0 2.7e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.18 NM_001271593.1_3 - 0.00013 22.1 0.0 0.00021 21.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.11 NM_001271593.1_3 - 0.013 15.1 0.1 0.02 14.5 0.1 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_3 PF07859.11 NM_001271593.1_3 - 0.013 15.2 0.1 0.02 14.6 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.18 NM_001271593.1_3 - 0.019 14.5 0.1 0.046 13.2 0.1 1.5 1 1 0 1 1 1 0 Putative esterase Lipase_3 PF01764.23 NM_001271593.1_3 - 0.12 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_2 PF02230.14 NM_001271593.1_3 - 0.13 12.0 0.7 12 5.5 0.1 2.3 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase FH2 PF02181.21 NM_001103184.3_2 - 7e-90 301.7 7.0 1e-89 301.2 7.0 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain Secretin_N_2 PF07655.11 NM_015409.4_1 - 1 9.8 13.1 2.3 8.7 13.1 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain CDK2AP PF09806.7 NM_015409.4_1 - 8.9 6.2 6.6 16 5.3 6.6 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein EP400_N PF15790.3 NM_015409.4_3 - 2.3e-236 785.2 29.1 2.3e-236 785.2 29.1 7.9 6 3 1 7 7 7 1 E1A-binding protein p400, N-terminal SNF2_N PF00176.21 NM_015409.4_3 - 1.4e-43 148.8 0.4 1.4e-43 148.8 0.4 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain HSA PF07529.11 NM_015409.4_3 - 3.6e-19 68.7 9.2 3.6e-19 68.7 9.2 4.9 5 1 1 6 6 6 1 HSA Helicase_C PF00271.29 NM_015409.4_3 - 3.4e-10 40.1 0.1 8.1e-10 38.9 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Myb_DNA-binding PF00249.29 NM_015409.4_3 - 0.003 17.6 0.1 0.0098 15.9 0.0 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.4 NM_015409.4_3 - 0.0057 16.9 0.0 0.0057 16.9 0.0 2.6 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 NM_015409.4_3 - 0.021 14.9 0.1 0.021 14.9 0.1 2.2 2 0 0 2 2 2 0 Myb-like DNA-binding domain DUF3304 PF11745.6 NM_015409.4_3 - 0.41 11.0 2.5 1.2 9.6 2.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3304) CLN3 PF02487.15 NM_015409.4_3 - 3 6.6 5.5 6.6 5.5 5.5 1.5 1 0 0 1 1 1 0 CLN3 protein HDA2-3 PF11496.6 NM_015409.4_3 - 7.3 5.5 8.6 0.16 10.9 0.1 2.4 3 0 0 3 3 3 0 Class II histone deacetylase complex subunits 2 and 3 AIB PF15334.4 NM_001287490.1_3 - 7.4e-181 600.5 10.7 8.6e-181 600.3 10.7 1.0 1 0 0 1 1 1 1 Aurora kinase A and ninein interacting protein MIF4G PF02854.17 NM_001194946.1_2 - 7.5e-69 231.5 9.6 1.2e-68 230.8 9.6 1.4 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.15 NM_001194946.1_2 - 5.3e-30 103.6 0.3 3.4e-29 101.0 0.1 2.4 2 1 0 2 2 2 1 MA3 domain W2 PF02020.16 NM_001194946.1_2 - 3.8e-18 65.3 0.9 3.8e-18 65.3 0.9 2.5 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Cep57_MT_bd PF06657.11 NM_001194946.1_2 - 1.7 9.0 6.3 0.91 9.9 3.0 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 IRK PF01007.18 NM_001260508.1_1 - 6.6e-81 271.7 1.2 9.5e-81 271.2 1.2 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel IRK PF01007.18 NM_001260508.1_3 - 7.4e-16 57.9 0.0 1.2e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel DUF1899 PF08953.9 NM_003389.3_3 - 6.6e-30 102.7 0.1 1.2e-29 101.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 NM_003389.3_3 - 1e-20 73.2 0.1 1.8e-20 72.4 0.1 1.4 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 NM_003389.3_3 - 2.6e-13 50.1 2.2 0.00055 20.6 0.1 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_003389.3_3 - 7.6e-05 22.8 0.0 0.013 15.6 0.0 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Basic PF01586.14 NM_002478.4_2 - 4e-29 101.5 0.3 9.7e-29 100.2 0.3 1.7 1 0 0 1 1 1 1 Myogenic Basic domain Myf5 PF12232.6 NM_002478.4_2 - 2e-24 86.0 4.7 4.5e-24 84.9 4.7 1.6 1 0 0 1 1 1 1 Myogenic determination factor 5 HLH PF00010.24 NM_002478.4_2 - 2.8e-14 52.7 2.3 4.8e-14 51.9 2.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Pkinase PF00069.23 NM_006549.3_2 - 1.9e-63 214.2 0.0 5e-63 212.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_006549.3_2 - 4.7e-32 111.2 0.0 1.2e-30 106.6 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_006549.3_2 - 6.4e-07 28.8 0.0 9.1e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SRP40_C PF05022.10 NM_006549.3_2 - 0.12 13.1 0.8 0.34 11.7 0.8 1.7 1 0 0 1 1 1 0 SRP40, C-terminal domain FERM_M PF00373.16 NM_001286491.1_1 - 5.2e-18 65.4 0.0 9.5e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.8 NM_001286491.1_1 - 9.6e-16 57.4 0.3 3.7e-15 55.5 0.2 2.1 3 0 0 3 3 3 1 FERM N-terminal domain FA PF08736.9 NM_001286491.1_2 - 6.4e-13 48.4 0.1 6.4e-13 48.4 0.1 1.9 2 0 0 2 2 2 1 FERM adjacent (FA) FERM_C PF09380.8 NM_001286491.1_2 - 2.4e-08 34.1 1.2 4.4e-08 33.3 1.2 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain RALF PF05498.9 NM_001323069.1_1 - 0.08 13.7 4.9 2.5 8.9 1.9 3.0 2 0 0 2 2 2 0 Rapid ALkalinization Factor (RALF) PFK PF00365.18 NM_001323069.1_2 - 2.3e-41 141.9 0.8 3.1e-41 141.4 0.8 1.1 1 0 0 1 1 1 1 Phosphofructokinase PFK PF00365.18 NM_001323069.1_3 - 1.5e-159 529.6 1.2 2.8e-92 308.9 0.3 2.1 2 0 0 2 2 2 2 Phosphofructokinase Hrs_helical PF12210.6 NM_001323069.1_3 - 0.22 12.0 1.1 20 5.7 0.0 2.8 3 0 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate SQHop_cyclase_C PF13243.4 NM_002340.5_2 - 1.4e-59 201.7 0.0 9.6e-56 189.1 0.0 2.2 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.4 NM_002340.5_2 - 2.2e-48 164.8 0.4 3.3e-43 147.7 0.0 4.3 3 1 2 5 5 5 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.19 NM_002340.5_2 - 2.7e-38 129.2 9.3 3.1e-11 42.7 0.0 6.1 5 0 0 5 5 5 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.8 NM_002340.5_2 - 0.011 14.9 0.0 30 3.7 0.0 3.3 2 1 1 3 3 3 0 Pectic acid lyase Zip PF02535.20 NM_152264.4_3 - 1.5e-51 175.4 7.2 2.8e-38 131.8 2.6 2.1 1 1 1 2 2 2 2 ZIP Zinc transporter Arm_2 PF04826.11 NM_016607.3_3 - 7.4e-112 372.8 5.5 9.2e-112 372.5 5.5 1.1 1 0 0 1 1 1 1 Armadillo-like Arm PF00514.21 NM_016607.3_3 - 0.3 11.1 1.6 2.7 8.0 0.0 2.7 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat PUL PF08324.9 NM_016607.3_3 - 0.71 9.0 5.1 1.4 8.0 5.1 1.4 1 0 0 1 1 1 0 PUL domain Pkinase PF00069.23 NM_001003788.2_3 - 4.8e-36 124.4 0.0 8.5e-36 123.5 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001003788.2_3 - 5.1e-24 84.8 0.0 4.7e-22 78.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase ATP1G1_PLM_MAT8 PF02038.14 NM_021603.3_2 - 9.9e-25 85.5 0.2 1.4e-24 85.0 0.2 1.2 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family Lig_chan PF00060.24 NM_138690.2_2 - 1.3e-28 99.6 0.0 1.9e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_138690.2_2 - 5.4e-26 90.9 0.0 3.5e-25 88.3 0.0 2.0 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_138690.2_2 - 3.4e-19 69.0 0.0 6.2e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.26 NM_138690.2_2 - 0.012 14.7 0.0 0.069 12.1 0.0 1.9 2 0 0 2 2 2 0 Receptor family ligand binding region RRS1 PF04939.10 NM_015169.3_3 - 4e-58 195.8 3.1 4e-58 195.8 3.1 2.2 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) CAP-ZIP_m PF15255.4 NM_052862.3_2 - 2.5e-20 73.0 1.8 2.5e-20 73.0 1.8 2.0 2 0 0 2 2 2 1 WASH complex subunit CAP-Z interacting, central region RCSD PF05177.10 NM_052862.3_2 - 3.6e-19 69.3 22.2 3.6e-19 69.3 22.2 3.7 4 1 0 4 4 4 1 RCSD region MAGE_N PF12440.6 NM_005363.3_1 - 8.5e-27 93.5 10.2 1.3e-26 93.0 10.2 1.3 1 0 0 1 1 1 1 Melanoma associated antigen family N terminal MAGE PF01454.17 NM_005363.3_1 - 3.3e-16 59.5 0.0 2.4e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 MAGE family Pkinase PF00069.23 NM_014791.3_2 - 8.8e-73 244.8 0.0 1.3e-72 244.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_014791.3_2 - 5e-40 137.3 0.0 7.9e-40 136.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 NM_014791.3_2 - 2.3e-14 52.8 0.2 5.2e-14 51.6 0.2 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.4 NM_014791.3_2 - 1.5e-08 34.2 0.0 2.1e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_014791.3_2 - 8.9e-06 25.1 0.1 2.3e-05 23.7 0.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_014791.3_2 - 0.0017 18.2 0.3 0.082 12.7 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.18 NM_014791.3_2 - 0.059 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Rho_GDI PF02115.15 NM_001185077.2_1 - 1.7e-80 269.2 0.3 2.3e-80 268.8 0.3 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor DUF4249 PF14054.4 NM_001185077.2_1 - 0.22 11.0 0.0 0.32 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4249) Kinesin PF00225.21 NM_001271928.1_3 - 8.5e-111 369.9 0.1 8.5e-111 369.9 0.1 2.8 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 NM_001271928.1_3 - 3.3e-24 85.4 0.0 3.3e-24 85.4 0.0 3.4 3 0 0 3 3 3 1 Microtubule binding Serum_albumin PF00273.18 NM_001204306.1_3 - 3e-86 287.5 31.9 1.2e-47 161.8 7.2 3.2 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 NM_001204306.1_3 - 1.3e-35 121.1 28.8 5.5e-32 109.4 2.7 5.5 4 2 2 6 6 6 4 Vitamin D binding protein, domain III Meis_PKNOX_N PF16493.3 NM_022062.2_3 - 5.6e-39 132.2 1.4 9.8e-39 131.5 1.4 1.4 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.9 NM_022062.2_3 - 2.1e-19 69.0 2.3 4.2e-19 68.0 2.3 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 NM_022062.2_3 - 2.6e-07 30.2 0.5 5.3e-07 29.2 0.5 1.5 1 0 0 1 1 1 1 Homeobox domain zf-C3HC4_4 PF15227.4 NM_001206626.1_1 - 2.2e-10 40.4 11.1 2.2e-10 40.4 11.1 2.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 NM_001206626.1_1 - 3.4e-08 33.5 0.0 7.2e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 SPRY domain zf-RING_UBOX PF13445.4 NM_001206626.1_1 - 8.2e-08 32.0 7.3 8.2e-08 32.0 7.3 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_001206626.1_1 - 4.1e-07 29.6 7.4 4.1e-07 29.6 7.4 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001206626.1_1 - 6.4e-07 29.0 5.8 6.4e-07 29.0 5.8 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 NM_001206626.1_1 - 4.1e-06 26.7 7.1 4.1e-06 26.7 7.1 4.0 4 1 0 4 4 4 1 B-box zinc finger zf-RING_2 PF13639.4 NM_001206626.1_1 - 0.0018 18.4 8.2 0.0018 18.4 8.2 2.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.4 NM_001206626.1_1 - 0.0018 17.9 6.3 0.0018 17.9 6.3 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.3 NM_001206626.1_1 - 0.027 14.5 2.9 0.027 14.5 2.9 2.4 2 1 0 2 2 2 0 zinc RING finger of MSL2 zf-Nse PF11789.6 NM_001206626.1_1 - 0.25 11.1 4.3 0.19 11.5 1.7 2.1 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.4 NM_001206626.1_1 - 4.7 7.0 15.9 2.7 7.8 6.7 3.2 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 NM_001206626.1_1 - 9.5 6.1 17.3 0.27 11.1 8.0 3.3 2 1 0 2 2 2 0 zinc-RING finger domain Arm PF00514.21 NM_144708.3_2 - 4.7e-26 89.8 23.1 6.1e-06 26.0 0.1 9.6 10 0 0 10 10 10 7 Armadillo/beta-catenin-like repeat Ank_2 PF12796.5 NM_144708.3_2 - 7.3e-20 71.2 9.3 7.4e-07 29.5 0.1 3.7 2 1 3 5 5 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_144708.3_2 - 2.2e-13 50.3 0.8 0.00067 20.0 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_144708.3_2 - 7e-13 47.4 6.5 0.043 14.2 0.1 6.8 6 0 0 6 6 6 4 Ankyrin repeat HEAT_2 PF13646.4 NM_144708.3_2 - 4.2e-08 33.3 0.0 0.72 10.1 0.0 5.2 3 1 4 7 7 7 3 HEAT repeats Ank_5 PF13857.4 NM_144708.3_2 - 3.5e-07 30.3 1.5 0.22 11.8 0.1 4.8 2 2 2 4 4 4 2 Ankyrin repeats (many copies) HEAT_EZ PF13513.4 NM_144708.3_2 - 0.00022 21.5 1.9 0.93 9.9 0.0 5.8 6 0 0 6 6 6 1 HEAT-like repeat Atx10homo_assoc PF09759.7 NM_144708.3_2 - 0.0059 16.5 6.9 0.026 14.5 1.9 4.3 3 2 2 5 5 5 1 Spinocerebellar ataxia type 10 protein domain Ank PF00023.28 NM_144708.3_2 - 0.0084 16.4 3.8 6.8 7.2 0.0 4.5 4 0 0 4 4 4 1 Ankyrin repeat HEAT PF02985.20 NM_144708.3_2 - 0.015 15.3 6.5 14 6.1 0.0 6.8 8 0 0 8 8 8 0 HEAT repeat Arm_2 PF04826.11 NM_144708.3_2 - 1.8 7.9 7.4 2.1 7.6 0.1 3.1 3 1 1 4 4 4 0 Armadillo-like Phostensin_N PF13916.4 NM_001134870.1_1 - 8.5e-35 118.9 4.2 8.5e-35 118.9 4.2 3.4 2 2 2 4 4 4 2 PP1-regulatory protein, Phostensin N-terminal Phostensin PF13914.4 NM_001134870.1_1 - 1.9e-33 115.9 0.2 6e-33 114.3 0.2 1.9 1 0 0 1 1 1 1 Phostensin PP1-binding and SH3-binding region Ank_2 PF12796.5 NM_001258205.1_2 - 2.7e-20 72.6 1.3 7.8e-09 35.9 0.3 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_001258205.1_2 - 2.8e-12 45.5 0.1 0.17 12.4 0.0 5.3 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.28 NM_001258205.1_2 - 4.1e-12 45.9 0.2 0.039 14.3 0.1 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ion_trans PF00520.29 NM_001258205.1_2 - 2.4e-10 39.9 22.4 2.4e-10 39.9 22.4 2.0 2 0 0 2 2 2 1 Ion transport protein Ank_5 PF13857.4 NM_001258205.1_2 - 4.1e-10 39.6 0.1 0.16 12.3 0.1 4.0 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_001258205.1_2 - 7.8e-07 29.4 0.3 0.044 14.3 0.0 4.4 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Pox_polyA_pol PF03296.11 NM_001258205.1_2 - 0.019 14.7 0.2 0.04 13.7 0.2 1.4 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase nucleotidyltransferase domain TSGP1 PF07771.9 NM_001258205.1_2 - 0.43 10.6 1.6 0.9 9.6 1.6 1.5 1 0 0 1 1 1 0 Tick salivary peptide group 1 Guanylate_cyc PF00211.18 NM_001291951.1_1 - 9.1e-67 224.1 0.0 1.3e-66 223.6 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.12 NM_001291951.1_1 - 8.9e-57 191.8 0.0 1.4e-56 191.2 0.0 1.3 1 0 0 1 1 1 1 Heme NO binding associated HNOB PF07700.13 NM_001291951.1_1 - 3.3e-50 170.1 0.2 2.9e-27 95.5 0.1 2.2 1 1 1 2 2 2 2 Haem-NO-binding 4_1_CTD PF05902.11 NM_001291951.1_1 - 0.14 12.2 0.1 0.25 11.4 0.1 1.3 1 0 0 1 1 1 0 4.1 protein C-terminal domain (CTD) TPT PF03151.14 NM_015945.11_1 - 2.7e-25 89.2 14.0 3.4e-25 88.9 14.0 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 NM_015945.11_1 - 3.6e-06 27.1 38.2 1.9e-05 24.7 10.9 2.5 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.9 NM_015945.11_1 - 5e-05 22.5 20.6 6.4e-05 22.2 20.6 1.1 1 0 0 1 1 1 1 UAA transporter family TNF PF00229.16 NM_001190942.1_3 - 5.7e-45 152.2 0.9 1.3e-44 151.1 0.9 1.6 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 NM_001190942.1_3 - 0.061 13.4 3.3 1.6 8.8 0.0 2.3 1 1 1 2 2 2 0 C1q domain OATP PF03137.18 NM_005630.2_2 - 1.8e-175 584.2 15.7 2.2e-175 583.9 15.7 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 NM_005630.2_2 - 1.6e-19 69.9 37.2 1.6e-19 69.9 30.2 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.13 NM_005630.2_2 - 2.1e-07 30.9 3.7 4.2e-07 29.9 3.7 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 NM_005630.2_2 - 0.0012 18.6 2.6 0.0033 17.3 2.6 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain HLH PF00010.24 NM_020999.3_1 - 1.3e-15 56.9 0.1 2.2e-15 56.2 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Umbravirus_LDM PF04817.10 NM_020999.3_1 - 0.01 15.1 4.8 0.018 14.3 4.8 1.3 1 0 0 1 1 1 0 Umbravirus long distance movement (LDM) family RUN PF02759.17 NM_001321381.1_1 - 8.5e-34 116.3 0.0 1.4e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 RUN domain DUF1192 PF06698.9 NM_001321381.1_1 - 0.3 11.1 1.5 0.6 10.1 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) SCAN PF02023.15 NM_025231.2_1 - 7.6e-43 144.1 2.9 1.4e-42 143.3 2.9 1.5 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 NM_025231.2_1 - 2.9e-28 96.9 23.9 7.1e-10 38.8 0.6 6.0 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 NM_025231.2_1 - 1.4e-25 88.1 23.4 1.2e-06 28.5 3.9 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_025231.2_1 - 2.5e-11 43.3 36.0 0.00087 19.8 2.8 5.3 6 0 0 6 6 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_025231.2_1 - 1.1e-08 34.7 23.8 0.0018 18.1 3.6 4.8 4 1 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_025231.2_1 - 9.9e-07 28.8 6.7 0.3 11.3 1.8 4.7 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_025231.2_1 - 3e-06 27.0 12.4 1 9.3 0.7 4.5 4 0 0 4 4 4 3 XPA protein N-terminal ADK_lid PF05191.12 NM_025231.2_1 - 5.3e-05 23.0 10.6 0.00026 20.8 2.1 3.5 3 1 0 3 3 2 1 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 NM_025231.2_1 - 0.0003 20.7 24.5 0.0025 17.8 3.1 4.2 3 2 0 3 3 3 2 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_025231.2_1 - 0.004 17.7 8.6 0.15 12.7 2.5 2.6 1 1 1 2 2 2 2 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_025231.2_1 - 0.0045 16.6 21.4 0.46 10.1 2.1 5.0 5 0 0 5 5 5 3 zinc-finger C2H2-type SprT-like PF10263.7 NM_025231.2_1 - 0.0068 16.1 12.8 0.078 12.7 5.4 2.5 1 1 1 2 2 2 2 SprT-like family zf-trcl PF13451.4 NM_025231.2_1 - 0.015 15.0 9.6 9.8 6.0 0.3 4.6 4 0 0 4 4 4 0 Probable zinc-ribbon domain zf-met PF12874.5 NM_025231.2_1 - 0.03 14.6 17.0 0.94 9.8 0.1 4.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type C1_1 PF00130.20 NM_025231.2_1 - 0.034 13.9 17.2 0.054 13.3 1.2 4.4 2 1 3 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HypA PF01155.17 NM_025231.2_1 - 0.036 13.9 6.9 0.53 10.2 1.1 2.7 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ZZ PF00569.15 NM_025231.2_1 - 0.048 13.3 15.0 3 7.6 0.0 4.8 5 0 0 5 5 5 0 Zinc finger, ZZ type CpXC PF14353.4 NM_025231.2_1 - 0.092 12.6 5.6 13 5.7 0.0 4.2 2 1 1 3 3 3 0 CpXC protein C1_4 PF07975.10 NM_025231.2_1 - 0.1 12.8 12.2 3.9 7.7 0.3 4.0 1 1 3 4 4 4 0 TFIIH C1-like domain YhfH PF14149.4 NM_025231.2_1 - 0.12 12.2 12.3 13 5.7 0.2 4.5 4 0 0 4 4 4 0 YhfH-like protein DNA_RNApol_7kD PF03604.11 NM_025231.2_1 - 0.18 11.3 11.2 13 5.5 0.2 4.6 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit zf-AN1 PF01428.14 NM_025231.2_1 - 0.41 10.7 18.8 14 5.8 1.0 4.9 2 1 2 4 4 4 0 AN1-like Zinc finger Zn_ribbon_recom PF13408.4 NM_025231.2_1 - 0.98 9.8 11.9 29 5.1 0.8 4.4 1 1 3 4 4 4 0 Recombinase zinc beta ribbon domain Zn_Tnp_IS1595 PF12760.5 NM_025231.2_1 - 1.5 8.8 19.5 5.9 6.8 1.7 4.5 3 1 1 4 4 4 0 Transposase zinc-ribbon domain zf-RING_7 PF02591.13 NM_025231.2_1 - 1.7 8.8 11.0 4.2 7.5 0.4 4.1 4 0 0 4 4 4 0 C4-type zinc ribbon domain DUF3268 PF11672.6 NM_025231.2_1 - 1.7 8.8 6.4 6.3 7.0 0.8 2.5 1 1 0 2 2 2 0 zinc-finger-containing domain zf-Mss51 PF13824.4 NM_025231.2_1 - 2.8 8.0 17.1 2.9 7.9 0.0 4.4 2 1 1 3 3 2 0 Zinc-finger of mitochondrial splicing suppressor 51 HNH PF01844.21 NM_025231.2_1 - 9.4 6.4 20.5 6.8 6.8 0.1 4.9 5 0 0 5 5 5 0 HNH endonuclease SPAN-X PF07458.10 NM_001009615.2_1 - 7.1e-47 157.6 8.4 7.1e-47 157.6 8.4 3.1 2 1 2 4 4 4 1 Sperm protein associated with nucleus, mapped to X chromosome BUD22 PF09073.8 NM_001009615.2_1 - 1.5 8.0 33.9 1.8 7.7 33.9 1.2 1 0 0 1 1 1 0 BUD22 RHH_3 PF12651.5 NM_001009615.2_2 - 0.0064 16.3 12.9 83 3.1 0.0 6.6 7 0 0 7 7 7 0 Ribbon-helix-helix domain CUT PF02376.13 NM_001009615.2_2 - 0.077 13.0 7.1 8.2 6.5 3.1 2.9 1 1 1 2 2 2 0 CUT domain APOC4 PF15119.4 NM_001009615.2_2 - 3.5 7.8 30.6 8.6 6.6 0.5 6.1 2 1 4 6 6 6 0 Apolipoprotein C4 DUF2883 PF11097.6 NM_001009615.2_2 - 5.2 7.1 9.7 32 4.6 1.1 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2883) zf-MIZ PF02891.18 NM_174929.2_3 - 5.8e-23 80.2 4.5 5.8e-23 80.2 4.5 2.7 3 0 0 3 3 3 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 NM_174929.2_3 - 1.8e-05 24.3 1.1 1.8e-05 24.3 1.1 2.3 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit MAGE_N PF12440.6 NM_001011550.1_3 - 1.4e-24 86.5 13.6 1.4e-24 86.5 13.6 1.6 2 0 0 2 2 2 1 Melanoma associated antigen family N terminal MAGE PF01454.17 NM_001011550.1_3 - 2.9e-14 53.1 0.0 5.9e-12 45.6 0.0 2.2 1 1 0 1 1 1 1 MAGE family DUF3098 PF11297.6 NM_001011550.1_3 - 0.055 13.0 0.1 0.097 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) CCDC92 PF14916.4 NM_001304960.1_2 - 7e-24 83.2 9.8 9.5e-23 79.6 3.4 2.7 2 0 0 2 2 2 2 Coiled-coil domain of unknown function Exonuc_VII_L PF02601.13 NM_001304960.1_2 - 0.25 10.7 8.2 0.38 10.1 8.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6 PF04111.10 NM_001304960.1_2 - 0.3 10.3 18.5 0.45 9.7 18.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF3584 PF12128.6 NM_001304960.1_2 - 0.75 7.1 14.6 0.98 6.7 14.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4407 PF14362.4 NM_001304960.1_2 - 0.94 8.6 7.7 1.5 8.0 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NYD-SP28 PF14772.4 NM_001304960.1_2 - 2.4 8.1 14.1 2.3 8.2 11.0 2.1 1 1 1 2 2 2 0 Sperm tail FlxA PF14282.4 NM_001304960.1_2 - 3.4 7.6 14.4 0.59 10.0 4.6 3.0 1 1 1 3 3 3 0 FlxA-like protein IncA PF04156.12 NM_001304960.1_2 - 3.9 7.1 24.8 5.7e+02 0.0 24.8 2.7 1 1 0 1 1 1 0 IncA protein Atg14 PF10186.7 NM_001304960.1_2 - 4.4 6.2 18.5 11 4.9 18.5 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Reo_sigmaC PF04582.10 NM_001304960.1_2 - 6.5 5.9 7.4 9.8 5.3 5.9 1.7 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Fez1 PF06818.13 NM_001304960.1_2 - 6.9 6.9 17.1 8.4 6.6 15.4 1.8 1 1 0 1 1 1 0 Fez1 TPR_MLP1_2 PF07926.10 NM_001304960.1_2 - 9.8 6.1 23.7 3.8 7.5 0.2 3.1 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Annexin PF00191.18 NM_001156.4_1 - 2.5e-99 325.2 6.7 3.5e-26 90.9 0.4 4.2 4 0 0 4 4 4 4 Annexin RhoGEF67_u2 PF16614.3 NM_001320854.1_1 - 2.2e-49 165.9 4.9 6.9e-49 164.3 4.9 1.8 1 0 0 1 1 1 1 Unstructured region two on RhoGEF 6 and 7 RhoGEF PF00621.18 NM_001320854.1_1 - 1.2e-32 113.5 2.1 2.5e-32 112.4 2.1 1.6 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 NM_001320854.1_1 - 8.1e-09 35.8 0.0 1.8e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 PH domain Gelsolin PF00626.20 NM_001127665.1_1 - 7.6e-109 355.6 0.0 7.4e-20 70.5 0.0 6.2 6 0 0 6 6 6 6 Gelsolin repeat Maf1 PF09174.8 NM_032272.4_1 - 4.4e-63 212.0 0.0 7.8e-63 211.2 0.0 1.4 1 0 0 1 1 1 1 Maf1 regulator Mito_fiss_reg PF05308.9 NM_032272.4_2 - 0.21 11.5 6.9 0.048 13.6 1.9 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator LAS2 PF15792.3 NM_001288982.1_1 - 7.3e-16 58.4 1.3 7.3e-16 58.4 1.3 2.7 2 1 0 2 2 2 1 Lung adenoma susceptibility protein 2 Pkinase PF00069.23 NM_002745.4_1 - 2.5e-67 226.9 0.0 3.3e-67 226.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_002745.4_1 - 6.8e-34 117.2 0.0 1.1e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_002745.4_1 - 0.0089 15.8 0.1 0.015 15.1 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Mito_carr PF00153.25 NM_001317814.1_1 - 5.3e-52 173.6 2.5 4.6e-19 68.0 0.3 3.4 2 1 1 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.25 NM_001317814.1_2 - 0.0085 15.9 0.1 0.016 15.0 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial carrier protein GST_N PF02798.18 NM_000851.3_3 - 2e-20 72.8 0.0 4.3e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 NM_000851.3_3 - 6.5e-14 51.8 0.1 1.3e-13 50.8 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_000851.3_3 - 3.3e-13 49.5 0.2 6e-13 48.7 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 NM_000851.3_3 - 0.001 18.7 0.1 0.0039 16.8 0.1 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 NM_000851.3_3 - 0.0087 15.9 0.0 0.038 13.8 0.0 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 NM_000851.3_3 - 0.016 15.5 0.0 0.033 14.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain HEM4 PF02602.13 NM_001324038.1_3 - 1.1e-31 109.8 0.0 5.9e-15 55.1 0.0 2.1 1 1 1 2 2 2 2 Uroporphyrinogen-III synthase HemD adh_short PF00106.23 NM_001267869.1_2 - 8e-18 64.5 0.0 1.2e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_001267869.1_2 - 1.7e-07 30.9 0.0 2.6e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.8 NM_001267869.1_2 - 0.04 13.1 0.0 0.057 12.6 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) adh_short PF00106.23 NM_001267869.1_3 - 0.0012 18.2 0.1 0.0017 17.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase 7tm_4 PF13853.4 NM_012377.1_1 - 4.2e-54 184.0 18.1 4.9e-54 183.8 18.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_012377.1_1 - 4.6e-26 91.5 24.0 2e-25 89.4 24.0 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_012377.1_1 - 3.7e-06 26.4 22.9 6.2e-06 25.6 22.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Sema PF01403.17 NM_001105543.1_2 - 1.2e-70 238.2 0.0 1.7e-70 237.8 0.0 1.1 1 0 0 1 1 1 1 Sema domain Lyase_1 PF00206.18 NM_000048.3_1 - 5.5e-107 357.6 0.0 1.2e-106 356.5 0.0 1.5 2 0 0 2 2 2 1 Lyase ASL_C2 PF14698.4 NM_000048.3_1 - 2.9e-21 75.9 0.0 2.2e-20 73.1 0.0 2.3 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal T4SS_CagC PF16943.3 NM_000048.3_1 - 0.033 14.2 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 Cag pathogenicity island, type IV secretory system PC-Esterase PF13839.4 NM_001271168.1_1 - 6.7e-06 25.9 0.1 6.7e-06 25.9 0.1 2.6 2 1 1 3 3 3 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p NUDIX PF00293.26 NM_001321647.1_3 - 6.9e-15 55.1 0.0 1.4e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain PH PF00169.27 NM_152406.3_3 - 4.4e-19 68.8 0.2 5.4e-08 33.1 0.2 2.5 2 0 0 2 2 2 2 PH domain PH_11 PF15413.4 NM_152406.3_3 - 0.00028 21.1 0.3 0.093 13.0 0.0 3.0 2 1 0 2 2 2 2 Pleckstrin homology domain Fib_alpha PF08702.8 NM_152406.3_3 - 0.36 10.9 3.3 0.74 9.9 3.3 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Ras PF00071.20 NM_004310.4_2 - 6.5e-44 149.3 0.0 8.4e-44 148.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_004310.4_2 - 1.1e-21 77.1 0.0 1.6e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_004310.4_2 - 4.6e-07 29.3 0.0 6.3e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_004310.4_2 - 0.045 13.7 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase WH1 PF00568.21 NM_001277078.1_1 - 1.1e-34 118.6 0.2 1.7e-34 117.9 0.2 1.3 1 0 0 1 1 1 1 WH1 domain Forkhead PF00250.16 NM_005250.2_3 - 1.1e-37 128.1 0.0 2.5e-37 126.9 0.0 1.6 1 0 0 1 1 1 1 Forkhead domain I-set PF07679.14 NM_001242608.1_1 - 1.4e-78 258.9 9.1 5e-19 68.0 0.5 5.4 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001242608.1_1 - 8.3e-70 231.3 11.7 2.4e-17 63.2 0.1 5.6 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 NM_001242608.1_1 - 8.8e-53 176.3 5.4 1.8e-10 40.7 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 NM_001242608.1_1 - 2.1e-43 146.4 4.1 1.3e-08 34.9 0.3 5.5 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.19 NM_001242608.1_1 - 6.2e-25 87.2 0.2 2.3e-12 46.9 0.1 2.7 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.15 NM_001242608.1_1 - 1e-19 70.5 7.0 0.0012 18.9 0.0 7.3 5 3 0 5 5 5 4 Immunoglobulin V-set domain C1-set PF07654.13 NM_001242608.1_1 - 6.2e-14 52.1 6.6 0.00048 20.4 0.1 5.5 5 0 0 5 5 5 4 Immunoglobulin C1-set domain C2-set_2 PF08205.10 NM_001242608.1_1 - 9.4e-12 44.7 3.2 0.031 14.2 0.0 5.1 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 NM_001242608.1_1 - 6e-10 39.3 3.1 0.031 14.6 0.1 5.7 5 1 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 NM_001242608.1_1 - 3.5e-09 36.4 0.5 0.74 9.8 0.0 4.8 5 0 0 5 5 5 4 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 NM_001242608.1_1 - 4.1e-06 26.9 5.3 5.4 7.3 0.4 6.2 5 1 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.6 NM_001242608.1_1 - 0.0044 17.1 1.1 25 5.0 0.0 4.2 4 0 0 4 4 4 0 Natural killer cell receptor 2B4 Pur_ac_phosph_N PF16656.3 NM_001242608.1_1 - 0.026 14.9 0.1 1.2 9.6 0.0 3.2 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Collagen_bind_2 PF12904.5 NM_001242608.1_1 - 0.083 12.7 1.4 0.54 10.1 0.1 2.7 3 0 0 3 3 2 0 Putative collagen-binding domain of a collagenase V-set PF07686.15 NM_001256111.2_3 - 2.3e-47 159.5 12.8 2.6e-09 37.1 0.2 7.5 6 1 0 7 7 7 7 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001256111.2_3 - 1.1e-39 134.7 4.0 3e-05 24.4 0.0 8.1 7 0 0 7 7 7 7 Immunoglobulin domain ig PF00047.23 NM_001256111.2_3 - 3.3e-29 100.8 10.7 0.00018 21.5 0.0 8.2 7 1 0 7 7 7 6 Immunoglobulin domain I-set PF07679.14 NM_001256111.2_3 - 4e-29 100.4 4.6 4.5e-06 26.5 0.1 8.5 7 2 1 8 8 8 6 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001256111.2_3 - 1.1e-16 60.8 6.5 0.15 12.3 0.0 10.2 7 5 2 9 9 9 6 Immunoglobulin domain Izumo-Ig PF16706.3 NM_001256111.2_3 - 3.5e-10 39.7 1.8 1.1 9.2 0.0 6.9 6 1 1 7 7 7 3 Izumo-like Immunoglobulin domain C2-set PF05790.13 NM_001256111.2_3 - 0.00052 20.0 10.1 0.35 10.9 0.1 5.9 7 0 0 7 7 7 1 Immunoglobulin C2-set domain FTCD_N PF07837.10 NM_206965.1_3 - 5.9e-71 237.8 0.0 1e-70 237.0 0.0 1.4 1 0 0 1 1 1 1 Formiminotransferase domain, N-terminal subdomain FTCD PF02971.12 NM_206965.1_3 - 5.7e-70 234.0 0.0 1.6e-69 232.5 0.0 1.8 2 0 0 2 2 2 1 Formiminotransferase domain FTCD_C PF04961.10 NM_206965.1_3 - 2.1e-67 226.2 0.2 3.4e-67 225.6 0.2 1.3 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase NHL PF01436.19 NM_001012754.3_3 - 1.1e-10 40.9 5.1 2.1e-08 33.7 0.1 4.6 5 0 0 5 5 5 2 NHL repeat SGL PF08450.10 NM_001012754.3_3 - 0.00038 20.0 0.1 0.0069 15.9 0.1 2.6 2 1 1 3 3 3 1 SMP-30/Gluconolaconase/LRE-like region Lactonase PF10282.7 NM_001012754.3_3 - 0.064 12.4 0.0 3.1 6.8 0.0 1.9 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller Xlink PF00193.15 NM_001164097.1_3 - 1.9e-60 201.1 7.9 7.4e-32 109.5 0.3 3.7 3 1 1 4 4 4 2 Extracellular link domain Lectin_C PF00059.19 NM_001164097.1_3 - 5.2e-18 65.6 1.6 5.2e-18 65.6 1.6 3.9 4 0 0 4 4 4 1 Lectin C-type domain V-set PF07686.15 NM_001164097.1_3 - 1.5e-17 63.6 0.3 8.8e-17 61.1 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain EGF PF00008.25 NM_001164097.1_3 - 2e-13 50.2 22.0 1.7e-06 28.1 9.4 2.8 2 0 0 2 2 2 2 EGF-like domain Sushi PF00084.18 NM_001164097.1_3 - 7.2e-07 29.6 0.2 4e-06 27.2 0.2 2.4 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) hEGF PF12661.5 NM_001164097.1_3 - 0.00027 21.3 30.9 0.00094 19.6 3.5 3.6 4 0 0 4 4 4 2 Human growth factor-like EGF EGF_2 PF07974.11 NM_001164097.1_3 - 0.059 13.6 22.4 0.4 11.0 8.9 2.8 2 0 0 2 2 2 0 EGF-like domain EGF_CA PF07645.13 NM_001164097.1_3 - 0.9 9.7 30.5 0.29 11.3 9.6 3.6 3 0 0 3 3 3 0 Calcium-binding EGF domain Laminin_EGF PF00053.22 NM_001164097.1_3 - 4.2 7.4 20.7 6.5 6.9 5.3 3.0 1 1 1 2 2 2 0 Laminin EGF domain A_deamin PF02137.16 NM_015833.3_1 - 8e-113 377.0 0.0 1.1e-112 376.6 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 NM_015833.3_1 - 6.3e-27 93.9 0.0 2.6e-13 50.3 0.0 2.6 2 0 0 2 2 2 2 Double-stranded RNA binding motif STAT_bind PF02864.13 NM_005419.3_3 - 1.8e-64 217.9 0.0 2.8e-64 217.3 0.0 1.3 1 0 0 1 1 1 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 NM_005419.3_3 - 1.5e-50 171.4 9.7 2.9e-50 170.5 9.7 1.5 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT2_C PF12188.6 NM_005419.3_3 - 9.6e-33 111.8 0.7 9.6e-33 111.8 0.7 2.9 5 0 0 5 5 5 1 Signal transducer and activator of transcription 2 C terminal STAT_int PF02865.15 NM_005419.3_3 - 1.3e-30 106.2 2.9 1.3e-30 106.2 2.9 2.6 2 1 1 3 3 3 1 STAT protein, protein interaction domain SH2 PF00017.22 NM_005419.3_3 - 7.8e-11 41.8 0.0 1.7e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 SH2 domain CorA PF01544.16 NM_005419.3_3 - 0.044 13.0 3.8 0.075 12.2 3.8 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein I-set PF07679.14 NM_001172309.1_1 - 1.4e-15 56.9 0.0 2.9e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001172309.1_1 - 3.8e-09 36.9 0.0 8.4e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 NM_001172309.1_1 - 2.3e-06 27.6 0.0 5.6e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_001172309.1_1 - 0.015 15.5 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Septin PF00735.16 NM_145799.3_2 - 9.1e-95 317.0 0.6 1.4e-94 316.4 0.6 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 NM_145799.3_2 - 0.00019 21.3 0.0 0.00036 20.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 NM_145799.3_2 - 0.0061 16.7 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain Roc PF08477.11 NM_145799.3_2 - 0.014 15.5 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_145799.3_2 - 0.019 15.2 0.3 0.048 13.9 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain Atg14 PF10186.7 NM_145799.3_2 - 0.035 13.1 10.3 0.062 12.2 10.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_29 PF13555.4 NM_145799.3_2 - 0.066 12.8 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.4 NM_145799.3_2 - 0.086 13.2 13.6 11 6.3 11.9 2.5 2 0 0 2 2 2 0 AAA domain IMD PF08397.9 NM_145799.3_2 - 0.099 11.9 11.7 0.17 11.1 11.7 1.2 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF2959 PF11172.6 NM_145799.3_2 - 0.12 12.3 6.6 0.19 11.6 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) GTP_EFTU PF00009.25 NM_145799.3_2 - 0.25 10.8 4.0 5.4 6.4 0.0 2.7 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Fzo_mitofusin PF04799.11 NM_145799.3_2 - 0.3 10.5 8.2 0.57 9.6 8.2 1.3 1 0 0 1 1 1 0 fzo-like conserved region TPR_MLP1_2 PF07926.10 NM_145799.3_2 - 1.6 8.7 17.0 2.6 8.0 17.0 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Dynamin_N PF00350.21 NM_145799.3_2 - 3.1 7.7 5.1 15 5.4 0.0 2.2 2 0 0 2 2 2 0 Dynamin family DUF87 PF01935.15 NM_145799.3_2 - 3.9 7.3 5.6 10 6.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF87 APG6 PF04111.10 NM_145799.3_2 - 4.3 6.5 12.9 7.2 5.8 12.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 CC2-LZ PF16516.3 NM_001258456.1_1 - 3.7e-07 30.3 22.1 3.7e-07 30.3 22.1 6.0 4 1 1 5 5 5 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF4407 PF14362.4 NM_001258456.1_1 - 0.65 9.2 48.8 1.5 8.0 18.2 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.10 NM_001258456.1_1 - 2.4 8.6 18.5 3.6 8.0 0.7 4.6 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein ANF_receptor PF01094.26 NM_001320630.1_1 - 8.1e-78 261.8 0.0 9.4e-78 261.6 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.4 NM_001320630.1_1 - 2.4e-08 33.9 0.0 3.3e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein ADH_zinc_N PF00107.24 NM_000672.3_2 - 3.3e-23 81.9 0.2 6.2e-23 81.0 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 NM_000672.3_2 - 4.1e-22 78.0 1.5 9.3e-22 76.8 1.5 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 NM_000672.3_2 - 0.00053 20.9 0.0 0.00091 20.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 NM_000672.3_2 - 0.0022 17.5 0.1 0.0036 16.8 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IGFBP PF00219.16 NM_000672.3_2 - 0.01 16.3 0.2 0.031 14.8 0.2 1.8 1 0 0 1 1 1 0 Insulin-like growth factor binding protein 2-Hacid_dh_C PF02826.17 NM_000672.3_2 - 0.028 13.6 0.1 0.054 12.7 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NDUF_B5 PF09781.7 NM_002492.3_3 - 3.1e-87 290.9 0.0 3.8e-87 290.6 0.0 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit PI-PLC-X PF00388.17 NM_001303013.1_1 - 5.2e-64 214.1 0.0 1.2e-63 212.9 0.1 1.6 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 NM_001303013.1_1 - 8.9e-40 135.5 0.7 1.5e-39 134.8 0.7 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.28 NM_001303013.1_1 - 1.4e-15 57.3 0.0 2.7e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.9 NM_001303013.1_1 - 2.1e-15 56.9 0.0 3.6e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_7 PF13499.4 NM_001303013.1_1 - 2.8e-11 43.6 0.6 6.7e-11 42.4 0.2 1.8 2 0 0 2 2 2 1 EF-hand domain pair PH_12 PF16457.3 NM_001303013.1_1 - 2e-08 34.7 0.0 5.7e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_1 PF00036.30 NM_001303013.1_1 - 5.6e-08 31.7 0.9 0.00057 19.1 0.0 2.7 2 1 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_001303013.1_1 - 2.1e-06 27.1 0.6 0.0065 16.2 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_10 PF14788.4 NM_001303013.1_1 - 1e-05 25.2 0.1 2.2e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 EF hand PH PF00169.27 NM_001303013.1_1 - 0.00044 20.6 0.0 0.00081 19.7 0.0 1.4 1 0 0 1 1 1 1 PH domain EF-hand_5 PF13202.4 NM_001303013.1_1 - 0.0011 18.2 1.9 0.0019 17.5 0.1 2.1 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 NM_001303013.1_1 - 0.0044 16.6 3.0 0.048 13.3 0.1 3.1 2 1 1 3 3 3 1 EF-hand domain pair Mcp5_PH PF12814.5 NM_001303013.1_1 - 0.052 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology EF-hand_4 PF12763.5 NM_001303013.1_1 - 0.074 12.9 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand ABC_tran_Xtn PF12848.5 NM_001303013.1_2 - 0.14 12.1 0.5 0.24 11.3 0.5 1.3 1 0 0 1 1 1 0 ABC transporter DUF3429 PF11911.6 NM_016486.3_2 - 2.9e-32 111.8 10.2 4e-32 111.3 10.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) Herpes_UL52 PF03121.13 NM_001300768.1_2 - 1.1e-16 60.3 0.2 2e-16 59.6 0.2 1.4 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase DNA_primase_S PF01896.17 NM_001300768.1_2 - 0.00027 21.0 0.0 0.00055 20.0 0.0 1.5 1 0 0 1 1 1 1 DNA primase small subunit Calsarcin PF05556.9 NM_001122853.2_1 - 1.1e-32 113.3 0.0 1.7e-32 112.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) Vinculin PF01044.17 NM_001324008.1_1 - 5.1e-36 124.2 0.8 6.5e-36 123.9 0.8 1.0 1 0 0 1 1 1 1 Vinculin family Vinculin PF01044.17 NM_001324008.1_2 - 6.7e-168 560.7 15.1 8.5e-168 560.4 15.1 1.0 1 0 0 1 1 1 1 Vinculin family I_LWEQ PF01608.15 NM_001324008.1_2 - 0.17 12.0 16.2 1.2 9.2 9.0 3.6 2 2 0 2 2 2 0 I/LWEQ domain DivIC PF04977.13 NM_001324008.1_2 - 0.46 10.2 2.5 0.53 10.0 0.4 2.2 2 0 0 2 2 2 0 Septum formation initiator WH2 PF02205.18 NM_001077269.1_3 - 4.5e-11 42.1 1.2 3.4e-10 39.3 1.1 2.4 2 0 0 2 2 2 1 WH2 motif CAP_N PF01213.17 NM_001077269.1_3 - 0.0017 17.8 5.2 0.0017 17.8 5.2 7.1 2 1 5 7 7 7 1 Adenylate cyclase associated (CAP) N terminal GRP PF07172.9 NM_001077269.1_3 - 0.19 12.3 21.4 0.36 11.4 21.4 1.3 1 0 0 1 1 1 0 Glycine rich protein family Vps39_2 PF10367.7 NM_004257.5_3 - 1.2e-30 106.0 0.0 2.6e-30 104.9 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.7 NM_004257.5_3 - 1e-22 80.4 2.7 1e-22 80.4 2.7 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.18 NM_004257.5_3 - 5.8e-16 58.5 8.9 1.8e-10 40.7 0.3 2.4 2 0 0 2 2 2 2 Region in Clathrin and VPS CNH PF00780.20 NM_004257.5_3 - 3.2e-10 39.9 0.0 7.7e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 CNH domain NUT PF12881.5 NM_001284293.1_1 - 2.4e-277 922.1 34.0 1.2e-222 741.3 17.7 2.3 2 0 0 2 2 2 2 NUT protein Ank_2 PF12796.5 NM_130768.2_1 - 3.4e-31 107.5 3.4 1.5e-15 57.4 0.3 3.5 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_130768.2_1 - 1.9e-23 82.0 0.7 1.2e-09 38.1 0.0 4.7 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_130768.2_1 - 1.5e-22 78.8 0.7 7.5e-06 26.0 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.4 NM_130768.2_1 - 1.6e-19 67.7 0.2 0.00024 21.2 0.0 5.7 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.4 NM_130768.2_1 - 3.3e-19 68.8 0.2 1.6e-11 44.4 0.0 3.6 1 1 3 4 4 4 3 Ankyrin repeats (many copies) SAM_2 PF07647.15 NM_130768.2_1 - 1.9e-07 31.0 0.2 4.9e-07 29.6 0.2 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_130768.2_1 - 2.3e-06 27.8 0.4 5.3e-06 26.6 0.4 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF1359 PF07097.9 NM_130768.2_1 - 0.027 14.5 2.9 4.5 7.4 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1359) DUF342 PF03961.11 NM_130768.2_1 - 0.66 8.4 3.1 1.2 7.5 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) fn3 PF00041.19 NM_001306131.1_2 - 1.1e-234 759.5 83.1 3.8e-20 71.9 0.2 15.3 15 0 0 15 15 15 15 Fibronectin type III domain fn1 PF00039.16 NM_001306131.1_2 - 8.7e-145 470.5 172.7 5.4e-15 55.2 6.2 13.3 14 0 0 14 14 14 12 Fibronectin type I domain fn2 PF00040.17 NM_001306131.1_2 - 6.3e-32 109.4 30.1 3.1e-17 62.4 6.6 3.5 3 0 0 3 3 2 2 Fibronectin type II domain Pur_ac_phosph_N PF16656.3 NM_001306131.1_2 - 5.1e-30 103.8 52.8 0.0022 18.4 0.0 17.4 13 8 1 14 14 14 11 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 NM_001306131.1_2 - 3.4e-29 101.0 15.9 0.011 16.0 0.1 13.7 14 1 1 15 15 15 7 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 NM_001306131.1_2 - 2.5e-17 62.9 0.0 2.5 8.3 0.0 12.2 14 0 0 14 14 14 3 Interferon-alpha/beta receptor, fibronectin type III DUF4959 PF16323.3 NM_001306131.1_2 - 2.7e-07 30.7 5.1 7.1 6.9 0.0 7.7 6 1 2 8 8 7 2 Domain of unknown function (DUF4959) DUF1410 PF07198.9 NM_001306131.1_2 - 1.5e-06 28.5 0.7 6.3 7.3 0.0 6.6 7 0 0 7 7 7 2 Protein of unknown function (DUF1410) DUF4912 PF16258.3 NM_001306131.1_2 - 2.1e-06 27.8 0.0 3 7.9 0.0 6.6 6 1 1 7 7 7 1 Domain of unknown function (DUF4912) Glyco_hydro_66 PF13199.4 NM_001306131.1_2 - 0.00023 19.8 2.2 4 5.8 0.0 5.4 5 1 1 6 6 6 1 Glycosyl hydrolase family 66 UPA PF17217.1 NM_001306131.1_2 - 0.006 16.5 0.1 5.3 7.0 0.0 4.1 5 0 0 5 5 5 1 UPA domain Cpn60_TCP1 PF00118.22 NM_030752.2_2 - 1.1e-156 522.2 12.2 1.2e-156 522.0 12.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MAGE_N PF12440.6 NM_001321404.1_1 - 3.8e-27 94.7 9.3 6e-27 94.0 9.3 1.3 1 0 0 1 1 1 1 Melanoma associated antigen family N terminal MAGE PF01454.17 NM_001321404.1_1 - 4.5e-19 68.9 0.0 5e-11 42.6 0.0 2.2 1 1 1 2 2 2 2 MAGE family Parathyroid PF01279.15 NM_198966.1_1 - 5.9e-33 113.6 0.6 1.1e-32 112.7 0.6 1.4 1 0 0 1 1 1 1 Parathyroid hormone family PIP5K PF01504.16 NM_024779.4_3 - 8.4e-69 231.7 0.0 1.1e-68 231.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase dCMP_cyt_deam_1 PF00383.21 NM_001785.2_3 - 1.3e-16 60.2 0.4 1.8e-16 59.7 0.4 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.10 NM_001785.2_3 - 3.6e-13 49.8 0.4 9.4e-10 38.7 0.0 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.4 NM_001785.2_3 - 0.073 12.5 0.4 4.5 6.7 0.0 2.2 1 1 1 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases MFAP1 PF06991.9 NM_005926.2_2 - 6.8e-78 261.3 30.1 6.8e-78 261.3 30.1 2.1 2 0 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing Fox-1_C PF12414.6 NM_001031695.2_3 - 1.7e-43 146.7 22.7 3e-43 145.9 22.7 1.4 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 NM_001031695.2_3 - 1.9e-17 62.7 0.1 3.2e-17 62.0 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SWIRM-assoc_2 PF16496.3 NM_003074.3_2 - 3.5e-193 642.0 13.6 3.5e-193 642.0 13.6 2.2 2 0 0 2 2 2 1 SWIRM-associated domain at the N-terminal SWIRM-assoc_1 PF16495.3 NM_003074.3_2 - 2e-31 107.7 17.3 4.7e-31 106.6 17.3 1.7 1 0 0 1 1 1 1 SWIRM-associated region 1 SWIRM-assoc_3 PF16498.3 NM_003074.3_2 - 4.3e-31 106.8 1.4 4.3e-31 106.8 1.4 2.6 2 0 0 2 2 2 1 SWIRM-associated domain at the C-terminal SWIRM PF04433.15 NM_003074.3_2 - 2e-30 104.8 0.1 5.4e-30 103.5 0.1 1.8 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.29 NM_003074.3_2 - 1.4e-11 44.2 0.2 3.1e-11 43.1 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 NM_003074.3_2 - 1.9e-07 31.1 0.0 6.9e-07 29.3 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Chromo PF00385.22 NM_003074.3_2 - 0.037 13.8 0.6 0.11 12.3 0.6 1.8 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain BRCT_2 PF16589.3 NM_003074.3_2 - 0.043 14.1 0.1 0.21 11.9 0.1 2.1 1 1 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain DUF919 PF06034.9 NM_003074.3_2 - 0.055 13.2 4.6 0.15 11.8 4.6 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) HIN PF02760.13 NM_198928.4_2 - 1.2e-72 242.9 2.5 1.8e-72 242.4 2.5 1.3 1 0 0 1 1 1 1 HIN-200/IF120x domain PYRIN PF02758.14 NM_198928.4_2 - 9.1e-12 44.9 0.1 1.7e-11 44.0 0.1 1.5 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain DSPc PF00782.18 NM_007240.2_2 - 2.1e-25 88.9 0.0 2.9e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.10 NM_007240.2_2 - 0.0013 18.9 0.0 0.0023 18.1 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.25 NM_007240.2_2 - 0.028 13.9 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.4 NM_007240.2_2 - 0.17 11.9 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate IL8 PF00048.18 NM_002989.3_3 - 3.1e-23 81.5 0.8 7.3e-23 80.4 0.8 1.7 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like AMOP PF03782.15 NM_182509.3_2 - 2.9e-25 88.9 0.5 2.9e-25 88.9 0.5 1.6 2 0 0 2 2 2 1 AMOP domain TSP_1 PF00090.17 NM_182509.3_2 - 0.00038 20.5 13.1 0.00038 20.5 13.1 2.2 2 0 0 2 2 2 1 Thrombospondin type 1 domain ANF_receptor PF01094.26 NM_001258022.1_1 - 9.8e-70 235.3 0.0 1.3e-69 234.8 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 NM_001258022.1_1 - 3.9e-60 201.9 0.1 6.9e-60 201.1 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_001258022.1_1 - 4.9e-44 149.1 0.0 9.7e-44 148.1 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_001258022.1_1 - 1.2e-22 80.3 0.0 2.3e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 NM_001258022.1_1 - 0.089 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein DUF659 PF04937.13 NM_001258022.1_1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) Ig_3 PF13927.4 NM_001184716.1_2 - 0.01 16.3 0.7 0.028 14.9 0.7 1.8 1 0 0 1 1 1 0 Immunoglobulin domain PKD_3 PF16820.3 NM_001184716.1_2 - 0.058 13.0 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 PKD-like domain OAD_gamma PF04277.11 NM_001184716.1_2 - 0.17 12.3 0.6 0.33 11.4 0.6 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Ank_2 PF12796.5 NM_015574.1_2 - 8.6e-150 487.6 38.6 1.6e-19 70.1 0.9 12.4 3 3 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_015574.1_2 - 6.8e-125 405.9 14.4 5.7e-12 45.8 0.0 16.5 7 4 9 17 17 17 17 Ankyrin repeats (many copies) Ank PF00023.28 NM_015574.1_2 - 3.5e-111 359.1 55.7 6.3e-08 32.6 0.0 24.9 25 0 0 25 25 25 21 Ankyrin repeat Ank_3 PF13606.4 NM_015574.1_2 - 2.8e-101 319.0 32.6 8.3e-05 22.6 0.0 25.5 25 0 0 25 25 25 22 Ankyrin repeat Ank_5 PF13857.4 NM_015574.1_2 - 2.9e-98 320.0 50.0 3.6e-10 39.8 0.0 21.1 7 4 14 21 21 21 21 Ankyrin repeats (many copies) KH_1 PF00013.27 NM_015574.1_2 - 1.6e-15 56.5 2.4 4.2e-15 55.2 2.4 1.8 1 0 0 1 1 1 1 KH domain KH_4 PF13083.4 NM_015574.1_2 - 0.04 13.6 0.0 0.19 11.5 0.0 2.2 1 0 0 1 1 1 0 KH domain Herpes_PAP PF03325.11 NM_015574.1_2 - 0.41 9.6 6.1 0.76 8.7 6.1 1.3 1 0 0 1 1 1 0 Herpesvirus polymerase accessory protein 7tm_1 PF00001.19 NM_002565.3_1 - 3.6e-41 141.0 17.9 6.6e-41 140.2 17.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 NM_002565.3_1 - 0.0071 15.5 0.6 0.043 13.0 0.6 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw RabGAP-TBC PF00566.16 NM_001291465.1_2 - 1.1e-37 129.7 0.0 1.5e-37 129.3 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain 7tm_1 PF00001.19 NM_001277205.1_3 - 5.7e-41 140.4 8.0 9.1e-41 139.7 8.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 NM_001277205.1_3 - 0.0074 15.5 0.1 0.013 14.8 0.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Ras PF00071.20 NM_001254738.1_3 - 6.3e-43 146.0 0.0 8.9e-43 145.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001254738.1_3 - 3.5e-19 69.1 0.0 7.3e-19 68.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001254738.1_3 - 3.5e-06 26.5 0.0 5.5e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SNCAIP_SNCA_bd PF16700.3 NM_001242935.2_3 - 1.9e-24 85.0 7.3 4.7e-24 83.7 7.3 1.7 1 0 0 1 1 1 1 Synphilin-1 alpha-Synuclein-binding domain Ank_2 PF12796.5 NM_001242935.2_3 - 1.8e-09 37.9 0.0 4.6e-09 36.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001242935.2_3 - 9.7e-08 32.3 0.0 0.00021 21.6 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001242935.2_3 - 0.00012 22.2 0.0 0.0012 19.1 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 NM_001242935.2_3 - 0.0025 18.0 0.1 0.0071 16.6 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeat Lzipper-MIP1 PF14389.4 NM_001242935.2_3 - 2.2 8.4 7.5 0.52 10.5 1.7 2.6 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Ion_trans PF00520.29 NM_002977.3_3 - 2.2e-257 848.9 101.0 3.5e-82 275.2 15.8 4.2 4 0 0 4 4 4 4 Ion transport protein Na_trans_cytopl PF11933.6 NM_002977.3_3 - 1e-70 237.8 10.3 1e-70 237.8 10.3 1.7 2 0 0 2 2 2 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.11 NM_002977.3_3 - 3e-55 187.3 2.5 3e-55 187.3 2.5 3.3 4 0 0 4 4 4 1 Sodium ion transport-associated GPHH PF16905.3 NM_002977.3_3 - 1.2e-05 24.8 0.0 2.8e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.10 NM_002977.3_3 - 0.00011 20.9 86.1 0.00012 20.8 0.3 9.5 7 3 2 10 10 10 6 Polycystin cation channel IQ PF00612.25 NM_002977.3_3 - 0.0049 16.4 0.6 0.015 14.9 0.6 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif Lustrin_cystein PF14625.4 NM_002977.3_3 - 0.89 9.9 5.0 0.16 12.3 0.2 2.2 2 0 0 2 2 2 0 Lustrin, cysteine-rich repeated domain ATP-synt_B PF00430.16 NM_002977.3_3 - 7.7 6.5 13.7 1.7 8.6 9.1 2.4 2 1 0 2 2 2 0 ATP synthase B/B' CF(0) TANGO2 PF05742.10 NM_001322163.1_1 - 1.1e-52 179.5 0.0 1.8e-30 106.7 0.0 2.2 1 1 1 2 2 2 2 Transport and Golgi organisation 2 zf-RanBP PF00641.16 NM_001170937.1_1 - 4.7e-12 44.9 9.3 1.2e-11 43.5 9.3 1.8 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.20 NM_001170937.1_1 - 2.3e-10 40.0 0.0 4.8e-10 39.0 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FA_desaturase PF00487.22 NM_206918.2_2 - 6.4e-25 88.3 23.7 6.4e-25 88.3 23.7 2.6 2 1 1 3 3 3 1 Fatty acid desaturase Lipid_DES PF08557.8 NM_206918.2_2 - 9.8e-20 69.6 0.4 1.7e-19 68.9 0.4 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Sperm_Ag_HE2 PF05324.11 NM_001081552.2_3 - 3.9e-34 116.7 1.3 9.4e-34 115.5 1.3 1.7 1 0 0 1 1 1 1 Sperm antigen HE2 Defensin_beta PF00711.17 NM_001081552.2_3 - 0.0064 16.4 3.3 0.0064 16.4 3.3 2.0 2 0 0 2 2 2 1 Beta defensin Fer4_20 PF14691.4 NM_001160301.1_3 - 1.3e-32 111.8 0.1 3e-32 110.6 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Hormone_2 PF00123.18 NM_004123.2_3 - 4.6e-09 36.0 0.1 9.6e-09 34.9 0.1 1.6 1 0 0 1 1 1 1 Peptide hormone BCIP PF13862.4 NM_078468.2_3 - 8.8e-57 192.1 3.2 8.8e-57 192.1 3.2 1.7 2 0 0 2 2 2 1 p21-C-terminal region-binding protein DNA_pol_phi PF04931.11 NM_078468.2_3 - 0.19 9.6 17.0 0.4 8.6 17.0 1.4 1 0 0 1 1 1 0 DNA polymerase phi DUF2722 PF10846.6 NM_078468.2_3 - 1.7 7.4 6.4 2.6 6.8 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FAM176 PF14851.4 NM_078468.2_3 - 6.9 6.2 7.7 4 7.0 4.9 1.9 2 0 0 2 2 2 0 FAM176 family Amidohydro_1 PF01979.18 NM_001014809.2_1 - 1.9e-32 112.8 0.0 2.4e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 NM_001014809.2_1 - 1.3e-09 37.9 0.1 4.8e-07 29.5 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_2 PF04909.12 NM_001014809.2_1 - 0.049 13.3 0.0 0.098 12.3 0.0 1.5 1 0 0 1 1 1 0 Amidohydrolase Y_phosphatase PF00102.25 NM_001042357.4_2 - 5.4e-76 255.1 0.7 6.9e-76 254.8 0.7 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 NM_001042357.4_2 - 0.0029 17.3 0.1 0.0055 16.4 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_001042357.4_2 - 0.0053 16.6 0.0 0.0087 15.9 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_001042357.4_2 - 0.08 12.9 0.0 0.2 11.7 0.0 1.6 2 0 0 2 2 2 0 Inositol hexakisphosphate Collagen PF01391.16 NM_199235.2_1 - 0.00033 20.2 4.8 0.00033 20.2 4.8 3.2 4 0 0 4 4 4 1 Collagen triple helix repeat (20 copies) Lectin_C PF00059.19 NM_199235.2_2 - 4.4e-15 56.2 0.0 7.1e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 NM_199235.2_2 - 1.7e-08 33.9 14.9 1.7e-08 33.9 14.9 1.9 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) Hydrolase_4 PF12146.6 NM_018394.3_1 - 3.8e-10 39.3 0.1 3.1e-06 26.5 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 NM_018394.3_1 - 4.5e-09 36.2 0.1 3.3e-08 33.4 0.1 1.9 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_018394.3_1 - 1e-06 29.4 1.5 1.3e-06 29.1 0.0 1.8 2 1 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.19 NM_018394.3_1 - 4e-05 23.1 0.0 6.2e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Sulfatase PF00884.21 NM_001085427.2_2 - 6.1e-80 268.8 0.0 8.2e-80 268.3 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.4 NM_001085427.2_2 - 5.7e-26 91.5 0.1 9.4e-26 90.8 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.20 NM_001085427.2_2 - 0.00018 21.1 0.1 0.011 15.2 0.0 2.1 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.3 NM_001085427.2_2 - 0.027 14.6 0.0 9.1 6.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4976) DUF1501 PF07394.10 NM_001085427.2_2 - 0.03 13.2 0.1 0.048 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Sel1 PF08238.10 NM_001142603.2_3 - 1.7e-23 82.4 12.8 2.8e-10 40.4 0.1 5.5 5 0 0 5 5 5 4 Sel1 repeat TPR_2 PF07719.15 NM_001142603.2_3 - 0.042 13.8 0.2 14 5.9 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001142603.2_3 - 0.63 9.8 3.3 8.7 6.2 0.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat zf-H2C2_2 PF13465.4 NM_001242895.1_2 - 6e-47 155.9 46.5 4.3e-09 36.3 0.3 10.3 9 1 0 9 9 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001242895.1_2 - 1.8e-41 138.2 58.1 1.4e-06 28.3 1.0 9.3 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001242895.1_2 - 4.3e-18 64.3 67.7 0.0063 17.1 2.2 10.2 10 0 0 10 10 9 8 C2H2-type zinc finger KRAB PF01352.25 NM_001242895.1_2 - 3.7e-08 32.8 0.0 7.2e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001242895.1_2 - 4.4e-07 29.5 47.1 0.087 12.7 0.9 8.5 8 0 0 8 8 8 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001242895.1_2 - 1.8e-06 27.8 32.4 0.0078 16.2 1.3 5.2 2 1 3 5 5 5 5 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001242895.1_2 - 4.2e-06 26.8 31.3 0.15 12.3 0.5 9.1 9 0 0 9 9 9 3 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001242895.1_2 - 0.006 16.5 33.6 3.3 7.7 0.6 7.9 8 0 0 8 8 8 4 XPA protein N-terminal C1_4 PF07975.10 NM_001242895.1_2 - 0.12 12.5 27.1 0.5 10.5 0.3 5.3 2 2 3 5 5 5 0 TFIIH C1-like domain HypA PF01155.17 NM_001242895.1_2 - 0.27 11.1 20.4 0.087 12.7 0.5 4.0 2 1 0 2 2 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 NM_001242895.1_2 - 0.62 10.7 27.3 6.3 7.5 6.8 5.0 1 1 6 7 7 7 0 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_001242895.1_2 - 5.2 6.8 41.4 1.1 8.9 3.6 7.7 8 0 0 8 8 8 0 zinc-finger C2H2-type UT PF03253.12 NM_001146036.2_2 - 1.3e-109 365.8 31.4 1.7e-109 365.3 31.4 1.2 1 0 0 1 1 1 1 Urea transporter Abhydrolase_1 PF00561.18 NM_021160.2_2 - 7.1e-10 38.8 0.3 2.4e-09 37.1 0.3 1.7 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 NM_021160.2_2 - 2.2e-05 23.7 0.0 4e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.5 NM_021160.2_2 - 0.021 15.3 2.9 0.17 12.4 0.1 2.8 2 1 1 3 3 3 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.19 NM_021160.2_2 - 0.14 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ephrin PF00812.15 NM_005227.2_1 - 2.3e-37 127.9 0.0 3.8e-37 127.2 0.0 1.3 1 0 0 1 1 1 1 Ephrin CitMHS PF03600.14 NM_001300984.1_3 - 8.3e-53 179.4 14.5 8.3e-53 179.4 14.5 2.2 2 1 1 3 3 3 2 Citrate transporter Na_sulph_symp PF00939.17 NM_001300984.1_3 - 3.4e-16 59.2 29.7 2.3e-10 40.0 11.4 2.1 2 0 0 2 2 2 2 Sodium:sulfate symporter transmembrane region ArsB PF02040.13 NM_001300984.1_3 - 4e-09 36.2 15.6 0.00018 20.9 4.9 2.2 2 0 0 2 2 2 2 Arsenical pump membrane protein MatC_N PF07158.9 NM_001300984.1_3 - 0.00061 19.7 5.5 0.00061 19.7 5.5 2.5 2 0 0 2 2 2 1 Dicarboxylate carrier protein MatC N-terminus MIP PF00230.18 NM_001318158.1_1 - 0.33 10.5 1.4 0.46 10.0 1.4 1.1 1 0 0 1 1 1 0 Major intrinsic protein MIP PF00230.18 NM_001318158.1_3 - 1.5e-44 152.3 4.9 1.9e-44 151.9 4.9 1.1 1 0 0 1 1 1 1 Major intrinsic protein PNTB PF02233.14 NM_001318158.1_3 - 0.61 8.8 5.7 0.078 11.7 0.8 1.7 2 0 0 2 2 2 0 NAD(P) transhydrogenase beta subunit Dynein_attach_N PF15867.3 NM_213607.2_2 - 9.8e-29 99.0 0.1 1.6e-28 98.3 0.1 1.4 1 0 0 1 1 1 1 Dynein attachment factor N-terminus RPAP3_C PF13877.4 NM_213607.2_2 - 4.3e-13 49.5 0.0 8e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 BEX PF04538.10 NM_018476.3_1 - 6.5e-20 71.9 14.3 1.3e-19 70.9 14.3 1.5 1 1 0 1 1 1 1 Brain expressed X-linked like family His_Phos_2 PF00328.20 NM_001302492.1_2 - 1.1e-19 70.9 0.3 2.7e-16 59.8 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) His_Phos_2 PF00328.20 NM_001302492.1_3 - 8.2e-08 31.9 0.1 1.1e-07 31.4 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) IL8 PF00048.18 NM_001178134.1_3 - 2e-06 27.7 1.4 2e-06 27.7 1.4 1.8 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like CPSase_L_D2 PF02786.15 NM_001178004.1_2 - 2.7e-86 288.3 0.0 4.9e-86 287.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.20 NM_001178004.1_2 - 3e-46 156.4 0.5 1.1e-45 154.6 0.2 2.0 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.17 NM_001178004.1_2 - 6.4e-36 122.6 0.0 1.4e-35 121.6 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.20 NM_001178004.1_2 - 3.5e-14 52.2 3.5 4.1e-14 52.0 0.9 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.11 NM_001178004.1_2 - 3.9e-10 39.5 0.1 4.5e-09 36.0 0.0 2.2 1 1 1 2 2 2 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.4 NM_001178004.1_2 - 1.9e-09 36.6 0.1 5.1e-09 35.1 0.1 1.7 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.20 NM_001178004.1_2 - 1.1e-06 28.2 0.0 2.1e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.9 NM_001178004.1_2 - 3.4e-05 23.4 0.0 5.8e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.12 NM_001178004.1_2 - 0.0013 18.7 0.0 0.0028 17.6 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.4 NM_001178004.1_2 - 0.0099 15.2 0.0 0.045 13.1 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain SLT_beta PF02258.14 NM_001178004.1_2 - 0.035 14.0 0.1 0.035 14.0 0.1 3.1 4 0 0 4 4 4 0 Shiga-like toxin beta subunit Biotin_lipoyl_2 PF13533.4 NM_001178004.1_2 - 0.079 12.7 0.5 0.19 11.5 0.0 2.0 2 1 0 2 2 1 0 Biotin-lipoyl like GARS_A PF01071.17 NM_001178004.1_2 - 0.094 12.3 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain SnoaL_3 PF13474.4 NM_001178004.1_2 - 0.11 12.6 0.1 1.9 8.6 0.0 2.7 2 1 1 3 3 3 0 SnoaL-like domain BAH PF01426.16 NM_001291324.1_2 - 1.2e-15 57.3 0.0 2.2e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 BAH domain DUF4537 PF15057.4 NM_001291324.1_2 - 0.011 15.6 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) DUF2090 PF09863.7 NM_001291324.1_2 - 0.02 13.8 0.1 0.031 13.2 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2090) COE1_DBD PF16422.3 NM_001324101.1_3 - 3.2e-146 484.6 1.2 4.4e-146 484.2 1.2 1.2 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.3 NM_001324101.1_3 - 1.6e-35 120.4 3.0 2e-29 100.9 0.4 2.4 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.22 NM_001324101.1_3 - 8.9e-12 44.8 0.3 2.1e-11 43.6 0.3 1.7 1 0 0 1 1 1 1 IPT/TIG domain Glycophorin_A PF01102.16 NM_207352.3_1 - 0.24 11.5 0.8 0.42 10.7 0.8 1.3 1 0 0 1 1 1 0 Glycophorin A p450 PF00067.20 NM_207352.3_2 - 6.5e-120 400.9 0.0 8.1e-120 400.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Synaphin PF05835.10 NM_006651.3_3 - 8.3e-40 136.2 13.2 8.3e-40 136.2 13.2 1.5 2 0 0 2 2 2 1 Synaphin protein Aldo_ket_red PF00248.19 NM_001199861.1_1 - 1.5e-72 244.1 0.0 1.8e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family zf-C2H2_6 PF13912.4 NM_183231.2_3 - 0.85 9.5 5.4 1 9.3 0.4 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger ArfGap PF01412.16 NM_018209.3_3 - 4.2e-32 110.5 0.2 4.2e-32 110.5 0.2 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf WW PF00397.24 NM_015472.4_2 - 1.5e-07 31.1 0.1 3.3e-07 30.0 0.1 1.6 1 0 0 1 1 1 1 WW domain SH3_9 PF14604.4 NM_001286678.1_1 - 2.5e-10 39.9 0.0 6.5e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001286678.1_1 - 5.3e-10 38.6 0.0 9e-10 37.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001286678.1_1 - 1e-08 34.6 0.0 2.4e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain MTS PF05175.12 NM_001286678.1_1 - 4e-07 29.6 0.0 5.9e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.4 NM_001286678.1_1 - 1.5e-05 25.4 0.1 2.5e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.11 NM_001286678.1_1 - 3.2e-05 23.3 0.0 4.6e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.10 NM_001286678.1_1 - 0.00038 20.9 0.1 0.00068 20.1 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001286678.1_1 - 0.0018 18.0 0.0 0.0025 17.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.14 NM_001286678.1_1 - 0.0019 17.8 0.0 0.0029 17.3 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.4 NM_001286678.1_1 - 0.0028 17.5 0.0 0.0051 16.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.5 NM_001286678.1_1 - 0.012 15.4 0.1 0.019 14.8 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.12 NM_001286678.1_1 - 0.022 14.1 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_24 PF13578.4 NM_001286678.1_1 - 0.025 15.5 0.0 0.05 14.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.14 NM_001286678.1_1 - 0.077 11.9 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase CAF1 PF04857.18 NM_001286678.1_1 - 0.14 11.2 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease zf-H2C2_2 PF13465.4 NM_001317116.1_3 - 9.5e-87 281.7 104.5 2.2e-08 34.0 2.1 13.8 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001317116.1_3 - 1.3e-44 148.0 94.9 5.9e-05 23.2 1.1 13.5 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_001317116.1_3 - 2.2e-25 87.9 93.7 0.00095 18.9 0.5 13.4 13 0 0 13 13 12 11 C2H2-type zinc finger KRAB PF01352.25 NM_001317116.1_3 - 4e-25 87.1 0.9 7e-25 86.3 0.9 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001317116.1_3 - 2.5e-22 77.5 98.1 0.0035 17.9 0.8 14.0 13 0 0 13 13 12 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001317116.1_3 - 1.3e-14 53.9 61.2 0.002 18.1 1.0 7.7 6 2 0 6 6 6 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001317116.1_3 - 4.5e-07 29.9 61.8 0.34 11.2 1.0 12.4 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001317116.1_3 - 0.19 12.3 52.6 0.6 10.8 1.3 7.1 2 1 6 8 8 8 0 zinc-ribbon family zf-trcl PF13451.4 NM_001317116.1_3 - 0.27 11.0 58.2 4.5 7.1 0.1 11.5 10 2 0 10 10 10 0 Probable zinc-ribbon domain C1_4 PF07975.10 NM_001317116.1_3 - 0.46 10.7 51.9 0.84 9.8 1.5 8.3 2 2 7 9 9 9 0 TFIIH C1-like domain XPA_N PF01286.16 NM_001317116.1_3 - 3.1 7.8 58.9 8 6.5 0.0 12.2 12 0 0 12 12 12 0 XPA protein N-terminal 7tm_1 PF00001.19 NM_001278000.1_3 - 7.8e-47 159.6 26.1 1.4e-46 158.8 26.1 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001278000.1_3 - 7.9e-08 31.8 27.9 1.2e-07 31.3 27.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx EF-hand_7 PF13499.4 NM_001623.4_2 - 0.00032 21.0 0.0 0.00052 20.3 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_001623.4_2 - 0.002 17.8 0.3 0.0053 16.5 0.3 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.30 NM_001623.4_2 - 0.038 13.4 0.7 0.038 13.4 0.7 1.8 2 0 0 2 2 2 0 EF hand DUF21 PF01595.18 NM_020184.3_3 - 2.6e-34 118.3 0.9 4.3e-34 117.6 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.26 NM_020184.3_3 - 5.8e-08 32.9 0.4 0.0014 18.9 0.0 3.1 3 0 0 3 3 3 2 CBS domain cNMP_binding PF00027.27 NM_020184.3_3 - 0.0022 17.8 0.0 0.0079 16.1 0.0 1.9 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Rib_recp_KP_reg PF05104.10 NM_004587.2_2 - 7.3e-32 111.4 31.5 7.3e-32 111.4 31.5 6.7 4 3 2 6 6 6 1 Ribosome receptor lysine/proline rich region IncA PF04156.12 NM_004587.2_2 - 0.0056 16.4 17.5 0.0056 16.4 17.5 8.4 3 2 5 8 8 8 5 IncA protein ABC_export PF16962.3 NM_004587.2_2 - 0.3 9.3 0.7 0.45 8.8 0.7 1.2 1 0 0 1 1 1 0 Putative ABC exporter Pkinase PF00069.23 NM_001256690.1_3 - 1e-50 172.4 0.0 1.7e-50 171.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001256690.1_3 - 1.6e-24 86.5 0.0 2.8e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 NM_001256690.1_3 - 2.1e-14 52.9 0.2 4.7e-14 51.8 0.2 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.4 NM_001256690.1_3 - 1.9e-08 33.9 0.0 2.8e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001256690.1_3 - 4.1e-05 22.9 0.0 7.8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001256690.1_3 - 0.025 14.4 0.1 0.052 13.3 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.18 NM_001256690.1_3 - 0.057 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase C2 PF00168.28 NM_001129896.2_3 - 7.2e-41 138.5 0.0 3.2e-19 69.0 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 NM_001129896.2_3 - 6e-22 77.9 9.6 1.8e-21 76.4 9.6 1.8 1 0 0 1 1 1 1 FYVE-type zinc finger AreA_N PF07573.9 NM_001129896.2_3 - 0.016 15.7 0.3 0.035 14.6 0.3 1.5 1 0 0 1 1 1 0 Nitrogen regulatory protein AreA N terminus MHC_I PF00129.16 NM_002116.7_1 - 7e-95 315.5 0.9 9.9e-95 315.0 0.9 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_002116.7_1 - 3.8e-17 62.4 0.0 8.9e-17 61.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 NM_002116.7_1 - 1.3e-16 60.0 8.1 2.4e-16 59.2 8.1 1.4 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 NM_002116.7_1 - 0.00085 19.2 0.1 0.0025 17.7 0.1 1.8 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain MHC_I_3 PF16497.3 NM_002116.7_1 - 0.0019 17.6 0.0 0.0027 17.1 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain ig PF00047.23 NM_002116.7_1 - 0.006 16.6 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain DUF202 PF02656.13 NM_002116.7_1 - 0.052 13.9 0.4 12 6.3 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) TPD52 PF04201.13 NM_001025253.2_1 - 1.5e-73 245.6 7.2 2.4e-73 244.9 7.2 1.3 1 0 0 1 1 1 1 Tumour protein D52 family IncA PF04156.12 NM_001025253.2_1 - 0.027 14.1 4.1 0.043 13.5 4.1 1.2 1 0 0 1 1 1 0 IncA protein Uds1 PF15456.4 NM_001025253.2_1 - 0.1 12.7 6.3 0.18 11.9 6.3 1.3 1 0 0 1 1 1 0 Up-regulated During Septation Spc7 PF08317.9 NM_001025253.2_1 - 0.22 10.2 6.0 0.33 9.6 6.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Cnn_1N PF07989.9 NM_001025253.2_1 - 0.3 11.1 4.5 0.62 10.1 4.5 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 TBPIP PF07106.11 NM_001025253.2_1 - 1.5 8.5 6.9 0.88 9.2 4.8 1.6 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) OmpH PF03938.12 NM_001025253.2_1 - 5.3 6.9 7.9 10 5.9 7.9 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HAGH_C PF16123.3 NM_005326.4_3 - 2.1e-26 92.1 0.2 3.5e-26 91.4 0.2 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 NM_005326.4_3 - 4.8e-12 46.2 2.9 2.3e-07 30.9 1.1 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 NM_005326.4_3 - 0.0021 17.4 0.4 0.0056 16.1 0.4 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Cpn60_TCP1 PF00118.22 NM_001193529.2_3 - 7.4e-141 470.0 12.7 2.9e-90 303.1 2.6 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family GST_C_3 PF14497.4 NM_001193529.2_3 - 0.1 12.7 0.3 0.2 11.8 0.3 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Homeobox PF00046.27 NM_145657.2_1 - 4e-22 77.7 4.4 5.7e-22 77.2 4.4 1.2 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_145657.2_1 - 0.06 13.1 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 Homeobox KN domain Terminase_5 PF06056.10 NM_145657.2_1 - 0.071 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Ada3 PF10198.7 NM_145657.2_1 - 0.1 12.6 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 HTH_23 PF13384.4 NM_145657.2_1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Cullin_binding PF03556.13 NM_001318741.1_1 - 6.8e-28 97.4 4.4 1.2e-27 96.6 4.4 1.4 1 0 0 1 1 1 1 Cullin binding EGF_CA PF07645.13 NM_001321431.1_3 - 0 1054.0 636.3 6.7e-11 42.1 3.3 47.0 45 2 2 47 47 47 43 Calcium-binding EGF domain cEGF PF12662.5 NM_001321431.1_3 - 1.3e-200 648.3 383.0 9.3e-09 34.9 1.0 48.7 49 0 0 49 49 49 43 Complement Clr-like EGF-like TB PF00683.15 NM_001321431.1_3 - 2.2e-100 328.0 130.7 1.5e-13 50.0 6.6 11.4 9 0 0 9 9 9 9 TB domain EGF PF00008.25 NM_001321431.1_3 - 2.5e-92 302.5 652.0 0.00081 19.5 5.3 47.8 46 1 0 46 46 46 42 EGF-like domain FXa_inhibition PF14670.4 NM_001321431.1_3 - 4.2e-90 295.6 686.3 1.1e-08 35.1 9.9 47.7 43 4 4 47 47 47 43 Coagulation Factor Xa inhibitory site hEGF PF12661.5 NM_001321431.1_3 - 1.2e-65 216.0 654.5 0.00029 21.2 3.0 51.6 51 0 0 51 51 51 40 Human growth factor-like EGF EGF_3 PF12947.5 NM_001321431.1_3 - 4.7e-54 180.2 542.1 6e-09 35.8 4.3 47.7 42 4 3 45 45 45 36 EGF domain EGF_MSP1_1 PF12946.5 NM_001321431.1_3 - 0.00042 20.2 18.5 0.00047 20.0 4.9 40.9 41 2 2 43 43 43 9 MSP1 EGF domain 1 Mob1_phocein PF03637.15 NM_001317112.1_3 - 8.7e-46 155.9 0.0 1.9e-45 154.8 0.0 1.5 1 0 0 1 1 1 1 Mob1/phocein family Laminin_G_2 PF02210.22 NM_130773.3_2 - 3.9e-90 298.8 5.6 1e-24 87.4 0.2 4.3 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.21 NM_130773.3_2 - 1e-61 206.7 0.2 4.1e-15 56.0 0.0 4.3 4 0 0 4 4 4 4 Laminin G domain F5_F8_type_C PF00754.23 NM_130773.3_2 - 6e-29 100.6 2.9 1.1e-28 99.7 1.5 2.2 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_3 PF13385.4 NM_130773.3_2 - 1.2e-08 35.1 0.0 0.0025 17.8 0.0 5.0 5 0 0 5 5 5 1 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 NM_130773.3_2 - 0.00068 19.7 26.0 0.0019 18.3 9.7 3.3 3 0 0 3 3 3 2 EGF-like domain EGF_2 PF07974.11 NM_130773.3_2 - 0.0085 16.3 11.3 0.0085 16.3 11.3 3.7 3 0 0 3 3 3 1 EGF-like domain Pkinase PF00069.23 NM_001256630.1_2 - 2.7e-67 226.8 0.0 4e-67 226.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001256630.1_2 - 2.7e-36 125.1 0.0 3.8e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_001256630.1_2 - 0.00017 21.5 0.4 0.002 18.0 0.0 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_001256630.1_2 - 0.017 14.3 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.18 NM_001256630.1_2 - 0.038 13.4 0.1 0.067 12.6 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.12 NM_001256630.1_2 - 0.069 12.4 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C2H2 PF00096.24 NM_001317940.1_2 - 6.5e-07 29.3 32.8 0.018 15.4 1.8 7.4 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-met PF12874.5 NM_001317940.1_2 - 0.0002 21.5 22.0 0.027 14.7 0.1 5.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001317940.1_2 - 0.021 15.0 16.5 1.7 8.9 1.5 4.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Syndecan PF01034.18 NM_014654.3_3 - 2.5e-26 91.2 0.2 4e-26 90.6 0.2 1.3 1 0 0 1 1 1 1 Syndecan domain Pkinase PF00069.23 NM_014683.3_3 - 2.2e-68 230.4 0.0 3e-68 229.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_014683.3_3 - 3e-48 164.3 0.0 4.4e-48 163.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.6 NM_014683.3_3 - 4.7e-24 85.0 3.1 7.6e-24 84.3 3.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Kdo PF06293.12 NM_014683.3_3 - 7.4e-07 28.6 0.1 1.3e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 NM_014683.3_3 - 6.2e-05 22.5 0.0 0.00011 21.8 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.4 NM_014683.3_3 - 0.034 13.3 0.0 0.079 12.1 0.0 1.5 1 1 0 1 1 1 0 Kinase-like APH PF01636.21 NM_014683.3_3 - 0.1 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-H2C2_2 PF13465.4 NM_194325.2_1 - 9.1e-128 411.4 127.9 5.4e-09 36.0 0.3 18.8 18 1 0 18 18 18 17 Zinc-finger double domain zf-C2H2 PF00096.24 NM_194325.2_1 - 4.5e-84 272.3 113.4 6e-06 26.3 3.0 18.3 18 0 0 18 18 18 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_194325.2_1 - 2.1e-44 146.1 113.6 0.0011 19.5 2.5 18.2 18 0 0 18 18 18 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_194325.2_1 - 9.3e-29 98.7 103.9 0.0018 18.0 1.9 17.4 17 0 0 17 17 17 14 C2H2-type zinc finger KRAB PF01352.25 NM_194325.2_1 - 1.2e-24 85.6 0.2 2.1e-24 84.8 0.2 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_194325.2_1 - 4.6e-24 84.0 54.1 0.031 14.4 0.1 16.2 16 0 0 16 16 16 9 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_194325.2_1 - 3.6e-17 62.0 77.9 0.81 9.6 0.1 17.4 18 0 0 18 18 18 9 XPA protein N-terminal Zn-ribbon_8 PF09723.8 NM_194325.2_1 - 2.3e-15 56.3 96.1 0.011 15.7 3.7 12.2 3 3 13 17 17 17 12 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_194325.2_1 - 4.1e-05 24.1 67.5 0.44 11.2 1.7 9.4 3 2 6 10 10 10 6 zinc-ribbon family zf-AN1 PF01428.14 NM_194325.2_1 - 0.0026 17.8 82.6 5.7 7.1 0.4 16.3 14 2 2 16 16 16 2 AN1-like Zinc finger zf-C2H2_11 PF16622.3 NM_194325.2_1 - 0.004 16.8 84.3 0.2 11.3 0.1 16.7 18 0 0 18 18 18 5 zinc-finger C2H2-type C1_4 PF07975.10 NM_194325.2_1 - 0.013 15.6 68.6 0.42 10.8 1.0 11.5 2 2 12 14 14 14 0 TFIIH C1-like domain DUF3268 PF11672.6 NM_194325.2_1 - 0.033 14.4 1.1 0.033 14.4 1.1 9.0 4 2 6 12 12 12 0 zinc-finger-containing domain zf-trcl PF13451.4 NM_194325.2_1 - 0.27 11.0 78.3 3.5 7.4 0.1 16.0 15 2 0 16 16 15 0 Probable zinc-ribbon domain CpXC PF14353.4 NM_194325.2_1 - 0.79 9.6 57.9 19 5.2 1.3 14.3 4 3 9 14 14 14 0 CpXC protein ABC2_membrane PF01061.22 NM_207629.1_2 - 9.7e-47 159.0 25.5 1.5e-46 158.3 25.5 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.25 NM_207629.1_2 - 6.6e-28 97.8 0.0 1e-27 97.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 NM_207629.1_2 - 4.9e-06 26.0 0.1 6.6e-05 22.3 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 NM_207629.1_2 - 2.7e-05 24.0 0.0 0.066 12.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 NM_207629.1_2 - 0.0002 21.1 0.0 0.00035 20.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 NM_207629.1_2 - 0.0039 16.8 0.3 0.0085 15.7 0.3 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.4 NM_207629.1_2 - 0.012 15.8 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.21 NM_207629.1_2 - 0.019 14.9 0.1 0.033 14.1 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_13 PF13166.4 NM_207629.1_2 - 0.023 13.2 0.0 0.17 10.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain cobW PF02492.17 NM_207629.1_2 - 0.04 13.4 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.4 NM_207629.1_2 - 0.075 13.4 0.5 0.12 12.7 0.5 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.4 NM_207629.1_2 - 0.076 13.1 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.4 NM_207629.1_2 - 0.09 13.2 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.4 NM_207629.1_2 - 0.1 12.7 0.1 0.31 11.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.4 NM_207629.1_2 - 0.13 11.8 0.2 0.25 10.9 0.2 1.4 1 0 0 1 1 1 0 AAA domain DUF1440 PF07274.10 NM_207629.1_2 - 1.1 9.5 4.8 7.8 6.7 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1440) DUF1126 PF06565.10 NM_025184.3_1 - 4.7e-96 315.4 3.3 2e-29 101.3 0.3 4.3 3 1 1 4 4 4 4 DUF1126 PH-like domain EF-hand_6 PF13405.4 NM_025184.3_1 - 0.027 14.3 0.8 0.66 9.9 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain EF-hand_1 PF00036.30 NM_025184.3_1 - 0.085 12.3 0.6 0.49 9.9 0.0 2.7 2 0 0 2 2 2 0 EF hand TPR_2 PF07719.15 NM_001256068.1_1 - 1.9e-09 36.8 2.1 0.0029 17.5 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat PB1 PF00564.22 NM_001256068.1_1 - 3.4e-09 36.4 0.0 5.9e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 PB1 domain TPR_7 PF13176.4 NM_001256068.1_1 - 1.1e-07 31.2 1.0 0.034 14.1 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001256068.1_1 - 1.8e-07 30.6 0.0 0.052 13.3 0.0 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat SH3_1 PF00018.26 NM_001256068.1_1 - 1e-06 28.1 0.0 2.1e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001256068.1_1 - 1.3e-05 24.7 0.0 2.5e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_001256068.1_1 - 0.00013 21.6 0.0 0.00038 20.1 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain TPR_12 PF13424.4 NM_001256068.1_1 - 0.00018 21.6 2.0 2.4 8.4 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001256068.1_1 - 0.0016 18.4 6.8 3.1 7.9 0.3 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001256068.1_1 - 0.0025 18.3 3.0 0.39 11.3 0.4 4.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001256068.1_1 - 0.0076 16.7 0.0 9 7.0 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001256068.1_1 - 0.0081 16.2 0.0 0.19 11.9 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001256068.1_1 - 0.011 15.4 1.1 2.9 7.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.12 NM_001256068.1_1 - 0.14 12.8 7.7 0.98 10.1 0.5 3.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Ribosomal_L7Ae PF01248.24 NM_006705.3_3 - 2.1e-10 40.1 0.0 3.4e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ig_3 PF13927.4 NM_001256502.1_3 - 1.3e-30 105.7 0.4 3.6e-11 43.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_001256502.1_3 - 1.5e-26 92.2 0.0 1.3e-09 37.8 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 NM_001256502.1_3 - 1.7e-25 88.9 0.3 5.6e-07 29.5 0.2 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_001256502.1_3 - 4.4e-23 81.3 0.1 6.6e-08 32.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.10 NM_001256502.1_3 - 1.1e-14 54.1 0.0 1e-13 51.0 0.0 2.4 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 NM_001256502.1_3 - 2.1e-13 50.3 0.2 2.5e-08 33.9 0.2 3.6 3 0 0 3 3 3 2 Immunoglobulin V-set domain C1-set PF07654.13 NM_001256502.1_3 - 3.4e-08 33.7 0.0 9.4e-07 29.1 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Hydrolase_4 PF12146.6 NM_021214.1_3 - 9.5e-13 47.8 0.0 2.7e-06 26.7 0.0 2.9 3 0 0 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 NM_021214.1_3 - 3.7e-07 29.9 0.0 0.062 12.8 0.0 3.1 2 1 1 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_021214.1_3 - 4.5e-07 30.6 0.2 0.003 18.1 0.0 3.2 2 1 1 3 3 3 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.19 NM_021214.1_3 - 7.5e-06 25.4 0.0 0.00013 21.3 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.16 NM_021214.1_3 - 0.0017 17.8 0.0 0.0073 15.8 0.0 1.8 2 0 0 2 2 2 1 Dienelactone hydrolase family UPF0227 PF05728.10 NM_021214.1_3 - 0.0071 16.2 0.0 0.049 13.4 0.0 2.0 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) DUF818 PF05677.10 NM_021214.1_3 - 0.0073 15.2 0.1 0.011 14.6 0.1 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_5 PF12695.5 NM_021214.1_3 - 0.011 15.3 0.0 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family FSH1 PF03959.11 NM_021214.1_3 - 0.019 14.5 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.14 NM_021214.1_3 - 0.065 12.9 0.0 0.26 10.9 0.0 1.9 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Asp2 PF16929.3 NM_021214.1_3 - 0.066 12.1 0.0 0.096 11.6 0.0 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter BTB PF00651.29 NM_206866.2_1 - 2.7e-24 85.4 0.2 4.7e-24 84.6 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain bZIP_Maf PF03131.15 NM_206866.2_1 - 5.7e-15 55.5 4.0 1.3e-14 54.3 4.0 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.19 NM_206866.2_1 - 1e-09 38.2 6.1 1.9e-09 37.3 6.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_206866.2_1 - 2.2e-07 30.7 6.0 4.9e-07 29.6 6.0 1.5 1 0 0 1 1 1 1 Basic region leucine zipper Cep57_CLD_2 PF14197.4 NM_206866.2_1 - 0.022 14.7 1.3 0.047 13.7 1.3 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Flt3_lig PF02947.12 NM_001204502.1_3 - 6.1e-67 223.6 0.8 7.8e-67 223.3 0.8 1.1 1 0 0 1 1 1 1 flt3 ligand NUFIP1 PF10453.7 NM_012345.2_1 - 1.5e-20 72.7 6.6 3.2e-20 71.6 6.6 1.6 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-C2H2_jaz PF12171.6 NM_012345.2_1 - 0.00016 21.8 3.8 0.00043 20.4 3.8 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.24 NM_012345.2_1 - 0.01 16.1 1.5 0.01 16.1 1.5 2.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type RRM_1 PF00076.20 NM_001308036.1_3 - 3.9e-16 58.5 0.0 6.6e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pribosyltran PF00156.25 NM_020200.6_1 - 8.9e-23 80.4 0.0 1.7e-22 79.5 0.0 1.4 2 0 0 2 2 2 1 Phosphoribosyl transferase domain Homeobox PF00046.27 NM_024014.3_2 - 1.9e-21 75.5 8.8 2.9e-21 74.9 8.8 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_024014.3_2 - 1.9 8.3 4.7 0.86 9.4 1.6 2.0 3 0 0 3 3 3 0 Homeobox KN domain UPF0258 PF06789.10 NM_001257308.1_1 - 9.2e-41 139.6 0.1 1.4e-40 139.0 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0258) 7tm_4 PF13853.4 NM_001005495.1_1 - 3.1e-44 151.7 19.4 3.8e-44 151.4 19.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005495.1_1 - 1.8e-25 89.6 19.6 3.8e-25 88.5 19.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001005495.1_1 - 1.3e-06 27.9 17.7 2.2e-06 27.1 17.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Laminin_EGF PF00053.22 NM_003693.3_3 - 2.4e-14 53.0 174.4 0.00034 20.6 7.2 10.6 6 1 5 11 11 11 7 Laminin EGF domain EGF_2 PF07974.11 NM_003693.3_3 - 5.9e-05 23.2 22.2 0.00042 20.5 7.4 12.9 8 4 4 12 12 12 6 EGF-like domain Bradykinin PF06753.10 NM_003693.3_3 - 5.4 6.7 6.7 0.61 9.7 1.1 2.5 2 0 0 2 2 2 0 Bradykinin Shisa PF13908.4 NM_001272082.1_2 - 1.9e-27 96.6 0.9 4.2e-27 95.5 0.9 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Rad51 PF08423.9 NM_001321814.1_3 - 1.9e-50 171.3 0.0 3e-50 170.8 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 NM_001321814.1_3 - 1.7e-09 37.4 0.0 2.6e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.13 NM_001321814.1_3 - 6e-07 28.9 0.3 2.4e-06 26.9 0.3 1.8 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.11 NM_001321814.1_3 - 7.5e-07 28.6 0.1 1.4e-06 27.7 0.1 1.4 1 1 0 1 1 1 1 KaiC RecA PF00154.19 NM_001321814.1_3 - 2.9e-05 23.5 0.7 0.00026 20.4 0.7 1.9 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_24 PF13479.4 NM_001321814.1_3 - 0.0071 15.9 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain FAD_binding_7 PF03441.12 NM_001127457.2_1 - 1.3e-67 226.9 0.2 1.9e-67 226.4 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.16 NM_001127457.2_1 - 5.5e-28 97.9 0.0 1.1e-27 96.9 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase Peripla_BP_6 PF13458.4 NM_001127457.2_1 - 0.021 14.4 0.0 0.033 13.8 0.0 1.1 1 0 0 1 1 1 0 Periplasmic binding protein Neuregulin PF02158.13 NM_001322205.1_3 - 1.3e-189 630.6 21.4 1.8e-189 630.1 21.4 1.2 1 0 0 1 1 1 1 Neuregulin family EGF PF00008.25 NM_001322205.1_3 - 0.0027 17.9 2.9 0.007 16.5 2.9 1.8 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.11 NM_001322205.1_3 - 1.6 9.0 4.9 4.8 7.5 4.9 1.9 1 0 0 1 1 1 0 EGF-like domain DAGK_acc PF00609.17 NM_001080744.1_1 - 3.7e-57 193.0 0.0 5.7e-57 192.4 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAG_kinase_N PF14513.4 NM_001080744.1_1 - 8.8e-53 178.8 0.1 1.4e-52 178.1 0.1 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus DAGK_cat PF00781.22 NM_001080744.1_1 - 1.3e-18 66.7 0.4 4.6e-16 58.5 0.1 2.4 1 1 1 2 2 2 2 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 NM_001080744.1_1 - 8e-14 51.1 33.6 1.7e-09 37.3 11.2 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.30 NM_001080744.1_1 - 1.2e-07 30.6 1.0 0.0071 15.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 NM_001080744.1_1 - 6e-07 29.7 0.3 1.2e-06 28.7 0.3 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_001080744.1_1 - 7.2e-05 22.3 0.1 0.21 11.5 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 NM_001080744.1_1 - 0.0066 15.8 0.4 0.09 12.2 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 NM_001080744.1_1 - 0.18 11.5 0.3 4 7.1 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair YL1_C PF08265.9 NM_194281.3_1 - 5.2e-10 38.8 0.0 1.5e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DUF5077 PF16871.3 NM_194281.3_1 - 0.056 13.2 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5077) zf-H2C2_2 PF13465.4 NM_024804.2_3 - 4.9e-56 184.7 75.2 9e-09 35.3 1.9 10.6 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_024804.2_3 - 1.4e-34 116.5 87.1 1.4e-05 25.1 3.7 10.3 10 0 0 10 10 10 9 Zinc finger, C2H2 type KRAB PF01352.25 NM_024804.2_3 - 6.8e-25 86.3 0.4 1.1e-24 85.7 0.4 1.3 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_024804.2_3 - 1.6e-24 84.3 84.6 0.0012 19.4 0.4 10.1 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_024804.2_3 - 1.1e-13 50.6 59.8 0.00054 19.7 2.7 9.7 9 0 0 9 9 9 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_024804.2_3 - 0.00022 21.2 58.0 0.044 13.8 3.5 8.2 5 3 4 9 9 9 7 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_024804.2_3 - 0.083 12.5 0.1 0.083 12.5 0.1 9.3 9 0 0 9 9 9 0 zinc-finger C2H2-type C1_4 PF07975.10 NM_024804.2_3 - 0.34 11.1 46.7 0.12 12.5 2.3 6.8 1 1 3 6 6 6 0 TFIIH C1-like domain Bromodomain PF00439.23 NM_001281780.2_1 - 9.3e-16 57.5 0.0 1.6e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Bromodomain PHD PF00628.27 NM_001281780.2_1 - 4.5e-07 29.5 12.9 1.6e-06 27.7 12.9 2.0 1 0 0 1 1 1 1 PHD-finger DUF3544 PF12064.6 NM_001281780.2_3 - 2.6e-102 341.3 19.4 2.6e-102 341.3 19.4 4.0 3 2 1 4 4 4 1 Domain of unknown function (DUF3544) PWWP PF00855.15 NM_001281780.2_3 - 4.2e-07 30.2 0.4 1.9e-06 28.1 0.4 2.3 1 0 0 1 1 1 1 PWWP domain zf-MYND PF01753.16 NM_001281780.2_3 - 0.0025 17.7 17.1 0.0025 17.7 17.1 2.4 2 0 0 2 2 2 1 MYND finger DUF1640 PF07798.9 NM_001281780.2_3 - 0.0053 16.7 6.9 0.0053 16.7 6.9 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1640) Homeobox PF00046.27 NM_033400.2_3 - 1.8e-48 162.0 11.9 1.5e-15 56.6 0.2 3.6 3 0 0 3 3 3 3 Homeobox domain Homeobox_KN PF05920.9 NM_033400.2_3 - 2.6e-08 33.5 0.0 0.2 11.5 0.0 3.9 3 0 0 3 3 3 3 Homeobox KN domain zf-C2H2_2 PF12756.5 NM_033400.2_3 - 1.6e-05 25.0 72.8 0.5 10.6 1.4 14.7 15 1 1 16 16 16 6 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.4 NM_033400.2_3 - 0.00016 21.2 1.6 0.00016 21.2 1.6 9.1 11 0 0 11 11 11 4 C2H2-type zinc-finger domain zf-met PF12874.5 NM_033400.2_3 - 0.00028 21.0 1.0 0.00028 21.0 1.0 12.2 14 0 0 14 14 14 5 Zinc-finger of C2H2 type zf-C2H2 PF00096.24 NM_033400.2_3 - 0.0012 19.1 6.6 0.0069 16.7 0.8 14.8 19 0 0 19 19 19 6 Zinc finger, C2H2 type LIM_bind PF01803.14 NM_033400.2_3 - 0.044 13.2 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 LIM-domain binding protein AKAP95 PF04988.10 NM_033400.2_3 - 0.53 10.4 37.0 9.1 6.3 0.1 8.7 9 0 0 9 9 9 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_4 PF13894.4 NM_033400.2_3 - 3.3 8.6 122.1 0.51 11.2 0.2 17.9 19 0 0 19 19 19 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_033400.2_3 - 9.9 6.5 68.2 0.44 10.8 0.1 12.5 15 0 0 15 15 15 0 Zinc-finger double-stranded RNA-binding C2 PF00168.28 NM_175733.3_1 - 2.8e-52 175.2 0.1 1.2e-25 89.6 0.1 2.3 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.22 NM_175733.3_1 - 0.01 15.8 0.0 5.1 7.0 0.0 2.4 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 TMEM239 PF15841.3 NM_001318207.1_1 - 4.8e-86 286.0 21.9 7.3e-86 285.4 21.9 1.3 1 0 0 1 1 1 1 Transmembrane protein 239 family GKAP PF03359.11 NM_001242765.1_2 - 9.8e-114 380.4 10.9 1.5e-113 379.7 2.2 2.3 2 0 0 2 2 2 2 Guanylate-kinase-associated protein (GKAP) protein SH3BGR PF04908.13 NM_001317744.1_1 - 3.2e-39 133.0 0.3 6.9e-39 131.9 0.0 1.7 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein CHD5 PF04420.12 NM_001317744.1_1 - 1.6e-17 63.7 0.7 2.5e-17 63.1 0.7 1.2 1 0 0 1 1 1 1 CHD5-like protein Glutaredoxin PF00462.22 NM_001317744.1_1 - 0.00038 20.5 0.0 0.0011 19.0 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin DUF1043 PF06295.10 NM_001317744.1_1 - 0.0014 18.5 1.6 0.003 17.4 1.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) Forkhead PF00250.16 NM_004474.3_2 - 1.9e-36 124.1 0.0 2.7e-36 123.6 0.0 1.2 1 0 0 1 1 1 1 Forkhead domain Clat_adaptor_s PF01217.18 NM_001254726.1_3 - 2.4e-28 98.7 2.8 3.4e-28 98.2 2.8 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CLTH PF10607.7 NM_017896.2_1 - 7.2e-33 113.4 4.5 1e-32 112.9 4.5 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.9 NM_017896.2_1 - 3.9e-11 42.4 0.5 5.7e-10 38.7 0.1 2.8 3 0 0 3 3 3 1 LisH Muskelin_N PF06588.9 NM_001321316.1_2 - 3.9e-99 330.3 0.8 5.7e-99 329.8 0.8 1.2 1 0 0 1 1 1 1 Muskelin N-terminus Kelch_3 PF13415.4 NM_001321316.1_2 - 1.6e-18 66.3 5.6 1.2e-09 38.1 0.0 4.5 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.23 NM_001321316.1_2 - 7.3e-15 54.1 14.3 8.1e-06 25.2 0.3 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.4 NM_001321316.1_2 - 3.5e-13 49.1 5.7 0.00023 20.9 0.1 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.4 NM_001321316.1_2 - 4.8e-12 45.6 4.9 0.026 14.7 0.1 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.4 NM_001321316.1_2 - 1.1e-10 41.0 8.5 0.0033 17.2 0.2 5.5 5 1 0 5 5 5 2 Kelch motif F5_F8_type_C PF00754.23 NM_001321316.1_2 - 1.3e-07 31.6 0.0 2.3e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Kelch_2 PF07646.13 NM_001321316.1_2 - 0.016 15.0 10.9 0.63 10.0 0.1 5.0 6 0 0 6 6 6 0 Kelch motif Sad1_UNC PF07738.11 NM_001321316.1_2 - 0.063 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal GRIP PF01465.18 NM_002078.4_1 - 2.3e-09 36.9 0.1 2.3e-09 36.9 0.1 3.0 3 0 0 3 3 3 1 GRIP domain ASC PF00858.22 NM_001130413.3_2 - 9.3e-84 281.6 2.0 2.3e-83 280.3 0.0 1.9 2 0 0 2 2 2 1 Amiloride-sensitive sodium channel UPA PF17217.1 NM_003728.3_3 - 2.1e-71 238.3 0.4 3.8e-71 237.5 0.4 1.4 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.18 NM_003728.3_3 - 8.6e-32 109.2 0.0 1.7e-31 108.3 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain Death PF00531.20 NM_003728.3_3 - 1e-13 51.1 0.0 2.4e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 Death domain Ig_3 PF13927.4 NM_003728.3_3 - 3.7e-11 43.4 0.2 7e-08 32.8 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 NM_003728.3_3 - 2.8e-10 40.0 1.7 1.5e-09 37.6 0.1 2.8 3 0 0 3 3 3 1 Immunoglobulin I-set domain TSP_1 PF00090.17 NM_003728.3_3 - 9e-10 38.5 29.0 1.5e-07 31.3 8.8 2.9 2 0 0 2 2 2 2 Thrombospondin type 1 domain Ig_2 PF13895.4 NM_003728.3_3 - 1.9e-05 24.8 0.0 0.00033 20.8 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.23 NM_003728.3_3 - 0.00012 22.1 0.1 0.00051 20.0 0.0 2.2 3 0 0 3 3 3 1 Immunoglobulin domain DUF1446 PF07287.9 NM_003728.3_3 - 0.17 10.4 0.0 0.26 9.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1446) LRR_9 PF14580.4 NM_001195280.1_2 - 4.7e-18 65.1 3.4 9.6e-18 64.2 1.7 1.9 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 NM_001195280.1_2 - 1.8e-11 43.9 10.2 0.00015 21.9 1.7 3.3 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_001195280.1_2 - 0.00023 20.7 14.5 0.016 14.8 7.3 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.31 NM_001195280.1_2 - 3.7 8.3 12.1 44 5.0 0.4 4.5 3 2 0 3 3 3 0 Leucine Rich Repeat Integrin_alpha2 PF08441.10 NM_002210.4_1 - 3.7e-123 411.7 0.0 4.4e-123 411.5 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 NM_002210.4_1 - 7e-27 93.1 25.0 2.4e-07 30.6 3.0 4.6 4 0 0 4 4 4 4 FG-GAP repeat VCBS PF13517.4 NM_002210.4_1 - 5.9e-14 52.3 10.8 0.00011 22.6 0.1 4.2 3 1 1 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 NM_002210.4_1 - 0.0002 21.0 0.7 0.00042 20.0 0.7 1.6 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region LYRIC PF15686.3 NM_002210.4_1 - 0.00075 19.0 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family Peptidase_S24 PF00717.21 NM_001244606.1_1 - 4.8e-09 35.9 0.3 1.1e-08 34.7 0.1 1.7 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.7 NM_001244606.1_1 - 0.00013 21.6 0.1 0.03 14.0 0.0 2.5 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Ig_3 PF13927.4 NM_001242356.2_3 - 8.9e-05 22.9 0.0 0.00015 22.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 NM_001242356.2_3 - 0.001 19.1 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_001242356.2_3 - 0.0023 18.1 0.0 0.0035 17.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain PRY PF13765.4 NM_001317943.1_1 - 1e-12 47.3 0.1 2.1e-12 46.3 0.1 1.6 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 NM_001317943.1_1 - 3.2e-07 30.4 0.0 6e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 NM_001317943.1_1 - 7.3e-05 22.7 0.2 0.00024 21.1 0.0 2.0 2 0 0 2 2 2 1 B-box zinc finger Fis1_TPR_N PF14852.4 NM_001317943.1_3 - 0.3 10.6 0.7 0.65 9.6 0.7 1.5 1 0 0 1 1 1 0 Fis1 N-terminal tetratricopeptide repeat 7tm_4 PF13853.4 NM_001005204.1_1 - 9.3e-58 196.0 23.5 1.1e-57 195.8 23.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005204.1_1 - 5.9e-22 78.0 23.9 9.5e-22 77.4 23.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PTS_EIIB PF00367.18 NM_001005204.1_1 - 0.077 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 phosphotransferase system, EIIB STAG PF08514.9 NM_001282418.1_2 - 1.2e-37 128.1 0.1 4.1e-37 126.4 0.1 1.9 1 0 0 1 1 1 1 STAG domain AdoHcyase_NAD PF00670.19 NM_001282418.1_2 - 0.076 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain CSD PF00313.20 NM_007158.5_1 - 1.1e-82 271.7 17.8 3.2e-17 62.0 0.2 9.2 9 0 0 9 9 9 6 'Cold-shock' DNA-binding domain S1-like PF14444.4 NM_007158.5_1 - 2e-14 53.2 17.5 0.075 13.0 0.0 8.1 8 0 0 8 8 8 6 S1-like SUZ-C PF12901.5 NM_007158.5_1 - 2.1e-10 40.2 0.5 9.8e-10 38.1 0.0 2.2 2 0 0 2 2 2 1 SUZ-C motif CusF_Ec PF11604.6 NM_007158.5_1 - 1.1e-07 31.6 10.5 0.14 12.0 0.0 7.6 8 0 0 8 8 8 2 Copper binding periplasmic protein CusF RsgA_N PF16745.3 NM_007158.5_1 - 0.0015 18.1 7.6 6.2 6.5 0.0 6.2 7 0 0 7 7 7 1 RsgA N-terminal domain HasA PF06438.10 NM_007158.5_1 - 0.018 14.5 0.0 0.11 11.9 0.1 2.1 2 0 0 2 2 2 0 Heme-binding protein A (HasA) DUF3857 PF12969.5 NM_007158.5_1 - 0.091 12.7 0.1 7 6.6 0.0 3.3 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3857) MazE_antitoxin PF04014.16 NM_007158.5_1 - 9.9 6.1 10.5 12 5.8 0.1 4.8 6 0 0 6 6 6 0 Antidote-toxin recognition MazE, bacterial antitoxin Herpes_TK_C PF08465.8 NM_001206682.1_2 - 0.052 13.2 0.1 0.1 12.2 0.1 1.4 1 0 0 1 1 1 0 Thymidine kinase from Herpesvirus C-terminal zf-C2H2 PF00096.24 NM_001206682.1_3 - 0.0024 18.1 1.1 0.0024 18.1 1.1 1.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_006959.2_1 - 1.1e-117 379.5 136.3 1.6e-08 34.5 0.3 19.5 19 1 0 19 19 19 16 Zinc-finger double domain zf-C2H2 PF00096.24 NM_006959.2_1 - 4.1e-74 241.0 157.3 3.2e-06 27.2 1.4 18.0 18 0 0 18 18 18 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_006959.2_1 - 1.3e-42 140.6 150.2 0.0021 18.6 1.4 18.1 18 0 0 18 18 17 17 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_006959.2_1 - 4.5e-22 77.4 118.6 3.5e-05 23.5 0.3 18.1 17 1 0 17 17 16 13 C2H2-type zinc finger KRAB PF01352.25 NM_006959.2_1 - 1.7e-18 65.9 0.1 2.9e-18 65.1 0.1 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_006959.2_1 - 5.1e-10 39.2 98.1 0.0091 16.0 2.5 11.5 6 3 5 12 12 12 10 Zinc ribbon domain FAM178 PF14816.4 NM_006959.2_1 - 4.2e-05 22.6 7.9 7.2 5.3 0.0 7.4 2 2 6 9 9 9 1 Family of unknown function, FAM178 zinc_ribbon_15 PF17032.3 NM_006959.2_1 - 0.011 16.3 74.0 0.16 12.6 1.6 9.8 2 1 11 13 13 13 0 zinc-ribbon family zf-met PF12874.5 NM_006959.2_1 - 0.016 15.4 1.7 0.016 15.4 1.7 15.0 17 0 0 17 17 16 0 Zinc-finger of C2H2 type Ribosomal_L31 PF01197.16 NM_006959.2_1 - 0.41 10.8 23.0 1.3 9.1 0.2 7.0 3 2 4 7 7 7 0 Ribosomal protein L31 zf-ribbon_3 PF13248.4 NM_006959.2_1 - 8.5 5.8 63.8 6.1 6.3 0.1 15.4 17 0 0 17 17 17 0 zinc-ribbon domain ERp29_N PF07912.11 NM_006817.3_2 - 9.7e-56 187.2 0.3 1.4e-55 186.7 0.3 1.2 1 0 0 1 1 1 1 ERp29, N-terminal domain ERp29 PF07749.10 NM_006817.3_2 - 1e-23 83.9 0.1 1.6e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Melittin PF01372.15 NM_006817.3_3 - 1.3 8.9 5.3 0.48 10.3 0.7 2.6 3 0 0 3 3 3 0 Melittin CCDC158 PF15921.3 NM_001042784.1_1 - 0 2418.1 103.5 0 2417.9 103.5 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 158 KH_4 PF13083.4 NM_001042784.1_1 - 0.038 13.7 1.9 0.089 12.6 0.1 2.6 2 0 0 2 2 2 0 KH domain Crust_neuro_H PF03858.11 NM_001042784.1_1 - 0.072 13.8 1.1 0.26 12.0 0.1 2.6 2 0 0 2 2 2 0 Crustacean neurohormone H Shugoshin_N PF07558.9 NM_001042784.1_1 - 0.19 11.5 12.4 2.7 7.8 0.7 5.6 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region DUF4407 PF14362.4 NM_001042784.1_1 - 1.5 7.9 92.2 0.038 13.2 14.2 6.5 2 1 4 6 6 6 0 Domain of unknown function (DUF4407) zf-H2C2_5 PF13909.4 NM_022095.3_1 - 8e-32 108.5 78.1 2.4e-07 30.3 6.0 9.9 10 0 0 10 10 10 8 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.4 NM_022095.3_1 - 5.5e-25 85.8 102.2 0.00033 21.1 0.5 13.6 13 0 0 13 13 13 12 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_022095.3_1 - 6.2e-24 83.0 110.8 0.00045 20.4 0.5 13.4 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_022095.3_1 - 1.3e-21 75.8 104.4 8.7e-07 29.0 1.8 14.1 16 0 0 16 16 16 7 Zinc-finger double domain zf-C2H2_6 PF13912.4 NM_022095.3_1 - 2.2e-05 24.2 0.1 2.2e-05 24.2 0.1 8.9 8 0 0 8 8 8 3 C2H2-type zinc finger ADK_lid PF05191.12 NM_022095.3_1 - 0.0036 17.1 3.2 0.0036 17.1 3.2 4.2 5 0 0 5 5 5 1 Adenylate kinase, active site lid Ribosomal_60s PF00428.17 NM_022095.3_1 - 0.057 13.8 0.3 0.057 13.8 0.3 4.7 5 1 0 5 5 5 0 60s Acidic ribosomal protein zf-C2H2_2 PF12756.5 NM_022095.3_1 - 0.082 13.1 0.1 0.082 13.1 0.1 11.1 4 2 4 10 10 10 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.6 NM_022095.3_1 - 0.76 10.0 0.0 0.76 10.0 0.0 8.8 9 1 1 10 10 10 0 Zinc-finger double-stranded RNA-binding COMMD1_N PF17221.1 NM_001321781.1_1 - 6.4e-19 68.0 0.4 1e-18 67.3 0.4 1.3 1 0 0 1 1 1 1 COMMD1 N-terminal domain COMM_domain PF07258.12 NM_001321781.1_1 - 5e-12 45.6 0.0 8.3e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 COMM domain TNFR_c6 PF00020.16 NM_001324201.1_1 - 3.8e-10 39.9 32.1 4.8e-07 29.9 7.6 3.2 3 0 0 3 3 3 2 TNFR/NGFR cysteine-rich region FAM27 PF15832.3 NM_001324201.1_3 - 0.33 11.4 5.4 0.64 10.5 5.4 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family LRR_8 PF13855.4 NM_033014.3_1 - 2.2e-16 59.2 6.8 1e-08 34.6 0.2 3.9 3 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_033014.3_1 - 5.9e-09 35.9 10.5 0.00011 22.4 1.7 4.1 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_033014.3_1 - 0.13 12.7 11.5 7.1 7.4 0.0 5.9 5 1 0 5 5 5 0 Leucine Rich Repeat G-alpha PF00503.18 NM_001309840.1_1 - 1.2e-97 327.1 0.0 1.5e-97 326.8 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 NM_001309840.1_1 - 1.3e-13 50.7 1.0 3.2e-13 49.4 0.5 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.11 NM_001309840.1_1 - 0.04 14.0 0.5 0.099 12.8 0.2 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SNF PF00209.16 NM_016615.4_1 - 3.8e-245 814.4 35.8 4.5e-245 814.1 35.8 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family V-set PF07686.15 NM_001145873.1_3 - 1.2e-14 54.3 0.0 1.2e-14 54.3 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001145873.1_3 - 0.00038 20.9 0.0 0.00097 19.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_001145873.1_3 - 0.0092 15.9 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain 3Beta_HSD PF01073.17 NM_001129765.1_1 - 1.8e-62 210.7 0.0 2.5e-62 210.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 NM_001129765.1_1 - 3.1e-33 115.1 0.0 4.2e-33 114.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 NM_001129765.1_1 - 1.3e-15 57.4 0.0 9.5e-15 54.6 0.0 2.1 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 NM_001129765.1_1 - 3.4e-15 56.3 0.0 5e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 NM_001129765.1_1 - 6.2e-10 38.5 0.0 9.4e-10 37.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.10 NM_001129765.1_1 - 2.3e-08 33.4 0.0 0.00072 18.7 0.0 2.4 2 1 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.13 NM_001129765.1_1 - 1.9e-07 30.4 0.0 1e-06 28.0 0.0 2.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.11 NM_001129765.1_1 - 0.00048 19.6 0.0 0.00083 18.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_2 PF03446.13 NM_001129765.1_1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase DUF2476 PF10630.7 NM_001007534.2_1 - 0.01 15.9 9.9 0.01 15.9 9.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2476) 7tm_2 PF00002.22 NM_000160.4_2 - 2.2e-80 269.4 11.7 3.2e-80 268.8 11.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_000160.4_2 - 6.7e-16 58.2 6.9 2.1e-15 56.6 6.9 1.9 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.9 NM_000160.4_2 - 0.015 14.3 7.5 0.023 13.7 7.5 1.3 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor VSP PF03302.11 NM_000160.4_2 - 0.18 10.5 0.5 0.26 10.0 0.5 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Sds3 PF08598.9 NM_032352.3_1 - 1.5e-23 83.9 9.1 5.9e-23 81.9 9.8 1.3 1 1 1 2 2 2 1 Sds3-like Astro_capsid_p PF12226.6 NM_032352.3_1 - 6.8 5.6 8.9 10 5.0 8.9 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TORC_M PF12885.5 NM_015321.2_2 - 1.8e-67 226.1 7.7 1.8e-67 226.1 7.7 2.3 2 1 0 2 2 2 1 Transducer of regulated CREB activity middle domain TORC_C PF12886.5 NM_015321.2_2 - 2.5e-32 111.1 2.2 4.4e-32 110.3 2.2 1.4 1 0 0 1 1 1 1 Transducer of regulated CREB activity, C terminus TORC_N PF12884.5 NM_015321.2_2 - 1.7e-23 83.1 0.0 4.3e-23 81.7 0.0 1.8 1 0 0 1 1 1 1 Transducer of regulated CREB activity, N terminus MAGE PF01454.17 NM_020932.2_3 - 1.3e-32 113.1 0.0 2.3e-16 60.0 0.0 4.1 2 2 1 3 3 3 3 MAGE family Mito_carr PF00153.25 NM_014252.3_2 - 1.1e-58 195.0 3.2 1.4e-19 69.7 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein COE1_DBD PF16422.3 NM_001324108.1_3 - 3.1e-146 484.7 1.2 4.3e-146 484.3 1.2 1.2 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.3 NM_001324108.1_3 - 1.5e-35 120.5 3.0 2e-29 100.9 0.4 2.4 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.22 NM_001324108.1_3 - 8.7e-12 44.8 0.3 2.1e-11 43.6 0.3 1.7 1 0 0 1 1 1 1 IPT/TIG domain SSXRD PF09514.8 NM_021014.3_3 - 1.6e-15 56.3 0.8 3.3e-15 55.2 0.8 1.6 1 0 0 1 1 1 1 SSXRD motif KRAB PF01352.25 NM_021014.3_3 - 0.00094 18.7 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 KRAB box DEC1 PF15859.3 NM_017418.2_1 - 2.1e-43 146.1 0.1 3.4e-43 145.5 0.1 1.3 1 0 0 1 1 1 1 Deleted in esophageal cancer 1 family CUB PF00431.18 NM_139208.2_3 - 4.6e-14 52.6 0.0 7.8e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 CUB domain EGF_CA PF07645.13 NM_139208.2_3 - 4.6e-08 33.0 5.2 8e-08 32.2 5.2 1.4 1 0 0 1 1 1 1 Calcium-binding EGF domain FXa_inhibition PF14670.4 NM_139208.2_3 - 3.9e-06 26.9 8.6 3.9e-06 26.9 8.6 1.9 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.5 NM_139208.2_3 - 0.00071 19.3 2.8 0.00071 19.3 2.8 3.0 3 0 0 3 3 3 1 Complement Clr-like EGF-like EGF PF00008.25 NM_139208.2_3 - 0.0077 16.4 6.6 0.02 15.0 6.6 1.8 1 0 0 1 1 1 1 EGF-like domain Hormone_1 PF00103.18 NM_000515.4_2 - 1e-61 208.3 0.0 1.3e-61 208.0 0.0 1.1 1 0 0 1 1 1 1 Somatotropin hormone family LRR_4 PF12799.5 NM_031427.3_1 - 1.4e-09 37.9 9.4 0.00014 22.0 5.3 3.3 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_031427.3_1 - 5.3e-07 29.2 0.8 1.5e-05 24.4 0.7 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.4 NM_031427.3_1 - 5.8e-05 22.6 5.9 0.12 12.0 3.5 2.6 2 0 0 2 2 2 2 Leucine rich repeat DUF4431 PF14485.4 NM_015496.4_1 - 0.11 12.1 1.6 0.25 11.0 1.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4431) VIR_N PF15912.3 NM_015496.4_3 - 2.7e-101 338.5 28.2 2.7e-101 338.5 28.2 1.8 1 1 1 2 2 2 1 Virilizer, N-terminal Mpp10 PF04006.10 NM_015496.4_3 - 0.14 10.5 18.0 0.24 9.7 18.0 1.3 1 0 0 1 1 1 0 Mpp10 protein AKNA PF12443.6 NM_152763.4_1 - 1.7e-40 137.5 20.4 1.3e-35 121.8 11.1 3.2 3 0 0 3 3 3 2 AT-hook-containing transcription factor YtxH PF12732.5 NM_152763.4_1 - 0.05 14.0 0.6 0.05 14.0 0.6 3.1 4 0 0 4 4 4 0 YtxH-like protein DZR PF12773.5 NM_152763.4_1 - 1.1 9.2 7.8 0.11 12.4 2.4 2.2 2 0 0 2 2 2 0 Double zinc ribbon TRADD_N PF09034.8 NM_003789.3_3 - 3.9e-46 155.6 0.2 6.6e-46 154.8 0.2 1.4 1 0 0 1 1 1 1 TRADD, N-terminal domain Death PF00531.20 NM_003789.3_3 - 3.1e-07 30.3 2.0 8.5e-07 28.9 0.3 2.3 3 0 0 3 3 3 1 Death domain zf-H2C2_2 PF13465.4 NM_024106.2_1 - 1.6e-69 227.3 127.2 4.7e-09 36.2 1.0 18.3 21 0 0 21 21 21 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_024106.2_1 - 1.5e-49 163.7 116.3 6e-06 26.3 1.8 15.7 16 0 0 16 16 16 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_024106.2_1 - 2.4e-33 111.7 108.2 0.00048 20.6 1.3 15.5 15 0 0 15 15 15 12 C2H2-type zinc finger KRAB PF01352.25 NM_024106.2_1 - 1.4e-23 82.2 0.8 2.4e-23 81.4 0.8 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_024106.2_1 - 8.8e-15 54.1 85.4 0.014 15.2 0.8 13.7 14 0 0 14 14 14 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_024106.2_1 - 1e-05 25.6 81.1 0.00041 20.4 1.7 13.4 14 0 0 14 14 14 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_024106.2_1 - 0.0029 17.6 71.9 0.08 12.9 2.3 9.4 5 1 5 11 11 11 8 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_024106.2_1 - 0.0032 17.1 0.2 0.0032 17.1 0.2 12.7 14 0 0 14 14 14 2 zinc-finger C2H2-type DUF3268 PF11672.6 NM_024106.2_1 - 0.26 11.5 35.8 0.17 12.1 1.4 5.9 4 1 0 6 6 6 0 zinc-finger-containing domain zf-H2C2_2 PF13465.4 NM_024106.2_3 - 0.21 12.0 3.1 0.36 11.3 0.2 3.0 2 0 0 2 2 2 0 Zinc-finger double domain 7tm_4 PF13853.4 NM_001001667.1_1 - 4.1e-49 167.7 17.7 5e-49 167.4 17.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001001667.1_1 - 6e-22 78.0 16.6 9.8e-22 77.3 16.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001001667.1_1 - 4.6e-05 22.8 6.6 4.6e-05 22.8 6.6 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2475 PF10629.7 NM_001322426.1_1 - 9.4e-26 89.7 0.6 9.4e-26 89.7 0.6 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2475) Ank_2 PF12796.5 NM_001031739.2_1 - 6.1e-40 135.6 8.6 1.2e-13 51.3 0.2 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_001031739.2_1 - 9.6e-25 83.8 2.3 0.0026 18.0 0.0 6.7 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.28 NM_001031739.2_1 - 2.9e-22 78.0 5.1 0.00023 21.3 0.2 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.4 NM_001031739.2_1 - 1.3e-21 76.5 2.9 1.7e-07 31.5 0.2 4.5 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001031739.2_1 - 2.5e-21 75.3 4.0 6.4e-07 29.4 0.1 5.1 2 2 4 6 6 6 4 Ankyrin repeats (many copies) SOCS_box PF07525.14 NM_001031739.2_1 - 1.6e-09 37.8 3.5 4.3e-09 36.4 3.5 1.7 1 0 0 1 1 1 1 SOCS box Pkinase PF00069.23 NM_015076.4_1 - 9.5e-61 205.3 0.0 1.3e-60 204.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_015076.4_1 - 4.5e-25 88.3 0.0 7.2e-25 87.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_015076.4_1 - 0.023 13.9 0.1 0.038 13.2 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_015076.4_1 - 0.083 12.7 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sec6 PF06046.11 NM_006291.2_3 - 9.7e-109 364.2 0.0 1.2e-108 363.9 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec6 SR-25 PF10500.7 NM_006291.2_3 - 0.058 12.9 4.6 0.092 12.2 4.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RhoGEF PF00621.18 NM_001114090.1_3 - 8.6e-35 120.5 6.7 1.8e-34 119.4 6.7 1.6 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 NM_001114090.1_3 - 8.6e-12 44.3 0.0 2e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001114090.1_3 - 2.4e-11 43.2 0.0 4.2e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001114090.1_3 - 1.3e-07 31.1 0.1 3.9e-07 29.5 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain PH PF00169.27 NM_001114090.1_3 - 6.3e-06 26.5 0.0 1.8e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.3 NM_001114090.1_3 - 0.021 14.7 0.0 0.056 13.3 0.0 1.7 1 0 0 1 1 1 0 PH domain UAA PF08449.9 NM_001286520.1_1 - 4.4e-73 246.0 11.9 5.7e-73 245.6 11.9 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.18 NM_001286520.1_1 - 4.7e-07 29.9 19.6 0.00018 21.5 12.5 2.4 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.8 NM_001286520.1_1 - 0.056 12.3 9.6 0.16 10.7 1.0 2.1 2 0 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like PTPLA PF04387.12 NM_001321883.1_2 - 1.1e-33 116.2 14.1 2.8e-33 114.9 14.1 1.7 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA RNB PF00773.17 NM_001323937.1_3 - 4.7e-88 295.5 0.0 7.8e-88 294.8 0.0 1.4 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.1 NM_001323937.1_3 - 6.3e-07 29.1 0.0 3.4e-06 26.8 0.0 2.3 2 0 0 2 2 2 1 S1 domain Rrp44_CSD1 PF17216.1 NM_001323937.1_3 - 1.5e-06 27.9 0.0 2.9e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain DEP PF00610.19 NM_001319311.1_1 - 9.6e-20 70.3 1.8 1.6e-19 69.6 0.2 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Bromo_TP PF07524.11 NM_014860.2_2 - 3.3e-24 84.6 0.3 5.7e-24 83.8 0.0 1.6 2 0 0 2 2 2 1 Bromodomain associated Ras PF00071.20 NM_001242644.1_2 - 7.4e-47 158.8 0.2 1.2e-46 158.1 0.2 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001242644.1_2 - 2.4e-19 69.6 0.0 4.7e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001242644.1_2 - 5.7e-09 35.5 0.1 9.1e-09 34.9 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 NM_001242644.1_2 - 0.025 14.0 0.0 0.039 13.3 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF1467 PF07330.10 NM_001242644.1_3 - 0.17 11.7 1.6 0.37 10.6 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) Dickkopf_N PF04706.10 NM_013253.4_1 - 6.6e-16 58.4 16.4 6.6e-16 58.4 16.4 3.1 3 0 0 3 3 3 1 Dickkopf N-terminal cysteine-rich region UPF0506 PF11703.6 NM_013253.4_1 - 0.0025 18.0 15.2 0.0025 18.0 15.2 2.5 2 0 0 2 2 2 1 UPF0506 HSCB_C PF07743.11 NM_013253.4_1 - 2.1 8.8 6.0 10 6.6 1.9 2.2 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain EF-hand_7 PF13499.4 NM_147183.3_1 - 2.3e-23 82.3 3.0 4.2e-17 62.2 0.3 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_147183.3_1 - 6.1e-20 69.1 9.2 1.8e-07 30.1 0.2 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_147183.3_1 - 4e-17 60.5 8.1 3e-05 23.5 0.1 4.4 6 0 0 6 6 6 3 EF-hand domain EF-hand_5 PF13202.4 NM_147183.3_1 - 1.4e-15 55.8 4.0 8.4e-05 21.8 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 NM_147183.3_1 - 6.8e-13 48.0 6.4 6.8e-06 25.6 0.2 3.7 1 1 2 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_147183.3_1 - 1.1e-06 28.7 1.5 0.00011 22.4 0.5 3.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_147183.3_1 - 0.01 15.6 0.9 0.046 13.6 0.1 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.4 NM_147183.3_1 - 0.036 14.3 0.3 4.1 7.7 0.0 3.2 1 1 1 2 2 2 0 EF-hand domain Caleosin PF05042.11 NM_147183.3_1 - 0.86 9.4 6.0 19 5.0 0.1 3.3 2 1 1 3 3 3 0 Caleosin related protein Ribosomal_L7Ae PF01248.24 NM_001256397.1_1 - 8.6e-08 31.7 0.2 1.4e-07 31.0 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RPE65 PF03055.13 NM_001256397.1_3 - 2.8e-112 375.8 0.0 3.4e-112 375.5 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein zf-H2C2_2 PF13465.4 NM_001288592.1_2 - 1.2e-35 120.2 32.6 3.8e-08 33.3 0.9 6.6 7 0 0 7 7 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001288592.1_2 - 7.5e-31 104.7 30.0 9e-07 28.9 0.6 5.6 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001288592.1_2 - 1.7e-15 56.2 27.9 0.0015 19.0 0.4 5.9 5 0 0 5 5 5 5 C2H2-type zinc finger KRAB PF01352.25 NM_001288592.1_2 - 7.4e-12 44.6 0.0 1.3e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001288592.1_2 - 6.6e-11 41.8 21.6 0.0061 16.3 0.2 5.8 5 0 0 5 5 5 4 C2H2-type zinc finger XPA_N PF01286.16 NM_001288592.1_2 - 3e-06 27.0 12.6 2 8.4 0.1 5.4 5 0 0 5 5 5 3 XPA protein N-terminal zf-C2H2_jaz PF12171.6 NM_001288592.1_2 - 2.5e-05 24.3 15.5 0.56 10.4 0.1 5.3 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001288592.1_2 - 0.00013 21.8 24.5 0.017 15.1 4.8 4.2 2 2 3 5 5 5 3 Zinc ribbon domain ZZ PF00569.15 NM_001288592.1_2 - 0.0093 15.6 15.2 4.3 7.1 0.1 5.2 5 0 0 5 5 5 1 Zinc finger, ZZ type zinc_ribbon_15 PF17032.3 NM_001288592.1_2 - 0.022 15.4 16.7 0.52 11.0 1.1 3.2 1 1 3 4 4 4 0 zinc-ribbon family C1_4 PF07975.10 NM_001288592.1_2 - 0.041 14.0 15.7 0.29 11.3 0.8 3.9 2 1 2 4 4 4 0 TFIIH C1-like domain DZR PF12773.5 NM_001288592.1_2 - 0.16 11.9 18.8 5.1e+03 -2.5 18.8 3.3 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.17 NM_001288592.1_2 - 1.2 9.1 14.5 12 5.8 4.8 3.2 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HE PF16278.3 NM_001288592.1_2 - 1.4 9.3 22.4 3.4 8.1 4.6 5.1 1 1 3 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger YhfH PF14149.4 NM_001288592.1_2 - 1.6 8.6 14.4 32 4.5 0.3 5.0 5 0 0 5 5 5 0 YhfH-like protein Zn_ribbon_recom PF13408.4 NM_001288592.1_2 - 1.9 8.9 16.1 66 4.0 2.4 4.5 1 1 2 3 3 2 0 Recombinase zinc beta ribbon domain GATA PF00320.25 NM_001288592.1_2 - 3.7 7.1 15.8 2.1 7.9 0.1 4.2 4 1 1 5 5 4 0 GATA zinc finger zf-C2H2_11 PF16622.3 NM_001288592.1_2 - 4.6 7.0 15.1 5.8 6.6 0.1 4.9 5 0 0 5 5 5 0 zinc-finger C2H2-type TFIIS_C PF01096.16 NM_001288592.1_2 - 4.6 7.0 20.4 8.6 6.2 0.4 5.3 5 0 0 5 5 5 0 Transcription factor S-II (TFIIS) FYVE PF01363.19 NM_001288592.1_2 - 6.5 6.8 15.5 4.9 7.2 2.3 3.0 1 1 1 2 2 2 0 FYVE zinc finger Reprolysin PF01421.17 NM_003815.4_2 - 5.6e-55 186.2 0.0 1e-54 185.4 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_003815.4_2 - 1e-27 96.7 1.6 1e-27 96.7 1.6 2.8 3 0 0 3 3 2 1 ADAM cysteine-rich Disintegrin PF00200.21 NM_003815.4_2 - 3.3e-21 75.7 24.3 3.3e-21 75.7 24.3 4.0 3 1 0 3 3 2 1 Disintegrin Pep_M12B_propep PF01562.17 NM_003815.4_2 - 1.4e-14 54.4 0.0 2.9e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_003815.4_2 - 4.1e-14 53.1 0.0 7.3e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 NM_003815.4_2 - 6.9e-10 39.4 0.0 1.2e-09 38.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_003815.4_2 - 3.7e-07 30.1 0.0 6.3e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_003815.4_2 - 2.2e-05 24.1 0.0 3.7e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like CD20 PF04103.13 NM_003815.4_2 - 0.0042 17.1 0.2 0.0078 16.2 0.2 1.3 1 0 0 1 1 1 1 CD20-like family Peptidase_M10 PF00413.22 NM_003815.4_2 - 0.047 13.4 0.1 0.071 12.8 0.1 1.2 1 0 0 1 1 1 0 Matrixin Peptidase_M43 PF05572.11 NM_003815.4_2 - 0.2 11.4 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A DUF4953 PF16313.3 NM_003815.4_2 - 0.21 10.6 0.1 0.34 9.9 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_C65 PF10275.7 NM_017670.2_2 - 6.9e-86 287.5 2.2 9.2e-86 287.1 2.2 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.17 NM_017670.2_2 - 4e-06 27.2 0.2 0.00027 21.3 0.2 2.4 1 1 0 1 1 1 1 OTU-like cysteine protease Lipoprotein_7 PF01540.14 NM_017670.2_2 - 0.11 11.7 0.8 0.17 11.0 0.8 1.3 1 0 0 1 1 1 0 Adhesin lipoprotein BAR_3 PF16746.3 NM_001135608.1_3 - 1e-86 290.4 14.5 1e-86 290.4 14.5 1.8 2 0 0 2 2 2 1 BAR domain of APPL family RhoGAP PF00620.25 NM_001135608.1_3 - 4.6e-40 136.8 0.5 9.9e-40 135.7 0.5 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 NM_001135608.1_3 - 2.5e-09 37.5 0.1 6e-09 36.2 0.1 1.7 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.4 NM_001135608.1_3 - 3.7e-09 36.2 0.0 7.7e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001135608.1_3 - 3.1e-07 29.7 0.0 5.6e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001135608.1_3 - 0.00012 21.6 0.0 0.00022 20.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain IMD PF08397.9 NM_001135608.1_3 - 0.00024 20.4 5.4 0.00048 19.4 5.4 1.4 1 0 0 1 1 1 1 IRSp53/MIM homology domain Arfaptin PF06456.11 NM_001135608.1_3 - 1.5 8.2 8.3 3.2 7.1 8.3 1.5 1 0 0 1 1 1 0 Arfaptin-like domain C2-set_2 PF08205.10 NM_001283051.1_2 - 0.0007 19.5 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 NM_001283051.1_2 - 0.011 16.2 0.0 0.021 15.3 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Pkinase PF00069.23 NM_002753.4_1 - 1.1e-62 211.7 0.0 1.5e-62 211.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_002753.4_1 - 2.3e-28 99.1 0.1 3.3e-28 98.5 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_002753.4_1 - 1.9e-06 27.3 0.2 3.1e-06 26.6 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_002753.4_1 - 0.00095 18.4 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 NM_002753.4_1 - 0.003 17.1 0.3 0.0051 16.3 0.3 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 NM_002753.4_1 - 0.0048 16.7 0.0 0.0078 16.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family BTB PF00651.29 NM_020899.3_3 - 7.9e-14 51.7 0.0 6.1e-10 39.2 0.0 2.2 2 0 0 2 2 2 2 BTB/POZ domain zf-C2H2 PF00096.24 NM_020899.3_3 - 9.6e-14 50.9 36.1 0.061 13.7 2.0 6.7 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_020899.3_3 - 1.1e-08 35.1 38.7 0.16 12.7 0.8 6.8 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_020899.3_3 - 1.3e-05 25.3 33.3 0.01 16.1 0.4 6.9 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_jaz PF12171.6 NM_020899.3_3 - 0.00024 21.2 8.1 0.21 11.8 0.3 4.5 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.4 NM_020899.3_3 - 0.001 18.8 3.1 0.001 18.8 3.1 2.9 4 0 0 4 4 4 1 zinc-finger of a C2HC-type YL1 PF05764.11 NM_020899.3_3 - 0.052 13.5 7.6 0.11 12.5 7.6 1.4 1 0 0 1 1 1 0 YL1 nuclear protein FAM176 PF14851.4 NM_020899.3_3 - 0.076 12.6 0.7 0.15 11.6 0.7 1.4 1 0 0 1 1 1 0 FAM176 family DUF1635 PF07795.9 NM_020899.3_3 - 0.16 11.8 2.2 0.38 10.6 2.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Rrn6 PF10214.7 NM_020899.3_3 - 0.41 8.9 4.0 0.63 8.3 4.0 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor FYDLN_acid PF09538.8 NM_020899.3_3 - 0.83 10.2 10.7 3 8.5 2.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) zf-Di19 PF05605.10 NM_020899.3_3 - 3.3 8.0 16.9 0.38 10.9 0.5 3.9 4 0 0 4 4 3 0 Drought induced 19 protein (Di19), zinc-binding CDC45 PF02724.12 NM_020899.3_3 - 8.7 4.4 5.4 13 3.8 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Na_K-ATPase PF00287.16 NM_001303263.1_3 - 2e-70 237.0 1.0 2.8e-70 236.6 1.0 1.1 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain V-set PF07686.15 NM_001122979.2_1 - 1.3e-15 57.4 0.0 2e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain zf-RING_2 PF13639.4 NM_001256758.1_3 - 2e-13 50.2 6.2 2e-13 50.2 6.2 3.0 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_001256758.1_3 - 5.3e-10 38.8 7.2 5.3e-10 38.8 7.2 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 NM_001256758.1_3 - 5.9e-08 32.2 1.8 5.9e-08 32.2 1.8 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.5 NM_001256758.1_3 - 5e-07 29.8 3.7 1.4e-06 28.4 3.7 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.4 NM_001256758.1_3 - 5.2e-07 29.3 3.7 5.2e-07 29.3 3.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001256758.1_3 - 1.7e-06 27.6 4.8 1.7e-06 27.6 4.8 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001256758.1_3 - 9.1e-06 25.4 2.7 9.1e-06 25.4 2.7 2.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_001256758.1_3 - 9.3e-05 22.2 1.8 9.3e-05 22.2 1.8 3.3 3 0 0 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.4 NM_001256758.1_3 - 0.00042 20.0 3.3 0.00042 20.0 3.3 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 NM_001256758.1_3 - 0.0077 16.1 1.6 0.02 14.8 1.6 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.3 NM_001256758.1_3 - 0.05 13.1 3.0 0.15 11.5 3.0 1.9 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_10 PF16685.3 NM_001256758.1_3 - 0.12 12.4 3.9 0.42 10.7 3.9 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 RINGv PF12906.5 NM_001256758.1_3 - 1.1 9.2 5.8 3.4 7.7 5.8 1.9 1 0 0 1 1 1 0 RING-variant domain SNAP-25 PF00835.17 NM_003825.3_3 - 2.5e-22 78.8 1.9 1.9e-21 76.0 0.6 2.3 2 0 0 2 2 2 1 SNAP-25 family DUF5089 PF17002.3 NM_003825.3_3 - 0.0019 17.9 0.9 0.0019 17.9 0.9 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5089) V-SNARE_C PF12352.6 NM_003825.3_3 - 0.026 14.7 6.5 0.096 12.9 1.8 2.8 2 1 1 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Spc7 PF08317.9 NM_003825.3_3 - 0.39 9.4 3.0 0.69 8.6 3.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Sec20 PF03908.11 NM_003825.3_3 - 1.1 9.1 5.0 0.35 10.7 1.6 1.9 2 0 0 2 2 2 0 Sec20 DUF1664 PF07889.10 NM_003825.3_3 - 3 7.7 6.5 0.86 9.5 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) NO_synthase PF02898.13 NM_001204218.1_1 - 6.8e-193 640.5 0.0 9.2e-193 640.1 0.0 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 NM_001204218.1_1 - 2.8e-86 288.5 0.0 4e-86 288.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 NM_001204218.1_1 - 4.1e-53 179.3 0.0 6.8e-53 178.6 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 NM_001204218.1_1 - 3.5e-21 75.7 0.0 7.3e-21 74.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PDZ PF00595.22 NM_001204218.1_1 - 1.7e-15 57.0 0.1 3.7e-15 55.9 0.1 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001204218.1_1 - 0.0017 18.5 0.0 0.0033 17.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain EF-hand_7 PF13499.4 NM_001040625.1_2 - 6.2e-26 90.5 2.5 4.1e-17 62.3 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 NM_001040625.1_2 - 9.6e-23 77.9 4.3 3.5e-06 26.0 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.4 NM_001040625.1_2 - 1.8e-20 71.3 3.1 1.2e-06 27.6 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_001040625.1_2 - 1.5e-19 68.0 1.8 2e-05 24.0 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 NM_001040625.1_2 - 2e-16 59.4 1.1 2.9e-06 26.8 0.0 3.5 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_001040625.1_2 - 0.00028 21.0 0.1 0.061 13.5 0.0 3.0 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_001040625.1_2 - 0.0043 16.8 0.3 2.2 8.1 0.0 2.9 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Kelch_1 PF01344.23 NM_014458.3_3 - 2.7e-88 289.2 19.9 9e-16 57.1 0.4 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 NM_014458.3_3 - 1.2e-51 171.3 6.9 3.8e-09 36.4 0.0 6.5 2 2 4 6 6 6 6 Kelch motif BACK PF07707.13 NM_014458.3_3 - 4.9e-38 129.2 0.1 9.9e-38 128.2 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_4 PF13418.4 NM_014458.3_3 - 2.9e-36 123.1 5.4 5.4e-06 26.1 0.0 6.4 4 1 2 6 6 6 6 Galactose oxidase, central domain BTB PF00651.29 NM_014458.3_3 - 2.3e-32 111.3 0.3 4.5e-32 110.4 0.3 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.4 NM_014458.3_3 - 8.8e-32 108.6 16.3 1.5e-05 25.0 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_014458.3_3 - 1.1e-27 94.8 10.2 2.5e-06 27.1 0.2 7.1 7 0 0 7 7 7 6 Kelch motif Kelch_5 PF13854.4 NM_014458.3_3 - 0.004 17.0 7.3 4.5 7.2 0.1 5.5 6 0 0 6 6 6 2 Kelch motif Metallophos PF00149.26 NM_006240.2_2 - 4.1e-23 82.8 3.6 1.9e-22 80.7 3.6 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_7 PF13499.4 NM_006240.2_2 - 3e-15 56.3 1.1 6.1e-13 48.9 0.7 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_006240.2_2 - 9.3e-15 52.9 1.8 6.2e-06 25.3 0.1 3.7 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 NM_006240.2_2 - 1.4e-11 43.8 0.9 1.8e-05 24.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_006240.2_2 - 3.5e-11 42.0 0.5 2.5e-05 23.5 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_006240.2_2 - 3.5e-11 42.0 0.7 0.0012 18.5 0.1 3.8 3 0 0 3 3 3 2 EF-hand domain PPP5 PF08321.10 NM_006240.2_2 - 1.6e-08 34.6 0.1 6.7e-08 32.6 0.0 2.1 2 0 0 2 2 2 1 PPP5 TPR repeat region IQ PF00612.25 NM_006240.2_2 - 0.00022 20.6 2.2 0.00053 19.4 2.2 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif EF-hand_4 PF12763.5 NM_006240.2_2 - 0.0013 18.6 3.2 0.049 13.4 0.3 3.3 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand AP4E_app_platf PF14807.4 NM_006240.2_2 - 0.0079 16.4 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform EF-hand_11 PF08976.9 NM_006240.2_2 - 0.023 15.4 0.2 0.066 14.0 0.1 1.8 2 0 0 2 2 1 0 EF-hand domain Arf PF00025.19 NM_001024228.1_1 - 9.2e-78 259.5 0.1 1.3e-77 259.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 NM_001024228.1_1 - 1e-13 51.0 0.0 1.4e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 NM_001024228.1_1 - 4.4e-13 49.4 0.0 6.2e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_001024228.1_1 - 1.2e-11 44.4 0.0 1.7e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 NM_001024228.1_1 - 4.3e-10 39.2 1.0 6.5e-07 28.7 0.2 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 NM_001024228.1_1 - 8.6e-10 38.2 0.0 1.2e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 NM_001024228.1_1 - 0.00022 21.2 0.0 0.00033 20.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 NM_001024228.1_1 - 0.07 12.3 0.5 0.14 11.3 0.1 1.5 2 0 0 2 2 2 0 6-phosphofructo-2-kinase Mcp5_PH PF12814.5 NM_001024228.1_3 - 0.16 11.9 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology 7tm_4 PF13853.4 NM_001005183.1_1 - 6.4e-46 157.2 19.0 8.4e-46 156.8 19.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005183.1_1 - 1.1e-18 67.4 21.1 2.3e-18 66.2 21.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) WSS_VP PF12175.6 NM_001005183.1_1 - 0.097 12.0 0.7 0.16 11.3 0.7 1.4 1 0 0 1 1 1 0 White spot syndrome virus structural envelope protein VP Ets PF00178.20 NM_004433.4_1 - 1.6e-30 105.3 1.4 3e-30 104.4 1.4 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 NM_004433.4_1 - 4.5e-23 80.9 0.1 1.1e-22 79.7 0.1 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain AT_hook PF02178.17 NM_004433.4_1 - 0.42 10.5 5.1 1.1 9.3 5.1 1.8 1 0 0 1 1 1 0 AT hook motif Ras PF00071.20 NM_001306161.1_2 - 8.9e-09 35.0 0.1 1.3e-06 27.9 0.0 2.2 1 1 1 2 2 2 2 Ras family Roc PF08477.11 NM_001306161.1_2 - 2.7e-08 33.9 0.0 4.3e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Neurexophilin PF06312.10 NM_001077639.1_2 - 2.9e-19 69.3 0.0 5.3e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Neurexophilin Trp_DMAT PF11991.6 NM_001077639.1_2 - 0.02 14.2 0.0 0.032 13.5 0.0 1.2 1 0 0 1 1 1 0 Tryptophan dimethylallyltransferase Filamin PF00630.17 NM_001077639.1_2 - 0.041 14.6 0.0 0.089 13.5 0.0 1.5 1 0 0 1 1 1 0 Filamin/ABP280 repeat ubiquitin PF00240.21 NM_014235.4_3 - 2.8e-19 68.5 0.0 4.2e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 NM_014235.4_3 - 5.4e-08 32.4 0.0 7.7e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 NM_014235.4_3 - 0.11 13.0 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain DCX PF03607.15 NM_006269.1_2 - 2.5e-35 120.2 0.0 2.5e-20 72.2 0.0 2.9 2 0 0 2 2 2 2 Doublecortin Ribosomal_L4 PF00573.20 NM_146388.1_3 - 4.4e-47 160.1 0.0 7.2e-47 159.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family F-box-like PF12937.5 NM_024735.4_2 - 6.3e-11 41.8 0.6 6.3e-11 41.8 0.6 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 NM_024735.4_2 - 1.4e-10 40.7 1.0 2.7e-10 39.7 1.0 1.5 1 0 0 1 1 1 1 F-box domain DUF3506 PF12014.6 NM_024735.4_2 - 0.013 15.3 0.1 0.54 10.1 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3506) Ig_3 PF13927.4 NM_153487.3_1 - 4.2e-70 232.2 4.1 9.4e-12 45.3 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 NM_153487.3_1 - 8.6e-56 185.9 0.0 2.9e-11 43.1 0.0 6.3 6 0 0 6 6 6 6 Immunoglobulin I-set domain MAM PF00629.21 NM_153487.3_1 - 2.3e-49 167.2 0.0 3.8e-49 166.5 0.0 1.4 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Ig_2 PF13895.4 NM_153487.3_1 - 7.8e-48 160.6 0.5 3e-08 33.8 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 NM_153487.3_1 - 1.4e-41 140.4 0.0 1.7e-06 28.0 0.0 7.0 6 1 0 6 6 6 6 Immunoglobulin domain V-set PF07686.15 NM_153487.3_1 - 1.2e-18 67.2 10.3 0.11 12.5 0.0 10.5 7 5 1 8 8 8 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_153487.3_1 - 7.1e-08 32.3 1.7 0.081 12.9 0.0 5.1 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_153487.3_1 - 3.8e-05 23.9 0.1 0.064 13.6 0.0 4.0 4 0 0 4 4 4 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 NM_153487.3_1 - 0.00035 20.4 0.1 28 4.7 0.0 5.3 6 0 0 6 6 6 0 Izumo-like Immunoglobulin domain HLH PF00010.24 NM_012259.2_3 - 7.2e-17 61.0 2.9 1.2e-16 60.2 2.9 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.11 NM_012259.2_3 - 1.2e-13 50.9 0.1 2.2e-13 50.0 0.1 1.5 1 0 0 1 1 1 1 Hairy Orange dCache_2 PF08269.9 NM_012259.2_3 - 0.14 11.2 0.1 0.21 10.6 0.1 1.1 1 0 0 1 1 1 0 Cache domain LIDHydrolase PF10230.7 NM_001282722.1_1 - 4.7e-60 203.3 0.0 7.7e-60 202.6 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Homeobox PF00046.27 NM_006492.2_2 - 2.8e-23 81.3 6.3 4.4e-23 80.7 6.3 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_006492.2_2 - 0.0023 17.6 0.2 0.0044 16.8 0.2 1.4 1 0 0 1 1 1 1 Homeobox KN domain Nuf2 PF03800.12 NM_145697.2_1 - 1.2e-35 122.5 1.0 5.2e-35 120.5 0.1 2.4 2 0 0 2 2 2 1 Nuf2 family KELK PF15796.3 NM_145697.2_1 - 0.022 15.1 4.8 0.022 15.1 4.8 5.4 2 2 4 6 6 6 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Spc7 PF08317.9 NM_145697.2_1 - 2.8 6.6 50.6 1.3 7.7 23.0 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein ATG16 PF08614.9 NM_145697.2_1 - 4.1 7.4 33.6 0.38 10.8 15.9 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ADIP PF11559.6 NM_145697.2_1 - 6.7 6.7 45.4 2.2 8.2 15.6 3.8 2 2 1 3 3 3 0 Afadin- and alpha -actinin-Binding Paired_CXXCH_1 PF09699.8 NM_001316888.1_1 - 0.23 11.1 3.3 1.6 8.4 0.1 2.4 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) TMCO5 PF14992.4 NM_152453.3_2 - 1.2e-113 379.1 24.3 1.5e-113 378.9 24.3 1.1 1 0 0 1 1 1 1 TMCO5 family MctB PF11382.6 NM_152453.3_2 - 0.35 10.4 1.9 0.59 9.6 1.9 1.3 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB Reo_sigmaC PF04582.10 NM_152453.3_2 - 0.39 9.9 2.0 0.47 9.7 0.6 1.6 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Shugoshin_N PF07558.9 NM_152453.3_2 - 0.59 9.9 10.5 0.075 12.8 1.2 3.6 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region BRE1 PF08647.9 NM_152453.3_2 - 9.2 6.3 28.8 0.76 9.8 2.5 3.7 2 1 0 3 3 3 0 BRE1 E3 ubiquitin ligase 7tm_1 PF00001.19 NM_001040179.1_1 - 2.6e-41 141.5 18.1 3.7e-41 141.0 18.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_001040179.1_1 - 1.9e-05 24.4 6.0 6.9e-05 22.6 6.0 1.9 1 1 0 1 1 1 1 Olfactory receptor RRM_1 PF00076.20 NM_001322250.1_1 - 1.4e-32 111.2 0.3 6.4e-16 57.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001322250.1_1 - 1.8e-08 34.3 0.2 0.0089 16.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif Quaking_NLS PF16551.3 NM_001322250.1_1 - 1 8.9 2.6 21 4.8 0.0 2.3 2 0 0 2 2 2 0 Putative nuclear localisation signal of quaking Pkinase PF00069.23 NM_001252120.1_2 - 1.7e-56 191.3 0.0 2.4e-56 190.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001252120.1_2 - 1.9e-23 83.0 0.0 2.9e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAS_9 PF13426.5 NM_001252120.1_2 - 1.6e-17 63.5 0.0 6.6e-09 35.8 0.0 3.5 3 0 0 3 3 3 3 PAS domain PAS PF00989.23 NM_001252120.1_2 - 5.7e-11 42.3 0.0 1.5e-06 28.0 0.0 3.8 4 0 0 4 4 4 2 PAS fold Kinase-like PF14531.4 NM_001252120.1_2 - 0.0011 18.2 0.0 0.0062 15.8 0.0 2.1 2 1 0 2 2 2 1 Kinase-like PAS_8 PF13188.5 NM_001252120.1_2 - 0.0027 17.6 0.0 0.13 12.1 0.0 3.0 3 0 0 3 3 3 1 PAS domain PAS_2 PF08446.9 NM_001252120.1_2 - 0.16 12.5 0.2 0.66 10.5 0.0 2.1 3 0 0 3 3 3 0 PAS fold efThoc1 PF11957.6 NM_005131.2_2 - 4.5e-146 487.2 9.9 7.3e-146 486.5 9.9 1.3 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Death PF00531.20 NM_005131.2_2 - 1.5e-18 66.6 1.2 8.9e-18 64.1 0.4 2.5 2 0 0 2 2 2 1 Death domain HsdM_N PF12161.6 NM_005131.2_2 - 9.8 6.6 9.8 4.9 7.6 0.9 3.4 3 1 0 3 3 3 0 HsdM N-terminal domain TMEM52 PF14979.4 NM_178545.3_1 - 3.7e-71 237.7 0.3 4.8e-71 237.3 0.3 1.1 1 0 0 1 1 1 1 Transmembrane 52 Neurensin PF14927.4 NM_178545.3_1 - 0.019 14.5 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 Neurensin Shisa PF13908.4 NM_178545.3_1 - 0.054 13.6 0.0 0.088 12.9 0.0 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator P5CR_dimer PF14748.4 NM_006907.3_3 - 1.5e-36 124.6 0.0 3.3e-36 123.5 0.0 1.6 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.15 NM_006907.3_3 - 1.7e-21 76.5 0.1 2.7e-21 75.8 0.1 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.7 NM_006907.3_3 - 0.0049 16.6 0.5 0.0093 15.7 0.5 1.4 1 0 0 1 1 1 1 Rossmann-like domain NAD_Gly3P_dh_N PF01210.21 NM_006907.3_3 - 0.0099 15.7 1.5 0.052 13.4 1.5 1.9 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.14 NM_006907.3_3 - 0.07 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA KRAB PF01352.25 NM_001277093.1_2 - 1.8e-23 81.8 0.2 3.5e-23 80.9 0.2 1.5 1 0 0 1 1 1 1 KRAB box IL22 PF14565.4 NM_006850.3_3 - 5.1e-05 23.4 0.3 0.00015 21.9 0.3 1.7 1 1 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor IL10 PF00726.15 NM_006850.3_3 - 0.00018 20.9 0.2 0.00034 20.0 0.2 1.4 1 0 0 1 1 1 1 Interleukin 10 Ig_3 PF13927.4 NM_001256503.1_3 - 1.5e-24 86.2 0.2 3.6e-11 43.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_001256503.1_3 - 2.5e-20 72.2 0.0 1.3e-09 37.8 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 NM_001256503.1_3 - 6.7e-19 67.7 0.0 1e-06 28.7 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_001256503.1_3 - 9.4e-18 64.2 0.1 6.4e-08 32.7 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.10 NM_001256503.1_3 - 1.4e-14 53.8 0.0 1e-13 51.0 0.0 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_001256503.1_3 - 4.4e-08 33.4 0.0 9.2e-07 29.1 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin C1-set domain V-set PF07686.15 NM_001256503.1_3 - 1.4e-07 31.5 0.0 0.018 15.0 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin V-set domain Hormone_recep PF00104.28 NM_001030003.2_2 - 3.4e-40 137.7 0.0 5.4e-40 137.1 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_001030003.2_2 - 2.3e-29 101.5 18.4 4.2e-29 100.7 18.4 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Tmemb_185A PF10269.7 NM_001282302.1_3 - 1.3e-38 133.0 12.2 1.3e-38 133.0 12.2 1.5 2 0 0 2 2 2 1 Transmembrane Fragile-X-F protein TT_ORF2 PF02957.13 NM_001282302.1_3 - 0.39 11.5 3.0 0.63 10.8 3.0 1.2 1 0 0 1 1 1 0 TT viral ORF2 Tetraspannin PF00335.18 NM_001282302.1_3 - 5.8 6.5 9.5 0.28 10.9 4.1 1.5 2 0 0 2 2 2 0 Tetraspanin family ILEI PF15711.3 NM_058186.3_3 - 7.7e-27 93.5 0.1 1.4e-26 92.7 0.1 1.4 1 0 0 1 1 1 1 Interleukin-like EMT inducer GST_C_3 PF14497.4 NM_000852.3_1 - 2.3e-15 56.4 0.0 4.4e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 NM_000852.3_1 - 2.1e-13 50.1 0.0 4.2e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 NM_000852.3_1 - 3.7e-06 27.1 0.0 6.3e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 NM_000852.3_1 - 0.015 15.1 0.0 0.041 13.7 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SH2 PF00017.22 NM_001045557.2_3 - 3.5e-19 68.5 0.1 6.3e-19 67.7 0.1 1.4 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 NM_001045557.2_3 - 4.3e-05 22.9 0.0 8.4e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001045557.2_3 - 0.00023 20.8 0.4 0.0037 17.0 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain APP_E2 PF12925.5 NM_001136129.2_3 - 5.9e-74 247.8 20.3 9.5e-74 247.1 20.3 1.3 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein Beta-APP PF03494.11 NM_001136129.2_3 - 9.5e-27 92.4 1.7 1.6e-26 91.7 1.7 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) APP_Cu_bd PF12924.5 NM_001136129.2_3 - 2e-25 89.2 7.9 2.6e-25 88.8 4.7 2.8 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.7 NM_001136129.2_3 - 2.1e-25 88.9 0.3 9.2e-25 86.8 0.3 2.2 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus APP_N PF02177.14 NM_001136129.2_3 - 2.3e-21 75.9 1.1 4.6e-21 74.9 0.1 2.1 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding PI3K_1B_p101 PF10486.7 NM_001136129.2_3 - 0.008 13.9 11.6 0.012 13.3 11.6 1.1 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Mod_r PF07200.11 NM_001136129.2_3 - 0.33 10.9 11.0 0.041 13.9 5.8 2.1 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Activator-TraM PF11657.6 NM_001136129.2_3 - 0.89 9.2 6.5 2 8.1 6.5 1.5 1 0 0 1 1 1 0 Transcriptional activator TraM ELO PF01151.16 NM_001242828.1_3 - 3.8e-64 216.5 15.9 5.7e-64 215.9 15.9 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family NUDIX PF00293.26 NM_001301022.1_2 - 8e-16 58.1 0.6 1.3e-15 57.5 0.6 1.3 1 0 0 1 1 1 1 NUDIX domain zf-H2C2_2 PF13465.4 NM_183229.2_3 - 5.1e-10 39.2 8.9 3.6e-06 27.0 3.8 4.9 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.24 NM_183229.2_3 - 7.3e-07 29.2 33.3 7.1e-05 22.9 0.4 5.9 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_183229.2_3 - 0.00012 22.5 30.7 0.0021 18.6 0.3 6.5 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_183229.2_3 - 0.0075 15.9 0.2 0.039 13.6 0.2 2.3 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 NM_183229.2_3 - 0.01 15.5 16.1 0.025 14.2 0.1 3.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 NM_183229.2_3 - 0.012 15.4 20.1 0.88 9.5 0.4 4.8 4 0 0 4 4 4 0 C2H2-type zinc finger AKAP95 PF04988.10 NM_183229.2_3 - 0.4 10.8 5.0 8.1 6.5 0.4 2.5 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) Beta-Casp PF10996.6 NM_001256463.1_2 - 1.1e-25 89.9 0.0 4.3e-25 88.0 0.0 2.0 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.10 NM_001256463.1_2 - 1.8e-17 62.8 0.0 3.7e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.3 NM_001256463.1_2 - 1.6e-10 40.6 0.0 5.3e-10 38.9 0.0 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.25 NM_001256463.1_2 - 0.034 14.0 0.1 5.9 6.7 0.1 2.3 1 1 1 2 2 2 0 Metallo-beta-lactamase superfamily Ldh_1_N PF00056.21 NM_144972.4_3 - 7e-47 158.9 0.2 9.7e-47 158.5 0.2 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 NM_144972.4_3 - 1.6e-22 80.1 0.0 2.4e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain UDPG_MGDP_dh_N PF03721.12 NM_144972.4_3 - 0.014 14.8 0.3 0.024 14.1 0.3 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glyco_hydro_4 PF02056.14 NM_144972.4_3 - 0.024 14.1 2.1 0.65 9.4 0.1 2.2 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase ThiF PF00899.19 NM_144972.4_3 - 0.18 11.0 0.1 0.29 10.3 0.1 1.2 1 0 0 1 1 1 0 ThiF family zf-H2C2_2 PF13465.4 NM_006718.4_3 - 7.1e-12 45.1 52.9 7.8e-05 22.8 3.7 8.8 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_006718.4_3 - 5.1e-11 42.3 64.2 0.0054 17.3 0.4 8.7 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_006718.4_3 - 8e-11 41.6 68.0 3.1e-05 24.0 0.5 7.7 9 0 0 9 9 9 6 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 NM_006718.4_3 - 0.004 17.3 24.7 0.55 10.5 4.6 6.6 5 1 1 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_006718.4_3 - 0.082 13.2 25.7 0.023 14.9 4.6 5.4 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_006718.4_3 - 1.3 8.7 29.8 1.5 8.5 2.0 6.1 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 NM_006718.4_3 - 3 8.1 22.1 2.1 8.6 5.2 3.4 1 1 2 3 3 3 0 C2H2-type zinc ribbon Gla PF00594.18 NM_024082.3_2 - 9.3e-20 70.4 9.2 1.9e-19 69.4 9.2 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain BTB PF00651.29 NM_001186.3_1 - 2.6e-24 85.4 0.2 4.7e-24 84.6 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain bZIP_Maf PF03131.15 NM_001186.3_1 - 5.4e-15 55.5 4.0 1.3e-14 54.3 4.0 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.19 NM_001186.3_1 - 9.2e-10 38.4 6.1 1.9e-09 37.3 6.1 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001186.3_1 - 1.9e-07 30.9 6.0 4.9e-07 29.6 6.0 1.6 1 0 0 1 1 1 1 Basic region leucine zipper Cep57_CLD_2 PF14197.4 NM_001186.3_1 - 0.022 14.7 1.3 0.047 13.7 1.3 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 zf-H2C2_2 PF13465.4 NM_207395.2_3 - 8.6e-62 202.9 48.4 9e-09 35.3 0.3 10.5 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_207395.2_3 - 7.4e-44 145.7 62.1 2.5e-06 27.5 0.8 10.4 10 0 0 10 10 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_207395.2_3 - 3.1e-26 89.6 60.0 0.0041 17.7 1.1 10.2 9 0 0 9 9 9 9 C2H2-type zinc finger KRAB PF01352.25 NM_207395.2_3 - 2.2e-23 81.5 0.4 3.7e-23 80.8 0.4 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_207395.2_3 - 8.7e-11 41.4 51.0 0.063 13.1 2.3 9.9 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_207395.2_3 - 3.1e-10 40.0 22.8 0.024 14.8 0.4 8.5 9 0 0 9 9 9 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_207395.2_3 - 3.7e-08 33.2 30.9 0.0016 18.4 2.3 6.3 5 2 2 7 7 7 4 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_207395.2_3 - 0.012 16.2 22.3 0.9 10.2 0.6 5.1 1 1 4 5 5 5 0 zinc-ribbon family ADK_lid PF05191.12 NM_207395.2_3 - 0.017 15.0 10.3 9 6.3 0.6 5.6 3 3 1 4 4 4 0 Adenylate kinase, active site lid LIM PF00412.20 NM_207395.2_3 - 0.098 12.8 34.0 1.7 8.8 1.7 6.6 3 2 2 6 6 6 0 LIM domain HypA PF01155.17 NM_207395.2_3 - 0.13 12.1 22.4 2.2 8.2 2.7 4.6 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HC_2 PF13913.4 NM_207395.2_3 - 0.25 11.2 23.6 0.076 12.8 0.4 6.4 6 0 0 6 6 6 0 zinc-finger of a C2HC-type BolA PF01722.16 NM_207395.2_3 - 0.36 11.0 11.1 0.74 10.0 0.5 4.6 3 2 1 4 4 4 0 BolA-like protein zf-C2H2_11 PF16622.3 NM_207395.2_3 - 0.61 9.8 55.1 0.18 11.4 1.7 9.3 9 0 0 9 9 9 0 zinc-finger C2H2-type GAGA PF09237.9 NM_207395.2_3 - 0.82 9.4 9.6 0.42 10.3 0.5 4.0 2 2 1 4 4 4 0 GAGA factor FYDLN_acid PF09538.8 NM_207395.2_3 - 0.93 10.1 13.9 23 5.6 0.2 6.1 2 2 4 6 6 6 0 Protein of unknown function (FYDLN_acid) Ta0938 PF11494.6 NM_207395.2_3 - 1.4 9.1 6.3 4.4 7.5 0.0 3.7 1 1 3 4 4 4 0 Ta0938 C1_4 PF07975.10 NM_207395.2_3 - 1.6 8.9 30.6 0.76 10.0 3.2 5.8 1 1 8 9 9 9 0 TFIIH C1-like domain zf-LYAR PF08790.9 NM_207395.2_3 - 4.3 7.2 33.3 3.2 7.6 0.0 8.1 9 0 0 9 9 9 0 LYAR-type C2HC zinc finger DUF3268 PF11672.6 NM_207395.2_3 - 6.3 7.0 18.4 12 6.1 0.1 4.4 1 1 5 7 7 7 0 zinc-finger-containing domain NUDE_C PF04880.11 NM_017668.2_2 - 4.4e-47 160.7 2.4 4.4e-47 160.7 2.4 3.2 3 0 0 3 3 3 1 NUDE protein, C-terminal conserved region TPR_MLP1_2 PF07926.10 NM_017668.2_2 - 0.065 13.2 33.5 0.042 13.8 9.8 3.3 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Lectin_N PF03954.12 NM_017668.2_2 - 0.12 11.9 5.8 0.11 12.1 3.4 2.2 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Pepsin-I3 PF06394.11 NM_017668.2_2 - 0.31 11.1 2.6 0.89 9.6 2.6 1.8 1 0 0 1 1 1 0 Pepsin inhibitor-3-like repeated domain ATG16 PF08614.9 NM_017668.2_2 - 0.73 9.8 37.7 2 8.4 20.9 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF972 PF06156.11 NM_017668.2_2 - 4.1 7.9 22.5 2.1 8.9 5.0 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF972) PspA_IM30 PF04012.10 NM_017668.2_2 - 7.6 5.9 31.3 0.42 10.0 5.7 3.5 2 1 1 3 3 3 0 PspA/IM30 family PRKG1_interact PF15898.3 NM_017668.2_2 - 8.8 7.2 27.9 0.054 14.3 10.6 2.9 1 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain FAST_1 PF06743.13 NM_030900.3_3 - 1.4e-23 82.5 2.9 1.2e-22 79.5 0.4 2.6 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 1 FAST_2 PF08368.10 NM_030900.3_3 - 7.1e-23 81.1 0.0 3e-22 79.1 0.0 2.2 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 RAP PF08373.8 NM_030900.3_3 - 9.8e-09 35.1 0.0 2.1e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 RAP domain FATC PF02260.18 NM_030900.3_3 - 0.0051 16.5 0.0 0.023 14.4 0.0 2.2 1 0 0 1 1 1 1 FATC domain LSR PF05624.12 NM_001260489.1_2 - 2.2e-23 81.8 37.4 4.4e-23 80.9 37.4 1.5 1 0 0 1 1 1 1 Lipolysis stimulated receptor (LSR) V-set PF07686.15 NM_001260489.1_2 - 0.00018 21.5 0.4 0.0032 17.5 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001260489.1_2 - 0.028 14.9 1.9 1.1 9.8 1.9 2.5 1 1 0 1 1 1 0 Immunoglobulin domain ig PF00047.23 NM_001260489.1_2 - 0.074 13.1 0.2 4.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin domain Reo_sigmaC PF04582.10 NM_001018090.6_3 - 0.2 10.9 10.4 0.28 10.4 1.2 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein PIP5K PF01504.16 NM_001135637.1_3 - 6.9e-92 307.4 0.0 8.9e-92 307.1 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase dCMP_cyt_deam_1 PF00383.21 NM_001012732.1_3 - 8.1e-28 96.1 0.1 1.4e-27 95.4 0.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 NM_001012732.1_3 - 1.8e-13 50.3 0.0 2.4e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Bombesin PF02044.15 NM_205858.1_3 - 1.7e-08 33.8 3.1 3.9e-08 32.6 3.1 1.7 1 0 0 1 1 1 1 Bombesin-like peptide Ank_2 PF12796.5 NM_001256183.1_3 - 4.9e-19 68.6 0.1 8e-10 39.1 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 NM_001256183.1_3 - 7.6e-17 60.8 0.0 0.00041 20.6 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.4 NM_001256183.1_3 - 3.3e-16 59.3 0.9 1.3e-07 31.9 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001256183.1_3 - 2e-15 56.5 0.2 2.3e-07 30.9 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001256183.1_3 - 1e-13 50.0 0.0 0.0019 18.4 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat MAGE PF01454.17 NM_001271183.1_2 - 5.9e-20 71.7 0.1 2.8e-18 66.2 0.1 2.1 1 1 0 1 1 1 1 MAGE family zf-RING_2 PF13639.4 NM_001323511.1_2 - 4.4e-12 45.9 6.9 4.4e-12 45.9 6.9 3.3 3 0 0 3 3 2 1 Ring finger domain CUE PF02845.14 NM_001323511.1_2 - 8.6e-10 38.0 0.1 2e-09 36.8 0.1 1.7 1 0 0 1 1 1 1 CUE domain zf-C3HC4_2 PF13923.4 NM_001323511.1_2 - 1.7e-09 37.2 6.2 1.7e-09 37.2 6.2 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001323511.1_2 - 2e-08 34.0 2.0 5.7e-08 32.5 2.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_001323511.1_2 - 4.8e-08 32.6 4.9 1.7e-07 30.8 4.9 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001323511.1_2 - 1.1e-06 28.2 3.2 1.1e-06 28.2 3.2 2.9 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 NM_001323511.1_2 - 1.2e-06 28.0 1.4 1.2e-06 28.0 1.4 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.5 NM_001323511.1_2 - 4.5e-06 26.7 11.0 8.2e-06 25.9 8.1 2.9 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 NM_001323511.1_2 - 2.3e-05 24.1 3.4 7e-05 22.6 3.4 1.9 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 NM_001323511.1_2 - 4.6e-05 23.1 4.2 4.6e-05 23.1 4.2 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 NM_001323511.1_2 - 4.8e-05 23.2 0.6 0.00016 21.5 0.6 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.3 NM_001323511.1_2 - 0.00022 20.6 4.8 0.00022 20.6 4.8 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.4 NM_001323511.1_2 - 0.0034 17.4 4.1 0.0094 16.0 4.1 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING F-box-like PF12937.5 NM_001316941.1_3 - 0.00047 19.9 0.4 0.00047 19.9 0.4 3.1 3 0 0 3 3 3 1 F-box-like F-box PF00646.31 NM_001316941.1_3 - 0.0014 18.3 0.6 0.0014 18.3 0.6 2.3 3 0 0 3 3 3 1 F-box domain zf-H2C2_2 PF13465.4 NM_001297623.2_2 - 1.2e-74 243.5 105.3 1.9e-08 34.2 1.1 14.6 13 1 0 13 13 13 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001297623.2_2 - 2.2e-40 134.8 125.4 4.1e-06 26.8 1.0 13.8 13 0 0 13 13 13 10 Zinc finger, C2H2 type KRAB PF01352.25 NM_001297623.2_2 - 4.1e-24 83.8 0.3 7.9e-24 82.9 0.3 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001297623.2_2 - 1.2e-07 31.8 132.5 0.017 15.8 5.1 14.3 14 0 0 14 14 14 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001297623.2_2 - 4.4e-05 23.2 97.4 0.0068 16.2 0.3 12.9 13 0 0 13 13 13 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001297623.2_2 - 6.9e-05 22.7 72.9 0.0046 16.9 3.7 8.3 4 2 6 10 10 10 7 Zinc ribbon domain BHD_1 PF10403.7 NM_001297623.2_2 - 3.9 7.2 6.0 51 3.7 1.0 4.3 4 1 0 4 4 4 0 Rad4 beta-hairpin domain 1 RIC1 PF07064.11 NM_001135920.2_3 - 2.3e-81 272.8 1.1 3.5e-81 272.2 1.1 1.3 1 0 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.5 NM_001135920.2_3 - 1.7e-06 28.1 0.0 1.9 8.7 0.0 4.6 3 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain CHDCT2 PF08074.9 NM_001005273.2_1 - 1.3e-90 302.0 0.9 2.8e-90 300.9 0.9 1.6 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF1086 PF06461.9 NM_001005273.2_1 - 7.5e-62 207.1 0.0 2.4e-61 205.5 0.0 1.9 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.21 NM_001005273.2_1 - 2.8e-61 207.0 0.0 7e-61 205.7 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain CHDNT PF08073.10 NM_001005273.2_1 - 2.5e-26 91.2 0.4 6.1e-26 90.0 0.4 1.7 1 0 0 1 1 1 1 CHDNT (NUC034) domain DUF1087 PF06465.11 NM_001005273.2_1 - 6.1e-25 86.9 6.6 6.1e-25 86.9 6.6 2.9 3 0 0 3 3 1 1 Domain of Unknown Function (DUF1087) Helicase_C PF00271.29 NM_001005273.2_1 - 1.2e-21 77.0 0.0 2.2e-21 76.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 NM_001005273.2_1 - 3e-20 71.7 26.4 1.7e-10 40.5 7.3 2.5 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.22 NM_001005273.2_1 - 2.9e-19 68.6 6.8 8.6e-14 51.0 2.5 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 NM_001005273.2_1 - 1.6e-08 34.6 0.0 5e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 NM_001005273.2_1 - 4.4e-08 32.5 0.0 1.2e-07 31.1 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 HMG_box PF00505.17 NM_001005273.2_1 - 0.0034 17.6 0.2 0.0034 17.6 0.2 2.3 2 0 0 2 2 1 1 HMG (high mobility group) box DEAD PF00270.27 NM_001005273.2_1 - 0.0052 16.4 0.0 0.019 14.6 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase PHD_2 PF13831.4 NM_001005273.2_1 - 0.048 13.1 11.5 0.27 10.7 3.1 2.7 2 0 0 2 2 2 0 PHD-finger AAA_22 PF13401.4 NM_001005273.2_1 - 0.11 12.6 0.1 0.47 10.6 0.0 2.2 2 0 0 2 2 1 0 AAA domain DUF3140 PF11338.6 NM_001005273.2_1 - 0.13 12.6 1.2 0.46 10.8 1.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) zf-PHD-like PF15446.4 NM_001005273.2_1 - 4.9 6.6 16.4 0.98 8.9 0.7 3.2 1 1 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Myosin_head PF00063.19 NM_001303279.1_2 - 1.4e-242 806.7 9.7 1.6e-242 806.4 9.7 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 NM_001303279.1_2 - 1.4e-39 135.6 0.1 2.8e-39 134.6 0.1 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 NM_001303279.1_2 - 0.00019 20.8 7.8 0.015 14.9 1.1 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif AAA_18 PF13238.4 NM_001303279.1_2 - 0.04 14.3 0.0 0.14 12.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.10 NM_001303279.1_2 - 0.041 13.0 0.0 0.084 12.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.4 NM_001303279.1_2 - 0.055 13.6 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.24 NM_001303279.1_2 - 0.076 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.4 NM_001303279.1_2 - 0.12 12.6 0.0 0.34 11.1 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Lactamase_B_6 PF16661.3 NM_002373.5_3 - 0.027 13.8 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Y_Y_Y PF07495.11 NM_001168377.1_1 - 1.9e-13 50.0 0.1 0.02 14.7 0.0 5.3 5 0 0 5 5 5 3 Y_Y_Y domain REJ PF02010.13 NM_001168377.1_1 - 3.2e-13 49.2 4.7 1.8e-06 26.9 0.0 3.5 1 1 2 3 3 3 3 REJ domain PKD PF00801.18 NM_001168377.1_1 - 6.7e-11 41.8 9.6 0.083 12.6 0.1 5.5 5 0 0 5 5 5 4 PKD domain DUF4625 PF15418.4 NM_001168377.1_1 - 9.2e-08 32.3 0.1 1.2 9.3 0.0 4.3 4 0 0 4 4 4 2 Domain of unknown function (DUF4625) He_PIG PF05345.10 NM_001168377.1_1 - 1.4e-05 25.0 5.5 2.3 8.4 0.0 5.6 5 0 0 5 5 5 2 Putative Ig domain DUF5013 PF16405.3 NM_001168377.1_1 - 0.001 19.2 0.3 1.5 9.0 0.0 4.3 4 1 1 5 5 5 1 Domain of unknown function (DUF5013) Wzt_C PF14524.4 NM_001168377.1_1 - 0.0011 18.9 0.0 1.8 8.4 0.0 3.9 4 0 0 4 4 4 1 Wzt C-terminal domain Cadherin PF00028.15 NM_001168377.1_1 - 0.0018 18.6 4.9 17 5.8 0.1 4.4 4 0 0 4 4 4 0 Cadherin domain DUF5011 PF16403.3 NM_001168377.1_1 - 0.002 18.1 2.7 16 5.6 0.1 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) DUF4998 PF16389.3 NM_001168377.1_1 - 0.0021 17.5 0.2 6.3 6.2 0.0 3.8 3 1 1 4 4 4 1 Domain of unknown function Big_3_2 PF12245.6 NM_001168377.1_1 - 0.051 13.2 0.1 3.5 7.3 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) OCIA PF07051.9 NM_017830.3_3 - 2.1e-37 126.9 0.0 3.3e-37 126.2 0.0 1.3 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) Gal-bind_lectin PF00337.20 NM_001042685.1_3 - 1.4e-75 251.1 0.6 1.1e-36 125.2 0.0 2.1 2 0 0 2 2 2 2 Galactoside-binding lectin V_ATPase_I PF01496.17 NM_005177.3_3 - 0 1125.2 0.1 0 1124.8 0.1 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Pkinase PF00069.23 NM_001161564.2_1 - 2.2e-64 217.3 0.0 4.3e-64 216.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.20 NM_001161564.2_1 - 5.8e-60 203.1 0.0 8.5e-60 202.6 0.0 1.2 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 NM_001161564.2_1 - 1.1e-47 162.4 0.0 1.6e-47 161.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase A_deaminase PF00962.20 NM_139156.3_1 - 3.3e-134 447.2 1.2 5.1e-134 446.6 1.2 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase 7tm_1 PF00001.19 NM_001098200.1_1 - 1.1e-32 113.2 21.2 1.9e-32 112.5 21.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4513 PF14983.4 NM_207408.1_2 - 1.6e-81 270.8 0.1 1.9e-81 270.6 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4513) Sec2p PF06428.9 NM_175624.3_3 - 5.2e-08 32.6 8.9 5.7e-08 32.5 7.7 1.7 1 1 0 1 1 1 1 GDP/GTP exchange factor Sec2p APG6 PF04111.10 NM_175624.3_3 - 0.096 11.9 5.1 0.15 11.3 5.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 THAP PF05485.10 NM_001317776.1_1 - 2.4e-15 57.1 0.8 7e-14 52.4 0.0 2.8 2 0 0 2 2 2 1 THAP domain Tnp_P_element PF12017.6 NM_001317776.1_1 - 5.7e-08 32.3 0.1 1.3e-07 31.2 0.1 1.6 1 0 0 1 1 1 1 Transposase protein Metallophos PF00149.26 NM_206876.1_2 - 4.5e-38 131.7 0.1 6.1e-38 131.2 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 NM_206876.1_2 - 1.2e-19 70.3 0.5 2.3e-19 69.4 0.5 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain FOP_dimer PF09398.8 NM_025139.5_3 - 0.093 12.9 0.1 0.53 10.4 0.0 2.4 2 0 0 2 2 2 0 FOP N terminal dimerisation domain CENP-B_dimeris PF09026.8 NM_025139.5_3 - 0.34 11.2 7.2 0.15 12.3 4.4 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain AP3D1 PF06375.9 NM_025139.5_3 - 1.1 9.4 6.0 2 8.6 6.0 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 HR1 PF02185.14 NM_025139.5_3 - 8.1 6.5 7.8 3.6 7.6 2.4 2.8 3 0 0 3 3 3 0 Hr1 repeat LIM PF00412.20 NM_001318899.1_2 - 3.3e-41 139.2 56.7 4.4e-12 45.9 8.6 4.7 5 0 0 5 5 5 4 LIM domain zf-ribbon_3 PF13248.4 NM_001318899.1_2 - 0.11 11.8 0.2 0.11 11.8 0.2 5.6 6 1 0 6 6 6 0 zinc-ribbon domain Methyltransf_11 PF08241.10 NM_014033.3_1 - 3.5e-20 72.3 0.0 5.3e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 NM_014033.3_1 - 9e-16 58.1 0.0 1.4e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_014033.3_1 - 1.6e-13 51.1 0.0 2.5e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_014033.3_1 - 1e-11 45.2 0.0 1.6e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_014033.3_1 - 1.8e-11 43.9 0.0 2.6e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 NM_014033.3_1 - 1.6e-07 30.8 0.0 2.3e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.13 NM_014033.3_1 - 6.4e-05 22.8 0.0 0.0001 22.1 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase NodS PF05401.9 NM_014033.3_1 - 0.0014 18.1 0.0 0.0022 17.5 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) CheR PF01739.16 NM_014033.3_1 - 0.11 11.9 0.1 0.55 9.5 0.0 1.9 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain Tektin PF03148.12 NM_144705.3_1 - 1.8e-132 441.6 40.7 2e-132 441.4 40.7 1.0 1 0 0 1 1 1 1 Tektin family Med9 PF07544.11 NM_144705.3_1 - 0.18 11.7 0.2 0.18 11.7 0.2 3.8 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 ParD_antitoxin PF03693.12 NM_144705.3_1 - 0.3 11.4 1.8 26 5.2 0.1 2.8 2 0 0 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Cas6 PF09559.8 NM_144705.3_1 - 0.43 10.4 7.1 0.57 10.0 0.9 2.3 2 0 0 2 2 2 0 Cas6 Crispr Prefoldin_2 PF01920.18 NM_144705.3_1 - 0.6 10.0 14.0 0.17 11.7 3.3 3.3 3 0 0 3 3 3 0 Prefoldin subunit NEP PF10167.7 NM_144705.3_1 - 1 9.2 8.8 12 5.8 0.8 3.5 3 0 0 3 3 3 0 Uncharacterised conserved protein KH_1 PF00013.27 NM_001320967.1_1 - 2.5e-183 594.1 58.7 2.8e-15 55.8 0.8 16.1 15 1 0 15 15 15 15 KH domain SLS PF14611.4 NM_001320967.1_1 - 3.9e-18 66.0 17.3 3.3e-05 23.7 0.4 8.5 3 3 3 8 8 8 6 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.15 NM_001320967.1_1 - 9e-18 63.7 33.0 0.0057 16.3 0.2 12.3 11 1 0 12 12 12 7 KH domain KH_5 PF13184.4 NM_001320967.1_1 - 1.3e-07 31.4 20.8 1.5 8.8 0.3 10.3 11 0 0 11 11 11 3 NusA-like KH domain BMC PF00936.17 NM_001320967.1_1 - 0.0015 18.4 0.1 1e+02 2.8 0.0 6.4 7 0 0 7 7 7 0 BMC domain DUF4530 PF15039.4 NM_001320967.1_1 - 0.025 14.6 0.0 14 5.7 0.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4530) DUF2096 PF09869.7 NM_001320967.1_1 - 0.58 10.1 16.0 8 6.4 0.4 6.4 6 2 0 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2096) DUF2067 PF09840.7 NM_001320967.1_1 - 2.9 7.3 13.0 0.24 10.8 0.2 4.7 6 0 0 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2067) Neur_chan_LBD PF02931.21 NM_001161772.2_2 - 1.1e-55 188.2 5.3 1.6e-55 187.8 5.3 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_001161772.2_2 - 5.7e-41 141.0 0.1 1.2e-40 140.0 0.1 1.5 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region BTD PF09270.8 NM_005349.3_3 - 4.2e-74 247.7 0.0 7.1e-74 247.0 0.0 1.4 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.9 NM_005349.3_3 - 2.8e-50 170.8 0.9 2.8e-50 170.8 0.9 1.8 2 0 0 2 2 2 1 LAG1, DNA binding TIG PF01833.22 NM_005349.3_3 - 0.003 17.5 0.0 0.0082 16.1 0.0 1.7 1 0 0 1 1 1 1 IPT/TIG domain CSD PF00313.20 NM_014316.3_1 - 2.7e-11 43.0 0.0 5.4e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.9 NM_014316.3_1 - 0.067 12.8 0.1 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 Ribonuclease B OB domain DUF4339 PF14237.4 NM_014316.3_2 - 0.058 13.1 0.1 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4339) PqqA PF08042.9 NM_001323947.1_2 - 0.68 9.9 2.2 7.1 6.7 0.0 2.8 3 0 0 3 3 3 0 PqqA family zf-CXXC PF02008.18 NM_001323947.1_3 - 2.3e-29 101.0 73.4 4.1e-13 49.0 26.0 5.0 5 1 0 5 5 5 3 CXXC zinc finger domain MBD PF01429.17 NM_001323947.1_3 - 2.5e-16 59.0 0.0 7.3e-16 57.5 0.0 1.8 1 0 0 1 1 1 1 Methyl-CpG binding domain MOZ_SAS PF01853.16 NM_001256468.1_3 - 3.5e-82 274.2 0.3 6.7e-82 273.3 0.3 1.5 1 0 0 1 1 1 1 MOZ/SAS family PHD PF00628.27 NM_001256468.1_3 - 4.3e-17 61.6 26.6 8.5e-11 41.5 7.9 3.4 2 1 1 3 3 3 2 PHD-finger Linker_histone PF00538.17 NM_001256468.1_3 - 2.2e-08 34.2 0.0 0.00016 21.8 0.0 2.5 2 0 0 2 2 2 2 linker histone H1 and H5 family Acetyltransf_7 PF13508.5 NM_001256468.1_3 - 0.012 15.9 0.0 0.064 13.6 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PHD_2 PF13831.4 NM_001256468.1_3 - 0.042 13.2 13.1 0.054 12.9 2.7 3.0 2 0 0 2 2 2 0 PHD-finger zf-H2C2_2 PF13465.4 NM_001260487.1_1 - 2.4e-75 245.7 95.3 3.7e-08 33.3 1.8 14.2 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001260487.1_1 - 7.6e-47 155.1 103.1 1.1e-05 25.5 1.8 14.0 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001260487.1_1 - 2.2e-26 90.1 96.3 0.0013 19.3 0.8 14.0 14 0 0 14 14 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_001260487.1_1 - 6.5e-23 80.0 0.1 6.5e-23 80.0 0.1 1.9 2 0 0 2 2 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001260487.1_1 - 2.7e-15 56.1 61.3 0.0047 17.1 0.2 12.0 13 0 0 13 13 13 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001260487.1_1 - 2.1e-08 33.8 81.1 0.031 14.1 0.6 12.6 13 0 0 13 13 13 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001260487.1_1 - 7.8e-07 29.0 68.3 0.058 13.4 1.5 9.7 3 3 7 11 11 11 6 Zinc ribbon domain zf-met PF12874.5 NM_001260487.1_1 - 0.00035 20.7 79.3 0.051 13.9 1.3 11.6 13 0 0 13 13 13 5 Zinc-finger of C2H2 type DUF3268 PF11672.6 NM_001260487.1_1 - 0.0005 20.3 38.7 0.087 13.0 0.2 6.5 5 1 0 6 6 6 3 zinc-finger-containing domain BolA PF01722.16 NM_001260487.1_1 - 0.017 15.3 15.0 1.9 8.7 0.2 4.7 3 2 2 5 5 5 0 BolA-like protein ADK_lid PF05191.12 NM_001260487.1_1 - 0.019 14.8 57.5 0.044 13.7 0.5 9.9 8 2 0 8 8 8 0 Adenylate kinase, active site lid XPA_N PF01286.16 NM_001260487.1_1 - 0.36 10.8 66.3 6.6 6.7 0.4 13.3 13 0 0 13 13 13 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001260487.1_1 - 0.8 10.4 54.2 1.2 9.8 1.5 7.4 1 1 5 8 8 8 0 zinc-ribbon family zf-trcl PF13451.4 NM_001260487.1_1 - 8.5 6.2 68.7 2.3 8.1 0.4 12.0 9 4 0 9 9 9 0 Probable zinc-ribbon domain HpcH_HpaI PF03328.12 NM_206808.3_3 - 2.6e-48 163.9 0.0 3.4e-48 163.5 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.4 NM_206808.3_3 - 2.3e-10 40.0 0.0 2e-05 23.8 0.0 2.2 1 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold Pkinase_Tyr PF07714.15 NM_004103.4_2 - 3.9e-93 311.4 0.0 6.2e-93 310.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.11 NM_004103.4_2 - 2e-52 176.5 1.9 3.8e-52 175.6 1.9 1.5 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.23 NM_004103.4_2 - 1.3e-42 145.9 0.0 2.2e-42 145.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 NM_004103.4_2 - 5.4e-12 46.0 1.4 1.8e-11 44.4 1.4 1.8 1 0 0 1 1 1 1 FERM central domain WD40 PF00400.30 NM_001308007.1_1 - 2.2e-10 40.8 8.7 2.4e-05 24.8 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.6 NM_001308007.1_1 - 0.013 14.0 0.0 0.028 12.9 0.0 1.5 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ank_2 PF12796.5 NM_004556.2_2 - 2.1e-22 79.3 4.1 6.1e-12 45.8 0.1 2.8 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 NM_004556.2_2 - 1.2e-17 63.4 11.2 0.0034 17.6 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.4 NM_004556.2_2 - 6.6e-17 61.5 4.5 4e-05 23.9 1.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_004556.2_2 - 9.9e-15 53.1 6.6 0.2 12.2 0.0 6.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.4 NM_004556.2_2 - 7.1e-14 51.6 10.6 4.9e-05 23.4 0.6 4.6 2 1 2 5 5 5 4 Ankyrin repeats (many copies) tRNA_Me_trans PF03054.14 NM_001282783.1_1 - 9.9e-70 234.9 0.0 1.3e-69 234.6 0.0 1.1 1 0 0 1 1 1 1 tRNA methyl transferase tRNA_Me_trans PF03054.14 NM_001282783.1_2 - 5e-30 104.4 0.1 6.7e-30 103.9 0.1 1.1 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.12 NM_001282783.1_2 - 5.2e-06 26.1 0.0 7.4e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) NAD_synthase PF02540.15 NM_001282783.1_2 - 0.0002 20.5 0.0 0.00029 19.9 0.0 1.1 1 0 0 1 1 1 1 NAD synthase Asn_synthase PF00733.19 NM_001282783.1_2 - 0.012 15.1 0.0 0.017 14.7 0.0 1.1 1 0 0 1 1 1 0 Asparagine synthase QueC PF06508.11 NM_001282783.1_2 - 0.033 13.6 0.0 0.046 13.1 0.0 1.1 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.14 NM_001282783.1_3 - 0.063 11.9 0.0 0.091 11.4 0.0 1.1 1 0 0 1 1 1 0 tRNA methyl transferase PAP_central PF04928.15 NM_020144.4_2 - 1.3e-114 381.3 0.0 1.8e-114 380.8 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.13 NM_020144.4_2 - 2.5e-25 88.9 0.7 2.5e-19 69.4 0.1 2.3 1 1 1 2 2 2 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.21 NM_020144.4_2 - 5.9e-13 48.8 0.1 1.1e-12 47.9 0.1 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain TTC5_OB PF16669.3 NM_138376.2_1 - 6.7e-40 135.2 0.0 1.1e-39 134.6 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat protein 5 OB fold domain TPR_11 PF13414.4 NM_138376.2_1 - 6.3e-09 35.3 2.1 5.6e-05 22.6 0.0 3.9 3 1 1 4 4 4 1 TPR repeat TPR_2 PF07719.15 NM_138376.2_1 - 3.1e-07 29.9 12.3 0.0018 18.1 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_138376.2_1 - 8.5e-07 29.4 5.2 0.0011 19.4 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_138376.2_1 - 1.9e-06 27.3 10.4 0.037 13.7 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_138376.2_1 - 0.0003 21.1 0.8 0.04 14.3 0.0 3.1 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_17 PF13431.4 NM_138376.2_1 - 0.00052 20.1 0.3 0.056 13.7 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_138376.2_1 - 0.0038 17.8 1.5 0.78 10.6 0.0 3.7 2 2 2 4 4 4 2 Tetratricopeptide repeat Abi_C PF14355.4 NM_138376.2_1 - 0.0054 16.7 0.1 5.6 7.0 0.0 3.1 3 0 0 3 3 3 1 Abortive infection C-terminus TPR_8 PF13181.4 NM_138376.2_1 - 0.0056 16.7 8.8 0.031 14.3 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat Sec16_C PF12931.5 NM_138376.2_1 - 0.0074 15.8 0.1 0.014 14.9 0.1 1.4 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 TPR_9 PF13371.4 NM_138376.2_1 - 0.0089 16.0 0.9 0.56 10.3 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat RPN7 PF10602.7 NM_138376.2_1 - 0.021 14.3 0.1 0.058 12.9 0.1 1.6 1 1 0 1 1 1 0 26S proteasome subunit RPN7 TPR_12 PF13424.4 NM_138376.2_1 - 0.022 14.9 4.0 0.16 12.1 0.0 3.2 3 2 0 3 3 2 0 Tetratricopeptide repeat NARP1 PF12569.6 NM_138376.2_1 - 0.028 13.2 0.1 0.064 12.0 0.0 1.5 1 1 0 1 1 1 0 NMDA receptor-regulated protein 1 Serine_rich PF08824.8 NM_138376.2_1 - 0.049 13.5 0.2 0.12 12.2 0.2 1.7 1 0 0 1 1 1 0 Serine rich protein interaction domain Synaptonemal_3 PF15191.4 NM_138376.2_1 - 0.096 12.3 0.2 0.25 11.0 0.2 1.7 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 CDH-cyt PF16010.3 NM_138376.2_2 - 0.096 12.2 0.2 0.18 11.4 0.2 1.3 1 0 0 1 1 1 0 Cytochrome domain of cellobiose dehydrogenase SSB PF00436.23 NM_001256512.1_2 - 8.2e-31 106.0 0.1 1.1e-30 105.6 0.1 1.2 1 0 0 1 1 1 1 Single-strand binding protein family IFT20 PF14931.4 NM_001267774.1_3 - 2e-49 166.5 9.7 2.7e-49 166.2 9.7 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 HRDC PF00570.21 NM_001267774.1_3 - 0.12 12.2 0.9 0.22 11.4 0.9 1.3 1 0 0 1 1 1 0 HRDC domain DUF3135 PF11333.6 NM_001267774.1_3 - 1.9 8.6 7.1 3.7 7.7 3.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3135) Sas10 PF09368.8 NM_020368.2_2 - 2e-27 95.3 12.5 2e-27 95.3 12.5 2.2 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.13 NM_020368.2_2 - 5.1e-17 62.1 0.5 1.3e-16 60.8 0.0 2.0 2 0 0 2 2 2 1 Sas10/Utp3/C1D family START PF01852.17 NM_020151.3_3 - 1.6e-17 63.5 1.6 2.8e-17 62.7 1.6 1.3 1 0 0 1 1 1 1 START domain PX PF00787.22 NM_001300928.1_1 - 1.3e-11 44.3 0.1 2.1e-11 43.7 0.1 1.2 1 0 0 1 1 1 1 PX domain Pkinase_Tyr PF07714.15 NM_005248.2_1 - 7.2e-89 297.4 0.0 9e-89 297.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_005248.2_1 - 5.1e-41 140.6 0.0 7.2e-41 140.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 NM_005248.2_1 - 9.5e-28 96.0 0.1 1.9e-27 95.0 0.1 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 NM_005248.2_1 - 3.3e-19 68.1 0.1 1e-18 66.5 0.0 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 NM_005248.2_1 - 3e-12 46.1 0.0 6.4e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_005248.2_1 - 4.3e-10 39.0 0.0 1.1e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain DUF837 PF05769.9 NM_001171887.1_3 - 3.1e-75 252.0 25.3 3.9e-75 251.6 25.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF837) Tho2 PF11262.6 NM_001171887.1_3 - 0.066 12.3 8.7 0.0085 15.2 4.7 1.5 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 CAP PF00188.24 NM_153370.2_2 - 1.1e-19 71.4 0.6 1.8e-19 70.6 0.6 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Septin PF00735.16 NM_001321500.1_2 - 2.4e-96 322.1 1.8 3.9e-96 321.4 1.8 1.3 1 0 0 1 1 1 1 Septin AAA_22 PF13401.4 NM_001321500.1_2 - 0.0011 19.1 0.5 0.0057 16.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.21 NM_001321500.1_2 - 0.0017 18.3 0.0 0.0031 17.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.11 NM_001321500.1_2 - 0.0022 18.1 0.0 0.0041 17.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_001321500.1_2 - 0.0025 18.1 0.0 0.0056 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 NM_001321500.1_2 - 0.0086 15.9 0.1 0.38 10.5 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_001321500.1_2 - 0.024 14.1 0.2 3.9 6.8 0.1 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.4 NM_001321500.1_2 - 0.071 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Atg14 PF10186.7 NM_001321500.1_2 - 0.15 11.0 7.9 0.25 10.2 7.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_11 PF13086.4 NM_001321500.1_2 - 9.1 5.8 6.7 14 5.2 6.7 1.2 1 0 0 1 1 1 0 AAA domain ATP-gua_Ptrans PF00217.17 NM_001099736.1_2 - 2.8e-93 311.9 0.0 3.5e-93 311.6 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 NM_001099736.1_2 - 1e-32 112.2 0.0 1.7e-32 111.5 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain TPR_2 PF07719.15 NM_033028.4_2 - 2.3e-38 127.1 19.8 4.3e-05 23.2 0.0 10.0 10 0 0 10 10 9 9 Tetratricopeptide repeat TPR_1 PF00515.26 NM_033028.4_2 - 1.4e-34 116.4 24.9 2.8e-05 23.6 0.0 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.4 NM_033028.4_2 - 2e-28 96.0 22.0 5.1e-06 26.2 0.0 9.7 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_11 PF13414.4 NM_033028.4_2 - 1e-23 82.6 17.4 5.6e-09 35.4 0.0 7.9 3 2 7 10 10 10 5 TPR repeat TPR_19 PF14559.4 NM_033028.4_2 - 1.2e-20 73.6 10.9 3.5e-06 27.3 0.1 5.8 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.4 NM_033028.4_2 - 1.5e-17 63.5 17.9 2.9e-06 27.4 0.2 6.8 5 1 2 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.4 NM_033028.4_2 - 6.8e-16 58.5 0.4 0.038 14.6 0.4 5.9 3 2 5 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.4 NM_033028.4_2 - 1.2e-15 56.7 1.6 0.00091 19.7 0.0 7.1 3 3 5 8 8 7 3 Tetratricopeptide repeat TPR_17 PF13431.4 NM_033028.4_2 - 8.8e-15 53.8 16.4 0.0053 16.9 0.0 9.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_033028.4_2 - 4.7e-14 52.2 0.0 5.3e-05 23.2 0.0 5.1 2 2 3 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_033028.4_2 - 9.9e-14 51.2 26.6 7.1e-05 22.8 1.4 6.0 2 2 4 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.4 NM_033028.4_2 - 8e-10 37.9 12.1 0.0019 18.0 0.0 8.4 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_033028.4_2 - 2.1e-09 37.3 13.6 2.9 8.6 0.0 9.4 10 0 0 10 10 9 1 Tetratricopeptide repeat Wzy_C_2 PF11846.6 NM_033028.4_2 - 2e-06 27.7 3.2 0.14 11.9 0.0 4.1 2 2 2 4 4 4 2 Virulence factor membrane-bound polymerase, C-terminal PknG_TPR PF16918.3 NM_033028.4_2 - 3.4e-06 25.9 0.9 0.035 12.7 0.1 2.7 2 1 1 3 3 3 2 Protein kinase G tetratricopeptide repeat TPR_15 PF13429.4 NM_033028.4_2 - 7e-06 25.3 6.6 0.0097 15.0 0.0 3.8 1 1 2 3 3 3 3 Tetratricopeptide repeat NARP1 PF12569.6 NM_033028.4_2 - 2.6e-05 23.2 6.4 0.0096 14.7 0.2 3.8 2 1 3 5 5 5 1 NMDA receptor-regulated protein 1 TPR_20 PF14561.4 NM_033028.4_2 - 0.0039 17.3 5.0 0.65 10.2 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat ChAPs PF09295.8 NM_033028.4_2 - 0.016 14.1 1.1 0.8 8.5 0.1 2.7 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF3808 PF10300.7 NM_033028.4_2 - 0.037 12.6 5.8 0.071 11.7 0.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3808) TPR_10 PF13374.4 NM_033028.4_2 - 0.042 13.6 20.8 8.3 6.3 0.1 7.4 8 0 0 8 8 7 0 Tetratricopeptide repeat BTAD PF03704.15 NM_033028.4_2 - 0.043 14.1 5.5 14 5.9 1.6 3.9 3 1 1 4 4 4 0 Bacterial transcriptional activator domain Mu-like_Pro PF10123.7 NM_033028.4_2 - 0.049 13.0 1.0 0.25 10.7 0.0 2.0 1 1 0 2 2 2 0 Mu-like prophage I protein Coatomer_E PF04733.12 NM_033028.4_2 - 0.2 10.9 7.2 3.1 7.0 0.3 3.4 2 2 0 3 3 3 0 Coatomer epsilon subunit Fis1_TPR_C PF14853.4 NM_033028.4_2 - 1.7 8.6 4.4 7.7 6.5 0.0 3.8 4 1 1 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat MIP PF00230.18 NM_001650.5_3 - 5.6e-71 238.7 17.0 8.1e-71 238.2 17.0 1.2 1 0 0 1 1 1 1 Major intrinsic protein 7tm_4 PF13853.4 NM_001004475.1_1 - 1.9e-49 168.8 21.2 2.2e-49 168.5 21.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004475.1_1 - 2.9e-16 59.4 22.1 9.2e-16 57.7 22.1 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Neur_chan_memb PF02932.14 NM_000742.3_1 - 1e-93 313.7 0.0 1.4e-93 313.3 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 NM_000742.3_1 - 1e-79 266.8 2.4 1.3e-79 266.5 2.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.7 NM_000742.3_1 - 3.1 7.0 9.6 2.9 7.1 8.1 1.6 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Siva PF05458.10 NM_006427.3_1 - 3.8e-93 309.8 10.5 5.1e-93 309.4 10.5 1.2 1 0 0 1 1 1 1 Cd27 binding protein (Siva) IL28A PF15177.4 NM_172138.1_2 - 4.8e-75 250.5 3.7 5.9e-75 250.3 3.7 1.1 1 0 0 1 1 1 1 Interleukin-28A 7tm_1 PF00001.19 NM_207364.2_2 - 1.3e-14 54.0 12.2 2.4e-14 53.1 12.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF641 PF04859.10 NM_182603.3_2 - 0.11 12.7 0.9 0.15 12.2 0.9 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) BST2 PF16716.3 NM_182603.3_2 - 0.23 11.9 2.1 0.36 11.3 2.1 1.3 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 HR1 PF02185.14 NM_182603.3_2 - 0.31 11.1 2.3 0.53 10.3 2.3 1.3 1 0 0 1 1 1 0 Hr1 repeat Prefoldin_2 PF01920.18 NM_182603.3_2 - 0.75 9.7 2.8 1.1 9.1 2.8 1.1 1 0 0 1 1 1 0 Prefoldin subunit Ank_2 PF12796.5 NM_182603.3_3 - 4.7e-35 119.9 0.5 2.8e-12 46.9 0.0 3.9 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_182603.3_3 - 3.1e-34 116.8 11.1 3.5e-09 36.9 0.2 5.6 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_182603.3_3 - 9e-27 92.6 2.9 2e-08 34.3 0.0 4.9 2 2 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 NM_182603.3_3 - 9.4e-23 79.5 6.8 0.00018 21.7 0.1 7.3 8 0 0 8 8 8 5 Ankyrin repeat Ank_3 PF13606.4 NM_182603.3_3 - 5.6e-19 66.1 2.7 0.00059 20.0 0.0 7.1 8 0 0 8 8 8 5 Ankyrin repeat Ion_trans PF00520.29 NM_021098.2_3 - 2.8e-256 845.3 65.7 1.1e-79 267.1 12.1 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.10 NM_021098.2_3 - 2.3e-15 56.1 77.7 9.8e-10 37.5 1.2 9.7 5 4 4 9 9 9 6 Polycystin cation channel DUF788 PF05620.9 NM_021098.2_3 - 0.15 11.8 4.0 1.6 8.5 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF788) DUF4834 PF16118.3 NM_021098.2_3 - 0.27 12.1 9.7 8.6 7.3 0.1 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) ECSCR PF15820.3 NM_021098.2_3 - 0.31 10.7 1.1 5.4 6.8 0.1 3.4 3 0 0 3 3 3 0 Endothelial cell-specific chemotaxis regulator NicO PF03824.14 NM_021098.2_3 - 0.61 9.2 11.1 0.25 10.5 2.0 3.9 3 1 0 3 3 3 0 High-affinity nickel-transport protein RhoGEF PF00621.18 NM_001047160.2_2 - 7.4e-36 124.0 0.0 1.2e-35 123.3 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 NM_001047160.2_2 - 6.8e-08 32.8 0.0 1.5e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_5 PF15405.4 NM_001047160.2_2 - 4.2e-07 30.0 0.0 1.1e-06 28.6 0.0 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.3 NM_001047160.2_2 - 1e-06 28.6 0.0 3.6e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.3 NM_001047160.2_2 - 0.045 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 PH domain Tubulin PF00091.23 NM_001293212.1_1 - 9.9e-59 198.7 0.0 1.6e-58 198.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_001293212.1_1 - 9.1e-42 142.1 0.1 1.4e-41 141.5 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 NM_001293212.1_1 - 0.02 14.4 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 NM_001293212.1_1 - 0.045 12.8 0.0 0.078 12.0 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Sec23_trunk PF04811.13 NM_032986.3_3 - 1.5e-79 266.9 0.0 2.2e-79 266.3 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.10 NM_032986.3_3 - 8.7e-32 109.6 0.0 1.9e-31 108.6 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.13 NM_032986.3_3 - 1.6e-25 88.7 0.1 3.9e-25 87.5 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.20 NM_032986.3_3 - 1.2e-16 60.3 0.0 2.8e-16 59.0 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.13 NM_032986.3_3 - 3.5e-15 55.6 5.9 7.9e-15 54.5 5.9 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger zf-RING_UBOX PF13445.4 NM_001302694.1_1 - 4.8e-11 42.3 6.1 4.8e-11 42.3 6.1 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_001302694.1_1 - 7e-09 35.3 10.7 1.5e-08 34.2 10.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001302694.1_1 - 7.1e-09 35.2 10.0 1.7e-08 34.0 10.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001302694.1_1 - 2.1e-08 33.8 8.1 4.5e-08 32.7 8.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001302694.1_1 - 4.6e-08 32.8 9.0 9.5e-08 31.7 9.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_001302694.1_1 - 5.9e-08 32.7 9.7 1.4e-07 31.5 9.7 1.7 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.4 NM_001302694.1_1 - 6.9e-07 28.9 8.9 1.6e-06 27.7 8.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.4 NM_001302694.1_1 - 3.4e-05 23.8 11.5 6.9e-05 22.8 11.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.5 NM_001302694.1_1 - 0.0018 18.1 1.4 0.0043 17.0 1.4 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 NM_001302694.1_1 - 0.0044 16.6 1.7 0.0044 16.6 1.7 2.2 1 1 0 1 1 1 1 RING-like zinc finger DZR PF12773.5 NM_001302694.1_1 - 0.29 11.0 3.1 0.98 9.4 3.1 1.9 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_4 PF14570.4 NM_001302694.1_1 - 3.7 7.2 8.1 53 3.5 8.0 2.4 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Tmemb_cc2 PF10267.7 NM_001301036.1_2 - 3.4e-158 526.8 11.2 4.2e-158 526.5 11.2 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Rootletin PF15035.4 NM_001301036.1_2 - 0.042 13.8 0.2 0.042 13.8 0.2 2.3 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF2407_C PF13373.4 NM_001301036.1_2 - 0.1 12.6 0.1 0.1 12.6 0.1 1.6 2 0 0 2 2 2 0 DUF2407 C-terminal domain Acetyltransf_1 PF00583.23 NM_003491.3_2 - 3.3e-15 56.2 0.0 5.3e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 NM_003491.3_2 - 3.3e-10 39.9 0.1 5.5e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 NM_003491.3_2 - 3.3e-08 33.7 0.0 5.5e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 NM_003491.3_2 - 2e-07 30.7 0.0 3.9e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.5 NM_003491.3_2 - 0.0015 18.4 0.0 0.0032 17.4 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.3 NM_003491.3_2 - 0.0071 15.7 0.1 0.012 14.9 0.1 1.3 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_13 PF13880.4 NM_003491.3_2 - 0.0072 16.2 0.1 0.012 15.4 0.1 1.3 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_3 PF13302.5 NM_003491.3_2 - 0.014 15.9 0.0 0.03 14.9 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Voldacs PF03517.11 NM_001311202.1_3 - 2e-12 47.3 0.0 2.6e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling DUF3446 PF11928.6 NM_001136177.2_1 - 3.7e-24 84.7 6.5 3.7e-24 84.7 6.5 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF3446) zf-C2H2 PF00096.24 NM_001136177.2_1 - 3e-12 46.1 27.3 6.5e-06 26.2 0.1 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001136177.2_1 - 4.9e-12 45.6 9.0 8.3e-08 32.2 1.6 5.6 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001136177.2_1 - 0.00032 21.1 12.9 0.0052 17.4 2.1 5.1 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001136177.2_1 - 0.022 14.9 3.0 30 4.9 0.1 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.4 NM_001136177.2_1 - 0.024 14.4 10.5 0.4 10.5 0.5 3.9 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-BED PF02892.13 NM_001136177.2_1 - 0.88 9.5 16.5 0.038 13.9 4.4 3.0 2 1 1 3 3 3 0 BED zinc finger zf-C2H2_11 PF16622.3 NM_001136177.2_1 - 2.6 7.7 7.6 38 4.0 0.1 4.0 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 NM_001136177.2_1 - 4.5 7.2 11.9 5.3 7.0 0.3 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger zf-met PF12874.5 NM_001136177.2_1 - 8.3 6.8 8.2 5.5 7.4 1.3 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 NM_001079526.1_2 - 5.5e-12 45.4 26.6 5.4e-07 29.6 2.8 6.2 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001079526.1_2 - 1e-09 38.2 37.4 0.0005 20.2 1.3 6.4 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001079526.1_2 - 2.1e-06 28.0 35.3 0.0063 17.1 1.1 6.8 5 0 0 5 5 5 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_001079526.1_2 - 0.002 17.7 0.9 0.002 17.7 0.9 4.9 5 0 0 5 5 5 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 NM_001079526.1_2 - 2.5 8.0 27.2 0.33 10.8 5.6 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger T-box PF00907.20 NM_001303475.1_3 - 3.1e-70 236.0 1.0 5.6e-61 205.8 0.2 2.3 2 0 0 2 2 2 2 T-box Glyco_hydro_36C PF16874.3 NM_001303475.1_3 - 0.018 15.4 0.0 0.038 14.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 36 C-terminal domain OLF PF02191.14 NM_182487.3_3 - 6.9e-84 281.2 1.8 9.5e-84 280.7 1.8 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.6 NM_182487.3_3 - 0.00097 18.9 5.8 0.0013 18.6 0.3 2.3 1 1 1 2 2 2 1 Neurogenesis glycoprotein ANF_receptor PF01094.26 NM_001282470.2_2 - 4.8e-61 206.7 0.0 7e-61 206.1 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 NM_001282470.2_2 - 1.1e-47 161.5 1.2 1.3e-47 161.2 0.1 1.7 2 0 0 2 2 2 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_001282470.2_2 - 7.7e-44 148.4 0.0 1.8e-43 147.2 0.0 1.6 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_001282470.2_2 - 2.3e-19 69.6 0.0 3.7e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 RasGEF PF00617.17 NM_001035223.3_2 - 2.3e-53 180.8 0.0 3.5e-53 180.2 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 NM_001035223.3_2 - 1.3e-14 54.2 0.0 2.9e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 NM_001035223.3_2 - 4.4e-11 43.1 0.0 9.1e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain TerB_C PF15615.4 NM_001035223.3_2 - 1.9 8.7 5.2 32 4.7 3.0 2.6 2 0 0 2 2 2 0 TerB-C domain Myb_DNA-bind_5 PF13873.4 NM_001256141.1_1 - 3.6e-21 74.9 0.2 1.4e-20 73.0 0.1 2.0 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Metallophos PF00149.26 NM_001007593.2_3 - 1.5e-20 74.4 0.2 2.2e-20 73.9 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RasGEF PF00617.17 NM_001308251.1_1 - 1.9e-11 44.3 0.0 3.2e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain CALM_bind PF16025.3 NM_001323577.1_2 - 1e-27 96.2 13.6 5.2e-20 71.5 1.2 3.5 2 1 1 3 3 3 2 Calcium-dependent calmodulin binding Pacs-1 PF10254.7 NM_015197.3_1 - 6.2e-202 670.9 0.0 8.8e-202 670.4 0.0 1.2 1 0 0 1 1 1 1 PACS-1 cytosolic sorting protein 7tm_1 PF00001.19 NM_198718.1_1 - 4.2e-24 85.1 9.4 5.5e-24 84.7 9.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.7 NM_198718.1_1 - 0.00055 19.4 0.3 0.00055 19.4 0.3 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srx PF10328.7 NM_198718.1_1 - 0.00078 18.7 1.0 0.00078 18.7 1.0 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Piwi PF02171.15 NM_018068.3_2 - 5.6e-87 291.6 0.1 8.1e-87 291.1 0.1 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.20 NM_018068.3_2 - 2.3e-33 114.8 0.4 3.7e-33 114.1 0.4 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.8 NM_018068.3_2 - 6.6e-09 35.1 0.0 1.8e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.3 NM_018068.3_2 - 0.0051 17.4 0.0 0.01 16.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute 7tm_1 PF00001.19 NM_198923.2_1 - 5.8e-11 42.0 22.6 5.9e-10 38.7 22.6 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 60KD_IMP PF02096.18 NM_198923.2_1 - 7.5 6.3 8.7 3.4 7.4 1.5 2.2 1 1 1 2 2 2 0 60Kd inner membrane protein NDK PF00334.17 NM_001198682.1_1 - 9.8e-06 25.5 0.0 1.4e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase NDK PF00334.17 NM_001198682.1_3 - 8.3e-27 93.7 0.0 1e-26 93.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase RNase_PH PF01138.19 NM_001034194.1_1 - 7e-22 78.2 0.0 1.1e-21 77.6 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 NM_001034194.1_1 - 1.6e-12 47.1 0.0 4.3e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 EGF_2 PF07974.11 NM_005960.1_2 - 5.6 7.3 37.1 0.96 9.7 6.8 3.4 3 0 0 3 3 3 0 EGF-like domain DUF1459 PF07312.9 NM_030759.4_2 - 0.031 14.3 0.3 0.055 13.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1459) DUF1244 PF06844.9 NM_030759.4_2 - 0.078 13.0 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) NRBF2 PF08961.8 NM_030759.4_3 - 1.6e-101 337.8 5.1 2.4e-101 337.2 5.1 1.2 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator NRBF2_MIT PF17169.2 NM_030759.4_3 - 4.8e-51 170.8 9.2 9e-51 169.9 9.2 1.5 1 0 0 1 1 1 1 MIT domain of nuclear receptor-binding factor 2 MIT PF04212.16 NM_030759.4_3 - 0.0011 18.9 3.0 0.0021 18.0 3.0 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain bZIP_1 PF00170.19 NM_030759.4_3 - 0.005 16.8 1.7 0.005 16.8 1.7 2.1 3 0 0 3 3 3 1 bZIP transcription factor DUF972 PF06156.11 NM_030759.4_3 - 0.014 15.8 0.4 0.014 15.8 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DivIC PF04977.13 NM_030759.4_3 - 0.018 14.6 1.9 0.018 14.6 1.9 1.8 2 0 0 2 2 2 0 Septum formation initiator DUF5101 PF17031.3 NM_030759.4_3 - 0.072 13.1 0.7 0.18 11.8 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) HALZ PF02183.16 NM_030759.4_3 - 0.091 12.8 3.3 0.19 11.8 3.3 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper dsrm PF00035.24 NM_001164384.1_2 - 1.8e-37 127.7 3.0 1e-12 48.4 0.1 4.5 4 0 0 4 4 4 4 Double-stranded RNA binding motif Staufen_C PF16482.3 NM_001164384.1_2 - 2e-15 56.8 3.8 1.2e-14 54.2 0.2 3.5 4 0 0 4 4 4 1 Staufen C-terminal domain DND1_DSRM PF14709.5 NM_001164384.1_2 - 0.046 13.9 2.6 4.2 7.6 0.0 3.9 4 1 0 4 4 4 0 double strand RNA binding domain from DEAD END PROTEIN 1 Hexokinase_2 PF03727.14 NM_001322366.1_2 - 2.1e-175 580.5 0.1 5.3e-89 297.6 0.2 2.3 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.19 NM_001322366.1_2 - 1.2e-145 482.2 0.3 1.7e-74 249.9 0.0 2.2 2 0 0 2 2 2 2 Hexokinase CSD PF00313.20 NM_001322366.1_2 - 0.035 13.8 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain FGGY_N PF00370.19 NM_001322366.1_2 - 0.044 13.2 0.0 5.8 6.3 0.0 2.3 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain FAM70 PF14967.4 NM_017938.3_3 - 2.6e-156 520.1 3.2 4.2e-156 519.4 3.2 1.3 1 0 0 1 1 1 1 FAM70 protein DUF4064 PF13273.4 NM_017938.3_3 - 0.0049 17.1 10.2 0.087 13.1 6.2 3.1 2 1 0 2 2 2 2 Protein of unknown function (DUF4064) Phage_holin_3_2 PF04550.10 NM_017938.3_3 - 0.19 12.0 3.6 0.095 13.0 1.2 1.7 2 0 0 2 2 2 0 Phage holin family 2 Cyclin_N PF00134.21 NM_001142300.1_1 - 8.4e-16 57.8 0.7 1.3e-15 57.2 0.7 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.9 NM_001142300.1_1 - 2.6e-09 37.5 0.1 4e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Cyclin MHC_I PF00129.16 NM_018950.2_2 - 4.6e-89 296.6 0.6 6.5e-89 296.1 0.6 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_018950.2_2 - 7.5e-18 64.7 0.0 1.4e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 NM_018950.2_2 - 0.00038 19.8 0.0 0.00055 19.3 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 NM_018950.2_2 - 0.0023 17.8 0.1 0.0043 17.0 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 NM_018950.2_2 - 0.0025 17.8 0.0 0.0066 16.5 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin domain MHC_I_C PF06623.9 NM_018950.2_2 - 0.15 11.9 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 MHC_I C-terminus Homeobox PF00046.27 NM_003924.3_1 - 1.4e-22 79.1 2.8 2.9e-22 78.1 2.8 1.5 1 0 0 1 1 1 1 Homeobox domain Abhydrolase_1 PF00561.18 NM_032750.2_1 - 1.4e-09 37.8 0.0 0.00032 20.3 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_032750.2_1 - 4.5e-09 37.1 8.7 3.1e-06 27.9 3.0 2.9 2 1 1 3 3 3 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 NM_032750.2_1 - 8.2e-05 21.8 0.1 0.0044 16.2 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 zf-CW PF07496.13 NM_001324170.1_3 - 3.3e-14 52.6 5.8 5.7e-14 51.8 5.8 1.4 1 0 0 1 1 1 1 CW-type Zinc Finger PWWP PF00855.15 NM_001324170.1_3 - 1e-07 32.2 0.1 1.8e-07 31.4 0.1 1.3 1 0 0 1 1 1 1 PWWP domain EMP24_GP25L PF01105.22 NM_001303060.1_1 - 5.6e-20 71.9 0.0 1.1e-19 71.0 0.0 1.3 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD IL7 PF01415.14 NM_001199888.1_2 - 1.8e-23 83.0 8.5 1.4e-13 51.0 0.3 2.3 1 1 1 2 2 2 2 Interleukin 7/9 family Gasdermin PF04598.10 NM_004403.2_1 - 1.7e-164 548.1 1.1 2e-164 547.9 1.1 1.0 1 0 0 1 1 1 1 Gasdermin family RHD_dimer PF16179.3 NM_001258296.1_1 - 6.2e-25 87.1 0.4 9.9e-25 86.4 0.4 1.3 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.20 NM_001258296.1_1 - 6.4e-22 78.2 0.4 1.2e-21 77.2 0.4 1.5 1 1 0 1 1 1 1 Rel homology DNA-binding domain TIG PF01833.22 NM_001258296.1_1 - 2e-06 27.6 0.0 4.3e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 IPT/TIG domain Lipocalin PF00061.21 NM_001319041.1_3 - 8.4e-17 61.6 0.2 1.3e-16 61.0 0.2 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family zf-H2C2_2 PF13465.4 NM_001278713.1_3 - 2.4e-33 113.0 60.0 7e-08 32.4 3.8 9.9 12 0 0 12 12 12 7 Zinc-finger double domain KRAB PF01352.25 NM_001278713.1_3 - 1.2e-22 79.1 0.1 2.1e-22 78.3 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2 PF00096.24 NM_001278713.1_3 - 8.7e-08 32.1 64.3 1.9e-05 24.8 3.3 8.3 10 0 0 10 10 10 5 Zinc finger, C2H2 type GAGA PF09237.9 NM_001278713.1_3 - 0.0059 16.2 7.3 0.53 10.0 1.9 3.2 2 1 1 3 3 3 2 GAGA factor zf-C2H2_4 PF13894.4 NM_001278713.1_3 - 0.0078 16.8 2.2 0.0078 16.8 2.2 9.6 10 0 0 10 10 10 4 C2H2-type zinc finger zf-CCHC_2 PF13696.4 NM_001278713.1_3 - 2.2 8.0 24.9 4.4 7.1 0.4 5.6 5 0 0 5 5 5 0 Zinc knuckle Abi_HHR PF07815.12 NM_001012751.2_3 - 1.2e-35 121.3 0.5 2e-35 120.6 0.5 1.3 1 0 0 1 1 1 1 Abl-interactor HHR SH3_1 PF00018.26 NM_001012751.2_3 - 2.4e-16 58.9 0.4 7.9e-16 57.3 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 NM_001012751.2_3 - 1.8e-14 53.2 0.1 3.6e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001012751.2_3 - 1.6e-10 40.4 0.1 2.6e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain Metallophos PF00149.26 NM_001044370.1_2 - 1.9e-10 41.5 0.6 2.7e-10 41.0 0.6 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 NM_001044370.1_2 - 2.4e-06 27.7 0.0 3e-05 24.2 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain OAD_gamma PF04277.11 NM_001834.3_1 - 0.024 15.1 2.9 0.036 14.5 2.9 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Clathrin_lg_ch PF01086.15 NM_001834.3_2 - 7.9e-56 189.4 10.1 7.9e-56 189.4 10.1 1.9 2 0 0 2 2 2 1 Clathrin light chain WD40 PF00400.30 NM_006951.4_2 - 2.1e-56 186.5 11.3 1.7e-10 41.2 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.13 NM_006951.4_2 - 2.9e-50 169.8 5.7 4.7e-50 169.1 5.7 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.5 NM_006951.4_2 - 6.3e-14 51.9 0.0 0.00094 19.3 0.0 5.4 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_006951.4_2 - 3.9e-07 28.9 0.5 0.0039 15.8 0.0 3.3 4 0 0 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 NM_006951.4_2 - 6.1e-06 25.3 0.0 0.53 9.1 0.0 3.9 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein RAB3GAP2_N PF14655.4 NM_006951.4_2 - 0.0064 15.6 0.0 0.032 13.3 0.0 2.0 1 1 1 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Cytochrom_D1 PF02239.14 NM_006951.4_2 - 0.073 11.5 0.0 1 7.7 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain Late_protein_L2 PF00513.16 NM_006951.4_2 - 0.86 8.4 7.6 1.4 7.7 7.6 1.2 1 0 0 1 1 1 0 Late Protein L2 Tsg PF04668.10 NM_020648.5_3 - 2.4e-44 151.1 6.4 2.4e-44 151.1 6.4 2.4 2 0 0 2 2 2 1 Twisted gastrulation (Tsg) protein conserved region MAP7 PF05672.9 NM_001198614.1_1 - 8e-41 139.3 83.3 8e-41 139.3 83.3 2.9 2 1 1 3 3 3 1 MAP7 (E-MAP-115) family PH_5 PF15405.4 NM_001198614.1_1 - 0.0058 16.6 0.2 0.018 15.0 0.2 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain DUF106 PF01956.14 NM_019026.4_1 - 3.5e-42 143.9 0.7 7.9e-42 142.7 0.7 1.6 1 0 0 1 1 1 1 Integral membrane protein DUF106 Vpu PF00558.17 NM_019026.4_1 - 0.74 9.5 4.5 0.18 11.5 0.4 2.0 2 0 0 2 2 2 0 Vpu protein Atrophin-1 PF03154.13 NM_019026.4_2 - 1.2 7.2 4.5 1.6 6.8 4.5 1.0 1 0 0 1 1 1 0 Atrophin-1 family Y_phosphatase PF00102.25 NM_012411.5_2 - 1.6e-68 230.6 0.7 2.8e-68 229.8 0.7 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 NM_012411.5_2 - 0.0014 18.5 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 NM_012411.5_2 - 0.022 14.5 0.4 0.083 12.6 0.0 2.2 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Tiny_TM_bacill PF09680.8 NM_012411.5_3 - 0.18 11.4 3.2 0.49 10.0 3.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (Tiny_TM_bacill) Filament PF00038.19 NM_005557.3_2 - 3.1e-118 394.8 28.8 3.6e-118 394.6 28.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 NM_005557.3_2 - 0.01 15.8 1.0 0.01 15.8 1.0 4.0 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein Glyco_hyd_65N_2 PF14498.4 NM_005557.3_2 - 0.092 12.5 0.2 0.26 11.0 0.2 1.7 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain KIF1B PF12423.6 NM_005557.3_2 - 0.15 12.5 0.2 0.54 10.7 0.2 2.0 1 0 0 1 1 1 0 Kinesin protein 1B zf-C4H2 PF10146.7 NM_005557.3_2 - 0.55 10.4 16.0 1.5 8.9 6.5 2.9 2 1 1 3 3 3 0 Zinc finger-containing protein DUF4407 PF14362.4 NM_005557.3_2 - 2.9 7.0 15.4 6.2 6.0 6.4 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) Cep57_MT_bd PF06657.11 NM_005557.3_2 - 3.8 7.9 17.3 11 6.4 0.8 4.6 3 1 1 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Reo_sigmaC PF04582.10 NM_005557.3_2 - 7.2 5.8 9.6 6.3 6.0 3.9 3.0 3 1 1 4 4 4 0 Reovirus sigma C capsid protein MtrE PF04206.10 NM_005557.3_3 - 0.2 10.8 5.1 0.28 10.3 5.1 1.1 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E FixS PF03597.13 NM_005557.3_3 - 0.65 9.6 7.0 0.7 9.5 5.8 1.7 1 1 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type DEAD PF00270.27 NM_201224.1_2 - 6.5e-48 162.7 0.1 9.5e-48 162.1 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_201224.1_2 - 2.3e-20 72.9 0.2 1.1e-19 70.7 0.1 2.2 1 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_201224.1_2 - 7.4e-06 25.9 0.0 1.3e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit EF-hand_6 PF13405.4 NM_001195518.1_1 - 7.4e-12 44.1 4.0 5.1e-05 22.8 0.2 4.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.30 NM_001195518.1_1 - 1.3e-11 43.1 7.6 3.1e-05 23.1 0.1 3.9 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.4 NM_001195518.1_1 - 1.9e-08 33.3 4.1 4.6e-06 25.8 1.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 NM_001195518.1_1 - 5.3e-08 33.1 5.9 0.00077 19.8 0.7 3.4 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 NM_001195518.1_1 - 2.4e-07 30.3 7.2 5.8e-05 22.6 0.1 3.3 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.5 NM_001195518.1_1 - 0.00033 20.4 0.3 0.036 13.9 0.1 2.4 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand C2 PF00168.28 NM_001286173.1_2 - 1.2e-22 80.0 0.2 4.1e-22 78.3 0.0 1.9 2 0 0 2 2 2 1 C2 domain YbjQ_1 PF01906.15 NM_001286173.1_2 - 0.00064 20.2 5.8 0.041 14.4 0.0 4.6 4 1 0 4 4 4 1 Putative heavy-metal-binding Calcyon PF06387.9 NM_001040101.1_1 - 3e-83 278.1 0.1 4.5e-83 277.6 0.1 1.2 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) zf-H2C2_2 PF13465.4 NM_001320668.1_1 - 1.8e-84 274.5 109.8 2.1e-08 34.1 0.4 14.9 15 0 0 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001320668.1_1 - 4.4e-53 174.8 106.5 9.3e-05 22.6 3.6 14.5 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001320668.1_1 - 6.2e-24 82.5 102.1 0.028 15.1 0.9 14.6 14 0 0 14 14 14 13 C2H2-type zinc finger KRAB PF01352.25 NM_001320668.1_1 - 6.9e-23 79.9 1.6 1.4e-22 78.9 1.6 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001320668.1_1 - 3.7e-15 55.3 90.7 0.025 14.4 0.9 14.2 15 0 0 15 15 15 12 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001320668.1_1 - 1.4e-10 41.0 81.1 0.0041 17.1 3.7 9.6 2 1 6 10 10 10 8 Zinc ribbon domain C1_4 PF07975.10 NM_001320668.1_1 - 0.00023 21.2 62.9 0.54 10.4 7.1 9.6 3 2 8 11 11 11 3 TFIIH C1-like domain DUF3268 PF11672.6 NM_001320668.1_1 - 0.53 10.5 44.0 2.8 8.2 2.2 7.1 5 1 3 8 8 8 0 zinc-finger-containing domain XPA_N PF01286.16 NM_001320668.1_1 - 1.5 8.8 75.9 12 5.9 0.1 14.2 14 0 0 14 14 14 0 XPA protein N-terminal Baculo_LEF-11 PF06385.10 NM_001320668.1_2 - 0.11 12.9 12.7 20 5.6 0.0 5.3 4 1 0 5 5 5 0 Baculovirus LEF-11 protein Lipoxygenase PF00305.17 NM_001140.3_3 - 8.8e-58 196.1 0.0 1.9e-56 191.7 0.0 2.6 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.21 NM_001140.3_3 - 4.1e-19 69.2 0.0 7.2e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain IL17_R_N PF15037.4 NM_001203265.1_3 - 1.8e-141 471.6 10.4 5.4e-139 463.5 10.4 2.9 1 1 0 1 1 1 1 Interleukin-17 receptor extracellular region SEFIR PF08357.9 NM_001203265.1_3 - 1e-38 132.8 0.0 1.6e-38 132.2 0.0 1.3 1 0 0 1 1 1 1 SEFIR domain IQ PF00612.25 NM_001270450.1_3 - 3.2e-05 23.2 0.4 9.3e-05 21.8 0.4 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif Pkinase PF00069.23 NM_001166169.1_3 - 1.4e-65 221.2 0.0 1.8e-65 220.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001166169.1_3 - 2.7e-46 157.8 0.0 3.7e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001166169.1_3 - 6.4e-05 22.3 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001166169.1_3 - 0.011 14.9 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SPARC_Ca_bdg PF10591.7 NM_001309444.1_3 - 2.8e-39 133.8 0.2 6.2e-39 132.7 0.2 1.6 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_1 PF00050.19 NM_001309444.1_3 - 7.7e-13 48.1 4.4 7.7e-13 48.1 4.4 3.2 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 NM_001309444.1_3 - 1.1e-10 41.3 2.2 3e-10 40.0 2.2 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain FOLN PF09289.8 NM_001309444.1_3 - 1.5e-09 37.7 8.3 4.1e-09 36.3 8.3 1.8 1 0 0 1 1 1 1 Follistatin/Osteonectin-like EGF domain STOP PF05217.10 NM_001287050.1_3 - 0.0012 18.9 7.0 0.0012 18.9 7.0 2.5 2 0 0 2 2 2 1 STOP protein Cadherin_3 PF16184.3 NM_001166133.1_3 - 1e-105 347.3 8.4 1.8e-20 72.9 0.1 7.8 7 2 0 7 7 7 7 Cadherin-like VWC PF00093.16 NM_001166133.1_3 - 5.8e-31 106.5 134.4 6.7e-10 39.0 15.4 18.6 13 4 5 18 18 18 6 von Willebrand factor type C domain GF_recep_IV PF14843.4 NM_001166133.1_3 - 5.2e-07 29.4 106.4 1.6e-05 24.5 37.3 11.9 1 1 10 13 13 13 7 Growth factor receptor domain IV Furin-like_2 PF15913.3 NM_001166133.1_3 - 2.2e-06 27.7 36.8 3.5e-06 27.0 13.8 13.4 3 1 10 13 13 13 8 Furin-like repeat, cysteine-rich Furin-like PF00757.18 NM_001166133.1_3 - 1.6e-05 24.7 29.8 1.6e-05 24.7 29.8 11.7 1 1 9 11 11 11 4 Furin-like cysteine rich region VSP PF03302.11 NM_001166133.1_3 - 0.00062 18.6 13.0 0.00062 18.6 13.0 12.0 2 2 9 11 11 11 9 Giardia variant-specific surface protein RCDG1 PF15725.3 NM_022895.2_3 - 0.43 10.9 3.7 1.7 9.0 3.7 1.9 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein Filament PF00038.19 NM_001146225.1_3 - 9.2e-104 347.2 30.7 1.1e-103 347.0 30.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 NM_001146225.1_3 - 3.2e-16 59.8 32.0 1.1e-15 58.1 3.2 3.2 2 1 1 3 3 3 2 Keratin type II head CENP-F_leu_zip PF10473.7 NM_001146225.1_3 - 6.8e-07 29.3 24.3 8.1e-05 22.5 4.9 3.4 2 2 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.4 NM_001146225.1_3 - 0.003 16.2 10.9 0.003 16.2 10.9 1.6 1 1 0 1 1 1 1 AAA domain Reo_sigmaC PF04582.10 NM_001146225.1_3 - 0.0081 15.5 3.6 0.22 10.8 0.2 2.5 1 1 0 2 2 2 1 Reovirus sigma C capsid protein Spc7 PF08317.9 NM_001146225.1_3 - 0.018 13.8 30.0 0.011 14.5 5.3 3.5 1 1 3 4 4 4 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 NM_001146225.1_3 - 0.023 14.6 0.2 0.023 14.6 0.2 4.1 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein ADIP PF11559.6 NM_001146225.1_3 - 0.08 12.9 17.8 0.037 14.0 3.4 3.5 2 2 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF713 PF05218.12 NM_001146225.1_3 - 0.13 11.8 0.1 0.13 11.8 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF713) DUF5082 PF16888.3 NM_001146225.1_3 - 0.17 12.1 21.5 0.096 12.9 0.6 4.6 1 1 2 4 4 4 0 Domain of unknown function (DUF5082) ATG16 PF08614.9 NM_001146225.1_3 - 0.18 11.8 25.2 0.1 12.6 8.9 3.5 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) IncA PF04156.12 NM_001146225.1_3 - 0.19 11.4 28.3 0.55 9.9 13.0 3.4 1 1 1 2 2 2 0 IncA protein Alanine_zipper PF11839.6 NM_001146225.1_3 - 0.4 10.9 5.8 0.093 12.9 1.6 2.1 2 1 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein Baculo_PEP_C PF04513.10 NM_001146225.1_3 - 0.6 10.0 14.6 0.23 11.3 1.6 4.0 1 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.10 NM_001146225.1_3 - 0.64 9.9 17.0 0.065 13.1 1.5 4.0 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) DUF342 PF03961.11 NM_001146225.1_3 - 1 7.7 17.1 1.1 7.6 3.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Syntaxin-6_N PF09177.9 NM_001146225.1_3 - 2.4 8.6 8.8 0.49 10.8 1.2 3.3 1 1 1 3 3 3 0 Syntaxin 6, N-terminal KfrA_N PF11740.6 NM_001146225.1_3 - 3.7 8.1 11.7 0.072 13.6 2.5 2.7 2 1 1 3 3 3 0 Plasmid replication region DNA-binding N-term CLZ PF16526.3 NM_001146225.1_3 - 4.9 7.5 12.0 1.3 9.3 1.5 4.1 3 2 2 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Lebercilin PF15619.4 NM_001146225.1_3 - 5.2 6.5 25.4 3.6 7.1 7.7 2.5 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4988 PF16378.3 NM_001146225.1_3 - 7.7 5.9 7.4 8.8 5.7 0.6 3.2 3 1 2 5 5 5 0 Domain of unknown function V_ATPase_I PF01496.17 NM_001146225.1_3 - 9 3.9 13.5 0.27 9.0 0.7 2.4 2 1 0 2 2 2 0 V-type ATPase 116kDa subunit family CK1gamma_C PF12605.6 NM_004384.4_2 - 3.1e-32 111.5 7.4 4.8e-32 110.9 7.4 1.3 1 0 0 1 1 1 1 Casein kinase 1 gamma C terminal Pkinase PF00069.23 NM_004384.4_2 - 8.4e-26 90.8 0.0 1.2e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_004384.4_2 - 7.3e-14 51.5 0.0 1.1e-13 51.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase BRICHOS PF04089.12 NM_001012514.2_3 - 8.7e-21 73.7 0.0 1.3e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain 7tm_4 PF13853.4 NM_001001957.2_1 - 2.6e-46 158.5 11.2 3.2e-46 158.2 11.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001001957.2_1 - 1.5e-22 80.0 11.2 2.6e-22 79.2 11.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001001957.2_1 - 0.0082 15.4 4.9 0.0082 15.4 4.9 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx PFK PF00365.18 NM_002626.5_1 - 3e-203 672.9 7.9 2.1e-107 358.5 2.6 2.1 2 0 0 2 2 2 2 Phosphofructokinase zf-RING_2 PF13639.4 NM_014868.4_1 - 5.8e-07 29.5 9.9 1.5e-06 28.2 9.9 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 NM_014868.4_1 - 1e-06 28.4 8.9 2.5e-06 27.1 8.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_014868.4_1 - 4.5e-06 26.3 6.5 9e-06 25.3 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_014868.4_1 - 8e-06 25.6 6.8 1.8e-05 24.4 6.8 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_014868.4_1 - 1.1e-05 25.2 9.5 1.2e-05 25.1 6.0 2.8 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_014868.4_1 - 3.7e-05 23.3 9.0 9e-05 22.1 9.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_014868.4_1 - 0.00053 19.7 7.0 0.0014 18.3 6.9 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 NM_014868.4_1 - 0.045 13.7 5.5 0.085 12.8 5.5 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger GCS2 PF04107.11 NM_014868.4_1 - 0.077 12.2 0.1 0.13 11.4 0.1 1.3 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) zf-RING_6 PF14835.4 NM_014868.4_1 - 0.1 12.4 4.4 0.32 10.8 4.4 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.4 NM_014868.4_1 - 0.22 11.5 14.6 0.027 14.5 9.4 2.4 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.5 NM_014868.4_1 - 0.35 11.1 10.3 0.72 10.1 10.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain OAD_gamma PF04277.11 NM_001142565.1_2 - 2.5 8.6 4.1 4.4 7.8 4.1 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain RRM_1 PF00076.20 NM_001142565.1_3 - 1e-05 25.1 0.0 1.9e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OAD_gamma PF04277.11 NM_001142565.1_3 - 1.6 9.2 3.1 4.5 7.8 3.1 1.8 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain RA PF00788.21 NM_001291964.1_2 - 5.2e-46 155.1 0.0 6.9e-23 81.0 0.0 2.8 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain DIL PF01843.17 NM_001291964.1_2 - 7.8e-31 106.3 2.1 1.2e-30 105.8 0.6 2.1 2 0 0 2 2 2 1 DIL domain PDZ PF00595.22 NM_001291964.1_2 - 1.8e-16 60.1 0.5 1.8e-16 60.1 0.5 1.9 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) FHA PF00498.24 NM_001291964.1_2 - 6.1e-07 29.6 0.0 1.3e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 FHA domain PDZ_2 PF13180.4 NM_001291964.1_2 - 0.002 18.3 0.4 0.0056 16.8 0.4 1.7 1 0 0 1 1 1 1 PDZ domain Yop-YscD_cpl PF16697.3 NM_001291964.1_2 - 0.0075 16.4 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain MHC_I PF00129.16 NM_005514.7_1 - 3.3e-96 319.8 1.6 4.6e-96 319.4 1.6 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_005514.7_1 - 6.9e-17 61.6 0.6 1.2e-16 60.8 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 NM_005514.7_1 - 8.9e-15 54.2 10.4 1.9e-14 53.2 10.4 1.6 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 NM_005514.7_1 - 0.0015 18.5 0.1 0.0036 17.2 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 NM_005514.7_1 - 0.0036 17.3 0.1 0.0067 16.4 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain RBD PF02196.13 NM_006480.4_3 - 1.1e-30 105.3 0.2 9.8e-22 76.7 0.0 2.4 2 0 0 2 2 2 2 Raf-like Ras-binding domain RGS PF00615.17 NM_006480.4_3 - 1.1e-27 96.5 1.4 1.6e-27 96.0 1.4 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain GoLoco PF02188.15 NM_006480.4_3 - 5.3e-06 25.7 0.0 1.1e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 GoLoco motif RGS12_us1 PF16613.3 NM_006480.4_3 - 0.0052 17.0 0.1 0.02 15.1 0.1 2.0 1 0 0 1 1 1 1 Unstructured region of RGS12 Homeobox PF00046.27 NM_001099685.1_2 - 3.5e-16 58.6 3.2 6e-16 57.9 3.2 1.4 1 0 0 1 1 1 1 Homeobox domain TNFR_c6 PF00020.16 NM_001270951.1_1 - 9.1e-12 45.1 38.3 0.00046 20.4 0.5 4.7 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region ALS2CR8 PF15299.4 NM_001104586.2_3 - 3.1e-61 206.9 0.8 4.8e-61 206.3 0.8 1.2 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Hormone_5 PF00184.15 NM_000915.3_1 - 7e-32 110.0 25.0 7e-32 110.0 25.0 1.6 2 0 0 2 2 2 1 Neurohypophysial hormones, C-terminal Domain Hormone_4 PF00220.15 NM_000915.3_1 - 0.00037 20.0 3.9 0.0012 18.4 3.9 2.0 1 0 0 1 1 1 1 Neurohypophysial hormones, N-terminal Domain Y_phosphatase PF00102.25 NM_001131008.1_1 - 2.5e-80 269.3 0.3 3.5e-80 268.8 0.3 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 NM_001131008.1_1 - 0.00041 20.2 0.0 0.0007 19.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 NM_001131008.1_1 - 0.019 14.7 0.0 0.045 13.4 0.0 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 NM_001131008.1_1 - 0.06 13.4 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 0 Inositol hexakisphosphate Pkinase PF00069.23 NM_001270486.1_3 - 1.3e-63 214.8 0.0 3.6e-63 213.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001270486.1_3 - 2.8e-32 111.9 0.0 8.6e-31 107.0 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001270486.1_3 - 4.8e-07 29.2 0.0 6.9e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF2045 PF09741.7 NM_001009880.1_1 - 1.2e-99 332.4 0.5 1.8e-99 331.8 0.5 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) Myelin_MBP PF01669.15 NM_001025090.1_2 - 9.4e-70 234.0 8.4 1.8e-69 233.1 8.4 1.5 1 0 0 1 1 1 1 Myelin basic protein LIDHydrolase PF10230.7 NM_001282724.1_1 - 1.3e-15 57.5 0.0 2.1e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase LIDHydrolase PF10230.7 NM_001282724.1_3 - 1.7e-17 63.8 0.0 2.6e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase zf-H2C2_2 PF13465.4 NM_001318473.1_1 - 5e-62 203.6 54.3 4.5e-10 39.4 1.0 10.5 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001318473.1_1 - 1.1e-50 167.1 51.0 8.5e-07 29.0 0.3 9.3 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001318473.1_1 - 6.4e-25 85.6 56.2 0.0027 18.3 0.2 9.4 9 0 0 9 9 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001318473.1_1 - 1.7e-20 72.3 38.7 0.0013 18.4 0.2 9.0 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001318473.1_1 - 4.6e-11 42.6 32.7 0.93 9.8 0.0 8.7 8 0 0 8 8 8 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001318473.1_1 - 1.3e-05 25.1 39.1 0.014 15.4 2.2 5.7 4 2 3 7 7 7 4 Zinc ribbon domain zf-met PF12874.5 NM_001318473.1_1 - 0.00016 21.8 50.0 0.0097 16.1 2.0 8.9 9 0 0 9 9 9 4 Zinc-finger of C2H2 type zf-Di19 PF05605.10 NM_001318473.1_1 - 0.014 15.5 2.5 0.014 15.5 2.5 4.4 2 1 2 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Zn_Tnp_IS1595 PF12760.5 NM_001318473.1_1 - 0.03 14.2 36.3 0.22 11.4 2.6 6.9 6 1 1 7 7 7 0 Transposase zinc-ribbon domain DUF3268 PF11672.6 NM_001318473.1_1 - 0.036 14.3 17.5 0.53 10.5 0.2 4.4 3 1 0 4 4 4 0 zinc-finger-containing domain CpXC PF14353.4 NM_001318473.1_1 - 0.089 12.7 23.8 1.6 8.6 1.2 7.0 2 2 5 7 7 7 0 CpXC protein C1_4 PF07975.10 NM_001318473.1_1 - 0.25 11.5 35.1 0.37 11.0 2.9 6.2 2 1 5 8 8 7 0 TFIIH C1-like domain XPA_N PF01286.16 NM_001318473.1_1 - 0.57 10.1 32.5 7.8 6.5 0.3 8.0 8 0 0 8 8 8 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001318473.1_1 - 0.74 10.5 33.7 1 10.0 2.0 5.2 2 1 4 6 6 6 0 zinc-ribbon family zf-C2HE PF16278.3 NM_001318473.1_1 - 1.2 9.5 42.6 6 7.3 0.2 8.4 2 2 4 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-AN1 PF01428.14 NM_001318473.1_1 - 3.5 7.7 34.8 35 4.5 0.1 8.7 7 1 1 8 8 8 0 AN1-like Zinc finger FYDLN_acid PF09538.8 NM_001318473.1_1 - 8.1 7.0 15.0 38 4.9 0.1 5.7 3 3 2 5 5 5 0 Protein of unknown function (FYDLN_acid) A2M_comp PF07678.12 NM_001735.2_1 - 6.2e-65 219.0 0.2 9.3e-65 218.4 0.2 1.3 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_N_2 PF07703.12 NM_001735.2_1 - 7.9e-28 97.4 0.2 2e-26 92.9 0.0 3.0 2 1 0 3 3 3 1 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 NM_001735.2_1 - 4.2e-27 93.7 0.1 1.5e-26 91.9 0.1 2.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin family NTR PF01759.19 NM_001735.2_1 - 2.3e-24 85.1 0.2 5.3e-24 84.0 0.2 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module A2M_recep PF07677.12 NM_001735.2_1 - 1.2e-23 83.6 0.0 3.8e-22 78.7 0.0 2.9 2 0 0 2 2 2 1 A-macroglobulin receptor A2M_N PF01835.17 NM_001735.2_1 - 2.9e-15 56.3 0.0 3.5e-13 49.7 0.0 3.0 3 0 0 3 3 3 1 MG2 domain ANATO PF01821.16 NM_001735.2_1 - 1.9e-08 34.9 11.2 5.4e-08 33.4 11.2 1.9 1 0 0 1 1 1 1 Anaphylotoxin-like domain DUF4369 PF14289.4 NM_001735.2_1 - 0.00056 20.4 0.1 0.0081 16.6 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4369) Metallophos PF00149.26 NM_001303503.1_3 - 1.5e-39 136.5 0.1 2.2e-39 135.9 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 NM_001303503.1_3 - 0.0017 18.6 1.5 0.0022 18.2 0.6 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Clat_adaptor_s PF01217.18 NM_001301081.1_1 - 2.1e-61 205.9 7.6 2.5e-61 205.6 7.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain NUDIX PF00293.26 NM_001248011.1_1 - 4.5e-08 33.1 0.1 1.2e-07 31.7 0.1 1.7 1 1 0 1 1 1 1 NUDIX domain DUF1725 PF08333.9 NM_001248011.1_1 - 1.5 8.5 5.9 0.095 12.3 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1725) LRRNT PF01462.16 NM_133506.3_2 - 6.2e-10 38.4 5.6 1.6e-09 37.0 5.6 1.8 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_8 PF13855.4 NM_133506.3_2 - 1.3e-07 31.2 0.2 2.3e-07 30.3 0.2 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.5 NM_133506.3_2 - 2.8e-05 24.2 2.4 7e-05 23.0 2.4 1.7 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) His_Phos_2 PF00328.20 NM_001302489.1_1 - 8.7e-33 114.1 0.3 3.1e-31 108.9 0.3 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Cystatin PF00031.19 NM_001900.4_2 - 2.6e-29 101.2 0.2 5.3e-29 100.2 0.2 1.5 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 NM_001900.4_2 - 0.00064 19.9 0.1 0.001 19.2 0.1 1.3 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor TFIIE_alpha PF02002.15 NM_005513.2_1 - 1.9e-37 127.2 1.5 3.3e-37 126.4 1.5 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit TFIIE-A_C PF11521.6 NM_005513.2_1 - 9.4e-32 109.1 6.6 1.9e-31 108.1 6.6 1.5 1 0 0 1 1 1 1 C-terminal general transcription factor TFIIE alpha TF_Zn_Ribbon PF08271.10 NM_005513.2_1 - 5.2e-13 48.2 0.7 5.2e-13 48.2 0.7 1.8 2 0 0 2 2 2 1 TFIIB zinc-binding S-AdoMet_synt_C PF02773.14 NM_005911.5_2 - 1.5e-67 225.7 0.0 2.3e-67 225.1 0.0 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.14 NM_005911.5_2 - 2.2e-45 153.6 0.0 3.8e-45 152.8 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.18 NM_005911.5_2 - 1.4e-43 147.4 0.2 2.3e-43 146.7 0.2 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.17 NM_005911.5_2 - 0.072 11.7 0.4 0.24 10.0 0.2 1.7 1 1 1 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) LRR_8 PF13855.4 NM_001393.3_2 - 4.6e-45 151.1 26.6 1.2e-15 56.9 1.1 6.8 5 2 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 NM_001393.3_2 - 1e-23 82.7 34.2 1.2e-05 25.3 0.9 8.7 5 1 3 9 9 9 9 Leucine Rich repeats (2 copies) VWC PF00093.16 NM_001393.3_2 - 8.6e-11 41.9 14.6 1.4e-10 41.2 14.6 1.4 1 0 0 1 1 1 1 von Willebrand factor type C domain LRR_5 PF13306.4 NM_001393.3_2 - 1.1e-08 35.0 6.2 9.2e-05 22.3 0.1 3.6 2 1 0 3 3 3 2 Leucine rich repeats (6 copies) Amnionless PF14828.4 NM_001393.3_2 - 3.2e-06 26.1 2.5 5.5e-06 25.4 2.5 1.3 1 0 0 1 1 1 1 Amnionless LRR_1 PF00560.31 NM_001393.3_2 - 9.3e-06 25.3 33.2 1.9 9.2 0.1 11.3 9 2 0 9 9 9 3 Leucine Rich Repeat FNIP PF05725.10 NM_001393.3_2 - 2.7e-05 24.1 5.3 11 6.2 0.2 5.9 4 1 2 6 6 6 2 FNIP Repeat LRR_9 PF14580.4 NM_001393.3_2 - 0.0016 17.8 19.4 2 7.7 1.2 4.7 1 1 3 5 5 5 3 Leucine-rich repeat Spore_coat_CotO PF14153.4 NM_001393.3_2 - 1.1 9.0 10.8 2.6 7.8 10.8 1.5 1 0 0 1 1 1 0 Spore coat protein CotO BUD22 PF09073.8 NM_001393.3_2 - 1.4 8.0 14.8 2.1 7.4 14.8 1.1 1 0 0 1 1 1 0 BUD22 LRR_6 PF13516.4 NM_001393.3_2 - 1.6 8.9 0.0 0.14 12.2 0.2 9.4 12 0 0 12 12 12 0 Leucine Rich repeat DUF4679 PF15728.3 NM_178553.3_2 - 5.5e-217 720.3 47.3 7e-217 720.0 47.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4679) Homeobox PF00046.27 NM_001485.3_3 - 1.8e-23 81.9 6.0 3e-23 81.2 6.0 1.4 1 0 0 1 1 1 1 Homeobox domain CEP170_C PF15308.4 NM_001485.3_3 - 0.59 8.5 6.7 0.46 8.8 4.6 1.6 1 1 1 2 2 2 0 CEP170 C-terminus Lipocalin PF00061.21 NM_001323518.1_2 - 4.6e-22 78.6 0.0 6.2e-22 78.2 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 NM_001323518.1_2 - 5.8e-06 26.2 0.0 9.8e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.11 NM_001323518.1_2 - 0.04 13.7 0.5 0.2 11.4 0.5 1.9 1 1 0 1 1 1 0 Triabin Galactosyl_T PF01762.19 NM_001038628.1_2 - 4e-63 212.6 0.1 5.5e-63 212.2 0.1 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 NM_001038628.1_2 - 0.00055 19.3 0.0 0.00087 18.7 0.0 1.2 1 0 0 1 1 1 1 Fringe-like Cystatin PF00031.19 NM_001322.2_1 - 3e-29 101.0 0.0 3.8e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 NM_001322.2_1 - 1.3e-05 25.3 0.0 2.1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor zf-C2H2 PF00096.24 NM_001324246.1_1 - 0.0026 18.0 2.9 0.0026 18.0 2.9 4.1 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_001324246.1_1 - 0.017 15.0 5.6 0.55 10.1 1.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger PHD PF00628.27 NM_001324246.1_1 - 0.017 14.9 2.3 0.084 12.6 2.3 2.3 1 0 0 1 1 1 0 PHD-finger HNH PF01844.21 NM_001324246.1_1 - 0.15 12.2 5.0 0.51 10.4 5.0 2.0 1 0 0 1 1 1 0 HNH endonuclease zf-C2H2_4 PF13894.4 NM_001324246.1_1 - 0.32 11.8 10.5 0.14 12.9 1.6 3.9 2 0 0 2 2 2 0 C2H2-type zinc finger GETHR PF05671.9 NM_001324246.1_1 - 7.4 5.9 12.4 46 3.4 0.1 5.5 6 0 0 6 6 6 0 GETHR pentapeptide repeat (5 copies) zf-H2C2_2 PF13465.4 NM_001324246.1_2 - 2.5e-65 214.0 91.1 4.9e-08 32.9 0.2 13.5 14 0 0 14 14 14 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001324246.1_2 - 8.8e-47 154.9 98.5 3.9e-06 26.9 1.3 13.3 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001324246.1_2 - 8e-26 88.4 82.3 0.00089 19.8 1.0 12.7 11 0 0 11 11 11 10 C2H2-type zinc finger KRAB PF01352.25 NM_001324246.1_2 - 4.7e-25 86.8 0.1 8.9e-25 86.0 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001324246.1_2 - 1.9e-10 40.3 70.4 0.016 15.0 0.8 11.4 11 0 0 11 11 11 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001324246.1_2 - 5.2e-07 29.6 45.9 0.023 14.7 2.1 7.1 6 0 0 6 6 6 5 Zinc ribbon domain C1_4 PF07975.10 NM_001324246.1_2 - 0.0046 17.1 45.9 0.61 10.3 2.9 6.8 3 3 2 5 5 5 3 TFIIH C1-like domain zf-C2H2_jaz PF12171.6 NM_001324246.1_2 - 0.032 14.4 56.1 0.29 11.4 0.4 10.3 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001324246.1_2 - 0.4 11.3 39.1 1.2 9.8 0.5 5.9 1 1 4 6 6 6 0 zinc-ribbon family PH PF00169.27 NM_001267068.1_3 - 1.2e-07 32.1 0.1 2e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_001267068.1_3 - 0.071 13.4 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain PDDEXK_10 PF07788.9 NM_021047.2_1 - 0.0023 17.7 0.3 45 3.9 0.0 6.1 8 1 0 8 8 8 2 PD-(D/E)XK nuclease superfamily zf-H2C2_2 PF13465.4 NM_021047.2_2 - 6.1e-07 29.5 0.6 6.1e-07 29.5 0.6 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.24 NM_021047.2_2 - 0.025 14.9 3.7 0.03 14.6 0.2 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_021047.2_2 - 0.47 10.3 4.5 0.26 11.2 0.2 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_021047.2_3 - 2.1e-89 290.1 122.2 3.9e-09 36.4 1.5 15.6 15 0 0 15 15 15 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_021047.2_3 - 5e-55 180.9 102.1 3.8e-06 26.9 0.9 13.7 14 0 0 14 14 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_021047.2_3 - 1.8e-30 102.8 87.2 0.0068 17.0 0.8 13.1 12 0 0 12 12 12 11 C2H2-type zinc finger KRAB PF01352.25 NM_021047.2_3 - 1.2e-23 82.4 0.4 3e-23 81.1 0.1 1.9 2 0 0 2 2 2 1 KRAB box zf-C2H2_6 PF13912.4 NM_021047.2_3 - 3.6e-21 74.5 90.7 0.0013 18.5 0.1 14.1 14 1 0 14 14 13 11 C2H2-type zinc finger XPA_N PF01286.16 NM_021047.2_3 - 1.5e-15 56.8 56.5 0.49 10.3 0.1 12.8 13 0 0 13 13 13 9 XPA protein N-terminal zf-C2H2_jaz PF12171.6 NM_021047.2_3 - 6.3e-13 48.5 69.2 0.013 15.7 0.1 13.9 15 0 0 15 15 13 7 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_021047.2_3 - 3.6e-11 42.9 74.4 0.12 12.4 6.6 10.8 3 2 10 13 13 13 12 Zinc ribbon domain C1_4 PF07975.10 NM_021047.2_3 - 1.6e-08 34.5 51.1 0.11 12.7 1.7 9.4 2 1 5 9 9 9 6 TFIIH C1-like domain SprT-like PF10263.7 NM_021047.2_3 - 1.5e-07 31.3 61.1 0.13 11.9 4.9 6.9 2 1 3 6 6 6 5 SprT-like family zf-C2H2_11 PF16622.3 NM_021047.2_3 - 4.3e-07 29.4 37.7 0.51 10.0 0.1 12.2 13 0 0 13 13 13 3 zinc-finger C2H2-type zf-RING_7 PF02591.13 NM_021047.2_3 - 0.00019 21.4 39.0 8.7 6.5 0.1 11.3 11 0 0 11 11 11 1 C4-type zinc ribbon domain zf-trcl PF13451.4 NM_021047.2_3 - 0.00046 19.9 55.8 1.3 8.8 0.1 11.1 10 2 1 11 11 10 2 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 NM_021047.2_3 - 0.071 13.7 58.9 1 10.0 0.9 7.5 3 1 7 10 10 9 0 zinc-ribbon family DUF3268 PF11672.6 NM_021047.2_3 - 0.65 10.2 44.2 0.93 9.7 2.3 6.8 2 1 5 9 9 9 0 zinc-finger-containing domain ADK_lid PF05191.12 NM_021047.2_3 - 0.88 9.5 46.7 0.67 9.9 1.8 7.5 7 1 0 7 7 7 0 Adenylate kinase, active site lid Desulfoferrod_N PF06397.10 NM_021047.2_3 - 1.8 8.1 57.2 25 4.4 0.1 12.5 12 0 0 12 12 12 0 Desulfoferrodoxin, N-terminal domain DNA_RNApol_7kD PF03604.11 NM_021047.2_3 - 6.1 6.5 49.4 16 5.1 0.3 11.4 11 0 0 11 11 11 0 DNA directed RNA polymerase, 7 kDa subunit 7tm_2 PF00002.22 NM_001145771.2_2 - 8e-28 97.2 15.9 1.2e-27 96.6 15.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 NM_001145771.2_2 - 1.3e-12 48.0 3.1 1.3e-12 48.0 3.1 2.2 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif UCR_14kD PF02271.14 NM_001199975.2_3 - 9.9e-39 131.2 1.1 1.5e-38 130.7 1.1 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Neur_chan_memb PF02932.14 NM_000743.4_1 - 2.8e-93 312.2 1.9 3.6e-93 311.9 1.9 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 NM_000743.4_1 - 1.4e-74 250.0 2.0 2e-74 249.6 2.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Oxysterol_BP PF01237.16 NM_014835.3_2 - 1.6e-144 481.2 0.0 2e-144 480.9 0.0 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein Flavi_NS5 PF00972.18 NM_014835.3_2 - 0.19 10.0 0.1 0.26 9.4 0.1 1.1 1 0 0 1 1 1 0 Flavivirus RNA-directed RNA polymerase INT_SG_DDX_CT_C PF15300.4 NM_001017435.1_3 - 4.7e-25 87.0 2.0 7.5e-25 86.4 2.0 1.3 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus Dynein_heavy PF03028.13 NM_207437.3_2 - 5.5e-242 804.9 0.2 2.4e-241 802.8 0.0 2.2 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.11 NM_207437.3_2 - 2.4e-138 461.4 6.5 2.4e-138 461.4 6.5 5.5 6 1 1 7 7 7 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.10 NM_207437.3_2 - 2.1e-134 449.1 6.4 1.9e-79 267.7 1.5 3.3 1 1 1 2 2 2 2 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.5 NM_207437.3_2 - 2.1e-101 338.3 0.2 1.3e-100 335.8 0.1 2.1 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.5 NM_207437.3_2 - 5e-86 287.2 0.7 5e-86 287.2 0.7 4.2 4 0 0 4 4 3 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 NM_207437.3_2 - 2.2e-83 279.4 0.0 4.6e-83 278.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 NM_207437.3_2 - 9.8e-60 202.0 0.1 2.9e-59 200.5 0.1 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.5 NM_207437.3_2 - 4.3e-52 177.1 12.7 7.4e-52 176.3 12.7 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 NM_207437.3_2 - 2.8e-24 85.6 5.2 1.3e-06 28.3 0.0 6.6 6 1 0 6 6 6 4 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 NM_207437.3_2 - 4.5e-08 33.3 0.7 0.017 15.2 0.0 5.4 4 1 0 4 4 4 1 AAA domain AAA_16 PF13191.4 NM_207437.3_2 - 1.1e-05 25.8 0.4 4 7.7 0.0 5.7 4 1 1 5 5 5 1 AAA ATPase domain AAA PF00004.27 NM_207437.3_2 - 1.9e-05 25.0 0.1 0.79 10.0 0.0 5.3 5 0 0 5 5 5 1 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.14 NM_207437.3_2 - 0.0002 21.2 1.9 0.023 14.5 0.0 4.1 4 0 0 4 4 4 1 Protein of unknown function, DUF258 RNA_helicase PF00910.20 NM_207437.3_2 - 0.0029 17.8 0.1 22 5.3 0.0 3.8 3 0 0 3 3 3 0 RNA helicase AAA_18 PF13238.4 NM_207437.3_2 - 0.0034 17.8 0.2 0.22 11.9 0.0 4.0 4 0 0 4 4 3 1 AAA domain Spo7_2_N PF15407.4 NM_207437.3_2 - 0.023 14.2 0.0 0.22 11.1 0.0 2.6 2 0 0 2 2 2 0 Sporulation protein family 7 Plasmid_RAQPRD PF09686.8 NM_207437.3_2 - 0.057 13.5 0.9 5.1 7.3 0.0 3.9 3 0 0 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) T2SSE PF00437.18 NM_207437.3_2 - 0.059 12.3 0.7 14 4.5 0.2 3.0 2 0 0 2 2 2 0 Type II/IV secretion system protein COMM_domain PF07258.12 NM_207437.3_2 - 0.26 11.3 2.1 0.89 9.6 0.1 3.0 2 0 0 2 2 2 0 COMM domain AAA_33 PF13671.4 NM_207437.3_2 - 1.1 9.2 2.9 32 4.5 0.1 4.0 5 0 0 5 5 5 0 AAA domain MBT PF02820.16 NM_001172218.1_1 - 4.2e-49 164.7 0.0 1.8e-25 89.0 0.0 2.4 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 NM_001172218.1_1 - 3e-36 124.2 0.1 5.2e-36 123.4 0.1 1.4 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.28 NM_001172218.1_1 - 1e-16 60.9 0.1 1.8e-16 60.2 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.1 NM_001172218.1_1 - 4.7e-13 49.5 17.6 1.4e-12 48.0 17.6 1.9 1 0 0 1 1 1 1 RNA binding Region SAM_2 PF07647.15 NM_001172218.1_1 - 1.4e-07 31.4 0.0 2.8e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_001172218.1_1 - 0.00087 19.1 0.0 0.0023 17.7 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain zf-H2C2_2 PF13465.4 NM_001080409.2_1 - 3.1e-06 27.2 2.7 3.1e-06 27.2 2.7 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001080409.2_1 - 0.0014 18.8 0.3 0.0014 18.8 0.3 3.5 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_001080409.2_1 - 0.035 14.0 0.5 0.11 12.3 0.5 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_001080409.2_2 - 4e-64 210.2 130.0 1.8e-08 34.3 0.6 18.1 18 1 0 18 18 18 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001080409.2_2 - 2.9e-48 159.6 100.4 1.6e-05 24.9 1.7 19.5 19 0 0 19 19 19 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001080409.2_2 - 3.5e-17 61.5 95.4 0.011 16.4 0.4 17.1 18 0 0 18 18 18 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001080409.2_2 - 1.3e-08 34.5 98.8 0.0043 16.8 0.6 16.6 17 0 0 17 17 17 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001080409.2_2 - 2.8e-05 24.0 77.2 0.2 11.6 4.5 12.0 7 3 5 13 13 13 7 Zinc ribbon domain XPA_N PF01286.16 NM_001080409.2_2 - 0.00017 21.4 85.9 1.2 9.1 0.2 15.2 16 0 0 16 16 16 8 XPA protein N-terminal zf-C2H2_11 PF16622.3 NM_001080409.2_2 - 0.0048 16.5 50.1 0.12 12.0 0.1 11.0 12 0 0 12 12 12 5 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 NM_001080409.2_2 - 0.0049 17.0 80.6 0.05 13.8 0.1 13.9 15 0 0 15 15 15 7 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.4 NM_001080409.2_3 - 1.6e-199 638.2 312.2 1.9e-08 34.2 1.0 38.6 40 0 0 40 40 38 32 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001080409.2_3 - 1.4e-121 390.5 224.4 1.6e-05 24.9 1.6 33.9 34 0 0 34 34 34 28 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001080409.2_3 - 1e-55 181.4 215.6 0.011 16.3 0.3 31.5 31 0 0 31 31 31 26 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001080409.2_3 - 2.4e-30 103.8 190.5 0.0041 16.9 1.0 30.5 30 0 0 30 30 30 15 C2H2-type zinc finger XPA_N PF01286.16 NM_001080409.2_3 - 1.9e-21 75.6 167.7 1.1 9.2 0.2 31.1 32 0 0 32 32 32 17 XPA protein N-terminal KRAB PF01352.25 NM_001080409.2_3 - 1.3e-20 72.7 1.2 2.6e-20 71.7 1.2 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001080409.2_3 - 9.6e-17 60.7 156.0 0.038 14.2 0.1 28.5 29 0 0 29 29 28 11 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_001080409.2_3 - 1.2e-16 60.0 116.6 0.43 10.3 0.1 27.9 30 0 0 30 30 30 11 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 NM_001080409.2_3 - 1.4e-13 50.6 193.2 0.019 14.9 4.2 24.7 11 5 18 29 29 29 16 Zinc ribbon domain DUF2790 PF10976.6 NM_001080409.2_3 - 0.00087 19.1 0.3 22 5.0 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF2790) BHD_1 PF10403.7 NM_001080409.2_3 - 0.065 12.9 37.9 85 3.0 0.0 15.4 14 2 3 17 17 17 0 Rad4 beta-hairpin domain 1 7tm_1 PF00001.19 NM_004230.3_1 - 3e-30 105.2 21.7 3e-30 105.2 21.7 2.1 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_004230.3_1 - 8.4e-05 21.9 12.1 8.4e-05 21.9 12.1 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx zf-C2H2_11 PF16622.3 NM_001318727.1_1 - 8.5e-18 63.7 61.7 3.3e-16 58.6 3.8 9.5 10 0 0 10 10 10 5 zinc-finger C2H2-type zf-C2H2 PF00096.24 NM_001318727.1_1 - 3.8e-15 55.3 121.5 0.0033 17.7 0.5 16.1 15 0 0 15 15 15 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001318727.1_1 - 2.4e-09 37.1 122.8 0.0029 18.1 0.3 16.4 17 0 0 17 17 17 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001318727.1_1 - 5.6e-06 26.0 0.2 5.6e-06 26.0 0.2 11.3 13 0 0 13 13 13 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001318727.1_1 - 8.3e-06 25.8 1.8 0.00059 19.9 0.2 9.9 12 0 0 12 12 12 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001318727.1_1 - 0.014 15.7 0.2 0.014 15.7 0.2 10.6 10 0 0 10 10 10 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 NM_001318727.1_1 - 7.3 7.1 86.3 0.094 13.1 1.2 14.0 15 1 0 15 15 15 0 Zinc-finger double domain Ig_2 PF13895.4 NM_001004340.3_3 - 1.1e-09 38.3 0.0 2.1e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_001004340.3_3 - 0.0019 18.6 0.0 0.0042 17.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain PIRT PF15099.4 NM_001004340.3_3 - 0.033 13.6 0.1 0.063 12.7 0.1 1.4 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family V-set PF07686.15 NM_001004340.3_3 - 0.18 11.9 0.1 0.18 11.9 0.1 2.1 2 1 0 2 2 2 0 Immunoglobulin V-set domain 2TM PF13239.4 NM_001004340.3_3 - 2.9 8.1 6.2 1.5 9.0 0.6 2.4 2 0 0 2 2 2 0 2TM domain XPG_I PF00867.16 NM_182625.4_3 - 6.4e-26 90.4 0.9 1.3e-25 89.4 0.0 2.2 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.15 NM_182625.4_3 - 1.3e-12 47.9 0.0 2.6e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain SpoU_methylas_C PF12105.6 NM_182625.4_3 - 0.077 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 SpoU, rRNA methylase, C-terminal Plexin_cytopl PF08337.10 NM_005761.2_1 - 4.8e-200 665.8 11.7 1.8e-197 657.3 11.7 2.1 1 1 0 1 1 1 1 Plexin cytoplasmic RasGAP domain PSI PF01437.23 NM_005761.2_1 - 2e-15 56.9 37.7 3.3e-10 40.2 15.9 3.2 2 0 0 2 2 2 2 Plexin repeat TIG PF01833.22 NM_005761.2_1 - 1.5e-11 44.1 10.8 8.8e-06 25.6 0.2 3.2 3 0 0 3 3 3 2 IPT/TIG domain Sema PF01403.17 NM_005761.2_1 - 1.3e-09 37.3 1.1 9.6e-08 31.0 0.0 3.3 3 1 0 3 3 3 1 Sema domain Polyketide_cyc PF03364.18 NM_001320820.1_2 - 7e-22 77.9 0.0 1e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport ABC_membrane_2 PF06472.13 NM_002858.3_1 - 7.4e-102 340.3 6.8 1.1e-101 339.8 6.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.25 NM_002858.3_1 - 4.7e-17 62.7 0.0 8.3e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.4 NM_002858.3_1 - 0.0015 19.0 0.0 0.0029 18.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.17 NM_002858.3_1 - 0.0078 15.5 0.0 0.6 9.4 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 NM_002858.3_1 - 0.02 14.5 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 NM_002858.3_1 - 0.033 13.8 0.0 0.083 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RhoGEF67_u2 PF16614.3 NM_001113513.1_1 - 7.5e-49 164.2 4.9 7.5e-49 164.2 4.9 2.5 2 0 0 2 2 2 1 Unstructured region two on RhoGEF 6 and 7 betaPIX_CC PF16523.3 NM_001113513.1_1 - 2.6e-40 136.0 9.8 2.6e-40 136.0 9.8 2.3 3 0 0 3 3 2 1 betaPIX coiled coil RhoGEF PF00621.18 NM_001113513.1_1 - 2.8e-32 112.3 2.1 2.8e-32 112.3 2.1 1.8 2 0 0 2 2 2 1 RhoGEF domain SH3_9 PF14604.4 NM_001113513.1_1 - 2e-18 65.8 0.0 4.5e-17 61.5 0.1 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 NM_001113513.1_1 - 6.3e-18 64.1 0.4 1.3e-17 63.1 0.4 1.6 1 0 0 1 1 1 1 Variant SH3 domain RhoGEF67_u1 PF16615.3 NM_001113513.1_1 - 9.6e-17 61.2 1.4 9.6e-17 61.2 1.4 2.5 2 0 0 2 2 1 1 Unstructured region one on RhoGEF 6 and 7 SH3_1 PF00018.26 NM_001113513.1_1 - 1.5e-16 59.6 0.7 6.7e-16 57.5 0.1 2.2 2 0 0 2 2 2 1 SH3 domain PH PF00169.27 NM_001113513.1_1 - 9e-09 35.7 0.0 2e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 PH domain Mucin_bdg PF03272.11 NM_001113513.1_1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative mucin or carbohydrate-binding module THOC7 PF05615.11 NM_001113513.1_1 - 0.2 11.8 6.1 6.3 7.0 0.3 2.6 2 0 0 2 2 2 0 Tho complex subunit 7 GlutR_dimer PF00745.18 NM_001113513.1_1 - 0.37 11.1 3.8 1.1 9.6 3.8 1.8 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain AKNA PF12443.6 NM_001113513.1_1 - 3.2 8.3 6.3 4.1 8.0 0.2 2.8 2 0 0 2 2 2 0 AT-hook-containing transcription factor Cep57_MT_bd PF06657.11 NM_001113513.1_1 - 6.4 7.2 11.0 4.8 7.6 3.9 2.8 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 HEAT PF02985.20 NM_207414.2_1 - 4.7e-08 32.5 1.9 0.081 13.1 0.0 6.7 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.5 NM_207414.2_1 - 0.015 15.1 0.0 1.1 9.2 0.0 3.7 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 NM_207414.2_1 - 1.8 9.0 14.4 12 6.4 0.0 5.2 6 0 0 6 6 6 0 HEAT-like repeat HSF_DNA-bind PF00447.15 NM_016153.2_3 - 1.1e-19 70.6 2.9 1.7e-19 70.1 2.9 1.2 1 0 0 1 1 1 1 HSF-type DNA-binding NAD-GH PF10712.7 NM_016153.2_3 - 0.00059 18.3 0.0 0.00084 17.8 0.0 1.1 1 0 0 1 1 1 1 NAD-specific glutamate dehydrogenase RhoGEF PF00621.18 NM_001001669.2_2 - 8.5e-35 120.5 0.6 1.4e-34 119.8 0.6 1.4 1 0 0 1 1 1 1 RhoGEF domain BAR PF03114.16 NM_001001669.2_2 - 3e-12 46.6 1.4 8.9e-10 38.5 1.4 2.3 1 1 0 1 1 1 1 BAR domain SH3_9 PF14604.4 NM_001001669.2_2 - 5.1e-12 45.3 0.1 7.7e-08 31.9 0.0 2.8 3 0 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.15 NM_001001669.2_2 - 1.2e-11 44.0 0.0 3.2e-05 23.4 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 NM_001001669.2_2 - 2.9e-10 39.5 0.0 4.4e-08 32.5 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_3 PF08239.9 NM_001001669.2_2 - 8.3e-07 29.1 0.0 0.0002 21.4 0.0 2.7 2 0 0 2 2 2 1 Bacterial SH3 domain P4Ha_N PF08336.9 NM_001001669.2_2 - 0.55 10.1 3.2 14 5.5 0.2 3.0 3 0 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 7tm_1 PF00001.19 NM_182647.3_3 - 2.4e-60 203.9 12.4 3.1e-60 203.5 12.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_182647.3_3 - 6.1e-12 45.3 9.9 8e-12 44.9 9.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 NM_182647.3_3 - 1.1e-08 34.7 2.0 1.1e-08 34.7 2.0 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 NM_182647.3_3 - 6.8e-07 29.2 12.0 4.8e-06 26.4 12.0 1.9 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 NM_182647.3_3 - 3.1e-05 23.3 4.5 5.3e-05 22.5 4.5 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx PqiA PF04403.11 NM_182647.3_3 - 0.013 15.2 0.5 0.013 15.2 0.5 1.8 2 0 0 2 2 2 0 Paraquat-inducible protein A Asp PF00026.21 NM_001207049.1_1 - 7.1e-27 94.5 0.0 3.9e-25 88.8 0.0 2.1 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.4 NM_001207049.1_1 - 2.5e-10 40.2 0.0 4.3e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal zf-H2C2_2 PF13465.4 NM_001324350.1_3 - 7.4e-60 196.7 74.6 3.5e-08 33.4 0.5 10.5 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001324350.1_3 - 1e-50 167.3 70.1 5.7e-06 26.4 1.1 10.2 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001324350.1_3 - 9.4e-27 91.2 64.5 0.0045 17.6 0.4 10.3 10 0 0 10 10 10 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001324350.1_3 - 4.3e-08 33.0 51.7 0.005 16.8 2.9 7.5 5 4 5 10 10 10 6 Zinc ribbon domain C1_4 PF07975.10 NM_001324350.1_3 - 9.5e-08 32.1 34.7 0.42 10.8 0.6 8.4 1 1 4 7 7 7 6 TFIIH C1-like domain zf-C2H2_6 PF13912.4 NM_001324350.1_3 - 2.5e-07 30.3 42.8 1.5 8.8 0.2 9.6 9 0 0 9 9 9 6 C2H2-type zinc finger XPA_N PF01286.16 NM_001324350.1_3 - 7.3e-07 29.0 42.5 2.5 8.1 0.4 9.8 10 0 0 10 10 10 4 XPA protein N-terminal CpXC PF14353.4 NM_001324350.1_3 - 4.5e-06 26.5 27.5 2.3 8.1 0.1 9.2 4 2 5 10 10 10 2 CpXC protein zf-C2HC_2 PF13913.4 NM_001324350.1_3 - 2.6e-05 23.9 23.6 1.3 8.9 0.0 8.0 7 0 0 7 7 7 3 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 NM_001324350.1_3 - 0.0017 18.5 24.5 6.9 7.0 0.0 8.3 9 0 0 9 9 8 2 Zinc-finger double-stranded RNA-binding Pectate_lyase22 PF14583.4 NM_001324350.1_3 - 0.0095 14.5 0.0 0.049 12.2 0.0 1.8 2 0 0 2 2 2 1 Oligogalacturonate lyase zinc_ribbon_15 PF17032.3 NM_001324350.1_3 - 0.099 13.3 43.9 0.51 11.0 1.3 6.2 2 2 5 7 7 7 0 zinc-ribbon family DUF3268 PF11672.6 NM_001324350.1_3 - 0.11 12.7 30.5 1.1 9.5 1.1 5.3 1 1 8 9 9 9 0 zinc-finger-containing domain zf-C2H2_11 PF16622.3 NM_001324350.1_3 - 0.2 11.3 49.4 0.49 10.1 0.2 9.5 9 0 0 9 9 9 0 zinc-finger C2H2-type HypA PF01155.17 NM_001324350.1_3 - 0.29 11.0 34.5 5.9 6.8 0.7 5.7 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-trcl PF13451.4 NM_001324350.1_3 - 4.5 7.1 29.7 13 5.7 0.1 8.6 9 0 0 9 9 9 0 Probable zinc-ribbon domain Ion_trans PF00520.29 NM_001129837.1_2 - 1.2e-257 849.8 85.5 1.3e-71 240.6 2.3 4.2 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 NM_001129837.1_2 - 5.4e-37 128.2 12.3 7.4e-27 94.8 0.0 3.0 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 NM_001129837.1_2 - 6.1e-36 121.9 0.0 1.2e-35 121.0 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 NM_001129837.1_2 - 8e-27 93.2 0.0 2e-26 91.9 0.0 1.7 1 1 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 NM_001129837.1_2 - 1.2e-07 30.7 80.5 3.6e-06 25.8 3.9 7.9 7 2 2 9 9 9 4 Polycystin cation channel LRAT PF04970.11 NM_001128203.1_2 - 7.2e-41 139.3 0.0 9.4e-41 139.0 0.0 1.1 1 0 0 1 1 1 1 Lecithin retinol acyltransferase Calici_PP_N PF08405.9 NM_001128203.1_2 - 0.014 14.1 0.0 0.02 13.6 0.0 1.2 1 0 0 1 1 1 0 Viral polyprotein N-terminal PCI PF01399.25 NM_001316358.1_1 - 1.6e-19 70.3 1.6 2.9e-19 69.4 0.2 2.1 2 0 0 2 2 2 1 PCI domain TPR_1 PF00515.26 NM_001316358.1_1 - 0.014 15.1 2.7 0.023 14.4 0.9 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001316358.1_1 - 0.035 14.1 2.1 0.22 11.6 0.9 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.10 NM_001316358.1_1 - 0.096 13.3 1.0 0.24 12.0 1.0 1.7 1 0 0 1 1 1 0 Sel1 repeat TPR_8 PF13181.4 NM_001316358.1_1 - 0.45 10.7 3.5 2.1 8.6 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat fn3 PF00041.19 NM_017559.2_2 - 4.2e-07 30.1 0.0 9e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Interfer-bind PF09294.8 NM_017559.2_2 - 0.01 16.0 0.0 0.061 13.5 0.0 2.1 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.3 NM_017559.2_2 - 0.05 14.0 0.0 0.11 13.0 0.0 1.6 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Ank_4 PF13637.4 NM_001243535.1_3 - 4.3e-22 78.0 2.1 3.1e-10 40.2 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_001243535.1_3 - 5.1e-22 78.1 0.0 1.1e-12 48.3 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 NM_001243535.1_3 - 5.3e-20 70.8 2.9 2.9e-05 24.2 0.1 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.4 NM_001243535.1_3 - 3.5e-15 54.5 0.4 0.0052 17.1 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.4 NM_001243535.1_3 - 5.1e-13 48.9 1.4 2.8e-07 30.6 0.7 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Abi_HHR PF07815.12 NM_001012752.2_3 - 9.3e-35 118.5 0.6 1.6e-34 117.7 0.6 1.3 1 0 0 1 1 1 1 Abl-interactor HHR SH3_1 PF00018.26 NM_001012752.2_3 - 4.9e-16 57.9 0.1 8.1e-16 57.2 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001012752.2_3 - 1.8e-14 53.1 0.1 3.7e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001012752.2_3 - 1.6e-10 40.3 0.1 2.7e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain zf-RING_UBOX PF13445.4 NM_058166.4_2 - 4.8e-12 45.5 4.4 6.8e-12 45.1 2.6 2.3 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 NM_058166.4_2 - 4.7e-11 42.5 7.6 1.9e-10 40.6 7.6 2.2 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 NM_058166.4_2 - 8.2e-10 38.7 0.2 1.6e-09 37.7 0.2 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 NM_058166.4_2 - 2.4e-09 36.8 5.5 7.2e-09 35.2 5.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 NM_058166.4_2 - 7.6e-09 35.4 2.1 7.6e-09 35.4 2.1 3.3 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_2 PF13923.4 NM_058166.4_2 - 3.3e-08 33.1 6.3 3.1e-07 30.0 6.9 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_058166.4_2 - 6.6e-07 29.3 6.5 2.7e-06 27.4 6.5 2.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_058166.4_2 - 2.4e-06 27.3 5.3 2.4e-06 27.3 5.3 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 NM_058166.4_2 - 1.2e-05 24.9 4.4 1.2e-05 24.9 4.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 NM_058166.4_2 - 5.2e-05 22.7 0.1 0.00011 21.6 0.1 1.6 1 0 0 1 1 1 1 SPRY-associated domain FAM76 PF16046.3 NM_058166.4_2 - 0.00032 20.0 8.0 0.00056 19.2 8.0 1.3 1 0 0 1 1 1 1 FAM76 protein zf-RING_10 PF16685.3 NM_058166.4_2 - 0.0064 16.5 2.4 0.026 14.5 2.4 2.1 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-Nse PF11789.6 NM_058166.4_2 - 0.018 14.7 3.2 0.041 13.6 3.2 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-UDP PF14569.4 NM_058166.4_2 - 0.067 13.2 0.6 0.18 11.8 0.6 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.4 NM_058166.4_2 - 0.52 10.1 11.6 0.18 11.6 7.6 2.4 2 1 1 3 3 2 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.4 NM_058166.4_2 - 0.71 9.7 7.0 0.092 12.5 2.1 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein CorA PF01544.16 NM_058166.4_2 - 1.7 7.7 5.2 2.9 7.0 5.2 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein OmpH PF03938.12 NM_058166.4_2 - 2.2 8.1 14.8 3.9 7.3 14.8 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.13 NM_058166.4_2 - 5.1 6.4 6.0 8.3 5.7 6.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fib_alpha PF08702.8 NM_058166.4_2 - 6.5 6.8 17.6 0.17 11.9 11.1 1.6 2 0 0 2 2 1 0 Fibrinogen alpha/beta chain family Pro-kuma_activ PF09286.9 NM_000391.3_2 - 1.2e-31 109.8 0.0 1.8e-31 109.2 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.20 NM_000391.3_2 - 0.0012 18.0 0.1 0.0019 17.4 0.1 1.2 1 0 0 1 1 1 1 Subtilase family Glyco_transf_54 PF04666.11 NM_054013.3_3 - 1.5e-134 447.3 0.0 2e-134 446.8 0.0 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region STAR_dimer PF16544.3 NM_054013.3_3 - 0.14 11.6 0.2 0.36 10.3 0.2 1.6 1 0 0 1 1 1 0 Homodimerisation region of STAR domain protein RFC1 PF08519.10 NM_001204747.1_3 - 6.9e-60 201.6 0.0 1.7e-59 200.4 0.0 1.7 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain BRCT PF00533.24 NM_001204747.1_3 - 1.1e-17 64.1 0.0 2.8e-17 62.8 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.27 NM_001204747.1_3 - 2.3e-14 53.8 0.0 5.2e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PTCB-BRCT PF12738.5 NM_001204747.1_3 - 1.9e-05 24.4 0.0 5.3e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 twin BRCT domain RuvB_N PF05496.10 NM_001204747.1_3 - 0.00053 19.2 0.0 0.0011 18.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 NM_001204747.1_3 - 0.0014 18.5 0.0 0.0027 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 NM_001204747.1_3 - 0.0016 18.7 0.0 0.0047 17.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 NM_001204747.1_3 - 0.0021 18.2 0.0 0.0058 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 NM_001204747.1_3 - 0.0038 17.2 0.0 0.0091 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.4 NM_001204747.1_3 - 0.0049 16.8 0.0 0.014 15.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain BRCT_2 PF16589.3 NM_001204747.1_3 - 0.016 15.4 0.0 0.051 13.8 0.0 1.8 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain RNA_helicase PF00910.20 NM_001204747.1_3 - 0.019 15.2 0.0 0.099 12.9 0.0 2.3 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.4 NM_001204747.1_3 - 0.025 14.9 0.0 0.11 12.9 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.4 NM_001204747.1_3 - 0.037 14.3 2.0 0.058 13.7 0.0 2.4 2 0 0 2 2 1 0 AAA domain zf-CW PF07496.13 NM_001204747.1_3 - 0.049 13.6 0.9 0.42 10.6 0.1 2.4 2 0 0 2 2 2 0 CW-type Zinc Finger Nexin_C PF08628.10 NM_001204747.1_3 - 0.055 14.0 0.3 0.26 11.9 0.3 2.2 1 0 0 1 1 1 0 Sorting nexin C terminal NTPase_1 PF03266.13 NM_001204747.1_3 - 0.055 13.2 0.0 0.16 11.8 0.0 1.7 1 1 0 1 1 1 0 NTPase Complex1_LYR PF05347.13 NM_020408.5_2 - 2.4e-23 81.8 1.3 3.7e-23 81.2 1.3 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 NM_020408.5_2 - 3.2e-07 30.8 0.7 5.2e-07 30.2 0.7 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.4 NM_020408.5_2 - 0.0014 19.0 0.2 0.0023 18.3 0.2 1.3 1 0 0 1 1 1 1 Complex1_LYR-like BK_channel_a PF03493.16 NM_001322836.1_1 - 1.4e-32 111.7 0.2 2.9e-32 110.7 0.2 1.6 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.29 NM_001322836.1_1 - 3.3e-17 62.4 20.1 3.3e-17 62.4 20.1 2.2 3 0 0 3 3 3 1 Ion transport protein Ion_trans_2 PF07885.14 NM_001322836.1_1 - 1.3e-13 50.5 4.1 1.3e-13 50.5 4.1 3.2 4 0 0 4 4 4 1 Ion channel TrkA_N PF02254.16 NM_001322836.1_1 - 6.2e-05 23.1 0.0 0.00029 20.9 0.0 2.0 2 0 0 2 2 2 1 TrkA-N domain SPX PF03105.17 NM_001322836.1_1 - 0.042 13.7 0.1 5.3 6.8 0.1 2.1 2 0 0 2 2 2 0 SPX domain Flavoprotein PF02441.17 NM_001301103.1_1 - 1.8e-17 63.4 0.2 8.7e-13 48.2 0.0 2.2 1 1 1 2 2 2 2 Flavoprotein SHMT PF00464.17 NM_001166357.1_2 - 2e-209 695.0 0.0 2.4e-209 694.7 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Homeobox PF00046.27 NM_001427.3_1 - 6.2e-21 73.8 8.5 1.1e-20 73.1 8.5 1.4 1 0 0 1 1 1 1 Homeobox domain Engrail_1_C_sig PF10525.7 NM_001427.3_1 - 4.9e-17 60.7 1.9 8.7e-17 59.9 1.9 1.4 1 0 0 1 1 1 1 Engrailed homeobox C-terminal signature domain DUF2316 PF10078.7 NM_001427.3_1 - 0.094 12.9 1.2 0.17 12.1 1.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) Homeobox_KN PF05920.9 NM_001427.3_1 - 0.13 12.1 5.4 0.086 12.6 2.7 2.2 2 1 0 2 2 2 0 Homeobox KN domain STOP PF05217.10 NM_001427.3_2 - 0.12 12.5 3.5 0.27 11.4 3.5 1.5 1 0 0 1 1 1 0 STOP protein Laminin_G_2 PF02210.22 NM_001163771.1_1 - 2.2e-08 34.6 0.0 3.6e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.4 NM_001163771.1_1 - 2.5e-05 24.3 0.0 3.2e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.21 NM_001163771.1_1 - 0.00056 20.0 0.0 0.0017 18.5 0.0 1.7 2 0 0 2 2 2 1 Laminin G domain POM121 PF15229.4 NM_001310140.1_1 - 2.7e-24 86.1 4.7 4.7e-24 85.3 4.7 1.3 1 0 0 1 1 1 1 POM121 family Brix PF04427.16 NM_001320309.1_1 - 7.6e-29 101.1 0.0 1.1e-28 100.6 0.0 1.2 1 0 0 1 1 1 1 Brix domain Histone PF00125.22 NM_001042426.1_3 - 1.5e-20 73.8 3.4 1.5e-12 47.9 0.0 2.2 1 1 1 2 2 2 2 Core histone H2A/H2B/H3/H4 Aminotran_3 PF00202.19 NM_001322969.1_2 - 9.7e-119 396.5 0.0 1.2e-118 396.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III NDUF_B6 PF09782.7 NM_182739.2_2 - 4.6e-39 133.9 4.9 8.3e-36 123.3 4.9 2.3 1 1 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Clathrin_bdg PF15045.4 NM_174891.3_1 - 2.6e-36 123.3 0.6 5.5e-36 122.2 0.6 1.6 1 0 0 1 1 1 1 Clathrin-binding box of Aftiphilin, vesicle trafficking 1-cysPrx_C PF10417.7 NM_001291163.1_1 - 0.078 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain of 1-Cys peroxiredoxin EHN PF06441.10 NM_001291163.1_2 - 4.9e-34 116.7 0.4 8.1e-34 116.0 0.4 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.18 NM_001291163.1_2 - 3.4e-33 115.2 0.0 4.6e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold ING PF12998.5 NM_001127584.1_3 - 5.4e-32 110.3 3.7 5.4e-32 110.3 3.7 1.7 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.27 NM_001127584.1_3 - 3.2e-06 26.8 7.6 9.2e-06 25.3 7.6 1.8 1 0 0 1 1 1 1 PHD-finger Spc7 PF08317.9 NM_001127584.1_3 - 0.0036 16.1 8.1 0.005 15.6 8.1 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein zf-HC5HC2H PF13771.4 NM_001127584.1_3 - 0.015 15.4 0.0 0.038 14.1 0.0 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain FlxA PF14282.4 NM_001127584.1_3 - 0.15 11.9 4.8 0.19 11.6 3.6 1.8 1 1 0 1 1 1 0 FlxA-like protein LMBR1 PF04791.14 NM_001127584.1_3 - 3.6 6.3 4.4 5.3 5.7 4.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Anillin_N PF16018.3 NM_001284302.2_3 - 5.7e-47 158.1 13.5 5.8e-39 132.5 0.9 3.9 4 0 0 4 4 4 2 Anillin N-terminus Anillin PF08174.9 NM_001284302.2_3 - 3.9e-39 134.2 0.3 9.6e-39 132.9 0.3 1.7 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.27 NM_001284302.2_3 - 3.3e-17 62.8 0.2 3.3e-17 62.8 0.2 2.1 2 0 0 2 2 2 1 PH domain PIG-Y PF15159.4 NM_001288622.1_2 - 5.7e-11 42.9 6.8 1.5e-10 41.6 6.8 1.8 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Arfaptin PF06456.11 NM_001288622.1_3 - 6.8e-86 287.4 12.3 9.3e-86 287.0 12.3 1.2 1 0 0 1 1 1 1 Arfaptin-like domain ICA69 PF04629.12 NM_001288622.1_3 - 2.6e-69 234.3 14.7 3.9e-69 233.7 14.7 1.3 1 0 0 1 1 1 1 Islet cell autoantigen ICA69, C-terminal domain Trm112p PF03966.14 NM_001288622.1_3 - 2.4e-06 27.9 0.0 5.3e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Trm112p-like protein C2 PF00168.28 NM_003180.2_3 - 1.5e-50 169.6 0.0 2e-24 85.7 0.0 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.4 NM_003180.2_3 - 0.0026 17.2 0.0 0.14 11.6 0.0 2.3 2 0 0 2 2 2 2 CEP76 C2 domain DOCK-C2 PF14429.4 NM_003180.2_3 - 0.028 14.1 0.0 4.7 6.9 0.0 2.2 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins Ras PF00071.20 NM_001144943.1_2 - 3.2e-44 150.3 0.1 4.1e-44 149.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001144943.1_2 - 3.5e-29 101.4 0.0 5.5e-29 100.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001144943.1_2 - 8.7e-14 51.2 0.0 1.3e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001144943.1_2 - 2.3e-06 27.5 0.0 4e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_001144943.1_2 - 0.0089 15.3 0.0 0.012 14.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 NM_001144943.1_2 - 0.031 13.6 0.0 0.046 13.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.21 NM_001144943.1_2 - 0.089 12.7 0.0 2.7 7.9 0.0 2.8 3 0 0 3 3 3 0 Dynamin family TniB PF05621.9 NM_001144943.1_2 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein dsrm PF00035.24 NM_001164383.1_3 - 2.4e-34 117.7 0.6 5.2e-13 49.3 0.1 3.5 3 0 0 3 3 3 3 Double-stranded RNA binding motif Staufen_C PF16482.3 NM_001164383.1_3 - 3.4e-17 62.5 1.5 9e-15 54.7 0.2 4.4 5 1 0 5 5 5 1 Staufen C-terminal domain DND1_DSRM PF14709.5 NM_001164383.1_3 - 0.0031 17.6 0.6 2.2 8.4 0.1 3.9 3 1 0 3 3 3 1 double strand RNA binding domain from DEAD END PROTEIN 1 HAD_2 PF13419.4 NM_031219.3_2 - 1.4e-13 51.2 0.0 1.9e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 NM_031219.3_2 - 1.4e-09 38.4 0.0 1.9e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 NM_031219.3_2 - 0.0039 17.1 0.0 0.0065 16.4 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Pkinase PF00069.23 NM_001081560.2_2 - 2e-51 174.7 0.0 2.7e-51 174.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001081560.2_2 - 3.4e-24 85.4 0.0 4.9e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.8 NM_001081560.2_2 - 6.7e-21 74.0 15.1 1.2e-20 73.2 15.1 1.5 1 0 0 1 1 1 1 DMPK coiled coil domain like Kinase-like PF14531.4 NM_001081560.2_2 - 9.4e-08 31.6 0.0 1.9e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.4 NM_001081560.2_2 - 0.00042 19.9 0.0 0.035 13.6 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 NM_001081560.2_2 - 0.0026 17.0 0.0 0.0056 15.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AP_endonuc_2 PF01261.22 NM_001081560.2_2 - 0.019 14.3 0.4 0.13 11.5 0.1 2.1 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel Laminin_II PF06009.10 NM_001081560.2_2 - 0.23 11.3 2.7 0.46 10.4 2.7 1.4 1 0 0 1 1 1 0 Laminin Domain II Adeno_PIX PF03955.12 NM_001081560.2_2 - 0.37 10.8 6.6 0.93 9.6 6.6 1.6 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) Tmemb_cc2 PF10267.7 NM_001081560.2_2 - 0.82 8.6 5.7 1.2 8.0 5.7 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein APG6 PF04111.10 NM_001081560.2_2 - 1.1 8.4 4.8 1.7 7.8 4.8 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 ZapB PF06005.10 NM_001081560.2_2 - 9.3 6.6 11.5 19 5.7 11.5 1.4 1 0 0 1 1 1 0 Cell division protein ZapB IQ PF00612.25 NM_001322473.1_1 - 0.0035 16.9 0.3 0.0035 16.9 0.3 2.4 2 0 0 2 2 2 1 IQ calmodulin-binding motif Metallophos PF00149.26 NM_001136238.1_1 - 5.3e-11 43.3 0.1 8.8e-11 42.6 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 NM_001136238.1_1 - 2.4e-05 24.5 0.1 3.8e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Mito_carr PF00153.25 NM_031291.3_1 - 5.3e-71 234.5 2.3 4.9e-24 83.9 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Hexokinase_2 PF03727.14 NM_002115.2_3 - 3.4e-146 484.9 0.0 6.5e-83 277.7 0.0 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.19 NM_002115.2_3 - 1.5e-135 449.2 0.0 5.2e-71 238.6 0.0 2.2 2 0 0 2 2 2 2 Hexokinase HTH_Tnp_1 PF01527.18 NM_002115.2_3 - 0.09 13.0 0.0 11 6.3 0.0 2.6 2 0 0 2 2 2 0 Transposase Phage_holin_3_1 PF05106.10 NM_002115.2_3 - 0.16 12.2 0.3 0.95 9.8 0.2 2.2 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) Ion_trans PF00520.29 NM_001129830.2_3 - 2.3e-258 852.2 80.4 1.3e-71 240.6 2.3 4.2 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 NM_001129830.2_3 - 6.1e-36 121.9 0.0 1.2e-35 120.9 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated CAC1F_C PF16885.3 NM_001129830.2_3 - 8.3e-35 121.0 18.0 7.5e-27 94.8 0.0 3.5 3 1 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term Ca_chan_IQ PF08763.9 NM_001129830.2_3 - 5.8e-30 103.3 0.1 1.1e-29 102.3 0.1 1.5 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 NM_001129830.2_3 - 1.6e-09 36.8 31.6 1.1e-08 34.1 8.8 7.5 7 1 0 7 7 7 3 Polycystin cation channel BEX PF04538.10 NM_016303.2_2 - 3.6e-22 79.2 21.3 5.8e-22 78.5 21.3 1.3 1 0 0 1 1 1 1 Brain expressed X-linked like family 7tm_4 PF13853.4 NM_001005213.1_1 - 3.3e-44 151.6 16.6 3.9e-44 151.3 16.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005213.1_1 - 1.4e-15 57.1 17.5 2.7e-15 56.2 17.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Band_7 PF01145.23 NM_013442.2_3 - 7.4e-30 104.1 3.5 1.5e-29 103.2 3.3 1.7 1 1 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.3 NM_013442.2_3 - 2.8e-25 88.0 0.7 6.7e-25 86.8 0.7 1.7 1 0 0 1 1 1 1 C-terminal region of band_7 DUF4769 PF15992.3 NM_013442.2_3 - 0.031 14.0 0.3 0.046 13.4 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) FlgN PF05130.10 NM_013442.2_3 - 0.098 13.0 5.9 0.2 12.0 5.9 1.4 1 0 0 1 1 1 0 FlgN protein Band_7_1 PF13421.4 NM_013442.2_3 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family MH2 PF03166.12 NM_005359.5_2 - 2.5e-77 259.2 0.0 3.6e-77 258.6 0.0 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 NM_005359.5_2 - 3.5e-39 133.0 0.5 7.4e-39 132.0 0.5 1.6 1 0 0 1 1 1 1 MH1 domain NDUF_C2 PF06374.9 NM_001204055.1_2 - 4.4e-30 103.9 0.7 2.3e-17 63.0 0.8 2.3 1 1 1 2 2 2 2 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) PEMT PF04191.11 NM_148172.2_3 - 2.7e-32 111.2 3.4 2.7e-32 111.2 3.4 1.5 2 0 0 2 2 2 1 Phospholipid methyltransferase NTP_transf_2 PF01909.21 NM_001171805.1_1 - 3.1e-17 62.5 0.0 5.6e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.17 NM_001171805.1_1 - 1.5e-15 57.0 0.0 2.7e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase F-box-like PF12937.5 NM_001142958.1_3 - 5.4e-11 42.1 0.0 1.3e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_001142958.1_3 - 6e-08 32.2 0.5 2e-07 30.6 0.1 2.2 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.3 NM_001142958.1_3 - 0.00054 19.7 2.8 0.0068 16.1 0.0 3.0 2 1 1 3 3 3 1 F-box Anoctamin PF04547.10 NM_001313727.1_3 - 1.4e-158 528.2 18.2 2e-158 527.6 18.2 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 NM_001313727.1_3 - 3.4e-71 239.4 0.4 5e-71 238.9 0.4 1.3 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin MRFAP1 PF15155.4 NM_203462.2_2 - 4.2e-55 185.2 7.4 6.4e-55 184.7 7.4 1.3 1 0 0 1 1 1 1 MORF4 family-associated protein1 Ribosomal_L5 PF00281.17 NM_001199802.1_1 - 4.9e-23 81.1 0.0 2.7e-21 75.5 0.0 2.3 2 0 0 2 2 2 1 Ribosomal protein L5 Ribosomal_L5_C PF00673.19 NM_001199802.1_1 - 1.6e-21 76.1 0.0 2.5e-21 75.5 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Sod_Fe_C PF02777.16 NM_001322817.1_2 - 5.3e-38 129.1 0.0 8.4e-38 128.5 0.0 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.20 NM_001322817.1_2 - 4.9e-32 110.1 3.2 7.2e-32 109.6 3.2 1.2 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Bradykinin PF06753.10 NM_001042697.1_1 - 0.36 10.5 2.6 0.9 9.2 2.6 1.7 1 0 0 1 1 1 0 Bradykinin SWIM PF04434.15 NM_001042697.1_3 - 1.4e-07 30.9 4.1 1.4e-07 30.9 4.1 2.0 2 0 0 2 2 2 1 SWIM zinc finger V-set PF07686.15 NM_001277163.2_2 - 3.2e-14 52.9 0.0 4.4e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001277163.2_2 - 0.02 15.3 0.0 0.036 14.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Podoplanin PF05808.9 NM_001277163.2_2 - 0.032 14.2 0.1 0.048 13.7 0.1 1.3 1 0 0 1 1 1 0 Podoplanin DUF4690 PF15756.3 NM_001277163.2_2 - 0.038 14.5 0.2 0.073 13.6 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4690) I-set PF07679.14 NM_001277163.2_2 - 0.044 13.7 0.0 0.072 13.0 0.0 1.4 1 1 0 1 1 1 0 Immunoglobulin I-set domain LHC PF00556.18 NM_001277163.2_2 - 0.21 11.7 1.8 0.42 10.7 1.8 1.5 1 0 0 1 1 1 0 Antenna complex alpha/beta subunit TAS2R PF05296.11 NM_176887.2_1 - 1.9e-89 299.6 38.0 2.1e-89 299.5 38.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) PAG PF15347.4 NM_176887.2_1 - 0.3 9.9 2.7 0.23 10.3 1.6 1.3 1 1 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched SelK_SelG PF10961.6 NM_170674.4_1 - 1.5 9.3 15.7 4.5 7.8 15.7 1.8 1 0 0 1 1 1 0 Selenoprotein SelK_SelG Meis_PKNOX_N PF16493.3 NM_170674.4_3 - 4.2e-45 151.9 0.2 7.1e-45 151.1 0.2 1.4 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.9 NM_170674.4_3 - 2.4e-20 72.0 1.0 5e-20 71.0 1.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 NM_170674.4_3 - 5.8e-08 32.3 0.4 1.6e-07 30.9 0.4 1.8 1 0 0 1 1 1 1 Homeobox domain Kinesin PF00225.21 NM_001130100.1_3 - 6.8e-108 360.4 0.0 1.3e-107 359.5 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 NM_001130100.1_3 - 4.9e-46 156.3 0.4 1.3e-45 154.8 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding Spc7 PF08317.9 NM_001130100.1_3 - 3e-05 22.9 13.8 3e-05 22.9 13.8 3.2 1 1 2 3 3 3 1 Spc7 kinetochore protein DUF4407 PF14362.4 NM_001130100.1_3 - 0.49 9.6 19.9 0.22 10.7 6.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fez1 PF06818.13 NM_001130100.1_3 - 0.99 9.7 41.8 0.58 10.4 10.8 3.3 2 1 1 3 3 3 0 Fez1 AAA_22 PF13401.4 NM_001130100.1_3 - 1.5 9.0 0.0 1.5 9.0 0.0 3.4 3 1 0 3 3 3 0 AAA domain Pkinase PF00069.23 NM_003583.3_2 - 4.9e-57 193.2 0.0 6.7e-57 192.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_003583.3_2 - 2.6e-21 75.9 0.0 4e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_003583.3_2 - 6.5e-06 26.1 0.0 0.00085 19.2 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.18 NM_003583.3_2 - 0.012 15.1 2.1 0.019 14.4 2.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.12 NM_003583.3_2 - 0.021 14.1 1.2 0.035 13.3 1.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 NM_003583.3_2 - 0.093 12.2 0.8 0.18 11.2 0.8 1.4 1 0 0 1 1 1 0 RIO1 family Somatomedin_B PF01033.15 NM_005807.4_1 - 1e-19 70.5 43.7 2.3e-10 40.5 17.9 2.5 2 0 0 2 2 2 2 Somatomedin B domain Hemopexin PF00045.17 NM_005807.4_1 - 1.7e-13 50.1 7.5 1.2e-09 37.8 0.2 3.9 4 0 0 4 4 4 2 Hemopexin Choline_transpo PF04515.10 NM_001178045.1_1 - 4.7e-109 364.4 27.7 4.7e-109 364.4 27.7 2.7 3 0 0 3 3 3 2 Plasma-membrane choline transporter LRR_8 PF13855.4 NM_001256387.1_2 - 4.7e-24 83.8 16.4 5.6e-09 35.5 0.8 4.6 1 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 NM_001256387.1_2 - 1.4e-23 82.4 18.9 1.6e-06 28.2 0.1 5.6 3 2 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_001256387.1_2 - 4.5e-05 22.9 10.6 0.024 14.0 1.9 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.31 NM_001256387.1_2 - 0.0081 16.4 22.3 31 5.4 0.0 8.6 8 1 0 8 8 8 2 Leucine Rich Repeat bZIP_Maf PF03131.15 NM_001313902.1_1 - 8.7e-16 58.1 2.5 8.7e-16 58.1 2.5 3.0 3 0 0 3 3 3 1 bZIP Maf transcription factor bZIP_1 PF00170.19 NM_001313902.1_1 - 3e-08 33.5 9.9 3e-08 33.5 9.9 3.0 3 0 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001313902.1_1 - 2.8e-05 24.0 7.2 2.8e-05 24.0 7.2 3.3 3 0 0 3 3 3 1 Basic region leucine zipper T3SS_basalb_I PF17001.3 NM_001313902.1_1 - 0.089 13.3 0.3 0.34 11.4 0.3 2.0 1 0 0 1 1 1 0 Type III secretion basal body protein I, YscI, HrpB, PscI V-set PF07686.15 NM_182607.4_3 - 1.2e-17 63.8 0.1 3.4e-14 52.8 0.0 3.0 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_182607.4_3 - 9.6e-16 58.0 0.4 4e-07 30.4 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_182607.4_3 - 4.5e-12 45.8 0.0 2.9e-05 23.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 NM_182607.4_3 - 7.6e-12 45.1 0.0 7.8e-07 29.0 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_182607.4_3 - 9.1e-09 35.4 0.4 0.0016 18.6 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Gly-zipper_Omp PF13488.4 NM_182607.4_3 - 0.11 12.4 0.3 0.2 11.6 0.3 1.3 1 0 0 1 1 1 0 Glycine zipper Trypan_PARP PF05887.9 NM_182607.4_3 - 0.21 11.5 35.8 0.022 14.7 29.1 2.0 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) Ribonuclease_3 PF00636.24 NM_001195573.1_1 - 1.1e-61 205.9 0.0 1.9e-43 147.2 0.0 3.0 2 1 0 2 2 2 2 Ribonuclease III domain PAZ PF02170.20 NM_001195573.1_1 - 5.5e-39 133.0 0.6 1.6e-38 131.5 0.2 2.0 2 0 0 2 2 2 1 PAZ domain Dicer_dimer PF03368.12 NM_001195573.1_1 - 1.4e-24 85.9 0.0 3.9e-24 84.5 0.0 1.8 1 0 0 1 1 1 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.4 NM_001195573.1_1 - 6.8e-19 68.2 0.0 2e-11 44.0 0.1 3.0 3 0 0 3 3 3 2 Ribonuclease-III-like Helicase_C PF00271.29 NM_001195573.1_1 - 1.6e-17 63.7 0.0 4.6e-17 62.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 NM_001195573.1_1 - 8.6e-12 45.0 0.0 1.7e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.13 NM_001195573.1_1 - 1.4e-11 44.5 0.0 3.1e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Caprin-1_C PF12287.6 NM_001002259.2_2 - 1.3e-131 439.5 25.8 1.3e-131 439.5 25.8 3.1 3 1 0 3 3 3 1 Cytoplasmic activation/proliferation-associated protein-1 C term C1q PF00386.19 NM_001002259.2_2 - 1.3e-32 112.5 0.0 2.6e-32 111.6 0.0 1.5 1 0 0 1 1 1 1 C1q domain Sialidase_penC PF12135.6 NM_001002259.2_3 - 0.12 12.0 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 Sialidase enzyme penultimate C terminal domain zf-RING_2 PF13639.4 NM_001077239.1_2 - 2.9e-05 24.1 11.0 7.3e-05 22.8 11.0 1.7 1 0 0 1 1 1 1 Ring finger domain Zn_ribbon_17 PF17120.3 NM_001077239.1_2 - 0.00013 21.4 7.4 0.00025 20.5 7.4 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.5 NM_001077239.1_2 - 0.005 17.0 9.9 0.005 17.0 9.9 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 NM_001077239.1_2 - 0.047 13.4 11.9 0.11 12.2 11.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF4407 PF14362.4 NM_001077239.1_2 - 0.074 12.3 11.4 0.16 11.1 11.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Macoilin PF09726.7 NM_001077239.1_2 - 0.075 11.5 29.6 0.1 11.0 29.6 1.1 1 0 0 1 1 1 0 Transmembrane protein RINGv PF12906.5 NM_001077239.1_2 - 0.22 11.5 9.8 0.47 10.5 9.8 1.6 1 0 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.9 NM_001077239.1_2 - 0.25 11.6 6.4 0.54 10.5 6.4 1.6 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_2 PF13923.4 NM_001077239.1_2 - 0.59 9.9 12.6 1.2 9.0 12.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 NM_001077239.1_2 - 0.65 10.0 5.9 1.4 8.9 5.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.4 NM_001077239.1_2 - 0.91 9.4 10.0 2.2 8.2 10.0 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_001077239.1_2 - 1.3 9.0 10.4 3 7.8 10.4 1.7 1 0 0 1 1 1 0 RING-type zinc-finger DERM PF14704.4 NM_001937.4_1 - 1.2e-35 123.1 10.2 1.6e-35 122.7 10.2 1.2 1 0 0 1 1 1 1 Dermatopontin DUF1725 PF08333.9 NM_018349.3_1 - 0.00098 18.6 0.1 0.004 16.6 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1725) C2 PF00168.28 NM_018349.3_3 - 6e-57 190.2 0.0 8.1e-21 74.1 0.0 3.4 3 0 0 3 3 3 3 C2 domain PRT_C PF08372.8 NM_018349.3_3 - 1.4e-08 34.5 0.3 4.2e-08 33.0 0.2 1.7 1 1 1 2 2 2 1 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.10 NM_018349.3_3 - 0.00024 20.5 1.4 0.00041 19.7 1.4 1.3 1 0 0 1 1 1 1 Plant protein of unknown function (DUF639) Tom22 PF04281.11 NM_018349.3_3 - 0.001 18.7 0.1 0.002 17.8 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 CEP76-C2 PF15627.4 NM_018349.3_3 - 0.0096 15.4 0.0 0.14 11.6 0.0 2.2 2 0 0 2 2 2 1 CEP76 C2 domain 7tm_2 PF00002.22 NM_001256255.1_1 - 1.3e-64 217.7 26.6 1.9e-64 217.2 26.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) EGF_CA PF07645.13 NM_001256255.1_1 - 1.2e-12 47.6 25.1 7e-08 32.4 5.2 3.9 3 0 0 3 3 3 2 Calcium-binding EGF domain cEGF PF12662.5 NM_001256255.1_1 - 1.5e-11 43.9 20.2 6.2e-07 29.1 1.4 3.8 4 0 0 4 4 4 2 Complement Clr-like EGF-like GPS PF01825.19 NM_001256255.1_1 - 2.3e-08 34.4 1.5 2.3e-08 34.4 1.5 3.0 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif EGF_3 PF12947.5 NM_001256255.1_1 - 8.1e-08 32.2 19.8 0.00015 21.7 2.8 3.5 3 0 0 3 3 3 2 EGF domain Plasmod_Pvs28 PF06247.9 NM_001256255.1_1 - 0.00078 19.6 25.3 0.0046 17.1 2.0 4.2 4 0 0 4 4 4 2 Pvs28 EGF domain EGF PF00008.25 NM_001256255.1_1 - 0.025 14.7 19.1 0.42 10.8 4.5 3.3 2 0 0 2 2 2 0 EGF-like domain EGF_MSP1_1 PF12946.5 NM_001256255.1_1 - 0.058 13.3 21.0 0.046 13.6 3.5 3.2 3 0 0 3 3 3 0 MSP1 EGF domain 1 FXa_inhibition PF14670.4 NM_001256255.1_1 - 0.077 13.2 26.1 0.071 13.3 5.7 3.8 3 0 0 3 3 3 0 Coagulation Factor Xa inhibitory site hEGF PF12661.5 NM_001256255.1_1 - 0.15 12.6 26.1 0.033 14.7 3.6 3.8 4 0 0 4 4 4 0 Human growth factor-like EGF HCV_NS2 PF01538.16 NM_003627.5_1 - 0.086 12.4 0.2 0.14 11.7 0.2 1.2 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 MFS_1 PF07690.14 NM_003627.5_2 - 7.2e-14 51.3 17.9 7.2e-14 51.3 17.9 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily cNMP_binding PF00027.27 NM_006702.4_2 - 3.1e-51 171.2 0.1 7.5e-17 61.0 0.0 3.5 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Patatin PF01734.20 NM_006702.4_2 - 1.9e-23 83.6 0.1 4e-23 82.5 0.1 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase Ets PF00178.20 NM_001114309.1_1 - 1.7e-30 105.2 1.4 3.1e-30 104.3 1.4 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 NM_001114309.1_1 - 4.8e-23 80.8 0.1 1.1e-22 79.6 0.1 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain AT_hook PF02178.17 NM_001114309.1_1 - 0.42 10.5 5.1 1.1 9.2 5.1 1.8 1 0 0 1 1 1 0 AT hook motif GoLoco PF02188.15 NM_013296.4_2 - 1.7e-38 129.4 32.1 6.8e-10 38.1 0.2 4.6 4 0 0 4 4 4 4 GoLoco motif TPR_12 PF13424.4 NM_013296.4_2 - 6.6e-38 128.7 28.6 5.8e-11 42.4 5.7 5.4 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.26 NM_013296.4_2 - 3.2e-34 115.2 29.5 7.9e-06 25.3 0.0 7.9 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.4 NM_013296.4_2 - 5e-29 98.0 19.8 1.2e-05 24.8 0.4 8.2 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 NM_013296.4_2 - 1e-20 72.0 22.2 0.0018 18.1 0.7 7.8 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.4 NM_013296.4_2 - 1.5e-19 68.4 19.9 0.00047 20.0 0.5 7.7 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.4 NM_013296.4_2 - 7.1e-18 63.7 21.0 0.0078 15.9 0.0 7.9 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_4 PF07721.12 NM_013296.4_2 - 4.7e-08 32.8 0.0 0.89 10.2 0.1 6.0 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_013296.4_2 - 2e-05 24.9 4.4 18 6.4 0.0 6.8 5 2 2 7 7 7 0 Tetratricopeptide repeat Rapsyn_N PF10579.7 NM_013296.4_2 - 4.1e-05 23.5 0.9 8.2 6.5 0.1 4.5 3 2 2 5 5 5 2 Rapsyn N-terminal myristoylation and linker region TPR_16 PF13432.4 NM_013296.4_2 - 0.00031 21.2 11.5 1.4 9.5 0.2 5.9 4 1 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_013296.4_2 - 0.011 16.2 1.6 75 4.2 0.1 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_17 PF13431.4 NM_013296.4_2 - 0.015 15.5 14.2 28 5.3 0.0 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.4 NM_013296.4_2 - 0.02 14.4 21.9 0.36 10.4 0.4 6.9 6 1 0 6 6 6 0 TPR repeat ANAPC3 PF12895.5 NM_013296.4_2 - 0.076 13.1 12.1 4.5 7.4 2.3 4.5 3 1 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 MITF_TFEB_C_3_N PF15951.3 NM_006722.2_2 - 1.5e-50 171.7 15.7 1.5e-50 171.7 15.7 2.0 2 0 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 NM_006722.2_2 - 6.7e-37 127.2 0.9 6.7e-37 127.2 0.9 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF3371) HLH PF00010.24 NM_006722.2_2 - 2.4e-16 59.3 0.5 5e-16 58.3 0.5 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TFIIA PF03153.11 NM_006722.2_2 - 8.5 6.1 16.1 13 5.5 16.1 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SIT PF15330.4 NM_001289084.1_3 - 4.9e-34 117.1 0.7 8.7e-34 116.3 0.7 1.4 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT V-set PF07686.15 NM_001289084.1_3 - 5.2e-12 45.7 0.9 9.2e-12 45.0 0.9 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain TMEM154 PF15102.4 NM_001289084.1_3 - 0.0053 16.5 1.1 0.01 15.6 0.1 1.9 2 0 0 2 2 2 1 TMEM154 protein family ig PF00047.23 NM_001289084.1_3 - 0.16 12.0 2.9 1.2 9.3 2.9 2.2 1 1 0 1 1 1 0 Immunoglobulin domain QRPTase_C PF01729.17 NM_001318249.1_3 - 1e-30 106.6 0.0 1.4e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain Defensin_beta_2 PF13841.4 NM_001302695.1_3 - 0.00012 22.3 9.8 0.00036 20.8 9.8 1.9 1 0 0 1 1 1 1 Beta defensin Ammonium_transp PF00909.19 NM_001256396.1_3 - 7.3e-71 238.8 22.1 1e-70 238.3 22.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family C2 PF00168.28 NM_001184796.1_2 - 6.5e-95 312.1 0.0 4.2e-24 84.7 0.0 5.3 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.3 NM_001184796.1_2 - 4.2e-78 260.8 0.1 6.6e-78 260.2 0.1 1.3 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain LTD PF00932.17 NM_001256266.1_2 - 3.7e-11 43.2 0.0 1.8e-10 41.0 0.0 2.0 2 0 0 2 2 2 1 Lamin Tail Domain HLH PF00010.24 NM_032827.6_3 - 1.2e-13 50.7 0.3 2e-13 50.0 0.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Tubulin PF00091.23 NM_001303525.1_1 - 1.2e-20 74.5 0.0 1.7e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.7 NM_001303525.1_1 - 1.2e-05 25.5 0.0 2.4e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Lysyl_oxidase PF01186.15 NM_002318.2_1 - 2.5e-102 340.7 5.5 4e-102 340.0 5.5 1.3 1 0 0 1 1 1 1 Lysyl oxidase SRCR PF00530.16 NM_002318.2_1 - 7e-92 302.3 39.8 4.6e-29 100.7 4.1 5.4 5 0 0 5 5 5 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 NM_002318.2_1 - 1.9e-17 63.5 16.8 0.00026 21.3 0.3 4.7 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Trypsin PF00089.24 NM_144507.2_1 - 1.2e-15 57.8 1.1 1.6e-15 57.4 1.1 1.2 1 0 0 1 1 1 1 Trypsin LRR_8 PF13855.4 NM_001144005.2_2 - 3.2e-43 145.2 45.5 2.4e-16 59.1 1.3 6.4 2 2 5 7 7 7 6 Leucine rich repeat LRR_5 PF13306.4 NM_001144005.2_2 - 2.4e-17 63.0 0.0 2.1e-07 30.8 0.0 2.3 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_001144005.2_2 - 3.3e-17 62.1 44.5 6.8e-05 23.0 0.6 8.5 7 1 0 8 8 8 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001144005.2_2 - 3.1e-05 23.7 30.2 3.5 8.3 0.0 10.7 10 1 0 10 10 10 2 Leucine Rich Repeat LRRNT PF01462.16 NM_001144005.2_2 - 0.0008 18.9 9.0 0.0014 18.1 2.3 3.0 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 NM_001144005.2_2 - 0.0018 17.7 13.7 2 7.7 0.1 4.1 2 2 3 5 5 5 4 Leucine-rich repeat Septin PF00735.16 NM_001321515.1_1 - 1.2e-96 323.2 1.8 2.1e-96 322.3 1.8 1.4 1 0 0 1 1 1 1 Septin AAA_22 PF13401.4 NM_001321515.1_1 - 0.00048 20.3 0.5 0.0036 17.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.21 NM_001321515.1_1 - 0.00093 19.1 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.11 NM_001321515.1_1 - 0.0012 18.9 0.0 0.0026 17.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_001321515.1_1 - 0.0015 18.8 0.0 0.0034 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 NM_001321515.1_1 - 0.0038 17.0 0.2 0.27 11.0 0.0 2.5 2 1 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_001321515.1_1 - 0.0082 15.6 0.2 2.4 7.5 0.1 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_29 PF13555.4 NM_001321515.1_1 - 0.046 13.3 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Atg14 PF10186.7 NM_001321515.1_1 - 0.052 12.5 7.1 0.088 11.7 7.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ABC_tran PF00005.25 NM_001321515.1_1 - 0.12 12.7 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_11 PF13086.4 NM_001321515.1_1 - 4.7 6.7 6.7 7.6 6.0 6.7 1.2 1 0 0 1 1 1 0 AAA domain Kelch_1 PF01344.23 NM_001292003.1_2 - 2.7e-71 234.8 21.6 4.7e-14 51.6 0.1 6.9 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.4 NM_001292003.1_2 - 1.4e-39 132.9 4.9 6.6e-08 32.4 0.0 6.5 4 1 2 6 6 6 6 Kelch motif Kelch_3 PF13415.4 NM_001292003.1_2 - 1e-28 98.8 9.3 7.8e-06 25.9 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain BACK PF07707.13 NM_001292003.1_2 - 1.5e-28 98.8 0.5 2.7e-28 97.9 0.5 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_4 PF13418.4 NM_001292003.1_2 - 1.8e-27 94.9 2.8 1.2e-06 28.2 0.0 6.5 4 2 2 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_001292003.1_2 - 1.2e-26 91.5 9.2 0.00012 21.8 0.1 6.5 6 0 0 6 6 6 6 Kelch motif BTB PF00651.29 NM_001292003.1_2 - 4.9e-24 84.6 0.8 1.3e-23 83.2 0.8 1.7 1 0 0 1 1 1 1 BTB/POZ domain PDZ PF00595.22 NM_032595.4_2 - 6.4e-13 48.7 0.4 1.2e-12 47.9 0.4 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_032595.4_2 - 0.0057 16.8 0.1 0.014 15.6 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Pox_A_type_inc PF04508.10 NM_032595.4_2 - 0.86 9.4 5.7 5.8 6.8 0.4 2.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat HMMR_N PF15905.3 NM_032595.4_2 - 0.99 8.7 25.2 1.7 7.9 25.2 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal CENP-F_leu_zip PF10473.7 NM_032595.4_2 - 1.3 8.9 28.0 0.027 14.4 9.2 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2407_C PF13373.4 NM_032595.4_2 - 4.2 7.4 5.4 9.5 6.3 5.4 1.5 1 0 0 1 1 1 0 DUF2407 C-terminal domain Spc7 PF08317.9 NM_032595.4_2 - 9.7 4.8 25.7 23 3.6 25.7 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein ig PF00047.23 NM_001318830.1_2 - 7.2e-13 48.4 0.2 1.7e-12 47.2 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 NM_001318830.1_2 - 1.7e-06 28.0 0.1 3.8e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001318830.1_2 - 0.00065 20.1 0.1 0.0015 19.0 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_001318830.1_2 - 0.0089 15.9 0.1 0.015 15.2 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_001318830.1_3 - 3.8e-07 30.1 0.1 7.2e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_001318830.1_3 - 0.0072 16.8 0.0 0.014 15.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 NM_001318830.1_3 - 0.01 15.8 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF3544 PF12064.6 NM_183047.3_1 - 2.5e-102 341.4 19.4 2.5e-102 341.4 19.4 4.0 4 1 0 4 4 4 1 Domain of unknown function (DUF3544) Bromodomain PF00439.23 NM_183047.3_1 - 6e-16 58.2 0.0 1.6e-15 56.8 0.0 1.7 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.15 NM_183047.3_1 - 3.7e-07 30.4 0.4 1.9e-06 28.1 0.4 2.4 1 0 0 1 1 1 1 PWWP domain PHD PF00628.27 NM_183047.3_1 - 1.6e-06 27.8 12.9 1.6e-06 27.8 12.9 3.5 3 0 0 3 3 3 1 PHD-finger zf-MYND PF01753.16 NM_183047.3_1 - 0.0025 17.7 17.1 0.0025 17.7 17.1 3.7 3 1 0 3 3 3 1 MYND finger DUF1640 PF07798.9 NM_183047.3_1 - 0.0053 16.7 6.9 0.0053 16.7 6.9 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1640) B9-C2 PF07162.9 NM_001321215.1_2 - 8.2e-48 162.7 0.0 1.2e-47 162.2 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Pou PF00157.15 NM_001207025.2_3 - 2.5e-37 126.6 0.2 4.1e-37 125.9 0.2 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 NM_001207025.2_3 - 4.7e-16 58.2 3.7 9.2e-16 57.3 3.7 1.5 1 0 0 1 1 1 1 Homeobox domain Suf PF05843.12 NM_001207025.2_3 - 3 7.6 10.7 6.4 6.5 10.7 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Peptidase_C69 PF03577.13 NM_014766.4_2 - 2.5e-05 23.5 0.0 3.7e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C69 AAT PF03417.14 NM_014766.4_2 - 0.19 11.3 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Pkinase PF00069.23 NM_032037.3_3 - 1.5e-58 198.1 0.0 1.8e-58 197.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_032037.3_3 - 5.1e-34 117.6 0.0 6.2e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_032037.3_3 - 3.5e-07 29.7 0.0 5.4e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_032037.3_3 - 2.7e-05 23.5 0.0 3.7e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_032037.3_3 - 0.029 14.2 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.20 NM_032037.3_3 - 0.22 11.0 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 RIO1 family RAC_head PF16717.3 NM_014377.1_3 - 2e-21 76.6 12.3 2e-21 76.6 12.3 4.6 5 1 0 5 5 5 1 Ribosome-associated complex head domain Myb_DNA-binding PF00249.29 NM_014377.1_3 - 3.3e-21 75.0 3.9 1e-11 44.6 0.2 3.1 3 0 0 3 3 3 2 Myb-like DNA-binding domain DnaJ PF00226.29 NM_014377.1_3 - 8.5e-15 54.5 0.2 8.5e-15 54.5 0.2 2.6 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-bind_6 PF13921.4 NM_014377.1_3 - 1.2e-11 44.5 0.8 1.2e-06 28.5 0.2 3.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain PLU-1 PF08429.9 NM_006618.4_2 - 2.4e-92 309.5 13.6 1e-89 300.9 5.5 3.2 3 1 1 4 4 4 3 PLU-1-like protein JmjC PF02373.20 NM_006618.4_2 - 9.5e-44 148.4 1.5 1.8e-43 147.5 1.5 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.27 NM_006618.4_2 - 4.2e-27 93.6 32.1 2.3e-11 43.3 4.0 4.3 3 0 0 3 3 3 3 PHD-finger ARID PF01388.19 NM_006618.4_2 - 2.9e-16 59.8 0.0 6.1e-16 58.7 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-C5HC2 PF02928.14 NM_006618.4_2 - 7e-15 55.0 12.4 7e-15 55.0 12.4 2.8 2 0 0 2 2 2 1 C5HC2 zinc finger JmjN PF02375.15 NM_006618.4_2 - 5e-14 51.8 0.8 1e-13 50.8 0.8 1.6 1 0 0 1 1 1 1 jmjN domain PHD_2 PF13831.4 NM_006618.4_2 - 2.8e-06 26.6 22.7 0.0095 15.3 1.8 4.0 3 0 0 3 3 3 3 PHD-finger zf-PHD-like PF15446.4 NM_006618.4_2 - 0.16 11.5 12.2 0.37 10.3 0.4 3.6 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain 7tm_4 PF13853.4 NM_001013354.1_1 - 2.5e-50 171.6 10.1 3e-50 171.4 10.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001013354.1_1 - 8.9e-20 70.9 17.9 8.9e-20 70.9 17.9 2.3 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) PDZ PF00595.22 NM_001114133.2_1 - 1.3e-11 44.6 0.0 2.2e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Calsarcin PF05556.9 NM_001114133.2_1 - 0.0022 17.4 0.0 2 7.7 0.0 2.8 2 1 0 2 2 2 2 Calcineurin-binding protein (Calsarcin) PDZ_2 PF13180.4 NM_001114133.2_1 - 0.012 15.8 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 PDZ domain ABM PF03992.14 NM_022351.4_3 - 7.4e-10 38.7 0.1 1.2e-09 38.1 0.1 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase EF-hand_1 PF00036.30 NM_022351.4_3 - 1.9e-07 30.0 3.2 0.00021 20.5 0.8 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 NM_022351.4_3 - 1.1e-06 28.1 1.2 0.0023 17.5 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.4 NM_022351.4_3 - 1.7e-06 28.3 0.3 0.025 14.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_022351.4_3 - 1.5e-05 24.4 2.9 0.09 12.6 0.3 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 NM_022351.4_3 - 6.8e-05 22.1 1.9 0.00021 20.5 0.6 2.3 1 1 1 2 2 2 1 EF hand PMT PF02366.16 NM_001136114.1_1 - 7.5e-72 241.7 20.8 7.5e-72 241.7 20.8 1.6 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.3 NM_001136114.1_1 - 2.7e-51 173.9 8.4 2.7e-51 173.9 8.4 2.2 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.17 NM_001136114.1_1 - 5e-15 55.7 0.0 7.5e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 MIR domain Cadherin PF00028.15 NM_001184880.1_3 - 1.7e-83 275.1 0.1 3.2e-19 69.0 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_001184880.1_3 - 2.8e-18 65.3 0.2 9.4e-17 60.5 0.0 3.0 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 NM_001184880.1_3 - 0.0049 17.5 0.1 0.018 15.7 0.1 2.0 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal PepSY PF03413.17 NM_001184880.1_3 - 0.39 11.2 2.5 18 5.8 0.3 3.0 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain GAGE PF05831.9 NM_001098418.1_3 - 1.1e-36 125.4 12.3 1.3e-36 125.2 12.3 1.1 1 0 0 1 1 1 1 GAGE protein Dynein_light PF01221.16 NM_003746.2_3 - 3.4e-42 142.5 1.9 4.6e-42 142.1 1.9 1.2 1 0 0 1 1 1 1 Dynein light chain type 1 LIM PF00412.20 NM_001113547.1_2 - 1.3e-11 44.4 5.1 2.2e-11 43.7 5.1 1.4 1 0 0 1 1 1 1 LIM domain Guanylate_kin PF00625.19 NM_000724.3_1 - 1.5e-49 168.0 0.1 2.6e-49 167.2 0.1 1.4 1 0 0 1 1 1 1 Guanylate kinase VGCC_beta4Aa_N PF12052.6 NM_000724.3_1 - 7.3e-23 80.3 6.5 2.8e-22 78.4 6.5 2.1 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.26 NM_000724.3_1 - 0.0067 15.9 0.1 0.016 14.7 0.1 1.6 1 0 0 1 1 1 1 SH3 domain Myosin_head PF00063.19 NM_001101421.3_1 - 3.9e-238 792.0 0.0 5.2e-238 791.5 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 NM_001101421.3_1 - 5.9e-29 100.9 1.0 1e-28 100.2 1.0 1.3 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Zeta_toxin PF06414.10 NM_001101421.3_1 - 0.065 12.4 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.15 NM_001101421.3_1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DJ-1_PfpI PF01965.22 NM_001318818.1_3 - 0.14 11.8 0.0 0.37 10.4 0.0 1.5 2 0 0 2 2 2 0 DJ-1/PfpI family Dynamin_N PF00350.21 NM_130835.2_1 - 3.3e-37 128.0 0.1 3.3e-37 128.0 0.1 2.2 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.21 NM_130835.2_1 - 0.00016 21.6 0.0 0.0011 18.9 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 NM_130835.2_1 - 0.0088 15.5 0.0 0.22 10.9 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF1593 PF07632.9 NM_130835.2_1 - 0.011 15.1 0.1 0.022 14.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) Roc PF08477.11 NM_130835.2_1 - 0.095 12.8 0.0 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NPV_P10 PF05531.10 NM_130835.2_1 - 8.3 6.8 6.3 1.6 9.1 0.4 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Granulin PF00396.16 NM_152291.2_1 - 5.5 7.3 31.2 25 5.2 0.6 6.8 6 0 0 6 6 6 0 Granulin Neur_chan_memb PF02932.14 NM_001166694.1_1 - 1.3e-75 254.4 1.9 1.8e-75 253.9 1.9 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 NM_001166694.1_1 - 5e-75 251.5 2.0 8.4e-75 250.8 2.0 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain TMEM138 PF14935.4 NM_001166694.1_1 - 6 7.4 8.2 12 6.5 8.2 1.4 1 0 0 1 1 1 0 Transmembrane protein 138 Ion_trans PF00520.29 NM_014139.2_2 - 9.4e-245 807.6 99.9 8.8e-71 237.8 16.2 4.1 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.11 NM_014139.2_2 - 1.4e-37 129.7 3.1 4e-37 128.2 3.1 1.8 1 0 0 1 1 1 1 Sodium ion transport-associated PKD_channel PF08016.10 NM_014139.2_2 - 1.4e-10 40.4 91.4 0.011 14.3 2.6 10.0 7 3 2 9 9 9 7 Polycystin cation channel GPHH PF16905.3 NM_014139.2_2 - 2e-06 27.4 0.4 4.6e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated Adeno_E3_14_5 PF04834.10 NM_014139.2_2 - 2.6 8.5 6.8 15 6.1 0.1 3.6 3 0 0 3 3 3 0 Early E3 14.5 kDa protein Aconitase PF00330.18 NM_001320941.1_1 - 1.9e-12 46.8 0.0 2.6e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase PF00330.18 NM_001320941.1_3 - 9.5e-130 433.5 0.0 1.3e-129 433.1 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.17 NM_001320941.1_3 - 9.5e-43 145.6 0.0 1.6e-42 144.8 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Guanylate_cyc PF00211.18 NM_001320613.1_2 - 5.6e-127 420.3 0.1 1.8e-65 219.8 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.3 NM_001320613.1_2 - 1.2e-31 110.2 7.7 1.2e-31 110.2 7.7 1.9 2 0 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region HNOBA PF07701.12 NM_001320613.1_2 - 0.0057 16.0 1.0 0.46 9.8 0.6 2.4 2 0 0 2 2 2 2 Heme NO binding associated fn3_4 PF16794.3 NM_001320613.1_2 - 0.14 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Fibronectin-III type domain Peptidase_S49_N PF08496.8 NM_001320613.1_2 - 0.29 11.1 4.4 0.2 11.6 1.9 2.0 1 1 1 2 2 2 0 Peptidase family S49 N-terminal Atg14 PF10186.7 NM_001303105.1_2 - 0.055 12.4 14.7 0.1 11.5 14.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2968 PF11180.6 NM_001303105.1_2 - 0.061 12.9 7.9 0.12 11.9 7.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Mt_ATP-synt_D PF05873.10 NM_001303105.1_2 - 0.1 12.3 4.5 0.14 11.9 3.1 1.9 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) UPF0184 PF03670.11 NM_001303105.1_2 - 0.12 12.6 2.1 0.3 11.4 2.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Spc7 PF08317.9 NM_001303105.1_2 - 0.23 10.2 18.9 0.42 9.3 18.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein LPP PF04728.11 NM_001303105.1_2 - 1.5 9.1 5.8 0.75 10.1 3.0 1.9 2 0 0 2 2 2 0 Lipoprotein leucine-zipper DB PF01682.17 NM_001316347.1_3 - 0.00015 21.9 27.5 0.013 15.7 16.2 2.3 2 0 0 2 2 2 2 DB module VCX_VCY PF15231.4 NM_001129826.2_3 - 8.1e-06 26.4 3.9 1.2e-05 25.8 3.9 1.1 1 0 0 1 1 1 1 Variable charge X/Y family Neurexophilin PF06312.10 NM_001134456.1_3 - 1.6e-63 213.9 0.0 2.3e-63 213.4 0.0 1.2 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.17 NM_001134456.1_3 - 0.0072 17.0 0.0 0.012 16.3 0.0 1.3 1 0 0 1 1 1 1 Filamin/ABP280 repeat SAM_1 PF00536.28 NM_016561.2_3 - 1.3e-08 35.0 0.0 2.3e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C3HC4_4 PF15227.4 NM_016561.2_3 - 3.2e-08 33.5 12.2 6.4e-08 32.5 12.2 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 NM_016561.2_3 - 9.1e-08 31.7 13.7 1.8e-07 30.8 13.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_016561.2_3 - 1.6e-07 30.9 13.3 3.2e-07 29.9 13.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_016561.2_3 - 5.2e-06 26.1 8.1 1.1e-05 25.1 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_016561.2_3 - 1.7e-05 24.6 10.1 1.7e-05 24.6 10.1 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_016561.2_3 - 4.3e-05 23.6 14.8 9.6e-05 22.4 14.8 1.6 1 0 0 1 1 1 1 Ring finger domain SAM_2 PF07647.15 NM_016561.2_3 - 0.00019 21.4 0.0 0.00034 20.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_016561.2_3 - 0.014 15.2 0.2 0.028 14.3 0.2 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain zf-ANAPC11 PF12861.5 NM_016561.2_3 - 0.042 13.8 4.7 0.094 12.6 4.7 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.4 NM_016561.2_3 - 0.065 13.1 11.9 0.14 12.0 11.9 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.5 NM_016561.2_3 - 0.12 12.6 10.8 0.25 11.5 10.8 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.4 NM_016561.2_3 - 0.27 11.0 10.3 0.65 9.8 10.3 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 NM_016561.2_3 - 2.2 7.9 13.0 0.034 13.7 4.8 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.3 NM_016561.2_3 - 7.9 6.6 13.8 0.1 12.6 6.3 1.7 2 0 0 2 2 1 0 zinc RING finger of MSL2 Pex16 PF08610.8 NM_004813.2_1 - 1.9e-86 290.0 1.2 2.3e-86 289.8 1.2 1.1 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) UNC-93 PF05978.14 NM_018974.3_2 - 2.1e-08 33.9 6.8 2.1e-08 33.9 6.8 2.6 2 1 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_2 PF13347.4 NM_018974.3_2 - 0.00093 17.7 22.4 0.0045 15.5 5.4 3.0 1 1 2 3 3 3 3 MFS/sugar transport protein NADH_dh_m_C1 PF15088.4 NM_001184991.1_1 - 4.7e-32 109.2 0.2 7.7e-32 108.5 0.2 1.4 1 0 0 1 1 1 1 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial GPS2_interact PF15784.3 NM_001190440.1_2 - 4.2e-35 120.2 6.8 4.2e-35 120.2 6.8 4.6 4 0 0 4 4 4 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 NM_001190440.1_2 - 6.4e-18 64.5 0.2 4.4e-12 45.8 0.2 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 NM_001190440.1_2 - 0.0038 17.3 2.0 0.069 13.3 0.3 2.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain AP-5_subunit_s1 PF15001.4 NM_001204447.1_1 - 3.3e-70 235.9 0.0 4.6e-70 235.4 0.0 1.2 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 MHC_I PF00129.16 NM_002127.5_2 - 2.6e-94 313.7 1.5 3.4e-94 313.3 1.5 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_002127.5_2 - 1.4e-15 57.4 0.0 2.8e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 NM_002127.5_2 - 0.00035 20.0 0.0 0.0005 19.5 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 NM_002127.5_2 - 0.052 13.5 0.5 0.093 12.7 0.0 1.7 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain SNO PF01174.17 NM_002127.5_2 - 0.2 11.3 0.0 0.34 10.6 0.0 1.2 1 0 0 1 1 1 0 SNO glutamine amidotransferase family Ras PF00071.20 NM_181532.3_3 - 2.2e-35 121.5 0.0 2.6e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_181532.3_3 - 2.4e-10 40.6 0.0 3.9e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF258 PF03193.14 NM_181532.3_3 - 6.8e-08 32.4 0.0 0.011 15.5 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Arf PF00025.19 NM_181532.3_3 - 4.8e-05 22.7 0.0 9.9e-05 21.7 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_181532.3_3 - 0.0011 19.0 0.0 0.0016 18.3 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_25 PF13481.4 NM_181532.3_3 - 0.0035 16.8 0.1 0.0048 16.4 0.1 1.3 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.25 NM_181532.3_3 - 0.0049 16.3 0.0 0.019 14.3 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ArgK PF03308.14 NM_181532.3_3 - 0.061 12.2 0.2 0.43 9.4 0.1 1.9 2 0 0 2 2 2 0 ArgK protein FeoB_N PF02421.16 NM_181532.3_3 - 0.097 12.1 0.0 1.2 8.5 0.0 2.4 3 0 0 3 3 3 0 Ferrous iron transport protein B ANAPC4_WD40 PF12894.5 NM_020779.3_1 - 9.8e-12 44.9 8.0 4.1e-06 26.9 0.2 6.2 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 NM_020779.3_1 - 0.00028 21.5 0.8 7.5 7.5 0.0 5.0 3 1 0 4 4 4 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.12 NM_020779.3_1 - 0.00038 19.5 4.1 0.0054 15.7 0.0 2.9 3 0 0 3 3 3 2 Coatomer WD associated region Clathrin PF00637.18 NM_020779.3_1 - 0.00086 19.1 1.4 0.0019 17.9 0.6 2.0 1 1 1 2 2 2 1 Region in Clathrin and VPS ArdA PF07275.9 NM_020779.3_1 - 0.13 12.8 0.4 0.27 11.7 0.4 1.5 1 0 0 1 1 1 0 Antirestriction protein (ArdA) eIF2A PF08662.9 NM_020779.3_1 - 0.25 11.1 3.4 0.24 11.1 0.7 2.3 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A MARVEL PF01284.21 NM_144601.3_1 - 2.3e-08 34.1 15.0 3.9e-08 33.3 15.0 1.4 1 0 0 1 1 1 1 Membrane-associating domain ETRAMP PF09716.8 NM_203288.1_1 - 0.002 18.0 7.5 0.24 11.3 0.1 2.4 2 0 0 2 2 2 2 Malarial early transcribed membrane protein (ETRAMP) SR-25 PF10500.7 NM_203288.1_1 - 0.0072 15.8 28.1 0.0072 15.8 28.1 2.8 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein Med19 PF10278.7 NM_203288.1_1 - 0.015 15.1 28.8 0.015 15.1 28.8 2.8 3 0 0 3 3 3 0 Mediator of RNA pol II transcription subunit 19 OLF PF02191.14 NM_001297705.1_1 - 4e-83 278.7 6.0 6.2e-83 278.0 6.0 1.3 1 0 0 1 1 1 1 Olfactomedin-like domain 7tm_2 PF00002.22 NM_001297705.1_1 - 5.3e-68 228.8 23.0 8e-68 228.2 23.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.3 NM_001297705.1_1 - 2.3e-55 187.1 0.8 3.4e-55 186.6 0.8 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Latrophilin PF02354.14 NM_001297705.1_1 - 1.9e-35 122.5 6.4 3.2e-35 121.8 6.4 1.3 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region Gal_Lectin PF02140.16 NM_001297705.1_1 - 7.3e-24 83.9 0.6 2.1e-23 82.4 0.6 1.9 1 0 0 1 1 1 1 Galactose binding lectin domain GPS PF01825.19 NM_001297705.1_1 - 1.4e-13 51.1 4.7 4.1e-13 49.6 4.7 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 NM_001297705.1_1 - 1e-08 35.2 1.2 3.1e-08 33.7 1.2 1.9 1 0 0 1 1 1 1 Hormone receptor domain DUF5074 PF16819.3 NM_001297705.1_1 - 1.4 8.9 6.4 0.92 9.4 1.2 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF5074) Latrophilin PF02354.14 NM_001297705.1_2 - 2.1e-101 339.6 6.6 2.9e-101 339.1 6.6 1.1 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region TNRC6-PABC_bdg PF16608.3 NM_015088.2_2 - 4.5e-109 364.5 27.0 4.5e-109 364.5 27.0 6.2 5 2 1 6 6 6 1 TNRC6-PABC binding domain RRM_occluded PF16842.3 NM_015088.2_2 - 0.00099 18.8 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_1 PF00076.20 NM_015088.2_2 - 0.0034 17.0 0.0 0.0079 15.9 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-H2C2_2 PF13465.4 NM_001080412.2_2 - 3e-24 84.2 83.1 4e-05 23.7 5.9 12.2 12 0 0 12 12 12 8 Zinc-finger double domain BTB PF00651.29 NM_001080412.2_2 - 9.1e-22 77.3 0.1 1.8e-21 76.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 NM_001080412.2_2 - 1.2e-14 53.7 78.0 0.00011 22.3 2.1 10.6 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001080412.2_2 - 1.1e-13 50.6 78.6 0.14 12.9 0.8 11.3 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001080412.2_2 - 3.6e-07 30.2 40.1 0.0016 18.6 0.0 9.0 9 0 0 9 9 9 3 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_001080412.2_2 - 4.8e-05 22.9 0.7 4.8e-05 22.9 0.7 5.8 6 0 0 6 6 6 2 zinc-finger C2H2-type zf-met PF12874.5 NM_001080412.2_2 - 0.00064 19.9 0.3 0.00064 19.9 0.3 7.7 7 0 0 7 7 7 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 NM_001080412.2_2 - 0.0014 18.4 54.9 0.43 10.5 1.0 9.7 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_8 PF15909.3 NM_001080412.2_2 - 0.002 18.3 1.7 0.002 18.3 1.7 5.0 3 2 2 5 5 5 1 C2H2-type zinc ribbon Casc1_N PF15927.3 NM_001319977.1_2 - 1.9e-54 184.2 6.4 1.9e-54 184.2 6.4 2.3 2 0 0 2 2 2 1 Cancer susceptibility candidate 1 N-terminus tRNA-synt_2b PF00587.23 NM_152334.2_2 - 2.5e-36 125.2 0.0 3.9e-36 124.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.18 NM_152334.2_2 - 8.5e-18 64.2 0.1 2.1e-17 62.9 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.19 NM_152334.2_2 - 4.1e-12 45.8 0.0 9.3e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.12 NM_152334.2_2 - 2.6e-11 43.3 0.1 5.2e-11 42.3 0.1 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain WCCH PF03716.12 NM_001282804.1_3 - 6.2 6.5 8.6 0.72 9.4 0.4 2.4 2 0 0 2 2 2 0 WCCH motif Kazal_2 PF07648.13 NM_016192.3_2 - 3e-15 56.0 22.0 3.7e-08 33.3 3.4 3.6 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 NM_016192.3_2 - 1.6e-08 34.3 40.0 6.1e-05 22.8 8.2 4.5 4 1 1 5 5 5 2 Kazal-type serine protease inhibitor domain Zona_pellucida PF00100.21 NM_001290104.1_1 - 1.7e-46 158.9 2.7 2.1e-46 158.6 0.6 2.1 2 0 0 2 2 2 1 Zona pellucida-like domain Gal-3-0_sulfotr PF06990.9 NM_001318114.1_1 - 5.1e-205 680.8 0.1 6.4e-205 680.5 0.1 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase MFS_1 PF07690.14 NM_001164277.1_2 - 2.3e-48 164.8 43.4 4.1e-46 157.4 25.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_001164277.1_2 - 0.0019 17.0 27.1 0.21 10.3 9.0 4.0 3 1 0 4 4 4 4 Sugar (and other) transporter Glyco_hydro_56 PF01630.16 NM_003549.3_1 - 2.7e-121 404.5 0.0 3.4e-121 404.2 0.0 1.1 1 0 0 1 1 1 1 Hyaluronidase EGF_2 PF07974.11 NM_003549.3_1 - 0.002 18.3 0.8 0.002 18.3 0.8 2.5 2 1 0 2 2 2 1 EGF-like domain EGF PF00008.25 NM_003549.3_1 - 0.19 11.9 4.7 1.2 9.3 4.7 2.4 1 1 0 1 1 1 0 EGF-like domain Peptidase_M29 PF02073.13 NM_003549.3_1 - 0.34 9.5 0.3 0.49 9.0 0.3 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) C2 PF00168.28 NM_001199096.1_1 - 1.8e-30 105.1 0.0 2.8e-14 53.1 0.0 3.9 3 1 0 3 3 3 2 C2 domain Membr_traf_MHD PF10540.7 NM_001199096.1_1 - 1.4e-15 57.7 3.4 6.7e-07 29.6 0.0 2.7 2 1 1 3 3 3 2 Munc13 (mammalian uncoordinated) homology domain SPRY PF00622.26 NM_001098624.2_2 - 3.7e-17 62.4 0.0 6.1e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_001098624.2_2 - 1.4e-12 46.9 0.2 1.5e-11 43.6 0.0 2.4 2 0 0 2 2 2 1 SPRY-associated domain zf-B_box PF00643.22 NM_001098624.2_2 - 4e-09 36.4 24.0 1.2e-08 34.8 0.8 4.1 3 0 0 3 3 3 2 B-box zinc finger fn3 PF00041.19 NM_001098624.2_2 - 8.2e-08 32.4 0.2 1.6e-07 31.4 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_UBOX PF13445.4 NM_001098624.2_2 - 3.9e-07 29.8 9.0 3.9e-07 29.8 9.0 3.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_001098624.2_2 - 3.1e-06 26.8 8.4 3.1e-06 26.8 8.4 3.7 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001098624.2_2 - 1.3e-05 24.9 11.7 1.3e-05 24.9 11.7 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_001098624.2_2 - 1.6e-05 24.8 12.0 1.6e-05 24.8 12.0 4.5 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 NM_001098624.2_2 - 0.0001 22.3 11.4 0.0001 22.3 11.4 4.0 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_001098624.2_2 - 0.00053 19.7 11.0 0.00053 19.7 11.0 4.3 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Pur_ac_phosph_N PF16656.3 NM_001098624.2_2 - 0.036 14.5 0.2 0.073 13.5 0.2 1.5 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Serine_rich PF08824.8 NM_001098624.2_2 - 1.1 9.1 4.3 3.1 7.6 4.3 1.7 1 1 0 1 1 1 0 Serine rich protein interaction domain Mtc PF03820.15 NM_001322983.1_2 - 2.8e-115 384.5 0.5 3.6e-115 384.2 0.5 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier zf-LITAF-like PF10601.7 NM_001199054.1_2 - 1.2e-21 76.6 13.9 1.2e-21 76.6 13.9 3.1 4 0 0 4 4 4 1 LITAF-like zinc ribbon domain Pkinase_Tyr PF07714.15 NM_004517.3_1 - 4.1e-38 131.0 0.0 6.2e-38 130.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.4 NM_004517.3_1 - 3.7e-23 81.1 1.3 2.7e-10 40.2 0.2 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_004517.3_1 - 6.7e-23 80.6 2.4 6.1e-10 39.3 0.1 4.0 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Pkinase PF00069.23 NM_004517.3_1 - 5.3e-22 78.3 0.0 8.5e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.5 NM_004517.3_1 - 1.7e-20 73.3 0.1 2e-10 41.0 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 NM_004517.3_1 - 8.5e-20 70.1 0.2 5.5e-06 26.5 0.1 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.4 NM_004517.3_1 - 4.6e-18 63.3 0.2 5.7e-06 26.2 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat CENP-P PF13096.4 NM_001286969.1_2 - 1.9e-85 284.9 0.2 2.9e-85 284.3 0.2 1.3 1 0 0 1 1 1 1 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P UCH PF00443.27 NM_015306.2_2 - 3.7e-46 157.6 0.2 7.4e-46 156.6 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_015306.2_2 - 1.5e-22 80.4 0.0 3.4e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.29 NM_015306.2_2 - 0.0043 16.8 0.0 0.011 15.6 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain ubiquitin PF00240.21 NM_015306.2_2 - 0.14 11.8 0.2 0.38 10.4 0.2 1.6 1 0 0 1 1 1 0 Ubiquitin family zf-C2H2_jaz PF12171.6 NM_001308223.1_3 - 0.0019 18.3 0.4 0.0044 17.2 0.4 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001308223.1_3 - 0.0038 17.4 0.3 0.0096 16.1 0.3 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Peptidase_M8 PF01457.14 NM_033029.3_2 - 4.4e-45 154.2 8.0 5.7e-32 111.0 0.0 3.9 2 1 1 3 3 3 3 Leishmanolysin Adaptin_N PF01602.18 NM_001127.3_2 - 2.7e-164 547.5 15.1 3.4e-164 547.1 15.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 NM_001127.3_2 - 1.7e-67 226.3 12.7 1.4e-65 220.1 1.4 3.5 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.8 NM_001127.3_2 - 8.2e-35 119.1 0.0 1.9e-34 118.0 0.0 1.7 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.4 NM_001127.3_2 - 9.2e-22 77.1 3.5 3.7e-08 33.5 0.0 5.9 3 2 4 7 7 7 6 HEAT repeats HEAT PF02985.20 NM_001127.3_2 - 7.8e-12 44.2 8.7 0.0096 16.0 0.1 7.0 7 0 0 7 7 7 3 HEAT repeat Alpha_adaptinC2 PF02883.18 NM_001127.3_2 - 3e-09 37.0 0.4 7.3e-09 35.8 0.4 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd3 PF12719.5 NM_001127.3_2 - 6.4e-09 35.3 4.5 1.8e-05 24.0 0.3 2.5 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain Arm PF00514.21 NM_001127.3_2 - 3e-06 26.9 4.4 0.019 14.9 0.0 5.1 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.7 NM_001127.3_2 - 0.00015 21.7 6.4 0.1 12.7 0.0 5.0 2 2 1 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.6 NM_001127.3_2 - 0.00022 20.7 1.6 0.95 8.9 0.1 4.0 2 2 0 2 2 2 2 CLASP N terminal Arm_2 PF04826.11 NM_001127.3_2 - 0.014 14.7 0.1 0.042 13.2 0.1 1.8 1 0 0 1 1 1 0 Armadillo-like Cohesin_HEAT PF12765.5 NM_001127.3_2 - 0.042 13.9 0.0 37 4.5 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion UNC45-central PF11701.6 NM_001127.3_2 - 0.055 13.3 0.5 2.4 7.9 0.0 3.0 3 1 0 3 3 3 0 Myosin-binding striated muscle assembly central HEAT_EZ PF13513.4 NM_001127.3_2 - 0.068 13.5 7.0 9.5 6.7 0.0 5.7 7 0 0 7 7 7 0 HEAT-like repeat Sec7_N PF12783.5 NM_001127.3_2 - 0.92 9.3 5.5 0.5 10.2 0.4 3.0 3 1 2 5 5 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Pkinase PF00069.23 NM_001276717.1_1 - 8.2e-67 225.2 0.0 1.1e-66 224.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001276717.1_1 - 4.2e-45 153.9 0.0 5.9e-45 153.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 NM_001276717.1_1 - 6.6e-16 58.3 0.1 1.5e-15 57.2 0.1 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 NM_001276717.1_1 - 1.8e-07 30.7 0.0 2.7e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001276717.1_1 - 0.056 12.7 0.1 0.091 12.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001276717.1_1 - 0.18 11.5 1.1 2.4 7.9 0.1 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF4211 PF13926.4 NM_001076786.2_3 - 2.5e-23 82.6 0.1 6.5e-23 81.3 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) PMI_typeI PF01238.19 NM_001289157.1_1 - 1.6e-128 428.9 0.0 3.5e-72 243.5 0.1 2.1 1 1 1 2 2 2 2 Phosphomannose isomerase type I FYVE PF01363.19 NM_024613.3_1 - 1.8e-17 63.1 7.3 1.8e-17 63.1 7.3 1.9 2 0 0 2 2 2 1 FYVE zinc finger PH PF00169.27 NM_024613.3_1 - 9.9e-10 38.7 0.1 1.9e-09 37.8 0.1 1.5 1 0 0 1 1 1 1 PH domain FYVE_2 PF02318.14 NM_024613.3_1 - 0.0041 17.2 4.3 0.0087 16.1 4.3 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger ATP1G1_PLM_MAT8 PF02038.14 NM_001136012.1_3 - 5.2e-20 70.4 3.1 5.6e-18 63.9 0.0 2.7 3 0 0 3 3 3 2 ATP1G1/PLM/MAT8 family ENTH PF01417.18 NM_144679.2_2 - 1.5e-06 28.1 0.0 2.5e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 ENTH domain M-inducer_phosp PF06617.11 NM_021872.3_2 - 1.1e-94 316.7 14.1 1.4e-81 273.7 7.9 2.3 1 1 1 2 2 2 2 M-phase inducer phosphatase Rhodanese PF00581.18 NM_021872.3_2 - 7.2e-11 42.4 0.0 1.5e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain BaffR-Tall_bind PF09256.8 NM_052945.3_3 - 2.1e-16 59.2 9.4 3.8e-16 58.4 9.4 1.4 1 0 0 1 1 1 1 BAFF-R, TALL-1 binding DUF4079 PF13301.4 NM_052945.3_3 - 0.1 12.6 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) SKG6 PF08693.8 NM_052945.3_3 - 0.11 11.7 1.4 0.21 10.9 1.4 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Hydrolase_4 PF12146.6 NM_032859.2_2 - 7.4e-14 51.4 0.0 1.4e-08 34.2 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 NM_032859.2_2 - 1.9e-12 47.2 0.0 1.3e-07 31.4 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.10 NM_032859.2_2 - 3.1e-06 26.0 0.0 0.00088 17.9 0.0 2.5 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.5 NM_032859.2_2 - 0.0002 21.9 0.0 0.00042 20.9 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 NM_032859.2_2 - 0.0065 16.2 0.0 0.044 13.4 0.0 2.1 2 1 1 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.11 NM_032859.2_2 - 0.0078 15.9 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.11 NM_032859.2_2 - 0.026 14.0 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) BAAT_C PF08840.9 NM_032859.2_2 - 0.035 13.9 0.0 0.074 12.8 0.0 1.4 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.19 NM_032859.2_2 - 0.059 12.7 0.0 0.092 12.1 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family GalKase_gal_bdg PF10509.7 NM_001289031.1_3 - 1.1e-22 79.2 0.0 2e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.24 NM_001289031.1_3 - 2.1e-13 50.2 0.6 4.4e-13 49.1 0.6 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.11 NM_001289031.1_3 - 3.1e-10 40.2 0.0 7.2e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal ATP1G1_PLM_MAT8 PF02038.14 NM_001243598.2_2 - 1.3e-16 59.5 0.1 2.4e-16 58.7 0.1 1.3 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family LRR_8 PF13855.4 NM_022567.2_2 - 2.3e-48 161.7 10.6 3.4e-15 55.4 0.1 5.5 2 1 4 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 NM_022567.2_2 - 5.8e-17 61.3 9.1 9.3e-05 22.6 0.3 5.8 4 1 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_022567.2_2 - 5.3e-09 35.7 0.6 0.015 14.6 0.0 4.1 2 2 2 4 4 4 4 Leucine-rich repeat LRR_5 PF13306.4 NM_022567.2_2 - 1.4e-08 34.6 0.0 0.00028 20.7 0.0 2.2 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 NM_022567.2_2 - 9.2e-06 25.0 4.7 3.3e-05 23.3 4.7 2.1 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 NM_022567.2_2 - 0.0096 16.1 14.1 2.6 8.7 0.2 7.1 7 1 1 8 8 8 1 Leucine Rich Repeat ATP12 PF07542.9 NM_145691.3_1 - 2.4e-39 134.2 0.3 3.7e-39 133.6 0.3 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Pkinase PF00069.23 NM_001252043.1_2 - 4.5e-63 213.0 0.0 7.2e-63 212.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001252043.1_2 - 3.2e-43 147.8 0.0 5.3e-43 147.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SSXT PF05030.10 NM_001007559.2_1 - 8.2e-29 98.9 4.3 1.3e-28 98.3 4.3 1.3 1 0 0 1 1 1 1 SSXT protein (N-terminal region) Sarcoglycan_1 PF04790.11 NM_001322881.1_3 - 7.9e-47 159.7 0.1 6.3e-30 104.3 0.0 2.2 1 1 1 2 2 2 2 Sarcoglycan complex subunit protein DUF2345 PF10106.7 NM_001322881.1_3 - 0.0016 18.2 0.0 0.0026 17.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2345) MTS PF05175.12 NM_016173.4_1 - 5.1e-11 42.3 0.0 1.7e-10 40.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.4 NM_016173.4_1 - 8.2e-09 35.3 0.0 1.3e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_016173.4_1 - 1.1e-08 35.5 0.0 1.9e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.13 NM_016173.4_1 - 1.8e-05 24.3 0.0 2.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.11 NM_016173.4_1 - 3e-05 23.4 0.0 4.5e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.10 NM_016173.4_1 - 0.00039 21.0 0.0 0.00062 20.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.16 NM_016173.4_1 - 0.0014 18.2 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.10 NM_016173.4_1 - 0.0018 18.7 0.0 0.0032 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.8 NM_016173.4_1 - 0.0032 17.1 0.0 0.0053 16.4 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_4 PF02390.15 NM_016173.4_1 - 0.0039 16.5 0.0 0.006 15.9 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_16 PF10294.7 NM_016173.4_1 - 0.0053 16.4 0.0 0.0084 15.7 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_18 PF12847.5 NM_016173.4_1 - 0.029 14.2 0.0 0.048 13.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain N6_N4_Mtase PF01555.16 NM_016173.4_1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 DNA methylase Methyltransf_24 PF13578.4 NM_016173.4_1 - 0.15 13.0 0.0 0.32 11.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Tmemb_161AB PF10268.7 NM_001256766.1_2 - 6.5e-136 453.6 0.0 5.3e-100 335.2 0.2 2.0 1 1 1 2 2 2 2 Predicted transmembrane protein 161AB TPR_1 PF00515.26 NM_001286707.1_2 - 1 9.1 5.6 22 5.0 0.2 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat Peptidase_C48 PF02902.17 NM_001282803.1_2 - 1.2e-32 113.4 4.6 1.2e-32 113.4 4.6 1.7 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain TMEM215 PF15746.3 NM_001282803.1_2 - 1.2 8.4 4.0 2.9 7.1 4.0 1.6 1 0 0 1 1 1 0 TMEM215 family Spectrin PF00435.19 NM_001145127.1_1 - 6.1 7.2 23.1 0.075 13.4 4.3 2.8 2 1 0 2 2 2 0 Spectrin repeat DUF3915 PF13054.4 NM_001291911.1_1 - 0.097 12.5 5.0 0.16 11.8 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) 7tm_1 PF00001.19 NM_001291911.1_3 - 1.5e-29 102.9 31.6 3e-28 98.7 28.3 3.1 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001291911.1_3 - 7.9e-10 38.4 17.9 7.9e-10 38.4 17.9 2.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_001291911.1_3 - 7.5e-05 22.5 15.7 0.00022 20.9 12.9 2.3 1 1 0 2 2 2 1 Olfactory receptor PX PF00787.22 NM_001012994.1_2 - 3.9e-22 78.3 1.6 7.1e-22 77.4 1.6 1.4 1 0 0 1 1 1 1 PX domain Vps5 PF09325.8 NM_001012994.1_2 - 2.3e-06 27.2 0.6 0.00062 19.2 0.6 2.2 1 1 0 1 1 1 1 Vps5 C terminal like BAR PF03114.16 NM_001012994.1_2 - 1.3e-05 24.9 0.3 1.9e-05 24.3 0.3 1.2 1 0 0 1 1 1 1 BAR domain SAM_1 PF00536.28 NM_001204067.1_1 - 3.5e-35 120.1 0.1 3.4e-16 59.3 0.1 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001204067.1_1 - 2.1e-28 98.1 0.4 4.5e-15 55.4 0.1 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.21 NM_001204067.1_1 - 4.8e-20 71.9 0.7 4.8e-20 71.9 0.7 1.8 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 NM_001204067.1_1 - 0.00017 21.6 0.1 0.00031 20.8 0.1 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Coq4 PF05019.11 NM_001204067.1_1 - 0.012 14.8 0.1 0.053 12.7 0.1 1.8 1 1 0 1 1 1 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Peptidase_A22B PF04258.11 NM_178581.2_2 - 1.4e-101 339.6 8.8 1.9e-101 339.2 8.8 1.1 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.9 NM_178581.2_2 - 5.2e-05 22.7 6.5 9.4e-05 21.9 6.5 1.4 1 0 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease DUF4345 PF14248.4 NM_178581.2_2 - 0.0028 17.4 0.8 0.0028 17.4 0.8 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4345) Presenilin PF01080.15 NM_178581.2_2 - 0.012 14.3 5.7 0.014 14.0 4.8 1.6 1 1 0 1 1 1 0 Presenilin UCH PF00443.27 NM_001290325.1_1 - 1.6e-41 142.4 1.8 2e-41 142.1 0.5 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001290325.1_1 - 4.1e-25 88.9 0.3 3.3e-24 85.9 0.3 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-AN1 PF01428.14 NM_021943.2_2 - 4.5e-08 33.0 7.9 2.4e-07 30.7 7.9 2.4 1 0 0 1 1 1 1 AN1-like Zinc finger zf-A20 PF01754.14 NM_021943.2_2 - 2.6e-05 23.9 6.5 8.8e-05 22.2 6.5 2.0 1 0 0 1 1 1 1 A20-like zinc finger Collagen PF01391.16 NM_001318753.1_1 - 1.1e-47 159.4 162.2 1.3e-09 37.6 20.5 6.2 2 2 4 6 6 6 6 Collagen triple helix repeat (20 copies) MBT PF02820.16 NM_015478.6_2 - 1e-94 310.7 1.6 9.3e-33 112.3 0.2 3.4 3 0 0 3 3 3 3 mbt repeat zf-C2HC PF01530.16 NM_015478.6_2 - 1.5e-14 53.7 10.2 1.5e-14 53.7 10.2 2.5 2 0 0 2 2 2 1 Zinc finger, C2HC type PMG PF05287.10 NM_001077711.1_3 - 3.7e-52 176.8 42.9 5.3e-52 176.3 42.9 1.1 1 0 0 1 1 1 1 PMG protein Cortexin PF11057.6 NM_206833.3_2 - 3e-39 132.6 0.0 4.4e-39 132.1 0.0 1.2 1 0 0 1 1 1 1 Cortexin of kidney CART PF06373.9 NM_004291.3_3 - 2e-38 130.3 4.0 3e-38 129.7 4.0 1.3 1 0 0 1 1 1 1 Cocaine and amphetamine regulated transcript protein (CART) Spore_Cse60 PF10957.6 NM_004291.3_3 - 0.041 13.7 0.0 0.071 13.0 0.0 1.3 1 0 0 1 1 1 0 Sporulation protein Cse60 DUF2114 PF09887.7 NM_004291.3_3 - 0.067 11.6 0.0 0.086 11.2 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2114) Claudin_2 PF13903.4 NM_001204212.1_1 - 1.4e-24 86.8 6.6 1.1e-14 54.5 1.7 2.3 1 1 1 2 2 2 2 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 NM_001204212.1_1 - 0.00024 20.9 12.0 0.0048 16.7 0.2 2.9 2 1 1 3 3 3 2 PMP-22/EMP/MP20/Claudin family CoA_transf_3 PF02515.15 NM_001167595.1_1 - 3.7e-81 273.0 0.0 5.8e-81 272.3 0.0 1.3 1 0 0 1 1 1 1 CoA-transferase family III Ank_2 PF12796.5 NM_001199562.1_2 - 1.8e-40 137.3 15.3 1.1e-09 38.6 0.2 4.6 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001199562.1_2 - 1.4e-34 117.9 1.0 1.8e-07 31.5 0.1 6.5 5 1 1 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.28 NM_001199562.1_2 - 6.1e-32 108.5 5.6 1.6e-05 25.0 0.0 7.4 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.4 NM_001199562.1_2 - 1.6e-29 101.4 7.4 2.7e-11 43.4 1.3 6.4 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001199562.1_2 - 2.6e-26 88.6 6.0 0.00016 21.7 0.0 7.5 6 1 0 6 6 6 5 Ankyrin repeat Patatin PF01734.20 NM_001199562.1_2 - 3.6e-16 59.8 5.2 3.1e-15 56.8 5.2 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase RRM_1 PF00076.20 NM_001286626.1_3 - 1.3e-17 63.2 0.0 2e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 NM_001286626.1_3 - 0.0013 18.7 0.0 0.0031 17.4 0.0 1.6 1 0 0 1 1 1 1 Limkain b1 RRM_7 PF16367.3 NM_001286626.1_3 - 0.0015 18.4 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Macoilin PF09726.7 NM_001286626.1_3 - 0.0095 14.4 20.6 0.016 13.6 20.6 1.3 1 0 0 1 1 1 1 Transmembrane protein Nup35_RRM_2 PF14605.4 NM_001286626.1_3 - 0.012 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 NM_001286626.1_3 - 0.015 14.8 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 NM_001286626.1_3 - 0.015 15.2 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif RRM_occluded PF16842.3 NM_001286626.1_3 - 0.033 13.9 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif LAP1C PF05609.10 NM_001286626.1_3 - 3.4 6.5 15.2 5 6.0 15.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PI3K_1B_p101 PF10486.7 NM_001286626.1_3 - 7.5 4.0 18.3 10 3.6 18.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit bZIP_1 PF00170.19 NM_194071.3_1 - 1.3e-13 50.7 16.8 2e-13 50.1 16.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_194071.3_1 - 3.7e-08 33.2 10.1 3.7e-08 33.2 10.1 1.8 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_194071.3_1 - 1.4e-05 25.4 10.2 2.4e-05 24.6 10.2 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor JMY PF15871.3 NM_194071.3_1 - 0.8 8.8 6.4 1.2 8.2 6.4 1.1 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein HAUS-augmin3 PF14932.4 NM_194071.3_1 - 0.86 8.9 6.1 1.3 8.4 6.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 APG6 PF04111.10 NM_194071.3_1 - 3 7.0 6.5 4.6 6.4 6.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Fox-1_C PF12414.6 NM_001082575.2_1 - 1.1e-39 134.4 20.6 2.6e-39 133.3 20.6 1.7 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 NM_001082575.2_1 - 2.7e-18 65.4 0.1 2.7e-18 65.4 0.1 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001082575.2_1 - 0.061 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_M14 PF00246.22 NM_001323574.1_3 - 7.1e-24 85.0 0.0 2.5e-23 83.2 0.0 1.8 1 1 0 1 1 1 1 Zinc carboxypeptidase DUF4700 PF15771.3 NM_178173.3_1 - 0 1043.4 18.6 0 1043.2 18.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4700) ATG16 PF08614.9 NM_178173.3_1 - 0.037 14.1 7.8 0.094 12.8 7.8 1.6 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.10 NM_178173.3_1 - 0.71 9.7 5.8 0.6 10.0 3.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.8 NM_178173.3_1 - 3.2 7.8 10.5 4.4 7.3 8.3 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SlyX PF04102.10 NM_178173.3_1 - 4.4 7.9 12.8 1.1 9.7 2.6 3.1 1 1 2 3 3 3 0 SlyX PH PF00169.27 NM_001040118.2_1 - 4.6e-46 155.5 0.2 3.3e-13 49.9 0.0 5.4 5 0 0 5 5 5 4 PH domain RhoGAP PF00620.25 NM_001040118.2_1 - 8.7e-46 155.4 0.0 1.5e-45 154.6 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain ArfGap PF01412.16 NM_001040118.2_1 - 4.5e-31 107.2 0.0 1.1e-30 105.9 0.0 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf RA PF00788.21 NM_001040118.2_1 - 1.2e-12 48.1 0.0 3e-12 46.9 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH_11 PF15413.4 NM_001040118.2_1 - 6.2e-12 45.7 4.0 0.24 11.7 0.0 6.8 5 2 1 6 6 6 4 Pleckstrin homology domain SAM_1 PF00536.28 NM_001040118.2_1 - 1e-10 41.7 0.1 3e-10 40.3 0.1 1.8 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001040118.2_1 - 2.9e-10 40.0 0.0 8.6e-10 38.5 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.4 NM_001040118.2_1 - 1.9e-07 31.1 0.5 0.029 14.5 0.2 4.6 4 0 0 4 4 4 1 Pleckstrin homology domain PH_6 PF15406.4 NM_001040118.2_1 - 2.5e-07 30.8 0.0 0.0043 17.2 0.1 3.4 3 0 0 3 3 3 2 Pleckstrin homology domain PH_2 PF08458.8 NM_001040118.2_1 - 3.1e-05 24.2 0.0 0.75 10.0 0.0 3.6 3 0 0 3 3 3 2 Plant pleckstrin homology-like region PH_13 PF16652.3 NM_001040118.2_1 - 0.00076 19.2 0.0 0.91 9.3 0.1 3.5 4 0 0 4 4 4 1 Pleckstrin homology domain PH_9 PF15410.4 NM_001040118.2_1 - 0.071 13.3 0.1 0.79 10.0 0.0 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain Ig_2 PF13895.4 NM_001184872.1_3 - 2.4e-08 34.1 0.0 3.7e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_001184872.1_3 - 6.9e-05 23.3 0.0 0.00014 22.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 NM_001184872.1_3 - 0.00028 20.9 0.0 0.00049 20.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Methyltransf_16 PF10294.7 NM_001302704.1_2 - 6.1e-11 42.2 0.0 9.1e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase LST1 PF05083.11 NM_205839.2_1 - 1.3e-42 143.9 0.1 1.8e-42 143.3 0.1 1.2 1 0 0 1 1 1 1 LST-1 protein Herpes_gE PF02480.14 NM_205839.2_1 - 0.044 12.4 0.0 0.058 12.0 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E VanW PF04294.11 NM_205839.2_3 - 0.0065 16.0 0.1 0.0098 15.4 0.1 1.2 1 0 0 1 1 1 1 VanW like protein WD40 PF00400.30 NM_181308.2_1 - 2.3e-11 43.9 2.9 0.0003 21.4 0.2 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_181308.2_1 - 1.4e-06 28.4 0.0 0.82 9.9 0.0 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.10 NM_181308.2_1 - 0.00044 20.0 0.2 1.2 9.0 0.0 3.1 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.3 NM_181308.2_1 - 0.039 12.8 0.0 0.1 11.4 0.0 1.6 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.9 NM_181308.2_1 - 0.052 13.3 0.0 0.33 10.7 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A P53 PF00870.16 NM_001114980.1_1 - 5.9e-110 365.3 0.5 1.1e-109 364.4 0.5 1.5 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 NM_001114980.1_1 - 2e-18 65.3 0.2 4.6e-18 64.1 0.2 1.7 1 0 0 1 1 1 1 P53 tetramerisation motif SAM_2 PF07647.15 NM_001114980.1_1 - 7.5e-10 38.7 0.0 1.4e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Forkhead_N PF08430.10 NM_001114980.1_1 - 3.7 8.0 25.8 1.4 9.4 4.2 2.3 2 0 0 2 2 2 0 Forkhead N-terminal region zf-H2C2_2 PF13465.4 NM_021217.2_3 - 5.5e-83 269.8 146.6 1.6e-09 37.6 3.3 16.1 17 0 0 17 17 17 13 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_021217.2_3 - 5.3e-44 144.9 141.5 0.00025 21.5 6.0 15.4 15 0 0 15 15 15 12 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_021217.2_3 - 8.1e-44 145.6 143.2 3.4e-07 30.2 0.7 15.6 16 0 0 16 16 16 12 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_021217.2_3 - 5.6e-24 83.5 116.6 3.8e-05 23.4 0.4 14.6 14 1 0 14 14 14 11 C2H2-type zinc finger KRAB PF01352.25 NM_021217.2_3 - 8.2e-23 79.7 0.1 1.3e-22 79.0 0.1 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_021217.2_3 - 2e-08 34.1 96.0 0.0083 16.1 2.1 10.1 6 5 4 10 10 10 9 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_021217.2_3 - 3.1e-06 27.2 84.1 0.14 12.4 2.5 12.8 13 0 0 13 13 13 7 Zinc-finger double-stranded RNA-binding HTH_18 PF12833.5 NM_021217.2_3 - 0.25 11.5 12.5 54 4.0 0.1 6.9 7 1 1 8 8 8 0 Helix-turn-helix domain zf-C2HE PF16278.3 NM_021217.2_3 - 0.3 11.4 0.1 0.3 11.4 0.1 12.1 3 1 7 10 10 10 0 C2HE / C2H2 / C2HC zinc-binding finger R3H PF01424.20 NM_001318758.1_1 - 7.9e-21 73.7 0.1 1.4e-20 72.9 0.1 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.15 NM_001318758.1_1 - 3.2e-14 52.5 227.5 1.2e-05 25.2 14.0 13.3 14 1 0 14 14 14 8 NF-X1 type zinc finger CP2 PF04516.13 NM_198173.2_3 - 3.2e-78 262.1 0.0 4.7e-78 261.5 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor Sugar_tr PF00083.22 NM_001145099.1_3 - 5.7e-74 249.5 11.0 1.8e-55 188.5 0.7 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 NM_001145099.1_3 - 7.7e-21 74.3 33.7 6.9e-20 71.1 23.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.5 NM_001145099.1_3 - 0.027 13.2 0.4 0.047 12.4 0.0 1.5 2 0 0 2 2 2 0 MFS_1 like family PFK PF00365.18 NM_001002021.2_2 - 1.9e-196 650.6 5.7 1.7e-100 335.8 1.1 2.1 2 0 0 2 2 2 2 Phosphofructokinase PAW PF04721.15 NM_018297.3_1 - 3.1e-76 255.5 2.5 5.6e-76 254.6 2.5 1.4 1 0 0 1 1 1 1 PNGase C-terminal domain, mannose-binding module PAW PUB PF09409.8 NM_018297.3_1 - 5.7e-24 83.7 0.0 2.1e-23 81.9 0.0 2.0 2 0 0 2 2 2 1 PUB domain Transglut_core PF01841.17 NM_018297.3_1 - 9.9e-16 58.1 0.6 2.1e-15 57.0 0.6 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Rad4 PF03835.13 NM_018297.3_1 - 6.6e-11 41.9 0.5 1.3e-10 40.9 0.5 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain NGF PF00243.16 NM_001143808.1_2 - 2.6e-47 159.6 2.3 5.3e-47 158.6 2.3 1.5 1 0 0 1 1 1 1 Nerve growth factor family Med20 PF08612.9 NM_004275.4_1 - 1.7e-47 161.5 0.0 2.3e-47 161.1 0.0 1.1 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Gelsolin PF00626.20 NM_001127664.1_3 - 7.8e-109 355.6 0.0 7.4e-20 70.5 0.0 6.2 6 0 0 6 6 6 6 Gelsolin repeat E1-E2_ATPase PF00122.18 NM_174955.2_3 - 7.5e-65 218.2 1.2 7.5e-65 218.2 1.2 2.2 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 NM_174955.2_3 - 3.8e-46 156.9 4.5 7.2e-46 156.0 4.5 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 NM_174955.2_3 - 1.3e-20 73.2 0.1 2.1e-20 72.5 0.1 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 NM_174955.2_3 - 9.5e-20 71.7 0.2 1.2e-18 68.0 0.2 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 NM_174955.2_3 - 4.2e-18 64.6 0.9 7.5e-18 63.8 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 NM_174955.2_3 - 3.2e-06 27.0 1.1 3.2e-06 27.0 1.1 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 NM_174955.2_3 - 0.00096 19.5 0.1 0.003 17.9 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3106 PF11304.6 NM_174955.2_3 - 0.022 15.1 0.0 0.16 12.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) zf-H2C2_2 PF13465.4 NM_003442.5_3 - 4.5e-36 121.6 48.9 5.3e-08 32.8 0.6 7.7 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_003442.5_3 - 3.4e-28 96.3 47.4 4.2e-06 26.8 1.3 7.7 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_003442.5_3 - 5.3e-18 64.0 43.8 0.0039 17.8 0.6 7.9 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_8 PF15909.3 NM_003442.5_3 - 5.2e-06 26.5 16.6 0.029 14.5 4.7 3.5 1 1 2 3 3 3 3 C2H2-type zinc ribbon CopK PF11525.6 NM_003442.5_3 - 3.8e-05 23.1 1.5 2.6 7.6 0.0 4.8 4 1 1 5 5 5 2 Copper resistance protein K zf-C2H2_aberr PF17017.3 NM_003442.5_3 - 0.00081 19.4 23.3 0.18 11.8 0.4 5.9 3 1 3 6 6 6 4 Aberrant zinc-finger zf-C2H2_jaz PF12171.6 NM_003442.5_3 - 0.0049 17.0 18.5 3.6 7.9 0.4 6.7 7 0 0 7 7 7 2 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.16 NM_003442.5_3 - 0.023 15.3 0.8 0.023 15.3 0.8 3.6 2 1 1 3 3 3 0 TRAF-type zinc finger zf-C2H2_6 PF13912.4 NM_003442.5_3 - 0.027 14.3 0.6 0.027 14.3 0.6 5.4 5 0 0 5 5 5 0 C2H2-type zinc finger FOXP-CC PF16159.3 NM_003442.5_3 - 0.3 11.6 14.7 0.47 11.0 0.9 5.5 4 2 3 7 7 7 0 FOXP coiled-coil domain TNF PF00229.16 NM_172089.3_1 - 1.5e-19 70.0 0.3 1.3e-11 44.4 0.0 2.2 1 1 1 2 2 2 2 TNF(Tumour Necrosis Factor) family C1q PF00386.19 NM_172089.3_1 - 0.0043 17.1 0.0 0.11 12.6 0.0 2.1 2 0 0 2 2 2 1 C1q domain DUF2611 PF11022.6 NM_172089.3_1 - 0.022 15.0 0.0 8.1 6.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2611) ABM PF03992.14 NM_031232.3_2 - 3.7e-10 39.6 0.4 9.3e-10 38.4 0.4 1.7 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase EF-hand_5 PF13202.4 NM_031232.3_2 - 2.5e-07 29.8 3.4 9.8e-07 27.9 1.3 2.3 1 1 1 2 2 2 1 EF hand EF-hand_1 PF00036.30 NM_031232.3_2 - 1.4e-06 27.3 2.0 6.5e-06 25.2 1.0 2.2 1 1 1 2 2 2 1 EF hand EF-hand_7 PF13499.4 NM_031232.3_2 - 2.2e-05 24.7 1.2 0.00034 20.9 0.3 2.3 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_031232.3_2 - 6.3e-05 22.5 2.0 0.00036 20.1 2.0 2.2 1 1 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.4 NM_031232.3_2 - 0.00026 20.6 0.6 0.00067 19.3 0.4 1.7 1 1 0 1 1 1 1 EF-hand domain pair Cactin_mid PF10312.7 NM_031232.3_2 - 0.12 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Conserved mid region of cactin DivIC PF04977.13 NM_031232.3_2 - 0.19 11.4 0.2 0.41 10.3 0.0 1.6 2 0 0 2 2 2 0 Septum formation initiator FGE-sulfatase PF03781.14 NM_015411.2_2 - 2.4e-85 286.1 5.7 3e-85 285.8 5.7 1.1 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 OST3_OST6 PF04756.11 NM_001267818.1_3 - 6.2e-08 32.2 0.3 8.9e-08 31.7 0.3 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family GOLGA2L5 PF15070.4 NM_001282468.1_1 - 5.4e-09 35.1 0.0 7.7e-09 34.6 0.0 1.0 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 GOLGA2L5 PF15070.4 NM_001282468.1_3 - 5.5e-48 163.9 62.2 1.6e-27 96.3 27.0 4.2 3 1 1 4 4 4 3 Putative golgin subfamily A member 2-like protein 5 APG6 PF04111.10 NM_001282468.1_3 - 4.1 6.6 58.0 0.038 13.3 10.9 3.3 3 0 0 3 3 3 0 Autophagy protein Apg6 Golgin_A5 PF09787.7 NM_001282468.1_3 - 9 5.5 68.8 0.1 11.9 18.9 3.2 2 1 1 3 3 3 0 Golgin subfamily A member 5 DUF572 PF04502.11 NM_001320564.1_1 - 8.6e-99 331.1 3.0 1.2e-98 330.6 3.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) ZZ PF00569.15 NM_001320564.1_1 - 1.3 8.8 3.9 6.7 6.5 0.3 2.4 2 0 0 2 2 2 0 Zinc finger, ZZ type DUF1580 PF07618.9 NM_001320564.1_3 - 0.048 13.1 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) Opiods_neuropep PF01160.16 NM_001190900.1_1 - 3.4e-16 58.9 6.5 7.6e-16 57.8 6.5 1.6 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide DiSB-ORF2_chro PF16506.3 NM_001190900.1_3 - 0.02 14.8 0.1 0.044 13.6 0.1 1.5 1 0 0 1 1 1 0 Putative virion glycoprotein of insect viruses TRAPP PF04051.14 NM_001270892.1_3 - 1.9e-26 92.4 0.0 2.7e-26 91.9 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component zf-CXXC PF02008.18 NM_001317211.1_3 - 6.1e-07 29.2 24.2 6.1e-07 29.2 24.2 3.0 3 0 0 3 3 3 1 CXXC zinc finger domain Spindle_Spc25 PF08234.10 NM_020675.3_3 - 2.9e-21 75.3 0.2 6.7e-21 74.1 0.2 1.7 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Spc7 PF08317.9 NM_020675.3_3 - 0.00019 20.3 11.0 0.00028 19.8 11.0 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF3584 PF12128.6 NM_020675.3_3 - 0.0011 16.5 5.8 0.0014 16.1 5.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) SKA2 PF16740.3 NM_020675.3_3 - 0.017 14.8 5.8 0.031 13.9 5.8 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DUF4407 PF14362.4 NM_020675.3_3 - 0.034 13.4 7.6 0.054 12.7 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.7 NM_020675.3_3 - 0.064 12.2 9.7 0.095 11.6 9.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.13 NM_020675.3_3 - 0.35 10.2 3.5 0.49 9.8 3.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit IncA PF04156.12 NM_020675.3_3 - 0.51 10.0 9.0 0.83 9.3 9.0 1.3 1 0 0 1 1 1 0 IncA protein DUF342 PF03961.11 NM_020675.3_3 - 0.62 8.5 10.7 0.97 7.8 10.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) ORF6N PF10543.7 NM_020675.3_3 - 1.9 8.6 5.1 8.8 6.5 0.3 2.9 1 1 1 3 3 3 0 ORF6N domain Tubulin PF00091.23 NM_001303114.1_2 - 7.2e-69 231.8 0.0 1e-68 231.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_001303114.1_2 - 5.5e-51 171.9 0.0 9.1e-51 171.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 NM_001303114.1_2 - 0.0018 17.9 0.0 0.0034 16.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain CD99L2 PF12301.6 NM_134446.3_1 - 1e-68 230.7 0.2 1.4e-68 230.3 0.2 1.2 1 0 0 1 1 1 1 CD99 antigen like protein 2 ACT_7 PF13840.4 NM_134446.3_1 - 0.25 11.0 0.3 0.48 10.1 0.3 1.3 1 0 0 1 1 1 0 ACT domain EPO_TPO PF00758.16 NM_001290022.1_1 - 9e-43 145.9 0.1 2.1e-42 144.7 0.0 1.6 1 1 1 2 2 2 1 Erythropoietin/thrombopoietin DSPc PF00782.18 NM_001320478.1_3 - 1e-30 106.2 0.0 1.4e-30 105.7 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 NM_001320478.1_3 - 3.3e-05 23.9 0.0 5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 NM_001320478.1_3 - 0.00058 19.4 0.0 0.00081 18.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Tropomyosin_1 PF12718.5 NM_130384.2_2 - 0.012 15.6 18.7 0.023 14.7 18.7 1.3 1 0 0 1 1 1 0 Tropomyosin like HMMR_N PF15905.3 NM_130384.2_2 - 0.068 12.5 14.8 0.11 11.8 14.8 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Golgin_A5 PF09787.7 NM_130384.2_2 - 0.56 9.5 14.0 0.9 8.8 14.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 IncA PF04156.12 NM_130384.2_2 - 0.6 9.7 11.4 1.4 8.5 11.4 1.6 1 0 0 1 1 1 0 IncA protein DUF641 PF04859.10 NM_130384.2_2 - 0.74 10.0 13.7 0.46 10.7 6.7 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) PKcGMP_CC PF16808.3 NM_130384.2_2 - 0.8 9.5 7.7 0.086 12.6 0.5 2.5 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HIP1_clath_bdg PF16515.3 NM_130384.2_2 - 1 9.9 18.2 0.81 10.2 12.0 2.4 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Med21 PF11221.6 NM_130384.2_2 - 2.1 8.5 9.6 4.2 7.5 8.4 2.1 2 1 0 2 2 2 0 Subunit 21 of Mediator complex DUF342 PF03961.11 NM_130384.2_2 - 2.4 6.5 6.9 3.5 6.0 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) OmpH PF03938.12 NM_130384.2_2 - 3.9 7.3 16.0 6.5 6.6 16.0 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) FAM76 PF16046.3 NM_130384.2_2 - 7.9 5.6 9.4 14 4.8 9.4 1.4 1 0 0 1 1 1 0 FAM76 protein APG6 PF04111.10 NM_130384.2_2 - 10 5.3 11.0 16 4.6 11.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Lep_receptor_Ig PF06328.9 NM_175767.2_2 - 4.1e-30 103.5 0.6 1.1e-29 102.1 0.6 1.8 1 0 0 1 1 1 1 Ig-like C2-type domain fn3 PF00041.19 NM_175767.2_2 - 1e-12 48.1 0.1 4.4e-12 46.1 0.3 2.0 2 0 0 2 2 2 1 Fibronectin type III domain IL6Ra-bind PF09240.8 NM_175767.2_2 - 1.7e-06 28.2 0.3 3.2e-06 27.3 0.3 1.5 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.8 NM_175767.2_2 - 3.1e-06 27.2 0.2 6.7e-06 26.1 0.2 1.5 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding Pur_ac_phosph_N PF16656.3 NM_175767.2_2 - 0.017 15.5 0.1 0.017 15.5 0.1 1.7 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain fn3 PF00041.19 NM_175767.2_3 - 2.3e-14 53.4 1.6 4.6e-08 33.2 0.1 3.3 3 0 0 3 3 3 2 Fibronectin type III domain fn3_2 PF16893.3 NM_175767.2_3 - 0.023 14.7 0.0 0.059 13.4 0.0 1.6 2 0 0 2 2 2 0 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_175767.2_3 - 2 8.9 5.6 0.89 10.0 0.7 2.7 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain HEPN PF05168.12 NM_001278055.1_1 - 4.1e-09 36.4 0.1 1.4e-08 34.8 0.1 2.0 1 0 0 1 1 1 1 HEPN domain DnaJ PF00226.29 NM_001278055.1_1 - 0.00072 19.5 0.4 0.002 18.1 0.4 1.7 1 0 0 1 1 1 1 DnaJ domain HATPase_c_3 PF13589.4 NM_001278055.1_1 - 0.0019 17.9 0.1 16 5.2 0.0 4.7 3 2 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4368 PF14287.4 NM_001278055.1_1 - 0.039 14.1 0.3 0.37 11.0 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4368) ThaI PF15514.4 NM_001278055.1_1 - 0.12 11.8 0.0 1 8.8 0.0 2.2 2 0 0 2 2 2 0 Restriction endonuclease ThaI DUF3770 PF12603.6 NM_001278055.1_1 - 1.3 8.4 3.6 2.7 7.3 3.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3770) ubiquitin PF00240.21 NM_001278055.1_2 - 0.0057 16.2 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family IL6Ra-bind PF09240.8 NM_000206.2_3 - 2.4e-12 47.0 3.3 3.7e-12 46.4 3.3 1.3 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.8 NM_000206.2_3 - 3.9e-06 26.9 1.2 7e-06 26.1 1.2 1.3 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 NM_000206.2_3 - 9.3e-06 25.8 0.9 4.6e-05 23.5 0.1 2.2 2 0 0 2 2 2 1 Fibronectin type III domain PTB PF08416.11 NM_001319952.1_3 - 9.5e-39 132.4 0.1 1.4e-38 131.8 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SH3_1 PF00018.26 NM_001319952.1_3 - 1.5e-11 43.6 0.0 4.6e-11 42.0 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 NM_001319952.1_3 - 1.2e-07 31.3 0.0 3.5e-07 29.8 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001319952.1_3 - 3.1e-06 26.6 0.0 5.4e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 NM_001319952.1_3 - 0.00043 20.4 0.1 0.00092 19.3 0.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain hSH3 PF14603.4 NM_001319952.1_3 - 0.012 16.0 0.0 0.029 14.8 0.0 1.6 1 0 0 1 1 1 0 Helically-extended SH3 domain Calsarcin PF05556.9 NM_021245.3_3 - 3.1e-102 341.1 0.0 3.7e-102 340.8 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) MCC-bdg_PDZ PF10506.7 NM_001321417.1_3 - 9.6e-32 108.7 26.0 6.6e-29 99.6 3.4 3.3 3 1 0 3 3 3 2 PDZ domain of MCC-2 bdg protein for Usher syndrome FlaC_arch PF05377.9 NM_001321417.1_3 - 0.016 15.5 5.7 0.72 10.2 1.0 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Mei5 PF10376.7 NM_001321417.1_3 - 0.064 13.0 7.8 0.2 11.4 0.4 2.4 2 0 0 2 2 2 0 Double-strand recombination repair protein CAGE1 PF15066.4 NM_001321417.1_3 - 0.2 10.2 3.6 4.1 5.8 0.3 2.3 2 0 0 2 2 2 0 Cancer-associated gene protein 1 family DASH_Dam1 PF08653.8 NM_001321417.1_3 - 0.25 11.1 1.0 1.7 8.4 0.0 2.7 3 0 0 3 3 3 0 DASH complex subunit Dam1 HALZ PF02183.16 NM_001321417.1_3 - 0.53 10.4 9.9 0.084 13.0 2.0 3.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper ETRAMP PF09716.8 NM_001301773.1_1 - 0.1 12.6 0.1 2 8.4 0.0 2.6 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Promethin PF16015.3 NM_001301773.1_3 - 1.3e-11 44.2 3.1 1.3e-11 44.2 3.1 2.1 2 0 0 2 2 2 1 Promethin CAF1 PF04857.18 NM_001301086.1_2 - 1.8e-11 43.7 0.9 8.7e-08 31.6 0.2 3.0 2 1 1 3 3 3 2 CAF1 family ribonuclease OAD_gamma PF04277.11 NM_001301086.1_3 - 5.9 7.4 6.2 11 6.6 6.2 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Homeobox PF00046.27 NM_001009812.1_2 - 1e-18 66.7 1.7 2e-18 65.8 1.7 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_001009812.1_2 - 0.066 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Homeobox KN domain CoA_transf_3 PF02515.15 NM_001193313.1_1 - 3.9e-122 407.8 0.0 4.7e-122 407.5 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III Glyco_hydro_30C PF17189.2 NM_001193313.1_1 - 0.15 12.2 0.0 2.2 8.4 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 30 beta sandwich domain Ras PF00071.20 NM_006908.4_2 - 6.4e-54 181.8 0.0 8.3e-54 181.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_006908.4_2 - 7.6e-22 77.7 0.0 1.1e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_006908.4_2 - 9.2e-07 28.3 0.0 1.4e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family CDC27 PF09507.8 NM_006591.2_1 - 2.7e-126 422.3 28.2 3.3e-126 422.0 28.2 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 MLANA PF14991.4 NM_006591.2_1 - 0.8 9.9 3.1 3 8.0 3.1 2.0 1 0 0 1 1 1 0 Protein melan-A zf-H2C2_2 PF13465.4 NM_001324157.1_1 - 1.2e-113 366.8 129.5 5.1e-09 36.0 0.3 20.1 20 0 0 20 20 19 18 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001324157.1_1 - 1.2e-96 311.9 119.3 2.4e-06 27.5 0.3 18.4 17 0 0 17 17 17 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001324157.1_1 - 1.5e-46 152.8 111.8 0.0058 17.2 0.3 18.4 17 0 0 17 17 17 17 C2H2-type zinc finger KRAB PF01352.25 NM_001324157.1_1 - 3.7e-23 80.8 0.3 7.5e-23 79.8 0.3 1.6 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001324157.1_1 - 9.9e-20 70.3 75.3 0.00053 19.9 1.5 10.9 8 3 3 11 11 11 9 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001324157.1_1 - 4.3e-15 55.1 95.9 0.0011 18.7 0.6 17.2 17 0 0 17 17 17 9 C2H2-type zinc finger ADK_lid PF05191.12 NM_001324157.1_1 - 1.9e-07 30.8 40.5 0.0024 17.7 0.3 9.0 7 2 0 7 7 7 5 Adenylate kinase, active site lid DUF3268 PF11672.6 NM_001324157.1_1 - 0.00011 22.3 57.8 0.15 12.3 0.9 9.0 3 1 8 13 13 13 8 zinc-finger-containing domain DZR PF12773.5 NM_001324157.1_1 - 0.00013 21.7 71.7 1.6e+04 -4.4 17.8 9.1 1 1 1 2 2 0 0 Double zinc ribbon C1_4 PF07975.10 NM_001324157.1_1 - 0.0017 18.4 79.4 0.38 10.9 1.3 11.8 6 3 5 12 12 12 7 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 NM_001324157.1_1 - 0.0029 18.2 74.4 0.43 11.2 1.3 9.9 2 1 8 11 11 11 7 zinc-ribbon family zf-trcl PF13451.4 NM_001324157.1_1 - 0.0062 16.3 71.8 2.4 8.0 0.2 14.9 15 2 0 15 15 15 3 Probable zinc-ribbon domain XPA_N PF01286.16 NM_001324157.1_1 - 0.13 12.2 65.3 6.3 6.8 0.0 15.7 17 0 0 17 17 17 0 XPA protein N-terminal BolA PF01722.16 NM_001324157.1_1 - 2 8.6 25.2 5 7.4 0.4 6.6 5 1 0 5 5 5 0 BolA-like protein zinc_ribbon_9 PF14369.4 NM_001324157.1_1 - 3 8.1 38.9 1.4 9.1 0.0 12.8 16 0 0 16 16 15 0 zinc-ribbon Ribosomal_L6 PF00347.21 NM_000661.4_3 - 4.6e-33 113.6 1.4 1.8e-15 57.2 0.3 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 DUF4658 PF15555.4 NM_001286400.1_1 - 8e-60 200.2 4.1 1.9e-59 199.0 4.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4658) Homeobox_KN PF05920.9 NM_173211.1_2 - 2.7e-17 62.3 0.9 5e-17 61.4 0.9 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 NM_173211.1_2 - 2.1e-07 30.5 1.2 4e-07 29.6 1.2 1.4 1 0 0 1 1 1 1 Homeobox domain Homez PF11569.6 NM_173211.1_2 - 0.12 11.7 0.5 0.24 10.7 0.2 1.6 1 1 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez zf-C2H2 PF00096.24 NM_174900.4_1 - 1.1e-14 53.9 17.4 0.00029 21.0 0.3 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_174900.4_1 - 1.2e-14 53.9 16.2 1.6e-05 25.0 0.2 4.4 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_174900.4_1 - 6.4e-10 38.9 15.7 0.076 13.8 0.2 5.0 4 0 0 4 4 4 4 C2H2-type zinc finger Transpos_assoc PF13963.4 NM_174900.4_1 - 0.015 15.7 0.5 3.4 8.2 0.0 2.6 2 0 0 2 2 2 0 Transposase-associated domain zf-TRAF PF02176.16 NM_174900.4_1 - 0.047 14.2 9.8 5.4 7.7 0.2 3.4 1 1 2 3 3 3 0 TRAF-type zinc finger zf-C2H2_jaz PF12171.6 NM_174900.4_1 - 0.12 12.6 2.1 7.3 6.9 0.1 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding KOW PF00467.27 NM_001130824.1_3 - 2.7e-29 100.0 14.6 1.6e-07 30.9 0.2 7.3 8 0 0 8 8 8 6 KOW motif Spt5-NGN PF03439.11 NM_001130824.1_3 - 4e-28 97.0 0.1 7.3e-28 96.2 0.1 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.6 NM_001130824.1_3 - 5.1e-14 52.9 6.6 5.1e-14 52.9 6.6 3.2 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal DUF3912 PF13051.4 NM_001130824.1_3 - 0.021 14.8 0.2 2.6 8.1 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3912) Ribonuc_P_40 PF08584.9 NM_001130824.1_3 - 0.089 11.9 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit CDC45 PF02724.12 NM_001130824.1_3 - 0.7 8.0 22.4 1.1 7.4 22.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Spore_coat_CotO PF14153.4 NM_001130824.1_3 - 4.2 7.1 14.8 10 5.9 14.8 1.6 1 0 0 1 1 1 0 Spore coat protein CotO MORN PF02493.18 NM_001306200.1_3 - 5.2e-12 44.8 16.1 0.003 17.2 0.3 5.4 5 0 0 5 5 5 4 MORN repeat MORN_2 PF07661.11 NM_001306200.1_3 - 0.7 10.2 0.0 0.7 10.2 0.0 2.7 3 0 0 3 3 3 0 MORN repeat variant Pkinase PF00069.23 NM_024776.3_1 - 9.4e-12 44.7 0.0 1.8e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_024776.3_1 - 9.8e-06 24.9 0.0 2.1e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase SH3_2 PF07653.15 NM_015347.4_3 - 5.3e-32 109.2 0.0 2.1e-10 40.0 0.0 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_9 PF14604.4 NM_015347.4_3 - 1.4e-27 95.2 3.1 1.2e-11 44.1 0.1 3.6 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 NM_015347.4_3 - 1.2e-14 53.4 0.0 3.4e-06 26.4 0.0 3.8 3 0 0 3 3 3 3 SH3 domain fn3 PF00041.19 NM_015347.4_3 - 1.8e-12 47.3 2.8 0.0014 18.8 0.2 4.1 3 1 0 3 3 3 3 Fibronectin type III domain NUDE_C PF04880.11 NM_001025579.2_3 - 6.9e-46 156.8 0.4 6.9e-46 156.8 0.4 2.8 3 0 0 3 3 3 1 NUDE protein, C-terminal conserved region TPR_MLP1_2 PF07926.10 NM_001025579.2_3 - 0.0022 17.9 6.2 0.0022 17.9 6.2 3.0 1 1 2 3 3 3 1 TPR/MLP1/MLP2-like protein PRKG1_interact PF15898.3 NM_001025579.2_3 - 0.025 15.4 21.5 0.033 15.0 8.2 2.4 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Golgin_A5 PF09787.7 NM_001025579.2_3 - 0.17 11.2 24.4 0.27 10.5 24.4 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF1664 PF07889.10 NM_001025579.2_3 - 0.3 10.9 7.4 0.14 12.0 4.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Rootletin PF15035.4 NM_001025579.2_3 - 0.52 10.2 30.8 0.95 9.4 12.2 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion HALZ PF02183.16 NM_001025579.2_3 - 0.53 10.4 12.2 0.08 13.0 3.0 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF2410 PF10307.7 NM_001025579.2_3 - 0.58 9.8 7.2 2.1 8.0 6.9 1.8 1 1 0 1 1 1 0 Hypothetical protein (DUF2410) ATG16 PF08614.9 NM_001025579.2_3 - 0.85 9.6 35.7 2 8.4 19.4 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Fzo_mitofusin PF04799.11 NM_001025579.2_3 - 6.6 6.1 12.4 0.51 9.7 5.0 2.2 1 1 1 2 2 2 0 fzo-like conserved region KxDL PF10241.7 NM_001025579.2_3 - 8.1 6.7 12.5 1.3 9.2 4.9 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein RhoGAP PF00620.25 NM_001256026.1_1 - 1.3e-46 158.1 0.0 2.7e-46 157.0 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain ATG16 PF08614.9 NM_001256026.1_1 - 0.00015 21.9 6.1 0.00025 21.1 6.1 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.5 NM_001256026.1_1 - 0.001 19.1 7.4 0.0016 18.4 7.4 1.2 1 0 0 1 1 1 1 Tropomyosin like PH PF00169.27 NM_001256026.1_1 - 0.0028 18.0 0.0 0.0067 16.8 0.0 1.5 1 0 0 1 1 1 1 PH domain IncA PF04156.12 NM_001256026.1_1 - 0.0049 16.5 2.1 0.01 15.5 2.1 1.5 1 0 0 1 1 1 1 IncA protein HAUS-augmin3 PF14932.4 NM_001256026.1_1 - 0.054 12.9 5.0 0.097 12.1 5.0 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 CALCOCO1 PF07888.9 NM_001256026.1_1 - 0.064 11.7 6.2 0.091 11.2 6.2 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like ADIP PF11559.6 NM_001256026.1_1 - 0.13 12.2 7.3 0.22 11.5 7.3 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding APG6 PF04111.10 NM_001256026.1_1 - 0.18 11.0 4.7 0.28 10.4 4.7 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 TPR_MLP1_2 PF07926.10 NM_001256026.1_1 - 1.1 9.2 10.8 1.8 8.5 10.8 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein OmpH PF03938.12 NM_001256026.1_1 - 5 7.0 5.5 8.3 6.3 5.5 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) CENP-Q PF13094.4 NM_001256026.1_1 - 6.7 6.8 11.0 14 5.7 11.0 1.5 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Jnk-SapK_ap_N PF09744.7 NM_001256026.1_1 - 7.1 6.7 12.5 13 5.8 12.5 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 zf-CCCH_3 PF15663.3 NM_001271675.1_3 - 1.9e-56 188.9 4.5 4.1e-56 187.8 4.5 1.6 1 0 0 1 1 1 1 Zinc-finger containing family CPSase_L_D2 PF02786.15 NM_001122633.2_2 - 2.3e-116 386.5 0.9 3.5e-84 281.4 0.1 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.20 NM_001122633.2_2 - 2.3e-43 146.9 0.0 6e-43 145.6 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.26 NM_001122633.2_2 - 6.2e-41 140.1 0.0 1.1e-40 139.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.17 NM_001122633.2_2 - 1.3e-38 132.0 0.7 2.6e-38 130.9 0.7 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.20 NM_001122633.2_2 - 9.4e-21 74.0 0.5 4.5e-11 42.5 0.1 2.3 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.20 NM_001122633.2_2 - 2.7e-20 72.2 0.0 1.8e-19 69.5 0.0 2.4 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.11 NM_001122633.2_2 - 3.3e-14 52.8 0.8 7.9e-07 28.7 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.4 NM_001122633.2_2 - 1.2e-11 43.8 0.0 2.6e-06 26.3 0.0 3.5 3 1 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.12 NM_001122633.2_2 - 2.6e-05 24.2 0.4 0.088 12.7 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.11 NM_001122633.2_2 - 0.12 12.0 0.0 0.32 10.6 0.0 1.8 1 0 0 1 1 1 0 Peptidase C26 Fumble PF03630.12 NM_001324191.1_3 - 1.6e-115 385.7 0.0 2e-115 385.4 0.0 1.1 1 0 0 1 1 1 1 Fumble IRK PF01007.18 NM_170742.2_2 - 3.1e-128 427.2 1.8 4.5e-128 426.7 1.8 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_170742.2_2 - 0.001 18.9 3.3 0.001 18.9 3.3 2.6 2 0 0 2 2 2 1 Ion channel PDZ PF00595.22 NM_003098.2_3 - 5e-18 65.1 0.7 7.9e-18 64.5 0.7 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PH PF00169.27 NM_003098.2_3 - 7e-12 45.7 0.0 5.4e-06 26.7 0.0 2.5 2 0 0 2 2 2 2 PH domain PDZ_2 PF13180.4 NM_003098.2_3 - 0.0036 17.4 0.1 0.0068 16.6 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Ldl_recept_a PF00057.16 NM_000527.4_2 - 1.3e-86 284.4 142.0 4e-14 52.4 11.8 8.6 8 1 0 8 8 8 7 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 NM_000527.4_2 - 1.7e-67 223.5 5.7 9.8e-14 51.4 0.1 5.7 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 NM_000527.4_2 - 2.3e-21 75.6 40.6 2.4e-09 37.2 2.0 5.6 3 1 1 4 4 4 3 Coagulation Factor Xa inhibitory site cEGF PF12662.5 NM_000527.4_2 - 5.7e-14 51.6 8.6 6.1e-06 25.9 0.7 4.9 3 0 0 3 3 3 3 Complement Clr-like EGF-like EGF_CA PF07645.13 NM_000527.4_2 - 1.3e-07 31.6 7.6 1.3e-07 31.6 7.6 9.7 7 2 0 7 7 7 2 Calcium-binding EGF domain SGL PF08450.10 NM_000527.4_2 - 4.7e-06 26.2 0.5 0.12 11.8 0.1 2.7 2 1 1 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region EGF PF00008.25 NM_000527.4_2 - 0.0024 18.0 20.1 0.0045 17.1 5.7 9.0 8 1 0 8 8 8 3 EGF-like domain PARP PF00644.18 NM_001323521.1_2 - 9.7e-13 48.1 0.2 1.8e-12 47.2 0.2 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PID_2 PF14719.4 NM_017933.4_3 - 4.7e-17 62.3 0.2 7.9e-17 61.6 0.2 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID PF00640.21 NM_017933.4_3 - 1.4e-05 25.0 0.2 2.3e-05 24.3 0.2 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) VCBS PF13517.4 NM_007059.3_3 - 0.00012 22.5 0.0 0.00073 19.9 0.0 2.2 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.21 NM_007059.3_3 - 0.00087 19.2 0.0 2.1 8.4 0.0 2.6 2 0 0 2 2 2 2 FG-GAP repeat AcetylCoA_hyd_C PF13336.4 NM_007059.3_3 - 0.11 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain BBS2_Mid PF14783.4 NM_007059.3_3 - 0.19 11.7 0.0 56 3.7 0.0 3.2 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Itfg2 PF15907.3 NM_007059.3_3 - 0.23 10.4 0.0 18 4.2 0.0 2.1 1 1 1 2 2 2 0 Integrin-alpha FG-GAP repeat-containing protein 2 TBPIP PF07106.11 NM_013290.6_2 - 2.9e-52 176.7 13.5 1.8e-51 174.1 13.5 1.9 1 1 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Mnd1 PF03962.13 NM_013290.6_2 - 1.7e-06 27.9 9.3 2.4e-06 27.4 9.3 1.2 1 0 0 1 1 1 1 Mnd1 family Penicillinase_R PF03965.14 NM_013290.6_2 - 8e-05 22.8 0.5 0.00014 22.1 0.5 1.3 1 0 0 1 1 1 1 Penicillinase repressor NPA PF16469.3 NM_013290.6_2 - 0.0032 18.0 6.3 0.0032 18.0 6.3 1.7 2 0 0 2 2 2 1 Nematode polyprotein allergen ABA-1 SKA2 PF16740.3 NM_013290.6_2 - 0.0033 17.0 2.8 0.0055 16.3 2.8 1.3 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 Snapin_Pallidin PF14712.4 NM_013290.6_2 - 0.045 14.1 0.6 0.092 13.1 0.6 1.5 1 0 0 1 1 1 0 Snapin/Pallidin Spc24 PF08286.9 NM_013290.6_2 - 0.06 13.4 1.9 0.4 10.8 1.9 2.0 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 FlxA PF14282.4 NM_013290.6_2 - 0.11 12.3 2.3 0.29 11.0 1.6 1.9 1 1 1 2 2 2 0 FlxA-like protein SlyX PF04102.10 NM_013290.6_2 - 0.18 12.4 1.2 1 9.9 1.2 2.2 1 1 0 1 1 1 0 SlyX DUF4407 PF14362.4 NM_013290.6_2 - 0.19 10.9 5.1 0.26 10.4 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ax_dynein_light PF10211.7 NM_013290.6_2 - 0.28 11.0 8.7 0.87 9.4 8.0 1.8 1 1 1 2 2 2 0 Axonemal dynein light chain Cnn_1N PF07989.9 NM_013290.6_2 - 0.67 10.0 3.7 1.4 9.0 2.9 1.8 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 IncA PF04156.12 NM_013290.6_2 - 0.94 9.1 5.5 1.7 8.3 5.5 1.4 1 0 0 1 1 1 0 IncA protein ZapB PF06005.10 NM_013290.6_2 - 2.4 8.5 5.8 11 6.4 5.8 2.1 1 1 0 1 1 1 0 Cell division protein ZapB Complex1_LYR PF05347.13 NM_001128302.2_3 - 1.1e-11 44.5 0.1 1.8e-11 43.7 0.1 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Synuclein PF01387.15 NM_001146055.1_2 - 4.9e-52 175.5 17.6 6.3e-52 175.2 17.6 1.1 1 0 0 1 1 1 1 Synuclein Porin_3 PF01459.20 NM_001184783.2_3 - 5e-83 278.5 1.4 6.1e-83 278.3 1.4 1.1 1 0 0 1 1 1 1 Eukaryotic porin Pkinase PF00069.23 NM_001164410.2_1 - 1.4e-52 178.6 0.0 1.6e-27 96.4 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001164410.2_1 - 4.9e-19 68.5 0.0 9.4e-12 44.6 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase RHINO PF15319.4 NM_001257097.1_2 - 9.1e-103 343.5 9.7 1.1e-102 343.2 9.7 1.1 1 0 0 1 1 1 1 RAD9, RAD1, HUS1-interacting nuclear orphan protein ARA70 PF12489.6 NM_001145262.1_2 - 3.8e-73 243.8 30.5 1.5e-46 157.7 4.7 5.9 3 1 2 5 5 5 4 Nuclear coactivator ANAPC4_WD40 PF12894.5 NM_001173466.1_2 - 1.6e-07 31.4 0.1 0.82 9.9 0.0 5.6 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 NM_001173466.1_2 - 1.2e-05 25.8 6.0 0.00021 21.9 0.1 4.3 5 0 0 5 5 5 1 WD domain, G-beta repeat PD40 PF07676.10 NM_001173466.1_2 - 0.00088 19.0 1.4 0.58 10.0 0.1 3.6 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat DUF4613 PF15390.4 NM_001173466.1_2 - 2.5 6.2 3.5 3.5 5.7 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4613) Arm PF00514.21 NM_001253854.1_1 - 5.2e-41 137.3 19.2 1.4e-09 37.5 0.0 8.9 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT PF02985.20 NM_001253854.1_1 - 1e-13 50.1 6.6 0.028 14.5 0.0 6.8 7 0 0 7 7 7 4 HEAT repeat HEAT_2 PF13646.4 NM_001253854.1_1 - 1.3e-11 44.6 9.7 0.0035 17.6 1.3 5.0 2 2 4 6 6 6 4 HEAT repeats Cnd1 PF12717.5 NM_001253854.1_1 - 1.5e-11 44.4 3.0 0.0036 17.2 0.2 4.6 2 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 NM_001253854.1_1 - 1.9e-09 37.7 14.3 0.002 18.4 0.0 5.9 5 1 0 5 5 5 3 HEAT-like repeat DNA_alkylation PF08713.9 NM_001253854.1_1 - 4.9e-08 32.8 0.2 2 8.0 0.0 4.4 2 1 1 4 4 4 3 DNA alkylation repair enzyme CHASE6_C PF17150.2 NM_001253854.1_1 - 2.6e-05 24.7 2.6 13 6.4 0.0 6.1 7 0 0 7 7 7 0 C-terminal domain of two-partite extracellular sensor domain Adaptin_N PF01602.18 NM_001253854.1_1 - 3.5e-05 22.4 7.8 0.013 13.9 3.5 3.4 1 1 2 3 3 3 3 Adaptin N terminal region Atx10homo_assoc PF09759.7 NM_001253854.1_1 - 5.9e-05 22.9 0.7 2.4 8.2 0.0 4.4 3 2 2 5 5 5 2 Spinocerebellar ataxia type 10 protein domain Proteasom_PSMB PF10508.7 NM_001253854.1_1 - 0.002 16.6 3.3 0.0064 14.9 0.8 2.4 1 1 0 2 2 2 1 Proteasome non-ATPase 26S subunit NopRA1 PF16201.3 NM_001253854.1_1 - 0.0079 15.6 0.1 1 8.8 0.0 3.4 4 1 0 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 RTP1_C1 PF10363.7 NM_001253854.1_1 - 0.077 13.0 1.0 0.2 11.7 0.3 2.1 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 V-ATPase_H_C PF11698.6 NM_001253854.1_1 - 0.15 12.1 2.3 4.6 7.3 0.2 3.5 3 1 1 4 4 4 0 V-ATPase subunit H HEAT_PBS PF03130.14 NM_001253854.1_1 - 0.53 11.0 12.1 0.66 10.7 0.1 4.7 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat TIG PF01833.22 NM_170724.2_1 - 1.3e-72 239.8 42.7 1.8e-09 37.4 0.1 14.9 13 1 1 14 14 14 10 IPT/TIG domain G8 PF10162.7 NM_170724.2_1 - 2.3e-52 176.1 0.0 4.6e-29 100.9 0.0 3.2 2 0 0 2 2 2 2 G8 domain Beta_helix PF13229.4 NM_170724.2_1 - 5.9e-19 68.3 7.0 1.3e-08 34.7 0.0 4.2 2 2 1 3 3 3 3 Right handed beta helix region NosD PF05048.11 NM_170724.2_1 - 1.5e-06 27.5 4.1 0.002 17.3 0.3 3.3 2 1 1 3 3 3 3 Periplasmic copper-binding protein (NosD) PA14 PF07691.10 NM_170724.2_1 - 0.0055 16.4 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 PA14 domain MISS PF15822.3 NM_144578.3_3 - 1.8e-119 397.8 123.4 1.8e-119 397.8 123.4 1.5 2 0 0 2 2 2 1 MAPK-interacting and spindle-stabilising protein-like G-patch PF01585.21 NM_018040.3_3 - 4.8e-15 55.1 3.4 7.4e-15 54.5 3.4 1.3 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 NM_018040.3_3 - 1.1e-07 31.7 0.7 3.2e-07 30.2 0.7 1.7 1 0 0 1 1 1 1 G-patch domain RNA_pol_3_Rpc31 PF11705.6 NM_001079843.2_2 - 0.0075 16.4 13.5 0.021 14.9 13.5 1.7 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Serpin PF00079.18 NM_001276490.1_2 - 1.7e-110 369.7 0.5 2.2e-110 369.4 0.5 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Transket_pyr PF02779.22 NM_001318975.1_2 - 7.9e-43 146.1 0.0 1.1e-42 145.6 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.18 NM_001318975.1_2 - 5.4e-35 119.8 0.0 8.6e-35 119.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, C-terminal domain TMEM189_B_dmain PF10520.7 NM_199203.2_3 - 1.8e-61 207.2 2.3 2.8e-61 206.6 2.3 1.2 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain UQ_con PF00179.24 NM_199203.2_3 - 9e-17 60.9 0.0 1.5e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme 7tm_4 PF13853.4 NM_001004752.1_1 - 1.7e-104 349.4 22.2 1.9e-104 349.2 22.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004752.1_1 - 2.7e-15 56.2 18.1 5.1e-15 55.3 18.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001004752.1_1 - 1.6e-05 24.3 9.2 1.6e-05 24.3 9.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PIH1 PF08190.10 NM_001169154.1_2 - 0.002 17.9 0.0 0.0026 17.5 0.0 1.2 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 FKBP_C PF00254.26 NM_001302959.1_1 - 2.8e-08 33.8 0.0 5.6e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.15 NM_001302959.1_1 - 1.7e-05 24.4 4.1 0.00097 19.0 0.4 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001302959.1_1 - 0.16 12.2 4.0 0.19 11.9 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001302959.1_1 - 1.3 8.6 6.4 7.5 6.2 0.0 3.1 3 0 0 3 3 3 0 TPR repeat Transket_pyr PF02779.22 NM_001145934.1_3 - 4.9e-37 127.2 0.1 1e-36 126.2 0.1 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.18 NM_001145934.1_3 - 2.7e-31 107.9 0.4 6.1e-31 106.7 0.4 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transketolase_N PF00456.19 NM_001145934.1_3 - 1.5e-23 83.2 0.0 2.7e-20 72.5 0.0 2.3 1 1 1 2 2 2 2 Transketolase, thiamine diphosphate binding domain E1_dh PF00676.18 NM_001145934.1_3 - 1.5e-06 27.3 0.0 2.3e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.4 NM_001145934.1_3 - 0.099 11.7 0.0 0.91 8.5 0.0 2.2 1 1 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase Y_phosphatase PF00102.25 NM_001145372.1_1 - 1.2e-79 267.0 0.3 1.2e-79 267.0 0.3 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PDZ PF00595.22 NM_001145372.1_1 - 2.3e-19 69.4 0.0 4.1e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FERM_C PF09380.8 NM_001145372.1_1 - 2e-14 53.6 4.2 5e-14 52.3 4.2 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain DSPc PF00782.18 NM_001145372.1_1 - 4.7e-06 26.3 0.0 8.5e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_001145372.1_1 - 0.00017 21.5 0.0 0.00036 20.4 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_001145372.1_1 - 0.0012 18.8 0.0 0.0026 17.8 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Aa_trans PF01490.16 NM_001308151.1_2 - 1e-32 113.2 10.7 1.3e-32 112.9 10.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein UQ_con PF00179.24 NM_181799.2_1 - 7.1e-08 32.1 0.1 0.0095 15.5 0.0 2.8 3 0 0 3 3 3 2 Ubiquitin-conjugating enzyme MITF_TFEB_C_3_N PF15951.3 NM_198177.2_2 - 1.5e-50 171.7 15.7 1.5e-50 171.7 15.7 2.0 2 0 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 NM_198177.2_2 - 6.7e-37 127.2 0.9 6.7e-37 127.2 0.9 3.0 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.24 NM_198177.2_2 - 2.3e-16 59.3 0.5 5e-16 58.3 0.5 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TFIIA PF03153.11 NM_198177.2_2 - 4.9 6.9 15.2 7.7 6.3 15.2 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit INT_SG_DDX_CT_C PF15300.4 NM_001291535.1_3 - 1e-25 89.1 1.8 1.6e-25 88.5 1.8 1.3 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus Mito_carr PF00153.25 NM_003355.2_3 - 2.3e-66 219.6 3.8 9.3e-25 86.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein SH2 PF00017.22 NM_005565.3_1 - 6.9e-14 51.5 0.1 1.4e-13 50.5 0.1 1.6 1 0 0 1 1 1 1 SH2 domain SAM_2 PF07647.15 NM_005565.3_1 - 7.6e-11 41.8 0.0 1.3e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_005565.3_1 - 0.098 13.0 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) ELP6 PF09807.7 NM_001031703.2_3 - 1.4e-117 391.4 0.1 1.7e-117 391.1 0.1 1.1 1 0 0 1 1 1 1 Elongation complex protein 6 CBM_21 PF03370.11 NM_001145115.2_1 - 5.6e-23 81.1 0.0 9.1e-23 80.4 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 NM_001145115.2_1 - 2.7e-06 27.7 0.0 6.2e-06 26.6 0.0 1.6 1 1 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Peptidase_C2 PF00648.19 NM_001198869.1_2 - 3.7e-130 433.1 0.0 4e-129 429.7 0.0 2.0 2 0 0 2 2 2 1 Calpain family cysteine protease Calpain_III PF01067.20 NM_001198869.1_2 - 3.2e-53 179.7 0.0 1.1e-52 178.0 0.0 1.9 2 0 0 2 2 2 1 Calpain large subunit, domain III EF-hand_8 PF13833.4 NM_001198869.1_2 - 5.1e-13 48.4 7.8 3.2e-10 39.5 0.1 4.0 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_001198869.1_2 - 1e-09 37.4 5.6 0.006 16.3 0.0 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.30 NM_001198869.1_2 - 1e-09 37.1 5.1 0.0084 15.5 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 NM_001198869.1_2 - 1.1e-07 32.0 5.1 0.041 14.2 0.1 3.9 3 2 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_001198869.1_2 - 0.49 9.9 7.9 3.1 7.3 0.0 4.1 4 0 0 4 4 4 0 EF hand SNAP-25 PF00835.17 NM_001322905.1_1 - 1.6e-20 73.0 0.2 3.1e-20 72.1 0.2 1.5 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.3 NM_001322905.1_1 - 1.4e-05 24.9 4.9 2e-05 24.4 4.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5089) V-SNARE_C PF12352.6 NM_001322905.1_1 - 0.73 10.0 5.5 0.32 11.2 0.7 2.7 2 1 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Exonuc_VII_L PF02601.13 NM_001322905.1_1 - 0.92 8.9 6.1 3.2 7.1 6.1 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit IncA PF04156.12 NM_001322905.1_1 - 0.96 9.1 3.5 0.53 9.9 0.4 1.9 2 0 0 2 2 2 0 IncA protein Spc7 PF08317.9 NM_001322905.1_1 - 2.8 6.6 9.1 0.33 9.6 2.4 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.4 NM_001322905.1_1 - 3.4 8.0 9.7 4.9 7.5 4.2 2.4 2 0 0 2 2 2 0 Snapin/Pallidin Alanine_zipper PF11839.6 NM_001322905.1_1 - 5.7 7.2 7.7 7.5 6.8 0.1 3.2 2 1 1 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein TRAPP PF04051.14 NM_001139444.2_1 - 4.4e-31 107.4 0.0 5.9e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Ldh_1_N PF00056.21 NM_001144071.1_1 - 4.5e-47 159.6 0.2 6.4e-47 159.1 0.2 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 NM_001144071.1_1 - 1e-22 80.7 0.0 1.5e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain UDPG_MGDP_dh_N PF03721.12 NM_001144071.1_1 - 0.0099 15.3 0.3 0.017 14.5 0.3 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glyco_hydro_4 PF02056.14 NM_001144071.1_1 - 0.014 14.8 2.2 0.47 9.8 0.1 2.2 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase ThiF PF00899.19 NM_001144071.1_1 - 0.13 11.5 0.1 0.21 10.8 0.1 1.2 1 0 0 1 1 1 0 ThiF family SH3_1 PF00018.26 NM_001190789.1_3 - 7.3e-27 92.6 0.0 4.9e-15 54.7 0.0 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 NM_001190789.1_3 - 5.3e-23 80.5 0.1 1.4e-12 47.1 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.15 NM_001190789.1_3 - 2.4e-19 68.6 0.2 1.6e-11 43.5 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain TPR_1 PF00515.26 NM_001190789.1_3 - 5.8e-12 44.8 1.6 1.3e-05 24.6 1.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001190789.1_3 - 2.4e-11 42.7 0.6 0.00022 21.0 0.6 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat PB1 PF00564.22 NM_001190789.1_3 - 3.7e-10 39.4 0.0 6.8e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 PB1 domain TPR_8 PF13181.4 NM_001190789.1_3 - 5.1e-10 38.6 0.9 0.0018 18.2 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001190789.1_3 - 9.8e-06 25.6 0.4 7e-05 22.9 0.2 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001190789.1_3 - 4.7e-05 23.8 0.1 0.18 12.4 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001190789.1_3 - 0.0046 16.7 0.1 5.2 7.0 0.1 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001190789.1_3 - 0.011 15.8 0.1 0.031 14.3 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001190789.1_3 - 0.053 13.8 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001190789.1_3 - 0.2 11.2 0.6 0.54 9.9 0.4 1.8 1 1 0 1 1 1 0 TPR repeat TPR_6 PF13174.4 NM_001190789.1_3 - 0.26 11.9 1.4 2.5 8.8 0.5 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat fn3 PF00041.19 NM_015986.3_2 - 0.00085 19.5 0.0 0.0016 18.6 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain YoaP PF14268.4 NM_015986.3_2 - 0.1 12.0 0.8 2.5 7.5 0.0 3.0 3 0 0 3 3 3 0 YoaP-like Methyltransf_11 PF08241.10 NM_001099677.1_2 - 0.029 14.9 0.0 0.053 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Ras PF00071.20 NM_001278667.1_1 - 1.8e-52 177.1 1.1 2.6e-52 176.6 1.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001278667.1_1 - 1.8e-31 108.7 0.3 2.9e-31 108.1 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001278667.1_1 - 3.4e-09 36.3 0.5 5.6e-09 35.6 0.5 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001278667.1_1 - 5.2e-05 23.2 0.0 8.4e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_001278667.1_1 - 0.0002 21.2 0.4 0.019 14.8 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_001278667.1_1 - 0.0012 18.2 0.1 0.0019 17.7 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 NM_001278667.1_1 - 0.028 13.6 0.1 0.043 13.0 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region HGTP_anticodon2 PF12745.5 NM_001278667.1_1 - 0.14 11.4 0.3 0.22 10.8 0.3 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs UCH PF00443.27 NM_001032730.1_2 - 7.6e-42 143.4 2.4 1e-41 143.0 2.4 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001032730.1_2 - 1.8e-21 76.9 1.1 1.8e-21 76.9 1.1 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase PseudoU_synth_1 PF01416.18 NM_001271985.1_2 - 2.4e-31 108.3 0.0 4e-31 107.6 0.0 1.4 1 0 0 1 1 1 1 tRNA pseudouridine synthase Shugoshin_N PF07558.9 NM_001012409.3_3 - 2.9e-11 42.9 2.2 7.4e-11 41.6 2.2 1.8 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.9 NM_001012409.3_3 - 6.3e-10 38.5 1.3 1.8e-09 37.1 1.3 1.8 1 0 0 1 1 1 1 Shugoshin C terminus Menin PF05053.11 NM_001012409.3_3 - 0.59 8.3 12.5 0.85 7.8 12.5 1.1 1 0 0 1 1 1 0 Menin DUF778 PF05608.10 NM_001012409.3_3 - 7.9 6.6 9.3 2.1 8.5 3.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF778) DUF1014 PF06244.10 NM_138442.3_3 - 7.7e-40 136.4 5.2 7.7e-40 136.4 5.2 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1014) HMG_box PF00505.17 NM_138442.3_3 - 0.00092 19.4 0.1 0.00092 19.4 0.1 2.1 2 1 0 2 2 2 1 HMG (high mobility group) box C1_1 PF00130.20 NM_017702.3_3 - 0.039 13.7 1.3 0.092 12.5 1.3 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Myb_DNA-binding PF00249.29 NM_021145.3_3 - 1.7e-28 98.4 12.2 4.1e-19 68.3 0.6 4.3 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 NM_021145.3_3 - 3.7e-16 59.0 4.1 9.3e-09 35.3 0.1 4.0 3 1 1 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.4 NM_021145.3_3 - 0.36 11.1 5.9 0.11 12.8 0.4 2.9 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain Med15 PF09606.8 NM_001293235.1_1 - 2.2e-179 598.7 128.5 2.8e-179 598.3 128.5 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal HipA_N PF07805.10 NM_001293235.1_1 - 0.52 10.8 2.4 45 4.6 3.2 2.7 2 0 0 2 2 2 0 HipA-like N-terminal domain SPATA6 PF14909.4 NM_001286238.1_3 - 3e-51 173.1 0.0 4.5e-51 172.5 0.0 1.3 1 0 0 1 1 1 1 Spermatogenesis-assoc protein 6 UQ_con PF00179.24 NM_182697.2_1 - 1.6e-15 56.8 0.2 3.1e-09 36.5 0.1 2.2 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme ADH_zinc_N PF00107.24 NM_001306171.1_3 - 5.7e-24 84.3 0.2 8.9e-24 83.7 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 NM_001306171.1_3 - 3e-21 75.2 0.1 4.9e-21 74.5 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 NM_001306171.1_3 - 0.0009 20.2 0.0 0.0018 19.2 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 NM_001306171.1_3 - 0.018 14.5 0.1 0.028 13.8 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glu_dehyd_C PF16912.3 NM_001306171.1_3 - 0.047 13.0 0.1 0.18 11.1 0.1 1.8 1 1 0 1 1 1 0 Glucose dehydrogenase C-terminus FCH PF00611.21 NM_001184975.1_2 - 5.4e-16 58.5 0.1 5.4e-16 58.5 0.1 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.4 NM_001184975.1_2 - 1.3e-14 53.7 0.1 2.6e-14 52.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001184975.1_2 - 3.2e-12 45.7 1.5 3.9e-12 45.4 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 NM_001184975.1_2 - 1.5e-06 27.7 0.0 4.1e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain GrpE PF01025.17 NM_001184975.1_2 - 0.0055 16.2 5.8 0.0055 16.2 5.8 1.8 1 1 1 2 2 2 1 GrpE DUF842 PF05811.11 NM_001184975.1_2 - 0.024 14.3 4.2 0.046 13.4 4.2 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) Tho2 PF11262.6 NM_001184975.1_2 - 0.41 9.6 5.6 0.62 9.1 5.6 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF3450 PF11932.6 NM_001184975.1_2 - 0.56 9.3 9.7 0.89 8.7 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Mnd1 PF03962.13 NM_001184975.1_2 - 1.8 8.2 9.2 3.2 7.4 9.2 1.4 1 0 0 1 1 1 0 Mnd1 family Atg14 PF10186.7 NM_001184975.1_2 - 2.8 6.8 11.0 4.2 6.2 11.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.11 NM_001184975.1_2 - 6.1 5.9 6.9 9.5 5.2 6.9 1.3 1 0 0 1 1 1 0 TMPIT-like protein Exonuc_VII_L PF02601.13 NM_001184975.1_2 - 6.3 6.1 7.0 9.1 5.6 7.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Methyltransf_25 PF13649.4 NM_001318856.1_3 - 4.2e-05 24.0 0.0 7.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001318856.1_3 - 0.00027 21.4 0.0 0.00048 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 NM_001318856.1_3 - 0.024 14.4 0.0 0.033 14.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain adh_short PF00106.23 NM_001256301.1_1 - 5.9e-44 149.7 0.0 8.2e-44 149.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_001256301.1_1 - 7.7e-35 120.4 0.0 1.1e-34 119.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_001256301.1_1 - 0.00043 20.1 0.0 0.00066 19.5 0.0 1.2 1 0 0 1 1 1 1 KR domain SHMT PF00464.17 NM_001281786.1_2 - 7e-22 77.4 0.0 9.3e-22 77.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase SHMT PF00464.17 NM_001281786.1_3 - 1.6e-158 527.4 0.0 2.1e-158 527.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.19 NM_001281786.1_3 - 0.0005 19.2 0.0 0.00073 18.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II MENTAL PF10457.7 NM_032016.3_1 - 2e-62 210.0 3.3 2.9e-62 209.5 3.3 1.2 1 0 0 1 1 1 1 Cholesterol-capturing domain zf-H2C2_2 PF13465.4 NM_001039891.2_3 - 4e-82 267.1 95.5 2.2e-08 34.0 0.6 15.0 15 0 0 15 15 15 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001039891.2_3 - 2.4e-61 200.8 96.8 1.3e-06 28.3 0.3 12.7 13 0 0 13 13 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001039891.2_3 - 1.5e-34 115.5 94.0 0.0022 18.5 3.1 13.3 14 0 0 14 14 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_001039891.2_3 - 1.6e-24 85.1 1.0 3.1e-24 84.3 1.0 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001039891.2_3 - 3.8e-11 42.5 69.1 0.17 11.7 0.3 12.7 12 0 0 12 12 12 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001039891.2_3 - 4.3e-09 36.2 51.9 0.023 14.7 2.9 7.5 5 1 2 8 8 8 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001039891.2_3 - 2.9e-05 24.1 59.0 0.68 10.2 0.4 11.2 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_001039891.2_3 - 0.069 13.4 32.3 0.91 9.8 0.9 6.1 4 1 2 7 7 7 0 zinc-finger-containing domain XPA_N PF01286.16 NM_001039891.2_3 - 0.11 12.4 43.6 5.6 7.0 0.1 11.0 11 0 0 11 11 11 0 XPA protein N-terminal C1_1 PF00130.20 NM_001039891.2_3 - 0.3 10.9 45.2 1.2 8.9 0.2 9.1 3 2 4 7 7 7 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.3 NM_001039891.2_3 - 0.36 11.5 50.2 1.1 9.9 1.2 7.5 4 2 5 9 9 9 0 zinc-ribbon family C1_4 PF07975.10 NM_001039891.2_3 - 0.91 9.7 47.4 0.51 10.5 2.7 8.1 2 2 5 9 9 9 0 TFIIH C1-like domain zf-LYAR PF08790.9 NM_001039891.2_3 - 5.3 6.9 38.2 2.2 8.2 0.3 9.5 10 0 0 10 10 10 0 LYAR-type C2HC zinc finger TspO_MBR PF03073.13 NM_001159726.1_1 - 1.7e-29 102.4 20.9 2.3e-29 102.1 20.9 1.1 1 0 0 1 1 1 1 TspO/MBR family CpcD PF01383.19 NM_001082533.1_1 - 0.085 13.0 0.2 0.18 12.0 0.2 1.4 1 0 0 1 1 1 0 CpcD/allophycocyanin linker domain Ribosomal_60s PF00428.17 NM_001082533.1_1 - 0.25 11.8 3.2 0.44 11.0 3.2 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Carb_anhydrase PF00194.19 NM_001082533.1_3 - 1.4e-65 221.2 0.1 2.2e-65 220.6 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase GCV_T PF01571.19 NM_001322118.1_1 - 8.1e-69 231.7 0.0 1.2e-68 231.2 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.22 NM_001322118.1_1 - 5.4e-41 141.2 0.0 8e-41 140.6 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T_C PF08669.9 NM_001322118.1_1 - 4.5e-21 74.8 0.0 8.7e-21 73.8 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain FAO_M PF16350.3 NM_001322118.1_1 - 2.9e-16 59.4 0.1 5.5e-16 58.5 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain HI0933_like PF03486.12 NM_001322118.1_1 - 0.047 12.3 0.0 0.073 11.6 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.12 NM_001322118.1_1 - 0.15 10.8 0.1 0.23 10.2 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Glyco_hydro_30 PF02055.14 NM_001171812.1_2 - 6.5e-179 594.2 0.1 8.8e-179 593.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.2 NM_001171812.1_2 - 8.3e-15 54.6 0.0 1.4e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Lipocalin PF00061.21 NM_002297.3_1 - 2.6e-27 95.7 0.0 3.1e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_4 PF13648.4 NM_002297.3_1 - 0.19 12.6 0.0 0.27 12.1 0.0 1.2 1 0 0 1 1 1 0 Lipocalin-like domain RNA_pol_A_bac PF01000.24 NM_203290.3_3 - 1.6e-30 105.6 0.0 2.5e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.22 NM_203290.3_3 - 9.7e-23 79.3 0.0 1.4e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DSPc PF00782.18 NM_001012644.2_1 - 1.7e-30 105.4 0.0 2.4e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 NM_001012644.2_1 - 5.4e-05 23.2 0.0 8e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 NM_001012644.2_1 - 0.00085 18.8 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Somatostatin PF03002.13 NM_199006.2_2 - 1.4e-09 37.6 5.9 2.8e-09 36.6 5.9 1.5 1 0 0 1 1 1 1 Somatostatin/Cortistatin family CENP-S PF15630.4 NM_199006.2_3 - 4.9e-18 65.2 0.2 8.1e-18 64.5 0.2 1.3 1 0 0 1 1 1 1 CENP-S protein FHA PF00498.24 NM_014110.4_3 - 5.7e-16 58.5 0.1 1.1e-15 57.5 0.1 1.5 1 0 0 1 1 1 1 FHA domain Macro PF01661.19 NM_017554.2_3 - 1.4e-63 212.1 0.4 4.7e-30 103.9 0.0 3.9 3 0 0 3 3 3 3 Macro domain PARP PF00644.18 NM_017554.2_3 - 7.3e-21 74.6 2.1 2.5e-20 72.9 2.1 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.18 NM_017554.2_3 - 0.00017 21.9 0.3 0.00081 19.8 0.3 2.2 1 0 0 1 1 1 1 WWE domain Syntaxin_2 PF14523.4 NM_017554.2_3 - 0.14 12.4 3.3 0.62 10.3 0.4 3.1 2 0 0 2 2 2 0 Syntaxin-like protein NID PF07292.11 NM_017554.2_3 - 0.74 10.4 7.2 66 4.1 0.0 5.2 6 0 0 6 6 6 0 Nmi/IFP 35 domain (NID) SRP19 PF01922.15 NM_001166393.1_2 - 0.34 11.7 2.0 0.98 10.3 2.0 1.8 1 0 0 1 1 1 0 SRP19 protein VHS PF00790.17 NM_001135732.1_3 - 1.5e-46 157.7 0.0 2.7e-46 156.8 0.0 1.4 1 0 0 1 1 1 1 VHS domain GAT PF03127.12 NM_001135732.1_3 - 1.7e-25 89.0 2.4 2.9e-25 88.2 2.4 1.4 1 0 0 1 1 1 1 GAT domain SRF-TF PF00319.16 NM_005920.3_1 - 6.1e-24 83.1 0.4 1.2e-23 82.2 0.4 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 NM_005920.3_1 - 1e-07 31.7 0.0 1e-07 31.7 0.0 2.8 2 1 0 2 2 2 1 Holliday junction regulator protein family C-terminal repeat DUF2360 PF10152.7 NM_005920.3_1 - 0.12 12.7 3.3 0.2 11.9 3.3 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) TFIIA PF03153.11 NM_005920.3_1 - 1.6 8.5 14.0 2.3 8.0 14.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.11 NM_005920.3_1 - 3.3 8.3 15.2 8.8 6.9 15.2 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Cyclin_C PF02984.17 NM_001136126.2_2 - 3.3e-17 62.5 0.0 4.8e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.8 NM_001136126.2_2 - 0.028 14.7 0.1 0.049 13.9 0.1 1.3 1 0 0 1 1 1 0 K cyclin, C terminal FOP_dimer PF09398.8 NM_144600.3_2 - 1.6e-16 60.2 0.2 2.6e-16 59.5 0.2 1.3 1 0 0 1 1 1 1 FOP N terminal dimerisation domain LisH_2 PF16045.3 NM_144600.3_2 - 3.8e-05 22.5 0.0 7.6e-05 21.5 0.0 1.6 1 0 0 1 1 1 1 LisH F420_oxidored PF03807.15 NM_001205316.1_2 - 8.7e-12 45.3 0.0 1.3e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.17 NM_001205316.1_2 - 0.00012 22.1 2.5 0.00031 20.8 0.7 2.3 1 1 1 2 2 2 1 Ferric reductase like transmembrane component IlvN PF07991.10 NM_001205316.1_2 - 0.0017 17.8 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.17 NM_001205316.1_2 - 0.0024 17.1 0.0 0.004 16.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.13 NM_001205316.1_2 - 0.0047 17.0 0.0 0.0069 16.4 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DUF1772 PF08592.9 NM_001205316.1_2 - 0.035 14.3 0.2 0.077 13.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) EF-hand_1 PF00036.30 NM_004066.2_1 - 9.6e-30 99.8 14.9 2.8e-08 32.6 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 NM_004066.2_1 - 3.8e-26 91.2 8.0 6.7e-13 48.8 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 NM_004066.2_1 - 1.8e-23 82.0 9.6 7.3e-12 44.7 1.6 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.4 NM_004066.2_1 - 2.7e-23 79.7 8.2 1.9e-08 33.5 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 NM_004066.2_1 - 3.6e-16 57.7 13.4 2.5e-05 23.5 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 NM_004066.2_1 - 1.5e-13 50.7 0.1 6.7e-06 26.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 NM_004066.2_1 - 4.1e-05 23.3 3.0 0.2 11.5 0.0 2.8 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.9 NM_004066.2_1 - 0.14 12.9 0.3 20 6.0 0.1 2.2 1 1 1 2 2 2 0 EF-hand domain DEAD PF00270.27 NM_006773.3_1 - 8.3e-45 152.6 0.0 1.5e-44 151.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_006773.3_1 - 9.2e-23 80.6 0.0 4.8e-22 78.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.4 NM_006773.3_1 - 6.4e-19 67.8 0.3 1.1e-18 67.0 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Swi5 PF07061.9 NM_001040011.1_1 - 1.2e-25 89.2 0.3 1.8e-25 88.7 0.3 1.2 1 0 0 1 1 1 1 Swi5 IncA PF04156.12 NM_001040011.1_1 - 0.14 11.8 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 IncA protein LRR_8 PF13855.4 NM_032777.9_3 - 1.2e-22 79.3 13.0 8.2e-14 51.0 6.4 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 NM_032777.9_3 - 1.3e-09 38.0 11.0 4.9e-05 23.5 1.5 3.5 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) 7tm_2 PF00002.22 NM_032777.9_3 - 1.9e-09 37.1 3.5 3.2e-09 36.3 3.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) LRR_1 PF00560.31 NM_032777.9_3 - 1.9e-05 24.3 9.5 0.12 12.8 0.2 5.4 4 0 0 4 4 4 2 Leucine Rich Repeat GPS PF01825.19 NM_032777.9_3 - 2.5e-05 24.7 0.1 8.9e-05 22.9 0.1 2.1 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 NM_032777.9_3 - 5.8e-05 23.2 0.4 0.0002 21.4 0.4 2.0 1 0 0 1 1 1 1 Hormone receptor domain Ig_3 PF13927.4 NM_032777.9_3 - 0.0017 18.8 0.0 0.0058 17.1 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_032777.9_3 - 0.0043 17.0 0.0 0.0085 16.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_032777.9_3 - 0.0052 16.8 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain TPKR_C2 PF16920.3 NM_032777.9_3 - 0.14 12.2 1.4 1.4 8.9 1.0 2.6 2 0 0 2 2 2 0 Tyrosine-protein kinase receptor C2 Ig-like domain KH_1 PF00013.27 NM_031262.3_1 - 2e-42 142.7 13.9 1.1e-19 69.8 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 NM_031262.3_1 - 3.1e-26 91.2 9.8 5.2e-26 90.5 9.8 1.4 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_2 PF07650.15 NM_031262.3_1 - 2.8e-13 49.4 5.9 0.0016 18.1 0.4 3.8 3 1 1 4 4 4 3 KH domain KH_4 PF13083.4 NM_031262.3_1 - 1.5e-07 31.1 5.7 1.3e-05 24.8 0.0 3.1 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 NM_031262.3_1 - 0.00024 21.0 3.1 0.62 10.1 0.2 3.5 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.3 NM_031262.3_1 - 0.1 12.5 0.0 3.1 7.7 0.0 2.4 2 0 0 2 2 2 0 KH-like RNA-binding domain DJ-1_PfpI PF01965.22 NM_031262.3_1 - 0.17 11.6 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family Raftlin PF15250.4 NM_015150.1_1 - 2e-230 765.3 0.1 6e-230 763.7 0.0 1.7 1 1 1 2 2 2 1 Raftlin DUF4177 PF13783.4 NM_015150.1_1 - 0.15 12.2 0.0 2.9 8.1 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4177) eIF3g PF12353.6 NM_139179.3_2 - 0.14 12.4 0.3 0.23 11.7 0.3 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G Lipase_3 PF01764.23 NM_139179.3_3 - 2.7e-18 66.1 0.0 4.5e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.18 NM_139179.3_3 - 0.0033 17.0 0.1 0.0091 15.5 0.0 1.7 2 0 0 2 2 2 1 Putative esterase Abhydrolase_6 PF12697.5 NM_139179.3_3 - 0.02 15.4 0.1 0.02 15.4 0.1 2.4 3 0 0 3 3 3 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 NM_139179.3_3 - 0.049 12.8 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.11 NM_139179.3_3 - 0.049 13.3 0.1 0.13 11.9 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold V-ATPase_H_N PF03224.12 NM_213620.2_1 - 9.2e-102 340.4 8.5 1.2e-101 340.0 6.0 2.1 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.6 NM_213620.2_1 - 2.6e-46 156.4 2.2 2.9e-46 156.2 0.3 2.1 2 0 0 2 2 2 1 V-ATPase subunit H Arm PF00514.21 NM_213620.2_1 - 4.1e-06 26.5 0.3 0.03 14.2 0.0 4.8 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Arm_2 PF04826.11 NM_213620.2_1 - 0.00088 18.7 0.1 0.0026 17.1 0.0 1.7 2 0 0 2 2 2 1 Armadillo-like HEAT_2 PF13646.4 NM_213620.2_1 - 0.0017 18.6 0.1 1.7 9.0 0.0 3.4 3 1 0 3 3 3 1 HEAT repeats DUF2326 PF10088.7 NM_213620.2_1 - 0.0062 16.1 0.1 0.015 14.9 0.1 1.6 1 0 0 1 1 1 1 Uncharacterised protein conserved in bacteria (DUF2326) HEAT PF02985.20 NM_213620.2_1 - 0.05 13.7 0.1 1.1 9.5 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat UCH PF00443.27 NM_213620.2_1 - 0.14 11.5 0.3 0.25 10.7 0.3 1.4 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase zf-H2C2_2 PF13465.4 NM_001144068.1_1 - 2.1e-60 198.5 62.9 1.8e-08 34.3 0.2 12.2 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001144068.1_1 - 3.1e-42 140.6 74.0 1.4e-06 28.3 0.3 11.3 11 0 0 11 11 11 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001144068.1_1 - 3.8e-23 80.0 68.5 0.0011 19.4 1.1 11.5 10 0 0 10 10 10 9 C2H2-type zinc finger KRAB PF01352.25 NM_001144068.1_1 - 1.6e-21 75.5 2.3 2.9e-21 74.7 2.3 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001144068.1_1 - 9.4e-08 32.1 41.4 1.1 9.5 0.0 9.8 9 0 0 9 9 9 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001144068.1_1 - 3.8e-06 26.6 53.5 0.012 15.4 2.5 9.6 9 0 0 9 9 9 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001144068.1_1 - 0.00026 20.9 43.2 0.019 14.9 2.5 6.8 4 2 4 8 8 7 5 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_001144068.1_1 - 0.91 10.2 33.4 2.2 8.9 0.9 6.0 3 1 3 7 7 7 0 zinc-ribbon family Rrp44_CSD1 PF17216.1 NM_001323940.1_2 - 1.8e-06 27.6 0.0 2.9e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Rrp44-like cold shock domain RNB PF00773.17 NM_001323940.1_3 - 5.2e-88 295.4 0.0 7.9e-88 294.8 0.0 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.1 NM_001323940.1_3 - 7.6e-07 28.9 0.0 3.4e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 S1 domain SCA7 PF08313.10 NM_020725.1_1 - 1.3e-27 95.3 2.6 2.9e-27 94.2 2.6 1.6 1 0 0 1 1 1 1 SCA7, zinc-binding domain DUF3505 PF12013.6 NM_020725.1_1 - 0.079 13.3 0.5 0.21 11.9 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3505) zf-H2C2_2 PF13465.4 NM_001165886.1_3 - 1.5e-157 505.5 135.4 4.4e-08 33.1 0.2 25.5 25 0 0 25 25 25 23 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001165886.1_3 - 7.4e-125 400.8 163.1 8.5e-07 29.0 2.4 24.8 24 0 0 24 24 24 24 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001165886.1_3 - 3.4e-68 220.2 161.1 0.0013 19.2 2.5 24.9 24 0 0 24 24 24 24 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001165886.1_3 - 2.4e-33 113.3 142.7 0.00043 20.0 0.2 24.4 24 0 0 24 24 24 16 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001165886.1_3 - 1.6e-19 69.6 104.4 0.011 15.7 1.6 13.6 7 3 5 14 14 14 13 Zinc ribbon domain C1_4 PF07975.10 NM_001165886.1_3 - 5.7e-09 36.0 105.1 0.05 13.7 2.5 15.0 6 4 10 16 16 16 6 TFIIH C1-like domain zf-C2H2_jaz PF12171.6 NM_001165886.1_3 - 9e-07 28.9 129.4 0.079 13.2 0.6 21.4 22 2 2 24 24 24 6 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 NM_001165886.1_3 - 1.1e-06 28.5 85.0 1.9 8.4 0.3 21.1 6 3 12 20 20 20 6 CpXC protein DUF3268 PF11672.6 NM_001165886.1_3 - 0.052 13.8 79.5 1.8 8.8 0.5 11.7 7 2 4 14 14 14 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 NM_001165886.1_3 - 0.28 11.8 104.3 0.84 10.3 1.5 12.4 1 1 14 17 17 17 0 zinc-ribbon family Metallophos PF00149.26 NM_001145399.1_2 - 5.7e-10 39.9 0.8 8.5e-10 39.3 0.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DSPc PF00782.18 NM_001319658.1_3 - 3.4e-12 46.2 0.0 4e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 NM_001319658.1_3 - 4.4e-10 39.8 0.0 6.8e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 NM_001319658.1_3 - 2.7e-06 27.0 0.0 3.8e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.11 NM_001319658.1_3 - 0.086 12.3 0.0 0.27 10.7 0.0 1.8 1 1 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase3 PF13350.4 NM_001319658.1_3 - 0.18 11.6 0.0 0.26 11.1 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Calc_CGRP_IAPP PF00214.17 NM_001253845.1_1 - 1.3e-05 25.5 0.6 2e-05 24.8 0.0 1.6 2 0 0 2 2 2 1 Calcitonin / CGRP / IAPP family NPC1_N PF16414.3 NM_001253845.1_2 - 0.11 11.9 2.5 0.18 11.2 2.5 1.2 1 0 0 1 1 1 0 Niemann-Pick C1 N terminus Pkinase PF00069.23 NM_144685.4_2 - 2.9e-49 167.7 0.0 5.8e-49 166.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_144685.4_2 - 5.4e-25 88.0 0.0 7.8e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_144685.4_2 - 0.00012 21.9 0.0 0.00035 20.4 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.12 NM_144685.4_2 - 0.025 13.8 0.2 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.9 NM_144685.4_2 - 0.028 13.3 0.1 0.042 12.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PX PF00787.22 NM_147777.3_2 - 2.4e-16 59.6 0.5 3.6e-16 59.0 0.5 1.3 1 0 0 1 1 1 1 PX domain MIT PF04212.16 NM_147777.3_2 - 0.002 18.0 0.0 0.0034 17.3 0.0 1.3 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Histone PF00125.22 NM_001161334.1_3 - 4.3e-24 85.3 0.4 6.7e-24 84.6 0.4 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_001161334.1_3 - 4.8e-06 26.6 0.0 1.1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 NM_001161334.1_3 - 0.016 15.6 0.0 0.035 14.5 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A YscO-like PF16789.3 NM_001161334.1_3 - 0.047 13.6 0.2 0.066 13.1 0.2 1.2 1 0 0 1 1 1 0 YscO-like protein ELO PF01151.16 NM_024090.2_3 - 4.8e-67 226.0 26.1 4.8e-67 226.0 26.1 1.5 2 0 0 2 2 2 1 GNS1/SUR4 family DER1 PF04511.13 NM_198440.3_2 - 6.5e-68 228.2 7.1 8.1e-68 227.9 7.1 1.1 1 0 0 1 1 1 1 Der1-like family Oleosin PF01277.15 NM_198440.3_2 - 0.23 11.1 3.5 0.078 12.6 0.3 1.8 1 1 1 2 2 2 0 Oleosin NTR PF01759.19 NM_181655.3_1 - 0.065 12.9 0.0 0.24 11.1 0.0 1.9 1 1 0 1 1 1 0 UNC-6/NTR/C345C module CybS PF05328.10 NM_001276504.1_1 - 2.4e-22 78.9 0.3 3.4e-22 78.4 0.3 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit SapB_2 PF03489.15 NM_198843.2_2 - 6.9e-20 70.7 12.9 1.7e-08 34.3 1.3 3.8 4 0 0 4 4 4 3 Saposin-like type B, region 2 SapA PF02199.13 NM_198843.2_2 - 4.2e-13 49.1 3.5 1.7e-12 47.1 3.5 2.1 1 0 0 1 1 1 1 Saposin A-type domain SapB_1 PF05184.13 NM_198843.2_2 - 1.2e-06 28.3 6.9 6.2e-06 26.0 2.3 3.4 3 1 0 3 3 3 1 Saposin-like type B, region 1 UDPGT PF00201.16 NM_001076.3_3 - 1.8e-264 878.0 0.7 2.2e-264 877.7 0.7 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 NM_001076.3_3 - 4e-06 26.8 0.0 7.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 NM_001076.3_3 - 0.024 14.5 0.0 0.12 12.2 0.0 2.0 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.4 NM_001076.3_3 - 0.033 14.1 0.0 2.5 8.0 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase 4-like Glyco_trans_4_4 PF13579.4 NM_001076.3_3 - 0.069 13.5 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain PMI_typeI PF01238.19 NM_001289155.1_1 - 1.2e-115 386.6 0.1 1.5e-115 386.2 0.1 1.1 1 0 0 1 1 1 1 Phosphomannose isomerase type I CCER1 PF15482.4 NM_152638.3_3 - 3.8e-120 399.4 25.4 5.4e-120 398.9 25.4 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing glutamate-rich protein family 1 Neugrin PF06413.9 NM_152638.3_3 - 0.02 14.8 7.6 0.029 14.3 7.6 1.1 1 0 0 1 1 1 0 Neugrin Nop14 PF04147.10 NM_152638.3_3 - 0.16 10.0 25.1 0.21 9.7 25.1 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.10 NM_152638.3_3 - 0.45 9.8 23.0 0.65 9.2 23.0 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.8 NM_152638.3_3 - 5.2 6.2 20.6 8.3 5.5 20.6 1.2 1 0 0 1 1 1 0 BUD22 7tm_1 PF00001.19 NM_001164377.1_1 - 8.3e-05 21.8 6.1 8.3e-05 21.8 6.1 2.6 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) GAPT PF11770.6 NM_001164377.1_1 - 0.15 11.8 0.3 0.23 11.1 0.3 1.3 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Serpin PF00079.18 NM_001235.3_2 - 9.9e-94 314.5 0.0 1.2e-93 314.3 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Gelsolin PF00626.20 NM_001320734.1_2 - 1.6e-58 194.4 0.0 1.1e-19 69.9 0.0 3.2 3 0 0 3 3 3 3 Gelsolin repeat LCE PF14672.4 NM_178429.3_3 - 1.5e-23 83.1 85.4 6e-21 74.7 37.8 3.6 2 1 1 3 3 3 2 Late cornified envelope CCDC23 PF15674.3 NM_199342.3_2 - 6.9e-35 118.7 11.6 1.2e-34 118.0 11.6 1.4 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 23 bZIP_1 PF00170.19 NM_001206486.2_2 - 2.7e-05 24.1 21.1 0.00031 20.6 13.3 2.3 2 0 0 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.13 NM_001206486.2_2 - 0.00013 21.8 19.8 0.00038 20.3 11.4 2.3 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001206486.2_2 - 0.0098 16.3 4.1 0.0098 16.3 4.1 2.3 2 0 0 2 2 2 1 bZIP Maf transcription factor HlyIII PF03006.18 NM_001272109.1_2 - 2.5e-17 63.2 0.5 4.1e-17 62.5 0.5 1.3 1 0 0 1 1 1 1 Haemolysin-III related HlyIII PF03006.18 NM_001272109.1_3 - 7.3e-14 51.9 4.3 1.1e-12 48.0 4.0 2.2 1 1 0 1 1 1 1 Haemolysin-III related zf-H2C2_2 PF13465.4 NM_006963.4_1 - 8.6e-33 111.2 43.5 3.5e-08 33.4 0.3 6.8 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_006963.4_1 - 3e-32 109.1 43.5 6.2e-07 29.4 0.4 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_006963.4_1 - 7e-17 60.5 41.8 0.0024 18.4 5.8 6.1 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_006963.4_1 - 9.2e-06 25.2 34.0 0.0057 16.3 5.0 5.6 5 0 0 5 5 5 3 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 NM_006963.4_1 - 0.00016 21.4 37.6 0.078 12.8 0.2 5.7 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_006963.4_1 - 0.0081 15.8 0.2 0.0081 15.8 0.2 6.6 5 2 0 5 5 5 3 C2H2-type zinc-finger domain ADK_lid PF05191.12 NM_006963.4_1 - 0.03 14.2 11.7 0.071 13.0 1.9 4.1 2 2 2 4 4 4 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 NM_006963.4_1 - 0.052 13.5 30.6 0.23 11.5 3.1 4.2 3 1 2 5 5 5 0 Zinc ribbon domain XPA_N PF01286.16 NM_006963.4_1 - 0.27 11.2 28.9 2.9 7.9 0.6 5.6 5 0 0 5 5 5 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_006963.4_1 - 0.5 11.0 23.5 0.8 10.4 3.2 3.6 1 1 3 4 4 4 0 zinc-ribbon family Prenyltransf PF01255.17 NM_138459.3_2 - 2.3e-08 33.7 0.0 1e-06 28.3 0.0 2.1 1 1 0 2 2 2 2 Putative undecaprenyl diphosphate synthase zf-RING_4 PF14570.4 NM_013316.3_2 - 6.5e-20 70.5 12.2 1.2e-19 69.6 12.2 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.4 NM_013316.3_2 - 1.8e-06 27.6 7.4 4.1e-06 26.4 7.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.20 NM_013316.3_2 - 1.5e-05 24.6 0.0 3.2e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4 PF00097.23 NM_013316.3_2 - 0.038 13.7 9.9 0.11 12.3 9.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.4 NM_013316.3_2 - 0.041 13.9 3.0 0.096 12.7 3.0 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-H2C2_2 PF13465.4 NM_182524.3_1 - 1.2e-132 426.8 142.7 4.4e-09 36.2 1.3 19.8 19 0 0 19 19 19 17 Zinc-finger double domain zf-C2H2 PF00096.24 NM_182524.3_1 - 3.9e-87 282.0 124.9 2.3e-06 27.6 0.4 19.2 19 0 0 19 19 18 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_182524.3_1 - 3.9e-43 142.2 117.8 0.0081 16.8 1.4 18.9 18 0 0 18 18 18 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_182524.3_1 - 1.2e-42 143.0 105.4 8.8e-05 22.2 0.6 19.0 18 0 0 18 18 18 16 C2H2-type zinc finger KRAB PF01352.25 NM_182524.3_1 - 1.6e-26 91.5 0.1 3.1e-26 90.6 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_11 PF16622.3 NM_182524.3_1 - 2.2e-24 84.8 63.1 0.0032 17.1 0.1 17.8 19 0 0 19 19 18 10 zinc-finger C2H2-type XPA_N PF01286.16 NM_182524.3_1 - 1.2e-22 79.5 80.6 0.97 9.4 0.1 17.7 18 0 0 18 18 17 13 XPA protein N-terminal Zn-ribbon_8 PF09723.8 NM_182524.3_1 - 4e-18 65.1 106.1 0.0023 17.9 2.9 13.3 5 3 13 18 18 17 13 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_182524.3_1 - 2.1e-17 62.8 76.6 0.35 11.1 0.0 17.5 18 0 0 18 18 17 7 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 NM_182524.3_1 - 2.1e-11 43.4 85.6 0.0026 17.5 2.7 16.0 14 4 0 14 14 13 4 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 NM_182524.3_1 - 3.9e-09 37.0 85.1 0.33 11.6 1.4 9.5 4 1 2 9 9 9 8 zinc-ribbon family FAM178 PF14816.4 NM_182524.3_1 - 9e-06 24.8 9.0 6.8 5.4 0.2 7.4 1 1 8 9 9 9 1 Family of unknown function, FAM178 ADK_lid PF05191.12 NM_182524.3_1 - 4.6e-05 23.2 62.2 1.6 8.7 1.5 11.2 3 2 8 11 11 11 6 Adenylate kinase, active site lid C1_4 PF07975.10 NM_182524.3_1 - 0.019 15.1 88.2 0.16 12.1 1.8 13.4 2 1 15 18 18 18 0 TFIIH C1-like domain MRP-S23 PF10484.7 NM_182524.3_1 - 0.041 14.0 0.0 2.2e+02 1.9 0.0 5.5 3 2 2 6 6 6 0 Mitochondrial ribosomal protein S23 zf-RING_7 PF02591.13 NM_182524.3_1 - 0.066 13.3 74.4 6.6 6.9 0.1 17.0 18 0 0 18 18 18 0 C4-type zinc ribbon domain DUF3268 PF11672.6 NM_182524.3_1 - 0.12 12.6 62.4 2.1 8.6 1.1 9.5 2 1 7 12 12 12 0 zinc-finger-containing domain zf-AN1 PF01428.14 NM_182524.3_1 - 0.14 12.2 94.6 12 6.0 1.5 18.5 15 2 3 18 18 18 0 AN1-like Zinc finger PknG_rubred PF16919.3 NM_182524.3_1 - 0.17 11.9 55.4 0.34 10.9 0.4 9.2 1 1 8 10 10 10 0 Protein kinase G rubredoxin domain GAGA PF09237.9 NM_182524.3_1 - 0.95 9.2 23.7 0.3 10.8 0.1 7.2 6 3 4 10 10 10 0 GAGA factor YhfH PF14149.4 NM_182524.3_1 - 8.1 6.4 84.0 16 5.4 0.3 17.2 17 0 0 17 17 17 0 YhfH-like protein DUF2431 PF10354.7 NM_138378.2_2 - 3e-38 131.5 0.0 4.5e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) FDX-ACB PF03147.12 NM_138378.2_2 - 1.4e-15 57.3 0.1 2.5e-15 56.5 0.1 1.4 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Methyltransf_4 PF02390.15 NM_138378.2_2 - 0.17 11.2 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase P53 PF00870.16 NM_001126114.2_2 - 1.5e-114 380.3 1.2 2e-114 379.9 1.2 1.1 1 0 0 1 1 1 1 P53 DNA-binding domain P53_TAD PF08563.9 NM_001126114.2_2 - 6.8e-12 44.4 5.3 1.6e-11 43.1 5.3 1.7 1 0 0 1 1 1 1 P53 transactivation motif DEC-1_N PF04625.11 NM_001126114.2_2 - 1.6 7.5 5.7 2.3 7.0 5.7 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region P53_tetramer PF07710.9 NM_001126114.2_3 - 2.3e-10 39.5 0.9 3.5e-10 38.9 0.9 1.3 1 0 0 1 1 1 1 P53 tetramerisation motif Methyltransf_22 PF13383.4 NM_001123364.1_1 - 9.4e-11 41.6 0.3 1.2e-10 41.3 0.3 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.10 NM_001123364.1_1 - 8.4e-06 25.8 0.0 1.1e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain FAD_binding_3 PF01494.17 NM_001282668.1_3 - 2.6e-07 30.1 0.0 4e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.12 NM_001282668.1_3 - 3.7e-06 26.3 0.0 5.7e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 NM_001282668.1_3 - 1.1e-05 24.5 0.0 1.5e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.4 NM_001282668.1_3 - 1.3e-05 24.5 0.0 1.7e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.4 NM_001282668.1_3 - 4.6e-05 23.7 0.0 7.8e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox PF00070.25 NM_001282668.1_3 - 0.00014 22.2 0.2 0.00035 20.9 0.1 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 NM_001282668.1_3 - 0.0002 21.0 0.0 0.00028 20.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.12 NM_001282668.1_3 - 0.00033 19.3 0.0 0.00046 18.9 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.4 NM_001282668.1_3 - 0.00043 20.3 0.1 0.00077 19.5 0.1 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.5 NM_001282668.1_3 - 0.0033 16.7 0.1 0.0045 16.3 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.10 NM_001282668.1_3 - 0.0042 16.0 0.0 0.0062 15.5 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.15 NM_001282668.1_3 - 0.0069 15.5 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.19 NM_001282668.1_3 - 0.043 13.0 0.0 0.065 12.4 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.20 NM_001282668.1_3 - 0.049 12.6 0.0 0.068 12.1 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A ATG16 PF08614.9 NM_005930.3_1 - 0.0092 16.0 72.1 0.013 15.5 23.7 4.3 1 1 3 4 4 4 2 Autophagy protein 16 (ATG16) IncA PF04156.12 NM_005930.3_1 - 0.2 11.3 75.7 0.34 10.5 16.0 4.7 1 1 4 5 5 5 0 IncA protein NPIP PF06409.9 NM_005930.3_1 - 0.29 10.2 17.4 0.008 15.3 7.6 2.6 3 0 0 3 3 3 0 Nuclear pore complex interacting protein (NPIP) Reo_sigmaC PF04582.10 NM_005930.3_1 - 1.5 8.0 14.1 1.1 8.5 1.8 2.4 2 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF3584 PF12128.6 NM_005930.3_1 - 6.8 3.9 57.2 21 2.3 57.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) NPIP PF06409.9 NM_001324065.1_3 - 5.6e-07 28.9 36.6 0.00029 20.0 12.1 3.9 3 2 0 3 3 3 2 Nuclear pore complex interacting protein (NPIP) IncA PF04156.12 NM_001324065.1_3 - 0.00097 18.8 14.7 0.00097 18.8 14.7 4.3 1 1 2 4 4 4 3 IncA protein PhyH PF05721.11 NM_001324065.1_3 - 0.16 12.1 0.4 0.42 10.7 0.4 1.6 1 0 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) Glyco_hydro_56 PF01630.16 NM_001200029.1_3 - 2e-121 405.0 0.0 2.5e-121 404.7 0.0 1.1 1 0 0 1 1 1 1 Hyaluronidase EGF_2 PF07974.11 NM_001200029.1_3 - 0.0022 18.2 1.1 0.0022 18.2 1.1 2.5 2 1 0 2 2 2 1 EGF-like domain EGF PF00008.25 NM_001200029.1_3 - 0.18 12.0 4.7 1.1 9.5 4.7 2.4 1 1 0 1 1 1 0 EGF-like domain Peptidase_M29 PF02073.13 NM_001200029.1_3 - 0.29 9.7 0.3 0.42 9.2 0.3 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) BUD22 PF09073.8 NM_152546.2_1 - 3.4e-11 43.0 41.9 1.1e-10 41.4 2.7 2.3 1 1 1 2 2 2 2 BUD22 FAA_hydrolase PF01557.16 NM_001320848.1_3 - 6.2e-72 241.6 0.0 7.8e-72 241.3 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Baculo_ODV-E27 PF05314.9 NM_001320848.1_3 - 0.12 11.4 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Baculovirus occlusion-derived virus envelope protein EC27 TF_Otx PF03529.11 NM_001270525.1_1 - 6.1e-32 109.8 14.6 6.1e-32 109.8 14.6 2.5 1 1 1 2 2 2 1 Otx1 transcription factor Homeobox PF00046.27 NM_001270525.1_1 - 1.9e-21 75.5 2.2 3.1e-21 74.8 2.2 1.3 1 0 0 1 1 1 1 Homeobox domain NUDE_C PF04880.11 NM_001270525.1_1 - 0.63 10.4 4.0 1.2 9.4 4.0 1.4 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region HMG_CoA_synt_C PF08540.8 NM_001324223.1_3 - 8.9e-127 422.4 1.5 1.2e-126 421.9 1.5 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.15 NM_001324223.1_3 - 1.4e-83 278.9 0.5 2e-83 278.4 0.5 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal V-set PF07686.15 NM_001321605.1_2 - 3.5e-15 55.9 0.2 5.6e-15 55.3 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Myelin-PO_C PF10570.7 NM_001321605.1_2 - 0.079 13.3 0.4 0.15 12.4 0.4 1.4 1 0 0 1 1 1 0 Myelin-PO cytoplasmic C-term p65 binding region PDZ PF00595.22 NM_080684.2_1 - 2.9e-76 251.7 8.6 6.1e-18 64.8 0.8 5.5 5 0 0 5 5 5 5 PDZ domain (Also known as DHR or GLGF) Y_phosphatase PF00102.25 NM_080684.2_1 - 2.1e-73 246.6 0.0 4e-73 245.7 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTN13_u3 PF16599.3 NM_080684.2_1 - 3.1e-73 245.8 24.2 3.1e-73 245.8 24.2 3.1 3 0 0 3 3 3 1 Unstructured linker region on PTN13 protein between PDZ FERM_M PF00373.16 NM_080684.2_1 - 1e-27 96.7 1.2 2.7e-27 95.4 1.2 1.8 1 0 0 1 1 1 1 FERM central domain PDZ_2 PF13180.4 NM_080684.2_1 - 1.2e-24 86.3 6.8 2.7e-05 24.3 0.0 5.5 5 0 0 5 5 5 4 PDZ domain FERM_C PF09380.8 NM_080684.2_1 - 1e-20 73.8 1.3 1.4e-19 70.1 0.5 2.5 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_080684.2_1 - 3.8e-16 58.6 0.1 8.8e-16 57.5 0.1 1.7 1 0 0 1 1 1 1 FERM N-terminal domain KIND PF16474.3 NM_080684.2_1 - 1.5e-05 24.8 0.0 0.00014 21.7 0.0 2.5 1 1 1 2 2 2 1 Kinase non-catalytic C-lobe domain DSPc PF00782.18 NM_080684.2_1 - 0.0024 17.6 0.0 0.0074 16.0 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 NM_080684.2_1 - 0.12 12.3 0.0 0.41 10.6 0.0 1.9 1 0 0 1 1 1 0 Inositol hexakisphosphate Folate_rec PF03024.12 NM_001113534.1_2 - 1.3e-63 213.8 25.0 1.3e-63 213.8 25.0 1.5 2 0 0 2 2 2 1 Folate receptor family zf-DHHC PF01529.18 NM_001146256.1_2 - 1.2e-33 115.9 20.9 1.2e-33 115.9 20.9 2.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase ERM PF00769.17 NM_016418.5_3 - 3.7e-64 216.7 39.5 3.7e-64 216.7 39.5 2.8 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_M PF00373.16 NM_016418.5_3 - 2.2e-26 92.4 0.9 2.2e-26 92.4 0.9 2.7 2 1 0 2 2 2 1 FERM central domain FERM_C PF09380.8 NM_016418.5_3 - 4.8e-24 84.4 0.0 1.6e-23 82.8 0.0 1.9 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_016418.5_3 - 1e-10 41.2 0.6 1e-10 41.2 0.6 2.1 2 0 0 2 2 2 1 FERM N-terminal domain SH3_1 PF00018.26 NM_004810.3_3 - 4.3e-29 99.7 0.1 8.9e-14 50.7 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 NM_004810.3_3 - 8.7e-27 92.6 2.2 8.7e-13 47.8 0.1 2.6 3 0 0 3 3 3 2 Variant SH3 domain SH2 PF00017.22 NM_004810.3_3 - 1.6e-21 76.0 0.1 2.8e-21 75.2 0.1 1.4 1 0 0 1 1 1 1 SH2 domain SH3_2 PF07653.15 NM_004810.3_3 - 3.4e-19 68.2 0.0 2.8e-09 36.4 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH2_2 PF14633.4 NM_004810.3_3 - 0.00072 18.9 0.0 0.0015 17.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain DUF2076 PF09849.7 NM_004810.3_3 - 4.3 7.2 6.4 6.5 6.6 6.4 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Calx-beta PF03160.12 NM_182932.2_2 - 7.7e-64 212.0 8.4 2.3e-32 111.0 0.6 2.4 2 0 0 2 2 2 2 Calx-beta domain Na_Ca_ex PF01699.22 NM_182932.2_2 - 1.4e-58 197.0 34.3 8e-34 116.7 12.8 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.3 NM_182932.2_2 - 5.6e-54 181.9 4.3 9.8e-54 181.1 4.3 1.4 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain Caldesmon PF02029.13 NM_001013253.1_1 - 1.5e-24 86.5 4.0 1.5e-24 86.5 4.0 2.9 3 1 0 3 3 3 2 Caldesmon zf-H2C2_2 PF13465.4 NM_001281293.1_3 - 6.4e-17 61.0 20.5 2.8e-06 27.4 0.2 4.8 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001281293.1_3 - 3e-10 39.9 33.5 0.005 17.1 0.8 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001281293.1_3 - 0.014 16.1 3.6 0.014 16.1 3.6 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001281293.1_3 - 1.2 9.0 20.1 0.25 11.2 1.3 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger GAGA PF09237.9 NM_001281293.1_3 - 1.4 8.7 6.9 0.38 10.5 1.5 2.7 2 1 0 2 2 2 0 GAGA factor DZR PF12773.5 NM_001281293.1_3 - 4.7 7.2 7.3 15 5.6 2.0 2.5 2 0 0 2 2 2 0 Double zinc ribbon FERM_M PF00373.16 NM_032428.1_1 - 1.3e-16 60.9 0.0 1.3e-16 60.9 0.0 2.5 2 0 0 2 2 1 1 FERM central domain PDZ PF00595.22 NM_032428.1_1 - 2e-09 37.5 0.0 4.3e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_032428.1_1 - 0.00013 22.0 0.0 0.0003 20.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain RP-C_C PF11800.6 NM_032428.1_1 - 0.025 14.5 5.7 0.07 13.1 5.7 1.7 1 0 0 1 1 1 0 Replication protein C C-terminal region SKA1 PF07160.10 NM_032428.1_1 - 0.041 13.6 9.5 0.1 12.3 9.5 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF4834 PF16118.3 NM_032428.1_1 - 0.049 14.5 3.4 0.16 12.9 3.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Peroxin-13_N PF04088.11 NM_032428.1_1 - 0.38 10.9 3.9 0.9 9.7 3.9 1.5 1 0 0 1 1 1 0 Peroxin 13, N-terminal region EPL1 PF10513.7 NM_032428.1_1 - 0.86 9.8 6.7 2.8 8.2 6.7 1.8 1 0 0 1 1 1 0 Enhancer of polycomb-like Anoctamin PF04547.10 NM_032428.1_1 - 1 8.0 2.9 1.7 7.2 2.9 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel ZYG-11_interact PF05884.10 NM_032428.1_1 - 1.1 8.5 7.4 1.8 7.8 7.4 1.4 1 0 0 1 1 1 0 Interactor of ZYG-11 V_ATPase_I PF01496.17 NM_032428.1_1 - 1.4 6.6 6.5 2.2 6.0 6.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rpp20 PF12328.6 NM_032428.1_1 - 1.5 8.6 8.6 3.3 7.5 8.6 1.5 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P eIF-3_zeta PF05091.10 NM_032428.1_1 - 2.2 7.0 7.9 3.7 6.3 7.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CagX PF03524.13 NM_032428.1_1 - 3 7.4 6.1 5.4 6.5 6.1 1.3 1 0 0 1 1 1 0 Conjugal transfer protein ALMT PF11744.6 NM_032428.1_1 - 3 6.4 6.6 5.1 5.7 6.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Roughex PF06020.9 NM_032428.1_1 - 3.8 6.4 9.8 7.1 5.5 9.8 1.4 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.6 NM_032428.1_1 - 4.8 6.6 32.6 0.037 13.5 23.9 1.9 2 0 0 2 2 1 0 Spt20 family Presenilin PF01080.15 NM_032428.1_1 - 5.2 5.6 7.5 14 4.2 7.5 1.6 1 0 0 1 1 1 0 Presenilin Coilin_N PF15862.3 NM_032428.1_1 - 6.6 6.4 8.8 17 5.0 8.8 1.7 1 0 0 1 1 1 0 Coilin N-terminus TERB2 PF15101.4 NM_032428.1_1 - 7 6.5 10.3 16 5.4 10.3 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 zf-CCCH PF00642.22 NM_001145125.1_1 - 1.4e-17 63.0 18.7 7.1e-07 28.9 4.0 3.6 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.3 NM_001145125.1_1 - 4.5e-15 56.2 12.3 1.8e-05 25.3 0.6 3.4 2 1 1 3 3 3 3 Torus domain zf-C3HC4 PF00097.23 NM_001145125.1_1 - 2e-06 27.4 1.9 2e-06 27.4 1.9 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_3 PF15663.3 NM_001145125.1_1 - 4.4e-06 26.8 4.0 4.4e-06 26.8 4.0 2.4 2 0 0 2 2 2 1 Zinc-finger containing family zf-RING_UBOX PF13445.4 NM_001145125.1_1 - 1.3e-05 25.0 3.2 1.6e-05 24.7 0.8 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.4 NM_001145125.1_1 - 0.00038 20.2 2.0 0.00038 20.2 2.0 2.5 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_001145125.1_1 - 0.0007 19.7 1.4 0.0007 19.7 1.4 3.7 4 1 0 4 4 4 1 Ring finger domain zf-rbx1 PF12678.5 NM_001145125.1_1 - 0.0015 18.6 1.5 0.0015 18.6 1.5 3.0 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-CCCH_2 PF14608.4 NM_001145125.1_1 - 0.0038 17.5 26.3 0.12 12.7 3.9 4.4 4 0 0 4 4 4 3 RNA-binding, Nab2-type zinc finger zf-C3HC4_2 PF13923.4 NM_001145125.1_1 - 0.0056 16.4 3.0 0.0056 16.4 3.0 3.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 NM_001145125.1_1 - 0.0086 16.0 0.7 0.0086 16.0 0.7 2.6 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 NM_001145125.1_1 - 0.013 15.5 0.5 0.013 15.5 0.5 2.9 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.3 NM_001145125.1_1 - 0.4 10.3 6.2 0.13 11.9 2.1 2.5 2 0 0 2 2 1 0 RING-like zinc finger bZIP_1 PF00170.19 NM_182723.1_1 - 1.3e-34 117.9 23.7 2e-18 66.1 13.1 2.3 2 0 0 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.13 NM_182723.1_1 - 4.3e-12 45.8 26.7 1.1e-06 28.5 13.6 2.3 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.15 NM_182723.1_1 - 0.0036 17.6 14.2 0.066 13.6 6.7 2.2 2 0 0 2 2 2 2 bZIP Maf transcription factor ASD2 PF08687.9 NM_182723.1_1 - 0.034 13.6 4.5 0.062 12.8 0.2 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 TPR_MLP1_2 PF07926.10 NM_182723.1_1 - 0.077 12.9 8.4 0.58 10.1 2.7 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4988 PF16378.3 NM_182723.1_1 - 0.16 11.4 1.7 3.1 7.2 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function Nnf1 PF03980.12 NM_182723.1_1 - 1.7 9.0 12.0 6.1 7.1 4.5 2.2 2 0 0 2 2 2 0 Nnf1 HALZ PF02183.16 NM_182723.1_1 - 2.8 8.1 7.4 11 6.2 0.6 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper TSC22 PF01166.16 NM_182723.1_1 - 4.6 7.5 7.6 4.6 7.5 0.7 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family CD52 PF15116.4 NM_004405.3_2 - 1.1 9.3 3.4 2.3 8.2 0.3 2.6 2 0 0 2 2 2 0 CAMPATH-1 antigen Homeobox PF00046.27 NM_004405.3_3 - 3.8e-20 71.3 3.2 5.7e-20 70.8 3.2 1.3 1 0 0 1 1 1 1 Homeobox domain DLL_N PF12413.6 NM_004405.3_3 - 3.5e-19 69.7 18.1 3.5e-19 69.7 18.1 2.2 3 0 0 3 3 3 1 Homeobox protein distal-less-like N terminal Homeobox_KN PF05920.9 NM_004405.3_3 - 0.035 13.9 0.1 0.07 12.9 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain 7tm_4 PF13853.4 NM_178168.1_1 - 1.9e-58 198.3 12.4 2.3e-58 198.0 12.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_178168.1_1 - 1.3e-25 90.0 19.4 5.1e-25 88.1 19.4 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) BAR PF03114.16 NM_001320634.1_1 - 8.1e-42 143.4 10.7 1.2e-41 142.8 10.7 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 NM_001320634.1_1 - 3e-10 39.7 0.1 6.7e-10 38.5 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001320634.1_1 - 1.1e-06 28.1 0.0 3.2e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001320634.1_1 - 2e-06 27.1 0.1 4.6e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.3 NM_001320634.1_1 - 0.00024 20.7 8.6 0.00047 19.8 8.0 1.7 1 1 1 2 2 2 1 BAR domain of APPL family Jnk-SapK_ap_N PF09744.7 NM_001320634.1_1 - 0.017 15.2 1.7 0.017 15.2 1.7 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 OmpH PF03938.12 NM_001320634.1_1 - 0.13 12.1 11.7 0.052 13.4 2.0 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3104 PF11302.6 NM_001320634.1_1 - 0.14 11.7 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) IncA PF04156.12 NM_001320634.1_1 - 2.3 7.8 7.2 8.7 5.9 1.1 2.3 2 0 0 2 2 2 0 IncA protein BLOC1_2 PF10046.7 NM_001320634.1_1 - 3.8 7.8 11.3 0.56 10.4 1.9 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-H2C2_2 PF13465.4 NM_007149.2_1 - 2.6e-146 470.0 147.8 3.8e-09 36.5 0.3 20.4 20 0 0 20 20 20 18 Zinc-finger double domain zf-C2H2 PF00096.24 NM_007149.2_1 - 2.9e-107 345.4 159.7 3.9e-06 26.9 1.9 19.5 19 0 0 19 19 19 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_007149.2_1 - 3.9e-54 176.4 148.7 0.0039 17.8 0.7 19.6 19 0 0 19 19 19 19 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_007149.2_1 - 2.7e-45 151.4 125.3 2e-05 24.3 0.9 19.7 19 0 0 19 19 19 19 C2H2-type zinc finger KRAB PF01352.25 NM_007149.2_1 - 2.5e-22 78.1 0.1 4.8e-22 77.2 0.1 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_007149.2_1 - 6.4e-14 51.7 111.8 0.012 15.6 3.2 12.8 2 2 16 18 18 18 18 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_007149.2_1 - 3.8e-10 39.2 99.1 0.099 12.3 1.0 18.5 19 0 0 19 19 19 9 zinc-finger C2H2-type XPA_N PF01286.16 NM_007149.2_1 - 2.2e-07 30.6 101.9 1.6 8.7 0.2 19.0 19 0 0 19 19 19 5 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_007149.2_1 - 8e-05 23.2 100.0 0.27 11.9 2.9 10.7 2 2 12 14 14 14 8 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_007149.2_1 - 0.00099 19.2 117.3 0.04 14.1 0.7 18.0 19 0 0 19 19 19 7 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_007149.2_1 - 0.016 15.4 1.9 0.016 15.4 1.9 16.7 17 0 0 17 17 16 0 Zinc-finger of C2H2 type DIL PF01843.17 NM_017805.2_3 - 3.2e-23 81.9 0.0 5.8e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 DIL domain RA PF00788.21 NM_017805.2_3 - 9.1e-11 42.1 0.0 2.1e-10 40.9 0.0 1.7 1 1 0 1 1 1 1 Ras association (RalGDS/AF-6) domain U1snRNP70_N PF12220.6 NM_003089.5_1 - 9.9e-28 96.5 6.3 9.9e-28 96.5 6.3 4.4 3 1 0 3 3 3 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.20 NM_003089.5_1 - 6.6e-18 64.2 0.0 1.1e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_003089.5_1 - 0.2 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HMG_box_2 PF09011.8 NM_001301231.1_2 - 5.6e-47 158.1 9.0 5.5e-29 100.4 6.2 2.3 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.17 NM_001301231.1_2 - 2.5e-43 146.2 8.9 1.2e-26 92.7 0.1 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_5 PF14887.4 NM_001301231.1_2 - 0.00057 19.7 7.8 0.026 14.3 0.3 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box 5 Ribosomal_60s PF00428.17 NM_001301231.1_2 - 0.88 10.0 16.3 1.6 9.2 16.3 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Reticulon PF02453.15 NM_201428.2_2 - 1.7e-42 144.9 10.9 2.8e-42 144.2 10.9 1.4 1 0 0 1 1 1 1 Reticulon Cpn60_TCP1 PF00118.22 NM_001306153.1_3 - 5.2e-159 529.9 8.6 6.4e-159 529.6 8.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family 4HBT PF03061.20 NM_181865.2_2 - 3.1e-32 110.6 3.2 3.6e-16 59.2 0.3 2.3 2 0 0 2 2 2 2 Thioesterase superfamily tRNA_anti-codon PF01336.23 NM_181865.2_2 - 0.0015 18.4 0.0 0.024 14.5 0.0 2.4 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain NINJA_B PF16136.3 NM_181865.2_2 - 0.0062 16.8 0.6 0.0062 16.8 0.6 2.3 2 0 0 2 2 2 1 Putative nuclear localisation signal IRF-3 PF10401.7 NM_001242452.2_2 - 4e-70 235.1 0.2 5.4e-70 234.7 0.2 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 NM_001242452.2_2 - 1.2e-38 131.5 0.0 1.9e-38 130.8 0.0 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Amino_oxidase PF01593.22 NM_032709.2_3 - 1.2e-12 47.8 0.8 6.7e-07 28.8 0.0 2.6 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 NM_032709.2_3 - 4.7e-10 39.4 0.1 1.2e-09 38.2 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.12 NM_032709.2_3 - 4.3e-06 26.1 0.1 0.00076 18.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 NM_032709.2_3 - 6.3e-06 26.5 2.9 0.0099 16.3 1.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 NM_032709.2_3 - 1.9e-05 24.3 4.1 0.0013 18.3 4.2 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.15 NM_032709.2_3 - 8.4e-05 21.8 0.4 0.00026 20.2 0.1 1.8 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.20 NM_032709.2_3 - 0.00013 21.1 2.2 0.0034 16.4 1.6 2.5 3 0 0 3 3 3 1 Glucose inhibited division protein A FAD_oxidored PF12831.5 NM_032709.2_3 - 0.00014 21.2 0.1 0.00034 19.9 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 NM_032709.2_3 - 0.00041 19.4 4.6 0.0022 17.0 2.6 2.1 2 0 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.17 NM_032709.2_3 - 0.0017 17.5 0.1 0.0027 16.9 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.19 NM_032709.2_3 - 0.026 13.7 0.6 0.058 12.6 0.1 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.12 NM_032709.2_3 - 0.03 13.0 1.4 4 6.0 0.2 2.1 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.12 NM_032709.2_3 - 0.079 11.5 1.7 0.072 11.6 0.4 1.6 2 0 0 2 2 2 0 HI0933-like protein SPRY PF00622.26 NM_033289.1_3 - 3.7e-17 62.4 0.0 6.1e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_033289.1_3 - 1.5e-12 46.8 0.2 1.5e-11 43.6 0.0 2.3 2 0 0 2 2 2 1 SPRY-associated domain fn3 PF00041.19 NM_033289.1_3 - 8.1e-08 32.4 0.2 1.6e-07 31.5 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_UBOX PF13445.4 NM_033289.1_3 - 3.8e-07 29.9 9.0 3.8e-07 29.9 9.0 3.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_033289.1_3 - 3e-06 26.8 8.4 3e-06 26.8 8.4 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_033289.1_3 - 1.3e-05 24.9 11.7 1.3e-05 24.9 11.7 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_033289.1_3 - 1.6e-05 24.9 12.0 1.6e-05 24.9 12.0 4.3 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 NM_033289.1_3 - 0.0001 22.3 11.4 0.0001 22.3 11.4 3.7 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_033289.1_3 - 0.00056 19.6 11.1 0.00056 19.6 11.1 4.3 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Pur_ac_phosph_N PF16656.3 NM_033289.1_3 - 0.035 14.5 0.2 0.072 13.5 0.2 1.5 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain zf-B_box PF00643.22 NM_033289.1_3 - 7.6 6.7 16.6 0.053 13.5 5.0 3.1 2 0 0 2 2 2 0 B-box zinc finger LRR_8 PF13855.4 NM_181847.4_2 - 1.2e-29 101.8 26.2 8.9e-14 50.9 3.7 4.1 1 1 3 5 5 5 3 Leucine rich repeat LRR_4 PF12799.5 NM_181847.4_2 - 3.9e-12 46.0 14.8 9.4e-06 25.7 0.3 4.1 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) ig PF00047.23 NM_181847.4_2 - 2.2e-06 27.6 0.0 6.7e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.4 NM_181847.4_2 - 3.1e-06 27.0 0.3 6e-06 26.1 0.3 1.4 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) Ig_3 PF13927.4 NM_181847.4_2 - 6.6e-06 26.5 0.0 1.5e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_181847.4_2 - 0.00078 19.6 0.0 0.0023 18.1 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.4 NM_181847.4_2 - 0.001 18.5 3.3 0.0017 17.8 1.4 2.0 2 1 0 2 2 2 1 Leucine-rich repeat I-set PF07679.14 NM_181847.4_2 - 0.001 19.0 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.15 NM_181847.4_2 - 0.038 14.0 0.0 0.1 12.6 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin V-set domain LRR_6 PF13516.4 NM_181847.4_2 - 0.049 13.6 11.4 2.9 8.0 0.2 4.9 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.31 NM_181847.4_2 - 0.053 13.9 13.0 12 6.8 0.0 6.6 7 0 0 7 7 7 0 Leucine Rich Repeat DUF676 PF05057.12 NM_020819.4_1 - 3.2e-61 206.5 0.0 5.1e-61 205.8 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3657 PF12394.6 NM_020819.4_1 - 5.3e-18 65.2 3.6 8.3e-18 64.5 1.3 2.7 2 0 0 2 2 2 1 Protein FAM135 PGAP1 PF07819.11 NM_020819.4_1 - 2.7e-05 23.9 0.0 6.6e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.13 NM_020819.4_1 - 0.0011 18.1 0.1 0.0021 17.2 0.1 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase FAM176 PF14851.4 NM_020819.4_1 - 0.061 12.9 3.3 0.19 11.3 3.3 1.8 1 0 0 1 1 1 0 FAM176 family CRAL_TRIO PF00650.18 NM_001161368.1_2 - 3.4e-40 137.2 0.0 5e-40 136.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.4 NM_001161368.1_2 - 2.8e-06 27.3 0.0 4.7e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.13 NM_001161368.1_2 - 0.00033 20.6 0.8 0.00066 19.7 0.8 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain GOLD_2 PF13897.4 NM_001161368.1_2 - 0.0062 16.9 0.0 0.01 16.2 0.0 1.3 1 0 0 1 1 1 1 Golgi-dynamics membrane-trafficking zf-RING_UBOX PF13445.4 NM_006074.4_2 - 4e-11 42.6 6.3 5e-11 42.3 3.6 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 NM_006074.4_2 - 6.9e-11 42.0 8.4 6.9e-11 42.0 8.4 2.0 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 NM_006074.4_2 - 1.4e-09 37.5 7.2 3.5e-09 36.3 7.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 NM_006074.4_2 - 2e-08 34.1 4.0 2e-08 34.1 4.0 3.2 4 0 0 4 4 2 1 B-box zinc finger zf-C3HC4_2 PF13923.4 NM_006074.4_2 - 5.5e-08 32.4 6.7 5.1e-07 29.3 7.5 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SPRY PF00622.26 NM_006074.4_2 - 1.4e-07 31.5 1.2 2e-07 31.0 0.2 1.8 2 0 0 2 2 2 1 SPRY domain zf-RING_2 PF13639.4 NM_006074.4_2 - 1.4e-06 28.3 7.0 1.4e-06 28.3 7.0 2.2 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_006074.4_2 - 6.3e-06 25.9 5.8 6.3e-06 25.9 5.8 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 NM_006074.4_2 - 1.1e-05 25.1 5.3 1.1e-05 25.1 5.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 NM_006074.4_2 - 0.0021 17.8 4.1 0.0065 16.2 4.1 1.9 1 1 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 NM_006074.4_2 - 0.0023 17.6 8.4 0.025 14.3 8.9 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-Nse PF11789.6 NM_006074.4_2 - 0.0072 16.0 4.3 0.019 14.7 4.3 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.13 NM_006074.4_2 - 0.012 15.7 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 U-box domain YojJ PF10372.7 NM_006074.4_2 - 0.25 11.3 1.7 16 5.5 0.2 2.6 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus zf-RING_4 PF14570.4 NM_006074.4_2 - 0.33 10.6 3.8 1.4 8.6 4.0 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.3 NM_006074.4_2 - 3.3 7.8 15.3 0.019 14.9 4.1 2.4 1 1 1 2 2 2 0 zinc RING finger of MSL2 zf-rbx1 PF12678.5 NM_006074.4_2 - 7.2 6.9 13.2 0.059 13.5 3.7 2.4 2 1 0 2 2 1 0 RING-H2 zinc finger domain CS PF04969.14 NM_001282603.1_2 - 7.1e-05 23.6 0.0 0.00013 22.8 0.0 1.4 1 0 0 1 1 1 1 CS domain Pkinase_C PF00433.22 NM_001282603.1_2 - 2.1 9.0 5.3 4.7 7.9 5.3 1.6 1 0 0 1 1 1 0 Protein kinase C terminal domain Rrn6 PF10214.7 NM_001282603.1_3 - 1.3 7.2 7.6 1.8 6.7 7.6 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor PAP2 PF01569.19 NM_003713.4_2 - 4.6e-28 97.6 1.0 9.5e-28 96.6 1.0 1.6 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 NM_003713.4_2 - 0.00012 22.4 2.3 0.00037 20.8 2.3 1.8 1 0 0 1 1 1 1 PAP2 superfamily C-terminal PAP2_3 PF14378.4 NM_003713.4_2 - 0.026 14.1 0.3 0.047 13.2 0.3 1.4 1 0 0 1 1 1 0 PAP2 superfamily C1-set_C PF16196.3 NM_003713.4_2 - 0.041 13.2 0.0 0.08 12.2 0.0 1.4 1 0 0 1 1 1 0 C1-set C-terminal domain Atg14 PF10186.7 NM_144978.2_2 - 0.058 12.3 14.7 0.12 11.3 14.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2968 PF11180.6 NM_144978.2_2 - 0.066 12.8 7.9 0.14 11.8 7.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Mt_ATP-synt_D PF05873.10 NM_144978.2_2 - 0.081 12.6 4.0 0.11 12.2 2.7 1.9 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) UPF0184 PF03670.11 NM_144978.2_2 - 0.13 12.5 2.1 0.32 11.3 2.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Spc7 PF08317.9 NM_144978.2_2 - 0.23 10.1 18.9 0.46 9.2 18.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein LPP PF04728.11 NM_144978.2_2 - 1.6 9.0 5.8 0.81 10.0 3.0 2.0 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Exonuc_VII_L PF02601.13 NM_144978.2_2 - 5 6.5 9.2 9.1 5.6 9.2 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit CD20 PF04103.13 NM_001101311.1_1 - 2.2e-43 147.9 7.3 3.1e-43 147.4 7.3 1.2 1 0 0 1 1 1 1 CD20-like family PGM_PMM_I PF02878.14 NM_001172818.1_3 - 2.1e-35 121.3 0.0 3.2e-35 120.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.14 NM_001172818.1_3 - 8e-31 106.5 0.0 1.3e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.14 NM_001172818.1_3 - 3e-17 63.0 0.0 5.6e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.18 NM_001172818.1_3 - 2.1e-05 24.5 0.0 5e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Pkinase PF00069.23 NM_001323376.1_2 - 0.0016 17.7 0.1 0.0022 17.2 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.23 NM_001323376.1_3 - 4.8e-50 170.2 0.0 7e-50 169.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001323376.1_3 - 5.3e-15 55.3 0.0 8.4e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001323376.1_3 - 0.00093 18.5 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Acyltransferase PF01553.19 NM_018361.3_1 - 2.8e-16 59.2 0.0 4.6e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.3 NM_018361.3_1 - 2.9e-15 56.0 0.7 5.2e-15 55.2 0.7 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus EGF_CA PF07645.13 NM_001999.3_2 - 0 1067.8 708.4 9.5e-11 41.6 6.2 48.1 45 1 2 47 47 47 44 Calcium-binding EGF domain cEGF PF12662.5 NM_001999.3_2 - 1.9e-224 724.5 425.2 9.4e-10 38.1 1.8 51.0 50 0 0 50 50 50 44 Complement Clr-like EGF-like EGF PF00008.25 NM_001999.3_2 - 2e-109 357.2 698.5 6.1e-05 23.1 6.2 49.8 49 0 0 49 49 49 44 EGF-like domain TB PF00683.15 NM_001999.3_2 - 1e-103 338.7 135.9 2.5e-14 52.6 7.7 11.2 9 0 0 9 9 9 9 TB domain FXa_inhibition PF14670.4 NM_001999.3_2 - 4.7e-98 321.0 718.4 3.8e-09 36.5 10.5 49.6 46 3 3 49 49 49 42 Coagulation Factor Xa inhibitory site hEGF PF12661.5 NM_001999.3_2 - 1.6e-77 253.7 680.9 0.00044 20.7 5.9 53.4 53 0 0 53 53 53 42 Human growth factor-like EGF EGF_3 PF12947.5 NM_001999.3_2 - 1.8e-34 117.5 648.0 1.3e-09 37.9 12.0 50.0 48 2 2 50 50 50 37 EGF domain Cadherin PF00028.15 NM_001999.3_2 - 0.19 12.0 0.0 0.4 11.0 0.0 1.4 1 0 0 1 1 1 0 Cadherin domain Plasmod_Pvs28 PF06247.9 NM_001999.3_2 - 7.4 6.8 531.0 0.041 14.1 5.3 45.5 43 3 2 45 45 45 0 Pvs28 EGF domain GST_N_4 PF17172.2 NM_001319097.1_2 - 2.9e-24 85.6 0.0 5.2e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.2 NM_001319097.1_2 - 1e-23 82.7 0.2 1.9e-23 81.9 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.7 NM_001319097.1_2 - 2.1e-21 76.4 0.0 3.9e-21 75.5 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.4 NM_001319097.1_2 - 1.4e-05 24.8 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_001319097.1_2 - 0.075 13.1 0.1 0.2 11.7 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain BTB PF00651.29 NM_001007230.1_2 - 9.1e-33 112.7 1.3 2e-32 111.6 0.3 1.9 1 1 1 2 2 2 1 BTB/POZ domain MATH PF00917.24 NM_001007230.1_2 - 4.3e-06 26.7 0.0 1.2e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 MATH domain BACK PF07707.13 NM_001007230.1_2 - 0.019 15.0 0.2 0.39 10.7 0.0 2.7 3 0 0 3 3 3 0 BTB And C-terminal Kelch AMP-binding PF00501.26 NM_001242393.1_1 - 7.8e-98 327.7 0.0 9.7e-98 327.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 NM_001242393.1_1 - 8.1e-25 87.5 0.1 1.5e-24 86.7 0.1 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.3 NM_001242393.1_1 - 2e-13 49.9 0.9 5.7e-13 48.4 0.9 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus SSXT PF05030.10 NM_198935.2_3 - 1.4e-31 107.7 5.1 3.1e-31 106.7 5.1 1.6 1 0 0 1 1 1 1 SSXT protein (N-terminal region) START PF01852.17 NM_000349.2_1 - 9.8e-56 188.3 0.0 1.3e-55 187.9 0.0 1.2 1 0 0 1 1 1 1 START domain Polyketide_cyc PF03364.18 NM_000349.2_1 - 0.071 13.2 0.0 0.52 10.4 0.0 2.4 2 1 0 2 2 2 0 Polyketide cyclase / dehydrase and lipid transport KRAB PF01352.25 NM_001242713.1_1 - 5.9e-23 80.1 0.1 8.7e-23 79.6 0.1 1.3 1 0 0 1 1 1 1 KRAB box CENP-N PF05238.11 NM_001100625.2_2 - 6.1e-64 216.7 6.4 2e-63 215.0 6.4 1.7 1 1 0 1 1 1 1 Kinetochore protein CHL4 like Carb_anhydrase PF00194.19 NM_001739.1_3 - 1.4e-87 293.3 0.0 1.8e-87 293.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Forkhead PF00250.16 NM_005938.3_3 - 3.4e-25 88.1 0.1 5.9e-25 87.3 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain FOXO-TAD PF16676.3 NM_005938.3_3 - 5.8e-17 61.7 12.6 9.8e-17 61.0 12.6 1.4 1 0 0 1 1 1 1 Transactivation domain of FOXO protein family FOXO_KIX_bdg PF16675.3 NM_005938.3_3 - 6.4e-06 26.2 0.1 1.4e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 KIX-binding domain of forkhead box O, CR2 Adaptin_binding PF10199.7 NM_001271885.1_2 - 4.3e-17 62.7 0.0 6.5e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Ras PF00071.20 NM_001271885.1_2 - 0.097 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Ras family WD40 PF00400.30 NM_181676.2_2 - 4.3e-09 36.7 4.2 1.9 9.4 0.1 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_181676.2_2 - 0.00044 20.4 0.2 4.5 7.5 0.0 4.7 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_9 PF13901.4 NM_025113.3_3 - 1.2e-66 224.4 17.5 1.2e-66 224.4 17.5 1.9 2 0 0 2 2 2 1 Putative zinc-RING and/or ribbon zf-C4 PF00105.16 NM_001145425.1_1 - 1.3e-30 105.5 15.7 3e-30 104.4 15.7 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001145425.1_1 - 2.2e-24 86.1 0.4 4e-24 85.2 0.4 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor LpxD PF04613.12 NM_001145425.1_1 - 0.16 11.7 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD BAR_3 PF16746.3 NM_002547.2_1 - 7.9e-77 258.0 20.0 1.1e-76 257.6 20.0 1.2 1 0 0 1 1 1 1 BAR domain of APPL family RhoGAP PF00620.25 NM_002547.2_1 - 3.8e-41 140.3 0.0 8.5e-41 139.2 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 NM_002547.2_1 - 1.1e-06 29.0 0.1 2.3e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 PH domain Arfaptin PF06456.11 NM_002547.2_1 - 0.19 11.1 5.6 0.37 10.2 5.6 1.4 1 0 0 1 1 1 0 Arfaptin-like domain MBT PF02820.16 NM_031488.4_1 - 1.6e-95 313.3 3.6 5.7e-28 96.9 0.1 4.4 4 0 0 4 4 4 4 mbt repeat DUF3649 PF12365.6 NM_031488.4_1 - 0.44 10.1 5.5 1.3 8.7 5.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3649) NHR2 PF08788.9 NM_001198625.1_2 - 4e-39 132.1 8.8 8.3e-39 131.1 8.8 1.6 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 NM_001198625.1_2 - 7.7e-34 115.5 1.6 1.3e-33 114.8 1.6 1.4 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.16 NM_001198625.1_2 - 4e-07 29.9 18.2 1.4e-06 28.1 18.2 2.1 1 0 0 1 1 1 1 MYND finger DUF3731 PF12531.6 NM_001198625.1_2 - 0.082 12.6 0.8 0.14 11.8 0.8 1.2 1 0 0 1 1 1 0 DNA-K related protein Efg1 PF10153.7 NM_001198625.1_2 - 0.18 12.0 1.9 0.4 10.9 1.9 1.5 1 0 0 1 1 1 0 rRNA-processing protein Efg1 vATP-synt_E PF01991.16 NM_001198625.1_2 - 6.2 6.0 11.1 9.6 5.4 11.1 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit zf-H2C2_2 PF13465.4 NM_001305203.1_3 - 9.4e-86 278.6 99.0 1.4e-08 34.6 0.2 16.9 16 1 0 16 16 16 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001305203.1_3 - 3.3e-60 197.2 102.7 3.1e-06 27.2 1.3 14.6 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001305203.1_3 - 1.8e-33 112.2 96.3 0.0042 17.7 2.9 14.2 13 0 0 13 13 13 13 C2H2-type zinc finger KRAB PF01352.25 NM_001305203.1_3 - 4.7e-25 86.9 0.3 8.9e-25 86.0 0.3 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001305203.1_3 - 4.6e-20 71.0 84.0 0.017 15.0 1.1 13.4 13 0 0 13 13 13 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001305203.1_3 - 5.4e-14 51.9 53.0 0.12 12.6 0.1 12.6 12 0 0 12 12 12 8 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001305203.1_3 - 4.2e-07 29.8 66.2 0.025 14.6 3.7 9.7 5 3 4 10 10 10 8 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001305203.1_3 - 0.0015 18.1 66.8 0.053 13.2 0.5 12.6 13 0 0 13 13 13 7 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_001305203.1_3 - 0.016 15.8 50.0 0.79 10.4 3.9 7.7 3 1 6 9 9 9 0 zinc-ribbon family DUF4023 PF13215.4 NM_001145729.1_3 - 4.4 7.2 10.0 18 5.3 0.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4023) MHC_I_3 PF16497.3 NM_001764.2_1 - 2.9e-73 245.5 0.0 3.9e-73 245.0 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 NM_001764.2_1 - 5.4e-11 42.7 0.0 4.4e-10 39.8 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 NM_001764.2_1 - 0.0013 18.1 0.0 0.0027 17.2 0.0 1.5 1 1 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 NM_001764.2_1 - 0.045 14.2 0.2 1 9.9 0.2 2.4 1 1 1 2 2 2 0 Immunoglobulin domain RanGAP1_C PF07834.9 NM_001317930.1_1 - 6.1e-74 247.4 0.2 6.1e-74 247.4 0.2 1.5 2 0 0 2 2 1 1 RanGAP1 C-terminal domain LRR_6 PF13516.4 NM_001317930.1_1 - 8.7e-15 53.3 3.2 0.24 11.4 0.0 8.7 9 0 0 9 9 9 4 Leucine Rich repeat LRR_4 PF12799.5 NM_001317930.1_1 - 7.2e-05 22.9 3.1 3.3 8.1 0.0 5.0 4 1 2 6 6 6 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_001317930.1_1 - 0.00031 20.3 0.1 1.7 8.3 0.0 4.5 4 1 0 4 4 4 1 Leucine rich repeat SDA1 PF05285.10 NM_001317930.1_1 - 0.00063 19.2 12.6 0.0011 18.4 12.6 1.3 1 0 0 1 1 1 1 SDA1 CPSF100_C PF13299.4 NM_001317930.1_1 - 0.0065 16.5 7.6 0.011 15.8 7.6 1.3 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Nop14 PF04147.10 NM_001317930.1_1 - 0.022 12.9 17.3 0.033 12.3 17.3 1.2 1 0 0 1 1 1 0 Nop14-like family IFN-gamma PF00714.15 NM_001317930.1_1 - 0.023 14.4 0.2 0.041 13.6 0.2 1.3 1 0 0 1 1 1 0 Interferon gamma LRR_1 PF00560.31 NM_001317930.1_1 - 0.054 13.8 2.8 67 4.4 0.0 5.3 6 0 0 6 6 5 0 Leucine Rich Repeat SpoIIP PF07454.9 NM_001317930.1_1 - 0.11 11.8 5.7 0.18 11.1 5.7 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4471 PF14740.4 NM_001317930.1_1 - 0.14 11.1 0.3 0.22 10.6 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) CobT PF06213.10 NM_001317930.1_1 - 0.18 11.0 23.6 0.37 10.0 23.6 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Mpp10 PF04006.10 NM_001317930.1_1 - 0.2 9.9 20.5 0.3 9.4 20.5 1.1 1 0 0 1 1 1 0 Mpp10 protein DNA_pol_phi PF04931.11 NM_001317930.1_1 - 0.26 9.2 25.9 0.39 8.6 25.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi BUD22 PF09073.8 NM_001317930.1_1 - 0.36 10.0 17.8 0.62 9.2 17.8 1.3 1 0 0 1 1 1 0 BUD22 DUF4820 PF16091.3 NM_001317930.1_1 - 0.37 10.0 1.9 0.62 9.3 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Presenilin PF01080.15 NM_001317930.1_1 - 0.48 9.0 2.8 0.67 8.5 2.8 1.1 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.12 NM_001317930.1_1 - 0.56 10.5 5.5 0.94 9.8 5.5 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 PI3K_1B_p101 PF10486.7 NM_001317930.1_1 - 0.76 7.3 3.9 1.1 6.8 3.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.12 NM_001317930.1_1 - 1.1 7.4 15.2 1.6 6.8 15.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.6 NM_001317930.1_1 - 1.2 7.7 7.5 1.8 7.1 7.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Paf1 PF03985.11 NM_001317930.1_1 - 1.9 7.2 23.6 2.8 6.7 23.6 1.1 1 0 0 1 1 1 0 Paf1 THOC2_N PF16134.3 NM_001317930.1_1 - 2 6.8 17.8 0.95 7.9 0.3 2.2 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus Cnd2 PF05786.12 NM_001317930.1_1 - 2 6.8 12.9 2.8 6.3 12.9 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 DUF1510 PF07423.9 NM_001317930.1_1 - 3.7 6.8 20.7 5.9 6.1 20.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Sigma70_ner PF04546.11 NM_001317930.1_1 - 4.1 7.1 22.0 8.7 6.0 22.0 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region RR_TM4-6 PF06459.10 NM_001317930.1_1 - 4.2 7.0 14.1 6.8 6.3 14.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_pol_3_Rpc31 PF11705.6 NM_001317930.1_1 - 4.8 7.2 25.8 8.8 6.3 25.8 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Merozoite_SPAM PF07133.9 NM_001317930.1_1 - 4.9 7.0 36.7 9.1 6.1 36.7 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) XAP5 PF04921.12 NM_001317930.1_1 - 6.4 6.4 10.9 11 5.6 10.9 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator PPP4R2 PF09184.9 NM_001317930.1_1 - 6.6 6.1 19.6 11 5.3 19.6 1.3 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.10 NM_001317930.1_1 - 7.6 5.7 19.3 13 4.9 19.3 1.3 1 0 0 1 1 1 0 NOA36 protein DARPP-32 PF05395.10 NM_001317930.1_1 - 9.7 6.3 19.1 19 5.3 19.1 1.4 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 Thyroglobulin_1 PF00086.16 NM_000599.3_1 - 5.1e-18 64.4 2.5 1.4e-17 63.0 2.5 1.8 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 NM_000599.3_1 - 1.9e-10 41.1 22.4 6.9e-10 39.3 22.4 2.1 1 0 0 1 1 1 1 Insulin-like growth factor binding protein DUF3844 PF12955.5 NM_000599.3_2 - 0.24 11.4 1.6 0.67 10.0 1.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) Connexin PF00029.17 NM_000599.3_2 - 0.56 9.8 5.1 1.1 8.9 5.1 1.4 1 0 0 1 1 1 0 Connexin RUN PF02759.17 NM_001278230.1_3 - 2.6e-20 72.6 0.1 3.8e-20 72.1 0.1 1.3 1 0 0 1 1 1 1 RUN domain SH3_9 PF14604.4 NM_001278230.1_3 - 1.1e-10 41.0 0.0 2.4e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001278230.1_3 - 8.6e-10 37.9 0.0 1.6e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001278230.1_3 - 8.3e-08 31.7 0.0 2.8e-07 30.0 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain DUF4587 PF15248.4 NM_001191029.1_3 - 9.1e-25 87.1 1.5 9.1e-25 87.1 1.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4587) ANF_receptor PF01094.26 NM_181874.2_2 - 4.7e-104 348.1 0.0 6.3e-104 347.7 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 NM_181874.2_2 - 5.1e-60 203.0 14.1 1e-59 202.0 14.1 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 NM_181874.2_2 - 1.2e-14 53.9 16.8 2.7e-14 52.8 16.8 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 NM_181874.2_2 - 1.6e-09 37.8 0.0 7e-09 35.7 0.0 1.8 1 1 0 1 1 1 1 Periplasmic binding protein zf-C2H2 PF00096.24 NM_003709.3_2 - 1.1e-09 38.1 35.9 0.00059 20.0 8.7 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_003709.3_2 - 4.2e-06 26.8 14.2 0.00021 21.4 0.8 4.9 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_003709.3_2 - 0.00028 21.3 25.4 0.12 13.1 6.1 5.3 3 0 0 3 3 3 3 C2H2-type zinc finger B9-C2 PF07162.9 NM_001321217.1_2 - 4e-48 163.7 0.0 5.6e-48 163.2 0.0 1.2 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein BET PF17035.3 NM_001242808.2_2 - 6.1e-28 96.7 0.1 2.2e-27 94.9 0.1 2.1 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRD4_CDT PF17105.3 NM_001242808.2_2 - 1.5e-22 78.8 5.3 4.6e-22 77.2 5.3 1.9 1 0 0 1 1 1 1 C-terminal domain of bromodomain protein 4 Bromodomain PF00439.23 NM_001242808.2_2 - 3e-20 71.9 1.3 7.2e-19 67.5 0.7 2.6 2 0 0 2 2 2 1 Bromodomain DUF2079 PF09852.7 NM_001242808.2_2 - 0.12 11.1 0.3 0.18 10.5 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) 7tm_1 PF00001.19 NM_001006626.1_2 - 8.1e-73 244.8 5.3 1.8e-72 243.6 5.3 1.6 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_001006626.1_2 - 8.4e-06 25.6 5.3 8.4e-06 25.6 5.3 2.2 2 1 0 3 3 3 1 Olfactory receptor Macoilin PF09726.7 NM_001006626.1_2 - 3.6 5.9 7.3 0.23 9.8 2.3 1.4 2 0 0 2 2 2 0 Transmembrane protein Sarcoglycan_1 PF04790.11 NM_000337.5_1 - 4.5e-78 262.1 0.0 6.4e-78 261.6 0.0 1.2 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.7 NM_000337.5_1 - 0.027 14.2 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2345) Y_phosphatase PF00102.25 NM_133177.3_1 - 2.6e-133 442.7 0.1 7.2e-75 251.4 0.0 2.7 3 0 0 3 3 3 2 Protein-tyrosine phosphatase MAM PF00629.21 NM_133177.3_1 - 3.6e-35 121.1 0.0 7.4e-35 120.0 0.0 1.6 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu fn3 PF00041.19 NM_133177.3_1 - 1.5e-29 102.0 0.2 1.7e-12 47.4 0.0 4.6 4 0 0 4 4 4 3 Fibronectin type III domain DSPc PF00782.18 NM_133177.3_1 - 3.7e-06 26.6 0.4 0.11 12.1 0.1 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_133177.3_1 - 0.00019 21.3 0.2 0.035 13.9 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_133177.3_1 - 0.00038 20.5 0.0 0.13 12.2 0.0 2.4 2 0 0 2 2 2 2 Inositol hexakisphosphate Pur_ac_phosph_N PF16656.3 NM_133177.3_1 - 0.0052 17.2 0.1 0.31 11.5 0.0 3.3 3 1 1 4 4 4 1 Purple acid Phosphatase, N-terminal domain PsbX PF06596.9 NM_133177.3_1 - 2.8 7.9 4.6 6.9 6.6 4.6 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) MIP PF00230.18 NM_001102467.1_1 - 5.1e-08 32.8 4.0 7.7e-08 32.2 4.0 1.2 1 0 0 1 1 1 1 Major intrinsic protein 7tm_4 PF13853.4 NM_207374.3_1 - 3.3e-42 145.0 23.0 4.4e-42 144.6 23.0 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207374.3_1 - 1.1e-21 77.1 18.7 1.9e-21 76.3 18.7 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1082 PF06449.9 NM_207374.3_1 - 0.041 13.6 0.8 0.35 10.6 0.2 2.5 2 0 0 2 2 2 0 Mitochondrial domain of unknown function (DUF1082) Trypsin PF00089.24 NM_002658.4_3 - 3.6e-69 232.8 0.1 4.9e-69 232.4 0.1 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 NM_002658.4_3 - 3.4e-22 78.4 2.9 7.1e-22 77.4 2.9 1.6 1 0 0 1 1 1 1 Kringle domain DUF316 PF03761.13 NM_002658.4_3 - 0.00013 21.5 0.0 0.08 12.4 0.0 2.2 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 Trypsin_2 PF13365.4 NM_002658.4_3 - 0.037 14.8 0.0 0.081 13.7 0.0 1.5 1 0 0 1 1 1 0 Trypsin-like peptidase domain EGF PF00008.25 NM_002658.4_3 - 0.11 12.7 6.8 0.51 10.6 6.8 2.3 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.11 NM_002658.4_3 - 3.8 7.8 10.5 21 5.5 10.5 2.4 1 0 0 1 1 1 0 EGF-like domain zf-H2C2_2 PF13465.4 NM_001174095.1_1 - 8.6e-28 95.4 57.8 1.1e-07 31.8 5.1 7.9 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001174095.1_1 - 2.2e-23 81.2 66.2 0.00018 21.6 5.0 8.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001174095.1_1 - 3.9e-13 48.9 62.2 0.051 14.3 4.4 8.0 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001174095.1_1 - 1.1e-07 31.8 47.4 0.018 15.2 1.7 7.8 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 NM_001174095.1_1 - 1.6e-07 31.4 25.9 2.7e-07 30.6 1.4 3.9 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 NM_001174095.1_1 - 1.3e-05 25.2 52.7 0.039 14.2 2.4 7.3 7 0 0 7 7 7 5 Zinc-finger of C2H2 type Homeobox PF00046.27 NM_001174095.1_1 - 3.6e-05 23.4 0.0 9e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Homeobox domain zf-C2H2_6 PF13912.4 NM_001174095.1_1 - 0.0026 17.5 58.8 0.88 9.5 0.8 7.7 7 0 0 7 7 7 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001174095.1_1 - 0.95 9.5 21.4 0.15 12.1 2.9 4.6 4 0 0 4 4 4 0 Zinc ribbon domain zf-C2H2_9 PF16293.3 NM_001174095.1_1 - 3.6 7.4 16.7 6.9 6.5 0.1 4.9 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.5 NM_001174095.1_1 - 4.1 7.6 42.9 0.14 12.4 2.3 6.2 2 2 3 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.3 NM_001174095.1_1 - 5.7 6.7 27.6 0.16 11.6 0.5 5.6 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-B_box PF00643.22 NM_015294.4_2 - 1e-08 35.0 8.7 1e-08 35.0 8.7 3.2 2 1 0 2 2 2 1 B-box zinc finger MATH PF00917.24 NM_015294.4_2 - 1.3e-07 31.5 0.0 3.7e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 MATH domain zf-C3HC4_3 PF13920.4 NM_015294.4_2 - 3.6e-05 23.4 15.2 3.6e-05 23.4 15.2 4.2 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_015294.4_2 - 0.0053 16.5 17.1 0.0053 16.5 17.1 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) MRFAP1 PF15155.4 NM_015294.4_2 - 0.26 11.7 3.8 0.26 11.7 1.5 2.1 2 0 0 2 2 2 0 MORF4 family-associated protein1 FUSC PF04632.10 NM_015294.4_2 - 0.36 9.2 2.7 0.6 8.5 2.7 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF148 PF02520.15 NM_015294.4_2 - 1.1 9.3 4.4 0.47 10.4 1.4 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF148 DUF2203 PF09969.7 NM_015294.4_2 - 2.9 8.5 5.6 48 4.6 3.1 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Baculo_PEP_C PF04513.10 NM_015294.4_2 - 9.1 6.2 10.2 2.1 8.3 2.4 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Asp_Arg_Hydrox PF05118.13 NM_020437.4_2 - 4.3e-50 169.5 0.0 6.3e-50 168.9 0.0 1.3 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase YqhR PF11085.6 NM_020437.4_2 - 0.16 11.8 0.7 9 6.1 0.2 2.2 2 0 0 2 2 2 0 Conserved membrane protein YqhR NUDIX_5 PF16705.3 NM_194454.1_3 - 6.6e-85 283.2 0.0 1e-84 282.6 0.0 1.3 1 0 0 1 1 1 1 NUDIX, or N-terminal NPxY motif-rich, region of KRIT FERM_M PF00373.16 NM_194454.1_3 - 2.4e-19 69.7 0.1 5.9e-19 68.5 0.1 1.7 1 0 0 1 1 1 1 FERM central domain Ank_2 PF12796.5 NM_194454.1_3 - 1.4e-15 57.5 0.0 2.2e-06 28.0 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_194454.1_3 - 8.8e-13 48.1 0.1 1.2e-08 34.9 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_194454.1_3 - 4.1e-10 39.9 0.4 9.3e-07 29.2 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 NM_194454.1_3 - 4.7e-09 36.2 0.0 0.07 13.5 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 NM_194454.1_3 - 7.6e-05 22.7 0.1 0.22 12.1 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat GFO_IDH_MocA_C PF02894.15 NM_001242630.1_3 - 0.00048 20.0 0.2 0.00094 19.0 0.2 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain BRICHOS PF04089.12 NM_001287241.1_3 - 1e-20 73.5 0.0 1.6e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain Tmemb_18A PF09771.7 NM_153261.5_3 - 1.6e-56 189.6 0.0 2.6e-56 189.0 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 188 VPS13_mid_rpt PF16910.3 NM_001018037.1_3 - 1.4e-80 270.0 15.6 2.9e-71 239.5 1.0 5.3 4 1 0 4 4 4 3 Repeating coiled region of VPS13 VPS13_C PF16909.3 NM_001018037.1_3 - 9.1e-67 224.1 7.0 4.2e-63 212.1 0.3 3.3 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.3 NM_001018037.1_3 - 2e-65 220.8 12.1 1.3e-63 214.8 4.1 4.6 5 0 0 5 5 5 2 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.5 NM_001018037.1_3 - 3.1e-36 123.9 1.4 1.3e-35 121.9 1.4 2.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.10 NM_001018037.1_3 - 1.4e-32 113.1 0.8 1.5e-31 109.6 0.2 2.6 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.9 NM_001018037.1_3 - 5.6e-14 52.1 0.2 5.7e-13 48.9 0.0 2.5 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF3482 PF11981.6 NM_001018037.1_3 - 0.29 10.4 1.6 0.61 9.3 1.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) COX4 PF02936.12 NM_001861.4_2 - 2.2e-58 196.0 2.4 2.8e-58 195.7 2.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF2228 PF10228.7 NM_017867.2_3 - 7.8e-114 379.5 0.2 9.5e-114 379.2 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2228) Peptidase_C70 PF12385.6 NM_017867.2_3 - 0.025 14.4 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 Papain-like cysteine protease AvrRpt2 Complex1_LYR PF05347.13 NM_001164840.2_2 - 8e-24 83.3 1.3 1.4e-23 82.5 1.3 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 NM_001164840.2_2 - 9.1e-08 32.6 0.6 1.4e-07 32.0 0.6 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.4 NM_001164840.2_2 - 0.00063 20.2 0.4 0.0012 19.3 0.4 1.5 1 0 0 1 1 1 1 Complex1_LYR-like RNase_H_2 PF13482.4 NM_001164840.2_2 - 0.17 11.8 0.5 0.4 10.5 0.0 1.7 2 0 0 2 2 2 0 RNase_H superfamily Collagen PF01391.16 NM_005202.3_3 - 4.9e-58 192.6 302.0 6.7e-07 28.8 27.1 10.8 2 1 6 8 8 8 5 Collagen triple helix repeat (20 copies) C1q PF00386.19 NM_005202.3_3 - 3.3e-37 127.4 0.1 4.3e-37 127.0 0.1 1.1 1 0 0 1 1 1 1 C1q domain MACPF PF01823.17 NM_199051.2_3 - 1.1e-07 32.1 0.6 2.6e-07 30.8 0.0 1.8 2 0 0 2 2 2 1 MAC/Perforin domain RPN7 PF10602.7 NM_212492.2_2 - 1.3e-73 246.3 0.8 2.1e-73 245.6 0.8 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.25 NM_212492.2_2 - 1.1e-16 61.1 0.7 2.5e-16 59.9 0.1 1.9 2 0 0 2 2 2 1 PCI domain TPR_11 PF13414.4 NM_212492.2_2 - 0.049 13.2 0.4 0.19 11.3 0.0 2.3 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.15 NM_212492.2_2 - 0.065 13.3 4.3 0.28 11.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 NM_212492.2_2 - 0.83 9.4 4.7 0.32 10.8 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat PID PF00640.21 NM_133173.2_3 - 2.7e-40 137.5 0.0 1.7e-35 121.9 0.0 2.2 2 0 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.24 NM_133173.2_3 - 9.3e-05 22.2 2.0 9.3e-05 22.2 2.0 2.1 2 0 0 2 2 2 1 WW domain PTB PF08416.11 NM_133173.2_3 - 0.095 12.7 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotyrosine-binding domain PKI PF02827.14 NM_006823.3_3 - 4.9e-27 93.8 0.9 7.2e-27 93.3 0.9 1.2 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor Rdx PF10262.7 NM_182704.1_2 - 7.7e-08 32.3 0.0 1.4e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Rdx family KRAB PF01352.25 NM_001305036.1_1 - 1.4e-25 88.5 0.2 2.6e-25 87.7 0.2 1.4 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 NM_001305036.1_3 - 2.5e-111 359.5 140.9 5.6e-09 35.9 2.2 18.2 18 0 0 18 18 18 17 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001305036.1_3 - 7.7e-80 259.0 169.2 7.1e-06 26.1 2.0 18.3 18 0 0 18 18 18 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001305036.1_3 - 2e-29 99.5 165.7 0.0067 17.0 1.5 18.8 19 0 0 19 19 19 16 C2H2-type zinc finger RVT_1 PF00078.25 NM_001305036.1_3 - 0.00074 19.0 0.1 0.0014 18.1 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) C1_4 PF07975.10 NM_001305036.1_3 - 0.0028 17.7 98.9 0.013 15.6 5.2 12.0 3 2 12 15 15 15 5 TFIIH C1-like domain zf-C2H2_6 PF13912.4 NM_001305036.1_3 - 0.0054 16.5 135.4 0.24 11.3 1.1 17.1 16 1 0 16 16 16 9 C2H2-type zinc finger BolA PF01722.16 NM_001305036.1_3 - 0.092 12.9 20.1 1 9.6 0.1 6.4 4 2 2 6 6 6 0 BolA-like protein Zn-ribbon_8 PF09723.8 NM_001305036.1_3 - 7.7 6.6 109.1 1.1 9.3 3.9 11.6 4 3 8 13 13 13 0 Zinc ribbon domain ARHGEF5_35 PF15441.4 NM_005435.3_2 - 4e-225 748.2 53.2 6.6e-225 747.5 53.2 1.4 1 0 0 1 1 1 1 Rho guanine nucleotide exchange factor 5/35 RhoGEF PF00621.18 NM_005435.3_2 - 2.4e-35 122.3 4.4 3.8e-35 121.6 4.4 1.3 1 0 0 1 1 1 1 RhoGEF domain SH3_9 PF14604.4 NM_005435.3_2 - 7.3e-12 44.8 0.1 1.4e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_005435.3_2 - 1.2e-09 37.5 0.0 2.6e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_005435.3_2 - 5.8e-08 32.2 0.0 1.5e-07 30.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 NM_005435.3_2 - 3.3e-05 24.2 0.0 8.3e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 PH domain RIBIOP_C PF04950.10 NM_018128.4_1 - 4e-130 433.4 0.1 6.2e-130 432.7 0.1 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.10 NM_018128.4_1 - 2.5e-21 75.4 0.0 4.8e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 AARP2CN (NUC121) domain EGF_CA PF07645.13 NM_001039349.2_2 - 3.4e-46 155.0 87.3 3.6e-13 49.4 6.3 7.9 8 0 0 8 8 8 6 Calcium-binding EGF domain cEGF PF12662.5 NM_001039349.2_2 - 9.4e-37 124.4 36.1 5.2e-09 35.8 0.6 6.9 6 0 0 6 6 6 6 Complement Clr-like EGF-like FXa_inhibition PF14670.4 NM_001039349.2_2 - 2.8e-09 37.0 76.4 2.6e-06 27.5 5.2 7.0 6 1 1 7 7 7 4 Coagulation Factor Xa inhibitory site EGF PF00008.25 NM_001039349.2_2 - 7.8e-05 22.8 79.2 0.0071 16.5 5.4 7.3 7 0 0 7 7 7 5 EGF-like domain EGF_3 PF12947.5 NM_001039349.2_2 - 0.00019 21.4 8.1 0.00019 21.4 8.1 7.0 6 2 1 7 7 7 4 EGF domain hEGF PF12661.5 NM_001039349.2_2 - 0.0016 18.9 1.4 0.0016 18.9 1.4 8.2 9 1 0 9 9 9 4 Human growth factor-like EGF Bax1-I PF01027.18 NM_001321427.1_1 - 9.4e-33 113.7 35.1 1.2e-32 113.3 35.1 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2371 PF10177.7 NM_001321427.1_1 - 0.05 13.6 0.5 0.087 12.9 0.5 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) GWT1 PF06423.10 NM_001321427.1_1 - 0.89 9.6 0.0 0.89 9.6 0.0 2.3 2 0 0 2 2 2 0 GWT1 Cbl_N PF02262.14 NM_001321807.1_2 - 2.3e-54 182.6 2.3 3.9e-54 181.8 2.3 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N3 PF02762.12 NM_001321807.1_2 - 4.2e-44 148.2 0.0 7.4e-44 147.4 0.0 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N2 PF02761.12 NM_001321807.1_2 - 6.5e-32 110.0 5.8 4.3e-31 107.3 1.5 2.5 2 0 0 2 2 2 1 CBL proto-oncogene N-terminus, EF hand-like domain Prok-RING_4 PF14447.4 NM_001321807.1_2 - 1e-12 47.6 9.0 3.1e-12 46.0 9.0 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 NM_001321807.1_2 - 1.7e-10 40.4 8.0 4.8e-10 39.0 8.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001321807.1_2 - 2.6e-08 33.4 7.4 8.1e-08 31.9 7.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001321807.1_2 - 5.4e-08 32.8 7.5 1.9e-07 31.1 7.5 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_001321807.1_2 - 0.00036 20.2 8.0 0.00036 20.2 8.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001321807.1_2 - 0.017 14.9 10.0 0.051 13.4 10.0 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_001321807.1_2 - 0.019 14.8 8.8 0.07 13.0 8.8 2.1 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.4 NM_001321807.1_2 - 0.07 13.2 8.0 0.27 11.3 8.0 2.1 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.4 NM_001321807.1_2 - 0.24 11.0 10.2 0.71 9.5 10.2 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain OATP PF03137.18 NM_001145945.1_2 - 3.6e-157 523.8 14.1 1.9e-119 399.3 6.7 2.4 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 NM_001145945.1_2 - 9.3e-19 67.4 8.7 5.7e-12 45.1 1.4 3.2 3 0 0 3 3 3 3 Major Facilitator Superfamily Kazal_2 PF07648.13 NM_001145945.1_2 - 9.5e-11 41.6 4.2 2.9e-10 40.0 4.2 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 NM_001145945.1_2 - 0.012 15.4 8.9 0.052 13.4 8.9 2.1 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain DUF202 PF02656.13 NM_001145945.1_2 - 1.2 9.4 9.1 9.4 6.6 0.1 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF202) Thioredoxin_8 PF13905.4 NM_145283.2_2 - 3.4e-16 59.2 0.0 6.3e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like 7tm_4 PF13853.4 NM_001004728.1_1 - 5.4e-53 180.4 9.5 6.7e-53 180.1 9.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004728.1_1 - 1.1e-18 67.3 14.1 2.3e-18 66.3 14.1 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) BTD PF09270.8 NM_015874.4_1 - 4.5e-74 247.6 0.0 7e-74 247.0 0.0 1.3 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.9 NM_015874.4_1 - 2.8e-50 170.8 0.9 2.8e-50 170.8 0.9 1.8 2 0 0 2 2 2 1 LAG1, DNA binding TIG PF01833.22 NM_015874.4_1 - 0.003 17.5 0.0 0.0082 16.1 0.0 1.7 1 0 0 1 1 1 1 IPT/TIG domain GBP PF02263.17 NM_198460.2_2 - 7.2e-121 402.2 0.0 7.2e-121 402.2 0.0 2.1 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 NM_198460.2_2 - 3.1e-120 401.0 27.5 4e-120 400.6 27.5 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain RHD3 PF05879.10 NM_198460.2_2 - 0.00066 17.8 7.1 0.0012 17.0 0.0 2.3 2 0 0 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) PBP_sp32 PF07222.10 NM_198460.2_2 - 0.018 14.4 11.6 0.035 13.4 11.6 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 MMR_HSR1 PF01926.21 NM_198460.2_2 - 0.059 13.3 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase CorA PF01544.16 NM_198460.2_2 - 8.8 5.4 7.7 19 4.3 7.7 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein zf-C2H2 PF00096.24 NM_001270942.1_1 - 3.5e-07 30.2 22.1 0.00056 20.1 8.7 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001270942.1_1 - 0.00014 22.3 13.3 0.12 13.2 6.1 4.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_001270942.1_1 - 0.00032 20.9 6.6 0.00032 20.9 6.6 4.4 4 0 0 4 4 4 1 Zinc-finger double domain Methyltransf_25 PF13649.4 NM_001318865.1_3 - 8.9e-11 42.2 0.0 1.7e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001318865.1_3 - 2.5e-08 33.7 0.0 3.4e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_001318865.1_3 - 1.6e-07 31.8 0.0 2.7e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 NM_001318865.1_3 - 1.3e-05 25.1 0.0 1.9e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001318865.1_3 - 1.7e-05 25.2 0.0 3.1e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.12 NM_001318865.1_3 - 0.00092 18.5 0.0 0.003 16.9 0.0 1.7 2 0 0 2 2 2 1 Tellurite resistance protein TehB Ubie_methyltran PF01209.16 NM_001318865.1_3 - 0.0057 15.9 0.0 0.0084 15.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 NM_001318865.1_3 - 0.0091 15.4 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.17 NM_001318865.1_3 - 0.093 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPMT PF05724.9 NM_001318865.1_3 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) UPAR_LY6 PF00021.19 NM_001160354.1_1 - 0.095 13.3 1.9 0.19 12.3 1.9 1.5 1 0 0 1 1 1 0 u-PAR/Ly-6 domain WD40 PF00400.30 NM_001178003.1_2 - 2.7e-16 59.5 8.2 1.6e-05 25.4 0.3 8.0 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001178003.1_2 - 0.00027 21.0 0.0 0.0086 16.2 0.0 3.1 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain RAI16-like PF10257.7 NM_020940.3_3 - 3.3e-139 463.6 4.9 4.3e-139 463.2 4.9 1.1 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein SUV3_C PF12513.6 NM_001323587.1_2 - 6e-17 61.2 0.1 1.2e-16 60.2 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.29 NM_001323587.1_2 - 4.8e-11 42.9 0.0 1.3e-10 41.5 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain L27_2 PF09045.8 NM_001323587.1_2 - 0.088 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 L27_2 Cation_efflux PF01545.19 NM_013309.5_1 - 1.3e-53 181.6 14.9 2.3e-53 180.8 14.9 1.4 1 0 0 1 1 1 1 Cation efflux family RNA_pol_Rpb2_6 PF00562.26 NM_019014.5_2 - 2.5e-117 392.1 0.0 5.1e-117 391.1 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.13 NM_019014.5_2 - 3.3e-34 118.1 0.0 4.7e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.14 NM_019014.5_2 - 2.1e-27 94.9 0.0 3.9e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.18 NM_019014.5_2 - 5.9e-22 77.8 0.0 1.2e-21 76.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.10 NM_019014.5_2 - 2.7e-19 68.8 0.0 5.1e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.12 NM_019014.5_2 - 1.6e-12 47.4 0.0 2.3e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 DUF1186 PF06685.9 NM_019014.5_2 - 0.05 12.8 0.0 0.088 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) Med12-LCEWAV PF12145.6 NM_053002.5_1 - 3e-183 609.8 0.2 6.1e-183 608.9 0.2 1.5 1 0 0 1 1 1 1 Eukaryotic Mediator 12 subunit domain Med12-PQL PF12144.6 NM_053002.5_1 - 1.7e-53 181.5 44.2 1.7e-53 181.5 44.2 3.0 3 0 0 3 3 3 1 Eukaryotic Mediator 12 catenin-binding domain Med12 PF09497.8 NM_053002.5_1 - 1.8e-14 53.6 0.1 4e-14 52.5 0.1 1.5 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Myosin_tail_1 PF01576.17 NM_001256095.1_2 - 0 1703.2 316.3 0 1702.9 316.3 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 NM_001256095.1_2 - 0 1023.2 0.7 0 1023.2 0.7 2.9 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_N PF02736.17 NM_001256095.1_2 - 1.3e-12 47.1 0.1 3.3e-12 45.9 0.1 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 NM_001256095.1_2 - 0.00011 21.6 0.2 0.00039 19.8 0.2 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif ADIP PF11559.6 NM_001256095.1_2 - 0.00013 22.0 21.1 0.00013 22.0 21.1 14.6 1 1 14 15 15 15 4 Afadin- and alpha -actinin-Binding AAA_22 PF13401.4 NM_001256095.1_2 - 0.083 13.0 0.0 0.083 13.0 0.0 5.8 5 1 1 6 6 6 0 AAA domain Ly49 PF08391.8 NM_197948.2_2 - 1.1e-06 28.9 0.0 2.2e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Fucokinase PF07959.10 NM_001199329.2_1 - 7.6e-37 127.2 0.9 1.1e-36 126.6 0.9 1.1 1 0 0 1 1 1 1 L-fucokinase Hexapep PF00132.22 NM_001199329.2_1 - 0.035 13.7 0.8 0.098 12.3 0.2 2.1 2 1 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) PDZ PF00595.22 NM_004513.5_1 - 2.5e-22 78.9 0.5 1.9e-11 44.0 0.2 2.4 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_004513.5_1 - 8.5e-07 29.1 0.0 0.037 14.2 0.0 2.4 2 0 0 2 2 2 2 PDZ domain BNIP2 PF12496.6 NM_001308051.1_2 - 3.1e-40 137.6 3.0 5.3e-40 136.9 3.0 1.3 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 NM_001308051.1_2 - 4e-31 107.8 0.2 8.6e-31 106.8 0.2 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 NM_001308051.1_2 - 8e-08 32.0 0.2 1.7e-07 31.0 0.2 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain DUF3504 PF12012.6 NM_001320585.1_1 - 1.6e-61 206.8 0.7 1.6e-61 206.8 0.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3504) CARD PF00619.19 NM_001320585.1_1 - 0.0057 16.5 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Caspase recruitment domain Cyclin PF08613.9 NM_001321390.1_2 - 9.6e-06 25.9 0.0 1.5e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.21 NM_001321390.1_2 - 0.012 15.3 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Pkinase_Tyr PF07714.15 NM_001256794.1_2 - 3.6e-36 124.7 0.0 4.7e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001256794.1_2 - 3.5e-35 121.5 0.0 5.1e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 NM_001256794.1_2 - 4.6e-15 54.7 0.9 9.4e-15 53.7 0.9 1.6 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 NM_001256794.1_2 - 1.2e-12 48.6 10.7 3.2e-12 47.2 10.7 1.8 1 0 0 1 1 1 1 Activin types I and II receptor domain FTA2 PF13095.4 NM_001256794.1_2 - 0.044 13.3 0.0 0.072 12.6 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Med24_N PF11277.6 NM_001267797.1_2 - 0 1280.1 10.9 0 1279.4 10.9 1.3 1 0 0 1 1 1 1 Mediator complex subunit 24 N-terminal DUF4752 PF15944.3 NM_001267797.1_2 - 0.13 12.2 0.0 14 5.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4752) LRR_8 PF13855.4 NM_032229.2_1 - 2.1e-44 149.0 40.6 1.5e-16 59.7 4.3 6.6 2 2 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.5 NM_032229.2_1 - 2.7e-20 71.9 37.6 3.7e-06 27.0 0.7 7.9 4 1 3 7 7 7 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_032229.2_1 - 6.4e-06 25.6 16.3 0.0097 15.3 0.3 4.2 2 2 2 4 4 4 2 Leucine-rich repeat TPKR_C2 PF16920.3 NM_032229.2_1 - 0.0068 16.4 3.8 0.022 14.7 0.4 3.0 3 0 0 3 3 3 1 Tyrosine-protein kinase receptor C2 Ig-like domain LRR_1 PF00560.31 NM_032229.2_1 - 0.033 14.5 39.2 2.9 8.6 0.2 11.2 13 1 0 13 13 13 0 Leucine Rich Repeat DUF1049 PF06305.9 NM_032229.2_1 - 0.073 12.8 0.1 0.19 11.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) 7tm_4 PF13853.4 NM_001004463.1_1 - 1e-57 195.9 15.6 1.3e-57 195.6 15.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004463.1_1 - 1.5e-21 76.7 18.8 4e-21 75.3 19.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001004463.1_1 - 0.0011 18.2 16.6 0.0034 16.7 16.6 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx A_deaminase PF00962.20 NM_000022.3_2 - 2.8e-106 355.4 0.0 3.3e-106 355.2 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase TPR_2 PF07719.15 NM_001317037.1_2 - 2.2e-23 80.3 21.7 2.4e-05 24.0 0.2 9.8 9 1 1 10 10 10 5 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001317037.1_2 - 1e-22 78.8 16.4 1.1e-06 28.0 0.3 8.6 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001317037.1_2 - 8.8e-14 50.8 7.2 1.8e-05 24.2 0.1 8.1 6 2 2 8 8 8 3 TPR repeat TPR_16 PF13432.4 NM_001317037.1_2 - 2.8e-13 50.2 15.5 0.00056 20.4 1.1 6.3 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001317037.1_2 - 1.8e-09 37.6 22.9 2.6e-05 24.3 0.4 7.5 4 3 3 8 8 8 4 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001317037.1_2 - 1.2e-07 31.6 20.2 0.0069 16.4 0.4 6.5 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001317037.1_2 - 1.4e-07 31.6 18.4 1.7 9.5 0.1 8.5 6 3 3 9 9 8 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001317037.1_2 - 2.8e-07 30.0 3.7 0.18 11.8 0.1 4.7 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001317037.1_2 - 4.8e-07 29.4 1.6 0.01 15.9 0.0 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001317037.1_2 - 8.1e-06 26.1 28.4 0.18 12.2 0.1 7.2 5 1 2 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001317037.1_2 - 0.00081 19.5 2.3 35 4.9 0.0 5.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TnpB_IS66 PF05717.11 NM_001317037.1_2 - 0.0029 17.3 0.4 5.8 6.8 0.0 3.5 3 0 0 3 3 3 1 IS66 Orf2 like protein TPR_10 PF13374.4 NM_001317037.1_2 - 0.0032 17.2 4.7 9.7 6.1 0.0 5.1 3 1 1 4 4 4 1 Tetratricopeptide repeat DUF717 PF05338.10 NM_001317037.1_2 - 0.027 14.5 1.0 0.089 12.8 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF717) TPR_21 PF09976.7 NM_001317037.1_2 - 0.095 12.3 6.1 0.2 11.3 0.3 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain ANAPC3 PF12895.5 NM_001317037.1_2 - 0.24 11.5 27.8 0.1 12.6 9.5 4.8 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Sacchrp_dh_NADP PF03435.16 NM_001319193.1_3 - 0.97 9.6 2.9 50 4.0 0.3 3.1 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Sua5_yciO_yrdC PF01300.16 NM_024640.3_2 - 3.4e-43 147.1 0.0 4.4e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 Telomere recombination Integrin_beta PF00362.16 NM_001005731.2_2 - 2.9e-104 348.0 0.0 4.4e-104 347.4 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain fn3 PF00041.19 NM_001005731.2_2 - 5e-73 241.4 0.6 1.4e-18 66.8 0.1 4.6 4 0 0 4 4 4 4 Fibronectin type III domain Calx-beta PF03160.12 NM_001005731.2_2 - 4e-24 84.6 0.0 1.3e-23 82.9 0.0 2.0 1 0 0 1 1 1 1 Calx-beta domain Integrin_B_tail PF07965.10 NM_001005731.2_2 - 8.7e-18 64.5 6.4 8.7e-18 64.5 6.4 3.1 3 0 0 3 3 3 1 Integrin beta tail domain PSI_integrin PF17205.1 NM_001005731.2_2 - 4.3e-10 39.1 9.4 4.3e-10 39.1 9.4 3.9 3 1 0 3 3 3 1 Integrin plexin domain Pur_ac_phosph_N PF16656.3 NM_001005731.2_2 - 3.5e-07 30.6 0.0 0.1 13.1 0.0 5.2 4 1 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.11 NM_001005731.2_2 - 8.4e-07 29.1 85.2 9e-05 22.6 9.6 5.3 5 0 0 5 5 5 4 EGF-like domain SEA PF01390.18 NM_001005731.2_2 - 0.016 15.4 0.0 0.043 14.0 0.0 1.8 1 0 0 1 1 1 0 SEA domain GAS2 PF02187.15 NM_001303130.1_3 - 4.6e-26 90.6 0.0 8e-26 89.8 0.0 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.29 NM_001303130.1_3 - 8.7e-11 41.9 0.0 1.4e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Tim17 PF02466.17 NM_175614.4_3 - 2.1e-06 27.9 2.3 3.6e-06 27.1 2.3 1.5 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family AlbA_2 PF04326.12 NM_152270.3_2 - 1.2e-14 54.6 0.0 2.7e-11 43.7 0.0 2.4 2 0 0 2 2 2 2 Putative DNA-binding domain DUF2075 PF09848.7 NM_152270.3_2 - 8.5e-05 21.8 0.0 0.00022 20.4 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.13 NM_152270.3_2 - 0.0032 17.4 0.0 0.0059 16.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.4 NM_152270.3_2 - 0.0068 16.5 0.1 0.34 11.0 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.4 NM_152270.3_2 - 0.0076 15.9 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.4 NM_152270.3_2 - 0.014 15.3 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain UvrD_C_2 PF13538.4 NM_152270.3_2 - 0.015 14.9 0.0 0.03 14.0 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain NACHT PF05729.10 NM_152270.3_2 - 0.038 13.8 0.0 0.13 12.0 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.4 NM_152270.3_2 - 0.066 13.4 0.0 0.31 11.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.4 NM_152270.3_2 - 0.1 12.8 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.14 NM_152270.3_2 - 0.12 11.7 0.1 2.3 7.5 0.0 2.2 1 1 1 2 2 2 0 PhoH-like protein AAA PF00004.27 NM_152270.3_2 - 0.14 12.5 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.4 NM_152270.3_2 - 0.14 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain PDZ PF00595.22 NM_001199784.1_3 - 1.3e-15 57.4 3.8 5.5e-09 36.1 0.0 2.7 3 0 0 3 3 3 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001199784.1_3 - 8.9e-10 38.6 0.5 1.3e-05 25.3 0.0 2.4 1 1 1 2 2 2 2 PDZ domain Oxygenase-NA PF09859.7 NM_001199784.1_3 - 0.22 10.9 0.6 0.44 10.0 0.3 1.5 2 0 0 2 2 2 0 Oxygenase, catalysing oxidative methylation of damaged DNA TANGO2 PF05742.10 NM_001322175.1_2 - 6.2e-23 82.0 0.0 8.9e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Transport and Golgi organisation 2 TANGO2 PF05742.10 NM_001322175.1_3 - 1.1e-30 107.4 0.0 1.5e-30 106.9 0.0 1.1 1 0 0 1 1 1 1 Transport and Golgi organisation 2 zf-H2C2_2 PF13465.4 NM_152289.2_2 - 8.3e-60 196.6 70.1 4.1e-08 33.2 0.4 12.5 13 0 0 13 13 12 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_152289.2_2 - 6.6e-43 142.7 65.2 2.7e-05 24.3 0.6 12.0 11 0 0 11 11 11 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_152289.2_2 - 1.7e-29 99.8 63.2 0.0039 17.8 2.1 11.8 11 0 0 11 11 11 9 C2H2-type zinc finger KRAB PF01352.25 NM_152289.2_2 - 6.1e-22 76.9 1.2 1e-21 76.2 1.2 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_152289.2_2 - 4.5e-12 45.5 63.2 0.0019 17.9 0.2 10.7 11 0 0 11 11 11 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_152289.2_2 - 2.5e-06 27.5 39.7 0.032 14.4 0.2 8.5 9 0 0 9 9 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_152289.2_2 - 0.00021 20.8 46.8 0.0074 15.9 0.3 9.1 9 0 0 9 9 8 3 zinc-finger C2H2-type Trm112p PF03966.14 NM_152289.2_2 - 0.0037 17.7 2.6 4.7 7.7 0.1 4.1 2 1 0 2 2 2 1 Trm112p-like protein C1_1 PF00130.20 NM_152289.2_2 - 0.0053 16.5 30.0 0.25 11.1 0.4 7.0 3 1 4 8 8 8 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.8 NM_152289.2_2 - 0.024 14.6 46.1 0.37 10.8 3.9 7.8 5 1 4 9 9 9 0 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_152289.2_2 - 0.05 14.2 36.0 0.86 10.3 1.6 6.2 2 2 3 6 6 6 0 zinc-ribbon family DUF3268 PF11672.6 NM_152289.2_2 - 0.061 13.5 21.9 0.27 11.4 0.1 5.0 4 1 0 5 5 5 0 zinc-finger-containing domain XPA_N PF01286.16 NM_152289.2_2 - 0.28 11.1 44.4 4.1 7.4 0.1 9.7 10 0 0 10 10 10 0 XPA protein N-terminal zf-trcl PF13451.4 NM_152289.2_2 - 0.58 10.0 34.7 12 5.7 0.0 8.7 9 0 0 9 9 9 0 Probable zinc-ribbon domain ADK_lid PF05191.12 NM_152289.2_2 - 3.2 7.7 27.9 19 5.2 2.8 6.7 6 1 2 8 8 8 0 Adenylate kinase, active site lid Pkinase_Tyr PF07714.15 NM_001291980.1_3 - 1.6e-100 335.6 0.0 2e-100 335.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001291980.1_3 - 7.4e-43 146.7 0.0 1e-42 146.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.4 NM_001291980.1_3 - 6.5e-33 113.1 0.0 2.3e-13 50.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_001291980.1_3 - 4e-31 106.8 0.0 9.4e-14 51.1 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001291980.1_3 - 2.1e-22 79.1 0.0 7.8e-10 38.8 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_001291980.1_3 - 1.5e-18 66.6 0.0 3.2e-09 36.7 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 NM_001291980.1_3 - 1.5e-14 54.0 0.4 0.0019 18.2 0.1 5.9 3 3 1 4 4 4 3 Immunoglobulin V-set domain APH PF01636.21 NM_001291980.1_3 - 0.0015 18.3 0.0 1.2 8.8 0.0 3.3 3 0 0 3 3 3 1 Phosphotransferase enzyme family C2-set_2 PF08205.10 NM_001291980.1_3 - 0.019 14.9 0.0 0.11 12.5 0.0 2.3 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 NM_001291980.1_3 - 0.038 13.9 0.0 14 5.7 0.0 2.9 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Kinase-like PF14531.4 NM_001291980.1_3 - 0.068 12.3 0.0 0.17 11.0 0.0 1.6 2 0 0 2 2 2 0 Kinase-like DDE_Tnp_1_7 PF13843.4 NM_032507.3_1 - 2.2e-103 346.1 0.1 3.2e-103 345.6 0.1 1.2 1 0 0 1 1 1 1 Transposase IS4 SCAN PF02023.15 NM_032507.3_1 - 1.1e-38 130.7 1.7 2.3e-38 129.7 1.7 1.6 1 0 0 1 1 1 1 SCAN domain Staufen_C PF16482.3 NM_001322932.1_1 - 2e-53 179.1 0.1 3e-50 168.9 0.0 3.7 4 0 0 4 4 4 1 Staufen C-terminal domain dsrm PF00035.24 NM_001322932.1_1 - 2.2e-30 105.0 0.6 8.8e-12 45.4 0.1 3.8 3 0 0 3 3 3 3 Double-stranded RNA binding motif DND1_DSRM PF14709.5 NM_001322932.1_1 - 0.0011 19.0 0.2 0.048 13.8 0.0 3.2 3 0 0 3 3 3 1 double strand RNA binding domain from DEAD END PROTEIN 1 Sema PF01403.17 NM_006378.3_3 - 2.9e-150 500.6 0.1 1e-149 498.8 0.0 1.7 2 0 0 2 2 2 1 Sema domain ig PF00047.23 NM_006378.3_3 - 1.3e-07 31.6 0.0 2.9e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 NM_006378.3_3 - 2.9e-07 30.8 3.0 1.1e-06 28.9 3.0 2.1 1 0 0 1 1 1 1 Plexin repeat Ig_3 PF13927.4 NM_006378.3_3 - 0.0011 19.3 0.3 0.0054 17.2 0.0 2.3 3 0 0 3 3 3 1 Immunoglobulin domain Ig_5 PF16681.3 NM_006378.3_3 - 0.0072 16.6 0.0 0.022 15.0 0.0 1.8 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.4 NM_006378.3_3 - 0.0089 16.2 0.0 0.025 14.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain DUF3891 PF13030.4 NM_006378.3_3 - 0.036 13.7 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3891) V-set PF07686.15 NM_006378.3_3 - 0.053 13.6 0.2 2.1 8.4 0.0 2.4 1 1 1 2 2 2 0 Immunoglobulin V-set domain zf-H2C2_2 PF13465.4 NM_032825.4_2 - 2.9e-51 169.6 73.8 3.5e-08 33.4 3.5 12.6 13 0 0 13 13 12 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_032825.4_2 - 7e-46 152.1 79.1 2.9e-06 27.3 1.1 11.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_032825.4_2 - 2.1e-29 99.5 70.6 0.00046 20.6 0.5 11.5 11 0 0 11 11 10 9 C2H2-type zinc finger KRAB PF01352.25 NM_032825.4_2 - 6.5e-25 86.4 0.4 6.5e-25 86.4 0.4 1.6 2 0 0 2 2 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_032825.4_2 - 1.4e-10 41.0 37.3 0.0015 18.5 1.1 6.1 5 1 1 6 6 6 4 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_032825.4_2 - 6.7e-10 38.5 58.5 0.069 13.0 0.2 10.9 10 0 0 10 10 10 7 C2H2-type zinc finger DUF3268 PF11672.6 NM_032825.4_2 - 7.4e-07 29.4 26.6 0.035 14.3 0.5 5.2 4 1 1 5 5 5 4 zinc-finger-containing domain zinc_ribbon_9 PF14369.4 NM_032825.4_2 - 0.00022 21.3 24.7 5.3 7.3 0.7 8.5 8 0 0 8 8 8 1 zinc-ribbon Zn_Tnp_IS1595 PF12760.5 NM_032825.4_2 - 0.0035 17.1 43.8 0.038 13.8 4.5 5.6 4 2 2 6 6 6 3 Transposase zinc-ribbon domain zf-Di19 PF05605.10 NM_032825.4_2 - 0.0059 16.7 2.0 0.0059 16.7 2.0 5.9 2 1 4 6 6 6 2 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.3 NM_032825.4_2 - 0.0074 16.9 36.0 1.3 9.7 1.2 5.4 1 1 3 4 4 4 2 zinc-ribbon family GATA PF00320.25 NM_032825.4_2 - 0.019 14.5 30.5 0.83 9.2 0.1 7.5 5 1 2 7 7 7 0 GATA zinc finger zf-LYAR PF08790.9 NM_032825.4_2 - 0.024 14.4 0.6 0.024 14.4 0.6 8.9 9 0 0 9 9 9 0 LYAR-type C2HC zinc finger FYDLN_acid PF09538.8 NM_032825.4_2 - 0.024 15.2 20.4 6.2 7.4 0.0 7.6 1 1 6 7 7 7 0 Protein of unknown function (FYDLN_acid) zf-C4_ClpX PF06689.11 NM_032825.4_2 - 0.045 13.5 0.2 0.045 13.5 0.2 5.1 5 0 0 5 5 5 0 ClpX C4-type zinc finger C1_4 PF07975.10 NM_032825.4_2 - 0.36 11.0 39.1 0.42 10.8 3.5 6.6 3 2 3 7 7 7 0 TFIIH C1-like domain DNA_ligase_ZBD PF03119.14 NM_032825.4_2 - 1 9.3 7.1 16 5.5 0.5 3.6 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain CpXC PF14353.4 NM_032825.4_2 - 1.1 9.1 37.6 6.4 6.7 0.7 8.7 2 1 2 6 6 6 0 CpXC protein zf-AN1 PF01428.14 NM_032825.4_2 - 1.5 8.9 47.9 0.24 11.5 0.7 9.6 8 1 1 9 9 9 0 AN1-like Zinc finger ADK_lid PF05191.12 NM_032825.4_2 - 6.8 6.7 28.9 0.77 9.7 0.3 6.2 3 2 2 6 6 6 0 Adenylate kinase, active site lid SGL PF08450.10 NM_001282848.1_3 - 4.1e-76 255.7 0.1 5.8e-76 255.2 0.1 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.19 NM_001282848.1_3 - 0.098 12.6 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 NHL repeat Reg_prop PF07494.9 NM_001282848.1_3 - 0.14 12.3 0.0 0.49 10.7 0.0 2.0 1 0 0 1 1 1 0 Two component regulator propeller BTB PF00651.29 NM_003563.3_3 - 8.7e-33 112.7 1.3 2e-32 111.5 0.3 1.9 1 1 1 2 2 2 1 BTB/POZ domain MATH PF00917.24 NM_003563.3_3 - 4.3e-06 26.7 0.0 1.3e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 MATH domain BACK PF07707.13 NM_003563.3_3 - 0.019 14.9 0.2 0.39 10.7 0.0 2.7 3 0 0 3 3 3 0 BTB And C-terminal Kelch Ras PF00071.20 NM_001256411.1_2 - 1.4e-44 151.4 0.0 2.1e-44 150.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001256411.1_2 - 5.5e-35 120.1 0.0 8.3e-35 119.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001256411.1_2 - 5.5e-14 51.9 0.2 8.9e-14 51.2 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001256411.1_2 - 1.1e-05 25.3 0.1 1.7e-05 24.8 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_001256411.1_2 - 0.0028 16.9 0.0 0.0041 16.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 NM_001256411.1_2 - 0.029 13.7 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.25 NM_001256411.1_2 - 0.031 13.7 0.1 0.068 12.6 0.1 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.4 NM_001256411.1_2 - 0.051 13.1 0.0 0.076 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.14 NM_001256411.1_2 - 0.055 13.2 0.0 0.097 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.4 NM_001256411.1_2 - 0.11 12.8 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 NM_001256411.1_2 - 0.12 12.6 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 NM_001256411.1_2 - 0.18 11.4 0.1 0.38 10.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TRPM_tetra PF16519.3 NM_206944.3_2 - 4.6e-24 84.1 5.4 1.1e-23 82.9 5.4 1.7 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.29 NM_206944.3_2 - 5e-18 65.1 17.7 7.6e-18 64.5 17.7 1.2 1 0 0 1 1 1 1 Ion transport protein DUF3552 PF12072.6 NM_206944.3_2 - 0.027 13.8 4.3 0.07 12.4 4.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Reo_sigmaC PF04582.10 NM_206944.3_2 - 0.078 12.2 0.4 0.15 11.3 0.4 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein G-gamma PF00631.20 NM_001098722.1_2 - 4.7e-14 52.0 0.1 9.1e-14 51.1 0.1 1.5 1 0 0 1 1 1 1 GGL domain Arfaptin PF06456.11 NM_004968.3_1 - 2.4e-91 305.3 10.3 3.4e-91 304.7 10.3 1.2 1 0 0 1 1 1 1 Arfaptin-like domain ICA69 PF04629.12 NM_004968.3_1 - 3e-61 207.8 15.1 5.3e-43 148.0 5.8 2.4 1 1 1 2 2 2 2 Islet cell autoantigen ICA69, C-terminal domain Prion PF00377.16 NM_000311.3_1 - 1.1e-34 118.6 2.4 1.7e-34 118.0 2.4 1.3 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 NM_000311.3_1 - 7.3e-17 60.8 4.0 1.6e-16 59.7 4.0 1.6 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal zf-H2C2_2 PF13465.4 NM_001001668.3_2 - 1.2e-129 417.3 142.1 7.4e-09 35.5 1.3 19.7 19 0 0 19 19 19 17 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001001668.3_2 - 4.3e-68 222.0 151.6 2.8e-05 24.2 0.6 19.6 19 0 0 19 19 19 17 Zinc finger, C2H2 type KRAB PF01352.25 NM_001001668.3_2 - 4.4e-23 80.5 0.5 8.2e-23 79.7 0.5 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001001668.3_2 - 2.2e-21 74.5 160.6 0.05 14.3 1.9 19.9 20 0 0 20 20 20 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001001668.3_2 - 4.2e-08 32.8 121.9 0.21 11.4 0.7 18.6 19 1 0 19 19 19 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001001668.3_2 - 7.1e-07 29.1 88.5 0.27 11.2 5.5 11.7 3 2 13 17 17 17 11 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001001668.3_2 - 0.00028 21.0 81.3 2.4 8.4 0.0 17.4 18 0 0 18 18 18 4 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001001668.3_2 - 0.4 10.6 84.1 0.79 9.7 0.0 16.2 17 0 0 17 17 17 0 XPA protein N-terminal zf-LYAR PF08790.9 NM_001001668.3_2 - 8.7 6.2 82.5 0.56 10.0 0.0 14.9 17 0 0 17 17 17 0 LYAR-type C2HC zinc finger zinc_ribbon_15 PF17032.3 NM_001001668.3_2 - 9.7 6.9 67.8 2.8 8.6 3.2 9.1 1 1 6 9 9 9 0 zinc-ribbon family DUF2482 PF10655.7 NM_001001668.3_3 - 0.054 13.7 1.2 16 5.8 0.1 3.2 3 0 0 3 3 3 0 Hypothetical protein of unknown function (DUF2482) DUF3402 PF11882.6 NM_001270768.1_2 - 6.4e-103 345.2 26.5 6.9e-67 226.4 4.7 3.4 2 1 2 4 4 4 3 Domain of unknown function (DUF3402) N1221 PF07923.11 NM_001270768.1_2 - 5.1e-52 176.7 0.0 8.5e-52 176.0 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein ELM2 PF01448.22 NM_001270768.1_2 - 0.095 13.4 0.5 0.23 12.1 0.5 1.6 1 0 0 1 1 1 0 ELM2 domain Alk_phosphatase PF00245.18 NM_001632.4_3 - 1.3e-186 620.4 0.0 1.5e-186 620.2 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Cystatin PF00031.19 NM_001622.2_1 - 7.9e-24 83.6 0.0 7.3e-19 67.7 0.0 2.3 2 0 0 2 2 2 2 Cystatin domain Cathelicidins PF00666.15 NM_001622.2_1 - 0.11 12.7 0.9 0.41 10.8 0.1 2.1 2 1 0 2 2 2 0 Cathelicidin Ribosomal_S8e PF01201.20 NM_001271665.1_1 - 3.6e-05 23.8 0.0 5.3e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e Ribosomal_S8e PF01201.20 NM_001271665.1_2 - 0.00039 20.4 23.5 0.004 17.2 23.5 2.3 1 1 0 1 1 1 1 Ribosomal protein S8e PAS_3 PF08447.10 NM_001243084.1_2 - 9.4e-28 96.2 0.2 2.7e-21 75.5 0.1 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 NM_001243084.1_2 - 3e-22 78.7 0.9 1.2e-19 70.3 0.1 2.4 2 0 0 2 2 2 2 PAS domain HIF-1a_CTAD PF08778.8 NM_001243084.1_2 - 5.2e-22 77.0 0.5 9.8e-22 76.2 0.5 1.5 1 0 0 1 1 1 1 HIF-1 alpha C terminal transactivation domain HIF-1 PF11413.6 NM_001243084.1_2 - 2.2e-15 55.6 6.3 4.5e-15 54.6 6.3 1.5 1 0 0 1 1 1 1 Hypoxia-inducible factor-1 PAS PF00989.23 NM_001243084.1_2 - 3.9e-15 55.7 0.0 6e-07 29.3 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.5 NM_001243084.1_2 - 1.9e-09 37.6 0.0 0.00098 19.2 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 NM_001243084.1_2 - 6.9e-07 29.4 0.0 0.014 15.5 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 NM_001243084.1_2 - 0.051 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Spt20 PF12090.6 NM_001014286.2_3 - 6.9e-34 117.3 0.6 8.9e-20 71.2 0.0 5.1 5 1 1 6 6 6 3 Spt20 family WD40 PF00400.30 NM_004814.2_2 - 9.7e-50 165.4 6.7 1.5e-06 28.7 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_004814.2_2 - 5.1e-14 52.2 0.1 0.0039 17.3 0.0 5.6 3 3 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_004814.2_2 - 1.9e-07 31.0 0.2 0.035 13.8 0.1 3.1 2 1 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 NM_004814.2_2 - 3.3e-05 22.9 0.1 3.8 6.3 0.0 4.4 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.14 NM_004814.2_2 - 0.0017 16.8 0.1 0.6 8.4 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.6 NM_004814.2_2 - 0.018 13.6 5.2 6 5.2 0.0 4.0 1 1 3 4 4 4 0 Nucleoporin Nup120/160 WD40_like PF17005.3 NM_004814.2_2 - 0.021 14.0 0.0 0.88 8.7 0.0 2.4 2 1 0 2 2 2 0 WD40-like domain SPRY PF00622.26 NM_001271942.1_1 - 2.4e-09 37.2 0.0 9.3e-09 35.3 0.0 2.0 2 0 0 2 2 2 1 SPRY domain zf-C3HC4_4 PF15227.4 NM_001271942.1_1 - 8.7e-07 28.9 18.9 8.7e-07 28.9 18.9 3.1 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 NM_001271942.1_1 - 2.4e-05 23.9 17.9 2.4e-05 23.9 17.9 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001271942.1_1 - 0.00012 21.7 14.8 0.00012 21.7 14.8 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001271942.1_1 - 0.00017 21.3 18.9 0.00052 19.7 18.9 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001271942.1_1 - 0.0011 19.0 18.9 0.0011 19.0 18.9 2.7 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.4 NM_001271942.1_1 - 0.0012 18.7 13.3 0.0012 18.7 13.3 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_6 PF14835.4 NM_001271942.1_1 - 0.015 15.1 11.3 0.048 13.4 11.3 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Baculo_IE-1 PF05290.9 NM_001271942.1_1 - 0.34 10.7 13.2 0.95 9.3 13.2 1.7 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Vinculin PF01044.17 NM_001323987.1_1 - 2.2e-211 704.6 23.4 2.8e-211 704.3 23.4 1.0 1 0 0 1 1 1 1 Vinculin family IMS PF00817.18 NM_001323987.1_1 - 0.38 10.6 4.0 13 5.6 3.9 2.6 1 1 0 1 1 1 0 impB/mucB/samB family DivIC PF04977.13 NM_001323987.1_1 - 8.4 6.1 7.9 0.51 10.0 0.4 2.8 3 0 0 3 3 3 0 Septum formation initiator Nnf1 PF03980.12 NM_001199662.1_2 - 2e-22 79.5 0.9 3.7e-22 78.7 0.9 1.4 1 0 0 1 1 1 1 Nnf1 LRS4 PF10422.7 NM_001199662.1_2 - 0.93 8.9 3.3 1.7 8.0 3.3 1.4 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DAG1 PF05454.9 NM_001177643.2_2 - 5.6e-162 537.8 7.3 8.1e-162 537.3 7.3 1.2 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) TMEM154 PF15102.4 NM_001177643.2_2 - 0.008 16.0 0.0 0.008 16.0 0.0 1.8 2 0 0 2 2 2 1 TMEM154 protein family DRY_EERY PF09750.7 NM_004592.3_3 - 5.3e-33 114.0 1.8 5.3e-33 114.0 1.8 4.7 4 1 0 4 4 4 1 Alternative splicing regulator Surp PF01805.18 NM_004592.3_3 - 9.2e-27 92.7 11.2 1.7e-13 50.2 0.6 2.9 3 0 0 3 3 3 2 Surp module FANCM-MHF_bd PF16783.3 NM_004592.3_3 - 3.5 7.6 7.7 0.18 11.8 0.9 2.3 2 0 0 2 2 2 0 FANCM to MHF binding domain 7tm_1 PF00001.19 NM_198179.2_2 - 4.5e-56 189.9 18.7 5.9e-56 189.5 18.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_198179.2_2 - 0.0013 18.0 21.9 0.0019 17.5 21.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Herpes_US9 PF06072.9 NM_198179.2_2 - 0.02 14.6 1.2 0.1 12.3 0.4 2.4 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 T4SS_CagC PF16943.3 NM_198179.2_2 - 0.068 13.2 0.2 0.19 11.8 0.2 1.7 1 0 0 1 1 1 0 Cag pathogenicity island, type IV secretory system 7tm_4 PF13853.4 NM_198179.2_2 - 3.6 7.1 20.2 17 4.9 20.2 1.9 1 1 0 1 1 1 0 Olfactory receptor DNA_mis_repair PF01119.17 NM_001321044.1_2 - 1.2e-22 79.6 0.7 2.3e-22 78.8 0.1 1.8 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.4 NM_001321044.1_2 - 1.8e-10 40.7 1.4 3.4e-10 39.8 0.1 2.1 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HMG_box PF00505.17 NM_001321044.1_2 - 2.2e-08 34.3 0.0 4.5e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HATPase_c PF02518.24 NM_001321044.1_2 - 6.5e-07 29.8 0.1 1.4e-06 28.7 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HMG_box_2 PF09011.8 NM_001321044.1_2 - 6.3e-05 23.4 0.9 0.00012 22.5 0.0 1.9 2 0 0 2 2 2 1 HMG-box domain IHABP4_N PF16174.3 NM_015640.3_3 - 9.2e-38 130.3 7.9 9.2e-38 130.3 7.9 1.7 2 0 0 2 2 2 1 Intracellular hyaluronan-binding protein 4 N-terminal HABP4_PAI-RBP1 PF04774.13 NM_015640.3_3 - 2.3e-29 102.5 10.8 2.3e-29 102.5 10.8 2.1 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family fn3 PF00041.19 NM_001098503.1_2 - 1.5e-25 89.2 7.4 1.1e-05 25.5 0.3 5.4 5 0 0 5 5 5 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_001098503.1_2 - 3.7e-08 33.7 5.7 1.3 9.5 3.2 6.2 5 1 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 NM_001098503.1_2 - 0.0014 18.8 0.1 0.32 11.2 0.0 3.7 5 0 0 5 5 5 1 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.7 NM_001098503.1_2 - 0.12 12.8 0.0 30 5.0 0.0 3.9 4 0 0 4 4 4 0 Uncharacterised conserved protein (DUF2369) Ank_2 PF12796.5 NM_022096.5_3 - 4.7e-49 164.8 4.2 7.7e-11 42.3 0.0 5.8 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_022096.5_3 - 1.4e-38 130.6 7.5 2.1e-12 47.2 0.0 8.7 2 2 5 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_022096.5_3 - 5.2e-37 121.5 5.9 8.7e-07 28.7 0.0 9.6 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.4 NM_022096.5_3 - 1.3e-32 111.2 6.2 5.8e-09 35.9 0.2 8.0 4 2 5 9 9 9 7 Ankyrin repeats (many copies) Ank PF00023.28 NM_022096.5_3 - 1e-31 107.8 11.5 1.6e-06 28.2 0.0 9.7 10 1 1 11 11 11 5 Ankyrin repeat EF-hand_6 PF13405.4 NM_022096.5_3 - 0.023 14.5 0.1 0.068 13.0 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain 7tm_1 PF00001.19 NM_005958.4_2 - 1.4e-47 162.1 20.5 2.1e-47 161.5 20.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_005958.4_2 - 7.1e-09 35.3 17.5 9e-09 34.9 17.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_005958.4_2 - 8.3e-09 35.0 19.4 1.4e-08 34.3 19.4 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 NM_005958.4_2 - 2.3e-06 27.4 16.4 4.8e-05 23.1 16.4 2.0 1 1 0 1 1 1 1 Olfactory receptor TctB PF07331.9 NM_005958.4_2 - 0.07 13.3 15.0 0.44 10.7 7.0 2.7 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Brix PF04427.16 NM_001320307.1_2 - 7.1e-29 101.2 0.0 1e-28 100.7 0.0 1.2 1 0 0 1 1 1 1 Brix domain ECH_1 PF00378.18 NM_004824.3_3 - 6.5e-34 117.2 0.0 8.8e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Chromo PF00385.22 NM_004824.3_3 - 1.1e-17 63.5 3.2 2.1e-17 62.6 3.2 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ECH_2 PF16113.3 NM_004824.3_3 - 1.4e-16 60.9 0.9 9.2e-16 58.1 0.0 2.0 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Mtf2_C PF14061.4 NM_004824.3_3 - 0.014 15.4 0.1 0.029 14.4 0.1 1.5 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Tudor-knot PF11717.6 NM_004824.3_3 - 0.094 12.5 2.1 0.21 11.4 0.4 2.3 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain EMP70 PF02990.14 NM_001014842.2_1 - 4.2e-117 391.8 0.0 5.4e-117 391.4 0.0 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 CorA PF01544.16 NM_001014842.2_1 - 0.032 13.4 0.4 0.056 12.6 0.4 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF3792 PF12670.5 NM_001014842.2_1 - 6 6.9 20.3 0.44 10.6 14.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) Keratin_B2_2 PF13885.4 NM_198698.1_1 - 7.8e-06 25.6 89.8 0.00057 19.6 45.2 3.7 1 1 3 4 4 4 3 Keratin, high sulfur B2 protein His_Phos_1 PF00300.20 NM_001001895.2_1 - 2.1e-22 79.7 0.0 1.2e-20 74.0 0.0 2.4 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) SH3_9 PF14604.4 NM_001001895.2_1 - 6.8e-14 51.3 0.1 1.2e-13 50.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001001895.2_1 - 1.7e-05 24.2 0.0 3.1e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain UBA PF00627.29 NM_001001895.2_1 - 0.0044 16.8 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain SH3_2 PF07653.15 NM_001001895.2_1 - 0.014 15.0 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain Ldl_recept_a PF00057.16 NM_001322226.1_3 - 2.9e-90 296.0 141.7 1.9e-14 53.5 12.7 8.3 8 0 0 8 8 8 7 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 NM_001322226.1_3 - 6.3e-65 215.3 8.4 2.1e-15 56.8 0.1 5.5 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 NM_001322226.1_3 - 1.2e-15 57.3 35.9 1.2e-08 35.0 4.6 6.0 5 1 0 5 5 5 3 Coagulation Factor Xa inhibitory site cEGF PF12662.5 NM_001322226.1_3 - 3e-10 39.7 24.8 3.6e-05 23.5 1.8 5.5 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF_CA PF07645.13 NM_001322226.1_3 - 1.7e-07 31.2 6.0 1.7e-07 31.2 6.0 9.6 6 2 2 8 8 8 3 Calcium-binding EGF domain SGL PF08450.10 NM_001322226.1_3 - 0.0002 20.9 0.5 0.33 10.4 0.2 2.4 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region EGF PF00008.25 NM_001322226.1_3 - 0.0031 17.7 2.6 0.0031 17.7 2.6 8.7 7 1 1 8 8 8 3 EGF-like domain IL1 PF00340.17 NM_173205.1_1 - 2.6e-12 46.3 0.0 3.8e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Interleukin-1 / 18 TIM21 PF08294.9 NM_014177.2_2 - 1.9e-46 157.4 0.1 2.7e-46 156.9 0.1 1.2 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.8 NM_014177.2_2 - 7.6e-05 22.3 0.0 0.00038 20.1 0.0 2.1 2 1 0 2 2 2 1 Cytochrome oxidase complex assembly protein 1 HSP70 PF00012.18 NM_001286504.1_1 - 6.1e-172 572.8 2.7 6.1e-172 572.8 2.7 2.9 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.11 NM_001286504.1_1 - 1e-05 24.4 0.0 1.9e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein SH3_1 PF00018.26 NM_172168.2_2 - 1.2e-12 47.1 0.0 1.4e-07 30.8 0.0 2.3 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 NM_172168.2_2 - 9.8e-12 44.4 0.1 1.3e-07 31.2 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.15 NM_172168.2_2 - 2.4e-06 27.0 0.0 0.0014 18.2 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.22 NM_172168.2_2 - 7.2e-05 22.6 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 PX domain p47_phox_C PF08944.9 NM_172168.2_2 - 0.019 14.2 5.9 0.065 12.5 5.9 1.9 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain SH3_3 PF08239.9 NM_172168.2_2 - 0.078 13.1 0.0 17 5.7 0.0 2.4 2 0 0 2 2 2 0 Bacterial SH3 domain HAUS5 PF14817.4 NM_015302.1_1 - 7.2e-188 626.2 27.0 8.5e-188 626.0 27.0 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 SLX9 PF15341.4 NM_015302.1_1 - 0.0086 16.4 3.0 0.043 14.1 1.7 2.2 2 0 0 2 2 2 1 Ribosome biogenesis protein SLX9 RF-1 PF00472.18 NM_015302.1_1 - 0.13 12.1 0.1 0.13 12.1 0.1 3.3 2 1 1 3 3 3 0 RF-1 domain Keratin_matx PF04579.10 NM_031958.1_2 - 2.4e-48 162.3 34.9 2.4e-48 162.3 34.9 1.4 2 0 0 2 2 2 1 Keratin, high-sulphur matrix protein Condensin2nSMC PF12422.6 NM_017760.6_1 - 1.8e-56 190.4 3.8 2.3e-56 190.0 0.4 3.2 3 0 0 3 3 3 1 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.20 NM_017760.6_1 - 8.5e-08 31.7 0.2 9.3 6.7 0.0 6.1 5 0 0 5 5 5 2 HEAT repeat Adaptin_N PF01602.18 NM_017760.6_1 - 3.2e-05 22.6 1.0 0.0015 17.1 0.0 2.6 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.5 NM_017760.6_1 - 3.6e-05 23.7 1.1 0.018 14.9 0.0 3.9 2 2 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 NM_017760.6_1 - 0.0059 16.8 0.1 0.68 10.2 0.0 3.3 3 1 0 3 3 3 1 HEAT repeats RPAP3_C PF13877.4 NM_017760.6_1 - 0.25 11.8 1.1 5 7.6 0.0 3.5 3 0 0 3 3 3 0 Potential Monad-binding region of RPAP3 DUF577 PF04510.10 NM_017760.6_1 - 0.63 9.8 4.2 0.76 9.5 0.0 3.2 4 0 0 4 4 4 0 Family of unknown function (DUF577) DGCR6 PF07324.9 NM_033257.3_1 - 1.5e-93 311.7 12.8 1.8e-93 311.5 12.8 1.1 1 0 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein DUF2458 PF10454.7 NM_033257.3_1 - 0.029 13.9 2.8 0.056 13.0 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) TRAF_BIRC3_bd PF16673.3 NM_033257.3_1 - 0.36 10.5 7.8 0.74 9.5 4.4 2.5 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain Macoilin PF09726.7 NM_033257.3_1 - 0.56 8.6 6.8 0.68 8.3 6.8 1.1 1 0 0 1 1 1 0 Transmembrane protein FAM178 PF14816.4 NM_001136123.1_3 - 3.7e-148 493.3 1.6 3.7e-148 493.3 1.6 1.9 2 0 0 2 2 2 1 Family of unknown function, FAM178 BCL_N PF04714.11 NM_001286526.1_2 - 1.4e-26 92.1 7.7 2.8e-26 91.2 7.7 1.5 1 0 0 1 1 1 1 BCL7, N-terminal conserver region Syntaphilin PF15290.4 NM_001099750.1_2 - 1.1e-138 462.0 0.8 1.1e-138 462.0 0.8 1.9 2 0 0 2 2 1 1 Golgi-localised syntaxin-1-binding clamp Fez1 PF06818.13 NM_001099750.1_2 - 0.00014 22.2 7.1 0.00026 21.3 7.1 1.3 1 0 0 1 1 1 1 Fez1 FAM76 PF16046.3 NM_001099750.1_2 - 0.0008 18.7 5.5 0.0008 18.7 5.5 2.0 2 1 1 3 3 3 2 FAM76 protein PKcGMP_CC PF16808.3 NM_001099750.1_2 - 0.0084 15.8 5.8 0.0084 15.8 5.8 3.3 4 1 0 4 4 3 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Exonuc_VII_L PF02601.13 NM_001099750.1_2 - 0.029 13.8 1.6 0.045 13.2 1.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FPP PF05911.9 NM_001099750.1_2 - 0.08 11.1 11.8 0.12 10.5 11.8 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil IncA PF04156.12 NM_001099750.1_2 - 0.11 12.1 8.4 0.28 10.8 8.4 1.6 1 0 0 1 1 1 0 IncA protein Atg14 PF10186.7 NM_001099750.1_2 - 0.16 10.9 6.5 0.34 9.8 6.5 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BST2 PF16716.3 NM_001099750.1_2 - 0.26 11.8 7.8 0.61 10.6 7.8 1.6 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 Sec2p PF06428.9 NM_001099750.1_2 - 0.28 11.0 12.7 0.12 12.2 2.5 2.6 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p Sec8_exocyst PF04048.12 NM_001099750.1_2 - 0.29 10.9 7.4 0.82 9.5 0.3 2.3 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain HR1 PF02185.14 NM_001099750.1_2 - 0.46 10.5 9.8 0.7 9.9 1.4 2.5 2 0 0 2 2 2 0 Hr1 repeat DUF342 PF03961.11 NM_001099750.1_2 - 0.51 8.7 4.3 0.72 8.2 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF745 PF05335.11 NM_001099750.1_2 - 1.5 8.4 6.3 2.4 7.7 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Spc42p PF11544.6 NM_001099750.1_2 - 1.6 8.7 7.1 0.43 10.5 1.1 2.4 2 0 0 2 2 2 0 Spindle pole body component Spc42p HMMR_N PF15905.3 NM_001099750.1_2 - 2.3 7.5 16.8 0.013 14.9 8.2 1.5 2 0 0 2 2 1 0 Hyaluronan mediated motility receptor N-terminal DUF16 PF01519.14 NM_001099750.1_2 - 2.4 8.6 8.9 30 5.0 8.9 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 CC2-LZ PF16516.3 NM_001099750.1_2 - 2.7 8.2 11.6 2.6 8.3 3.0 2.3 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator CALCOCO1 PF07888.9 NM_001099750.1_2 - 3.9 5.8 18.7 0.044 12.2 11.1 1.5 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TPR_MLP1_2 PF07926.10 NM_001099750.1_2 - 5.1 7.0 13.6 1.3 8.9 6.6 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 NM_001099750.1_2 - 5.8 5.6 14.5 2.1 7.0 11.1 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein GrpE PF01025.17 NM_001099750.1_2 - 6.1 6.3 9.1 10 5.6 9.1 1.2 1 0 0 1 1 1 0 GrpE Alpha-amylase PF00128.22 NM_000341.3_1 - 4e-85 286.2 3.6 5.7e-85 285.7 3.6 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain SLC3A2_N PF16028.3 NM_000341.3_1 - 0.00012 21.4 0.1 0.00024 20.5 0.1 1.4 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus RabGAP-TBC PF00566.16 NM_001271846.1_1 - 1e-43 149.4 0.4 1.3e-43 149.0 0.4 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Afaf PF15339.4 NM_001271846.1_1 - 0.086 12.5 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 Acrosome formation-associated factor Mito_carr PF00153.25 NM_001278251.2_2 - 3.4e-59 196.7 0.6 1.9e-20 72.4 0.1 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein 2OG-FeII_Oxy_2 PF13532.4 NM_032878.3_1 - 7.4e-15 55.6 0.0 1.3e-13 51.5 0.0 1.9 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily RCC1 PF00415.16 NM_000328.2_1 - 1.6e-71 236.6 17.3 2.3e-12 47.2 0.3 8.1 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 NM_000328.2_1 - 1.7e-36 123.1 29.6 3.2e-09 36.2 0.0 8.2 9 0 0 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.4 NM_000328.2_1 - 8.4e-08 31.9 5.2 0.14 12.0 0.4 5.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_000328.2_1 - 0.073 12.9 3.3 43 4.1 0.0 3.9 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.4 NM_000328.2_1 - 0.08 13.1 3.0 36 4.7 0.0 3.8 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.13 NM_000328.2_1 - 0.091 12.6 0.3 31 4.6 0.0 4.0 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.23 NM_000328.2_1 - 5.6 6.5 7.8 3.4 7.2 0.1 3.7 5 0 0 5 5 5 0 Kelch motif Ras PF00071.20 NM_001252037.1_3 - 4.9e-39 133.4 0.8 1.1e-32 112.7 0.1 2.2 1 1 1 2 2 2 2 Ras family Roc PF08477.11 NM_001252037.1_3 - 7.5e-27 93.8 0.0 1.2e-26 93.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001252037.1_3 - 1.4e-06 27.7 0.0 2.1e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001252037.1_3 - 0.009 16.0 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_001252037.1_3 - 0.16 11.2 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DENN PF02141.19 NM_015689.4_2 - 1.2e-55 188.3 3.2 2e-55 187.5 3.2 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 NM_015689.4_2 - 3.6e-16 59.6 0.3 8.4e-16 58.4 0.3 1.7 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 NM_015689.4_2 - 8.6e-12 44.7 1.9 2.2e-11 43.4 1.9 1.7 1 0 0 1 1 1 1 dDENN domain TAFH PF07531.12 NM_015689.4_2 - 0.13 12.1 0.1 0.37 10.7 0.1 1.7 1 0 0 1 1 1 0 NHR1 homology to TAF SPA PF08616.8 NM_015689.4_2 - 0.14 11.9 0.2 0.25 11.2 0.2 1.3 1 0 0 1 1 1 0 Stabilization of polarity axis Bromodomain PF00439.23 NM_001726.4_1 - 8.3e-42 141.0 6.1 2e-21 75.7 0.5 2.7 2 0 0 2 2 2 2 Bromodomain BET PF17035.3 NM_001726.4_1 - 5.7e-28 96.8 0.1 2.1e-27 94.9 0.1 2.1 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRD4_CDT PF17105.3 NM_001726.4_1 - 1.4e-22 78.9 5.3 4.5e-22 77.3 5.3 2.0 1 0 0 1 1 1 1 C-terminal domain of bromodomain protein 4 DUF2079 PF09852.7 NM_001726.4_1 - 0.11 11.1 0.3 0.18 10.5 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) PAP2 PF01569.19 NM_176895.2_3 - 3.1e-27 94.9 0.7 5.9e-27 94.0 0.7 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 NM_176895.2_3 - 0.00091 19.6 2.3 0.0025 18.2 2.3 1.7 1 0 0 1 1 1 1 PAP2 superfamily C-terminal DUF846 PF05832.10 NM_001316920.1_3 - 5.7e-55 185.0 9.3 5.7e-55 185.0 9.3 2.4 3 0 0 3 3 3 1 Eukaryotic protein of unknown function (DUF846) HXXEE PF13787.4 NM_001316920.1_3 - 1.4 9.5 6.7 3.1 8.5 0.7 2.5 1 1 1 2 2 2 0 Protein of unknown function with HXXEE motif eIF-3c_N PF05470.10 NM_001286478.1_1 - 1.9e-264 878.4 32.9 1.1e-262 872.5 32.9 2.1 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.25 NM_001286478.1_1 - 5.4e-17 62.1 0.4 1.6e-16 60.5 0.1 2.1 2 0 0 2 2 2 1 PCI domain LAM_C PF12544.6 NM_001286478.1_1 - 2.6 8.1 8.4 0.26 11.4 2.8 2.2 1 1 1 2 2 2 0 Lysine-2,3-aminomutase DUF4674 PF15719.3 NM_001286478.1_1 - 3.8 7.3 8.7 9.8 6.0 8.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) DUF496 PF04363.10 NM_001286478.1_1 - 4.6 7.2 10.5 0.91 9.5 0.4 4.2 4 1 1 5 5 5 0 Protein of unknown function (DUF496) Sortilin-Vps10 PF15902.3 NM_003105.5_1 - 1.6e-112 376.5 0.0 2.2e-112 376.0 0.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.16 NM_003105.5_1 - 8.5e-110 358.5 207.6 2.5e-13 49.9 12.4 12.8 11 1 1 12 12 12 11 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.3 NM_003105.5_1 - 7.2e-41 140.2 0.2 7.2e-41 140.2 0.2 4.8 3 1 1 4 4 1 1 Sortilin, neurotensin receptor 3, C-terminal fn3 PF00041.19 NM_003105.5_1 - 7.9e-36 122.2 8.2 5e-08 33.0 0.0 6.4 6 0 0 6 6 6 5 Fibronectin type III domain Ldl_recept_b PF00058.15 NM_003105.5_1 - 6e-24 84.1 7.0 2.9e-06 27.5 0.2 5.7 5 0 0 5 5 5 4 Low-density lipoprotein receptor repeat class B Pur_ac_phosph_N PF16656.3 NM_003105.5_1 - 9e-09 35.7 9.6 0.0046 17.4 0.0 5.1 5 0 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 NM_003105.5_1 - 2.6e-06 27.6 5.4 0.075 13.2 0.9 4.6 4 0 0 4 4 4 1 Interferon-alpha/beta receptor, fibronectin type III BNR_6 PF15899.3 NM_003105.5_1 - 0.00045 19.9 3.4 0.62 10.2 0.6 3.3 2 0 0 2 2 2 2 BNR-Asp box repeat DUF4945 PF16303.3 NM_003105.5_1 - 0.0047 16.7 1.7 0.44 10.4 0.2 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4945) BNR PF02012.18 NM_003105.5_1 - 0.068 13.1 17.2 3.2 8.0 0.2 5.5 5 0 0 5 5 5 0 BNR/Asp-box repeat Tissue_fac PF01108.15 NM_003105.5_1 - 0.66 9.7 8.8 8.8 6.1 2.7 4.4 4 1 0 4 4 4 0 Tissue factor I-set PF07679.14 NM_001144058.1_2 - 6.8e-40 134.9 0.5 2.9e-13 49.6 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001144058.1_2 - 1.1e-35 121.9 10.5 2.4e-14 53.5 0.0 3.7 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 NM_001144058.1_2 - 8.9e-31 105.8 4.1 2.5e-14 53.1 0.0 4.3 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_001144058.1_2 - 3e-30 104.2 2.0 2.8e-12 46.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_001144058.1_2 - 3.1e-13 49.7 7.7 1.2e-07 31.7 0.4 5.2 3 2 1 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_001144058.1_2 - 1.3e-07 31.8 0.1 0.1 12.9 0.0 3.6 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 NM_001144058.1_2 - 1.3e-05 25.0 0.2 0.05 13.5 0.1 3.7 3 1 0 3 3 3 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 NM_001144058.1_2 - 0.0079 16.1 2.3 1.1 9.2 0.0 2.9 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.9 NM_001144058.1_2 - 0.048 13.5 0.3 2.8 7.8 0.1 2.5 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain DMAP1 PF05499.10 NM_019100.4_2 - 3.2e-74 248.2 8.4 6e-74 247.3 8.4 1.5 1 0 0 1 1 1 1 DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like PF16282.3 NM_019100.4_2 - 7.2e-33 112.5 4.1 1.4e-32 111.6 4.1 1.5 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DUF342 PF03961.11 NM_019100.4_2 - 0.36 9.3 2.6 0.65 8.4 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) FAM104 PF15434.4 NM_001166699.1_1 - 3.8e-32 111.0 3.5 4.5e-32 110.7 1.9 1.8 2 0 0 2 2 2 1 Family 104 EF-hand_1 PF00036.30 NM_001305626.1_3 - 6.5e-39 128.5 9.6 8.1e-09 34.3 0.4 4.8 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 NM_001305626.1_3 - 6.3e-34 116.2 2.7 1.8e-17 63.4 0.7 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 NM_001305626.1_3 - 1.1e-30 105.0 8.7 1.3e-14 53.6 0.4 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.4 NM_001305626.1_3 - 3.1e-23 80.1 6.9 1.6e-05 24.1 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 NM_001305626.1_3 - 3.5e-23 79.4 16.9 2.1e-08 33.3 0.1 5.1 5 0 0 5 5 4 4 EF-hand domain EF-hand_9 PF14658.4 NM_001305626.1_3 - 6.5e-13 48.7 0.2 7.4e-08 32.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 NM_001305626.1_3 - 2.4e-07 30.5 0.2 0.0018 18.1 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 NM_001305626.1_3 - 3.2e-05 24.1 0.0 0.14 12.4 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.8 NM_001305626.1_3 - 0.0011 18.9 0.1 0.0028 17.6 0.1 1.7 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.9 NM_001305626.1_3 - 0.0016 19.2 0.0 0.03 15.0 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.11 NM_001305626.1_3 - 0.012 15.5 0.0 0.77 9.7 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) DUF1103 PF06513.9 NM_001305626.1_3 - 0.057 12.9 1.6 0.082 12.4 1.6 1.1 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) RasGEF PF00617.17 NM_005739.3_2 - 4.9e-44 150.4 0.1 8.4e-44 149.6 0.1 1.3 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 NM_005739.3_2 - 5.4e-14 51.7 9.4 5.4e-14 51.7 9.4 1.8 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_6 PF13405.4 NM_005739.3_2 - 6.5e-08 31.8 0.1 0.00012 21.6 0.1 3.1 3 0 0 3 3 2 2 EF-hand domain RasGEF_N PF00618.18 NM_005739.3_2 - 7.8e-07 29.2 0.1 2.8e-06 27.4 0.1 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif EF-hand_7 PF13499.4 NM_005739.3_2 - 2.8e-06 27.6 4.3 0.00045 20.5 1.3 3.6 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_005739.3_2 - 2.9e-06 26.3 8.1 8.5e-05 21.7 0.2 3.6 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.4 NM_005739.3_2 - 0.00022 20.5 6.5 0.0017 17.7 0.1 3.7 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.4 NM_005739.3_2 - 0.024 14.2 4.1 0.12 12.0 0.1 3.1 3 0 0 3 3 3 0 EF-hand domain pair ZapB PF06005.10 NM_005739.3_2 - 0.21 11.9 6.6 5.5 7.4 4.9 2.5 2 0 0 2 2 2 0 Cell division protein ZapB bZIP_1 PF00170.19 NM_005739.3_2 - 0.63 10.1 5.1 1.5 8.8 5.1 1.6 1 0 0 1 1 1 0 bZIP transcription factor DivIC PF04977.13 NM_005739.3_2 - 0.97 9.1 3.3 2.2 8.0 3.3 1.5 1 0 0 1 1 1 0 Septum formation initiator FlaC_arch PF05377.9 NM_005739.3_2 - 3.7 7.9 4.6 80 3.6 0.7 3.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Cadherin PF00028.15 NM_001040429.2_2 - 1.2e-86 285.2 0.0 3e-18 65.9 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_001040429.2_2 - 5.1e-16 58.1 0.0 4.7e-14 51.8 0.0 3.3 3 1 0 3 3 3 1 Cadherin-like Cadherin_3 PF16184.3 NM_001040429.2_2 - 4.7e-06 26.4 0.3 3 7.7 0.0 4.4 4 0 0 4 4 4 3 Cadherin-like Cadherin_C_2 PF16492.3 NM_001040429.2_2 - 0.00029 21.4 0.0 0.00076 20.1 0.0 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal REV PF00424.16 NM_014656.2_1 - 1.7 8.6 8.3 3.2 7.7 8.3 1.4 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) ETRAMP PF09716.8 NM_014656.2_3 - 0.1 12.5 0.2 0.21 11.5 0.2 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) FAM176 PF14851.4 NM_014656.2_3 - 0.14 11.7 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 FAM176 family Pkinase PF00069.23 NM_001142610.1_3 - 6.1e-69 232.2 0.0 9.1e-69 231.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001142610.1_3 - 8.3e-49 166.1 0.0 1.3e-48 165.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.6 NM_001142610.1_3 - 1.5e-24 86.7 3.1 2.5e-24 85.9 3.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Kdo PF06293.12 NM_001142610.1_3 - 2.4e-07 30.2 0.1 4.5e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 NM_001142610.1_3 - 2.2e-05 24.0 0.0 3.9e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.4 NM_001142610.1_3 - 0.0075 15.5 0.0 0.03 13.5 0.0 1.9 1 1 0 1 1 1 1 Kinase-like APH PF01636.21 NM_001142610.1_3 - 0.031 14.1 0.0 0.072 12.9 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-B_box PF00643.22 NM_001320987.1_2 - 1e-08 35.0 8.7 1e-08 35.0 8.7 2.2 2 0 0 2 2 2 1 B-box zinc finger MATH PF00917.24 NM_001320987.1_2 - 1.3e-07 31.6 0.0 3.6e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 MATH domain MRFAP1 PF15155.4 NM_001320987.1_2 - 0.25 11.7 3.8 0.25 11.7 1.5 2.1 2 0 0 2 2 2 0 MORF4 family-associated protein1 FUSC PF04632.10 NM_001320987.1_2 - 0.3 9.5 2.7 0.58 8.5 2.7 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF148 PF02520.15 NM_001320987.1_2 - 1 9.4 4.4 0.46 10.5 1.4 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF148 DUF2203 PF09969.7 NM_001320987.1_2 - 2.6 8.7 5.4 44 4.7 3.0 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Baculo_PEP_C PF04513.10 NM_001320987.1_2 - 8.5 6.3 10.2 2 8.3 2.4 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Allexi_40kDa PF05549.9 NM_001320987.1_2 - 9.8 5.5 9.4 25 4.1 3.5 2.9 2 1 1 3 3 3 0 Allexivirus 40kDa protein Ldl_recept_b PF00058.15 NM_001178131.2_3 - 2.2e-41 140.0 5.0 8.7e-10 38.8 0.0 9.0 10 0 0 10 10 10 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 NM_001178131.2_3 - 3.4e-22 78.3 117.4 2.8e-08 33.8 7.0 9.5 10 0 0 10 10 10 5 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 NM_001178131.2_3 - 1.3e-20 73.1 32.0 4.7e-10 39.4 6.0 8.5 8 0 0 8 8 8 3 Calcium-binding EGF domain EGF PF00008.25 NM_001178131.2_3 - 2.6e-19 69.0 88.8 0.00011 22.3 2.6 8.8 8 0 0 8 8 8 7 EGF-like domain cEGF PF12662.5 NM_001178131.2_3 - 3.7e-13 49.0 63.4 5.7e-05 22.8 1.3 7.9 9 0 0 9 9 9 5 Complement Clr-like EGF-like DUF5050 PF16472.3 NM_001178131.2_3 - 5.6e-11 42.1 0.0 6.9e-05 22.1 0.1 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF5050) EGF_3 PF12947.5 NM_001178131.2_3 - 2e-10 40.6 87.1 1.2e-05 25.2 5.5 8.5 8 1 1 9 9 9 4 EGF domain SGL PF08450.10 NM_001178131.2_3 - 0.00048 19.7 0.2 8.5 5.7 0.0 4.3 3 2 1 4 4 4 2 SMP-30/Gluconolaconase/LRE-like region ThiF PF00899.19 NM_001320210.1_3 - 2.7e-47 161.0 0.1 4.1e-47 160.5 0.1 1.1 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.12 NM_001320210.1_3 - 0.013 15.0 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.16 NM_001320210.1_3 - 0.096 12.8 0.5 1.4 9.0 0.5 2.2 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain WD40 PF00400.30 NM_018093.3_1 - 6.3e-10 39.4 0.9 0.12 13.1 0.0 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_018093.3_1 - 0.0097 16.1 0.0 0.29 11.3 0.0 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain MFS_1 PF07690.14 NM_001164279.1_1 - 7.4e-43 146.7 45.0 7e-40 136.9 27.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_001164279.1_1 - 0.01 14.6 28.2 0.15 10.8 9.1 4.0 3 1 0 4 4 4 0 Sugar (and other) transporter PTR2 PF00854.19 NM_001164279.1_1 - 9.9 4.7 10.7 0.066 11.9 0.6 2.2 3 0 0 3 3 3 0 POT family TFIIA PF03153.11 NM_201595.2_1 - 1.6e-89 301.7 68.7 6.2e-52 177.9 24.8 2.1 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit SSDP PF04503.11 NM_032627.4_2 - 2.8e-83 280.4 67.7 4.1e-83 279.8 67.7 1.3 1 0 0 1 1 1 1 Single-stranded DNA binding protein, SSDP EGF_CA PF07645.13 NM_016938.4_2 - 3.2e-48 161.5 81.2 1.9e-11 43.8 5.4 8.2 8 0 0 8 8 8 6 Calcium-binding EGF domain cEGF PF12662.5 NM_016938.4_2 - 5.8e-36 121.9 57.0 5.7e-10 38.8 0.4 7.7 8 0 0 8 8 8 6 Complement Clr-like EGF-like FXa_inhibition PF14670.4 NM_016938.4_2 - 2.6e-11 43.5 99.8 2.1e-06 27.8 7.6 9.2 9 1 0 9 9 9 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 NM_016938.4_2 - 8.5e-07 28.9 64.0 5.6e-05 23.1 5.8 7.3 7 1 0 7 7 7 4 EGF domain EGF PF00008.25 NM_016938.4_2 - 8.5e-05 22.6 85.6 0.0018 18.4 7.9 8.1 8 0 0 8 8 8 4 EGF-like domain hEGF PF12661.5 NM_016938.4_2 - 0.0057 17.2 14.4 0.0076 16.8 4.0 10.0 10 0 0 10 10 10 4 Human growth factor-like EGF Adipogenin PF15202.4 NM_016938.4_2 - 0.068 13.1 0.5 0.16 11.9 0.5 1.5 1 0 0 1 1 1 0 Adipogenin DUF3767 PF12597.6 NM_001312874.1_2 - 0.08 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) DUF3767 PF12597.6 NM_001312874.1_3 - 0.013 15.2 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) Ras PF00071.20 NM_001172666.1_3 - 1.1e-28 99.8 0.1 2.5e-23 82.3 0.0 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.11 NM_001172666.1_3 - 3.2e-17 62.7 0.0 4.8e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SOCS_box PF07525.14 NM_001172666.1_3 - 4.2e-07 30.1 0.4 1e-06 28.9 0.4 1.7 1 0 0 1 1 1 1 SOCS box Arf PF00025.19 NM_001172666.1_3 - 0.00031 20.1 0.0 0.00048 19.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family CBF PF03914.15 NM_022451.10_1 - 2e-30 105.9 0.2 6e-30 104.3 0.2 1.9 1 0 0 1 1 1 1 CBF/Mak21 family NOC3p PF07540.9 NM_022451.10_1 - 3.1e-30 104.3 1.3 2.4e-29 101.5 1.3 2.7 1 0 0 1 1 1 1 Nucleolar complex-associated protein DUF2732 PF10809.6 NM_022451.10_1 - 0.0063 16.2 0.1 0.024 14.3 0.1 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2732) Scm3 PF10384.7 NM_022451.10_1 - 2.2 7.9 6.1 48 3.7 3.2 3.0 2 0 0 2 2 2 0 Centromere protein Scm3 Mtp PF03821.14 NM_014713.4_2 - 3.8e-21 75.7 15.9 6.7e-15 55.2 5.2 2.2 1 1 1 2 2 2 2 Golgi 4-transmembrane spanning transporter DUF4728 PF15860.3 NM_014713.4_2 - 0.88 10.1 16.9 0.037 14.5 3.9 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4728) DUF4499 PF14934.4 NM_025125.3_1 - 2e-33 114.5 5.6 4.4e-33 113.4 5.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) Na_H_Exchanger PF00999.19 NM_183061.2_2 - 1.5e-27 96.2 40.7 3e-27 95.3 40.7 1.4 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family cNMP_binding PF00027.27 NM_183061.2_2 - 1.5e-11 44.0 0.0 3.8e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.29 NM_183061.2_2 - 6.9e-10 38.4 10.6 6.9e-10 38.4 10.6 3.7 2 1 0 2 2 2 1 Ion transport protein Cauli_DNA-bind PF03310.11 NM_183061.2_2 - 0.22 11.5 0.9 22 5.0 0.1 2.4 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein TACC PF05010.12 NM_001146216.2_2 - 7.1e-80 267.4 34.4 9.8e-80 267.0 34.4 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) HLH PF00010.24 NM_001322154.1_2 - 2.8e-10 39.8 1.5 1e-09 38.1 1.3 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Methyltransf_5 PF01795.17 NM_001297775.1_1 - 1.8e-41 142.5 0.5 4.2e-41 141.3 0.5 1.5 1 1 0 1 1 1 1 MraW methylase family Methyltransf_5 PF01795.17 NM_001297775.1_3 - 6e-37 127.7 0.0 8.1e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 MraW methylase family Methyltr_RsmB-F PF01189.15 NM_001297775.1_3 - 0.00029 20.4 0.0 0.00043 19.8 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F BTB PF00651.29 NM_001318718.1_3 - 2.4e-25 88.8 2.2 4.3e-25 88.0 2.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.4 NM_001318718.1_3 - 1e-17 63.6 1.0 1.5e-05 24.9 0.0 4.9 3 1 1 4 4 4 3 Kelch motif BACK PF07707.13 NM_001318718.1_3 - 2e-11 43.8 0.9 1.4e-09 37.8 0.2 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.13 NM_001318718.1_3 - 2.8e-08 33.3 0.4 0.0015 18.3 0.2 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.23 NM_001318718.1_3 - 3.8e-06 26.2 1.4 0.024 14.1 0.0 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.4 NM_001318718.1_3 - 0.0024 17.6 1.0 0.39 10.6 0.0 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Ferritin PF00210.22 NM_177478.1_1 - 5.9e-36 123.4 3.3 7.5e-36 123.0 3.3 1.1 1 0 0 1 1 1 1 Ferritin-like domain p450 PF00067.20 NM_001319155.1_1 - 1.7e-120 402.8 0.0 3.5e-91 306.1 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 HCO3_cotransp PF00955.19 NM_001321104.1_1 - 1.2e-244 812.7 7.4 1.6e-244 812.3 7.4 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 NM_001321104.1_1 - 1.6e-104 349.3 0.0 4.6e-104 347.9 0.0 1.8 1 1 0 1 1 1 1 Band 3 cytoplasmic domain I-set PF07679.14 NM_001291937.1_3 - 1.8e-21 75.8 0.1 3.2e-11 43.0 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001291937.1_3 - 1.2e-15 57.7 1.9 7.7e-10 39.1 0.2 2.7 2 0 0 2 2 2 2 Immunoglobulin domain TPKR_C2 PF16920.3 NM_001291937.1_3 - 8.8e-15 54.4 1.9 2.1e-14 53.2 1.9 1.7 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain Ig_2 PF13895.4 NM_001291937.1_3 - 5e-12 45.9 1.8 3.2e-08 33.7 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001291937.1_3 - 2e-10 40.5 0.4 5.6e-08 32.7 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.4 NM_001291937.1_3 - 3.3e-09 36.2 3.3 6e-09 35.4 3.3 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRRNT PF01462.16 NM_001291937.1_3 - 1.9e-07 30.5 3.6 7.1e-07 28.6 3.6 2.1 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain V-set PF07686.15 NM_001291937.1_3 - 0.0051 16.8 1.2 1.1 9.4 0.0 2.9 2 1 1 3 3 3 2 Immunoglobulin V-set domain BRO1 PF03097.16 NM_033103.4_1 - 2.7e-88 296.2 0.2 4.5e-88 295.5 0.2 1.3 1 0 0 1 1 1 1 BRO1-like domain HR1 PF02185.14 NM_033103.4_1 - 3.7e-13 49.2 2.9 8.2e-13 48.1 2.9 1.6 1 0 0 1 1 1 1 Hr1 repeat PDZ PF00595.22 NM_033103.4_1 - 0.031 14.5 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) TMEM108 PF15759.3 NM_000676.2_2 - 7.6 5.1 5.7 11 4.6 5.7 1.1 1 0 0 1 1 1 0 TMEM108 family 7tm_1 PF00001.19 NM_000676.2_3 - 1.1e-53 182.1 17.0 1.8e-53 181.3 17.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_000676.2_3 - 1.1e-13 51.1 14.2 1.9e-12 47.0 14.2 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_000676.2_3 - 9.2e-12 45.1 13.2 4.7e-11 42.8 13.2 2.0 1 1 0 1 1 1 1 Olfactory receptor GPR_Gpa2_C PF11970.6 NM_000676.2_3 - 0.063 13.2 0.1 0.18 11.8 0.1 1.8 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term 7TM_GPCR_Srx PF10328.7 NM_000676.2_3 - 0.16 11.1 13.0 0.12 11.5 11.6 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx FBA PF04300.11 NM_001014765.1_1 - 1.3e-71 240.0 0.1 1.7e-71 239.6 0.1 1.1 1 0 0 1 1 1 1 F-box associated region F-box-like PF12937.5 NM_001014765.1_1 - 4e-08 32.9 4.8 1e-07 31.6 4.8 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_001014765.1_1 - 1.6e-07 30.9 4.1 4e-07 29.6 4.1 1.6 1 0 0 1 1 1 1 F-box domain CENP-R PF06729.10 NM_001206739.1_3 - 1e-63 213.3 11.4 1.3e-63 212.9 11.4 1.1 1 0 0 1 1 1 1 Kinetochore component, CENP-R HalX PF08663.8 NM_001206739.1_3 - 0.17 12.0 0.2 0.38 10.9 0.2 1.5 1 0 0 1 1 1 0 HalX domain EGF PF00008.25 NM_001080437.1_1 - 8.2e-90 294.4 251.8 6.1e-09 35.9 4.1 16.6 16 0 0 16 16 16 16 EGF-like domain hEGF PF12661.5 NM_001080437.1_1 - 2.1e-54 180.3 222.7 7.4e-06 26.3 7.4 17.7 16 1 0 16 16 16 15 Human growth factor-like EGF fn3 PF00041.19 NM_001080437.1_1 - 1.7e-34 117.9 3.2 6.4e-11 42.3 0.2 3.4 3 0 0 3 3 3 3 Fibronectin type III domain EGF_2 PF07974.11 NM_001080437.1_1 - 1.2e-26 92.6 281.2 0.004 17.4 8.0 16.7 16 0 0 16 16 16 15 EGF-like domain NIDO PF06119.12 NM_001080437.1_1 - 4.5e-26 91.5 0.3 8.1e-26 90.7 0.3 1.4 1 0 0 1 1 1 1 Nidogen-like EGF_CA PF07645.13 NM_001080437.1_1 - 2.5e-10 40.3 230.9 0.00018 21.5 6.7 16.5 8 5 8 16 16 16 9 Calcium-binding EGF domain cEGF PF12662.5 NM_001080437.1_1 - 0.001 18.8 0.7 0.001 18.8 0.7 17.4 16 3 0 16 16 16 8 Complement Clr-like EGF-like DUF2369 PF10179.7 NM_001080437.1_1 - 0.059 13.7 0.0 8.6 6.8 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) zf-H2C2_2 PF13465.4 NM_001323652.1_1 - 1.3e-27 94.8 57.8 1.2e-07 31.7 5.1 7.9 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001323652.1_1 - 3.3e-23 80.7 66.2 0.00019 21.5 5.0 8.2 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001323652.1_1 - 5.9e-13 48.3 62.2 0.055 14.2 4.4 8.1 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001323652.1_1 - 1.9e-07 31.1 47.4 0.02 15.1 1.7 7.8 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 NM_001323652.1_1 - 2e-07 31.0 25.9 2.9e-07 30.5 1.4 3.9 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 NM_001323652.1_1 - 2.1e-05 24.6 52.7 0.042 14.1 2.4 7.3 7 0 0 7 7 7 5 Zinc-finger of C2H2 type Homeobox PF00046.27 NM_001323652.1_1 - 3.8e-05 23.3 0.0 9.7e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 Homeobox domain zf-C2H2_6 PF13912.4 NM_001323652.1_1 - 0.0041 16.9 58.8 0.94 9.4 0.8 7.7 7 0 0 7 7 7 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001323652.1_1 - 1.2 9.1 21.4 0.16 12.0 2.9 4.5 4 0 0 4 4 4 0 Zinc ribbon domain zf-C2H2_9 PF16293.3 NM_001323652.1_1 - 4.7 7.0 16.7 7.4 6.4 0.1 4.9 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.5 NM_001323652.1_1 - 5.9 7.2 42.8 0.064 13.5 1.1 6.2 2 2 3 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.3 NM_001323652.1_1 - 7.8 6.2 27.6 0.18 11.5 0.5 5.5 5 0 0 5 5 5 0 zinc-finger C2H2-type Ion_trans PF00520.29 NM_001040142.1_3 - 1.4e-256 846.3 106.9 1.7e-81 272.9 16.9 4.3 4 0 0 4 4 4 4 Ion transport protein Na_trans_cytopl PF11933.6 NM_001040142.1_3 - 4.3e-79 265.2 13.4 8.3e-79 264.2 13.4 1.4 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.11 NM_001040142.1_3 - 1.6e-60 204.5 3.7 1.6e-60 204.5 3.7 3.0 3 0 0 3 3 3 1 Sodium ion transport-associated GPHH PF16905.3 NM_001040142.1_3 - 1.3e-05 24.8 0.0 2.7e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.10 NM_001040142.1_3 - 1.4e-05 23.8 79.5 0.00018 20.2 0.1 9.3 6 4 4 10 10 10 6 Polycystin cation channel ATP-synt_B PF00430.16 NM_001040142.1_3 - 0.00079 19.4 4.7 0.00079 19.4 4.7 2.3 2 0 0 2 2 2 1 ATP synthase B/B' CF(0) IQ PF00612.25 NM_001040142.1_3 - 0.0051 16.4 1.0 0.012 15.2 1.0 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif FXa_inhibition PF14670.4 NM_020974.2_1 - 1.1e-61 204.6 177.8 2.7e-11 43.4 9.4 11.7 12 1 0 12 12 12 9 Coagulation Factor Xa inhibitory site cEGF PF12662.5 NM_020974.2_1 - 5.9e-44 147.5 77.8 1.5e-08 34.3 5.2 10.9 10 0 0 10 10 10 9 Complement Clr-like EGF-like EGF_CA PF07645.13 NM_020974.2_1 - 1.3e-30 105.2 156.6 1.2e-09 38.1 8.2 10.7 10 0 0 10 10 10 6 Calcium-binding EGF domain Ephrin_rec_like PF07699.11 NM_020974.2_1 - 3.8e-29 100.1 20.1 3.5e-15 55.4 7.3 3.8 3 0 0 3 3 3 2 Putative ephrin-receptor like EGF_3 PF12947.5 NM_020974.2_1 - 6.6e-19 67.7 140.8 1e-09 38.3 9.5 10.3 9 0 0 9 9 9 8 EGF domain CUB PF00431.18 NM_020974.2_1 - 1e-18 67.6 0.0 2e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 CUB domain EGF PF00008.25 NM_020974.2_1 - 1.8e-11 44.0 140.5 0.0002 21.5 6.7 11.1 11 0 0 11 11 11 8 EGF-like domain hEGF PF12661.5 NM_020974.2_1 - 0.0012 19.4 2.4 0.0012 19.4 2.4 11.6 9 1 0 9 9 9 3 Human growth factor-like EGF zf-C2H2_11 PF16622.3 NM_001304764.1_1 - 1.4e-17 63.0 9.9 1.5e-14 53.3 0.4 8.5 11 0 0 11 11 11 4 zinc-finger C2H2-type zf-C2H2_4 PF13894.4 NM_001304764.1_1 - 1.5e-16 59.5 98.9 0.021 15.5 2.2 14.5 14 0 0 14 14 14 12 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001304764.1_1 - 3.1e-13 49.3 100.4 0.011 16.1 1.9 14.4 14 0 0 14 14 14 11 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001304764.1_1 - 0.00015 21.9 67.6 0.037 14.4 0.5 12.6 13 0 0 13 13 13 5 Zinc-finger double domain zf-met PF12874.5 NM_001304764.1_1 - 0.001 19.2 48.9 0.013 15.7 1.3 9.9 11 0 0 11 11 11 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001304764.1_1 - 0.23 11.7 29.4 0.24 11.6 0.1 8.7 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding Cation_efflux PF01545.19 NM_001004434.2_3 - 4.6e-47 160.2 13.8 7.1e-47 159.6 13.8 1.3 1 0 0 1 1 1 1 Cation efflux family PCI PF01399.25 NM_001270482.1_2 - 1.1e-20 73.9 0.4 2.8e-20 72.6 0.4 1.7 1 0 0 1 1 1 1 PCI domain TPR_12 PF13424.4 NM_001270482.1_2 - 0.022 14.9 10.4 0.071 13.3 2.9 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat DDRGK PF09756.7 NM_001270482.1_2 - 0.025 14.0 0.1 0.05 13.0 0.1 1.4 1 0 0 1 1 1 0 DDRGK domain TPR_21 PF09976.7 NM_001270482.1_2 - 0.12 12.0 0.9 0.26 10.9 0.9 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain BRICHOS PF04089.12 NM_001011705.1_1 - 1.2e-18 66.8 0.0 2.2e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain 7tm_1 PF00001.19 NM_001011705.1_1 - 0.37 9.9 3.9 0.58 9.2 3.9 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF106 PF01956.14 NM_001011705.1_1 - 0.43 10.2 5.9 0.68 9.5 5.9 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF106 Eapp_C PF10238.7 NM_001011705.1_1 - 0.98 9.4 7.6 0.29 11.1 4.5 1.7 2 0 0 2 2 2 0 E2F-associated phosphoprotein GAPT PF11770.6 NM_001011705.1_1 - 1.7 8.4 10.0 2 8.2 0.1 2.4 2 0 0 2 2 2 0 GRB2-binding adapter (GAPT) PEX11 PF05648.12 NM_001011705.1_1 - 1.9 7.8 6.8 2.7 7.3 6.8 1.2 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) ABC_export PF16962.3 NM_001011705.1_1 - 3.6 5.8 5.7 5.9 5.1 5.7 1.3 1 0 0 1 1 1 0 Putative ABC exporter BCS1_N PF08740.9 NM_004328.4_2 - 6.1e-46 156.6 1.8 1e-45 155.9 1.8 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.27 NM_004328.4_2 - 5.8e-18 65.5 0.0 1.2e-17 64.5 0.0 1.5 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 NM_004328.4_2 - 0.00067 19.9 0.1 0.0016 18.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.20 NM_004328.4_2 - 0.00095 19.4 0.0 0.0032 17.7 0.0 1.9 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.4 NM_004328.4_2 - 0.0055 16.2 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.11 NM_004328.4_2 - 0.012 14.7 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.25 NM_004328.4_2 - 0.02 15.3 0.0 0.036 14.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.12 NM_004328.4_2 - 0.031 14.1 0.0 0.1 12.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Polyoma_lg_T_C PF06431.9 NM_004328.4_2 - 0.055 12.2 0.0 0.074 11.8 0.0 1.1 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus AAA_29 PF13555.4 NM_004328.4_2 - 0.073 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.4 NM_004328.4_2 - 0.081 12.9 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.4 NM_004328.4_2 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.13 NM_004328.4_2 - 0.14 10.9 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_18 PF13238.4 NM_004328.4_2 - 0.14 12.5 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 NM_004328.4_2 - 0.18 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase PF06745.11 NM_004328.4_2 - 0.21 10.8 0.0 0.34 10.1 0.0 1.2 1 0 0 1 1 1 0 KaiC Asp PF00026.21 NM_138973.3_3 - 9.3e-32 110.6 0.0 1.7e-19 70.3 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_C PF14541.4 NM_138973.3_3 - 2.9e-10 40.0 0.0 4.8e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.4 NM_138973.3_3 - 0.0075 16.4 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal EF-hand_6 PF13405.4 NM_016350.4_3 - 9.3e-06 25.1 2.7 0.0054 16.4 0.1 4.3 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.30 NM_016350.4_3 - 0.00015 20.9 1.2 0.11 12.0 0.0 4.2 5 0 0 5 5 5 1 EF hand TSC22 PF01166.16 NM_016350.4_3 - 0.00077 19.6 7.9 0.00077 19.6 7.9 11.8 12 1 0 12 12 12 2 TSC-22/dip/bun family EF-hand_7 PF13499.4 NM_016350.4_3 - 0.0013 19.0 15.9 0.051 13.9 0.1 5.1 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_8 PF13833.4 NM_016350.4_3 - 0.045 13.4 0.7 8 6.2 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain pair Peptidase_S15 PF02129.16 NM_016350.4_3 - 1.3 8.4 5.0 5.5 6.4 0.8 3.5 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF2465 PF10239.7 NM_173611.3_3 - 2e-132 441.2 1.5 2.4e-132 441.0 1.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) VIT1 PF01988.17 NM_173611.3_3 - 0.16 11.6 1.0 0.32 10.7 0.6 1.6 1 1 1 2 2 2 0 VIT family Ank_2 PF12796.5 NM_144590.2_3 - 2.8e-19 69.3 0.1 7.5e-10 39.1 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 NM_144590.2_3 - 1.5e-18 66.2 0.0 8.1e-07 29.1 0.0 3.8 3 1 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.4 NM_144590.2_3 - 3.1e-16 59.4 0.4 4.9e-06 26.9 0.1 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_144590.2_3 - 1.7e-14 53.6 1.1 2e-08 34.3 0.1 3.0 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_144590.2_3 - 1.9e-11 43.0 2.3 0.00011 22.2 0.1 5.0 5 0 0 5 5 5 2 Ankyrin repeat DUF4632 PF15451.4 NM_005693.3_1 - 0.0044 16.9 1.9 0.052 13.5 0.1 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4632) Hormone_recep PF00104.28 NM_005693.3_2 - 9.7e-30 103.6 1.8 1.6e-29 102.9 1.8 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_005693.3_2 - 5.3e-27 94.0 13.9 9.8e-27 93.1 13.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) TRF PF08558.8 NM_005652.4_3 - 2.5e-35 122.1 3.6 3.5e-35 121.6 3.6 1.1 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) TERF2_RBM PF16772.3 NM_005652.4_3 - 3.5e-19 67.8 0.1 6.3e-19 67.0 0.1 1.4 1 0 0 1 1 1 1 Telomeric repeat-binding factor 2 Rap1-binding motif Myb_DNA-binding PF00249.29 NM_005652.4_3 - 4.6e-13 48.9 0.8 1.1e-12 47.8 0.8 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 NM_005652.4_3 - 3.6e-05 23.8 0.1 9.6e-05 22.4 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain PCI PF01399.25 NM_005652.4_3 - 0.036 14.5 0.3 0.067 13.6 0.3 1.4 1 0 0 1 1 1 0 PCI domain Sec7 PF01369.18 NM_004762.3_3 - 8.8e-69 230.8 0.2 1.2e-68 230.3 0.2 1.1 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 NM_004762.3_3 - 2.5e-29 101.7 0.1 5.4e-29 100.7 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_004762.3_3 - 9.8e-05 22.6 0.0 0.0002 21.6 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain CEP170_C PF15308.4 NM_004762.3_3 - 0.0032 16.0 0.9 0.0045 15.5 0.9 1.1 1 0 0 1 1 1 1 CEP170 C-terminus PH_8 PF15409.4 NM_004762.3_3 - 0.019 15.1 0.0 0.053 13.7 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain PH_3 PF14593.4 NM_004762.3_3 - 0.042 13.8 0.1 0.12 12.4 0.1 1.7 1 1 0 1 1 1 0 PH domain DUF342 PF03961.11 NM_004762.3_3 - 0.056 11.9 1.6 0.078 11.4 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF812 PF05667.9 NM_004762.3_3 - 0.095 11.5 2.6 0.14 10.9 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) APG6 PF04111.10 NM_004762.3_3 - 0.14 11.4 4.8 0.18 11.0 3.4 1.8 2 0 0 2 2 2 0 Autophagy protein Apg6 GPS2_interact PF15784.3 NM_004762.3_3 - 0.19 12.3 2.7 0.39 11.3 2.7 1.4 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain BBS2_C PF14782.4 NM_004762.3_3 - 0.29 9.7 1.8 2.3 6.8 1.2 2.0 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal POM121 PF15229.4 NM_033482.3_3 - 4.6e-39 134.4 9.1 2.7e-33 115.5 5.3 5.0 4 1 1 5 5 5 3 POM121 family TPR_19 PF14559.4 NM_001321742.1_1 - 8.7e-11 42.1 5.0 0.00012 22.4 0.8 2.9 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001321742.1_1 - 1.4e-10 40.4 8.6 0.00089 19.1 0.2 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001321742.1_1 - 3.9e-10 39.6 9.4 1.6e-06 28.1 0.4 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.26 NM_001321742.1_1 - 7.7e-08 31.7 10.5 0.019 14.6 0.1 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001321742.1_1 - 6.1e-07 29.0 5.3 0.017 15.2 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001321742.1_1 - 7.5e-06 26.0 5.4 0.0052 16.9 0.3 3.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001321742.1_1 - 7.7e-06 25.5 4.1 1.9 8.6 0.2 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001321742.1_1 - 0.00011 22.6 0.8 0.15 12.7 0.0 3.0 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001321742.1_1 - 0.00012 22.1 1.9 0.0017 18.5 0.2 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001321742.1_1 - 0.00012 22.3 2.9 0.22 12.1 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001321742.1_1 - 0.00039 20.9 0.1 1.1 10.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001321742.1_1 - 0.0006 19.8 0.8 0.022 14.8 0.3 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Coatomer_E PF04733.12 NM_001321742.1_1 - 0.0014 18.0 3.7 0.0021 17.4 2.8 1.6 1 1 1 2 2 2 1 Coatomer epsilon subunit TPR_11 PF13414.4 NM_001321742.1_1 - 0.011 15.3 0.2 0.094 12.3 0.0 2.4 2 0 0 2 2 2 0 TPR repeat zf-UBP PF02148.17 NM_001321742.1_1 - 0.11 12.7 0.6 0.48 10.7 0.6 2.2 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein TPR_10 PF13374.4 NM_001321742.1_1 - 0.26 11.1 6.1 5.4 6.9 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat FGF PF00167.16 NM_001321939.1_1 - 7.9e-30 103.4 0.0 1.2e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor ERM PF00769.17 NM_181831.2_3 - 7.2e-64 215.8 38.2 7.2e-64 215.8 38.2 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.8 NM_181831.2_3 - 1.3e-24 86.2 0.0 4.3e-24 84.6 0.0 1.9 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FERM_M PF00373.16 NM_181831.2_3 - 8.6e-23 80.9 0.2 8.6e-23 80.9 0.2 3.1 3 1 0 3 3 3 1 FERM central domain Thymopoietin PF08198.9 NM_001307975.1_2 - 6.8e-29 99.1 0.5 1.6e-28 97.9 0.5 1.7 1 0 0 1 1 1 1 Thymopoietin protein LEM PF03020.13 NM_001307975.1_2 - 6e-18 64.0 2.4 6.1e-18 63.9 1.1 1.7 2 0 0 2 2 2 1 LEM domain PAN_4 PF14295.4 NM_001307975.1_2 - 3.5 7.5 5.6 0.22 11.3 0.2 1.8 2 0 0 2 2 2 0 PAN domain Zip PF02535.20 NM_001282734.1_2 - 4.1e-64 216.8 18.0 6.2e-64 216.2 18.0 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter Voltage_CLC PF00654.18 NM_000083.2_1 - 3.9e-84 282.8 30.4 3.9e-84 282.8 30.4 2.0 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.26 NM_000083.2_1 - 0.17 12.2 0.1 0.56 10.6 0.1 1.9 2 0 0 2 2 2 0 CBS domain DUF4587 PF15248.4 NM_001286462.1_3 - 2e-16 60.4 17.7 4.4e-15 56.1 17.7 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4587) Spectrin PF00435.19 NM_012090.5_2 - 5.3e-219 711.3 437.0 1.2e-17 64.2 4.8 42.8 38 5 3 42 42 42 35 Spectrin repeat CH PF00307.29 NM_012090.5_2 - 3.2e-46 155.9 1.3 8.8e-22 77.2 0.5 4.7 3 0 0 3 3 2 2 Calponin homology (CH) domain GAS2 PF02187.15 NM_012090.5_2 - 3.8e-33 113.3 0.4 1.4e-32 111.5 0.4 2.1 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_1 PF00036.30 NM_012090.5_2 - 1.1e-11 43.2 2.2 0.0001 21.5 0.7 3.1 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 NM_012090.5_2 - 5.9e-11 42.5 0.9 7.2e-10 39.1 0.9 3.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_012090.5_2 - 1.2e-10 40.3 1.6 0.00052 19.6 0.4 3.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 NM_012090.5_2 - 6.4e-08 32.1 1.6 2e-07 30.5 0.2 2.8 3 0 0 3 3 2 1 EF-hand domain pair EF-hand_5 PF13202.4 NM_012090.5_2 - 7.7e-08 31.4 4.1 3e-05 23.2 1.4 2.9 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.6 NM_012090.5_2 - 9.5e-06 25.2 0.1 0.0054 16.4 0.0 3.3 2 0 0 2 2 2 1 CAMSAP CH domain Laminin_II PF06009.10 NM_012090.5_2 - 0.00047 20.1 12.3 0.00055 19.8 5.5 24.3 17 5 7 25 25 24 3 Laminin Domain II CcdA PF07362.10 NM_012090.5_2 - 0.12 12.7 5.1 1.2 9.5 1.6 4.9 2 0 0 2 2 2 0 Post-segregation antitoxin CcdA DUF19 PF01579.16 NM_012090.5_2 - 0.35 10.5 13.9 0.0087 15.7 2.1 4.5 2 0 0 2 2 1 0 Domain of unknown function (DUF19) Peptidase_S49 PF01343.16 NM_012090.5_2 - 0.75 9.6 5.0 3.3 7.5 0.3 4.1 3 0 0 3 3 3 0 Peptidase family S49 DASH_Dam1 PF08653.8 NM_012090.5_2 - 2.2 8.0 19.6 5.2 6.8 0.1 8.8 7 0 0 7 7 7 0 DASH complex subunit Dam1 DELLA PF12041.6 NM_012090.5_2 - 8.5 6.2 20.9 2.4 8.0 0.1 7.7 7 0 0 7 7 7 0 Transcriptional regulator DELLA protein N terminal A2M_comp PF07678.12 NM_002864.2_3 - 8.5e-94 313.5 1.3 1.3e-93 312.9 1.3 1.3 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_N_2 PF07703.12 NM_002864.2_3 - 2.1e-32 112.2 0.0 3.8e-27 95.2 0.0 3.4 2 0 0 2 2 2 2 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 NM_002864.2_3 - 8.8e-31 105.5 1.0 2.8e-30 103.9 0.1 2.5 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_recep PF07677.12 NM_002864.2_3 - 1.1e-25 90.1 2.2 3.2e-25 88.6 2.2 1.9 1 0 0 1 1 1 1 A-macroglobulin receptor A2M_N PF01835.17 NM_002864.2_3 - 6.2e-20 71.3 0.2 7.6e-19 67.8 0.0 2.9 2 0 0 2 2 2 1 MG2 domain Thiol-ester_cl PF10569.7 NM_002864.2_3 - 2e-16 59.3 4.2 4.5e-16 58.1 4.2 1.7 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region SVA PF05326.9 NM_002864.2_3 - 2.6e-06 27.3 0.1 1.2e-05 25.2 0.0 2.2 2 0 0 2 2 2 1 Seminal vesicle autoantigen (SVA) DUF3974 PF13120.4 NM_002864.2_3 - 0.0083 15.9 0.0 2.7 7.8 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3974) DNA_pol_B_palm PF14792.4 NM_002864.2_3 - 0.063 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase beta palm SQHop_cyclase_N PF13249.4 NM_002864.2_3 - 0.12 11.4 0.0 8.6 5.2 0.0 2.9 3 0 0 3 3 3 0 Squalene-hopene cyclase N-terminal domain Ig_2 PF13895.4 NM_205833.3_2 - 3.7e-15 55.9 0.1 5.1e-07 29.8 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_205833.3_2 - 8.7e-06 26.1 0.1 0.085 13.3 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_205833.3_2 - 9.5e-05 22.4 0.4 0.2 11.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_205833.3_2 - 0.0001 22.3 0.0 0.057 13.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin V-set domain HSP70 PF00012.18 NM_006644.3_2 - 9.1e-188 625.1 1.6 9.1e-188 625.1 1.6 2.9 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.11 NM_006644.3_2 - 1e-05 24.4 0.0 2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.4 NM_006644.3_2 - 0.045 14.1 0.2 2.4 8.5 0.0 2.9 3 0 0 3 3 3 0 Cell division protein FtsA tRNA-synt_2b PF00587.23 NM_001271895.1_1 - 1.5e-33 116.1 0.0 2.5e-33 115.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.18 NM_001271895.1_1 - 3.8e-19 68.5 0.1 6.8e-19 67.7 0.1 1.4 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.19 NM_001271895.1_1 - 1e-10 41.3 0.0 2e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.12 NM_001271895.1_1 - 4e-08 33.1 0.1 1.1e-07 31.7 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Kv2channel PF03521.12 NM_004975.3_3 - 8.2e-54 182.8 14.8 4.2e-46 157.5 9.4 2.2 2 0 0 2 2 2 2 Kv2 voltage-gated K+ channel Ion_trans PF00520.29 NM_004975.3_3 - 6.8e-48 162.9 7.4 1.1e-47 162.2 7.4 1.3 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_004975.3_3 - 1.8e-31 108.2 0.0 3.2e-31 107.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_004975.3_3 - 2.9e-11 43.0 2.8 2.9e-11 43.0 2.8 1.9 2 0 0 2 2 2 1 Ion channel RNB PF00773.17 NM_133375.4_3 - 5e-88 295.4 0.0 8.4e-88 294.7 0.0 1.4 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.1 NM_133375.4_3 - 6.8e-07 29.0 0.0 3.5e-06 26.7 0.0 2.3 2 0 0 2 2 2 1 S1 domain Rrp44_CSD1 PF17216.1 NM_133375.4_3 - 1.5e-06 27.8 0.0 3e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain TatD_DNase PF01026.19 NM_001042552.2_2 - 5.5e-54 183.1 0.0 6.8e-54 182.8 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase TALPID3 PF15324.4 NM_001244192.1_1 - 0 2011.8 66.4 0 1992.2 64.1 2.1 2 0 0 2 2 2 2 Hedgehog signalling target SCAN PF02023.15 NM_016324.3_1 - 2.8e-38 129.5 4.0 5.8e-38 128.5 4.0 1.6 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 NM_016324.3_1 - 2.6e-28 96.7 39.5 2.4e-07 30.7 3.0 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_016324.3_1 - 1.2e-27 95.0 36.5 3.3e-08 33.5 1.2 6.4 7 0 0 7 7 6 4 Zinc-finger double domain KRAB PF01352.25 NM_016324.3_1 - 1.4e-22 78.9 0.0 3.1e-22 77.8 0.0 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_016324.3_1 - 6.6e-16 57.5 35.2 0.00095 19.7 0.3 6.5 6 0 0 6 6 6 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_016324.3_1 - 1.2e-06 28.3 15.4 0.019 15.0 2.1 4.7 3 2 2 5 5 5 3 Zinc ribbon domain XPA_N PF01286.16 NM_016324.3_1 - 5.3e-05 23.0 15.7 4.7 7.2 0.1 5.7 5 0 0 5 5 5 1 XPA protein N-terminal zf-C2H2_jaz PF12171.6 NM_016324.3_1 - 0.00012 22.1 20.8 0.0067 16.6 0.1 5.4 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_016324.3_1 - 0.00051 19.8 26.1 0.21 11.4 0.1 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger zf-met PF12874.5 NM_016324.3_1 - 0.08 13.2 0.3 0.08 13.2 0.3 5.3 6 0 0 6 6 6 0 Zinc-finger of C2H2 type ADK_lid PF05191.12 NM_016324.3_1 - 0.11 12.4 13.9 0.27 11.2 0.5 3.5 3 0 0 3 3 3 0 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 NM_016324.3_1 - 0.3 11.7 23.9 0.25 12.0 1.0 3.9 2 1 2 4 4 3 0 zinc-ribbon family LIM PF00412.20 NM_016324.3_1 - 0.95 9.6 15.0 3.2 7.9 1.2 4.1 1 1 3 4 4 4 0 LIM domain zf-trcl PF13451.4 NM_016324.3_1 - 2.2 8.1 17.1 4.7 7.0 0.0 5.1 5 0 0 5 5 5 0 Probable zinc-ribbon domain DUF2384 PF09722.8 NM_001285523.1_1 - 0.18 11.7 0.2 0.81 9.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2384) 7tm_1 PF00001.19 NM_001285523.1_3 - 9.4e-59 198.7 28.2 1.4e-58 198.1 28.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001285523.1_3 - 7.8e-09 35.1 26.8 1e-08 34.8 26.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001285523.1_3 - 9e-06 25.1 27.1 1.4e-05 24.4 27.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 NM_001285523.1_3 - 0.0016 18.1 20.5 0.0034 17.0 20.5 1.5 1 1 0 1 1 1 1 Olfactory receptor DMRT-like PF15791.3 NM_001285523.1_3 - 0.38 11.0 3.4 0.71 10.2 2.9 1.7 1 1 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 Pkinase PF00069.23 NM_181093.3_1 - 2.1e-07 30.4 0.0 7.2e-07 28.7 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_181093.3_1 - 0.00011 21.5 0.0 0.00018 20.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PWI PF01480.15 NM_021239.2_2 - 1.7e-13 50.5 0.2 3e-13 49.7 0.2 1.4 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.20 NM_021239.2_2 - 8.1e-09 35.1 0.0 1.5e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM35_C PF15793.3 NM_019054.2_1 - 4.6e-82 273.5 1.7 9.9e-82 272.4 1.7 1.6 1 0 0 1 1 1 1 Protein family FAM35, C-terminal HOOK PF05622.10 NM_001080414.3_2 - 2.7e-37 128.2 59.4 2.7e-37 128.2 59.4 4.9 1 1 3 4 4 4 1 HOOK protein LETM1 PF07766.11 NM_001300765.1_2 - 1.8e-30 106.0 4.6 2.8e-23 82.4 0.7 2.1 1 1 1 2 2 2 2 LETM1-like protein SNF PF00209.16 NM_014037.2_1 - 2.5e-120 402.5 38.1 3.4e-120 402.1 38.1 1.2 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF639 PF04842.10 NM_014037.2_1 - 0.02 14.2 0.4 0.87 8.8 0.2 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF639) Ldl_recept_a PF00057.16 NM_004631.4_1 - 3.5e-69 228.6 136.5 9.8e-12 44.8 8.5 7.9 8 0 0 8 8 8 7 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 NM_004631.4_1 - 2.8e-60 200.4 5.0 2.4e-14 53.4 0.0 5.5 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 NM_004631.4_1 - 4.4e-15 55.5 45.7 3e-08 33.7 7.2 5.2 4 0 0 4 4 4 3 Coagulation Factor Xa inhibitory site SGL PF08450.10 NM_004631.4_1 - 2.1e-07 30.7 0.1 0.011 15.2 0.0 2.3 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region cEGF PF12662.5 NM_004631.4_1 - 1.1e-06 28.3 18.8 2.2e-06 27.4 1.0 4.5 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_CA PF07645.13 NM_004631.4_1 - 1.1e-05 25.4 7.9 1.1e-05 25.4 7.9 7.3 6 3 2 9 9 9 2 Calcium-binding EGF domain DUF5050 PF16472.3 NM_004631.4_1 - 0.0006 19.0 0.0 0.001 18.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5050) TMEM154 PF15102.4 NM_004631.4_1 - 0.00079 19.2 0.2 0.0016 18.2 0.2 1.5 1 0 0 1 1 1 1 TMEM154 protein family SKG6 PF08693.8 NM_004631.4_1 - 0.0071 15.6 0.6 0.017 14.4 0.6 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain HECT PF00632.23 NM_016323.3_1 - 3.9e-64 216.9 0.9 6.3e-64 216.2 0.9 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RCC1 PF00415.16 NM_016323.3_1 - 5.3e-57 190.1 8.9 1.3e-14 54.4 0.1 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 NM_016323.3_1 - 1.4e-31 107.5 17.2 1.2e-09 37.6 0.2 5.4 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat Peptidase_S51 PF03575.15 NM_016323.3_1 - 0.036 13.6 0.0 0.51 9.8 0.0 2.3 2 0 0 2 2 2 0 Peptidase family S51 Ig_2 PF13895.4 NM_001206925.1_1 - 3.1e-08 33.7 0.3 5.4e-06 26.5 0.1 2.6 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 NM_001206925.1_1 - 3e-07 30.4 0.1 7e-07 29.2 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001206925.1_1 - 6.1e-05 23.4 0.1 0.15 12.6 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain LAX PF15681.3 NM_001206925.1_1 - 0.008 14.8 0.0 0.013 14.1 0.0 1.2 1 0 0 1 1 1 1 Lymphocyte activation family X I-set PF07679.14 NM_001206925.1_1 - 0.038 13.9 0.0 0.086 12.8 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain RGM_C PF06534.11 NM_001166287.1_2 - 3.8e-71 238.0 0.0 5.2e-71 237.5 0.0 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus RGM_N PF06535.10 NM_001166287.1_2 - 3.4e-70 235.4 1.0 5.3e-70 234.8 1.0 1.3 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus adh_short PF00106.23 NM_198707.2_3 - 8e-36 123.2 0.0 1.1e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_198707.2_3 - 5.4e-19 68.5 0.0 7.5e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_198707.2_3 - 0.001 18.9 0.0 0.004 17.0 0.0 1.8 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.8 NM_198707.2_3 - 0.043 13.0 0.0 0.062 12.5 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) UQ_con PF00179.24 NM_001012398.2_3 - 1.6e-22 79.5 0.0 2.6e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme zf-H2C2_2 PF13465.4 NM_001324353.1_1 - 1.8e-59 195.5 74.6 3.8e-08 33.3 0.5 10.4 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001324353.1_1 - 2.3e-50 166.2 70.1 6.3e-06 26.2 1.1 10.2 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001324353.1_1 - 2.7e-26 89.8 64.8 0.0049 17.5 0.4 10.4 10 0 0 10 10 10 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001324353.1_1 - 4.1e-08 33.1 50.8 0.0048 16.9 2.7 7.4 5 4 5 10 10 10 6 Zinc ribbon domain C1_4 PF07975.10 NM_001324353.1_1 - 2.3e-07 30.8 35.0 0.51 10.5 0.7 8.3 1 1 6 8 8 8 5 TFIIH C1-like domain zf-C2H2_6 PF13912.4 NM_001324353.1_1 - 4.2e-07 29.6 44.1 1.6 8.6 0.2 10.2 10 0 0 10 10 10 6 C2H2-type zinc finger XPA_N PF01286.16 NM_001324353.1_1 - 1.5e-06 27.9 42.5 2.7 8.0 0.4 9.8 10 0 0 10 10 10 4 XPA protein N-terminal CpXC PF14353.4 NM_001324353.1_1 - 1e-05 25.4 27.5 2.6 8.0 0.1 9.2 4 2 5 10 10 10 2 CpXC protein zf-C2HC_2 PF13913.4 NM_001324353.1_1 - 5.4e-05 22.9 23.6 1.4 8.8 0.0 7.9 7 0 0 7 7 7 3 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 NM_001324353.1_1 - 0.0008 19.5 22.6 7.5 6.9 0.0 8.2 8 0 0 8 8 8 2 Zinc-finger double-stranded RNA-binding Pectate_lyase22 PF14583.4 NM_001324353.1_1 - 0.021 13.4 0.0 0.054 12.0 0.0 1.6 2 0 0 2 2 2 0 Oligogalacturonate lyase DUF3268 PF11672.6 NM_001324353.1_1 - 0.14 12.3 30.0 1.3 9.3 1.3 5.2 1 1 8 9 9 9 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 NM_001324353.1_1 - 0.16 12.6 43.8 0.22 12.1 2.8 6.2 2 2 5 7 7 7 0 zinc-ribbon family HypA PF01155.17 NM_001324353.1_1 - 0.24 11.3 33.6 0.55 10.1 2.0 5.7 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-trcl PF13451.4 NM_001324353.1_1 - 8.4 6.2 29.6 14 5.6 0.1 8.5 9 0 0 9 9 9 0 Probable zinc-ribbon domain KRAB PF01352.25 NM_001324353.1_2 - 8.1e-09 34.9 0.1 5.5e-08 32.2 0.1 2.4 1 1 0 1 1 1 1 KRAB box Aminotran_5 PF00266.17 NM_016510.5_3 - 6.9e-58 196.2 0.0 2e-56 191.4 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V CarboxypepD_reg PF13620.4 NM_001004060.1_1 - 1.3e-45 153.4 8.2 2.4e-08 34.0 0.5 9.8 9 1 0 9 9 9 7 Carboxypeptidase regulatory-like domain SdrD_B PF17210.1 NM_001004060.1_1 - 3.9e-27 94.6 1.4 2.9e-05 24.1 0.0 9.4 8 1 1 9 9 9 6 SdrD B-like domain DUF2012 PF09430.8 NM_001004060.1_1 - 1.3e-22 80.0 0.6 9.1e-07 28.9 0.0 7.6 7 1 0 8 8 8 5 Protein of unknown function (DUF2012) CarbopepD_reg_2 PF13715.4 NM_001004060.1_1 - 2.7e-19 68.8 8.2 8.9e-05 22.3 0.3 9.0 9 0 0 9 9 9 5 CarboxypepD_reg-like domain fn3_3 PF14686.4 NM_001004060.1_1 - 4.9e-11 42.1 0.1 0.068 12.8 0.0 6.9 8 0 0 8 8 8 3 Polysaccharide lyase family 4, domain II DUF1416 PF07210.10 NM_001004060.1_1 - 5.1e-06 26.2 0.2 0.27 11.0 0.0 5.0 6 0 0 6 6 6 2 Protein of unknown function (DUF1416) Y_Y_Y PF07495.11 NM_001004060.1_1 - 2e-05 24.3 5.6 1.8 8.4 0.1 5.9 6 0 0 6 6 6 2 Y_Y_Y domain DUF4198 PF10670.7 NM_001004060.1_1 - 0.0001 22.7 0.6 7.3 6.8 0.1 6.4 6 1 1 7 7 7 1 Domain of unknown function (DUF4198) DUF3823 PF12866.5 NM_001004060.1_1 - 0.00045 20.0 0.3 1.2 8.8 0.0 4.0 5 0 0 5 5 5 1 Protein of unknown function (DUF3823) TTR-52 PF01060.21 NM_001004060.1_1 - 0.00091 19.7 0.1 38 4.9 0.0 5.5 6 0 0 6 6 6 0 Transthyretin-like family Dioxygenase_C PF00775.19 NM_001004060.1_1 - 0.0012 18.2 0.0 17 4.7 0.0 5.1 5 1 1 6 6 6 0 Dioxygenase MetallophosN PF16371.3 NM_001004060.1_1 - 0.0096 16.0 1.8 25 5.1 0.0 4.9 4 0 0 4 4 4 0 N terminal of Calcineurin-like phosphoesterase WD40 PF00400.30 NM_012144.3_3 - 1.1e-06 29.1 19.0 0.0029 18.3 1.7 6.2 7 0 0 7 7 7 3 WD domain, G-beta repeat Pkinase_Tyr PF07714.15 NM_000141.4_3 - 5.2e-104 347.0 0.0 7.6e-104 346.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_000141.4_3 - 8.5e-45 153.0 0.0 1.4e-44 152.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 NM_000141.4_3 - 8.3e-35 118.6 0.0 5.1e-14 52.0 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_000141.4_3 - 1.2e-34 118.6 0.1 5.7e-12 46.0 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_000141.4_3 - 2.8e-24 85.1 0.2 7.7e-10 38.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_000141.4_3 - 4.6e-23 81.1 0.0 1.1e-08 35.0 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_000141.4_3 - 3.2e-14 52.9 0.3 0.00054 19.9 0.0 4.8 4 1 0 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_000141.4_3 - 5.1e-06 26.7 0.0 0.19 12.0 0.0 3.8 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 NM_000141.4_3 - 0.013 15.4 0.1 0.6 10.1 0.0 3.3 3 1 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Kringle PF00051.16 NM_001010933.2_3 - 1.5e-56 188.5 19.2 3.8e-30 103.9 8.4 2.4 2 0 0 2 2 2 2 Kringle domain PAN_1 PF00024.24 NM_001010933.2_3 - 1.1e-10 41.2 0.7 2.2e-10 40.2 0.7 1.5 1 0 0 1 1 1 1 PAN domain TIMP PF00965.15 NM_003256.3_2 - 7.6e-66 221.2 9.2 7.6e-66 221.2 9.2 1.7 2 0 0 2 2 2 1 Tissue inhibitor of metalloproteinase Prefoldin_2 PF01920.18 NM_014260.3_3 - 4.4e-26 90.8 10.2 5.6e-26 90.4 10.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit IncA PF04156.12 NM_014260.3_3 - 1e-05 25.3 9.3 1.4e-05 24.9 9.3 1.1 1 0 0 1 1 1 1 IncA protein Prefoldin PF02996.15 NM_014260.3_3 - 0.00043 20.0 7.1 0.00069 19.4 7.1 1.3 1 0 0 1 1 1 1 Prefoldin subunit YgaB PF14182.4 NM_014260.3_3 - 0.01 16.2 10.7 0.27 11.6 1.5 2.5 2 1 0 2 2 2 0 YgaB-like protein ALIX_LYPXL_bnd PF13949.4 NM_014260.3_3 - 0.018 14.2 6.9 0.48 9.5 1.2 2.0 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV ADIP PF11559.6 NM_014260.3_3 - 0.029 14.3 1.0 0.029 14.3 1.0 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Occludin_ELL PF07303.11 NM_014260.3_3 - 0.037 14.6 5.9 0.32 11.6 0.7 2.1 2 0 0 2 2 2 0 Occludin homology domain BRE1 PF08647.9 NM_014260.3_3 - 0.086 12.8 9.9 0.2 11.6 1.5 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase OmpH PF03938.12 NM_014260.3_3 - 0.093 12.6 17.8 0.31 10.9 6.8 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Prefoldin_3 PF13758.4 NM_014260.3_3 - 0.12 12.3 3.4 0.21 11.5 2.2 2.0 1 1 0 1 1 1 0 Prefoldin subunit Spc24 PF08286.9 NM_014260.3_3 - 0.2 11.8 4.4 0.61 10.2 0.3 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 YscO PF07321.10 NM_014260.3_3 - 0.29 11.0 13.3 0.041 13.7 4.0 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO GAS PF13851.4 NM_014260.3_3 - 0.3 10.3 12.8 0.11 11.7 3.0 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.6 NM_014260.3_3 - 0.32 10.1 12.3 0.047 12.8 4.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) THOC7 PF05615.11 NM_014260.3_3 - 0.34 11.1 14.6 0.096 12.8 5.3 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 DUF1664 PF07889.10 NM_014260.3_3 - 0.41 10.5 4.3 0.3 10.9 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.9 NM_014260.3_3 - 0.51 10.6 0.2 0.51 10.6 0.2 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) FliJ PF02050.14 NM_014260.3_3 - 0.61 10.2 16.6 0.054 13.6 7.4 2.2 2 0 0 2 2 2 0 Flagellar FliJ protein DUF641 PF04859.10 NM_014260.3_3 - 0.76 10.0 7.5 0.19 11.9 0.8 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) APG6 PF04111.10 NM_014260.3_3 - 0.89 8.7 12.0 3.9 6.7 12.0 1.8 1 1 0 1 1 1 0 Autophagy protein Apg6 Taxilin PF09728.7 NM_014260.3_3 - 1.2 8.2 14.1 0.88 8.6 4.6 2.1 2 0 0 2 2 2 0 Myosin-like coiled-coil protein Fib_alpha PF08702.8 NM_014260.3_3 - 1.3 9.1 6.6 0.72 9.9 1.2 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.4 NM_014260.3_3 - 1.7 7.8 8.5 2.7 7.1 8.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TBPIP PF07106.11 NM_014260.3_3 - 1.7 8.3 9.0 0.75 9.4 0.9 2.1 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HIP1_clath_bdg PF16515.3 NM_014260.3_3 - 1.7 9.2 12.7 4.2 7.9 2.2 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DMPK_coil PF08826.8 NM_014260.3_3 - 1.9 8.5 17.0 0.74 9.8 4.7 2.2 2 0 0 2 2 2 0 DMPK coiled coil domain like EzrA PF06160.10 NM_014260.3_3 - 2 6.4 10.3 0.14 10.2 2.7 1.9 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA DUF106 PF01956.14 NM_014260.3_3 - 2 8.0 4.7 2.1 7.9 0.2 2.0 2 0 0 2 2 2 0 Integral membrane protein DUF106 Phage_GP20 PF06810.9 NM_014260.3_3 - 4.1 7.1 10.7 0.76 9.4 1.7 2.1 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF4404 PF14357.4 NM_014260.3_3 - 4.9 7.8 9.0 0.99 10.0 1.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) Spc7 PF08317.9 NM_014260.3_3 - 5.9 5.5 13.0 11 4.7 13.0 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF724 PF05266.12 NM_014260.3_3 - 6.2 6.5 9.4 27 4.4 9.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF724) GDI PF00996.16 NM_001320959.1_1 - 6e-48 163.3 0.8 1.1e-41 142.6 0.5 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor NAD_binding_8 PF13450.4 NM_001320959.1_1 - 0.092 12.9 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SE PF08491.8 NM_003129.3_3 - 1.5e-117 391.4 0.0 2e-117 391.0 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.17 NM_003129.3_3 - 3e-20 72.7 0.0 4.1e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.22 NM_003129.3_3 - 7.7e-09 35.5 0.1 0.0002 21.0 0.2 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 NM_003129.3_3 - 8e-05 22.7 0.4 0.0002 21.4 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 NM_003129.3_3 - 0.00038 20.8 0.2 0.00073 19.9 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 NM_003129.3_3 - 0.00077 18.5 1.1 0.89 8.4 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain TrkA_N PF02254.16 NM_003129.3_3 - 0.0025 17.9 0.1 0.0043 17.2 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain Pyr_redox_2 PF07992.12 NM_003129.3_3 - 0.0026 16.9 0.0 0.0042 16.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.18 NM_003129.3_3 - 0.0048 16.8 0.0 0.012 15.6 0.0 1.6 2 0 0 2 2 1 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.16 NM_003129.3_3 - 0.0073 16.1 0.1 0.012 15.4 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.14 NM_003129.3_3 - 0.0089 15.5 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.12 NM_003129.3_3 - 0.0092 14.7 0.2 0.86 8.2 0.1 2.5 2 1 1 3 3 3 1 Tryptophan halogenase NAD_Gly3P_dh_N PF01210.21 NM_003129.3_3 - 0.017 14.9 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Sacchrp_dh_NADP PF03435.16 NM_003129.3_3 - 0.018 15.2 0.1 0.033 14.3 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Thi4 PF01946.15 NM_003129.3_3 - 0.02 14.0 0.1 0.12 11.5 0.1 1.9 2 0 0 2 2 2 0 Thi4 family F420_oxidored PF03807.15 NM_003129.3_3 - 0.097 13.1 0.1 0.48 10.9 0.0 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.13 NM_003129.3_3 - 0.13 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.19 NM_003129.3_3 - 0.17 11.0 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.20 NM_003129.3_3 - 0.18 10.7 0.1 0.37 9.7 0.1 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A CBP_BcsF PF11120.6 NM_003129.3_3 - 0.18 11.7 2.1 0.24 11.3 0.3 2.2 2 0 0 2 2 1 0 Cellulose biosynthesis protein BcsF 2OG-FeII_Oxy_2 PF13532.4 NM_001001655.2_1 - 9.5e-26 91.1 0.0 1.3e-25 90.6 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily C2 PF00168.28 NM_014954.3_1 - 5.5e-48 161.4 0.0 1.6e-23 82.8 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 NM_014954.3_1 - 1.1e-35 122.3 9.6 2.3e-35 121.2 9.6 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger zf-piccolo PF05715.11 NM_014954.3_1 - 0.004 17.1 12.5 0.0096 15.9 12.5 1.7 1 0 0 1 1 1 1 Piccolo Zn-finger PI3K_C2 PF00792.22 NM_014954.3_1 - 0.053 13.4 0.0 0.61 10.0 0.0 2.2 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 OmpH PF03938.12 NM_014954.3_1 - 0.088 12.7 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PHD PF00628.27 NM_014954.3_1 - 1.5 8.7 12.6 3.7 7.4 12.6 1.8 1 0 0 1 1 1 0 PHD-finger LRR_8 PF13855.4 NM_001143758.1_1 - 9.9e-12 44.3 2.7 2.2e-10 40.0 1.2 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 NM_001143758.1_1 - 1.8e-05 24.8 4.0 0.0072 16.6 0.3 3.1 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_001143758.1_1 - 0.0029 17.0 0.1 0.0053 16.1 0.1 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.31 NM_001143758.1_1 - 0.0069 16.6 7.1 3.5 8.3 0.0 5.4 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.4 NM_001143758.1_1 - 0.023 14.6 2.6 12 6.1 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich repeat LCE PF14672.4 NM_178353.1_3 - 5.6e-21 74.8 99.4 1.8e-14 54.0 50.2 3.6 1 1 2 3 3 3 3 Late cornified envelope RUN PF02759.17 NM_001037442.3_1 - 2.7e-32 111.4 0.2 7.2e-32 110.1 0.0 1.9 2 0 0 2 2 2 1 RUN domain FYVE PF01363.19 NM_001037442.3_1 - 3.7e-05 23.6 6.3 8.3e-05 22.5 6.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger Trimer_CC PF08954.9 NM_001037442.3_1 - 0.0002 20.7 4.9 0.14 11.6 0.0 2.7 2 0 0 2 2 2 2 Trimerisation motif Reo_sigmaC PF04582.10 NM_001037442.3_1 - 0.076 12.3 11.1 0.48 9.6 3.3 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein PAXX PF15384.4 NM_001037442.3_1 - 0.47 10.0 6.7 0.83 9.2 6.7 1.3 1 0 0 1 1 1 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 XhlA PF10779.7 NM_001037442.3_1 - 1.1 9.4 10.8 3.2 7.9 3.0 3.0 2 0 0 2 2 2 0 Haemolysin XhlA DUF4407 PF14362.4 NM_001037442.3_1 - 4.8 6.3 28.2 1.3 8.2 9.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Fibrinogen_C PF00147.16 NM_031917.2_1 - 2.5e-65 220.2 4.7 3.3e-65 219.9 4.7 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain PEMT PF04191.11 NM_001267552.1_1 - 8.5e-05 22.8 0.1 0.00013 22.2 0.1 1.2 1 0 0 1 1 1 1 Phospholipid methyltransferase PEMT PF04191.11 NM_001267552.1_3 - 4e-20 72.1 1.8 4e-20 72.1 1.8 1.5 2 0 0 2 2 2 1 Phospholipid methyltransferase Ribosomal_S18 PF01084.18 NM_018135.3_1 - 7.9e-16 57.9 0.0 1.3e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 RNB PF00773.17 NM_001128226.2_3 - 4.6e-103 344.8 0.5 6.3e-103 344.4 0.5 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.1 NM_001128226.2_3 - 5.8e-13 48.7 0.0 9.6e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.1 NM_001128226.2_3 - 1.8e-11 43.7 0.3 3.3e-11 42.8 0.3 1.4 1 0 0 1 1 1 1 S1 domain PIN_4 PF13638.4 NM_001128226.2_3 - 1.4e-05 25.3 0.1 0.00011 22.3 0.0 2.2 2 0 0 2 2 2 1 PIN domain SSXRD PF09514.8 NM_005635.3_2 - 1.6e-16 59.4 0.6 5.1e-16 57.8 0.6 1.9 1 0 0 1 1 1 1 SSXRD motif KRAB PF01352.25 NM_005635.3_2 - 0.00041 19.8 0.0 0.00066 19.2 0.0 1.3 1 0 0 1 1 1 1 KRAB box LIM PF00412.20 NM_003302.2_3 - 1.4e-31 108.3 21.6 4.4e-13 49.1 1.4 3.2 3 0 0 3 3 3 3 LIM domain Guanylate_cyc PF00211.18 NM_000906.3_2 - 3.7e-71 238.4 0.0 2.8e-70 235.5 0.0 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.26 NM_000906.3_2 - 1.9e-48 165.2 0.0 2.8e-48 164.7 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Pkinase_Tyr PF07714.15 NM_000906.3_2 - 2.9e-38 131.5 0.0 4.5e-38 130.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_000906.3_2 - 2.7e-29 102.2 0.0 4.2e-29 101.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HNOBA PF07701.12 NM_000906.3_2 - 0.00017 21.0 0.9 0.00026 20.4 0.9 1.2 1 0 0 1 1 1 1 Heme NO binding associated Methyltransf_25 PF13649.4 NM_024770.4_2 - 6.4e-11 42.7 0.0 1.1e-10 42.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_024770.4_2 - 4.6e-10 40.0 0.0 8.7e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 NM_024770.4_2 - 2.1e-09 37.4 0.0 3.9e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_024770.4_2 - 7.8e-09 35.9 0.0 1.4e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_024770.4_2 - 0.00012 21.8 0.0 0.00019 21.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RRM_1 PF00076.20 NM_014469.4_2 - 4.4e-22 77.6 0.1 6.6e-22 77.0 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 NM_014469.4_2 - 9.2e-18 63.9 15.7 9.2e-18 63.9 15.7 6.7 5 2 1 6 6 6 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 NM_014469.4_2 - 0.0047 16.9 0.0 0.0089 16.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif FH2 PF02181.21 NM_001318202.1_2 - 6.8e-91 305.0 0.0 8.8e-91 304.7 0.0 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Hairy_orange PF07527.11 NM_001318202.1_2 - 0.024 14.7 4.3 1.2 9.2 0.5 2.9 2 0 0 2 2 2 0 Hairy Orange Neur_chan_LBD PF02931.21 NM_001166061.1_2 - 1.5e-52 178.1 0.1 1.9e-52 177.7 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_001166061.1_2 - 5.8e-07 29.7 0.2 1.1e-06 28.7 0.2 1.5 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_memb PF02932.14 NM_001166061.1_3 - 0.0003 20.8 0.0 0.00046 20.2 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region TCRP1 PF14944.4 NM_001321745.1_3 - 6.8e-106 353.6 64.2 6e-84 281.7 42.1 2.1 1 1 1 2 2 2 2 Tongue Cancer Chemotherapy Resistant Protein 1 Ets PF00178.20 NM_001243428.1_2 - 1.3e-35 121.5 0.4 2.9e-35 120.5 0.4 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 NM_001243428.1_2 - 9.5e-26 89.5 0.0 2.4e-25 88.2 0.0 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain tRNA_anti_2 PF13742.4 NM_001243428.1_3 - 0.13 12.4 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain La PF05383.15 NM_199190.2_2 - 1.4e-16 60.2 0.1 2.5e-16 59.3 0.1 1.5 1 0 0 1 1 1 1 La domain FANCA_interact PF15751.3 NM_001256945.1_2 - 2.5e-25 88.9 9.0 2.5e-25 88.9 9.0 2.0 2 0 0 2 2 2 1 FAAP20 FANCA interaction domain UBZ_FAAP20 PF15750.3 NM_001256945.1_2 - 0.00015 21.5 0.5 0.0003 20.5 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin-binding zinc-finger TRIC PF05197.11 NM_018112.2_2 - 4.4e-78 261.1 2.6 6.8e-78 260.4 2.6 1.3 1 0 0 1 1 1 1 TRIC channel MAD PF05557.11 NM_001304524.1_1 - 1.2e-238 793.7 65.9 1.5e-238 793.4 65.9 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein DUF4200 PF13863.4 NM_001304524.1_1 - 0.0018 18.5 4.1 0.0018 18.5 4.1 5.6 4 2 0 4 4 4 1 Domain of unknown function (DUF4200) TSC22 PF01166.16 NM_001304524.1_1 - 0.02 15.0 2.1 0.02 15.0 2.1 7.6 7 2 2 9 9 9 0 TSC-22/dip/bun family Spc7 PF08317.9 NM_001304524.1_1 - 0.67 8.6 75.7 0.26 10.0 15.4 5.0 2 2 3 5 5 5 0 Spc7 kinetochore protein MAD PF05557.11 NM_001304524.1_3 - 1.5e-15 56.5 8.2 1.9e-15 56.1 8.2 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein ZapB PF06005.10 NM_001304524.1_3 - 2.1 8.7 12.5 3.5 8.0 12.5 1.2 1 0 0 1 1 1 0 Cell division protein ZapB FIIND PF13553.4 NM_033006.3_1 - 5.2e-103 343.6 0.1 2.7e-102 341.3 0.0 2.0 2 0 0 2 2 2 1 Function to find NACHT PF05729.10 NM_033006.3_1 - 1.6e-46 158.1 0.1 1e-45 155.5 0.0 2.2 2 0 0 2 2 2 1 NACHT domain CARD PF00619.19 NM_033006.3_1 - 2.5e-19 68.9 0.6 6.5e-19 67.6 0.6 1.8 1 0 0 1 1 1 1 Caspase recruitment domain PYRIN PF02758.14 NM_033006.3_1 - 1.9e-16 59.9 0.1 4.8e-16 58.6 0.1 1.7 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain LRR_6 PF13516.4 NM_033006.3_1 - 1.6e-14 52.5 14.7 4.7e-06 26.1 0.2 5.5 5 0 0 5 5 5 3 Leucine Rich repeat AAA_16 PF13191.4 NM_033006.3_1 - 9.6e-07 29.2 0.0 1e-05 25.8 0.0 2.6 1 1 0 1 1 1 1 AAA ATPase domain LRR_4 PF12799.5 NM_033006.3_1 - 6.2e-05 23.1 8.9 1.8 9.0 0.3 4.7 2 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_033006.3_1 - 0.0018 17.9 3.8 3.5 7.3 0.1 3.6 3 0 0 3 3 3 2 Leucine rich repeat NB-ARC PF00931.20 NM_033006.3_1 - 0.0072 15.2 0.0 0.014 14.3 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_30 PF13604.4 NM_033006.3_1 - 0.01 15.4 0.0 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain LRR_1 PF00560.31 NM_033006.3_1 - 0.012 15.8 9.9 1.2 9.8 0.2 5.5 5 1 0 5 5 4 0 Leucine Rich Repeat AAA_22 PF13401.4 NM_033006.3_1 - 0.077 13.1 0.1 0.35 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.12 NM_033006.3_1 - 0.096 12.5 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.10 NM_033006.3_1 - 0.098 11.8 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Herpes_U30 PF04523.11 NM_033006.3_1 - 0.16 9.7 0.9 0.27 9.0 0.3 1.6 1 1 1 2 2 2 0 Herpes virus tegument protein U30 Birna_VP5 PF03042.12 NM_033006.3_1 - 1.4 8.8 7.0 0.054 13.4 0.4 2.0 2 0 0 2 2 1 0 Birnavirus VP5 protein TPR_1 PF00515.26 NM_001256750.1_2 - 3.6e-21 73.9 0.6 0.0001 21.8 0.0 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001256750.1_2 - 1.3e-18 65.4 2.3 0.0013 18.6 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001256750.1_2 - 6.6e-15 53.9 0.2 0.013 15.6 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001256750.1_2 - 2.1e-11 43.2 0.3 0.0087 15.6 0.0 4.3 3 2 1 4 4 4 3 TPR repeat TPR_17 PF13431.4 NM_001256750.1_2 - 5.2e-11 42.0 2.9 0.043 14.1 0.3 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001256750.1_2 - 2.3e-10 40.3 2.4 0.016 15.8 0.4 5.0 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001256750.1_2 - 1.1e-09 38.5 4.2 0.0069 16.7 1.4 4.2 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001256750.1_2 - 6.6e-09 35.7 0.9 0.0067 16.4 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001256750.1_2 - 2.3e-08 34.5 4.2 2.8e-05 24.6 0.3 3.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001256750.1_2 - 5.3e-07 29.7 2.6 0.023 14.9 0.5 4.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.4 NM_001256750.1_2 - 9.2e-07 29.0 1.1 0.00089 19.4 0.5 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001256750.1_2 - 6.5e-05 22.5 0.8 5 7.3 0.1 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001256750.1_2 - 9.3e-05 22.4 1.5 0.085 12.9 0.9 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 NM_001256750.1_2 - 0.00019 21.8 0.3 33 5.3 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.7 NM_001256750.1_2 - 1.4 8.3 5.2 51 3.3 0.8 3.4 3 0 0 3 3 3 0 SHNi-TPR TPR_10 PF13374.4 NM_001256750.1_2 - 5.6 6.8 7.0 26 4.7 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat LIM PF00412.20 NM_001257963.1_2 - 9.9e-13 48.0 3.1 9.9e-13 48.0 3.1 2.1 2 0 0 2 2 2 1 LIM domain DUF4749 PF15936.3 NM_001257963.1_2 - 7e-10 39.8 0.0 1.3e-09 39.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) Lar_restr_allev PF14354.4 NM_001257963.1_2 - 0.21 11.9 2.0 0.6 10.4 2.0 1.8 1 0 0 1 1 1 0 Restriction alleviation protein Lar RWD PF05773.20 NM_022453.2_2 - 4e-19 68.9 0.0 8e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 RWD domain zf-RING_11 PF17123.3 NM_022453.2_2 - 6.9e-06 25.6 8.6 6.9e-06 25.6 8.6 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.4 NM_022453.2_2 - 9.8e-06 25.6 11.9 0.00012 22.1 12.0 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 NM_022453.2_2 - 0.018 14.8 9.1 0.15 11.8 9.3 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_022453.2_2 - 0.039 13.8 13.3 0.16 11.8 13.3 2.0 1 1 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.5 NM_022453.2_2 - 0.054 13.7 6.7 0.086 13.0 3.9 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain Sin_N PF04801.11 NM_022453.2_2 - 0.057 12.5 1.8 0.097 11.7 1.8 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region zf-C3HC4_2 PF13923.4 NM_022453.2_2 - 0.089 12.5 11.4 0.038 13.7 6.4 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_022453.2_2 - 0.099 12.5 9.7 0.12 12.3 3.1 2.8 3 0 0 3 3 3 0 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_022453.2_2 - 0.67 9.7 8.9 13 5.6 4.8 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 NM_022453.2_2 - 1.4 8.9 7.5 0.95 9.4 4.1 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Motile_Sperm PF00635.24 NM_023948.4_2 - 1.4e-14 53.7 0.0 2e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain dsrm PF00035.24 NM_001164380.1_3 - 6.8e-45 151.5 2.6 6.8e-13 49.0 0.1 4.6 4 0 0 4 4 4 4 Double-stranded RNA binding motif Staufen_C PF16482.3 NM_001164380.1_3 - 2.7e-16 59.5 4.8 1.2e-14 54.3 0.2 4.9 6 1 0 6 6 6 1 Staufen C-terminal domain DND1_DSRM PF14709.5 NM_001164380.1_3 - 2.9e-05 24.1 4.6 1.2 9.3 0.2 5.0 4 2 0 4 4 4 2 double strand RNA binding domain from DEAD END PROTEIN 1 MCM PF00493.21 NM_001281521.1_3 - 5.1e-115 384.0 0.0 7.3e-115 383.4 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 NM_001281521.1_3 - 7.9e-25 87.0 0.2 1.5e-24 86.2 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.19 NM_001281521.1_3 - 1.1e-07 31.3 0.0 0.00012 21.4 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 NM_001281521.1_3 - 3.4e-07 30.2 0.0 7.4e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.9 NM_001281521.1_3 - 0.0002 21.1 0.0 0.00048 19.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.27 NM_001281521.1_3 - 0.058 13.7 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.13 NM_001281521.1_3 - 0.072 12.9 0.1 2.3 8.0 0.1 2.5 2 0 0 2 2 2 0 NTPase AAA_22 PF13401.4 NM_001281521.1_3 - 0.076 13.2 0.0 0.49 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.4 NM_001281521.1_3 - 0.09 13.0 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.16 NM_001281521.1_3 - 0.11 11.7 0.0 0.44 9.7 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family COX3 PF00510.16 NM_001033930.2_2 - 2.4 7.8 5.7 1.5 8.5 1.3 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase subunit III ubiquitin PF00240.21 NM_001033930.2_3 - 2e-33 113.8 0.3 2.9e-33 113.3 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.15 NM_001033930.2_3 - 7.1e-32 108.9 12.3 1.7e-31 107.7 12.3 1.7 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.6 NM_001033930.2_3 - 1.6e-15 56.5 0.4 2.3e-15 56.0 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 NM_001033930.2_3 - 0.00018 21.7 0.1 0.00035 20.8 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain Toxin_18 PF08087.9 NM_001033930.2_3 - 0.073 12.9 0.4 0.073 12.9 0.4 3.3 3 0 0 3 3 3 0 Conotoxin O-superfamily Rad60-SLD_2 PF13881.4 NM_001033930.2_3 - 0.14 12.1 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like zf-H2C2_2 PF13465.4 NM_001323662.1_1 - 2.1e-27 94.2 57.8 1.3e-07 31.6 5.1 7.9 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001323662.1_1 - 5.5e-23 80.0 66.2 0.00021 21.5 5.0 8.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001323662.1_1 - 9.8e-13 47.6 62.2 0.058 14.1 4.4 8.1 7 0 0 7 7 7 7 C2H2-type zinc finger zf-Di19 PF05605.10 NM_001323662.1_1 - 2.6e-07 30.7 25.9 3.2e-07 30.4 1.4 3.9 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 NM_001323662.1_1 - 3e-07 30.4 47.4 0.021 15.0 1.7 7.8 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001323662.1_1 - 3.3e-05 24.0 52.7 0.044 14.0 2.4 7.2 7 0 0 7 7 7 5 Zinc-finger of C2H2 type Homeobox PF00046.27 NM_001323662.1_1 - 4.2e-05 23.1 0.0 0.0001 21.9 0.0 1.6 1 0 0 1 1 1 1 Homeobox domain zf-C2H2_6 PF13912.4 NM_001323662.1_1 - 0.0066 16.2 58.8 1 9.3 0.8 7.7 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_9 PF16293.3 NM_001323662.1_1 - 1.8 8.4 14.9 7.9 6.3 0.1 4.8 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) Zn-ribbon_8 PF09723.8 NM_001323662.1_1 - 2.8 8.0 22.1 0.17 11.9 2.9 4.4 4 0 0 4 4 4 0 Zinc ribbon domain zf-C2H2_2 PF12756.5 NM_001323662.1_1 - 8.6 6.6 42.8 0.068 13.4 1.1 6.1 2 2 3 5 5 5 0 C2H2 type zinc-finger (2 copies) BTB PF00651.29 NM_001318722.1_1 - 2.4e-25 88.8 2.2 4.2e-25 88.0 2.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.4 NM_001318722.1_1 - 1.1e-17 63.5 1.0 1.5e-05 24.9 0.0 4.8 3 1 1 4 4 4 3 Kelch motif BACK PF07707.13 NM_001318722.1_1 - 2e-11 43.8 0.9 1.4e-09 37.9 0.2 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.13 NM_001318722.1_1 - 2.8e-08 33.3 0.4 0.0015 18.3 0.2 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.23 NM_001318722.1_1 - 3.5e-06 26.3 1.4 0.023 14.1 0.0 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.4 NM_001318722.1_1 - 0.0023 17.7 1.0 0.38 10.6 0.0 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain TMEM135_C_rich PF15982.3 NM_001168724.1_2 - 1.1e-66 223.2 1.4 1.1e-66 223.2 1.4 1.8 2 0 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 Tim17 PF02466.17 NM_001168724.1_2 - 2e-08 34.4 0.2 9.3e-07 29.0 0.1 2.3 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Mtc PF03820.15 NM_001322982.1_1 - 2.4e-127 424.1 2.9 3.3e-127 423.7 2.9 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier Mtc PF03820.15 NM_001322982.1_3 - 6.8e-13 48.2 0.1 9e-13 47.8 0.1 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier 7tm_4 PF13853.4 NM_001004459.1_1 - 4.2e-55 187.3 19.9 5.1e-55 187.0 19.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004459.1_1 - 1.1e-19 70.6 24.3 5.4e-19 68.3 24.3 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001004459.1_1 - 2.9e-06 26.7 23.2 7.4e-06 25.4 23.2 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Ank_2 PF12796.5 NM_001320874.1_3 - 3.4e-144 469.7 48.7 3.3e-17 62.7 0.1 11.7 2 2 9 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.28 NM_001320874.1_3 - 9e-133 427.4 66.3 9.3e-07 28.9 0.1 23.4 21 1 2 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 NM_001320874.1_3 - 6.9e-119 386.7 50.7 5.7e-11 42.6 0.4 17.2 6 3 12 19 19 19 18 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001320874.1_3 - 5.9e-112 363.6 45.9 3.3e-11 43.1 0.0 16.6 4 4 16 20 20 20 20 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001320874.1_3 - 3.9e-107 337.0 36.6 8.7e-05 22.5 0.0 24.2 24 0 0 24 24 24 22 Ankyrin repeat ZU5 PF00791.18 NM_001320874.1_3 - 9.4e-33 112.3 0.8 5.7e-27 93.8 0.0 2.5 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 NM_001320874.1_3 - 3.8e-21 74.9 0.0 7.6e-21 73.9 0.0 1.6 1 0 0 1 1 1 1 Death domain Ion_trans PF00520.29 NM_001081676.1_1 - 5.8e-257 847.6 103.8 1.6e-82 276.3 13.9 4.3 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.11 NM_001081676.1_1 - 1.1e-55 188.8 1.9 1.1e-55 188.8 1.9 2.8 3 1 0 3 3 3 1 Sodium ion transport-associated Na_trans_cytopl PF11933.6 NM_001081676.1_1 - 6.5e-48 163.3 17.7 5.7e-41 140.6 11.9 2.7 1 1 1 2 2 2 2 Cytoplasmic domain of voltage-gated Na+ ion channel PKD_channel PF08016.10 NM_001081676.1_1 - 5.4e-06 25.2 83.3 0.00019 20.1 0.3 9.5 6 4 4 10 10 10 5 Polycystin cation channel GPHH PF16905.3 NM_001081676.1_1 - 1.2e-05 24.9 0.0 2.6e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated ATP-synt_B PF00430.16 NM_001081676.1_1 - 0.0012 18.8 5.2 0.0048 16.9 5.2 2.0 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) Tmemb_9 PF05434.9 NM_001081676.1_1 - 0.081 12.6 1.6 19 5.0 0.1 3.2 2 0 0 2 2 2 0 TMEM9 IQ PF00612.25 NM_001081676.1_1 - 0.17 11.6 0.3 0.42 10.4 0.3 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif DNA_pol_E_B PF04042.14 NM_001127218.2_2 - 1.7e-49 167.9 0.1 2.9e-49 167.2 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B CH PF00307.29 NM_001243385.1_1 - 6.4e-33 113.1 3.5 3.6e-17 62.4 0.7 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_001243385.1_1 - 0.011 15.4 0.1 1.4 8.6 0.0 2.6 2 0 0 2 2 2 0 CAMSAP CH domain CH_2 PF06294.9 NM_001243385.1_1 - 0.012 15.6 0.1 0.4 10.7 0.0 2.3 2 0 0 2 2 2 0 CH-like domain in sperm protein 4HBT PF03061.20 NM_001243385.1_1 - 0.12 12.6 0.1 0.26 11.6 0.1 1.5 1 0 0 1 1 1 0 Thioesterase superfamily LRR_4 PF12799.5 NM_001146344.2_3 - 0.065 13.5 14.2 1.5 9.2 0.3 5.4 3 1 5 8 8 8 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001146344.2_3 - 2.1 9.0 12.3 6.9 7.4 0.1 5.9 6 1 0 6 6 6 0 Leucine Rich Repeat Lactamase_B_2 PF12706.5 NM_001319946.1_1 - 0.098 12.0 0.6 0.15 11.4 0.6 1.2 1 0 0 1 1 1 0 Beta-lactamase superfamily domain DRMBL PF07522.12 NM_001319946.1_3 - 4.5e-10 39.6 1.5 1.3e-08 34.9 1.5 2.4 1 1 0 1 1 1 1 DNA repair metallo-beta-lactamase RMMBL PF07521.10 NM_001319946.1_3 - 0.03 14.1 0.1 0.059 13.2 0.1 1.4 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain zf-H2C2_2 PF13465.4 NM_014569.3_3 - 6.2e-64 209.6 104.5 1.9e-09 37.4 1.5 15.8 15 0 0 15 15 15 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_014569.3_3 - 3.5e-49 162.5 119.2 4e-05 23.7 0.3 14.3 14 0 0 14 14 13 12 Zinc finger, C2H2 type SCAN PF02023.15 NM_014569.3_3 - 1.4e-40 136.9 5.4 3.3e-40 135.7 5.4 1.7 1 0 0 1 1 1 1 SCAN domain zf-C2H2_4 PF13894.4 NM_014569.3_3 - 5.1e-21 73.4 113.6 0.0057 17.2 0.2 14.8 14 0 0 14 14 14 12 C2H2-type zinc finger KRAB PF01352.25 NM_014569.3_3 - 1.2e-13 50.3 0.0 3.3e-13 48.9 0.0 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_014569.3_3 - 6.3e-07 29.1 91.7 0.025 14.4 0.1 14.3 14 0 0 14 14 14 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_014569.3_3 - 0.00029 20.8 56.7 0.025 14.6 1.6 8.7 6 3 4 10 10 10 6 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_014569.3_3 - 0.0044 16.6 1.1 0.0044 16.6 1.1 11.0 12 0 0 12 12 12 3 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_014569.3_3 - 0.059 14.0 47.7 3 8.5 1.8 7.5 3 3 4 8 8 8 0 zinc-ribbon family DUF3268 PF11672.6 NM_014569.3_3 - 3.5 7.9 37.2 2.4 8.4 1.0 6.3 6 0 0 6 6 6 0 zinc-finger-containing domain ADK_lid PF05191.12 NM_014569.3_3 - 6.8 6.7 40.7 0.31 10.9 1.2 8.1 6 1 3 9 9 9 0 Adenylate kinase, active site lid FYVE PF01363.19 NM_014569.3_3 - 6.9 6.8 60.7 0.064 13.3 3.7 8.0 3 3 2 5 5 4 0 FYVE zinc finger PDGF PF00341.15 NM_001025368.2_1 - 3.3e-26 91.3 5.3 3.3e-26 91.3 5.3 1.9 2 0 0 2 2 2 1 PDGF/VEGF domain VEGF_C PF14554.4 NM_001025368.2_1 - 4.6e-26 90.5 25.1 1.1e-25 89.3 25.1 1.7 1 0 0 1 1 1 1 VEGF heparin-binding domain TCR PF03638.13 NM_001288996.1_3 - 5.4e-23 80.9 54.8 2.7e-12 46.6 22.9 2.8 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.3 NM_001288996.1_3 - 0.76 9.8 44.5 1.2 9.1 17.2 2.7 2 0 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 Peptidase_C97 PF05903.12 NM_001297746.1_3 - 5.3e-27 94.4 1.8 3.1e-22 78.9 0.0 2.2 1 1 1 2 2 2 2 PPPDE putative peptidase domain RRM_1 PF00076.20 NM_080594.3_2 - 1.5e-17 63.1 0.0 2.2e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 NM_080594.3_2 - 0.0016 18.3 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 Limkain b1 RRM_7 PF16367.3 NM_080594.3_2 - 0.0018 18.2 0.0 0.0033 17.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.4 NM_080594.3_2 - 0.013 15.3 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.9 NM_080594.3_2 - 0.017 15.0 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif RRM_5 PF13893.4 NM_080594.3_2 - 0.017 14.6 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_080594.3_2 - 0.045 13.5 0.0 0.076 12.8 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Macoilin PF09726.7 NM_080594.3_2 - 0.048 12.1 26.6 0.084 11.3 26.6 1.3 1 0 0 1 1 1 0 Transmembrane protein LAP1C PF05609.10 NM_080594.3_2 - 1.2 8.1 18.3 1.7 7.6 18.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Pkinase PF00069.23 NM_001287135.1_3 - 6.3e-67 225.6 0.0 8.1e-67 225.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001287135.1_3 - 3.3e-31 108.4 0.0 4.7e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001287135.1_3 - 0.012 14.9 0.1 0.025 13.8 0.0 1.5 2 0 0 2 2 2 0 Kinase-like Ion_trans PF00520.29 NM_001293306.2_1 - 3e-251 828.8 93.6 4.7e-77 258.4 8.8 4.2 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.11 NM_001293306.2_1 - 8.2e-56 189.1 0.1 8.2e-56 189.1 0.1 2.6 3 0 0 3 3 3 1 Sodium ion transport-associated PKD_channel PF08016.10 NM_001293306.2_1 - 3.1e-12 45.8 84.1 7.9e-06 24.7 1.2 10.6 6 4 4 10 10 10 7 Polycystin cation channel GPHH PF16905.3 NM_001293306.2_1 - 1.5e-05 24.6 0.0 3.6e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Na_trans_cytopl PF11933.6 NM_001293306.2_1 - 3.4e-05 23.7 1.1 0.00042 20.1 0.7 2.4 2 0 0 2 2 2 1 Cytoplasmic domain of voltage-gated Na+ ion channel DUF4363 PF14276.4 NM_001293306.2_1 - 6.7 6.6 6.3 22 5.0 0.3 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) WD40 PF00400.30 NM_173636.4_2 - 8.5e-33 111.7 23.1 0.0046 17.6 0.0 12.7 12 0 0 12 12 12 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_173636.4_2 - 1.4e-15 57.2 0.5 7.9e-05 22.7 0.0 6.9 4 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_173636.4_2 - 0.0024 17.6 0.2 0.098 12.4 0.1 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A DUF5046 PF16465.3 NM_173636.4_2 - 0.0052 16.1 0.5 0.054 12.8 0.3 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF5046) ARID PF01388.19 NM_001319092.1_2 - 1.8e-15 57.2 0.0 3.3e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Crystall PF00030.17 NM_001308292.1_2 - 3.8e-31 107.0 0.1 5.6e-31 106.5 0.1 1.2 1 0 0 1 1 1 1 Beta/Gamma crystallin FBA PF04300.11 NM_183412.2_1 - 4.8e-09 36.2 0.0 7.1e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 F-box associated region F-box-like PF12937.5 NM_183412.2_1 - 3.8e-08 33.0 4.8 8.8e-08 31.8 4.8 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_183412.2_1 - 1.2e-07 31.3 4.1 3.5e-07 29.8 4.1 1.8 1 0 0 1 1 1 1 F-box domain FBA PF04300.11 NM_183412.2_2 - 1.5e-31 109.5 0.0 2.2e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 F-box associated region Cadherin PF00028.15 NM_001291285.1_1 - 0 2073.7 70.4 1.6e-25 89.2 0.7 34.5 34 0 0 34 34 34 34 Cadherin domain Cadherin_2 PF08266.10 NM_001291285.1_1 - 2.3e-50 168.2 0.0 0.017 14.8 0.0 25.5 29 1 0 29 29 29 9 Cadherin-like Laminin_G_2 PF02210.22 NM_001291285.1_1 - 3.8e-37 127.5 0.2 4.9e-18 65.8 0.0 3.5 3 0 0 3 3 2 2 Laminin G domain Laminin_G_1 PF00054.21 NM_001291285.1_1 - 4.6e-32 110.9 0.0 3.2e-16 59.6 0.0 3.3 3 0 0 3 3 3 2 Laminin G domain Cadherin_3 PF16184.3 NM_001291285.1_1 - 4.3e-23 81.3 75.0 0.17 11.8 0.1 26.8 28 1 1 29 29 29 6 Cadherin-like EGF PF00008.25 NM_001291285.1_1 - 4.5e-22 77.9 98.3 3.2e-06 27.2 8.9 8.1 7 1 0 7 7 7 6 EGF-like domain EGF_CA PF07645.13 NM_001291285.1_1 - 5.6e-11 42.3 23.2 2.2e-07 30.8 5.7 7.0 5 2 2 7 7 5 2 Calcium-binding EGF domain hEGF PF12661.5 NM_001291285.1_1 - 9.7e-07 29.1 92.8 0.0042 17.6 8.6 8.8 9 0 0 9 9 8 5 Human growth factor-like EGF EGF_2 PF07974.11 NM_001291285.1_1 - 0.0013 18.9 95.9 0.37 11.1 10.1 7.1 6 1 0 6 6 6 3 EGF-like domain Motile_Sperm PF00635.24 NM_001291285.1_1 - 0.12 12.1 0.0 1.6 8.5 0.0 2.9 2 0 0 2 2 2 0 MSP (Major sperm protein) domain SusE PF14292.4 NM_001291285.1_1 - 9.4 6.5 19.9 0.18 12.1 0.7 7.9 10 0 0 10 10 9 0 SusE outer membrane protein ADH_zinc_N PF00107.24 NM_175907.5_3 - 8.4e-27 93.5 0.0 1.4e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 NM_175907.5_3 - 3e-10 41.1 0.0 4.8e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 NM_175907.5_3 - 3.6e-06 26.7 0.0 2.1e-05 24.2 0.0 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.3 NM_175907.5_3 - 0.015 15.0 0.1 0.038 13.8 0.0 1.6 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase CENP-F_leu_zip PF10473.7 NM_001164537.1_3 - 0.13 12.1 29.3 0.24 11.3 0.5 4.5 4 1 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin PF00261.18 NM_001164537.1_3 - 0.5 9.6 18.8 0.16 11.2 1.2 3.4 4 0 0 4 4 4 0 Tropomyosin SbcD_C PF12320.6 NM_001164537.1_3 - 0.77 10.0 5.6 16 5.7 1.6 2.7 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain ADIP PF11559.6 NM_001164537.1_3 - 4.3 7.3 26.9 1.2 9.1 3.1 4.6 5 0 0 5 5 5 0 Afadin- and alpha -actinin-Binding eIF-5a PF01287.18 NM_020390.5_2 - 1.9e-25 88.6 0.1 3e-25 88.0 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.10 NM_020390.5_2 - 0.12 12.3 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain Runt PF00853.17 NM_001122607.1_1 - 4.2e-73 242.9 0.1 6.3e-73 242.3 0.1 1.2 1 0 0 1 1 1 1 Runt domain Arm PF00514.21 NM_001304971.1_3 - 3.8e-44 147.3 7.0 2.1e-10 40.2 0.0 8.0 8 0 0 8 8 8 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 NM_001304971.1_3 - 5.6e-07 29.7 0.1 0.0095 16.2 0.0 2.9 2 0 0 2 2 2 2 HEAT repeats HEAT_EZ PF13513.4 NM_001304971.1_3 - 0.00024 21.3 1.0 1.9 8.9 0.0 4.8 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.20 NM_001304971.1_3 - 0.00026 20.8 2.8 0.83 9.9 0.0 4.4 4 0 0 4 4 4 1 HEAT repeat Mtc PF03820.15 NM_001322978.1_2 - 6.7e-13 48.2 0.1 9e-13 47.8 0.1 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier Mtc PF03820.15 NM_001322978.1_3 - 2.4e-127 424.2 2.9 3.3e-127 423.7 2.9 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier zf-H2C2_2 PF13465.4 NM_001039615.3_3 - 1.2e-34 117.0 54.6 7.6e-08 32.3 3.8 9.9 10 0 0 10 10 10 7 Zinc-finger double domain KRAB PF01352.25 NM_001039615.3_3 - 2e-22 78.4 0.2 3.9e-22 77.5 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2 PF00096.24 NM_001039615.3_3 - 2.6e-16 58.9 62.5 2e-05 24.6 3.3 8.6 8 0 0 8 8 8 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001039615.3_3 - 1.2e-05 25.6 74.8 0.0084 16.7 2.2 10.0 9 1 1 10 10 10 4 C2H2-type zinc finger GAGA PF09237.9 NM_001039615.3_3 - 0.16 11.7 10.4 3.1 7.5 0.3 3.9 2 1 1 3 3 3 0 GAGA factor zf-CCHC_2 PF13696.4 NM_001039615.3_3 - 1.7 8.4 23.9 4.7 7.0 0.4 5.5 5 0 0 5 5 5 0 Zinc knuckle WD40 PF00400.30 NM_182758.3_1 - 2e-10 40.9 10.2 0.16 12.7 0.1 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_182758.3_1 - 2.6e-06 27.5 0.3 0.0016 18.5 0.0 4.8 5 2 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_182758.3_1 - 0.0016 17.0 0.3 1.7 7.0 0.0 2.7 2 1 1 3 3 3 2 Nucleoporin Nup120/160 DUF4499 PF14934.4 NM_001270371.1_3 - 5e-32 110.0 4.6 1.1e-31 108.9 4.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) Trypsin_2 PF13365.4 NM_001321727.1_3 - 4.6e-27 95.6 1.3 1.5e-26 93.9 0.8 2.2 2 0 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.24 NM_001321727.1_3 - 1.6e-10 41.0 0.0 2.9e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.4 NM_001321727.1_3 - 0.0011 19.1 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.22 NM_001321727.1_3 - 0.048 13.9 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Peptidase_S46 PF10459.7 NM_001321727.1_3 - 0.24 9.9 0.2 0.99 7.8 0.0 1.8 2 0 0 2 2 2 0 Peptidase S46 Pkinase_Tyr PF07714.15 NM_002031.2_1 - 6.5e-97 323.7 0.0 8.2e-97 323.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_002031.2_1 - 9.1e-51 172.6 0.0 1.3e-50 172.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 NM_002031.2_1 - 8.9e-25 86.4 0.3 2.3e-24 85.1 0.3 1.7 2 0 0 2 2 2 1 SH2 domain SH3_1 PF00018.26 NM_002031.2_1 - 6.5e-13 47.9 0.0 1.2e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_002031.2_1 - 1.8e-09 37.0 0.0 3.1e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_002031.2_1 - 1.3e-08 34.4 0.0 2.5e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Kdo PF06293.12 NM_002031.2_1 - 0.014 14.6 0.1 0.024 13.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_002031.2_1 - 0.017 14.9 0.0 4.2 7.1 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Arfaptin PF06456.11 NM_001287431.1_3 - 1.1e-81 273.6 9.8 1.4e-81 273.3 9.8 1.1 1 0 0 1 1 1 1 Arfaptin-like domain TPR_MLP1_2 PF07926.10 NM_001287431.1_3 - 0.98 9.4 4.5 14 5.6 0.2 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein GTP_EFTU PF00009.25 NM_032380.4_3 - 2e-66 223.1 0.0 3.5e-66 222.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.4 NM_032380.4_3 - 2.7e-27 94.5 0.0 5.6e-27 93.5 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.22 NM_032380.4_3 - 3.6e-23 81.3 0.0 7.8e-23 80.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.16 NM_032380.4_3 - 3.7e-11 42.7 0.0 8.1e-11 41.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.23 NM_032380.4_3 - 2.3e-08 34.2 0.0 4.4e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.3 NM_032380.4_3 - 1.2e-06 28.2 0.0 2.6e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.21 NM_032380.4_3 - 0.00036 20.5 0.0 0.00076 19.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AvrPtoB_bdg PF16847.3 NM_032380.4_3 - 0.0033 17.7 0.0 0.04 14.3 0.0 2.6 3 0 0 3 3 3 1 Avirulence AvrPtoB, BAK1-binding domain AIG1 PF04548.14 NM_032380.4_3 - 0.048 12.9 0.0 0.088 12.0 0.0 1.3 1 0 0 1 1 1 0 AIG1 family FeoB_N PF02421.16 NM_032380.4_3 - 0.083 12.3 0.0 0.56 9.6 0.0 2.3 2 1 0 2 2 2 0 Ferrous iron transport protein B Ribosomal_60s PF00428.17 NM_001003.2_1 - 9.7e-27 93.2 3.6 9.7e-27 93.2 3.6 1.4 2 0 0 2 2 2 1 60s Acidic ribosomal protein HK PF02110.13 NM_001003.2_1 - 0.067 12.4 0.1 0.087 12.1 0.1 1.2 1 0 0 1 1 1 0 Hydroxyethylthiazole kinase family DEC-1_N PF04625.11 NM_001003.2_1 - 0.26 10.1 1.9 0.33 9.8 1.9 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Guanylate_kin PF00625.19 NM_001932.4_2 - 1.2e-42 145.5 0.0 1.9e-42 144.9 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase L27 PF02828.14 NM_001932.4_2 - 3.9e-25 87.2 6.2 5.1e-14 51.6 1.9 2.7 2 0 0 2 2 2 2 L27 domain PDZ PF00595.22 NM_001932.4_2 - 3.9e-11 43.0 0.9 7.5e-11 42.1 0.9 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001932.4_2 - 2.8e-05 24.2 0.1 5.7e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 PDZ domain SH3_2 PF07653.15 NM_001932.4_2 - 5.8e-05 22.6 0.0 0.00013 21.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001932.4_2 - 0.0069 15.8 0.0 0.015 14.7 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001932.4_2 - 0.01 15.5 0.0 0.024 14.4 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain DUF4886 PF16227.3 NM_001932.4_2 - 0.11 11.5 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) PI-PLC-X PF00388.17 NM_000933.3_1 - 3.7e-62 208.1 1.1 6.9e-62 207.2 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 NM_000933.3_1 - 3.7e-42 143.2 0.7 3.7e-42 143.2 0.7 3.3 2 1 1 3 3 3 1 Phosphatidylinositol-specific phospholipase C, Y domain DUF1154 PF06631.9 NM_000933.3_1 - 7.1e-18 64.2 12.1 7.1e-18 64.2 12.1 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1154) EF-hand_like PF09279.9 NM_000933.3_1 - 4.9e-13 49.3 0.1 4.9e-13 49.3 0.1 2.5 3 0 0 3 3 3 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.28 NM_000933.3_1 - 3e-08 33.7 0.0 7.2e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 C2 domain EF-hand_6 PF13405.4 NM_000933.3_1 - 0.21 11.5 0.5 0.78 9.7 0.5 2.0 1 0 0 1 1 1 0 EF-hand domain Ig_3 PF13927.4 NM_020116.4_2 - 1.8e-27 95.6 0.5 1e-15 58.0 0.1 2.7 3 0 0 3 3 2 2 Immunoglobulin domain I-set PF07679.14 NM_020116.4_2 - 2.3e-25 88.4 0.1 6.1e-15 54.9 0.0 2.7 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_020116.4_2 - 1.2e-16 60.7 0.1 7.8e-08 32.4 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_020116.4_2 - 1.5e-15 57.0 0.0 5.8e-07 29.5 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain Kazal_2 PF07648.13 NM_020116.4_2 - 6.9e-08 32.4 4.9 2e-07 31.0 4.9 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain V-set PF07686.15 NM_020116.4_2 - 2.2e-05 24.4 2.1 0.17 11.9 0.1 3.6 3 1 0 3 3 3 2 Immunoglobulin V-set domain Kazal_1 PF00050.19 NM_020116.4_2 - 2.6e-05 24.0 9.2 7.3e-05 22.6 9.2 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_1 PF00036.30 NM_020116.4_2 - 0.00011 21.4 0.2 0.0003 20.0 0.2 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.4 NM_020116.4_2 - 0.00018 21.1 0.8 0.0019 17.9 0.2 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.4 NM_020116.4_2 - 0.0073 16.6 2.5 0.016 15.5 2.5 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 NM_020116.4_2 - 0.04 13.3 0.1 0.1 12.0 0.1 1.7 1 0 0 1 1 1 0 EF hand Nsp1_C PF05064.11 NM_017681.2_2 - 3.9e-34 116.8 2.8 6.2e-34 116.2 2.8 1.2 1 0 0 1 1 1 1 Nsp1-like C-terminal region RCC1 PF00415.16 NM_001268.3_1 - 1.2e-57 192.1 28.6 6.4e-15 55.4 1.6 6.1 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 NM_001268.3_1 - 2.3e-26 90.8 31.7 6.1e-12 44.9 0.9 5.7 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.29 NM_001268.3_1 - 1.6e-18 66.8 1.8 2.7e-16 59.6 0.2 2.3 1 1 1 2 2 2 2 BTB/POZ domain BACK PF07707.13 NM_001268.3_1 - 8.4e-05 22.5 2.1 0.0014 18.6 0.2 2.8 2 1 1 3 3 3 1 BTB And C-terminal Kelch M20_dimer PF07687.12 NM_001198896.1_1 - 6.2e-14 51.7 0.0 1.1e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.26 NM_001198896.1_1 - 3e-13 49.8 0.0 5.2e-08 32.7 0.0 2.3 1 1 1 2 2 2 2 Peptidase family M20/M25/M40 IL1 PF00340.17 NM_173204.1_1 - 3.6e-12 45.9 0.1 4.9e-12 45.5 0.1 1.2 1 0 0 1 1 1 1 Interleukin-1 / 18 Ig_3 PF13927.4 NM_017455.3_3 - 2.1e-20 73.0 3.0 1e-11 45.1 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_017455.3_3 - 1.3e-13 50.7 0.2 1e-09 38.2 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_017455.3_3 - 2.7e-13 49.9 0.8 2.2e-05 24.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_017455.3_3 - 8.8e-11 41.7 0.8 0.00046 20.2 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_017455.3_3 - 7.2e-05 22.8 5.5 0.26 11.3 0.0 4.0 2 2 1 3 3 3 2 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_017455.3_3 - 0.0071 16.6 0.1 0.75 10.1 0.0 2.5 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain ABC1 PF03109.14 NM_001142555.2_1 - 5.2e-32 110.4 0.0 7.8e-32 109.8 0.0 1.3 1 0 0 1 1 1 1 ABC1 family VGCC_alpha2 PF08473.9 NM_000722.3_3 - 3.3e-213 708.1 1.3 4.9e-213 707.6 1.3 1.2 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.9 NM_000722.3_3 - 1.1e-39 135.5 0.1 2.5e-39 134.4 0.1 1.6 1 0 0 1 1 1 1 VWA N-terminal VWA PF00092.26 NM_000722.3_3 - 1e-20 74.6 0.9 1.7e-20 73.9 0.9 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 NM_000722.3_3 - 7.1e-15 55.1 0.0 1.1e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.16 NM_000722.3_3 - 2.4e-11 43.8 11.8 3.4e-10 40.0 0.2 3.8 3 1 0 3 3 3 2 Cache domain VWA_2 PF13519.4 NM_000722.3_3 - 3.7e-10 40.3 1.2 1e-09 38.8 0.4 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain Cache_3-Cache_2 PF17201.2 NM_000722.3_3 - 0.0072 15.5 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain Latrophilin PF02354.14 NM_014921.4_3 - 2.8e-145 484.0 0.0 4.6e-145 483.3 0.0 1.4 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region OLF PF02191.14 NM_014921.4_3 - 1.7e-84 283.2 3.0 2.3e-84 282.7 3.0 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain 7tm_2 PF00002.22 NM_014921.4_3 - 4.6e-66 222.5 18.9 6.9e-66 221.9 18.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.3 NM_014921.4_3 - 1.6e-53 181.1 0.3 2.3e-53 180.6 0.3 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.16 NM_014921.4_3 - 9.5e-23 80.3 0.8 2.4e-22 79.0 0.8 1.7 1 0 0 1 1 1 1 Galactose binding lectin domain GPS PF01825.19 NM_014921.4_3 - 8.6e-14 51.8 5.8 2.3e-13 50.4 5.8 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 NM_014921.4_3 - 2.3e-08 34.1 0.3 5.9e-08 32.8 0.3 1.8 1 0 0 1 1 1 1 Hormone receptor domain Fis1_TPR_N PF14852.4 NM_001271520.1_1 - 0.52 9.9 1.7 1.8 8.1 0.0 2.2 2 0 0 2 2 2 0 Fis1 N-terminal tetratricopeptide repeat tRNA-synt_2 PF00152.18 NM_001293312.1_3 - 2.6e-79 266.4 0.2 3.4e-79 266.0 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.23 NM_001293312.1_3 - 6.5e-09 35.5 1.3 1.1e-08 34.8 1.3 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.18 NM_001293312.1_3 - 0.00041 19.8 0.3 0.9 8.8 0.2 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) S-AdoMet_synt_N PF00438.18 NM_001293312.1_3 - 0.071 13.7 0.3 0.16 12.5 0.3 1.5 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, N-terminal domain EGF PF00008.25 NM_013959.3_3 - 0.00079 19.5 2.9 0.0022 18.1 2.9 1.8 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.11 NM_013959.3_3 - 0.033 14.4 1.3 0.11 12.7 1.3 2.0 1 1 0 1 1 1 0 EGF-like domain THAP PF05485.10 NM_031435.3_2 - 4.3e-17 62.7 1.0 8.8e-17 61.7 1.0 1.6 1 0 0 1 1 1 1 THAP domain PPI_Ypi1 PF07491.9 NM_021959.2_2 - 8.1e-21 73.5 3.6 1.6e-20 72.6 3.6 1.4 1 0 0 1 1 1 1 Protein phosphatase inhibitor Pkinase PF00069.23 NM_001014834.2_1 - 1.4e-66 224.4 0.0 1.7e-66 224.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001014834.2_1 - 8.9e-43 146.3 0.0 1.2e-42 145.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 NM_001014834.2_1 - 4.1e-16 59.0 0.0 8.8e-16 57.9 0.0 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 NM_001014834.2_1 - 3.3e-07 29.8 0.0 4.4e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 NM_001014834.2_1 - 0.04 13.7 0.3 0.33 10.7 0.2 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.12 NM_001014834.2_1 - 0.13 11.4 0.1 0.2 10.8 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family KIND PF16474.3 NM_001014834.2_1 - 0.21 11.4 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain Axin_b-cat_bind PF08833.8 NM_001014834.2_1 - 1.7 8.6 5.6 0.21 11.6 0.3 2.3 2 0 0 2 2 2 0 Axin beta-catenin binding domain RGS PF00615.17 NM_001102445.2_3 - 1.8e-35 121.7 4.3 3e-35 120.9 4.3 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain Calcipressin PF04847.10 NM_001251974.1_1 - 8.1e-63 211.4 0.2 1.3e-62 210.8 0.2 1.2 1 0 0 1 1 1 1 Calcipressin RRM_1 PF00076.20 NM_001251974.1_1 - 0.064 13.0 0.3 0.1 12.3 0.3 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 7tm_2 PF00002.22 NM_001145147.1_2 - 3.8e-78 262.0 19.3 4.8e-78 261.7 19.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_001145147.1_2 - 0.025 14.8 0.2 0.069 13.3 0.2 1.8 1 0 0 1 1 1 0 Hormone receptor domain Glyco_trans_1_2 PF13524.4 NM_001145147.1_2 - 0.097 12.9 0.1 23 5.4 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferases group 1 MORN PF02493.18 NM_024848.2_3 - 2.2e-34 115.2 44.2 1.2e-07 31.1 1.6 8.8 9 0 0 9 9 9 8 MORN repeat PSS PF03034.13 NM_014754.2_3 - 1.2e-105 353.1 21.7 1.2e-105 353.1 21.7 1.8 2 0 0 2 2 2 1 Phosphatidyl serine synthase RNase_T PF00929.22 NM_001303236.1_2 - 3.9e-06 27.4 0.0 0.0061 17.0 0.0 2.1 2 0 0 2 2 2 2 Exonuclease RCC1_2 PF13540.4 NM_001303236.1_3 - 0.036 13.8 0.9 0.14 11.9 0.9 2.0 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat Ras PF00071.20 NM_022337.2_3 - 4.4e-42 143.3 0.0 5.7e-42 142.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_022337.2_3 - 8.3e-28 96.9 0.0 1.2e-27 96.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_022337.2_3 - 8.3e-11 41.5 0.1 7.8e-10 38.3 0.0 2.1 1 1 1 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_022337.2_3 - 5.7e-06 25.7 0.0 7.7e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.9 NM_022337.2_3 - 0.0032 16.6 0.0 0.012 14.7 0.0 1.8 1 1 1 2 2 2 1 Bacterial TniB protein MMR_HSR1 PF01926.21 NM_022337.2_3 - 0.0058 16.6 0.0 0.0081 16.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 NM_022337.2_3 - 0.036 14.2 0.0 0.07 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Kinesin PF00225.21 NM_004521.2_3 - 1e-111 372.9 1.6 1e-111 372.9 1.6 2.2 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.3 NM_004521.2_3 - 1e-28 100.0 0.2 1e-28 100.0 0.2 2.6 3 0 0 3 3 3 1 Microtubule binding Reo_sigmaC PF04582.10 NM_004521.2_3 - 0.033 13.5 28.5 0.15 11.3 7.8 3.6 2 1 1 3 3 3 0 Reovirus sigma C capsid protein MHC_I PF00129.16 NM_001531.2_3 - 1.3e-55 187.6 0.9 1.9e-55 187.1 0.9 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_001531.2_3 - 3.3e-13 49.8 0.0 6.2e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 NM_001531.2_3 - 1.6e-09 37.4 0.4 2.5e-09 36.8 0.4 1.2 1 0 0 1 1 1 1 MHC-I family domain ACT_7 PF13840.4 NM_178831.6_1 - 2.6e-17 62.2 0.1 3.9e-17 61.6 0.1 1.3 1 0 0 1 1 1 1 ACT domain PP2C PF00481.19 NM_152542.4_3 - 2.1e-55 188.1 0.1 2.9e-55 187.6 0.1 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.4 NM_152542.4_3 - 3.8e-08 33.1 0.0 8e-08 32.0 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C zf-BED PF02892.13 NM_001144936.1_2 - 1.4e-08 34.5 0.4 0.26 11.2 0.1 4.4 4 0 0 4 4 4 3 BED zinc finger DUF3505 PF12013.6 NM_001144936.1_2 - 0.0099 16.2 0.1 38 4.6 0.1 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3505) DUF678 PF05077.10 NM_001144936.1_2 - 0.026 14.5 1.6 23 5.0 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF678) Trm112p PF03966.14 NM_001144936.1_2 - 0.068 13.6 0.1 6.4 7.3 0.0 3.7 4 0 0 4 4 4 0 Trm112p-like protein CAP_N PF01213.17 NM_001144936.1_2 - 0.82 8.9 12.4 19 4.5 9.5 2.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Spt5_N PF11942.6 NM_001144936.1_2 - 1.5 9.7 11.4 8.1 7.4 0.0 3.3 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal zf-RRN7 PF11781.6 NM_001144936.1_2 - 4.3 7.0 5.8 20 4.9 0.4 3.6 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 ADK_lid PF05191.12 NM_001144936.1_2 - 4.4 7.3 6.9 3.8 7.5 0.0 3.5 4 0 0 4 4 4 0 Adenylate kinase, active site lid zf-H2C2_2 PF13465.4 NM_001286052.1_1 - 5.9e-133 427.8 142.7 4.3e-09 36.3 1.3 19.8 19 0 0 19 19 19 17 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001286052.1_1 - 2.1e-87 282.8 124.9 2.2e-06 27.7 0.4 19.1 19 0 0 19 19 18 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001286052.1_1 - 2e-43 143.1 117.8 0.0078 16.8 1.4 18.8 18 0 0 18 18 18 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001286052.1_1 - 8.5e-43 143.5 105.9 8.4e-05 22.3 0.6 19.0 18 0 0 18 18 18 16 C2H2-type zinc finger KRAB PF01352.25 NM_001286052.1_1 - 1.6e-25 88.3 0.2 3.4e-25 87.3 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_11 PF16622.3 NM_001286052.1_1 - 1.1e-24 85.7 63.1 0.0031 17.1 0.1 17.8 19 0 0 19 19 18 10 zinc-finger C2H2-type XPA_N PF01286.16 NM_001286052.1_1 - 6.4e-23 80.3 80.6 0.94 9.4 0.1 17.7 18 0 0 18 18 17 13 XPA protein N-terminal Zn-ribbon_8 PF09723.8 NM_001286052.1_1 - 2.5e-18 65.8 106.1 0.0022 17.9 2.9 13.3 5 3 13 18 18 17 13 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001286052.1_1 - 1.1e-17 63.7 76.6 0.34 11.2 0.0 17.5 18 0 0 18 18 17 7 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 NM_001286052.1_1 - 1.6e-11 43.8 85.9 0.0026 17.5 2.8 16.1 14 4 0 14 14 13 4 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 NM_001286052.1_1 - 2.9e-09 37.4 85.1 0.32 11.7 1.4 9.5 4 1 2 9 9 9 8 zinc-ribbon family FAM178 PF14816.4 NM_001286052.1_1 - 7.1e-06 25.1 9.1 7.2 5.3 0.0 7.5 1 1 7 8 8 8 1 Family of unknown function, FAM178 ADK_lid PF05191.12 NM_001286052.1_1 - 1.4e-05 24.9 61.1 0.39 10.6 0.3 11.2 3 2 9 13 13 13 6 Adenylate kinase, active site lid C1_4 PF07975.10 NM_001286052.1_1 - 0.0097 16.0 87.8 0.14 12.3 1.7 13.3 2 1 15 18 18 18 5 TFIIH C1-like domain MRP-S23 PF10484.7 NM_001286052.1_1 - 0.034 14.3 0.0 2.1e+02 2.0 0.0 5.5 3 2 2 6 6 6 0 Mitochondrial ribosomal protein S23 zf-RING_7 PF02591.13 NM_001286052.1_1 - 0.039 14.0 74.4 6.4 6.9 0.1 16.9 18 0 0 18 18 18 0 C4-type zinc ribbon domain DUF3268 PF11672.6 NM_001286052.1_1 - 0.064 13.5 62.1 1.8 8.8 1.0 9.5 2 1 7 12 12 12 0 zinc-finger-containing domain zf-AN1 PF01428.14 NM_001286052.1_1 - 0.076 13.1 94.6 12 6.1 1.5 18.5 15 2 3 18 18 18 0 AN1-like Zinc finger PknG_rubred PF16919.3 NM_001286052.1_1 - 0.11 12.4 55.3 0.33 10.9 0.5 9.2 1 1 10 11 11 11 0 Protein kinase G rubredoxin domain GAGA PF09237.9 NM_001286052.1_1 - 0.97 9.2 23.9 0.29 10.8 0.1 7.1 6 3 4 10 10 10 0 GAGA factor YhfH PF14149.4 NM_001286052.1_1 - 4.6 7.2 84.0 16 5.5 0.3 17.2 17 0 0 17 17 17 0 YhfH-like protein PDZ PF00595.22 NM_001303514.1_3 - 1e-13 51.3 0.1 2e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001303514.1_3 - 1e-06 28.8 0.1 2.1e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 NM_001303514.1_3 - 0.009 15.9 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 Tricorn protease PDZ domain LRR_4 PF12799.5 NM_001282412.1_1 - 1.3e-43 146.0 86.4 2e-08 34.2 1.7 7.1 1 1 11 12 12 12 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_001282412.1_1 - 2.2e-28 98.8 50.0 1e-10 41.2 0.9 4.1 1 1 4 5 5 5 5 Leucine-rich repeat LRR_8 PF13855.4 NM_001282412.1_1 - 9.7e-21 73.2 42.3 7.3e-07 28.7 9.1 6.0 1 1 4 6 6 6 6 Leucine rich repeat UB2H PF14814.4 NM_001282412.1_1 - 1.1 9.2 5.1 97 2.9 0.0 4.4 2 1 3 6 6 6 0 Bifunctional transglycosylase second domain DUF1773 PF08593.8 NM_001282412.1_1 - 1.2 10.0 10.2 69 4.5 0.0 5.6 5 1 0 5 5 5 0 Domain of unknown function LRR_1 PF00560.31 NM_001282412.1_1 - 7 7.4 31.2 1.7 9.3 0.7 8.9 9 1 0 9 9 9 0 Leucine Rich Repeat SSB PF00436.23 NM_001256511.1_2 - 8.6e-31 105.9 0.1 1.2e-30 105.5 0.1 1.2 1 0 0 1 1 1 1 Single-strand binding protein family FAM217 PF15344.4 NM_001190827.1_2 - 5e-64 216.4 0.5 1.2e-63 215.1 0.5 1.6 1 0 0 1 1 1 1 FAM217 family Anoctamin PF04547.10 NM_001313726.1_1 - 1.6e-158 528.0 18.2 2.3e-158 527.4 18.2 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 NM_001313726.1_1 - 3.1e-71 239.6 0.4 5.6e-71 238.7 0.4 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin PINIT PF14324.4 NM_016166.2_2 - 3.1e-38 131.3 0.4 5.4e-38 130.5 0.4 1.4 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.18 NM_016166.2_2 - 2.5e-20 71.8 5.0 5.8e-20 70.6 5.0 1.7 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 NM_016166.2_2 - 0.00092 18.9 1.5 0.0021 17.7 1.5 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit EF-hand_6 PF13405.4 NM_033119.4_3 - 0.011 15.5 0.1 0.022 14.5 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.4 NM_033119.4_3 - 0.026 14.9 0.0 0.044 14.1 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.30 NM_033119.4_3 - 0.037 13.5 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 EF hand G-alpha PF00503.18 NM_001256414.1_3 - 1.8e-117 392.3 1.6 2.4e-117 391.9 1.6 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 NM_001256414.1_3 - 5.9e-13 48.5 0.3 2.1e-12 46.7 0.1 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family Ig_3 PF13927.4 NM_001169126.1_2 - 7.7e-07 29.5 0.1 1.4e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 NM_001169126.1_2 - 1.1e-06 28.7 0.0 1.7e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 NM_001169126.1_2 - 4.4e-05 23.3 0.0 7.1e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001169126.1_2 - 0.00033 20.8 0.0 0.00074 19.7 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 NM_001169126.1_2 - 0.0073 16.3 0.1 0.074 13.1 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin domain TonB_N PF16031.3 NM_001169126.1_2 - 0.13 12.6 13.5 0.23 11.8 13.5 1.3 1 0 0 1 1 1 0 TonB N-terminal region TPR_2 PF07719.15 NM_015608.2_3 - 0.053 13.5 7.5 0.46 10.6 0.4 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.4 NM_015608.2_3 - 0.49 10.6 5.8 4.7 7.6 1.1 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 NM_015608.2_3 - 2.2 8.1 4.9 8.3 6.3 0.5 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat CytochromB561_N PF09786.7 NM_001195190.1_1 - 0.0027 16.7 0.0 0.0028 16.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome B561, N terminal zf-H2C2_2 PF13465.4 NM_033113.2_2 - 8.7e-95 307.1 109.6 6.8e-10 38.8 2.4 18.6 19 0 0 19 19 19 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_033113.2_2 - 5.9e-81 262.5 124.5 1.1e-06 28.6 0.9 17.4 17 0 0 17 17 17 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_033113.2_2 - 9.9e-44 144.1 124.5 0.0017 18.9 0.1 18.2 18 0 0 18 18 18 17 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_033113.2_2 - 4.4e-25 87.3 32.2 0.07 13.3 0.0 15.0 16 0 0 16 16 16 7 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_033113.2_2 - 2.5e-06 27.6 69.9 0.045 14.0 0.6 13.9 16 0 0 16 16 16 4 Zinc-finger of C2H2 type GAGA PF09237.9 NM_033113.2_2 - 7.1e-05 22.4 38.3 0.081 12.6 0.2 9.0 4 3 6 10 10 10 4 GAGA factor zf-Di19 PF05605.10 NM_033113.2_2 - 0.0056 16.8 2.0 0.0056 16.8 2.0 9.2 8 3 1 10 10 9 2 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.8 NM_033113.2_2 - 0.0096 15.9 72.3 0.072 13.1 1.8 11.5 8 2 4 12 12 12 6 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_033113.2_2 - 0.11 12.4 85.6 0.48 10.3 0.7 16.2 17 0 0 17 17 17 0 C2H2-type zinc finger zf-C2HC_2 PF13913.4 NM_033113.2_2 - 0.4 10.5 0.0 0.4 10.5 0.0 8.4 11 0 0 11 11 10 0 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.3 NM_033113.2_2 - 0.42 11.3 30.0 19 5.9 0.1 7.4 7 1 1 9 9 8 0 zinc-ribbon family BolA PF01722.16 NM_033113.2_2 - 1.7 8.8 17.7 10 6.4 1.1 6.2 5 2 3 8 8 8 0 BolA-like protein C1_4 PF07975.10 NM_033113.2_2 - 3.6 7.8 46.8 3.3 7.9 0.3 9.5 7 2 1 9 9 9 0 TFIIH C1-like domain TPR_2 PF07719.15 NM_001320421.1_2 - 1.5e-27 93.3 20.5 8.9e-05 22.2 0.0 10.8 11 0 0 11 11 9 7 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001320421.1_2 - 8.2e-19 66.1 14.6 0.0044 17.0 0.0 8.8 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001320421.1_2 - 4.4e-18 65.4 14.4 0.0012 19.2 0.0 7.4 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001320421.1_2 - 8e-17 60.4 28.4 0.0024 18.4 0.1 10.7 7 2 4 11 11 10 4 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001320421.1_2 - 1e-16 61.2 14.7 2.1e-05 25.0 0.0 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001320421.1_2 - 4e-16 58.8 12.9 1.2e-06 28.5 2.1 5.5 4 1 2 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.26 NM_001320421.1_2 - 4.5e-16 57.8 22.9 0.0027 17.3 0.0 10.9 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001320421.1_2 - 6.3e-16 58.3 26.4 4.9e-07 29.8 0.5 8.3 8 1 2 10 10 9 5 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001320421.1_2 - 8.5e-12 44.5 7.8 0.0018 18.4 0.0 8.2 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001320421.1_2 - 8.4e-09 34.9 12.5 0.03 13.9 0.0 7.6 6 1 2 8 8 8 3 TPR repeat TPR_10 PF13374.4 NM_001320421.1_2 - 2.9e-08 33.2 21.0 0.0072 16.0 0.1 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_15 PF13429.4 NM_001320421.1_2 - 3.6e-08 32.8 11.8 0.029 13.5 0.5 4.9 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001320421.1_2 - 1.8e-07 31.1 16.7 0.007 16.4 0.1 5.2 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001320421.1_2 - 1e-06 28.2 9.3 3.8 7.7 0.0 8.5 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_20 PF14561.4 NM_001320421.1_2 - 2.5e-05 24.4 11.2 0.45 10.7 0.1 5.0 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001320421.1_2 - 0.002 18.5 15.0 10 6.8 0.0 8.0 9 0 0 9 9 8 0 Tetratricopeptide repeat NARP1 PF12569.6 NM_001320421.1_2 - 0.0021 16.9 0.1 0.99 8.1 0.0 2.8 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 DUF3808 PF10300.7 NM_001320421.1_2 - 0.012 14.3 0.3 0.067 11.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3808) TPR_21 PF09976.7 NM_001320421.1_2 - 0.17 11.5 11.0 2.3 7.8 0.0 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat-like domain HrpB1_HrpK PF09613.8 NM_001320421.1_2 - 0.51 9.9 5.2 3 7.3 0.1 3.2 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) zf-H2C2_2 PF13465.4 NM_001099638.1_1 - 3.4e-71 232.6 80.3 1.1e-08 35.0 0.8 13.6 14 0 0 14 14 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001099638.1_1 - 7.1e-53 174.1 80.9 2.5e-07 30.6 0.6 12.4 13 0 0 13 13 12 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001099638.1_1 - 2.4e-30 102.5 70.7 0.0025 18.4 0.6 12.0 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001099638.1_1 - 3.6e-15 55.4 56.5 0.11 12.4 0.5 11.6 11 0 0 11 11 11 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001099638.1_1 - 2.7e-07 30.5 57.3 0.076 13.0 2.3 8.4 3 2 6 10 10 10 7 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001099638.1_1 - 2.8e-05 24.2 43.6 0.029 14.5 0.0 8.8 9 0 0 9 9 9 5 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001099638.1_1 - 0.00047 20.7 40.3 0.65 10.6 0.5 6.8 2 1 6 8 8 8 6 zinc-ribbon family LIM PF00412.20 NM_001099638.1_1 - 0.082 13.0 48.7 0.091 12.9 4.4 7.7 5 1 3 8 8 8 0 LIM domain DZR PF12773.5 NM_001099638.1_1 - 0.27 11.2 43.6 0.47 10.4 0.8 6.4 1 1 2 3 3 2 0 Double zinc ribbon zf-C2HE PF16278.3 NM_001099638.1_1 - 0.34 11.3 54.4 0.86 10.0 0.3 10.9 2 1 7 9 9 9 0 C2HE / C2H2 / C2HC zinc-binding finger ADK_lid PF05191.12 NM_001099638.1_1 - 0.45 10.4 31.7 5.4 7.0 3.3 6.7 5 1 1 6 6 6 0 Adenylate kinase, active site lid Zn_Tnp_IS1595 PF12760.5 NM_001099638.1_1 - 0.67 9.8 51.0 0.055 13.3 3.5 7.7 5 3 3 8 8 8 0 Transposase zinc-ribbon domain HypA PF01155.17 NM_001099638.1_1 - 1 9.2 39.6 4.7 7.1 1.1 6.5 1 1 6 7 7 7 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ThiF PF00899.19 NM_003334.3_2 - 4e-123 409.4 0.0 1.5e-73 247.1 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.7 NM_003334.3_2 - 1.7e-97 326.1 0.1 2.6e-97 325.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.8 NM_003334.3_2 - 8.1e-37 125.7 0.0 1.6e-36 124.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.3 NM_003334.3_2 - 2.1e-33 114.2 0.1 3.6e-33 113.5 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.3 NM_003334.3_2 - 8.5e-28 96.2 0.4 2.5e-27 94.7 0.4 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle C2 PF00168.28 NM_001290334.1_2 - 1.6e-34 118.2 0.0 1.8e-17 63.4 0.0 2.2 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.22 NM_001290334.1_2 - 0.029 14.3 0.0 8.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 EphA2_TM PF14575.4 NM_001290334.1_2 - 0.1 13.3 0.0 0.18 12.5 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PYRIN PF02758.14 NM_000243.2_2 - 1.8e-23 82.4 0.2 4.4e-23 81.1 0.2 1.7 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain PRY PF13765.4 NM_000243.2_2 - 3.2e-19 68.1 0.8 2.2e-18 65.5 0.0 2.9 3 0 0 3 3 3 1 SPRY-associated domain SPRY PF00622.26 NM_000243.2_2 - 9.2e-17 61.1 0.0 1.8e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 NM_000243.2_2 - 1.3e-06 28.3 3.2 1.3e-06 28.3 3.2 2.1 2 0 0 2 2 2 1 B-box zinc finger Cyclin_N PF00134.21 NM_001282854.1_2 - 6.3e-14 51.7 0.2 9.2e-14 51.2 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.9 NM_001282854.1_2 - 7.8e-11 42.5 0.9 1.6e-10 41.5 0.0 1.9 2 0 0 2 2 2 1 Cyclin AbLIM_anchor PF16182.3 NM_001323385.1_1 - 2.7e-83 280.7 16.7 7.1e-57 193.8 10.2 2.1 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 NM_001323385.1_1 - 1.2e-14 53.9 0.8 2.3e-14 53.0 0.8 1.5 1 0 0 1 1 1 1 Villin headpiece domain STAT1_TAZ2bind PF12162.6 NM_001323385.1_1 - 0.049 13.1 0.8 6.7 6.3 0.0 2.7 2 0 0 2 2 2 0 STAT1 TAZ2 binding domain HOIP-UBA PF16678.3 NM_017999.4_1 - 6.4e-52 175.5 0.1 1.3e-51 174.5 0.1 1.5 1 0 0 1 1 1 1 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase PUB PF09409.8 NM_017999.4_1 - 5.7e-14 51.7 0.0 1.3e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 PUB domain IBR PF01485.19 NM_017999.4_1 - 6.9e-08 32.5 7.2 6.9e-08 32.5 7.2 7.0 5 2 1 6 6 6 3 IBR domain, a half RING-finger domain zf-RanBP PF00641.16 NM_017999.4_1 - 3.8e-05 22.8 8.6 0.0005 19.2 0.9 6.5 8 0 0 8 8 8 3 Zn-finger in Ran binding protein and others NMD3 PF04981.11 NM_017999.4_1 - 2.6 7.3 16.1 0.015 14.7 4.0 3.2 1 1 1 2 2 2 0 NMD3 family Gelsolin PF00626.20 NM_001323599.1_3 - 5.7e-20 70.9 0.1 4.7e-05 23.1 0.0 5.6 5 0 0 5 5 5 4 Gelsolin repeat VHP PF02209.17 NM_001323599.1_3 - 4.1e-16 58.6 0.3 2.7e-15 56.0 0.3 2.4 2 0 0 2 2 2 1 Villin headpiece domain DUF4695 PF15766.3 NM_001323599.1_3 - 0.0015 18.6 13.0 0.14 12.3 0.1 4.0 2 1 1 3 3 3 2 Domain of unknown function (DUF4695) IL1 PF00340.17 NM_000576.2_1 - 1.8e-44 150.2 0.6 3.1e-44 149.4 0.6 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.14 NM_000576.2_1 - 9.3e-40 135.8 0.2 3.5e-39 133.9 0.0 1.9 2 0 0 2 2 2 1 Interleukin-1 propeptide UBA PF00627.29 NM_005053.3_1 - 1.1e-27 95.4 2.0 6.6e-14 51.3 0.2 2.4 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.9 NM_005053.3_1 - 1.1e-24 85.8 21.2 1.9e-24 85.0 21.2 1.4 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.21 NM_005053.3_1 - 5.1e-21 74.1 0.3 8.2e-21 73.4 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 NM_005053.3_1 - 9.5e-05 22.0 0.7 0.00015 21.4 0.7 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.8 NM_005053.3_1 - 0.007 16.0 0.0 0.17 11.6 0.0 2.3 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain Rad60-SLD_2 PF13881.4 NM_005053.3_1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 NM_005053.3_1 - 0.15 12.4 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain FGF PF00167.16 NM_001257212.1_1 - 4.8e-39 133.2 0.0 1.3e-38 131.8 0.0 1.7 2 0 0 2 2 2 1 Fibroblast growth factor Fascin PF06268.11 NM_001257212.1_1 - 0.072 13.2 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Fascin domain Forkhead PF00250.16 NM_012183.2_1 - 9.2e-38 128.3 0.0 1.5e-37 127.6 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain Trp_leader2 PF08056.9 NM_012183.2_2 - 2.6 8.0 5.8 6.2 6.8 5.8 1.6 1 0 0 1 1 1 0 Tryptophan operon leader peptide HlyIII PF03006.18 NM_001324118.1_2 - 3.7e-11 43.0 0.6 5.2e-11 42.6 0.6 1.1 1 0 0 1 1 1 1 Haemolysin-III related Lactamase_B_2 PF12706.5 NM_001122838.1_2 - 4.2e-37 127.5 0.0 5.7e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.4 NM_001122838.1_2 - 4.2e-10 39.6 0.0 6.6e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.25 NM_001122838.1_2 - 0.088 12.7 0.1 0.2 11.5 0.0 1.5 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily FAM104 PF15434.4 NM_138362.3_1 - 1.9e-33 115.2 3.8 2.1e-33 115.0 2.2 1.8 2 0 0 2 2 2 1 Family 104 AP-5_subunit_s1 PF15001.4 NM_001204446.1_3 - 3.9e-70 235.7 0.0 5.4e-70 235.2 0.0 1.2 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 4HBT PF03061.20 NM_001037171.1_3 - 8.1e-07 29.2 0.0 0.0097 16.1 0.0 2.3 2 0 0 2 2 2 2 Thioesterase superfamily Leu_zip PF15294.4 NM_001276379.1_3 - 1.7e-88 296.6 26.0 2.6e-88 296.0 26.0 1.1 1 0 0 1 1 1 1 Leucine zipper PDZ PF00595.22 NM_001007069.1_1 - 6.5e-20 71.1 2.9 1.8e-12 47.3 0.1 2.3 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001007069.1_1 - 7e-11 42.2 0.2 2e-06 27.9 0.0 2.3 1 1 1 2 2 2 2 PDZ domain MFS_1 PF07690.14 NM_001323978.1_1 - 2.3e-31 108.9 50.3 1.9e-24 86.1 20.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Clusterin PF01093.15 NM_001323978.1_3 - 0.067 12.1 3.6 0.092 11.6 3.6 1.1 1 0 0 1 1 1 0 Clusterin CH PF00307.29 NM_001145319.1_1 - 1.6e-87 288.8 3.3 9e-26 90.1 0.1 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.30 NM_001145319.1_1 - 2.5e-14 51.5 1.7 9.1e-07 27.9 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 NM_001145319.1_1 - 4.9e-11 42.8 0.1 1.2e-10 41.5 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 NM_001145319.1_1 - 8.6e-10 38.1 0.5 0.0001 21.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_001145319.1_1 - 1.4e-09 36.9 0.1 0.00058 19.5 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 NM_001145319.1_1 - 3e-08 32.7 8.8 5.9e-05 22.3 0.1 3.8 3 1 1 4 4 4 2 EF hand CAMSAP_CH PF11971.6 NM_001145319.1_1 - 0.00024 20.7 0.1 0.011 15.4 0.1 2.7 2 0 0 2 2 2 1 CAMSAP CH domain SPARC_Ca_bdg PF10591.7 NM_001145319.1_1 - 0.011 15.9 0.0 0.025 14.7 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region TSP_C PF05735.10 NM_003248.5_3 - 4.8e-99 330.1 2.6 6.5e-99 329.6 2.6 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 NM_003248.5_3 - 1.4e-55 184.5 124.9 4.2e-13 48.6 13.8 9.4 7 2 1 8 8 8 7 Thrombospondin type 3 repeat COMP PF11598.6 NM_003248.5_3 - 1e-21 77.0 1.5 2.1e-21 76.0 1.5 1.6 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein EGF_CA PF07645.13 NM_003248.5_3 - 2.8e-13 49.7 45.8 2.7e-08 33.8 5.5 5.1 4 0 0 4 4 4 3 Calcium-binding EGF domain cEGF PF12662.5 NM_003248.5_3 - 1.8e-07 30.8 29.1 0.00055 19.7 3.9 4.9 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF PF00008.25 NM_003248.5_3 - 0.00011 22.3 61.6 0.00015 21.8 1.3 6.0 5 1 0 5 5 5 4 EGF-like domain EGF_3 PF12947.5 NM_003248.5_3 - 0.00032 20.7 17.8 0.00093 19.2 5.4 6.8 7 1 1 8 8 8 2 EGF domain Aconitase PF00330.18 NM_001098.2_2 - 5.3e-156 520.0 0.0 6.6e-156 519.7 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.17 NM_001098.2_2 - 9.8e-48 161.7 0.0 2e-47 160.7 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain MARVEL PF01284.21 NM_001040709.1_1 - 1.2e-38 132.2 9.0 2.6e-38 131.2 9.0 1.6 1 0 0 1 1 1 1 Membrane-associating domain DUF2838 PF10998.6 NM_001040709.1_1 - 0.84 9.8 6.2 0.071 13.3 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2838) FSAP_sig_propep PF03032.13 NM_201266.1_2 - 0.91 9.5 5.0 1.8 8.5 5.0 1.5 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide CUB PF00431.18 NM_201266.1_3 - 8.4e-57 190.1 0.0 2.8e-28 98.3 0.0 2.4 2 0 0 2 2 2 2 CUB domain F5_F8_type_C PF00754.23 NM_201266.1_3 - 1.9e-56 189.5 0.7 9.2e-28 96.8 0.0 2.3 2 0 0 2 2 2 2 F5/8 type C domain DUF3481 PF11980.6 NM_201266.1_3 - 5e-40 135.0 0.6 1e-39 133.9 0.6 1.6 1 0 0 1 1 1 1 C-terminal domain of neuropilin glycoprotein MAM PF00629.21 NM_201266.1_3 - 5.1e-31 107.6 0.0 1.2e-30 106.4 0.0 1.7 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Interferon PF00143.17 NM_021002.2_1 - 6.7e-67 224.5 2.2 7.7e-67 224.3 2.2 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain zf-CCHC_3 PF13917.4 NM_001300817.2_2 - 5.2e-17 61.4 5.3 1.1e-16 60.4 5.3 1.5 1 0 0 1 1 1 1 Zinc knuckle Mem_trans PF03547.16 NM_001300817.2_2 - 0.04 12.2 0.7 0.047 11.9 0.7 1.1 1 0 0 1 1 1 0 Membrane transport protein Macoilin PF09726.7 NM_001300817.2_2 - 0.24 9.8 25.1 0.33 9.3 25.1 1.0 1 0 0 1 1 1 0 Transmembrane protein Cwf_Cwc_15 PF04889.10 NM_001300817.2_2 - 3.3 7.2 22.2 5.2 6.6 22.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.8 NM_001300817.2_2 - 5 6.2 33.9 6.5 5.8 33.9 1.1 1 0 0 1 1 1 0 BUD22 Neur_chan_LBD PF02931.21 NM_001118886.1_2 - 1.1e-52 178.5 0.0 1.5e-52 178.0 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_001118886.1_2 - 1.9e-37 129.5 4.8 8.1e-33 114.3 1.5 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Lys PF00062.18 NM_000239.2_2 - 8.5e-56 187.4 2.3 1.2e-55 186.9 2.3 1.2 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.18 NM_000239.2_2 - 0.0042 16.6 0.0 0.0068 15.9 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain TPH PF13868.4 NM_001085447.1_2 - 2e-16 59.3 124.2 2e-16 59.3 124.2 2.1 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain CysG_dimeriser PF10414.7 NM_001085447.1_2 - 0.061 12.9 2.9 0.14 11.8 1.0 2.7 2 0 0 2 2 2 0 Sirohaem synthase dimerisation region VHL_C PF17211.1 NM_001004319.2_1 - 1.8e-18 66.2 0.2 3.1e-18 65.4 0.2 1.3 1 0 0 1 1 1 1 VHL box domain VHL PF01847.14 NM_001004319.2_2 - 8.7e-30 102.4 0.1 1.8e-29 101.4 0.1 1.5 1 0 0 1 1 1 1 VHL beta domain Peptidase_C1 PF00112.21 NM_001257972.1_1 - 3e-85 285.7 1.9 4.1e-85 285.2 1.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 NM_001257972.1_1 - 1.4e-11 44.5 2.4 2.5e-11 43.7 2.4 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 NM_001257972.1_1 - 8.9e-06 24.6 4.3 0.0023 16.6 1.4 2.1 2 0 0 2 2 2 2 Peptidase C1-like family GCV_T PF01571.19 NM_017990.4_1 - 8.5e-69 231.6 0.0 1.3e-68 231.1 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.22 NM_017990.4_1 - 2.8e-55 188.2 0.0 3.8e-55 187.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T_C PF08669.9 NM_017990.4_1 - 4.7e-21 74.7 0.0 9.1e-21 73.8 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain FAO_M PF16350.3 NM_017990.4_1 - 3e-16 59.4 0.1 5.7e-16 58.5 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain FAD_binding_2 PF00890.22 NM_017990.4_1 - 9.4e-08 31.4 0.3 1.3e-07 30.9 0.3 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.12 NM_017990.4_1 - 1.7e-06 27.3 0.0 0.0009 18.4 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.17 NM_017990.4_1 - 0.0015 17.8 0.5 0.0037 16.4 0.5 1.6 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.15 NM_017990.4_1 - 0.0018 17.4 0.8 0.46 9.5 0.0 2.2 2 0 0 2 2 2 2 Thi4 family Pyr_redox_3 PF13738.4 NM_017990.4_1 - 0.0032 16.6 0.5 1.9 7.5 0.2 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.12 NM_017990.4_1 - 0.018 13.8 2.3 0.24 10.1 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase GMC_oxred_N PF00732.17 NM_017990.4_1 - 0.018 14.3 0.1 0.84 8.8 0.0 2.1 2 0 0 2 2 2 0 GMC oxidoreductase HI0933_like PF03486.12 NM_017990.4_1 - 0.033 12.8 0.2 0.077 11.5 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_8 PF13450.4 NM_017990.4_1 - 0.04 14.0 0.2 0.093 12.8 0.2 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 NM_017990.4_1 - 0.52 10.8 1.6 14 6.2 0.2 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.23 NM_001114121.2_1 - 5.4e-66 222.5 0.0 7.1e-66 222.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001114121.2_1 - 4.9e-35 120.9 0.0 6.7e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001114121.2_1 - 1.8e-06 27.4 0.0 2.6e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SARG PF15385.4 NM_023938.5_2 - 8.8e-249 827.3 44.4 1.1e-248 827.0 44.4 1.1 1 0 0 1 1 1 1 Specifically androgen-regulated gene protein IL6Ra-bind PF09240.8 NM_001243099.1_3 - 3.7e-29 100.9 0.1 7.1e-29 100.0 0.1 1.5 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Tissue_fac PF01108.15 NM_001243099.1_3 - 2.3e-05 24.0 0.9 0.017 14.8 0.0 3.3 3 0 0 3 3 3 1 Tissue factor fn3 PF00041.19 NM_001243099.1_3 - 0.081 13.2 0.1 13 6.1 0.1 2.5 2 0 0 2 2 2 0 Fibronectin type III domain Stathmin PF00836.17 NM_001283053.1_3 - 9.2e-53 177.7 13.5 9.2e-53 177.7 13.5 2.3 2 0 0 2 2 2 1 Stathmin family NADH5_C PF06455.9 NM_001283053.1_3 - 0.17 11.3 0.1 0.26 10.7 0.1 1.2 1 0 0 1 1 1 0 NADH dehydrogenase subunit 5 C-terminus Atg14 PF10186.7 NM_001283053.1_3 - 0.38 9.7 10.9 0.61 9.0 10.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RGS-like PF09128.9 NM_198977.1_2 - 1.6e-48 164.8 7.6 5.7e-37 127.1 0.2 2.8 2 1 1 3 3 3 2 Regulator of G protein signalling-like domain RhoGEF PF00621.18 NM_198977.1_2 - 9.4e-37 126.9 0.3 1.9e-36 125.9 0.3 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.3 NM_198977.1_2 - 0.0021 17.9 0.1 0.0043 16.8 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain DUF4516 PF14990.4 NM_001135570.1_2 - 3e-23 81.1 0.7 5.3e-23 80.3 0.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4516) Trypsin PF00089.24 NM_001971.5_3 - 5.5e-69 232.2 7.9 6.4e-69 232.0 7.9 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_001971.5_3 - 6.3e-08 33.5 0.4 1.4e-07 32.4 0.4 1.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_001971.5_3 - 0.025 14.8 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Staufen_C PF16482.3 NM_001037328.2_3 - 2e-53 179.1 0.1 2.9e-50 168.9 0.0 3.6 4 0 0 4 4 4 1 Staufen C-terminal domain dsrm PF00035.24 NM_001037328.2_3 - 2e-30 105.1 0.6 8.5e-12 45.5 0.1 3.8 3 0 0 3 3 3 3 Double-stranded RNA binding motif DND1_DSRM PF14709.5 NM_001037328.2_3 - 0.0011 19.0 0.2 0.046 13.8 0.0 3.1 3 0 0 3 3 3 1 double strand RNA binding domain from DEAD END PROTEIN 1 TERB2 PF15101.4 NM_152448.2_3 - 7.9e-90 300.3 0.0 1e-89 300.0 0.0 1.1 1 0 0 1 1 1 1 Telomere-associated protein TERB2 DUF2222 PF09984.7 NM_152448.2_3 - 0.04 13.7 0.1 0.067 12.9 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) HoxA13_N PF12284.6 NM_000522.4_3 - 4.8e-20 72.2 13.4 4.8e-20 72.2 13.4 3.2 1 1 2 3 3 3 2 Hox protein A13 N terminal Homeobox PF00046.27 NM_000522.4_3 - 2.3e-17 62.4 7.8 3.9e-17 61.7 7.8 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_000522.4_3 - 0.00092 18.9 1.7 0.0019 18.0 1.7 1.5 1 0 0 1 1 1 1 Homeobox KN domain Fibrinogen_C PF00147.16 NM_001314051.1_1 - 1.8e-69 233.8 5.8 2.5e-69 233.3 5.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain SHE3 PF17078.3 NM_001314051.1_1 - 0.14 11.7 15.5 0.21 11.1 14.1 1.8 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Sema PF01403.17 NM_003966.2_2 - 1.6e-131 438.9 0.0 2.2e-131 438.4 0.0 1.2 1 0 0 1 1 1 1 Sema domain TSP_1 PF00090.17 NM_003966.2_2 - 1.3e-41 140.5 96.5 5.5e-11 42.4 8.3 7.2 7 0 0 7 7 7 6 Thrombospondin type 1 domain DASH_Hsk3 PF08227.9 NM_001320973.1_2 - 2e-09 37.5 0.4 4.6e-09 36.4 0.4 1.6 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like CC2-LZ PF16516.3 NM_001320973.1_2 - 9.1 6.5 9.2 0.98 9.6 1.9 2.5 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator KASH_CCD PF14662.4 NM_001320973.1_2 - 9.8 5.8 18.8 2.6 7.7 15.7 1.6 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH 7tm_1 PF00001.19 NM_001005738.1_1 - 1.8e-36 125.6 21.3 5.7e-36 124.0 21.3 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PID PF00640.21 NM_012435.2_1 - 1.9e-47 160.7 0.0 2.5e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.22 NM_012435.2_1 - 1e-16 60.6 0.0 1.6e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 SH2 domain Nuc_sug_transp PF04142.13 NM_001271684.1_3 - 7.2e-91 304.5 10.6 1.1e-90 303.9 10.6 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter Bromodomain PF00439.23 NM_001300966.1_3 - 3e-21 75.1 0.1 6e-21 74.2 0.1 1.5 1 0 0 1 1 1 1 Bromodomain DUF4514 PF14986.4 NM_001288741.1_2 - 7.3e-38 128.2 0.4 1.1e-37 127.6 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4514) PBD PF00786.26 NM_020239.3_3 - 0.0092 16.2 0.1 0.016 15.5 0.1 1.3 1 0 0 1 1 1 1 P21-Rho-binding domain FYVE PF01363.19 NM_020972.2_3 - 5.8e-19 67.9 11.5 5.8e-19 67.9 11.5 2.6 3 0 0 3 3 3 1 FYVE zinc finger IBR PF01485.19 NM_020972.2_3 - 6.7 6.9 12.1 39 4.4 12.1 2.4 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-H2C2_2 PF13465.4 NM_001317162.1_2 - 6.8e-12 45.1 52.9 7.8e-05 22.8 3.7 8.8 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001317162.1_2 - 2.1e-11 43.5 65.9 3.2e-05 24.0 0.5 7.6 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001317162.1_2 - 8.5e-07 29.2 77.7 0.0054 17.3 0.4 9.0 10 0 0 10 10 10 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001317162.1_2 - 0.004 17.3 24.7 0.55 10.5 4.6 6.6 5 1 1 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001317162.1_2 - 0.088 13.1 25.7 0.023 14.9 4.6 5.4 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 NM_001317162.1_2 - 3 8.1 22.1 2.1 8.6 5.2 3.4 1 1 2 3 3 3 0 C2H2-type zinc ribbon ABC_membrane PF00664.21 NM_203444.3_2 - 1.5e-59 201.8 15.5 2.8e-59 200.9 15.5 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 NM_203444.3_2 - 9.7e-33 113.5 0.0 2.8e-32 112.0 0.0 1.8 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.17 NM_203444.3_2 - 9.4e-05 21.8 0.2 0.26 10.6 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 NM_203444.3_2 - 0.0009 19.5 0.0 0.0021 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 NM_203444.3_2 - 0.0012 18.7 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 NM_203444.3_2 - 0.0021 17.6 0.0 0.0054 16.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.4 NM_203444.3_2 - 0.0023 18.1 0.0 0.012 15.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain ABC_membrane_3 PF13748.4 NM_203444.3_2 - 0.0039 16.4 5.6 0.012 14.7 5.6 1.8 1 1 0 1 1 1 1 ABC transporter transmembrane region MCU PF04678.11 NM_203444.3_2 - 0.006 16.6 0.1 0.011 15.7 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial calcium uniporter DUF4191 PF13829.4 NM_203444.3_2 - 0.0076 15.5 0.1 0.0076 15.5 0.1 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4191) AAA_15 PF13175.4 NM_203444.3_2 - 0.043 13.3 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.4 NM_203444.3_2 - 0.054 13.1 0.0 0.17 11.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.15 NM_203444.3_2 - 0.097 12.3 0.7 6 6.4 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_23 PF13476.4 NM_203444.3_2 - 0.097 13.0 0.0 0.34 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.4 NM_203444.3_2 - 0.12 12.5 0.9 1.4 9.1 0.9 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Myc_N PF01056.16 NM_001293231.1_3 - 3.4e-48 165.1 1.7 3.4e-48 165.1 1.7 1.4 2 0 0 2 2 2 1 Myc amino-terminal region HLH PF00010.24 NM_001293231.1_3 - 2.3e-15 56.2 2.1 5.6e-15 54.9 2.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TFIIF_alpha PF05793.10 NM_001293231.1_3 - 0.94 7.8 6.7 1.3 7.4 6.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Filament PF00038.19 NM_181537.3_3 - 4e-100 335.3 18.7 5.2e-100 334.9 18.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 NM_181537.3_3 - 0.0053 16.7 2.5 0.0053 16.7 2.5 3.9 4 1 0 4 4 4 2 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.17 NM_181537.3_3 - 1.3 6.7 7.2 0.35 8.6 3.6 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.12 NM_181537.3_3 - 1.4 8.5 22.3 93 2.6 0.0 3.6 2 1 0 2 2 2 0 IncA protein FlxA PF14282.4 NM_181537.3_3 - 1.7 8.5 18.2 0.15 11.9 6.9 3.7 2 1 1 3 3 3 0 FlxA-like protein Reo_sigmaC PF04582.10 NM_181537.3_3 - 2.1 7.5 9.1 0.52 9.5 3.0 2.4 2 1 0 3 3 3 0 Reovirus sigma C capsid protein SlyX PF04102.10 NM_181537.3_3 - 5.3 7.6 14.6 75 3.9 0.2 4.6 3 1 1 4 4 4 0 SlyX DUF4446 PF14584.4 NM_181537.3_3 - 6.1 6.7 8.1 5.5 6.8 0.0 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) Dimer_Tnp_hAT PF05699.12 NM_004729.3_1 - 7.8e-15 54.3 0.0 2.3e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-BED PF02892.13 NM_004729.3_1 - 7.3e-14 51.4 0.9 7.3e-14 51.4 0.9 2.0 2 0 0 2 2 2 1 BED zinc finger DUF4413 PF14372.4 NM_004729.3_1 - 0.00017 21.7 0.1 0.00044 20.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) DUF1620 PF07774.11 NM_015047.2_3 - 8.5e-75 251.0 0.1 1.4e-74 250.2 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.4 NM_015047.2_3 - 1.8e-08 34.2 0.7 6.3e-06 25.8 0.8 2.6 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.19 NM_015047.2_3 - 7.9e-06 25.4 0.0 0.053 13.3 0.0 3.2 3 0 0 3 3 3 2 PQQ enzyme repeat Ion_trans PF00520.29 NM_004974.3_1 - 2.5e-50 170.9 11.3 2.5e-50 170.9 11.3 1.5 2 0 0 2 2 2 1 Ion transport protein BTB_2 PF02214.20 NM_004974.3_1 - 3.4e-28 97.7 0.0 6e-28 96.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_004974.3_1 - 2.5e-14 52.9 4.1 2.5e-14 52.9 4.1 3.0 3 1 1 4 4 4 1 Ion channel PKD_channel PF08016.10 NM_004974.3_1 - 0.031 12.8 2.7 0.019 13.5 0.6 1.6 1 1 1 2 2 2 0 Polycystin cation channel PRY PF13765.4 NM_025236.3_3 - 5.2e-17 61.1 0.0 9.5e-17 60.2 0.0 1.5 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_4 PF15227.4 NM_025236.3_3 - 3.6e-07 30.1 8.3 7.2e-07 29.1 8.3 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 NM_025236.3_3 - 2.3e-06 27.3 6.0 4.3e-06 26.4 6.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_025236.3_3 - 3.2e-06 26.9 6.1 7.5e-06 25.7 6.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_025236.3_3 - 2.9e-05 23.7 8.4 9.7e-05 22.0 8.4 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_025236.3_3 - 9.2e-05 22.5 7.6 0.00022 21.3 7.6 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_025236.3_3 - 0.00025 20.8 5.9 0.00061 19.6 5.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain SPRY PF00622.26 NM_025236.3_3 - 0.00029 20.8 0.0 0.00045 20.2 0.0 1.2 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.4 NM_025236.3_3 - 0.0032 17.1 8.0 0.0061 16.3 8.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 NM_025236.3_3 - 0.017 14.8 5.3 0.043 13.6 5.3 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 NM_025236.3_3 - 0.11 12.3 8.6 0.51 10.1 8.8 2.1 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-4CXXC_R1 PF10497.7 NM_025236.3_3 - 0.24 11.5 2.9 0.51 10.5 2.9 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Rad50_zn_hook PF04423.12 NM_025236.3_3 - 9.9 6.0 6.7 1.1 9.0 0.1 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif PNMA PF14893.4 NM_001312891.1_2 - 3.6e-42 144.8 0.0 4.8e-42 144.4 0.0 1.2 1 0 0 1 1 1 1 PNMA zf-C2H2_10 PF16588.3 NM_001312891.1_2 - 0.01 15.4 3.9 0.02 14.5 3.9 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger zf-CCHC PF00098.21 NM_001312891.1_2 - 0.13 12.3 2.8 0.3 11.1 2.8 1.7 1 0 0 1 1 1 0 Zinc knuckle DDE_Tnp_1_7 PF13843.4 NM_170753.3_2 - 2.8e-102 342.5 0.0 3.5e-102 342.2 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 C1_2 PF03107.14 NM_170753.3_2 - 0.024 14.8 4.0 0.024 14.8 4.0 2.1 2 0 0 2 2 2 0 C1 domain zf-B_box PF00643.22 NM_170753.3_2 - 0.078 13.0 8.5 0.18 11.9 8.5 1.6 1 0 0 1 1 1 0 B-box zinc finger PHD PF00628.27 NM_170753.3_2 - 1.6 8.5 7.4 4 7.3 6.9 1.9 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.20 NM_170753.3_2 - 3.2 7.6 10.9 1.6 8.5 7.9 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FMN_dh PF01070.16 NM_017545.2_1 - 6.4e-136 452.8 0.0 7.4e-136 452.6 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.23 NM_017545.2_1 - 6e-06 25.4 0.5 2.1e-05 23.5 0.2 1.9 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.15 NM_017545.2_1 - 0.00038 19.6 0.1 0.00056 19.0 0.1 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.19 NM_017545.2_1 - 0.0026 17.1 0.1 0.0076 15.6 0.1 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.12 NM_017545.2_1 - 0.0044 16.2 0.1 0.34 10.1 0.1 2.4 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG NMO PF03060.13 NM_017545.2_1 - 0.008 15.5 0.2 0.013 14.7 0.2 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase G3P_antiterm PF04309.10 NM_017545.2_1 - 0.017 14.4 0.0 4.7 6.4 0.0 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator TMP-TENI PF02581.15 NM_017545.2_1 - 0.063 12.5 0.1 0.24 10.6 0.0 1.9 2 0 0 2 2 2 0 Thiamine monophosphate synthase/TENI DHO_dh PF01180.19 NM_017545.2_1 - 0.064 12.3 0.0 0.2 10.7 0.0 1.7 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase Peptidase_C32 PF05411.10 NM_017545.2_1 - 0.12 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Equine arteritis virus putative proteinase Dus PF01207.15 NM_017545.2_1 - 0.18 10.7 0.0 14 4.5 0.0 2.2 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) LRR_9 PF14580.4 NM_001305581.1_2 - 1.5e-14 53.8 2.8 1.5e-14 53.8 2.8 2.2 2 1 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 NM_001305581.1_2 - 1.1e-08 35.0 27.5 9.7e-06 25.7 6.2 3.8 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_001305581.1_2 - 0.00023 20.7 15.4 0.0088 15.6 2.9 3.1 3 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.4 NM_001305581.1_2 - 0.16 11.9 6.4 11 6.3 0.3 3.7 3 0 0 3 3 3 0 Leucine Rich repeat EpoR_lig-bind PF09067.8 NM_001204315.1_1 - 1.8e-22 79.4 0.0 3.2e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 NM_001204315.1_1 - 4.3e-08 33.2 0.6 0.0018 18.5 0.0 3.1 3 1 0 3 3 3 2 Fibronectin type III domain IL6Ra-bind PF09240.8 NM_001204315.1_1 - 1.3e-06 28.6 0.1 2.4e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding NAC PF01849.16 NM_001113203.2_1 - 2.5e-24 84.9 0.3 8.9e-24 83.1 0.3 2.0 1 0 0 1 1 1 1 NAC domain RNA_pol_Rpo13 PF12136.6 NM_001113203.2_1 - 0.38 10.5 3.9 0.8 9.5 3.9 1.5 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain Pkinase PF00069.23 NM_001031812.3_3 - 7.7e-26 90.9 0.0 1.4e-25 90.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CK1gamma_C PF12605.6 NM_001031812.3_3 - 2.5e-16 60.5 4.5 7.1e-09 36.6 0.7 2.4 1 1 1 2 2 2 2 Casein kinase 1 gamma C terminal Pkinase_Tyr PF07714.15 NM_001031812.3_3 - 4.9e-14 52.1 0.0 1.2e-13 50.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase V-set PF07686.15 NM_018965.3_3 - 2e-09 37.4 0.1 3.2e-09 36.8 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 NM_018965.3_3 - 0.0045 17.0 1.1 0.044 13.8 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 NM_018965.3_3 - 0.03 14.8 0.0 0.065 13.7 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin domain Clat_adaptor_s PF01217.18 NM_001271734.1_3 - 2.4e-37 127.9 0.7 3.3e-37 127.4 0.7 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Cupin_8 PF13621.4 NM_005090.3_2 - 6.1e-48 163.7 0.0 9.4e-48 163.1 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain PLA2_B PF01735.16 NM_005090.3_2 - 2e-28 98.9 0.0 1.7e-27 95.9 0.0 1.9 2 0 0 2 2 2 1 Lysophospholipase catalytic domain C2 PF00168.28 NM_005090.3_2 - 1.1e-17 64.0 0.0 2.2e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain Pkinase_Tyr PF07714.15 NM_173175.2_3 - 3.6e-93 311.5 0.0 5.7e-93 310.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.11 NM_173175.2_3 - 1.9e-52 176.6 1.9 3.5e-52 175.7 1.9 1.5 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.23 NM_173175.2_3 - 1.2e-42 146.0 0.0 2.1e-42 145.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 NM_173175.2_3 - 5.1e-12 46.1 1.4 1.6e-11 44.5 1.4 1.8 1 0 0 1 1 1 1 FERM central domain Oxysterol_BP PF01237.16 NM_145798.2_3 - 3.8e-132 440.5 3.2 9.4e-132 439.2 3.2 1.6 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.4 NM_145798.2_3 - 4.6e-14 52.3 0.5 9.2e-14 51.4 0.5 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 NM_145798.2_3 - 3.7e-08 33.7 0.3 9.4e-08 32.4 0.3 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_145798.2_3 - 0.44 10.9 4.8 1.2 9.4 2.5 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain Cep57_MT_bd PF06657.11 NM_145798.2_3 - 6 7.2 6.2 22 5.4 0.1 3.3 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 MtN3_slv PF03083.14 NM_001287589.1_1 - 3.3e-19 68.6 0.1 5.4e-19 67.9 0.1 1.3 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange MtN3_slv PF03083.14 NM_001287589.1_2 - 1.2e-09 37.9 0.1 1.7e-09 37.4 0.1 1.2 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange Hydrolase PF00702.24 NM_005244.4_3 - 3.3e-06 27.4 0.0 4.6e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Phage_holin_3_6 PF07332.9 NM_005244.4_3 - 6.8 6.6 5.7 12 5.9 5.7 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III SNF2_N PF00176.21 NM_001128848.1_1 - 2.1e-73 247.0 0.8 2.1e-73 247.0 0.8 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.29 NM_001128848.1_1 - 6.1e-22 78.0 0.3 6.5e-20 71.4 0.0 3.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.11 NM_001128848.1_1 - 6.1e-21 74.4 15.6 6.1e-21 74.4 15.6 4.4 5 0 0 5 5 5 1 HSA Bromodomain PF00439.23 NM_001128848.1_1 - 1.6e-20 72.8 0.2 9.3e-20 70.4 0.3 2.3 2 0 0 2 2 2 1 Bromodomain SnAC PF14619.4 NM_001128848.1_1 - 9e-18 64.6 7.4 9e-18 64.6 7.4 6.4 7 2 1 8 8 8 1 Snf2-ATP coupling, chromatin remodelling complex BRK PF07533.14 NM_001128848.1_1 - 1.3e-17 63.0 0.0 2.6e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 BRK domain QLQ PF08880.9 NM_001128848.1_1 - 5.8e-15 54.6 4.3 1.3e-14 53.5 4.3 1.7 1 0 0 1 1 1 1 QLQ ResIII PF04851.13 NM_001128848.1_1 - 1.1e-09 38.4 0.0 1.1e-09 38.4 0.0 3.3 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DUF2009 PF09418.8 NM_001128848.1_1 - 0.29 10.0 12.6 0.29 10.0 10.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2009) IL34 PF15036.4 NM_001172771.1_1 - 4.1e-75 251.0 0.6 5.2e-75 250.6 0.6 1.1 1 0 0 1 1 1 1 Interleukin 34 Myosin_tail_1 PF01576.17 NM_001093729.1_2 - 4.3e-05 21.4 31.7 4.3e-05 21.4 31.7 3.0 2 1 1 3 3 3 2 Myosin tail DUF948 PF06103.9 NM_001093729.1_2 - 2 8.6 3.8 5.5 7.2 0.8 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.10 NM_001093729.1_2 - 5.7 6.9 9.2 22 5.0 8.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Serpin PF00079.18 NM_001271822.1_3 - 3.2e-130 434.6 2.6 3.6e-130 434.4 2.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Hyccin PF09790.7 NM_001321623.1_2 - 1.1e-116 389.2 0.1 1.7e-116 388.7 0.1 1.2 1 0 0 1 1 1 1 Hyccin ANF_receptor PF01094.26 NM_001258020.1_3 - 2.5e-64 217.5 0.1 1e-63 215.5 0.1 1.9 1 1 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 NM_001258020.1_3 - 4.2e-60 201.8 0.1 7.6e-60 200.9 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_001258020.1_3 - 3.2e-44 149.7 0.0 1e-43 148.0 0.0 1.9 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_001258020.1_3 - 1.4e-22 80.1 0.0 2.6e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 NM_001258020.1_3 - 0.11 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein DUF659 PF04937.13 NM_001258020.1_3 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) KH_1 PF00013.27 NM_005016.5_3 - 3.3e-48 161.2 15.8 1.5e-17 63.0 0.8 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 NM_005016.5_3 - 7.1e-13 48.1 7.6 0.00019 21.1 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 NM_005016.5_3 - 1.7e-05 24.5 3.8 0.33 10.7 0.3 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.4 NM_005016.5_3 - 0.0017 18.2 7.1 1.2 9.1 0.1 3.3 3 0 0 3 3 3 3 NusA-like KH domain Tom7 PF08038.10 NM_005016.5_3 - 0.11 12.1 0.2 0.26 10.9 0.2 1.7 1 0 0 1 1 1 0 TOM7 family UQ_con PF00179.24 NM_194260.2_3 - 9.3e-48 161.3 0.0 1.3e-47 160.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 NM_194260.2_3 - 0.0011 18.6 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B Pkinase PF00069.23 NM_013254.3_1 - 6.4e-45 153.4 0.0 1.4e-44 152.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_013254.3_1 - 3.5e-26 91.9 0.0 6.8e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_013254.3_1 - 0.00022 20.5 0.0 0.0027 16.9 0.0 2.3 2 0 0 2 2 2 1 Kinase-like DUF713 PF05218.12 NM_013254.3_1 - 0.00064 19.4 2.2 0.0015 18.2 2.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF713) CEP63 PF17045.3 NM_013254.3_1 - 0.0014 18.5 4.9 0.0031 17.3 4.9 1.5 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa Casc1_N PF15927.3 NM_013254.3_1 - 0.36 10.3 8.5 0.24 10.9 6.1 1.8 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus Pkinase PF00069.23 NM_001320918.1_2 - 6.9e-77 258.2 0.0 8.4e-77 257.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001320918.1_2 - 1.1e-34 119.8 0.0 1.4e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001320918.1_2 - 0.0094 15.2 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 NM_001320918.1_2 - 0.018 14.8 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 NM_001320918.1_2 - 0.14 11.4 0.0 0.39 9.9 0.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ank_2 PF12796.5 NM_001012428.2_2 - 6.4e-28 97.0 7.9 2.3e-11 44.0 2.5 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_001012428.2_2 - 8.4e-24 80.9 8.8 0.019 15.4 0.0 6.8 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.4 NM_001012428.2_2 - 2.1e-23 82.2 6.3 1.8e-08 34.6 0.2 5.0 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001012428.2_2 - 9.4e-21 73.5 15.1 1e-05 25.6 0.2 5.9 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 NM_001012428.2_2 - 9.8e-17 60.5 12.2 0.0017 18.6 0.1 7.1 6 1 1 7 7 7 5 Ankyrin repeat SOCS_box PF07525.14 NM_001012428.2_2 - 2.6e-09 37.1 6.5 7.3e-09 35.7 6.5 1.8 1 0 0 1 1 1 1 SOCS box Ofd1_CTDD PF10637.7 NM_018233.3_3 - 8.4e-41 139.9 1.5 4.2e-38 131.0 0.6 2.4 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.4 NM_018233.3_3 - 5.9e-35 119.7 0.1 3.5e-30 104.4 0.0 2.6 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.4 NM_018233.3_3 - 6.4e-16 58.9 0.0 1.2e-13 51.6 0.0 2.4 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily CNH PF00780.20 NM_003618.3_2 - 1e-68 231.8 0.3 1.5e-68 231.2 0.3 1.2 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 NM_003618.3_2 - 8.2e-64 215.4 0.0 1.2e-63 214.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_003618.3_2 - 8.2e-41 139.9 0.0 1.2e-40 139.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_003618.3_2 - 0.12 11.5 0.0 0.27 10.4 0.0 1.5 2 0 0 2 2 2 0 Kinase-like SMN PF06003.10 NM_001297715.1_2 - 1.8e-99 332.2 8.6 2.3e-99 331.8 8.6 1.1 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.22 NM_001297715.1_2 - 0.0066 16.3 0.1 0.01 15.7 0.1 1.2 1 0 0 1 1 1 1 Tudor domain PAP2 PF01569.19 NM_001270397.1_1 - 4.1e-07 29.7 0.7 1.2e-06 28.2 0.7 1.8 1 0 0 1 1 1 1 PAP2 superfamily CtnDOT_TraJ PF07863.9 NM_001198899.1_3 - 0.036 14.6 0.2 0.074 13.6 0.2 1.5 1 0 0 1 1 1 0 Homologues of TraJ from Bacteroides conjugative transposon JAKMIP_CC3 PF16034.3 NM_001198899.1_3 - 0.07 12.9 8.9 0.13 12.0 8.9 1.4 1 0 0 1 1 1 0 JAKMIP CC3 domain ATG16 PF08614.9 NM_001190266.1_1 - 8.7e-37 127.2 22.8 8.7e-37 127.2 22.8 1.6 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) WD40 PF00400.30 NM_001190266.1_1 - 1.4e-31 107.9 12.7 2.1e-06 28.2 0.0 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001190266.1_1 - 5.1e-08 33.0 0.1 0.017 15.3 0.0 4.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_001190266.1_1 - 2.4e-05 24.2 0.0 0.39 10.4 0.0 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 NM_001190266.1_1 - 0.0028 16.2 0.5 2 6.8 0.0 3.1 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Phage_GPO PF05929.9 NM_001190266.1_1 - 0.97 8.9 7.1 1.2 8.6 6.2 1.5 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Lebercilin PF15619.4 NM_001190266.1_1 - 1.2 8.7 24.6 2 7.9 24.6 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease LRR_8 PF13855.4 NM_021636.2_2 - 1.8e-73 242.1 38.3 4.5e-17 61.4 0.5 8.4 4 2 4 8 8 8 8 Leucine rich repeat LRR_5 PF13306.4 NM_021636.2_2 - 3.3e-34 117.5 0.0 1.4e-09 37.9 0.0 4.0 1 1 4 5 5 5 5 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_021636.2_2 - 9.7e-34 114.6 34.6 1.7e-05 24.9 0.1 9.4 5 3 5 11 11 11 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_021636.2_2 - 9e-17 61.0 7.4 0.0012 18.2 0.1 4.7 1 1 3 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.31 NM_021636.2_2 - 4.2e-09 35.4 28.9 3.6 8.3 0.1 11.7 13 0 0 13 13 13 4 Leucine Rich Repeat LRR_6 PF13516.4 NM_021636.2_2 - 0.015 15.2 35.2 1.3 9.1 0.0 9.4 10 0 0 10 10 10 0 Leucine Rich repeat Ank_2 PF12796.5 NM_001130015.1_1 - 2.5e-16 59.9 0.2 7.2e-15 55.2 0.2 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001130015.1_1 - 3.7e-15 55.9 1.2 2.2e-06 28.0 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001130015.1_1 - 4.1e-13 49.1 3.5 2.1e-06 27.8 0.4 3.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.28 NM_001130015.1_1 - 1.4e-10 41.0 1.0 0.0036 17.6 0.1 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.4 NM_001130015.1_1 - 3.9e-10 38.9 0.5 0.032 14.6 0.1 4.5 4 0 0 4 4 4 2 Ankyrin repeat zf-C2H2 PF00096.24 NM_003434.5_1 - 3.5e-78 253.8 105.8 4.5e-07 29.8 0.4 15.8 16 0 0 16 16 15 15 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_003434.5_1 - 2.2e-76 249.0 80.0 3.8e-06 27.0 0.4 15.8 15 1 1 16 16 16 14 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_003434.5_1 - 6.5e-46 150.9 101.4 0.0046 17.5 0.3 16.3 16 0 0 16 16 16 14 C2H2-type zinc finger KRAB PF01352.25 NM_003434.5_1 - 1.1e-24 85.6 0.1 2e-24 84.8 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_003434.5_1 - 8.9e-13 48.1 33.5 4.7 7.5 0.0 13.7 14 0 0 14 14 14 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_003434.5_1 - 2.3e-08 33.7 88.7 0.027 14.3 1.6 15.1 14 1 0 14 14 14 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_003434.5_1 - 9.4e-08 31.9 60.8 0.035 14.1 0.8 10.2 2 2 12 14 14 14 8 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_003434.5_1 - 2.8e-07 31.0 45.3 0.51 11.0 0.4 7.8 1 1 6 8 8 8 7 zinc-ribbon family ADK_lid PF05191.12 NM_003434.5_1 - 2.1e-05 24.3 50.2 0.039 13.9 0.5 10.2 5 2 6 11 11 11 3 Adenylate kinase, active site lid zf-C2H2_11 PF16622.3 NM_003434.5_1 - 0.00028 20.4 83.7 0.24 11.0 0.8 14.8 15 0 0 15 15 15 6 zinc-finger C2H2-type DUF3268 PF11672.6 NM_003434.5_1 - 0.0089 16.2 43.3 0.45 10.7 1.2 8.2 4 2 3 9 9 9 4 zinc-finger-containing domain Chordopox_RPO7 PF05864.10 NM_003434.5_1 - 0.061 13.5 28.8 27 5.0 0.6 10.2 10 1 1 11 11 11 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zf-trcl PF13451.4 NM_003434.5_1 - 0.11 12.2 53.2 4.9 7.0 0.1 13.4 14 1 1 15 15 15 0 Probable zinc-ribbon domain BHD_1 PF10403.7 NM_003434.5_1 - 0.12 12.1 0.1 1.8 8.3 0.0 3.0 5 0 0 5 5 5 0 Rad4 beta-hairpin domain 1 zf-met PF12874.5 NM_003434.5_1 - 7.9 6.9 70.6 4.3 7.7 0.1 13.6 14 0 0 14 14 14 0 Zinc-finger of C2H2 type DUF2799 PF10973.6 NM_003434.5_2 - 0.16 12.3 2.1 0.88 9.9 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2799) RnaseA PF00074.18 NM_198234.2_1 - 4.4e-43 146.5 10.7 5.4e-43 146.2 10.7 1.1 1 0 0 1 1 1 1 Pancreatic ribonuclease Mesothelin PF06060.10 NM_198234.2_1 - 0.13 10.4 0.3 0.17 10.0 0.3 1.0 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Reo_sigmaC PF04582.10 NM_001164399.1_3 - 2.9 7.1 11.0 1 8.6 0.4 4.0 2 1 3 6 6 6 0 Reovirus sigma C capsid protein FUSC PF04632.10 NM_001164399.1_3 - 7.5 4.8 18.1 0.2 10.1 1.8 3.7 1 1 4 5 5 5 0 Fusaric acid resistance protein family LRR_8 PF13855.4 NM_201348.1_2 - 2.5e-36 123.1 32.9 2.9e-13 49.2 0.2 6.1 4 1 2 6 6 6 5 Leucine rich repeat LRR_4 PF12799.5 NM_201348.1_2 - 9.7e-21 73.3 32.1 0.00011 22.4 2.4 7.6 4 3 3 7 7 7 7 Leucine Rich repeats (2 copies) LRRNT PF01462.16 NM_201348.1_2 - 1e-05 24.9 5.0 6.3e-05 22.4 5.0 2.6 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 NM_201348.1_2 - 1.2e-05 24.8 12.4 0.0027 17.1 1.5 4.3 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.31 NM_201348.1_2 - 0.011 16.0 31.9 3.6 8.3 0.2 10.8 10 1 0 10 10 10 0 Leucine Rich Repeat V-set PF07686.15 NM_182546.3_2 - 1.7e-08 34.5 0.0 3.7e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_182546.3_2 - 1.5e-07 31.8 0.0 3.1e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_182546.3_2 - 2.9e-07 30.3 0.6 1.3e-06 28.2 0.6 1.9 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_182546.3_2 - 1.8e-06 27.9 0.0 4.4e-06 26.6 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_182546.3_2 - 0.059 13.6 0.0 7.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin domain PRY PF13765.4 NM_171982.4_1 - 3.3e-13 48.9 0.1 6.4e-13 48.0 0.1 1.5 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 NM_171982.4_1 - 6.4e-10 39.1 0.0 1.1e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 NM_171982.4_1 - 3.5e-08 33.1 8.2 1e-07 31.5 8.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_171982.4_1 - 3.8e-08 32.9 8.7 3.8e-08 32.9 8.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_171982.4_1 - 1.2e-07 31.5 5.3 2.2e-07 30.6 3.3 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_171982.4_1 - 1.3e-07 31.2 9.6 5.1e-07 29.3 9.6 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_171982.4_1 - 1.1e-06 28.6 10.9 1.1e-06 28.6 10.9 2.5 2 0 0 2 2 1 1 Ring finger domain zf-B_box PF00643.22 NM_171982.4_1 - 2.6e-06 27.3 2.6 2.6e-06 27.3 2.6 3.5 5 0 0 5 5 4 1 B-box zinc finger zf-C3HC4_4 PF15227.4 NM_171982.4_1 - 2.9e-06 27.2 10.4 2.9e-06 27.2 10.4 2.3 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.4 NM_171982.4_1 - 6.1e-05 22.7 4.4 0.00019 21.1 4.4 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.4 NM_171982.4_1 - 6.6e-05 22.7 9.2 6.6e-05 22.7 9.2 2.4 3 0 0 3 3 1 1 zinc-RING finger domain zf-RING_10 PF16685.3 NM_171982.4_1 - 0.002 18.1 6.2 0.006 16.6 6.2 1.8 1 0 0 1 1 1 1 zinc RING finger of MSL2 Baculo_IE-1 PF05290.9 NM_171982.4_1 - 0.0046 16.8 3.9 0.0091 15.8 3.9 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.4 NM_171982.4_1 - 0.29 10.9 15.4 0.012 15.4 8.6 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 7tm_1 PF00001.19 NM_001057.2_2 - 2.2e-56 190.9 21.6 2.8e-56 190.6 21.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001057.2_2 - 2.5e-10 40.1 20.0 3.2e-10 39.7 20.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_001057.2_2 - 0.021 14.5 18.6 0.093 12.3 18.6 1.9 1 1 0 1 1 1 0 Olfactory receptor NDK PF00334.17 NM_001286433.1_2 - 7.9e-35 119.7 0.2 1.9e-21 76.3 0.1 2.1 1 1 1 2 2 2 2 Nucleoside diphosphate kinase fn3 PF00041.19 NM_019856.1_2 - 7.4e-80 263.3 0.0 3e-16 59.4 0.0 6.0 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.14 NM_019856.1_2 - 2.3e-76 251.8 8.4 1e-21 76.7 0.0 7.6 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_019856.1_2 - 5.8e-48 161.3 4.0 1.4e-10 41.5 0.1 7.8 7 0 0 7 7 7 6 Immunoglobulin domain Ig_2 PF13895.4 NM_019856.1_2 - 1e-36 125.0 6.4 1.8e-09 37.7 0.0 8.0 8 0 0 8 8 8 4 Immunoglobulin domain ig PF00047.23 NM_019856.1_2 - 2.1e-22 79.0 14.7 4.6e-05 23.4 0.0 8.3 9 0 0 9 9 9 6 Immunoglobulin domain V-set PF07686.15 NM_019856.1_2 - 1.9e-18 66.4 20.0 0.0025 17.8 0.0 10.5 7 4 1 8 8 8 6 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_019856.1_2 - 1e-09 38.2 6.1 0.054 13.4 0.0 5.2 5 0 0 5 5 5 4 CD80-like C2-set immunoglobulin domain Tissue_fac PF01108.15 NM_019856.1_2 - 3.4e-08 33.1 0.0 0.46 10.2 0.0 4.3 3 1 0 3 3 3 3 Tissue factor C1-set PF07654.13 NM_019856.1_2 - 1.2e-05 25.5 5.6 1.6 9.2 0.0 5.9 6 0 0 6 6 6 2 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 NM_019856.1_2 - 0.002 18.0 0.3 17 5.4 0.0 5.4 6 0 0 6 6 6 0 Izumo-like Immunoglobulin domain EF-hand_11 PF08976.9 NM_198856.2_2 - 2.6e-80 265.9 18.3 2.1e-60 201.9 0.3 10.2 11 0 0 11 11 11 5 EF-hand domain EF-hand_7 PF13499.4 NM_198856.2_2 - 4.9e-41 138.9 34.7 4.7e-06 26.9 0.1 12.0 10 3 1 11 11 11 9 EF-hand domain pair EF-hand_6 PF13405.4 NM_198856.2_2 - 5.7e-31 103.7 19.5 0.01 15.6 0.0 14.7 15 0 0 15 15 15 7 EF-hand domain EF-hand_1 PF00036.30 NM_198856.2_2 - 2.2e-23 79.8 17.0 0.0026 17.1 0.0 15.8 18 0 0 18 18 18 5 EF hand EF-hand_8 PF13833.4 NM_198856.2_2 - 2.7e-19 68.5 6.9 0.0045 16.6 0.0 9.2 10 0 0 10 10 10 4 EF-hand domain pair EF-hand_5 PF13202.4 NM_198856.2_2 - 2.1e-08 33.1 3.4 0.39 10.2 0.0 7.7 9 0 0 9 9 9 2 EF hand GPHH PF16905.3 NM_198856.2_2 - 0.00018 21.1 0.0 0.2 11.3 0.0 4.5 4 0 0 4 4 4 1 Voltage-dependent L-type calcium channel, IQ-associated Caleosin PF05042.11 NM_198856.2_2 - 0.13 12.0 0.6 4.2 7.1 0.0 3.6 4 0 0 4 4 4 0 Caleosin related protein BTB PF00651.29 NM_001323256.1_2 - 4.2e-27 94.4 1.3 1e-26 93.2 0.2 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.13 NM_001323256.1_2 - 6.4e-07 29.3 0.1 1.5e-06 28.1 0.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_1 PF01344.23 NM_001323256.1_3 - 1.1e-18 66.4 3.6 1.2e-08 34.2 0.0 3.7 3 1 0 3 3 3 2 Kelch motif Kelch_6 PF13964.4 NM_001323256.1_3 - 1e-15 57.2 0.8 4.7e-06 26.6 0.0 4.9 2 1 1 3 3 3 2 Kelch motif Kelch_3 PF13415.4 NM_001323256.1_3 - 5.7e-09 35.9 0.0 0.083 13.1 0.0 4.3 3 1 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.4 NM_001323256.1_3 - 6.5e-07 29.1 0.0 0.16 11.9 0.0 3.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_001323256.1_3 - 0.00024 20.9 0.0 0.03 14.2 0.1 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.13 NM_001323256.1_3 - 0.0006 19.6 0.0 0.12 12.2 0.0 2.9 2 0 0 2 2 2 1 Kelch motif BACK PF07707.13 NM_001323256.1_3 - 0.0047 16.9 0.2 0.012 15.5 0.1 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch CARD PF00619.19 NM_001276307.1_2 - 4.8e-18 64.8 0.0 6.4e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 Caspase recruitment domain Trypan_PARP PF05887.9 NM_001276307.1_2 - 0.00049 20.0 39.8 0.00091 19.2 39.8 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) A2M_comp PF07678.12 NM_001282424.2_1 - 3e-86 288.8 1.0 4.2e-86 288.3 1.0 1.2 1 0 0 1 1 1 1 A-macroglobulin complement component A2M PF00207.20 NM_001282424.2_1 - 5.8e-29 99.6 0.0 1.5e-28 98.3 0.0 1.8 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.12 NM_001282424.2_1 - 3.1e-24 85.4 0.8 8.9e-24 84.0 0.5 2.0 2 0 0 2 2 2 1 A-macroglobulin receptor A2M_N_2 PF07703.12 NM_001282424.2_1 - 8.9e-24 84.3 0.0 1.4e-22 80.4 0.0 2.4 2 0 0 2 2 2 1 Alpha-2-macroglobulin family N-terminal region Thiol-ester_cl PF10569.7 NM_001282424.2_1 - 3.6e-16 58.4 1.3 3.6e-16 58.4 1.3 2.2 2 0 0 2 2 2 1 Alpha-macro-globulin thiol-ester bond-forming region SVA PF05326.9 NM_001282424.2_1 - 5e-08 32.8 0.0 1.2e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) RRM_1 PF00076.20 NM_001013631.2_3 - 3.9e-12 45.7 0.1 7.4e-12 44.8 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XhlA PF10779.7 NM_001013631.2_3 - 0.025 14.6 6.4 0.05 13.7 6.4 1.5 1 0 0 1 1 1 0 Haemolysin XhlA APG6 PF04111.10 NM_001013631.2_3 - 0.12 11.7 9.0 0.16 11.2 9.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Nup88 PF10168.7 NM_001013631.2_3 - 0.2 9.3 6.4 0.27 8.8 6.4 1.1 1 0 0 1 1 1 0 Nuclear pore component IncA PF04156.12 NM_001013631.2_3 - 0.26 10.9 6.5 0.36 10.5 6.5 1.2 1 0 0 1 1 1 0 IncA protein PA26 PF04636.11 NM_001013631.2_3 - 0.55 9.0 4.4 7.5 5.2 5.1 1.9 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) DUF16 PF01519.14 NM_001013631.2_3 - 0.62 10.4 9.4 1.2 9.5 9.4 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 SKA1 PF07160.10 NM_001013631.2_3 - 0.81 9.4 8.9 1.3 8.7 8.9 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 RP-C_C PF11800.6 NM_001013631.2_3 - 1.2 9.0 7.7 2 8.3 7.7 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region TMPIT PF07851.11 NM_001013631.2_3 - 1.3 8.0 6.7 2.1 7.4 6.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.4 NM_001013631.2_3 - 2.8 7.1 4.9 4.3 6.5 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF972 PF06156.11 NM_001013631.2_3 - 3 8.4 7.1 6.4 7.3 7.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) TMEM214 PF10151.7 NM_001013631.2_3 - 4.1 5.6 10.9 5.6 5.2 10.9 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator PIEZO PF15917.3 NM_001013631.2_3 - 7.4 5.8 10.8 12 5.2 10.8 1.3 1 0 0 1 1 1 0 Piezo Arfaptin PF06456.11 NM_001039583.1_2 - 9.9e-85 283.6 2.1 1.5e-84 283.0 2.1 1.3 1 0 0 1 1 1 1 Arfaptin-like domain PDZ PF00595.22 NM_001039583.1_2 - 2.1e-10 40.7 0.2 3.7e-10 39.9 0.2 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001039583.1_2 - 1.1e-05 25.5 0.1 4.2e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 PDZ domain BAR PF03114.16 NM_001039583.1_2 - 1.4e-05 24.7 1.6 0.0001 21.9 1.6 2.0 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.3 NM_001039583.1_2 - 0.00087 18.9 1.6 0.53 9.8 0.4 2.2 2 0 0 2 2 2 2 BAR domain of APPL family DALR_1 PF05746.13 NM_001039583.1_2 - 0.031 14.3 0.1 0.32 11.1 0.1 2.2 2 0 0 2 2 2 0 DALR anticodon binding domain Metallophos PF00149.26 NM_001611.4_3 - 2.8e-22 80.1 0.1 3.7e-22 79.7 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 NM_001611.4_3 - 2e-05 24.8 0.0 0.0033 17.5 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.8 NM_001611.4_3 - 0.045 12.6 0.0 1 8.2 0.0 2.0 2 0 0 2 2 2 0 PhoD-like phosphatase Pyridoxal_deC PF00282.17 NM_001082971.1_1 - 4.6e-173 575.0 0.0 5.7e-173 574.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.19 NM_001082971.1_1 - 8.1e-07 28.5 0.0 1.7e-06 27.4 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.19 NM_001082971.1_1 - 0.0037 16.4 0.0 0.0058 15.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II S1-like PF14444.4 NM_001031705.2_3 - 1.9e-19 69.3 6.2 2.3e-07 30.6 1.7 3.2 3 0 0 3 3 3 3 S1-like Guanylate_cyc PF00211.18 NM_001130683.3_3 - 2.2e-62 209.8 0.0 3.2e-62 209.3 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.12 NM_001130683.3_3 - 1.3e-44 152.1 0.7 2.7e-44 151.0 0.7 1.5 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.13 NM_001130683.3_3 - 4.3e-06 26.6 0.0 7.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Haem-NO-binding TM2 PF05154.14 NM_031940.3_2 - 3.3e-14 52.8 12.2 6.6e-14 51.8 12.2 1.5 1 0 0 1 1 1 1 TM2 domain Acetyltransf_1 PF00583.23 NM_001083600.2_3 - 1.5e-13 50.9 0.0 2.4e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 NM_001083600.2_3 - 1e-07 32.1 0.0 1.7e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 NM_001083600.2_3 - 2.8e-07 30.4 0.1 2e-06 27.6 0.1 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 NM_001083600.2_3 - 8e-06 25.6 0.0 1.5e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Lectin_C PF00059.19 NM_001197317.2_1 - 3.9e-11 43.5 1.0 8.7e-11 42.4 1.0 1.6 1 0 0 1 1 1 1 Lectin C-type domain Nucleoplasmin PF03066.13 NM_001197317.2_2 - 2.3e-31 108.1 0.0 4.1e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain NPM1-C PF16276.3 NM_001197317.2_2 - 1.9e-29 101.2 1.9 1.9e-29 101.2 1.9 1.9 2 0 0 2 2 2 1 Nucleophosmin C-terminal domain SLAIN PF15301.4 NM_001197317.2_2 - 0.12 11.4 4.3 0.19 10.8 4.3 1.1 1 0 0 1 1 1 0 SLAIN motif-containing family TFIIF_alpha PF05793.10 NM_001197317.2_2 - 0.13 10.7 19.5 0.19 10.2 19.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NOA36 PF06524.10 NM_001197317.2_2 - 1.5 8.0 7.9 2.4 7.3 7.9 1.2 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.4 NM_001197317.2_2 - 6.2 7.2 9.9 15 6.0 9.9 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Spt5_N PF11942.6 NM_001197317.2_2 - 8.2 7.4 16.1 0.15 12.9 8.2 2.0 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Vitelline_membr PF10542.7 NM_001197317.2_3 - 0.042 13.6 0.1 0.17 11.7 0.1 2.0 1 0 0 1 1 1 0 Vitelline membrane cysteine-rich region 2OG-FeII_Oxy_3 PF13640.4 NM_177939.2_2 - 6.1e-14 52.5 0.1 1.2e-13 51.6 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_7 PF13499.4 NM_177939.2_2 - 2e-07 31.2 0.2 6.9e-07 29.5 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_177939.2_2 - 2e-06 26.8 0.0 0.029 13.8 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.4 NM_177939.2_2 - 1.6e-05 24.1 0.2 0.22 11.0 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_177939.2_2 - 8e-05 22.2 0.4 0.061 13.2 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.4 NM_177939.2_2 - 0.00029 20.4 0.0 1.3 8.7 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair SP_C-Propep PF08999.8 NM_199170.2_1 - 0.1 12.3 0.9 0.26 11.0 0.9 1.6 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Beach PF02138.16 NM_001144772.1_2 - 1.1e-115 385.6 0.0 1.6e-115 385.2 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain GRAM PF02893.18 NM_001144772.1_2 - 4.5e-21 74.7 0.0 7.7e-20 70.7 0.0 2.5 2 0 0 2 2 2 1 GRAM domain WD40 PF00400.30 NM_001144772.1_2 - 1.5e-14 54.0 26.1 0.017 15.8 1.9 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001144772.1_2 - 7.8e-07 29.2 1.4 0.0048 17.0 0.1 4.1 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PH_BEACH PF14844.4 NM_001144772.1_2 - 6.6e-06 26.0 0.0 0.36 10.8 0.0 3.8 2 1 0 2 2 2 2 PH domain associated with Beige/BEACH NABP PF07990.10 NM_001144772.1_2 - 0.02 14.3 0.6 0.03 13.7 0.6 1.2 1 0 0 1 1 1 0 Nucleic acid binding protein NABP ATLF PF07737.9 NM_001144772.1_2 - 0.044 12.9 0.1 0.11 11.6 0.1 1.6 1 0 0 1 1 1 0 Anthrax toxin lethal factor, N- and C-terminal domain Cytochrom_D1 PF02239.14 NM_001144772.1_2 - 0.048 12.0 0.0 0.081 11.3 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain WD40_like PF17005.3 NM_001144772.1_2 - 0.13 11.4 0.1 4.7 6.3 0.0 2.3 2 0 0 2 2 2 0 WD40-like domain VGLL4 PF15245.4 NM_001284391.1_3 - 1.8e-86 289.6 2.4 3e-86 288.8 2.4 1.3 1 0 0 1 1 1 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.12 NM_001284391.1_3 - 0.0007 19.1 0.0 1.1 8.9 0.0 2.5 2 0 0 2 2 2 2 Vestigial/Tondu family Lectin_C PF00059.19 NM_001173534.1_3 - 9e-20 71.3 0.7 1.4e-19 70.6 0.7 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 NM_001173534.1_3 - 0.0022 17.5 0.0 0.0046 16.5 0.0 1.4 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like An_peroxidase PF03098.13 NM_175940.2_2 - 4.6e-137 457.6 0.0 6.1e-137 457.2 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase NAD_binding_6 PF08030.10 NM_175940.2_2 - 3.3e-30 105.1 0.0 5.7e-30 104.4 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.17 NM_175940.2_2 - 2.8e-18 66.1 14.3 2.8e-18 66.1 14.3 2.9 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.10 NM_175940.2_2 - 4.9e-18 65.1 0.0 1.1e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain EF-hand_1 PF00036.30 NM_175940.2_2 - 2.7e-14 51.4 5.2 1.9e-06 26.8 0.7 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 NM_175940.2_2 - 2.8e-13 49.3 8.1 6.7e-05 22.4 0.1 3.5 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.4 NM_175940.2_2 - 4.4e-12 46.2 5.7 1.7e-06 28.3 1.7 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_175940.2_2 - 1.1e-11 43.5 3.1 2.1e-05 24.0 0.2 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 NM_175940.2_2 - 3e-07 29.5 2.8 0.0073 15.7 0.3 2.7 2 0 0 2 2 2 2 EF hand NAD_binding_1 PF00175.19 NM_175940.2_2 - 0.0018 18.7 0.0 0.044 14.3 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain PAP2 PF01569.19 NM_021176.2_3 - 9e-13 48.1 6.6 2.4e-12 46.7 6.6 1.6 1 0 0 1 1 1 1 PAP2 superfamily TPR_2 PF07719.15 NM_001010854.1_3 - 1.2e-27 93.6 20.5 8.8e-05 22.2 0.0 10.8 11 0 0 11 11 9 7 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001010854.1_3 - 7e-19 66.3 14.6 0.0043 17.0 0.0 8.9 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001010854.1_3 - 3.9e-18 65.6 14.4 0.0012 19.2 0.0 7.4 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001010854.1_3 - 5.6e-17 60.9 28.4 0.0024 18.4 0.1 10.9 7 2 4 11 11 10 5 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001010854.1_3 - 9.5e-17 61.3 16.3 2e-05 25.0 0.0 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001010854.1_3 - 3.3e-16 59.1 13.4 1.1e-06 28.5 2.1 5.5 4 1 2 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.26 NM_001010854.1_3 - 3.8e-16 58.0 22.9 0.0026 17.4 0.0 10.9 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001010854.1_3 - 5.3e-16 58.5 26.4 4.8e-07 29.8 0.5 8.3 8 1 2 10 10 9 5 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001010854.1_3 - 7.3e-12 44.7 7.8 0.0017 18.4 0.0 8.3 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001010854.1_3 - 7.9e-09 34.9 12.5 0.03 13.9 0.0 7.6 6 1 2 8 8 8 3 TPR repeat TPR_15 PF13429.4 NM_001010854.1_3 - 1.7e-08 33.9 11.5 0.028 13.5 0.5 5.3 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001010854.1_3 - 2.9e-08 33.2 21.0 0.0071 16.1 0.1 7.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001010854.1_3 - 1.5e-07 31.3 16.7 0.0069 16.4 0.1 5.3 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001010854.1_3 - 9e-07 28.4 9.3 3.7 7.7 0.0 8.5 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_20 PF14561.4 NM_001010854.1_3 - 3e-05 24.1 11.8 0.44 10.8 0.1 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001010854.1_3 - 0.0014 19.0 15.0 10 6.9 0.0 8.2 9 0 0 9 9 8 0 Tetratricopeptide repeat DUF3808 PF10300.7 NM_001010854.1_3 - 0.011 14.4 0.3 0.066 11.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3808) NARP1 PF12569.6 NM_001010854.1_3 - 0.049 12.4 0.4 0.59 8.8 0.0 2.6 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 TPR_21 PF09976.7 NM_001010854.1_3 - 0.067 12.8 12.9 2.1 8.0 0.1 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat-like domain HrpB1_HrpK PF09613.8 NM_001010854.1_3 - 0.46 10.0 5.2 3 7.4 0.1 3.3 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) Reprolysin PF01421.17 NM_207191.2_2 - 5.2e-55 186.3 0.0 9.5e-55 185.5 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_207191.2_2 - 9.6e-28 96.8 1.6 9.6e-28 96.8 1.6 2.9 3 0 0 3 3 2 1 ADAM cysteine-rich Disintegrin PF00200.21 NM_207191.2_2 - 3.2e-21 75.8 24.3 3.2e-21 75.8 24.3 4.2 4 1 0 4 4 2 1 Disintegrin Pep_M12B_propep PF01562.17 NM_207191.2_2 - 1.3e-14 54.5 0.0 2.8e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_207191.2_2 - 3.5e-14 53.3 0.0 7e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 NM_207191.2_2 - 6.5e-10 39.5 0.0 1.1e-09 38.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_207191.2_2 - 3.5e-07 30.2 0.0 6.1e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_207191.2_2 - 2.1e-05 24.1 0.0 3.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like CD20 PF04103.13 NM_207191.2_2 - 0.004 17.1 0.2 0.0075 16.2 0.2 1.4 1 0 0 1 1 1 1 CD20-like family Peptidase_M10 PF00413.22 NM_207191.2_2 - 0.045 13.5 0.1 0.069 12.9 0.1 1.2 1 0 0 1 1 1 0 Matrixin Peptidase_M43 PF05572.11 NM_207191.2_2 - 0.18 11.6 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A DUF4953 PF16313.3 NM_207191.2_2 - 0.2 10.7 0.1 0.33 10.0 0.1 1.2 1 0 0 1 1 1 0 Met-zincin DUF4545 PF15078.4 NM_001276352.1_1 - 1.1e-97 327.8 7.7 1.3e-97 327.6 7.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4545) DUF4545 PF15078.4 NM_001276352.1_2 - 9.2e-98 328.1 11.0 1.3e-97 327.6 11.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4545) PIP49_C PF12260.6 NM_001252270.1_1 - 3.2e-66 222.4 0.2 5.1e-66 221.8 0.2 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 PIP49_N PF14875.4 NM_001252270.1_1 - 9.4e-35 119.6 0.5 9.4e-35 119.6 0.5 1.9 2 0 0 2 2 2 1 N-term cysteine-rich ER, FAM69 zf-H2C2_2 PF13465.4 NM_014415.3_3 - 3.1e-40 134.7 90.1 1e-07 31.9 0.2 14.2 15 0 0 15 15 15 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_014415.3_3 - 1.6e-33 113.1 97.5 0.0016 18.7 0.6 13.1 13 0 0 13 13 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_014415.3_3 - 8.3e-32 107.0 92.7 0.0052 17.4 0.9 13.5 13 0 0 13 13 13 12 C2H2-type zinc finger BTB PF00651.29 NM_014415.3_3 - 1.2e-20 73.7 1.2 2.4e-20 72.7 1.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_6 PF13912.4 NM_014415.3_3 - 9.7e-12 44.4 80.4 0.00071 19.3 0.9 11.8 12 1 0 12 12 12 8 C2H2-type zinc finger zf-Di19 PF05605.10 NM_014415.3_3 - 9.1e-06 25.7 44.4 0.0014 18.7 0.7 7.2 4 2 3 7 7 7 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.5 NM_014415.3_3 - 0.00022 21.4 56.5 1.3 9.2 0.6 9.7 2 1 7 10 10 10 5 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.6 NM_014415.3_3 - 0.00087 19.4 57.5 0.47 10.7 0.2 11.8 12 0 0 12 12 12 4 Zinc-finger double-stranded RNA-binding HNH_5 PF14279.4 NM_014415.3_3 - 0.0086 15.8 1.1 0.0086 15.8 1.1 5.1 6 2 1 7 7 7 1 HNH endonuclease Ta0938 PF11494.6 NM_014415.3_3 - 0.022 14.9 9.1 3.3 7.9 0.1 4.0 4 0 0 4 4 3 0 Ta0938 zf-met PF12874.5 NM_014415.3_3 - 0.056 13.7 0.2 0.056 13.7 0.2 10.2 11 0 0 11 11 10 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_014415.3_3 - 0.079 12.6 0.0 0.079 12.6 0.0 10.0 12 0 0 12 12 11 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.3 NM_014415.3_3 - 3.3 7.5 16.1 7.8 6.3 0.1 6.1 6 1 1 7 7 7 0 C2H2 type zinc-finger (1 copy) PRAS PF15798.3 NM_032375.5_1 - 1e-48 164.8 0.8 2.1e-48 163.9 0.8 1.5 1 0 0 1 1 1 1 Proline-rich AKT1 substrate 1 RWD PF05773.20 NM_016940.2_1 - 5.5e-17 62.0 0.0 8.7e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 RWD domain DUF1115 PF06544.10 NM_016940.2_1 - 3.1e-15 56.4 0.0 6e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) SH3_1 PF00018.26 NM_207181.2_2 - 1.3e-13 50.1 0.1 2.9e-13 49.0 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_207181.2_2 - 4.1e-11 42.3 0.0 8.1e-11 41.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_207181.2_2 - 8.5e-10 38.2 0.0 2.3e-09 36.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.4 NM_207181.2_2 - 0.074 13.5 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Helically-extended SH3 domain Speriolin_N PF15058.4 NM_207181.2_2 - 0.14 12.1 2.4 0.27 11.2 2.4 1.4 1 0 0 1 1 1 0 Speriolin N terminus FAM176 PF14851.4 NM_207181.2_2 - 2.8 7.5 9.9 0.75 9.3 3.6 2.5 2 0 0 2 2 2 0 FAM176 family S_100 PF01023.17 NM_005621.1_3 - 5.4e-19 67.5 0.5 8.7e-19 66.8 0.5 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 NM_005621.1_3 - 9e-06 24.8 0.7 7.2e-05 21.9 0.3 2.1 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.4 NM_005621.1_3 - 0.00016 21.9 0.1 0.00022 21.5 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 NM_005621.1_3 - 0.00027 20.5 0.2 0.00045 19.8 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_005621.1_3 - 0.00058 19.5 0.4 0.046 13.5 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.7 NM_005621.1_3 - 0.059 13.6 0.1 0.082 13.1 0.1 1.2 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.4 NM_005621.1_3 - 0.35 10.4 1.9 1.4 8.4 1.0 2.1 2 0 0 2 2 2 0 EF hand dCache_1 PF02743.16 NM_001293274.1_1 - 3.3e-14 53.2 0.5 2.6e-08 33.9 0.0 2.2 2 0 0 2 2 2 2 Cache domain VWA_N PF08399.9 NM_001293274.1_2 - 1e-20 74.3 0.0 7.9e-19 68.2 0.0 2.2 1 1 0 1 1 1 1 VWA N-terminal WD40 PF00400.30 NM_002717.3_3 - 1.5e-06 28.7 4.7 10 7.1 0.1 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_002717.3_3 - 0.00046 20.3 0.1 1.1 9.5 0.0 3.5 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain HECT PF00632.23 NM_001144965.1_1 - 3.8e-101 338.5 0.1 5.1e-101 338.1 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 NM_001144965.1_1 - 6.7e-51 169.8 22.8 1.3e-12 47.3 0.1 4.8 4 0 0 4 4 4 4 WW domain C2 PF00168.28 NM_001144965.1_1 - 2.8e-25 88.4 0.0 6.3e-25 87.3 0.0 1.6 1 0 0 1 1 1 1 C2 domain AGTRAP PF06396.9 NM_001040196.1_3 - 4.3e-56 188.7 0.0 6.3e-56 188.1 0.0 1.2 1 0 0 1 1 1 1 Angiotensin II, type I receptor-associated protein (AGTRAP) eIF-5a PF01287.18 NM_001970.4_1 - 4.9e-25 87.3 0.2 7e-25 86.8 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.10 NM_001970.4_1 - 0.023 14.6 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain SRF-TF PF00319.16 NM_001193349.1_2 - 1.5e-23 81.8 0.4 3.7e-23 80.6 0.4 1.7 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 NM_001193349.1_2 - 0.069 13.0 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 Holliday junction regulator protein family C-terminal repeat TPR_14 PF13428.4 NM_017922.3_3 - 8.2e-10 38.5 0.1 1 10.2 0.1 6.4 6 1 1 7 7 7 2 Tetratricopeptide repeat Suf PF05843.12 NM_017922.3_3 - 2.2e-05 24.5 5.0 0.0043 16.9 0.0 3.9 3 2 1 4 4 4 2 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.10 NM_017922.3_3 - 0.0012 18.7 3.3 1.1 9.1 0.4 4.4 3 2 0 3 3 3 1 Mad3/BUB1 homology region 1 TPR_16 PF13432.4 NM_017922.3_3 - 0.039 14.5 0.1 0.23 12.0 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_017922.3_3 - 0.085 12.9 0.8 14 5.9 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 NM_017922.3_3 - 0.17 12.0 1.7 5.1 7.3 1.0 3.0 1 1 0 2 2 2 0 Tetratricopeptide repeat Mab-21 PF03281.12 NM_152367.2_2 - 1.3e-82 277.3 3.9 1.7e-82 276.9 3.9 1.1 1 0 0 1 1 1 1 Mab-21 protein DUF4407 PF14362.4 NM_152367.2_3 - 1.3 8.2 3.8 1.9 7.6 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SEA PF01390.18 NM_001204288.1_1 - 2.2e-09 37.4 0.3 3.4e-09 36.8 0.3 1.2 1 0 0 1 1 1 1 SEA domain PsbH PF00737.18 NM_001204288.1_2 - 0.087 12.4 0.3 0.15 11.7 0.3 1.3 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein IncA PF04156.12 NM_001204288.1_2 - 0.13 12.0 1.5 0.23 11.1 1.5 1.4 1 0 0 1 1 1 0 IncA protein Sec2p PF06428.9 NM_175623.3_2 - 5.4e-08 32.5 8.9 5.9e-08 32.4 7.7 1.7 1 1 0 1 1 1 1 GDP/GTP exchange factor Sec2p APG6 PF04111.10 NM_175623.3_2 - 0.1 11.9 5.1 0.16 11.2 5.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF3584 PF12128.6 NM_175623.3_2 - 1.5 6.1 7.7 2.1 5.6 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.9 NM_175623.3_2 - 3.2 6.4 9.3 4.9 5.8 9.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein PDZ PF00595.22 NM_001267560.1_1 - 4.5e-43 145.4 4.3 6.8e-16 58.3 0.1 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001267560.1_1 - 9.4e-20 70.6 0.7 3.2e-07 30.4 0.0 3.6 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.15 NM_001267560.1_1 - 3.2e-13 49.0 0.0 9.8e-13 47.5 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain Guanylate_kin PF00625.19 NM_001267560.1_1 - 1.1e-10 41.3 0.0 5.8e-09 35.8 0.0 2.2 1 1 1 2 2 2 1 Guanylate kinase Tricorn_PDZ PF14685.4 NM_001267560.1_1 - 0.00016 21.5 0.2 2.1 8.3 0.0 3.6 3 0 0 3 3 3 2 Tricorn protease PDZ domain OmpH PF03938.12 NM_001145018.1_2 - 0.0041 17.0 11.6 0.0041 17.0 11.6 2.4 1 1 2 3 3 3 1 Outer membrane protein (OmpH-like) DUF4407 PF14362.4 NM_001145018.1_2 - 0.015 14.6 17.5 0.021 14.1 17.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.10 NM_001145018.1_2 - 0.028 14.3 3.3 0.13 12.2 1.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.18 NM_001145018.1_2 - 0.035 14.0 2.4 0.035 14.0 2.4 3.2 1 1 2 3 3 3 0 Prefoldin subunit DUF3138 PF11336.6 NM_001145018.1_2 - 0.04 12.4 2.8 0.053 12.0 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) TolA_bind_tri PF16331.3 NM_001145018.1_2 - 0.043 13.7 16.9 0.025 14.5 11.5 3.0 1 1 1 2 2 2 0 TolA binding protein trimerisation Filament PF00038.19 NM_001145018.1_2 - 0.06 12.8 18.1 0.22 10.9 18.0 1.8 1 1 0 1 1 1 0 Intermediate filament protein Ribosomal_S25 PF03297.13 NM_001145018.1_2 - 0.068 13.3 2.1 0.14 12.2 2.1 1.5 1 0 0 1 1 1 0 S25 ribosomal protein PLAC9 PF15205.4 NM_001145018.1_2 - 0.1 12.9 0.5 0.27 11.5 0.2 1.8 2 0 0 2 2 1 0 Placenta-specific protein 9 TMCO5 PF14992.4 NM_001145018.1_2 - 0.11 12.0 7.4 0.16 11.4 7.4 1.2 1 0 0 1 1 1 0 TMCO5 family Phage_GP20 PF06810.9 NM_001145018.1_2 - 0.11 12.2 7.3 0.11 12.2 4.9 2.0 1 1 1 2 2 2 0 Phage minor structural protein GP20 ApoLp-III PF07464.9 NM_001145018.1_2 - 0.13 12.2 2.4 0.28 11.1 1.7 1.8 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) WXG100 PF06013.10 NM_001145018.1_2 - 0.14 12.3 13.3 0.44 10.7 0.8 3.5 1 1 2 3 3 3 0 Proteins of 100 residues with WXG DUF4795 PF16043.3 NM_001145018.1_2 - 0.16 11.4 9.6 0.42 10.0 9.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Baculo_PEP_C PF04513.10 NM_001145018.1_2 - 0.21 11.5 0.2 1.3 8.9 0.1 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF148 PF02520.15 NM_001145018.1_2 - 0.22 11.5 2.6 0.77 9.7 1.0 2.1 1 1 2 3 3 3 0 Domain of unknown function DUF148 TBPIP PF07106.11 NM_001145018.1_2 - 0.37 10.4 5.7 0.36 10.5 2.4 2.2 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Alanine_zipper PF11839.6 NM_001145018.1_2 - 0.38 10.9 13.5 0.16 12.1 8.8 2.3 1 1 1 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Tup_N PF08581.8 NM_001145018.1_2 - 0.41 10.8 9.8 6.9 6.9 1.6 3.2 1 1 2 3 3 3 0 Tup N-terminal DUF342 PF03961.11 NM_001145018.1_2 - 0.63 8.5 4.7 0.56 8.6 3.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF342) TMF_TATA_bd PF12325.6 NM_001145018.1_2 - 0.75 9.9 15.3 0.22 11.6 7.9 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding PKcGMP_CC PF16808.3 NM_001145018.1_2 - 0.99 9.2 8.1 6 6.7 0.7 3.2 3 0 0 3 3 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase TPR_MLP1_2 PF07926.10 NM_001145018.1_2 - 1 9.3 20.8 3.8 7.4 12.3 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Kinetocho_Slk19 PF12709.5 NM_001145018.1_2 - 1.1 9.6 5.6 6.6 7.1 0.4 3.1 2 1 1 3 3 3 0 Central kinetochore-associated TMPIT PF07851.11 NM_001145018.1_2 - 1.2 8.2 7.3 0.25 10.4 4.0 1.5 1 1 1 2 2 2 0 TMPIT-like protein COG2 PF06148.9 NM_001145018.1_2 - 1.6 8.7 5.4 11 5.9 5.1 2.2 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3584 PF12128.6 NM_001145018.1_2 - 1.9 5.7 21.6 6 4.1 21.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Phage_Mu_Gam PF07352.10 NM_001145018.1_2 - 2.1 8.1 10.4 0.62 9.8 0.7 2.5 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein YlqD PF11068.6 NM_001145018.1_2 - 2.5 8.4 14.1 0.43 10.8 3.9 2.5 1 1 1 2 2 2 0 YlqD protein Peptidase_S46 PF10459.7 NM_001145018.1_2 - 2.6 6.4 9.4 2.4 6.6 8.6 1.2 1 1 0 1 1 1 0 Peptidase S46 DUF5082 PF16888.3 NM_001145018.1_2 - 2.7 8.2 8.4 2.1 8.6 1.1 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF5082) Golgin_A5 PF09787.7 NM_001145018.1_2 - 2.8 7.2 20.2 3.1 7.0 18.3 1.8 1 1 1 2 2 2 0 Golgin subfamily A member 5 FadA PF09403.8 NM_001145018.1_2 - 4.1 7.8 13.0 7.1 7.0 7.6 2.6 1 1 1 2 2 2 0 Adhesion protein FadA LPP PF04728.11 NM_001145018.1_2 - 4.2 7.7 9.2 1.6 9.0 2.5 3.2 1 1 2 3 3 3 0 Lipoprotein leucine-zipper Spc7 PF08317.9 NM_001145018.1_2 - 5.1 5.8 17.6 4.7 5.9 15.7 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein AAA_13 PF13166.4 NM_001145018.1_2 - 5.2 5.5 8.2 0.82 8.1 3.0 1.7 1 1 0 1 1 1 0 AAA domain Med9 PF07544.11 NM_001145018.1_2 - 8.2 6.5 8.7 0.91 9.5 2.9 2.3 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF883 PF05957.11 NM_001145018.1_2 - 8.6 6.9 22.6 3.5 8.1 5.3 3.0 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) V-SNARE PF05008.13 NM_001145018.1_2 - 8.7 6.7 14.1 0.38 11.0 3.3 2.8 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Trypsin PF00089.24 NM_144957.2_2 - 1.3e-49 168.9 0.0 1.6e-49 168.6 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_144957.2_2 - 0.0048 17.7 0.0 0.0081 16.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_144957.2_2 - 0.011 16.0 0.5 0.11 12.8 0.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) Cation_efflux PF01545.19 NM_001172814.1_3 - 2.7e-42 144.6 16.6 4.3e-42 144.0 16.6 1.3 1 0 0 1 1 1 1 Cation efflux family zf-H2C2_2 PF13465.4 NM_001042415.2_1 - 6.7e-84 272.7 106.0 6.6e-10 38.9 3.3 14.5 14 1 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001042415.2_1 - 1.2e-52 173.3 121.3 4.8e-06 26.6 1.4 14.0 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001042415.2_1 - 6.9e-31 104.1 112.0 0.00051 20.5 1.2 13.7 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_001042415.2_1 - 4.2e-21 74.2 0.1 7.8e-21 73.3 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001042415.2_1 - 1e-13 51.0 72.8 0.011 16.0 0.4 12.4 11 1 1 12 12 11 8 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001042415.2_1 - 5e-12 45.3 96.8 0.0037 17.0 0.7 12.7 12 0 0 12 12 12 8 C2H2-type zinc finger GAGA PF09237.9 NM_001042415.2_1 - 2.7e-05 23.8 23.8 0.4 10.4 0.1 7.9 2 2 7 9 9 9 3 GAGA factor Zn-ribbon_8 PF09723.8 NM_001042415.2_1 - 0.00016 21.6 53.8 0.013 15.5 0.2 8.6 5 1 2 8 8 8 5 Zinc ribbon domain Ta0938 PF11494.6 NM_001042415.2_1 - 0.003 17.7 24.1 2 8.6 0.5 6.9 2 1 5 7 7 7 2 Ta0938 BolA PF01722.16 NM_001042415.2_1 - 0.0088 16.2 22.0 3.6 7.8 0.3 6.0 3 1 2 5 5 5 2 BolA-like protein BHD_1 PF10403.7 NM_001042415.2_1 - 0.026 14.2 4.1 11 5.8 0.0 4.8 4 2 0 4 4 4 0 Rad4 beta-hairpin domain 1 FYVE PF01363.19 NM_001042415.2_1 - 0.45 10.5 71.4 0.38 10.8 4.0 7.9 1 1 4 6 6 5 0 FYVE zinc finger zinc_ribbon_15 PF17032.3 NM_001042415.2_1 - 0.48 11.1 38.8 1.2 9.8 1.2 6.4 3 1 3 6 6 6 0 zinc-ribbon family Ectoine_synth PF06339.10 NM_001042415.2_2 - 0.033 14.2 0.3 0.23 11.5 0.0 2.4 1 1 0 2 2 2 0 Ectoine synthase Fur_reg_FbpB PF13040.4 NM_001042415.2_2 - 0.43 10.0 2.2 6.2 6.3 0.0 3.2 3 0 0 3 3 3 0 Fur-regulated basic protein B AMP-binding PF00501.26 NM_052956.2_3 - 9.5e-70 235.2 0.0 1.2e-69 234.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 NM_052956.2_3 - 1.2e-25 90.1 0.7 2.1e-25 89.3 0.7 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SRI PF08236.9 NM_052956.2_3 - 0.0015 18.5 0.7 0.0025 17.8 0.7 1.3 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain dNK PF01712.17 NM_080918.2_2 - 3.4e-37 128.2 0.5 3e-31 108.8 0.0 2.0 1 1 1 2 2 2 2 Deoxynucleoside kinase MMR_HSR1 PF01926.21 NM_080918.2_2 - 0.18 11.8 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF974 PF06159.11 NM_001093756.1_1 - 3e-83 279.3 0.4 4.2e-83 278.8 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Trs65 PF12735.5 NM_001093756.1_1 - 0.0066 15.8 0.0 5.4 6.2 0.0 3.0 3 0 0 3 3 3 2 TRAPP trafficking subunit Trs65 AKNA PF12443.6 NM_001317950.1_2 - 5.1e-43 145.6 0.5 2.5e-42 143.4 0.5 2.3 1 0 0 1 1 1 1 AT-hook-containing transcription factor PARG_cat PF05028.12 NM_001303487.1_2 - 4.8e-134 446.8 0.0 6.8e-134 446.3 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) PCNP PF15473.4 NM_001320399.1_3 - 2.6e-63 213.3 7.5 3.9e-63 212.7 7.5 1.2 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family Yippee-Mis18 PF03226.12 NM_018944.2_1 - 8.8e-30 102.9 7.4 1.5e-29 102.1 7.4 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Pkinase PF00069.23 NM_001170640.1_2 - 3.4e-40 137.9 0.0 4.5e-40 137.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001170640.1_2 - 9.3e-20 70.9 0.0 1.3e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_001170640.1_2 - 0.014 15.2 0.1 0.046 13.5 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_001170640.1_2 - 0.21 10.7 0.2 2.7 7.1 0.1 2.0 2 0 0 2 2 2 0 Kinase-like V-ATPase_G PF03179.13 NM_130463.3_2 - 1.9e-35 121.4 16.0 2.5e-35 121.1 16.0 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Zein-binding PF04576.13 NM_130463.3_2 - 0.29 11.3 13.2 0.44 10.7 13.2 1.3 1 0 0 1 1 1 0 Zein-binding PHO4 PF01384.18 NM_005415.4_3 - 1.7e-137 457.8 2.7 2.4e-137 457.3 2.7 1.2 1 0 0 1 1 1 1 Phosphate transporter family Katanin_con80 PF13925.4 NM_005886.2_3 - 7.2e-56 188.5 0.5 1e-55 188.0 0.5 1.2 1 0 0 1 1 1 1 con80 domain of Katanin WD40 PF00400.30 NM_005886.2_3 - 3.7e-49 163.5 5.3 8.2e-12 45.3 0.2 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_005886.2_3 - 6.2e-19 68.0 0.0 3.2e-05 24.0 0.0 5.8 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 NM_005886.2_3 - 0.02 13.7 0.0 0.18 10.6 0.0 2.4 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 NM_005886.2_3 - 0.045 12.2 0.0 25 3.2 0.0 3.3 3 1 0 3 3 3 0 Nucleoporin Nup120/160 TPR_2 PF07719.15 NM_198310.3_2 - 4.7e-30 101.1 8.0 0.0012 18.7 0.3 8.6 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.26 NM_198310.3_2 - 8.8e-27 91.7 10.6 0.00011 21.7 0.1 8.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.4 NM_198310.3_2 - 4.9e-19 68.3 10.8 2.6e-06 27.5 0.7 5.9 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.4 NM_198310.3_2 - 7e-19 66.3 5.9 0.0029 17.6 0.1 6.2 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_14 PF13428.4 NM_198310.3_2 - 2.2e-18 65.2 8.0 0.029 15.0 0.0 8.5 5 2 4 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.4 NM_198310.3_2 - 5.1e-15 54.2 11.4 0.0016 18.2 0.1 7.5 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_19 PF14559.4 NM_198310.3_2 - 2.6e-12 46.9 11.0 0.0052 17.1 0.0 5.8 4 2 3 7 7 6 4 Tetratricopeptide repeat TPR_16 PF13432.4 NM_198310.3_2 - 1e-10 42.0 5.0 0.0026 18.3 0.2 5.4 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_198310.3_2 - 1.7e-10 40.4 7.5 0.0028 17.8 0.4 8.3 8 1 1 9 9 9 2 Tetratricopeptide repeat TPR_15 PF13429.4 NM_198310.3_2 - 9.5e-08 31.4 3.8 5.2e-06 25.7 0.2 2.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_198310.3_2 - 1.3e-07 31.7 10.6 1 10.0 0.4 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_198310.3_2 - 9.5e-05 22.4 17.9 0.074 13.1 0.8 4.9 3 2 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.4 NM_198310.3_2 - 0.00016 21.2 8.8 5.5 6.6 0.1 5.4 3 1 2 5 5 5 2 TPR repeat TPR_9 PF13371.4 NM_198310.3_2 - 0.00017 21.5 2.5 0.079 13.0 0.1 4.5 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.4 NM_198310.3_2 - 0.00055 19.6 9.1 0.082 12.7 0.8 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.12 NM_198310.3_2 - 0.0017 17.7 5.7 0.045 13.0 0.3 2.8 1 1 2 3 3 3 2 Coatomer epsilon subunit PknG_TPR PF16918.3 NM_198310.3_2 - 0.026 13.1 0.0 0.058 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat NARP1 PF12569.6 NM_198310.3_2 - 0.027 13.2 5.0 0.57 8.9 0.1 3.1 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 DUF5112 PF17139.2 NM_198310.3_2 - 0.034 13.5 0.3 0.034 13.5 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5112) PPR PF01535.18 NM_198310.3_2 - 0.6 10.4 3.1 33 4.9 0.2 4.6 6 0 0 6 6 6 0 PPR repeat Mg_trans_NIPA PF05653.12 NM_001322859.1_1 - 1.7e-45 155.3 16.2 2.6e-45 154.7 16.2 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA zf-HC5HC2H PF13771.4 NM_001040444.2_3 - 3.7e-19 68.6 7.5 4.9e-19 68.2 4.2 2.5 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 NM_001040444.2_3 - 2.2e-07 30.9 7.3 7.9e-07 29.1 6.9 2.1 1 1 0 1 1 1 1 PHD-zinc-finger like domain DUF3416 PF11896.6 NM_001040444.2_3 - 0.14 12.3 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3416) PHD PF00628.27 NM_001040444.2_3 - 0.16 11.7 8.8 0.034 13.9 4.5 2.2 2 0 0 2 2 2 0 PHD-finger zf-H2C2_2 PF13465.4 NM_001318141.1_1 - 2.1e-68 223.8 98.3 3.9e-08 33.3 0.4 12.3 12 0 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001318141.1_1 - 7.1e-53 174.1 89.7 3.5e-06 27.0 1.0 11.5 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001318141.1_1 - 8.7e-29 97.6 82.2 0.0028 18.2 0.5 11.5 11 0 0 11 11 11 10 C2H2-type zinc finger KRAB PF01352.25 NM_001318141.1_1 - 1.7e-22 78.7 0.0 2.7e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001318141.1_1 - 2.7e-14 52.8 49.6 0.0038 17.2 2.3 7.5 3 1 6 9 9 9 9 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001318141.1_1 - 3.9e-13 48.8 71.3 0.00068 19.4 0.6 11.2 11 0 0 11 11 11 7 C2H2-type zinc finger XPA_N PF01286.16 NM_001318141.1_1 - 4.8e-10 39.1 40.0 2.4 8.1 0.0 11.1 11 0 0 11 11 11 4 XPA protein N-terminal zf-C2H2_11 PF16622.3 NM_001318141.1_1 - 9.4e-08 31.5 41.8 0.07 12.8 0.0 10.9 11 0 0 11 11 11 4 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 NM_001318141.1_1 - 3.9e-06 26.9 56.3 0.15 12.3 0.5 11.3 10 1 1 11 11 11 3 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001318141.1_1 - 1.1e-05 25.9 49.1 0.17 12.5 1.9 6.3 1 1 9 10 10 10 7 zinc-ribbon family zf-trcl PF13451.4 NM_001318141.1_1 - 0.00051 19.7 45.7 2.9 7.7 0.1 10.2 8 2 1 9 9 9 1 Probable zinc-ribbon domain DZR PF12773.5 NM_001318141.1_1 - 0.00072 19.4 50.8 1.6e+04 -30.5 50.8 6.3 1 1 0 1 1 0 0 Double zinc ribbon tRNA-synt_2d PF01409.18 NM_001318141.1_1 - 0.007 15.7 1.2 0.16 11.3 0.1 2.8 2 1 1 3 3 3 1 tRNA synthetases class II core domain (F) FYDLN_acid PF09538.8 NM_001318141.1_1 - 0.069 13.7 25.9 12 6.5 0.2 8.8 2 1 7 9 9 9 0 Protein of unknown function (FYDLN_acid) DUF3268 PF11672.6 NM_001318141.1_1 - 0.18 12.0 32.9 3 8.1 0.3 6.1 4 2 2 7 7 7 0 zinc-finger-containing domain zf-LYAR PF08790.9 NM_001318141.1_1 - 1.2 9.0 47.7 1.6 8.5 0.1 10.1 11 0 0 11 11 11 0 LYAR-type C2HC zinc finger FYVE PF01363.19 NM_001318141.1_1 - 2 8.4 56.2 1.1e+02 2.9 14.0 6.2 1 1 1 2 2 1 0 FYVE zinc finger DSPc PF00782.18 NM_001394.6_2 - 2.4e-44 150.2 0.1 3.5e-44 149.7 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.18 NM_001394.6_2 - 7.6e-09 35.9 0.0 2.5e-08 34.2 0.0 1.8 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.25 NM_001394.6_2 - 6.5e-05 22.5 0.0 0.0001 21.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase MRVI1 PF05781.10 NM_001206881.1_2 - 6e-212 704.9 5.6 7.8e-212 704.6 5.6 1.1 1 0 0 1 1 1 1 MRVI1 protein CD34_antigen PF06365.10 NM_001284324.1_3 - 0.13 11.7 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family SH3_2 PF07653.15 NM_006533.3_2 - 8.5e-11 41.2 0.0 1.3e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_006533.3_2 - 0.011 15.5 0.0 0.026 14.2 0.0 1.7 1 1 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.26 NM_006533.3_2 - 0.069 12.6 0.0 0.17 11.4 0.0 1.6 2 0 0 2 2 2 0 SH3 domain DUF3456 PF11938.6 NM_001190991.1_1 - 6.2e-10 39.7 0.0 8.9e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP Pea-VEAacid PF08111.9 NM_001190991.1_3 - 0.063 13.5 0.1 0.22 11.8 0.1 2.0 1 0 0 1 1 1 0 Pea-VEAacid family 60KD_IMP PF02096.18 NM_005015.3_1 - 3.4e-22 79.0 1.2 5.1e-22 78.4 1.2 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein DUF2630 PF10944.6 NM_005015.3_3 - 0.11 12.9 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) TSP_1 PF00090.17 NM_006108.3_2 - 4e-84 276.5 91.9 1.9e-17 63.1 5.7 7.4 7 0 0 7 7 7 6 Thrombospondin type 1 domain Spond_N PF06468.11 NM_006108.3_2 - 4.8e-71 238.7 0.2 1.1e-70 237.6 0.2 1.6 1 0 0 1 1 1 1 Spondin_N Reeler PF02014.14 NM_006108.3_2 - 1.2e-20 74.4 0.0 2.2e-20 73.6 0.0 1.4 1 0 0 1 1 1 1 Reeler domain Mito_carr PF00153.25 NM_001282726.1_1 - 8.1e-45 150.6 1.1 2.9e-21 75.1 0.0 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.25 NM_001282726.1_2 - 0.0083 15.9 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial carrier protein Sgf11 PF08209.9 NM_020218.1_2 - 1e-17 63.2 2.8 2.6e-17 61.9 2.8 1.8 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) SCA7 PF08313.10 NM_020218.1_2 - 3.2e-06 26.8 2.3 3.2e-06 26.8 2.3 2.5 2 0 0 2 2 2 1 SCA7, zinc-binding domain Ribosomal_S7 PF00177.19 NM_015971.3_3 - 2e-36 124.7 0.3 2.9e-36 124.2 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e RRM_1 PF00076.20 NM_001242600.1_2 - 4.1e-41 138.5 0.0 8.6e-24 83.0 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.4 NM_001242600.1_2 - 7.2e-28 97.3 0.5 2.1e-27 95.8 0.5 1.8 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.3 NM_001242600.1_2 - 0.00047 19.8 0.0 0.028 14.2 0.0 3.1 3 1 0 3 3 3 1 Occluded RNA-recognition motif RRM_5 PF13893.4 NM_001242600.1_2 - 0.023 14.2 0.0 0.57 9.6 0.0 2.3 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4700 PF15771.3 NM_001242600.1_2 - 0.024 13.3 12.9 0.037 12.7 12.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4700) RSRP PF17069.3 NM_001242600.1_2 - 0.037 13.5 44.4 0.066 12.6 44.4 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 RRM_7 PF16367.3 NM_001242600.1_2 - 0.093 12.7 0.0 0.31 11.1 0.0 1.9 1 0 0 1 1 1 0 RNA recognition motif Apt1 PF10351.7 NM_001242600.1_2 - 0.27 9.9 11.8 0.43 9.3 11.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain MIP-T3 PF10243.7 NM_001242600.1_2 - 0.27 9.8 28.5 0.4 9.2 28.5 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DDHD PF02862.15 NM_001242600.1_2 - 2.5 8.0 7.6 3.4 7.6 6.6 1.7 2 0 0 2 2 2 0 DDHD domain Erf4 PF10256.7 NM_016099.2_1 - 1.1e-32 112.5 0.0 1.6e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family MBD_C PF14048.4 NM_001281454.1_2 - 5.2e-35 119.9 0.1 1e-34 118.9 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of methyl-CpG binding protein 2 and 3 MBDa PF16564.3 NM_001281454.1_2 - 1.5e-28 98.6 1.0 2.9e-28 97.7 1.0 1.5 1 0 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD MBD PF01429.17 NM_001281454.1_2 - 8.6e-07 28.4 0.8 0.0018 17.8 0.0 2.4 1 1 0 2 2 2 2 Methyl-CpG binding domain RasGAP PF00616.17 NM_001281454.1_2 - 0.11 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase zf-C4 PF00105.16 NM_000964.3_2 - 3.9e-32 110.4 16.2 3.9e-32 110.4 16.2 1.8 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_000964.3_2 - 1.4e-22 80.2 0.0 2.1e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor MyTH4 PF00784.15 NM_172069.3_3 - 2.1e-34 118.1 1.6 2.1e-34 118.1 1.6 2.0 2 0 0 2 2 2 1 MyTH4 domain PH PF00169.27 NM_172069.3_3 - 2.6e-24 85.6 1.1 5.9e-17 62.0 0.1 2.8 2 0 0 2 2 2 2 PH domain FERM_M PF00373.16 NM_172069.3_3 - 1e-12 48.3 0.0 3.4e-12 46.7 0.0 1.9 1 0 0 1 1 1 1 FERM central domain PH_11 PF15413.4 NM_172069.3_3 - 2e-05 24.8 2.1 2e-05 24.8 2.1 3.9 3 1 0 3 3 3 1 Pleckstrin homology domain Exonuc_VII_L PF02601.13 NM_172069.3_3 - 9.5 5.5 15.2 18 4.6 15.2 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3402 PF11882.6 NM_001134336.1_2 - 8.8e-88 295.3 19.0 9.7e-52 176.5 5.6 3.1 1 1 2 3 3 3 3 Domain of unknown function (DUF3402) N1221 PF07923.11 NM_001134336.1_2 - 2.7e-52 177.6 0.0 4e-52 177.1 0.0 1.2 1 0 0 1 1 1 1 N1221-like protein DeoC PF01791.7 NM_001300779.1_3 - 2.3e-13 50.2 0.0 7.5e-07 28.9 0.0 2.1 1 1 1 2 2 2 2 DeoC/LacD family aldolase RGS-like PF09128.9 NM_199002.1_3 - 5e-72 241.4 0.1 5e-72 241.4 0.1 1.8 2 0 0 2 2 2 1 Regulator of G protein signalling-like domain RhoGEF PF00621.18 NM_199002.1_3 - 1e-36 126.8 0.3 2e-36 125.8 0.3 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.3 NM_199002.1_3 - 0.0022 17.8 0.1 0.0046 16.7 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PUF PF00806.17 NM_001282752.1_2 - 1.7e-71 232.0 9.5 2.1e-09 36.4 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.9 NM_001282752.1_2 - 0.09 13.0 1.4 8.4 6.6 0.1 3.5 1 1 2 3 3 3 0 CPL (NUC119) domain TLE_N PF03920.13 NM_001300846.1_1 - 1.5e-69 232.0 6.1 2.4e-69 231.3 6.1 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.30 NM_001300846.1_1 - 8.2e-19 67.5 18.8 0.014 16.1 0.3 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001300846.1_1 - 7.4e-07 29.3 0.0 0.49 10.6 0.0 4.0 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_001300846.1_1 - 0.0095 15.2 0.0 1.4 8.0 0.1 2.4 2 1 0 2 2 2 2 WD40-like domain HALZ PF02183.16 NM_001300846.1_1 - 0.041 13.9 0.3 0.085 12.9 0.3 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper UTP15_C PF09384.8 NM_001284431.1_2 - 2.6e-47 160.2 0.1 3.5e-47 159.8 0.1 1.2 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.30 NM_001284431.1_2 - 4.1e-26 90.6 1.2 2.8e-06 27.8 0.1 6.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001284431.1_2 - 5.2e-09 36.1 0.0 0.0039 17.3 0.0 4.0 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.23 NM_003952.2_2 - 2.1e-69 233.7 0.0 2.8e-69 233.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_003952.2_2 - 2.9e-34 118.4 0.0 3.7e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 NM_003952.2_2 - 6.3e-10 39.4 2.8 6.3e-10 39.4 2.8 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_003952.2_2 - 0.00012 21.3 0.0 0.00021 20.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.4 NM_003952.2_2 - 0.0059 16.1 0.0 1.8 8.0 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.9 NM_003952.2_2 - 0.2 10.5 0.0 0.4 9.5 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 7tm_4 PF13853.4 NM_001079935.1_1 - 4.5e-48 164.2 17.5 5.8e-48 163.9 17.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001079935.1_1 - 5.2e-26 91.3 17.8 1.8e-25 89.5 17.8 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001079935.1_1 - 6.5e-08 32.1 15.5 1.2e-07 31.3 15.5 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001079935.1_1 - 0.026 13.7 15.7 0.032 13.4 15.0 1.5 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Ion_trans PF00520.29 NM_147204.2_2 - 1.7e-14 53.5 21.2 2.4e-14 53.0 21.2 1.1 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.5 NM_147204.2_2 - 9.3e-13 48.4 0.3 0.00012 22.5 0.3 2.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 NM_147204.2_2 - 5.8e-09 35.9 0.2 0.00027 21.1 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.4 NM_147204.2_2 - 1.7e-07 30.8 0.3 0.012 15.9 0.0 4.6 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.4 NM_147204.2_2 - 9.1e-07 29.0 0.5 0.062 13.6 0.0 4.0 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_147204.2_2 - 1.5e-06 28.5 0.4 0.14 12.6 0.1 3.7 1 1 2 4 4 4 3 Ankyrin repeats (many copies) Mit_proteolip PF08039.9 NM_003762.4_1 - 0.25 11.6 5.8 0.54 10.5 5.8 1.5 1 0 0 1 1 1 0 Mitochondrial proteolipid Synaptobrevin PF00957.19 NM_003762.4_2 - 2.2e-31 107.4 5.4 2.2e-31 107.4 5.4 1.8 2 0 0 2 2 2 1 Synaptobrevin Mit_proteolip PF08039.9 NM_003762.4_2 - 1.2 9.3 6.9 3 8.1 6.9 1.6 1 0 0 1 1 1 0 Mitochondrial proteolipid Kringle PF00051.16 NM_002665.4_1 - 9e-09 35.4 2.3 2.1e-08 34.2 2.3 1.6 1 0 0 1 1 1 1 Kringle domain PAN_1 PF00024.24 NM_002665.4_2 - 6.9e-13 48.2 1.0 1.5e-12 47.2 1.0 1.5 1 0 0 1 1 1 1 PAN domain Kringle PF00051.16 NM_002665.4_2 - 8.2e-08 32.3 0.3 1.7e-07 31.3 0.3 1.5 1 0 0 1 1 1 1 Kringle domain Pyrophosphatase PF00719.17 NM_006903.4_3 - 9.6e-41 139.1 0.4 7.4e-26 90.7 0.0 2.1 1 1 1 2 2 2 2 Inorganic pyrophosphatase Kelch_1 PF01344.23 NM_001323263.1_2 - 6.5e-32 108.7 14.5 2e-08 33.5 0.0 6.6 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.4 NM_001323263.1_2 - 2.2e-29 100.6 8.9 8e-06 25.8 0.0 7.4 4 2 2 6 6 6 5 Kelch motif BACK PF07707.13 NM_001323263.1_2 - 8.9e-17 61.0 2.1 2.3e-16 59.6 2.1 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 NM_001323263.1_2 - 9.3e-17 60.7 1.8 0.036 14.2 0.0 6.6 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_001323263.1_2 - 3e-15 55.4 1.9 0.0029 17.4 0.0 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.4 NM_001323263.1_2 - 5e-15 55.0 0.8 0.0021 17.8 0.0 6.3 5 1 1 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_001323263.1_2 - 1.3e-10 40.8 2.9 0.049 13.5 0.1 6.1 6 0 0 6 6 6 4 Kelch motif BTB PF00651.29 NM_001323263.1_2 - 1.6e-07 31.4 0.2 8.4e-07 29.1 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain Glyco_transf_7N PF13733.4 NM_003778.3_3 - 1.2e-59 199.6 0.2 1.9e-59 199.0 0.2 1.4 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 NM_003778.3_3 - 7.7e-27 92.6 0.3 1.7e-26 91.6 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase SWIM PF04434.15 NM_080752.3_3 - 5.7e-09 35.3 1.0 5.7e-09 35.3 1.0 2.0 2 0 0 2 2 2 1 SWIM zinc finger MULE PF10551.7 NM_080752.3_3 - 4.7e-05 23.7 0.1 0.00012 22.4 0.1 1.6 1 0 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.15 NM_080752.3_3 - 0.00093 18.9 0.1 0.0022 17.6 0.1 1.6 1 0 0 1 1 1 1 Transposase PAH PF02671.19 NM_080752.3_3 - 5.7 7.0 5.5 7 6.8 0.0 3.1 3 0 0 3 3 3 0 Paired amphipathic helix repeat KCNQ_channel PF03520.12 NM_172163.2_2 - 6.3e-88 293.5 0.4 8.8e-88 293.0 0.4 1.2 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel Ion_trans PF00520.29 NM_172163.2_2 - 1.6e-26 92.9 10.9 2.7e-26 92.2 10.9 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 NM_172163.2_2 - 5.1e-14 51.9 4.6 5.1e-14 51.9 4.6 1.9 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.10 NM_172163.2_2 - 0.39 9.2 9.2 0.77 8.2 9.2 1.3 1 1 0 1 1 1 0 Polycystin cation channel MgtE PF01769.14 NM_172163.2_2 - 2 8.7 4.9 1.1 9.5 0.9 2.2 2 0 0 2 2 2 0 Divalent cation transporter HMG_box PF00505.17 NM_004189.3_2 - 3.1e-28 97.8 5.0 5.4e-28 97.1 5.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_004189.3_2 - 1e-11 45.1 2.8 1.7e-11 44.4 2.8 1.3 1 0 0 1 1 1 1 HMG-box domain SOXp PF12336.6 NM_004189.3_2 - 4.7e-06 27.4 1.2 2.3e-05 25.2 0.4 2.4 2 1 0 2 2 2 1 SOX transcription factor Vinculin PF01044.17 NM_001323991.1_3 - 3.1e-211 704.2 23.7 3.9e-211 703.8 23.7 1.0 1 0 0 1 1 1 1 Vinculin family I_LWEQ PF01608.15 NM_001323991.1_3 - 0.2 11.7 0.1 0.2 11.7 0.1 5.2 3 3 2 5 5 5 0 I/LWEQ domain Tom37 PF10568.7 NM_006554.4_2 - 1.5e-29 102.7 0.0 2.6e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.2 NM_006554.4_2 - 3.1e-24 85.5 0.0 5.7e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.2 NM_006554.4_2 - 1.1e-23 82.7 0.2 2.1e-23 81.8 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 NM_006554.4_2 - 1.4e-05 24.8 0.0 3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TRADD_N PF09034.8 NM_006554.4_2 - 0.057 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 TRADD, N-terminal domain GST_C_3 PF14497.4 NM_006554.4_2 - 0.068 13.2 0.3 0.16 12.1 0.1 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain CS PF04969.14 NM_006601.6_2 - 6.6e-09 36.5 0.0 1.1e-08 35.8 0.0 1.4 1 0 0 1 1 1 1 CS domain Pkinase_C PF00433.22 NM_006601.6_2 - 2.2 8.9 5.3 5 7.8 5.3 1.6 1 0 0 1 1 1 0 Protein kinase C terminal domain Rrn6 PF10214.7 NM_006601.6_3 - 1.4 7.1 7.6 1.9 6.6 7.6 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor MITF_TFEB_C_3_N PF15951.3 NM_001271945.1_1 - 5.1e-66 221.9 11.7 5.1e-66 221.9 11.7 2.0 2 0 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 NM_001271945.1_1 - 9e-35 120.3 5.9 9e-35 120.3 5.9 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF3371) HLH PF00010.24 NM_001271945.1_1 - 2.7e-15 55.9 0.7 6e-15 54.8 0.7 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SR-25 PF10500.7 NM_001271945.1_3 - 0.037 13.5 24.4 0.05 13.1 24.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4604 PF15377.4 NM_001271945.1_3 - 0.31 11.3 18.0 0.49 10.7 18.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) GBP_C PF02841.12 NM_052941.4_3 - 7.5e-127 422.7 28.3 9.7e-127 422.3 28.3 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain GBP PF02263.17 NM_052941.4_3 - 5.7e-119 396.0 0.0 5.7e-119 396.0 0.0 2.2 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.21 NM_052941.4_3 - 0.012 15.6 0.0 0.032 14.2 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Phlebovirus_NSM PF07246.9 NM_052941.4_3 - 2.8 7.1 14.5 5 6.3 14.5 1.3 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Helitron_like_N PF14214.4 NM_052941.4_3 - 3 7.8 8.2 2.5 8.1 6.1 1.9 2 0 0 2 2 2 0 Helitron helicase-like domain at N-terminus DUF1664 PF07889.10 NM_052941.4_3 - 4.2 7.2 9.5 10 6.0 9.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Glyco_transf_29 PF00777.16 NM_174968.3_3 - 1.3e-68 231.2 0.0 1.6e-68 230.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Amidohydro_1 PF01979.18 NM_001242505.2_3 - 1.6e-74 251.1 0.0 2.1e-74 250.8 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 NM_001242505.2_3 - 3.2e-10 39.9 0.0 1.1e-07 31.6 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family I-set PF07679.14 NM_001178145.1_2 - 4.3e-95 311.8 0.0 3.6e-15 55.7 0.0 7.2 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001178145.1_2 - 1.2e-91 301.2 5.8 4.9e-14 52.6 0.1 7.3 7 0 0 7 7 7 7 Immunoglobulin domain ig PF00047.23 NM_001178145.1_2 - 5.5e-64 212.2 0.0 2e-10 40.5 0.0 7.3 7 0 0 7 7 7 7 Immunoglobulin domain Ig_2 PF13895.4 NM_001178145.1_2 - 2.7e-50 168.5 0.9 7.9e-08 32.4 0.0 7.4 7 0 0 7 7 7 7 Immunoglobulin domain V-set PF07686.15 NM_001178145.1_2 - 1.7e-31 108.5 6.9 0.0016 18.4 0.0 10.3 7 4 0 7 7 7 7 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001178145.1_2 - 1.5e-12 47.3 0.6 0.37 10.8 0.1 6.3 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 NM_001178145.1_2 - 1.4e-06 28.1 0.7 11 6.0 0.0 6.8 8 0 0 8 8 8 1 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 NM_001178145.1_2 - 0.00037 20.5 0.1 1.9 8.6 0.0 5.0 6 0 0 6 6 6 1 Natural killer cell receptor 2B4 C2-set PF05790.13 NM_001178145.1_2 - 0.0077 16.3 0.0 1 9.5 0.0 4.3 4 1 0 4 4 4 1 Immunoglobulin C2-set domain VCX_VCY PF15231.4 NM_016379.3_2 - 1.4e-82 275.2 50.8 1.6e-72 242.6 31.4 2.1 1 1 1 2 2 2 2 Variable charge X/Y family GKAP PF03359.11 NM_014750.4_2 - 3.9e-30 105.5 0.6 3.9e-30 105.5 0.6 2.8 3 0 0 3 3 3 1 Guanylate-kinase-associated protein (GKAP) protein Ldh_1_N PF00056.21 NM_005566.3_3 - 3.6e-50 169.6 0.7 5e-50 169.1 0.7 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 NM_005566.3_3 - 1e-23 84.0 0.0 1.8e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Pyr_redox_2 PF07992.12 NM_005566.3_3 - 0.034 13.3 0.0 0.051 12.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_4 PF02056.14 NM_005566.3_3 - 0.071 12.5 0.7 0.13 11.7 0.0 1.7 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase Arm PF00514.21 NM_001320611.1_3 - 1.8e-86 281.7 5.0 3.4e-11 42.7 0.0 8.6 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.18 NM_001320611.1_3 - 1.4e-30 105.3 5.1 3.7e-30 104.0 5.1 1.8 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.3 NM_001320611.1_3 - 2.1e-24 84.7 2.4 3.9e-24 83.8 2.4 1.5 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.4 NM_001320611.1_3 - 1.1e-19 70.3 0.3 3.1e-06 27.4 0.0 5.3 3 2 2 5 5 5 3 HEAT-like repeat HEAT_2 PF13646.4 NM_001320611.1_3 - 1.8e-11 44.1 0.6 0.013 15.8 0.0 5.9 3 1 5 8 8 8 4 HEAT repeats HEAT PF02985.20 NM_001320611.1_3 - 5.1e-08 32.4 0.3 0.17 12.1 0.0 5.7 6 0 0 6 6 6 2 HEAT repeat V-ATPase_H_C PF11698.6 NM_001320611.1_3 - 0.0001 22.3 0.0 0.23 11.5 0.1 3.0 2 1 1 3 3 3 2 V-ATPase subunit H Cnd1 PF12717.5 NM_001320611.1_3 - 0.0063 16.4 0.0 1.4 8.7 0.0 3.6 2 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.18 NM_001320611.1_3 - 0.016 13.7 0.0 0.075 11.4 0.0 2.2 1 1 0 1 1 1 0 Adaptin N terminal region SEN1_N PF12726.5 NM_001320611.1_3 - 0.017 13.3 0.1 21 3.0 0.1 3.7 4 0 0 4 4 4 0 SEN1 N terminal DUF3554 PF12074.6 NM_001320611.1_3 - 0.058 12.5 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3554) JmjC PF02373.20 NM_001318154.1_3 - 2.3e-11 44.0 0.0 1.6e-10 41.3 0.0 2.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-C5HC2 PF02928.14 NM_001318154.1_3 - 0.018 15.3 4.4 0.046 13.9 4.4 1.7 1 0 0 1 1 1 0 C5HC2 zinc finger C1_2 PF03107.14 NM_001318154.1_3 - 0.09 13.0 5.0 0.3 11.3 5.0 1.9 1 0 0 1 1 1 0 C1 domain zf-UBP PF02148.17 NM_001318154.1_3 - 0.64 10.3 6.7 1.9 8.7 6.7 1.8 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein FYVE PF01363.19 NM_001318154.1_3 - 0.87 9.6 6.3 2.7 8.1 6.3 1.8 1 0 0 1 1 1 0 FYVE zinc finger RbpA PF13397.4 NM_001318154.1_3 - 4.8 7.7 10.7 2.9 8.4 0.5 3.9 3 0 0 3 3 3 0 RNA polymerase-binding protein RabGAP-TBC PF00566.16 NM_032258.4_1 - 9.5e-38 129.9 0.0 1.3e-37 129.4 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain zf-C2H2_6 PF13912.4 NM_033502.3_3 - 6.8e-15 54.5 5.9 8.6e-05 22.3 0.2 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_4 PF13894.4 NM_033502.3_3 - 7.8e-09 35.5 10.8 0.057 14.1 0.1 5.1 4 0 0 4 4 4 3 C2H2-type zinc finger ELM2 PF01448.22 NM_033502.3_3 - 1.6e-06 28.6 0.0 1.6e-06 28.6 0.0 3.0 3 0 0 3 3 3 1 ELM2 domain zf-C2H2 PF00096.24 NM_033502.3_3 - 5.7e-06 26.4 19.8 0.058 13.7 1.2 5.6 5 0 0 5 5 5 3 Zinc finger, C2H2 type Myb_DNA-binding PF00249.29 NM_033502.3_3 - 0.0012 18.8 0.1 0.0027 17.7 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-CW PF07496.13 NM_033502.3_3 - 0.0055 16.6 0.3 0.015 15.2 0.3 1.8 1 0 0 1 1 1 1 CW-type Zinc Finger zf-C2H2_jaz PF12171.6 NM_033502.3_3 - 0.0086 16.2 1.7 2.7 8.3 0.7 3.7 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 NM_033502.3_3 - 0.026 14.7 8.7 0.086 13.1 0.0 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) Sigma70_ner PF04546.11 NM_033502.3_3 - 0.061 13.1 2.1 0.14 11.8 2.1 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region Myb_DNA-bind_7 PF15963.3 NM_033502.3_3 - 0.88 9.4 4.9 0.11 12.3 0.2 1.8 2 0 0 2 2 2 0 Myb DNA-binding like CAP_N PF01213.17 NM_001195571.1_2 - 3.9 6.7 6.0 6.8 5.9 6.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Cornifin PF02389.13 NM_001195571.1_3 - 1.9 8.6 41.9 4.6 7.3 41.9 1.6 1 1 0 1 1 1 0 Cornifin (SPRR) family His_Phos_1 PF00300.20 NM_000290.3_2 - 8.5e-35 120.1 0.1 1.1e-27 96.9 0.1 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) WD40 PF00400.30 NM_003610.3_3 - 2e-11 44.1 16.7 0.00085 20.0 0.2 5.7 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_003610.3_3 - 0.00077 19.6 0.0 0.19 11.9 0.0 3.1 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_003610.3_3 - 0.02 13.4 0.5 0.8 8.1 0.1 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 SET PF00856.26 NM_006062.2_3 - 4.7e-12 46.5 0.0 1.2e-11 45.1 0.0 1.7 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.16 NM_006062.2_3 - 0.0032 17.4 9.1 0.0032 17.4 9.1 2.7 3 1 0 3 3 3 1 MYND finger zf-HIT PF04438.14 NM_006062.2_3 - 1.4 8.7 9.9 0.13 12.0 3.6 2.4 2 0 0 2 2 2 0 HIT zinc finger zf-H2C2_2 PF13465.4 NM_001253800.1_1 - 7.5e-87 282.1 104.5 2.2e-08 34.0 2.1 13.9 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001253800.1_1 - 1.1e-44 148.2 94.9 5.8e-05 23.2 1.1 13.5 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_001253800.1_1 - 2.5e-25 87.8 93.7 0.00094 18.9 0.5 13.2 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_001253800.1_1 - 3.9e-25 87.1 0.9 7e-25 86.3 0.9 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001253800.1_1 - 2e-22 77.8 98.1 0.0035 17.9 0.8 14.1 13 0 0 13 13 13 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001253800.1_1 - 1e-14 54.2 61.1 0.002 18.1 1.0 7.7 6 2 0 6 6 6 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001253800.1_1 - 3.3e-07 30.3 61.8 0.33 11.2 1.0 12.6 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001253800.1_1 - 0.19 12.4 52.7 0.59 10.8 1.3 7.1 2 1 6 8 8 8 0 zinc-ribbon family zf-trcl PF13451.4 NM_001253800.1_1 - 0.21 11.4 58.0 4.5 7.1 0.1 11.6 10 2 0 10 10 10 0 Probable zinc-ribbon domain XPA_N PF01286.16 NM_001253800.1_1 - 2.6 8.0 58.9 8 6.5 0.0 12.2 12 0 0 12 12 12 0 XPA protein N-terminal ATP_synth_reg PF14960.4 NM_001206426.1_1 - 1.8e-28 97.6 0.2 3.7e-28 96.7 0.2 1.5 1 0 0 1 1 1 1 ATP synthase regulation DED PF01335.19 NM_001297576.1_1 - 7.1e-19 67.7 0.2 1.2e-18 67.0 0.2 1.4 1 0 0 1 1 1 1 Death effector domain Cgr1 PF03879.12 NM_024098.3_2 - 6.6e-16 58.5 31.1 1.2e-15 57.7 31.1 1.3 1 0 0 1 1 1 1 Cgr1 family AGOG PF09171.8 NM_024098.3_2 - 4.6 6.3 6.5 6.6 5.8 6.5 1.1 1 0 0 1 1 1 0 N-glycosylase/DNA lyase Transposase_1 PF01359.16 NM_015599.2_1 - 1.5e-27 95.1 0.1 5.4e-27 93.3 0.1 1.9 2 0 0 2 2 2 1 Transposase (partial DDE domain) PGM_PMM_I PF02878.14 NM_015599.2_1 - 5.2e-17 61.7 0.0 3.5e-07 29.9 0.0 2.4 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.18 NM_015599.2_1 - 1.4e-10 41.1 0.1 2.9e-10 40.1 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.14 NM_015599.2_1 - 0.0029 17.6 0.1 0.0055 16.8 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Ribosomal_L22 PF00237.17 NM_015599.2_1 - 0.19 12.1 0.6 0.38 11.1 0.6 1.4 1 0 0 1 1 1 0 Ribosomal protein L22p/L17e Guanylate_kin PF00625.19 NM_001128827.2_3 - 4.5e-68 228.4 0.1 6.4e-68 227.9 0.1 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 NM_001128827.2_3 - 4.2e-66 219.2 10.1 1.9e-21 76.0 0.1 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_assoc PF10600.7 NM_001128827.2_3 - 7.9e-27 93.8 6.5 7.9e-27 93.8 6.5 2.6 2 0 0 2 2 2 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 NM_001128827.2_3 - 2.2e-18 66.2 1.7 1.1e-06 28.7 0.0 3.4 3 0 0 3 3 3 3 PDZ domain MAGUK_N_PEST PF10608.7 NM_001128827.2_3 - 6.4e-16 58.8 5.9 3.1e-12 46.9 1.3 2.6 1 1 1 2 2 2 2 Polyubiquitination (PEST) N-terminal domain of MAGUK SH3_1 PF00018.26 NM_001128827.2_3 - 1.9e-08 33.6 0.0 4.3e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001128827.2_3 - 9.9e-08 31.4 0.0 2.7e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_001128827.2_3 - 0.0034 17.1 0.1 0.0082 15.8 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain Cadherin PF00028.15 NM_001291956.1_2 - 1.8e-80 265.4 5.1 2.2e-18 66.3 0.3 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 NM_001291956.1_2 - 5.1e-52 175.5 2.4 5.5e-52 175.4 0.9 1.7 2 0 0 2 2 2 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 NM_001291956.1_2 - 7e-10 38.8 2.2 0.017 15.0 0.0 4.9 5 0 0 5 5 5 3 Cadherin-like Cadherin_2 PF08266.10 NM_001291956.1_2 - 0.00028 20.5 0.0 1.3 8.7 0.0 4.1 4 0 0 4 4 4 1 Cadherin-like ASFV_J13L PF05568.9 NM_001291956.1_2 - 0.1 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Atrophin-1 PF03154.13 NM_001291956.1_3 - 8 4.5 11.4 10 4.1 11.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family Trypsin PF00089.24 NM_006610.3_3 - 2.6e-56 190.8 0.0 3.8e-56 190.2 0.0 1.3 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 NM_006610.3_3 - 5e-45 152.2 0.0 6.4e-29 100.4 0.1 2.8 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 NM_006610.3_3 - 4.8e-21 75.0 14.5 1.6e-10 41.3 0.3 3.5 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) EGF_CA PF07645.13 NM_006610.3_3 - 4e-07 30.0 5.2 4e-07 30.0 5.2 2.8 3 0 0 3 3 3 1 Calcium-binding EGF domain FXa_inhibition PF14670.4 NM_006610.3_3 - 1.9e-05 24.7 8.6 1.9e-05 24.7 8.6 2.8 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.5 NM_006610.3_3 - 0.0029 17.4 2.8 0.0029 17.4 2.8 3.4 4 0 0 4 4 4 1 Complement Clr-like EGF-like CUB_2 PF02408.18 NM_006610.3_3 - 0.016 14.8 0.0 0.081 12.6 0.0 2.0 2 0 0 2 2 2 0 CUB-like domain F-box-like PF12937.5 NM_017703.2_3 - 6.7e-14 51.4 4.5 1.7e-13 50.1 4.5 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_017703.2_3 - 3.2e-11 42.7 4.7 1.1e-10 41.0 4.7 2.0 1 0 0 1 1 1 1 F-box domain DOCK-C2 PF14429.4 NM_001130050.1_2 - 1.3e-53 181.6 0.1 3.2e-53 180.3 0.1 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 NM_001130050.1_2 - 3.7e-33 113.6 0.2 9.3e-33 112.3 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.27 NM_001130050.1_2 - 3.1e-13 50.0 0.2 6.7e-13 48.9 0.2 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 NM_001130050.1_2 - 0.0003 21.0 0.0 0.00071 19.8 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain OAD_gamma PF04277.11 NM_001301082.1_1 - 5.5 7.5 6.2 10 6.7 6.2 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain CAF1 PF04857.18 NM_001301082.1_3 - 1.9e-10 40.3 0.9 1.1e-08 34.5 0.1 2.9 2 1 0 3 3 3 2 CAF1 family ribonuclease MBT PF02820.16 NM_032107.4_2 - 1.3e-94 310.5 1.6 9.9e-33 112.2 0.2 3.4 3 0 0 3 3 3 3 mbt repeat zf-C2HC PF01530.16 NM_032107.4_2 - 1.6e-14 53.6 10.2 1.6e-14 53.6 10.2 2.5 2 0 0 2 2 2 1 Zinc finger, C2HC type SLAIN PF15301.4 NM_020846.1_1 - 5.4e-169 562.9 36.6 7.7e-169 562.4 36.6 1.2 1 0 0 1 1 1 1 SLAIN motif-containing family GIT_CC PF16559.3 NM_020846.1_1 - 0.42 10.5 4.8 0.53 10.2 3.2 2.0 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor bZIP_1 PF00170.19 NM_020846.1_1 - 1.1 9.3 5.0 0.24 11.4 1.1 1.9 2 0 0 2 2 2 0 bZIP transcription factor SSB PF00436.23 NM_003143.2_2 - 5.2e-31 106.6 0.1 6.9e-31 106.3 0.1 1.2 1 0 0 1 1 1 1 Single-strand binding protein family RhoGAP PF00620.25 NM_004491.4_1 - 7e-51 171.9 0.3 1.3e-50 171.0 0.3 1.4 1 0 0 1 1 1 1 RhoGAP domain RhoGAP-FF1 PF16512.3 NM_004491.4_1 - 2.7e-27 95.1 12.6 1.4e-26 92.9 6.3 3.4 3 0 0 3 3 3 1 p190-A and -B Rho GAPs FF domain Ras PF00071.20 NM_004491.4_1 - 8.1e-10 38.4 0.1 2.7e-05 23.7 0.1 3.8 4 0 0 4 4 4 2 Ras family FF PF01846.17 NM_004491.4_1 - 2.9e-07 30.4 5.9 1.7e-06 28.0 1.2 2.7 2 0 0 2 2 2 1 FF domain NOG1 PF06858.12 NM_004491.4_1 - 0.095 12.4 0.1 0.23 11.1 0.1 1.6 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) Glyco_hydro_35 PF01301.17 NM_001286423.1_2 - 2.4e-118 395.2 0.0 3.1e-118 394.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.13 NM_001286423.1_2 - 4.3e-11 42.6 0.1 7.6e-10 38.5 0.1 2.0 1 1 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.4 NM_001286423.1_2 - 0.0056 17.1 0.7 0.031 14.7 0.1 2.3 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain Colicin PF01024.17 NM_001286561.1_2 - 1 9.1 15.2 12 5.6 0.2 4.3 3 0 0 3 3 3 0 Colicin pore forming domain Macro PF01661.19 NM_001146105.1_2 - 2.1e-48 163.1 0.5 1.4e-30 105.6 0.1 2.4 2 0 0 2 2 2 2 Macro domain PARP PF00644.18 NM_001146105.1_2 - 3.5e-05 23.4 0.0 0.0012 18.4 0.0 2.6 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain ENTH PF01417.18 NM_001130072.1_1 - 7.7e-52 174.5 0.2 1.1e-51 173.9 0.2 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.14 NM_001130072.1_1 - 3.5e-05 22.8 0.3 4.9e-05 22.3 0.3 1.1 1 0 0 1 1 1 1 ANTH domain UIM PF02809.18 NM_001130072.1_1 - 0.0018 18.0 25.8 0.022 14.5 3.2 3.5 3 0 0 3 3 3 2 Ubiquitin interaction motif VHS PF00790.17 NM_001130072.1_1 - 0.0059 16.3 0.2 0.009 15.7 0.2 1.2 1 0 0 1 1 1 1 VHS domain DUF89 PF01937.17 NM_024573.2_1 - 4e-124 414.1 0.5 4.8e-124 413.8 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Phage_fiber PF03335.11 NM_001253852.2_2 - 0.5 10.5 2.6 1.3 9.2 2.6 1.8 1 0 0 1 1 1 0 Phage tail fibre repeat Adaptin_N PF01602.18 NM_001253852.2_3 - 1.5e-86 290.9 0.0 2e-86 290.5 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 NM_001253852.2_3 - 9.9e-35 119.8 0.0 5.6e-34 117.3 0.0 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.8 NM_001253852.2_3 - 9.9e-27 93.1 0.1 1.7e-26 92.3 0.1 1.4 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.4 NM_001253852.2_3 - 4.8e-08 33.2 0.0 0.011 16.0 0.0 4.9 3 2 3 6 6 6 3 HEAT repeats HEAT PF02985.20 NM_001253852.2_3 - 1.2e-07 31.2 4.1 0.74 10.1 0.1 5.8 6 0 0 6 6 6 3 HEAT repeat RTP1_C1 PF10363.7 NM_001253852.2_3 - 0.12 12.4 0.1 3.5 7.7 0.0 3.4 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 7tm_1 PF00001.19 NM_001012722.1_3 - 1.1e-23 83.7 0.0 1.2e-23 83.6 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001012722.1_3 - 0.12 11.6 0.0 0.12 11.6 0.0 2.1 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx Pkinase PF00069.23 NM_001012418.3_1 - 1e-71 241.2 0.1 1.4e-71 240.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001012418.3_1 - 4.7e-37 127.5 0.1 6.2e-37 127.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_001012418.3_1 - 0.00014 21.2 0.3 0.00022 20.5 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_001012418.3_1 - 0.058 12.6 0.0 0.086 12.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Ion_trans_2 PF07885.14 NM_005714.1_3 - 1e-19 70.2 0.2 2e-12 46.8 0.1 2.3 2 0 0 2 2 2 2 Ion channel PFK PF00365.18 NM_000289.5_3 - 2.6e-201 666.6 6.8 3.2e-109 364.5 0.8 2.2 2 0 0 2 2 2 2 Phosphofructokinase Phage_TAC_14 PF16462.3 NM_000289.5_3 - 0.13 12.4 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC FAM47 PF14642.4 NM_001013736.2_2 - 0 1213.6 239.7 2.4e-154 512.2 18.1 11.0 1 1 11 12 12 12 12 FAM47 family Drf_FH1 PF06346.10 NM_001013736.2_2 - 1.4e-11 44.2 163.7 0.0042 16.6 28.3 6.7 1 1 5 6 6 6 5 Formin Homology Region 1 DUF1610 PF07754.9 NM_001013736.2_2 - 3.4e-06 26.8 40.1 6.2 6.7 0.1 12.0 10 0 0 10 10 10 7 Domain of unknown function (DUF1610) Hormone_1 PF00103.18 NM_001163558.2_3 - 1.5e-78 263.3 0.7 1.8e-78 263.1 0.7 1.0 1 0 0 1 1 1 1 Somatotropin hormone family LRR_8 PF13855.4 NM_001135057.2_3 - 4.8e-71 234.3 57.1 2.2e-15 56.0 3.5 7.5 2 1 5 7 7 7 7 Leucine rich repeat LRR_5 PF13306.4 NM_001135057.2_3 - 2.3e-33 114.8 0.0 1.6e-13 50.6 0.0 3.4 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_001135057.2_3 - 3.4e-26 90.6 58.9 4.6e-06 26.7 0.6 9.0 5 1 6 11 11 11 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_001135057.2_3 - 1.4e-10 40.8 23.1 0.0027 17.1 1.9 5.6 1 1 5 6 6 6 6 Leucine-rich repeat LRR_1 PF00560.31 NM_001135057.2_3 - 8.5e-06 25.4 50.5 0.31 11.5 0.2 12.4 11 1 0 11 11 11 5 Leucine Rich Repeat ig PF00047.23 NM_001004196.3_3 - 6.8e-22 77.3 1.5 1.9e-12 47.1 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001004196.3_3 - 4e-09 36.8 0.7 0.0015 18.9 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_001004196.3_3 - 1.8e-06 28.0 0.1 4.1e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 NM_001004196.3_3 - 4.5e-05 23.3 0.3 0.016 15.1 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.10 NM_001004196.3_3 - 0.0036 17.2 0.3 0.021 14.7 0.1 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Mnd1 PF03962.13 NM_032117.3_3 - 1.5e-70 236.7 7.0 1.8e-70 236.5 7.0 1.1 1 0 0 1 1 1 1 Mnd1 family DivIC PF04977.13 NM_032117.3_3 - 8.8e-05 22.1 9.7 0.0013 18.3 2.2 3.3 1 1 2 3 3 3 2 Septum formation initiator Penicillinase_R PF03965.14 NM_032117.3_3 - 0.0002 21.5 0.5 0.00033 20.9 0.5 1.3 1 0 0 1 1 1 1 Penicillinase repressor TBPIP PF07106.11 NM_032117.3_3 - 0.0003 20.5 5.4 0.00039 20.1 5.0 1.3 1 1 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DsrD PF08679.9 NM_032117.3_3 - 0.023 14.8 0.1 0.054 13.6 0.1 1.6 1 0 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) TrmB PF01978.17 NM_032117.3_3 - 0.046 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB TFIIE_alpha PF02002.15 NM_032117.3_3 - 0.054 13.2 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 TFIIE alpha subunit SOGA PF11365.6 NM_032117.3_3 - 0.061 14.3 1.6 0.061 14.3 1.6 2.0 1 1 1 2 2 2 0 Protein SOGA RasGAP_C PF03836.13 NM_032117.3_3 - 0.15 12.0 3.9 0.14 12.2 2.0 1.9 1 1 1 2 2 2 0 RasGAP C-terminus DUF2959 PF11172.6 NM_032117.3_3 - 0.17 11.7 4.1 0.36 10.7 4.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) APG6 PF04111.10 NM_032117.3_3 - 0.24 10.6 7.4 0.36 10.0 7.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 NM_032117.3_3 - 0.28 10.8 9.0 0.47 10.1 9.0 1.3 1 0 0 1 1 1 0 IncA protein LPP PF04728.11 NM_032117.3_3 - 0.52 10.6 4.8 0.33 11.2 0.6 2.4 2 0 0 2 2 2 0 Lipoprotein leucine-zipper TBCA PF02970.14 NM_032117.3_3 - 0.8 9.9 7.5 0.11 12.7 2.4 2.1 2 0 0 2 2 2 0 Tubulin binding cofactor A Spc7 PF08317.9 NM_032117.3_3 - 1.6 7.4 16.4 0.24 10.1 11.4 2.0 2 1 0 2 2 2 0 Spc7 kinetochore protein Cortex-I_coil PF09304.8 NM_032117.3_3 - 6.3 6.9 11.6 2.3 8.4 6.4 2.2 2 0 0 2 2 2 0 Cortexillin I, coiled coil MHC_I PF00129.16 NM_001194999.1_3 - 2.2e-29 102.2 3.4 1.7e-23 82.9 0.1 2.3 1 1 1 2 2 2 2 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_001194999.1_3 - 3.3e-13 49.8 0.0 6.1e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain RNase_PH PF01138.19 NM_019037.2_3 - 1.2e-33 116.3 0.0 2e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 NM_019037.2_3 - 4.6e-08 32.9 0.0 7.7e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Pkinase_Tyr PF07714.15 NM_001289937.1_1 - 3.8e-86 288.5 0.0 5.3e-86 288.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 NM_001289937.1_1 - 2.3e-54 182.2 0.0 2.3e-32 111.3 0.0 2.3 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 NM_001289937.1_1 - 3.7e-44 149.6 75.0 3.6e-41 139.9 26.2 3.7 2 1 1 3 3 3 2 Growth factor receptor domain IV Pkinase PF00069.23 NM_001289937.1_1 - 1.1e-36 126.4 0.0 1.6e-36 125.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 NM_001289937.1_1 - 2e-28 99.0 82.6 6e-25 87.7 37.5 4.0 2 1 0 2 2 2 2 Furin-like cysteine rich region APH PF01636.21 NM_001289937.1_1 - 0.015 15.1 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SAP130_C PF16014.3 NM_024545.3_1 - 1.9e-200 666.3 16.6 3e-198 659.0 9.9 5.2 2 2 3 5 5 5 2 Histone deacetylase complex subunit SAP130 C-terminus DNA_pol3_delta PF06144.11 NM_024545.3_1 - 0.088 12.4 1.5 0.14 11.8 1.5 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit ECH_2 PF16113.3 NM_198047.2_1 - 8.1e-05 22.1 0.0 0.00011 21.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 NM_198047.2_2 - 5.7e-118 394.1 0.0 7.7e-118 393.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.18 NM_198047.2_2 - 3.1e-30 105.2 0.0 1.9e-29 102.6 0.0 1.9 1 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase CD20 PF04103.13 NM_139249.2_3 - 4.4e-10 39.7 0.7 6.5e-10 39.2 0.7 1.2 1 0 0 1 1 1 1 CD20-like family DUF2028 PF09667.8 NM_001276286.1_1 - 3.8e-51 173.7 3.4 6.2e-51 173.0 3.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2028) HMG_box PF00505.17 NM_001276286.1_1 - 1.7e-16 60.2 0.6 3.9e-16 59.1 0.6 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_001276286.1_1 - 1.5e-10 41.3 1.8 4.4e-10 39.9 0.8 2.2 2 0 0 2 2 2 1 HMG-box domain NAGLU PF05089.10 NM_000263.3_2 - 3.6e-147 489.5 0.9 5.4e-147 489.0 0.9 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.5 NM_000263.3_2 - 4e-81 272.3 0.1 5.5e-81 271.8 0.1 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.5 NM_000263.3_2 - 2.1e-21 75.3 0.0 4.1e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Seipin PF06775.12 NM_032667.6_3 - 9.8e-59 198.6 0.9 1.4e-58 198.2 0.9 1.2 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) ITI_HC_C PF06668.10 NM_002217.3_1 - 1.1e-68 230.5 0.4 1.9e-68 229.7 0.4 1.4 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.8 NM_002217.3_1 - 3.9e-33 113.9 3.8 7.9e-33 112.9 3.8 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.26 NM_002217.3_1 - 4.6e-25 88.7 0.0 7.5e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 NM_002217.3_1 - 5.8e-14 52.1 0.0 9.7e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 NM_002217.3_1 - 2.7e-13 50.4 0.1 6.3e-13 49.2 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.7 NM_002217.3_1 - 0.00027 21.0 0.0 0.00046 20.2 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus Glyco_hydro_61 PF03443.12 NM_002217.3_1 - 0.00095 19.0 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF2201 PF09967.7 NM_002217.3_1 - 0.079 13.0 0.0 0.47 10.5 0.0 2.3 2 0 0 2 2 2 0 VWA-like domain (DUF2201) Pkinase PF00069.23 NM_001323375.1_3 - 2e-76 256.7 0.0 2.7e-76 256.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001323375.1_3 - 3.9e-28 98.3 0.0 5.7e-28 97.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001323375.1_3 - 0.0005 19.3 0.0 0.001 18.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.4 NM_001323375.1_3 - 0.032 13.7 0.0 7 6.1 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 NM_001323375.1_3 - 0.082 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC_membrane PF00664.21 NM_004996.3_2 - 7.3e-102 340.5 28.4 1.6e-55 188.6 4.8 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 NM_004996.3_2 - 1.5e-52 177.6 0.0 1.5e-28 99.9 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 NM_004996.3_2 - 3.8e-09 36.2 0.0 0.00017 21.0 0.0 3.6 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.21 NM_004996.3_2 - 2.9e-05 24.0 0.5 0.19 11.7 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.4 NM_004996.3_2 - 3.2e-05 24.2 0.2 0.039 14.2 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain PHO4 PF01384.18 NM_004996.3_2 - 5.2e-05 22.3 0.0 0.00087 18.3 0.0 2.8 2 1 0 2 2 2 1 Phosphate transporter family DUF258 PF03193.14 NM_004996.3_2 - 0.00029 20.7 0.1 0.082 12.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_21 PF13304.4 NM_004996.3_2 - 0.00044 20.0 0.3 3.2 7.3 0.0 3.6 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.4 NM_004996.3_2 - 0.00082 18.9 0.5 0.026 14.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.4 NM_004996.3_2 - 0.0011 19.1 0.7 0.69 10.0 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.4 NM_004996.3_2 - 0.0012 18.4 1.0 0.41 10.3 0.0 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_ATPase PF09818.7 NM_004996.3_2 - 0.0078 14.9 0.2 0.32 9.6 0.0 2.6 3 0 0 3 3 3 1 Predicted ATPase of the ABC class Zeta_toxin PF06414.10 NM_004996.3_2 - 0.012 14.7 1.3 0.041 13.0 0.1 2.1 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.15 NM_004996.3_2 - 0.12 12.3 2.2 5.7 6.8 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 Dynamin_N PF00350.21 NM_004996.3_2 - 0.15 12.0 3.0 0.33 10.8 0.2 2.4 2 0 0 2 2 2 0 Dynamin family Roc PF08477.11 NM_004996.3_2 - 0.2 11.7 0.5 38 4.4 0.0 3.0 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.4 NM_004996.3_2 - 0.25 11.7 3.5 12 6.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain DSPc PF00782.18 NM_001018041.1_1 - 1.8e-13 50.3 0.0 3.2e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CBM_20 PF00686.17 NM_001018041.1_1 - 3e-07 30.1 0.0 9.3e-07 28.5 0.0 1.7 1 1 0 1 1 1 1 Starch binding domain Chibby PF14645.4 NM_001164444.1_3 - 1.4e-34 118.8 0.1 2.1e-34 118.2 0.1 1.2 1 0 0 1 1 1 1 Chibby family FERM_C PF09380.8 NM_001282984.1_3 - 7.3e-25 87.1 0.1 1.2e-24 86.4 0.1 1.3 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_001282984.1_3 - 6.6e-17 61.1 0.1 1.7e-16 59.8 0.0 1.7 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.16 NM_001282984.1_3 - 1.2e-16 61.0 0.6 2.2e-16 60.2 0.6 1.4 1 0 0 1 1 1 1 FERM central domain FA PF08736.9 NM_001282984.1_3 - 1e-15 57.4 5.2 3e-15 55.9 5.2 1.8 1 0 0 1 1 1 1 FERM adjacent (FA) RhoGEF PF00621.18 NM_001282984.1_3 - 2.8e-15 56.9 0.0 7.7e-15 55.5 0.0 1.7 2 0 0 2 2 2 1 RhoGEF domain ERM PF00769.17 NM_001009959.2_1 - 9.7e-05 22.2 0.4 9.7e-05 22.2 0.4 2.1 1 1 1 2 2 2 1 Ezrin/radixin/moesin family GnRH PF00446.15 NM_001083111.1_2 - 0.00038 20.5 3.2 0.00038 20.5 3.2 1.9 2 0 0 2 2 2 1 Gonadotropin-releasing hormone DUF3585 PF12130.6 NM_015252.3_3 - 4.6e-41 140.0 24.2 4.6e-41 140.0 24.2 3.9 3 1 0 3 3 3 1 Protein of unknown function (DUF3585) NT-C2 PF10358.7 NM_015252.3_3 - 2e-25 89.1 0.2 3.9e-25 88.2 0.2 1.5 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins CH PF00307.29 NM_015252.3_3 - 3e-22 78.7 0.0 9e-22 77.2 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_015252.3_3 - 0.0001 21.9 0.1 0.0005 19.7 0.0 2.1 2 0 0 2 2 2 1 CAMSAP CH domain DUF4287 PF14117.4 NM_015252.3_3 - 0.18 11.8 0.1 0.52 10.3 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4287) 7tm_4 PF13853.4 NM_007160.3_1 - 3.8e-47 161.2 6.5 4.9e-47 160.8 6.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_007160.3_1 - 1.3e-25 90.1 12.5 2e-25 89.4 12.5 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 NM_007160.3_1 - 3.4e-05 23.2 12.7 7.2e-05 22.1 12.7 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 NM_007160.3_1 - 0.00094 18.5 12.3 0.0022 17.3 12.3 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 NM_007160.3_1 - 0.0032 16.9 4.7 0.0059 16.0 4.7 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc DUF872 PF05915.10 NM_007160.3_1 - 0.0072 16.4 1.2 2.9 8.0 0.1 2.4 2 0 0 2 2 2 2 Eukaryotic protein of unknown function (DUF872) 7TM_GPCR_Srx PF10328.7 NM_007160.3_1 - 0.36 10.0 9.9 0.91 8.7 9.9 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Radical_SAM PF04055.19 NM_001278169.1_3 - 7.5e-31 107.6 0.0 1.6e-30 106.6 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.18 NM_001278169.1_3 - 2e-30 104.6 0.0 4.2e-30 103.5 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.18 NM_001278169.1_3 - 2.4e-12 46.5 0.0 4.6e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 TRAM domain PDEase_I PF00233.17 NM_001191056.3_2 - 9.4e-81 270.9 4.3 1.4e-80 270.3 4.3 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.10 NM_001191056.3_2 - 8.1e-31 105.5 0.1 1.6e-30 104.6 0.1 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal RHD_DNA_bind PF00554.20 NM_001243985.1_3 - 2.5e-69 232.4 0.0 3.4e-69 232.0 0.0 1.2 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 NM_001243985.1_3 - 4.1e-37 126.2 0.0 7.4e-37 125.4 0.0 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain C2 PF00168.28 NM_001297774.1_2 - 1.5e-50 169.6 0.0 1.9e-24 85.7 0.0 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.4 NM_001297774.1_2 - 0.0026 17.2 0.0 0.14 11.6 0.0 2.2 2 0 0 2 2 2 2 CEP76 C2 domain DOCK-C2 PF14429.4 NM_001297774.1_2 - 0.029 14.1 0.0 4.5 6.9 0.0 2.1 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins AA_permease PF00324.19 NM_001126107.1_3 - 1.1e-138 462.7 35.7 1.3e-138 462.4 35.7 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.13 NM_001126107.1_3 - 1.7e-135 452.1 0.0 2.3e-82 277.1 0.0 2.1 1 1 1 2 2 2 2 Solute carrier family 12 AA_permease_N PF08403.8 NM_001126107.1_3 - 1.8e-27 94.5 0.3 3.8e-27 93.4 0.3 1.6 1 0 0 1 1 1 1 Amino acid permease N-terminal DDDD PF10161.7 NM_001126107.1_3 - 1.7 8.3 3.9 8.7 6.0 0.0 3.7 4 0 0 4 4 4 0 Putative mitochondrial precursor protein PET PF06297.12 NM_001144881.1_3 - 8.1e-38 128.5 0.7 1.5e-37 127.6 0.7 1.5 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 NM_001144881.1_3 - 2.4e-24 85.2 38.9 3.9e-09 36.5 3.0 3.9 3 0 0 3 3 3 3 LIM domain Vasculin PF15337.4 NM_001144881.1_3 - 0.0078 16.9 0.4 0.045 14.5 0.0 2.4 2 0 0 2 2 2 1 Vascular protein family Vasculin-like 1 7tm_4 PF13853.4 NM_001004688.1_1 - 1e-50 173.0 18.6 1.4e-50 172.5 18.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004688.1_1 - 1.9e-19 69.8 24.0 8.4e-19 67.7 24.0 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001004688.1_1 - 6.6e-07 28.8 24.2 1.4e-06 27.7 24.2 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx OCIA PF07051.9 NM_001286773.1_2 - 1.1e-22 79.7 0.0 1.9e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) G-alpha PF00503.18 NM_182978.3_1 - 1.5e-104 349.8 0.9 1.9e-104 349.5 0.9 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 NM_182978.3_1 - 1.5e-13 50.4 2.0 1.2e-10 41.0 0.3 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_182978.3_1 - 0.018 14.3 1.6 0.13 11.4 0.1 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Roc PF08477.11 NM_182978.3_1 - 0.043 13.9 0.5 9.1 6.4 0.1 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.9 NM_182978.3_1 - 0.1 11.7 0.1 0.16 11.0 0.1 1.2 1 0 0 1 1 1 0 Bacterial TniB protein GTP_EFTU PF00009.25 NM_182978.3_1 - 0.1 12.0 0.0 7.6 5.9 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain BEX PF04538.10 NM_182978.3_1 - 1.7 9.2 6.5 0.49 10.9 3.4 1.6 2 0 0 2 2 2 0 Brain expressed X-linked like family GCIP PF13324.4 NM_001301746.1_3 - 1.1e-07 31.6 0.2 1.5e-07 31.2 0.2 1.1 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting FAM163 PF15069.4 NM_001301746.1_3 - 0.12 12.7 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 FAM163 family T-box PF00907.20 NM_001077653.2_1 - 6.8e-82 274.0 0.0 8.9e-82 273.6 0.0 1.1 1 0 0 1 1 1 1 T-box RINGv PF12906.5 NM_016496.4_1 - 1.3e-13 50.7 10.6 1.3e-13 50.7 10.6 2.8 3 0 0 3 3 3 1 RING-variant domain Vpu PF00558.17 NM_016496.4_1 - 0.008 15.8 0.1 0.008 15.8 0.1 1.6 2 0 0 2 2 2 1 Vpu protein zf-ANAPC11 PF12861.5 NM_016496.4_1 - 2.3 8.2 13.2 0.12 12.3 2.3 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.4 NM_016496.4_1 - 5.5 7.2 17.5 0.19 11.9 9.9 2.5 2 0 0 2 2 2 0 Ring finger domain Steroid_dh PF02544.14 NM_024592.4_3 - 7.6e-21 74.5 7.8 1.4e-20 73.7 7.8 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Lipocalin PF00061.21 NM_006744.3_1 - 5.6e-22 78.4 0.0 7.4e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 NM_006744.3_1 - 7.8e-06 25.8 0.0 1.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.11 NM_006744.3_1 - 0.051 13.3 0.5 0.25 11.1 0.5 1.9 1 1 0 1 1 1 0 Triabin zf-CCCH PF00642.22 NM_198581.2_2 - 1.3e-10 40.8 24.4 5.1e-05 22.9 1.6 3.9 2 1 1 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 NM_198581.2_2 - 0.015 15.4 18.6 0.015 15.4 8.2 2.7 1 1 1 2 2 2 0 Zinc-finger containing family Adaptin_binding PF10199.7 NM_198581.2_2 - 4 7.9 16.7 0.66 10.5 8.9 2.5 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 WBP-1 PF11669.6 NM_001174101.1_1 - 1.5e-05 25.4 7.8 7.3e-05 23.2 0.0 3.0 3 0 0 3 3 3 1 WW domain-binding protein 1 TMEM171 PF15471.4 NM_001174101.1_1 - 0.13 11.1 4.9 1.9 7.3 0.0 2.5 2 1 1 3 3 3 0 Transmembrane protein family 171 HemY_N PF07219.11 NM_001174101.1_1 - 0.22 11.6 0.6 0.49 10.5 0.6 1.5 1 0 0 1 1 1 0 HemY protein N-terminus TMEM52 PF14979.4 NM_001174101.1_1 - 7.4 6.3 6.0 4 7.2 0.6 2.6 2 0 0 2 2 2 0 Transmembrane 52 Pax2_C PF12403.6 NM_001280556.1_1 - 8.2e-50 167.5 14.4 8.2e-50 167.5 14.4 2.1 2 0 0 2 2 2 1 Paired-box protein 2 C terminal PAX PF00292.16 NM_001280556.1_1 - 8.9e-36 122.4 0.2 1.4e-35 121.8 0.2 1.3 1 0 0 1 1 1 1 'Paired box' domain TAS2R PF05296.11 NM_018980.2_2 - 4.1e-94 315.0 20.7 4.7e-94 314.8 20.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Galanin PF01296.16 NM_033106.3_2 - 1.1e-06 28.4 1.9 1.9e-06 27.6 1.9 1.4 1 0 0 1 1 1 1 Galanin DUF4604 PF15377.4 NM_183420.1_1 - 0.14 12.4 16.2 0.22 11.8 16.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) OAD_gamma PF04277.11 NM_183420.1_2 - 1.5 9.4 10.6 2.8 8.5 10.6 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF4604 PF15377.4 NM_183420.1_2 - 3.1 8.1 18.8 4.4 7.6 18.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) F-box PF00646.31 NM_183420.1_3 - 0.018 14.8 0.0 0.054 13.3 0.0 1.9 1 0 0 1 1 1 0 F-box domain BAT2_N PF07001.9 NM_015172.3_3 - 6.3e-50 170.2 12.1 6.3e-50 170.2 12.1 11.9 12 3 0 13 13 13 1 BAT2 N-terminus NAM-associated PF14303.4 NM_015172.3_3 - 0.07 13.7 0.0 0.07 13.7 0.0 9.5 7 3 4 11 11 11 0 No apical meristem-associated C-terminal domain Ig_2 PF13895.4 NM_001282349.1_1 - 9.9e-15 54.5 0.0 2.2e-09 37.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001282349.1_1 - 8.4e-05 23.0 0.0 0.0033 17.9 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 NM_001282349.1_1 - 0.0023 18.0 0.0 1.7 8.7 0.0 3.1 2 1 0 2 2 2 2 Immunoglobulin domain DEAD PF00270.27 NM_001257174.1_2 - 4e-29 101.5 0.0 6.5e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001257174.1_2 - 1.3e-26 93.0 0.0 3.2e-26 91.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_001257174.1_2 - 9.9e-05 22.3 0.0 0.00018 21.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CH PF00307.29 NM_001033553.2_1 - 3.5e-21 75.3 0.0 1.2e-20 73.6 0.0 2.0 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_001033553.2_1 - 1.1e-05 25.0 0.1 3.3e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 CAMSAP CH domain Fez1 PF06818.13 NM_001033553.2_1 - 0.0013 19.1 2.2 0.0013 19.1 2.2 5.2 3 1 2 5 5 5 1 Fez1 Cytochrom_C_2 PF01322.18 NM_001033553.2_1 - 5.7 7.7 14.4 0.7 10.7 2.3 3.4 3 1 0 3 3 3 0 Cytochrome C' Ebp2 PF05890.10 NM_001159936.1_3 - 2.1e-85 286.4 17.6 2.6e-85 286.1 17.6 1.1 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 Sec39 PF08314.9 NM_001159936.1_3 - 0.0069 14.7 0.2 0.0088 14.4 0.2 1.1 1 0 0 1 1 1 1 Secretory pathway protein Sec39 UPF0122 PF04297.12 NM_001159936.1_3 - 0.17 12.0 3.8 0.32 11.1 3.8 1.3 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like Noelin-1 PF12308.6 NM_001159936.1_3 - 1.6 8.6 5.5 11 6.0 0.7 2.3 1 1 1 2 2 2 0 Neurogenesis glycoprotein CD225 PF04505.10 NM_001025295.2_1 - 8.1e-26 89.8 0.0 1.6e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF3708 PF12501.6 NM_001025295.2_1 - 0.068 12.8 0.3 0.1 12.3 0.3 1.2 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter fn3 PF00041.19 NM_001319233.1_2 - 3.8e-24 84.7 7.0 1.7e-07 31.3 0.1 5.5 5 1 0 5 5 5 4 Fibronectin type III domain Lep_receptor_Ig PF06328.9 NM_001319233.1_2 - 4.8e-11 42.4 0.2 1.2e-10 41.2 0.2 1.7 1 0 0 1 1 1 1 Ig-like C2-type domain IL6Ra-bind PF09240.8 NM_001319233.1_2 - 0.00032 20.9 0.1 0.0012 19.1 0.1 2.1 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Tissue_fac PF01108.15 NM_001319233.1_2 - 0.00063 19.4 0.4 0.92 9.2 0.0 2.6 2 0 0 2 2 2 2 Tissue factor Pur_ac_phosph_N PF16656.3 NM_001319233.1_2 - 0.036 14.5 0.2 4.4 7.8 0.0 3.0 3 0 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain Pkinase PF00069.23 NM_004612.3_1 - 5.9e-35 120.8 0.0 8.6e-35 120.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_004612.3_1 - 1.4e-33 116.2 0.0 1.9e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.10 NM_004612.3_1 - 1.2e-16 59.7 0.4 2.8e-16 58.6 0.4 1.6 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 NM_004612.3_1 - 2.8e-09 37.8 11.1 6.8e-09 36.5 11.1 1.7 1 0 0 1 1 1 1 Activin types I and II receptor domain APH PF01636.21 NM_004612.3_1 - 0.15 11.8 0.1 0.15 11.8 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family NYAP_N PF15439.4 NM_020864.1_2 - 8.6e-143 476.2 30.2 8.6e-143 476.2 30.2 2.9 2 1 0 2 2 2 1 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter NYAP_C PF15452.4 NM_020864.1_2 - 9.7e-45 153.3 13.3 9.7e-45 153.3 13.3 1.6 2 0 0 2 2 2 1 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter DUF4591 PF15261.4 NM_020864.1_2 - 4.4 7.9 11.1 0.12 12.9 4.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4591) RabGAP-TBC PF00566.16 NM_144572.1_1 - 2.7e-57 193.8 2.0 2.7e-57 193.8 2.0 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain PH PF00169.27 NM_144572.1_1 - 1.6e-06 28.5 0.0 3.3e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 PH domain KRAB PF01352.25 NM_144572.1_1 - 0.0053 16.3 0.2 0.017 14.6 0.2 1.8 1 0 0 1 1 1 1 KRAB box DUF4795 PF16043.3 NM_144572.1_1 - 0.0054 16.2 7.0 0.0098 15.4 7.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) HIP1_clath_bdg PF16515.3 NM_144572.1_1 - 0.0057 17.1 3.7 0.0057 17.1 3.7 3.3 3 0 0 3 3 3 1 Clathrin-binding domain of Huntingtin-interacting protein 1 PH_8 PF15409.4 NM_144572.1_1 - 0.059 13.5 0.0 0.17 12.1 0.0 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain DUF1664 PF07889.10 NM_144572.1_1 - 0.27 11.1 9.4 4.1 7.3 0.5 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Spc29 PF17082.3 NM_144572.1_1 - 0.43 10.3 5.7 4.1 7.0 0.3 2.3 2 0 0 2 2 2 0 Spindle Pole Component 29 AAA_13 PF13166.4 NM_144572.1_1 - 1.7 7.1 6.8 7.9 4.9 6.8 1.8 1 1 0 1 1 1 0 AAA domain IncA PF04156.12 NM_144572.1_1 - 2.9 7.5 21.9 0.3 10.7 9.9 2.5 2 0 0 2 2 2 0 IncA protein HALZ PF02183.16 NM_144572.1_1 - 5.1 7.3 9.8 1.4 9.1 1.4 3.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper Mnd1 PF03962.13 NM_144572.1_1 - 5.5 6.7 13.5 10 5.8 4.8 2.4 2 0 0 2 2 2 0 Mnd1 family zf-C2H2_4 PF13894.4 NM_001042539.2_1 - 3.8e-24 83.1 53.9 0.00033 21.1 3.4 8.5 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001042539.2_1 - 1e-23 82.3 56.7 1.1e-05 25.5 3.7 8.6 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001042539.2_1 - 6.9e-16 57.8 61.7 1.4e-05 25.1 2.8 9.0 10 0 0 10 10 8 4 Zinc-finger double domain zf-C2H2_jaz PF12171.6 NM_001042539.2_1 - 2.6e-08 33.8 34.5 0.051 13.8 0.1 7.7 8 0 0 8 8 8 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001042539.2_1 - 9.3e-07 28.9 43.2 0.018 15.3 1.1 7.8 8 0 0 8 8 8 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 NM_001042539.2_1 - 1.2e-05 25.0 45.8 0.0016 18.2 2.1 8.0 8 1 0 8 8 8 3 C2H2-type zinc finger XPA_N PF01286.16 NM_001042539.2_1 - 0.023 14.6 14.8 11 6.0 0.0 6.5 7 0 0 7 7 7 0 XPA protein N-terminal GAGA PF09237.9 NM_001042539.2_1 - 0.17 11.6 8.8 1.3 8.8 0.0 3.8 4 0 0 4 4 4 0 GAGA factor Zn-ribbon_8 PF09723.8 NM_001042539.2_1 - 0.18 11.8 26.8 0.034 14.1 1.8 5.0 4 1 1 5 5 5 0 Zinc ribbon domain DZR PF12773.5 NM_001042539.2_1 - 1.4 8.8 25.9 0.08 12.8 0.9 4.4 4 1 1 5 5 5 0 Double zinc ribbon Cript PF10235.7 NM_001042539.2_1 - 2 8.9 17.9 2.3 8.7 0.6 4.2 2 1 2 4 4 4 0 Microtubule-associated protein CRIPT zf-C2H2_8 PF15909.3 NM_001042539.2_1 - 2 8.6 15.0 0.31 11.2 5.2 2.9 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_2 PF12756.5 NM_001042539.2_1 - 2.1 8.6 35.3 9.2 6.5 0.9 7.0 2 1 3 6 6 6 0 C2H2 type zinc-finger (2 copies) DUF2225 PF09986.7 NM_001042539.2_1 - 2.3 7.7 5.8 3.5 7.1 4.4 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) C1_4 PF07975.10 NM_001042539.2_1 - 3 8.0 15.3 2.1 8.6 0.9 4.2 4 0 0 4 4 4 0 TFIIH C1-like domain OSTMP1 PF09777.7 NM_001042539.2_1 - 7.7 5.7 11.0 2.6 7.2 7.6 1.8 2 1 0 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor FYVE PF01363.19 NM_001042539.2_1 - 9.4 6.3 34.0 0.95 9.5 7.8 4.8 3 1 2 5 5 5 0 FYVE zinc finger EF-hand_7 PF13499.4 NM_001284267.1_1 - 5.6e-15 55.4 0.2 3.8e-09 36.7 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_001284267.1_1 - 2e-13 49.0 0.6 0.0093 15.7 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.30 NM_001284267.1_1 - 3.7e-12 44.7 0.8 0.00049 19.3 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 NM_001284267.1_1 - 4.6e-11 42.2 0.6 0.00024 20.7 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 NM_001284267.1_1 - 1.2e-05 24.4 0.0 0.09 12.2 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.4 NM_001284267.1_1 - 0.0013 18.9 0.0 1.2 9.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EST1_DNA_bind PF10373.7 NM_001323617.1_1 - 1.6e-39 136.0 3.8 1.4e-32 113.2 1.2 2.3 2 0 0 2 2 2 2 Est1 DNA/RNA binding domain EST1 PF10374.7 NM_001323617.1_1 - 4.1e-24 85.6 1.5 4.1e-24 85.6 1.5 2.3 2 1 0 2 2 2 1 Telomerase activating protein Est1 PIN_4 PF13638.4 NM_001323617.1_1 - 4.2e-06 27.0 0.0 9.9e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 PIN domain MAP17 PF15807.3 NM_005764.3_3 - 1.4e-34 118.9 0.0 2.1e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Phage_holin_3_6 PF07332.9 NM_005764.3_3 - 0.042 13.7 1.9 0.065 13.2 1.9 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III RIG-I_C-RD PF11648.6 NM_024119.2_2 - 5.9e-37 126.4 0.0 1.2e-36 125.4 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of RIG-I Helicase_C PF00271.29 NM_024119.2_2 - 5.8e-20 71.6 1.5 1.1e-18 67.5 0.3 3.0 3 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_024119.2_2 - 1.3e-18 67.4 0.0 3.7e-18 66.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.27 NM_024119.2_2 - 5.9e-16 58.6 1.7 6.9e-15 55.1 0.0 2.9 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_19 PF13245.4 NM_024119.2_2 - 0.00012 22.3 0.4 0.29 11.3 0.0 3.2 2 1 1 3 3 3 2 AAA domain Folliculin PF11704.6 NM_024119.2_2 - 1.5 8.6 4.2 1.4 8.6 2.6 1.7 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Wtap PF17098.3 NM_001270532.1_3 - 9.5e-28 97.0 3.2 1.7e-27 96.1 3.2 1.4 1 0 0 1 1 1 1 WTAP/Mum2p family PRY PF13765.4 NM_001017922.1_1 - 2.7e-22 78.0 0.2 5.5e-22 77.0 0.2 1.6 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 NM_001017922.1_1 - 3.3e-16 59.4 0.1 5.7e-16 58.6 0.1 1.3 1 0 0 1 1 1 1 SPRY domain V-set PF07686.15 NM_001017922.1_1 - 8.9e-10 38.6 0.0 2.2e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 NM_001017922.1_1 - 0.0016 18.4 0.0 0.0051 16.8 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_001017922.1_1 - 0.0018 18.7 0.0 0.0046 17.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_001017922.1_1 - 0.0033 17.3 0.0 0.0071 16.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Izumo-Ig PF16706.3 NM_001017922.1_1 - 0.063 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain IncA PF04156.12 NM_001017922.1_1 - 0.075 12.7 0.4 0.11 12.1 0.4 1.2 1 0 0 1 1 1 0 IncA protein DUF4381 PF14316.4 NM_001017922.1_1 - 0.17 12.0 0.7 0.31 11.1 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) SKG6 PF08693.8 NM_001017922.1_1 - 0.46 9.8 2.1 0.87 8.9 2.1 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TAS2R PF05296.11 NM_016944.1_1 - 8.9e-96 320.4 33.2 1e-95 320.3 33.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Pro_isomerase PF00160.19 NM_001297644.1_2 - 1.8e-44 151.7 0.0 3.1e-44 150.9 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-RING_2 PF13639.4 NM_001134337.2_1 - 6.5e-11 42.2 8.8 6.5e-11 42.2 8.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.3 NM_001134337.2_1 - 3.3e-08 33.0 4.9 8.8e-08 31.6 4.9 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.5 NM_001134337.2_1 - 1e-07 32.0 6.7 2.6e-07 30.7 6.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 NM_001134337.2_1 - 2.4e-07 30.4 9.0 8.2e-07 28.6 9.0 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001134337.2_1 - 2.1e-06 27.4 8.0 5.8e-06 25.9 8.0 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001134337.2_1 - 3.7e-05 23.5 6.3 0.00012 21.8 6.3 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 NM_001134337.2_1 - 0.00043 19.9 7.0 0.00043 19.9 7.0 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001134337.2_1 - 0.00079 19.3 8.4 0.00084 19.2 6.4 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 NM_001134337.2_1 - 0.002 18.0 1.4 0.002 18.0 1.4 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.4 NM_001134337.2_1 - 0.2 11.5 7.1 0.048 13.5 3.5 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 RINGv PF12906.5 NM_001134337.2_1 - 2.6 8.1 8.1 10 6.2 8.1 2.1 1 0 0 1 1 1 0 RING-variant domain La PF05383.15 NM_001170803.1_2 - 1.3e-16 60.2 0.1 2.4e-16 59.4 0.1 1.4 1 0 0 1 1 1 1 La domain GCFC PF07842.10 NM_013329.3_2 - 9.9e-29 100.7 0.3 2.4e-28 99.4 0.3 1.6 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein zf-A20 PF01754.14 NM_001242914.1_2 - 2.8e-12 46.2 8.8 8.5e-12 44.7 8.8 1.9 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.14 NM_001242914.1_2 - 6.4e-09 35.7 7.7 6.4e-09 35.7 7.7 2.6 2 0 0 2 2 2 1 AN1-like Zinc finger S_100 PF01023.17 NM_007113.3_3 - 4.4e-11 42.2 0.0 1.2e-10 40.8 0.0 1.9 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 NM_007113.3_3 - 0.013 14.9 0.4 0.027 13.9 0.4 1.6 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.4 NM_007113.3_3 - 0.024 14.4 0.6 1.7 8.6 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_8 PF13833.4 NM_007113.3_3 - 0.033 13.8 0.1 0.057 13.1 0.1 1.4 1 0 0 1 1 1 0 EF-hand domain pair T-box_assoc PF16176.3 NM_005442.3_2 - 3.2e-102 341.2 1.6 5.8e-102 340.4 1.6 1.4 1 0 0 1 1 1 1 T-box transcription factor-associated T-box PF00907.20 NM_005442.3_2 - 3e-75 252.4 1.1 4.4e-75 251.8 1.1 1.2 1 0 0 1 1 1 1 T-box DUF543 PF04418.10 NM_001032363.3_1 - 1.2e-22 79.6 0.4 2.3e-22 78.6 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Ada3 PF10198.7 NM_001278270.1_2 - 5.2e-27 94.4 11.0 1.2e-25 90.1 11.1 2.5 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 YkyA PF10368.7 NM_001278270.1_2 - 1.9 8.1 7.9 8.2 6.0 6.0 2.3 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Pkinase PF00069.23 NM_013233.2_2 - 2.2e-62 210.7 0.0 2.8e-62 210.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_013233.2_2 - 6.1e-46 156.7 0.0 8.7e-46 156.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.6 NM_013233.2_2 - 2.4e-13 49.6 0.0 4.9e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C terminal Kinase-like PF14531.4 NM_013233.2_2 - 0.0011 18.2 0.0 0.0017 17.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 NM_013233.2_2 - 0.11 12.3 0.1 0.5 10.1 0.1 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 NM_013233.2_2 - 0.12 11.6 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Acetyltransf_1 PF00583.23 NM_181528.3_3 - 6.5e-09 35.9 0.0 1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 NM_181528.3_3 - 2.6e-05 24.4 0.0 5.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 NM_181528.3_3 - 5.7e-05 22.9 0.0 9.7e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 NM_181528.3_3 - 0.032 14.1 0.0 0.064 13.1 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein SGIII PF15467.4 NM_001165257.1_3 - 9.7e-199 661.1 32.4 1.4e-198 660.6 32.4 1.1 1 0 0 1 1 1 1 Secretogranin-3 DUF2680 PF10925.6 NM_001165257.1_3 - 2.6e-06 27.2 2.6 0.9 9.5 0.1 3.7 3 0 0 3 3 3 3 Protein of unknown function (DUF2680) DUF1725 PF08333.9 NM_001242815.1_3 - 1.3e-08 34.1 0.4 2.7e-08 33.1 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DUF2457 PF10446.7 NM_001199635.1_1 - 2.5 7.0 5.0 3.6 6.5 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) 7tm_2 PF00002.22 NM_001199635.1_2 - 4.5e-93 310.9 18.0 6.6e-93 310.4 18.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_001199635.1_2 - 5.4e-27 93.7 1.3 2.1e-26 91.8 1.3 2.1 1 0 0 1 1 1 1 Hormone receptor domain CIDE-N PF02017.13 NM_022094.3_3 - 3.5e-27 94.1 0.1 5.5e-27 93.5 0.1 1.3 1 0 0 1 1 1 1 CIDE-N domain MTP18 PF10558.7 NM_016498.4_3 - 3.2e-17 62.9 1.8 1.3e-16 60.9 1.8 1.8 1 1 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) HMG14_17 PF01101.16 NM_004965.6_1 - 4.3e-32 110.8 27.5 4.3e-32 110.8 27.5 1.6 2 0 0 2 2 2 1 HMG14 and HMG17 ELO PF01151.16 NM_022726.3_2 - 7.5e-66 222.1 21.9 1.1e-65 221.6 21.9 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family PAS_3 PF08447.10 NM_001164749.1_2 - 2.1e-23 82.3 0.2 2.7e-18 65.9 0.2 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 NM_001164749.1_2 - 3.2e-12 46.3 0.0 2.3e-09 37.1 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 NM_001164749.1_2 - 1.1e-11 44.7 0.0 1.2e-08 34.9 0.1 2.4 2 0 0 2 2 2 2 PAS domain PAS_9 PF13426.5 NM_001164749.1_2 - 7.5e-08 32.5 0.0 0.00014 21.9 0.1 2.5 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 NM_001164749.1_2 - 0.00075 19.3 0.6 0.002 17.9 0.6 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.8 NM_001164749.1_2 - 0.0019 18.3 0.0 3 8.0 0.0 2.3 2 0 0 2 2 2 2 PAS fold DUF4611 PF15387.4 NM_032490.4_3 - 2.4e-41 139.7 0.4 3e-41 139.4 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) VHL PF01847.14 NM_000551.3_1 - 4.9e-39 132.0 0.0 9.5e-39 131.1 0.0 1.5 1 0 0 1 1 1 1 VHL beta domain VHL_C PF17211.1 NM_000551.3_1 - 3.6e-30 103.6 2.7 8.1e-30 102.5 2.7 1.6 1 0 0 1 1 1 1 VHL box domain Trypan_PARP PF05887.9 NM_000551.3_1 - 1.2 9.0 11.8 2.2 8.2 11.8 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Toxin_18 PF08087.9 NM_000551.3_3 - 0.14 12.1 13.6 0.32 10.9 0.3 3.6 3 0 0 3 3 3 0 Conotoxin O-superfamily Arf PF00025.19 NM_001267547.2_1 - 5.4e-44 149.6 0.1 7.3e-44 149.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 NM_001267547.2_1 - 9.1e-13 48.4 0.1 1.3e-12 47.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_001267547.2_1 - 3e-12 46.3 0.0 3.9e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 NM_001267547.2_1 - 4.2e-08 32.6 0.0 0.00012 21.2 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.8 NM_001267547.2_1 - 3e-07 29.9 0.0 4.3e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.10 NM_001267547.2_1 - 4.7e-07 29.3 0.0 6.2e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 NM_001267547.2_1 - 2.7e-06 27.3 0.0 4e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RHD_dimer PF16179.3 NM_001258295.1_1 - 5.7e-25 87.2 0.4 9.6e-25 86.5 0.4 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.20 NM_001258295.1_1 - 5.6e-22 78.3 0.4 1.2e-21 77.3 0.4 1.6 1 1 0 1 1 1 1 Rel homology DNA-binding domain TIG PF01833.22 NM_001258295.1_1 - 2.1e-06 27.6 0.0 4.2e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 IPT/TIG domain Ion_trans PF00520.29 NM_001160160.1_1 - 1.2e-239 790.8 89.3 8.3e-84 280.5 9.7 5.1 4 1 1 5 5 5 5 Ion transport protein Na_trans_assoc PF06512.11 NM_001160160.1_1 - 1e-53 182.3 2.9 1e-53 182.3 2.9 2.0 2 0 0 2 2 2 1 Sodium ion transport-associated Na_trans_cytopl PF11933.6 NM_001160160.1_1 - 5.4e-50 170.1 0.4 1.1e-49 169.1 0.4 1.5 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel PKD_channel PF08016.10 NM_001160160.1_1 - 7.2e-07 28.1 80.5 7.5e-05 21.5 9.2 8.7 6 3 2 9 9 9 6 Polycystin cation channel GPHH PF16905.3 NM_001160160.1_1 - 8.6e-06 25.3 0.0 2.3e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.25 NM_001160160.1_1 - 0.03 14.0 0.3 0.096 12.4 0.3 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif UPF0239 PF06783.9 NM_001160160.1_1 - 0.73 9.9 3.6 2.5 8.2 0.1 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0239) Cytochrom_B561 PF03188.14 NM_001017916.1_1 - 2.9e-44 150.4 8.5 4.7e-44 149.7 8.5 1.3 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF4079 PF13301.4 NM_001017916.1_1 - 0.23 11.5 7.4 0.56 10.2 7.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) Pkinase PF00069.23 NM_178170.2_1 - 4.6e-65 219.5 0.0 5.9e-65 219.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RCC1 PF00415.16 NM_178170.2_1 - 6.5e-55 183.4 18.1 1.2e-12 48.1 0.1 8.1 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.15 NM_178170.2_1 - 4.8e-44 150.5 0.0 7.3e-44 149.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RCC1_2 PF13540.4 NM_178170.2_1 - 5.9e-20 70.4 24.9 1.1e-05 24.9 0.1 6.7 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat APH PF01636.21 NM_178170.2_1 - 0.12 12.1 2.0 0.61 9.8 1.5 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family HMG_box PF00505.17 NM_014587.4_2 - 9.2e-26 89.9 1.2 1.7e-25 89.1 1.2 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box Sox_N PF12444.6 NM_014587.4_2 - 2.7e-25 89.2 0.3 9.9e-25 87.3 0.3 2.1 1 0 0 1 1 1 1 Sox developmental protein N terminal HMG_box_2 PF09011.8 NM_014587.4_2 - 1.2e-10 41.6 0.6 2.6e-10 40.6 0.6 1.5 1 0 0 1 1 1 1 HMG-box domain Hormone_1 PF00103.18 NM_001317.5_1 - 3e-62 210.0 1.0 3.7e-62 209.8 1.0 1.1 1 0 0 1 1 1 1 Somatotropin hormone family zf-C2H2 PF00096.24 NM_001303461.1_2 - 5e-16 58.0 27.5 0.00013 22.1 3.0 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001303461.1_2 - 2e-15 56.3 22.4 1.2e-08 34.9 0.6 4.9 4 1 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001303461.1_2 - 1.7e-09 37.5 25.7 0.00084 19.8 1.5 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001303461.1_2 - 0.0015 18.7 9.8 0.48 10.7 0.4 3.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001303461.1_2 - 0.0026 17.6 18.5 0.075 12.9 2.5 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_001303461.1_2 - 0.07 12.8 17.0 0.33 10.6 0.2 4.7 4 1 0 4 4 4 0 C2H2-type zinc-finger domain FYVE PF01363.19 NM_001303461.1_2 - 0.16 12.0 20.0 0.99 9.5 10.0 2.8 2 1 1 3 3 3 0 FYVE zinc finger zf-met PF12874.5 NM_001303461.1_2 - 0.8 10.0 21.9 0.045 14.0 2.9 4.5 4 1 0 4 4 4 0 Zinc-finger of C2H2 type AF-4 PF05110.11 NM_001303461.1_2 - 1.3 6.9 3.7 1.8 6.4 3.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Rpr2 PF04032.14 NM_001303461.1_2 - 4.4 7.6 14.4 3.6e+02 1.4 12.0 3.1 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-C2H2_2 PF12756.5 NM_001303461.1_2 - 6.8 7.0 15.3 5.3 7.3 1.0 3.4 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.3 NM_001303461.1_2 - 7.3 7.3 11.1 4.8 7.9 1.0 2.5 1 1 1 2 2 2 0 zinc-ribbon family DUF2256 PF10013.7 NM_001303461.1_2 - 7.5 6.6 6.6 18 5.4 0.3 3.3 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) A2L_zn_ribbon PF08792.8 NM_001303461.1_2 - 8.1 6.2 8.1 1.9 8.2 0.1 3.2 3 0 0 3 3 3 0 A2L zinc ribbon domain SAC3_GANP PF03399.14 NM_013299.3_3 - 1.6e-72 244.3 0.0 1.9e-72 244.0 0.0 1.0 1 0 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.7 NM_013299.3_3 - 0.12 12.2 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family Cu-oxidase_3 PF07732.13 NM_001130860.3_3 - 1.2e-24 86.5 0.4 3.3e-07 30.2 0.0 4.9 5 0 0 5 5 5 3 Multicopper oxidase Cu-oxidase_2 PF07731.12 NM_001130860.3_3 - 1.4e-20 73.3 20.0 8.4e-15 54.6 1.7 6.4 6 1 0 6 6 6 3 Multicopper oxidase BPS PF08947.8 NM_001030002.2_1 - 6.6e-28 96.1 0.1 1.4e-27 95.1 0.1 1.6 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 NM_001030002.2_1 - 3.9e-16 58.7 0.1 6.6e-16 58.0 0.1 1.4 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 NM_001030002.2_1 - 1.5e-14 54.3 0.0 3.1e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 NM_001030002.2_1 - 5.8e-09 36.3 0.0 1.7e-08 34.8 0.0 1.8 2 0 0 2 2 2 1 PH domain SAM_1 PF00536.28 NM_001286409.1_3 - 5.1e-14 52.3 0.1 9.2e-14 51.5 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001286409.1_3 - 0.021 14.8 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_001286409.1_3 - 0.038 13.8 0.0 0.079 12.8 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain V-set PF07686.15 NM_001146172.1_1 - 2.5e-05 24.3 0.0 4.4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 NM_001146172.1_1 - 0.069 13.1 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001146172.1_1 - 0.074 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Kunitz_BPTI PF00014.21 NM_003710.3_1 - 6.9e-34 115.7 20.9 5.9e-17 61.5 8.0 3.0 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain MANEC PF07502.12 NM_003710.3_1 - 9.9e-27 92.9 1.0 9.9e-27 92.9 1.0 3.3 3 1 1 4 4 4 1 MANEC domain Ldl_recept_a PF00057.16 NM_003710.3_1 - 6.7e-09 35.7 12.5 2e-08 34.2 12.5 1.9 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Chordopox_A13L PF05961.9 NM_003710.3_1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein DUF1179 PF06678.9 NM_003710.3_2 - 4.8 7.1 7.5 4.2 7.3 5.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1179) Ras PF00071.20 NM_001039802.1_2 - 3.1e-52 176.3 0.0 4e-52 176.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001039802.1_2 - 1.3e-18 67.2 0.0 1.8e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001039802.1_2 - 4.1e-07 29.5 0.0 6.1e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PET117 PF15786.3 NM_001039802.1_2 - 0.0025 17.9 0.0 0.004 17.2 0.0 1.3 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial PDZ PF00595.22 NM_001303515.1_3 - 3e-16 59.4 0.8 2.1e-13 50.3 0.1 2.5 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001303515.1_3 - 9.1e-07 29.0 0.1 2.3e-06 27.7 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 NM_001303515.1_3 - 0.0093 15.8 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 Tricorn protease PDZ domain zf-H2C2_2 PF13465.4 NM_153695.3_2 - 1.6e-12 47.1 7.6 4.7e-06 26.7 0.2 3.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.24 NM_153695.3_2 - 7.1e-11 41.8 4.4 0.00018 21.6 0.7 3.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_153695.3_2 - 3.2e-07 30.5 3.7 0.0025 18.4 0.4 3.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_153695.3_2 - 1.6e-06 27.8 2.0 3.5e-06 26.7 0.2 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.5 NM_153695.3_2 - 0.00017 21.8 1.1 0.00059 20.0 0.3 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_153695.3_2 - 0.0072 16.5 0.1 0.0072 16.5 0.1 2.7 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding Phage_GPD PF05954.9 NM_153695.3_2 - 0.071 12.3 0.9 0.11 11.6 0.9 1.2 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) KRAB PF01352.25 NM_001320776.1_1 - 6.1e-19 67.3 1.6 1.1e-18 66.5 1.6 1.3 1 0 0 1 1 1 1 KRAB box TSP_1 PF00090.17 NM_018676.3_3 - 8.9e-10 38.5 6.4 8.9e-10 38.5 6.4 2.7 3 0 0 3 3 3 1 Thrombospondin type 1 domain 7tm_2 PF00002.22 NM_001184835.1_3 - 6.2e-57 192.6 22.8 1e-56 191.9 22.8 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 NM_001184835.1_3 - 3e-13 50.0 2.1 1.1e-12 48.2 2.1 2.1 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif TraL PF07178.9 NM_001184835.1_3 - 9.2 6.7 12.2 6.3 7.2 0.2 3.7 3 0 0 3 3 3 0 TraL protein DUF2076 PF09849.7 NM_001097640.1_2 - 0.068 13.1 2.2 0.11 12.4 2.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Glyco_transf_10 PF00852.17 NM_001097640.1_3 - 7.1e-68 227.7 0.5 9.8e-68 227.2 0.5 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 NM_001097640.1_3 - 3.4e-35 120.7 0.0 5.7e-35 120.0 0.0 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal SCAN PF02023.15 NM_145115.2_1 - 9.1e-39 131.1 2.4 1.5e-38 130.4 2.4 1.3 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 NM_145115.2_1 - 3.7e-37 125.0 50.6 5.7e-09 35.9 0.8 8.7 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 NM_145115.2_1 - 1.2e-30 104.1 65.3 9.4e-08 32.0 0.7 8.5 9 0 0 9 9 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_145115.2_1 - 3.3e-14 52.2 57.1 0.00028 21.3 0.5 8.6 8 0 0 8 8 7 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_145115.2_1 - 0.00022 21.0 44.7 0.037 13.8 0.6 7.8 7 0 0 7 7 7 4 C2H2-type zinc finger KRAB PF01352.25 NM_145115.2_1 - 0.00055 19.4 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_145115.2_1 - 0.0023 17.9 26.7 0.0043 17.0 1.3 4.8 4 1 1 5 5 5 2 Zinc ribbon domain zf-C2HC_2 PF13913.4 NM_145115.2_1 - 0.0023 17.6 13.4 0.21 11.4 0.5 4.8 4 0 0 4 4 4 2 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 NM_145115.2_1 - 0.0083 16.3 28.1 0.18 12.1 0.0 7.4 8 0 0 8 8 8 1 Zinc-finger double-stranded RNA-binding FYDLN_acid PF09538.8 NM_145115.2_1 - 0.0094 16.5 5.8 6.2 7.4 1.0 4.0 3 1 0 3 3 3 1 Protein of unknown function (FYDLN_acid) zf-Di19 PF05605.10 NM_145115.2_1 - 0.039 14.1 16.6 1.2 9.3 0.3 4.6 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.4 NM_145115.2_1 - 0.31 11.2 4.3 32 4.7 0.3 4.1 3 0 0 3 3 3 0 zinc-ribbon Tubulin PF00091.23 NM_001278552.1_2 - 6.2e-67 225.5 0.0 8.2e-67 225.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_001278552.1_2 - 5.8e-51 171.9 0.0 8.7e-51 171.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 NM_001278552.1_2 - 0.02 14.5 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain NmrA PF05368.11 NM_020677.4_2 - 4.9e-47 160.3 0.0 6.5e-47 159.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.4 NM_020677.4_2 - 2.7e-10 40.3 0.0 3.7e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.16 NM_020677.4_2 - 5.2e-05 23.3 0.1 0.00012 22.2 0.1 1.5 1 1 0 1 1 1 1 TrkA-N domain KR PF08659.8 NM_020677.4_2 - 0.0048 16.7 0.1 0.0091 15.8 0.1 1.4 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.16 NM_020677.4_2 - 0.01 16.0 0.1 0.032 14.4 0.1 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.19 NM_020677.4_2 - 0.011 15.0 0.1 0.018 14.3 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.17 NM_020677.4_2 - 0.014 14.2 0.0 0.019 13.8 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.15 NM_020677.4_2 - 0.041 14.3 0.1 0.092 13.2 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.23 NM_020677.4_2 - 0.17 11.2 0.6 0.29 10.4 0.2 1.5 2 0 0 2 2 2 0 short chain dehydrogenase p25-alpha PF05517.10 NM_007030.2_3 - 6.7e-64 214.6 1.4 9.2e-64 214.2 1.4 1.2 1 0 0 1 1 1 1 p25-alpha DUF3591 PF12157.6 NM_153809.2_1 - 2e-163 544.0 0.0 9.7e-163 541.8 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3591) Bromodomain PF00439.23 NM_153809.2_1 - 1e-40 137.6 3.8 1.8e-21 75.9 0.6 2.7 2 0 0 2 2 2 2 Bromodomain TBP-binding PF09247.9 NM_153809.2_1 - 5.4e-20 71.3 2.1 1.5e-19 69.9 2.1 1.8 1 0 0 1 1 1 1 TATA box-binding protein binding zf-CCHC_6 PF15288.4 NM_153809.2_1 - 1.5e-15 56.6 0.4 3.4e-15 55.5 0.4 1.6 1 0 0 1 1 1 1 Zinc knuckle V-set PF07686.15 NM_174934.3_3 - 2.4e-09 37.2 0.0 4.6e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_174934.3_3 - 0.00097 19.6 0.0 0.0024 18.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_174934.3_3 - 0.002 18.0 0.0 0.0037 17.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_174934.3_3 - 0.0066 16.5 0.1 0.016 15.2 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Glycophorin_A PF01102.16 NM_174934.3_3 - 0.054 13.6 0.0 0.096 12.8 0.0 1.3 1 0 0 1 1 1 0 Glycophorin A TMEM154 PF15102.4 NM_174934.3_3 - 0.15 11.8 0.1 0.24 11.2 0.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family Syndecan PF01034.18 NM_174934.3_3 - 1.5 8.6 4.4 2.9 7.7 4.4 1.3 1 0 0 1 1 1 0 Syndecan domain RNA_pol_Rbc25 PF08292.10 NM_138338.4_2 - 1.9e-41 141.2 0.0 3.2e-41 140.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.15 NM_138338.4_2 - 1.9e-19 69.7 0.2 4.1e-19 68.6 0.0 1.7 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Crystallin PF00525.16 NM_001885.2_2 - 1.3e-29 102.0 7.2 2.6e-29 101.0 7.2 1.6 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.19 NM_001885.2_2 - 1.4e-24 86.0 0.1 2e-24 85.5 0.1 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family 2OG-FeII_Oxy_2 PF13532.4 NM_001205179.1_2 - 4.4e-19 69.3 0.2 6.5e-19 68.8 0.2 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Sulfotransfer_3 PF13469.4 NM_001008566.1_3 - 2.3e-57 194.8 0.0 3.3e-57 194.2 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.25 NM_001008566.1_3 - 1.5e-06 27.8 0.0 7.4e-06 25.5 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase domain RRM_1 PF00076.20 NM_001322444.1_2 - 1.1e-12 47.4 0.1 5.3e-08 32.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAM_1 PF00536.28 NM_001220479.2_3 - 6.7e-27 93.6 0.5 4.4e-13 49.3 0.2 3.6 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001220479.2_3 - 4.8e-22 77.7 0.5 7.3e-08 32.3 0.1 3.6 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) Sugarporin_N PF11471.6 NM_001220479.2_3 - 2.2 8.2 6.3 7.6 6.5 6.3 1.9 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension PTRF_SDPR PF15237.4 NM_001220479.2_3 - 4.1 6.8 15.4 0.11 12.0 0.9 2.3 2 0 0 2 2 2 0 PTRF/SDPR family Filament PF00038.19 NM_001220479.2_3 - 7.2 6.0 26.3 0.72 9.2 18.0 2.3 2 0 0 2 2 2 0 Intermediate filament protein FlxA PF14282.4 NM_001220479.2_3 - 8.9 6.2 14.9 0.24 11.3 0.2 3.3 2 1 1 3 3 3 0 FlxA-like protein Ion_trans PF00520.29 NM_020389.2_1 - 6.7e-33 113.8 14.2 9.5e-33 113.3 14.2 1.2 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.9 NM_020389.2_1 - 1.3e-25 89.2 1.9 2.9e-25 88.1 1.9 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II PKD_channel PF08016.10 NM_020389.2_1 - 9.2e-12 44.2 12.7 2.3e-11 42.9 12.7 1.6 1 1 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.5 NM_020389.2_1 - 9.7e-10 38.8 0.2 2.8e-06 27.7 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_020389.2_1 - 3.7e-05 23.8 0.3 1.3 9.4 0.0 4.2 2 1 2 4 4 4 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_020389.2_1 - 0.0014 19.1 0.3 0.065 13.7 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_020389.2_1 - 0.0022 18.2 2.0 29 5.5 0.0 4.8 4 0 0 4 4 4 0 Ankyrin repeat Ank PF00023.28 NM_020389.2_1 - 0.03 14.7 2.4 21 5.7 0.0 3.5 2 1 1 3 3 3 0 Ankyrin repeat ING PF12998.5 NM_020389.2_1 - 0.51 10.8 7.5 2.4 8.6 3.0 3.0 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Baculo_PEP_C PF04513.10 NM_020389.2_1 - 2.6 7.9 5.2 0.6 10.0 0.4 2.4 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lig_chan PF00060.24 NM_020389.2_1 - 8 6.1 6.1 21 4.8 0.2 2.5 2 0 0 2 2 2 0 Ligand-gated ion channel SCP2 PF02036.15 NM_001324227.1_3 - 1.4e-16 60.6 0.1 6.5e-16 58.5 0.0 2.0 2 1 1 3 3 3 1 SCP-2 sterol transfer family Band_7 PF01145.23 NM_001324227.1_3 - 1.4e-15 57.7 0.0 3.4e-15 56.4 0.0 1.6 2 0 0 2 2 2 1 SPFH domain / Band 7 family DHQS PF01959.14 NM_001324227.1_3 - 0.21 10.3 0.0 0.29 9.8 0.0 1.1 1 0 0 1 1 1 0 3-dehydroquinate synthase (EC 4.6.1.3) DUF4499 PF14934.4 NM_001270373.1_1 - 6.7e-21 74.3 1.3 1.6e-20 73.1 1.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) DUF4499 PF14934.4 NM_001270373.1_2 - 2.6e-05 24.4 1.1 5.9e-05 23.2 1.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) DUF1908 PF08926.9 NM_001319245.1_2 - 4.3e-139 462.3 1.0 1.7e-138 460.3 1.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1908) Pkinase PF00069.23 NM_001319245.1_2 - 6.5e-62 209.1 0.0 9.8e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001319245.1_2 - 3.2e-25 88.7 0.0 6.5e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.22 NM_001319245.1_2 - 7.7e-08 32.4 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001319245.1_2 - 1.1e-06 28.7 0.0 2.7e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain APH PF01636.21 NM_001319245.1_2 - 0.00064 19.6 1.2 0.069 12.9 0.0 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_001319245.1_2 - 0.0023 17.2 0.0 0.0067 15.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Tricorn_PDZ PF14685.4 NM_001319245.1_2 - 0.052 13.4 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain RIO1 PF01163.20 NM_001319245.1_2 - 0.089 12.2 0.1 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Peptidase_C1 PF00112.21 NM_001204414.1_1 - 6e-52 176.8 0.0 9.5e-52 176.1 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Somatomedin_B PF01033.15 NM_001204414.1_1 - 0.011 16.0 16.7 0.048 13.9 16.7 2.1 1 1 0 1 1 1 0 Somatomedin B domain zf-H2C2_2 PF13465.4 NM_007345.3_1 - 1.3e-119 385.7 241.7 2.4e-09 37.1 0.3 32.7 34 0 0 34 34 33 24 Zinc-finger double domain zf-C2H2 PF00096.24 NM_007345.3_1 - 2e-108 349.1 267.8 5.2e-06 26.5 2.1 30.8 30 0 0 30 30 30 30 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_007345.3_1 - 1.5e-82 264.8 257.8 0.00071 20.1 0.4 31.1 30 0 0 30 30 30 28 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_007345.3_1 - 3.9e-40 135.2 160.4 0.0039 17.3 4.3 27.2 28 1 1 29 29 29 18 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_007345.3_1 - 1.4e-16 59.9 215.8 0.00084 19.1 0.3 28.9 28 1 0 28 28 27 18 C2H2-type zinc finger zf-met PF12874.5 NM_007345.3_1 - 3.3e-08 33.5 188.4 0.0079 16.4 0.1 25.2 26 0 0 26 26 26 11 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_007345.3_1 - 0.0023 17.5 6.3 0.0062 16.1 0.7 19.6 22 0 0 22 22 20 7 zinc-finger C2H2-type BolA PF01722.16 NM_007345.3_1 - 0.12 12.5 16.7 41 4.4 0.4 7.5 5 2 1 6 6 6 0 BolA-like protein zinc_ribbon_9 PF14369.4 NM_007345.3_1 - 0.64 10.2 72.4 4.7 7.4 0.3 17.2 17 3 0 17 17 17 0 zinc-ribbon zf-C2H2_2 PF12756.5 NM_007345.3_1 - 1.6 9.0 179.8 0.41 10.9 2.4 24.3 6 6 18 25 25 24 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.10 NM_007345.3_1 - 3.8 7.7 182.8 0.0084 16.2 4.1 19.3 11 7 8 20 20 19 0 Drought induced 19 protein (Di19), zinc-binding MIF4G PF02854.17 NM_001142397.1_3 - 3.5e-27 95.3 5.4 4.9e-27 94.9 5.4 1.1 1 0 0 1 1 1 1 MIF4G domain Sec34 PF04136.13 NM_001142397.1_3 - 0.53 10.0 1.9 0.84 9.4 1.9 1.2 1 0 0 1 1 1 0 Sec34-like family IL6Ra-bind PF09240.8 NM_175727.2_3 - 7.8e-30 103.0 0.1 1.7e-29 101.9 0.1 1.6 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Tissue_fac PF01108.15 NM_175727.2_3 - 1.5e-06 27.8 2.8 0.0042 16.8 0.0 3.6 4 0 0 4 4 4 2 Tissue factor fn3 PF00041.19 NM_175727.2_3 - 0.0051 17.0 0.1 3.7 7.8 0.1 2.8 2 0 0 2 2 2 2 Fibronectin type III domain Hyd_WA PF06462.10 NM_015395.2_1 - 2.2e-72 238.5 56.8 2.3e-11 43.3 4.3 10.3 11 0 0 11 11 11 8 Propeller Pex24p PF06398.9 NM_015395.2_1 - 1.3e-17 63.8 16.2 4.4e-11 42.2 1.3 2.2 2 0 0 2 2 2 2 Integral peroxisomal membrane peroxin PH PF00169.27 NM_015395.2_1 - 0.016 15.6 0.0 0.043 14.2 0.0 1.7 1 0 0 1 1 1 0 PH domain DEP PF00610.19 NM_022783.3_1 - 3.8e-46 154.9 1.3 1.2e-24 86.0 0.3 2.3 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_2 PF13180.4 NM_022783.3_1 - 0.024 14.8 0.0 0.062 13.5 0.0 1.6 1 0 0 1 1 1 0 PDZ domain zf-RING_2 PF13639.4 NM_016494.3_3 - 4.7e-14 52.2 8.4 7.2e-14 51.6 8.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_016494.3_3 - 2e-10 40.2 8.5 3.1e-10 39.6 8.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_016494.3_3 - 9.6e-10 38.5 4.5 1.8e-09 37.6 4.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 NM_016494.3_3 - 6.1e-08 32.3 8.1 9.9e-08 31.6 8.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 NM_016494.3_3 - 8.9e-08 31.6 6.9 1.5e-07 30.8 6.9 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.4 NM_016494.3_3 - 8.8e-07 28.7 5.0 1.3e-06 28.1 5.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_016494.3_3 - 1.1e-06 28.4 6.0 2e-06 27.5 6.0 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 NM_016494.3_3 - 6.9e-06 25.9 0.6 1.1e-05 25.3 0.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.4 NM_016494.3_3 - 1.4e-05 24.8 3.3 2.1e-05 24.2 3.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_016494.3_3 - 5e-05 22.9 7.1 0.00026 20.7 7.4 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-Nse PF11789.6 NM_016494.3_3 - 0.00021 20.9 3.8 0.00034 20.3 3.8 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.3 NM_016494.3_3 - 0.00074 19.0 3.8 0.0012 18.3 3.8 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Rad50_zn_hook PF04423.12 NM_016494.3_3 - 0.0028 17.3 5.1 0.74 9.6 0.1 2.5 2 1 0 2 2 2 2 Rad50 zinc hook motif RINGv PF12906.5 NM_016494.3_3 - 0.027 14.5 6.5 0.054 13.5 6.5 1.5 1 0 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.4 NM_016494.3_3 - 0.05 13.4 2.1 6.4 6.6 0.4 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 FANCL_C PF11793.6 NM_016494.3_3 - 0.37 10.9 5.1 0.25 11.4 2.7 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_4 PF14570.4 NM_016494.3_3 - 0.46 10.1 3.1 0.91 9.2 3.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.4 NM_016494.3_3 - 0.56 10.3 6.4 1.3 9.1 6.5 1.6 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-P11 PF03854.12 NM_016494.3_3 - 0.7 9.5 8.5 2.3 7.8 8.5 1.9 1 1 0 1 1 1 0 P-11 zinc finger zf-H2C2_2 PF13465.4 NM_001290209.1_1 - 2e-122 394.5 191.5 1.7e-08 34.4 2.5 23.3 24 0 0 24 24 24 19 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001290209.1_1 - 6e-80 259.4 215.7 7.1e-07 29.2 0.6 23.0 23 0 0 23 23 23 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001290209.1_1 - 3.4e-37 123.8 202.2 0.0047 17.5 4.7 22.1 23 0 0 23 23 23 18 C2H2-type zinc finger KRAB PF01352.25 NM_001290209.1_1 - 5.6e-22 77.0 1.4 1e-21 76.2 1.4 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001290209.1_1 - 4.6e-18 64.6 138.3 0.046 13.6 0.1 21.5 22 0 0 22 22 22 15 C2H2-type zinc finger XPA_N PF01286.16 NM_001290209.1_1 - 2e-07 30.8 93.4 3.8 7.5 0.1 18.5 18 0 0 18 18 18 11 XPA protein N-terminal Zn-ribbon_8 PF09723.8 NM_001290209.1_1 - 3.1e-07 30.3 123.7 0.059 13.4 4.2 13.3 9 4 5 14 14 14 9 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001290209.1_1 - 7.6e-05 22.8 114.4 0.22 11.8 0.3 18.8 19 0 0 19 19 19 6 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_001290209.1_1 - 0.0057 16.9 77.0 0.19 11.9 0.4 10.1 4 2 5 12 12 12 8 zinc-finger-containing domain zf-H2C2_2 PF13465.4 NM_001290209.1_3 - 3.1e-18 65.2 16.8 4.4e-08 33.1 0.4 4.2 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001290209.1_3 - 4e-11 42.6 14.4 6.7e-05 23.0 0.9 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001290209.1_3 - 0.00018 22.0 16.8 0.032 14.9 0.8 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001290209.1_3 - 0.0058 16.6 2.1 0.0058 16.6 2.1 2.6 2 0 0 2 2 2 1 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001290209.1_3 - 0.012 15.4 16.2 0.14 12.0 0.6 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger C1_4 PF07975.10 NM_001290209.1_3 - 0.19 11.9 6.8 1.4 9.2 0.2 2.3 2 0 0 2 2 2 0 TFIIH C1-like domain C1_1 PF00130.20 NM_001290209.1_3 - 0.62 9.9 7.4 0.33 10.7 1.6 2.3 1 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-AN1 PF01428.14 NM_001290209.1_3 - 0.79 9.8 12.4 0.48 10.5 0.7 3.4 2 1 1 3 3 3 0 AN1-like Zinc finger XPA_N PF01286.16 NM_001290209.1_3 - 1.7 8.6 10.3 6.9 6.7 0.5 3.3 3 0 0 3 3 3 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001290209.1_3 - 2.5 8.8 9.8 8.5 7.1 9.7 1.8 1 1 1 2 2 2 0 zinc-ribbon family DZR PF12773.5 NM_001290209.1_3 - 4.7 7.2 12.3 61 3.6 12.3 2.3 1 1 0 1 1 1 0 Double zinc ribbon YhfH PF14149.4 NM_001290209.1_3 - 7.2 6.6 11.1 11 6.0 0.4 3.2 3 0 0 3 3 3 0 YhfH-like protein ADK_lid PF05191.12 NM_001290209.1_3 - 9.1 6.3 7.3 2.1 8.3 2.2 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid MFS_1 PF07690.14 NM_020309.3_2 - 1.2e-46 159.1 28.6 9.4e-46 156.2 26.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-C3HC4_4 PF15227.4 NM_138800.1_2 - 2e-08 34.1 16.5 2e-08 34.1 16.5 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 NM_138800.1_2 - 1.4e-07 31.6 0.1 5.9e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 SPRY domain zf-C3HC4 PF00097.23 NM_138800.1_2 - 3.1e-06 26.8 14.1 8.9e-06 25.4 14.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_138800.1_2 - 1.2e-05 24.9 14.3 2.7e-05 23.8 14.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_138800.1_2 - 4.4e-05 23.1 12.1 4.4e-05 23.1 12.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_138800.1_2 - 6.9e-05 22.9 14.7 6.9e-05 22.9 14.7 2.0 2 0 0 2 2 1 1 Ring finger domain zf-RING_UBOX PF13445.4 NM_138800.1_2 - 0.0001 22.1 13.2 0.0004 20.2 13.2 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-B_box PF00643.22 NM_138800.1_2 - 0.00081 19.4 6.0 0.00081 19.4 6.0 2.6 3 0 0 3 3 1 1 B-box zinc finger zf-RING_10 PF16685.3 NM_138800.1_2 - 0.01 15.8 7.5 0.032 14.2 7.5 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 BLOC1_2 PF10046.7 NM_138800.1_2 - 0.013 15.7 1.5 0.029 14.6 1.5 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-RING_5 PF14634.4 NM_138800.1_2 - 0.019 14.8 12.5 0.019 14.8 12.5 2.2 2 0 0 2 2 2 0 zinc-RING finger domain TipAS PF07739.11 NM_138800.1_2 - 2 8.9 8.3 0.29 11.6 2.6 2.1 1 1 0 2 2 2 0 TipAS antibiotic-recognition domain zf-RING_4 PF14570.4 NM_138800.1_2 - 9.7 5.9 11.9 30 4.3 11.9 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain COMM_domain PF07258.12 NM_001321844.1_2 - 1.3e-15 57.2 0.0 2.1e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 COMM domain DUF4752 PF15944.3 NM_174912.3_1 - 0.43 10.5 4.3 1.1 9.3 4.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) Amidase PF01425.19 NM_174912.3_3 - 7.3e-78 262.4 0.0 1e-77 261.9 0.0 1.2 1 0 0 1 1 1 1 Amidase Peptidase_C54 PF03416.17 NM_052936.4_2 - 1.5e-99 332.5 0.0 2e-99 332.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 ANF_receptor PF01094.26 NM_001204376.1_3 - 7.9e-26 90.8 0.1 1.1e-25 90.4 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Porphobil_deam PF01379.18 NM_000190.3_2 - 7e-79 264.0 0.0 8.9e-79 263.6 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.13 NM_000190.3_2 - 1.3e-21 76.6 0.0 4.6e-21 74.8 0.0 2.0 2 0 0 2 2 2 1 Porphobilinogen deaminase, C-terminal domain Abhydrolase_3 PF07859.11 NM_207365.3_1 - 7.4e-52 176.1 0.0 2.7e-38 131.8 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.26 NM_207365.3_1 - 3e-08 32.9 0.0 1.1e-07 31.1 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.7 NM_207365.3_1 - 0.00021 20.2 0.0 0.00029 19.7 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Esterase_phd PF10503.7 NM_207365.3_1 - 0.012 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase Peptidase_S9 PF00326.19 NM_207365.3_1 - 0.022 14.1 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Esterase PF00756.18 NM_207365.3_1 - 0.023 14.2 0.0 0.06 12.9 0.0 1.6 1 1 0 1 1 1 0 Putative esterase AXE1 PF05448.10 NM_207365.3_1 - 0.027 13.0 0.0 0.06 11.9 0.0 1.5 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) DUF2974 PF11187.6 NM_207365.3_1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Peptidase_M54 PF07998.9 NM_001033574.1_1 - 3.5e-14 53.1 1.5 2.5e-13 50.3 0.9 2.0 1 1 1 2 2 2 1 Peptidase family M54 Peptidase_M10 PF00413.22 NM_001033574.1_1 - 0.0021 17.8 0.0 0.0046 16.7 0.0 1.5 1 1 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.4 NM_001033574.1_1 - 0.0061 16.9 0.0 0.0098 16.3 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 NM_001033574.1_1 - 0.013 15.5 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M43 PF05572.11 NM_001033574.1_1 - 0.032 14.0 0.7 0.052 13.3 0.4 1.5 1 1 0 1 1 1 0 Pregnancy-associated plasma protein-A Peptidase_M57 PF12388.6 NM_001033574.1_1 - 0.042 13.3 0.8 0.07 12.6 0.1 1.6 2 0 0 2 2 2 0 Dual-action HEIGH metallo-peptidase Reprolysin_4 PF13583.4 NM_001033574.1_1 - 0.15 11.5 0.1 0.28 10.7 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like C2 PF00168.28 NM_020826.2_1 - 9.7e-22 77.1 0.0 4e-13 49.4 0.0 2.4 2 0 0 2 2 2 2 C2 domain Mg_trans_NIPA PF05653.12 NM_001322855.1_1 - 1.4e-71 240.9 21.7 2e-71 240.4 21.7 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA Metallophos PF00149.26 NM_006247.3_2 - 1.3e-36 126.9 0.2 2.3e-36 126.1 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.10 NM_006247.3_2 - 4.1e-32 110.2 1.2 9.1e-32 109.1 1.2 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.26 NM_006247.3_2 - 4.5e-14 51.4 12.8 4.6e-08 32.4 1.0 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_006247.3_2 - 4.7e-14 51.2 8.9 9e-07 28.4 0.5 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.4 NM_006247.3_2 - 3.3e-11 42.6 6.0 2.7e-07 30.0 3.3 3.4 2 1 1 3 3 3 3 TPR repeat TPR_16 PF13432.4 NM_006247.3_2 - 7.3e-09 36.1 1.0 5.7e-05 23.6 0.5 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_006247.3_2 - 4.2e-07 29.9 0.0 0.017 15.1 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_006247.3_2 - 4.3e-07 29.5 3.6 0.00042 20.2 0.4 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_006247.3_2 - 5.3e-05 23.5 0.6 0.14 12.6 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_006247.3_2 - 6.2e-05 23.3 0.2 0.49 11.2 0.0 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_006247.3_2 - 0.0007 19.7 2.5 0.018 15.3 0.5 2.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 NM_006247.3_2 - 0.0055 16.8 3.1 0.036 14.2 1.2 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_006247.3_2 - 0.012 16.0 4.2 1.9 9.1 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.4 NM_006247.3_2 - 0.021 14.7 0.6 0.67 10.0 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.16 NM_006247.3_2 - 0.061 13.3 4.1 0.051 13.5 1.7 2.2 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.4 NM_006247.3_2 - 0.35 10.8 2.1 4.3 7.3 0.1 2.6 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.5 NM_006247.3_2 - 1 9.4 3.9 1.6 8.8 2.2 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 FKBP_C PF00254.26 NM_001135208.1_1 - 1.3e-34 118.3 0.0 2.1e-34 117.6 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Prion PF00377.16 NM_001080123.1_3 - 1e-34 118.7 2.4 1.6e-34 118.1 2.4 1.3 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 NM_001080123.1_3 - 6.7e-17 60.9 4.0 1.5e-16 59.8 4.0 1.6 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal DUF155 PF02582.12 NM_001271937.1_2 - 6.6e-46 156.5 0.8 8.9e-46 156.1 0.8 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 ADAM_spacer1 PF05986.12 NM_001271937.1_2 - 0.062 13.2 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 ADAM-TS Spacer 1 zf-C2H2 PF00096.24 NM_001135734.2_1 - 3.3e-34 115.3 77.5 5.7e-05 23.2 3.3 8.7 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001135734.2_1 - 8.6e-33 111.2 71.1 8.8e-06 25.8 0.3 9.1 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001135734.2_1 - 5.7e-20 70.1 70.1 0.0017 18.9 1.0 8.7 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001135734.2_1 - 5.2e-06 26.5 52.2 0.0096 16.1 0.5 7.9 7 1 1 8 8 7 4 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.4 NM_001135734.2_1 - 6.9e-06 25.7 22.4 0.0065 16.2 0.4 5.9 6 0 0 6 6 6 2 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.4 NM_001135734.2_1 - 3.2e-05 23.6 57.4 0.00033 20.4 0.1 8.4 8 0 0 8 8 8 5 C2H2-type zinc finger zf-Di19 PF05605.10 NM_001135734.2_1 - 0.00038 20.5 47.4 0.015 15.4 7.0 5.2 4 2 1 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.3 NM_001135734.2_1 - 0.0028 17.3 21.5 0.58 9.8 0.3 5.7 5 0 0 5 5 5 2 zinc-finger C2H2-type API5 PF05918.9 NM_001135734.2_1 - 0.039 12.6 9.6 0.073 11.7 9.6 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) zf-met PF12874.5 NM_001135734.2_1 - 0.11 12.8 67.5 0.1 12.9 1.5 8.6 8 0 0 8 8 8 0 Zinc-finger of C2H2 type DUF2360 PF10152.7 NM_001135734.2_1 - 0.29 11.4 9.4 0.71 10.1 9.4 1.7 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Pex14_N PF04695.11 NM_001135734.2_1 - 0.32 11.6 18.1 1 9.9 18.1 1.8 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TerY_C PF15616.4 NM_001135734.2_1 - 0.57 10.2 11.7 2.4 8.1 0.2 3.5 1 1 3 4 4 4 0 TerY-C metal binding domain zf-C2HE PF16278.3 NM_001135734.2_1 - 1.5 9.2 41.6 0.83 10.0 3.6 5.9 2 1 3 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger DUF4407 PF14362.4 NM_001135734.2_1 - 1.9 7.6 11.9 3 7.0 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Zn-ribbon_8 PF09723.8 NM_001135734.2_1 - 3.1 7.9 29.8 0.15 12.0 2.4 5.0 3 1 2 5 5 5 0 Zinc ribbon domain RR_TM4-6 PF06459.10 NM_001135734.2_1 - 7.2 6.2 9.6 13 5.4 9.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Suf PF05843.12 NM_001135734.2_1 - 7.3 6.3 15.8 16 5.2 15.8 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RRM_1 PF00076.20 NM_001323529.1_1 - 5.7e-21 74.0 0.1 2.2e-12 46.5 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001323529.1_1 - 0.0065 15.9 0.0 0.054 13.0 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4074 PF13293.4 NM_153631.2_1 - 1.9e-30 104.8 7.8 4.9e-30 103.5 7.8 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4074) Homeobox PF00046.27 NM_153631.2_1 - 7.7e-21 73.5 4.9 1.4e-20 72.7 4.9 1.4 1 0 0 1 1 1 1 Homeobox domain Neur_chan_LBD PF02931.21 NM_004961.3_1 - 3.8e-46 157.1 1.0 5.3e-46 156.6 1.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_004961.3_1 - 1.5e-29 103.6 2.4 2.6e-26 93.0 0.1 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Pkinase PF00069.23 NM_001145001.2_1 - 1.6e-65 221.0 0.0 2.1e-65 220.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001145001.2_1 - 3.1e-46 157.6 0.0 4.3e-46 157.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001145001.2_1 - 7.3e-05 22.1 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001145001.2_1 - 0.012 14.8 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family 7tm_1 PF00001.19 NM_003301.5_3 - 3.3e-50 170.7 25.4 4.4e-50 170.3 25.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_003301.5_3 - 7.2e-10 38.5 24.5 1.2e-09 37.9 24.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_003301.5_3 - 4.8e-05 23.1 18.7 6e-05 22.8 12.0 2.3 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 NM_003301.5_3 - 0.00091 18.5 18.7 0.00091 18.5 18.7 2.5 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx ISK_Channel PF02060.13 NM_003301.5_3 - 0.005 16.4 1.5 0.27 10.8 0.1 2.5 2 1 0 2 2 2 1 Slow voltage-gated potassium channel Pkinase_Tyr PF07714.15 NM_001982.3_1 - 1.4e-77 260.4 0.0 1.9e-77 259.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 NM_001982.3_1 - 1e-61 205.8 0.3 1e-29 102.7 0.0 2.3 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 NM_001982.3_1 - 1.2e-53 180.3 79.6 3.4e-48 162.6 29.0 4.1 2 1 1 3 3 3 2 Growth factor receptor domain IV Furin-like PF00757.18 NM_001982.3_1 - 4.5e-36 123.8 84.7 5.4e-31 107.4 36.3 4.4 2 1 2 4 4 4 3 Furin-like cysteine rich region Pkinase PF00069.23 NM_001982.3_1 - 1.2e-32 113.2 0.0 1.9e-32 112.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 NM_001982.3_1 - 0.037 13.2 0.0 0.072 12.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Pmp3 PF01679.15 NM_001982.3_2 - 2.9 8.0 6.7 2.1 8.5 1.3 2.8 2 0 0 2 2 2 0 Proteolipid membrane potential modulator bZIP_1 PF00170.19 NM_182771.1_2 - 2.5e-20 72.2 9.8 4.3e-20 71.5 9.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.15 NM_182771.1_2 - 4.9e-19 67.4 1.1 4.9e-19 67.4 1.1 2.2 2 0 0 2 2 2 1 pKID domain bZIP_2 PF07716.13 NM_182771.1_2 - 1e-06 28.6 11.2 1.7e-06 27.8 11.2 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_182771.1_2 - 0.0093 16.3 5.6 0.017 15.5 5.6 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Atg14 PF10186.7 NM_001258300.1_1 - 0.001 18.1 8.0 0.001 18.1 8.0 3.2 2 1 0 3 3 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.9 NM_001258300.1_1 - 0.0018 17.1 19.0 0.0018 17.1 19.0 3.3 1 1 2 3 3 3 1 Spc7 kinetochore protein PRIMA1 PF16101.3 NM_001258300.1_1 - 6.2 6.8 15.4 3.5 7.5 10.7 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Myosin_N PF02736.17 NM_001291913.1_2 - 0.078 12.7 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain GTSE1_N PF15259.4 NM_001032291.2_1 - 3.3e-09 36.9 0.0 1.4e-08 34.9 0.0 1.8 1 1 0 1 1 1 1 G-2 and S-phase expressed 1 MARVEL PF01284.21 NM_001205254.1_3 - 1.5e-25 89.7 11.9 4.2e-25 88.3 11.9 1.8 1 0 0 1 1 1 1 Membrane-associating domain Occludin_ELL PF07303.11 NM_001205254.1_3 - 2.6e-25 88.9 9.5 4.1e-25 88.3 9.5 1.3 1 0 0 1 1 1 1 Occludin homology domain Laminin_II PF06009.10 NM_001205254.1_3 - 0.037 13.9 1.2 0.06 13.2 1.2 1.2 1 0 0 1 1 1 0 Laminin Domain II APG6 PF04111.10 NM_001205254.1_3 - 0.31 10.3 7.5 0.46 9.7 7.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4164 PF13747.4 NM_001205254.1_3 - 0.43 10.7 1.9 0.74 10.0 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) TMF_TATA_bd PF12325.6 NM_001205254.1_3 - 0.54 10.4 4.0 0.86 9.7 4.0 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF342 PF03961.11 NM_001205254.1_3 - 0.9 7.9 3.3 1.3 7.4 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4200 PF13863.4 NM_001205254.1_3 - 1.2 9.4 10.6 1.8 8.9 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) PRKG1_interact PF15898.3 NM_001205254.1_3 - 2.2 9.1 8.0 4.2 8.2 8.0 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Swi5 PF07061.9 NM_001205254.1_3 - 3.8 7.5 5.7 1.3 9.0 2.7 1.8 2 0 0 2 2 2 0 Swi5 Copine PF07002.14 NM_130808.2_2 - 7.5e-95 316.4 0.0 1e-94 316.0 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.28 NM_130808.2_2 - 2e-25 88.9 0.1 6.4e-12 45.5 0.1 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 NM_130808.2_2 - 0.00013 22.0 0.0 0.00022 21.3 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.26 NM_130808.2_2 - 0.0029 17.8 0.0 0.0049 17.0 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain RUN PF02759.17 NM_001134405.1_1 - 5.8e-25 87.7 0.0 1.1e-24 86.8 0.0 1.5 1 0 0 1 1 1 1 RUN domain zf-H2C2_2 PF13465.4 NM_017560.1_1 - 1.4e-30 104.2 28.0 2.7e-08 33.7 0.4 6.5 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.24 NM_017560.1_1 - 9.5e-27 91.8 29.6 6.3e-06 26.2 0.7 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_017560.1_1 - 3.5e-10 39.7 48.1 0.0028 18.2 0.5 6.3 6 0 0 6 6 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_017560.1_1 - 9.5e-07 28.8 9.1 0.018 15.2 0.3 5.2 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_017560.1_1 - 0.054 13.5 17.9 0.23 11.5 3.1 4.5 1 1 5 6 6 6 0 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_017560.1_1 - 0.19 11.6 24.4 1.8 8.5 0.7 5.6 5 0 0 5 5 5 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 NM_017560.1_1 - 0.49 11.0 11.7 1.6 9.4 0.4 3.6 2 1 2 4 4 3 0 zinc-ribbon family XPA_N PF01286.16 NM_017560.1_1 - 0.63 10.0 10.6 19 5.2 0.1 5.0 5 0 0 5 5 5 0 XPA protein N-terminal Zn_ribbon_recom PF13408.4 NM_017560.1_1 - 2.3 8.7 21.2 6.5 7.2 3.4 4.2 2 2 2 4 4 4 0 Recombinase zinc beta ribbon domain C1_4 PF07975.10 NM_017560.1_1 - 3.3 7.9 9.9 2.2 8.5 0.4 3.7 2 1 1 3 3 3 0 TFIIH C1-like domain DNA_RNApol_7kD PF03604.11 NM_017560.1_1 - 5 6.7 15.9 1.9 8.1 0.1 4.9 5 0 0 5 5 5 0 DNA directed RNA polymerase, 7 kDa subunit CBF PF03914.15 NM_005760.2_1 - 6.5e-55 185.4 2.5 1.2e-54 184.6 0.1 2.5 2 1 0 2 2 2 1 CBF/Mak21 family Cnd1 PF12717.5 NM_005760.2_1 - 0.0028 17.5 2.8 0.0041 17.0 0.4 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Pro_dh-DNA_bdg PF14850.4 NM_005760.2_1 - 0.029 14.7 0.2 1.1 9.7 0.1 2.7 2 0 0 2 2 2 0 DNA-binding domain of Proline dehydrogenase GoLoco PF02188.15 NM_001321039.1_2 - 2.8e-37 125.6 32.2 1.3e-09 37.2 0.2 4.6 4 0 0 4 4 4 4 GoLoco motif TPR_12 PF13424.4 NM_001321039.1_2 - 2.5e-36 123.7 28.6 1.2e-10 41.4 5.7 5.4 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001321039.1_2 - 2.5e-32 109.2 28.7 1.6e-05 24.4 0.0 7.7 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001321039.1_2 - 6e-27 91.5 19.3 2.5e-05 23.8 0.4 8.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001321039.1_2 - 1.5e-18 65.2 22.2 0.0036 17.2 0.7 7.6 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001321039.1_2 - 1.6e-17 62.0 19.7 0.00094 19.1 0.5 7.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001321039.1_2 - 8.7e-16 57.1 20.6 0.016 15.0 0.0 7.7 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_4 PF07721.12 NM_001321039.1_2 - 1.8e-06 27.9 0.0 1.8 9.3 0.1 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat Rapsyn_N PF10579.7 NM_001321039.1_2 - 0.00052 19.9 0.6 16 5.6 0.1 4.2 3 2 1 4 4 4 0 Rapsyn N-terminal myristoylation and linker region TPR_14 PF13428.4 NM_001321039.1_2 - 0.0017 18.9 4.8 36 5.4 0.0 6.2 5 2 2 7 7 6 0 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001321039.1_2 - 0.0059 17.1 10.3 2.9 8.5 0.2 5.4 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001321039.1_2 - 0.99 9.8 14.2 55 4.3 0.0 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001321039.1_2 - 1.3 8.6 22.0 0.73 9.4 0.4 6.4 6 1 0 6 6 6 0 TPR repeat ANAPC3 PF12895.5 NM_001321039.1_2 - 1.4 9.0 12.4 6.5 6.9 1.8 4.2 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 NM_001321039.1_2 - 2.7 8.7 4.6 1.5e+02 3.2 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat fn3 PF00041.19 NM_003285.2_1 - 4.3e-120 392.2 28.7 7.1e-16 58.2 1.0 9.4 9 0 0 9 9 9 9 Fibronectin type III domain Fibrinogen_C PF00147.16 NM_003285.2_1 - 2.9e-82 275.6 6.2 4.5e-82 275.0 6.2 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_2 PF07974.11 NM_003285.2_1 - 4.4e-17 62.0 85.5 8.9e-05 22.6 11.8 5.7 5 0 0 5 5 5 5 EGF-like domain Pur_ac_phosph_N PF16656.3 NM_003285.2_1 - 3e-11 43.6 20.7 0.75 10.3 0.0 10.3 9 3 0 9 9 9 5 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 NM_003285.2_1 - 5.2e-07 29.9 1.2 9.7 6.6 0.0 7.1 9 0 0 9 9 8 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 NM_003285.2_1 - 5.3e-07 29.8 0.0 3.4 7.9 0.0 7.2 8 0 0 8 8 8 1 Interferon-alpha/beta receptor, fibronectin type III CBM_4_9 PF02018.15 NM_003285.2_1 - 0.00018 21.6 0.6 1.3 9.2 0.0 5.1 4 1 1 6 6 5 1 Carbohydrate binding domain DUF4998 PF16389.3 NM_003285.2_1 - 0.00026 20.5 0.0 7.1 6.0 0.0 4.4 5 0 0 5 5 5 2 Domain of unknown function Uroplakin_II PF07353.10 NM_003285.2_1 - 0.0025 17.2 0.3 0.57 9.5 0.0 3.4 4 0 0 4 4 4 1 Uroplakin II Tissue_fac PF01108.15 NM_003285.2_1 - 0.015 14.9 6.2 4.2 7.1 0.0 5.3 5 1 0 5 5 5 0 Tissue factor PepSY PF03413.17 NM_003285.2_1 - 0.16 12.5 1.8 9.7 6.7 0.1 3.8 5 0 0 5 5 4 0 Peptidase propeptide and YPEB domain EGF PF00008.25 NM_003285.2_1 - 1.1 9.5 72.9 0.1 12.8 7.4 5.6 5 0 0 5 5 5 0 EGF-like domain Sin_N PF04801.11 NM_001258036.1_1 - 1.4e-157 525.2 1.4 1.9e-157 524.8 1.4 1.2 1 0 0 1 1 1 1 Sin-like protein conserved region muHD PF10291.7 NM_138782.2_3 - 1.7e-67 227.5 0.0 2.6e-67 226.9 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.21 NM_138782.2_3 - 1.2e-18 67.0 0.0 1.2e-18 67.0 0.0 2.4 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain DUF1664 PF07889.10 NM_138782.2_3 - 5.8 6.8 12.2 2 8.3 2.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Na_Pi_cotrans PF02690.13 NM_001167579.1_3 - 1.7e-25 89.6 6.5 2.8e-25 88.9 6.5 1.3 1 0 0 1 1 1 1 Na+/Pi-cotransporter IRK PF01007.18 NM_170736.2_1 - 5.6e-136 452.7 1.7 8.7e-136 452.1 1.7 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_170736.2_1 - 0.0083 15.9 3.4 0.019 14.8 3.4 1.6 1 0 0 1 1 1 1 Ion channel DUF2182 PF09948.7 NM_170736.2_1 - 0.12 12.1 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) Dysbindin PF04440.14 NM_018478.3_1 - 6.2e-30 104.2 1.8 9e-30 103.6 1.8 1.2 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) PRIMA1 PF16101.3 NM_018478.3_2 - 4.1 7.3 9.8 9.4 6.2 9.8 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Na_Ca_ex PF01699.22 NM_153646.3_3 - 2e-54 183.6 46.6 3.6e-28 98.3 14.1 2.8 3 0 0 3 3 3 2 Sodium/calcium exchanger protein DUF788 PF05620.9 NM_153646.3_3 - 1.9 8.2 4.2 5.3 6.8 4.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF788) Bud13 PF09736.7 NM_032725.3_2 - 3.3e-50 170.1 11.9 3.3e-50 170.1 11.9 2.3 2 1 1 3 3 3 1 Pre-mRNA-splicing factor of RES complex Autophagy_act_C PF03987.13 NM_031482.4_1 - 3.5e-18 65.8 0.6 6.8e-18 64.9 0.6 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain HIG_1_N PF04588.11 NM_001271880.1_3 - 2.3e-15 56.4 1.0 3.3e-15 55.9 1.0 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Chlam_OMP PF01308.15 NM_001286800.1_1 - 0.18 10.4 0.2 0.28 9.8 0.2 1.2 1 0 0 1 1 1 0 Chlamydia major outer membrane protein Methyltransf_PK PF05891.10 NM_001286800.1_2 - 8.7e-30 103.7 0.0 1.2e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_PK PF05891.10 NM_001286800.1_3 - 2.3e-38 131.8 0.0 3.2e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.4 NM_001286800.1_3 - 0.0081 16.7 0.0 0.014 16.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_001286800.1_3 - 0.14 12.8 0.0 0.22 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DEAD PF00270.27 NM_001257191.2_2 - 1.6e-41 141.8 0.4 1.6e-41 141.8 0.4 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001257191.2_2 - 7.6e-27 93.8 0.8 2.6e-26 92.1 0.5 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.4 NM_001257191.2_2 - 0.0028 16.9 0.2 0.0048 16.1 0.2 1.2 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit MARVEL PF01284.21 NM_001290193.1_2 - 1.2e-34 119.3 32.2 8e-20 71.2 5.7 3.0 2 0 0 2 2 2 2 Membrane-associating domain Period_C PF12114.6 NM_001289862.1_1 - 1.1e-35 122.9 4.6 1.1e-35 122.9 4.6 3.4 4 0 0 4 4 4 1 Period protein 2/3C-terminal region PAS_3 PF08447.10 NM_001289862.1_1 - 9.5e-14 51.3 0.0 3.5e-13 49.5 0.0 2.0 3 0 0 3 3 3 1 PAS fold PAS PF00989.23 NM_001289862.1_1 - 3e-09 36.8 0.0 3.6e-07 30.1 0.0 2.6 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.4 NM_001289862.1_1 - 7.6e-08 32.3 0.0 2.4e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 PAS domain DNA_Packaging PF11053.6 NM_001289862.1_1 - 0.16 11.7 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Terminase DNA packaging enzyme DnaJ PF00226.29 NM_001135110.2_3 - 1.2e-27 95.7 6.7 1.8e-27 95.1 6.7 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.16 NM_001135110.2_3 - 4.5e-25 88.3 0.0 6e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.17 NM_001135110.2_3 - 1.9e-10 40.9 15.0 3.7e-10 39.9 15.0 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.3 NM_001135110.2_3 - 5.5 6.9 14.0 2.6 7.9 4.7 3.0 1 1 3 4 4 4 0 Tryptophan RNA-binding attenuator protein inhibitory protein Phtf-FEM1B_bdg PF12129.6 NM_001323043.1_3 - 3.5e-69 231.4 3.3 8.9e-69 230.1 3.3 1.7 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor BPL_LplA_LipB PF03099.17 NM_145198.2_2 - 0.0029 17.4 0.0 0.0056 16.4 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family ATP11 PF06644.9 NM_001042546.2_1 - 6e-20 72.0 0.7 4e-14 52.9 0.1 2.2 1 1 1 2 2 2 2 ATP11 protein Bradykinin PF06753.10 NM_001206646.1_2 - 0.14 11.7 1.9 0.43 10.2 1.9 1.8 1 0 0 1 1 1 0 Bradykinin Kelch_1 PF01344.23 NM_139322.3_1 - 2.3e-27 94.2 6.4 1.1e-05 24.7 0.1 7.1 6 0 0 6 6 6 6 Kelch motif Lectin_C PF00059.19 NM_139322.3_1 - 1.2e-20 74.1 0.2 1.2e-20 74.1 0.2 2.9 3 0 0 3 3 1 1 Lectin C-type domain Kelch_6 PF13964.4 NM_139322.3_1 - 1.3e-19 69.6 8.9 1.8e-06 27.9 0.0 6.7 6 0 0 6 6 6 5 Kelch motif PSI PF01437.23 NM_139322.3_1 - 7.5e-17 61.5 53.8 9e-13 48.4 11.3 8.5 8 1 0 8 8 5 5 Plexin repeat Kelch_5 PF13854.4 NM_139322.3_1 - 8.9e-16 57.4 21.5 0.00011 21.9 0.1 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.4 NM_139322.3_1 - 1.2e-14 54.0 8.7 0.073 13.2 0.0 7.6 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_4 PF13418.4 NM_139322.3_1 - 1.7e-14 53.3 8.2 0.11 12.4 0.1 6.8 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_139322.3_1 - 3.9e-14 51.8 9.1 0.21 11.5 0.1 7.0 6 0 0 6 6 6 5 Kelch motif CUB PF00431.18 NM_139322.3_1 - 1.8e-13 50.7 0.0 5.2e-13 49.2 0.0 1.9 1 0 0 1 1 1 1 CUB domain Laminin_EGF PF00053.22 NM_139322.3_1 - 0.0014 18.6 16.6 0.0014 18.6 16.6 9.4 8 2 2 10 10 5 3 Laminin EGF domain EGF_2 PF07974.11 NM_139322.3_1 - 0.0029 17.8 11.6 0.0029 17.8 11.6 10.6 8 1 0 8 8 6 2 EGF-like domain EGF PF00008.25 NM_139322.3_1 - 0.0061 16.7 4.8 0.0061 16.7 4.8 8.4 10 0 0 10 10 5 2 EGF-like domain PSI_integrin PF17205.1 NM_139322.3_1 - 0.0065 16.1 9.2 0.0065 16.1 9.2 7.0 6 1 0 6 6 5 3 Integrin plexin domain 7tm_1 PF00001.19 NM_001145284.3_3 - 1.9e-58 197.7 28.2 3.2e-58 196.9 28.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001145284.3_3 - 1.5e-08 34.2 26.8 2.4e-08 33.6 26.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001145284.3_3 - 5.4e-05 22.5 27.9 5.4e-05 22.5 27.9 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 NM_001145284.3_3 - 0.0041 16.8 20.5 0.0081 15.8 20.5 1.4 1 1 0 1 1 1 1 Olfactory receptor Peptidase_M18 PF02127.13 NM_001319117.1_2 - 3.2e-173 576.3 0.0 1.8e-93 313.5 0.0 2.1 1 1 1 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.12 NM_001319117.1_2 - 6.1e-05 22.0 0.0 0.00016 20.7 0.0 1.6 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase CALCOCO1 PF07888.9 NM_001002837.2_3 - 5.9e-06 25.0 0.2 8e-06 24.6 0.2 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Exo_endo_phos PF03372.21 NM_001002837.2_3 - 1.8e-05 24.9 0.0 2.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1725 PF08333.9 NM_032714.2_1 - 0.0011 18.4 0.1 0.0019 17.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Drf_GBD PF06371.11 NM_032714.2_3 - 2e-17 63.2 0.0 2.9e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.14 NM_032714.2_3 - 2.3e-16 59.9 0.0 3.3e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 Diaphanous FH3 Domain DUF4561 PF15120.4 NM_001316897.1_3 - 5.9e-81 270.0 1.1 8.1e-81 269.6 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4561) ZapA PF05164.11 NM_001316897.1_3 - 0.06 13.6 0.1 9.4 6.6 0.0 2.3 2 0 0 2 2 2 0 Cell division protein ZapA Glycos_transf_2 PF00535.24 NM_003859.2_3 - 5.8e-38 130.2 0.0 7.4e-38 129.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.4 NM_003859.2_3 - 1.2e-11 44.9 0.0 2.2e-11 44.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.7 NM_003859.2_3 - 0.0001 21.7 0.0 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.4 NM_003859.2_3 - 0.0002 20.7 0.0 0.00036 19.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.4 NM_003859.2_3 - 0.095 13.1 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 HAGH_C PF16123.3 NM_032304.3_1 - 1.1e-20 73.8 0.0 1.6e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 NM_032304.3_1 - 6.3e-11 42.5 1.5 7e-10 39.1 1.5 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 NM_032304.3_1 - 0.00053 19.4 0.2 0.0012 18.2 0.1 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Bacteriocin_IIc PF10439.7 NM_003776.3_2 - 5 7.2 6.9 0.18 11.9 0.8 1.9 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide MRP-L28 PF09812.7 NM_003776.3_3 - 1.4e-60 204.0 13.3 1.9e-60 203.5 13.3 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 LRR_8 PF13855.4 NM_001271946.1_1 - 5.2e-107 349.5 92.5 3.8e-15 55.3 0.9 10.9 4 4 7 11 11 11 11 Leucine rich repeat EGF PF00008.25 NM_001271946.1_1 - 9.2e-47 156.8 135.7 3.8e-07 30.1 6.5 11.7 10 0 0 10 10 9 9 EGF-like domain LRR_5 PF13306.4 NM_001271946.1_1 - 3.7e-42 143.2 3.8 2.1e-10 40.5 0.2 5.3 4 1 1 5 5 5 5 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_001271946.1_1 - 3.8e-37 125.4 66.5 1.4e-05 25.1 0.0 12.9 8 4 7 15 15 15 13 Leucine Rich repeats (2 copies) Laminin_G_2 PF02210.22 NM_001271946.1_1 - 6e-23 81.7 0.0 9.7e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain LRR_9 PF14580.4 NM_001271946.1_1 - 9.3e-23 80.5 30.0 1.2e-06 28.0 1.2 6.3 4 2 2 6 6 6 6 Leucine-rich repeat hEGF PF12661.5 NM_001271946.1_1 - 2.1e-22 78.8 122.8 2.1e-05 24.9 6.4 12.5 12 0 0 12 12 10 9 Human growth factor-like EGF LRRNT PF01462.16 NM_001271946.1_1 - 1.4e-20 72.4 60.3 1e-08 34.4 2.8 8.2 9 0 0 9 9 8 4 Leucine rich repeat N-terminal domain Laminin_G_1 PF00054.21 NM_001271946.1_1 - 3.7e-19 69.1 0.0 6.3e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain LRRCT PF01463.22 NM_001271946.1_1 - 1.2e-10 41.0 28.7 0.0086 16.4 0.2 7.1 7 0 0 7 7 6 4 Leucine rich repeat C-terminal domain Laminin_G_3 PF13385.4 NM_001271946.1_1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily LRR_1 PF00560.31 NM_001271946.1_1 - 0.61 10.6 48.1 12 6.7 0.0 15.3 16 1 0 16 16 14 0 Leucine Rich Repeat Pkinase PF00069.23 NM_024011.3_1 - 1.6e-66 224.3 0.0 4.8e-66 222.7 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_024011.3_1 - 1.1e-30 106.7 0.4 3.2e-30 105.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_024011.3_1 - 2.5e-06 26.9 0.2 0.00018 20.8 0.0 2.4 1 1 0 2 2 2 2 Kinase-like Folate_rec PF03024.12 NM_001270440.1_1 - 5.4e-28 97.9 3.5 9.6e-28 97.1 3.5 1.3 1 0 0 1 1 1 1 Folate receptor family zf-C2H2 PF00096.24 NM_001159296.2_2 - 5.7e-09 35.8 13.1 0.0002 21.5 5.5 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001159296.2_2 - 4e-06 26.9 1.8 4e-06 26.9 1.8 3.4 2 1 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001159296.2_2 - 0.028 15.1 20.5 0.058 14.1 3.0 4.4 3 0 0 3 3 3 0 C2H2-type zinc finger SPT_ssu-like PF11779.6 NM_001040100.1_1 - 1.2e-14 53.5 5.4 2.6e-14 52.4 5.4 1.6 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like DEAD PF00270.27 NM_013264.4_3 - 2.1e-29 102.4 0.0 4.4e-29 101.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_013264.4_3 - 4.4e-27 94.5 0.1 8.9e-27 93.5 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_013264.4_3 - 0.001 19.0 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit NmrA PF05368.11 NM_001305141.1_3 - 4.1e-47 160.6 0.0 5.4e-47 160.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.4 NM_001305141.1_3 - 2.4e-10 40.5 0.0 3.2e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.16 NM_001305141.1_3 - 4.5e-05 23.5 0.1 9.4e-05 22.5 0.1 1.5 1 1 0 1 1 1 1 TrkA-N domain KR PF08659.8 NM_001305141.1_3 - 0.0042 16.9 0.1 0.0082 15.9 0.1 1.4 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.16 NM_001305141.1_3 - 0.0083 16.3 0.1 0.028 14.5 0.1 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.19 NM_001305141.1_3 - 0.01 15.2 0.1 0.016 14.5 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.17 NM_001305141.1_3 - 0.013 14.4 0.0 0.017 14.0 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.15 NM_001305141.1_3 - 0.036 14.5 0.1 0.083 13.4 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.23 NM_001305141.1_3 - 0.13 11.6 0.4 0.26 10.6 0.2 1.5 2 0 0 2 2 2 0 short chain dehydrogenase LSM PF01423.20 NM_001139499.1_1 - 7.4e-19 67.1 0.6 1.1e-18 66.5 0.6 1.3 1 0 0 1 1 1 1 LSM domain Mg_trans_NIPA PF05653.12 NM_001322864.1_3 - 9.6e-72 241.4 21.1 1.3e-71 241.0 21.1 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA DnaJ_C PF01556.16 NM_006145.2_1 - 3.4e-42 143.9 0.1 4.5e-42 143.5 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 NM_006145.2_1 - 8.4e-27 92.9 1.0 1.3e-26 92.3 1.0 1.3 1 0 0 1 1 1 1 DnaJ domain IBR PF01485.19 NM_001029860.3_2 - 3.4e-05 23.9 7.7 7.8e-05 22.7 7.7 1.6 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain F-box PF00646.31 NM_001029860.3_2 - 0.0017 18.0 0.2 0.004 16.8 0.2 1.5 1 0 0 1 1 1 1 F-box domain DUF4566 PF15130.4 NM_001029860.3_2 - 0.0095 15.3 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4566) F-box-like PF12937.5 NM_001029860.3_2 - 0.033 13.9 0.1 0.073 12.8 0.1 1.5 1 0 0 1 1 1 0 F-box-like IPK PF03770.14 NM_001142883.1_3 - 6e-63 212.1 0.0 7.9e-63 211.8 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase Ig_3 PF13927.4 NM_001159920.1_1 - 2e-43 146.8 6.1 4.4e-08 33.5 0.1 6.5 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 NM_001159920.1_1 - 2.7e-36 123.4 1.1 1.2e-07 31.5 0.0 6.8 6 1 0 6 6 6 5 Immunoglobulin I-set domain ig PF00047.23 NM_001159920.1_1 - 2.1e-29 101.4 12.5 1.5e-09 37.8 0.2 7.1 6 2 0 6 6 6 6 Immunoglobulin domain Ig_2 PF13895.4 NM_001159920.1_1 - 4.4e-23 81.3 12.5 6.5e-06 26.3 0.0 7.2 6 1 0 6 6 6 6 Immunoglobulin domain V-set PF07686.15 NM_001159920.1_1 - 3.8e-17 62.3 5.4 8.7e-06 25.7 0.1 6.5 5 1 0 5 5 5 3 Immunoglobulin V-set domain C1-set PF07654.13 NM_001159920.1_1 - 6.7e-05 23.2 7.2 0.0043 17.3 0.0 3.9 4 0 0 4 4 4 2 Immunoglobulin C1-set domain Adeno_E3_CR1 PF02440.13 NM_001159920.1_1 - 0.28 10.9 8.5 0.058 13.0 0.2 3.7 4 0 0 4 4 4 0 Adenovirus E3 region protein CR1 Marek_A PF02124.13 NM_001159920.1_1 - 0.59 9.8 3.1 0.9 9.2 0.1 2.5 3 0 0 3 3 3 0 Marek's disease glycoprotein A Pex16 PF08610.8 NM_057174.2_1 - 1.2e-80 270.9 1.2 1.6e-80 270.6 1.2 1.1 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Kelch_4 PF13418.4 NM_001271938.1_3 - 9.1e-41 137.5 22.3 1.1e-09 38.0 0.1 10.4 10 1 1 11 11 11 7 Galactose oxidase, central domain Kelch_3 PF13415.4 NM_001271938.1_3 - 2.4e-40 136.0 40.2 4.1e-07 30.0 0.2 12.7 12 1 0 12 12 11 8 Galactose oxidase, central domain Kelch_6 PF13964.4 NM_001271938.1_3 - 7.1e-28 95.8 17.2 0.00011 22.2 0.0 11.8 10 2 2 12 12 12 6 Kelch motif Kelch_5 PF13854.4 NM_001271938.1_3 - 1.9e-26 91.4 27.7 0.00035 20.3 0.0 10.9 11 0 0 11 11 11 8 Kelch motif Kelch_1 PF01344.23 NM_001271938.1_3 - 7e-23 79.8 3.8 0.13 11.8 0.0 10.7 11 0 0 11 11 11 6 Kelch motif CUB PF00431.18 NM_001271938.1_3 - 3.7e-15 56.1 0.0 3.2e-14 53.1 0.0 2.3 3 0 0 3 3 2 1 CUB domain Kelch_2 PF07646.13 NM_001271938.1_3 - 5.2e-10 38.8 22.2 3 7.8 0.1 11.1 12 0 0 12 12 12 4 Kelch motif Laminin_EGF PF00053.22 NM_001271938.1_3 - 8.8e-09 35.2 14.7 8.8e-09 35.2 14.7 19.2 14 6 5 19 19 11 6 Laminin EGF domain EGF_3 PF12947.5 NM_001271938.1_3 - 9.8e-09 35.1 1.5 9.8e-09 35.1 1.5 11.3 12 2 2 14 14 7 2 EGF domain PSI PF01437.23 NM_001271938.1_3 - 6.8e-08 32.8 27.0 5.9e-07 29.8 6.5 18.2 15 5 1 16 16 12 8 Plexin repeat EGF_CA PF07645.13 NM_001271938.1_3 - 2e-07 31.0 6.3 2e-07 31.0 6.3 14.3 11 5 6 17 17 7 2 Calcium-binding EGF domain PSI_integrin PF17205.1 NM_001271938.1_3 - 7.1e-05 22.4 21.2 0.00013 21.6 6.0 14.2 14 1 1 15 15 11 4 Integrin plexin domain EGF_2 PF07974.11 NM_001271938.1_3 - 0.00065 19.9 8.5 0.00065 19.9 8.5 18.0 18 1 1 19 19 11 3 EGF-like domain Ribosomal_L6e PF01159.17 NM_001024662.2_1 - 2e-44 150.4 1.5 2e-44 150.4 1.5 2.6 3 0 0 3 3 3 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.13 NM_001024662.2_1 - 3.3e-35 119.9 13.7 3.3e-35 119.9 13.7 2.9 4 0 0 4 4 4 1 Ribosomal protein L6, N-terminal domain PH PF00169.27 NM_001318868.1_2 - 8.1e-09 35.8 0.0 1.1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 PH domain HemS PF05171.10 NM_001318868.1_2 - 0.22 11.4 0.0 0.39 10.5 0.0 1.3 1 0 0 1 1 1 0 Haemin-degrading HemS.ChuX domain IRS PF02174.15 NM_001318868.1_3 - 7.3e-14 51.3 0.0 1.2e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 PTB domain (IRS-1 type) TGF_beta PF00019.18 NM_001288824.2_3 - 3.2e-26 92.1 0.2 6.4e-26 91.1 0.2 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain CAMSAP_CKK PF08683.9 NM_001288824.2_3 - 0.053 13.6 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Microtubule-binding calmodulin-regulated spectrin-associated DMRT-like PF15791.3 NM_001040283.2_3 - 3.1e-52 175.9 8.4 3.1e-52 175.9 8.4 1.9 2 0 0 2 2 2 1 Doublesex-and mab-3-related transcription factor C1 and C2 DM PF00751.16 NM_001040283.2_3 - 3.1e-20 71.6 10.2 5.3e-20 70.9 10.2 1.4 1 0 0 1 1 1 1 DM DNA binding domain Peptidase_S24 PF00717.21 NM_001271922.1_2 - 2.6e-09 36.8 0.1 6e-09 35.6 0.1 1.6 2 0 0 2 2 2 1 Peptidase S24-like CpcD PF01383.19 NM_020178.4_1 - 0.081 13.1 0.2 0.17 12.1 0.2 1.5 1 0 0 1 1 1 0 CpcD/allophycocyanin linker domain Ribosomal_60s PF00428.17 NM_020178.4_1 - 0.24 11.9 3.2 0.42 11.1 3.2 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Carb_anhydrase PF00194.19 NM_020178.4_3 - 1.3e-65 221.3 0.1 2e-65 220.7 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Pkinase PF00069.23 NM_001313953.1_2 - 1.4e-55 188.4 0.0 1.8e-55 188.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001313953.1_2 - 8.5e-31 107.0 0.0 1.1e-30 106.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001313953.1_2 - 0.00045 19.5 0.0 0.00057 19.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001313953.1_2 - 0.13 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Collagen PF01391.16 NM_138455.3_2 - 1.6e-06 27.6 7.7 3.4e-06 26.6 7.7 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) bZIP_1 PF00170.19 NM_183012.1_1 - 1.3e-34 118.0 23.7 2.2e-18 66.0 13.1 2.5 2 0 0 2 2 2 2 bZIP transcription factor pKID PF02173.15 NM_183012.1_1 - 5.3e-19 67.3 1.1 5.3e-19 67.3 1.1 2.1 2 0 0 2 2 2 1 pKID domain bZIP_2 PF07716.13 NM_183012.1_1 - 4.6e-12 45.7 26.7 1.2e-06 28.3 13.6 2.4 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.15 NM_183012.1_1 - 0.0031 17.9 14.2 0.073 13.5 6.7 2.5 2 0 0 2 2 2 2 bZIP Maf transcription factor TPR_MLP1_2 PF07926.10 NM_183012.1_1 - 0.067 13.1 8.4 0.64 10.0 2.7 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein ASD2 PF08687.9 NM_183012.1_1 - 0.076 12.5 0.2 0.076 12.5 0.2 2.8 3 0 0 3 3 3 0 Apx/Shroom domain ASD2 DUF4988 PF16378.3 NM_183012.1_1 - 0.15 11.5 4.4 3.4 7.1 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function Nnf1 PF03980.12 NM_183012.1_1 - 1.4 9.2 12.0 6.7 7.0 4.5 2.6 2 0 0 2 2 2 0 Nnf1 HALZ PF02183.16 NM_183012.1_1 - 3.3 7.8 7.4 12 6.1 0.6 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper TSC22 PF01166.16 NM_183012.1_1 - 5.3 7.3 7.6 5 7.4 0.7 2.4 2 0 0 2 2 2 0 TSC-22/dip/bun family FGF PF00167.16 NM_001321945.1_2 - 1.2e-39 135.1 0.0 1.8e-39 134.6 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 NM_001321945.1_2 - 0.076 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Fascin domain DUF1640 PF07798.9 NM_001286116.1_2 - 1.4e-57 194.4 15.4 2.4e-57 193.6 15.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) JAKMIP_CC3 PF16034.3 NM_001286116.1_2 - 0.0013 18.6 9.2 0.002 18.0 9.2 1.1 1 0 0 1 1 1 1 JAKMIP CC3 domain PRKG1_interact PF15898.3 NM_032103.2_3 - 8.1e-35 119.7 20.6 8.1e-35 119.7 20.6 2.8 3 0 0 3 3 3 1 cGMP-dependent protein kinase interacting domain MIF4G PF02854.17 NM_080599.2_3 - 4.5e-79 264.9 11.3 1.1e-42 146.0 0.0 3.6 3 0 0 3 3 3 3 MIF4G domain Upf2 PF04050.12 NM_080599.2_3 - 1.7e-31 109.4 1.4 1.7e-31 109.4 1.4 4.8 3 2 1 4 4 4 1 Up-frameshift suppressor 2 Geminin PF07412.10 NM_001251991.1_2 - 2.8e-80 268.6 13.3 3.3e-80 268.4 13.3 1.0 1 0 0 1 1 1 1 Geminin Fmp27_WPPW PF10359.7 NM_001251991.1_2 - 0.0029 16.4 3.4 0.005 15.6 3.4 1.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF641 PF04859.10 NM_001251991.1_2 - 0.057 13.6 2.8 0.12 12.6 2.8 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) APC_N_CC PF16689.3 NM_001251991.1_2 - 0.069 13.1 2.8 0.14 12.1 2.8 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Aldedh PF00171.20 NM_001251991.1_2 - 0.17 10.2 0.5 0.23 9.8 0.5 1.1 1 0 0 1 1 1 0 Aldehyde dehydrogenase family DivIC PF04977.13 NM_001251991.1_2 - 0.17 11.5 8.4 0.16 11.6 5.3 2.2 2 0 0 2 2 2 0 Septum formation initiator FAM76 PF16046.3 NM_001251991.1_2 - 0.25 10.5 4.8 0.34 10.1 4.8 1.1 1 0 0 1 1 1 0 FAM76 protein PhoU PF01895.17 NM_001251991.1_2 - 0.27 11.6 4.7 0.52 10.7 4.4 1.7 1 1 0 1 1 1 0 PhoU domain CCDC-167 PF15188.4 NM_001251991.1_2 - 0.37 11.0 8.1 0.091 13.0 4.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 CCDC92 PF14916.4 NM_001251991.1_2 - 0.48 10.1 4.4 1.4 8.6 0.4 2.6 2 0 0 2 2 2 0 Coiled-coil domain of unknown function IncA PF04156.12 NM_001251991.1_2 - 3.5 7.2 6.6 6.8 6.3 6.6 1.4 1 0 0 1 1 1 0 IncA protein APG6 PF04111.10 NM_001251991.1_2 - 9.9 5.3 11.8 15 4.7 11.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Guanylate_kin PF00625.19 NM_001278373.1_1 - 5.9e-45 153.0 0.0 9.5e-45 152.4 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase L27 PF02828.14 NM_001278373.1_1 - 1.3e-28 98.3 4.5 1.8e-16 59.5 2.2 2.8 2 0 0 2 2 2 2 L27 domain SH3_2 PF07653.15 NM_001278373.1_1 - 4.9e-10 38.8 0.1 1.3e-09 37.4 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain PDZ PF00595.22 NM_001278373.1_1 - 5.2e-08 33.0 1.2 9.6e-08 32.2 0.6 1.8 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) SH3_1 PF00018.26 NM_001278373.1_1 - 4.9e-06 25.9 0.0 1.5e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 SH3 domain PDZ_2 PF13180.4 NM_001278373.1_1 - 0.00016 21.8 0.1 0.00031 20.9 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 NM_001278373.1_1 - 0.0015 18.4 0.0 0.01 15.7 0.1 2.3 2 1 0 2 2 2 1 Tricorn protease PDZ domain SH3_9 PF14604.4 NM_001278373.1_1 - 0.011 15.5 0.0 0.029 14.1 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain Glyco_transf_90 PF05686.10 NM_153705.4_1 - 9.2e-86 288.1 0.2 1.2e-85 287.7 0.2 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Filamin PF00630.17 NM_153705.4_1 - 9.5e-09 35.9 0.0 1.7e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Filamin/ABP280 repeat Glyco_trans_1_2 PF13524.4 NM_153705.4_1 - 0.11 12.8 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 Ets PF00178.20 NM_198381.1_3 - 2.6e-29 101.4 0.4 5.5e-29 100.3 0.4 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 NM_198381.1_3 - 2.9e-28 97.5 0.9 5.2e-28 96.7 0.9 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain IspD PF01128.17 NM_001101426.3_1 - 4.7e-39 134.3 0.0 6.6e-39 133.8 0.0 1.2 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NTP_transf_3 PF12804.5 NM_001101426.3_1 - 3.4e-08 33.9 0.1 6.5e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain ubiquitin PF00240.21 NM_001315505.1_1 - 0.072 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family Ank_2 PF12796.5 NM_001315505.1_3 - 6.8e-09 36.1 0.6 2.5e-05 24.6 0.5 3.1 2 2 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001315505.1_3 - 1.9e-08 34.5 0.6 3.9e-06 27.2 0.3 2.9 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001315505.1_3 - 0.083 13.2 0.4 23 5.4 0.1 3.6 3 1 1 4 4 4 0 Ankyrin repeats (many copies) NAD_binding_6 PF08030.10 NM_007052.4_3 - 2.2e-33 115.4 0.0 5.6e-33 114.1 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.17 NM_007052.4_3 - 4.4e-25 88.1 7.0 4.4e-25 88.1 7.0 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.10 NM_007052.4_3 - 1.1e-21 76.8 0.0 1.9e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.22 NM_007052.4_3 - 0.01 16.0 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.19 NM_007052.4_3 - 0.028 14.9 0.0 0.22 12.0 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain TGT PF01702.16 NM_024638.3_2 - 1.5e-65 221.0 0.0 2.4e-65 220.3 0.0 1.3 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase BSMAP PF12280.6 NM_001305052.1_2 - 3.9e-52 176.9 0.4 6.3e-52 176.3 0.4 1.3 1 0 0 1 1 1 1 Brain specific membrane anchored protein SPRY PF00622.26 NM_001159710.1_2 - 3.4e-15 56.1 0.0 7.5e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_001159710.1_2 - 3.8e-14 51.9 0.3 7e-14 51.0 0.3 1.5 1 0 0 1 1 1 1 SPRY-associated domain Urm1 PF09138.9 NM_001265582.1_1 - 0.0011 19.2 0.0 0.0018 18.4 0.0 1.2 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) Urm1 PF09138.9 NM_001265582.1_3 - 6.2e-19 68.0 0.0 7.4e-12 45.3 0.0 2.2 2 0 0 2 2 2 2 Urm1 (Ubiquitin related modifier) zf-C2H2 PF00096.24 NM_001300.5_1 - 1.8e-11 43.7 31.7 0.00053 20.2 8.9 4.2 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001300.5_1 - 1.6e-07 31.3 14.0 1.9e-05 24.7 6.6 3.6 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001300.5_1 - 0.00037 21.0 28.4 0.065 14.0 7.1 4.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.3 NM_001300.5_1 - 0.99 9.6 6.5 3.4 7.9 6.5 1.9 1 0 0 1 1 1 0 C2H2-type zinc ribbon Myosin_head PF00063.19 NM_005379.3_3 - 1.2e-266 886.1 0.4 1.6e-266 885.7 0.4 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 NM_005379.3_3 - 1.2e-44 152.1 0.0 2e-44 151.3 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 NM_005379.3_3 - 1.9e-08 33.2 18.1 7e-05 22.2 0.5 4.1 4 0 0 4 4 4 3 IQ calmodulin-binding motif AAA_16 PF13191.4 NM_005379.3_3 - 0.0047 17.2 0.0 0.014 15.6 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 NM_005379.3_3 - 0.016 15.4 0.1 0.067 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA PF00004.27 NM_001304419.1_1 - 3e-13 50.2 0.0 7.7e-13 48.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IQ PF00612.25 NM_001304419.1_1 - 4.8e-05 22.7 0.9 4.8e-05 22.7 0.9 2.3 2 0 0 2 2 2 1 IQ calmodulin-binding motif AAA_5 PF07728.12 NM_001304419.1_1 - 0.031 14.1 0.1 0.32 10.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 NM_001304419.1_1 - 0.094 13.0 0.3 1.2 9.3 0.1 2.9 2 1 0 2 2 2 0 AAA ATPase domain DUF4414 PF14377.4 NM_001304419.1_1 - 0.93 9.7 5.7 0.91 9.7 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4414) Senescence PF06911.10 NM_001142295.1_3 - 4.5e-52 176.7 3.6 6.9e-52 176.1 3.6 1.3 1 0 0 1 1 1 1 Senescence-associated protein MIT PF04212.16 NM_001142295.1_3 - 2.3e-06 27.5 0.1 4.7e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain B9-C2 PF07162.9 NM_001243473.2_2 - 2.1e-43 148.3 0.0 3e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein KH_1 PF00013.27 NM_001083963.1_2 - 1.3e-33 114.5 6.5 2.3e-16 59.3 0.6 2.3 2 0 0 2 2 2 2 KH domain TUDOR PF00567.22 NM_001083963.1_2 - 3.6e-30 104.4 0.0 4.3e-29 100.9 0.0 2.2 2 0 0 2 2 2 1 Tudor domain KH_2 PF07650.15 NM_001083963.1_2 - 2.9e-07 30.1 3.8 0.0051 16.5 0.4 2.5 2 0 0 2 2 2 2 KH domain KH_4 PF13083.4 NM_001083963.1_2 - 4.6e-06 26.3 0.8 0.017 14.8 0.0 2.6 2 0 0 2 2 2 2 KH domain KH_5 PF13184.4 NM_001083963.1_2 - 0.031 14.2 0.9 8.4 6.4 0.1 2.4 2 0 0 2 2 2 0 NusA-like KH domain Defensin_beta_2 PF13841.4 NM_001040705.1_2 - 2.2e-06 27.9 3.4 2.2e-06 27.9 3.4 1.9 2 0 0 2 2 2 1 Beta defensin Defensin_beta PF00711.17 NM_001040705.1_2 - 2.2 8.2 9.9 0.13 12.2 3.0 2.3 3 0 0 3 3 3 0 Beta defensin FAM110_N PF14161.4 NM_031424.5_3 - 9.8e-32 109.4 0.7 1.9e-31 108.4 0.7 1.4 1 0 0 1 1 1 1 Centrosome-associated N terminus FAM110_C PF14160.4 NM_031424.5_3 - 7.9e-31 107.3 0.0 1.1e-30 106.8 0.0 1.2 1 0 0 1 1 1 1 Centrosome-associated C terminus SH3_9 PF14604.4 NM_020870.3_3 - 2.6e-52 174.3 1.5 1.2e-14 53.7 0.0 4.4 4 0 0 4 4 4 4 Variant SH3 domain SH3_1 PF00018.26 NM_020870.3_3 - 1.5e-48 162.0 1.8 8.8e-12 44.3 0.0 4.4 4 0 0 4 4 4 4 SH3 domain SH3_2 PF07653.15 NM_020870.3_3 - 5.8e-34 115.4 2.1 5.9e-09 35.4 0.1 4.3 4 0 0 4 4 4 4 Variant SH3 domain zf-C3HC4 PF00097.23 NM_020870.3_3 - 1e-08 34.8 5.9 2.1e-08 33.7 5.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_020870.3_3 - 1.6e-08 34.1 6.7 3.4e-08 33.1 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_020870.3_3 - 1.9e-08 34.3 6.8 5.5e-08 32.8 6.8 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.4 NM_020870.3_3 - 2.2e-08 33.8 5.0 5e-08 32.7 5.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 NM_020870.3_3 - 1.5e-06 27.9 6.1 3.3e-06 26.8 6.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 NM_020870.3_3 - 0.00022 21.2 6.8 0.00056 19.9 6.8 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.4 NM_020870.3_3 - 0.00078 19.0 5.0 0.0022 17.6 5.0 1.8 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.4 NM_020870.3_3 - 0.0015 18.2 5.6 0.0066 16.2 5.8 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.3 NM_020870.3_3 - 0.018 14.6 3.0 0.045 13.4 3.0 1.7 1 0 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.6 NM_020870.3_3 - 0.18 11.5 1.6 0.44 10.3 1.6 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.18 NM_020870.3_3 - 0.46 10.2 4.6 1 9.0 4.6 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger DUF1356 PF07092.10 NM_024056.3_2 - 1.8e-100 334.8 3.7 2.5e-100 334.4 3.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Anti-TRAP PF15777.3 NM_024056.3_2 - 0.023 14.5 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein LEA_2 PF03168.11 NM_024056.3_2 - 0.05 14.0 0.2 0.084 13.2 0.2 1.3 1 0 0 1 1 1 0 Late embryogenesis abundant protein BTB PF00651.29 NM_001099270.1_2 - 3.8e-25 88.1 0.2 8.1e-25 87.1 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 NM_001099270.1_2 - 1.6e-09 37.6 35.4 0.0002 21.5 2.1 5.4 5 0 0 5 5 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001099270.1_2 - 2.9e-09 36.8 7.9 7.9e-07 29.1 0.6 5.3 5 0 0 5 5 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001099270.1_2 - 1.1e-05 25.7 33.9 0.002 18.6 0.3 6.2 6 0 0 6 6 4 3 C2H2-type zinc finger zf-met PF12874.5 NM_001099270.1_2 - 8.3e-05 22.7 14.1 0.016 15.4 0.3 4.3 4 0 0 4 4 4 2 Zinc-finger of C2H2 type DUF3342 PF11822.6 NM_001099270.1_2 - 8.6e-05 22.5 0.1 0.00019 21.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2_11 PF16622.3 NM_001099270.1_2 - 0.0002 20.9 10.3 0.028 14.1 0.2 3.9 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 NM_001099270.1_2 - 0.00095 19.3 6.5 1 9.6 0.4 4.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 NM_001099270.1_2 - 0.062 13.5 7.5 0.71 10.1 0.1 4.2 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.4 NM_001099270.1_2 - 0.66 9.9 9.2 4.6 7.2 0.3 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-BED PF02892.13 NM_001099270.1_2 - 0.84 9.6 20.0 1.1 9.2 0.7 4.0 2 1 2 4 4 3 0 BED zinc finger DUF4187 PF13821.4 NM_001099270.1_2 - 5.3 6.8 6.4 8.1 6.2 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4187) zf-H2C2_5 PF13909.4 NM_001099270.1_2 - 6.9 6.4 10.3 6 6.6 0.1 4.5 4 0 0 4 4 4 0 C2H2-type zinc-finger domain HSR PF03172.11 NM_000383.3_2 - 1.3e-24 86.0 0.0 1.9e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 HSR domain PHD PF00628.27 NM_000383.3_2 - 2.2e-14 52.9 21.4 2.9e-11 43.0 6.2 2.7 3 0 0 3 3 3 2 PHD-finger SAND PF01342.19 NM_000383.3_2 - 6.5e-06 25.6 0.0 1.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 SAND domain zf-HC5HC2H PF13771.4 NM_000383.3_2 - 0.0023 18.0 11.8 0.017 15.2 1.7 2.7 3 0 0 3 3 3 2 PHD-like zinc-binding domain PHD_2 PF13831.4 NM_000383.3_2 - 0.0071 15.7 11.3 0.068 12.6 1.9 2.6 2 0 0 2 2 2 2 PHD-finger zf-HC5HC2H_2 PF13832.4 NM_000383.3_2 - 0.04 14.0 11.9 0.27 11.3 3.1 2.6 2 0 0 2 2 2 0 PHD-zinc-finger like domain Prok-RING_1 PF14446.4 NM_000383.3_2 - 0.94 9.3 16.4 0.83 9.5 3.9 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-PHD-like PF15446.4 NM_000383.3_2 - 1.2 8.6 15.8 0.14 11.6 2.1 3.4 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain C1_2 PF03107.14 NM_000383.3_2 - 5.9 7.2 13.1 2.4 8.4 1.5 3.1 3 0 0 3 3 3 0 C1 domain MFS_1 PF07690.14 NM_001276326.1_1 - 2e-13 49.9 61.0 7.3e-09 34.9 28.6 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_001276326.1_1 - 7.1e-12 44.8 15.0 1.2e-08 34.2 10.7 2.8 1 1 2 3 3 3 3 Sugar (and other) transporter DUF3338 PF11819.6 NM_001318338.1_1 - 1.2e-58 196.8 5.3 1.2e-58 196.8 5.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3338) FERM_C PF09380.8 NM_001318338.1_1 - 6.8e-13 48.7 0.7 1.4e-12 47.7 0.7 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain INT_SG_DDX_CT_C PF15300.4 NM_012141.2_3 - 1.6e-26 91.7 3.6 3.4e-26 90.7 3.6 1.6 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus VWA_2 PF13519.4 NM_012141.2_3 - 5.6e-22 78.3 0.0 9.8e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 NM_012141.2_3 - 0.001 19.2 0.0 0.0017 18.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-FCS PF06467.12 NM_001142684.1_2 - 1.9e-24 85.2 38.5 9.6e-12 44.5 5.6 5.2 5 0 0 5 5 5 4 MYM-type Zinc finger with FCS sequence motif ATPase-cat_bd PF12156.6 NM_001142684.1_2 - 0.011 16.3 4.5 0.011 16.3 4.5 2.9 3 0 0 3 3 3 0 Putative metal-binding domain of cation transport ATPase YHS PF04945.11 NM_001142684.1_2 - 0.022 14.7 0.6 0.022 14.7 0.6 2.9 3 0 0 3 3 3 0 YHS domain zf-FLZ PF04570.12 NM_001142684.1_2 - 0.044 13.2 0.3 0.044 13.2 0.3 3.5 2 1 1 3 3 3 0 zinc-finger of the FCS-type, C2-C2 TROVE PF05731.9 NM_001173524.1_2 - 1.1e-96 324.1 3.6 3e-96 322.7 3.6 1.6 1 1 0 1 1 1 1 TROVE domain VWA_2 PF13519.4 NM_001173524.1_2 - 0.022 15.3 0.1 0.046 14.3 0.1 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain ZZ PF00569.15 NM_001320932.1_1 - 2.7e-09 36.6 10.5 5.5e-09 35.6 10.5 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_3 PF09069.9 NM_001320932.1_1 - 2e-07 31.2 0.3 4.4e-07 30.1 0.3 1.5 1 0 0 1 1 1 1 EF-hand C1_2 PF03107.14 NM_001320932.1_1 - 0.0034 17.5 10.7 0.0069 16.5 10.7 1.5 1 0 0 1 1 1 1 C1 domain DUF342 PF03961.11 NM_001320932.1_1 - 0.0047 15.5 2.4 0.0079 14.7 2.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF342) SOGA PF11365.6 NM_001320932.1_1 - 0.036 15.0 7.2 0.11 13.6 7.2 1.8 1 0 0 1 1 1 0 Protein SOGA DUF4407 PF14362.4 NM_001320932.1_1 - 0.056 12.6 0.3 0.095 11.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CRISPR_Cse2 PF09485.8 NM_001320932.1_1 - 0.49 10.8 8.1 0.89 9.9 7.7 1.5 1 1 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) APG6 PF04111.10 NM_001320932.1_1 - 0.84 8.8 7.7 1.5 8.0 7.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 NM_001320932.1_1 - 1.3 8.6 9.2 2.6 7.7 9.2 1.5 1 0 0 1 1 1 0 IncA protein MerR-DNA-bind PF09278.9 NM_001320932.1_1 - 2.4 8.6 11.8 2.7 8.5 10.0 2.1 1 1 0 1 1 1 0 MerR, DNA binding EF-hand_2 PF09068.9 NM_001320932.1_3 - 6.2e-35 119.9 1.6 8.1e-35 119.5 1.6 1.1 1 0 0 1 1 1 1 EF hand Spectrin PF00435.19 NM_016642.3_1 - 0 1066.2 357.4 1.1e-18 67.5 4.5 31.1 31 0 0 31 31 31 30 Spectrin repeat CH PF00307.29 NM_016642.3_1 - 2.6e-42 143.3 0.0 7.7e-21 74.2 0.0 3.1 2 0 0 2 2 2 2 Calponin homology (CH) domain PH PF00169.27 NM_016642.3_1 - 3.8e-05 24.0 0.0 0.00013 22.3 0.0 2.0 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 NM_016642.3_1 - 0.00082 19.6 0.0 0.0052 17.0 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain CAMSAP_CH PF11971.6 NM_016642.3_1 - 0.0013 18.3 0.0 0.026 14.2 0.0 2.7 2 0 0 2 2 2 1 CAMSAP CH domain IRF PF00605.15 NM_016642.3_1 - 0.51 10.5 4.3 1.4 9.1 0.0 3.6 3 0 0 3 3 3 0 Interferon regulatory factor transcription factor DUF948 PF06103.9 NM_016642.3_1 - 0.76 9.9 12.9 15 5.8 0.0 8.2 7 1 0 7 7 7 0 Bacterial protein of unknown function (DUF948) zf-ZPR1 PF03367.11 NM_016642.3_1 - 4.2 7.1 11.1 0.059 13.1 0.8 3.4 3 0 0 3 3 3 0 ZPR1 zinc-finger domain CT47 PF15623.4 NM_001080143.1_1 - 2.5e-116 388.3 31.1 3e-116 388.1 31.1 1.0 1 0 0 1 1 1 1 Cancer/testis gene family 47 AMP-binding PF00501.26 NM_001289177.1_3 - 4.2e-84 282.5 0.0 5.2e-84 282.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Cas_Cas2CT1978 PF09707.8 NM_001289177.1_3 - 0.0054 16.6 0.0 0.015 15.2 0.0 1.7 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Cas2CT1978) Ndr PF03096.12 NM_006096.3_1 - 3.2e-126 419.7 0.0 4e-126 419.3 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.18 NM_006096.3_1 - 0.014 14.9 0.0 0.076 12.5 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 NM_006096.3_1 - 0.033 13.3 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 adh_short PF00106.23 NM_148897.2_1 - 1.2e-38 132.4 0.0 1.5e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_148897.2_1 - 6e-25 88.0 0.0 8.4e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_148897.2_1 - 0.0055 16.5 0.0 0.0086 15.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Ig_3 PF13927.4 NM_001184881.1_2 - 1.6e-08 34.9 2.9 3.6e-05 24.1 1.9 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001184881.1_2 - 4.2e-06 26.7 3.4 0.25 11.4 0.0 3.4 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_001184881.1_2 - 0.0025 17.7 0.2 0.42 10.6 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001184881.1_2 - 0.0026 17.9 1.8 0.0056 16.9 1.8 1.6 1 0 0 1 1 1 1 Immunoglobulin domain zf-CCCH PF00642.22 NM_019103.2_3 - 7.7e-08 31.9 1.9 1.3e-07 31.2 1.9 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-U1 PF06220.10 NM_019103.2_3 - 4.9e-07 29.3 3.9 9.3e-07 28.4 3.9 1.5 1 0 0 1 1 1 1 U1 zinc finger zf-CCCH_2 PF14608.4 NM_019103.2_3 - 0.0056 17.0 2.3 0.011 16.1 2.3 1.5 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger zf-C2H2_jaz PF12171.6 NM_019103.2_3 - 3.2 8.0 6.8 10 6.4 6.8 1.9 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding dsrm PF00035.24 NM_003690.4_1 - 1.5e-31 108.7 0.3 4.6e-13 49.5 0.0 3.4 3 0 0 3 3 3 3 Double-stranded RNA binding motif Staufen_C PF16482.3 NM_003690.4_1 - 6.4e-09 35.8 0.4 6.8e-07 29.3 0.0 3.1 2 1 1 3 3 3 1 Staufen C-terminal domain DND1_DSRM PF14709.5 NM_003690.4_1 - 2.8e-07 30.6 1.6 0.0064 16.6 0.2 3.9 3 1 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 APO_RNA-bind PF05634.9 NM_003690.4_1 - 0.00094 18.5 0.0 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 APO RNA-binding zf-H2C2_2 PF13465.4 NM_001039886.3_1 - 1.1e-160 515.4 231.3 2.1e-09 37.2 1.6 27.6 28 0 0 28 28 28 24 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001039886.3_1 - 6.2e-101 325.5 255.5 1.1e-06 28.6 2.6 27.8 28 0 0 28 28 28 24 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001039886.3_1 - 8.8e-51 166.0 234.5 0.0038 17.8 1.1 26.6 27 0 0 27 27 26 23 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001039886.3_1 - 1.1e-20 73.0 207.5 0.00039 20.2 1.2 25.3 25 3 0 25 25 24 17 C2H2-type zinc finger KRAB PF01352.25 NM_001039886.3_1 - 4.4e-20 70.9 0.1 7.8e-20 70.2 0.1 1.4 1 0 0 1 1 1 1 KRAB box BolA PF01722.16 NM_001039886.3_1 - 8.1e-15 54.7 44.0 0.033 14.3 2.0 13.3 7 4 8 15 15 15 5 BolA-like protein Zn-ribbon_8 PF09723.8 NM_001039886.3_1 - 4.2e-14 52.2 138.1 0.01 15.8 2.7 19.6 9 7 15 24 24 24 15 Zinc ribbon domain zf-met PF12874.5 NM_001039886.3_1 - 9.3e-13 48.0 176.0 0.0012 19.0 1.0 22.1 22 0 0 22 22 22 10 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001039886.3_1 - 7.6e-10 38.7 133.2 0.021 15.0 0.4 22.3 22 0 0 22 22 22 6 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_001039886.3_1 - 9.6e-08 31.5 142.0 0.017 14.8 1.0 21.5 24 0 0 24 24 23 9 zinc-finger C2H2-type C1_1 PF00130.20 NM_001039886.3_1 - 4.7e-06 26.3 127.8 0.49 10.2 1.0 17.4 4 3 15 19 19 19 11 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_5 PF13909.4 NM_001039886.3_1 - 4.1e-05 23.1 5.8 0.00011 21.7 1.1 25.5 26 5 0 26 26 23 5 C2H2-type zinc-finger domain GATA PF00320.25 NM_001039886.3_1 - 0.017 14.6 0.4 0.017 14.6 0.4 12.0 12 2 1 13 13 11 0 GATA zinc finger HTH_18 PF12833.5 NM_001039886.3_1 - 0.05 13.7 1.1 79 3.5 0.1 5.0 4 1 1 5 5 5 0 Helix-turn-helix domain zinc_ribbon_15 PF17032.3 NM_001039886.3_1 - 1.2 9.8 129.3 1.2 9.8 2.4 13.1 3 2 10 13 13 13 0 zinc-ribbon family BHD_1 PF10403.7 NM_001039886.3_1 - 2 8.2 14.5 8 6.3 0.1 6.7 5 2 1 6 6 5 0 Rad4 beta-hairpin domain 1 zf-H2C2_2 PF13465.4 NM_001039886.3_2 - 1.3e-09 37.9 11.2 8.4e-06 25.9 0.9 3.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001039886.3_2 - 1.6e-07 31.3 17.5 0.00014 22.0 4.0 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001039886.3_2 - 0.0041 17.7 16.5 0.16 12.8 2.9 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001039886.3_2 - 0.016 14.9 6.8 0.48 10.1 0.3 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 NM_001039886.3_2 - 0.59 10.0 10.0 1.8 8.5 2.2 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001039886.3_2 - 1.4 9.0 4.1 12 6.0 4.6 2.1 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2 PF00096.24 NM_032153.5_1 - 4.4e-16 58.2 32.6 3.1e-05 24.0 0.2 6.0 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_032153.5_1 - 7e-14 51.4 30.7 3.4e-07 30.3 0.3 5.4 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_032153.5_1 - 1.2e-05 25.6 29.2 0.034 14.8 0.2 6.1 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_032153.5_1 - 0.079 12.6 2.1 0.28 10.9 2.1 2.0 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 NM_032153.5_1 - 7.2 6.9 11.6 1.3 9.3 0.0 4.0 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding PP1_bind PF15276.4 NM_001317906.1_3 - 3.3e-26 91.3 1.4 3.3e-26 91.3 1.4 3.2 3 0 0 3 3 3 1 Protein phosphatase 1 binding HECT PF00632.23 NM_199424.2_1 - 7.8e-99 330.9 0.3 9.7e-99 330.6 0.3 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 NM_199424.2_1 - 4.2e-22 77.7 9.3 1.8e-12 46.8 3.4 2.6 2 0 0 2 2 2 2 WW domain NCD2 PF04905.11 NM_005967.3_1 - 3.2e-57 192.8 0.0 5e-57 192.1 0.0 1.2 1 0 0 1 1 1 1 NAB conserved region 2 (NCD2) NCD1 PF04904.11 NM_005967.3_1 - 3e-41 139.1 0.0 4.8e-41 138.5 0.0 1.3 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) DnaJ_C PF01556.16 NM_012266.5_1 - 2.3e-41 141.2 0.0 3.2e-41 140.7 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 NM_012266.5_1 - 1.6e-28 98.4 2.5 2.6e-28 97.8 2.5 1.3 1 0 0 1 1 1 1 DnaJ domain tRNA_SAD PF07973.12 NM_025267.3_2 - 2.1e-09 37.2 0.2 5.5e-09 35.8 0.2 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.17 NM_025267.3_2 - 3.8e-06 25.6 0.0 5.7e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) TFIIA PF03153.11 NM_001198593.1_1 - 1.7e-94 318.0 4.8 3.2e-94 317.2 4.8 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Adap_comp_sub PF00928.19 NM_001198593.1_1 - 8.5e-64 215.3 0.4 1.5e-63 214.5 0.4 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Pkinase PF00069.23 NM_001284364.2_2 - 7.4e-73 245.0 0.0 9.8e-73 244.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001284364.2_2 - 1.4e-45 155.5 0.0 1.8e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.16 NM_001284364.2_2 - 6.6e-33 112.5 9.9 7.7e-19 67.4 1.2 2.6 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain Kdo PF06293.12 NM_001284364.2_2 - 0.00021 20.6 0.1 0.0004 19.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF572 PF04502.11 NM_001320566.1_1 - 4.5e-64 217.0 4.4 6.3e-64 216.5 4.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) ZZ PF00569.15 NM_001320566.1_1 - 1.4 8.7 3.9 7 6.4 0.3 2.4 2 0 0 2 2 2 0 Zinc finger, ZZ type DUF572 PF04502.11 NM_001320566.1_3 - 6.6e-27 94.8 3.2 9.9e-27 94.2 3.2 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF1580 PF07618.9 NM_001320566.1_3 - 0.053 13.0 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) VAD1-2 PF15310.4 NM_152343.2_1 - 2.8e-111 371.2 11.8 4.7e-111 370.5 11.8 1.3 1 0 0 1 1 1 1 Vitamin A-deficiency (VAD) rat model signalling ubiquitin PF00240.21 NM_001282906.1_1 - 8e-12 44.6 0.0 3e-07 30.0 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin family zf-AN1 PF01428.14 NM_001282906.1_1 - 5.7e-09 35.9 8.3 1.7e-08 34.4 8.3 1.9 1 0 0 1 1 1 1 AN1-like Zinc finger GN3L_Grn1 PF08701.9 NM_206826.1_1 - 2.2e-21 75.6 22.6 2.2e-21 75.6 22.6 3.9 4 0 0 4 4 4 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.21 NM_206826.1_1 - 3.9e-12 46.1 0.1 3.6e-10 39.8 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.16 NM_206826.1_1 - 3.2e-06 26.6 0.1 0.0029 17.0 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.14 NM_206826.1_1 - 5.3e-06 26.3 0.8 0.015 15.1 0.8 2.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_206826.1_1 - 0.00062 19.2 0.0 0.012 15.0 0.0 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain ArgK PF03308.14 NM_206826.1_1 - 0.0029 16.5 0.0 0.0072 15.2 0.0 1.6 1 0 0 1 1 1 1 ArgK protein NAD_binding_1 PF00175.19 NM_016243.2_3 - 3.1e-34 117.8 0.0 5.1e-34 117.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.22 NM_016243.2_3 - 3.7e-34 116.9 0.0 6.7e-34 116.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.10 NM_016243.2_3 - 5.6e-05 23.2 0.0 0.0054 16.7 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain PH PF00169.27 NM_001256787.1_1 - 1.5e-17 63.8 3.0 2.2e-17 63.4 0.1 2.8 3 0 0 3 3 3 1 PH domain PH_11 PF15413.4 NM_001256787.1_1 - 0.00024 21.4 2.3 0.002 18.4 2.3 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 NM_001256787.1_1 - 0.017 15.1 0.0 0.047 13.7 0.0 1.7 1 0 0 1 1 1 0 PH domain Trypsin_2 PF13365.4 NM_173555.3_2 - 6.8e-22 78.8 7.7 3.7e-19 69.9 4.3 2.3 2 0 0 2 2 2 2 Trypsin-like peptidase domain Trypsin PF00089.24 NM_173555.3_2 - 2.5e-07 30.6 0.3 4.5e-07 29.8 0.3 1.3 1 0 0 1 1 1 1 Trypsin 7tm_1 PF00001.19 NM_023915.3_2 - 2.4e-36 125.2 19.5 3.3e-36 124.8 19.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Alg14 PF08660.9 NM_023915.3_2 - 0.049 13.4 0.9 0.1 12.4 0.9 1.5 1 0 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like 7TM_GPCR_Srx PF10328.7 NM_023915.3_2 - 0.079 12.1 30.5 1.3 8.1 30.3 2.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx C2 PF00168.28 NM_001291901.1_1 - 4.1e-54 181.1 0.6 7.9e-27 93.4 0.0 2.3 2 0 0 2 2 2 2 C2 domain Comm PF15957.3 NM_001291901.1_1 - 0.012 15.8 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 Commissureless CEP76-C2 PF15627.4 NM_001291901.1_1 - 0.019 14.4 0.0 2.4 7.6 0.0 2.3 2 0 0 2 2 2 0 CEP76 C2 domain zf-H2C2_2 PF13465.4 NM_024620.3_1 - 3.8e-86 279.9 92.0 6.1e-09 35.8 2.1 14.7 15 0 0 15 15 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_024620.3_1 - 3.7e-72 234.8 88.0 1.6e-07 31.2 1.3 13.4 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_024620.3_1 - 7.4e-37 122.7 87.0 0.0047 17.5 1.5 13.5 13 0 0 13 13 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_024620.3_1 - 2.6e-22 78.1 71.1 0.018 14.9 0.2 12.8 12 0 0 12 12 12 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_024620.3_1 - 5.9e-15 55.0 59.8 0.0063 16.5 3.8 8.5 3 3 7 10 10 10 10 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_024620.3_1 - 1.4e-11 44.3 54.9 0.087 13.0 0.1 13.8 14 0 0 14 14 14 5 Zinc-finger double-stranded RNA-binding DZR PF12773.5 NM_024620.3_1 - 3.1e-06 27.0 50.5 1.6e+04 -27.2 50.5 7.0 1 1 0 1 1 0 0 Double zinc ribbon XPA_N PF01286.16 NM_024620.3_1 - 5.5e-06 26.2 57.3 0.58 10.1 0.1 12.3 13 0 0 13 13 13 4 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_024620.3_1 - 1.6e-05 25.5 42.9 1 10.1 0.8 6.6 1 1 4 6 6 6 6 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_024620.3_1 - 0.0059 16.2 47.9 1.4 8.6 1.8 10.8 11 0 0 11 11 11 3 zinc-finger C2H2-type HypA PF01155.17 NM_024620.3_1 - 0.038 13.9 41.2 1.5 8.7 5.5 6.8 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HC_2 PF13913.4 NM_024620.3_1 - 0.048 13.5 0.3 0.048 13.5 0.3 9.1 10 0 0 10 10 9 0 zinc-finger of a C2HC-type YhfH PF14149.4 NM_024620.3_1 - 1.6 8.7 49.6 13 5.7 0.2 11.5 11 0 0 11 11 11 0 YhfH-like protein C1_4 PF07975.10 NM_024620.3_1 - 2.1 8.6 51.9 5 7.3 2.2 8.1 1 1 9 10 10 10 0 TFIIH C1-like domain Filament PF00038.19 NM_153490.2_1 - 3.5e-119 397.9 33.8 4e-119 397.7 33.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 NM_153490.2_1 - 0.0014 18.5 2.3 0.0014 18.5 2.3 3.7 3 1 1 4 4 4 1 TPR/MLP1/MLP2-like protein RasGAP_C PF03836.13 NM_153490.2_1 - 0.23 11.5 17.0 0.099 12.7 0.9 3.4 1 1 1 3 3 3 0 RasGAP C-terminus DUF4686 PF15742.3 NM_153490.2_1 - 0.36 9.7 26.7 0.26 10.2 6.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4686) DUF4407 PF14362.4 NM_153490.2_1 - 1.1 8.4 16.5 0.74 9.0 8.1 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) SPATA1_C PF15743.3 NM_153490.2_1 - 2 8.4 23.9 0.3 11.0 0.4 3.8 1 1 1 3 3 3 0 Spermatogenesis-associated C-terminus FlaC_arch PF05377.9 NM_153490.2_1 - 2.2 8.6 15.8 3.3 8.0 0.7 4.1 4 0 0 4 4 3 0 Flagella accessory protein C (FlaC) GTP-bdg_M PF16360.3 NM_153490.2_1 - 2.4 8.7 9.0 12 6.4 3.0 3.1 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region Prefoldin PF02996.15 NM_153490.2_1 - 2.4 8.0 17.7 0.17 11.6 0.9 4.0 4 0 0 4 4 4 0 Prefoldin subunit Bacillus_HBL PF05791.9 NM_153490.2_1 - 3.3 7.3 10.8 0.96 9.0 2.5 3.0 1 1 3 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) Atg14 PF10186.7 NM_153490.2_1 - 7.4 5.4 18.5 4.3 6.2 12.6 2.6 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ASCH PF04266.12 NM_001171909.3_3 - 0.049 14.1 0.0 0.081 13.4 0.0 1.3 1 0 0 1 1 1 0 ASCH domain Kazal_1 PF00050.19 NM_001271721.1_2 - 2.4e-18 65.7 3.9 3.7e-18 65.1 3.9 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 NM_001271721.1_2 - 1.9e-09 37.5 1.6 2.9e-09 36.8 1.6 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain BORG_CEP PF14957.4 NM_006779.3_1 - 5.2e-21 75.8 5.6 7.3e-20 72.1 5.6 2.2 1 1 0 1 1 1 1 Cdc42 effector PBD PF00786.26 NM_006779.3_1 - 3.1e-09 37.0 0.0 5.1e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain CD20 PF04103.13 NM_152852.2_2 - 1.1e-31 109.9 12.0 1.5e-31 109.5 12.0 1.2 1 0 0 1 1 1 1 CD20-like family LRR_8 PF13855.4 NM_001278213.1_1 - 2.4e-12 46.3 0.5 1.9e-07 30.6 0.4 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 NM_001278213.1_1 - 3.5e-07 30.3 0.1 0.014 15.6 0.0 2.7 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001278213.1_1 - 0.005 17.0 0.7 97 4.0 0.0 4.8 3 1 1 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.4 NM_001278213.1_1 - 0.044 13.7 0.0 1.6 8.8 0.0 3.0 3 0 0 3 3 3 0 Leucine Rich repeat LRR_9 PF14580.4 NM_001278213.1_1 - 0.084 12.2 0.2 0.12 11.7 0.2 1.1 1 0 0 1 1 1 0 Leucine-rich repeat Amidase_2 PF01510.23 NM_005091.2_2 - 1.1e-18 67.8 0.0 1.6e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase MRG PF05712.11 NM_001142429.1_3 - 1.6e-52 177.6 0.4 2.1e-52 177.2 0.4 1.1 1 0 0 1 1 1 1 MRG AbLIM_anchor PF16182.3 NM_001114135.4_1 - 5.2e-86 289.7 14.9 1.5e-59 202.6 8.6 2.1 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 NM_001114135.4_1 - 1.2e-14 53.9 0.8 2.3e-14 53.0 0.8 1.5 1 0 0 1 1 1 1 Villin headpiece domain STAT1_TAZ2bind PF12162.6 NM_001114135.4_1 - 0.05 13.1 0.8 6.6 6.3 0.0 2.7 2 0 0 2 2 2 0 STAT1 TAZ2 binding domain zf-C2H2 PF00096.24 NM_031918.3_3 - 3.9e-13 48.9 22.8 5.8e-05 23.2 3.3 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_031918.3_3 - 2.1e-11 43.6 10.6 1e-06 28.8 3.4 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_031918.3_3 - 9.1e-06 26.0 20.2 0.002 18.7 2.2 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger FOXP-CC PF16159.3 NM_031918.3_3 - 0.13 12.8 7.3 2.1 8.9 0.8 3.0 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_8 PF15909.3 NM_031918.3_3 - 0.27 11.4 6.1 0.51 10.5 6.1 1.4 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-TRAF PF02176.16 NM_031918.3_3 - 1.1 9.9 4.1 0.34 11.5 1.0 1.7 1 1 1 2 2 2 0 TRAF-type zinc finger zf-Di19 PF05605.10 NM_031918.3_3 - 3.4 7.9 10.4 0.71 10.1 1.9 2.3 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 NM_031918.3_3 - 7.2 7.0 14.6 0.12 12.6 1.0 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type WD40 PF00400.30 NM_018383.4_2 - 2.5e-29 100.7 18.9 2.8e-06 27.8 0.0 7.7 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_018383.4_2 - 3.5e-10 39.9 1.7 0.65 10.2 0.1 5.3 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Collagen PF01391.16 NM_018383.4_2 - 1.4e-06 27.8 34.8 1.4e-06 27.8 34.8 9.6 6 1 2 8 8 8 2 Collagen triple helix repeat (20 copies) eIF2A PF08662.9 NM_018383.4_2 - 5.4e-05 23.0 3.2 0.081 12.7 0.7 2.8 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 NM_018383.4_2 - 0.002 17.0 0.1 0.019 13.8 0.1 2.2 1 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein BTB_2 PF02214.20 NM_138392.3_2 - 1.7e-22 79.5 0.0 3.2e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain WD40 PF00400.30 NM_138392.3_2 - 0.022 15.5 0.7 12 6.9 0.0 4.4 4 0 0 4 4 4 0 WD domain, G-beta repeat ISK_Channel PF02060.13 NM_005472.4_3 - 3.1e-06 26.8 0.0 6e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Slow voltage-gated potassium channel GSG-1 PF07803.9 NM_001323900.1_2 - 7.6e-44 148.2 0.0 2.2e-43 146.7 0.0 1.8 2 0 0 2 2 2 1 GSG1-like protein PMP22_Claudin PF00822.18 NM_001323900.1_2 - 5.4e-08 32.8 7.3 1.2e-07 31.6 7.3 1.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001323900.1_2 - 0.00053 19.7 8.3 0.0012 18.5 8.3 1.5 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction RRM_1 PF00076.20 NM_015062.4_1 - 2.4e-08 33.6 0.0 4.5e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Apt1 PF10351.7 NM_015062.4_1 - 1.1 8.0 20.0 2.3 6.8 20.0 1.5 1 0 0 1 1 1 0 Golgi-body localisation protein domain zf-C2H2 PF00096.24 NM_001324100.1_1 - 5.7e-09 35.8 13.1 0.00019 21.6 5.5 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001324100.1_1 - 1.3e-06 28.4 6.2 3.7e-06 27.0 1.8 3.2 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001324100.1_1 - 0.046 14.4 20.5 0.054 14.2 3.0 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger WD40 PF00400.30 NM_001322267.1_3 - 2e-37 126.4 15.0 3.2e-08 34.0 0.1 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat PRP4 PF08799.9 NM_001322267.1_3 - 5.4e-14 51.3 0.7 5.4e-14 51.3 0.7 1.8 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.5 NM_001322267.1_3 - 1e-09 38.4 0.0 0.017 15.3 0.0 4.8 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_001322267.1_3 - 0.00035 19.8 0.0 0.00092 18.5 0.0 1.6 2 0 0 2 2 2 1 WD40-like domain Arm_2 PF04826.11 NM_001286574.1_3 - 4.2e-22 78.7 0.4 6e-22 78.2 0.4 1.1 1 0 0 1 1 1 1 Armadillo-like HEAT_EZ PF13513.4 NM_001286574.1_3 - 7.7e-05 22.9 3.0 0.041 14.2 0.2 4.1 5 0 0 5 5 5 1 HEAT-like repeat Arm PF00514.21 NM_001286574.1_3 - 0.00036 20.3 1.0 0.76 9.8 0.1 3.8 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT PF02985.20 NM_001286574.1_3 - 0.009 16.0 0.4 6.6 7.1 0.0 3.5 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.4 NM_001286574.1_3 - 0.041 14.1 0.6 24 5.3 0.0 3.3 3 1 0 3 3 3 0 HEAT repeats V-ATPase_H_C PF11698.6 NM_001286574.1_3 - 0.047 13.7 0.1 0.84 9.6 0.0 2.4 2 0 0 2 2 2 0 V-ATPase subunit H Adaptin_N PF01602.18 NM_001286574.1_3 - 0.086 11.3 2.9 3.7 5.9 0.2 2.1 1 1 1 2 2 2 0 Adaptin N terminal region MRVI1 PF05781.10 NM_001100163.2_1 - 6.1e-212 704.9 5.6 8.2e-212 704.5 5.6 1.1 1 0 0 1 1 1 1 MRVI1 protein DUF3522 PF12036.6 NM_016446.3_3 - 1.2e-09 38.7 2.0 2.2e-09 37.9 2.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) Plasmod_Pvs28 PF06247.9 NM_016446.3_3 - 0.14 12.4 2.3 0.38 11.0 2.3 1.7 1 0 0 1 1 1 0 Pvs28 EGF domain Filament PF00038.19 NM_001300814.1_1 - 9.3e-83 278.2 32.4 1.2e-82 277.9 32.4 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 NM_001300814.1_1 - 0.018 15.0 31.5 0.3 11.0 4.5 2.7 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.7 NM_001300814.1_1 - 0.038 13.9 28.3 0.093 12.6 12.7 3.0 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF812 PF05667.9 NM_001300814.1_1 - 0.069 11.9 28.7 0.14 10.9 18.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) JIP_LZII PF16471.3 NM_001300814.1_1 - 0.1 12.7 14.5 1 9.5 0.6 4.0 4 1 0 4 4 3 0 JNK-interacting protein leucine zipper II CHASE9 PF17153.2 NM_001300814.1_1 - 0.12 12.4 0.7 0.29 11.2 0.6 1.6 1 1 0 1 1 1 0 Periplasmic sensor domain, extracellular DUF1664 PF07889.10 NM_001300814.1_1 - 0.27 11.1 9.7 5.9 6.8 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4200 PF13863.4 NM_001300814.1_1 - 0.29 11.4 29.8 0.023 14.9 6.8 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Baculo_PEP_C PF04513.10 NM_001300814.1_1 - 0.36 10.7 7.8 0.49 10.3 4.9 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.4 NM_001300814.1_1 - 0.39 9.9 24.5 0.063 12.5 10.8 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.9 NM_001300814.1_1 - 0.49 9.1 33.8 1.6 7.4 4.0 2.9 1 1 1 3 3 3 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 NM_001300814.1_1 - 0.59 9.3 6.0 2.2 7.5 2.2 2.5 1 1 1 3 3 3 0 Reovirus sigma C capsid protein FlaC_arch PF05377.9 NM_001300814.1_1 - 0.64 10.3 5.8 3.9 7.8 0.8 3.5 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) CLZ PF16526.3 NM_001300814.1_1 - 0.72 10.1 18.2 0.23 11.7 1.3 3.9 2 2 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ADIP PF11559.6 NM_001300814.1_1 - 0.95 9.4 23.4 0.013 15.5 11.1 2.5 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Seryl_tRNA_N PF02403.20 NM_001300814.1_1 - 1.8 8.7 15.5 3.4 7.8 9.3 2.5 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DivIC PF04977.13 NM_001300814.1_1 - 1.9 8.2 28.5 0.047 13.3 8.7 3.8 3 2 1 4 4 3 0 Septum formation initiator Alanine_zipper PF11839.6 NM_001300814.1_1 - 2.1 8.5 14.3 0.43 10.8 8.7 2.2 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein DMPK_coil PF08826.8 NM_001300814.1_1 - 2.3 8.3 21.5 1.3 9.0 2.1 4.7 3 1 1 4 4 4 0 DMPK coiled coil domain like IncA PF04156.12 NM_001300814.1_1 - 3 7.5 41.7 0.06 13.0 17.9 3.0 1 1 2 3 3 3 0 IncA protein HAUS-augmin3 PF14932.4 NM_001300814.1_1 - 3.5 6.9 33.0 0.67 9.3 19.0 2.7 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 DUF4140 PF13600.4 NM_001300814.1_1 - 4.5 7.7 20.3 1.6 9.1 0.4 3.5 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) LPP PF04728.11 NM_001300814.1_1 - 5 7.5 13.3 0.68 10.2 2.9 2.9 3 0 0 3 3 2 0 Lipoprotein leucine-zipper Syntaxin-6_N PF09177.9 NM_001300814.1_1 - 5 7.6 13.6 3.2 8.2 4.5 2.9 2 1 1 3 3 3 0 Syntaxin 6, N-terminal TRAF_BIRC3_bd PF16673.3 NM_001300814.1_1 - 6.3 6.5 7.0 2.6 7.8 1.7 2.8 3 0 0 3 3 2 0 TNF receptor-associated factor BIRC3 binding domain DUF2730 PF10805.6 NM_001300814.1_1 - 6.8 6.7 8.9 16 5.6 4.1 2.9 3 1 0 3 3 2 0 Protein of unknown function (DUF2730) APG6 PF04111.10 NM_001300814.1_1 - 7.1 5.8 32.4 0.73 9.0 5.8 2.6 1 1 1 2 2 2 0 Autophagy protein Apg6 Spc24 PF08286.9 NM_001300814.1_1 - 8.3 6.6 21.2 8.7 6.5 1.4 3.8 2 2 0 3 3 2 0 Spc24 subunit of Ndc80 MPC PF03650.11 NM_015415.3_3 - 2.3e-38 130.6 0.4 3.8e-38 129.9 0.4 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) Peptidase_C48 PF02902.17 NM_152699.4_1 - 7.3e-42 143.5 1.7 1.1e-41 142.9 1.7 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DEK_C PF08766.9 NM_152699.4_1 - 0.029 14.2 0.0 0.064 13.1 0.0 1.5 1 0 0 1 1 1 0 DEK C terminal domain TPD PF14811.4 NM_001130010.2_1 - 5.2e-53 178.4 0.0 1.5e-52 176.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function TPD sequence-motif zf-met PF12874.5 NM_001282725.1_2 - 1.4e-17 63.3 21.8 5.2e-07 29.7 1.8 4.2 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001282725.1_2 - 2e-15 56.5 14.5 4.6e-06 26.7 3.1 3.6 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 NM_001282725.1_2 - 3.1e-07 30.5 4.3 0.33 11.2 0.2 3.5 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.10 NM_001282725.1_2 - 2.6e-06 26.9 7.7 0.031 13.9 0.0 3.4 3 0 0 3 3 3 3 U1 zinc finger AKAP95 PF04988.10 NM_001282725.1_2 - 0.00032 20.8 6.2 0.47 10.5 0.3 3.4 3 0 0 3 3 3 2 A-kinase anchoring protein 95 (AKAP95) zf-DBF PF07535.10 NM_001282725.1_2 - 0.18 11.8 8.2 0.4 10.7 0.8 3.3 3 0 0 3 3 3 0 DBF zinc finger zf-C2H2 PF00096.24 NM_001282725.1_2 - 4.9 7.7 17.2 9.9 6.7 1.4 4.5 4 0 0 4 4 4 0 Zinc finger, C2H2 type AKAP95 PF04988.10 NM_014371.3_1 - 7.9e-74 247.2 7.6 1.3e-73 246.5 7.6 1.3 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) Actin_micro PF17003.3 NM_014371.3_1 - 0.63 9.0 12.7 0.44 9.5 3.8 2.1 1 1 1 2 2 2 0 Putative actin-like family zf-C2H2_2 PF12756.5 NM_014371.3_1 - 2.3 8.4 8.9 4.1 7.7 1.4 2.3 1 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 NM_014371.3_1 - 4.1 7.8 5.8 0.34 11.2 0.8 1.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PHD_4 PF16866.3 NM_001099784.2_3 - 2.9e-25 88.0 6.4 2.9e-25 88.0 6.4 1.9 2 0 0 2 2 1 1 PHD-finger zf-CXXC PF02008.18 NM_001099784.2_3 - 2e-13 50.0 21.7 2e-13 50.0 21.7 2.5 2 0 0 2 2 2 1 CXXC zinc finger domain F-box PF00646.31 NM_001099784.2_3 - 3.8e-09 36.1 2.5 3.8e-09 36.1 2.5 2.5 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.5 NM_001099784.2_3 - 2.3e-06 27.2 4.7 6.8e-06 25.7 4.7 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.5 NM_001099784.2_3 - 0.00032 20.9 0.8 0.79 10.1 0.1 3.1 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 NM_001099784.2_3 - 0.002 17.9 3.3 23 5.2 0.0 5.3 7 0 0 7 7 6 0 Leucine Rich repeat PHD PF00628.27 NM_001099784.2_3 - 0.003 17.3 5.6 0.003 17.3 5.6 2.4 2 0 0 2 2 1 1 PHD-finger LRR_8 PF13855.4 NM_001099784.2_3 - 0.014 15.0 2.6 7.3 6.3 0.0 3.2 3 0 0 3 3 3 0 Leucine rich repeat C1_1 PF00130.20 NM_001099784.2_3 - 0.047 13.4 0.2 0.047 13.4 0.2 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RbpA PF13397.4 NM_001099784.2_3 - 0.085 13.3 1.0 0.29 11.6 0.2 2.1 2 0 0 2 2 2 0 RNA polymerase-binding protein zf-4CXXC_R1 PF10497.7 NM_001099784.2_3 - 8 6.7 14.3 21 5.3 12.6 2.3 1 1 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Dynein_IC2 PF11540.6 NM_004411.4_2 - 1.2e-14 53.8 0.1 2.6e-14 52.7 0.1 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 NM_004411.4_2 - 3.7e-06 27.4 8.3 0.18 12.6 0.3 6.0 7 0 0 7 7 7 2 WD domain, G-beta repeat Xan_ur_permease PF00860.18 NM_005116.5_1 - 1.1e-88 297.5 21.6 1.5e-88 297.0 21.6 1.2 1 0 0 1 1 1 1 Permease family CAMSAP_CKK PF08683.9 NM_015447.3_1 - 1.6e-54 183.0 0.0 2.7e-54 182.3 0.0 1.4 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH PF11971.6 NM_015447.3_1 - 2.4e-34 116.9 0.2 5.2e-34 115.8 0.2 1.6 1 0 0 1 1 1 1 CAMSAP CH domain CAMSAP_CC1 PF17095.3 NM_015447.3_1 - 1e-25 89.2 3.5 1e-25 89.2 3.5 2.7 2 1 1 3 3 3 1 Spectrin-binding region of Ca2+-Calmodulin FlaC_arch PF05377.9 NM_182911.3_1 - 0.00021 21.5 2.1 0.00021 21.5 2.1 1.8 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) IncA PF04156.12 NM_182911.3_1 - 0.27 10.9 8.9 0.41 10.3 8.9 1.2 1 0 0 1 1 1 0 IncA protein Spc7 PF08317.9 NM_182911.3_1 - 0.3 9.8 9.4 0.39 9.4 9.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6 PF04111.10 NM_182911.3_1 - 2 7.6 11.2 2.7 7.2 11.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Cnn_1N PF07989.9 NM_182911.3_1 - 4.8 7.3 7.6 2.4 8.2 4.9 1.7 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 ERM PF00769.17 NM_182911.3_2 - 0.0045 16.7 21.2 0.0045 16.7 21.2 6.4 1 1 5 6 6 6 3 Ezrin/radixin/moesin family GAS PF13851.4 NM_182911.3_2 - 0.0064 15.8 4.6 0.0064 15.8 4.6 6.6 1 1 5 6 6 6 3 Growth-arrest specific micro-tubule binding DUF1664 PF07889.10 NM_182911.3_2 - 0.0077 16.1 6.5 0.0077 16.1 6.5 8.1 2 2 6 9 9 9 4 Protein of unknown function (DUF1664) Pox_A3L PF05288.9 NM_182911.3_2 - 0.3 11.0 9.1 0.11 12.4 0.2 3.7 3 0 0 3 3 3 0 Poxvirus A3L Protein KRAB PF01352.25 NM_001164529.1_1 - 2.8e-22 78.0 0.3 5.3e-22 77.1 0.3 1.5 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 NM_001164529.1_2 - 5.3e-131 421.6 127.8 2.6e-09 37.0 0.5 17.6 17 0 0 17 17 17 16 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001164529.1_2 - 8.9e-93 299.8 128.3 6.8e-07 29.3 1.8 16.7 16 0 0 16 16 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001164529.1_2 - 8e-47 153.7 121.4 0.0019 18.7 0.3 16.8 16 0 0 16 16 16 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001164529.1_2 - 2.4e-28 97.4 107.2 0.0085 15.9 0.2 16.8 16 0 0 16 16 16 15 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001164529.1_2 - 1.8e-18 66.2 84.8 0.0048 16.8 1.4 11.8 5 4 10 15 15 15 14 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001164529.1_2 - 5.3e-13 48.3 92.8 0.011 15.4 0.6 16.0 16 0 0 16 16 16 10 zinc-finger C2H2-type XPA_N PF01286.16 NM_001164529.1_2 - 1.3e-11 44.1 69.2 0.29 11.1 0.1 16.0 16 0 0 16 16 16 4 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001164529.1_2 - 1.7e-10 41.4 63.7 0.037 14.6 1.8 8.8 1 1 9 12 12 12 11 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_001164529.1_2 - 1.1e-09 38.3 77.1 0.56 10.4 1.3 15.6 16 0 0 16 16 16 6 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 NM_001164529.1_2 - 0.00017 21.2 58.3 1.8 8.4 0.0 14.3 13 3 0 13 13 13 1 Probable zinc-ribbon domain LIM_bind PF01803.14 NM_001164529.1_2 - 0.0072 15.7 0.0 19 4.5 0.0 3.7 3 1 0 4 4 4 0 LIM-domain binding protein HypA PF01155.17 NM_001164529.1_2 - 0.55 10.1 61.2 1.7 8.6 1.0 8.7 1 1 4 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_recom PF13408.4 NM_001164529.1_2 - 2.6 8.5 64.1 21 5.6 2.8 11.7 2 1 8 12 12 12 0 Recombinase zinc beta ribbon domain SPRY PF00622.26 NM_001159709.1_1 - 4.3e-15 55.7 0.0 9.1e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_001159709.1_1 - 4.4e-14 51.7 0.3 8.2e-14 50.8 0.3 1.5 1 0 0 1 1 1 1 SPRY-associated domain KAP_NTPase PF07693.12 NM_198478.3_1 - 4.2e-27 95.1 0.0 8.3e-27 94.1 0.0 1.5 1 1 0 1 1 1 1 KAP family P-loop domain 7tm_4 PF13853.4 NM_001005169.1_1 - 1.7e-76 257.5 17.7 2.1e-76 257.2 17.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005169.1_1 - 5.9e-14 51.8 20.8 1.6e-13 50.4 20.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001005169.1_1 - 1.2e-09 37.8 12.4 2e-09 37.1 12.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001005169.1_1 - 0.12 11.6 10.9 0.21 10.7 10.9 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx VGLL4 PF15245.4 NM_001284390.1_3 - 2.8e-86 288.9 3.9 4.7e-86 288.2 3.9 1.3 1 0 0 1 1 1 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.12 NM_001284390.1_3 - 0.00082 18.9 0.0 1.2 8.8 0.0 2.5 2 0 0 2 2 2 2 Vestigial/Tondu family Gly_acyl_tr_N PF06021.9 NM_001160138.1_3 - 0.2 11.6 3.6 16 5.4 2.1 2.6 2 0 0 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase DUF4590 PF15257.4 NM_001002912.4_1 - 7.1e-56 186.9 1.2 1.3e-55 186.1 1.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4590) DUF4542 PF15075.4 NM_001002912.4_1 - 0.055 13.7 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4542) Cmyb_C PF09316.8 NM_001161660.1_2 - 8.9e-70 233.5 2.5 1.5e-69 232.7 2.5 1.3 1 0 0 1 1 1 1 C-myb, C-terminal Myb_DNA-binding PF00249.29 NM_001161660.1_2 - 2.2e-54 181.3 18.2 1.2e-18 66.9 1.8 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 NM_001161660.1_2 - 1.1e-39 134.4 16.7 4.4e-17 61.9 2.0 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 NM_001161660.1_2 - 1.8e-10 40.5 5.1 0.00024 20.8 0.2 3.3 1 1 2 3 3 3 2 Myb DNA-binding like SLIDE PF09111.8 NM_001161660.1_2 - 7.4e-06 25.8 0.5 1.8 8.5 0.0 3.4 1 1 2 3 3 3 3 SLIDE SANT_DAMP1_like PF16282.3 NM_001161660.1_2 - 0.00049 20.1 3.6 0.58 10.3 0.0 3.3 1 1 2 3 3 3 1 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.6 NM_001161660.1_2 - 0.3 11.1 8.0 2.5 8.1 0.2 3.4 1 1 2 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain ZZ PF00569.15 NM_015113.3_2 - 5.6e-16 57.9 16.2 5.1e-08 32.5 5.6 2.7 2 0 0 2 2 2 2 Zinc finger, ZZ type ANAPC10 PF03256.14 NM_015113.3_2 - 1.6e-14 53.8 0.2 3e-14 53.0 0.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.23 NM_015113.3_2 - 0.00018 21.4 0.0 0.00042 20.3 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain EF-hand_6 PF13405.4 NM_015113.3_2 - 0.0014 18.3 0.0 0.0046 16.7 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain CUB PF00431.18 NM_015113.3_2 - 0.0014 18.8 2.4 0.27 11.5 0.1 3.0 3 0 0 3 3 3 2 CUB domain EF-hand_1 PF00036.30 NM_015113.3_2 - 0.0019 17.5 0.1 0.0051 16.1 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 NM_015113.3_2 - 0.045 13.4 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_7 PF13499.4 NM_015113.3_2 - 0.061 13.7 0.0 0.27 11.6 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.4 NM_015113.3_2 - 0.17 11.3 0.1 0.37 10.3 0.1 1.6 1 0 0 1 1 1 0 EF hand Tetraspannin PF00335.18 NM_001128309.1_3 - 4.7e-15 55.8 0.0 1.5e-14 54.2 0.0 1.8 1 1 0 1 1 1 1 Tetraspanin family Sema PF01403.17 NM_001324031.1_3 - 2.3e-150 500.9 0.0 2.9e-150 500.6 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 NM_001324031.1_3 - 5.7e-07 29.8 5.1 2.5e-06 27.8 5.1 2.2 1 0 0 1 1 1 1 Plexin repeat PSI_integrin PF17205.1 NM_001324031.1_3 - 1 9.1 7.1 6.1 6.6 4.6 2.7 2 0 0 2 2 2 0 Integrin plexin domain DPPIV_N PF00930.19 NM_001321913.1_1 - 2.7e-111 371.6 1.4 3.4e-111 371.3 1.4 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 NM_001321913.1_1 - 1.6e-46 158.3 0.0 2.3e-46 157.8 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.16 NM_001321913.1_1 - 5.8e-06 25.9 0.1 2.2e-05 24.0 0.1 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family PD40 PF07676.10 NM_001321913.1_1 - 0.022 14.6 0.3 4.9 7.1 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Abhydrolase_2 PF02230.14 NM_001321913.1_1 - 0.065 12.9 0.5 0.13 11.9 0.5 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.6 NM_001321913.1_1 - 0.19 10.8 0.2 7.6 5.6 0.1 2.1 1 1 1 2 2 2 0 Serine aminopeptidase, S33 Sortilin-Vps10 PF15902.3 NM_001206570.1_3 - 3.6e-106 355.5 0.0 4.5e-106 355.2 0.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.3 NM_001206570.1_3 - 2e-36 125.8 7.8 3.4e-36 125.0 7.8 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.18 NM_001206570.1_3 - 4.6e-09 35.9 3.6 7.7e-07 28.7 0.1 2.6 2 0 0 2 2 2 2 PKD domain BNR_6 PF15899.3 NM_001206570.1_3 - 0.09 12.8 0.9 2 8.6 0.0 3.2 3 0 0 3 3 3 0 BNR-Asp box repeat BNR PF02012.18 NM_001206570.1_3 - 1.5 9.0 13.7 8.1 6.8 0.5 5.5 5 0 0 5 5 5 0 BNR/Asp-box repeat OATP PF03137.18 NM_001145944.1_1 - 7.9e-161 535.9 12.7 1.2e-160 535.3 12.7 1.3 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 NM_001145944.1_1 - 3.4e-19 68.9 2.8 3.4e-19 68.9 2.8 3.7 4 0 0 4 4 4 3 Major Facilitator Superfamily Kazal_2 PF07648.13 NM_001145944.1_1 - 2.9e-10 40.1 4.2 2.9e-10 40.1 4.2 2.3 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 NM_001145944.1_1 - 0.014 15.2 8.9 0.052 13.4 8.9 2.0 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Det1 PF09737.7 NM_001144074.2_1 - 8.2e-194 644.2 0.9 1e-193 643.9 0.9 1.1 1 0 0 1 1 1 1 De-etiolated protein 1 Det1 Mito_carr PF00153.25 NM_002635.3_1 - 3.3e-48 161.4 7.4 8.6e-19 67.1 0.1 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein fn3 PF00041.19 NM_003999.2_1 - 1.3e-21 76.6 6.9 2.1e-05 24.7 0.0 5.9 6 0 0 6 6 6 4 Fibronectin type III domain EpoR_lig-bind PF09067.8 NM_003999.2_1 - 0.13 12.4 3.9 0.17 12.0 2.3 2.1 2 0 0 2 2 2 0 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.8 NM_003999.2_1 - 0.55 10.6 3.9 1.3 9.4 0.3 3.4 3 1 1 4 4 4 0 Interleukin-6 receptor alpha chain, binding SBF2 PF12335.6 NM_001286565.1_2 - 0.0024 17.4 1.3 0.0037 16.8 0.2 1.7 2 0 0 2 2 2 1 Myotubularin protein Proteasome PF00227.24 NM_144662.2_1 - 9.5e-59 197.9 0.7 1.3e-58 197.5 0.7 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 NM_144662.2_1 - 3.7e-14 51.9 0.2 8.9e-14 50.7 0.2 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GRASP55_65 PF04495.12 NM_031899.3_1 - 5.5e-74 246.9 0.0 2.5e-55 186.4 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.4 NM_031899.3_1 - 3.7e-08 33.4 0.0 2.8e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 PDZ domain HMG14_17 PF01101.16 NM_001318884.1_2 - 2.2e-25 89.3 22.2 3.4e-25 88.7 22.2 1.3 1 0 0 1 1 1 1 HMG14 and HMG17 PARM PF17061.3 NM_001318884.1_2 - 4.9 7.1 8.0 5.8 6.8 8.0 1.1 1 0 0 1 1 1 0 PARM TT_ORF2 PF02957.13 NM_001318884.1_2 - 5.8 7.7 6.2 13 6.6 6.2 1.5 1 0 0 1 1 1 0 TT viral ORF2 Roc PF08477.11 NM_022777.3_1 - 1.9e-13 50.6 0.0 2.8e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_022777.3_1 - 1.2e-09 37.9 0.0 1.7e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.19 NM_022777.3_1 - 4.1e-07 29.5 0.0 6.3e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 NM_022777.3_1 - 0.00012 21.4 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 NM_022777.3_1 - 0.015 14.4 0.0 0.94 8.4 0.0 2.4 2 1 1 3 3 3 0 G-protein alpha subunit Gtr1_RagA PF04670.10 NM_022777.3_1 - 0.022 14.0 0.0 0.032 13.5 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.7 NM_022777.3_1 - 0.09 12.4 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation IFT20 PF14931.4 NM_001267777.1_3 - 1.9e-40 137.6 6.2 2.4e-40 137.3 6.2 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 DUF737 PF05300.9 NM_001267777.1_3 - 0.021 15.1 2.3 0.027 14.7 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) CENP-B_dimeris PF09026.8 NM_001810.5_1 - 1.1e-57 192.4 9.9 1.1e-57 192.4 9.9 3.3 2 1 1 3 3 1 1 Centromere protein B dimerisation domain DDE_1 PF03184.17 NM_001810.5_1 - 5.1e-42 143.3 0.0 7.1e-42 142.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease CENP-B_N PF04218.11 NM_001810.5_1 - 2.9e-23 81.1 0.3 5.2e-23 80.3 0.3 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc5 PF03221.14 NM_001810.5_1 - 6.1e-16 58.1 0.0 1.1e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_24 PF13412.4 NM_001810.5_1 - 0.00011 21.6 0.1 0.00025 20.4 0.1 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.5 NM_001810.5_1 - 0.001 18.8 0.0 0.0039 16.9 0.0 2.0 1 0 0 1 1 1 1 MarR family HTH_23 PF13384.4 NM_001810.5_1 - 0.0016 18.0 0.0 0.016 14.9 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.4 NM_001810.5_1 - 0.0077 15.9 0.2 0.016 14.9 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.4 NM_001810.5_1 - 0.066 13.2 1.6 2.2 8.3 0.0 3.1 3 0 0 3 3 2 0 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.14 NM_001810.5_1 - 0.11 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Transposase BUD22 PF09073.8 NM_001810.5_1 - 0.33 10.1 37.6 0.59 9.3 37.6 1.3 1 0 0 1 1 1 0 BUD22 RNA_polI_A34 PF08208.9 NM_001810.5_1 - 1.2 9.1 17.6 0.077 13.0 9.1 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Plasmodium_Vir PF05795.9 NM_001810.5_1 - 4 6.6 6.5 6.7 5.9 6.5 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RRM_1 PF00076.20 NM_001207000.1_2 - 2.8e-32 110.2 0.1 2e-15 56.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001207000.1_2 - 8.2e-17 61.0 0.1 3.4e-09 36.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 NM_001207000.1_2 - 0.00023 20.9 0.0 0.053 13.4 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif CBFNT PF08143.9 NM_001207000.1_2 - 0.0043 18.3 0.5 0.0043 18.3 0.5 2.6 2 0 0 2 2 2 1 CBFNT (NUC161) domain RRM_3 PF08777.9 NM_001207000.1_2 - 0.037 13.9 0.1 0.61 10.0 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif FXR_C1 PF16096.3 NM_005087.3_1 - 1e-38 131.3 10.7 1e-38 131.3 10.7 2.0 2 0 0 2 2 2 1 Fragile X-related 1 protein C-terminal region 2 FXR_C3 PF16097.3 NM_005087.3_1 - 2e-28 98.7 3.7 4.5e-28 97.6 3.7 1.6 1 0 0 1 1 1 1 Fragile X-related 1 protein C-terminal region 3 FXMRP1_C_core PF12235.6 NM_005087.3_1 - 6.5e-27 94.7 39.2 4.1e-16 59.7 11.9 3.3 1 1 2 3 3 3 2 Fragile X-related 1 protein core C terminal KH_1 PF00013.27 NM_005087.3_1 - 2.8e-15 55.8 0.9 9.4e-09 34.8 0.5 2.4 2 0 0 2 2 2 2 KH domain Agenet PF05641.10 NM_005087.3_1 - 1.3e-14 54.3 0.5 2e-08 34.5 0.1 2.6 2 0 0 2 2 2 2 Agenet domain KH_2 PF07650.15 NM_005087.3_1 - 0.0066 16.1 0.5 0.82 9.4 0.0 2.4 2 0 0 2 2 2 1 KH domain Reprolysin PF01421.17 NM_033274.4_2 - 1.1e-64 217.9 0.0 1.7e-64 217.3 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_033274.4_2 - 7.9e-32 109.9 6.2 7.9e-32 109.9 6.2 3.3 3 0 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 NM_033274.4_2 - 1.3e-26 93.4 0.1 2.2e-26 92.6 0.1 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_033274.4_2 - 7.7e-21 75.0 1.9 1.4e-20 74.1 1.9 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 NM_033274.4_2 - 7.4e-20 71.4 29.9 7.4e-20 71.4 29.9 4.2 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.4 NM_033274.4_2 - 6.3e-13 49.2 0.2 1e-12 48.5 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_033274.4_2 - 1.5e-11 44.5 0.4 2.5e-11 43.7 0.4 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_033274.4_2 - 8.8e-08 31.9 2.4 1.8e-07 30.9 2.4 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Adeno_E3_CR2 PF02439.13 NM_033274.4_2 - 0.0014 18.2 0.2 0.0034 17.0 0.2 1.6 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 ADK PF00406.20 NM_001199852.1_1 - 9.2e-30 103.6 0.0 1e-16 61.2 0.0 2.2 1 1 1 2 2 2 2 Adenylate kinase ADK_lid PF05191.12 NM_001199852.1_1 - 1.3e-15 57.0 0.0 2.5e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.4 NM_001199852.1_1 - 7.9e-10 39.2 0.1 2.1e-08 34.6 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.4 NM_001199852.1_1 - 0.00049 20.5 0.0 0.001 19.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 NM_001199852.1_1 - 0.0064 16.5 0.0 0.012 15.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain Glyco_transf_6 PF03414.11 NM_001282632.1_1 - 2.1e-142 473.5 0.0 2.7e-142 473.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 6 Glyco_tranf_2_4 PF13704.4 NM_001282632.1_1 - 0.013 15.8 0.0 0.029 14.8 0.0 1.6 1 1 0 1 1 1 0 Glycosyl transferase family 2 EF-hand_1 PF00036.30 NM_001303048.1_2 - 4.6e-14 50.7 6.3 2.9e-07 29.4 1.6 4.5 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 NM_001303048.1_2 - 1.5e-12 47.6 6.6 1.9e-07 31.3 0.1 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_001303048.1_2 - 3.4e-11 42.0 6.9 1.8e-07 30.4 0.9 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 NM_001303048.1_2 - 2.5e-08 33.4 4.7 0.0037 16.9 0.2 3.6 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_11 PF08976.9 NM_001303048.1_2 - 1e-05 26.2 0.2 0.00018 22.2 0.1 2.3 1 1 1 2 2 2 1 EF-hand domain EF-hand_5 PF13202.4 NM_001303048.1_2 - 2.2e-05 23.6 3.2 3.8e-05 22.9 1.5 2.3 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.4 NM_001303048.1_2 - 0.0039 17.3 0.0 0.94 9.7 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain UPF0154 PF03672.11 NM_001303048.1_2 - 0.0046 16.8 0.0 3.4 7.6 0.0 3.1 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) GPHH PF16905.3 NM_001303048.1_2 - 0.0078 15.9 0.0 2.2 8.1 0.0 2.3 2 0 0 2 2 2 2 Voltage-dependent L-type calcium channel, IQ-associated SPARC_Ca_bdg PF10591.7 NM_001303048.1_2 - 0.035 14.3 0.6 0.073 13.3 0.6 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Treacle PF03546.12 NM_001008657.2_1 - 1.4e-243 809.5 259.5 3.1e-174 580.6 124.1 6.3 1 1 6 7 7 7 6 Treacher Collins syndrome protein Treacle Gal-3-0_sulfotr PF06990.9 NM_001008657.2_1 - 0.028 13.2 0.1 0.045 12.5 0.1 1.2 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase DUF1242 PF06842.10 NM_020141.3_3 - 2.3e-09 36.8 1.9 4.9e-09 35.7 1.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) RasGEF PF00617.17 NM_006105.5_1 - 6.3e-47 159.8 0.0 9.5e-47 159.2 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain cNMP_binding PF00027.27 NM_006105.5_1 - 1.2e-16 60.3 0.0 2.9e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain RasGEF_N PF00618.18 NM_006105.5_1 - 5.8e-16 58.5 0.0 1.1e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 RasGEF N-terminal motif DEP PF00610.19 NM_006105.5_1 - 1.8e-14 53.4 0.1 3.6e-14 52.4 0.1 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) TRAP_alpha PF03896.14 NM_003144.4_3 - 2.7e-119 397.4 0.1 3.5e-119 397.1 0.1 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit BAR PF03114.16 NM_020145.3_2 - 1.3e-67 227.9 4.1 1.8e-67 227.3 4.1 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 NM_020145.3_2 - 7.2e-10 38.4 0.1 2.9e-09 36.5 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 NM_020145.3_2 - 2.7e-06 26.8 0.0 7.4e-06 25.4 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.7 NM_020145.3_2 - 4.7e-06 25.8 0.6 1.2e-05 24.5 0.2 1.4 1 1 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking SH3_1 PF00018.26 NM_020145.3_2 - 5.1e-06 25.9 0.0 1.1e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.3 NM_020145.3_2 - 0.0022 17.6 1.5 0.61 9.6 0.0 2.2 1 1 0 2 2 2 2 BAR domain of APPL family IMD PF08397.9 NM_020145.3_2 - 0.03 13.6 0.0 0.047 12.9 0.0 1.2 1 0 0 1 1 1 0 IRSp53/MIM homology domain PLAC8 PF04749.15 NM_001130715.1_3 - 6.1e-14 52.7 21.8 1.1e-13 51.9 21.8 1.4 1 0 0 1 1 1 1 PLAC8 family Cadherin PF00028.15 NM_001318373.1_3 - 1.3e-100 329.9 11.4 3.1e-20 72.3 0.1 7.3 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.9 NM_001318373.1_3 - 8.7e-83 277.4 1.0 1.4e-82 276.8 1.0 1.3 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.10 NM_001318373.1_3 - 1.7e-18 66.1 0.0 3e-08 33.2 0.0 5.8 6 0 0 6 6 6 4 Cadherin-like Cadherin_3 PF16184.3 NM_001318373.1_3 - 2.4e-06 27.4 17.2 0.93 9.4 0.0 5.9 6 0 0 6 6 6 4 Cadherin-like He_PIG PF05345.10 NM_001318373.1_3 - 0.0014 18.6 4.0 1.7 8.8 0.0 4.9 4 0 0 4 4 4 1 Putative Ig domain EphA2_TM PF14575.4 NM_001318373.1_3 - 0.0078 16.9 0.3 0.026 15.2 0.3 1.9 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DUF1510 PF07423.9 NM_001318373.1_3 - 0.038 13.3 0.2 0.073 12.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) AP3D1 PF06375.9 NM_001318373.1_3 - 0.047 13.8 0.4 0.12 12.5 0.4 1.6 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4834 PF16118.3 NM_001318373.1_3 - 1.1 10.1 3.7 0.4 11.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ribosom_S12_S23 PF00164.23 NM_021107.1_3 - 7.5e-25 87.0 0.1 1.1e-24 86.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Alveol-reg_P311 PF11092.6 NM_001142476.1_2 - 1.4e-35 121.1 0.0 2.5e-35 120.3 0.0 1.4 1 0 0 1 1 1 1 Neuronal protein 3.1 (p311) Neur_chan_LBD PF02931.21 NM_001303035.1_2 - 7.1e-51 172.6 0.0 9.9e-51 172.1 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_001303035.1_2 - 1.1e-40 140.0 1.8 1.3e-31 110.4 1.0 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region HMG_box_2 PF09011.8 NM_002129.3_2 - 1.5e-42 143.9 16.0 1.1e-27 96.2 7.7 2.3 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.17 NM_002129.3_2 - 4.6e-42 142.2 14.3 6.4e-26 90.4 1.8 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_5 PF14887.4 NM_002129.3_2 - 0.2 11.5 13.9 0.74 9.7 3.9 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box 5 RNA_pol_3_Rpc31 PF11705.6 NM_002129.3_2 - 0.45 10.6 23.4 0.74 9.9 23.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Ets PF00178.20 NM_002129.3_2 - 0.8 10.1 3.7 8.1 6.9 0.4 2.3 2 0 0 2 2 2 0 Ets-domain Ribosomal_60s PF00428.17 NM_002129.3_2 - 5.9 7.4 19.5 13 6.3 19.5 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Transcrip_act PF04949.11 NM_152281.2_1 - 4.3e-07 29.8 18.6 4.3e-07 29.8 18.6 1.8 2 0 0 2 2 2 1 Transcriptional activator zf-H2C2_2 PF13465.4 NM_001161501.1_1 - 5e-109 352.2 222.1 8.5e-08 32.2 0.6 25.9 25 1 0 25 25 25 22 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001161501.1_1 - 2.3e-69 226.0 236.8 1.2e-05 25.3 4.4 25.1 27 0 0 27 27 27 21 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001161501.1_1 - 4.1e-28 95.5 217.4 0.022 15.4 0.6 24.7 25 0 0 25 25 25 17 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001161501.1_1 - 2e-18 65.7 178.4 0.00055 19.7 0.4 23.0 22 1 0 22 22 22 16 C2H2-type zinc finger BolA PF01722.16 NM_001161501.1_1 - 1.5e-06 28.3 45.0 0.049 13.8 0.2 11.1 8 4 5 13 13 13 5 BolA-like protein Zn-ribbon_8 PF09723.8 NM_001161501.1_1 - 6.3e-05 22.9 140.9 0.066 13.2 1.3 18.2 7 3 15 22 22 22 10 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001161501.1_1 - 0.00058 20.0 129.5 0.021 15.0 0.2 21.2 21 0 0 21 21 21 7 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001161501.1_1 - 0.01 16.1 0.8 0.01 16.1 0.8 20.4 20 1 1 21 21 21 0 Zinc-finger of C2H2 type C1_1 PF00130.20 NM_001161501.1_1 - 0.044 13.5 120.0 0.47 10.2 3.6 14.9 5 2 9 15 15 15 0 Phorbol esters/diacylglycerol binding domain (C1 domain) NUDIX PF00293.26 NM_198949.1_1 - 4.7e-15 55.6 0.0 7.2e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain 7tm_4 PF13853.4 NM_001004742.2_3 - 6.9e-50 170.2 19.7 8.2e-50 170.0 19.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004742.2_3 - 1.3e-22 80.2 17.4 2.2e-22 79.5 17.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2254 PF10011.7 NM_001004742.2_3 - 0.028 13.1 7.7 0.03 13.0 0.4 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) Aldo_ket_red PF00248.19 NM_001190906.1_1 - 4.1e-29 101.5 0.0 1.8e-13 50.2 0.0 2.2 2 0 0 2 2 2 2 Aldo/keto reductase family Sulfotransfer_1 PF00685.25 NM_001055.3_2 - 7.2e-84 281.3 0.1 8.6e-84 281.0 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_001055.3_2 - 5.5e-09 36.6 0.0 8.7e-05 22.9 0.1 2.3 1 1 1 2 2 2 2 Sulfotransferase family PAXNEB PF05625.9 NM_019040.4_3 - 1.4e-109 366.5 0.0 1.9e-109 366.1 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein IRF-3 PF10401.7 NM_004029.2_2 - 3e-47 160.6 0.0 4.2e-47 160.1 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 NM_004029.2_2 - 8.3e-38 128.8 0.0 1.5e-37 127.9 0.0 1.5 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor RPEL PF02755.13 NM_001322311.1_3 - 2.8e-31 106.1 30.0 3.9e-09 35.8 2.9 4.5 4 0 0 4 4 4 4 RPEL repeat Sod_Ni PF09055.9 NM_001322311.1_3 - 0.14 12.5 0.6 0.31 11.5 0.6 1.4 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase FAP PF07174.9 NM_001322311.1_3 - 0.71 9.1 3.8 1.3 8.3 3.8 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) BRICHOS PF04089.12 NM_021999.4_2 - 5.3e-20 71.2 0.0 8.6e-20 70.5 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain SH3_1 PF00018.26 NM_001243349.1_1 - 8.2e-57 188.5 0.7 1.9e-14 52.9 0.0 4.7 4 0 0 4 4 4 4 SH3 domain SH3_9 PF14604.4 NM_001243349.1_1 - 3.8e-51 170.6 1.0 5.9e-14 51.5 0.0 5.4 5 0 0 5 5 5 5 Variant SH3 domain SH3_2 PF07653.15 NM_001243349.1_1 - 3.1e-40 135.5 0.3 1.7e-09 37.1 0.2 5.4 5 0 0 5 5 5 4 Variant SH3 domain SPRY PF00622.26 NM_001324081.1_1 - 6.1e-19 68.2 0.1 2.1e-18 66.5 0.1 1.8 2 0 0 2 2 2 1 SPRY domain SOCS_box PF07525.14 NM_001324081.1_1 - 0.0021 18.2 1.4 0.0047 17.1 1.4 1.6 1 0 0 1 1 1 1 SOCS box RabGAP-TBC PF00566.16 NM_001286733.1_2 - 2.2e-29 102.6 0.0 3e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain 7tm_3 PF00003.20 NM_020752.2_1 - 1.1e-34 120.1 22.6 2e-34 119.3 22.6 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR EGF_3 PF12947.5 NM_020752.2_1 - 0.025 14.7 0.5 0.025 14.7 0.5 2.6 3 0 0 3 3 3 0 EGF domain DUF5089 PF17002.3 NM_130798.2_3 - 0.019 14.7 6.9 0.016 14.9 3.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5089) V-SNARE_C PF12352.6 NM_130798.2_3 - 0.027 14.6 6.7 0.089 13.0 1.8 2.8 2 1 1 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Spc7 PF08317.9 NM_130798.2_3 - 0.35 9.6 3.0 0.64 8.7 3.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Sec20 PF03908.11 NM_130798.2_3 - 0.97 9.3 5.0 0.32 10.8 1.6 2.0 2 0 0 2 2 2 0 Sec20 DUF1664 PF07889.10 NM_130798.2_3 - 2.2 8.2 6.2 0.79 9.6 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) RhoGAP PF00620.25 NM_016573.3_1 - 2.8e-49 166.7 0.0 6.4e-49 165.5 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain C1_1 PF00130.20 NM_016573.3_1 - 2.2e-05 24.1 7.2 4.6e-05 23.1 7.2 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_2 PF13465.4 NM_001319083.1_2 - 3e-91 296.0 130.8 5.1e-09 36.0 2.2 15.8 16 0 0 16 16 15 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001319083.1_2 - 7.3e-48 158.3 138.4 2.1e-05 24.6 1.2 15.1 15 0 0 15 15 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001319083.1_2 - 1.7e-42 140.3 129.0 0.00013 22.4 1.2 14.8 15 0 0 15 15 14 13 C2H2-type zinc finger KRAB PF01352.25 NM_001319083.1_2 - 1.4e-23 82.1 1.3 2.7e-23 81.2 1.3 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001319083.1_2 - 3e-23 81.4 69.5 0.0015 18.7 0.8 13.6 13 0 0 13 13 13 9 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_001319083.1_2 - 2.9e-19 68.4 73.3 0.11 12.1 2.1 13.7 13 0 0 13 13 13 9 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 NM_001319083.1_2 - 9.6e-19 67.1 67.2 0.0011 18.9 1.8 9.9 5 2 5 10 10 10 9 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001319083.1_2 - 9.5e-18 63.6 95.7 0.0037 17.1 1.9 13.7 13 0 0 13 13 13 10 C2H2-type zinc finger zf-trcl PF13451.4 NM_001319083.1_2 - 5.1e-14 51.7 59.1 0.21 11.4 0.1 12.7 11 2 0 11 11 11 6 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 NM_001319083.1_2 - 8.8e-09 35.9 65.1 0.0074 16.9 1.4 8.2 1 1 9 10 10 10 6 zinc-ribbon family XPA_N PF01286.16 NM_001319083.1_2 - 3.7e-06 26.7 54.7 2.1 8.3 0.2 12.6 13 0 0 13 13 13 3 XPA protein N-terminal C1_1 PF00130.20 NM_001319083.1_2 - 2.8e-05 23.8 71.9 0.15 11.8 1.9 11.3 1 1 12 13 13 12 10 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2321 PF10083.7 NM_001319083.1_2 - 0.0053 16.3 50.3 0.034 13.6 0.6 7.5 1 1 5 7 7 7 3 Uncharacterized protein conserved in bacteria (DUF2321) zf-C2HE PF16278.3 NM_001319083.1_2 - 0.0065 16.8 1.9 0.0065 16.8 1.9 13.1 2 1 9 11 11 10 2 C2HE / C2H2 / C2HC zinc-binding finger Desulfoferrod_N PF06397.10 NM_001319083.1_2 - 0.016 14.7 53.5 0.75 9.3 0.2 11.4 12 0 0 12 12 12 0 Desulfoferrodoxin, N-terminal domain DUF2256 PF10013.7 NM_001319083.1_2 - 0.025 14.6 51.9 5.4 7.1 0.2 11.9 13 0 0 13 13 12 0 Uncharacterized protein conserved in bacteria (DUF2256) TerY_C PF15616.4 NM_001319083.1_2 - 0.03 14.3 27.3 0.096 12.7 0.2 5.3 1 1 5 6 6 6 0 TerY-C metal binding domain DUF3268 PF11672.6 NM_001319083.1_2 - 0.49 10.6 45.2 0.41 10.9 0.9 7.3 3 1 0 7 7 7 0 zinc-finger-containing domain HTH_18 PF12833.5 NM_001319083.1_2 - 3.5 7.8 17.3 63 3.8 0.0 7.8 9 0 0 9 9 9 0 Helix-turn-helix domain ADK_lid PF05191.12 NM_001319083.1_2 - 5.3 7.0 43.5 2.1 8.3 1.5 7.6 7 1 0 7 7 7 0 Adenylate kinase, active site lid Katanin_con80 PF13925.4 NM_001319083.1_2 - 5.4 6.9 12.7 39 4.1 0.1 5.3 3 2 3 6 6 6 0 con80 domain of Katanin zf-DNA_Pol PF08996.8 NM_001319083.1_2 - 9.6 5.8 55.6 0.35 10.5 2.0 7.0 1 1 6 8 8 8 0 DNA Polymerase alpha zinc finger Period_C PF12114.6 NM_001289864.1_2 - 1.1e-35 122.9 4.6 1.1e-35 122.9 4.6 3.2 4 0 0 4 4 4 1 Period protein 2/3C-terminal region PAS_3 PF08447.10 NM_001289864.1_2 - 1.5e-13 50.7 0.0 3.5e-13 49.5 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.4 NM_001289864.1_2 - 1.2e-07 31.6 0.0 2.4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS PF00989.23 NM_001289864.1_2 - 1.7e-07 31.1 0.0 3.6e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 PAS fold DNA_Packaging PF11053.6 NM_001289864.1_2 - 0.17 11.6 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 Terminase DNA packaging enzyme Cation_efflux PF01545.19 NM_001321036.1_1 - 2.6e-20 72.9 3.5 3.5e-20 72.5 3.5 1.1 1 0 0 1 1 1 1 Cation efflux family RseC_MucC PF04246.10 NM_001321036.1_1 - 3.8 7.4 5.3 1.1 9.1 2.4 1.5 1 1 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Metallophos PF00149.26 NM_001142353.2_1 - 5.4e-37 128.2 0.0 7.7e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EMP70 PF02990.14 NM_014742.3_2 - 2.8e-206 686.0 13.8 3.7e-206 685.6 13.8 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 TPT PF03151.14 NM_001281459.1_2 - 1.4e-10 40.9 2.9 7.8e-08 31.9 0.1 2.1 1 1 1 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.18 NM_001281459.1_2 - 3.4e-06 27.1 19.9 2.1e-05 24.6 11.3 2.4 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.9 NM_001281459.1_2 - 5.8 5.9 11.5 41 3.1 11.3 1.9 1 1 1 2 2 2 0 UAA transporter family UQ_con PF00179.24 NM_182688.2_3 - 7.5e-45 151.9 0.0 1.2e-44 151.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PA26 PF04636.11 NM_001199933.1_3 - 6.2e-209 694.3 2.2 7.2e-209 694.0 2.2 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) CMD PF02627.18 NM_001199933.1_3 - 0.00075 19.4 0.0 0.0026 17.6 0.0 1.9 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family FAM27 PF15832.3 NM_018192.3_1 - 0.0068 16.8 1.6 0.018 15.5 1.6 1.6 1 0 0 1 1 1 1 FAM27 D and E protein family 2OG-FeII_Oxy_3 PF13640.4 NM_018192.3_2 - 7.8e-11 42.6 0.0 2.5e-10 41.0 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.18 NM_018192.3_2 - 6.9e-09 36.0 0.0 2.8e-08 34.0 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.15 NM_018192.3_2 - 1e-08 34.5 17.4 0.0068 16.3 1.3 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.26 NM_018192.3_2 - 4.3e-05 23.0 14.6 0.1 12.4 0.2 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_018192.3_2 - 7.8e-05 22.5 8.6 0.0018 18.2 0.2 3.6 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.4 NM_018192.3_2 - 0.0002 21.8 9.9 0.0049 17.4 1.7 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat YfiO PF13525.4 NM_018192.3_2 - 0.0029 17.2 10.9 5.3 6.6 0.2 4.1 4 0 0 4 4 4 3 Outer membrane lipoprotein TPR_14 PF13428.4 NM_018192.3_2 - 0.0042 17.6 8.9 10 7.1 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.4 NM_018192.3_2 - 0.0097 15.8 11.2 7.4 6.7 0.7 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_018192.3_2 - 0.13 12.7 3.1 42 4.6 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.4 NM_018192.3_2 - 0.28 11.4 8.6 4.5 7.5 0.8 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.4 NM_018192.3_2 - 0.47 10.5 10.4 2.2 8.4 0.8 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.4 NM_018192.3_2 - 1.5 9.1 8.0 29 5.1 0.3 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_018192.3_2 - 6.8 6.6 9.9 0.54 10.1 2.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2363 PF10155.7 NM_017546.4_2 - 1e-54 183.9 6.3 1.4e-54 183.4 6.3 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2363) Aldo_ket_red PF00248.19 NM_001199862.1_2 - 6e-71 238.8 0.0 7.4e-71 238.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Abhydrolase_1 PF00561.18 NM_001320126.1_2 - 1.3e-24 87.1 0.0 2.4e-24 86.3 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_001320126.1_2 - 7.9e-18 65.7 0.0 1.4e-17 64.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 NM_001320126.1_2 - 1.2e-15 57.4 0.0 2.3e-15 56.4 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 NM_001320126.1_2 - 1.9e-05 23.4 0.1 5.1e-05 22.0 0.1 1.6 1 1 0 1 1 1 1 Ndr family BAAT_C PF08840.9 NM_001320126.1_2 - 0.01 15.7 0.0 0.039 13.8 0.0 1.8 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1057 PF06342.10 NM_001320126.1_2 - 0.011 14.6 0.0 0.017 14.0 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) FSH1 PF03959.11 NM_001320126.1_2 - 0.017 14.7 0.1 1 8.8 0.0 2.4 2 1 0 2 2 2 0 Serine hydrolase (FSH1) DLH PF01738.16 NM_001320126.1_2 - 0.025 14.0 0.0 0.4 10.1 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Rap_GAP PF02145.13 NM_001286779.1_1 - 5.5e-69 231.3 0.1 9.6e-69 230.5 0.1 1.4 1 0 0 1 1 1 1 Rap/ran-GAP CNH PF00780.20 NM_001286779.1_1 - 1.4e-68 231.3 0.0 2.2e-68 230.7 0.0 1.3 1 0 0 1 1 1 1 CNH domain ECH_1 PF00378.18 NM_001198962.1_3 - 2.7e-30 105.4 0.3 1.5e-13 50.5 0.0 3.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 NM_001198962.1_3 - 2.3e-15 56.8 0.3 3.9e-08 33.1 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Hyccin PF09790.7 NM_001321622.1_2 - 1.2e-116 389.2 0.1 1.7e-116 388.7 0.1 1.2 1 0 0 1 1 1 1 Hyccin Asp-B-Hydro_N PF05279.9 NM_001164755.1_3 - 3.8e-91 305.4 19.7 2.3e-71 240.5 1.7 2.1 1 1 1 2 2 2 2 Aspartyl beta-hydroxylase N-terminal region ATG27 PF09451.8 NM_001164755.1_3 - 0.03 14.0 0.1 0.049 13.3 0.1 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 SR-25 PF10500.7 NM_001164755.1_3 - 0.14 11.6 6.3 0.24 10.9 6.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GET2 PF08690.8 NM_001164755.1_3 - 2.3 7.6 5.5 3.9 6.9 5.5 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 CBFD_NFYB_HMF PF00808.21 NM_017443.4_3 - 1.9e-12 47.1 0.1 3.4e-12 46.3 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.4 NM_017443.4_3 - 0.0074 16.3 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.22 NM_017443.4_3 - 0.011 15.9 0.0 0.011 15.9 0.0 2.2 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Afi1 PF07792.10 NM_017443.4_3 - 0.042 14.2 5.7 0.081 13.3 5.7 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4746 PF15928.3 NM_017443.4_3 - 0.33 10.2 11.1 0.47 9.7 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Mtc1 PF10310.7 NM_017443.4_3 - 0.75 8.6 14.2 1.1 8.0 14.2 1.1 1 0 0 1 1 1 0 Maintenance of telomere capping protein 1 DDHD PF02862.15 NM_017443.4_3 - 1.2 9.1 4.3 1.7 8.6 4.3 1.1 1 0 0 1 1 1 0 DDHD domain Pox_Ag35 PF03286.12 NM_017443.4_3 - 5.3 6.7 15.4 7.9 6.1 15.4 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF1510 PF07423.9 NM_017443.4_3 - 9.8 5.4 19.2 14 4.9 19.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Y_phosphatase PF00102.25 NM_001206838.1_3 - 7.5e-145 480.5 4.3 1.5e-85 286.4 0.9 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Carb_anhydrase PF00194.19 NM_001206838.1_3 - 7.2e-72 241.8 0.1 1.1e-71 241.2 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase fn3 PF00041.19 NM_001206838.1_3 - 7.1e-13 48.6 0.1 3.2e-12 46.5 0.0 2.2 2 0 0 2 2 2 1 Fibronectin type III domain DSPc PF00782.18 NM_001206838.1_3 - 0.00034 20.3 0.1 0.018 14.8 0.0 2.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_001206838.1_3 - 0.004 17.0 0.0 0.0092 15.8 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family Peptidase_C10 PF01640.15 NM_001206838.1_3 - 0.03 14.5 0.4 0.086 13.0 0.1 1.9 2 0 0 2 2 2 0 Peptidase C10 family DUF912 PF06024.10 NM_001206838.1_3 - 0.06 13.5 0.1 0.23 11.6 0.1 2.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PTPlike_phytase PF14566.4 NM_001206838.1_3 - 0.1 12.6 0.1 0.43 10.6 0.0 2.1 2 0 0 2 2 2 0 Inositol hexakisphosphate Aldedh PF00171.20 NM_001161504.1_2 - 1.3e-103 346.8 0.0 1.6e-103 346.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RRM_1 PF00076.20 NM_001280.2_3 - 2.6e-25 87.9 0.1 4.1e-25 87.2 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001280.2_3 - 0.00063 19.7 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.3 NM_001280.2_3 - 0.0027 17.4 0.0 0.0051 16.5 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.4 NM_001280.2_3 - 0.16 11.4 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_8 PF13855.4 NM_001289135.2_1 - 6.4e-102 333.2 62.4 1.6e-14 53.3 2.3 10.8 4 4 5 10 10 10 10 Leucine rich repeat EGF PF00008.25 NM_001289135.2_1 - 2.9e-37 126.4 145.2 9.6e-08 32.1 8.1 11.6 11 0 0 11 11 11 9 EGF-like domain LRR_4 PF12799.5 NM_001289135.2_1 - 4.5e-35 118.8 65.9 2.1e-05 24.6 0.4 12.4 9 2 5 15 15 15 12 Leucine Rich repeats (2 copies) Laminin_G_1 PF00054.21 NM_001289135.2_1 - 9.2e-27 93.7 0.0 1.4e-26 93.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.22 NM_001289135.2_1 - 1.2e-23 83.9 0.0 1.9e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain LRR_9 PF14580.4 NM_001289135.2_1 - 2e-23 82.7 26.1 8.6e-07 28.5 0.5 5.4 4 1 1 5 5 5 5 Leucine-rich repeat LRRNT PF01462.16 NM_001289135.2_1 - 2.9e-20 71.3 63.2 3.5e-07 29.6 2.7 8.1 8 0 0 8 8 8 4 Leucine rich repeat N-terminal domain hEGF PF12661.5 NM_001289135.2_1 - 1.6e-15 56.9 138.0 7.5e-06 26.3 5.9 13.0 13 0 0 13 13 13 8 Human growth factor-like EGF LRRCT PF01463.22 NM_001289135.2_1 - 5.3e-14 51.4 14.5 0.0061 16.9 0.1 6.5 6 0 0 6 6 6 4 Leucine rich repeat C-terminal domain LRR_1 PF00560.31 NM_001289135.2_1 - 1.9e-06 27.4 35.4 1.6 9.3 0.2 13.3 12 1 0 12 12 12 2 Leucine Rich Repeat RhoGEF PF00621.18 NM_005369.4_3 - 3.5e-40 138.0 2.1 3.5e-40 138.0 2.1 3.2 3 1 0 3 3 3 1 RhoGEF domain CRAL_TRIO_2 PF13716.4 NM_005369.4_3 - 1.8e-07 31.2 0.0 6.4e-07 29.4 0.0 2.0 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PH PF00169.27 NM_005369.4_3 - 1.7e-06 28.3 0.2 1.7e-06 28.3 0.2 2.0 2 0 0 2 2 2 1 PH domain Cob_adeno_trans PF01923.16 NM_005369.4_3 - 8.8 6.3 7.2 1 9.4 0.3 2.7 3 0 0 3 3 3 0 Cobalamin adenosyltransferase Phtf-FEM1B_bdg PF12129.6 NM_006608.2_3 - 3.8e-69 231.3 3.3 8.5e-69 230.1 3.3 1.6 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor Phosphodiest PF01663.20 NM_001289053.1_2 - 7.8e-11 42.0 0.1 6.3e-07 29.2 0.0 2.1 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.16 NM_001289053.1_2 - 0.0068 15.7 0.0 0.0097 15.1 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily IRK PF01007.18 NM_001260510.1_1 - 1.7e-82 276.9 0.7 2.1e-82 276.6 0.7 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_001260510.1_1 - 1 9.2 11.0 4.5 7.2 11.0 2.0 1 1 0 1 1 1 0 Ion channel DAP10 PF07213.9 NM_001173514.1_1 - 0.02 14.7 3.5 0.032 14.1 3.5 1.3 1 0 0 1 1 1 0 DAP10 membrane protein IncA PF04156.12 NM_001173514.1_1 - 0.068 12.8 0.0 0.08 12.6 0.0 1.1 1 0 0 1 1 1 0 IncA protein V-ATPase_G PF03179.13 NM_001204078.1_2 - 2.3e-14 53.7 10.3 9.9e-11 42.0 8.0 2.1 1 1 1 2 2 2 2 Vacuolar (H+)-ATPase G subunit OmpH PF03938.12 NM_001204078.1_2 - 2 8.2 9.3 2.9 7.8 9.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Septin PF00735.16 NM_001306147.1_3 - 9.9e-98 326.7 1.2 1.7e-97 326.0 1.2 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 NM_001306147.1_3 - 2.7e-06 27.3 0.0 6.3e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.11 NM_001306147.1_3 - 0.0042 17.2 0.0 0.0084 16.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_001306147.1_3 - 0.0066 16.7 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF3080 PF11279.6 NM_001306147.1_3 - 0.0091 15.1 6.4 0.018 14.1 6.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3080) AAA_22 PF13401.4 NM_001306147.1_3 - 0.0093 16.1 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Ras PF00071.20 NM_001306147.1_3 - 0.027 13.9 0.0 0.048 13.1 0.0 1.4 1 0 0 1 1 1 0 Ras family DUF258 PF03193.14 NM_001306147.1_3 - 0.051 13.4 0.1 1.3 8.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_29 PF13555.4 NM_001306147.1_3 - 0.076 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.4 NM_001306147.1_3 - 0.11 12.9 19.5 0.84 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.25 NM_001306147.1_3 - 3.9 6.8 8.4 7.8 5.9 0.2 2.8 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Fzo_mitofusin PF04799.11 NM_001306147.1_3 - 6 6.2 9.2 11 5.4 9.2 1.3 1 0 0 1 1 1 0 fzo-like conserved region DUF2465 PF10239.7 NM_001304538.1_1 - 2e-30 106.0 0.3 2.6e-30 105.6 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) DUF2465 PF10239.7 NM_001304538.1_2 - 8.3e-75 251.9 0.3 1.1e-74 251.4 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) zf-C2H2 PF00096.24 NM_022893.3_1 - 1.5e-24 84.9 55.5 1.2e-05 25.4 2.8 7.7 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_022893.3_1 - 3.9e-13 49.1 55.8 6.6e-07 29.4 1.2 9.5 9 0 0 9 9 9 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_022893.3_1 - 1.4e-09 37.8 64.8 0.0044 17.6 1.3 8.8 9 0 0 9 9 7 6 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_022893.3_1 - 1e-07 31.5 22.8 0.0002 20.9 3.9 4.3 3 0 0 3 3 3 2 C2H2-type zinc-finger domain DUF3268 PF11672.6 NM_022893.3_1 - 0.003 17.8 15.2 0.025 14.8 1.3 2.5 2 0 0 2 2 2 2 zinc-finger-containing domain BSP_II PF05432.9 NM_022893.3_1 - 0.016 14.8 5.9 0.025 14.2 5.9 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Astro_capsid_p PF12226.6 NM_022893.3_1 - 0.19 10.7 5.4 0.3 10.1 5.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein GAGA PF09237.9 NM_022893.3_1 - 0.25 11.0 6.0 5.9 6.6 0.3 2.8 2 0 0 2 2 2 0 GAGA factor RNA_pol_3_Rpc31 PF11705.6 NM_022893.3_1 - 0.34 11.0 8.7 0.66 10.0 8.7 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Ribosomal_60s PF00428.17 NM_022893.3_1 - 2.3 8.7 10.9 4.8 7.7 10.9 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein zf-C2H2_11 PF16622.3 NM_022893.3_1 - 3.6 7.3 18.0 0.52 10.0 0.1 4.9 4 0 0 4 4 4 0 zinc-finger C2H2-type FAM176 PF14851.4 NM_022893.3_1 - 6.3 6.3 6.4 15 5.1 6.4 1.6 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.11 NM_022893.3_1 - 7.7 4.4 9.7 11 3.8 9.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi DEAD PF00270.27 NM_001111322.1_2 - 6.9e-50 169.1 0.0 1.5e-49 168.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001111322.1_2 - 2.3e-20 72.9 0.0 4.7e-19 68.7 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.10 NM_001111322.1_2 - 2.3e-18 66.1 8.7 6.2e-18 64.7 8.7 1.8 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.13 NM_001111322.1_2 - 1.7e-06 28.1 0.0 3.4e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit EPO_TPO PF00758.16 NM_001177598.2_1 - 8.5e-34 116.8 0.0 1.4e-33 116.1 0.0 1.3 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin EPO_TPO PF00758.16 NM_001177598.2_2 - 7.5e-07 29.2 0.2 1.9e-06 27.9 0.0 1.6 1 1 1 2 2 2 1 Erythropoietin/thrombopoietin ETS_PEA3_N PF04621.11 NM_001261437.1_3 - 5.9e-105 351.8 7.3 1.3e-104 350.7 7.3 1.5 1 1 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain Ets PF00178.20 NM_001261437.1_3 - 2.6e-38 130.2 0.1 4.4e-38 129.5 0.1 1.4 1 0 0 1 1 1 1 Ets-domain NAD_binding_8 PF13450.4 NM_018363.3_1 - 3.9e-15 55.7 0.0 7.4e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.22 NM_018363.3_1 - 1.3e-10 41.1 0.0 3.9e-10 39.5 0.0 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.12 NM_018363.3_1 - 0.0001 21.5 0.1 0.0012 18.0 0.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 NM_018363.3_1 - 0.00019 21.0 0.0 0.068 12.7 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.4 NM_018363.3_1 - 0.00045 20.1 0.0 0.0053 16.7 0.0 2.1 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox PF00070.25 NM_018363.3_1 - 0.021 15.2 0.1 1.6 9.2 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.17 NM_018363.3_1 - 0.051 12.7 0.5 0.081 12.0 0.5 1.2 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.18 NM_018363.3_1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.14 NM_018363.3_1 - 0.19 11.2 0.1 5.7 6.4 0.1 2.2 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA DNMT1-RFD PF12047.6 NM_001130823.2_3 - 8.5e-48 161.9 0.0 1.5e-46 157.9 0.0 2.6 2 0 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain DNA_methylase PF00145.15 NM_001130823.2_3 - 3.7e-47 161.1 0.0 3.7e-47 161.1 0.0 3.1 2 2 0 2 2 2 1 C-5 cytosine-specific DNA methylase BAH PF01426.16 NM_001130823.2_3 - 6.2e-46 155.1 0.0 1.1e-21 76.8 0.0 2.6 2 0 0 2 2 2 2 BAH domain DMAP_binding PF06464.9 NM_001130823.2_3 - 9.2e-21 74.6 2.9 9.2e-21 74.6 2.9 3.5 2 1 1 3 3 3 1 DMAP1-binding Domain zf-CXXC PF02008.18 NM_001130823.2_3 - 5.8e-15 54.9 21.5 1.8e-14 53.3 21.5 2.0 1 0 0 1 1 1 1 CXXC zinc finger domain HTH_12 PF08461.8 NM_001130823.2_3 - 0.1 12.4 0.1 0.26 11.1 0.1 1.6 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain Tetraspannin PF00335.18 NM_139022.2_3 - 3.4e-10 40.0 5.8 3.4e-10 40.0 5.8 1.7 2 0 0 2 2 2 1 Tetraspanin family LIM PF00412.20 NM_022363.2_2 - 1.2e-33 115.0 18.3 1.9e-17 63.1 1.8 2.2 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 NM_022363.2_2 - 1.5e-19 69.4 1.9 2.6e-19 68.7 1.9 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_022363.2_2 - 3.9e-05 23.3 0.1 8.7e-05 22.2 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain Furin-like_2 PF15913.3 NM_022363.2_2 - 0.2 11.7 12.3 0.13 12.3 10.4 1.6 1 1 0 1 1 1 0 Furin-like repeat, cysteine-rich I-set PF07679.14 NM_002465.3_3 - 1.8e-95 313.0 0.4 1.1e-18 66.9 0.0 7.4 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_002465.3_3 - 4.6e-64 212.9 0.1 2.2e-13 50.5 0.1 7.6 7 0 0 7 7 7 7 Immunoglobulin domain fn3 PF00041.19 NM_002465.3_3 - 3.9e-43 145.6 0.0 4.3e-14 52.5 0.0 4.3 5 0 0 5 5 5 3 Fibronectin type III domain Ig_2 PF13895.4 NM_002465.3_3 - 2.8e-34 117.2 0.1 2.5e-08 34.0 0.2 7.5 7 0 0 7 7 7 7 Immunoglobulin domain ig PF00047.23 NM_002465.3_3 - 6.5e-33 112.6 0.3 1.5e-08 34.5 0.0 7.4 7 0 0 7 7 7 6 Immunoglobulin domain V-set PF07686.15 NM_002465.3_3 - 1.3e-11 44.5 9.4 0.091 12.8 0.2 9.3 7 5 1 8 8 8 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_002465.3_3 - 3.8e-08 33.2 0.5 0.099 12.6 0.0 5.0 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 NM_002465.3_3 - 1.9e-06 28.1 0.3 11 6.4 0.0 6.5 6 0 0 6 6 6 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.13 NM_002465.3_3 - 4.2e-05 23.8 3.7 24 5.3 0.0 5.5 6 0 0 6 6 5 0 Immunoglobulin C1-set domain V-set_CD47 PF08204.9 NM_002465.3_3 - 0.0022 17.9 0.3 5.7 6.8 0.0 3.6 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain Pur_ac_phosph_N PF16656.3 NM_002465.3_3 - 0.033 14.6 1.2 0.6 10.6 0.1 3.5 4 1 0 4 4 3 0 Purple acid Phosphatase, N-terminal domain Ig_4 PF16680.3 NM_002465.3_3 - 0.21 11.8 7.9 8.9 6.6 0.0 5.9 6 1 0 6 6 6 0 T-cell surface glycoprotein CD3 delta chain AF-4 PF05110.11 NM_001169122.1_3 - 0 1247.6 55.9 1.7e-267 890.9 33.4 2.0 1 1 1 2 2 2 2 AF-4 proto-oncoprotein HAD_2 PF13419.4 NM_012080.4_3 - 2.2e-22 79.9 0.0 2.8e-22 79.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 NM_012080.4_3 - 4.1e-13 50.0 0.0 1.4e-12 48.2 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 NM_012080.4_3 - 0.00013 21.8 0.0 0.00022 21.1 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.4 NM_012080.4_3 - 0.027 14.5 0.0 0.72 9.9 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Integrin_alpha2 PF08441.10 NM_002203.3_3 - 1.1e-48 166.1 7.3 1.6e-48 165.6 7.3 1.1 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 NM_002203.3_3 - 1.6e-39 135.8 0.2 2.8e-39 135.1 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 NM_002203.3_3 - 4.4e-19 68.1 3.0 3.3e-08 33.4 0.3 3.5 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 NM_002203.3_3 - 1.9e-13 50.9 0.0 3.6e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 NM_002203.3_3 - 2.5e-05 24.6 7.0 0.001 19.5 1.6 3.2 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 NM_002203.3_3 - 3.7e-05 23.7 4.2 0.47 10.6 0.0 4.7 5 0 0 5 5 5 2 FG-GAP repeat Integrin_alpha PF00357.18 NM_002203.3_3 - 0.0032 17.2 2.2 0.0078 16.0 2.2 1.7 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region DHHA2 PF02833.12 NM_001303229.1_1 - 3e-29 101.9 0.0 4.4e-29 101.3 0.0 1.3 1 0 0 1 1 1 1 DHHA2 domain Calpain_inhib PF00748.17 NM_001303229.1_1 - 0.17 12.2 0.9 2.6 8.4 0.2 2.3 2 0 0 2 2 2 0 Calpain inhibitor zf-DHHC PF01529.18 NM_032327.3_1 - 5.7e-34 117.0 11.4 5.7e-34 117.0 11.4 2.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase Hormone_recep PF00104.28 NM_001134285.2_1 - 7e-32 110.6 0.6 1.3e-31 109.7 0.6 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_001134285.2_1 - 7.1e-30 103.1 12.3 7.1e-30 103.1 12.3 2.6 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Sulfate_transp PF00916.18 NM_134266.1_3 - 1.1e-92 310.6 25.1 1.5e-92 310.2 25.1 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 NM_134266.1_3 - 1.6e-18 66.3 0.0 3.2e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.4 NM_134266.1_3 - 0.0088 16.2 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 1 STAS domain PKI PF02827.14 NM_001322994.1_1 - 0.16 12.1 0.1 0.29 11.2 0.1 1.3 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor SH3-RhoG_link PF16609.3 NM_001322994.1_2 - 3.6e-41 141.5 13.9 7.5e-39 133.9 13.9 2.3 1 1 0 1 1 1 1 SH3-RhoGEF linking unstructured region RhoGEF PF00621.18 NM_001322994.1_2 - 3.3e-34 118.6 1.9 3.3e-34 118.6 1.9 1.9 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.27 NM_001322994.1_2 - 4.3e-05 23.8 0.0 9.6e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 NM_001322994.1_2 - 0.0046 17.1 0.3 0.017 15.3 0.2 2.1 2 1 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.3 NM_001322994.1_2 - 0.034 14.0 0.7 0.15 12.0 0.2 2.1 2 0 0 2 2 2 0 PH domain PH_13 PF16652.3 NM_001322994.1_2 - 0.071 12.9 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain WD40 PF00400.30 NM_001033522.1_3 - 1.4e-29 101.6 7.5 3.9e-06 27.4 0.0 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat CSTF1_dimer PF16699.3 NM_001033522.1_3 - 5.1e-24 83.7 0.3 8.8e-24 82.9 0.3 1.4 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain ANAPC4_WD40 PF12894.5 NM_001033522.1_3 - 7.4e-11 42.1 0.0 0.027 14.6 0.0 4.5 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.6 NM_001033522.1_3 - 2.1e-05 22.9 0.1 0.00028 19.2 0.0 2.0 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.3 NM_001033522.1_3 - 0.0087 14.9 0.6 1.2 7.9 0.1 2.6 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-H2C2_2 PF13465.4 NM_001253798.1_3 - 1e-86 281.7 104.5 2.2e-08 34.0 2.1 13.8 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001253798.1_3 - 1.5e-44 147.9 94.9 5.9e-05 23.2 1.1 13.5 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_001253798.1_3 - 3.1e-25 87.5 93.7 0.00096 18.9 0.5 13.1 13 0 0 13 13 12 11 C2H2-type zinc finger KRAB PF01352.25 NM_001253798.1_3 - 7.1e-25 86.3 0.9 7.1e-25 86.3 0.9 1.7 2 0 0 2 2 2 1 KRAB box zf-C2H2_4 PF13894.4 NM_001253798.1_3 - 3e-22 77.3 98.1 0.0035 17.9 0.8 14.0 13 0 0 13 13 12 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001253798.1_3 - 1.3e-14 53.9 61.2 0.002 18.1 1.0 7.7 6 2 0 6 6 6 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001253798.1_3 - 4.5e-07 29.9 61.8 0.34 11.1 1.0 12.5 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001253798.1_3 - 0.22 12.2 52.7 0.6 10.8 1.3 7.1 2 1 6 8 8 8 0 zinc-ribbon family zf-trcl PF13451.4 NM_001253798.1_3 - 0.26 11.1 58.4 4.6 7.1 0.1 11.7 10 2 0 10 10 10 0 Probable zinc-ribbon domain C1_4 PF07975.10 NM_001253798.1_3 - 0.57 10.4 52.1 0.85 9.8 1.5 8.2 2 2 7 9 9 9 0 TFIIH C1-like domain XPA_N PF01286.16 NM_001253798.1_3 - 3.3 7.7 58.9 8.1 6.4 0.0 12.2 12 0 0 12 12 12 0 XPA protein N-terminal PH_9 PF15410.4 NM_032289.2_2 - 1.8e-37 128.2 0.0 4.1e-37 127.1 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Sec7 PF01369.18 NM_032289.2_2 - 5.1e-35 120.7 0.0 7.8e-35 120.1 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 NM_032289.2_2 - 3e-12 46.9 0.1 5.5e-12 46.0 0.1 1.5 1 0 0 1 1 1 1 PH domain Pkinase PF00069.23 NM_182692.2_2 - 5.6e-40 137.2 7.6 1.3e-21 77.0 0.2 2.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_182692.2_2 - 5.7e-12 45.3 0.1 1.3e-08 34.3 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase HNOB PF07700.13 NM_182692.2_2 - 0.082 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Haem-NO-binding SCAN PF02023.15 NM_001146327.1_1 - 1.4e-30 104.8 1.1 4.8e-30 103.1 0.3 2.2 2 0 0 2 2 2 1 SCAN domain KRAB PF01352.25 NM_001146327.1_1 - 1.6e-23 81.9 1.5 1.1e-21 76.0 0.2 3.0 2 0 0 2 2 2 1 KRAB box zf-H2C2_2 PF13465.4 NM_001146327.1_1 - 1.9e-17 62.7 49.9 1.9e-08 34.2 0.8 7.2 6 1 1 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001146327.1_1 - 3.5e-15 55.4 51.5 0.00021 21.5 5.5 6.8 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001146327.1_1 - 2.1e-09 37.3 52.3 0.0013 19.3 0.9 6.5 6 1 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001146327.1_1 - 7.1e-05 22.3 32.0 0.0025 17.4 0.9 5.5 5 0 0 5 5 5 3 zinc-finger C2H2-type zf-met PF12874.5 NM_001146327.1_1 - 0.0044 17.2 34.6 0.0094 16.2 0.5 5.4 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001146327.1_1 - 0.03 14.5 0.5 0.03 14.5 0.5 5.2 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001146327.1_1 - 0.035 13.9 0.4 0.035 13.9 0.4 6.1 6 1 0 6 6 6 0 C2H2-type zinc finger NAD_binding_6 PF08030.10 NM_001184780.1_1 - 4.4e-31 108.0 0.0 7.2e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain EF-hand_1 PF00036.30 NM_001184780.1_1 - 5.2e-23 78.7 0.8 9.7e-06 24.7 0.0 4.4 4 0 0 4 4 4 4 EF hand FAD_binding_8 PF08022.10 NM_001184780.1_1 - 2.8e-21 75.5 0.0 5e-21 74.7 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.17 NM_001184780.1_1 - 1.6e-20 73.4 9.6 1.6e-20 73.4 9.6 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component EF-hand_6 PF13405.4 NM_001184780.1_1 - 2.8e-20 70.3 1.8 1.2e-05 24.7 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 NM_001184780.1_1 - 1.9e-18 65.0 5.1 7.9e-05 21.9 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 NM_001184780.1_1 - 6.4e-15 55.2 1.1 6.8e-09 35.9 0.3 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.4 NM_001184780.1_1 - 2.6e-08 33.4 0.3 0.003 17.1 0.0 3.6 2 1 1 3 3 3 3 EF-hand domain pair NAD_binding_1 PF00175.19 NM_001184780.1_1 - 0.00015 22.2 0.1 0.017 15.7 0.1 2.6 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.22 NM_001184780.1_1 - 0.013 15.7 0.0 0.027 14.7 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain EF-hand_9 PF14658.4 NM_001184780.1_1 - 0.14 12.4 0.0 0.93 9.7 0.0 2.5 2 1 1 3 3 2 0 EF-hand domain DUF4201 PF13870.4 NM_014157.3_2 - 2.7e-43 147.5 29.3 2.7e-43 147.5 29.3 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) HhH-GPD PF00730.23 NM_001276273.1_2 - 0.00045 20.5 0.0 0.00066 20.0 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein IL8 PF00048.18 NM_001565.3_1 - 5.2e-13 48.8 1.7 1.5e-12 47.4 1.7 1.8 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like C2 PF00168.28 NM_001174068.1_2 - 6.6e-41 138.6 0.0 3.1e-19 69.1 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 NM_001174068.1_2 - 5.7e-22 78.0 9.6 1.7e-21 76.5 9.6 1.8 1 0 0 1 1 1 1 FYVE-type zinc finger AreA_N PF07573.9 NM_001174068.1_2 - 0.015 15.8 0.3 0.034 14.7 0.3 1.5 1 0 0 1 1 1 0 Nitrogen regulatory protein AreA N terminus TSP_1 PF00090.17 NM_001323369.1_1 - 0.00034 20.6 6.1 0.0012 18.9 6.1 1.9 1 0 0 1 1 1 1 Thrombospondin type 1 domain IGFBP PF00219.16 NM_001323369.1_2 - 5.3e-11 42.9 19.3 5.3e-11 42.9 19.3 2.6 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Filament PF00038.19 NM_001131019.2_1 - 6.9e-110 367.4 51.6 8.2e-110 367.1 51.6 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 NM_001131019.2_1 - 4.2e-07 30.6 2.5 6.2e-07 30.1 1.0 2.1 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region DUF1664 PF07889.10 NM_001131019.2_1 - 0.018 14.9 13.7 0.13 12.2 1.7 3.2 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) Spc7 PF08317.9 NM_001131019.2_1 - 0.039 12.7 46.5 0.11 11.3 13.1 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 NM_001131019.2_1 - 0.14 11.4 6.3 0.7 9.1 1.2 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Golgin_A5 PF09787.7 NM_001131019.2_1 - 1.8 7.8 41.5 1.6 8.0 20.4 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 Jnk-SapK_ap_N PF09744.7 NM_001131019.2_1 - 1.8 8.6 48.3 1.3 9.1 18.1 3.4 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 WD40_alt PF14077.4 NM_001131019.2_1 - 3.5 7.4 6.0 1.5 8.6 2.0 2.5 2 1 0 2 2 2 0 Alternative WD40 repeat motif TPR_MLP1_2 PF07926.10 NM_001131019.2_1 - 5.3 7.0 51.5 5.8 6.8 17.5 3.8 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.6 NM_001131019.2_1 - 5.7 4.2 42.1 0.13 9.6 26.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Fib_alpha PF08702.8 NM_001131019.2_1 - 6 6.9 20.7 0.85 9.7 6.1 3.1 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.4 NM_001131019.2_1 - 6.7 5.8 34.8 1 8.5 14.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) GAS PF13851.4 NM_001131019.2_1 - 7.9 5.7 45.3 0.96 8.6 14.4 3.1 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.7 NM_001131019.2_1 - 8.8 6.2 43.7 1.9 8.4 10.9 3.6 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-H2C2_2 PF13465.4 NM_001317159.1_1 - 4.6e-12 45.7 52.9 7.4e-05 22.9 3.7 8.8 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001317159.1_1 - 1.6e-11 43.9 65.9 3e-05 24.1 0.5 7.5 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001317159.1_1 - 3.5e-11 42.8 64.2 0.0052 17.4 0.4 8.7 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001317159.1_1 - 0.0026 17.9 24.5 0.5 10.6 4.5 6.7 5 1 1 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001317159.1_1 - 0.16 12.3 26.6 0.022 15.0 4.6 5.3 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_001317159.1_1 - 0.96 9.1 29.8 1.5 8.6 2.0 6.2 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 NM_001317159.1_1 - 2.4 8.4 22.1 1.9 8.7 5.2 3.4 1 1 2 3 3 3 0 C2H2-type zinc ribbon NHL PF01436.19 NM_198514.3_2 - 1e-28 97.7 1.2 4.8e-06 26.2 0.0 6.7 7 0 0 7 7 7 4 NHL repeat Thioredoxin_8 PF13905.4 NM_198514.3_2 - 1e-10 41.6 0.0 2.1e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like SGL PF08450.10 NM_198514.3_2 - 8.9e-06 25.3 0.1 0.0097 15.4 0.0 3.0 2 1 1 3 3 3 3 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.18 NM_198514.3_2 - 0.00034 20.6 0.0 1.5 9.0 0.0 3.5 3 0 0 3 3 3 2 Arylesterase Thioredoxin PF00085.18 NM_198514.3_2 - 0.093 12.5 0.0 1.2 9.0 0.1 2.2 1 1 1 2 2 2 0 Thioredoxin C2 PF00168.28 NM_014989.5_1 - 8.7e-38 128.6 0.0 2.9e-18 65.9 0.1 2.6 2 0 0 2 2 2 2 C2 domain PDZ PF00595.22 NM_014989.5_1 - 1.2e-09 38.3 0.0 2.3e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FYVE_2 PF02318.14 NM_014989.5_1 - 4.4e-07 30.0 18.2 1.8e-06 28.0 8.4 2.7 1 1 1 2 2 2 2 FYVE-type zinc finger Ig_2 PF13895.4 NM_005874.4_3 - 1.1e-29 102.4 1.4 2.2e-13 50.2 0.1 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 NM_005874.4_3 - 2.7e-24 85.4 1.5 3.6e-05 24.2 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 NM_005874.4_3 - 7.7e-16 57.9 0.0 0.00057 19.9 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain SIT PF15330.4 NM_005874.4_3 - 0.0073 16.6 0.0 0.019 15.3 0.0 1.7 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT EphA2_TM PF14575.4 NM_005874.4_3 - 0.3 11.8 2.7 0.38 11.5 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain HemY_N PF07219.11 NM_005874.4_3 - 0.34 11.0 1.7 0.69 10.0 1.7 1.4 1 0 0 1 1 1 0 HemY protein N-terminus DUF912 PF06024.10 NM_005874.4_3 - 0.62 10.3 0.0 0.62 10.3 0.0 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Latrophilin PF02354.14 NM_001322246.1_1 - 1.4e-84 284.2 5.6 1.8e-84 283.8 5.6 1.1 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region OLF PF02191.14 NM_001322246.1_3 - 2.5e-83 279.3 6.5 2.5e-83 279.3 5.1 1.7 2 0 0 2 2 2 1 Olfactomedin-like domain 7tm_2 PF00002.22 NM_001322246.1_3 - 3e-69 232.9 19.3 4.7e-69 232.3 19.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.3 NM_001322246.1_3 - 7e-54 182.3 2.8 1.1e-53 181.7 2.8 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Latrophilin PF02354.14 NM_001322246.1_3 - 2.4e-31 109.0 7.7 3.7e-31 108.4 7.7 1.1 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region Gal_Lectin PF02140.16 NM_001322246.1_3 - 2e-23 82.5 0.7 5.2e-23 81.1 0.7 1.8 1 0 0 1 1 1 1 Galactose binding lectin domain GPS PF01825.19 NM_001322246.1_3 - 1.5e-14 54.2 6.7 3.6e-14 53.0 6.7 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 NM_001322246.1_3 - 1.5e-05 25.0 0.5 3.7e-05 23.8 0.5 1.7 1 0 0 1 1 1 1 Hormone receptor domain Methyltransf_23 PF13489.4 NM_001301790.1_1 - 8.8e-08 32.1 0.1 1.4e-07 31.4 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_001301790.1_1 - 5.9e-07 30.0 0.6 3.2e-06 27.6 0.6 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_001301790.1_1 - 9.5e-05 22.9 0.0 0.00019 22.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001301790.1_1 - 0.00033 21.1 0.1 0.00056 20.4 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Glyco_hydro_18 PF00704.26 NM_001142674.1_2 - 1.4e-18 67.5 0.0 1.8e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DJ-1_PfpI PF01965.22 NM_001318821.1_2 - 0.12 12.0 0.0 0.31 10.7 0.0 1.6 2 0 0 2 2 2 0 DJ-1/PfpI family zf-RING_2 PF13639.4 NM_004719.2_3 - 9.3e-07 28.9 8.2 3.5e-06 27.0 8.2 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_004719.2_3 - 2.1e-05 24.1 8.2 7e-05 22.5 8.2 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_004719.2_3 - 6.8e-05 23.0 4.7 0.00038 20.6 4.7 2.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 NM_004719.2_3 - 0.00034 20.3 8.9 0.0017 18.1 8.9 2.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_004719.2_3 - 0.0004 20.0 5.0 0.0004 20.0 5.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_004719.2_3 - 0.00092 19.0 8.6 0.0042 16.9 8.6 2.3 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 NM_004719.2_3 - 0.0018 18.1 6.0 0.0072 16.1 6.0 2.2 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 NM_004719.2_3 - 0.0048 16.6 5.5 0.021 14.5 5.7 2.2 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 NM_004719.2_3 - 0.041 13.8 1.5 0.12 12.3 1.5 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 NM_004719.2_3 - 0.063 13.3 9.4 0.19 11.8 9.4 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.3 NM_004719.2_3 - 1.1 8.8 5.1 3.4 7.2 5.1 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.3 NM_004719.2_3 - 4.8 6.9 9.1 12 5.6 9.1 1.7 1 0 0 1 1 1 0 RING-like zinc finger CITED PF04487.10 NM_001144887.1_3 - 4.3e-31 108.5 0.1 1.1e-30 107.1 0.0 1.4 1 1 0 2 2 2 1 CITED zf-H2C2_2 PF13465.4 NM_001278677.1_2 - 2.1e-96 312.2 135.0 5.3e-09 36.0 1.6 18.6 18 0 0 18 18 18 16 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001278677.1_2 - 1.4e-65 214.1 94.9 3e-05 24.1 0.5 16.7 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001278677.1_2 - 4.4e-28 95.4 95.2 0.014 16.1 0.7 15.8 15 0 0 15 15 14 13 C2H2-type zinc finger KRAB PF01352.25 NM_001278677.1_2 - 6.5e-22 76.8 0.2 1.1e-21 76.1 0.2 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001278677.1_2 - 2.5e-20 72.1 53.3 0.067 13.4 0.2 15.0 15 0 0 15 15 14 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001278677.1_2 - 1.8e-17 62.7 79.4 0.022 14.6 0.3 16.2 15 0 0 15 15 15 8 C2H2-type zinc finger XPA_N PF01286.16 NM_001278677.1_2 - 2.7e-16 59.2 71.5 0.61 10.0 0.1 15.7 16 0 0 16 16 16 13 XPA protein N-terminal Zn-ribbon_8 PF09723.8 NM_001278677.1_2 - 8.7e-13 48.0 82.0 0.089 12.8 4.5 11.2 4 2 10 14 14 14 13 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001278677.1_2 - 1.9e-11 43.4 42.3 2.9 7.6 0.0 14.9 15 0 0 15 15 15 6 zinc-finger C2H2-type zf-trcl PF13451.4 NM_001278677.1_2 - 1.1e-10 41.1 67.0 0.39 10.5 0.1 12.9 11 3 1 12 12 12 7 Probable zinc-ribbon domain SprT-like PF10263.7 NM_001278677.1_2 - 1.2e-06 28.3 78.2 0.056 13.1 5.5 7.8 1 1 5 7 7 7 6 SprT-like family ADK_lid PF05191.12 NM_001278677.1_2 - 0.0085 16.0 46.8 1.7 8.6 0.6 8.7 3 2 5 8 8 8 4 Adenylate kinase, active site lid DZR PF12773.5 NM_001278677.1_2 - 0.014 15.3 59.5 1.6e+04 -41.0 59.5 7.9 1 1 0 1 1 0 0 Double zinc ribbon ROS_MUCR PF05443.9 NM_001278677.1_2 - 0.022 14.7 0.1 8.9 6.3 0.0 3.1 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein BolA PF01722.16 NM_001278677.1_2 - 9.1 6.5 15.0 49 4.2 0.1 6.3 4 2 2 6 6 6 0 BolA-like protein Antimicrobial_2 PF08023.10 NM_001278677.1_3 - 0.0039 17.6 0.2 54 4.3 0.0 5.9 7 1 0 7 7 7 2 Frog antimicrobial peptide zf-H2C2_2 PF13465.4 NM_001018011.1_2 - 8.5e-36 120.7 53.0 1.2e-07 31.8 1.4 9.8 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001018011.1_2 - 1.8e-28 96.6 59.6 0.00016 22.1 1.8 9.6 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001018011.1_2 - 2.1e-27 93.9 61.3 0.00024 21.2 2.6 9.4 9 0 0 9 9 9 8 Zinc finger, C2H2 type BTB PF00651.29 NM_001018011.1_2 - 4.8e-26 91.0 3.2 9.1e-26 90.1 3.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_6 PF13912.4 NM_001018011.1_2 - 3.6e-14 52.2 50.0 2.4e-06 27.2 0.2 9.5 10 0 0 10 10 10 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001018011.1_2 - 1.4e-13 50.6 38.6 0.00017 21.7 0.4 9.7 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001018011.1_2 - 1.5e-12 47.4 52.3 5.1e-05 23.4 1.1 9.6 9 0 0 9 9 9 5 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.5 NM_001018011.1_2 - 0.0039 17.4 43.9 0.34 11.1 0.4 8.3 1 1 8 9 9 9 3 C2H2 type zinc-finger (2 copies) DZR PF12773.5 NM_001018011.1_2 - 0.021 14.7 30.3 17 5.4 6.3 5.3 2 1 2 4 4 4 0 Double zinc ribbon Endonuclease_7 PF02945.13 NM_001018011.1_2 - 0.024 14.4 1.4 0.024 14.4 1.4 4.0 2 2 2 4 4 4 0 Recombination endonuclease VII zinc_ribbon_15 PF17032.3 NM_001018011.1_2 - 0.056 14.1 26.8 0.97 10.1 1.8 5.3 1 1 5 6 6 6 0 zinc-ribbon family DUF3268 PF11672.6 NM_001018011.1_2 - 1.4 9.1 21.3 6.4 7.0 0.2 4.9 4 1 1 5 5 5 0 zinc-finger-containing domain zf-C2H2_11 PF16622.3 NM_001018011.1_2 - 2.3 7.9 50.6 0.029 14.0 1.4 8.4 9 0 0 9 9 9 0 zinc-finger C2H2-type SNF2_N PF00176.21 NM_032221.4_2 - 1.5e-63 214.5 1.8 2.3e-63 213.9 1.8 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.22 NM_032221.4_2 - 5.3e-24 83.7 4.6 1.2e-13 50.6 1.8 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.29 NM_032221.4_2 - 1.3e-16 60.8 0.0 3e-16 59.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_032221.4_2 - 7.9e-08 32.4 0.1 3.5e-07 30.2 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.9 NM_032221.4_2 - 2.3e-05 24.5 0.0 0.41 10.7 0.0 3.5 3 0 0 3 3 3 2 CHDCT2 (NUC038) domain DEAD PF00270.27 NM_032221.4_2 - 0.00029 20.5 0.0 0.00054 19.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.6 NM_032221.4_2 - 0.0019 17.3 0.0 0.0067 15.5 0.0 1.8 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DUF3437 PF11919.6 NM_032221.4_2 - 0.11 12.4 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) V-set PF07686.15 NM_001159708.1_1 - 1.5e-08 34.6 0.1 4.5e-08 33.1 0.0 1.9 3 0 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.14 NM_001159708.1_1 - 2.7e-06 27.2 0.0 0.077 12.9 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001159708.1_1 - 0.00029 21.2 0.0 0.53 10.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001159708.1_1 - 0.015 15.3 0.0 9.3 6.4 0.0 2.8 2 1 0 2 2 2 0 Immunoglobulin domain C2-set_2 PF08205.10 NM_001159708.1_1 - 0.083 12.8 0.1 0.42 10.6 0.0 2.0 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain SPRY PF00622.26 NM_001159708.1_2 - 6.2e-15 55.2 0.0 1.3e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_001159708.1_2 - 4.4e-14 51.7 0.3 1e-13 50.5 0.3 1.7 1 0 0 1 1 1 1 SPRY-associated domain Trypsin PF00089.24 NM_000131.4_1 - 1.4e-58 198.2 0.1 2.1e-58 197.6 0.1 1.3 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 NM_000131.4_1 - 2.1e-18 66.1 4.8 2.1e-18 66.1 4.8 1.7 2 0 0 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain DUF1986 PF09342.9 NM_000131.4_1 - 2.7e-08 34.0 0.0 4.9e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) FXa_inhibition PF14670.4 NM_000131.4_1 - 1.6e-07 31.3 11.4 1.6e-07 31.3 11.4 3.8 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site EGF PF00008.25 NM_000131.4_1 - 0.00013 22.0 4.9 0.00013 22.0 4.9 3.4 3 0 0 3 3 3 1 EGF-like domain cEGF PF12662.5 NM_000131.4_1 - 0.00026 20.7 1.2 0.00026 20.7 1.2 4.5 5 0 0 5 5 5 1 Complement Clr-like EGF-like hEGF PF12661.5 NM_000131.4_1 - 0.0022 18.5 2.1 0.0022 18.5 2.1 3.9 3 1 0 3 3 3 1 Human growth factor-like EGF RNase_Zc3h12a PF11977.6 NM_015299.2_2 - 1.3e-61 206.8 0.0 1.8e-61 206.4 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain Arm_2 PF04826.11 NM_001184875.2_1 - 5.3e-55 186.5 4.2 7.5e-55 186.0 4.2 1.1 1 0 0 1 1 1 1 Armadillo-like zf-C2H2 PF00096.24 NM_199262.2_3 - 1.7e-14 53.2 18.7 5.7e-05 23.2 0.7 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_199262.2_3 - 2.5e-08 33.9 18.1 0.0021 18.6 1.3 4.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_199262.2_3 - 6.9e-08 32.5 5.7 4.4e-05 23.6 0.6 4.8 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_6 PF13912.4 NM_199262.2_3 - 0.00018 21.2 5.0 0.00085 19.1 0.5 3.0 2 0 0 2 2 2 1 C2H2-type zinc finger UL11 PF11094.6 NM_199262.2_3 - 0.13 12.0 2.0 0.32 10.8 2.0 1.7 1 0 0 1 1 1 0 Membrane-associated tegument protein zf-C2H2_aberr PF17017.3 NM_199262.2_3 - 6.3 6.8 6.2 3.7 7.5 0.2 2.7 3 0 0 3 3 3 0 Aberrant zinc-finger LRR_4 PF12799.5 NM_012160.4_2 - 3.1e-10 40.0 12.6 0.0055 16.9 0.0 7.5 2 1 7 9 9 9 7 Leucine Rich repeats (2 copies) F-box PF00646.31 NM_012160.4_2 - 4.3e-07 29.5 0.3 4.3e-07 29.5 0.3 2.8 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.5 NM_012160.4_2 - 2.9e-05 23.7 2.4 2.9e-05 23.7 2.4 2.2 2 0 0 2 2 2 1 F-box-like LRR_9 PF14580.4 NM_012160.4_2 - 0.00069 19.0 1.1 0.57 9.5 0.1 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.4 NM_012160.4_2 - 0.00076 19.1 4.7 0.28 10.9 0.1 4.3 2 2 2 4 4 4 2 Leucine rich repeat LRR_6 PF13516.4 NM_012160.4_2 - 0.0011 18.7 4.5 18 5.5 0.2 5.8 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.31 NM_012160.4_2 - 0.0023 18.0 10.6 16 6.3 0.2 7.0 6 1 0 6 6 6 1 Leucine Rich Repeat F-box_4 PF15966.3 NM_012160.4_2 - 0.0029 17.3 0.3 0.011 15.5 0.3 2.0 1 1 0 1 1 1 1 F-box Adeno_E3_CR2 PF02439.13 NM_012160.4_2 - 0.016 14.8 1.3 0.032 13.8 1.3 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 7tm_1 PF00001.19 NM_001166215.1_2 - 2.1e-32 112.3 0.4 3.6e-32 111.5 0.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_001166215.1_2 - 0.0035 17.0 0.5 0.28 10.8 0.3 2.3 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 NM_001166215.1_2 - 0.032 13.5 0.0 0.2 10.9 0.0 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx ANF_receptor PF01094.26 NM_000828.4_3 - 1.7e-59 201.6 0.7 2.3e-59 201.2 0.7 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 NM_000828.4_3 - 1.3e-58 197.0 0.0 2.5e-58 196.0 0.0 1.5 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_000828.4_3 - 6.5e-45 151.9 0.0 1.3e-44 150.9 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_000828.4_3 - 1e-21 77.3 0.0 1.8e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 zf-H2C2_2 PF13465.4 NM_001318535.1_2 - 6.8e-96 310.7 101.5 2.3e-09 37.2 0.3 14.8 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001318535.1_2 - 9.4e-57 186.3 118.1 2.6e-06 27.4 0.1 14.7 14 0 0 14 14 14 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001318535.1_2 - 1.1e-30 103.4 117.5 0.00072 20.0 3.2 15.1 15 0 0 15 15 14 12 C2H2-type zinc finger KRAB PF01352.25 NM_001318535.1_2 - 8e-24 82.9 0.3 1.5e-23 82.0 0.3 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001318535.1_2 - 2.1e-22 78.4 96.9 5.5e-05 22.9 0.2 14.8 15 0 0 15 15 14 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001318535.1_2 - 9.8e-10 38.3 77.9 0.0071 16.3 1.9 10.1 6 3 5 11 11 11 8 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001318535.1_2 - 1.7e-09 37.6 55.5 0.046 13.9 0.0 12.4 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_001318535.1_2 - 1.3e-08 34.3 71.4 0.051 13.2 0.1 13.8 14 0 0 14 14 14 5 zinc-finger C2H2-type XPA_N PF01286.16 NM_001318535.1_2 - 7e-05 22.6 61.7 1.8 8.6 0.4 13.7 14 0 0 14 14 14 4 XPA protein N-terminal DZR PF12773.5 NM_001318535.1_2 - 9.8e-05 22.2 69.9 0.29 11.0 4.2 8.2 1 1 4 5 5 4 2 Double zinc ribbon zinc_ribbon_15 PF17032.3 NM_001318535.1_2 - 0.00083 19.9 68.0 0.4 11.3 1.0 8.1 1 1 5 8 8 8 3 zinc-ribbon family DUF3268 PF11672.6 NM_001318535.1_2 - 0.065 13.4 49.3 0.71 10.1 2.0 7.5 4 2 3 8 8 8 0 zinc-finger-containing domain FYVE PF01363.19 NM_001318535.1_2 - 1.5 8.9 78.9 1 9.4 1.7 8.6 1 1 4 6 6 6 0 FYVE zinc finger BolA PF01722.16 NM_001318535.1_2 - 3.1 8.0 17.2 13 6.0 0.2 6.0 3 2 3 6 6 6 0 BolA-like protein zf-trcl PF13451.4 NM_001318535.1_2 - 5 6.9 60.5 6.9 6.5 0.2 13.6 13 1 0 13 13 13 0 Probable zinc-ribbon domain PH PF00169.27 NM_015230.3_3 - 7.6e-45 151.6 16.3 1.4e-11 44.7 0.4 5.8 5 0 0 5 5 5 5 PH domain RhoGAP PF00620.25 NM_015230.3_3 - 3.4e-41 140.4 0.1 1.2e-39 135.5 0.0 2.5 2 0 0 2 2 2 1 RhoGAP domain ArfGap PF01412.16 NM_015230.3_3 - 4e-34 117.0 1.6 1.3e-33 115.4 1.1 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf SAM_1 PF00536.28 NM_015230.3_3 - 3.2e-10 40.1 0.1 1e-09 38.5 0.1 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_015230.3_3 - 1.3e-09 37.9 0.1 3.4e-09 36.5 0.1 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_6 PF15406.4 NM_015230.3_3 - 1.9e-09 37.6 0.1 5.9e-05 23.2 0.0 3.7 3 0 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.4 NM_015230.3_3 - 2.4e-08 33.9 1.9 0.003 17.5 0.1 3.9 3 0 0 3 3 3 2 PH domain PH_11 PF15413.4 NM_015230.3_3 - 6e-07 29.7 19.2 0.12 12.7 1.3 6.9 6 2 0 6 6 6 3 Pleckstrin homology domain RA PF00788.21 NM_015230.3_3 - 3e-05 24.4 0.0 0.00012 22.5 0.0 2.1 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH_8 PF15409.4 NM_015230.3_3 - 4.7e-05 23.4 9.2 0.64 10.2 0.1 5.9 5 1 0 5 5 5 1 Pleckstrin homology domain PH_9 PF15410.4 NM_015230.3_3 - 0.0067 16.7 2.7 33 4.7 0.0 4.7 4 0 0 4 4 4 0 Pleckstrin homology domain Mcp5_PH PF12814.5 NM_015230.3_3 - 0.062 13.3 0.6 1.3 9.0 0.0 2.9 3 0 0 3 3 3 0 Meiotic cell cortex C-terminal pleckstrin homology PH_2 PF08458.8 NM_015230.3_3 - 0.2 11.9 4.9 3.4 7.9 0.1 3.4 4 0 0 4 4 4 0 Plant pleckstrin homology-like region VWD PF00094.23 NM_015230.3_3 - 3.7 7.7 5.5 4.3 7.5 0.5 2.8 3 0 0 3 3 3 0 von Willebrand factor type D domain ADAM_spacer1 PF05986.12 NM_001288607.1_2 - 7.7e-26 90.2 0.0 1.2e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.17 NM_001288607.1_2 - 8e-26 89.9 99.0 5e-06 26.5 10.0 9.2 8 0 0 8 8 8 8 Thrombospondin type 1 domain PLAC PF08686.9 NM_001288607.1_2 - 1.3e-10 41.6 7.8 7e-10 39.3 7.8 2.4 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain C2 PF00168.28 NM_015531.5_3 - 3.1e-18 65.8 0.1 3e-05 24.1 0.0 6.1 6 0 0 6 6 6 4 C2 domain NT-C2 PF10358.7 NM_015531.5_3 - 0.0051 16.4 0.3 0.85 9.2 0.0 3.9 4 0 0 4 4 4 1 N-terminal C2 in EEIG1 and EHBP1 proteins UPF0560 PF10577.7 NM_001010924.1_2 - 0 1266.5 1.3 0 1266.3 1.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0560 FAM176 PF14851.4 NM_001010924.1_2 - 0.31 10.6 3.0 38 3.8 3.5 2.5 2 0 0 2 2 2 0 FAM176 family DEAD PF00270.27 NM_004398.3_1 - 4.8e-49 166.4 3.7 5.1e-49 166.3 0.1 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_004398.3_1 - 1.8e-24 86.1 0.2 1.3e-23 83.3 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.4 NM_004398.3_1 - 6.2e-19 67.8 0.1 1.8e-18 66.4 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.13 NM_004398.3_1 - 2.1e-10 40.8 4.4 2.3e-10 40.6 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2390 PF09523.8 NM_004398.3_1 - 0.086 13.0 0.0 0.086 13.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2390) PWWP PF00855.15 NM_004494.2_2 - 1.3e-14 54.3 0.1 2.2e-14 53.5 0.1 1.4 1 0 0 1 1 1 1 PWWP domain WWE PF02825.18 NM_001242851.1_2 - 4.2e-16 59.1 2.5 9.3e-16 58.0 2.5 1.6 1 0 0 1 1 1 1 WWE domain zf-C3HC4_3 PF13920.4 NM_001242851.1_2 - 1.9e-06 27.5 10.7 1.9e-06 27.5 10.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001242851.1_2 - 0.00028 20.9 12.6 0.00028 20.9 12.6 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.23 NM_001242851.1_2 - 0.00043 20.0 11.6 0.00043 20.0 11.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001242851.1_2 - 0.00047 20.0 9.3 0.00047 20.0 9.3 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_001242851.1_2 - 0.0018 17.9 12.0 0.0018 17.9 12.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_001242851.1_2 - 0.007 16.1 10.2 0.018 14.7 10.2 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.3 NM_001242851.1_2 - 1.6 8.4 10.8 7.5 6.2 10.8 2.3 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.4 NM_001242851.1_2 - 1.9 8.4 17.7 0.066 13.1 11.4 1.9 2 0 0 2 2 2 0 zinc-RING finger domain IBR PF01485.19 NM_001323958.1_1 - 4.5e-07 29.9 19.6 6.6e-05 22.9 8.1 4.4 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain zf-RanBP PF00641.16 NM_001323958.1_3 - 2.1e-05 23.6 2.5 7e-05 21.9 2.5 1.9 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others ubiquitin PF00240.21 NM_001323958.1_3 - 0.012 15.2 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family PAF-AH_p_II PF03403.11 NM_005084.3_3 - 1.5e-182 606.1 0.0 1.9e-182 605.8 0.0 1.1 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.5 NM_005084.3_3 - 1.1e-08 34.1 0.0 4.8e-08 32.1 0.0 1.9 1 1 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.6 NM_005084.3_3 - 1.2e-06 27.8 0.0 0.012 14.7 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 NM_005084.3_3 - 2.8e-06 27.0 0.0 7.1e-06 25.7 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_005084.3_3 - 7e-05 22.3 0.0 0.00015 21.1 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase PF07224.9 NM_005084.3_3 - 7.1e-05 21.8 0.1 0.0041 16.1 0.0 2.1 1 1 0 2 2 2 1 Chlorophyllase Abhydrolase_6 PF12697.5 NM_005084.3_3 - 0.00028 21.4 0.0 0.0013 19.2 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.5 NM_005084.3_3 - 0.0018 17.9 0.0 0.0037 16.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 NM_005084.3_3 - 0.0081 15.9 0.0 0.17 11.5 0.0 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase DLH PF01738.16 NM_005084.3_3 - 0.033 13.6 0.0 0.066 12.6 0.0 1.5 1 1 0 1 1 1 0 Dienelactone hydrolase family PGAP1 PF07819.11 NM_005084.3_3 - 0.15 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Pkinase PF00069.23 NM_199462.2_2 - 1.7e-26 93.0 0.0 6.1e-26 91.2 0.0 1.8 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_199462.2_2 - 3.3e-23 82.1 0.0 1e-20 74.0 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Kdo PF06293.12 NM_199462.2_2 - 0.0076 15.5 0.1 0.015 14.5 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_199462.2_2 - 0.0091 15.2 0.1 0.018 14.3 0.1 1.4 1 0 0 1 1 1 1 Kinase-like Chlam_OMP PF01308.15 NM_001286802.1_1 - 0.16 10.6 0.2 0.25 9.9 0.2 1.2 1 0 0 1 1 1 0 Chlamydia major outer membrane protein Methyltransf_PK PF05891.10 NM_001286802.1_2 - 2e-71 239.9 0.0 2.4e-71 239.6 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.4 NM_001286802.1_2 - 2.5e-12 47.2 0.0 5.8e-12 46.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001286802.1_2 - 8.4e-11 42.2 0.0 1.2e-10 41.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_001286802.1_2 - 4.7e-09 36.7 0.0 6.9e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.16 NM_001286802.1_2 - 0.00024 20.3 0.0 0.00033 19.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_31 PF13847.4 NM_001286802.1_2 - 0.00025 20.7 0.0 0.00036 20.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 NM_001286802.1_2 - 0.00054 19.2 0.0 0.00071 18.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.4 NM_001286802.1_2 - 0.0025 17.6 0.0 0.0041 16.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RAD51_interact PF15696.3 NM_006479.4_1 - 6.9e-19 67.5 7.6 6.9e-19 67.5 7.6 2.3 3 0 0 3 3 3 1 RAD51 interacting motif 7tm_1 PF00001.19 NM_004835.4_3 - 2.2e-50 171.2 22.7 3.3e-50 170.7 22.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_004835.4_3 - 3.5e-07 29.7 22.4 5.8e-07 29.0 22.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Laminin_G_2 PF02210.22 NM_138732.2_1 - 7.8e-159 520.8 6.7 2.1e-29 102.6 0.2 6.4 6 0 0 6 6 6 6 Laminin G domain Laminin_G_1 PF00054.21 NM_138732.2_1 - 5.8e-105 346.7 0.0 6.4e-21 74.8 0.0 6.5 6 0 0 6 6 6 6 Laminin G domain Laminin_G_3 PF13385.4 NM_138732.2_1 - 1.8e-30 106.0 1.0 0.00046 20.2 0.0 6.3 6 0 0 6 6 6 6 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 NM_138732.2_1 - 1.5e-06 28.2 32.0 0.0022 18.1 4.1 4.0 3 0 0 3 3 3 3 EGF-like domain Syndecan PF01034.18 NM_138732.2_1 - 1.5e-06 27.9 0.0 2.9e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain DUF202 PF02656.13 NM_138732.2_1 - 0.088 13.1 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) GST_C_2 PF13410.4 NM_053277.2_2 - 8.9e-07 28.6 0.0 2.1e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 NM_053277.2_2 - 0.00038 20.6 0.0 0.00071 19.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 NM_053277.2_2 - 0.00044 20.4 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 NM_053277.2_2 - 0.033 14.3 0.0 0.073 13.2 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain EGF_CA PF07645.13 NM_001004019.1_3 - 3.4e-85 279.9 166.8 4.8e-11 42.6 11.1 13.8 13 0 0 13 13 13 10 Calcium-binding EGF domain cEGF PF12662.5 NM_001004019.1_3 - 1.1e-62 207.3 99.9 1.3e-09 37.7 3.6 14.3 14 0 0 14 14 14 10 Complement Clr-like EGF-like FXa_inhibition PF14670.4 NM_001004019.1_3 - 2.4e-22 78.8 66.3 5.3e-10 39.3 6.0 14.7 13 2 2 15 15 15 7 Coagulation Factor Xa inhibitory site ANATO PF01821.16 NM_001004019.1_3 - 3.8e-06 27.5 19.3 2.7e-05 24.8 6.6 9.9 9 2 1 11 11 11 2 Anaphylotoxin-like domain EGF PF00008.25 NM_001004019.1_3 - 1.8e-05 24.8 10.2 0.00046 20.3 3.6 15.5 15 1 1 16 16 16 6 EGF-like domain EGF_3 PF12947.5 NM_001004019.1_3 - 0.00055 19.9 150.3 0.0099 15.9 7.0 13.7 13 1 1 14 14 14 9 EGF domain hEGF PF12661.5 NM_001004019.1_3 - 0.0082 16.7 0.8 0.0082 16.7 0.8 15.6 14 2 0 14 14 14 5 Human growth factor-like EGF FAM27 PF15832.3 NM_021783.4_1 - 0.33 11.4 5.5 0.66 10.4 5.5 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family TNFR_c6 PF00020.16 NM_021783.4_3 - 8.3e-12 45.2 29.7 5e-07 29.9 7.6 4.1 3 0 0 3 3 3 2 TNFR/NGFR cysteine-rich region Abhydrolase_1 PF00561.18 NM_177525.2_1 - 1.1e-16 61.1 0.1 1e-14 54.7 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_177525.2_1 - 4.3e-10 40.4 0.1 6.2e-10 39.9 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1057 PF06342.10 NM_177525.2_1 - 3e-05 23.1 0.0 4.3e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Hydrolase_4 PF12146.6 NM_177525.2_1 - 0.00034 19.8 0.0 0.0043 16.2 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 SAM_2 PF07647.15 NM_080621.4_2 - 1.9e-18 66.2 0.3 2.9e-18 65.6 0.3 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_080621.4_2 - 1.3e-07 31.9 0.1 2.1e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_080621.4_2 - 4.7e-05 23.1 0.0 9.7e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Lipocalin_7 PF14651.4 NM_001040442.1_1 - 1.1e-80 267.7 3.8 1.5e-80 267.3 3.8 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Glyco_hydro_4C PF11975.6 NM_001040442.1_1 - 0.078 12.9 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain Spt20 PF12090.6 NM_001278482.1_3 - 7.2e-34 117.3 0.6 9e-20 71.1 0.0 4.3 4 1 1 5 5 5 3 Spt20 family Ras PF00071.20 NM_001271998.1_3 - 1.6e-14 53.7 0.1 2.5e-14 53.1 0.1 1.2 1 0 0 1 1 1 1 Ras family Cadherin PF00028.15 NM_021153.3_1 - 1.1e-64 214.8 12.9 1.8e-16 60.2 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 NM_021153.3_1 - 1.7e-48 164.1 1.6 1e-46 158.4 0.2 2.4 2 0 0 2 2 2 2 Cadherin cytoplasmic region Cadherin_2 PF08266.10 NM_021153.3_1 - 2.1e-07 30.5 0.0 0.082 12.6 0.0 4.1 3 1 0 3 3 3 3 Cadherin-like DUF4628 PF15429.4 NM_001085375.1_2 - 1e-117 392.6 3.2 1.3e-117 392.3 3.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4628) HSP70 PF00012.18 NM_005347.4_1 - 4.4e-271 900.2 9.3 5.2e-271 900.0 9.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 NM_005347.4_1 - 3.4e-17 62.1 0.5 3.4e-16 58.9 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 NM_005347.4_1 - 0.00042 20.6 4.4 0.58 10.5 0.1 4.0 4 1 0 4 4 4 2 Cell division protein FtsA DUF4624 PF15417.4 NM_005347.4_1 - 0.0041 16.8 0.1 0.54 9.9 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4624) Hydantoinase_A PF01968.16 NM_005347.4_1 - 0.016 14.3 1.7 0.032 13.3 0.1 2.2 2 1 0 2 2 2 0 Hydantoinase/oxoprolinase DDR PF08841.8 NM_005347.4_1 - 0.019 13.8 0.4 0.056 12.3 0.4 1.5 1 1 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.14 NM_005347.4_1 - 0.097 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain DUF4795 PF16043.3 NM_005347.4_1 - 3.1 7.2 10.9 0.38 10.2 4.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) DARPP-32 PF05395.10 NM_001261425.1_3 - 7.1e-28 97.7 6.5 1e-27 97.2 6.5 1.2 1 0 0 1 1 1 1 Protein phosphatase inhibitor 1/DARPP-32 Homeobox PF00046.27 NM_147192.2_1 - 9.4e-22 76.5 3.6 1.9e-21 75.5 3.6 1.5 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 NM_147192.2_1 - 2.6e-05 23.8 1.2 5.6e-05 22.7 1.2 1.6 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 NM_147192.2_1 - 0.088 12.6 0.1 0.088 12.6 0.1 1.9 2 0 0 2 2 2 0 Homeobox KN domain APA3_viroporin PF11289.6 NM_147192.2_1 - 0.2 11.0 0.0 0.31 10.4 0.0 1.1 1 0 0 1 1 1 0 Coronavirus accessory protein 3a Selenoprotein_S PF06936.9 NM_147192.2_1 - 1 9.0 5.2 2.6 7.7 5.2 1.6 2 0 0 2 2 2 0 Selenoprotein S (SelS) V-set PF07686.15 NM_001098506.3_1 - 7.6e-25 87.1 1.0 8.7e-16 57.9 0.0 3.2 2 1 1 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001098506.3_1 - 6.9e-18 64.9 1.2 8.6e-12 45.4 0.6 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_001098506.3_1 - 1.8e-16 60.1 4.6 3.4e-12 46.4 0.9 3.1 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_001098506.3_1 - 1.6e-15 56.8 0.2 3.2e-11 43.0 0.1 2.5 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 NM_001098506.3_1 - 1.9e-15 56.7 2.3 4e-12 46.0 1.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.3 NM_001098506.3_1 - 0.0069 16.3 0.1 0.11 12.4 0.0 2.4 2 1 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 NM_001098506.3_1 - 0.0092 16.2 0.2 0.074 13.3 0.1 2.2 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Tankyrase_bdg_C PF15327.4 NM_001145206.1_3 - 6.2e-60 202.4 16.6 6.2e-60 202.4 16.6 2.3 2 0 0 2 2 2 1 Tankyrase binding protein C terminal domain Bac_DnaA_C PF08299.9 NM_001004301.3_1 - 0.00011 22.1 0.1 1 9.3 0.0 3.2 2 0 0 2 2 2 2 Bacterial dnaA protein helix-turn-helix zf-H2C2_2 PF13465.4 NM_001004301.3_1 - 0.013 15.8 26.7 0.55 10.7 0.3 6.0 6 0 0 6 6 6 0 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001004301.3_1 - 0.013 15.8 33.0 0.16 12.3 2.1 5.8 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001004301.3_2 - 2.6e-09 37.0 12.1 9.2e-05 22.6 4.0 4.3 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001004301.3_2 - 4.6e-08 32.9 11.3 5.5e-06 26.4 2.2 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001004301.3_2 - 3.8e-05 24.0 7.7 0.0063 17.1 1.4 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger DZR PF12773.5 NM_001004301.3_2 - 0.046 13.6 0.2 0.09 12.7 0.2 1.5 1 0 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.8 NM_001004301.3_2 - 0.049 13.6 1.5 0.99 9.4 2.2 2.4 1 1 1 2 2 2 0 Zinc ribbon domain zf-met PF12874.5 NM_001004301.3_2 - 0.16 12.2 2.9 0.5 10.7 0.2 2.6 1 1 1 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 NM_001004301.3_2 - 0.25 11.2 4.3 1.4 8.8 0.8 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001004301.3_2 - 0.26 10.9 7.3 0.55 9.9 1.1 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.4 NM_001004301.3_3 - 3.4e-86 280.0 169.0 4.5e-08 33.1 1.2 20.2 20 1 0 20 20 20 15 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001004301.3_3 - 5.9e-55 180.7 185.9 5e-06 26.6 1.6 19.5 20 0 0 20 20 20 16 Zinc finger, C2H2 type KRAB PF01352.25 NM_001004301.3_3 - 2.1e-26 91.2 0.2 3.8e-26 90.3 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001004301.3_3 - 6.5e-23 79.3 170.0 0.014 16.0 1.1 18.6 19 0 0 19 19 19 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001004301.3_3 - 1.9e-15 56.2 138.7 0.0045 16.8 2.5 16.7 17 2 0 17 17 17 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001004301.3_3 - 2.9e-08 33.6 92.7 0.0076 16.2 2.2 13.2 6 3 10 16 16 16 11 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001004301.3_3 - 0.00025 20.6 80.6 0.16 11.7 0.1 14.3 15 0 0 15 15 15 6 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 NM_001004301.3_3 - 0.0038 16.8 0.6 0.0038 16.8 0.6 16.7 17 4 0 17 17 17 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 NM_001004301.3_3 - 3.8 7.8 83.6 2.2 8.6 0.5 15.3 15 0 0 15 15 15 0 Zinc-finger double-stranded RNA-binding DZR PF12773.5 NM_001004301.3_3 - 8.4 6.4 80.0 13 5.8 8.8 8.5 2 1 2 4 4 4 0 Double zinc ribbon zf-H2C2_2 PF13465.4 NM_001102657.1_1 - 2.8e-191 612.2 163.5 4.7e-09 36.2 0.7 26.7 27 0 0 27 27 26 25 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001102657.1_1 - 6.6e-137 438.8 182.2 3.8e-07 30.1 0.3 24.6 24 0 0 24 24 24 24 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001102657.1_1 - 6.2e-75 241.2 169.8 0.0014 19.1 0.2 24.6 24 0 0 24 24 24 24 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001102657.1_1 - 2.8e-45 151.4 142.7 0.0021 17.8 0.3 24.5 24 0 0 24 24 24 20 C2H2-type zinc finger KRAB PF01352.25 NM_001102657.1_1 - 1.4e-24 85.3 0.2 2.7e-24 84.4 0.2 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001102657.1_1 - 3.8e-22 78.0 118.7 0.0031 17.5 1.4 17.7 4 2 21 25 25 24 20 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001102657.1_1 - 1.4e-16 59.8 117.3 0.0067 16.0 0.1 22.0 24 0 0 24 24 24 10 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 NM_001102657.1_1 - 9.2e-14 51.2 93.5 0.018 15.2 0.2 21.0 23 0 0 23 23 23 7 Zinc-finger double-stranded RNA-binding GAGA PF09237.9 NM_001102657.1_1 - 2.2e-10 40.0 36.7 0.069 12.8 0.2 12.0 6 5 5 12 12 12 5 GAGA factor zinc_ribbon_15 PF17032.3 NM_001102657.1_1 - 3.8e-09 37.0 99.1 0.18 12.5 0.9 13.3 1 1 12 13 13 13 8 zinc-ribbon family XPA_N PF01286.16 NM_001102657.1_1 - 4.6e-09 36.0 89.4 0.39 10.7 0.2 22.1 24 0 0 24 24 24 4 XPA protein N-terminal BolA PF01722.16 NM_001102657.1_1 - 1.5e-05 25.0 35.0 2.1 8.5 0.0 10.0 8 2 1 9 9 9 4 BolA-like protein zf-met PF12874.5 NM_001102657.1_1 - 0.00019 21.6 6.7 0.00047 20.3 0.9 18.0 18 0 0 18 18 18 7 Zinc-finger of C2H2 type ADK_lid PF05191.12 NM_001102657.1_1 - 0.0003 20.6 103.2 0.27 11.1 1.0 14.6 10 2 4 14 14 14 6 Adenylate kinase, active site lid Zf_RING PF16744.3 NM_001102657.1_1 - 0.0016 18.4 84.4 1.8 8.6 0.1 18.0 3 3 16 21 21 21 6 KIAA1045 RING finger Endosulfine PF04667.15 NM_207046.1_2 - 2.7e-09 36.9 1.9 4.5e-09 36.2 1.9 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region UPF0054 PF02130.15 NM_001314024.1_2 - 2.5e-08 33.7 0.0 2.9e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 Nuc_N PF14448.4 NM_001314024.1_2 - 0.089 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Nuclease N terminal GAS PF13851.4 NM_001481.2_3 - 5.9e-81 270.5 27.9 5.9e-81 270.5 27.9 2.3 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding PCI PF01399.25 NM_001316354.1_1 - 2.3e-19 69.7 1.6 3.7e-19 69.1 0.2 2.0 2 0 0 2 2 2 1 PCI domain TPR_1 PF00515.26 NM_001316354.1_1 - 0.018 14.8 2.6 0.027 14.2 0.9 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001316354.1_1 - 0.12 12.5 3.2 0.26 11.4 0.9 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.10 NM_001316354.1_1 - 0.12 12.9 1.0 0.29 11.8 1.0 1.7 1 0 0 1 1 1 0 Sel1 repeat TPR_8 PF13181.4 NM_001316354.1_1 - 0.71 10.1 3.5 2.5 8.4 0.4 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Mic1 PF07035.10 NM_013326.4_3 - 8.2e-70 233.5 1.4 1.6e-69 232.6 1.4 1.5 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like Glycos_transf_2 PF00535.24 NM_198321.3_1 - 9.7e-35 119.7 0.0 1.4e-34 119.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 NM_198321.3_1 - 3.7e-27 94.9 1.1 5.8e-27 94.3 1.1 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 NM_198321.3_1 - 2.7e-05 23.6 0.2 5.8e-05 22.5 0.2 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 NM_198321.3_1 - 0.013 14.8 0.0 0.024 14.0 0.0 1.4 1 1 0 1 1 1 0 Glycosyltransferase like family 2 IL7 PF01415.14 NM_001199886.1_2 - 1.2e-23 83.5 8.2 3.4e-13 49.7 0.3 2.3 1 1 0 2 2 2 2 Interleukin 7/9 family CDV3 PF15359.4 NM_001134422.1_3 - 1.8e-41 141.5 6.3 2.8e-41 140.8 6.3 1.3 1 0 0 1 1 1 1 Carnitine deficiency-associated protein 3 zf-CXXC PF02008.18 NM_025212.3_3 - 5.5e-07 29.4 18.9 1.3e-06 28.2 18.9 1.7 1 0 0 1 1 1 1 CXXC zinc finger domain HEAT_2 PF13646.4 NM_031304.4_2 - 3.3e-31 107.4 15.1 1.5e-13 50.8 0.1 3.6 2 2 2 4 4 4 4 HEAT repeats HEAT_PBS PF03130.14 NM_031304.4_2 - 1.7e-20 71.4 23.0 0.00057 20.2 0.0 7.4 7 0 0 7 7 7 5 PBS lyase HEAT-like repeat HEAT PF02985.20 NM_031304.4_2 - 7e-06 25.7 5.4 0.44 10.8 0.2 5.1 5 0 0 5 5 5 2 HEAT repeat Arm PF00514.21 NM_031304.4_2 - 0.006 16.5 0.4 2.2 8.3 0.2 2.7 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 NM_031304.4_2 - 0.049 14.0 8.7 0.12 12.7 0.7 4.2 4 1 1 5 5 5 0 HEAT-like repeat TAF6_C PF07571.11 NM_031304.4_2 - 0.16 12.2 0.0 30 4.9 0.0 2.6 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain Mito_carr PF00153.25 NM_001317232.1_1 - 6.6e-15 54.7 0.1 4.2e-09 36.1 0.0 3.5 3 0 0 3 3 3 2 Mitochondrial carrier protein VWA PF00092.26 NM_002208.4_1 - 2.1e-39 135.5 0.1 4.2e-39 134.5 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_alpha2 PF08441.10 NM_002208.4_1 - 4.2e-25 88.4 0.7 4.2e-25 88.4 0.7 1.5 2 0 0 2 2 2 1 Integrin alpha FG-GAP PF01839.21 NM_002208.4_1 - 1.8e-16 59.8 10.5 3.5e-06 26.9 0.0 3.6 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 NM_002208.4_1 - 1.1e-12 48.4 0.3 3.6e-12 46.8 0.1 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VCBS PF13517.4 NM_002208.4_1 - 6.2e-07 29.8 1.5 0.0007 20.0 0.1 2.6 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 NM_002208.4_1 - 0.00022 20.8 0.8 0.00052 19.7 0.8 1.7 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region BPL_LplA_LipB PF03099.17 NM_015929.3_3 - 0.0025 17.6 0.0 0.0049 16.6 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family RnaseA PF00074.18 NM_001110359.1_1 - 6.6e-21 74.9 2.3 1.4e-20 73.9 2.3 1.6 1 0 0 1 1 1 1 Pancreatic ribonuclease hSH3 PF14603.4 NM_001465.4_2 - 9.2e-51 170.2 23.1 2.4e-42 143.3 1.4 5.1 5 0 0 5 5 5 2 Helically-extended SH3 domain SH3_2 PF07653.15 NM_001465.4_2 - 4e-13 48.7 0.1 2.7e-10 39.6 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 NM_001465.4_2 - 0.00024 20.5 0.3 0.059 12.8 0.0 2.7 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 NM_001465.4_2 - 0.032 13.9 0.1 5.4 6.8 0.0 2.4 2 0 0 2 2 2 0 Variant SH3 domain DUF4651 PF15513.4 NM_001465.4_2 - 0.069 12.8 0.1 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4651) SH3_3 PF08239.9 NM_001465.4_2 - 0.6 10.3 3.1 0.88 9.8 0.1 2.6 3 0 0 3 3 3 0 Bacterial SH3 domain UBN_AB PF14075.4 NM_001465.4_2 - 2.7 7.6 14.2 6.7 6.3 0.8 2.4 2 0 0 2 2 2 0 Ubinuclein conserved middle domain C2 PF00168.28 NM_001320822.1_3 - 1.5e-34 118.2 0.0 7.1e-17 61.5 0.0 3.0 2 1 0 2 2 2 2 C2 domain RasGAP PF00616.17 NM_001320822.1_3 - 3.6e-33 114.9 0.0 2.5e-20 73.0 0.0 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase PH PF00169.27 NM_001320822.1_3 - 1.5e-14 54.2 0.4 1.5e-14 54.2 0.4 2.0 2 0 0 2 2 2 1 PH domain BTK PF00779.17 NM_001320822.1_3 - 1.8e-13 49.9 4.7 4.4e-13 48.7 4.7 1.7 1 0 0 1 1 1 1 BTK motif PH_8 PF15409.4 NM_001320822.1_3 - 0.03 14.5 0.2 0.066 13.4 0.2 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain zf-H2C2_2 PF13465.4 NM_004234.4_2 - 4.4e-112 361.8 129.2 4.2e-09 36.3 0.9 18.7 19 0 0 19 19 19 15 Zinc-finger double domain zf-C2H2 PF00096.24 NM_004234.4_2 - 7.5e-78 252.8 127.0 3.8e-06 26.9 0.3 16.7 16 0 0 16 16 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_004234.4_2 - 8.3e-42 138.1 127.3 0.0036 17.9 0.8 16.9 16 0 0 16 16 16 15 C2H2-type zinc finger KRAB PF01352.25 NM_004234.4_2 - 2.4e-23 81.4 0.1 4.6e-23 80.5 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_004234.4_2 - 6.1e-16 58.1 78.0 0.0019 18.3 0.1 15.7 16 0 0 16 16 16 9 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_004234.4_2 - 1.9e-12 47.0 79.1 0.018 15.0 3.0 10.7 5 4 7 12 12 12 12 Zinc ribbon domain zf-met PF12874.5 NM_004234.4_2 - 2.4e-09 37.1 119.8 0.0045 17.2 0.6 15.4 16 0 0 16 16 16 8 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 NM_004234.4_2 - 1.4e-07 31.2 97.6 0.58 10.0 0.7 15.8 15 0 0 15 15 15 10 C2H2-type zinc finger XPA_N PF01286.16 NM_004234.4_2 - 0.0003 20.6 77.3 2.7 8.0 0.7 15.6 16 0 0 16 16 16 5 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_004234.4_2 - 0.014 16.0 64.3 1.1 9.9 3.0 8.5 1 1 8 10 10 10 0 zinc-ribbon family zf-trcl PF13451.4 NM_004234.4_2 - 0.031 14.0 66.2 0.053 13.3 0.1 12.1 9 4 1 11 11 11 0 Probable zinc-ribbon domain ADK_lid PF05191.12 NM_004234.4_2 - 7.7 6.5 62.5 3.5 7.6 3.1 10.0 4 2 5 9 9 9 0 Adenylate kinase, active site lid Zona_pellucida PF00100.21 NM_001199528.2_1 - 2.3e-38 132.3 5.7 3.1e-38 131.9 3.5 2.1 2 0 0 2 2 2 1 Zona pellucida-like domain EGF_CA PF07645.13 NM_001199528.2_1 - 1.1e-18 67.0 37.4 2.1e-07 30.9 4.3 4.0 4 0 0 4 4 4 3 Calcium-binding EGF domain SEA PF01390.18 NM_001199528.2_1 - 5.1e-14 52.3 8.6 1.2e-08 35.1 0.1 3.7 4 0 0 4 4 4 2 SEA domain WAP PF00095.19 NM_001199528.2_1 - 2.6e-06 27.6 8.8 2.6e-06 27.6 8.8 3.0 3 0 0 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' fn3 PF00041.19 NM_001199528.2_1 - 4.3e-06 26.9 0.1 0.043 14.0 0.0 3.1 2 0 0 2 2 2 2 Fibronectin type III domain EGF_3 PF12947.5 NM_001199528.2_1 - 7.5e-06 25.9 31.5 0.00033 20.7 1.7 4.0 4 0 0 4 4 4 3 EGF domain hEGF PF12661.5 NM_001199528.2_1 - 0.079 13.5 21.7 1.2 9.8 4.4 4.1 3 0 0 3 3 3 0 Human growth factor-like EGF EMI PF07546.11 NM_001199528.2_1 - 0.71 10.5 16.1 0.043 14.4 9.2 2.7 2 0 0 2 2 2 0 EMI domain Plasmod_Pvs28 PF06247.9 NM_001199528.2_1 - 0.92 9.7 12.1 1.3 9.2 0.1 3.9 3 0 0 3 3 3 0 Pvs28 EGF domain Lamp PF01299.15 NM_001199897.1_1 - 4.7e-16 59.1 1.9 6.1e-14 52.1 0.0 2.5 2 1 0 2 2 2 1 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.10 NM_001199897.1_1 - 4.4e-05 23.2 0.0 9.4e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) PDZ PF00595.22 NM_004747.3_2 - 7e-39 131.9 4.4 1.1e-10 41.6 0.3 4.5 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) Takusan PF04822.11 NM_004747.3_2 - 6e-32 109.2 0.3 6e-32 109.2 0.3 5.0 5 0 0 5 5 5 1 Takusan dbPDZ_assoc PF16610.3 NM_004747.3_2 - 5.5e-26 90.5 6.1 5.5e-26 90.5 6.1 2.9 3 0 0 3 3 3 1 Unstructured region between two PDZ domains on Dlg5 PDZ_2 PF13180.4 NM_004747.3_2 - 7.2e-23 80.6 0.2 2.3e-05 24.5 0.0 5.2 5 0 0 5 5 5 4 PDZ domain Guanylate_kin PF00625.19 NM_004747.3_2 - 4.9e-15 55.6 0.5 4.9e-15 55.6 0.5 3.6 4 0 0 4 4 4 1 Guanylate kinase SH3_1 PF00018.26 NM_004747.3_2 - 0.11 11.9 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 SH3 domain CARD PF00619.19 NM_004747.3_2 - 0.19 11.7 10.3 0.089 12.7 0.5 3.8 3 0 0 3 3 3 0 Caspase recruitment domain fn3 PF00041.19 NM_001127671.1_3 - 2.1e-18 66.3 7.9 3.2e-05 24.1 0.2 6.5 7 0 0 7 7 7 5 Fibronectin type III domain EpoR_lig-bind PF09067.8 NM_001127671.1_3 - 0.00013 22.0 0.2 0.33 11.0 0.2 2.6 2 0 0 2 2 2 2 Erythropoietin receptor, ligand binding Pur_ac_phosph_N PF16656.3 NM_001127671.1_3 - 0.002 18.6 0.3 0.0073 16.7 0.2 2.0 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain IL6Ra-bind PF09240.8 NM_001127671.1_3 - 0.0031 17.8 3.7 1.2 9.5 0.0 3.3 3 0 0 3 3 3 2 Interleukin-6 receptor alpha chain, binding DHFR_1 PF00186.17 NM_000791.3_1 - 1.6e-31 109.1 0.0 2.2e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 Dihydrofolate reductase Pannexin_like PF12534.6 NM_001127245.1_1 - 3.1e-144 480.3 1.8 4.1e-144 479.8 1.8 1.2 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.4 NM_001127245.1_1 - 2e-27 94.6 40.8 1.1e-09 37.7 1.9 6.8 5 2 0 6 6 6 4 Leucine rich repeat LRR_4 PF12799.5 NM_001127245.1_1 - 4.8e-25 87.0 44.2 5e-05 23.4 1.6 9.5 7 3 2 9 9 9 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_001127245.1_1 - 1.6e-08 34.4 0.9 5.8e-05 22.9 0.9 3.1 1 1 3 4 4 4 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_001127245.1_1 - 1e-06 28.2 17.8 0.00041 19.8 1.6 3.4 1 1 2 3 3 3 3 Leucine-rich repeat Asp PF00026.21 NM_001909.4_2 - 2.7e-119 398.1 0.0 3.8e-119 397.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 NM_001909.4_2 - 1.7e-13 51.1 1.1 2.9e-11 43.8 1.1 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 NM_001909.4_2 - 2.2e-09 36.8 0.0 3.8e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.4 NM_001909.4_2 - 4.9e-06 26.3 0.0 9.7e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal CLN5 PF15014.4 NM_006493.2_2 - 5.1e-171 568.0 6.6 6.2e-171 567.7 6.6 1.1 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 5 zf-BED PF02892.13 NM_014838.2_3 - 3.3e-61 203.0 28.1 1e-15 57.3 0.4 4.7 4 0 0 4 4 4 4 BED zinc finger Dimer_Tnp_hAT PF05699.12 NM_014838.2_3 - 1.4e-07 31.0 0.0 4.1e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region PyrI_C PF02748.13 NM_014838.2_3 - 0.0011 18.6 4.8 8.3 6.3 0.1 4.4 4 0 0 4 4 4 3 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_9 PF14369.4 NM_014838.2_3 - 2.2 8.4 5.4 92 3.3 0.0 4.7 4 0 0 4 4 4 0 zinc-ribbon zf-C2H2_4 PF13894.4 NM_032434.3_1 - 1.8e-07 31.3 35.1 0.013 16.2 2.5 6.9 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_032434.3_1 - 4.3e-07 29.9 27.9 0.0018 18.5 2.3 6.2 6 0 0 6 6 6 3 Zinc finger, C2H2 type CpXC PF14353.4 NM_032434.3_1 - 2.8e-06 27.2 6.7 0.024 14.6 0.0 3.6 3 1 0 3 3 3 2 CpXC protein zf-C2H2_jaz PF12171.6 NM_032434.3_1 - 0.0012 18.9 10.7 0.023 14.9 1.3 4.5 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.13 NM_032434.3_1 - 0.02 14.8 27.6 3.3 7.7 3.2 5.7 4 2 1 5 5 5 0 BED zinc finger zf-C2HE PF16278.3 NM_032434.3_1 - 0.027 14.8 21.4 0.58 10.5 4.1 5.1 4 2 0 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.5 NM_032434.3_1 - 0.039 14.2 20.0 0.49 10.6 0.8 4.8 2 2 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_aberr PF17017.3 NM_032434.3_1 - 0.066 13.2 16.2 2.9 7.8 0.3 3.9 3 1 1 4 4 4 0 Aberrant zinc-finger zf-met PF12874.5 NM_032434.3_1 - 1.4 9.2 12.3 2 8.8 0.3 4.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zinc_ribbon_2 PF13240.4 NM_032434.3_1 - 9.1 6.0 11.6 16 5.2 0.4 4.2 4 0 0 4 4 4 0 zinc-ribbon domain APG6 PF04111.10 NM_152492.2_1 - 0.006 15.9 23.9 0.006 15.9 23.9 3.0 1 1 1 2 2 2 1 Autophagy protein Apg6 AAA_13 PF13166.4 NM_152492.2_1 - 0.024 13.2 22.4 0.039 12.5 22.4 1.2 1 0 0 1 1 1 0 AAA domain NPV_P10 PF05531.10 NM_152492.2_1 - 0.56 10.6 15.8 0.33 11.3 4.4 3.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF745 PF05335.11 NM_152492.2_1 - 1.8 8.1 24.6 3.8 7.1 5.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF745) PKcGMP_CC PF16808.3 NM_152492.2_1 - 2.7 7.8 19.4 0.71 9.6 0.3 4.2 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Baculo_PEP_C PF04513.10 NM_152492.2_1 - 4.9 7.1 18.9 6.5 6.7 4.1 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.10 NM_152492.2_1 - 6.5 5.9 8.8 1.2 8.4 2.5 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein SlyX PF04102.10 NM_152492.2_1 - 6.7 7.3 39.1 0.3 11.6 6.9 4.5 4 0 0 4 4 4 0 SlyX Spc7 PF08317.9 NM_152492.2_1 - 9.4 4.9 36.8 1.5 7.5 29.4 2.6 2 1 0 2 2 2 0 Spc7 kinetochore protein MTCP1 PF08991.8 NM_001011668.2_2 - 0.0091 16.1 0.7 0.021 14.9 0.7 1.6 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type DDE_1 PF03184.17 NM_001243253.1_1 - 7.2e-41 139.5 0.8 1.4e-40 138.6 0.8 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 NM_001243253.1_1 - 8.6e-16 57.6 0.0 1.6e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.11 NM_001243253.1_1 - 9.5e-11 41.0 0.1 1.7e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_1 PF01527.18 NM_001243253.1_1 - 0.00073 19.7 0.2 0.0017 18.5 0.2 1.6 1 0 0 1 1 1 1 Transposase HTH_28 PF13518.4 NM_001243253.1_1 - 0.001 19.0 0.0 0.011 15.7 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.4 NM_001243253.1_1 - 0.002 17.8 0.0 0.011 15.3 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain Filament PF00038.19 NM_004138.3_1 - 5.6e-107 357.8 40.7 6.4e-107 357.6 40.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 NM_004138.3_1 - 0.026 14.5 40.8 0.04 13.9 4.3 4.0 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein zf-C4H2 PF10146.7 NM_004138.3_1 - 0.12 12.5 24.7 0.36 10.9 1.7 3.5 1 1 0 3 3 3 0 Zinc finger-containing protein DUF1664 PF07889.10 NM_004138.3_1 - 0.55 10.1 17.6 2.2 8.1 1.1 3.7 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 NM_004138.3_1 - 1.6 8.6 25.2 1.7 8.5 2.2 3.5 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.8 NM_004138.3_1 - 2 8.5 27.1 0.82 9.7 11.9 3.7 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family NYD-SP28_assoc PF14775.4 NM_004138.3_1 - 2.4 8.2 17.8 1.1 9.2 1.2 4.5 3 2 0 3 3 3 0 Sperm tail C-terminal domain Prefoldin PF02996.15 NM_004138.3_1 - 3.8 7.3 21.4 1.8 8.4 1.6 4.8 4 2 0 4 4 4 0 Prefoldin subunit DUF4359 PF14271.4 NM_004138.3_1 - 5.2 7.8 7.3 27 5.4 0.3 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4359) Ribosomal_L10 PF00466.18 NM_053275.3_1 - 5.1e-22 77.7 0.0 9.6e-22 76.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.17 NM_053275.3_1 - 1.9e-20 73.1 5.2 1.9e-20 73.1 5.2 1.8 2 0 0 2 2 2 1 60s Acidic ribosomal protein His_Phos_2 PF00328.20 NM_001190214.1_1 - 4e-135 450.9 1.6 7.9e-135 450.0 0.0 1.9 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.9 NM_001190214.1_1 - 0.051 13.0 0.0 0.096 12.1 0.0 1.3 1 0 0 1 1 1 0 RimK-like ATP-grasp domain zf-C3HC4_2 PF13923.4 NM_005802.4_1 - 7.2e-11 41.6 8.6 1.6e-10 40.5 8.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_005802.4_1 - 1.9e-09 37.1 5.6 1.9e-09 37.1 5.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_005802.4_1 - 6.7e-09 35.7 9.2 1.7e-08 34.4 9.2 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 NM_005802.4_1 - 7.1e-09 35.3 7.9 7.1e-09 35.3 7.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_005802.4_1 - 8.2e-07 28.8 2.5 8.2e-07 28.8 2.5 2.3 2 1 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.5 NM_005802.4_1 - 2e-05 24.6 5.6 6.1e-05 23.1 5.6 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.4 NM_005802.4_1 - 6.3e-05 22.9 8.5 0.00017 21.5 8.5 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 NM_005802.4_1 - 0.00015 21.5 8.6 0.00015 21.5 8.6 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 NM_005802.4_1 - 0.0049 16.7 3.1 0.011 15.7 3.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.12 NM_005802.4_1 - 0.031 14.0 1.0 0.33 10.7 0.1 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif Prok-RING_4 PF14447.4 NM_005802.4_1 - 0.061 13.1 14.6 0.049 13.4 10.0 2.8 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 NM_005802.4_1 - 0.18 11.4 9.5 0.48 10.1 9.5 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.12 NM_005802.4_1 - 2.3 7.8 6.7 5.7 6.6 6.7 1.6 1 0 0 1 1 1 0 P-11 zinc finger Ig_2 PF13895.4 NM_001288830.1_3 - 3.6e-20 72.0 0.0 1.8e-10 40.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001288830.1_3 - 1.2e-07 32.1 0.3 0.0027 18.2 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin domain DUF4195 PF13836.4 NM_001002844.2_3 - 1.9e-40 138.8 9.7 1.9e-40 138.8 9.7 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4195) HDAC4_Gln PF12203.6 NM_001321885.1_2 - 7.2e-35 118.9 46.9 7.2e-35 118.9 46.9 3.6 4 0 0 4 4 4 1 Glutamine rich N terminal domain of histone deacetylase 4 Fibrinogen_C PF00147.16 NM_001147.2_3 - 7.1e-68 228.6 7.8 1e-67 228.0 7.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4710 PF15828.3 NM_001147.2_3 - 0.1 12.6 3.1 0.28 11.2 3.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) SlyX PF04102.10 NM_001147.2_3 - 4.4 7.9 19.1 1.2 9.7 5.6 2.8 1 1 1 2 2 2 0 SlyX DivIC PF04977.13 NM_001147.2_3 - 9.9 5.9 15.9 1.5 8.5 4.0 3.0 1 1 1 3 3 3 0 Septum formation initiator p53-inducible11 PF14936.4 NM_001258321.1_2 - 3e-85 284.7 1.3 3.8e-85 284.4 1.3 1.1 1 0 0 1 1 1 1 Tumour protein p53-inducible protein 11 STAT_bind PF02864.13 NM_001243835.1_1 - 1.5e-73 247.6 0.4 1.5e-73 247.6 0.4 2.1 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 NM_001243835.1_1 - 2.9e-53 180.3 14.2 2.9e-53 180.3 14.2 1.7 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 NM_001243835.1_1 - 5.2e-38 130.1 4.7 5.2e-38 130.1 4.7 3.1 2 1 2 4 4 4 1 STAT protein, protein interaction domain SH2 PF00017.22 NM_001243835.1_1 - 2.3e-11 43.4 0.0 1e-10 41.4 0.0 2.2 2 0 0 2 2 2 1 SH2 domain CRC_subunit PF08624.8 NM_001243835.1_1 - 0.12 12.7 2.1 0.3 11.4 2.1 1.6 1 0 0 1 1 1 0 Chromatin remodelling complex Rsc7/Swp82 subunit NPV_P10 PF05531.10 NM_001243835.1_1 - 0.33 11.3 5.0 0.45 10.9 2.2 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Sdh_cyt PF01127.20 NM_001035513.1_1 - 2.1e-19 69.6 1.4 4.3e-19 68.6 1.4 1.5 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Josephin PF02099.15 NM_138334.3_1 - 2.5e-26 92.5 0.0 6.7e-25 87.9 0.0 2.0 1 1 0 1 1 1 1 Josephin zf-C2H2 PF00096.24 NM_003413.3_2 - 2.3e-19 68.6 31.8 1.2e-05 25.4 3.0 6.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_003413.3_2 - 1.7e-16 59.6 29.5 2.5e-06 27.5 0.3 5.5 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_jaz PF12171.6 NM_003413.3_2 - 1.2e-05 25.3 15.5 0.028 14.6 0.2 5.7 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_003413.3_2 - 0.0014 18.8 1.2 0.0014 18.8 1.2 4.7 5 0 0 5 5 5 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 NM_003413.3_2 - 0.0018 18.8 6.4 0.0055 17.3 1.8 7.3 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_003413.3_2 - 0.005 16.6 1.1 0.005 16.6 1.1 4.2 4 0 0 4 4 4 1 C2H2-type zinc finger PE PF00934.18 NM_003413.3_2 - 0.11 12.7 4.7 0.2 11.9 4.7 1.3 1 0 0 1 1 1 0 PE family zf-C2H2_8 PF15909.3 NM_003413.3_2 - 3.4 7.9 18.5 0.81 9.9 3.8 3.6 3 1 2 5 5 5 0 C2H2-type zinc ribbon Tuberin PF03542.14 NM_000548.4_3 - 3.7e-145 483.4 0.0 7.8e-145 482.3 0.0 1.6 1 0 0 1 1 1 1 Tuberin DUF3384 PF11864.6 NM_000548.4_3 - 1.1e-92 311.3 7.0 7e-92 308.7 7.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.13 NM_000548.4_3 - 9.7e-43 145.8 0.0 1.8e-42 144.9 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Cnd1 PF12717.5 NM_000548.4_3 - 0.1 12.4 3.7 0.15 11.9 0.1 3.0 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 NM_000548.4_3 - 0.13 12.5 0.1 2.4 8.5 0.0 3.1 2 0 0 2 2 2 0 HEAT repeat Telomere_reg-2 PF10193.7 NM_000548.4_3 - 0.79 10.0 3.5 0.94 9.8 0.4 2.9 3 0 0 3 3 3 0 Telomere length regulation protein TMC PF07810.11 NM_001324263.1_1 - 1.4e-49 167.1 3.0 1.4e-49 167.1 3.0 2.1 2 0 0 2 2 2 1 TMC domain Myb_DNA-binding PF00249.29 NM_001142326.1_3 - 1.1e-28 99.0 12.2 3.6e-19 68.5 0.6 4.4 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 NM_001142326.1_3 - 2.9e-16 59.3 4.3 8.3e-09 35.4 0.1 4.1 3 1 1 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.4 NM_001142326.1_3 - 0.25 11.6 5.8 0.099 12.9 0.4 3.0 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain Serpin PF00079.18 NM_001101320.1_1 - 3.4e-81 273.3 0.0 5.7e-81 272.6 0.0 1.2 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) MHC2-interact PF09307.8 NM_004355.3_2 - 2.2e-39 133.7 1.7 3.8e-39 132.9 1.7 1.4 1 0 0 1 1 1 1 CLIP, MHC2 interacting MHCassoc_trimer PF08831.8 NM_004355.3_2 - 1e-33 115.0 4.3 1.7e-33 114.3 4.3 1.4 1 0 0 1 1 1 1 Class II MHC-associated invariant chain trimerisation domain Torsin PF06309.9 NM_022371.3_3 - 3e-58 195.3 0.1 5.7e-58 194.4 0.1 1.5 1 0 0 1 1 1 1 Torsin AAA_22 PF13401.4 NM_022371.3_3 - 0.0013 18.8 0.1 0.23 11.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.27 NM_022371.3_3 - 0.064 13.5 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.16 NM_022371.3_3 - 0.14 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase WD40 PF00400.30 NM_024102.3_2 - 1.4e-06 28.8 20.4 4.7e-05 23.9 0.1 6.3 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_024102.3_2 - 0.00077 19.6 1.3 0.038 14.2 0.0 3.3 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.6 NM_024102.3_2 - 0.0021 16.3 0.2 0.0029 15.8 0.2 1.1 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz Cation_efflux PF01545.19 NM_133496.4_3 - 9.6e-43 146.1 10.6 1.6e-42 145.4 10.6 1.4 1 0 0 1 1 1 1 Cation efflux family zf-C2H2_4 PF13894.4 NM_153034.2_1 - 0.02 15.5 20.7 0.092 13.5 5.1 4.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_9 PF16293.3 NM_153034.2_1 - 0.32 10.7 4.7 0.72 9.6 0.8 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.5 NM_153034.2_1 - 0.79 10.0 9.1 2.3 8.5 2.5 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.24 NM_153034.2_1 - 5 7.7 23.8 0.33 11.4 5.5 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type SPRY PF00622.26 NM_207344.3_1 - 1e-06 28.7 0.0 1.7e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_207344.3_1 - 9.3e-06 25.0 0.0 1.9e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 SPRY-associated domain EMI PF07546.11 NM_007046.3_2 - 2.8e-14 53.5 10.0 5.2e-14 52.6 10.0 1.5 1 0 0 1 1 1 1 EMI domain C1q PF00386.19 NM_007046.3_2 - 7.6e-11 42.2 0.0 3.7e-10 40.0 0.0 1.9 1 1 0 1 1 1 1 C1q domain Collagen PF01391.16 NM_007046.3_2 - 1.5e-08 34.1 28.4 1.5e-08 34.1 28.4 4.1 3 0 0 3 3 2 1 Collagen triple helix repeat (20 copies) DUF1664 PF07889.10 NM_007046.3_2 - 0.0071 16.2 2.4 12 5.8 0.4 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) FlxA PF14282.4 NM_007046.3_2 - 0.02 14.7 2.3 1.4 8.8 0.0 3.3 3 0 0 3 3 3 0 FlxA-like protein HAUS-augmin3 PF14932.4 NM_007046.3_2 - 0.076 12.4 2.2 0.92 8.8 0.5 2.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Reo_sigmaC PF04582.10 NM_007046.3_2 - 0.093 12.0 5.1 0.71 9.1 0.3 3.5 3 1 1 4 4 4 0 Reovirus sigma C capsid protein TRAF_BIRC3_bd PF16673.3 NM_007046.3_2 - 0.45 10.2 5.2 26 4.6 0.3 4.4 4 0 0 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain COG2 PF06148.9 NM_007046.3_2 - 0.57 10.1 5.2 28 4.7 0.1 4.2 5 0 0 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 Filament PF00038.19 NM_007046.3_2 - 0.8 9.1 5.3 4 6.8 0.7 2.5 2 0 0 2 2 2 0 Intermediate filament protein DUF4407 PF14362.4 NM_007046.3_2 - 1 8.5 11.6 4 6.6 0.8 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) Bacillus_HBL PF05791.9 NM_007046.3_2 - 1.4 8.5 3.5 11 5.6 0.2 2.9 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Med9 PF07544.11 NM_007046.3_2 - 1.5 8.9 5.8 20 5.2 0.0 3.8 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 FlaC_arch PF05377.9 NM_007046.3_2 - 1.5 9.1 3.7 87 3.5 0.1 4.6 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) Mnd1 PF03962.13 NM_007046.3_2 - 4.4 7.0 6.2 35 4.0 2.3 2.8 2 1 0 2 2 2 0 Mnd1 family Helo_like_N PF17111.3 NM_007046.3_2 - 6.4 5.9 6.6 10 5.3 0.2 3.7 3 1 0 3 3 3 0 Fungal N-terminal domain of STAND proteins Glyco_hydro_56 PF01630.16 NM_153189.2_2 - 8.8e-136 452.2 0.0 1.1e-135 451.9 0.0 1.1 1 0 0 1 1 1 1 Hyaluronidase DUF2180 PF09947.7 NM_153189.2_2 - 0.066 13.1 0.2 0.16 11.9 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) TPR_1 PF00515.26 NM_022110.3_1 - 5.6e-18 63.8 1.5 2.4e-07 30.1 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 NM_022110.3_1 - 3.1e-14 51.7 5.4 5.5e-06 26.0 0.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.4 NM_022110.3_1 - 1.6e-09 37.6 7.1 0.0002 21.8 0.5 3.7 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_022110.3_1 - 9e-08 32.4 4.4 2e-05 24.9 1.9 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_022110.3_1 - 9.1e-08 32.5 7.3 0.00012 22.6 1.1 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_022110.3_1 - 1.3e-07 31.5 6.3 7.1e-07 29.2 0.7 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.4 NM_022110.3_1 - 1.1e-06 28.2 0.1 0.00061 19.7 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_022110.3_1 - 1.3e-06 27.9 0.3 0.00034 20.1 0.2 2.5 2 0 0 2 2 2 1 TPR repeat TPR_6 PF13174.4 NM_022110.3_1 - 1.5e-05 25.2 1.9 0.078 13.5 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_022110.3_1 - 5.2e-05 23.3 4.1 0.0024 18.0 1.1 2.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_022110.3_1 - 0.00011 21.8 0.2 7.4 6.7 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.4 NM_022110.3_1 - 0.00029 20.9 0.5 0.18 12.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_022110.3_1 - 0.0012 18.7 0.3 0.023 14.6 0.1 2.4 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.15 NM_022110.3_1 - 0.019 15.3 5.5 4.4 7.6 3.1 3.2 2 1 0 2 2 2 0 Bacterial transcriptional activator domain TPR_4 PF07721.12 NM_022110.3_1 - 0.45 11.2 11.6 12 6.7 0.5 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_022110.3_1 - 5.5 6.9 6.4 12 5.8 0.2 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat 7tm_4 PF13853.4 NM_001004137.1_1 - 5.2e-107 357.6 17.5 6.5e-107 357.3 17.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004137.1_1 - 6.3e-15 55.0 20.9 5.1e-14 52.0 20.9 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001004137.1_1 - 3.6e-08 33.0 6.1 3.6e-08 33.0 6.1 1.7 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx CybS PF05328.10 NM_001004137.1_1 - 2.6 7.6 7.2 0.43 10.1 2.6 2.1 2 0 0 2 2 2 0 CybS, succinate dehydrogenase cytochrome B small subunit ABC_tran PF00005.25 NM_152701.4_1 - 1.4e-51 174.4 0.0 3.2e-28 98.8 0.3 3.2 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.5 NM_152701.4_1 - 8.9e-42 143.3 38.5 1.2e-28 100.2 12.0 4.6 5 0 0 5 5 5 2 ABC-2 family transporter protein AAA_21 PF13304.4 NM_152701.4_1 - 5e-15 56.0 12.8 3.9e-05 23.5 0.0 6.4 7 0 0 7 7 7 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 NM_152701.4_1 - 0.0026 17.3 4.1 0.097 12.3 0.2 3.1 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_23 PF13476.4 NM_152701.4_1 - 0.013 15.9 0.0 0.013 15.9 0.0 5.4 5 0 0 5 5 5 0 AAA domain DUF258 PF03193.14 NM_152701.4_1 - 0.014 15.2 1.1 0.45 10.3 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF4637 PF15470.4 NM_152701.4_1 - 0.15 11.8 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) AAA_22 PF13401.4 NM_152701.4_1 - 0.28 11.3 2.7 8.3 6.6 0.0 4.9 3 0 0 3 3 3 0 AAA domain Solute_trans_a PF03619.14 NM_018241.2_3 - 5.6e-103 343.9 20.3 5.6e-103 343.9 20.3 1.4 2 0 0 2 2 2 1 Organic solute transporter Ostalpha CD20 PF04103.13 NM_001031809.1_3 - 9.3e-20 71.1 8.9 1.5e-19 70.5 8.9 1.3 1 0 0 1 1 1 1 CD20-like family Complex1_LYR PF05347.13 NM_001302835.1_2 - 1e-11 44.6 0.1 2.1e-11 43.6 0.1 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) cNMP_binding PF00027.27 NM_001164760.1_2 - 9.4e-41 137.6 0.0 6.4e-20 70.8 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 NM_001164760.1_2 - 1.2e-13 50.4 0.0 2.1e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Hydin_ADK PF17213.1 NM_001164760.1_2 - 0.27 11.4 1.8 0.49 10.5 1.8 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Pax2_C PF12403.6 NM_003988.4_1 - 8.1e-22 77.3 6.7 2.1e-21 76.0 6.7 1.7 1 0 0 1 1 1 1 Paired-box protein 2 C terminal PAX PF00292.16 NM_003988.4_2 - 2.3e-74 247.2 0.5 3.5e-74 246.6 0.5 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 NM_003988.4_2 - 1.1e-23 83.3 10.8 4.6e-23 81.3 10.8 2.0 1 1 0 1 1 1 1 Paired-box protein 2 C terminal HTH_23 PF13384.4 NM_003988.4_2 - 0.00047 19.8 0.0 0.0011 18.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain Homeobox PF00046.27 NM_003988.4_2 - 0.037 13.7 0.1 0.078 12.7 0.1 1.4 1 0 0 1 1 1 0 Homeobox domain HTH_28 PF13518.4 NM_003988.4_2 - 0.043 13.8 0.3 0.15 12.0 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_32 PF13565.4 NM_003988.4_2 - 0.081 13.4 0.0 0.081 13.4 0.0 5.0 7 1 1 8 8 8 0 Homeodomain-like domain E1-E2_ATPase PF00122.18 NM_001256214.1_3 - 2.8e-58 196.7 2.9 5.4e-58 195.8 2.9 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 NM_001256214.1_3 - 2.2e-44 151.2 1.9 2.9e-44 150.8 0.2 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 NM_001256214.1_3 - 1.5e-24 85.8 0.0 3.5e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 NM_001256214.1_3 - 6.9e-19 68.8 0.2 1.3e-15 58.1 0.2 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 NM_001256214.1_3 - 1.3e-18 66.3 0.0 2.7e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 NM_001256214.1_3 - 7.9e-06 25.6 0.9 0.00092 18.9 0.5 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DNA_methylase PF00145.15 NM_175850.2_1 - 1.5e-15 57.2 0.0 2.7e-11 43.3 0.0 2.2 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase PWWP PF00855.15 NM_175850.2_1 - 1.1e-12 48.1 0.6 2.3e-12 47.1 0.6 1.5 1 0 0 1 1 1 1 PWWP domain PA_decarbox PF05870.9 NM_175850.2_1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Phenolic acid decarboxylase (PAD) Sulfotransfer_1 PF00685.25 NM_021615.4_1 - 3.7e-20 72.4 0.0 5.1e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_021615.4_1 - 1.2e-12 48.6 0.0 1.4e-11 45.1 0.0 2.3 1 1 0 1 1 1 1 Sulfotransferase family WD40 PF00400.30 NM_001267805.1_2 - 4.4e-19 68.3 9.4 1.1e-06 29.1 0.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001267805.1_2 - 0.043 14.0 0.1 34 4.7 0.0 3.6 3 2 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain RAWUL PF16207.3 NM_032373.4_2 - 3.3e-12 46.7 0.0 1e-11 45.2 0.0 1.9 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 NM_032373.4_2 - 9.8e-09 34.8 10.8 9.8e-09 34.8 10.8 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_032373.4_2 - 5e-07 29.4 14.1 8.6e-07 28.6 11.5 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_032373.4_2 - 0.00022 21.0 9.2 0.0018 18.1 9.2 2.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_032373.4_2 - 0.00032 20.5 8.7 0.00032 20.5 8.7 3.3 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 NM_032373.4_2 - 0.0016 18.5 10.4 0.0016 18.5 10.4 3.4 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 NM_032373.4_2 - 0.0034 17.5 9.5 0.0034 17.5 9.5 3.3 2 0 0 2 2 2 1 Ring finger domain zf-Nse PF11789.6 NM_032373.4_2 - 0.041 13.6 6.4 0.094 12.4 6.4 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.4 NM_032373.4_2 - 0.32 10.7 16.1 0.0082 15.9 8.0 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Sec2p PF06428.9 NM_001024647.3_3 - 1.2e-08 34.7 6.4 2.2e-08 33.8 6.4 1.4 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p MIF4G PF02854.17 NM_001042559.2_1 - 1.9e-57 194.2 2.3 1.9e-57 194.2 2.3 1.9 2 0 0 2 2 2 1 MIF4G domain W2 PF02020.16 NM_001042559.2_1 - 2.5e-20 72.2 1.1 7.1e-20 70.8 1.1 1.8 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon MA3 PF02847.15 NM_001042559.2_1 - 6.6e-17 61.4 0.1 6.6e-17 61.4 0.1 2.8 3 0 0 3 3 3 1 MA3 domain Cadherin PF00028.15 NM_001300828.1_3 - 2.4e-82 271.3 3.4 5.2e-17 61.9 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_001300828.1_3 - 1.9e-14 53.1 0.1 3.9e-13 48.9 0.1 3.1 3 0 0 3 3 3 1 Cadherin-like Cadherin_3 PF16184.3 NM_001300828.1_3 - 3.1e-05 23.8 4.5 0.8 9.6 0.0 5.1 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 NM_001300828.1_3 - 0.0041 17.7 0.3 0.0041 17.7 0.3 2.3 2 1 0 2 2 2 1 Cadherin cytoplasmic C-terminal BBS1 PF14779.4 NM_001300828.1_3 - 0.015 14.6 0.0 0.028 13.7 0.0 1.4 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 TMEM154 PF15102.4 NM_001300828.1_3 - 0.072 12.9 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family DUF3418 PF11898.6 NM_001300828.1_3 - 0.18 10.3 0.0 0.27 9.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) Collagen PF01391.16 NM_000494.3_2 - 2.1e-49 165.0 413.7 2.3e-09 36.7 30.1 18.7 12 3 7 19 19 19 17 Collagen triple helix repeat (20 copies) DUF2868 PF11067.6 NM_000494.3_2 - 0.35 10.2 5.5 0.6 9.4 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Mito_carr PF00153.25 NM_001317812.1_2 - 1.8e-60 200.7 4.4 1.9e-20 72.4 0.1 3.4 2 1 1 3 3 3 3 Mitochondrial carrier protein START PF01852.17 NM_178007.2_1 - 1.5e-40 138.7 0.1 2.5e-40 138.0 0.1 1.3 1 0 0 1 1 1 1 START domain RhoGAP PF00620.25 NM_178007.2_1 - 1.6e-36 125.2 2.5 2.8e-36 124.5 2.5 1.3 1 0 0 1 1 1 1 RhoGAP domain SAM_2 PF07647.15 NM_178007.2_1 - 1.7e-05 24.7 0.0 4.5e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) ISK_Channel PF02060.13 NM_012282.2_1 - 0.00036 20.1 0.0 0.00065 19.3 0.0 1.3 1 0 0 1 1 1 1 Slow voltage-gated potassium channel Homeobox PF00046.27 NM_001177479.1_2 - 1e-09 38.0 2.3 0.00034 20.2 0.0 2.5 2 0 0 2 2 2 2 Homeobox domain Ras PF00071.20 NM_018890.3_2 - 7.9e-49 165.2 0.0 8.3e-26 90.4 0.0 2.1 1 1 0 2 2 2 2 Ras family Roc PF08477.11 NM_018890.3_2 - 2.5e-17 63.1 0.0 1.8e-11 44.2 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_018890.3_2 - 0.00019 20.8 0.0 0.0057 16.0 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family Neuregulin PF02158.13 NM_001159999.2_3 - 1.4e-189 630.5 21.4 1.4e-189 630.5 21.4 1.6 2 0 0 2 2 2 1 Neuregulin family I-set PF07679.14 NM_001159999.2_3 - 1e-12 47.8 0.0 2.4e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001159999.2_3 - 8.4e-11 42.2 0.0 2.7e-10 40.6 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 NM_001159999.2_3 - 1.4e-09 37.8 0.0 3.2e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_001159999.2_3 - 3.5e-07 30.3 0.2 1e-06 28.8 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 NM_001159999.2_3 - 9.1e-05 22.4 0.4 0.00056 19.9 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin V-set domain EGF PF00008.25 NM_001159999.2_3 - 0.0023 18.1 2.9 0.0058 16.8 2.9 1.8 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.11 NM_001159999.2_3 - 1.4 9.2 4.9 4 7.8 4.9 1.8 1 0 0 1 1 1 0 EGF-like domain DUF1049 PF06305.9 NM_001159999.2_3 - 3.8 7.3 7.3 14 5.5 0.7 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) adh_short PF00106.23 NM_181755.2_1 - 6.6e-53 178.9 4.2 8.8e-53 178.5 4.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_181755.2_1 - 7.6e-24 84.4 2.7 9.5e-24 84.1 2.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_181755.2_1 - 1.3e-08 34.9 2.0 2.6e-08 33.9 2.0 1.4 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.17 NM_181755.2_1 - 0.001 18.3 0.1 0.0018 17.5 0.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.8 NM_181755.2_1 - 0.0026 17.1 0.1 0.013 14.8 0.0 1.8 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) 2-Hacid_dh_C PF02826.17 NM_181755.2_1 - 0.031 13.5 0.1 0.05 12.8 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.4 NM_181755.2_1 - 0.032 13.3 0.0 0.044 12.9 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.18 NM_181755.2_1 - 0.034 14.1 0.1 0.056 13.4 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.12 NM_181755.2_1 - 0.042 13.0 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.13 NM_181755.2_1 - 0.045 13.8 0.1 0.078 13.0 0.1 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase PDZ PF00595.22 NM_001303513.1_3 - 1.1e-16 60.8 1.5 2.4e-13 50.1 0.1 2.5 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001303513.1_3 - 3.8e-07 30.2 0.0 2.6e-06 27.5 0.1 2.1 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.4 NM_001303513.1_3 - 0.0086 15.9 0.0 0.024 14.5 0.0 1.7 1 0 0 1 1 1 1 Tricorn protease PDZ domain Sulfotransfer_1 PF00685.25 NM_005114.2_3 - 1.2e-39 136.3 0.0 1.6e-39 135.8 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_005114.2_3 - 2.1e-14 54.3 0.4 2.3e-09 37.8 0.3 2.2 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.12 NM_005114.2_3 - 0.0071 16.1 0.6 0.019 14.7 0.6 1.7 1 1 0 1 1 1 1 Sulfotransferase family Mitofilin PF09731.7 NM_001100170.1_2 - 9.9e-208 691.8 38.9 1.2e-207 691.5 38.9 1.0 1 0 0 1 1 1 1 Mitochondrial inner membrane protein SpoVS PF04232.10 NM_001100170.1_2 - 0.27 10.9 2.6 0.92 9.2 2.6 1.9 1 0 0 1 1 1 0 Stage V sporulation protein S (SpoVS) Pkinase PF00069.23 NM_016508.3_3 - 1.9e-74 250.2 0.1 2.6e-74 249.8 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_016508.3_3 - 5.7e-39 133.8 0.0 2.3e-38 131.8 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_016508.3_3 - 3.7e-07 29.6 0.0 1.2e-06 27.9 0.0 1.7 1 1 1 2 2 2 1 Kinase-like FTA2 PF13095.4 NM_016508.3_3 - 9.3e-05 22.0 0.4 0.059 12.9 0.0 2.3 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 NM_016508.3_3 - 9.4e-05 21.7 0.6 0.00016 21.0 0.6 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 NM_016508.3_3 - 0.00039 20.0 0.1 0.00068 19.2 0.1 1.3 1 0 0 1 1 1 1 RIO1 family MdcG PF10620.7 NM_016508.3_3 - 0.0025 17.5 0.0 0.0041 16.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl-dephospho-CoA transferase MdcG APH PF01636.21 NM_016508.3_3 - 0.046 13.5 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family 7tm_1 PF00001.19 NM_001286099.1_1 - 8.1e-31 107.1 10.7 1.5e-30 106.2 10.7 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_001286099.1_1 - 6e-07 29.3 5.4 0.00036 20.2 3.4 2.4 2 1 0 2 2 2 2 Olfactory receptor Pkinase_Tyr PF07714.15 NM_001014796.1_1 - 3.8e-85 285.2 0.0 5.1e-85 284.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001014796.1_1 - 1.9e-42 145.3 0.0 1.6e-41 142.3 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 NM_001014796.1_1 - 2e-21 76.3 0.0 4.6e-21 75.1 0.0 1.6 2 0 0 2 2 2 1 F5/8 type C domain TMEM154 PF15102.4 NM_001014796.1_1 - 2.4 7.9 4.5 1.1 9.0 0.1 2.1 2 0 0 2 2 2 0 TMEM154 protein family Cadherin PF00028.15 NM_001318374.1_3 - 1.5e-101 333.0 11.4 2.3e-20 72.7 0.1 7.3 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.9 NM_001318374.1_3 - 5.8e-83 278.0 1.0 9.7e-83 277.3 1.0 1.4 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.10 NM_001318374.1_3 - 3.4e-19 68.3 0.0 2.2e-08 33.6 0.0 5.9 6 0 0 6 6 6 4 Cadherin-like Cadherin_3 PF16184.3 NM_001318374.1_3 - 5.4e-07 29.5 17.5 0.69 9.8 0.1 6.0 6 0 0 6 6 6 4 Cadherin-like EphA2_TM PF14575.4 NM_001318374.1_3 - 0.0073 17.0 0.3 0.019 15.6 0.3 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain He_PIG PF05345.10 NM_001318374.1_3 - 0.013 15.6 8.9 1.3 9.2 0.0 5.2 5 0 0 5 5 5 0 Putative Ig domain DUF1510 PF07423.9 NM_001318374.1_3 - 0.029 13.7 0.2 0.054 12.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) AP3D1 PF06375.9 NM_001318374.1_3 - 0.033 14.3 0.4 0.089 12.9 0.4 1.7 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4834 PF16118.3 NM_001318374.1_3 - 0.7 10.8 3.0 0.3 12.0 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Laminin_II PF06009.10 NM_015325.2_1 - 0.002 18.0 3.4 0.002 18.0 3.4 3.2 2 1 1 3 3 3 1 Laminin Domain II V_ATPase_I PF01496.17 NM_015325.2_1 - 9.8 3.8 14.3 23 2.5 14.3 1.6 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Shisa PF13908.4 NM_001272083.1_2 - 4.7e-27 95.3 0.9 4.7e-27 95.3 0.9 2.2 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator zf-H2C2_2 PF13465.4 NM_153380.3_2 - 1.2e-112 363.6 129.5 5.8e-09 35.9 0.3 20.1 20 0 0 20 20 19 18 Zinc-finger double domain zf-C2H2 PF00096.24 NM_153380.3_2 - 1e-95 309.0 119.3 2.7e-06 27.4 0.3 18.4 17 0 0 17 17 17 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_153380.3_2 - 1.3e-45 149.9 111.8 0.0066 17.1 0.3 18.4 17 0 0 17 17 17 17 C2H2-type zinc finger KRAB PF01352.25 NM_153380.3_2 - 4.3e-23 80.6 0.3 8.5e-23 79.6 0.3 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_153380.3_2 - 3.3e-19 68.6 75.2 0.0006 19.7 1.5 10.8 8 3 2 11 11 11 8 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_153380.3_2 - 2.8e-14 52.5 95.9 0.0013 18.5 0.6 17.2 17 0 0 17 17 17 8 C2H2-type zinc finger ADK_lid PF05191.12 NM_153380.3_2 - 5e-07 29.5 40.3 0.0027 17.6 0.3 8.8 7 2 0 7 7 7 5 Adenylate kinase, active site lid DZR PF12773.5 NM_153380.3_2 - 0.00031 20.6 71.4 1.6e+04 -53.0 71.4 9.0 1 1 0 1 1 0 0 Double zinc ribbon DUF3268 PF11672.6 NM_153380.3_2 - 0.00034 20.8 57.8 0.17 12.1 0.9 8.9 3 1 8 13 13 13 8 zinc-finger-containing domain C1_4 PF07975.10 NM_153380.3_2 - 0.0075 16.4 79.4 0.41 10.8 1.2 11.7 6 3 5 12 12 12 7 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 NM_153380.3_2 - 0.0093 16.6 74.3 0.57 10.8 1.5 9.7 2 1 5 9 9 9 4 zinc-ribbon family zf-trcl PF13451.4 NM_153380.3_2 - 0.049 13.4 72.3 2.7 7.8 0.2 14.7 14 3 0 14 14 14 0 Probable zinc-ribbon domain zf-C2H2_jaz PF12171.6 NM_153380.3_2 - 1.3 9.3 79.6 0.42 10.9 0.3 14.7 14 1 1 15 15 15 0 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_153380.3_2 - 2 8.4 66.6 7.1 6.6 0.0 15.5 17 0 0 17 17 17 0 XPA protein N-terminal BolA PF01722.16 NM_153380.3_2 - 4.6 7.5 25.3 5.6 7.2 0.4 6.5 5 1 0 5 5 5 0 BolA-like protein Prion PF00377.16 NM_001080121.1_2 - 1.1e-34 118.6 2.4 1.7e-34 118.0 2.4 1.3 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 NM_001080121.1_2 - 7.2e-17 60.8 4.0 1.6e-16 59.7 4.0 1.6 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal PRIMA1 PF16101.3 NM_001080121.1_2 - 2.7 7.9 6.4 6.8 6.6 6.4 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-H2C2_2 PF13465.4 NM_001318469.1_2 - 8e-62 203.0 54.3 4.7e-10 39.3 1.0 10.4 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001318469.1_2 - 1.7e-50 166.6 51.0 8.9e-07 28.9 0.3 9.3 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001318469.1_2 - 9.3e-25 85.0 56.2 0.0028 18.2 0.2 9.4 9 0 0 9 9 8 8 C2H2-type zinc finger KRAB PF01352.25 NM_001318469.1_2 - 8e-23 79.7 1.9 1.4e-22 78.9 1.9 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001318469.1_2 - 2.5e-20 71.8 38.7 0.0014 18.4 0.2 9.0 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001318469.1_2 - 6.5e-11 42.1 32.7 0.97 9.7 0.0 8.7 8 0 0 8 8 8 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001318469.1_2 - 1.4e-05 25.0 38.9 0.015 15.3 2.2 5.7 4 2 3 7 7 7 4 Zinc ribbon domain zf-met PF12874.5 NM_001318469.1_2 - 0.00023 21.3 50.0 0.01 16.1 2.0 8.9 9 0 0 9 9 9 4 Zinc-finger of C2H2 type Zn_Tnp_IS1595 PF12760.5 NM_001318469.1_2 - 0.0031 17.3 31.9 0.23 11.4 2.6 6.4 5 1 0 5 5 5 3 Transposase zinc-ribbon domain zf-Di19 PF05605.10 NM_001318469.1_2 - 0.015 15.5 2.5 0.015 15.5 2.5 4.4 3 1 2 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding DUF3268 PF11672.6 NM_001318469.1_2 - 0.044 14.0 17.5 0.55 10.4 0.2 4.4 3 1 0 4 4 4 0 zinc-finger-containing domain CpXC PF14353.4 NM_001318469.1_2 - 0.086 12.7 23.5 1.5 8.8 1.1 7.0 2 2 5 7 7 7 0 CpXC protein C1_4 PF07975.10 NM_001318469.1_2 - 0.27 11.4 34.9 0.39 10.9 2.9 6.1 2 1 5 8 8 7 0 TFIIH C1-like domain XPA_N PF01286.16 NM_001318469.1_2 - 0.76 9.7 32.5 8.1 6.4 0.3 8.0 8 0 0 8 8 8 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001318469.1_2 - 0.88 10.2 33.8 1.3 9.7 2.3 5.2 2 1 5 7 7 7 0 zinc-ribbon family zf-C2HE PF16278.3 NM_001318469.1_2 - 1.9 8.9 42.7 6.2 7.2 0.2 8.3 2 2 4 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-AN1 PF01428.14 NM_001318469.1_2 - 5.1 7.2 34.8 37 4.5 0.1 8.6 7 1 1 8 8 8 0 AN1-like Zinc finger 7tm_1 PF00001.19 NM_001164723.2_1 - 7.8e-40 136.7 20.5 1.1e-39 136.2 20.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SHNi-TPR PF10516.7 NM_001164723.2_1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 SHNi-TPR DUF2516 PF10724.7 NM_001164723.2_1 - 4.5 7.5 7.8 8.9 6.5 2.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2516) SPATIAL PF15256.4 NM_032149.2_3 - 2.9e-57 194.1 0.1 5.5e-57 193.2 0.1 1.5 1 0 0 1 1 1 1 SPATIAL zf-H2C2_2 PF13465.4 NM_003433.3_3 - 1.7e-122 394.7 131.9 6.1e-09 35.8 0.5 22.2 22 0 0 22 22 22 19 Zinc-finger double domain zf-C2H2 PF00096.24 NM_003433.3_3 - 1.6e-79 258.0 134.8 1.6e-06 28.1 1.3 19.0 18 0 0 18 18 18 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_003433.3_3 - 2.3e-50 164.7 141.2 0.00017 22.0 0.6 18.9 19 0 0 19 19 18 17 C2H2-type zinc finger KRAB PF01352.25 NM_003433.3_3 - 1.7e-22 78.6 1.1 3.1e-22 77.8 1.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_003433.3_3 - 8.3e-20 70.5 86.6 0.096 12.9 0.1 17.0 18 0 0 18 18 18 11 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_003433.3_3 - 4.8e-17 61.3 106.3 0.0029 17.4 0.3 17.1 17 0 0 17 17 17 12 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 NM_003433.3_3 - 9.1e-11 42.2 67.9 0.036 14.7 0.8 10.0 2 1 7 9 9 9 7 zinc-ribbon family Zn-ribbon_8 PF09723.8 NM_003433.3_3 - 6e-09 35.7 96.4 0.032 14.2 2.0 13.6 8 5 10 18 18 18 10 Zinc ribbon domain DZR PF12773.5 NM_003433.3_3 - 4.8e-08 32.8 74.6 0.19 11.6 0.3 10.1 2 1 2 4 4 3 1 Double zinc ribbon XPA_N PF01286.16 NM_003433.3_3 - 2.8e-06 27.1 75.1 2 8.4 0.0 16.7 17 0 0 17 17 16 3 XPA protein N-terminal C1_1 PF00130.20 NM_003433.3_3 - 7.6e-06 25.6 77.9 0.18 11.6 0.3 12.3 7 4 2 11 11 11 5 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_11 PF16622.3 NM_003433.3_3 - 0.026 14.1 0.7 0.026 14.1 0.7 16.5 17 0 0 17 17 17 0 zinc-finger C2H2-type BolA PF01722.16 NM_003433.3_3 - 2.6 8.2 17.1 18 5.6 0.7 5.1 3 1 2 5 5 5 0 BolA-like protein AbLIM_anchor PF16182.3 NM_001322889.1_1 - 1.9e-122 409.6 34.4 3.5e-83 280.4 19.6 2.5 2 1 1 3 3 3 2 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 NM_001322889.1_1 - 3.7e-14 52.3 0.2 1e-13 51.0 0.2 1.8 1 0 0 1 1 1 1 Villin headpiece domain LIM PF00412.20 NM_001322889.1_1 - 0.0005 20.1 3.0 0.0005 20.1 3.0 2.2 2 1 0 2 2 2 1 LIM domain PAC4 PF16093.3 NM_001128591.1_3 - 8.8e-25 86.6 0.2 1.3e-24 86.1 0.2 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Carn_acyltransf PF00755.18 NM_020549.4_1 - 8.9e-196 651.8 0.0 1e-195 651.7 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase SCAN PF02023.15 NM_001284527.1_3 - 7.2e-44 147.4 5.1 2e-43 146.0 5.1 1.8 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 NM_001284527.1_3 - 2.6e-41 138.1 44.7 7.7e-09 35.5 0.2 7.5 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001284527.1_3 - 5.3e-32 108.3 50.8 6.1e-07 29.4 0.6 7.5 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001284527.1_3 - 3.7e-19 67.6 51.1 0.002 18.7 0.5 7.9 8 0 0 8 8 6 6 C2H2-type zinc finger Myb_DNA-bind_4 PF13837.4 NM_001284527.1_3 - 6.3e-16 58.4 0.0 1.3e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain zf-C2H2_jaz PF12171.6 NM_001284527.1_3 - 3.1e-14 52.7 20.7 0.031 14.5 0.1 6.9 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001284527.1_3 - 4.2e-06 26.4 38.4 0.0052 16.6 1.2 6.9 6 1 0 6 6 6 4 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001284527.1_3 - 1.8e-05 24.6 20.6 0.083 12.9 0.4 4.7 3 2 1 4 4 4 3 Zinc ribbon domain KRAB PF01352.25 NM_001284527.1_3 - 0.00022 20.7 0.0 0.00046 19.7 0.0 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_11 PF16622.3 NM_001284527.1_3 - 0.0031 17.1 29.0 0.56 9.9 0.5 6.3 6 0 0 6 6 6 2 zinc-finger C2H2-type BolA PF01722.16 NM_001284527.1_3 - 0.0045 17.1 6.2 1.4 9.2 0.6 3.0 3 0 0 3 3 3 2 BolA-like protein zf-C2HC_2 PF13913.4 NM_001284527.1_3 - 0.0081 15.9 19.2 0.11 12.4 0.3 5.4 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-met PF12874.5 NM_001284527.1_3 - 0.019 15.2 39.7 0.15 12.4 2.0 6.7 6 0 0 6 6 6 0 Zinc-finger of C2H2 type HTH_18 PF12833.5 NM_001284527.1_3 - 0.037 14.2 2.3 50 4.1 0.1 3.6 3 1 0 3 3 3 0 Helix-turn-helix domain XPA_N PF01286.16 NM_001284527.1_3 - 0.062 13.2 17.3 3.4 7.7 0.0 6.1 6 0 0 6 6 6 0 XPA protein N-terminal zf-LYAR PF08790.9 NM_001284527.1_3 - 0.42 10.4 15.4 2.7 7.8 0.2 5.4 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger Zf_RING PF16744.3 NM_001284527.1_3 - 1.2 9.2 8.0 20 5.2 0.1 4.2 1 1 2 4 4 4 0 KIAA1045 RING finger zinc_ribbon_15 PF17032.3 NM_001284527.1_3 - 3.3 8.4 28.3 1.1 9.9 1.2 4.2 1 1 3 4 4 3 0 zinc-ribbon family DUF3268 PF11672.6 NM_001284527.1_3 - 6 7.1 12.8 14 5.9 0.6 3.7 4 0 0 4 4 3 0 zinc-finger-containing domain ADK_lid PF05191.12 NM_001284527.1_3 - 8 6.5 15.6 1.2 9.1 1.4 4.2 2 1 0 2 2 2 0 Adenylate kinase, active site lid RabGAP-TBC PF00566.16 NM_018309.4_2 - 9.5e-20 71.0 1.6 1.5e-19 70.4 1.6 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.18 NM_018309.4_2 - 3.3e-07 30.7 0.0 7.7e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain FKBP_C PF00254.26 NM_012181.4_2 - 7.3e-15 54.9 0.0 1.2e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.26 NM_012181.4_2 - 2.9e-12 45.7 3.7 1.1e-05 24.9 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_012181.4_2 - 2.1e-11 42.9 2.8 1.6e-05 24.5 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_012181.4_2 - 1.2e-08 34.9 0.6 3.7e-05 24.1 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_012181.4_2 - 2e-08 34.0 1.5 0.00099 19.0 0.1 2.4 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.4 NM_012181.4_2 - 7.5e-07 29.6 1.5 6.3e-05 23.5 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.4 NM_012181.4_2 - 4.1e-06 26.7 0.1 1.2e-05 25.3 0.1 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_012181.4_2 - 6.2e-06 25.7 0.5 4.8e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 TPR repeat TPR_8 PF13181.4 NM_012181.4_2 - 2.1e-05 24.3 0.9 0.00021 21.1 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 NM_012181.4_2 - 0.00015 21.4 0.3 0.019 14.8 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_012181.4_2 - 0.00025 21.4 3.7 0.00034 20.9 0.4 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.4 NM_012181.4_2 - 0.0006 19.9 0.4 0.034 14.4 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.4 NM_012181.4_2 - 0.0012 18.9 1.8 0.0035 17.5 0.4 2.3 1 1 2 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_012181.4_2 - 0.0038 17.3 1.1 0.021 14.9 0.0 2.5 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 NM_012181.4_2 - 0.021 15.3 0.1 0.46 11.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.4 NM_012181.4_2 - 0.021 15.0 2.3 0.71 10.1 0.1 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_012181.4_2 - 0.034 13.9 2.3 0.93 9.3 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat SYS1 PF09801.7 NM_001197129.1_1 - 1.1e-51 174.7 3.8 1.7e-51 174.1 3.8 1.3 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network GCR PF02155.13 NM_001204260.1_1 - 6.6e-186 617.6 9.5 8.2e-186 617.3 9.5 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 NM_001204260.1_1 - 9.2e-30 103.6 6.4 1e-29 103.5 4.7 1.8 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_001204260.1_1 - 1.9e-27 95.4 13.0 1.9e-27 95.4 13.0 2.1 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Syntaphilin PF15290.4 NM_001099746.1_1 - 4.7e-139 463.2 0.8 9e-139 462.3 0.8 1.4 1 0 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp Fez1 PF06818.13 NM_001099746.1_1 - 0.0001 22.7 6.6 0.00016 22.1 6.6 1.2 1 0 0 1 1 1 1 Fez1 FAM76 PF16046.3 NM_001099746.1_1 - 0.00063 19.0 6.7 0.00067 19.0 5.5 1.6 1 1 1 2 2 2 2 FAM76 protein PKcGMP_CC PF16808.3 NM_001099746.1_1 - 0.0093 15.7 6.1 0.0093 15.7 6.1 3.1 3 1 0 3 3 3 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Exonuc_VII_L PF02601.13 NM_001099746.1_1 - 0.026 14.0 1.6 0.039 13.4 1.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FPP PF05911.9 NM_001099746.1_1 - 0.072 11.2 11.8 0.1 10.7 11.8 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil IncA PF04156.12 NM_001099746.1_1 - 0.13 11.9 8.4 0.24 11.0 8.4 1.3 1 0 0 1 1 1 0 IncA protein Atg14 PF10186.7 NM_001099746.1_1 - 0.15 11.0 6.5 0.29 10.0 6.5 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sec8_exocyst PF04048.12 NM_001099746.1_1 - 0.23 11.3 7.4 0.72 9.6 0.3 2.3 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain BST2 PF16716.3 NM_001099746.1_1 - 0.25 11.8 7.8 0.53 10.8 7.8 1.5 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 Sec2p PF06428.9 NM_001099746.1_1 - 0.27 11.1 12.9 0.1 12.4 2.5 2.5 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p HR1 PF02185.14 NM_001099746.1_1 - 0.37 10.8 9.8 0.62 10.1 1.4 2.5 2 0 0 2 2 2 0 Hr1 repeat DUF342 PF03961.11 NM_001099746.1_1 - 0.44 8.9 4.3 0.63 8.5 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Spc7 PF08317.9 NM_001099746.1_1 - 1.1 8.0 11.1 1.8 7.2 11.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Spc42p PF11544.6 NM_001099746.1_1 - 1.3 8.9 7.1 0.38 10.7 1.1 2.4 2 0 0 2 2 2 0 Spindle pole body component Spc42p DUF745 PF05335.11 NM_001099746.1_1 - 1.4 8.5 6.3 2.1 8.0 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) CC2-LZ PF16516.3 NM_001099746.1_1 - 2.2 8.5 11.5 2.2 8.5 2.9 2.2 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF16 PF01519.14 NM_001099746.1_1 - 2.3 8.6 9.1 31 5.0 9.1 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 HMMR_N PF15905.3 NM_001099746.1_1 - 2.9 7.2 17.2 0.011 15.1 8.2 1.4 2 0 0 2 2 1 0 Hyaluronan mediated motility receptor N-terminal TPR_MLP1_2 PF07926.10 NM_001099746.1_1 - 3.6 7.5 13.2 1.2 9.1 6.6 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CALCOCO1 PF07888.9 NM_001099746.1_1 - 4.8 5.5 19.2 0.038 12.4 11.1 1.5 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like GrpE PF01025.17 NM_001099746.1_1 - 5.4 6.5 9.1 8.9 5.8 9.1 1.2 1 0 0 1 1 1 0 GrpE DUF4195 PF13836.4 NM_001002843.2_1 - 3.1e-86 288.0 24.5 3.1e-86 288.0 24.5 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF4195) zf-Di19 PF05605.10 NM_001002843.2_1 - 0.0033 17.5 1.0 0.0033 17.5 1.0 5.9 5 2 2 7 7 7 2 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.4 NM_001002843.2_1 - 0.016 15.5 0.1 0.016 15.5 0.1 8.3 8 1 0 8 8 8 0 Zinc-finger double domain zf-C2HC_2 PF13913.4 NM_001002843.2_1 - 0.34 10.7 7.5 0.24 11.2 1.2 3.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_9 PF16293.3 NM_001002843.2_1 - 1.6 8.5 13.8 12 5.7 1.4 4.6 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) DZF PF07528.12 NM_015174.1_1 - 4.8e-63 213.0 0.0 6.3e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 DZF domain zf-met PF12874.5 NM_015174.1_1 - 1.7e-15 56.7 16.4 4.2e-06 26.8 0.9 3.6 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_015174.1_1 - 6.5e-10 38.9 12.9 0.0084 16.3 0.3 3.4 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 NM_015174.1_1 - 0.0066 16.6 8.5 5 7.4 0.3 3.5 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) Lectin_C PF00059.19 NM_001144909.1_2 - 1.6e-24 86.6 6.2 2.7e-24 85.9 6.2 1.4 1 0 0 1 1 1 1 Lectin C-type domain DUF2170 PF09938.7 NM_001144909.1_2 - 4.9e-06 26.1 0.5 0.47 10.0 0.1 4.5 1 1 4 5 5 5 1 Uncharacterized protein conserved in bacteria (DUF2170) DUF2730 PF10805.6 NM_001144909.1_2 - 2e-05 24.5 6.7 0.11 12.5 0.5 3.2 1 1 3 4 4 4 3 Protein of unknown function (DUF2730) Reo_sigmaC PF04582.10 NM_001144909.1_2 - 0.00025 20.4 1.0 0.059 12.6 0.4 2.2 1 1 2 3 3 3 2 Reovirus sigma C capsid protein Occludin_ELL PF07303.11 NM_001144909.1_2 - 0.004 17.7 9.6 0.23 12.1 2.8 3.4 1 1 4 5 5 5 3 Occludin homology domain DUF4763 PF15960.3 NM_001144909.1_2 - 0.022 14.0 16.2 1.7 7.8 2.6 4.0 1 1 1 3 3 3 0 Domain of unknown function (DUF4763) Vps5 PF09325.8 NM_001144909.1_2 - 0.04 13.3 7.9 0.23 10.8 3.9 2.3 1 1 1 2 2 2 0 Vps5 C terminal like CHASE5 PF17149.2 NM_001144909.1_2 - 0.043 13.6 0.8 38 4.1 0.0 4.0 1 1 4 5 5 5 0 Periplasmic sensor domain found in signal transduction proteins DUF2357 PF09823.7 NM_001144909.1_2 - 0.065 12.3 6.5 0.62 9.1 0.4 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF2357) NPV_P10 PF05531.10 NM_001144909.1_2 - 0.084 13.2 7.2 3.3 8.1 2.7 2.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein RP-C_C PF11800.6 NM_001144909.1_2 - 0.094 12.6 6.0 0.83 9.5 5.0 3.1 1 1 1 2 2 2 0 Replication protein C C-terminal region DUF2408 PF10303.7 NM_001144909.1_2 - 0.11 12.9 16.2 16 5.9 0.2 5.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) CREPT PF16566.3 NM_001144909.1_2 - 0.16 12.0 6.5 4.3 7.4 0.8 2.8 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour UL45 PF05473.10 NM_001144909.1_2 - 0.17 11.4 2.6 0.24 10.9 1.3 1.8 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like DUF617 PF04759.11 NM_001144909.1_2 - 0.17 11.8 0.0 8.1 6.3 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function, DUF617 YceG PF02618.14 NM_001144909.1_2 - 0.18 11.3 3.2 1.4 8.3 3.1 2.0 1 1 0 1 1 1 0 YceG-like family tRNA-synt_His PF13393.4 NM_001144909.1_2 - 0.18 10.9 6.8 1.1 8.3 1.0 2.1 1 1 1 2 2 2 0 Histidyl-tRNA synthetase DIMCO_N PF16844.3 NM_001144909.1_2 - 0.21 11.8 6.0 7.6 6.8 0.4 2.4 1 1 1 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal VPS28 PF03997.10 NM_001144909.1_2 - 0.22 11.1 3.5 2.2 7.8 0.4 2.3 1 1 1 2 2 2 0 VPS28 protein BLOC1_2 PF10046.7 NM_001144909.1_2 - 0.25 11.5 13.1 6 7.1 1.8 3.6 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2397 PF09660.8 NM_001144909.1_2 - 0.36 9.6 5.4 1.1 8.0 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2397) DUF4363 PF14276.4 NM_001144909.1_2 - 0.44 10.5 3.7 1.3 9.0 2.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4363) DUF3422 PF11902.6 NM_001144909.1_2 - 0.77 8.7 9.8 2.8 6.8 0.3 2.9 1 1 4 5 5 5 0 Protein of unknown function (DUF3422) Med10 PF09748.7 NM_001144909.1_2 - 0.78 9.6 9.0 5.7 6.8 0.8 3.1 1 1 2 3 3 3 0 Transcription factor subunit Med10 of Mediator complex DALR_1 PF05746.13 NM_001144909.1_2 - 1.1 9.4 6.9 5.2 7.1 0.4 2.6 1 1 2 3 3 3 0 DALR anticodon binding domain Com_YlbF PF06133.9 NM_001144909.1_2 - 1.1 9.7 14.2 0.68 10.4 5.6 2.3 1 1 1 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA NYD-SP28 PF14772.4 NM_001144909.1_2 - 1.3 9.0 13.8 5.7 6.9 2.5 3.6 1 1 3 4 4 4 0 Sperm tail DGCR6 PF07324.9 NM_001144909.1_2 - 1.3 8.5 12.7 1.2 8.6 0.9 3.1 1 1 2 3 3 3 0 DiGeorge syndrome critical region 6 (DGCR6) protein HBM PF16591.3 NM_001144909.1_2 - 2.2 7.5 10.7 10 5.3 10.7 2.0 1 1 0 1 1 1 0 Helical bimodular sensor domain 5_3_exonuc PF01367.18 NM_001144909.1_2 - 3.5 8.2 7.0 26 5.4 0.8 2.6 1 1 1 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold XTBD PF11952.6 NM_017544.3_2 - 9.2e-23 79.7 0.0 2.1e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 XRN-Two Binding Domain, XTBD G-patch PF01585.21 NM_017544.3_2 - 6.8e-14 51.4 3.5 1.4e-13 50.3 3.5 1.6 1 0 0 1 1 1 1 G-patch domain R3H PF01424.20 NM_017544.3_2 - 1.5e-12 47.2 0.5 6.9e-12 45.1 0.2 2.2 2 0 0 2 2 2 1 R3H domain G-patch_2 PF12656.5 NM_017544.3_2 - 5.6e-06 26.2 0.8 1.2e-05 25.1 0.8 1.6 1 0 0 1 1 1 1 G-patch domain dsrm PF00035.24 NM_017544.3_2 - 0.00012 22.5 4.8 0.017 15.7 0.0 3.2 4 0 0 4 4 4 2 Double-stranded RNA binding motif S8_pro-domain PF16470.3 NM_017544.3_2 - 0.12 13.0 0.7 1.1 10.0 0.4 2.4 2 0 0 2 2 2 0 Peptidase S8 pro-domain 7tm_4 PF13853.4 NM_001004751.2_2 - 1.3e-105 353.0 22.6 1.6e-105 352.7 22.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004751.2_2 - 1.6e-16 60.3 21.7 6.9e-16 58.1 21.7 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001004751.2_2 - 6.3e-06 25.6 10.9 6.3e-06 25.6 10.9 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Cornifin PF02389.13 NM_005987.3_1 - 8.1e-29 100.4 53.7 4.6e-23 81.8 35.6 3.2 2 1 1 3 3 3 2 Cornifin (SPRR) family RNA_pol_Rpb1_R PF05001.11 NM_005987.3_2 - 2.7 8.4 15.9 9.4 6.7 0.4 3.7 3 1 0 3 3 3 0 RNA polymerase Rpb1 C-terminal repeat C2-set_2 PF08205.10 NM_015480.2_2 - 6.1e-18 64.6 0.1 7.4e-17 61.1 0.0 2.4 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 NM_015480.2_2 - 7.9e-15 55.1 0.5 5.8e-06 26.7 0.1 3.5 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 NM_015480.2_2 - 5.9e-13 48.8 0.2 5.3e-11 42.5 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 NM_015480.2_2 - 6.9e-11 42.0 0.4 0.0017 18.4 0.2 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_015480.2_2 - 3.2e-10 39.8 0.1 2.3e-06 27.4 0.1 3.1 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_015480.2_2 - 9.9e-07 28.9 0.7 0.09 13.0 0.2 3.0 3 1 0 3 3 3 2 Immunoglobulin domain Adeno_E3_CR2 PF02439.13 NM_015480.2_2 - 0.16 11.7 0.9 0.61 9.8 0.9 2.0 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 VCX_VCY PF15231.4 NM_015480.2_3 - 0.36 11.3 1.6 0.58 10.7 1.6 1.2 1 0 0 1 1 1 0 Variable charge X/Y family TMEM191C PF15194.4 NM_001242313.1_3 - 2.8e-49 166.1 4.3 1.3e-48 163.9 4.4 2.1 2 0 0 2 2 2 1 TMEM191C family TMCO5 PF14992.4 NM_001242313.1_3 - 1 8.7 26.6 0.19 11.2 0.4 2.3 2 1 0 2 2 2 0 TMCO5 family GAS PF13851.4 NM_001242313.1_3 - 1.8 7.7 26.3 3.4 6.9 26.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding BLOC1_2 PF10046.7 NM_001242313.1_3 - 5.3 7.3 11.4 0.73 10.1 0.9 2.6 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-H PF05837.10 NM_001242313.1_3 - 5.7 7.3 26.0 9.4 6.6 10.6 2.7 1 1 2 3 3 3 0 Centromere protein H (CENP-H) CorA PF01544.16 NM_001242313.1_3 - 9.4 5.3 11.2 8.5 5.5 3.0 2.3 1 1 0 2 2 2 0 CorA-like Mg2+ transporter protein INCA1 PF15142.4 NM_001167986.1_1 - 1e-103 344.8 3.8 1e-103 344.8 3.8 2.2 2 0 0 2 2 2 1 INCA1 DAP10 PF07213.9 NM_001173515.1_1 - 0.008 16.0 2.4 0.013 15.3 2.4 1.3 1 0 0 1 1 1 1 DAP10 membrane protein IncA PF04156.12 NM_001173515.1_1 - 0.047 13.3 0.0 0.06 13.0 0.0 1.1 1 0 0 1 1 1 0 IncA protein FAST_1 PF06743.13 NM_001136194.1_3 - 6.9e-21 73.8 2.0 6.9e-21 73.8 2.0 2.0 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 1 RAP PF08373.8 NM_001136194.1_3 - 2e-11 43.7 0.0 4.4e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 RAP domain FAST_2 PF08368.10 NM_001136194.1_3 - 3.2e-08 34.2 0.3 8.9e-08 32.7 0.1 2.0 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 2 DDOST_48kD PF03345.12 NM_005216.4_3 - 1.7e-152 507.9 0.0 2e-152 507.7 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta CN_hydrolase PF00795.20 NM_018161.4_1 - 3.1e-47 161.0 0.0 4.2e-47 160.5 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.15 NM_018161.4_1 - 1.3e-27 96.3 0.0 5.3e-27 94.4 0.0 1.9 1 1 0 1 1 1 1 NAD synthase RRM_1 PF00076.20 NM_203390.2_2 - 4.4e-26 90.3 4.3 7.2e-06 25.6 0.2 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 NM_001100391.1_3 - 6.3e-11 41.8 0.0 1e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XhlA PF10779.7 NM_001100391.1_3 - 0.067 13.3 6.0 0.11 12.5 6.0 1.4 1 0 0 1 1 1 0 Haemolysin XhlA ORF11CD3 PF10549.7 NM_001100391.1_3 - 0.99 9.4 4.6 3.3 7.8 1.8 2.3 2 0 0 2 2 2 0 ORF11CD3 domain HLH PF00010.24 NM_001012415.2_2 - 2.3e-05 24.1 1.5 4.1e-05 23.3 0.4 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain pKID PF02173.15 NM_004379.4_3 - 2.5e-20 71.5 2.5 4.4e-20 70.7 2.5 1.4 1 0 0 1 1 1 1 pKID domain bZIP_1 PF00170.19 NM_004379.4_3 - 7.1e-18 64.3 12.6 1.6e-17 63.2 12.6 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_004379.4_3 - 2.8e-06 27.2 13.4 5.7e-06 26.2 13.4 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_004379.4_3 - 0.1 13.0 5.7 0.19 12.2 5.7 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor Lectin_C PF00059.19 NM_001144895.1_2 - 1.8e-21 76.7 4.5 3.2e-21 76.0 4.5 1.4 1 0 0 1 1 1 1 Lectin C-type domain DUF2170 PF09938.7 NM_001144895.1_2 - 0.003 17.1 0.2 1.1 8.8 0.1 2.9 1 1 2 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2170) Occludin_ELL PF07303.11 NM_001144895.1_2 - 0.025 15.1 2.9 0.63 10.6 0.3 2.2 1 1 1 2 2 2 0 Occludin homology domain DUF2730 PF10805.6 NM_001144895.1_2 - 0.039 13.9 0.9 5.7 7.0 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Vps5 PF09325.8 NM_001144895.1_2 - 0.18 11.2 2.2 0.27 10.6 2.2 1.1 1 0 0 1 1 1 0 Vps5 C terminal like DUF4763 PF15960.3 NM_001144895.1_2 - 1.5 8.0 7.3 21 4.2 0.6 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) DUF2408 PF10303.7 NM_001144895.1_2 - 2.1 8.8 6.6 83 3.6 2.6 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Reo_sigmaC PF04582.10 NM_001144895.1_2 - 4.3 6.5 9.2 0.29 10.4 0.1 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF1539 PF07560.9 NM_001282492.1_1 - 0.074 13.0 0.2 3.5 7.6 0.0 2.6 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1539) IFRD PF05004.11 NM_001282492.1_1 - 0.18 10.8 0.1 0.25 10.3 0.1 1.2 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) FYVE_2 PF02318.14 NM_001190411.1_3 - 2.3e-37 127.7 2.2 3.7e-37 127.0 2.2 1.3 1 0 0 1 1 1 1 FYVE-type zinc finger zf-piccolo PF05715.11 NM_001190411.1_3 - 0.00011 22.2 7.3 0.00011 22.2 7.3 2.1 2 0 0 2 2 2 1 Piccolo Zn-finger zf-B_box PF00643.22 NM_001190411.1_3 - 0.29 11.2 4.8 0.18 11.9 1.6 2.2 2 0 0 2 2 2 0 B-box zinc finger 7tm_4 PF13853.4 NM_001005195.1_1 - 2.1e-47 162.0 20.3 2.8e-47 161.7 20.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005195.1_1 - 4.3e-20 71.9 23.7 7e-20 71.2 23.7 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PTS_EIIB PF00367.18 NM_001005195.1_1 - 0.084 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 phosphotransferase system, EIIB RIIa PF02197.15 NM_138644.2_1 - 2.2e-15 55.9 0.0 4.8e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Longin PF13774.4 NM_001201584.1_1 - 7.5e-11 41.8 0.0 1.3e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Epimerase_2 PF02350.17 NM_001190388.1_3 - 1.3e-63 214.8 0.0 1.9e-63 214.3 0.0 1.2 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase ROK PF00480.18 NM_001190388.1_3 - 8.4e-54 182.9 1.4 1.2e-53 182.4 1.4 1.2 1 0 0 1 1 1 1 ROK family FGGY_N PF00370.19 NM_001190388.1_3 - 0.0024 17.3 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain DRTGG PF07085.10 NM_001190388.1_3 - 0.0063 16.1 0.2 0.015 14.9 0.2 1.6 1 0 0 1 1 1 1 DRTGG domain Hexokinase_1 PF00349.19 NM_001190388.1_3 - 0.019 14.9 0.0 0.032 14.1 0.0 1.2 1 0 0 1 1 1 0 Hexokinase Ribosomal_L9_N PF01281.17 NM_001300733.1_3 - 3.2e-16 58.5 0.1 5.6e-16 57.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Acatn PF13000.5 NM_004733.3_1 - 1.8e-121 406.2 16.3 1.6e-73 248.0 7.3 3.0 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 Pox_MCEL PF03291.14 NM_003799.2_2 - 1.2e-120 402.5 7.2 1.5e-120 402.1 7.2 1.1 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.4 NM_003799.2_2 - 2.2e-10 41.0 0.0 3.8e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_003799.2_2 - 1.5e-08 34.5 0.1 2.5e-08 33.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_003799.2_2 - 2.1e-07 31.3 0.0 4e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 NM_003799.2_2 - 8.9e-07 28.8 0.0 1.6e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_003799.2_2 - 6e-05 23.6 0.0 0.0001 22.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.4 NM_003799.2_2 - 0.026 14.4 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain SH3BGR PF04908.13 NM_003799.2_2 - 0.082 12.9 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein Band_7_C PF16200.3 NM_001287031.1_3 - 2.4e-25 88.2 0.7 5.8e-25 87.0 0.7 1.7 1 0 0 1 1 1 1 C-terminal region of band_7 Band_7 PF01145.23 NM_001287031.1_3 - 3.8e-15 56.2 3.2 8e-15 55.2 3.1 1.7 1 1 0 1 1 1 1 SPFH domain / Band 7 family FlgN PF05130.10 NM_001287031.1_3 - 0.022 15.1 3.3 0.037 14.4 3.3 1.2 1 0 0 1 1 1 0 FlgN protein MFS_1 PF07690.14 NM_003053.3_1 - 8.1e-40 136.7 47.9 3.7e-31 108.2 40.7 3.1 1 1 2 3 3 3 2 Major Facilitator Superfamily CPP1-like PF11833.6 NM_003053.3_1 - 0.81 9.1 4.4 1.9 7.9 4.4 1.6 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF2070 PF09843.7 NM_003053.3_1 - 5.2 5.1 8.4 0.22 9.6 2.5 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) zf-CCCH_2 PF14608.4 NM_003053.3_3 - 0.015 15.6 5.0 0.015 15.6 5.0 3.1 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger 7tm_1 PF00001.19 NM_001708.2_1 - 1.5e-43 148.9 13.1 1.8e-43 148.6 13.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 NM_001708.2_1 - 9e-07 28.4 12.2 9e-07 28.4 12.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 NM_001708.2_1 - 3e-05 23.8 9.2 0.00017 21.3 2.0 2.1 2 0 0 2 2 2 2 Olfactory receptor WBP-1 PF11669.6 NM_001708.2_1 - 0.55 10.8 5.4 0.12 12.9 0.8 2.0 2 0 0 2 2 2 0 WW domain-binding protein 1 SNCAIP_SNCA_bd PF16700.3 NM_001308107.1_3 - 2e-24 84.9 7.3 4.6e-24 83.8 7.3 1.6 1 0 0 1 1 1 1 Synphilin-1 alpha-Synuclein-binding domain Ank_2 PF12796.5 NM_001308107.1_3 - 1.8e-09 37.9 0.0 4.4e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001308107.1_3 - 8.8e-08 32.4 0.0 0.00021 21.7 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001308107.1_3 - 0.00012 22.2 0.0 0.0011 19.1 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 NM_001308107.1_3 - 0.0025 18.1 0.1 0.0069 16.7 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeat Lzipper-MIP1 PF14389.4 NM_001308107.1_3 - 2.3 8.4 7.6 0.51 10.5 1.7 2.6 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 DSPc PF00782.18 NM_020185.4_1 - 1.3e-32 112.3 0.0 1.6e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 NM_020185.4_1 - 0.0011 18.5 0.6 0.0018 17.7 0.1 1.5 1 1 1 2 2 2 1 Protein-tyrosine phosphatase Arfaptin PF06456.11 NM_014447.3_3 - 1e-81 273.7 9.8 1.4e-81 273.3 9.8 1.1 1 0 0 1 1 1 1 Arfaptin-like domain TPR_MLP1_2 PF07926.10 NM_014447.3_3 - 0.91 9.5 4.5 14 5.7 0.2 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein SapB_1 PF05184.13 NM_002778.3_2 - 1.9e-46 155.5 22.9 9.3e-14 51.0 0.8 4.8 4 0 0 4 4 4 4 Saposin-like type B, region 1 SapB_2 PF03489.15 NM_002778.3_2 - 1.3e-41 140.2 26.5 3.3e-11 43.0 0.9 5.4 5 0 0 5 5 5 4 Saposin-like type B, region 2 SapA PF02199.13 NM_002778.3_2 - 2.1e-30 104.4 30.3 1.9e-16 59.8 10.0 3.9 5 0 0 5 5 5 2 Saposin A-type domain TLE_N PF03920.13 NM_002778.3_2 - 0.1 12.6 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain Helicase_C_3 PF13625.4 NM_002778.3_2 - 0.17 11.9 0.0 0.59 10.2 0.0 1.8 2 0 0 2 2 2 0 Helicase conserved C-terminal domain zf-DBF PF07535.10 NM_002778.3_2 - 1 9.4 4.8 22 5.1 0.1 3.3 3 0 0 3 3 3 0 DBF zinc finger DUF3456 PF11938.6 NM_002778.3_2 - 1.1 9.6 17.4 3.5 8.0 0.8 5.6 3 3 3 6 6 6 0 TLR4 regulator and MIR-interacting MSAP DUF1284 PF06935.9 NM_002778.3_2 - 4.8 7.5 12.3 1.2 9.5 0.4 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1284) DUF3585 PF12130.6 NM_032867.2_1 - 3.1e-41 140.6 31.9 3.1e-41 140.6 31.9 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3585) Het-C PF07217.9 NM_032867.2_1 - 8.6 4.6 7.5 13 4.1 7.5 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Ufd2P_core PF10408.7 NM_004788.3_1 - 1.9e-153 512.2 8.6 2.8e-153 511.7 8.6 1.2 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.13 NM_004788.3_1 - 4.8e-32 109.8 0.4 1.2e-31 108.5 0.4 1.7 1 0 0 1 1 1 1 U-box domain PI-PLC-X PF00388.17 NM_016341.3_2 - 3.5e-59 198.4 0.0 1e-58 196.9 0.0 1.9 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 NM_016341.3_2 - 1.6e-34 118.6 0.0 2.5e-32 111.5 0.0 3.2 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain RasGEF PF00617.17 NM_016341.3_2 - 1.2e-21 77.5 0.1 3.2e-21 76.1 0.1 1.7 1 0 0 1 1 1 1 RasGEF domain RA PF00788.21 NM_016341.3_2 - 9.4e-21 74.1 0.7 5.8e-19 68.4 0.4 2.6 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain C2 PF00168.28 NM_016341.3_2 - 3.4e-08 33.6 0.0 8.9e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.9 NM_016341.3_2 - 4.7e-05 23.7 0.0 0.00022 21.5 0.0 2.2 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like YIF1 PF03878.13 NM_020470.2_3 - 3.4e-83 278.7 1.3 4.1e-83 278.4 1.3 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.15 NM_020470.2_3 - 1.1e-11 44.7 7.6 2.3e-11 43.6 7.6 1.5 1 0 0 1 1 1 1 Yip1 domain KIAA1430 PF13879.4 NM_020827.2_1 - 4.6e-16 59.3 3.0 4.6e-16 59.3 3.0 2.3 2 0 0 2 2 2 1 KIAA1430 homologue zf-DHHC PF01529.18 NM_001001483.2_2 - 6e-30 103.9 18.9 6e-30 103.9 18.9 3.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_4 PF13637.4 NM_001001483.2_2 - 7.9e-30 102.7 0.1 7.2e-10 39.1 0.0 4.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001001483.2_2 - 6e-29 99.5 0.2 5.2e-09 36.1 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_001001483.2_2 - 1.4e-28 99.1 0.2 6.4e-13 49.0 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_001001483.2_2 - 1.4e-25 86.4 1.4 1.1e-05 25.3 0.0 7.6 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.28 NM_001001483.2_2 - 2.3e-20 71.9 2.8 8.1e-05 22.8 0.1 6.6 6 0 0 6 6 6 5 Ankyrin repeat MIF4G PF02854.17 NM_014772.2_1 - 3.4e-27 95.4 5.4 4.8e-27 94.9 5.4 1.1 1 0 0 1 1 1 1 MIF4G domain bZIP_Maf PF03131.15 NM_001261461.1_1 - 7.7e-17 61.5 5.0 1.5e-16 60.5 5.0 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.19 NM_001261461.1_1 - 1.1e-07 31.7 10.0 2.1e-07 30.8 10.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001261461.1_1 - 0.00074 19.4 12.0 0.0017 18.3 12.0 1.5 1 0 0 1 1 1 1 Basic region leucine zipper Peptidase_Mx PF15887.3 NM_001261461.1_1 - 0.033 13.5 0.1 0.064 12.5 0.1 1.4 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase HCO3_cotransp PF00955.19 NM_001321103.1_1 - 1.3e-244 812.7 7.4 1.7e-244 812.3 7.4 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 NM_001321103.1_1 - 3.3e-105 351.6 0.0 9.6e-105 350.1 0.0 1.8 1 1 0 1 1 1 1 Band 3 cytoplasmic domain CD24 PF14984.4 NM_198216.1_1 - 0.083 13.0 0.4 0.15 12.1 0.4 1.4 1 0 0 1 1 1 0 CD24 protein LSM PF01423.20 NM_198216.1_2 - 6.9e-20 70.4 0.1 9.7e-20 69.9 0.1 1.2 1 0 0 1 1 1 1 LSM domain P2X_receptor PF00864.17 NM_170683.3_2 - 6.2e-139 463.0 0.0 2.4e-133 444.6 0.0 2.0 2 0 0 2 2 2 2 ATP P2X receptor zf-H2C2_2 PF13465.4 NM_001317012.1_3 - 1.1e-46 155.1 79.4 3.5e-08 33.4 1.1 11.9 12 0 0 12 12 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001317012.1_3 - 1.9e-32 109.8 85.7 0.00021 21.4 0.2 11.0 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001317012.1_3 - 4.8e-25 85.9 91.0 0.00071 20.1 1.1 11.4 11 0 0 11 11 10 10 C2H2-type zinc finger BTB PF00651.29 NM_001317012.1_3 - 1.4e-22 79.9 2.1 2.6e-22 79.0 2.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_11 PF16622.3 NM_001317012.1_3 - 1.4e-07 31.0 51.7 0.035 13.7 0.2 9.6 9 0 0 9 9 9 4 zinc-finger C2H2-type zf-met PF12874.5 NM_001317012.1_3 - 2.1e-07 31.0 64.2 0.092 13.0 0.4 10.3 10 0 0 10 10 10 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 NM_001317012.1_3 - 1.7e-06 27.7 75.6 0.00082 19.1 0.9 10.7 11 0 0 11 11 11 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001317012.1_3 - 0.00064 19.8 44.2 0.95 9.7 0.4 9.7 10 0 0 10 10 10 3 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.3 NM_001317012.1_3 - 0.007 16.5 4.7 0.007 16.5 4.7 5.4 1 1 2 4 4 4 1 C2H2-type zinc ribbon BolA PF01722.16 NM_001317012.1_3 - 0.014 15.5 17.4 0.049 13.8 1.3 5.3 3 1 2 5 5 5 0 BolA-like protein HypA PF01155.17 NM_001317012.1_3 - 0.38 10.6 32.5 0.66 9.9 2.5 5.2 1 1 1 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.12 NM_001317012.1_3 - 1 9.3 21.9 1.5 8.8 0.3 6.0 4 2 1 5 5 5 0 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 NM_001317012.1_3 - 2.7 8.7 32.8 18 6.0 2.9 5.7 3 1 2 5 5 5 0 zinc-ribbon family Zn-ribbon_8 PF09723.8 NM_001317012.1_3 - 7.1 6.7 44.7 0.66 10.0 1.9 7.3 4 3 4 8 8 8 0 Zinc ribbon domain Focadhesin PF11229.6 NM_017794.4_2 - 0 1010.3 7.4 0 1009.6 7.4 1.3 1 0 0 1 1 1 1 Focadhesin DUF3730 PF12530.6 NM_017794.4_2 - 1.2e-69 234.3 0.6 1.2e-69 234.3 0.6 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF3730) HEAT PF02985.20 NM_017794.4_2 - 0.032 14.3 7.3 0.21 11.8 0.5 5.0 4 0 0 4 4 4 0 HEAT repeat V-set PF07686.15 NM_001207063.1_3 - 3.1e-18 65.8 0.0 6.1e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001207063.1_3 - 6.8e-06 26.5 0.1 0.0015 19.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001207063.1_3 - 3.1e-05 23.9 0.0 0.0046 17.0 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 NM_001207063.1_3 - 3.6e-05 23.6 0.0 6.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain 4F5 PF04419.12 NM_001267709.1_1 - 6.3e-09 36.4 17.3 9.4e-09 35.9 17.3 1.3 1 0 0 1 1 1 1 4F5 protein family zf-met PF12874.5 NM_001267709.1_1 - 0.00068 19.8 0.4 0.0016 18.6 0.4 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001267709.1_1 - 0.078 13.2 1.5 0.13 12.5 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Neur_chan_memb PF02932.14 NM_001191321.2_2 - 2.9e-46 158.3 1.3 4.2e-45 154.5 1.3 2.1 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 NM_001191321.2_2 - 8.8e-37 126.5 0.0 1.4e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain OAD_gamma PF04277.11 NM_001191321.2_2 - 0.13 12.7 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain C2 PF00168.28 NM_025151.4_3 - 6.1e-18 64.9 0.0 1.1e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain RBD-FIP PF09457.8 NM_025151.4_3 - 1.2e-16 60.2 2.7 2.2e-16 59.4 2.7 1.5 1 0 0 1 1 1 1 FIP domain DUF3715 PF12509.6 NM_001321785.1_3 - 1e-80 268.9 13.0 3.2e-39 134.1 2.3 5.0 4 1 1 5 5 5 4 Protein of unknown function (DUF3715) DUF3699 PF12480.6 NM_001321785.1_3 - 7.7e-29 99.5 0.2 3.5e-24 84.6 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF3699) DUF3480 PF11979.6 NM_004799.3_3 - 5.4e-175 581.4 0.0 7.4e-175 581.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3480) SARA PF11409.6 NM_004799.3_3 - 6.7e-19 67.7 10.6 6.7e-19 67.7 10.6 2.9 3 0 0 3 3 3 1 Smad anchor for receptor activation (SARA) FYVE PF01363.19 NM_004799.3_3 - 6.7e-18 64.5 16.1 6.7e-18 64.5 16.1 2.8 3 0 0 3 3 3 1 FYVE zinc finger LRAT PF04970.11 NM_001146729.1_1 - 3e-35 121.2 0.0 4.3e-35 120.6 0.0 1.2 1 0 0 1 1 1 1 Lecithin retinol acyltransferase SRF-TF PF00319.16 NM_001130926.2_2 - 2e-23 81.5 0.4 4.3e-23 80.4 0.4 1.6 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 NM_001130926.2_2 - 2e-05 24.3 0.0 2e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 Holliday junction regulator protein family C-terminal repeat TFIIA PF03153.11 NM_001130926.2_2 - 0.8 9.5 11.5 1.2 9.0 11.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_S18 PF01084.18 NM_001297770.1_2 - 7.7e-07 29.1 0.8 2.2e-06 27.6 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein S18 CTD_bind PF04818.11 NM_001145444.1_1 - 4.9e-17 62.4 0.0 1.3e-16 61.0 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.20 NM_001145444.1_1 - 1.9e-09 37.0 0.0 3.9e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_001145444.1_1 - 0.012 15.3 0.0 0.032 14.0 0.0 1.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif Secretin_N_2 PF07655.11 NM_001145444.1_2 - 0.53 10.7 10.5 0.91 10.0 10.5 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Apt1 PF10351.7 NM_001145444.1_2 - 0.53 8.9 3.7 0.78 8.4 3.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RUN PF02759.17 NM_001098509.1_2 - 1.2e-34 119.0 0.0 2.4e-34 118.1 0.0 1.5 1 0 0 1 1 1 1 RUN domain RabGAP-TBC PF00566.16 NM_001098509.1_2 - 2.2e-31 109.1 6.0 5.6e-30 104.5 3.8 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain zf-BED PF02892.13 NM_001098509.1_2 - 0.013 15.4 0.0 0.048 13.6 0.0 2.0 1 0 0 1 1 1 0 BED zinc finger DUF3548 PF12068.6 NM_001098509.1_2 - 0.015 14.7 0.0 0.74 9.2 0.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF3548) Cullin_binding PF03556.13 NM_001098509.1_2 - 0.33 11.4 1.9 2.4 8.6 1.7 2.1 2 0 0 2 2 2 0 Cullin binding KH_1 PF00013.27 NM_016626.4_2 - 1.4e-25 88.8 1.6 1.6e-13 50.1 0.1 2.3 2 0 0 2 2 2 2 KH domain zf-C3HC4_3 PF13920.4 NM_016626.4_2 - 7.3e-11 41.6 11.9 1.2e-10 41.0 11.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_016626.4_2 - 3.4e-06 26.7 11.0 6.1e-06 25.9 11.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.23 NM_016626.4_2 - 8.1e-05 22.3 13.1 0.00016 21.4 13.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) KH_2 PF07650.15 NM_016626.4_2 - 0.013 15.2 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 KH domain KH_4 PF13083.4 NM_016626.4_2 - 0.064 13.0 0.0 5.8 6.7 0.0 2.3 2 0 0 2 2 2 0 KH domain zf-RING_5 PF14634.4 NM_016626.4_2 - 0.21 11.5 11.4 0.44 10.4 11.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_4 PF14570.4 NM_016626.4_2 - 7.6 6.2 8.9 16 5.2 8.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Sas10_Utp3 PF04000.13 NM_001190263.1_1 - 7.1e-17 61.6 0.1 1.2e-16 60.9 0.1 1.3 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Pkinase PF00069.23 NM_001004057.1_3 - 1.3e-64 217.9 0.0 1.7e-64 217.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001004057.1_3 - 4.1e-35 121.2 0.0 5.4e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 NM_001004057.1_3 - 1.8e-20 73.3 0.4 3.5e-20 72.3 0.0 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain Kinase-like PF14531.4 NM_001004057.1_3 - 3.1e-06 26.6 0.0 5e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like ATP-synt_DE_N PF02823.14 NM_001687.4_3 - 2e-15 56.3 0.1 2.7e-15 55.9 0.1 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain UPF0020 PF01170.16 NM_001321477.1_2 - 6e-26 91.2 0.0 1.2e-25 90.2 0.0 1.4 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.4 NM_001321477.1_2 - 1.3e-09 38.6 0.0 2.2e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001321477.1_2 - 1.7e-09 37.6 0.0 2.6e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001321477.1_2 - 4.9e-08 33.4 0.0 8.7e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 NM_001321477.1_2 - 2.5e-06 26.9 0.0 4.2e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 NM_001321477.1_2 - 3.8e-06 26.4 0.0 6.2e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.10 NM_001321477.1_2 - 0.0014 19.2 0.0 0.0025 18.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.18 NM_001321477.1_2 - 0.0015 17.8 0.0 0.0025 17.0 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase THUMP PF02926.15 NM_001321477.1_2 - 0.012 15.6 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 THUMP domain AviRa PF11599.6 NM_001321477.1_2 - 0.034 13.6 0.0 2.9 7.3 0.0 2.2 1 1 1 2 2 2 0 RRNA methyltransferase AviRa GAGE PF05831.9 NM_130777.2_1 - 1e-40 138.4 5.5 1.3e-40 138.1 5.5 1.1 1 0 0 1 1 1 1 GAGE protein MAGE PF01454.17 NM_138704.3_1 - 5.5e-28 98.0 0.0 5.5e-28 98.0 0.0 3.0 2 1 0 2 2 2 1 MAGE family 7tm_1 PF00001.19 NM_138704.3_3 - 0.089 11.9 2.4 0.12 11.4 2.4 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) ETRAMP PF09716.8 NM_138704.3_3 - 9 6.3 18.9 29 4.7 18.9 1.9 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Pkinase PF00069.23 NM_002757.3_3 - 1.3e-57 195.0 0.0 1.9e-57 194.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_002757.3_3 - 7.5e-36 123.6 0.0 1e-35 123.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 NM_002757.3_3 - 3.1e-12 46.1 0.0 5.4e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.4 NM_002757.3_3 - 0.0052 16.0 0.0 0.0088 15.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Rad51 PF08423.9 NM_001321817.1_3 - 1e-42 146.0 0.0 1.6e-42 145.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 NM_001321817.1_3 - 1e-07 31.6 0.0 1.5e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.13 NM_001321817.1_3 - 0.00012 21.3 0.7 0.00056 19.1 0.7 1.8 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_24 PF13479.4 NM_001321817.1_3 - 0.00091 18.9 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.11 NM_001321817.1_3 - 0.0088 15.3 0.2 0.021 14.0 0.2 1.5 1 1 0 1 1 1 1 KaiC ATPase_2 PF01637.16 NM_001321817.1_3 - 0.046 13.5 0.0 0.068 12.9 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RecA PF00154.19 NM_001321817.1_3 - 0.082 12.2 0.1 0.25 10.6 0.0 1.6 2 0 0 2 2 2 0 recA bacterial DNA recombination protein AAA PF00004.27 NM_001321817.1_3 - 0.11 12.8 0.2 0.24 11.7 0.2 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DnaJ_CXXCXGXG PF00684.17 NM_001256749.1_2 - 0.0049 17.1 33.9 0.59 10.4 6.1 3.4 1 1 2 3 3 3 2 DnaJ central domain Neur_chan_memb PF02932.14 NM_000747.2_3 - 2.7e-73 246.8 0.0 4.3e-73 246.2 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 NM_000747.2_3 - 8.4e-64 214.8 0.0 1.1e-63 214.5 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain RRM_1 PF00076.20 NM_019027.3_1 - 7.7e-37 124.8 0.1 5.6e-14 51.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_019027.3_1 - 2.2e-05 24.4 0.1 0.27 11.3 0.0 4.3 4 0 0 4 4 4 2 RNA recognition motif RRM_5 PF13893.4 NM_019027.3_1 - 0.00065 19.2 0.0 0.073 12.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Coilin_N PF15862.3 NM_019027.3_1 - 1.5 8.5 12.8 0.6 9.8 8.9 2.0 2 0 0 2 2 2 0 Coilin N-terminus OAD_gamma PF04277.11 NM_019027.3_3 - 4.6 7.8 4.4 8.8 6.9 4.4 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Trypan_PARP PF05887.9 NM_015537.4_2 - 5e-06 26.5 11.2 5e-06 26.5 11.2 1.8 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) DUF4347 PF14252.4 NM_015537.4_2 - 0.0011 18.7 0.0 0.0016 18.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) IQ PF00612.25 NM_015537.4_2 - 0.0045 16.5 4.4 0.29 10.9 0.1 3.2 3 0 0 3 3 3 2 IQ calmodulin-binding motif GIY-YIG PF01541.22 NM_178044.2_3 - 7.3e-09 35.7 0.0 2.1e-08 34.2 0.0 1.7 2 0 0 2 2 2 1 GIY-YIG catalytic domain FANCL_C PF11793.6 NM_178044.2_3 - 0.052 13.6 2.0 0.1 12.7 2.0 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain Ig_3 PF13927.4 NM_052931.4_2 - 8.2e-08 32.6 1.0 0.019 15.4 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_052931.4_2 - 5.6e-07 29.6 0.0 1.6e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 NM_052931.4_2 - 3.1e-05 23.8 0.1 0.013 15.5 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_052931.4_2 - 0.00014 22.0 2.1 0.012 15.8 0.3 2.6 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 NM_052931.4_2 - 0.00027 20.9 3.9 0.073 13.1 0.0 3.6 3 1 0 3 3 3 2 Immunoglobulin domain PKD_3 PF16820.3 NM_052931.4_2 - 0.061 13.0 0.0 0.17 11.5 0.0 1.8 1 0 0 1 1 1 0 PKD-like domain OAD_gamma PF04277.11 NM_052931.4_2 - 9.1 6.8 6.0 20 5.7 6.0 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain MFS_2 PF13347.4 NM_032793.4_2 - 1.5e-124 415.7 25.9 1.8e-124 415.5 25.9 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein DUF1201 PF06716.9 NM_032793.4_2 - 0.14 12.1 0.0 0.14 12.1 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1201) Cyt-b5 PF00173.26 NM_006667.4_3 - 5.8e-14 51.9 0.0 8.9e-14 51.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain SPRY PF00622.26 NM_014788.3_1 - 2.6e-14 53.2 0.0 4.6e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 NM_014788.3_1 - 2.4e-10 40.3 0.8 7.6e-10 38.7 0.8 1.8 1 0 0 1 1 1 1 B-box zinc finger PRY PF13765.4 NM_014788.3_1 - 4e-09 35.8 0.2 1.2e-08 34.3 0.2 1.9 1 0 0 1 1 1 1 SPRY-associated domain DUF3919 PF13057.4 NM_014788.3_1 - 0.69 9.3 2.2 1 8.8 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) RNase_H PF00075.22 NM_001286834.1_1 - 5.6e-44 149.7 0.0 8.8e-44 149.0 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 NM_001286834.1_1 - 5.9e-19 68.0 0.9 1.2e-18 66.9 0.9 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 NM_001286834.1_1 - 0.012 15.2 0.0 0.023 14.3 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like SRTM1 PF15872.3 NM_203451.2_3 - 2.6e-54 181.6 11.3 5.3e-54 180.6 11.3 1.5 1 0 0 1 1 1 1 Serine-rich and transmembrane domain-containing protein 1 Acyl-CoA_dh_1 PF00441.22 NM_000016.5_1 - 1.6e-48 164.6 4.0 2.3e-48 164.1 4.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.14 NM_000016.5_1 - 6.3e-28 97.6 0.1 1.1e-27 96.8 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.17 NM_000016.5_1 - 4.4e-27 94.0 0.0 8e-27 93.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 NM_000016.5_1 - 3.7e-20 72.4 1.0 6e-20 71.8 1.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.6 NM_000016.5_1 - 0.00018 21.2 0.0 0.00042 19.9 0.0 1.7 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal adh_short_C2 PF13561.4 NM_021004.3_1 - 2.3e-63 213.7 0.1 3.1e-63 213.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 NM_021004.3_1 - 1.5e-53 181.0 0.3 1.9e-53 180.7 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 NM_021004.3_1 - 3.7e-11 43.1 0.3 5.5e-11 42.6 0.3 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.8 NM_021004.3_1 - 0.012 14.8 0.0 0.017 14.4 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DFP PF04127.13 NM_021004.3_1 - 0.036 13.8 0.3 0.059 13.1 0.3 1.4 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein YjeF_N PF03853.13 NM_021004.3_1 - 0.07 12.9 0.2 0.11 12.3 0.2 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus DUF5037 PF16440.3 NM_021004.3_1 - 0.1 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5037) GTF2I PF02946.12 NM_032999.3_2 - 1.3e-186 604.9 12.3 8.6e-32 108.9 0.0 6.3 6 0 0 6 6 6 6 GTF2I-like repeat Reprolysin PF01421.17 NM_021794.3_3 - 6.4e-36 124.0 0.0 6.4e-36 124.0 0.0 1.9 2 0 0 2 2 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_021794.3_3 - 1.6e-29 102.5 3.0 1.6e-29 102.5 3.0 4.1 3 2 1 4 4 2 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 NM_021794.3_3 - 3.8e-22 78.9 0.0 9.9e-22 77.5 0.0 1.7 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 NM_021794.3_3 - 1.6e-20 73.6 31.7 1.6e-20 73.6 31.7 3.9 4 1 0 4 4 2 1 Disintegrin Reprolysin_5 PF13688.4 NM_021794.3_3 - 2.2e-09 37.6 0.0 6.5e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 DUF1510 PF07423.9 NM_021794.3_3 - 0.00099 18.5 5.6 0.0014 18.0 5.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) SpoIIIAH PF12685.5 NM_021794.3_3 - 0.001 18.8 0.6 0.0017 18.1 0.6 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein DUF4834 PF16118.3 NM_021794.3_3 - 0.0012 19.7 2.1 0.0023 18.8 2.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Reprolysin_3 PF13582.4 NM_021794.3_3 - 0.01 16.2 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like ATP-synt_B PF00430.16 NM_021794.3_3 - 0.019 14.9 2.0 0.028 14.4 2.0 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Reprolysin_4 PF13583.4 NM_021794.3_3 - 0.034 13.7 0.7 0.09 12.3 0.1 1.8 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Zip PF02535.20 NM_021794.3_3 - 0.041 13.0 0.0 0.057 12.5 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Reprolysin_2 PF13574.4 NM_021794.3_3 - 0.071 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Neur_chan_memb PF02932.14 NM_021794.3_3 - 0.1 12.5 0.6 0.16 11.8 0.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.15 NM_021794.3_3 - 4.2 5.9 6.5 6.3 5.3 6.5 1.2 1 0 0 1 1 1 0 Presenilin Defensin_1 PF00323.17 NM_001204477.1_2 - 0.024 15.0 1.1 0.15 12.5 1.1 2.4 1 0 0 1 1 1 0 Mammalian defensin CDRT4 PF15213.4 NM_001204477.1_3 - 9.8e-70 233.4 1.9 1.5e-69 232.8 1.9 1.3 1 0 0 1 1 1 1 CMT1A duplicated region transcript 4 protein MBOAT PF03062.17 NM_024298.4_3 - 5e-31 108.2 10.9 7.8e-31 107.5 10.9 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF1925 PF09094.9 NM_024298.4_3 - 0.13 12.4 0.7 0.26 11.5 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) MARVEL PF01284.21 NM_001290191.1_2 - 1.1e-34 119.4 32.2 7.7e-20 71.3 5.7 3.1 2 0 0 2 2 2 2 Membrane-associating domain I-set PF07679.14 NM_001243271.1_1 - 1.1e-81 268.9 0.0 8.3e-16 57.7 0.0 6.3 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001243271.1_1 - 1.7e-78 259.1 1.6 5.4e-14 52.4 0.0 6.8 7 0 0 7 7 6 6 Immunoglobulin domain Ig_2 PF13895.4 NM_001243271.1_1 - 3.2e-58 193.9 0.1 3.4e-11 43.2 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 NM_001243271.1_1 - 1.3e-45 153.3 0.0 9.9e-10 38.3 0.0 6.6 6 1 0 6 6 6 6 Immunoglobulin domain V-set PF07686.15 NM_001243271.1_1 - 1.9e-23 82.6 7.1 0.0032 17.5 0.0 10.4 6 5 2 8 8 8 5 Immunoglobulin V-set domain fn3 PF00041.19 NM_001243271.1_1 - 3.4e-21 75.3 2.5 4e-12 46.2 0.1 3.5 3 0 0 3 3 3 3 Fibronectin type III domain Ig_5 PF16681.3 NM_001243271.1_1 - 2.2e-10 40.7 0.0 0.16 12.3 0.0 5.5 6 0 0 6 6 6 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 NM_001243271.1_1 - 9e-09 35.2 0.1 0.62 10.0 0.0 4.8 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 NM_001243271.1_1 - 4e-08 33.4 0.0 1.4 9.2 0.0 4.7 4 0 0 4 4 4 3 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 NM_001243271.1_1 - 2.6e-05 24.0 0.0 11 6.1 0.0 5.5 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain C2-set PF05790.13 NM_001243271.1_1 - 0.00014 21.8 0.0 0.26 11.4 0.0 3.9 4 0 0 4 4 4 1 Immunoglobulin C2-set domain Herpes_gE PF02480.14 NM_001243271.1_1 - 0.0017 17.1 0.1 1.7 7.2 0.0 3.4 3 1 1 4 4 4 2 Alphaherpesvirus glycoprotein E Neurexophilin PF06312.10 NM_152315.3_2 - 4.3e-20 71.9 0.0 9.6e-20 70.8 0.0 1.6 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.17 NM_152315.3_2 - 0.003 18.2 0.0 0.098 13.4 0.0 2.3 2 0 0 2 2 2 1 Filamin/ABP280 repeat VP_N-CPKC PF11475.6 NM_000958.2_1 - 0.014 15.1 0.5 0.029 14.1 0.5 1.5 1 0 0 1 1 1 0 Virion protein N terminal domain 7tm_1 PF00001.19 NM_000958.2_2 - 1.4e-33 116.2 5.9 1.9e-33 115.7 5.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) NdhL PF10716.7 NM_000958.2_2 - 0.018 14.9 0.8 0.05 13.4 0.0 2.1 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit Gtr1_RagA PF04670.10 NM_006570.4_2 - 2.1e-108 360.9 0.8 2.6e-108 360.6 0.8 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.20 NM_006570.4_2 - 3.8e-08 33.0 0.0 7.4e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_006570.4_2 - 4.8e-08 33.1 0.0 1.1e-07 31.9 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_006570.4_2 - 6.9e-08 32.0 0.0 1.3e-07 31.1 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_006570.4_2 - 3.9e-06 26.8 0.0 9.5e-06 25.6 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.8 NM_006570.4_2 - 0.019 14.2 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.25 NM_006570.4_2 - 0.057 13.8 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 ABC transporter DUF815 PF05673.11 NM_006570.4_2 - 0.065 12.2 1.7 0.32 10.0 0.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF815) PduV-EutP PF10662.7 NM_006570.4_2 - 0.068 12.8 0.2 0.16 11.5 0.1 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF258 PF03193.14 NM_006570.4_2 - 0.11 12.3 0.1 3.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SecA_DEAD PF07517.12 NM_006570.4_2 - 0.11 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 SecA DEAD-like domain DEAD PF00270.27 NM_006570.4_2 - 0.13 11.9 0.0 0.28 10.8 0.0 1.3 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_24 PF13479.4 NM_006570.4_2 - 0.17 11.5 0.1 0.28 10.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.18 NM_006570.4_2 - 1.2 8.1 6.0 3 6.8 0.3 2.7 2 1 1 3 3 3 0 G-protein alpha subunit Lon_C PF05362.11 NM_001300948.1_1 - 2.7e-80 268.6 0.0 4e-80 268.1 0.0 1.2 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.27 NM_001300948.1_1 - 1.2e-20 74.1 0.0 2.2e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.14 NM_001300948.1_1 - 3.3e-13 49.8 0.0 6.4e-13 48.9 0.0 1.5 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.12 NM_001300948.1_1 - 4.1e-08 33.2 0.0 7.1e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.4 NM_001300948.1_1 - 5.8e-05 22.8 0.0 0.00011 21.9 0.0 1.5 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.4 NM_001300948.1_1 - 0.00062 20.0 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_3 PF07726.9 NM_001300948.1_1 - 0.0011 18.7 0.0 0.0023 17.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.12 NM_001300948.1_1 - 0.0048 16.9 0.0 0.0087 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.4 NM_001300948.1_1 - 0.0071 16.5 0.0 0.035 14.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_PrkA PF08298.9 NM_001300948.1_1 - 0.011 14.6 0.0 0.068 11.9 0.0 2.0 2 0 0 2 2 2 0 PrkA AAA domain DUF258 PF03193.14 NM_001300948.1_1 - 0.029 14.1 0.0 0.054 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 TIP49 PF06068.11 NM_001300948.1_1 - 0.035 12.9 0.1 4.7 5.9 0.0 2.2 2 0 0 2 2 2 0 TIP49 C-terminus AAA_18 PF13238.4 NM_001300948.1_1 - 0.048 14.0 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.10 NM_001300948.1_1 - 0.05 12.7 0.0 0.16 11.1 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus SKI PF01202.20 NM_001300948.1_1 - 0.088 12.8 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 Shikimate kinase NACHT PF05729.10 NM_001300948.1_1 - 0.11 12.3 0.9 26 4.6 0.3 3.2 3 0 0 3 3 3 0 NACHT domain AAA_33 PF13671.4 NM_001300948.1_1 - 0.21 11.6 0.8 0.3 11.1 0.0 1.6 2 0 0 2 2 1 0 AAA domain zf-RING_5 PF14634.4 NM_001193318.2_2 - 7.9e-09 35.2 13.5 7.9e-09 35.2 13.5 2.6 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.4 NM_001193318.2_2 - 0.054 13.2 16.3 0.19 11.5 8.0 3.6 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.4 NM_001193318.2_2 - 0.43 10.5 14.4 0.28 11.1 9.1 3.0 2 1 0 2 2 2 0 RING-type zinc-finger E1-E2_ATPase PF00122.18 NM_001001485.2_3 - 1.5e-60 204.1 0.9 3.4e-60 203.0 0.9 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 NM_001001485.2_3 - 2.5e-41 141.2 1.6 2.5e-41 141.2 1.6 2.3 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.24 NM_001001485.2_3 - 1.9e-22 80.5 2.2 7.1e-22 78.6 2.2 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 NM_001001485.2_3 - 5.5e-18 64.3 0.0 1.2e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.4 NM_001001485.2_3 - 7.7e-17 61.0 0.0 3.1e-15 55.9 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.10 NM_001001485.2_3 - 0.0003 20.5 2.7 0.00059 19.5 2.7 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HLH PF00010.24 NM_198205.1_3 - 1.1e-15 57.2 0.1 2.2e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RSN1_7TM PF02714.13 NM_014698.2_2 - 5.4e-55 186.5 24.2 1.1e-54 185.5 24.2 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.4 NM_014698.2_2 - 3.8e-44 150.9 0.3 5.4e-44 150.4 0.3 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.4 NM_014698.2_2 - 1.8e-20 73.2 1.5 1.8e-20 73.2 1.5 4.1 4 0 0 4 4 4 2 Late exocytosis, associated with Golgi transport RRM_1 PF00076.20 NM_014698.2_2 - 0.0011 18.6 0.0 0.75 9.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-HC5HC2H PF13771.4 NM_001320727.1_1 - 7.1e-19 67.7 8.1 2e-18 66.3 4.2 3.1 2 0 0 2 2 2 1 PHD-like zinc-binding domain Pre-SET PF05033.14 NM_001320727.1_1 - 4.7e-15 56.0 7.8 4.7e-15 56.0 7.8 3.5 3 1 0 3 3 3 1 Pre-SET motif MBD PF01429.17 NM_001320727.1_1 - 1.2e-07 31.2 0.0 3.3e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Methyl-CpG binding domain zf-HC5HC2H_2 PF13832.4 NM_001320727.1_1 - 8.9e-07 28.9 8.5 5.1e-06 26.5 7.5 2.7 1 1 1 2 2 2 1 PHD-zinc-finger like domain SET PF00856.26 NM_001320727.1_1 - 1.7e-05 25.2 0.3 5.5e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 SET domain GLTSCR1 PF15249.4 NM_015349.2_2 - 2.3e-30 104.9 2.0 4.6e-30 104.0 2.0 1.5 1 0 0 1 1 1 1 Conserved region of unknown function on GLTSCR protein Casc1_N PF15927.3 NM_001082972.2_2 - 3.5e-62 209.5 21.1 3.5e-62 209.5 21.1 2.4 2 0 0 2 2 2 1 Cancer susceptibility candidate 1 N-terminus BCDHK_Adom3 PF10436.7 NM_001199900.1_3 - 2.5e-50 170.3 0.0 3.3e-50 169.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase XRCC4 PF06632.10 NM_001318012.1_1 - 2.3e-156 519.7 9.4 2.8e-156 519.4 9.4 1.1 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF927 PF06048.9 NM_001318012.1_1 - 0.078 12.3 0.3 0.12 11.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF927) A_deamin PF02137.16 NM_001324452.1_1 - 0.069 12.5 0.7 0.096 12.0 0.7 1.2 1 0 0 1 1 1 0 Adenosine-deaminase (editase) domain A_deamin PF02137.16 NM_001324452.1_3 - 6.7e-97 324.7 0.0 9.7e-97 324.2 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain KRAB PF01352.25 NM_001202473.1_1 - 7.9e-22 76.5 0.1 1.5e-21 75.6 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 NM_001202473.1_2 - 1.9e-19 69.0 41.1 3e-05 24.1 5.5 6.6 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001202473.1_2 - 3.8e-10 39.5 35.5 0.00035 20.7 5.8 6.3 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001202473.1_2 - 0.28 12.0 37.2 0.54 11.1 4.9 5.9 6 0 0 6 6 6 0 C2H2-type zinc finger zf-LYAR PF08790.9 NM_001202473.1_2 - 7.1 6.5 9.5 3.7 7.4 1.4 3.5 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Asp PF00026.21 NM_004851.2_3 - 3.9e-103 345.0 0.0 4.6e-103 344.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 NM_004851.2_3 - 4.2e-12 46.6 0.0 5.4e-10 39.7 0.0 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 NM_004851.2_3 - 0.064 13.0 0.8 0.12 12.2 0.8 1.4 1 0 0 1 1 1 0 A1 Propeptide SAPS PF04499.13 NM_001164163.1_1 - 5.7e-104 348.5 10.9 9e-66 222.5 5.2 3.3 3 1 1 4 4 4 2 SIT4 phosphatase-associated protein STAG PF08514.9 NM_001282718.1_1 - 1.2e-35 121.6 0.0 4e-35 120.0 0.0 1.9 1 0 0 1 1 1 1 STAG domain Cnd1 PF12717.5 NM_001282718.1_1 - 0.00018 21.4 0.1 0.045 13.6 0.0 2.7 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 NM_001282718.1_1 - 0.042 14.0 0.2 10 6.5 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat VPS13_mid_rpt PF16910.3 NM_017684.4_2 - 7.6e-93 310.1 34.4 2.1e-68 230.1 3.2 7.6 5 3 0 5 5 5 4 Repeating coiled region of VPS13 VPS13 PF16908.3 NM_017684.4_2 - 2.3e-66 223.9 18.3 1.8e-65 221.0 4.6 5.0 6 0 0 6 6 6 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.3 NM_017684.4_2 - 8.2e-65 217.7 3.8 6.3e-62 208.3 0.1 3.0 2 1 1 3 3 3 3 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.5 NM_017684.4_2 - 5.1e-36 123.2 0.9 5.1e-36 123.2 0.9 3.3 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.10 NM_017684.4_2 - 3.1e-31 108.6 0.0 1.2e-29 103.4 0.0 2.8 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.9 NM_017684.4_2 - 4.2e-10 39.7 0.1 2.7e-09 37.1 0.0 2.5 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain WWE PF02825.18 NM_017684.4_2 - 0.00088 19.6 0.1 0.0044 17.4 0.1 2.3 1 0 0 1 1 1 1 WWE domain MAGP PF05507.9 NM_001297709.1_1 - 4.9e-56 188.7 0.3 6.7e-56 188.3 0.3 1.2 1 0 0 1 1 1 1 Microfibril-associated glycoprotein (MAGP) FGF PF00167.16 NM_001139502.1_3 - 5.6e-42 142.7 0.2 8.9e-42 142.0 0.2 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 NM_001139502.1_3 - 0.016 15.3 0.0 0.057 13.5 0.0 1.8 2 0 0 2 2 2 0 Fascin domain PAC3 PF10178.7 NM_032302.3_1 - 1.1e-26 92.6 0.1 2e-26 91.8 0.1 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 ANF_receptor PF01094.26 NM_001319053.1_1 - 5.8e-71 239.3 0.0 7.5e-71 238.9 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 NM_001319053.1_1 - 5.7e-52 176.7 4.1 5.7e-52 176.7 4.1 1.8 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR Peripla_BP_6 PF13458.4 NM_001319053.1_1 - 1.5e-19 70.8 0.0 2.3e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein DUF3995 PF13160.4 NM_001319053.1_1 - 0.017 15.3 1.1 0.047 13.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3995) Kei1 PF08552.9 NM_001319053.1_1 - 0.03 13.9 1.0 1.1 8.8 0.1 2.5 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 PKcGMP_CC PF16808.3 NM_001319053.1_1 - 0.15 11.8 6.5 0.36 10.6 6.5 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Sushi PF00084.18 NM_001319053.1_2 - 0.00081 19.8 0.2 0.043 14.3 0.1 2.6 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) LIM_bind PF01803.14 NM_001304434.1_1 - 4.8e-54 183.3 9.7 2.1e-43 148.5 0.5 2.5 2 1 1 3 3 3 2 LIM-domain binding protein Sulfotransfer_1 PF00685.25 NM_177528.2_1 - 1.5e-84 283.5 0.1 1.7e-84 283.3 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_177528.2_1 - 5.4e-09 36.6 0.0 5.7e-05 23.5 0.1 2.2 1 1 1 2 2 2 2 Sulfotransferase family Syntaxin PF00804.23 NM_177528.2_1 - 0.11 12.0 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 Syntaxin Pkinase PF00069.23 NM_021643.3_3 - 4.6e-34 117.9 0.0 6.4e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_021643.3_3 - 6.6e-17 61.5 0.0 9.4e-17 61.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_021643.3_3 - 0.00016 21.0 0.0 0.00023 20.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like DAGK_acc PF00609.17 NM_003646.3_3 - 1.2e-46 158.8 0.0 2.1e-46 158.0 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 NM_003646.3_3 - 3.7e-29 100.8 0.0 7.8e-29 99.7 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ank_2 PF12796.5 NM_003646.3_3 - 3.6e-12 46.5 0.1 6.8e-12 45.7 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) C1_1 PF00130.20 NM_003646.3_3 - 3.8e-12 45.8 26.4 4.4e-10 39.2 13.8 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_5 PF13857.4 NM_003646.3_3 - 1.6e-10 40.9 0.1 0.00014 22.0 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_003646.3_3 - 8e-09 34.9 0.3 0.0049 17.1 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 NM_003646.3_3 - 1.6e-08 34.8 0.5 1.4e-05 25.4 0.1 2.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_003646.3_3 - 2.3e-05 24.5 0.5 0.078 13.3 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat HIP1_clath_bdg PF16515.3 NM_031919.4_2 - 0.0047 17.4 8.3 0.18 12.3 0.3 2.1 2 0 0 2 2 2 2 Clathrin-binding domain of Huntingtin-interacting protein 1 IncA PF04156.12 NM_031919.4_2 - 0.036 13.7 8.6 0.052 13.2 8.6 1.2 1 0 0 1 1 1 0 IncA protein DUF2935 PF11155.6 NM_031919.4_2 - 0.065 13.4 2.2 0.1 12.8 1.5 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) Baculo_PEP_C PF04513.10 NM_031919.4_2 - 0.11 12.5 5.9 0.21 11.5 5.9 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CorA PF01544.16 NM_031919.4_2 - 0.13 11.4 2.4 0.19 10.9 2.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Serine_rich PF08824.8 NM_031919.4_2 - 0.13 12.1 3.7 0.17 11.7 3.7 1.1 1 0 0 1 1 1 0 Serine rich protein interaction domain CAP_N PF01213.17 NM_031919.4_2 - 0.15 11.4 1.2 0.19 11.0 1.2 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF5082 PF16888.3 NM_031919.4_2 - 0.25 11.5 12.1 3.6 7.8 11.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF1664 PF07889.10 NM_031919.4_2 - 0.26 11.2 6.1 0.46 10.4 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF148 PF02520.15 NM_031919.4_2 - 0.28 11.2 6.8 0.95 9.5 5.5 2.0 1 1 1 2 2 2 0 Domain of unknown function DUF148 Exonuc_VII_L PF02601.13 NM_031919.4_2 - 0.3 10.5 3.1 0.38 10.1 3.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.9 NM_031919.4_2 - 0.33 9.7 9.7 0.42 9.3 9.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein PP1_inhibitor PF05361.10 NM_031919.4_2 - 0.34 10.8 6.6 0.31 10.9 0.3 2.2 1 1 1 2 2 2 0 PKC-activated protein phosphatase-1 inhibitor MCU PF04678.11 NM_031919.4_2 - 0.35 10.9 1.4 0.51 10.3 1.4 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Snapin_Pallidin PF14712.4 NM_031919.4_2 - 0.36 11.2 5.8 0.68 10.3 4.8 1.9 1 1 0 1 1 1 0 Snapin/Pallidin NPV_P10 PF05531.10 NM_031919.4_2 - 0.48 10.8 4.3 7.2 7.0 4.3 2.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Med4 PF10018.7 NM_031919.4_2 - 0.6 9.6 4.9 0.83 9.2 4.9 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DNA_topoisoIV PF00521.18 NM_031919.4_2 - 0.66 8.7 4.0 0.81 8.4 4.0 1.1 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A Cep57_MT_bd PF06657.11 NM_031919.4_2 - 0.69 10.3 4.9 1.4 9.3 1.9 2.2 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 TMPIT PF07851.11 NM_031919.4_2 - 1.6 7.8 6.4 1.9 7.5 5.6 1.5 1 1 1 2 2 2 0 TMPIT-like protein Prefoldin PF02996.15 NM_031919.4_2 - 2.3 8.0 7.5 2 8.2 0.3 2.6 1 1 0 2 2 2 0 Prefoldin subunit Tropomyosin_1 PF12718.5 NM_031919.4_2 - 2.9 7.9 10.2 10 6.1 0.2 2.1 1 1 1 2 2 2 0 Tropomyosin like Syntaxin-6_N PF09177.9 NM_031919.4_2 - 3.2 8.2 6.3 7 7.1 0.6 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal 4F5 PF04419.12 NM_022978.2_1 - 4.4e-10 40.1 11.8 8.3e-10 39.2 11.8 1.4 1 0 0 1 1 1 1 4F5 protein family TOM_sub5 PF15178.4 NM_022978.2_2 - 2.2e-22 78.6 0.6 3.3e-22 78.1 0.6 1.3 1 0 0 1 1 1 1 Mitochondrial import receptor subunit TOM5 homolog Complex1_LYR PF05347.13 NM_001278645.1_3 - 5.2e-05 23.1 1.5 7.3e-05 22.6 0.1 1.8 2 0 0 2 2 2 1 Complex 1 protein (LYR family) TPX2 PF06886.9 NM_001278645.1_3 - 0.54 10.4 9.5 1.4 9.1 3.7 2.3 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) UAA PF08449.9 NM_001286513.1_1 - 7.9e-73 245.2 11.5 1e-72 244.8 11.5 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.18 NM_001286513.1_1 - 3.5e-07 30.3 19.6 0.00016 21.7 12.5 2.5 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.8 NM_001286513.1_1 - 0.045 12.6 9.6 0.14 10.9 1.0 2.1 2 0 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like DUF2070 PF09843.7 NM_001286513.1_1 - 1.2 7.2 6.7 1.8 6.6 6.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MBT PF02820.16 NM_173464.3_1 - 5.1e-92 302.1 4.4 6.8e-31 106.3 0.1 3.4 3 0 0 3 3 3 3 mbt repeat SAM_1 PF00536.28 NM_173464.3_1 - 6.8e-15 55.1 0.0 1.2e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C2HC PF01530.16 NM_173464.3_1 - 2.3e-12 46.7 9.9 6e-12 45.4 9.9 1.8 1 0 0 1 1 1 1 Zinc finger, C2HC type SAM_2 PF07647.15 NM_173464.3_1 - 1.7e-06 27.9 0.0 3e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_173464.3_1 - 0.064 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Ste50p-SAM PF09235.8 NM_173464.3_1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Ste50p, sterile alpha motif DUF3534 PF12053.6 NM_001184791.1_1 - 1.1e-57 194.2 1.3 1.8e-57 193.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3534) PDZ PF00595.22 NM_001184791.1_1 - 7.7e-37 125.4 5.3 7.6e-16 58.1 0.2 3.5 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001184791.1_1 - 1.5e-13 50.7 0.5 1.7e-05 24.9 0.1 3.8 3 1 0 3 3 3 3 PDZ domain SynMuv_product PF06047.9 NM_024528.3_3 - 1.3e-49 166.4 1.6 1.3e-49 166.4 1.6 3.1 3 0 0 3 3 3 1 Ras-induced vulval development antagonist NKAP PF15692.3 NM_024528.3_3 - 9.4e-08 32.6 33.6 9.4e-08 32.6 33.6 5.9 4 3 1 5 5 5 1 NF-kappa-B-activating protein SR-25 PF10500.7 NM_024528.3_3 - 0.0053 16.3 50.0 0.0053 16.3 50.0 3.1 3 1 0 3 3 3 1 Nuclear RNA-splicing-associated protein Dsh_C PF12316.6 NM_024528.3_3 - 0.28 11.5 35.9 0.028 14.7 17.7 2.5 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal GREB1 PF15782.3 NM_024528.3_3 - 0.3 8.0 16.8 0.41 7.6 16.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC27 PF09507.8 NM_024528.3_3 - 0.7 9.1 46.1 0.066 12.5 41.5 1.6 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Mitofilin PF09731.7 NM_024528.3_3 - 5.3 5.6 30.2 9.1 4.8 30.2 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Vinculin PF01044.17 NM_001323999.1_2 - 3.4e-211 704.0 23.7 4.2e-211 703.7 23.7 1.0 1 0 0 1 1 1 1 Vinculin family I_LWEQ PF01608.15 NM_001323999.1_2 - 0.23 11.6 0.1 0.23 11.6 0.1 5.1 3 3 1 5 5 5 0 I/LWEQ domain F420_oxidored PF03807.15 NM_152999.3_1 - 2.7e-15 56.6 0.0 4.2e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.17 NM_152999.3_1 - 2.1e-12 47.2 6.4 2.1e-12 47.2 6.4 2.2 1 1 1 2 2 2 1 Ferric reductase like transmembrane component 2-Hacid_dh_C PF02826.17 NM_152999.3_1 - 0.028 13.7 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.13 NM_152999.3_1 - 0.03 14.4 0.0 0.044 13.8 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase zf-H2C2_2 PF13465.4 NM_001164276.1_2 - 1.3e-103 335.0 141.5 1e-08 35.1 2.6 17.5 17 0 0 17 17 17 16 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001164276.1_2 - 1.5e-61 201.4 138.6 1.1e-05 25.5 0.1 17.0 17 0 0 17 17 17 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001164276.1_2 - 3.3e-48 158.0 136.0 0.00069 20.1 1.2 17.1 17 0 0 17 17 16 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001164276.1_2 - 1.2e-26 91.9 113.1 2e-06 27.5 1.3 17.2 16 1 0 16 16 16 12 C2H2-type zinc finger KRAB PF01352.25 NM_001164276.1_2 - 6.8e-21 73.5 0.0 1.2e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001164276.1_2 - 2.8e-17 62.4 85.5 0.0051 16.9 0.1 16.2 16 0 0 16 16 16 7 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001164276.1_2 - 2.4e-08 33.8 89.0 0.013 15.4 2.2 12.9 6 3 11 17 17 17 12 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001164276.1_2 - 4.5e-07 29.4 80.8 0.00042 19.9 0.0 12.9 15 0 0 15 15 15 6 zinc-finger C2H2-type C1_4 PF07975.10 NM_001164276.1_2 - 0.0051 16.9 0.7 0.0051 16.9 0.7 10.3 5 3 5 11 11 11 4 TFIIH C1-like domain Soc PF16855.3 NM_001164276.1_2 - 0.016 15.6 0.1 9.9 6.6 0.0 3.7 3 1 1 4 4 4 0 Small outer capsid protein zf-met PF12874.5 NM_001164276.1_2 - 0.02 15.1 0.0 0.02 15.1 0.0 13.2 14 0 0 14 14 13 0 Zinc-finger of C2H2 type FYVE PF01363.19 NM_001164276.1_2 - 0.57 10.2 82.4 0.33 11.0 4.8 10.1 1 1 5 6 6 6 0 FYVE zinc finger DUF3268 PF11672.6 NM_001164276.1_2 - 1.4 9.1 51.9 1.3 9.2 1.4 8.2 7 2 2 9 9 9 0 zinc-finger-containing domain zf-H2C2_2 PF13465.4 NM_001164276.1_3 - 0.074 13.4 2.1 0.079 13.3 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger double domain FYVE PF01363.19 NM_144588.6_3 - 4.2e-08 33.1 12.6 4.2e-08 33.1 12.6 1.8 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.14 NM_144588.6_3 - 0.0011 19.0 6.8 0.0011 19.0 6.8 1.8 2 0 0 2 2 2 1 FYVE-type zinc finger IBR PF01485.19 NM_144588.6_3 - 1.3 9.1 12.9 0.33 11.1 9.0 2.0 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Guanylate_kin PF00625.19 NM_001364.3_1 - 7.2e-65 218.0 0.1 1e-64 217.4 0.1 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 NM_001364.3_1 - 2.3e-64 213.6 8.3 4.1e-21 75.0 0.1 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) MAGUK_N_PEST PF10608.7 NM_001364.3_1 - 4e-32 111.0 5.5 6.6e-19 68.4 0.3 2.5 1 1 1 2 2 2 2 Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_assoc PF10600.7 NM_001364.3_1 - 9.2e-23 80.7 7.9 9.2e-23 80.7 7.9 2.3 2 0 0 2 2 2 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 NM_001364.3_1 - 1.4e-15 57.2 1.9 0.0004 20.5 0.0 3.4 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.15 NM_001364.3_1 - 2.1e-08 33.6 0.0 4.6e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001364.3_1 - 8.6e-08 31.5 0.0 1.6e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001364.3_1 - 0.009 15.7 0.0 0.023 14.4 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Peptidase_M14 PF00246.22 NM_001286715.1_2 - 1.2e-13 51.4 0.0 2.2e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.12 NM_001286715.1_2 - 0.00099 18.1 0.0 0.0017 17.4 0.0 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family V-ATPase_H_N PF03224.12 NM_001286715.1_2 - 0.053 12.7 3.9 0.018 14.2 0.5 1.9 2 1 0 2 2 2 0 V-ATPase subunit H Aminotran_1_2 PF00155.19 NM_001122671.1_3 - 1.9e-54 185.1 0.0 2.2e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.18 NM_001122671.1_3 - 0.0012 17.3 0.0 0.0037 15.7 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.15 NM_001122671.1_3 - 0.026 13.7 0.0 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.19 NM_001122671.1_3 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Mago_nashi PF02792.12 NM_001319985.1_3 - 1.5e-60 203.2 0.0 2.3e-60 202.7 0.0 1.2 1 0 0 1 1 1 1 Mago nashi protein TruD PF01142.16 NM_001098614.2_3 - 2.4e-73 247.2 0.0 1.5e-69 234.7 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) R3H PF01424.20 NM_001098614.2_3 - 0.071 13.0 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 R3H domain PAF PF15715.3 NM_001029989.2_2 - 1.8e-12 47.5 3.6 1.8e-12 47.5 3.6 1.8 2 0 0 2 2 2 1 PCNA-associated factor PDZ PF00595.22 NM_003257.4_2 - 3.4e-47 158.6 7.7 4e-16 59.0 0.2 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) ZU5 PF00791.18 NM_003257.4_2 - 7.2e-31 106.3 0.0 2.6e-30 104.5 0.0 1.9 2 0 0 2 2 2 1 ZU5 domain PDZ_2 PF13180.4 NM_003257.4_2 - 5e-17 61.8 4.7 3.7e-05 23.8 0.1 3.5 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.19 NM_003257.4_2 - 7.2e-13 48.5 0.0 1.2e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.15 NM_003257.4_2 - 7.3e-11 41.5 0.1 1.8e-10 40.2 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_003257.4_2 - 0.0034 16.8 0.1 0.026 14.0 0.0 2.6 2 0 0 2 2 2 1 SH3 domain RPOL_N PF14700.4 NM_003257.4_2 - 0.11 11.7 0.8 0.53 9.5 0.1 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal DAOA PF15199.4 NM_001161812.1_1 - 1.2e-40 137.7 0.4 1.9e-40 137.0 0.4 1.3 1 0 0 1 1 1 1 D-amino acid oxidase activator DAOA PF15199.4 NM_001161812.1_3 - 1.8e-11 44.2 0.8 2.9e-11 43.5 0.8 1.3 1 0 0 1 1 1 1 D-amino acid oxidase activator RRM_1 PF00076.20 NM_001324242.1_1 - 4.8e-09 35.8 0.0 9.8e-09 34.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HAUS2 PF15003.4 NM_001323631.1_1 - 2.1e-18 66.6 0.0 3e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 HAUS2 PF15003.4 NM_001323631.1_3 - 2.3e-39 135.0 3.9 3.2e-39 134.5 3.9 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 Vac_Fusion PF02346.14 NM_001323631.1_3 - 0.15 11.6 0.7 0.43 10.1 0.7 1.7 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 Homeobox PF00046.27 NM_001136271.2_1 - 5.8e-21 73.9 4.4 1.1e-20 73.0 4.4 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_001136271.2_1 - 0.11 12.3 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 Homeobox KN domain APC_basic PF05956.9 NM_005883.2_2 - 3.7e-110 368.5 47.1 3.7e-110 368.5 47.1 4.7 6 0 0 6 6 3 1 APC basic domain APC_N_CC PF16689.3 NM_005883.2_2 - 1.4e-30 104.9 2.9 3.9e-30 103.5 2.9 1.8 1 0 0 1 1 1 1 Coiled-coil N-terminus of APC, dimerisation domain Suppressor_APC PF11414.6 NM_005883.2_2 - 3.2e-25 87.8 5.2 1.1e-24 86.2 5.2 2.0 1 0 0 1 1 1 1 Adenomatous polyposis coli tumour suppressor protein APC_r PF05923.10 NM_005883.2_2 - 4.3e-23 80.3 35.8 4.8e-06 26.0 0.2 5.8 5 0 0 5 5 5 5 APC repeat Arm_APC_u3 PF16629.3 NM_005883.2_2 - 7.5e-23 81.4 0.1 2.4e-22 79.7 0.1 1.8 1 1 0 1 1 1 1 Armadillo-associated region on APC Arm PF00514.21 NM_005883.2_2 - 4.2e-20 70.9 12.9 1.2e-07 31.4 0.2 6.7 6 0 0 6 6 6 4 Armadillo/beta-catenin-like repeat SAMP PF05924.9 NM_005883.2_2 - 3.1e-13 48.4 6.2 4.7e-06 25.6 0.1 2.9 3 0 0 3 3 3 2 SAMP Motif ZapB PF06005.10 NM_005883.2_2 - 0.0033 17.7 5.3 0.015 15.6 5.3 2.2 1 0 0 1 1 1 1 Cell division protein ZapB bZIP_1 PF00170.19 NM_005883.2_2 - 0.04 13.9 0.6 0.1 12.6 0.6 1.7 1 0 0 1 1 1 0 bZIP transcription factor Filament PF00038.19 NM_005883.2_2 - 0.27 10.7 8.0 0.61 9.5 8.0 1.4 1 1 0 1 1 1 0 Intermediate filament protein Herpes_BLRF2 PF05812.10 NM_005883.2_2 - 0.39 10.7 1.8 1.6 8.7 1.8 2.1 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein HALZ PF02183.16 NM_005883.2_2 - 0.52 10.4 2.3 0.6 10.2 0.2 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper JAKMIP_CC3 PF16034.3 NM_005883.2_2 - 0.96 9.2 9.8 0.24 11.2 6.1 1.8 2 0 0 2 2 2 0 JAKMIP CC3 domain JIP_LZII PF16471.3 NM_005883.2_2 - 3.4 7.8 7.4 0.4 10.7 1.6 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Sec2p PF06428.9 NM_005883.2_2 - 5.7 6.8 7.7 0.46 10.3 2.3 2.0 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p zf-H2C2_2 PF13465.4 NM_001203250.1_1 - 1.1e-78 256.2 128.4 1.7e-08 34.4 1.2 16.4 16 0 0 16 16 16 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001203250.1_1 - 6.6e-32 108.1 134.8 0.0003 20.9 2.5 17.1 17 0 0 17 17 17 13 Zinc finger, C2H2 type KRAB PF01352.25 NM_001203250.1_1 - 1.1e-24 85.6 0.3 1.9e-24 84.9 0.3 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001203250.1_1 - 1.9e-18 65.4 161.1 0.00068 20.1 2.4 17.9 20 0 0 20 20 20 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001203250.1_1 - 7.3e-14 51.2 107.5 2.4e-05 24.0 1.5 14.8 14 1 0 14 14 14 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001203250.1_1 - 0.0004 20.3 83.1 0.15 12.0 2.7 10.2 4 2 5 11 11 11 8 Zinc ribbon domain DUF3268 PF11672.6 NM_001203250.1_1 - 0.04 14.1 51.6 0.98 9.6 4.0 6.6 2 1 5 8 8 8 0 zinc-finger-containing domain zf-trcl PF13451.4 NM_001203250.1_1 - 0.51 10.1 66.4 11 5.9 0.3 12.0 9 3 2 11 11 11 0 Probable zinc-ribbon domain ADIP PF11559.6 NM_001287601.1_1 - 0.0028 17.6 1.5 0.0068 16.4 1.5 1.5 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding CLASP_N PF12348.6 NM_199280.2_1 - 2.9e-17 62.9 3.7 5.8e-17 61.9 1.3 2.1 2 0 0 2 2 2 1 CLASP N terminal RTP1_C1 PF10363.7 NM_199280.2_1 - 4.6e-07 29.9 2.6 0.13 12.3 0.2 4.3 2 2 0 2 2 2 2 Required for nuclear transport of RNA pol II C-terminus 1 UME PF08064.11 NM_199280.2_1 - 9.7e-05 22.1 1.3 0.0043 16.8 0.1 3.1 2 1 0 2 2 2 1 UME (NUC010) domain Vac14_Fab1_bd PF12755.5 NM_199280.2_1 - 0.00052 20.4 0.1 7 7.2 0.0 3.5 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region RIX1 PF08167.10 NM_199280.2_1 - 0.00053 19.6 0.2 0.18 11.4 0.0 3.0 2 1 1 3 3 3 1 rRNA processing/ribosome biogenesis HEAT_2 PF13646.4 NM_199280.2_1 - 0.006 16.8 3.5 0.82 10.0 0.1 4.4 4 2 2 6 6 6 1 HEAT repeats Dopey_N PF04118.12 NM_199280.2_1 - 0.013 14.5 3.5 0.29 10.1 0.1 2.6 2 1 0 2 2 2 0 Dopey, N-terminal ParcG PF10274.7 NM_199280.2_1 - 0.28 11.1 1.0 6.8 6.6 0.1 2.4 2 0 0 2 2 2 0 Parkin co-regulated protein HEAT PF02985.20 NM_199280.2_1 - 0.29 11.4 5.2 5.7 7.3 0.0 5.1 6 0 0 6 6 6 0 HEAT repeat UPF0688 PF15772.3 NM_207356.2_3 - 2.5e-113 378.0 12.6 3.3e-113 377.6 12.6 1.1 1 0 0 1 1 1 1 UPF0688 family SAPS PF04499.13 NM_014931.3_3 - 1.6e-102 343.7 9.0 2.5e-65 221.0 4.0 2.8 2 1 1 3 3 3 2 SIT4 phosphatase-associated protein SDA1 PF05285.10 NM_014931.3_3 - 7.7 5.7 10.1 13 5.0 10.1 1.3 1 0 0 1 1 1 0 SDA1 Tyrosinase PF00264.18 NM_001322184.1_1 - 2.3e-32 112.9 0.1 3.2e-32 112.5 0.1 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase PetG PF02529.13 NM_001322184.1_1 - 0.061 13.0 1.9 0.16 11.7 1.9 1.6 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit 5 MPC PF03650.11 NM_001143674.3_3 - 2.4e-38 130.5 0.4 3.9e-38 129.8 0.4 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) zf-H2C2_2 PF13465.4 NM_001260486.1_1 - 4.7e-75 244.8 95.3 3.9e-08 33.2 1.8 14.2 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001260486.1_1 - 1.5e-46 154.2 103.1 1.1e-05 25.5 1.8 14.0 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001260486.1_1 - 4e-26 89.3 96.3 0.0013 19.2 0.8 14.1 14 0 0 14 14 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_001260486.1_1 - 2.4e-23 81.4 0.1 6.8e-23 79.9 0.1 1.9 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001260486.1_1 - 4.6e-15 55.3 61.3 0.005 17.0 0.2 12.0 13 0 0 13 13 13 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001260486.1_1 - 3.7e-08 33.0 81.1 0.033 14.0 0.6 12.6 13 0 0 13 13 13 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001260486.1_1 - 1.7e-06 27.9 68.8 0.067 13.2 1.6 9.7 3 3 7 11 11 11 6 Zinc ribbon domain zf-met PF12874.5 NM_001260486.1_1 - 0.0006 20.0 79.3 0.053 13.8 1.3 11.6 13 0 0 13 13 13 5 Zinc-finger of C2H2 type DUF3268 PF11672.6 NM_001260486.1_1 - 0.00083 19.6 39.0 0.091 13.0 0.2 6.5 5 1 0 6 6 6 3 zinc-finger-containing domain BolA PF01722.16 NM_001260486.1_1 - 0.021 15.0 15.0 2 8.6 0.2 4.7 3 2 2 5 5 5 0 BolA-like protein ADK_lid PF05191.12 NM_001260486.1_1 - 0.035 14.0 57.6 0.046 13.6 0.5 9.9 8 2 0 8 8 8 0 Adenylate kinase, active site lid XPA_N PF01286.16 NM_001260486.1_1 - 0.73 9.8 66.5 6.9 6.7 0.4 13.3 13 0 0 13 13 13 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001260486.1_1 - 1.7 9.3 54.7 1.3 9.7 1.5 7.3 1 1 5 8 8 8 0 zinc-ribbon family DNase_II PF03265.13 NM_021233.2_1 - 7.9e-112 373.6 4.6 9.1e-112 373.4 4.6 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II RRM_1 PF00076.20 NM_054016.3_2 - 2e-18 65.9 0.0 3.5e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 NM_054016.3_2 - 0.00036 20.3 0.0 0.00073 19.3 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif HEAT PF02985.20 NM_015032.3_1 - 0.011 15.7 3.9 9.2 6.7 0.0 5.8 6 0 0 6 6 6 0 HEAT repeat Cnd1 PF12717.5 NM_015032.3_1 - 0.018 14.9 11.3 0.52 10.2 0.3 4.9 3 2 2 5 5 5 0 non-SMC mitotic condensation complex subunit 1 DUF4420 PF14390.4 NM_015032.3_1 - 0.042 13.0 0.2 0.99 8.5 0.0 2.5 3 0 0 3 3 3 0 Putative PD-(D/E)XK family member, (DUF4420) Kelch_1 PF01344.23 NM_001168301.1_2 - 2.8e-53 177.1 9.4 1.3e-11 43.7 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 NM_001168301.1_2 - 3.3e-32 109.6 7.3 4.1e-07 29.9 0.0 7.1 1 1 5 6 6 6 5 Kelch motif Kelch_3 PF13415.4 NM_001168301.1_2 - 3.4e-25 87.6 1.5 0.00016 21.7 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain BACK PF07707.13 NM_001168301.1_2 - 1e-24 86.4 0.1 2.3e-24 85.3 0.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 NM_001168301.1_2 - 3.6e-24 85.0 0.4 1e-23 83.5 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.13 NM_001168301.1_2 - 1.4e-22 78.6 6.2 0.00013 21.6 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.4 NM_001168301.1_2 - 5.7e-13 48.5 4.3 0.0018 18.0 0.0 5.4 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_001168301.1_2 - 3.7e-10 39.4 12.8 0.035 13.9 0.2 5.6 5 0 0 5 5 5 4 Kelch motif RHINO PF15319.4 NM_001252499.2_1 - 8e-103 343.7 9.7 9.7e-103 343.4 9.7 1.1 1 0 0 1 1 1 1 RAD9, RAD1, HUS1-interacting nuclear orphan protein PFK PF00365.18 NM_001166687.1_1 - 2.2e-201 666.8 6.8 2.9e-109 364.6 0.8 2.2 2 0 0 2 2 2 2 Phosphofructokinase Phage_TAC_14 PF16462.3 NM_001166687.1_1 - 0.12 12.5 0.0 0.36 10.9 0.0 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC Lig_chan PF00060.24 NM_001185090.1_1 - 1.3e-38 132.0 0.1 2.2e-38 131.3 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.26 NM_001185090.1_1 - 5.8e-36 124.2 0.0 3.4e-34 118.4 0.0 2.3 1 1 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.7 NM_001185090.1_1 - 5.4e-32 110.2 0.0 7e-31 106.6 0.0 2.2 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_001185090.1_1 - 8.6e-19 67.7 0.0 2.5e-18 66.2 0.0 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 CaM_bdg_C0 PF10562.7 NM_001185090.1_1 - 1.2e-13 50.6 3.9 3.4e-13 49.3 3.9 1.8 1 0 0 1 1 1 1 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit Ion_trans_2 PF07885.14 NM_001185090.1_1 - 0.084 12.7 0.5 0.19 11.6 0.5 1.6 1 0 0 1 1 1 0 Ion channel NAD_binding_4 PF07993.10 NM_001271784.1_3 - 3.9e-56 189.9 0.0 5.6e-56 189.4 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.17 NM_001271784.1_3 - 1.3e-31 108.5 0.7 2.8e-31 107.4 0.7 1.6 1 0 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.15 NM_001271784.1_3 - 0.0087 15.1 0.1 9 5.2 0.0 3.0 3 0 0 3 3 3 2 RmlD substrate binding domain Mis12 PF05859.10 NM_001258220.1_1 - 1.5e-27 96.2 1.0 2.4e-27 95.5 1.0 1.3 1 0 0 1 1 1 1 Mis12 protein Macro PF01661.19 NM_001146103.1_1 - 2.5e-48 162.9 0.5 1.5e-30 105.5 0.1 2.4 2 0 0 2 2 2 2 Macro domain PARP PF00644.18 NM_001146103.1_1 - 4.2e-05 23.1 0.1 0.0013 18.3 0.0 2.5 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain GCV_T_C PF08669.9 NM_001010867.3_1 - 8.9e-07 28.9 0.0 1.5e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain GCV_T PF01571.19 NM_001010867.3_1 - 0.0049 16.1 0.0 0.008 15.4 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain Ubiquitin_3 PF14836.4 NM_001252079.1_1 - 2.2e-39 133.1 0.1 3.5e-39 132.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.10 NM_001252079.1_1 - 2.5e-22 79.1 1.3 5.2e-22 78.1 1.3 1.5 1 0 0 1 1 1 1 DUSP domain USP7_ICP0_bdg PF12436.6 NM_001252079.1_1 - 0.0014 18.0 0.0 0.0021 17.4 0.0 1.1 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 DEAD PF00270.27 NM_016355.3_2 - 7.5e-48 162.5 0.1 1.1e-47 161.9 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_016355.3_2 - 6.1e-31 106.9 0.1 4e-30 104.3 0.0 2.4 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_016355.3_2 - 8.3e-06 25.8 0.0 1.5e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Pkinase PF00069.23 NM_001321177.1_3 - 1.2e-53 182.0 0.0 1.7e-53 181.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001321177.1_3 - 1.2e-39 136.1 0.0 1.7e-39 135.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001321177.1_3 - 4.6e-05 22.7 0.0 8.3e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 NM_001321177.1_3 - 0.0066 16.3 0.0 0.046 13.5 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Sulfate_transp PF00916.18 NM_001282356.1_3 - 4.4e-92 308.6 25.1 5.9e-92 308.2 25.1 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 NM_001282356.1_3 - 4.8e-18 64.8 0.0 8.3e-18 64.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.4 NM_001282356.1_3 - 0.024 14.8 0.0 0.047 13.9 0.0 1.4 1 0 0 1 1 1 0 STAS domain Corona_7 PF02398.14 NM_001172675.1_1 - 0.003 18.0 10.2 36 4.9 0.1 6.1 7 0 0 7 7 7 4 Coronavirus protein 7 zf-H2C2_2 PF13465.4 NM_001172675.1_2 - 0.012 15.9 0.7 0.012 15.9 0.7 2.1 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001172675.1_2 - 1.2 9.6 12.3 0.087 13.2 1.5 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001172675.1_3 - 1.7e-145 467.4 134.6 9e-09 35.3 0.5 20.9 21 0 0 21 21 20 20 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001172675.1_3 - 2.1e-113 364.8 145.1 9.2e-07 28.9 1.5 21.1 21 0 0 21 21 20 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001172675.1_3 - 4.6e-50 163.8 136.2 0.0015 19.1 0.9 21.2 21 0 0 21 21 21 17 C2H2-type zinc finger KRAB PF01352.25 NM_001172675.1_3 - 2.2e-25 87.9 0.2 2.2e-25 87.9 0.2 1.8 2 0 0 2 2 2 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001172675.1_3 - 7.5e-24 83.4 84.2 0.0075 16.2 3.4 14.3 7 6 9 16 16 16 14 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001172675.1_3 - 6.7e-21 73.6 123.3 0.22 11.4 0.2 19.7 18 4 0 18 18 18 17 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001172675.1_3 - 8.3e-20 70.1 88.0 0.12 12.0 0.2 18.6 19 0 0 19 19 18 12 zinc-finger C2H2-type XPA_N PF01286.16 NM_001172675.1_3 - 6.5e-13 48.3 52.2 6.5 6.7 0.1 17.9 18 0 0 18 18 18 2 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001172675.1_3 - 1.1e-08 35.6 73.7 0.51 11.0 3.6 10.0 1 1 13 14 14 14 10 zinc-ribbon family MRP-S23 PF10484.7 NM_001172675.1_3 - 0.00027 21.0 0.0 89 3.2 0.0 7.2 5 3 3 8 8 8 0 Mitochondrial ribosomal protein S23 Arc_trans_TRASH PF08394.8 NM_001172675.1_3 - 0.002 18.3 23.5 16 5.8 0.4 10.1 9 3 0 9 9 9 0 Archaeal TRASH domain ZZ PF00569.15 NM_001172675.1_3 - 0.015 14.9 80.3 20 5.0 0.1 18.1 18 0 0 18 18 18 0 Zinc finger, ZZ type C1_4 PF07975.10 NM_001172675.1_3 - 0.1 12.8 74.1 0.14 12.3 2.7 11.6 3 2 12 16 16 16 0 TFIIH C1-like domain zinc_ribbon_5 PF13719.4 NM_001172675.1_3 - 0.26 10.9 62.6 1.4 8.6 1.4 11.4 11 1 0 11 11 11 0 zinc-ribbon domain FerB PF08150.10 NM_001172675.1_3 - 6.3 7.4 21.6 35 5.0 0.1 6.9 4 2 2 7 7 6 0 FerB (NUC096) domain PAX PF00292.16 NM_001280553.1_2 - 3.7e-73 243.2 0.7 5.6e-73 242.6 0.7 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 NM_001280553.1_2 - 7.9e-23 80.6 26.2 2.2e-21 75.9 8.1 2.9 2 1 1 3 3 3 2 Paired-box protein 2 C terminal HTH_23 PF13384.4 NM_001280553.1_2 - 0.00099 18.7 0.0 0.0024 17.5 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.4 NM_001280553.1_2 - 0.036 14.6 0.0 0.036 14.6 0.0 3.6 3 1 1 4 4 4 0 Homeodomain-like domain Prion PF00377.16 NM_001271561.1_1 - 1.1e-34 118.6 2.4 1.7e-34 118.1 2.4 1.3 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 NM_001271561.1_1 - 7.5e-17 60.7 4.0 1.6e-16 59.7 4.0 1.6 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal Churchill PF06573.9 NM_001204064.1_1 - 6e-24 84.4 1.0 1.1e-23 83.6 1.0 1.3 1 0 0 1 1 1 1 Churchill protein Churchill PF06573.9 NM_001204064.1_2 - 6.8e-08 32.7 0.0 1.1e-07 32.1 0.0 1.3 1 0 0 1 1 1 1 Churchill protein DUF1725 PF08333.9 NM_001204064.1_3 - 0.0047 16.4 0.7 0.01 15.3 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) LRR_8 PF13855.4 NM_001243963.1_2 - 1.1e-24 85.8 8.1 9.2e-11 41.2 0.8 3.5 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_001243963.1_2 - 1.1e-13 51.0 14.8 0.0017 18.5 2.5 5.4 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) CH PF00307.29 NM_001243963.1_2 - 7.2e-09 35.7 0.0 1.6e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain LRR_1 PF00560.31 NM_001243963.1_2 - 0.16 12.4 19.4 9.4 7.0 0.5 7.3 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.4 NM_001243963.1_2 - 2.7 8.1 17.3 46 4.3 0.0 6.1 6 0 0 6 6 6 0 Leucine Rich repeat Ig_2 PF13895.4 NM_001002901.3_1 - 6.8e-22 77.5 0.0 2.5e-10 40.4 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 NM_001002901.3_1 - 1.1e-07 32.2 1.3 0.0035 17.8 0.0 3.7 4 1 0 4 4 4 2 Immunoglobulin domain ig PF00047.23 NM_153443.4_3 - 9.5e-27 92.9 0.0 3.6e-12 46.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_153443.4_3 - 2.3e-14 53.3 0.0 6e-07 29.6 0.0 3.8 3 2 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.4 NM_153443.4_3 - 4.4e-13 49.5 0.0 0.00083 19.8 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_153443.4_3 - 3.2e-05 23.9 0.1 3.5 7.7 0.0 4.6 4 1 1 5 5 5 2 Immunoglobulin V-set domain Pkinase PF00069.23 NM_001316327.1_1 - 3.2e-61 206.9 0.0 4.5e-61 206.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001316327.1_1 - 1.4e-38 132.6 0.0 2.7e-38 131.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 NM_001316327.1_1 - 3.7e-32 109.8 20.9 1.7e-17 62.9 7.6 2.9 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 NM_001316327.1_1 - 4.6e-09 36.7 0.8 9.1e-09 35.7 0.8 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_001316327.1_1 - 0.001 18.3 0.0 0.0021 17.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like C1_2 PF03107.14 NM_001316327.1_1 - 0.0016 18.6 3.1 0.0016 18.6 3.1 3.4 4 0 0 4 4 3 2 C1 domain zf-RING-like PF08746.9 NM_001316327.1_1 - 0.0018 18.4 18.7 0.054 13.7 6.7 3.0 2 0 0 2 2 2 2 RING-like domain Zf_RING PF16744.3 NM_001316327.1_1 - 0.0036 17.2 1.4 0.0036 17.2 1.4 2.6 2 0 0 2 2 2 1 KIAA1045 RING finger zf-RING_9 PF13901.4 NM_001316327.1_1 - 0.038 13.8 13.5 0.25 11.1 4.0 2.6 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon APH PF01636.21 NM_001316327.1_1 - 0.16 11.7 0.1 0.3 10.8 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FYVE_2 PF02318.14 NM_001316327.1_1 - 0.37 10.9 9.6 0.64 10.1 1.6 2.7 2 0 0 2 2 2 0 FYVE-type zinc finger Prok-RING_1 PF14446.4 NM_001316327.1_1 - 0.59 10.0 12.6 2.4 8.0 2.9 3.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD PF00628.27 NM_001316327.1_1 - 1.3 8.8 23.3 0.097 12.5 3.1 3.0 3 0 0 3 3 3 0 PHD-finger DUF2318 PF10080.7 NM_001316327.1_1 - 1.4 8.9 14.2 0.66 10.0 4.7 2.4 1 1 0 2 2 2 0 Predicted membrane protein (DUF2318) PADR1 PF08063.10 NM_001316327.1_1 - 7.3 6.3 12.0 0.083 12.5 3.1 2.4 2 0 0 2 2 2 0 PADR1 (NUC008) domain Hyccin PF09790.7 NM_001321628.1_3 - 9.2e-109 363.2 0.0 1.5e-108 362.6 0.0 1.2 1 0 0 1 1 1 1 Hyccin Tetraspannin PF00335.18 NM_001025239.1_1 - 3.7e-44 150.9 12.3 4.6e-44 150.6 12.3 1.1 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.13 NM_001025239.1_1 - 0.00093 19.2 3.4 0.0018 18.3 3.4 1.4 1 0 0 1 1 1 1 CD20-like family DUF2207 PF09972.7 NM_001025239.1_1 - 2.8 6.5 4.5 1.2 7.6 2.5 1.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) TruD PF01142.16 NM_001271826.1_1 - 9.6e-69 232.0 0.0 1.3e-68 231.6 0.0 1.1 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) VWA PF00092.26 NM_003637.4_2 - 8.8e-39 133.4 0.0 1.2e-38 132.9 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_alpha2 PF08441.10 NM_003637.4_2 - 1e-37 130.0 0.0 1.5e-37 129.5 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 NM_003637.4_2 - 9.9e-16 57.4 13.1 2.8e-06 27.2 0.8 4.2 4 0 0 4 4 4 3 FG-GAP repeat VWA_2 PF13519.4 NM_003637.4_2 - 6.2e-10 39.6 0.0 1.2e-09 38.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 NM_003637.4_2 - 7.7e-07 29.5 1.1 0.00013 22.4 0.3 2.9 3 0 0 3 3 3 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 NM_003637.4_2 - 0.0057 16.7 5.9 0.95 9.6 0.0 4.1 4 0 0 4 4 4 1 FG-GAP repeat DUF1669 PF07894.10 NM_030919.2_3 - 6.4e-99 330.8 0.0 9.1e-99 330.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) PLDc_2 PF13091.4 NM_030919.2_3 - 2.8e-09 36.8 0.1 4.6e-09 36.1 0.1 1.4 1 0 0 1 1 1 1 PLD-like domain V-set PF07686.15 NM_001197234.2_3 - 3.9e-13 49.4 0.0 7.1e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001197234.2_3 - 5.5e-07 30.0 0.1 1.5e-05 25.4 0.0 2.7 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 NM_001197234.2_3 - 8e-05 22.6 0.8 0.0011 19.0 0.2 2.7 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 NM_001197234.2_3 - 0.00011 22.4 0.0 0.00077 19.6 0.0 2.3 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_001197234.2_3 - 0.0022 17.9 0.0 0.011 15.6 0.0 2.2 2 1 0 2 2 2 1 Immunoglobulin I-set domain Izumo-Ig PF16706.3 NM_001197234.2_3 - 0.052 13.5 0.0 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain DUF3169 PF11368.6 NM_001197234.2_3 - 0.063 12.7 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DUF106 PF01956.14 NM_001197234.2_3 - 0.13 11.8 0.3 0.24 11.0 0.3 1.4 1 0 0 1 1 1 0 Integral membrane protein DUF106 DUF3213 PF11491.6 NM_001197234.2_3 - 0.14 12.2 2.5 0.27 11.3 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3213) DUF4446 PF14584.4 NM_001197234.2_3 - 0.2 11.5 0.5 0.34 10.7 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Collectrin PF16959.3 NM_001204290.1_1 - 0.029 14.0 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 Renal amino acid transporter IncA PF04156.12 NM_001204290.1_1 - 0.24 11.0 1.2 0.38 10.4 1.2 1.2 1 0 0 1 1 1 0 IncA protein AhpC-TSA PF00578.19 NM_006793.4_1 - 1.6e-36 124.8 0.0 2.4e-36 124.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 NM_006793.4_1 - 4e-15 55.6 0.0 6.2e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.7 NM_006793.4_1 - 4.9e-12 45.4 0.1 1e-11 44.3 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin BPS PF08947.8 NM_001001555.2_2 - 1.6e-28 98.1 0.7 4e-28 96.9 0.7 1.7 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 NM_001001555.2_2 - 2.3e-13 49.9 0.0 4.1e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 NM_001001555.2_2 - 2.3e-10 40.9 0.2 4.9e-10 39.8 0.2 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 NM_001001555.2_2 - 5e-09 36.5 0.9 7.2e-09 36.0 0.1 1.8 2 0 0 2 2 2 1 PH domain 60KD_IMP PF02096.18 NM_173827.3_3 - 1.9e-16 60.3 1.2 3.4e-16 59.5 1.2 1.4 1 0 0 1 1 1 1 60Kd inner membrane protein OTU PF02338.17 NM_001136159.1_3 - 1.9e-16 60.6 0.5 3.7e-16 59.6 0.5 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.7 NM_001136159.1_3 - 0.00023 20.5 0.2 0.037 13.3 0.1 2.2 2 0 0 2 2 2 2 Peptidase C65 Otubain ANF_receptor PF01094.26 NM_001178065.1_1 - 9.4e-109 363.6 0.0 1.2e-108 363.2 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 NM_001178065.1_1 - 9.3e-65 218.5 30.7 1.8e-64 217.6 30.7 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 NM_001178065.1_1 - 2.3e-16 59.3 11.2 2.3e-16 59.3 11.2 2.1 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 NM_001178065.1_1 - 5.3e-11 42.7 0.0 2.8e-10 40.3 0.0 2.0 1 1 0 1 1 1 1 Periplasmic binding protein Ephrin_rec_like PF07699.11 NM_001178065.1_1 - 0.0066 16.1 8.0 0.019 14.6 8.0 1.7 1 0 0 1 1 1 1 Putative ephrin-receptor like CCSAP PF15748.3 NM_001178065.1_1 - 0.29 11.2 7.9 0.47 10.5 7.9 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated TFIIA PF03153.11 NM_001178065.1_1 - 4.2 7.1 12.2 6.2 6.6 12.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1220 PF06758.11 NM_001037675.3_1 - 8.4e-164 532.0 76.0 3.5e-28 97.6 0.9 8.6 8 0 0 8 8 8 7 Repeat of unknown function (DUF1220) GAT PF03127.12 NM_001037675.3_1 - 1.9e-05 24.8 10.2 0.045 13.9 1.5 3.4 2 0 0 2 2 2 2 GAT domain TraH PF06122.9 NM_001037675.3_1 - 0.22 10.7 3.9 5.6 6.0 0.2 2.2 2 0 0 2 2 2 0 Conjugative relaxosome accessory transposon protein FANCI_S3 PF14677.4 NM_001037675.3_1 - 0.9 9.0 22.5 0.61 9.6 1.5 4.6 3 2 2 5 5 5 0 FANCI solenoid 3 Lipocalin PF00061.21 NM_001018049.2_2 - 2.7e-32 111.8 0.0 3.4e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family 7tm_1 PF00001.19 NM_001311313.1_1 - 8.4e-38 130.0 29.3 8.4e-38 130.0 29.3 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) GCR PF02155.13 NM_001020825.1_1 - 2.9e-186 618.8 9.5 3.6e-186 618.5 9.5 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 NM_001020825.1_1 - 7e-30 104.0 5.2 1.2e-29 103.3 3.8 1.8 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_001020825.1_1 - 5.5e-28 97.1 13.0 1.1e-27 96.2 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) TFIIA PF03153.11 NM_001278940.1_1 - 4.2e-67 227.8 75.1 2.8e-51 175.7 27.6 2.1 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit TFIIA PF03153.11 NM_001278940.1_3 - 4e-12 46.7 0.0 5.2e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit EB1 PF03271.15 NM_014268.3_1 - 5.4e-16 58.4 0.8 1.1e-15 57.4 0.8 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.29 NM_014268.3_1 - 3.9e-11 43.0 0.2 6.8e-11 42.2 0.2 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_014268.3_1 - 0.014 15.1 0.1 0.031 14.0 0.1 1.5 1 0 0 1 1 1 0 CAMSAP CH domain ING PF12998.5 NM_014268.3_1 - 0.068 13.6 0.5 0.13 12.7 0.5 1.4 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Peptidase_C54 PF03416.17 NM_001321289.1_1 - 3.2e-72 243.0 1.3 1.3e-53 182.0 0.2 2.1 1 1 1 2 2 2 2 Peptidase family C54 7tm_2 PF00002.22 NM_001294335.1_2 - 6.3e-63 212.2 12.9 8.5e-63 211.8 12.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) TSP_1 PF00090.17 NM_001294335.1_2 - 1.8e-39 133.6 67.6 6.9e-12 45.3 8.4 5.3 4 0 0 4 4 4 4 Thrombospondin type 1 domain GAIN PF16489.3 NM_001294335.1_2 - 1.2e-36 126.0 0.0 1.8e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.19 NM_001294335.1_2 - 1.4e-12 47.9 4.5 5.6e-12 46.0 4.5 2.2 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_1 PF00001.19 NM_001294335.1_2 - 0.00073 18.7 0.7 0.0014 17.8 0.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PWWP PF00855.15 NM_133334.2_3 - 2.8e-21 75.6 0.7 6.1e-21 74.6 0.7 1.6 1 0 0 1 1 1 1 PWWP domain HMG_box PF00505.17 NM_133334.2_3 - 2.3e-09 37.4 0.0 5.1e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_133334.2_3 - 0.00045 20.6 0.0 0.001 19.5 0.0 1.5 1 0 0 1 1 1 1 HMG-box domain SCP2 PF02036.15 NM_001256674.1_3 - 1e-16 61.1 0.1 6.7e-16 58.5 0.0 2.2 2 1 1 3 3 3 1 SCP-2 sterol transfer family Band_7 PF01145.23 NM_001256674.1_3 - 0.00019 21.4 0.0 0.00051 20.0 0.0 1.6 2 0 0 2 2 2 1 SPFH domain / Band 7 family DHQS PF01959.14 NM_001256674.1_3 - 0.22 10.2 0.0 0.3 9.8 0.0 1.1 1 0 0 1 1 1 0 3-dehydroquinate synthase (EC 4.6.1.3) BTB PF00651.29 NM_001123329.1_2 - 3.1e-19 69.1 1.5 6.7e-19 68.0 1.5 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 NM_001123329.1_2 - 2.5e-08 33.9 59.6 0.15 12.8 0.3 9.9 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001123329.1_2 - 5.1e-07 29.7 55.7 0.065 13.6 0.1 9.7 9 0 0 9 9 9 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001123329.1_2 - 0.00029 21.0 40.3 0.00058 20.1 2.8 8.1 8 0 0 8 8 8 3 Zinc-finger double domain zf-C2H2_jaz PF12171.6 NM_001123329.1_2 - 0.036 14.2 0.2 0.036 14.2 0.2 7.5 8 0 0 8 8 8 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 NM_001123329.1_2 - 0.46 10.4 19.8 1.4 8.8 1.9 5.1 3 1 2 5 5 5 0 CpXC protein zf-C2H2_9 PF16293.3 NM_001123329.1_2 - 5.3 6.8 6.9 15 5.4 0.2 3.8 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-met PF12874.5 NM_001123329.1_2 - 5.5 7.4 39.0 0.23 11.8 0.4 7.7 7 1 0 7 7 7 0 Zinc-finger of C2H2 type zf-RING_UBOX PF13445.4 NM_001146684.2_1 - 2e-09 37.2 1.4 2.9e-09 36.7 0.3 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_001146684.2_1 - 3.6e-09 36.6 5.2 3.6e-09 36.6 5.2 1.9 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_001146684.2_1 - 6.4e-09 35.5 7.4 1.5e-08 34.3 4.6 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.23 NM_001146684.2_1 - 4.3e-07 29.6 3.8 4.3e-07 29.6 3.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001146684.2_1 - 1.6e-05 24.5 7.1 6.2e-05 22.6 7.1 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001146684.2_1 - 3.2e-05 23.5 4.0 3.2e-05 23.5 4.0 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_001146684.2_1 - 0.00026 20.7 5.4 0.0064 16.2 5.0 2.6 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 FYVE PF01363.19 NM_001146684.2_1 - 0.00038 20.4 2.8 0.00038 20.4 2.8 1.8 2 0 0 2 2 2 1 FYVE zinc finger zf-RING_11 PF17123.3 NM_001146684.2_1 - 0.0019 17.7 3.9 0.0046 16.5 3.9 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_4 PF15227.4 NM_001146684.2_1 - 0.0024 17.8 5.4 0.0067 16.4 5.4 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-4CXXC_R1 PF10497.7 NM_001146684.2_1 - 0.026 14.6 0.4 0.026 14.6 0.4 2.1 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 FYVE_2 PF02318.14 NM_001146684.2_1 - 0.077 13.1 5.1 0.021 14.9 2.0 1.5 2 0 0 2 2 2 0 FYVE-type zinc finger zf-rbx1 PF12678.5 NM_001146684.2_1 - 0.14 12.3 4.9 0.051 13.7 1.6 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-MIZ PF02891.18 NM_001146684.2_1 - 0.58 9.8 4.2 1.5 8.5 4.2 1.7 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger Ank_3 PF13606.4 NM_005007.3_3 - 7.3e-06 25.8 0.4 0.43 11.2 0.3 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.4 NM_005007.3_3 - 2e-05 24.9 0.7 7.9e-05 23.0 0.6 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_005007.3_3 - 3e-05 24.1 0.9 0.0002 21.5 1.2 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_005007.3_3 - 7.5e-05 23.1 0.0 0.00015 22.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 NM_005007.3_3 - 0.0049 17.1 3.8 2.1 8.8 1.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat PHD20L1_u1 PF16660.3 NM_005007.3_3 - 0.055 14.1 2.1 0.056 14.0 0.2 1.9 2 0 0 2 2 2 0 PHD finger protein 20-like protein 1 RRM_1 PF00076.20 NM_006625.5_2 - 9.6e-19 66.8 0.0 1.7e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 NM_006625.5_2 - 0.00016 21.5 0.0 0.00035 20.3 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-H2C2_2 PF13465.4 NM_001143766.1_1 - 2.9e-07 30.5 24.7 0.00013 22.1 4.0 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001143766.1_1 - 0.00045 20.7 2.3 0.00045 20.7 2.3 5.7 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001143766.1_1 - 0.0016 18.7 2.8 0.0016 18.7 2.8 4.8 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-met PF12874.5 NM_001143766.1_1 - 0.077 13.3 0.1 0.077 13.3 0.1 3.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Pkinase PF00069.23 NM_001323377.1_1 - 1.1e-50 172.3 0.0 1.5e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001323377.1_1 - 4.9e-15 55.4 0.0 7.8e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001323377.1_1 - 0.00078 18.7 0.0 0.0013 18.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001323377.1_1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.23 NM_001323377.1_3 - 4.9e-08 32.5 0.1 6.8e-08 32.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain ABC_membrane PF00664.21 NM_018850.2_2 - 7.8e-152 504.4 23.1 2.8e-91 305.8 10.4 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 NM_018850.2_2 - 1.3e-75 252.3 0.8 7.6e-38 130.0 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 NM_018850.2_2 - 2.6e-17 62.8 3.1 5.4e-07 29.1 0.1 3.9 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.7 NM_018850.2_2 - 2.3e-10 39.7 0.5 0.00016 20.5 0.0 3.0 3 0 0 3 3 3 2 Predicted ATPase of the ABC class Zeta_toxin PF06414.10 NM_018850.2_2 - 1.5e-08 34.1 0.1 0.00025 20.3 0.0 3.2 3 0 0 3 3 3 2 Zeta toxin AAA_22 PF13401.4 NM_018850.2_2 - 3.4e-08 33.7 0.8 0.0076 16.4 0.1 3.3 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.4 NM_018850.2_2 - 3.5e-08 33.9 3.4 0.0038 17.5 0.1 3.3 2 2 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.14 NM_018850.2_2 - 6.6e-08 32.5 0.1 0.013 15.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 G-alpha PF00503.18 NM_018850.2_2 - 3e-07 29.8 0.4 0.0023 17.0 0.1 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA PF00004.27 NM_018850.2_2 - 9.4e-07 29.2 4.3 0.024 14.9 0.1 4.4 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.4 NM_018850.2_2 - 1.1e-06 28.1 0.6 0.027 14.0 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Rad17 PF03215.13 NM_018850.2_2 - 1.8e-06 27.0 0.1 0.0071 15.2 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_15 PF13175.4 NM_018850.2_2 - 4.6e-06 26.4 0.2 0.041 13.4 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.4 NM_018850.2_2 - 2e-05 24.3 2.0 0.12 11.9 0.1 3.3 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.12 NM_018850.2_2 - 2.1e-05 24.4 0.3 0.44 10.4 0.1 3.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) DUF87 PF01935.15 NM_018850.2_2 - 2.9e-05 24.1 0.7 0.35 10.7 0.1 2.9 3 0 0 3 3 3 2 Domain of unknown function DUF87 AAA_14 PF13173.4 NM_018850.2_2 - 3.9e-05 23.6 0.1 0.017 15.0 0.0 3.6 3 1 0 3 3 3 1 AAA domain AAA_21 PF13304.4 NM_018850.2_2 - 0.00015 21.5 0.1 3.3 7.3 0.0 4.2 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.4 NM_018850.2_2 - 0.00016 21.7 4.9 0.41 10.8 0.4 3.9 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.15 NM_018850.2_2 - 0.00022 20.9 0.9 10 5.7 0.0 4.2 4 0 0 4 4 4 0 IstB-like ATP binding protein APS_kinase PF01583.18 NM_018850.2_2 - 0.00026 20.8 0.5 0.77 9.5 0.0 2.8 3 0 0 3 3 2 2 Adenylylsulphate kinase PRK PF00485.16 NM_018850.2_2 - 0.00052 19.7 0.0 1.1 8.9 0.0 2.5 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family DUF815 PF05673.11 NM_018850.2_2 - 0.00068 18.7 0.1 0.25 10.4 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATP-synt_ab PF00006.23 NM_018850.2_2 - 0.001 18.6 0.1 1.8 8.0 0.0 2.5 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.20 NM_018850.2_2 - 0.0011 19.1 0.0 3.9 7.8 0.0 3.3 3 0 0 3 3 2 1 RNA helicase AAA_28 PF13521.4 NM_018850.2_2 - 0.0014 18.7 0.4 4 7.5 0.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.4 NM_018850.2_2 - 0.0015 18.2 0.0 0.5 9.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.4 NM_018850.2_2 - 0.0042 17.1 0.0 2.6 8.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.4 NM_018850.2_2 - 0.0059 17.0 0.0 5.5 7.4 0.0 3.2 3 0 0 3 3 2 0 AAA domain DUF2207 PF09972.7 NM_018850.2_2 - 0.006 15.3 0.1 0.006 15.3 0.1 3.2 4 0 0 4 4 4 1 Predicted membrane protein (DUF2207) tRNA_lig_kinase PF08303.9 NM_018850.2_2 - 0.0072 16.3 0.0 5.6 6.9 0.0 2.6 2 0 0 2 2 2 0 tRNA ligase kinase domain NACHT PF05729.10 NM_018850.2_2 - 0.0097 15.7 0.0 3.7 7.3 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.4 NM_018850.2_2 - 0.036 13.5 1.5 6.5 6.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain ArgK PF03308.14 NM_018850.2_2 - 0.04 12.8 0.0 7.9 5.2 0.0 2.4 2 0 0 2 2 2 0 ArgK protein NB-ARC PF00931.20 NM_018850.2_2 - 0.051 12.5 1.8 5.9 5.7 0.1 2.6 3 0 0 3 3 2 0 NB-ARC domain PduV-EutP PF10662.7 NM_018850.2_2 - 0.085 12.5 0.6 24 4.5 0.0 3.3 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.4 NM_018850.2_2 - 0.094 13.1 0.5 16 5.8 0.1 3.0 3 0 0 3 3 2 0 AAA domain SAM_1 PF00536.28 NM_003626.3_3 - 2.6e-24 85.3 0.2 1e-11 44.9 0.1 3.6 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_003626.3_3 - 2.1e-20 72.5 0.2 7.3e-07 29.1 0.0 3.6 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) HWE_HK PF07536.12 NM_003626.3_3 - 5 7.8 23.3 0.21 12.2 2.2 5.5 3 1 3 6 6 6 0 HWE histidine kinase HAGH_C PF16123.3 NM_015488.4_1 - 1.1e-18 67.4 0.0 1.9e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 NM_015488.4_1 - 5e-11 42.9 1.3 1.9e-10 41.0 1.3 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 NM_015488.4_1 - 0.0013 18.1 0.4 0.0024 17.3 0.4 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain HSR PF03172.11 NM_007237.4_2 - 1.4e-40 137.3 0.1 2.4e-40 136.6 0.1 1.4 1 0 0 1 1 1 1 HSR domain SAND PF01342.19 NM_007237.4_2 - 4e-32 109.6 0.4 7.9e-32 108.7 0.4 1.5 1 0 0 1 1 1 1 SAND domain Bromodomain PF00439.23 NM_007237.4_2 - 2.2e-07 30.7 0.0 5.2e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Bromodomain PHD PF00628.27 NM_007237.4_2 - 1.6e-06 27.8 14.6 1.8e-06 27.6 11.4 2.7 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.4 NM_007237.4_2 - 0.085 12.3 4.3 0.29 10.6 4.3 2.0 1 0 0 1 1 1 0 PHD-finger Tubulin PF00091.23 NM_001293215.1_3 - 1.5e-59 201.4 0.0 2.3e-59 200.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_001293215.1_3 - 8.7e-42 142.2 0.1 1.3e-41 141.6 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 NM_001293215.1_3 - 0.019 14.5 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 NM_001293215.1_3 - 0.043 12.9 0.0 0.075 12.1 0.0 1.3 1 0 0 1 1 1 0 Tubulin like VKOR PF07884.12 NM_206824.2_1 - 7.1e-07 29.3 0.1 1.2e-06 28.6 0.1 1.3 1 0 0 1 1 1 1 Vitamin K epoxide reductase family VKOR PF07884.12 NM_206824.2_2 - 4.3e-08 33.2 6.0 6.3e-08 32.7 6.0 1.2 1 0 0 1 1 1 1 Vitamin K epoxide reductase family zf-H2C2_2 PF13465.4 NM_001323648.1_3 - 9.9e-28 95.2 57.8 1.2e-07 31.7 5.1 8.0 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001323648.1_3 - 2.7e-23 80.9 66.2 0.00019 21.6 5.0 8.2 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001323648.1_3 - 5.1e-13 48.5 62.2 0.053 14.2 4.4 8.1 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001323648.1_3 - 1.6e-07 31.3 47.4 0.019 15.1 1.7 7.8 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 NM_001323648.1_3 - 1.9e-07 31.1 25.9 2.9e-07 30.5 1.4 3.9 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 NM_001323648.1_3 - 1.8e-05 24.8 52.7 0.041 14.2 2.4 7.3 7 0 0 7 7 7 5 Zinc-finger of C2H2 type Homeobox PF00046.27 NM_001323648.1_3 - 3.8e-05 23.3 0.0 9.5e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 Homeobox domain zf-C2H2_6 PF13912.4 NM_001323648.1_3 - 0.0035 17.1 58.8 0.93 9.4 0.8 7.7 7 0 0 7 7 7 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001323648.1_3 - 1.2 9.2 21.4 0.16 12.0 2.9 4.5 4 0 0 4 4 4 0 Zinc ribbon domain zf-C2H2_9 PF16293.3 NM_001323648.1_3 - 4.3 7.1 16.7 7.3 6.4 0.1 4.9 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.5 NM_001323648.1_3 - 5.4 7.3 42.9 0.14 12.3 2.3 6.2 2 2 3 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.3 NM_001323648.1_3 - 7.1 6.4 27.6 0.17 11.5 0.5 5.6 5 0 0 5 5 5 0 zinc-finger C2H2-type FKBP_C PF00254.26 NM_054033.3_3 - 4.4e-29 100.5 0.0 6.1e-29 100.1 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase adh_short_C2 PF13561.4 NM_001193635.1_1 - 2.7e-12 46.6 0.0 3.7e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 NM_001193635.1_2 - 3.8e-26 91.6 1.0 4.9e-19 68.4 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 NM_001193635.1_2 - 4.3e-21 75.4 1.3 5.1e-16 58.8 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_001193635.1_2 - 0.0088 15.8 2.1 0.028 14.2 0.5 2.1 1 1 1 2 2 2 1 KR domain COesterase PF00135.26 NM_001190201.1_1 - 2.8e-132 442.1 0.0 3.4e-132 441.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 NM_001190201.1_1 - 1.8e-05 24.6 1.2 0.00013 21.8 1.2 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_001190201.1_1 - 0.049 13.0 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family DM PF00751.16 NM_001190201.1_3 - 0.12 12.1 2.4 0.38 10.5 2.4 1.9 1 0 0 1 1 1 0 DM DNA binding domain 7tm_1 PF00001.19 NM_001030015.2_3 - 3.6e-51 173.8 16.7 5.4e-51 173.3 16.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.6 NM_001030015.2_3 - 1.3 8.6 11.5 2.5 7.7 11.5 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 7tm_4 PF13853.4 NM_001030015.2_3 - 3.7 7.1 11.5 0.38 10.3 5.4 2.2 2 1 0 2 2 2 0 Olfactory receptor Rad51 PF08423.9 NM_001321818.1_3 - 2.3e-51 174.4 0.0 3.4e-51 173.8 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 NM_001321818.1_3 - 3.5e-10 39.7 0.0 5.1e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.13 NM_001321818.1_3 - 7.8e-08 31.8 0.8 6.6e-07 28.7 0.8 2.0 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.11 NM_001321818.1_3 - 1.3e-07 31.1 0.2 3e-07 29.9 0.2 1.6 1 1 0 1 1 1 1 KaiC RecA PF00154.19 NM_001321818.1_3 - 3.5e-06 26.5 1.1 6.4e-05 22.4 1.1 2.1 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_24 PF13479.4 NM_001321818.1_3 - 0.0015 18.1 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.16 NM_001321818.1_3 - 0.029 14.1 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA PF00004.27 NM_001321818.1_3 - 0.07 13.4 0.2 0.18 12.1 0.2 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.4 NM_001321818.1_3 - 0.097 12.2 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain zf-C2H2 PF00096.24 NM_001178101.1_1 - 0.0024 18.1 2.9 0.0024 18.1 2.9 4.2 4 0 0 4 4 4 1 Zinc finger, C2H2 type HNH PF01844.21 NM_001178101.1_1 - 0.013 15.5 1.8 0.023 14.7 0.6 2.1 1 1 0 1 1 1 0 HNH endonuclease zf-C2H2_6 PF13912.4 NM_001178101.1_1 - 0.014 15.2 5.6 0.51 10.2 1.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger PHD PF00628.27 NM_001178101.1_1 - 0.015 15.0 2.3 0.078 12.7 2.3 2.3 1 0 0 1 1 1 0 PHD-finger zf-C2H2_4 PF13894.4 NM_001178101.1_1 - 0.25 12.1 10.5 0.13 13.0 1.6 4.0 2 0 0 2 2 2 0 C2H2-type zinc finger GETHR PF05671.9 NM_001178101.1_1 - 5.2 6.4 12.4 43 3.5 0.1 5.5 6 0 0 6 6 6 0 GETHR pentapeptide repeat (5 copies) zf-H2C2_2 PF13465.4 NM_001178101.1_2 - 1.1e-65 215.2 91.1 4.5e-08 33.0 0.2 13.5 14 0 0 14 14 14 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001178101.1_2 - 3.7e-47 156.1 98.5 3.7e-06 27.0 1.3 13.4 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001178101.1_2 - 3.7e-26 89.4 82.3 0.00083 19.9 1.0 12.7 11 0 0 11 11 11 10 C2H2-type zinc finger KRAB PF01352.25 NM_001178101.1_2 - 4.4e-25 87.0 0.1 8.3e-25 86.1 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001178101.1_2 - 9e-11 41.3 70.4 0.015 15.1 0.8 11.5 11 0 0 11 11 11 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001178101.1_2 - 3.4e-07 30.1 46.0 0.021 14.8 2.1 7.1 6 0 0 6 6 6 5 Zinc ribbon domain C1_4 PF07975.10 NM_001178101.1_2 - 0.003 17.7 45.9 0.59 10.3 3.0 6.8 3 3 2 5 5 5 3 TFIIH C1-like domain zf-C2H2_jaz PF12171.6 NM_001178101.1_2 - 0.017 15.3 56.1 0.27 11.4 0.4 10.4 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding DUF3506 PF12014.6 NM_001178101.1_2 - 0.16 11.8 0.3 2.3 8.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) zinc_ribbon_15 PF17032.3 NM_001178101.1_2 - 0.26 11.9 39.1 0.53 10.9 1.5 6.0 1 1 6 7 7 7 0 zinc-ribbon family LIM PF00412.20 NM_001080114.1_3 - 1.6e-36 124.2 31.9 6.4e-14 51.8 4.8 3.6 3 0 0 3 3 3 3 LIM domain DUF4749 PF15936.3 NM_001080114.1_3 - 1.5e-24 86.8 0.2 3.1e-24 85.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.22 NM_001080114.1_3 - 1.7e-15 57.0 0.0 3e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001080114.1_3 - 0.00034 20.8 0.0 0.00066 19.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain TEX13 PF15186.4 NM_031274.4_3 - 1.1e-67 226.3 3.1 1.7e-67 225.6 3.1 1.2 1 0 0 1 1 1 1 Testis-expressed sequence 13 protein family zf-RanBP PF00641.16 NM_031274.4_3 - 5.7e-06 25.4 4.6 1e-05 24.6 4.6 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others HTH_37 PF13744.4 NM_031274.4_3 - 0.25 11.2 1.9 0.45 10.3 1.9 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Miff PF05644.9 NM_001277067.1_2 - 6.1e-108 360.8 5.0 1e-107 360.0 5.0 1.3 1 1 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff RasGEF PF00617.17 NM_001139488.1_1 - 5.1e-45 153.6 0.7 7.6e-45 153.0 0.7 1.3 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 NM_001139488.1_1 - 1.7e-12 46.9 9.3 1.7e-12 46.9 9.3 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.30 NM_001139488.1_1 - 3.1e-09 35.6 2.5 0.00062 19.0 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 NM_001139488.1_1 - 3.2e-08 33.8 1.5 1.2e-05 25.5 1.5 3.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_001139488.1_1 - 7.2e-08 31.6 3.7 0.00041 19.9 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 NM_001139488.1_1 - 3.1e-07 29.5 0.4 0.034 13.5 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 NM_001139488.1_1 - 0.00035 20.1 1.4 0.26 10.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair RasGEF_N PF00618.18 NM_001139488.1_1 - 0.00049 20.2 0.1 0.0016 18.6 0.1 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif Lactamase_B PF00753.25 NM_001320868.1_3 - 7.1e-07 29.3 0.1 9.6e-07 28.9 0.1 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily GAT PF03127.12 NM_001288789.1_2 - 9.9e-27 92.9 2.5 1.6e-26 92.3 2.5 1.3 1 0 0 1 1 1 1 GAT domain VHS PF00790.17 NM_001288789.1_2 - 2.1e-17 63.2 0.0 3.9e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 VHS domain DUF59 PF01883.17 NM_016062.3_3 - 6.2e-16 58.2 0.1 1.1e-15 57.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF59 MDFI PF15316.4 NM_005586.3_1 - 2.2e-53 181.1 41.7 3.6e-53 180.4 41.7 1.3 1 0 0 1 1 1 1 MyoD family inhibitor RhoGAP PF00620.25 NM_032900.5_2 - 2.1e-35 121.7 0.4 4.3e-35 120.6 0.4 1.5 1 0 0 1 1 1 1 RhoGAP domain RAMP PF04901.11 NM_001308353.1_2 - 4.3e-44 148.9 0.0 5.7e-44 148.5 0.0 1.2 1 0 0 1 1 1 1 Receptor activity modifying family zf-C2H2 PF00096.24 NM_001318042.1_1 - 1.7e-05 24.9 28.3 0.45 11.0 2.9 5.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type Dimer_Tnp_hAT PF05699.12 NM_001318042.1_1 - 0.0079 15.8 0.1 0.0079 15.8 0.1 2.1 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region zf-C2H2_4 PF13894.4 NM_001318042.1_1 - 0.039 14.6 42.8 0.087 13.6 2.3 6.9 6 0 0 6 6 6 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_001318042.1_1 - 0.062 13.6 14.8 4.7 7.7 0.1 5.6 4 0 0 4 4 4 0 Zinc-finger double domain DUF423 PF04241.13 NM_152766.3_3 - 4.9e-17 61.8 0.7 7.9e-17 61.1 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) DUF2648 PF10855.6 NM_152766.3_3 - 0.12 12.2 0.6 0.41 10.5 0.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2648) Ig_2 PF13895.4 NM_198481.3_3 - 4.1e-08 33.3 0.2 7.2e-08 32.5 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_198481.3_3 - 3.3e-07 30.7 0.0 8.7e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 NM_198481.3_3 - 0.00015 21.7 0.3 0.00015 21.7 0.3 1.9 2 0 0 2 2 2 1 Immunoglobulin domain DUF4962 PF16332.3 NM_198481.3_3 - 0.00096 17.6 0.4 0.0014 17.1 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4962) V-set PF07686.15 NM_198481.3_3 - 0.0022 18.0 0.5 0.063 13.3 0.0 2.6 2 1 1 3 3 3 1 Immunoglobulin V-set domain DUF3328 PF11807.6 NM_198481.3_3 - 0.018 14.7 0.5 0.039 13.6 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) SID-1_RNA_chan PF13965.4 NM_198481.3_3 - 0.12 10.7 0.4 0.14 10.4 0.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF912 PF06024.10 NM_198481.3_3 - 0.14 12.4 0.0 0.33 11.1 0.0 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) zf-CCCH PF00642.22 NM_144778.3_1 - 2.5e-09 36.7 19.2 0.00087 19.0 0.7 4.7 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 NM_144778.3_1 - 0.0039 17.5 24.7 1.2 9.6 1.4 5.0 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.3 NM_144778.3_1 - 0.0087 16.2 21.5 0.011 15.9 0.6 3.8 4 0 0 4 4 4 2 Zinc-finger containing family Torus PF16131.3 NM_144778.3_1 - 0.085 13.4 18.6 1.7 9.2 0.3 4.2 2 2 2 4 4 4 0 Torus domain DUF814 PF05670.11 NM_018246.2_3 - 5.5e-26 90.3 0.3 8.6e-26 89.7 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF814) APOBEC_N PF08210.9 NM_006789.3_1 - 9.7e-51 172.1 0.2 1.3e-50 171.7 0.2 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 NM_006789.3_1 - 7.4e-26 89.8 0.4 7.4e-26 89.8 0.4 1.7 2 0 0 2 2 2 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 NM_006789.3_1 - 0.01 15.5 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 NM_006789.3_1 - 0.031 13.9 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 MafB19-like deaminase CHCH PF06747.11 NM_014222.2_2 - 1.1e-09 38.0 2.8 1.1e-09 38.0 2.8 2.4 2 0 0 2 2 2 1 CHCH domain CX9C PF16860.3 NM_014222.2_2 - 0.0025 17.7 2.5 0.0025 17.7 2.5 2.6 2 1 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.8 NM_014222.2_2 - 0.032 14.1 1.1 0.032 14.1 1.1 2.4 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like Cdd1 PF11731.6 NM_014222.2_2 - 0.13 12.3 2.3 8.1 6.6 0.2 2.3 1 1 1 2 2 2 0 Pathogenicity locus Myb_DNA-bind_5 PF13873.4 NM_032424.2_1 - 9.3e-23 80.0 6.0 2.2e-22 78.8 6.0 1.7 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain R3H PF01424.20 NM_001136108.2_1 - 2.6e-16 59.2 0.2 6.7e-16 57.9 0.1 1.8 2 0 0 2 2 2 1 R3H domain NCBP3 PF10309.7 NM_001136108.2_1 - 7e-05 22.5 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 DUF4749 PF15936.3 NM_001114107.4_2 - 1.2e-23 83.9 0.0 2.1e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.22 NM_001114107.4_2 - 1.6e-15 57.1 0.0 2.7e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LIM PF00412.20 NM_001114107.4_2 - 1.2e-12 47.7 3.1 1.2e-12 47.7 3.1 2.0 2 0 0 2 2 2 1 LIM domain PDZ_2 PF13180.4 NM_001114107.4_2 - 0.0034 17.5 0.0 0.0065 16.6 0.0 1.3 1 0 0 1 1 1 1 PDZ domain DUF4505 PF14956.4 NM_001001795.1_3 - 6e-79 263.8 0.0 7.7e-79 263.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4505) YTH PF04146.13 NM_001173128.1_3 - 4e-40 136.2 0.0 6.7e-40 135.4 0.0 1.4 1 0 0 1 1 1 1 YT521-B-like domain TFIIA PF03153.11 NM_001173128.1_3 - 1.1 9.0 8.3 2.2 8.0 8.3 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Got1 PF04178.10 NM_198447.1_1 - 1.1e-14 54.6 15.8 1.5e-14 54.2 15.8 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family MBOAT PF03062.17 NM_001170588.2_3 - 3.6e-61 207.3 28.4 5.1e-61 206.8 28.4 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Ank_2 PF12796.5 NM_001300975.1_3 - 4.4e-54 180.9 7.5 8.1e-16 58.3 0.1 4.7 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001300975.1_3 - 6.3e-43 144.5 18.1 3.2e-10 40.2 0.4 6.0 3 1 4 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001300975.1_3 - 5.9e-31 105.9 5.9 2.1e-08 34.1 0.0 5.9 2 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 NM_001300975.1_3 - 6.8e-29 98.9 10.4 2.3e-06 27.7 0.1 7.8 9 0 0 9 9 9 5 Ankyrin repeat Ank_3 PF13606.4 NM_001300975.1_3 - 5.2e-24 81.6 4.9 0.00064 19.9 0.0 8.1 8 0 0 8 8 8 4 Ankyrin repeat HalX PF08663.8 NM_001300975.1_3 - 0.0096 16.0 6.8 0.02 15.0 6.8 1.5 1 0 0 1 1 1 1 HalX domain DUF641 PF04859.10 NM_001300975.1_3 - 0.03 14.5 4.0 0.06 13.6 4.0 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) HIP1_clath_bdg PF16515.3 NM_001300975.1_3 - 0.72 10.4 6.0 1.8 9.1 6.0 1.6 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AAA_23 PF13476.4 NM_001300975.1_3 - 3.4 8.0 8.2 6.1 7.2 8.2 1.4 1 0 0 1 1 1 0 AAA domain cNMP_binding PF00027.27 NM_212471.2_1 - 1.4e-40 137.0 0.1 1.1e-19 70.1 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 NM_212471.2_1 - 2.6e-15 55.7 0.2 4.5e-15 54.9 0.2 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Ribosomal_L16 PF00252.16 NM_001256580.2_3 - 7e-30 103.6 4.5 1.3e-29 102.7 1.1 2.1 1 1 1 2 2 2 2 Ribosomal protein L16p/L10e 7tm_4 PF13853.4 NM_014565.2_1 - 2e-55 188.4 15.1 2.3e-55 188.1 15.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_014565.2_1 - 9.5e-25 87.2 17.3 4.1e-24 85.1 17.3 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_014565.2_1 - 8.7e-06 25.2 14.7 1.4e-05 24.5 14.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_014565.2_1 - 0.0034 16.6 14.6 0.018 14.2 14.6 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Histone_H2A_C PF16211.3 NM_021064.4_2 - 1.9e-20 72.2 2.4 3.1e-20 71.5 2.4 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 NM_021064.4_2 - 1.8e-16 60.6 0.0 2.5e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_021064.4_2 - 5.4e-05 23.3 0.0 7.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SMC_N PF02463.17 NM_001042550.1_3 - 2.3e-62 210.2 21.6 7.5e-37 126.8 1.7 2.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 NM_001042550.1_3 - 1.1e-22 80.5 0.2 1.1e-22 80.5 0.2 1.9 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.4 NM_001042550.1_3 - 1e-09 38.5 10.7 4.5e-05 23.3 0.8 3.0 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.4 NM_001042550.1_3 - 1e-05 25.2 33.6 1e-05 25.2 33.6 4.5 2 2 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.4 NM_001042550.1_3 - 0.0011 18.5 0.0 0.0026 17.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.25 NM_001042550.1_3 - 0.019 15.3 0.1 0.019 15.3 0.1 6.4 4 2 0 4 4 4 0 ABC transporter P2X_receptor PF00864.17 NM_001204520.1_1 - 1e-119 399.8 11.0 1.4e-86 290.8 0.2 3.1 1 1 2 3 3 3 3 ATP P2X receptor EF-hand_1 PF00036.30 NM_012392.3_2 - 4.8e-16 56.9 0.0 1.5e-05 24.1 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_012392.3_2 - 1.1e-15 56.0 0.0 3e-06 26.6 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.4 NM_012392.3_2 - 2.5e-15 56.5 0.0 1.1e-06 28.9 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_012392.3_2 - 1.6e-13 49.4 0.0 0.00015 21.0 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 NM_012392.3_2 - 6.9e-08 32.0 0.0 0.00093 18.8 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.4 NM_012392.3_2 - 0.047 13.9 0.0 3 8.1 0.0 2.6 2 1 0 2 2 2 0 EF-hand domain Methyltransf_3 PF01596.15 NM_000754.3_1 - 1.4e-18 66.7 0.0 2.9e-18 65.7 0.0 1.4 2 0 0 2 2 2 1 O-methyltransferase Methyltransf_24 PF13578.4 NM_000754.3_1 - 4.8e-11 43.5 0.0 7.7e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.8 NM_000754.3_1 - 0.005 16.5 0.0 0.0075 15.9 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase CmcI PF04989.10 NM_000754.3_1 - 0.0094 15.5 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase PCMT PF01135.17 NM_000754.3_1 - 0.04 13.5 0.0 0.062 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.4 NM_000754.3_1 - 0.14 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_M13_N PF05649.11 NM_001113348.1_2 - 1.3e-125 420.0 0.3 1.6e-125 419.6 0.3 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.19 NM_001113348.1_2 - 4.3e-74 248.4 0.0 8.4e-74 247.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M13 IATP PF04568.10 NM_178190.2_1 - 1.2e-07 31.9 0.3 1.6e-07 31.5 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Cep57_MT_bd PF06657.11 NM_178190.2_2 - 0.0086 16.4 3.0 0.015 15.6 3.0 1.4 1 0 0 1 1 1 1 Centrosome microtubule-binding domain of Cep57 DUF812 PF05667.9 NM_178190.2_2 - 0.0094 14.8 0.0 0.0094 14.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Phage_lysis PF03245.11 NM_178190.2_2 - 0.028 14.4 0.4 0.05 13.6 0.4 1.4 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein DivIC PF04977.13 NM_178190.2_2 - 0.084 12.5 4.5 0.16 11.6 4.5 1.5 1 0 0 1 1 1 0 Septum formation initiator DUF1192 PF06698.9 NM_178190.2_2 - 0.21 11.5 3.1 0.47 10.4 3.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) CENP-H PF05837.10 NM_178190.2_2 - 0.41 10.9 5.2 0.71 10.2 5.2 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) IATP PF04568.10 NM_178190.2_2 - 3.3 8.0 9.8 0.69 10.2 6.2 1.7 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP TraB PF01963.15 NM_001194986.1_3 - 1.8e-63 214.8 0.0 2.3e-63 214.4 0.0 1.1 1 0 0 1 1 1 1 TraB family SNARE PF05739.17 NM_003164.4_2 - 4.7e-16 58.4 0.6 9.1e-16 57.5 0.6 1.5 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.6 NM_003164.4_2 - 2.8e-11 42.2 1.2 7.4e-11 40.8 1.2 1.8 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.23 NM_003164.4_2 - 0.00067 19.3 16.1 0.0095 15.5 1.7 2.6 2 1 1 3 3 3 2 Syntaxin DUF16 PF01519.14 NM_003164.4_2 - 0.028 14.8 9.4 0.092 13.1 2.3 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 SKA1 PF07160.10 NM_003164.4_2 - 0.12 12.0 9.5 0.83 9.3 1.5 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Vac_Fusion PF02346.14 NM_003164.4_2 - 0.15 11.6 0.4 0.52 9.8 0.1 2.1 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 DUF5063 PF16702.3 NM_003164.4_2 - 0.41 10.9 2.3 0.68 10.2 0.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5063) DUF1664 PF07889.10 NM_003164.4_2 - 0.88 9.4 9.9 0.74 9.7 1.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.7 NM_003164.4_2 - 1.7 8.9 9.3 0.83 9.9 2.1 2.9 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 COG5 PF10392.7 NM_003164.4_2 - 2.9 7.9 9.2 0.42 10.6 0.5 2.6 2 1 1 3 3 3 0 Golgi transport complex subunit 5 Noelin-1 PF12308.6 NM_003164.4_2 - 3.1 7.7 5.1 9.3 6.2 0.3 2.7 2 0 0 2 2 2 0 Neurogenesis glycoprotein Fib_alpha PF08702.8 NM_003164.4_2 - 3.4 7.7 15.0 0.52 10.3 2.7 2.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Troponin PF00992.18 NM_003164.4_2 - 4 7.6 7.1 4.1 7.6 0.2 2.7 2 1 1 3 3 3 0 Troponin Spectrin PF00435.19 NM_003164.4_2 - 5.1 7.5 8.1 2.1 8.7 0.6 3.0 2 1 1 3 3 3 0 Spectrin repeat Mon1 PF03164.12 NM_032355.3_1 - 1.6e-140 468.6 0.0 1.9e-140 468.4 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 MMR_HSR1 PF01926.21 NM_001184819.1_2 - 4.1e-14 52.5 0.0 2.3e-12 46.9 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.16 NM_001184819.1_2 - 1e-07 31.5 0.2 5e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.14 NM_001184819.1_2 - 0.00063 19.6 0.2 0.9 9.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_001184819.1_2 - 0.0064 15.9 0.2 0.055 12.9 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Pkinase PF00069.23 NM_001128628.2_3 - 1.7e-66 224.2 0.0 2.2e-66 223.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001128628.2_3 - 8.6e-45 152.9 0.0 1.2e-44 152.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 NM_001128628.2_3 - 1.1e-15 57.6 0.1 2.4e-15 56.5 0.1 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 NM_001128628.2_3 - 3.5e-07 29.7 0.0 5.4e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001128628.2_3 - 0.097 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PMP22_Claudin PF00822.18 NM_022121.4_1 - 4.7e-09 36.2 8.4 7.8e-09 35.5 8.4 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family ABC2_membrane_3 PF12698.5 NM_019112.3_1 - 7.5e-62 209.3 21.5 2.4e-44 151.7 5.3 3.0 3 0 0 3 3 3 2 ABC-2 family transporter protein ABC_tran PF00005.25 NM_019112.3_1 - 7.9e-46 155.8 0.0 6.8e-25 88.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 NM_019112.3_1 - 5.3e-22 78.9 0.6 5e-07 29.7 0.0 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 NM_019112.3_1 - 0.0014 19.0 3.0 0.014 15.8 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.4 NM_019112.3_1 - 0.0025 17.4 0.0 0.85 9.0 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain DUF4162 PF13732.4 NM_019112.3_1 - 0.0092 16.6 0.0 2.2 9.0 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) SRP54 PF00448.20 NM_019112.3_1 - 0.02 14.4 0.3 0.67 9.4 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_29 PF13555.4 NM_019112.3_1 - 0.035 13.7 1.3 0.22 11.1 0.3 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain FKBP_C PF00254.26 NM_001322963.1_2 - 5.5e-26 90.6 0.0 8.1e-26 90.0 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Npa1 PF11707.6 NM_014825.2_1 - 8e-84 281.7 2.8 1e-83 281.3 0.9 2.1 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.3 NM_014825.2_1 - 3.7e-53 179.9 1.0 3.7e-53 179.9 1.0 3.1 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 LRIF1 PF15741.3 NM_018372.3_2 - 0 1121.7 48.2 0 1121.5 48.2 1.0 1 0 0 1 1 1 1 Ligand-dependent nuclear receptor-interacting factor 1 PKcGMP_CC PF16808.3 NM_018372.3_2 - 0.7 9.7 6.5 1.3 8.8 6.5 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SLC12 PF03522.13 NM_000338.2_1 - 5.3e-151 503.2 0.1 7.3e-151 502.7 0.1 1.2 1 0 0 1 1 1 1 Solute carrier family 12 AA_permease PF00324.19 NM_000338.2_1 - 6.7e-151 503.0 36.5 8.6e-151 502.6 36.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_N PF08403.8 NM_000338.2_1 - 6.8e-34 115.1 0.0 2.1e-32 110.3 0.1 2.5 2 0 0 2 2 2 1 Amino acid permease N-terminal AA_permease_2 PF13520.4 NM_000338.2_1 - 5.7e-21 74.7 42.9 9.9e-21 73.9 42.9 1.3 1 0 0 1 1 1 1 Amino acid permease Lipocalin PF00061.21 NM_001320996.1_2 - 9.5e-23 80.9 2.2 9.3e-22 77.6 2.2 2.0 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 NM_001320996.1_2 - 6.9e-05 22.7 0.2 0.00013 21.8 0.2 1.4 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family cobW PF02492.17 NM_001024916.3_3 - 2.7e-36 124.7 0.1 3.9e-36 124.1 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.12 NM_001024916.3_3 - 7.7e-18 64.1 0.0 1.4e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain DUF258 PF03193.14 NM_001024916.3_3 - 0.012 15.4 0.1 0.021 14.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_23 PF13476.4 NM_001024916.3_3 - 0.022 15.2 1.8 0.023 15.1 0.0 1.9 2 1 0 2 2 2 0 AAA domain ABC_ATPase PF09818.7 NM_001024916.3_3 - 0.022 13.4 0.0 0.039 12.6 0.0 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class ABC_tran PF00005.25 NM_001024916.3_3 - 0.049 14.0 0.4 0.14 12.6 0.0 1.8 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.4 NM_001024916.3_3 - 0.051 13.8 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.15 NM_001024916.3_3 - 0.06 13.2 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.4 NM_001024916.3_3 - 0.074 13.2 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.10 NM_001024916.3_3 - 0.1 11.8 0.1 0.23 10.6 0.0 1.5 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.4 NM_001024916.3_3 - 0.12 11.9 0.1 0.25 11.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.21 NM_001024916.3_3 - 0.13 12.2 0.1 0.38 10.7 0.1 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase T2SSE PF00437.18 NM_001024916.3_3 - 0.13 11.1 0.2 0.22 10.4 0.2 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein RDM PF11002.6 NM_006605.3_2 - 5.8e-21 74.0 5.1 9.5e-21 73.4 5.1 1.4 1 0 0 1 1 1 1 RFPL defining motif (RDM) zf-C3HC4_4 PF15227.4 NM_006605.3_2 - 3.6e-16 58.9 15.6 7.4e-16 57.9 15.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 NM_006605.3_2 - 6.8e-16 58.3 0.0 1.1e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_006605.3_2 - 1.8e-15 56.1 0.1 3.1e-15 55.4 0.1 1.4 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_2 PF13923.4 NM_006605.3_2 - 0.0017 18.0 4.6 0.0017 18.0 4.6 2.9 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_006605.3_2 - 0.74 9.6 11.8 2.2 8.1 11.8 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_006605.3_2 - 1.6 8.6 18.3 0.074 12.8 12.4 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_006605.3_2 - 2.8 7.9 19.0 0.37 10.7 13.7 2.3 2 0 0 2 2 2 0 RING-type zinc-finger Ferric_reduct PF01794.17 NM_013955.2_3 - 4e-25 88.2 7.0 4e-25 88.2 7.0 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.10 NM_013955.2_3 - 1e-21 76.9 0.0 1.8e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.10 NM_013955.2_3 - 1.2e-18 67.6 0.2 2e-11 44.1 0.1 2.4 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_6 PF00970.22 NM_013955.2_3 - 0.0093 16.2 0.0 0.017 15.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain TRAPP PF04051.14 NM_001270895.1_1 - 6.9e-36 123.0 0.0 9.2e-36 122.6 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component WD40 PF00400.30 NM_001267783.1_3 - 4.1e-06 27.3 7.2 0.00029 21.4 1.0 4.7 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001267783.1_3 - 1e-05 25.6 0.0 0.041 14.1 0.0 3.9 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_001267783.1_3 - 0.041 13.6 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Spt20 PF12090.6 NM_001267783.1_3 - 0.07 12.6 0.9 0.21 11.0 0.6 1.9 2 0 0 2 2 2 0 Spt20 family Guanylate_cyc PF00211.18 NM_021116.2_1 - 4.5e-127 420.7 0.4 2.7e-64 216.0 0.1 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.3 NM_021116.2_1 - 7.8e-28 97.6 0.1 7.8e-28 97.6 0.1 2.3 2 1 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.12 NM_021116.2_1 - 0.068 13.6 0.4 0.11 12.9 0.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) HNOBA PF07701.12 NM_021116.2_1 - 0.29 10.4 0.8 1.8 7.9 0.2 2.4 3 0 0 3 3 3 0 Heme NO binding associated HDAC4_Gln PF12203.6 NM_001204147.2_3 - 1.4e-31 108.4 43.7 1.4e-31 108.4 43.7 3.6 4 0 0 4 4 4 1 Glutamine rich N terminal domain of histone deacetylase 4 zf-H2C2_2 PF13465.4 NM_001256525.1_1 - 1.9e-78 255.5 86.3 4.4e-08 33.1 0.2 13.7 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001256525.1_1 - 7.4e-44 145.7 106.6 2.6e-05 24.3 0.3 12.7 12 0 0 12 12 12 12 Zinc finger, C2H2 type KRAB PF01352.25 NM_001256525.1_1 - 1.9e-24 84.9 0.2 3.5e-24 84.1 0.2 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001256525.1_1 - 3.9e-20 70.7 112.1 0.043 14.5 1.0 13.1 13 0 0 13 13 13 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001256525.1_1 - 7.9e-06 25.8 59.5 0.1 12.6 1.5 8.9 3 2 9 12 12 12 8 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001256525.1_1 - 0.0049 16.5 79.1 0.11 12.2 0.2 11.8 12 0 0 12 12 12 7 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 NM_001256525.1_1 - 0.042 13.7 0.1 0.042 13.7 0.1 12.5 12 1 0 12 12 12 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 NM_001256525.1_1 - 5.6 7.7 46.4 6.9 7.4 2.0 6.7 1 1 4 6 6 6 0 zinc-ribbon family Fer2_BFD PF04324.13 NM_053052.3_2 - 0.13 12.5 1.2 0.76 10.0 0.2 2.5 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain Lyase_1 PF00206.18 NM_001024944.1_2 - 1e-106 356.7 0.0 1.3e-106 356.4 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.4 NM_001024944.1_2 - 3.3e-21 75.7 0.0 2.3e-20 73.0 0.0 2.2 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal Dus PF01207.15 NM_001271763.1_3 - 1.7e-34 119.2 0.1 5.9e-31 107.6 0.0 2.2 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) dsrm PF00035.24 NM_001271763.1_3 - 8.3e-07 29.5 0.0 1.9e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif His_biosynth PF00977.19 NM_001271763.1_3 - 0.02 14.2 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Histidine biosynthesis protein RasGEF PF00617.17 NM_015376.2_3 - 4.5e-45 153.8 0.7 6.6e-45 153.2 0.7 1.3 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 NM_015376.2_3 - 1.5e-12 47.1 9.3 1.5e-12 47.1 9.3 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.30 NM_015376.2_3 - 2.3e-09 36.0 2.5 0.00055 19.2 0.1 3.0 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_015376.2_3 - 5.4e-08 32.0 3.7 0.00037 20.1 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 NM_015376.2_3 - 5.9e-08 32.9 2.8 1e-05 25.7 1.5 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_015376.2_3 - 2.4e-07 29.8 0.4 0.031 13.7 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 NM_015376.2_3 - 0.00028 20.5 1.4 0.24 11.1 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair RasGEF_N PF00618.18 NM_015376.2_3 - 0.00042 20.4 0.1 0.0014 18.7 0.1 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif zf-H2C2_2 PF13465.4 NM_001172668.1_3 - 9.2e-84 272.3 115.5 7.7e-08 32.3 0.4 18.3 18 0 0 18 18 18 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001172668.1_3 - 3.4e-70 228.7 108.6 5e-05 23.4 0.4 16.4 16 0 0 16 16 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001172668.1_3 - 4.5e-53 173.1 105.9 9e-05 22.9 0.8 16.4 16 0 0 16 16 16 16 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001172668.1_3 - 3.5e-24 84.4 43.3 0.0043 17.2 0.0 14.8 16 0 0 16 16 15 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001172668.1_3 - 2.3e-20 71.9 89.7 0.0029 17.4 0.5 16.1 16 0 0 16 16 16 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001172668.1_3 - 1e-05 25.4 74.7 0.02 14.9 2.0 12.2 6 3 6 13 13 13 6 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001172668.1_3 - 0.00017 21.1 73.7 0.021 14.4 0.1 13.3 15 0 0 15 15 15 6 zinc-finger C2H2-type zf-met PF12874.5 NM_001172668.1_3 - 0.0038 17.4 79.1 0.24 11.7 0.4 14.0 15 0 0 15 15 14 4 Zinc-finger of C2H2 type BDHCT_assoc PF16204.3 NM_001172668.1_3 - 0.0081 15.7 2.7 7.2 6.1 0.1 3.2 3 0 0 3 3 3 1 BDHCT-box associated domain on Bloom syndrome protein zf-LYAR PF08790.9 NM_001172668.1_3 - 0.014 15.2 43.3 1.8 8.4 0.1 11.9 14 0 0 14 14 14 0 LYAR-type C2HC zinc finger zf-C2HC_2 PF13913.4 NM_001172668.1_3 - 0.017 14.9 1.1 0.017 14.9 1.1 12.6 14 0 0 14 14 13 0 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.3 NM_001172668.1_3 - 0.018 15.6 41.8 0.58 10.8 0.2 8.1 6 3 3 9 9 9 0 zinc-ribbon family zf-AN1 PF01428.14 NM_001172668.1_3 - 0.033 14.2 67.5 4.4 7.4 0.3 15.1 15 1 0 16 16 16 0 AN1-like Zinc finger C1_4 PF07975.10 NM_001172668.1_3 - 0.063 13.4 50.3 0.48 10.6 0.1 10.3 4 1 10 14 14 14 0 TFIIH C1-like domain DUF3268 PF11672.6 NM_001172668.1_3 - 0.12 12.6 23.0 2.6 8.3 0.1 6.9 7 0 0 7 7 7 0 zinc-finger-containing domain HypA PF01155.17 NM_001172668.1_3 - 2.1 8.3 48.3 6.3 6.7 3.4 8.5 2 2 5 7 7 7 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.12 NM_001172668.1_3 - 9.9 6.2 37.7 1.4 8.8 1.0 8.9 7 3 2 9 9 9 0 Adenylate kinase, active site lid Kelch_1 PF01344.23 NM_001171654.1_3 - 7.4e-84 275.0 14.0 1.9e-17 62.4 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 NM_001171654.1_3 - 4.6e-48 159.9 4.4 4.5e-10 39.3 0.0 6.5 2 2 4 6 6 6 6 Kelch motif BACK PF07707.13 NM_001171654.1_3 - 3.3e-32 110.5 0.1 1.1e-31 108.9 0.1 1.9 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_2 PF07646.13 NM_001171654.1_3 - 8e-32 107.9 9.0 7.5e-07 28.8 0.0 7.1 7 0 0 7 7 7 5 Kelch motif BTB PF00651.29 NM_001171654.1_3 - 4.7e-28 97.5 0.2 7.7e-28 96.8 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.4 NM_001171654.1_3 - 6.8e-28 96.2 9.4 8.2e-07 28.8 0.0 6.4 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.4 NM_001171654.1_3 - 1.1e-18 66.8 11.2 4.5e-07 29.9 0.1 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_001171654.1_3 - 1.7e-06 27.7 2.9 0.34 10.8 0.0 5.2 6 0 0 6 6 6 2 Kelch motif Glu_cyclase_2 PF05096.10 NM_001171654.1_3 - 0.06 12.6 0.0 2.4 7.4 0.0 2.4 1 1 0 2 2 2 0 Glutamine cyclotransferase zf-RanBP PF00641.16 NM_013986.3_2 - 7.6e-13 47.4 7.4 1.4e-12 46.5 7.4 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.20 NM_013986.3_2 - 3.7e-10 39.4 0.0 1.3e-09 37.6 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATF7IP_BD PF16788.3 NM_018179.4_3 - 2.2e-63 214.3 8.7 2.2e-63 214.3 8.7 2.4 3 0 0 3 3 3 1 ATF-interacting protein binding domain fn3_4 PF16794.3 NM_018179.4_3 - 2e-39 133.5 0.0 3.6e-39 132.7 0.0 1.4 1 0 0 1 1 1 1 Fibronectin-III type domain NICE-3 PF07406.9 NM_001297717.1_1 - 1.6e-53 181.2 0.0 3.9e-40 137.6 0.0 2.1 1 1 1 2 2 2 2 NICE-3 protein PDZ PF00595.22 NM_001007070.1_1 - 6.5e-20 71.1 2.9 1.8e-12 47.3 0.1 2.3 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001007070.1_1 - 6.9e-11 42.2 0.2 2e-06 27.9 0.0 2.3 1 1 1 2 2 2 2 PDZ domain Shugoshin_N PF07558.9 NM_001012412.4_3 - 1.7e-11 43.6 2.2 3.5e-11 42.7 2.2 1.5 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.9 NM_001012412.4_3 - 2.9e-10 39.6 1.3 8.8e-10 38.1 1.3 1.9 1 0 0 1 1 1 1 Shugoshin C terminus UQ_con PF00179.24 NM_181886.3_1 - 3.4e-51 172.4 0.0 4.7e-51 172.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Homeobox PF00046.27 NM_014621.2_1 - 1.2e-21 76.1 8.8 1.9e-21 75.5 8.8 1.3 1 0 0 1 1 1 1 Homeobox domain SR-25 PF10500.7 NM_014621.2_1 - 0.026 14.0 3.0 0.038 13.5 3.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DGF-1_C PF11040.6 NM_014621.2_1 - 0.057 13.3 0.7 0.14 12.1 0.7 1.6 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2209 PF09974.7 NM_014621.2_1 - 0.16 12.2 0.1 0.24 11.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeobox_KN PF05920.9 NM_014621.2_1 - 0.17 11.7 0.9 0.35 10.7 0.9 1.5 1 0 0 1 1 1 0 Homeobox KN domain ARD PF03079.12 NM_018269.3_3 - 4.6e-57 192.5 0.1 5.9e-57 192.1 0.1 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.9 NM_018269.3_3 - 1.3e-07 31.1 0.0 2.4e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.17 NM_018269.3_3 - 0.00011 22.0 0.1 0.00017 21.4 0.1 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.10 NM_018269.3_3 - 0.15 11.5 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Laminin_N PF00055.15 NM_001302996.1_2 - 1.3e-79 267.0 0.0 1.3e-79 267.0 0.0 2.3 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.22 NM_001302996.1_2 - 3.5e-09 36.5 43.6 1.5e-06 28.1 10.9 3.4 3 0 0 3 3 3 2 Laminin EGF domain R3H PF01424.20 NM_001282800.1_1 - 6.3e-12 45.2 0.0 1.2e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 R3H domain SUZ PF12752.5 NM_001282800.1_1 - 7.3e-12 45.7 6.0 7.3e-12 45.7 6.0 3.2 3 0 0 3 3 3 1 SUZ domain Sema PF01403.17 NM_006080.2_1 - 6.4e-159 529.1 0.0 8.9e-159 528.7 0.0 1.2 1 0 0 1 1 1 1 Sema domain V-set PF07686.15 NM_006080.2_1 - 0.00021 21.3 0.0 0.00041 20.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 NM_006080.2_1 - 0.00022 21.2 0.0 0.00051 20.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 NM_006080.2_1 - 0.0063 16.9 6.1 0.02 15.3 6.1 1.9 1 0 0 1 1 1 1 Plexin repeat Ig_3 PF13927.4 NM_006080.2_1 - 0.014 15.9 0.0 0.034 14.6 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.4 NM_006080.2_1 - 0.11 12.7 0.0 0.37 11.0 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin domain DUF2205 PF10224.7 NM_001153552.1_1 - 3.8e-18 65.1 0.2 6e-18 64.5 0.2 1.2 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) HALZ PF02183.16 NM_001153552.1_1 - 0.015 15.3 0.3 0.033 14.2 0.3 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper bZIP_1 PF00170.19 NM_001153552.1_1 - 0.038 14.0 0.4 0.071 13.1 0.4 1.4 1 0 0 1 1 1 0 bZIP transcription factor RGS PF00615.17 NM_183337.2_3 - 4.1e-32 110.8 0.0 6.6e-32 110.1 0.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.19 NM_183337.2_3 - 8.8e-16 57.6 0.0 1.5e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.20 NM_183337.2_3 - 3.9e-10 39.4 0.0 1.1e-09 38.0 0.0 1.7 2 0 0 2 2 2 1 GGL domain EF-hand_4 PF12763.5 NM_001163544.2_3 - 0.025 14.4 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Guanylate_kin PF00625.19 NM_001159391.1_2 - 4.2e-69 231.7 0.0 5.1e-69 231.5 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.4 NM_001159391.1_2 - 1.7e-06 28.1 0.4 1.9e-05 24.7 0.4 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.4 NM_001159391.1_2 - 4.8e-06 27.0 0.0 9.8e-06 26.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 NM_001159391.1_2 - 1.7e-05 25.2 1.5 6.1e-05 23.3 1.5 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 NM_001159391.1_2 - 0.00043 20.1 0.1 0.00094 19.0 0.0 1.6 2 0 0 2 2 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.25 NM_001159391.1_2 - 0.00058 20.3 0.1 0.00079 19.8 0.1 1.5 1 1 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.21 NM_001159391.1_2 - 0.00067 19.6 0.0 0.0013 18.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 NM_001159391.1_2 - 0.00068 19.8 0.1 0.0018 18.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.4 NM_001159391.1_2 - 0.0039 16.8 0.0 0.0069 16.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain cobW PF02492.17 NM_001159391.1_2 - 0.0044 16.5 0.1 0.012 15.1 0.1 1.6 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.10 NM_001159391.1_2 - 0.0045 16.8 0.1 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.4 NM_001159391.1_2 - 0.0049 16.5 0.1 0.042 13.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.4 NM_001159391.1_2 - 0.011 15.9 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 NM_001159391.1_2 - 0.013 15.1 0.0 0.49 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 NM_001159391.1_2 - 0.017 14.3 0.1 0.036 13.2 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.4 NM_001159391.1_2 - 0.03 14.2 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 NM_001159391.1_2 - 0.03 14.6 0.0 0.05 13.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.13 NM_001159391.1_2 - 0.031 14.1 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 NTPase dNK PF01712.17 NM_001159391.1_2 - 0.033 13.9 0.1 0.81 9.4 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase DUF2075 PF09848.7 NM_001159391.1_2 - 0.044 12.9 0.1 0.9 8.6 0.1 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.12 NM_001159391.1_2 - 0.059 13.2 1.1 0.43 10.4 0.1 2.6 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.4 NM_001159391.1_2 - 0.064 13.5 0.1 0.71 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.27 NM_001159391.1_2 - 0.088 13.1 0.0 0.23 11.7 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.15 NM_001159391.1_2 - 0.098 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.16 NM_001159391.1_2 - 0.11 12.3 0.0 0.18 11.5 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Dynamin_N PF00350.21 NM_001159391.1_2 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Dynamin family Rad17 PF03215.13 NM_001159391.1_2 - 0.16 10.7 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Roc PF08477.11 NM_001159391.1_2 - 0.19 11.8 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.4 NM_001159391.1_2 - 1 9.7 3.2 3.1 8.1 3.2 1.9 1 1 0 1 1 1 0 AAA domain IL1 PF00340.17 NM_173841.2_1 - 3.2e-38 130.0 0.0 5e-38 129.4 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 Rad60-SLD_2 PF13881.4 NM_007106.3_3 - 3.7e-30 104.2 0.0 5.5e-30 103.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 NM_007106.3_3 - 0.011 15.3 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family SIT PF15330.4 NM_001289085.1_3 - 5.7e-34 116.8 0.7 9.6e-34 116.1 0.7 1.4 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT V-set PF07686.15 NM_001289085.1_3 - 6e-12 45.5 0.9 1e-11 44.8 0.9 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain TMEM154 PF15102.4 NM_001289085.1_3 - 0.098 12.4 0.3 0.29 10.9 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family ig PF00047.23 NM_001289085.1_3 - 0.2 11.7 2.9 1.2 9.2 2.9 2.1 1 1 0 1 1 1 0 Immunoglobulin domain TGF_beta PF00019.18 NM_057090.2_3 - 1.2e-11 45.2 0.0 3.2e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 Transforming growth factor beta like domain FAD_binding_1 PF00667.18 NM_014434.3_1 - 1.6e-44 152.0 0.0 2.1e-44 151.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 NM_014434.3_1 - 8.9e-31 106.9 0.0 1.3e-30 106.4 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 NM_014434.3_1 - 1.1e-11 45.2 0.0 1.7e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain zf-RING_2 PF13639.4 NM_014434.3_3 - 2.1e-08 34.1 4.3 1.1e-07 31.8 4.3 2.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_014434.3_3 - 5.2e-07 29.4 2.7 5.2e-07 29.4 2.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 NM_014434.3_3 - 6.3e-07 29.0 4.0 2.1e-06 27.4 4.0 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_014434.3_3 - 2.4e-05 24.0 2.1 7.5e-05 22.4 2.1 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.4 NM_014434.3_3 - 0.00017 21.1 2.2 0.00017 21.1 2.2 2.3 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.4 NM_014434.3_3 - 0.0017 18.2 3.0 0.0017 18.2 3.0 2.4 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.4 NM_014434.3_3 - 0.0032 17.2 3.0 0.026 14.3 3.2 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.3 NM_014434.3_3 - 0.023 14.3 4.4 0.03 13.9 0.1 2.7 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_2 PF13923.4 NM_014434.3_3 - 0.03 14.0 3.4 0.15 11.8 3.4 2.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_014434.3_3 - 0.032 14.3 3.5 0.14 12.2 3.5 2.2 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Ig_2 PF13895.4 NM_001288832.1_3 - 4.2e-20 71.8 0.0 1.9e-10 40.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001288832.1_3 - 1.3e-07 31.9 0.3 0.0028 18.1 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain CECR6_TMEM121 PF14997.4 NM_031890.3_2 - 1.7e-56 191.0 0.0 2.8e-56 190.3 0.0 1.3 1 0 0 1 1 1 1 CECR6/TMEM121 family PAX PF00292.16 NM_013945.2_2 - 1.1e-73 245.0 0.8 1.7e-73 244.3 0.8 1.3 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 NM_013945.2_2 - 2.5e-23 81.5 6.8 4.7e-23 80.6 6.8 1.5 1 0 0 1 1 1 1 Homeobox domain Pax7 PF12360.6 NM_013945.2_2 - 7.7e-20 70.7 8.3 1.9e-19 69.5 8.3 1.7 1 0 0 1 1 1 1 Paired box protein 7 Homeobox_KN PF05920.9 NM_013945.2_2 - 5.4e-05 22.9 0.8 0.00015 21.5 0.8 1.8 1 0 0 1 1 1 1 Homeobox KN domain HTH_23 PF13384.4 NM_013945.2_2 - 0.00017 21.1 2.2 0.0042 16.7 0.1 2.6 2 0 0 2 2 2 1 Homeodomain-like domain PAS_11 PF14598.4 NM_004898.3_1 - 6.4e-22 77.7 0.0 8.6e-20 70.8 0.0 2.8 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.10 NM_004898.3_1 - 8.8e-17 61.0 0.3 4.8e-15 55.5 0.1 2.4 2 0 0 2 2 2 1 PAS fold HLH PF00010.24 NM_004898.3_1 - 8.3e-09 35.2 0.6 1.7e-08 34.1 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.23 NM_004898.3_1 - 9.6e-09 35.1 0.0 4.4e-07 29.7 0.0 2.7 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.5 NM_004898.3_1 - 0.00026 21.1 0.0 0.0033 17.5 0.0 2.4 2 0 0 2 2 2 1 PAS domain Ribosomal_L16 PF00252.16 NM_017840.3_2 - 1.5e-29 102.6 0.0 2.1e-29 102.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Na_H_Exchanger PF00999.19 NM_004594.2_1 - 1.1e-86 290.9 41.7 1.3e-86 290.6 41.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.3 NM_004594.2_1 - 0.0091 16.1 0.3 0.018 15.1 0.3 1.4 1 0 0 1 1 1 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin PIG-H PF10181.7 NM_004594.2_1 - 0.11 12.2 0.4 0.36 10.6 0.4 1.9 1 0 0 1 1 1 0 GPI-GlcNAc transferase complex, PIG-H component RRM_1 PF00076.20 NM_012207.2_2 - 4.9e-21 74.2 0.0 2.3e-10 40.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fez1 PF06818.13 NM_001243438.1_3 - 0.0013 19.0 1.8 0.0013 19.0 1.8 4.4 2 1 1 3 3 3 1 Fez1 Cytochrom_C_2 PF01322.18 NM_001243438.1_3 - 0.34 11.7 9.2 0.91 10.3 2.3 3.1 2 1 0 2 2 2 0 Cytochrome C' DUF4636 PF15468.4 NM_145268.3_3 - 6e-139 461.5 9.8 7.3e-139 461.2 9.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4636) MAP17 PF15807.3 NM_145268.3_3 - 3.6 7.7 10.4 0.16 12.1 0.7 2.3 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Presenilin PF01080.15 NM_145268.3_3 - 6 5.4 10.4 9 4.8 10.4 1.3 1 0 0 1 1 1 0 Presenilin PDZ PF00595.22 NM_001261407.1_1 - 5.7e-189 612.9 58.4 1.6e-19 69.9 0.0 13.3 13 0 0 13 13 13 13 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001261407.1_1 - 3.2e-66 219.5 26.2 7.7e-06 26.0 0.1 13.3 13 0 0 13 13 13 12 PDZ domain L27_2 PF09045.8 NM_001261407.1_1 - 3e-34 116.6 5.6 6.7e-34 115.5 5.6 1.6 1 0 0 1 1 1 1 L27_2 MPDZ_u10 PF16667.3 NM_001261407.1_1 - 8.6e-31 106.5 11.5 8.6e-31 106.5 11.5 3.1 2 0 0 2 2 2 1 Unstructured region 10 on multiple PDZ protein L27_1 PF09058.8 NM_001261407.1_1 - 0.061 13.3 0.7 0.16 11.9 0.7 1.7 1 0 0 1 1 1 0 L27_1 Phage_head_fibr PF11133.6 NM_001261407.1_1 - 0.07 12.4 1.2 1.4 8.1 0.0 3.0 3 0 0 3 3 3 0 Head fiber protein Stathmin PF00836.17 NM_007029.3_2 - 8.3e-56 187.6 24.2 1.3e-55 187.0 24.2 1.3 1 0 0 1 1 1 1 Stathmin family CSRNP_N PF16019.3 NM_033027.3_2 - 2.3e-90 302.2 5.8 2.3e-90 302.2 5.8 1.5 2 0 0 2 2 2 1 Cysteine/serine-rich nuclear protein N-terminus DUF4667 PF15700.3 NM_033027.3_2 - 0.013 15.5 1.1 2.5 8.0 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) TRM PF02005.14 NM_001136035.2_1 - 5.1e-152 506.3 0.0 6e-152 506.1 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase zf-CCCH PF00642.22 NM_001136035.2_1 - 4.7e-07 29.4 5.9 9.8e-07 28.4 5.9 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Met_10 PF02475.14 NM_001136035.2_1 - 3e-06 27.0 0.0 5.2e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Torus PF16131.3 NM_001136035.2_1 - 0.00046 20.7 0.4 0.00095 19.7 0.4 1.5 1 0 0 1 1 1 1 Torus domain Cons_hypoth95 PF03602.13 NM_001136035.2_1 - 0.0026 17.3 0.0 0.0048 16.4 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 BAAT_C PF08840.9 NM_001037162.1_2 - 1.1e-82 277.0 0.0 1.4e-82 276.7 0.0 1.1 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.11 NM_001037162.1_2 - 1.2e-06 28.2 0.0 1.9e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.16 NM_001037162.1_2 - 1.5e-06 27.8 0.1 0.0075 15.7 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.19 NM_001037162.1_2 - 0.00013 21.3 0.0 0.0011 18.3 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.18 NM_001037162.1_2 - 0.067 12.7 0.0 0.17 11.4 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold LRR_8 PF13855.4 NM_001309474.1_1 - 2e-11 43.3 2.0 5.8e-10 38.6 0.7 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 NM_001309474.1_1 - 5.3e-05 23.3 1.9 0.037 14.3 0.2 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001309474.1_1 - 0.0013 18.7 3.6 3.3 8.4 0.0 4.7 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_9 PF14580.4 NM_001309474.1_1 - 0.062 12.7 0.3 0.15 11.5 0.3 1.6 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.4 NM_001309474.1_1 - 0.37 10.8 5.9 12 6.2 0.1 3.9 4 0 0 4 4 4 0 Leucine Rich repeat UQ_con PF00179.24 NM_173469.3_1 - 4.8e-09 35.9 0.0 3.2e-08 33.2 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin-conjugating enzyme RWD PF05773.20 NM_173469.3_1 - 9e-05 22.6 0.5 0.00057 20.0 0.2 2.1 2 0 0 2 2 2 1 RWD domain Prok-E2_B PF14461.4 NM_173469.3_1 - 0.075 12.6 0.0 0.22 11.1 0.0 1.7 2 0 0 2 2 2 0 Prokaryotic E2 family B CUT PF02376.13 NM_001322875.1_1 - 9.6e-45 150.5 3.8 4e-23 81.2 0.1 2.8 3 0 0 3 3 3 2 CUT domain CUTL PF16557.3 NM_001322875.1_1 - 1.9e-42 143.2 2.6 2.1e-42 143.0 0.6 2.3 3 0 0 3 3 3 1 CUT1-like DNA-binding domain of SATB ULD PF16534.3 NM_001322875.1_1 - 2.3e-36 124.0 0.1 2.3e-36 124.0 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin-like oligomerisation domain of SATB Homeobox PF00046.27 NM_001322875.1_1 - 2.5e-07 30.3 0.0 4.9e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Homeobox domain SUIM_assoc PF16619.3 NM_001322875.1_1 - 0.52 10.3 12.0 0.023 14.7 6.0 1.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 IL8 PF00048.18 NM_002982.3_2 - 3.3e-22 78.3 2.9 5.3e-22 77.6 2.9 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Dynactin_p62 PF05502.11 NM_001135644.1_1 - 1.5e-29 103.0 15.1 7.1e-15 54.6 2.2 2.4 1 1 0 2 2 2 2 Dynactin p62 family Pribosyl_synth PF14572.4 NM_002767.3_2 - 5.9e-101 336.0 1.5 8.4e-101 335.5 1.5 1.2 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.4 NM_002767.3_2 - 2.3e-39 133.8 0.6 4.3e-39 132.9 0.6 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.25 NM_002767.3_2 - 3e-08 33.2 0.2 1.8e-06 27.4 0.1 2.2 2 0 0 2 2 2 2 Phosphoribosyl transferase domain UN_NPL4 PF11543.6 NM_002767.3_2 - 0.02 15.2 0.0 0.039 14.3 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 MARVEL PF01284.21 NM_001290194.1_1 - 1e-34 119.5 32.2 7.4e-20 71.3 5.7 3.1 2 0 0 2 2 2 2 Membrane-associating domain Piwi PF02171.15 NM_024852.3_1 - 6.5e-112 373.5 0.0 9.2e-112 373.0 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 NM_024852.3_1 - 1.9e-32 111.2 0.4 5.1e-32 109.9 0.1 1.9 2 0 0 2 2 2 1 Mid domain of argonaute PAZ PF02170.20 NM_024852.3_1 - 6e-29 100.5 0.9 9.5e-29 99.8 0.9 1.3 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.3 NM_024852.3_1 - 4.7e-25 88.7 0.0 1.1e-24 87.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 NM_024852.3_1 - 7.4e-23 79.8 0.0 1.6e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.3 NM_024852.3_1 - 3.2e-12 46.5 0.3 7.7e-12 45.2 0.0 1.9 2 0 0 2 2 2 1 Argonaute linker 2 domain KIND PF16474.3 NM_032451.1_2 - 1.8e-65 220.4 0.0 2.7e-65 219.7 0.0 1.3 1 0 0 1 1 1 1 Kinase non-catalytic C-lobe domain PrmA PF06325.11 NM_032451.1_2 - 0.12 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FYVE PF01363.19 NM_032451.1_2 - 1.5 8.9 12.2 5.2 7.1 12.2 2.0 1 1 0 1 1 1 0 FYVE zinc finger FYVE_2 PF02318.14 NM_032451.1_2 - 5.8 7.0 11.1 0.25 11.4 4.9 1.9 2 0 0 2 2 2 0 FYVE-type zinc finger UCH PF00443.27 NM_001283042.1_1 - 2.9e-53 180.8 0.1 1.1e-52 178.9 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001283042.1_1 - 5.2e-15 55.7 7.0 4.2e-13 49.5 0.6 3.9 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.18 NM_001283042.1_1 - 0.00014 21.4 10.3 0.0021 17.7 1.3 4.0 4 0 0 4 4 4 2 Ubiquitin interaction motif UBA_4 PF14555.4 NM_001283042.1_1 - 0.002 17.8 0.3 0.0078 15.9 0.3 2.0 1 0 0 1 1 1 1 UBA-like domain Gelsolin PF00626.20 NM_001747.3_2 - 2e-58 194.1 0.0 1.2e-19 69.8 0.0 3.2 3 0 0 3 3 3 3 Gelsolin repeat bZIP_1 PF00170.19 NM_001135049.1_2 - 1.9e-09 37.4 20.8 1.9e-09 37.4 20.8 2.1 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001135049.1_2 - 2.1e-06 27.6 21.8 2.1e-06 27.6 21.8 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001135049.1_2 - 7.1e-06 26.3 15.4 1.8e-05 25.0 15.4 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor Macoilin PF09726.7 NM_001135049.1_2 - 2.4 6.5 10.3 3.4 6.0 10.3 1.1 1 0 0 1 1 1 0 Transmembrane protein Mtp PF03821.14 NM_006762.2_2 - 1.2e-126 420.8 14.1 1.5e-126 420.5 14.1 1.1 1 0 0 1 1 1 1 Golgi 4-transmembrane spanning transporter DUF4728 PF15860.3 NM_006762.2_2 - 5 7.6 20.4 0.23 11.9 4.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4728) ERG4_ERG24 PF01222.15 NM_194442.2_3 - 1.5e-160 534.6 12.7 2.1e-160 534.1 12.7 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family LBR_tudor PF09465.8 NM_194442.2_3 - 5.1e-31 106.1 0.2 1e-30 105.2 0.2 1.5 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain DUF1295 PF06966.10 NM_194442.2_3 - 1.6e-06 27.7 0.8 4.5e-06 26.2 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) PEMT PF04191.11 NM_194442.2_3 - 0.0011 19.1 0.1 0.0039 17.4 0.1 1.9 1 0 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.12 NM_194442.2_3 - 0.0016 18.7 3.6 0.0022 18.2 0.4 2.7 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Ras PF00071.20 NM_002867.3_1 - 1.3e-58 197.1 0.5 1.8e-58 196.6 0.5 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_002867.3_1 - 7.4e-32 110.0 0.6 1.2e-31 109.3 0.6 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_002867.3_1 - 8.5e-12 44.7 0.1 1.3e-11 44.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 NM_002867.3_1 - 0.011 15.0 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 NM_002867.3_1 - 0.018 15.0 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_002867.3_1 - 0.033 13.4 0.0 0.053 12.7 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 NM_002867.3_1 - 0.076 12.4 0.1 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Gal-3-0_sulfotr PF06990.9 NM_024637.4_1 - 2e-107 359.4 0.4 4.2e-55 187.1 0.0 2.1 2 0 0 2 2 2 2 Galactose-3-O-sulfotransferase Annexin PF00191.18 NM_001278408.1_1 - 1.5e-101 332.3 12.5 8.6e-26 89.7 0.3 4.6 5 0 0 5 5 5 4 Annexin Pyr_redox_3 PF13738.4 NM_182981.2_2 - 2.6e-08 33.3 0.0 1.4e-06 27.7 0.0 3.0 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 NM_182981.2_2 - 7.2e-07 28.6 0.0 2.9e-05 23.3 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 NM_182981.2_2 - 0.005 15.9 0.0 0.013 14.5 0.0 1.6 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) 7tm_4 PF13853.4 NM_001005162.2_1 - 8e-98 327.5 26.3 9.9e-98 327.1 26.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005162.2_1 - 1.2e-18 67.2 25.3 3e-18 65.9 25.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001005162.2_1 - 1.6e-06 27.6 19.1 2.3e-06 27.0 18.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx FhuF_C PF11575.6 NM_175911.3_1 - 3.1 7.7 7.0 0.66 9.8 0.2 3.0 3 0 0 3 3 3 0 FhuF 2Fe-2S C-terminal domain 7tm_4 PF13853.4 NM_175911.3_2 - 4.1e-44 151.3 17.4 6.3e-44 150.7 17.4 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_175911.3_2 - 3.9e-24 85.2 15.1 7.8e-24 84.2 15.1 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ARL17 PF15840.3 NM_175911.3_2 - 0.11 12.7 1.9 2.7 8.3 0.2 2.5 1 1 1 2 2 2 0 ADP-ribosylation factor-like protein 17 2OG-FeII_Oxy_2 PF13532.4 NM_139178.3_3 - 3.9e-28 98.9 0.0 5.5e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3265 PF11665.6 NM_015641.3_2 - 0.0071 16.4 0.6 0.023 14.8 0.6 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3265) PET PF06297.12 NM_015641.3_3 - 1.4e-40 137.3 2.7 2.7e-40 136.4 2.7 1.5 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 NM_015641.3_3 - 1e-25 89.6 62.7 9.2e-14 51.3 8.1 4.7 5 1 1 6 6 6 3 LIM domain Ig_Tie2_1 PF10430.7 NM_015641.3_3 - 0.058 13.7 0.0 0.23 11.7 0.0 2.0 1 0 0 1 1 1 0 Tie-2 Ig-like domain 1 Peptidase_C2 PF00648.19 NM_001748.4_3 - 5.5e-128 426.0 0.0 7.9e-128 425.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 NM_001748.4_3 - 7.8e-55 184.9 0.0 1.2e-54 184.3 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 NM_001748.4_3 - 3.6e-10 38.5 1.1 0.021 14.2 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_001748.4_3 - 6.1e-09 35.0 1.1 0.068 13.0 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 NM_001748.4_3 - 2.8e-08 33.3 1.2 3.8e-07 29.6 0.2 2.8 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.4 NM_001748.4_3 - 0.00017 21.9 6.9 1.3 9.4 1.0 4.6 3 1 1 4 4 4 2 EF-hand domain pair zf-H2C2_2 PF13465.4 NM_001256653.1_2 - 0.17 12.2 5.8 0.81 10.1 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001256653.1_2 - 2.9 8.4 9.7 8.6 6.9 1.1 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001256653.1_3 - 8.6e-145 465.2 214.9 1.5e-08 34.6 1.1 25.8 25 0 0 25 25 24 23 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001256653.1_3 - 1.4e-92 299.2 191.7 2.2e-06 27.7 1.2 25.3 26 0 0 26 26 24 21 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_001256653.1_3 - 1.6e-39 133.0 163.7 0.00019 21.2 0.5 24.5 25 0 0 25 25 24 20 C2H2-type zinc finger zf-C2H2_4 PF13894.4 NM_001256653.1_3 - 1e-38 128.5 180.2 0.008 16.8 0.7 26.1 26 0 0 26 26 25 20 C2H2-type zinc finger KRAB PF01352.25 NM_001256653.1_3 - 1.9e-21 75.3 0.6 4e-21 74.3 0.2 1.8 2 0 0 2 2 2 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001256653.1_3 - 2.6e-16 59.3 141.1 0.058 13.4 3.5 17.5 8 5 14 22 22 22 15 Zinc ribbon domain XPA_N PF01286.16 NM_001256653.1_3 - 2.5e-15 56.1 123.9 0.92 9.5 0.1 22.9 23 0 0 23 23 23 13 XPA protein N-terminal zf-C2H2_jaz PF12171.6 NM_001256653.1_3 - 1.5e-07 31.4 120.0 0.31 11.3 0.2 22.3 22 0 0 22 22 22 7 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_001256653.1_3 - 1.7e-05 24.4 77.6 1.8 8.3 0.3 19.4 22 0 0 22 22 22 3 zinc-finger C2H2-type MRP-S23 PF10484.7 NM_001256653.1_3 - 0.0042 17.2 0.0 57 3.8 0.0 5.7 4 2 1 5 5 5 0 Mitochondrial ribosomal protein S23 zinc_ribbon_15 PF17032.3 NM_001256653.1_3 - 0.0049 17.4 121.4 0.66 10.6 3.2 12.2 3 2 8 12 12 11 9 zinc-ribbon family C1_4 PF07975.10 NM_001256653.1_3 - 8.6 6.6 114.7 0.99 9.6 3.0 15.1 1 1 18 20 20 20 0 TFIIH C1-like domain Clathrin PF00637.18 NM_001288653.1_3 - 1.9e-207 679.3 39.0 3.6e-34 117.5 1.4 7.8 7 1 1 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.18 NM_001288653.1_3 - 1.5e-48 160.6 2.3 5.1e-08 32.7 0.0 6.8 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.4 NM_001288653.1_3 - 2.9e-32 110.2 0.3 9.9e-32 108.5 0.3 2.0 1 0 0 1 1 1 1 Clathrin-H-link Clathrin-link PF09268.8 NM_001288653.1_3 - 2.9e-14 52.0 0.8 7.6e-14 50.6 0.8 1.8 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.12 NM_001288653.1_3 - 5.2e-07 29.0 1.0 2.7e-05 23.3 0.2 2.9 2 0 0 2 2 2 1 Coatomer WD associated region TPR_7 PF13176.4 NM_001288653.1_3 - 0.00052 19.7 9.8 2.1 8.4 0.1 7.5 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001288653.1_3 - 0.003 17.9 1.5 11 6.5 0.0 5.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001288653.1_3 - 0.016 14.9 7.6 0.4 10.4 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001288653.1_3 - 0.14 12.9 16.7 37 5.4 0.0 7.9 7 1 1 8 8 7 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001288653.1_3 - 0.28 11.3 10.1 7.5 6.8 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001288653.1_3 - 2.1 8.6 10.3 12 6.3 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat Globin PF00042.20 NM_203378.1_3 - 1.1e-21 77.3 0.3 1.6e-21 76.8 0.3 1.3 1 0 0 1 1 1 1 Globin TF_AP-2 PF03299.12 NM_003221.3_2 - 3.5e-87 291.3 0.0 4.7e-87 290.9 0.0 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 Myotub-related PF06602.12 NM_016156.5_2 - 2.6e-154 513.1 0.0 3.6e-154 512.7 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.18 NM_016156.5_2 - 6.3e-20 71.0 0.0 1.3e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Y_phosphatase PF00102.25 NM_016156.5_2 - 0.00061 19.3 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase 3-PAP PF12578.6 NM_016156.5_2 - 0.0046 16.6 0.0 0.0097 15.5 0.0 1.5 1 0 0 1 1 1 1 Myotubularin-associated protein DSPc PF00782.18 NM_016156.5_2 - 0.0077 15.9 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain NYD-SP28_assoc PF14775.4 NM_016156.5_2 - 0.082 12.9 2.1 2.8 8.0 0.6 3.3 3 0 0 3 3 3 0 Sperm tail C-terminal domain Y_phosphatase3 PF13350.4 NM_016156.5_2 - 0.14 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family COesterase PF00135.26 NM_003235.4_3 - 8.8e-129 430.6 0.0 1.2e-128 430.1 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Thyroglobulin_1 PF00086.16 NM_003235.4_3 - 3.6e-126 410.8 101.2 4.9e-15 54.8 0.9 12.8 11 1 1 12 12 12 12 Thyroglobulin type-1 repeat Ephrin_rec_like PF07699.11 NM_003235.4_3 - 3.6e-15 55.3 8.3 3.4e-14 52.2 3.5 3.4 1 1 1 2 2 2 2 Putative ephrin-receptor like Abhydrolase_3 PF07859.11 NM_003235.4_3 - 0.032 13.9 0.2 0.062 13.0 0.2 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Myosin_N PF02736.17 NM_003235.4_3 - 0.07 12.8 0.2 0.48 10.1 0.0 2.6 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain SNF PF00209.16 NM_003044.4_2 - 6.6e-242 803.7 38.7 7.9e-242 803.4 38.7 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family PseudoU_synth_2 PF00849.20 NM_001324411.1_1 - 1.6e-11 44.4 0.0 2.4e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase PseudoU_synth_2 PF00849.20 NM_001324411.1_3 - 7.9e-07 29.2 0.0 1.2e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase MRG PF05712.11 NM_001142425.1_2 - 1.5e-52 177.7 0.4 2.1e-52 177.2 0.4 1.2 1 0 0 1 1 1 1 MRG RRM_1 PF00076.20 NM_001322446.1_1 - 3.8e-08 32.9 0.0 5.9e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PI3Ka PF00613.18 NM_001256045.1_2 - 6.4e-63 211.4 0.1 1.1e-62 210.6 0.1 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.25 NM_001256045.1_2 - 2.8e-61 207.4 0.0 4.7e-61 206.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.4 NM_001256045.1_2 - 0.12 11.5 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Ribosomal_L26 PF16906.3 NM_001317982.1_2 - 2.5e-43 146.4 5.7 3.4e-43 145.9 5.7 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.27 NM_001317982.1_2 - 7.9e-08 31.9 4.4 2.1e-07 30.5 4.4 1.8 1 0 0 1 1 1 1 KOW motif eIF-5_eIF-2B PF01873.15 NM_001317982.1_2 - 0.67 9.7 5.4 9 6.1 0.1 2.6 3 0 0 3 3 3 0 Domain found in IF2B/IF5 PINIT PF14324.4 NM_004671.4_2 - 1.2e-34 119.6 0.0 2e-34 118.9 0.0 1.3 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.18 NM_004671.4_2 - 4.3e-21 74.3 5.2 9.5e-21 73.2 5.2 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 NM_004671.4_2 - 0.0018 17.9 1.6 0.004 16.8 1.6 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.25 NM_004671.4_2 - 0.12 12.0 0.1 0.36 10.5 0.0 1.9 2 0 0 2 2 2 0 SAP domain Pkinase_Tyr PF07714.15 NM_001297652.1_3 - 5.3e-84 281.4 0.0 6.7e-84 281.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001297652.1_3 - 9.1e-38 130.0 0.0 1.1e-36 126.4 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 NM_001297652.1_3 - 4.4e-20 72.0 0.0 6.8e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Lamprin PF06403.9 NM_001297652.1_3 - 0.035 13.9 0.5 0.078 12.8 0.5 1.5 1 0 0 1 1 1 0 Lamprin Kinase-like PF14531.4 NM_001297652.1_3 - 0.082 12.1 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like DUF872 PF05915.10 NM_025124.3_2 - 3.4e-48 162.5 0.1 4.6e-48 162.1 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) DUF3040 PF11239.6 NM_025124.3_2 - 0.22 11.7 6.0 0.58 10.3 4.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) DUF308 PF03729.11 NM_025124.3_2 - 0.38 11.0 7.0 0.85 9.9 7.0 1.6 1 1 0 1 1 1 0 Short repeat of unknown function (DUF308) IncA PF04156.12 NM_025124.3_2 - 0.73 9.5 4.5 1.1 8.8 4.5 1.2 1 0 0 1 1 1 0 IncA protein Neurensin PF14927.4 NM_025124.3_2 - 1.6 8.3 3.2 1.7 8.3 0.4 2.0 1 1 1 2 2 2 0 Neurensin MFS_1 PF07690.14 NM_001167903.1_3 - 5.2e-34 117.6 58.3 4.1e-23 81.7 34.0 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.4 NM_001167903.1_3 - 1.8e-07 29.9 21.5 1.8e-07 29.9 21.5 2.1 2 0 0 2 2 2 1 MFS/sugar transport protein Zn_ribbon_recom PF13408.4 NM_015963.5_1 - 9.1 6.8 9.5 26 5.3 6.5 2.4 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain DUF1794 PF08768.9 NM_015963.5_3 - 2.6e-42 144.2 0.0 3.9e-42 143.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) THAP PF05485.10 NM_015963.5_3 - 9.9e-19 68.0 1.3 9.9e-19 68.0 1.3 2.1 2 0 0 2 2 2 1 THAP domain HrpB7 PF09486.8 NM_015963.5_3 - 0.0056 16.9 0.1 0.0056 16.9 0.1 2.3 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) DUF4201 PF13870.4 NM_015963.5_3 - 0.0071 15.9 0.6 0.012 15.2 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) IncA PF04156.12 NM_015963.5_3 - 0.051 13.2 1.4 0.11 12.1 1.4 1.5 1 0 0 1 1 1 0 IncA protein Tropomyosin_1 PF12718.5 NM_015963.5_3 - 0.12 12.4 1.6 0.33 10.9 1.6 1.7 1 0 0 1 1 1 0 Tropomyosin like TMF_DNA_bd PF12329.6 NM_015963.5_3 - 0.15 11.9 2.0 0.35 10.8 2.0 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.13 NM_015963.5_3 - 0.19 11.4 0.3 0.39 10.4 0.3 1.5 1 0 0 1 1 1 0 Septum formation initiator ATG16 PF08614.9 NM_015963.5_3 - 4.5 7.3 10.8 0.08 13.0 1.6 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) V-set PF07686.15 NM_001008229.2_2 - 5.5e-11 42.5 0.0 1.1e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001008229.2_2 - 3.8e-05 24.1 0.0 0.0002 21.7 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_001008229.2_2 - 8.9e-05 22.4 0.0 0.00027 20.8 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_001008229.2_2 - 0.00032 20.7 0.0 0.0054 16.7 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin domain COX6B PF02297.15 NM_001012985.2_1 - 1.7e-17 63.3 7.7 2.6e-17 62.7 7.7 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CHCH PF06747.11 NM_001012985.2_1 - 0.0014 18.6 3.3 0.0032 17.4 3.3 1.6 1 0 0 1 1 1 1 CHCH domain bZIP_1 PF00170.19 NM_001135047.1_2 - 1.8e-09 37.4 20.8 1.8e-09 37.4 20.8 2.1 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001135047.1_2 - 2e-06 27.7 21.8 2e-06 27.7 21.8 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001135047.1_2 - 6.7e-06 26.4 15.4 1.7e-05 25.1 15.4 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor Macoilin PF09726.7 NM_001135047.1_2 - 2.3 6.5 10.3 3.2 6.0 10.3 1.1 1 0 0 1 1 1 0 Transmembrane protein Ribul_P_3_epim PF00834.17 NM_001278282.1_1 - 2.2e-37 128.3 0.1 8.1e-35 119.9 0.1 2.2 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.17 NM_001278282.1_1 - 0.082 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Ribul_P_3_epim PF00834.17 NM_001278282.1_2 - 5e-06 25.9 0.0 6.9e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family Perilipin PF03036.14 NM_001145311.1_3 - 5.7e-116 387.7 2.1 7.7e-116 387.2 2.1 1.2 1 0 0 1 1 1 1 Perilipin family MIF4G PF02854.17 NM_001242500.1_1 - 8.5e-11 41.8 0.2 1.5e-10 41.0 0.2 1.3 1 0 0 1 1 1 1 MIF4G domain Pkinase_Tyr PF07714.15 NM_016733.2_2 - 1.1e-49 168.9 0.0 7.4e-49 166.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_016733.2_2 - 7.2e-47 159.8 0.0 1.1e-46 159.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PDZ PF00595.22 NM_016733.2_2 - 1.7e-16 60.2 0.0 3e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LIM PF00412.20 NM_016733.2_2 - 1.8e-16 59.9 12.5 1.5e-08 34.6 5.4 2.8 2 0 0 2 2 2 2 LIM domain Kdo PF06293.12 NM_016733.2_2 - 1.2e-05 24.6 0.1 2e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_016733.2_2 - 0.01 15.6 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family PDZ_2 PF13180.4 NM_016733.2_2 - 0.037 14.2 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 PDZ domain zf-RRN7 PF11781.6 NM_016733.2_2 - 1.4 8.6 6.2 0.48 10.0 0.7 2.6 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Methyltransf_25 PF13649.4 NM_001007239.1_3 - 1.8e-19 70.1 0.1 2.5e-13 50.4 0.0 3.2 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001007239.1_3 - 1.1e-16 61.1 0.2 7.3e-14 52.1 0.0 3.8 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001007239.1_3 - 2.2e-16 59.9 0.0 7.3e-12 45.2 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Spermine_synth PF01564.15 NM_001007239.1_3 - 8e-07 28.1 0.1 2.8e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 Spermine/spermidine synthase Methyltransf_12 PF08242.10 NM_001007239.1_3 - 1.4e-06 28.8 0.0 0.00041 20.9 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.4 NM_001007239.1_3 - 2.9e-06 27.2 0.0 5.1e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.10 NM_001007239.1_3 - 0.0098 15.4 0.2 0.017 14.6 0.2 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TPMT PF05724.9 NM_001007239.1_3 - 0.011 15.3 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) MTS PF05175.12 NM_001007239.1_3 - 0.015 14.7 0.0 1.8 7.9 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase small domain Med12-LCEWAV PF12145.6 NM_001007239.1_3 - 0.049 12.3 0.0 0.35 9.5 0.0 1.9 2 0 0 2 2 2 0 Eukaryotic Mediator 12 subunit domain PrmA PF06325.11 NM_001007239.1_3 - 0.13 11.5 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) ADK PF00406.20 NM_001199856.1_1 - 4e-30 104.8 0.0 5.6e-30 104.3 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.12 NM_001199856.1_1 - 1.2e-15 57.0 0.0 2.4e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.4 NM_001199856.1_1 - 0.014 15.7 0.0 0.024 15.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain WWE PF02825.18 NM_020892.2_2 - 3.5e-33 113.8 0.6 4.2e-16 59.1 0.0 2.3 2 0 0 2 2 2 2 WWE domain zf-C3HC4 PF00097.23 NM_020892.2_2 - 0.00014 21.5 4.0 0.00014 21.5 4.0 2.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_020892.2_2 - 0.0017 18.5 2.3 0.0017 18.5 2.3 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.4 NM_020892.2_2 - 0.0058 16.7 4.4 0.0058 16.7 4.4 3.4 3 1 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.3 NM_020892.2_2 - 0.013 15.1 3.9 0.16 11.6 0.3 2.7 2 0 0 2 2 2 0 RING-like zinc finger zf-ANAPC11 PF12861.5 NM_020892.2_2 - 0.015 15.2 0.7 0.065 13.2 0.7 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-UDP PF14569.4 NM_020892.2_2 - 0.08 12.9 0.2 0.08 12.9 0.2 2.1 2 0 0 2 2 2 0 Zinc-binding RING-finger HLH PF00010.24 NM_001008541.1_1 - 2.6e-05 24.0 0.1 0.00038 20.2 0.2 2.4 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain KASH_CCD PF14662.4 NM_001008541.1_1 - 0.022 14.5 4.0 0.034 13.9 4.0 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH CCDC106 PF15794.3 NM_001008541.1_1 - 0.045 13.3 3.2 0.084 12.4 3.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 BRE1 PF08647.9 NM_001008541.1_1 - 0.12 12.3 2.4 0.24 11.4 2.4 1.4 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Ion_trans PF00520.29 NM_001282309.1_1 - 4.8e-33 114.3 34.4 6.5e-33 113.8 34.4 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.10 NM_001282309.1_1 - 0.00035 19.2 25.8 0.0009 17.9 13.8 2.2 1 1 1 2 2 2 2 Polycystin cation channel Neur_chan_memb PF02932.14 NM_001282309.1_1 - 0.00073 19.5 0.2 0.0019 18.2 0.2 1.7 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF3510 PF12022.6 NM_001282309.1_1 - 0.36 11.1 4.7 0.76 10.0 4.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3510) TNFR_c6 PF00020.16 NM_001242310.1_2 - 7.8e-12 45.3 29.7 4.9e-07 29.9 7.6 4.1 3 0 0 3 3 3 2 TNFR/NGFR cysteine-rich region FAM27 PF15832.3 NM_001242310.1_3 - 0.32 11.4 5.4 0.65 10.4 5.4 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family LIM PF00412.20 NM_001159701.1_2 - 1.4e-43 146.8 70.2 2.1e-11 43.7 8.1 5.4 5 0 0 5 5 5 5 LIM domain Ureidogly_lyase PF04115.10 NM_001159701.1_2 - 0.017 14.8 0.8 2.4 7.8 0.0 3.0 2 1 2 4 4 4 0 Ureidoglycolate lyase Y_phosphatase PF00102.25 NM_005704.4_1 - 1.1e-134 447.2 0.0 5.3e-77 258.4 0.0 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase MAM PF00629.21 NM_005704.4_1 - 3.6e-35 121.1 0.0 7.4e-35 120.0 0.0 1.6 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu fn3 PF00041.19 NM_005704.4_1 - 1.5e-29 102.0 0.2 1.7e-12 47.4 0.0 4.6 4 0 0 4 4 4 3 Fibronectin type III domain DSPc PF00782.18 NM_005704.4_1 - 3.9e-06 26.6 0.4 0.11 12.1 0.1 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_005704.4_1 - 0.00019 21.3 0.2 0.036 13.9 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_005704.4_1 - 0.00039 20.5 0.0 0.14 12.2 0.0 2.4 2 0 0 2 2 2 2 Inositol hexakisphosphate Pur_ac_phosph_N PF16656.3 NM_005704.4_1 - 0.0047 17.3 0.1 0.31 11.5 0.0 3.4 3 1 1 4 4 4 1 Purple acid Phosphatase, N-terminal domain PsbX PF06596.9 NM_005704.4_1 - 2.9 7.8 4.6 6.9 6.6 4.6 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) BTB_2 PF02214.20 NM_153033.4_2 - 6.8e-18 64.7 0.0 1.5e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain JmjC PF02373.20 NM_001304339.1_2 - 8.8e-44 148.5 0.1 1.8e-43 147.4 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.4 NM_001304339.1_2 - 5.3e-35 119.8 8.0 5.3e-35 119.8 8.0 2.4 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 NM_001304339.1_2 - 1.8e-17 63.2 2.5 1.8e-17 63.2 2.5 3.5 3 1 1 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.4 NM_001304339.1_2 - 2.9e-12 45.8 10.5 2.9e-12 45.8 10.5 2.7 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.15 NM_001304339.1_2 - 7.9e-12 44.8 0.0 1.7e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 jmjN domain LBR_tudor PF09465.8 NM_001304339.1_2 - 2.5e-06 27.0 0.6 0.0024 17.5 0.1 2.5 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain PHD PF00628.27 NM_001304339.1_2 - 6.2e-05 22.7 5.6 6.2e-05 22.7 5.6 3.1 3 0 0 3 3 3 2 PHD-finger 53-BP1_Tudor PF09038.8 NM_001304339.1_2 - 0.082 12.7 0.1 1.2 9.0 0.0 2.2 1 1 1 2 2 2 0 Tumour suppressor p53-binding protein-1 Tudor LRR_8 PF13855.4 NM_001321678.1_2 - 3.3e-15 55.4 13.7 1.2e-07 31.2 2.7 3.6 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_001321678.1_2 - 3.4e-14 52.5 10.9 2.1e-06 27.8 0.9 4.2 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_001321678.1_2 - 0.13 11.7 2.8 11 5.3 0.2 2.4 1 1 0 2 2 2 0 Leucine-rich repeat ABC_membrane PF00664.21 NM_000544.3_3 - 5.4e-56 190.1 0.3 8.6e-56 189.4 0.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 NM_000544.3_3 - 1e-32 113.4 0.0 1.6e-32 112.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.4 NM_000544.3_3 - 0.00036 20.1 0.1 0.00067 19.2 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.17 NM_000544.3_3 - 0.00061 19.1 1.0 0.0098 15.2 1.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.4 NM_000544.3_3 - 0.00098 18.8 5.3 0.0085 15.7 5.3 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.4 NM_000544.3_3 - 0.001 19.3 0.1 0.0049 17.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 NM_000544.3_3 - 0.0011 19.3 0.4 0.0025 18.1 0.4 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.4 NM_000544.3_3 - 0.0036 16.8 0.0 0.0053 16.3 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.4 NM_000544.3_3 - 0.0049 16.6 0.0 0.0094 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.4 NM_000544.3_3 - 0.0086 15.5 0.5 0.058 12.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.4 NM_000544.3_3 - 0.021 15.2 0.0 0.036 14.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.4 NM_000544.3_3 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.20 NM_000544.3_3 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Peptidase_C14 PF00656.20 NM_033340.3_2 - 4.8e-26 92.1 0.0 6.3e-26 91.7 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Peptidase_C14 PF00656.20 NM_033340.3_3 - 7e-14 52.2 0.0 1.1e-13 51.6 0.0 1.3 1 0 0 1 1 1 1 Caspase domain RhoGEF PF00621.18 NM_018173.3_2 - 6e-35 121.0 0.0 1.3e-34 119.9 0.0 1.6 2 0 0 2 2 2 1 RhoGEF domain PH_5 PF15405.4 NM_018173.3_2 - 0.0016 18.4 0.5 0.0053 16.7 0.5 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 NM_018173.3_2 - 0.0051 17.2 0.0 0.0095 16.3 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 NM_018173.3_2 - 0.097 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Peptidase_S10 PF00450.20 NM_031311.3_3 - 7.4e-104 348.3 0.2 1e-103 347.9 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase SAM_2 PF07647.15 NM_201628.2_3 - 5.2e-27 93.6 1.1 1.2e-10 41.3 0.0 3.5 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_201628.2_3 - 5.4e-26 90.7 3.9 6.4e-12 45.6 0.7 3.5 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) Fez1 PF06818.13 NM_201628.2_3 - 0.0076 16.6 10.6 0.0076 16.6 10.6 2.6 3 0 0 3 3 3 2 Fez1 SAM_PNT PF02198.14 NM_201628.2_3 - 0.03 14.1 1.7 4.3 7.2 0.1 3.1 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain DUF148 PF02520.15 NM_201628.2_3 - 0.048 13.6 5.9 0.11 12.5 5.9 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF148 zf-C4H2 PF10146.7 NM_201628.2_3 - 0.12 12.5 5.0 0.35 11.0 5.0 1.8 1 0 0 1 1 1 0 Zinc finger-containing protein Glucosamine_iso PF01182.18 NM_004285.3_1 - 6.8e-63 212.4 0.0 9.5e-63 211.9 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase G6PD_C PF02781.14 NM_004285.3_1 - 2.8e-59 200.6 0.0 4.4e-59 199.9 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.20 NM_004285.3_1 - 2.6e-35 122.5 0.0 4.1e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain PAP2 PF01569.19 NM_020438.4_2 - 5.1e-18 65.1 5.7 5.1e-18 65.1 5.7 1.9 2 0 0 2 2 2 1 PAP2 superfamily UbiA PF01040.16 NM_020438.4_2 - 0.0036 16.5 7.9 0.0036 16.5 7.9 1.6 2 0 0 2 2 2 1 UbiA prenyltransferase family 7tm_1 PF00001.19 NM_000024.5_3 - 6.2e-69 232.1 14.2 8.9e-69 231.6 14.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_000024.5_3 - 6.2e-14 51.9 17.2 1.4e-13 50.7 17.1 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_000024.5_3 - 1.8e-07 31.0 9.9 1.8e-07 31.0 9.9 2.0 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 NM_000024.5_3 - 2.9e-06 26.7 17.2 5.8e-06 25.7 17.2 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx ANAPC5 PF12862.5 NM_016237.4_3 - 7.3e-33 112.4 10.2 3.4e-31 107.0 1.9 3.8 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 5 TPR_12 PF13424.4 NM_016237.4_3 - 1.8e-10 40.8 15.9 3.8e-06 27.0 0.0 5.0 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.4 NM_016237.4_3 - 6.7e-05 22.5 5.2 0.024 14.4 2.2 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.15 NM_016237.4_3 - 0.0025 17.6 16.7 0.85 9.8 2.2 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_016237.4_3 - 0.012 15.4 7.0 0.11 12.5 0.7 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.26 NM_016237.4_3 - 0.049 13.4 13.4 2.6 7.9 1.3 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.4 NM_016237.4_3 - 0.32 11.8 11.7 32 5.6 0.1 6.7 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_19 PF14559.4 NM_016237.4_3 - 0.88 10.0 21.9 1.6 9.2 0.2 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.12 NM_016237.4_3 - 1 10.0 10.9 13 6.7 0.7 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.4 NM_016237.4_3 - 3.6 8.2 10.7 19 5.9 1.4 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TNF PF00229.16 NM_000595.3_1 - 4.6e-32 110.5 0.1 6.1e-32 110.1 0.1 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family FNIP_M PF14637.4 NM_001008738.2_2 - 2.2e-88 295.9 0.0 4e-88 295.1 0.0 1.4 1 0 0 1 1 1 1 Folliculin-interacting protein middle domain FNIP_C PF14638.4 NM_001008738.2_2 - 5e-70 234.9 0.1 8.5e-70 234.1 0.1 1.4 1 0 0 1 1 1 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.4 NM_001008738.2_2 - 9e-25 88.1 1.7 9e-25 88.1 1.7 2.7 2 1 0 2 2 2 1 Folliculin-interacting protein N-terminus Isochorismatase PF00857.18 NM_024710.2_1 - 1.7e-19 70.5 0.0 3e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family Cyclin_N PF00134.21 NM_001320748.1_1 - 1.1e-18 67.1 1.4 2.3e-18 66.1 1.4 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain HIN PF02760.13 NM_198930.3_2 - 1e-72 243.1 2.5 1.6e-72 242.5 2.5 1.3 1 0 0 1 1 1 1 HIN-200/IF120x domain PYRIN PF02758.14 NM_198930.3_2 - 8.1e-12 45.0 0.1 1.6e-11 44.1 0.1 1.5 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain Cation_ATPase_C PF00689.19 NM_198930.3_2 - 5.3 6.6 7.0 12 5.5 7.0 1.5 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus Patched PF02460.16 NM_000264.3_3 - 4.4e-73 246.6 18.4 8e-43 146.5 0.8 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.6 NM_000264.3_3 - 9e-43 145.6 3.9 9e-43 145.6 3.9 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation AAA_33 PF13671.4 NM_052818.2_1 - 6.8e-15 55.3 0.0 9.8e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 NM_052818.2_1 - 3.1e-05 24.4 0.0 0.00014 22.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 NM_052818.2_1 - 0.00047 19.4 0.0 0.00083 18.6 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.4 NM_052818.2_1 - 0.0017 18.6 0.0 0.0027 18.0 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.4 NM_052818.2_1 - 0.0066 16.1 0.0 0.0097 15.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 NM_052818.2_1 - 0.02 14.2 0.0 0.032 13.5 0.0 1.3 1 1 0 1 1 1 0 Chromatin associated protein KTI12 NACHT PF05729.10 NM_052818.2_1 - 0.067 13.0 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.4 NM_052818.2_1 - 0.075 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.4 NM_052818.2_1 - 0.095 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.19 NM_052818.2_1 - 0.098 11.9 0.1 0.24 10.6 0.0 1.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA PF00004.27 NM_052818.2_1 - 0.14 12.5 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CPT PF07931.10 NM_052818.2_1 - 0.18 11.5 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_25 PF13481.4 NM_052818.2_1 - 0.22 10.9 0.0 0.4 10.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain SDF PF00375.16 NM_004172.4_3 - 2.1e-132 441.7 30.9 2.6e-132 441.4 30.9 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family MT PF12777.5 NM_004172.4_3 - 0.047 12.6 0.0 0.074 11.9 0.0 1.2 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor Guanylate_kin PF00625.19 NM_201596.2_1 - 1.3e-49 168.2 0.1 2.3e-49 167.4 0.1 1.4 1 0 0 1 1 1 1 Guanylate kinase VGCC_beta4Aa_N PF12052.6 NM_201596.2_1 - 6.7e-23 80.4 6.5 2.5e-22 78.6 6.5 2.1 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.26 NM_201596.2_1 - 0.0058 16.1 0.1 0.014 14.8 0.1 1.7 1 0 0 1 1 1 1 SH3 domain Lectin_C PF00059.19 NM_001144894.1_2 - 1.8e-21 76.7 4.5 3.3e-21 75.9 4.5 1.5 1 0 0 1 1 1 1 Lectin C-type domain DUF2170 PF09938.7 NM_001144894.1_2 - 4.1e-06 26.4 0.8 1.3 8.6 0.1 5.4 1 1 6 7 7 7 1 Uncharacterized protein conserved in bacteria (DUF2170) DUF2730 PF10805.6 NM_001144894.1_2 - 8.3e-05 22.5 9.4 0.25 11.3 0.5 3.8 1 1 2 3 3 3 2 Protein of unknown function (DUF2730) Occludin_ELL PF07303.11 NM_001144894.1_2 - 0.00079 20.0 15.1 0.19 12.3 0.4 3.5 1 1 1 3 3 3 1 Occludin homology domain Mhr1 PF12829.5 NM_001144894.1_2 - 0.025 14.5 5.9 48 4.0 0.0 5.8 1 1 5 7 7 7 0 Transcriptional regulation of mitochondrial recombination DUF617 PF04759.11 NM_001144894.1_2 - 0.13 12.2 0.2 15 5.5 0.0 3.1 1 1 3 4 4 4 0 Protein of unknown function, DUF617 Reo_sigmaC PF04582.10 NM_001144894.1_2 - 0.14 11.4 12.2 0.083 12.1 0.3 3.3 2 1 0 3 3 3 0 Reovirus sigma C capsid protein Vps5 PF09325.8 NM_001144894.1_2 - 0.28 10.5 11.0 0.36 10.2 2.6 2.1 1 1 1 2 2 2 0 Vps5 C terminal like DIMCO_N PF16844.3 NM_001144894.1_2 - 1.2 9.3 9.6 9.8 6.4 0.3 3.1 1 1 2 3 3 3 0 Dinitrogenase iron-molybdenum cofactor, N-terminal YceG PF02618.14 NM_001144894.1_2 - 1.2 8.5 6.6 75 2.6 6.6 2.2 1 1 0 1 1 1 0 YceG-like family DUF2357 PF09823.7 NM_001144894.1_2 - 1.8 7.6 10.9 5.3 6.1 0.3 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF2357) HCMV_UL139 PF12507.6 NM_001144894.1_2 - 1.9 8.7 7.7 10 6.4 0.4 3.4 1 1 3 4 4 4 0 Human Cytomegalovirus UL139 protein DUF3422 PF11902.6 NM_001144894.1_2 - 2.5 7.0 13.6 8 5.3 0.5 3.5 1 1 2 4 4 4 0 Protein of unknown function (DUF3422) DUF4665 PF15679.3 NM_001144894.1_2 - 2.7 8.5 6.6 19 5.8 0.3 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4665) BLOC1_2 PF10046.7 NM_001144894.1_2 - 3.1 8.0 16.6 21 5.4 1.8 4.3 1 1 4 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RP-C_C PF11800.6 NM_001144894.1_2 - 3.8 7.4 8.3 30 4.4 5.0 3.1 1 1 2 3 3 3 0 Replication protein C C-terminal region DGCR6 PF07324.9 NM_001144894.1_2 - 5.9 6.3 16.4 3 7.3 1.1 3.6 1 1 3 4 4 4 0 DiGeorge syndrome critical region 6 (DGCR6) protein tRNA-synt_His PF13393.4 NM_001144894.1_2 - 6.2 5.9 10.2 10 5.1 2.0 2.8 1 1 2 3 3 3 0 Histidyl-tRNA synthetase DUF2408 PF10303.7 NM_001144894.1_2 - 7.5 7.0 17.1 90 3.5 2.0 3.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) DUF4795 PF16043.3 NM_001144894.1_2 - 9.2 5.7 13.6 1e+02 2.2 13.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4763 PF15960.3 NM_001144894.1_2 - 9.8 5.3 19.7 38 3.3 7.0 4.6 1 1 4 5 5 5 0 Domain of unknown function (DUF4763) H2TH PF06831.12 NM_001135747.1_1 - 2.9e-13 49.5 0.0 5e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain zf-FPG_IleRS PF06827.12 NM_001135747.1_1 - 0.019 14.7 0.5 0.054 13.2 0.5 1.8 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS TAS2R PF05296.11 NM_176890.2_2 - 3.6e-82 275.7 39.8 4.2e-82 275.5 39.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) PAG PF15347.4 NM_176890.2_2 - 0.54 9.1 0.7 0.78 8.5 0.7 1.3 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched FRG2 PF15315.4 NM_001286820.1_3 - 1.7e-81 272.7 10.2 2.4e-81 272.2 10.2 1.2 1 0 0 1 1 1 1 Facioscapulohumeral muscular dystrophy candidate 2 Collagen PF01391.16 NM_001130103.1_3 - 2.4e-77 254.4 316.5 3.4e-10 39.4 26.8 11.8 5 2 7 12 12 12 11 Collagen triple helix repeat (20 copies) DUF4200 PF13863.4 NM_182496.2_1 - 2.3e-26 92.4 15.9 2.3e-26 92.4 15.9 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF4200) zf-H2C2_2 PF13465.4 NM_152279.3_1 - 1.4e-135 436.0 132.1 8.8e-08 32.1 0.5 24.1 24 0 0 24 24 24 21 Zinc-finger double domain zf-C2H2 PF00096.24 NM_152279.3_1 - 2e-119 383.7 138.9 7.9e-07 29.1 0.9 24.0 23 0 0 23 23 23 22 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_152279.3_1 - 2.4e-58 189.6 140.7 0.0075 16.9 0.8 24.3 24 0 0 24 24 23 20 C2H2-type zinc finger KRAB PF01352.25 NM_152279.3_1 - 7.9e-23 79.7 0.1 1.4e-22 79.0 0.1 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_152279.3_1 - 3.3e-20 71.8 90.3 0.0013 18.7 1.2 14.5 8 5 6 15 15 15 11 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_152279.3_1 - 9.7e-18 63.6 109.0 0.11 12.3 0.4 21.2 21 0 0 21 21 21 12 C2H2-type zinc finger DZR PF12773.5 NM_152279.3_1 - 1.6e-10 40.7 76.8 1.3e+03 -0.6 15.5 11.4 2 2 0 2 2 1 0 Double zinc ribbon ADK_lid PF05191.12 NM_152279.3_1 - 8.7e-07 28.7 50.4 0.005 16.7 0.3 11.6 6 4 6 13 13 13 5 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 NM_152279.3_1 - 9.5e-07 29.3 82.1 0.6 10.8 1.1 11.3 3 2 10 13 13 13 7 zinc-ribbon family C1_4 PF07975.10 NM_152279.3_1 - 8.1e-06 25.9 84.5 1 9.6 1.4 13.5 6 3 4 12 12 12 7 TFIIH C1-like domain DUF3268 PF11672.6 NM_152279.3_1 - 1.8e-05 24.9 79.0 0.41 10.9 0.9 12.6 8 2 6 15 15 15 11 zinc-finger-containing domain zf-C2H2_jaz PF12171.6 NM_152279.3_1 - 3.2e-05 24.0 90.7 0.15 12.3 0.2 18.6 20 0 0 20 20 20 8 Zinc-finger double-stranded RNA-binding ELO PF01151.16 NM_022821.3_1 - 5.2e-63 212.7 23.5 7.2e-63 212.3 23.5 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family SURF1 PF02104.13 NM_003172.3_3 - 1.9e-43 148.6 0.0 2.5e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 SURF1 family Pkinase PF00069.23 NM_145203.5_1 - 2e-26 92.8 0.0 2.9e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_145203.5_1 - 1.3e-14 54.0 0.0 1.8e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.14 NM_145203.5_1 - 0.03 14.3 0.0 0.093 12.8 0.0 1.7 1 0 0 1 1 1 0 ABC1 family BIR PF00653.19 NM_001168.2_2 - 8e-23 80.8 2.3 1.4e-22 80.0 2.3 1.4 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain Cullin PF00888.20 NM_001008895.2_1 - 2.5e-210 700.1 10.4 3.1e-210 699.7 10.4 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 NM_001008895.2_1 - 6.8e-24 83.5 0.3 1.9e-23 82.1 0.3 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain SecA_SW PF07516.11 NM_001008895.2_1 - 0.038 13.9 0.1 0.038 13.9 0.1 2.5 3 1 0 3 3 3 0 SecA Wing and Scaffold domain PX PF00787.22 NM_001267060.1_3 - 1e-08 35.0 0.6 2.8e-08 33.6 0.1 1.9 2 0 0 2 2 2 1 PX domain RA PF00788.21 NM_001267060.1_3 - 0.003 18.0 0.1 0.0061 17.0 0.1 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain FERM_M PF00373.16 NM_001267060.1_3 - 0.013 15.7 0.6 0.12 12.6 0.2 2.4 2 1 1 3 3 3 0 FERM central domain Nod1 PF17114.3 NM_001267060.1_3 - 0.02 14.9 0.4 0.039 14.0 0.4 1.4 1 0 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 Ras_bdg_2 PF14847.4 NM_001267060.1_3 - 0.026 14.7 0.0 0.045 13.9 0.0 1.3 1 0 0 1 1 1 0 Ras-binding domain of Byr2 Ldl_recept_a PF00057.16 NM_004525.2_1 - 0 1106.1 655.1 2.8e-12 46.5 10.6 37.2 36 0 0 36 36 36 36 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 NM_004525.2_1 - 2.3e-208 674.3 77.6 2.9e-14 53.1 0.0 37.0 38 0 0 38 38 38 30 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 NM_004525.2_1 - 1.7e-69 229.7 311.4 3.3e-09 36.8 6.2 24.2 22 1 0 22 22 22 16 Coagulation Factor Xa inhibitory site cEGF PF12662.5 NM_004525.2_1 - 5.8e-29 99.5 128.6 2.5e-10 39.9 1.1 18.4 18 0 0 18 18 18 10 Complement Clr-like EGF-like DUF5050 PF16472.3 NM_004525.2_1 - 4.2e-28 98.3 0.0 0.0001 21.5 0.0 9.6 8 2 0 9 9 9 6 Domain of unknown function (DUF5050) EGF_CA PF07645.13 NM_004525.2_1 - 2.1e-16 59.7 36.4 8.6e-09 35.3 4.8 35.8 27 10 11 40 40 40 5 Calcium-binding EGF domain SGL PF08450.10 NM_004525.2_1 - 1.4e-12 47.6 24.8 0.49 9.8 0.3 14.8 10 6 4 15 15 15 4 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.18 NM_004525.2_1 - 1.7e-06 28.0 1.6 59 3.8 0.0 9.4 11 1 1 12 12 12 0 Arylesterase Pkinase PF00069.23 NM_001271977.1_3 - 8.3e-70 235.0 0.0 1e-69 234.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001271977.1_3 - 3.6e-51 173.8 0.0 5.5e-51 173.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1241 PF06840.9 NM_001271977.1_3 - 0.00042 19.8 0.0 0.00079 19.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Kinase-like PF14531.4 NM_001271977.1_3 - 0.019 14.1 0.0 0.053 12.7 0.0 1.6 2 0 0 2 2 2 0 Kinase-like SRR1 PF07985.10 NM_001013694.2_2 - 2.4e-16 59.4 0.2 4e-16 58.7 0.2 1.4 1 0 0 1 1 1 1 SRR1 Ras PF00071.20 NM_001204883.1_2 - 5.5e-56 188.5 0.2 7.1e-56 188.1 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001204883.1_2 - 1.4e-33 115.6 0.1 1.9e-33 115.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001204883.1_2 - 2.2e-12 46.6 0.0 3.3e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_001204883.1_2 - 0.044 13.0 0.0 0.065 12.4 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.8 NM_001204883.1_2 - 0.14 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.25 NM_001204883.1_2 - 0.23 10.9 0.0 0.34 10.3 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain UBA PF00627.29 NM_001171203.2_3 - 0.0068 16.2 0.2 0.19 11.6 0.0 2.9 3 0 0 3 3 3 1 UBA/TS-N domain MerR-DNA-bind PF09278.9 NM_001171203.2_3 - 0.11 12.9 0.1 0.4 11.1 0.1 1.9 2 0 0 2 2 2 0 MerR, DNA binding VGLL4 PF15245.4 NM_001128219.2_1 - 1.9e-99 332.0 1.1 2.9e-99 331.4 1.1 1.3 1 0 0 1 1 1 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.12 NM_001128219.2_1 - 0.00081 18.9 0.0 1.2 8.8 0.0 2.5 2 0 0 2 2 2 2 Vestigial/Tondu family zf-C3HC PF07967.11 NM_001282191.1_2 - 5.7e-35 120.1 8.0 6.4e-35 119.9 0.1 2.8 2 1 0 2 2 2 1 C3HC zinc finger-like Rsm1 PF08600.8 NM_001282191.1_2 - 1.7e-15 56.8 8.1 1.5e-10 40.9 0.4 3.0 2 1 1 3 3 3 2 Rsm1-like Yippee-Mis18 PF03226.12 NM_001282191.1_2 - 0.041 14.0 4.1 0.41 10.7 0.1 2.4 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2575 PF10837.6 NM_001282191.1_3 - 0.12 12.5 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Cbl_N PF02262.14 NM_005188.3_2 - 4.5e-55 184.9 0.7 7e-55 184.3 0.7 1.3 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N3 PF02762.12 NM_005188.3_2 - 2.6e-44 148.8 0.0 4.8e-44 148.0 0.0 1.5 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N2 PF02761.12 NM_005188.3_2 - 1.7e-40 137.5 0.8 3e-40 136.7 0.8 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Prok-RING_4 PF14447.4 NM_005188.3_2 - 1.3e-12 47.2 9.4 4.8e-12 45.4 9.4 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 NM_005188.3_2 - 4.6e-10 39.1 8.4 4.6e-10 39.1 8.4 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_005188.3_2 - 1.1e-08 34.7 8.2 5.3e-08 32.5 8.2 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_005188.3_2 - 5e-07 29.7 8.0 5e-07 29.7 8.0 3.4 2 0 0 2 2 2 1 Ring finger domain UBA PF00627.29 NM_005188.3_2 - 4.5e-05 23.1 0.1 7.5e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain zf-RING_5 PF14634.4 NM_005188.3_2 - 1.9 8.4 18.1 0.07 13.0 10.6 2.7 2 0 0 2 2 2 0 zinc-RING finger domain RepA1_leader PF08048.10 NM_005188.3_3 - 1.6 8.9 5.2 7.8 6.7 5.2 2.3 1 0 0 1 1 1 0 Tap RepA1 leader peptide TMEM154 PF15102.4 NM_001030288.2_1 - 0.026 14.3 0.0 0.026 14.3 0.0 1.8 2 0 0 2 2 2 0 TMEM154 protein family NADH_Oxid_Nqo15 PF11497.6 NM_001030288.2_1 - 0.21 11.5 0.6 0.42 10.5 0.6 1.4 1 0 0 1 1 1 0 NADH-quinone oxidoreductase chain 15 INSIG PF07281.10 NM_005542.4_2 - 4.9e-46 156.9 7.4 1.6e-45 155.3 7.4 1.8 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) NDK PF00334.17 NM_001018138.1_2 - 1.3e-55 186.9 0.0 1.6e-55 186.6 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Casc1 PF12366.6 NM_001018138.1_3 - 0.034 13.5 1.1 0.043 13.2 1.1 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 V-set PF07686.15 NM_024626.3_1 - 2.4e-09 37.2 0.0 1e-08 35.1 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_024626.3_1 - 1.3e-08 35.2 0.4 0.00015 22.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_024626.3_1 - 6.1e-07 29.3 0.7 0.0045 16.9 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_024626.3_1 - 6.6e-06 26.2 0.0 0.01 16.0 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_024626.3_1 - 0.001 19.0 0.6 0.0091 16.0 0.0 2.7 2 2 0 2 2 2 1 Immunoglobulin domain Pentaxin PF00354.15 NM_002523.2_1 - 5.4e-33 114.2 0.0 7.4e-33 113.7 0.0 1.2 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 NM_002523.2_1 - 5.4e-14 52.5 0.0 8.2e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily GrpE PF01025.17 NM_002523.2_1 - 0.014 14.9 1.1 0.027 14.0 1.1 1.4 1 0 0 1 1 1 0 GrpE GOLGA2L5 PF15070.4 NM_002523.2_1 - 0.016 13.8 6.6 0.022 13.3 6.6 1.1 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 SlyX PF04102.10 NM_002523.2_1 - 0.21 12.1 8.0 4.8 7.7 0.1 3.6 3 1 0 3 3 3 0 SlyX HalX PF08663.8 NM_002523.2_1 - 0.31 11.2 1.7 2 8.6 0.0 2.4 1 1 1 2 2 2 0 HalX domain CLZ PF16526.3 NM_002523.2_1 - 1 9.6 8.2 10 6.4 0.0 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HOOK PF05622.10 NM_002523.2_1 - 1.1 7.1 6.1 0.61 8.0 3.2 1.7 2 0 0 2 2 2 0 HOOK protein JIP_LZII PF16471.3 NM_002523.2_1 - 1.6 8.8 7.8 0.93 9.6 2.4 2.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II CorA PF01544.16 NM_002523.2_1 - 1.9 7.6 5.8 0.79 8.8 2.7 1.7 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein ABC_tran_CTD PF16326.3 NM_002523.2_1 - 4.3 7.5 7.2 5.7 7.1 1.2 2.5 1 1 1 2 2 2 0 ABC transporter C-terminal domain Pkinase PF00069.23 NM_001324327.1_2 - 1.2e-71 241.0 0.0 2e-71 240.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001324327.1_2 - 1.2e-44 152.4 0.0 2.1e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 NM_001324327.1_2 - 7.3e-19 67.8 0.0 1.6e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 NM_001324327.1_2 - 1.2e-05 24.7 0.0 0.0025 17.1 0.0 2.4 1 1 1 2 2 2 2 Kinase-like Ribosomal_60s PF00428.17 NM_001324327.1_2 - 0.11 12.9 2.4 0.27 11.7 2.4 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein DSHCT PF08148.10 NM_001324327.1_2 - 0.14 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain APH PF01636.21 NM_001324327.1_2 - 0.15 11.8 0.1 0.44 10.3 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Spt5_N PF11942.6 NM_001324327.1_2 - 9.2 7.2 11.1 0.041 14.7 1.9 1.7 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal HSP90 PF00183.16 NM_005348.3_2 - 1e-242 806.5 34.3 1.3e-242 806.1 34.3 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.24 NM_005348.3_2 - 4.7e-14 52.8 0.1 1.1e-13 51.6 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 NM_005348.3_2 - 5.6e-12 45.5 0.1 1.4e-11 44.3 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Zip PF02535.20 NM_005348.3_2 - 0.17 10.9 0.8 0.34 9.9 0.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.12 NM_005348.3_2 - 4 5.5 16.0 7.4 4.6 16.0 1.3 1 0 0 1 1 1 0 CDC45-like protein TPP1 PF10341.7 NM_022914.2_2 - 1.3e-17 63.6 0.0 2e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD E2F_TDP PF02319.18 NM_024680.3_1 - 1.1e-41 140.5 0.3 4e-20 71.5 0.0 2.4 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.17 NM_024680.3_1 - 0.00044 19.9 0.0 0.0012 18.5 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB UPF0122 PF04297.12 NM_024680.3_1 - 0.028 14.5 0.1 0.062 13.4 0.1 1.6 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like WD40 PF00400.30 NM_145054.4_1 - 5.5e-32 109.2 13.0 0.0085 16.8 0.0 11.2 11 1 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_145054.4_1 - 9.1e-06 25.8 0.9 1.1 9.4 0.0 5.9 5 2 1 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_145054.4_1 - 0.005 16.1 0.3 4.6 6.3 0.0 3.9 3 1 1 5 5 5 2 WD40-like domain BPL_LplA_LipB PF03099.17 NM_001242785.1_1 - 2.5e-29 101.7 0.0 4.8e-29 100.8 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.15 NM_001242785.1_1 - 1.6e-10 40.6 0.2 3.2e-10 39.6 0.2 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain BPL_N PF09825.7 NM_001242785.1_1 - 7.3e-10 38.3 0.0 4.7e-06 25.8 0.0 2.2 2 0 0 2 2 2 2 Biotin-protein ligase, N terminal SCAN PF02023.15 NM_013250.2_1 - 3.4e-37 126.0 3.0 6e-37 125.2 3.0 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 NM_013250.2_1 - 9.2e-24 82.4 35.2 3.4e-06 27.1 0.7 6.3 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_013250.2_1 - 4.6e-21 74.1 35.3 2.3e-07 30.8 0.7 7.2 6 0 0 6 6 6 4 Zinc-finger double domain KRAB PF01352.25 NM_013250.2_1 - 9.5e-21 73.1 0.4 2.2e-20 71.9 0.4 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_013250.2_1 - 8.9e-10 38.4 35.0 0.027 15.2 0.5 6.7 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_013250.2_1 - 0.0022 18.1 18.5 0.045 13.9 0.9 4.7 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_013250.2_1 - 0.019 14.6 22.2 0.15 11.7 1.3 4.2 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 NM_013250.2_1 - 0.022 14.6 0.7 0.022 14.6 0.7 5.7 8 0 0 8 8 8 0 C2H2-type zinc finger C1_4 PF07975.10 NM_013250.2_1 - 0.23 11.6 18.2 0.68 10.1 1.6 3.8 1 1 1 3 3 3 0 TFIIH C1-like domain ADK_lid PF05191.12 NM_013250.2_1 - 0.25 11.3 6.6 7.7 6.5 0.7 3.2 2 0 0 2 2 2 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 NM_013250.2_1 - 1.2 9.2 21.5 0.11 12.5 1.2 4.0 3 1 1 4 4 4 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.5 NM_013250.2_1 - 5.1 7.0 16.0 0.57 10.1 1.0 3.3 2 1 1 3 3 3 0 Transposase zinc-ribbon domain DUF4529 PF15032.4 NM_152337.2_2 - 1.8e-205 682.7 3.9 2.1e-205 682.4 3.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4529) Sen15 PF09631.8 NM_001127394.3_1 - 2.6e-07 30.7 0.0 4.5e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Sen15 protein BrnA_antitoxin PF14384.4 NM_001127394.3_1 - 0.19 12.1 0.0 0.32 11.4 0.0 1.3 1 0 0 1 1 1 0 BrnA antitoxin of type II toxin-antitoxin system bZIP_1 PF00170.19 NM_005171.4_3 - 9.4e-21 73.6 10.5 1.5e-20 72.9 10.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.15 NM_005171.4_3 - 3.2e-18 64.8 2.0 7.8e-18 63.5 2.0 1.7 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.13 NM_005171.4_3 - 2.3e-08 33.9 8.1 3.9e-08 33.1 8.1 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_005171.4_3 - 0.00073 19.9 5.2 0.0014 18.9 5.2 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor ASD2 PF08687.9 NM_005171.4_3 - 1.2 8.6 7.7 0.092 12.2 3.1 1.4 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Promethin PF16015.3 NM_001301769.1_2 - 2.5e-22 78.7 14.5 6.7e-22 77.3 14.5 1.8 1 0 0 1 1 1 1 Promethin DUF2207 PF09972.7 NM_001301769.1_2 - 0.24 10.0 0.7 0.37 9.4 0.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PHD_4 PF16866.3 NM_001005366.1_3 - 4.5e-26 90.6 9.1 4.5e-26 90.6 9.1 2.4 2 0 0 2 2 2 1 PHD-finger zf-CXXC PF02008.18 NM_001005366.1_3 - 2.3e-14 53.0 21.5 2.3e-14 53.0 21.5 3.0 2 0 0 2 2 2 1 CXXC zinc finger domain F-box PF00646.31 NM_001005366.1_3 - 5.7e-12 45.1 1.9 5.7e-12 45.1 1.9 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.5 NM_001005366.1_3 - 4.7e-09 35.9 6.8 1.1e-08 34.7 6.8 1.7 1 0 0 1 1 1 1 F-box-like Cupin_8 PF13621.4 NM_001005366.1_3 - 9e-07 28.8 0.0 4e-06 26.7 0.0 1.9 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.20 NM_001005366.1_3 - 5.1e-06 26.8 0.3 9e-05 22.8 0.3 2.7 1 1 0 1 1 1 1 JmjC domain, hydroxylase LRR_6 PF13516.4 NM_001005366.1_3 - 0.024 14.6 7.3 48 4.2 0.3 6.5 7 0 0 7 7 7 0 Leucine Rich repeat LRR_8 PF13855.4 NM_001005366.1_3 - 0.051 13.2 2.7 23 4.7 0.0 3.9 4 0 0 4 4 4 0 Leucine rich repeat CRAL_TRIO PF00650.18 NM_001039199.2_2 - 2.9e-32 111.4 0.0 4.5e-32 110.8 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.13 NM_001039199.2_2 - 6.8e-07 29.2 0.8 1.4e-06 28.3 0.8 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.4 NM_001039199.2_2 - 4.3e-06 26.7 0.0 8.8e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SAM_1 PF00536.28 NM_001198916.1_3 - 7.1e-38 128.7 10.4 4.8e-17 62.0 0.2 3.9 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001198916.1_3 - 2.2e-32 110.8 5.8 8.4e-14 51.3 0.0 3.9 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) DUF16 PF01519.14 NM_001198916.1_3 - 0.0011 19.3 1.3 0.0011 19.3 1.3 2.9 2 1 0 2 2 2 1 Protein of unknown function DUF16 SAM_PNT PF02198.14 NM_001198916.1_3 - 0.03 14.2 2.2 3.3 7.6 0.1 3.1 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain ADIP PF11559.6 NM_001198916.1_3 - 0.36 10.8 23.2 0.18 11.8 8.8 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.4 NM_001198916.1_3 - 0.46 9.7 14.1 7.1 5.8 12.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Reo_sigmaC PF04582.10 NM_001198916.1_3 - 5.8 6.1 7.4 8.5 5.5 1.3 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF3837 PF12939.5 NM_001198916.1_3 - 7.5 6.9 12.3 0.037 14.3 1.0 2.9 3 1 1 4 4 4 0 Domain of unknown function (DUF3837) Fez1 PF06818.13 NM_015209.2_3 - 2.9e-05 24.5 13.4 0.0014 19.0 9.1 2.4 2 0 0 2 2 2 2 Fez1 DUF148 PF02520.15 NM_015209.2_3 - 0.028 14.4 5.9 0.067 13.2 5.9 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF148 DUF812 PF05667.9 NM_015209.2_3 - 2.2 6.9 20.4 4.2 6.0 20.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF812) TPR_MLP1_2 PF07926.10 NM_015209.2_3 - 4.2 7.3 41.9 0.11 12.4 22.3 3.6 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF1192 PF06698.9 NM_015209.2_3 - 5 7.1 11.3 1.1 9.2 2.5 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Abhydrolase_6 PF12697.5 NM_016147.2_3 - 2.1e-25 90.5 0.0 6.7e-25 88.8 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 NM_016147.2_3 - 2.8e-12 46.7 0.0 4.3e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 NM_016147.2_3 - 1.6e-07 30.7 0.0 2.6e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.18 NM_016147.2_3 - 0.00012 22.1 0.0 0.00021 21.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_3 PF07859.11 NM_016147.2_3 - 0.012 15.4 0.1 0.02 14.6 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.11 NM_016147.2_3 - 0.012 15.2 0.1 0.02 14.5 0.1 1.2 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.18 NM_016147.2_3 - 0.018 14.6 0.1 0.045 13.3 0.1 1.5 1 1 0 1 1 1 0 Putative esterase Lipase_3 PF01764.23 NM_016147.2_3 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_2 PF02230.14 NM_016147.2_3 - 0.12 12.0 0.7 11 5.5 0.1 2.3 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Ras PF00071.20 NM_001304839.1_3 - 2.2e-35 121.5 0.1 3.2e-35 121.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001304839.1_3 - 8.1e-26 90.5 0.0 1.2e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001304839.1_3 - 3.1e-13 49.4 0.0 4.7e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_001304839.1_3 - 0.00049 19.4 0.0 0.00067 19.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 NM_001304839.1_3 - 0.0023 17.3 0.0 0.01 15.2 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 NM_001304839.1_3 - 0.0036 16.6 0.0 0.006 15.9 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 NM_001304839.1_3 - 0.035 14.0 0.0 0.052 13.5 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase VirE PF05272.9 NM_001304839.1_3 - 0.16 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Virulence-associated protein E IQ PF00612.25 NM_006176.2_3 - 3e-05 23.3 0.7 6.6e-05 22.2 0.7 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif RCC1 PF00415.16 NM_001278185.1_3 - 2.8e-89 293.4 18.3 1.8e-14 54.0 0.0 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat HECT PF00632.23 NM_001278185.1_3 - 2.4e-63 214.3 0.1 2.9e-62 210.8 0.1 2.3 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RCC1_2 PF13540.4 NM_001278185.1_3 - 4.8e-45 150.4 33.7 6.1e-11 41.7 0.4 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat MAP7 PF05672.9 NM_001198608.1_1 - 7.9e-41 139.4 83.3 7.9e-41 139.4 83.3 2.9 2 1 1 3 3 3 1 MAP7 (E-MAP-115) family PH_5 PF15405.4 NM_001198608.1_1 - 0.0056 16.6 0.2 0.018 15.0 0.2 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain 7tm_1 PF00001.19 NM_153832.2_3 - 4.2e-44 150.7 17.9 8e-44 149.7 17.9 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 NM_153832.2_3 - 0.0009 18.5 14.3 0.0016 17.7 14.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Ras PF00071.20 NM_001206836.1_2 - 6.4e-52 175.3 0.1 9.2e-52 174.8 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001206836.1_2 - 8.6e-34 116.2 0.1 1.2e-33 115.7 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001206836.1_2 - 1.5e-10 40.7 0.1 2.4e-10 40.0 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001206836.1_2 - 6.8e-06 26.0 0.1 1e-05 25.4 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 NM_001206836.1_2 - 0.0046 17.1 0.0 0.014 15.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.25 NM_001206836.1_2 - 0.057 12.8 0.0 0.094 12.1 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF258 PF03193.14 NM_001206836.1_2 - 0.077 12.8 0.1 0.22 11.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Myotub-related PF06602.12 NM_021090.3_2 - 5.8e-140 466.0 0.0 8e-140 465.5 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain FYVE PF01363.19 NM_021090.3_2 - 8.2e-18 64.2 12.2 8.2e-18 64.2 12.2 2.6 3 0 0 3 3 3 1 FYVE zinc finger Y_phosphatase PF00102.25 NM_021090.3_2 - 0.0015 18.1 0.0 0.0025 17.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 NM_021090.3_2 - 0.008 16.0 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 NM_021090.3_2 - 0.0089 15.7 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Cyclin_N PF00134.21 NM_033031.2_1 - 2.7e-38 130.5 8.7 4.1e-37 126.7 3.7 2.6 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.17 NM_033031.2_1 - 4.9e-24 84.6 3.0 1.8e-23 82.7 3.0 2.1 1 0 0 1 1 1 1 Cyclin, C-terminal domain Dicty_spore_N PF04562.10 NM_033031.2_1 - 0.55 10.8 5.0 2.1 8.9 5.0 2.0 1 0 0 1 1 1 0 Dictyostelium spore coat protein, N terminus STIL_N PF15253.4 NM_001282939.1_2 - 5.1e-177 588.7 0.8 3.3e-113 378.6 0.4 2.4 1 1 1 2 2 2 2 SCL-interrupting locus protein N-terminus Pribosyl_synth PF14572.4 NM_002766.2_3 - 3.6e-99 330.2 1.0 5.7e-99 329.5 1.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.4 NM_002766.2_3 - 3e-38 130.2 0.2 5.6e-38 129.3 0.2 1.4 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.25 NM_002766.2_3 - 3.8e-06 26.4 0.1 8.2e-06 25.3 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF938 PF06080.10 NM_001040165.2_2 - 4e-42 144.2 0.0 5.1e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_25 PF13649.4 NM_001040165.2_2 - 0.0007 20.1 0.0 0.0012 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 NM_001040165.2_2 - 0.011 15.4 0.0 0.015 14.9 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.12 NM_001040165.2_2 - 0.012 15.0 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.15 NM_001040165.2_2 - 0.04 13.2 0.0 0.057 12.7 0.0 1.1 1 0 0 1 1 1 0 Putative methyltransferase RskA PF10099.7 NM_001040165.2_2 - 0.086 13.0 7.8 0.18 11.9 7.6 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF938 PF06080.10 NM_001040165.2_3 - 6.6e-13 48.7 0.0 9.5e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) PRELI PF04707.12 NM_001144001.1_1 - 3.4e-51 173.0 0.2 5.2e-51 172.4 0.2 1.2 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.18 NM_001144001.1_1 - 4e-39 133.8 0.0 5.9e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.13 NM_001144001.1_1 - 4e-05 23.6 0.1 8.5e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain UvrD_C PF13361.4 NM_001258453.1_2 - 1.3e-13 51.0 0.1 2.4e-13 50.1 0.1 1.4 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.4 NM_001258453.1_2 - 5.7e-12 46.1 0.0 1e-11 45.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.19 NM_001258453.1_2 - 1.1e-11 44.7 0.1 1.6e-07 31.1 0.0 2.5 2 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.4 NM_001258453.1_2 - 2.1e-11 43.3 0.4 2.5e-10 39.9 0.4 2.6 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain F-box-like PF12937.5 NM_001258453.1_2 - 7.6e-09 35.2 3.1 2.9e-08 33.3 3.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 NM_001258453.1_2 - 5.8e-08 32.3 3.5 5.8e-08 32.3 3.5 2.3 3 0 0 3 3 3 1 F-box domain Viral_helicase1 PF01443.16 NM_001258453.1_2 - 1e-05 25.2 0.2 0.19 11.3 0.0 3.7 3 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.4 NM_001258453.1_2 - 1.5e-05 24.6 0.0 0.012 15.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain ResIII PF04851.13 NM_001258453.1_2 - 0.001 19.0 0.8 0.0022 17.9 0.8 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.14 NM_001258453.1_2 - 0.0024 17.2 0.0 1.3 8.3 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein AAA_12 PF13087.4 NM_001258453.1_2 - 0.027 14.0 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain F-box_4 PF15966.3 NM_001258453.1_2 - 0.054 13.2 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 F-box AAA_11 PF13086.4 NM_001258453.1_2 - 0.14 11.7 0.1 3.2 7.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain BBIP10 PF14777.4 NM_001195306.1_2 - 7.7e-30 102.1 5.3 1.2e-29 101.5 5.3 1.3 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 tRNA-synt_1e PF01406.17 NM_024537.3_1 - 8.3e-111 370.0 0.5 1.8e-110 368.9 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.9 NM_024537.3_1 - 1.4e-13 50.3 0.1 9.8e-06 24.5 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.20 NM_024537.3_1 - 0.0001 20.6 0.0 0.00018 19.7 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.16 NM_024537.3_1 - 0.00016 20.6 0.2 0.0011 17.8 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (K) IFRD PF05004.11 NM_001197079.1_1 - 1.3e-111 372.4 4.2 1.6e-111 372.1 4.2 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.10 NM_001197079.1_1 - 3.2e-24 85.1 0.6 7.4e-24 84.0 0.6 1.7 1 0 0 1 1 1 1 Interferon-related protein conserved region C2 PF00168.28 NM_001100117.2_2 - 7.1e-37 125.7 0.0 4.2e-19 68.6 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 NM_001100117.2_2 - 5e-15 55.6 13.2 1.1e-14 54.5 13.2 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger PDZ PF00595.22 NM_001100117.2_2 - 1.1e-05 25.6 0.0 2.1e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PLA2_B PF01735.16 NM_001206670.1_1 - 5.7e-34 117.2 0.0 1.2e-33 116.2 0.0 1.4 2 0 0 2 2 2 1 Lysophospholipase catalytic domain C2 PF00168.28 NM_001206670.1_1 - 6e-17 61.7 0.3 1.1e-16 60.9 0.3 1.4 1 0 0 1 1 1 1 C2 domain PI3_PI4_kinase PF00454.25 NM_001288772.1_3 - 5.2e-51 173.7 1.4 1.5e-49 168.9 1.4 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.18 NM_001288772.1_3 - 5.5e-31 107.3 4.3 5.5e-31 107.3 4.3 2.3 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PX PF00787.22 NM_001288772.1_3 - 1.7e-15 56.8 5.4 2.4e-15 56.4 3.3 2.4 2 0 0 2 2 2 1 PX domain PI3K_C2 PF00792.22 NM_001288772.1_3 - 7.9e-11 42.0 0.3 2e-10 40.8 0.3 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.16 NM_001288772.1_3 - 3.8e-09 36.5 0.3 9.6e-09 35.2 0.3 1.7 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain C2 PF00168.28 NM_001288772.1_3 - 1.6e-07 31.4 0.1 9.3e-06 25.7 0.0 2.6 2 0 0 2 2 2 1 C2 domain DUF4135 PF13575.4 NM_001288772.1_3 - 0.00025 20.3 0.0 0.00043 19.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) Serum_albumin PF00273.18 NM_001288772.1_3 - 0.045 13.4 2.1 0.089 12.4 0.5 2.3 2 0 0 2 2 2 0 Serum albumin family Defensin_beta PF00711.17 NM_001033018.2_1 - 0.00068 19.5 7.9 0.001 18.9 7.9 1.3 1 0 0 1 1 1 1 Beta defensin NUDIX PF00293.26 NM_001243657.1_2 - 7.9e-09 35.5 0.0 1.2e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Lectin_C PF00059.19 NM_001255989.1_3 - 1.9e-15 57.3 0.0 4e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 NM_001255989.1_3 - 0.002 17.7 1.2 0.004 16.7 1.2 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) S_100 PF01023.17 NM_005980.2_2 - 3.8e-19 68.0 0.0 7e-19 67.1 0.0 1.5 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 NM_005980.2_2 - 5.9e-06 26.5 0.1 1.3e-05 25.4 0.1 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_005980.2_2 - 0.00039 19.6 0.6 0.0021 17.3 0.2 2.2 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 NM_005980.2_2 - 0.00097 18.7 0.2 0.0017 17.9 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.5 NM_005980.2_2 - 0.12 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SIR2 PF02146.15 NM_001321061.1_1 - 6.1e-14 52.2 0.0 6.4e-12 45.6 0.0 2.1 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.20 NM_001321061.1_1 - 0.0023 17.6 0.0 0.0033 17.0 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain RNA_pol_Rpb4 PF03874.14 NM_001040648.1_2 - 4e-10 39.9 0.4 6e-10 39.4 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 Muted PF14942.4 NM_001040648.1_2 - 0.0042 17.3 1.3 0.012 15.8 1.3 1.7 1 1 0 1 1 1 1 Organelle biogenesis, Muted-like protein PMP22_Claudin PF00822.18 NM_001002026.2_3 - 7.8e-28 97.3 14.8 1.8e-27 96.1 14.8 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001002026.2_3 - 1e-07 31.8 17.0 1.9e-06 27.6 17.0 2.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction zf-H2C2_2 PF13465.4 NM_001320670.1_2 - 1.7e-84 274.6 109.8 2e-08 34.1 0.4 14.8 15 0 0 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001320670.1_2 - 3.7e-53 175.0 106.5 9.1e-05 22.6 3.6 14.4 14 0 0 14 14 14 12 Zinc finger, C2H2 type KRAB PF01352.25 NM_001320670.1_2 - 3.9e-24 83.9 0.7 7.3e-24 83.0 0.7 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001320670.1_2 - 5.2e-24 82.7 102.1 0.027 15.1 0.9 14.6 14 0 0 14 14 14 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001320670.1_2 - 3e-16 58.8 87.0 0.025 14.4 0.9 13.9 14 0 0 14 14 14 12 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001320670.1_2 - 1.1e-10 41.3 81.0 0.0042 17.0 3.7 9.6 2 1 8 11 11 11 9 Zinc ribbon domain C1_4 PF07975.10 NM_001320670.1_2 - 0.00019 21.5 62.9 0.53 10.5 7.1 9.6 3 2 8 11 11 11 3 TFIIH C1-like domain DUF3268 PF11672.6 NM_001320670.1_2 - 0.43 10.8 43.8 2.8 8.2 2.2 7.1 5 1 3 8 8 8 0 zinc-finger-containing domain XPA_N PF01286.16 NM_001320670.1_2 - 1.2 9.1 75.9 12 5.9 0.1 14.2 14 0 0 14 14 14 0 XPA protein N-terminal Baculo_LEF-11 PF06385.10 NM_001320670.1_3 - 0.1 13.0 12.7 20 5.7 0.0 5.3 4 1 0 5 5 5 0 Baculovirus LEF-11 protein IF-2B PF01008.15 NM_001318969.1_1 - 1.2e-90 303.4 0.0 1.5e-90 303.1 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Mating_C PF12737.5 NM_001318969.1_3 - 0.76 8.8 6.7 1.3 8.1 6.7 1.3 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 zf-H2C2_2 PF13465.4 NM_001185118.1_2 - 1.7e-50 167.2 44.1 1.1e-08 35.0 0.9 9.4 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001185118.1_2 - 6.5e-34 114.4 55.8 2.9e-05 24.1 0.7 9.1 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001185118.1_2 - 3.4e-27 92.6 53.2 0.00093 19.7 0.2 9.2 8 0 0 8 8 8 8 C2H2-type zinc finger BTB PF00651.29 NM_001185118.1_2 - 1.4e-24 86.3 0.2 2.8e-24 85.4 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_6 PF13912.4 NM_001185118.1_2 - 9.9e-13 47.6 36.1 0.048 13.5 0.1 8.7 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001185118.1_2 - 5e-10 39.3 25.3 0.029 14.6 0.1 8.3 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001185118.1_2 - 0.00048 20.3 51.9 0.017 15.4 0.3 8.6 9 0 0 9 9 8 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 NM_001185118.1_2 - 0.004 16.8 38.9 0.24 11.1 0.5 8.9 9 0 0 9 9 9 2 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.3 NM_001185118.1_2 - 0.004 16.8 0.5 0.004 16.8 0.5 7.9 8 0 0 8 8 8 2 zinc-finger C2H2-type zf-Di19 PF05605.10 NM_001185118.1_2 - 0.048 13.8 30.1 0.64 10.2 0.3 4.8 3 1 2 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.3 NM_001185118.1_2 - 0.25 12.0 22.9 1.9 9.1 1.9 5.0 1 1 5 6 6 6 0 zinc-ribbon family zf-C2H2_8 PF15909.3 NM_001185118.1_2 - 0.37 11.0 19.3 0.24 11.6 6.1 3.9 1 1 2 4 4 4 0 C2H2-type zinc ribbon DUF3268 PF11672.6 NM_001185118.1_2 - 0.75 10.0 19.3 1.4 9.2 0.7 4.0 2 1 1 4 4 4 0 zinc-finger-containing domain Zn-ribbon_8 PF09723.8 NM_001185118.1_2 - 2.7 8.1 27.8 1.4 9.0 1.5 6.2 1 1 7 8 8 8 0 Zinc ribbon domain ADK_lid PF05191.12 NM_001185118.1_2 - 4.6 7.2 25.6 16 5.5 1.1 6.1 3 3 2 6 6 6 0 Adenylate kinase, active site lid SH3_1 PF00018.26 NM_001128923.1_2 - 8.8e-57 188.4 0.7 1.9e-14 52.9 0.0 4.7 4 0 0 4 4 4 4 SH3 domain SH3_9 PF14604.4 NM_001128923.1_2 - 4.2e-51 170.5 1.0 6e-14 51.5 0.0 5.4 5 0 0 5 5 5 5 Variant SH3 domain SH3_2 PF07653.15 NM_001128923.1_2 - 3.5e-40 135.4 0.3 1.7e-09 37.1 0.2 5.4 5 0 0 5 5 5 4 Variant SH3 domain Ets PF00178.20 NM_016135.3_2 - 1e-27 96.3 0.8 1.8e-27 95.5 0.8 1.4 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 NM_016135.3_2 - 3.3e-23 81.3 0.0 6.1e-23 80.5 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain His_Phos_2 PF00328.20 NM_001302491.1_2 - 1.2e-27 97.1 1.5 2.6e-17 63.1 0.2 3.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) zf-H2C2_2 PF13465.4 NM_001286053.1_3 - 5e-131 421.7 150.2 4.1e-09 36.4 1.3 19.8 20 0 0 20 20 19 17 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001286053.1_3 - 7.9e-88 284.2 124.9 2.1e-06 27.8 0.4 19.1 19 0 0 19 19 18 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001286053.1_3 - 7.5e-44 144.5 117.8 0.0074 16.9 1.4 18.8 18 0 0 18 18 18 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001286053.1_3 - 3.3e-43 144.8 105.9 8e-05 22.4 0.6 19.0 18 0 0 18 18 18 16 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001286053.1_3 - 4.7e-25 86.9 63.1 0.0029 17.2 0.1 17.9 19 0 0 19 19 18 10 zinc-finger C2H2-type XPA_N PF01286.16 NM_001286053.1_3 - 2.7e-23 81.6 80.6 0.89 9.5 0.1 17.7 18 0 0 18 18 17 14 XPA protein N-terminal Zn-ribbon_8 PF09723.8 NM_001286053.1_3 - 1.7e-18 66.3 106.5 0.0021 18.0 2.9 13.4 5 3 13 18 18 17 14 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001286053.1_3 - 4.5e-18 65.0 76.6 0.32 11.2 0.0 17.6 18 0 0 18 18 17 8 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 NM_001286053.1_3 - 7.8e-12 44.8 85.9 0.0025 17.5 2.8 16.1 14 4 0 14 14 14 4 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 NM_001286053.1_3 - 1.7e-09 38.2 85.0 0.3 11.7 1.4 9.5 4 1 2 9 9 9 8 zinc-ribbon family FAM178 PF14816.4 NM_001286053.1_3 - 5.7e-06 25.4 9.3 5.9 5.6 0.1 7.5 1 1 10 11 11 11 2 Family of unknown function, FAM178 ADK_lid PF05191.12 NM_001286053.1_3 - 1e-05 25.3 61.5 1.4 8.9 1.4 11.2 3 2 10 13 13 13 7 Adenylate kinase, active site lid C1_4 PF07975.10 NM_001286053.1_3 - 0.0081 16.3 88.5 0.14 12.3 1.7 13.4 2 1 17 19 19 19 5 TFIIH C1-like domain zf-RING_7 PF02591.13 NM_001286053.1_3 - 0.019 15.0 74.4 6 7.0 0.1 16.9 18 0 0 18 18 18 0 C4-type zinc ribbon domain MRP-S23 PF10484.7 NM_001286053.1_3 - 0.026 14.6 0.0 2e+02 2.0 0.0 5.6 3 2 0 5 5 5 0 Mitochondrial ribosomal protein S23 zf-AN1 PF01428.14 NM_001286053.1_3 - 0.03 14.4 94.6 11 6.1 1.5 18.5 15 2 3 18 18 18 0 AN1-like Zinc finger DUF3268 PF11672.6 NM_001286053.1_3 - 0.069 13.4 62.9 1.8 8.8 1.1 9.5 2 1 7 12 12 12 0 zinc-finger-containing domain PknG_rubred PF16919.3 NM_001286053.1_3 - 0.074 13.0 55.4 0.3 11.1 0.4 9.2 1 1 10 11 11 11 0 Protein kinase G rubredoxin domain GAGA PF09237.9 NM_001286053.1_3 - 0.27 10.9 0.1 0.27 10.9 0.1 7.2 6 3 4 10 10 10 0 GAGA factor YhfH PF14149.4 NM_001286053.1_3 - 2 8.3 84.0 15 5.5 0.3 17.2 17 0 0 17 17 17 0 YhfH-like protein TPR_1 PF00515.26 NM_006809.4_3 - 6.4e-26 88.9 10.2 5.2e-08 32.2 0.1 6.3 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.15 NM_006809.4_3 - 1.7e-21 74.4 9.7 2.6e-05 23.9 0.1 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.4 NM_006809.4_3 - 2.5e-10 40.4 5.7 0.017 15.3 0.7 5.3 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.4 NM_006809.4_3 - 1.3e-09 37.4 9.0 0.0058 16.2 0.2 4.4 4 0 0 4 4 4 3 TPR repeat TPR_8 PF13181.4 NM_006809.4_3 - 2.8e-07 30.1 11.2 0.019 15.0 0.2 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_006809.4_3 - 2.1e-05 25.0 0.5 0.044 14.4 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_006809.4_3 - 2.1e-05 24.3 3.6 0.00036 20.4 0.2 3.0 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.4 NM_006809.4_3 - 9.5e-05 22.7 1.0 0.027 14.9 0.1 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_006809.4_3 - 0.00019 21.4 12.0 0.022 14.8 5.7 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 NM_006809.4_3 - 0.00044 20.3 4.9 0.31 11.4 0.1 4.6 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_006809.4_3 - 0.0015 19.0 1.6 20 6.2 0.1 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_006809.4_3 - 0.029 14.1 4.8 1.4 8.8 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat PknG_TPR PF16918.3 NM_006809.4_3 - 0.045 12.4 0.0 0.077 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat MIT PF04212.16 NM_006809.4_3 - 0.057 13.4 9.4 6.8 6.7 0.1 4.8 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain DUF4919 PF16266.3 NM_006809.4_3 - 0.062 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4919) TPR_7 PF13176.4 NM_006809.4_3 - 0.068 13.1 6.0 33 4.7 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.7 NM_006809.4_3 - 0.35 10.2 5.0 5.2 6.5 0.1 4.4 6 0 0 6 6 6 0 SHNi-TPR TPR_6 PF13174.4 NM_006809.4_3 - 1.7 9.3 7.0 1.1e+02 3.6 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat E1_dh PF00676.18 NM_000284.3_2 - 2.1e-124 414.2 0.0 2.7e-124 413.8 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.4 NM_000284.3_2 - 0.0016 17.6 0.0 0.0025 17.0 0.0 1.2 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase bZIP_1 PF00170.19 NM_001130060.1_3 - 1.5e-11 44.0 7.9 1.5e-11 44.0 7.9 1.6 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001130060.1_3 - 4.6e-08 32.9 8.1 8.1e-08 32.1 8.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001130060.1_3 - 0.002 18.5 7.7 0.0037 17.6 7.7 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor zf-C2H2 PF00096.24 NM_001130060.1_3 - 0.0081 16.4 1.1 0.026 14.8 1.1 2.0 1 0 0 1 1 1 1 Zinc finger, C2H2 type Cnn_1N PF07989.9 NM_001130060.1_3 - 0.16 12.0 1.6 0.3 11.1 1.6 1.4 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Pkinase PF00069.23 NM_199347.3_2 - 1.2e-39 136.2 1.1 2.3e-39 135.2 1.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_199347.3_2 - 5.9e-27 94.5 0.2 1.1e-26 93.5 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_199347.3_2 - 1.2e-05 25.2 0.0 3.7e-05 23.6 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.20 NM_199347.3_2 - 5.8e-05 22.6 0.2 0.00011 21.7 0.2 1.5 1 0 0 1 1 1 1 RIO1 family Arm PF00514.21 NM_199347.3_2 - 0.056 13.4 7.7 1.7 8.7 0.1 4.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat MDFI PF15316.4 NM_001166345.1_3 - 2.9e-72 242.6 37.2 5.1e-72 241.8 37.2 1.4 1 0 0 1 1 1 1 MyoD family inhibitor Radical_SAM PF04055.19 NM_018264.3_1 - 1e-28 100.7 0.0 1.8e-28 99.8 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.10 NM_018264.3_1 - 1.1e-26 92.8 0.1 2.1e-26 91.9 0.1 1.5 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.23 NM_018264.3_1 - 4.1e-26 91.8 0.0 7.6e-26 90.9 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin EF-hand_4 PF12763.5 NM_007247.5_3 - 0.026 14.3 0.0 0.057 13.3 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Gpi1 PF05024.13 NM_148920.2_1 - 5.4e-66 222.2 7.5 8.3e-66 221.6 7.5 1.3 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Cyto_heme_lyase PF01265.15 NM_001122608.2_2 - 1.6e-70 237.8 7.8 4.1e-70 236.5 7.8 1.5 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase DZR PF12773.5 NM_001141979.1_1 - 0.085 12.8 1.9 0.7 9.8 0.4 2.6 2 0 0 2 2 2 0 Double zinc ribbon 53-BP1_Tudor PF09038.8 NM_001141979.1_3 - 2.4e-77 256.6 0.3 4.3e-77 255.8 0.3 1.4 1 0 0 1 1 1 1 Tumour suppressor p53-binding protein-1 Tudor BRCT PF00533.24 NM_001141979.1_3 - 0.0003 21.0 0.0 0.17 12.2 0.0 2.7 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 NM_001141979.1_3 - 0.0066 16.7 0.1 0.077 13.3 0.1 2.5 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.3 NM_001141979.1_3 - 0.01 15.6 0.0 0.058 13.1 0.0 2.4 3 0 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain DUF4537 PF15057.4 NM_001141979.1_3 - 0.028 14.3 0.0 0.069 13.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) DUF4772 PF15997.3 NM_001141979.1_3 - 0.083 13.3 2.7 6.9 7.1 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4772) DUF1272 PF06906.9 NM_001318897.1_1 - 0.34 10.9 9.9 0.055 13.4 5.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) LIM PF00412.20 NM_001318897.1_1 - 3.7 7.7 11.9 0.045 13.8 2.6 2.3 2 0 0 2 2 2 0 LIM domain LIM PF00412.20 NM_001318897.1_3 - 4.2e-29 100.4 37.2 2.4e-11 43.5 9.5 3.7 4 0 0 4 4 4 3 LIM domain zf-ribbon_3 PF13248.4 NM_001318897.1_3 - 0.1 11.9 0.2 0.1 11.9 0.2 4.0 4 0 0 4 4 4 0 zinc-ribbon domain VWA_N2 PF16164.3 NM_001318897.1_3 - 3.5 7.7 14.2 0.96 9.5 2.3 2.7 2 1 0 2 2 2 0 VWA N-terminal zf-H2C2_2 PF13465.4 NM_152412.2_3 - 9.1e-86 278.6 107.1 5e-09 36.1 0.6 14.5 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_152412.2_3 - 9.6e-67 217.8 117.4 2.3e-08 33.9 1.3 12.6 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_152412.2_3 - 3e-37 123.9 109.6 8.5e-05 22.9 1.0 12.9 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_152412.2_3 - 2.2e-14 52.9 91.2 0.001 18.8 0.9 12.8 12 0 0 12 12 12 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_152412.2_3 - 1.6e-09 37.6 60.5 0.0069 16.4 2.0 7.7 7 0 0 7 7 7 4 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_152412.2_3 - 1.6e-06 28.1 72.6 0.11 12.7 0.2 12.3 12 0 0 12 12 12 6 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_152412.2_3 - 0.0023 17.5 75.5 0.25 11.0 1.9 11.4 12 0 0 12 12 12 6 zinc-finger C2H2-type CpXC PF14353.4 NM_152412.2_3 - 0.049 13.5 36.1 6.6 6.7 1.1 8.8 9 2 0 9 9 9 0 CpXC protein zinc_ribbon_15 PF17032.3 NM_152412.2_3 - 0.33 11.6 53.4 1.6 9.4 2.5 6.7 1 1 4 6 6 6 0 zinc-ribbon family XPA_N PF01286.16 NM_152412.2_3 - 6.7 6.7 66.9 13 5.8 0.1 12.4 12 0 0 12 12 12 0 XPA protein N-terminal Mpp10 PF04006.10 NM_001318968.1_1 - 0.062 11.6 2.6 0.089 11.1 2.6 1.1 1 0 0 1 1 1 0 Mpp10 protein IF-2B PF01008.15 NM_001318968.1_3 - 1.1e-90 303.6 0.0 1.3e-90 303.3 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Pkinase PF00069.23 NM_005465.4_2 - 2.7e-76 256.3 0.0 3.8e-76 255.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_005465.4_2 - 3.3e-35 121.5 0.0 4.5e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.27 NM_005465.4_2 - 5.8e-14 52.3 0.1 1.1e-13 51.4 0.1 1.5 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.22 NM_005465.4_2 - 1.5e-08 35.1 2.6 2.7e-08 34.2 2.6 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_005465.4_2 - 1.9e-07 30.5 0.0 3.2e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Homeobox PF00046.27 NM_001204397.1_3 - 4.4e-22 77.5 9.2 7.9e-22 76.7 9.2 1.4 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 NM_001204397.1_3 - 8.2e-08 31.7 1.1 8.2e-08 31.7 1.1 1.8 2 0 0 2 2 2 1 OAR domain Homeobox_KN PF05920.9 NM_001204397.1_3 - 0.0071 16.1 0.6 0.021 14.6 0.6 1.8 1 0 0 1 1 1 1 Homeobox KN domain XRCC4 PF06632.10 NM_001204397.1_3 - 0.02 13.6 4.5 0.031 13.0 4.5 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Auxin_canalis PF05703.9 NM_001204397.1_3 - 6.3 6.5 5.6 11 5.8 5.6 1.2 1 0 0 1 1 1 0 Auxin canalisation zf-H2C2_2 PF13465.4 NM_152652.2_2 - 6.1e-68 222.3 69.2 4.5e-09 36.2 0.1 15.4 15 1 0 15 15 15 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_152652.2_2 - 7.7e-64 208.6 72.2 1.7e-06 28.0 0.5 12.4 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_152652.2_2 - 5.7e-39 129.3 71.4 0.008 16.8 1.3 12.4 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_152652.2_2 - 1.2e-26 92.2 21.5 0.25 11.5 0.0 12.2 12 0 0 12 12 12 8 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_152652.2_2 - 4e-15 55.2 67.4 0.0031 17.3 0.1 13.5 12 2 0 12 12 12 7 C2H2-type zinc finger DZR PF12773.5 NM_152652.2_2 - 3.1e-08 33.4 32.1 0.067 13.1 0.3 6.7 5 1 0 5 5 5 4 Double zinc ribbon XPA_N PF01286.16 NM_152652.2_2 - 9e-07 28.7 44.3 1.3 9.0 0.2 11.9 12 0 0 12 12 12 3 XPA protein N-terminal zf-C2H2_8 PF15909.3 NM_152652.2_2 - 4.4e-06 26.8 12.5 1.5 9.1 0.0 5.8 5 1 1 6 6 6 2 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.3 NM_152652.2_2 - 4.6e-06 27.1 20.3 1.3 9.7 0.1 6.1 5 1 1 6 6 6 2 zinc-ribbon family zf-Di19 PF05605.10 NM_152652.2_2 - 5.8e-06 26.4 34.6 0.11 12.6 1.3 6.7 6 0 0 6 6 6 2 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.8 NM_152652.2_2 - 8.5e-05 22.5 48.3 0.13 12.2 2.0 8.1 5 5 4 9 9 9 5 Zinc ribbon domain DUF3268 PF11672.6 NM_152652.2_2 - 0.00038 20.6 20.1 1 9.6 0.1 6.0 6 1 0 6 6 6 3 zinc-finger-containing domain zinc_ribbon_9 PF14369.4 NM_152652.2_2 - 0.00068 19.7 40.1 1.1 9.4 0.0 10.0 11 0 0 11 11 11 3 zinc-ribbon TerY_C PF15616.4 NM_152652.2_2 - 0.069 13.1 4.4 0.66 10.0 0.1 3.2 2 1 0 2 2 2 0 TerY-C metal binding domain C1_1 PF00130.20 NM_152652.2_2 - 0.086 12.6 26.6 5.1 6.9 0.1 8.0 5 5 4 9 9 9 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4428 PF14471.4 NM_152652.2_2 - 7.4 6.5 17.2 1.6 8.6 0.1 5.3 7 0 0 7 7 7 0 Domain of unknown function (DUF4428) GPR_Gpa2_C PF11970.6 NM_001294314.1_1 - 0.033 14.1 1.6 0.035 14.0 0.1 1.8 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term Fumarate_red_C PF02300.15 NM_001294314.1_1 - 0.16 12.0 4.0 1.3 8.9 1.8 2.2 2 0 0 2 2 2 0 Fumarate reductase subunit C 7tm_4 PF13853.4 NM_012367.1_1 - 4.3e-51 174.1 14.8 5.8e-51 173.7 14.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_012367.1_1 - 1.6e-26 93.0 17.8 3e-26 92.1 17.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_012367.1_1 - 0.0031 16.8 16.4 0.0097 15.2 16.4 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx zf-H2C2_2 PF13465.4 NM_001178090.2_1 - 2.4e-86 280.5 101.4 4.9e-09 36.1 0.3 14.2 13 1 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001178090.2_1 - 8.9e-64 208.4 97.9 1e-05 25.6 0.9 13.3 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001178090.2_1 - 3e-34 114.6 89.6 0.0022 18.6 0.9 12.8 12 0 0 12 12 12 12 C2H2-type zinc finger KRAB PF01352.25 NM_001178090.2_1 - 6.4e-26 89.6 0.1 1.2e-25 88.7 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001178090.2_1 - 5.8e-16 57.9 77.7 0.01 15.6 1.1 13.6 13 0 0 13 13 13 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001178090.2_1 - 2e-13 50.1 57.9 0.021 15.0 0.3 12.0 12 0 0 12 12 12 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001178090.2_1 - 5.6e-09 35.8 56.5 0.029 14.4 5.3 9.1 2 1 8 11 11 11 9 Zinc ribbon domain XPA_N PF01286.16 NM_001178090.2_1 - 0.00029 20.7 55.8 0.71 9.8 0.1 12.4 13 0 0 13 13 13 4 XPA protein N-terminal YhfH PF14149.4 NM_001178090.2_1 - 0.00047 19.9 27.7 13 5.8 0.1 9.2 9 0 0 9 9 9 0 YhfH-like protein BolA PF01722.16 NM_001178090.2_1 - 0.00095 19.3 26.2 0.39 10.9 0.2 6.8 2 2 3 7 7 7 5 BolA-like protein zinc_ribbon_15 PF17032.3 NM_001178090.2_1 - 0.0019 18.8 55.4 0.088 13.4 1.7 6.9 2 1 5 7 7 7 3 zinc-ribbon family zf-met PF12874.5 NM_001178090.2_1 - 0.0063 16.7 0.2 0.0063 16.7 0.2 10.9 13 0 0 13 13 11 3 Zinc-finger of C2H2 type BHD_1 PF10403.7 NM_001178090.2_1 - 0.17 11.6 1.5 15 5.4 0.0 4.2 5 1 0 5 5 5 0 Rad4 beta-hairpin domain 1 PTSIIA_gutA PF03829.11 NM_001178090.2_1 - 0.25 11.1 3.9 11 5.8 0.2 4.0 3 1 1 4 4 4 0 PTS system glucitol/sorbitol-specific IIA component Zf_RING PF16744.3 NM_001178090.2_1 - 0.36 10.8 44.6 4.2 7.4 0.7 10.9 1 1 11 12 12 12 0 KIAA1045 RING finger zf-C2H2_11 PF16622.3 NM_001178090.2_1 - 1.7 8.4 58.7 0.13 11.9 0.4 10.8 12 0 0 12 12 11 0 zinc-finger C2H2-type HypA PF01155.17 NM_001178090.2_1 - 3.4 7.6 45.4 1.7 8.5 5.3 6.9 1 1 4 5 5 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ta0938 PF11494.6 NM_001178090.2_1 - 7.5 6.8 22.2 1.3 9.2 0.1 5.9 1 1 4 6 6 6 0 Ta0938 3Beta_HSD PF01073.17 NM_001166120.1_1 - 1.3e-116 388.3 0.0 1.7e-116 388.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 NM_001166120.1_1 - 6.8e-22 78.0 0.0 1e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 NM_001166120.1_1 - 1.1e-15 57.4 0.0 2.3e-15 56.3 0.0 1.4 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 NM_001166120.1_1 - 1e-11 44.7 0.0 2e-11 43.7 0.0 1.4 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 NM_001166120.1_1 - 1.3e-10 40.8 0.0 2.1e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 NM_001166120.1_1 - 1.9e-09 37.6 0.0 3.2e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 NM_001166120.1_1 - 6.3e-08 31.9 0.0 9.2e-08 31.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.11 NM_001166120.1_1 - 3.9e-06 26.5 0.0 5.9e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.8 NM_001166120.1_1 - 4.4e-05 23.3 0.0 0.00011 22.1 0.0 1.6 1 0 0 1 1 1 1 KR domain Ldh_1_N PF00056.21 NM_001166120.1_1 - 0.022 14.7 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain PAX PF00292.16 NM_001127366.2_1 - 7.5e-76 251.9 0.8 1.1e-75 251.4 0.8 1.2 1 0 0 1 1 1 1 'Paired box' domain Pax7 PF12360.6 NM_001127366.2_1 - 1.3e-25 89.1 7.3 2.5e-25 88.2 7.3 1.5 1 0 0 1 1 1 1 Paired box protein 7 Homeobox PF00046.27 NM_001127366.2_1 - 2.2e-22 78.5 6.7 4.1e-22 77.6 6.7 1.5 1 0 0 1 1 1 1 Homeobox domain HTH_32 PF13565.4 NM_001127366.2_1 - 0.00029 21.3 7.0 0.0021 18.5 0.0 3.4 3 1 1 4 4 4 1 Homeodomain-like domain Homeobox_KN PF05920.9 NM_001127366.2_1 - 0.00066 19.4 0.6 0.0016 18.2 0.6 1.6 1 0 0 1 1 1 1 Homeobox KN domain HTH_23 PF13384.4 NM_001127366.2_1 - 0.0012 18.4 2.0 0.0067 16.1 0.1 2.5 2 0 0 2 2 2 1 Homeodomain-like domain F-box-like PF12937.5 NM_001184906.1_3 - 6.2e-12 45.1 1.7 1.2e-11 44.2 0.6 2.1 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.5 NM_001184906.1_3 - 8.4e-11 41.8 7.1 0.16 12.3 0.0 5.9 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 NM_001184906.1_3 - 3.6e-09 35.8 11.1 0.031 14.2 0.1 7.1 8 0 0 8 8 8 3 Leucine Rich repeat F-box PF00646.31 NM_001184906.1_3 - 8.6e-07 28.5 0.7 2.3e-06 27.2 0.7 1.8 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.3 NM_001184906.1_3 - 0.046 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 F-box MTS PF05175.12 NM_014168.3_2 - 1e-14 54.3 0.0 1.5e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.11 NM_014168.3_2 - 1.3e-11 44.3 0.1 1.9e-11 43.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.4 NM_014168.3_2 - 6.3e-11 42.2 0.2 9.6e-11 41.6 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_014168.3_2 - 1.4e-09 38.4 0.1 2.9e-09 37.4 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.13 NM_014168.3_2 - 2.1e-08 33.9 0.0 3.1e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.16 NM_014168.3_2 - 2.1e-07 30.7 0.1 1.1e-06 28.4 0.1 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.8 NM_014168.3_2 - 2.8e-07 30.3 0.0 4.1e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_12 PF08242.10 NM_014168.3_2 - 0.00038 21.0 0.0 0.00073 20.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DNA_methylase PF00145.15 NM_014168.3_2 - 0.0019 17.5 0.0 0.0034 16.6 0.0 1.3 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase DUF43 PF01861.14 NM_014168.3_2 - 0.0042 16.2 0.0 0.0057 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF43 Methyltransf_4 PF02390.15 NM_014168.3_2 - 0.0057 16.0 0.0 0.009 15.4 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase N6-adenineMlase PF10237.7 NM_014168.3_2 - 0.022 14.4 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase Methyltransf_9 PF08003.9 NM_014168.3_2 - 0.072 11.9 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Met_10 PF02475.14 NM_014168.3_2 - 0.075 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein FmrO PF07091.9 NM_014168.3_2 - 0.14 11.6 0.2 0.14 11.6 0.2 1.4 2 0 0 2 2 2 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_16 PF10294.7 NM_014168.3_2 - 0.16 11.5 0.4 0.39 10.3 0.1 1.6 2 0 0 2 2 2 0 Lysine methyltransferase TMEM171 PF15471.4 NM_173490.7_1 - 4.7e-175 581.0 0.5 5.7e-175 580.7 0.5 1.1 1 0 0 1 1 1 1 Transmembrane protein family 171 DUF2157 PF09925.7 NM_173490.7_1 - 0.0031 17.2 0.5 0.086 12.5 0.6 2.3 2 1 0 2 2 2 1 Predicted membrane protein (DUF2157) Tetraspannin PF00335.18 NM_173490.7_1 - 0.0054 16.4 8.9 0.049 13.3 0.6 2.1 2 0 0 2 2 2 2 Tetraspanin family Virul_fac_BrkB PF03631.13 NM_173490.7_1 - 0.01 15.3 1.3 0.02 14.4 0.0 1.9 1 1 1 2 2 2 0 Virulence factor BrkB DUF3040 PF11239.6 NM_173490.7_1 - 0.012 15.7 3.7 0.52 10.5 1.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF3040) DUF2371 PF10177.7 NM_173490.7_1 - 0.45 10.6 7.8 0.64 10.0 0.9 2.9 2 2 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) DUF981 PF06168.9 NM_173490.7_1 - 0.74 9.6 2.8 5.2 6.8 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF981) TctB PF07331.9 NM_173490.7_1 - 0.77 9.9 5.1 17 5.6 0.2 2.7 1 1 2 3 3 3 0 Tripartite tricarboxylate transporter TctB family WBP-1 PF11669.6 NM_173490.7_1 - 7 7.2 6.2 61 4.2 2.0 3.5 1 1 1 2 2 2 0 WW domain-binding protein 1 CLASP_N PF12348.6 NM_001321539.1_1 - 9.7e-16 57.9 1.8 5e-15 55.6 0.4 2.1 2 0 0 2 2 2 1 CLASP N terminal RTP1_C1 PF10363.7 NM_001321539.1_1 - 2.1e-06 27.7 1.5 0.19 11.8 0.1 3.4 2 1 0 2 2 2 2 Required for nuclear transport of RNA pol II C-terminus 1 UME PF08064.11 NM_001321539.1_1 - 6.8e-05 22.6 1.1 0.0034 17.2 0.1 2.8 2 0 0 2 2 2 1 UME (NUC010) domain RIX1 PF08167.10 NM_001321539.1_1 - 0.00029 20.5 0.2 0.14 11.8 0.0 3.1 2 1 1 3 3 3 2 rRNA processing/ribosome biogenesis Vac14_Fab1_bd PF12755.5 NM_001321539.1_1 - 0.00093 19.6 0.0 5.5 7.5 0.0 3.5 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.4 NM_001321539.1_1 - 0.005 17.1 2.7 0.71 10.2 0.1 3.9 3 2 2 5 5 5 1 HEAT repeats Dopey_N PF04118.12 NM_001321539.1_1 - 0.0093 15.0 3.7 0.22 10.5 0.1 2.6 2 1 1 3 3 3 1 Dopey, N-terminal HEAT PF02985.20 NM_001321539.1_1 - 0.055 13.6 2.1 4.6 7.6 0.0 4.4 5 0 0 5 5 5 0 HEAT repeat SPO22 PF08631.8 NM_001321539.1_1 - 0.12 11.7 0.1 0.82 9.0 0.0 2.1 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like DNA_alkylation PF08713.9 NM_001321539.1_1 - 0.15 11.6 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 DNA alkylation repair enzyme I-set PF07679.14 NM_001300911.1_1 - 7e-39 131.7 0.0 3.9e-19 68.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001300911.1_1 - 7.7e-28 96.8 0.0 6.5e-14 52.2 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001300911.1_1 - 9.5e-16 57.6 0.0 5.3e-07 29.6 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_001300911.1_1 - 4.8e-15 55.5 0.0 1.5e-06 28.3 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_001300911.1_1 - 2.1e-08 34.2 0.7 0.001 19.1 0.4 3.6 2 1 0 2 2 2 2 Immunoglobulin V-set domain BiPBP_C PF06832.10 NM_001300911.1_1 - 0.0023 17.8 0.0 0.14 12.1 0.0 3.1 2 1 1 3 3 3 1 Penicillin-Binding Protein C-terminus Family C2-set_2 PF08205.10 NM_001300911.1_1 - 0.0061 16.5 0.0 0.15 12.1 0.0 2.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_001300911.1_1 - 0.076 13.4 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Y_phosphatase PF00102.25 NM_007039.3_2 - 1.9e-71 240.2 0.1 2.7e-71 239.8 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_M PF00373.16 NM_007039.3_2 - 1.6e-21 76.8 1.4 3.6e-21 75.6 1.4 1.6 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.8 NM_007039.3_2 - 5.7e-17 61.8 0.3 1.2e-16 60.7 0.3 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_007039.3_2 - 5.2e-16 58.2 0.5 1.5e-15 56.8 0.2 1.9 2 0 0 2 2 2 1 FERM N-terminal domain DSPc PF00782.18 NM_007039.3_2 - 0.0025 17.5 0.0 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_007039.3_2 - 0.0039 17.1 0.0 0.0064 16.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Malic_M PF03949.13 NM_002395.5_2 - 8.8e-104 346.2 0.5 1.2e-103 345.8 0.5 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.17 NM_002395.5_2 - 1.6e-79 265.8 0.0 2.4e-79 265.2 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain GOLGA2L5 PF15070.4 NM_001282472.1_1 - 1.1e-09 37.5 0.0 1.5e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 GOLGA2L5 PF15070.4 NM_001282472.1_3 - 1.5e-45 155.9 63.7 3.5e-27 95.2 26.2 4.1 3 1 1 4 4 4 3 Putative golgin subfamily A member 2-like protein 5 APG6 PF04111.10 NM_001282472.1_3 - 8 5.6 58.4 0.05 12.8 11.4 3.2 3 0 0 3 3 3 0 Autophagy protein Apg6 PLA2G12 PF06951.9 NM_030821.4_2 - 4.8e-85 283.9 8.9 7.1e-85 283.4 8.9 1.2 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) Bromodomain PF00439.23 NM_001202464.1_3 - 2.9e-10 39.9 0.1 7.1e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.15 NM_001202464.1_3 - 8.3e-10 38.9 0.4 8.3e-10 38.9 0.4 3.0 2 1 0 2 2 2 1 PWWP domain DUF1002 PF06207.9 NM_001202464.1_3 - 0.18 11.2 1.6 0.37 10.2 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) Spore_III_AB PF09548.8 NM_001202464.1_3 - 3.8 7.5 7.1 1.6 8.7 4.4 1.8 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Peptidase_S64 PF08192.9 NM_001202464.1_3 - 4.1 5.6 17.1 6.3 5.0 17.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 zf-MYND PF01753.16 NM_001202464.1_3 - 4.6 7.3 32.3 0.035 14.1 22.1 2.8 3 0 0 3 3 3 0 MYND finger CHGN PF05679.14 NM_175856.4_1 - 1.3e-198 660.9 0.2 1.6e-198 660.6 0.2 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.14 NM_175856.4_1 - 7.4e-17 61.5 0.0 1.2e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Fringe-like Glyco_transf_7C PF02709.12 NM_175856.4_1 - 6.9e-09 35.1 0.1 2e-08 33.6 0.1 1.8 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Galactosyl_T PF01762.19 NM_175856.4_1 - 0.0034 17.1 0.0 0.064 12.9 0.1 2.6 3 0 0 3 3 3 1 Galactosyltransferase Glyco_tranf_2_2 PF10111.7 NM_175856.4_1 - 0.012 15.0 0.4 0.099 12.0 0.2 2.5 1 1 1 2 2 2 0 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.4 NM_175856.4_1 - 0.014 14.7 0.1 0.22 10.8 0.0 2.5 3 0 0 3 3 3 0 Glycosyl transferase family 21 Glycos_transf_2 PF00535.24 NM_175856.4_1 - 0.046 13.4 0.0 17 5.1 0.0 2.9 3 1 0 3 3 3 0 Glycosyl transferase family 2 Clat_adaptor_s PF01217.18 NM_001128126.2_3 - 4.9e-42 143.1 7.6 7.5e-42 142.5 7.6 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Fanconi_C PF02106.13 NM_001243743.1_1 - 1.1e-263 875.9 7.7 1.4e-263 875.6 7.7 1.1 1 0 0 1 1 1 1 Fanconi anaemia group C protein Nckap1 PF09735.7 NM_005337.4_2 - 0 1593.3 14.3 0 1593.1 14.3 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein Sushi PF00084.18 NM_001037175.2_2 - 2.6e-27 95.0 3.0 1.7e-10 41.2 0.1 3.4 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) HRM PF02793.20 NM_001037175.2_2 - 0.0002 21.5 2.4 0.58 10.4 0.0 3.2 3 0 0 3 3 3 2 Hormone receptor domain MoeA_C PF03454.13 NM_001037175.2_2 - 0.13 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 MoeA C-terminal region (domain IV) cEGF PF12662.5 NM_001037175.2_2 - 0.21 11.4 5.6 23 4.9 0.0 4.0 3 0 0 3 3 3 0 Complement Clr-like EGF-like tRNA_anti_2 PF13742.4 NM_004449.4_1 - 0.13 12.4 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Ets PF00178.20 NM_004449.4_3 - 1.3e-35 121.6 0.4 2.8e-35 120.5 0.4 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 NM_004449.4_3 - 9.1e-26 89.5 0.0 2.4e-25 88.2 0.0 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Pex14_N PF04695.11 NM_004449.4_3 - 0.95 10.0 3.4 1.2 9.7 0.4 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region 7tm_1 PF00001.19 NM_000707.3_3 - 1.5e-48 165.2 7.0 1.9e-48 164.9 7.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1856 PF08983.8 NM_000707.3_3 - 8.7e-09 35.4 6.3 3.2e-08 33.6 6.3 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1856) 7TM_GPCR_Srsx PF10320.7 NM_000707.3_3 - 2.3e-07 30.4 2.1 3.7e-07 29.6 2.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_000707.3_3 - 5.2e-05 23.0 1.5 9.1e-05 22.2 1.5 1.4 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.7 NM_000707.3_3 - 9.8e-05 21.7 0.0 0.00022 20.6 0.0 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Srg PF02118.19 NM_000707.3_3 - 0.014 14.9 3.6 0.031 13.8 3.6 1.5 1 0 0 1 1 1 0 Srg family chemoreceptor DUF5134 PF17197.2 NM_000707.3_3 - 0.47 10.2 3.6 0.35 10.7 1.2 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF5134) Calcyon PF06387.9 NM_014392.4_1 - 2.9e-83 278.2 0.1 3.9e-83 277.8 0.1 1.1 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) Sulfotransfer_1 PF00685.25 NM_006042.2_1 - 1.9e-42 145.4 0.0 2.8e-42 144.9 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_006042.2_1 - 8.4e-15 55.6 0.0 1.1e-09 38.9 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family zf-C2H2 PF00096.24 NM_016202.2_2 - 1.5e-13 50.3 12.1 1e-05 25.6 1.9 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_016202.2_2 - 4.2e-11 42.6 13.7 0.0072 16.9 1.8 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_016202.2_2 - 1.3e-09 37.9 0.1 0.11 12.7 0.0 3.4 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.4 NM_016202.2_2 - 1.9e-06 27.9 23.7 0.0012 19.1 0.4 4.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-met PF12874.5 NM_016202.2_2 - 3.5e-05 23.9 6.9 0.66 10.3 0.6 3.5 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-Di19 PF05605.10 NM_016202.2_2 - 0.001 19.2 4.9 0.0012 19.0 1.6 2.2 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.8 NM_016202.2_2 - 0.058 13.4 2.4 0.62 10.1 0.4 2.5 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2_9 PF16293.3 NM_016202.2_2 - 0.23 11.2 2.2 1.8 8.3 0.0 2.9 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) DZR PF12773.5 NM_016202.2_2 - 1.9 8.4 7.2 12 5.8 7.5 2.1 1 1 1 2 2 2 0 Double zinc ribbon eIF-5_eIF-2B PF01873.15 NM_001316363.1_1 - 6.3e-41 138.8 0.2 1.1e-40 138.0 0.2 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 HLH PF00010.24 NM_001322152.1_1 - 2.8e-10 39.8 1.5 1e-09 38.1 1.3 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Glyco_transf_25 PF01755.15 NM_001286760.1_1 - 2.7e-29 102.3 0.0 3.5e-28 98.7 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_tranf_2_4 PF13704.4 NM_001286760.1_1 - 4e-08 33.5 0.2 1.1e-07 32.1 0.2 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 2 Zona_pellucida PF00100.21 NM_001195683.1_3 - 2.9e-42 145.0 0.2 4.6e-42 144.4 0.2 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain Delta_lysin PF05372.9 NM_001195683.1_3 - 0.12 11.5 0.0 0.25 10.5 0.0 1.5 1 0 0 1 1 1 0 Delta lysin family tRNA_U5-meth_tr PF05958.9 NM_024917.5_3 - 6.5e-09 35.1 0.0 2.2e-08 33.4 0.0 1.7 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.4 NM_024917.5_3 - 5.8e-08 32.5 0.0 1.2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_024917.5_3 - 4.2e-07 30.5 0.0 7.5e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 NM_024917.5_3 - 9.1e-05 21.9 0.0 0.00015 21.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.15 NM_024917.5_3 - 0.0017 17.7 0.0 0.0027 17.1 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.11 NM_024917.5_3 - 0.021 14.1 0.0 0.03 13.6 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.10 NM_024917.5_3 - 0.025 15.2 0.0 0.042 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.4 NM_024917.5_3 - 0.025 14.4 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.10 NM_024917.5_3 - 0.059 13.9 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.16 NM_024917.5_3 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MARVEL PF01284.21 NM_001290189.1_1 - 2e-34 118.6 32.2 9.6e-20 70.9 5.7 2.9 2 0 0 2 2 2 2 Membrane-associating domain Calcipressin PF04847.10 NM_001285392.2_1 - 6e-62 208.6 1.0 8.4e-62 208.1 1.0 1.1 1 0 0 1 1 1 1 Calcipressin Ras PF00071.20 NM_206827.1_1 - 3.9e-29 101.2 0.0 5e-29 100.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_206827.1_1 - 8.4e-08 32.3 0.0 1.4e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.21 NM_206827.1_1 - 0.00031 20.7 0.0 0.00044 20.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.14 NM_206827.1_1 - 0.15 11.2 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 AIG1 family DUF3697 PF12478.6 NM_001287815.1_3 - 2.6e-15 56.1 0.2 5.8e-15 55.0 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin-associated protein 2 UBA_4 PF14555.4 NM_001287815.1_3 - 0.00032 20.3 0.0 0.00057 19.5 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain Comm PF15957.3 NM_001287815.1_3 - 0.02 15.1 0.2 0.11 12.7 0.2 2.3 1 0 0 1 1 1 0 Commissureless DUF1296 PF06972.9 NM_001287815.1_3 - 0.023 14.7 0.1 0.046 13.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) CUE PF02845.14 NM_001287815.1_3 - 0.22 11.1 2.1 0.31 10.6 0.2 2.1 2 0 0 2 2 2 0 CUE domain Pkinase PF00069.23 NM_001128919.2_1 - 6.6e-75 251.7 0.0 9.3e-75 251.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001128919.2_1 - 6.4e-44 150.1 0.0 9.4e-44 149.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 NM_001128919.2_1 - 6e-21 73.8 0.2 2e-20 72.1 0.0 1.9 2 0 0 2 2 2 1 Kinase associated domain 1 Kinase-like PF14531.4 NM_001128919.2_1 - 1.1e-06 28.0 0.0 1.8e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like UBA PF00627.29 NM_001128919.2_1 - 1.7e-05 24.4 0.0 3.1e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain RIO1 PF01163.20 NM_001128919.2_1 - 0.00042 19.8 0.2 0.00083 18.9 0.2 1.4 1 0 0 1 1 1 1 RIO1 family UBA_2 PF08587.9 NM_001128919.2_1 - 0.011 15.7 0.3 0.023 14.7 0.3 1.5 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) Kdo PF06293.12 NM_001128919.2_1 - 0.015 14.5 0.1 0.027 13.7 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PAF PF15715.3 NM_001128919.2_3 - 0.31 11.5 5.4 0.94 10.0 2.2 2.4 2 0 0 2 2 2 0 PCNA-associated factor 7tm_1 PF00001.19 NM_001286410.1_3 - 6.4e-66 222.2 16.0 8.5e-66 221.8 16.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) WAP PF00095.19 NM_130896.2_2 - 7.2e-22 77.4 69.0 6e-09 36.0 15.4 3.8 4 0 0 4 4 4 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' Kunitz_BPTI PF00014.21 NM_130896.2_2 - 1.3e-15 57.2 9.2 1.3e-15 57.2 9.2 3.0 4 0 0 4 4 4 1 Kunitz/Bovine pancreatic trypsin inhibitor domain zf-RING_2 PF13639.4 NM_001165034.1_2 - 7.8e-07 29.1 8.8 4.1e-06 26.8 8.8 2.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_001165034.1_2 - 2.9e-05 23.8 10.0 7.4e-05 22.5 10.0 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.23 NM_001165034.1_2 - 0.0022 17.7 10.1 0.0066 16.2 10.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_001165034.1_2 - 0.73 9.9 10.1 2.4 8.3 10.1 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FYVE PF01363.19 NM_001165034.1_2 - 2.7 8.0 9.7 6.2 6.9 9.7 1.5 1 0 0 1 1 1 0 FYVE zinc finger TraB PF01963.15 NM_001277053.1_3 - 3.7e-62 210.5 0.0 5.5e-62 209.9 0.0 1.3 1 0 0 1 1 1 1 TraB family Cadherin PF00028.15 NM_003737.3_3 - 0 1438.6 0.0 2.9e-26 91.6 0.0 27.7 27 1 0 27 27 27 27 Cadherin domain Cadherin_2 PF08266.10 NM_003737.3_3 - 2.7e-22 78.2 0.0 1.1 8.9 0.0 16.9 20 1 0 20 20 20 5 Cadherin-like Cadherin_3 PF16184.3 NM_003737.3_3 - 3.8e-18 65.4 0.0 0.1 12.5 0.0 13.7 17 0 0 17 17 17 4 Cadherin-like Cadherin_pro PF08758.9 NM_003737.3_3 - 3.2e-07 30.3 0.0 0.56 10.3 0.0 7.4 9 0 0 9 9 9 1 Cadherin prodomain like DUF3509 PF12021.6 NM_003737.3_3 - 0.014 15.0 0.2 26 4.5 0.0 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3509) Armet PF10208.7 NM_001029954.2_3 - 2e-68 228.7 6.2 2.7e-68 228.3 6.2 1.2 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding SAP PF02037.25 NM_001029954.2_3 - 0.11 12.1 0.1 0.43 10.3 0.0 2.1 2 0 0 2 2 2 0 SAP domain HeH PF12949.5 NM_001029954.2_3 - 0.13 11.8 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 HeH/LEM domain I-set PF07679.14 NM_030929.4_2 - 2.3e-12 46.7 0.0 3.3e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_030929.4_2 - 6.7e-12 45.7 0.0 1.1e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain IGFBP PF00219.16 NM_030929.4_2 - 8.2e-08 32.6 20.7 8.2e-08 32.6 20.7 2.7 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Ig_2 PF13895.4 NM_030929.4_2 - 2e-05 24.7 0.0 4.2e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Kazal_1 PF00050.19 NM_030929.4_2 - 2e-05 24.3 0.2 4.6e-05 23.2 0.2 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 NM_030929.4_2 - 2.3e-05 24.4 1.3 2.3e-05 24.4 1.3 1.9 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain ig PF00047.23 NM_030929.4_2 - 7.9e-05 22.6 0.0 0.0002 21.3 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 NM_030929.4_2 - 0.0013 18.7 0.0 0.0027 17.7 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain SCAMP PF04144.11 NM_001178112.1_1 - 5.8e-68 228.5 18.5 9.4e-68 227.8 18.5 1.3 1 0 0 1 1 1 1 SCAMP family WSC PF01822.17 NM_015253.1_1 - 5.5e-27 93.6 21.6 1.6e-17 63.3 6.6 3.1 4 0 0 4 4 4 2 WSC domain Sulfotransfer_1 PF00685.25 NM_015253.1_1 - 6e-06 25.8 0.1 1e-05 25.0 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_015253.1_1 - 0.054 13.7 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 Sulfotransferase family GLTT PF01744.18 NM_001206789.1_2 - 0.056 13.1 13.5 0.056 13.1 1.2 3.5 3 1 1 4 4 4 0 GLTT repeat (6 copies) Sporozoite_P67 PF05642.9 NM_001206789.1_2 - 4.5 5.1 8.1 6.6 4.5 8.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Trypsin PF00089.24 NM_001206789.1_3 - 1e-67 228.1 0.1 2.7e-67 226.7 0.1 1.7 2 0 0 2 2 2 1 Trypsin SRCR_2 PF15494.4 NM_001206789.1_3 - 2.7e-22 79.0 3.2 5.4e-22 78.0 3.2 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF1986 PF09342.9 NM_001206789.1_3 - 1.9e-06 28.1 0.0 4.3e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SRCR PF00530.16 NM_001206789.1_3 - 6.3e-05 23.3 1.5 0.00017 21.9 1.5 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Trypsin_2 PF13365.4 NM_001206789.1_3 - 0.001 19.9 0.0 0.0039 18.0 0.0 2.0 2 0 0 2 2 2 1 Trypsin-like peptidase domain Ldl_recept_a PF00057.16 NM_001206789.1_3 - 0.0029 17.6 3.0 0.0076 16.3 3.0 1.7 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A PDEase_I PF00233.17 NM_006661.3_3 - 1.7e-71 240.6 1.8 3.8e-71 239.5 0.4 2.0 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 NM_006661.3_3 - 2.9e-27 95.7 0.0 4.2e-18 66.0 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.4 NM_006661.3_3 - 1.7e-15 57.4 0.0 9.5e-08 32.3 0.0 2.2 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.4 NM_006661.3_3 - 3.7e-09 36.9 0.0 1.2e-05 25.5 0.0 2.3 2 0 0 2 2 2 2 GAF domain SpoVT_C PF15714.3 NM_006661.3_3 - 0.00042 20.2 0.0 0.012 15.5 0.0 2.3 2 0 0 2 2 2 1 Stage V sporulation protein T C-terminal, transcription factor HD PF01966.20 NM_006661.3_3 - 0.083 13.0 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 HD domain Crystallin PF00525.16 NM_000394.3_3 - 4.5e-26 90.7 2.3 8.4e-26 89.8 2.3 1.5 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.19 NM_000394.3_3 - 1.6e-21 76.2 0.0 2.1e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family PMG PF05287.10 NM_181622.1_1 - 1.3e-48 165.3 55.5 1.5e-48 165.1 55.5 1.0 1 0 0 1 1 1 1 PMG protein Keratin_B2 PF01500.15 NM_181622.1_1 - 0.25 11.2 43.1 1.4 8.8 10.1 2.2 1 1 1 2 2 2 0 Keratin, high sulfur B2 protein KRAB PF01352.25 NM_001291490.1_1 - 4.4e-18 64.5 0.8 8.8e-18 63.6 0.8 1.5 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 NM_001291490.1_3 - 7.8e-61 199.8 94.3 1.4e-08 34.7 0.3 13.8 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001291490.1_3 - 4.6e-43 143.2 98.8 1.2e-06 28.5 0.3 12.5 12 0 0 12 12 12 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001291490.1_3 - 3e-22 77.2 94.3 0.0014 19.2 0.2 12.3 12 0 0 12 12 12 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001291490.1_3 - 1.7e-09 37.6 36.7 0.2 11.9 0.3 9.9 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001291490.1_3 - 0.00012 22.0 67.3 0.014 15.4 4.1 9.3 7 2 4 11 11 11 7 Zinc ribbon domain XPA_N PF01286.16 NM_001291490.1_3 - 0.00021 21.1 44.9 1.1 9.2 0.3 10.3 10 0 0 10 10 10 5 XPA protein N-terminal zf-C2H2_6 PF13912.4 NM_001291490.1_3 - 0.002 17.9 77.8 0.029 14.2 0.1 11.7 12 0 0 12 12 12 6 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001291490.1_3 - 0.0067 16.0 0.8 0.0067 16.0 0.8 10.4 11 0 0 11 11 11 2 zinc-finger C2H2-type zf-trcl PF13451.4 NM_001291490.1_3 - 1.7 8.5 41.1 5.5 6.8 0.2 8.5 8 1 0 8 8 8 0 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 NM_001291490.1_3 - 8.6 7.1 41.1 2.5 8.8 1.2 6.2 2 1 4 6 6 6 0 zinc-ribbon family BCMA-Tall_bind PF09257.8 NM_001192.2_3 - 2.9e-22 78.3 10.3 8.9e-22 76.7 10.3 1.9 1 0 0 1 1 1 1 BCMA, TALL-1 binding TACI-CRD2 PF09305.8 NM_001192.2_3 - 0.0038 17.1 6.2 0.0097 15.8 6.2 1.7 1 0 0 1 1 1 1 TACI, cysteine-rich domain DUF4064 PF13273.4 NM_001192.2_3 - 0.063 13.5 0.0 0.097 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) DPPIV_N PF00930.19 NM_001321914.1_1 - 0.0022 16.7 0.0 0.0031 16.2 0.0 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DPPIV_N PF00930.19 NM_001321914.1_2 - 5.7e-100 334.4 0.6 7.8e-100 333.9 0.6 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 NM_001321914.1_2 - 1.6e-46 158.4 0.0 2.1e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.16 NM_001321914.1_2 - 5.4e-06 26.0 0.1 2.1e-05 24.1 0.1 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family PD40 PF07676.10 NM_001321914.1_2 - 0.019 14.8 0.3 4.6 7.2 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Abhydrolase_2 PF02230.14 NM_001321914.1_2 - 0.067 12.8 0.5 0.12 12.0 0.5 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.6 NM_001321914.1_2 - 0.18 10.9 0.2 7.2 5.7 0.1 2.1 1 1 1 2 2 2 0 Serine aminopeptidase, S33 7tm_1 PF00001.19 NM_002377.2_3 - 2.6e-15 56.2 30.0 8.4e-15 54.6 30.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 NM_002377.2_3 - 2.1e-05 23.9 15.6 2.1e-05 23.9 15.6 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.7 NM_002377.2_3 - 0.00066 19.1 11.2 0.00066 19.1 11.2 3.0 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srbc SAM_1 PF00536.28 NM_001037540.2_1 - 2.6e-18 66.1 0.0 4.5e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001037540.2_1 - 4.5e-06 26.5 0.0 1.3e-05 25.1 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_001037540.2_1 - 0.021 14.6 0.0 0.058 13.2 0.0 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain MMS19_N PF14500.4 NM_213631.2_1 - 0.022 14.2 4.1 0.46 9.9 1.1 2.8 2 1 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II NAC PF01849.16 NM_001113201.2_3 - 1e-24 86.2 0.9 2.3e-24 85.0 0.3 2.0 2 0 0 2 2 2 1 NAC domain RNA_pol_Rpo13 PF12136.6 NM_001113201.2_3 - 0.095 12.5 3.9 0.23 11.2 3.9 1.6 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain ECM1 PF05782.9 NM_001113201.2_3 - 2.3 6.9 9.7 0.071 11.9 2.4 1.8 2 0 0 2 2 2 0 Extracellular matrix protein 1 (ECM1) Mem_trans PF03547.16 NM_001113201.2_3 - 6.9 4.8 6.6 4.9 5.3 0.4 2.1 2 0 0 2 2 2 0 Membrane transport protein Gal-3-0_sulfotr PF06990.9 NM_001318116.1_1 - 1.6e-206 685.7 0.1 2e-206 685.5 0.1 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase BAF PF02961.12 NM_003860.3_2 - 1.5e-43 147.0 0.1 2.2e-43 146.5 0.1 1.2 1 0 0 1 1 1 1 Barrier to autointegration factor IMS_HHH PF11798.6 NM_003860.3_2 - 0.019 15.1 0.1 0.041 14.1 0.1 1.6 1 0 0 1 1 1 0 IMS family HHH motif SBF2 PF12335.6 NM_001286566.1_2 - 0.00071 19.1 0.1 0.0022 17.5 0.0 1.7 2 0 0 2 2 2 1 Myotubularin protein PRELI PF04707.12 NM_001142406.1_3 - 2.5e-49 167.0 0.0 3.3e-49 166.6 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family IRK PF01007.18 NM_021012.4_1 - 1.2e-156 520.6 0.1 1.6e-156 520.2 0.1 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel IRK_N PF08466.8 NM_021012.4_1 - 7.5e-24 83.5 0.6 1.5e-23 82.5 0.6 1.5 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.14 NM_021012.4_1 - 0.007 16.2 1.8 0.016 15.1 1.8 1.6 1 0 0 1 1 1 1 Ion channel Glyco_trans_1_4 PF13692.4 NM_001015050.2_2 - 0.0059 16.9 0.0 0.0086 16.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.18 NM_001015050.2_2 - 0.0088 15.5 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Sacchrp_dh_C PF16653.3 NM_005763.3_2 - 8e-83 278.4 0.0 1.2e-82 277.8 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain AlaDh_PNT_N PF05222.13 NM_005763.3_2 - 3.5e-25 88.7 0.0 6e-25 88.0 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Sacchrp_dh_NADP PF03435.16 NM_005763.3_2 - 2e-21 76.5 0.0 3.3e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.19 NM_005763.3_2 - 1.3e-05 24.5 0.0 0.00018 20.8 0.0 2.5 2 1 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain RVT_1 PF00078.25 NM_005763.3_2 - 1.5e-05 24.5 0.0 2.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Shikimate_DH PF01488.18 NM_005763.3_2 - 0.084 12.8 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ski_Sno PF02437.15 NM_001278063.1_1 - 8.5e-39 131.6 0.2 1.6e-38 130.6 0.2 1.4 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.8 NM_001278063.1_1 - 3.9e-32 110.2 1.7 3.9e-32 110.2 1.7 2.1 3 0 0 3 3 3 1 c-SKI Smad4 binding domain BROMI PF14961.4 NM_152730.5_2 - 0 2247.0 29.5 0 1492.6 15.1 2.0 1 1 1 2 2 2 2 Broad-minded protein Ins_allergen_rp PF06757.11 NM_152730.5_2 - 0.064 13.1 3.4 4 7.3 0.2 2.5 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification SM-ATX PF14438.4 NM_148415.2_3 - 1.4e-19 69.9 0.0 2.4e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain LsmAD PF06741.11 NM_148415.2_3 - 1.5e-17 63.8 1.9 2.4e-17 63.1 1.9 1.4 1 0 0 1 1 1 1 LsmAD domain PAM2 PF07145.13 NM_148415.2_3 - 1.4e-05 24.3 1.0 4.2e-05 22.8 1.0 1.9 1 0 0 1 1 1 1 Ataxin-2 C-terminal region LSM14 PF12701.5 NM_148415.2_3 - 0.041 13.8 0.0 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Scd6-like Sm domain Vps26 PF03643.13 NM_001318944.1_1 - 1.3e-116 388.4 3.3 1.7e-116 387.9 3.3 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Vps26 PF03643.13 NM_001318944.1_3 - 2.8e-09 36.3 0.0 4e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Pkinase_Tyr PF07714.15 NM_001202522.1_1 - 6.5e-79 264.7 0.0 8.8e-79 264.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001202522.1_1 - 3.1e-36 125.0 0.0 4.6e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 NM_001202522.1_1 - 3.3e-20 72.3 0.0 5.2e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Lamprin PF06403.9 NM_001202522.1_1 - 0.026 14.4 0.4 0.059 13.2 0.4 1.5 1 0 0 1 1 1 0 Lamprin Kinase-like PF14531.4 NM_001202522.1_1 - 0.062 12.5 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like TauD PF02668.14 NM_001184797.1_1 - 1.9e-24 86.7 0.0 2.9e-24 86.2 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.10 NM_001184797.1_1 - 1.1e-11 45.1 1.6 2.2e-11 44.1 1.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CSD PF00313.20 NM_001278261.1_2 - 3.1e-11 42.8 0.0 6e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.9 NM_001278261.1_2 - 0.077 12.6 0.1 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 Ribonuclease B OB domain DUF4339 PF14237.4 NM_001278261.1_3 - 0.065 12.9 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4339) WD40 PF00400.30 NM_018268.3_3 - 4e-15 55.8 3.4 0.00085 20.0 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat Alpha_kinase PF02816.16 NM_001177310.1_1 - 6.5e-42 143.7 0.0 2e-41 142.1 0.0 1.9 1 0 0 1 1 1 1 Alpha-kinase family TRPM_tetra PF16519.3 NM_001177310.1_1 - 2.9e-24 84.8 2.0 6.8e-24 83.6 2.0 1.7 1 0 0 1 1 1 1 Tetramerisation domain of TRPM BolA PF01722.16 NM_001320622.1_2 - 8.4e-05 22.6 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 BolA-like protein LLGL PF08366.11 NM_139244.4_2 - 3.7e-33 113.8 0.0 7.1e-33 112.9 0.0 1.5 1 0 0 1 1 1 1 LLGL2 ANAPC4_WD40 PF12894.5 NM_139244.4_2 - 7.3e-09 35.7 0.2 0.11 12.7 0.0 5.4 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 NM_139244.4_2 - 1.7e-06 28.5 7.2 0.056 14.2 0.3 5.5 4 1 0 4 4 4 2 WD domain, G-beta repeat Lgl_C PF08596.8 NM_139244.4_2 - 2.9e-06 26.1 0.0 3.3e-05 22.6 0.0 2.4 4 0 0 4 4 4 1 Lethal giant larvae(Lgl) like, C-terminal Synaptobrevin PF00957.19 NM_139244.4_2 - 0.0037 16.9 0.0 0.011 15.4 0.0 1.8 1 0 0 1 1 1 1 Synaptobrevin RAB3GAP2_N PF14655.4 NM_139244.4_2 - 0.058 12.5 0.0 4.2 6.3 0.0 2.8 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Il2rg PF15874.3 NM_182520.2_2 - 9.2e-29 99.3 0.0 1.2e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 Putative Interleukin 2 receptor, gamma chain Rubrerythrin PF02915.15 NM_182520.2_2 - 0.042 14.1 0.0 0.062 13.6 0.0 1.2 1 0 0 1 1 1 0 Rubrerythrin zf-H2C2_2 PF13465.4 NM_198855.3_1 - 4.3e-86 279.7 96.1 1.5e-09 37.8 0.3 16.3 17 0 0 17 17 17 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_198855.3_1 - 5e-60 196.6 102.3 3.9e-07 30.0 1.7 13.6 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_198855.3_1 - 3e-31 105.2 104.2 0.0016 19.0 0.5 13.9 13 0 0 13 13 13 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_198855.3_1 - 4.9e-22 77.2 88.1 1.7e-05 24.5 0.3 12.5 12 0 0 12 12 12 10 C2H2-type zinc finger KRAB PF01352.25 NM_198855.3_1 - 1.3e-21 75.9 1.4 2.5e-21 74.9 1.4 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_198855.3_1 - 7.8e-10 38.6 51.1 0.0019 18.2 1.6 8.4 7 1 1 8 8 8 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_198855.3_1 - 0.0057 16.8 48.2 0.21 11.8 0.1 11.0 11 0 0 11 11 11 3 Zinc-finger double-stranded RNA-binding FYDLN_acid PF09538.8 NM_198855.3_1 - 0.29 11.7 22.5 15 6.2 0.1 8.0 2 1 6 9 9 9 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_15 PF17032.3 NM_198855.3_1 - 0.96 10.1 54.1 0.55 10.9 1.3 6.7 2 1 5 7 7 7 0 zinc-ribbon family Zn_ribbon_recom PF13408.4 NM_198855.3_1 - 8.2 6.9 52.0 9.1 6.8 2.3 7.3 4 1 2 6 6 6 0 Recombinase zinc beta ribbon domain Serpin PF00079.18 NM_000934.3_3 - 2.3e-88 296.9 0.0 2.8e-88 296.6 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4460 PF14687.4 NM_001029840.2_3 - 5.1e-10 39.3 0.0 9.2e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) HSCB_C PF07743.11 NM_001318314.1_1 - 4.3e-07 30.2 0.2 6.4e-07 29.6 0.2 1.2 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.29 NM_001318314.1_2 - 0.0002 21.3 0.1 0.00029 20.8 0.1 1.2 1 0 0 1 1 1 1 DnaJ domain zf-RING_9 PF13901.4 NM_001242819.1_3 - 7.5e-55 186.0 28.3 5.5e-53 179.9 16.1 3.4 2 1 0 2 2 2 2 Putative zinc-RING and/or ribbon C1_1 PF00130.20 NM_001242819.1_3 - 9.8e-07 28.4 8.7 9.8e-07 28.4 8.7 5.0 5 1 0 5 5 5 2 Phorbol esters/diacylglycerol binding domain (C1 domain) DDHD PF02862.15 NM_001160147.1_3 - 1.6e-52 178.9 0.0 2.3e-52 178.4 0.0 1.3 1 0 0 1 1 1 1 DDHD domain WWE PF02825.18 NM_001160147.1_3 - 0.0073 16.7 0.4 0.43 11.0 0.0 2.6 2 0 0 2 2 2 1 WWE domain Peptidase_M20 PF01546.26 NM_001198898.1_1 - 1.4e-35 122.8 0.0 1.7e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 NM_001198898.1_1 - 7.2e-14 51.5 0.0 1.2e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.15 NM_001198898.1_1 - 8.2e-06 25.5 0.0 0.00025 20.6 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M28 PCMT PF01135.17 NM_001252053.1_1 - 6.5e-86 287.3 0.0 7.9e-86 287.0 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.4 NM_001252053.1_1 - 9.3e-07 29.4 0.0 1.6e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001252053.1_1 - 6.3e-05 22.7 0.0 0.00016 21.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001252053.1_1 - 0.00016 22.1 0.1 0.00043 20.7 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 NM_001252053.1_1 - 0.00039 20.2 0.0 0.0011 18.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 NM_001252053.1_1 - 0.00043 19.6 0.0 0.00066 18.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.11 NM_001252053.1_1 - 0.0023 17.2 0.1 0.003 16.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) GCD14 PF08704.8 NM_001252053.1_1 - 0.0025 17.4 0.0 0.0035 16.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit MTS PF05175.12 NM_001252053.1_1 - 0.082 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.17 NM_001252053.1_1 - 0.16 11.9 0.1 0.42 10.6 0.1 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase TRIQK PF15168.4 NM_001191036.1_2 - 1.5e-37 127.2 1.0 2.9e-37 126.3 1.0 1.5 1 0 0 1 1 1 1 Triple QxxK/R motif-containing protein family Trypsin PF00089.24 NM_000204.4_3 - 4.5e-62 209.6 0.5 7.7e-62 208.8 0.5 1.4 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.16 NM_000204.4_3 - 2.9e-16 59.3 22.4 5.3e-12 45.6 6.8 4.1 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A SRCR PF00530.16 NM_000204.4_3 - 3.5e-13 49.8 2.8 1.5e-12 47.7 0.9 2.8 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Trypsin_2 PF13365.4 NM_000204.4_3 - 2.1e-06 28.6 0.0 3.9e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain SRCR_2 PF15494.4 NM_000204.4_3 - 0.0066 16.8 0.3 0.0066 16.8 0.3 2.1 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain VERL PF11386.6 NM_000204.4_3 - 0.071 13.2 1.1 2.2 8.4 0.2 2.6 2 0 0 2 2 2 0 Vitelline envelope receptor for lysin BolA PF01722.16 NM_001320579.1_2 - 3.5e-16 59.1 0.0 5.3e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein F5_F8_type_C PF00754.23 NM_001310320.1_3 - 3.7e-62 208.0 3.7 3e-34 117.7 1.6 2.1 2 0 0 2 2 2 2 F5/8 type C domain EGF PF00008.25 NM_001310320.1_3 - 2.4e-07 30.8 6.3 2.4e-07 30.8 6.3 2.4 3 0 0 3 3 3 1 EGF-like domain cEGF PF12662.5 NM_001310320.1_3 - 0.073 12.9 5.0 0.21 11.4 5.0 1.8 1 0 0 1 1 1 0 Complement Clr-like EGF-like EGF_3 PF12947.5 NM_001310320.1_3 - 0.47 10.6 7.2 1.2 9.3 7.2 1.7 1 0 0 1 1 1 0 EGF domain Ras PF00071.20 NM_001286201.1_3 - 1.4e-27 96.1 0.0 1.8e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001286201.1_3 - 9.6e-07 28.9 0.0 1.5e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001286201.1_3 - 0.0043 16.4 0.0 0.006 15.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family CTNNB1_binding PF08347.9 NM_016269.4_2 - 2.6e-85 285.6 4.0 2.6e-85 285.6 4.0 1.9 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 NM_016269.4_2 - 9.4e-22 77.1 0.7 3.2e-21 75.4 0.7 2.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_016269.4_2 - 1e-07 32.3 0.8 1e-07 32.3 0.8 2.0 2 0 0 2 2 2 1 HMG-box domain EGF_CA PF07645.13 NM_024324.4_3 - 1.4e-11 44.2 33.4 1.8e-09 37.5 9.8 5.9 3 2 2 5 5 5 2 Calcium-binding EGF domain DUF3456 PF11938.6 NM_024324.4_3 - 3.6e-08 34.0 1.7 0.00078 19.9 0.0 2.5 1 1 1 2 2 2 2 TLR4 regulator and MIR-interacting MSAP VSP PF03302.11 NM_024324.4_3 - 0.061 12.0 55.5 0.17 10.6 24.0 3.2 1 1 2 3 3 3 0 Giardia variant-specific surface protein PARG_cat PF05028.12 NM_001303486.1_2 - 4e-134 447.0 0.0 5.8e-134 446.5 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) UNC-93 PF05978.14 NM_030930.3_2 - 9.6e-06 25.3 4.8 2.1e-05 24.1 3.1 3.4 4 0 0 4 4 4 2 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.22 NM_006931.2_2 - 1.1e-155 518.8 21.8 1.3e-155 518.5 21.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 NM_006931.2_2 - 1.3e-14 53.8 34.0 8.8e-14 51.1 21.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.10 NM_006931.2_2 - 0.48 10.7 5.1 1.3 9.4 5.1 1.7 1 0 0 1 1 1 0 Phage holin family 2 IL6Ra-bind PF09240.8 NM_006140.4_3 - 5.2e-23 81.2 0.5 5.5e-22 77.9 0.0 2.3 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding VEGF_C PF14554.4 NM_001171623.1_1 - 9.4e-28 96.0 17.5 2.8e-27 94.4 17.5 1.8 1 0 0 1 1 1 1 VEGF heparin-binding domain PDGF PF00341.15 NM_001171623.1_1 - 3.5e-26 91.2 5.3 3.5e-26 91.2 5.3 1.9 2 0 0 2 2 2 1 PDGF/VEGF domain WH1 PF00568.21 NM_003370.3_1 - 2.1e-38 130.5 0.0 3.1e-38 130.0 0.0 1.2 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 NM_003370.3_1 - 6.4e-16 57.5 8.6 1e-15 56.8 8.6 1.3 1 0 0 1 1 1 1 VASP tetramerisation domain ASD2 PF08687.9 NM_003370.3_1 - 0.01 15.3 2.6 0.015 14.8 2.6 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Ran_BP1 PF00638.16 NM_003370.3_1 - 0.03 14.5 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 RanBP1 domain PFK PF00365.18 NM_001323071.1_1 - 3.9e-199 659.4 6.3 8e-106 353.3 1.4 2.1 2 0 0 2 2 2 2 Phosphofructokinase Hrs_helical PF12210.6 NM_001323071.1_1 - 0.23 11.9 1.1 21 5.6 0.0 2.8 3 0 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Hormone_recep PF00104.28 NM_021005.3_1 - 4.7e-39 134.0 0.1 7e-39 133.4 0.1 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_021005.3_1 - 6.8e-31 106.4 16.3 1.6e-30 105.2 16.3 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Arm PF00514.21 NM_001085465.1_1 - 2.5e-32 109.8 5.6 9.3e-08 31.7 0.0 7.2 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 NM_001085465.1_1 - 1.7e-05 25.0 0.3 8 6.9 0.0 4.9 5 0 0 5 5 5 3 HEAT-like repeat HEAT_2 PF13646.4 NM_001085465.1_1 - 0.0017 18.6 0.3 1.8 8.9 0.1 2.6 2 0 0 2 2 2 2 HEAT repeats Cnd1 PF12717.5 NM_001085465.1_1 - 0.0091 15.9 1.1 0.041 13.7 0.2 2.3 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 NM_001085465.1_1 - 0.086 13.0 1.4 98 3.5 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat Atx10homo_assoc PF09759.7 NM_001085465.1_1 - 0.29 11.1 2.0 1.6 8.7 0.0 2.9 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain 7tm_4 PF13853.4 NM_013940.2_3 - 8.4e-51 173.2 15.5 1e-50 172.9 15.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_013940.2_3 - 1.6e-21 76.6 10.8 2.5e-21 76.0 10.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_013940.2_3 - 7.5e-06 25.4 13.7 1.5e-05 24.4 13.7 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx HEAT PF02985.20 NM_001288814.1_2 - 1.7e-11 43.2 23.8 0.00049 20.0 0.1 10.6 13 0 0 13 13 13 3 HEAT repeat HEAT_2 PF13646.4 NM_001288814.1_2 - 4.2e-11 42.9 17.3 0.04 14.2 0.1 8.9 8 1 0 8 8 8 2 HEAT repeats Cnd1 PF12717.5 NM_001288814.1_2 - 3e-08 33.7 1.9 10 6.0 0.0 7.3 8 0 0 8 8 8 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 NM_001288814.1_2 - 7.7e-08 32.5 34.3 0.0022 18.3 0.2 11.4 10 2 2 12 12 12 2 HEAT-like repeat Arm PF00514.21 NM_001288814.1_2 - 0.007 16.2 4.4 1.6 8.7 0.1 5.1 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.7 NM_001288814.1_2 - 0.0075 16.3 3.3 1.8 8.6 0.0 5.3 5 1 1 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.5 NM_001288814.1_2 - 0.017 15.2 1.8 0.18 11.9 0.4 3.0 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Prefoldin PF02996.15 NM_001303543.1_1 - 6.2e-38 129.3 0.9 9.5e-38 128.7 0.9 1.3 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.18 NM_001303543.1_1 - 0.0014 18.4 4.7 0.02 14.7 0.0 2.3 2 0 0 2 2 2 2 Prefoldin subunit Chromo PF00385.22 NM_020649.2_2 - 1.9e-14 53.2 0.3 1.9e-14 53.2 0.3 1.8 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain CBX7_C PF17218.1 NM_020649.2_2 - 2.5e-14 52.5 3.8 4.3e-14 51.8 3.8 1.4 1 0 0 1 1 1 1 CBX family C-terminal motif Atrophin-1 PF03154.13 NM_020649.2_2 - 0.00072 17.9 16.0 0.0013 17.0 16.0 1.3 1 0 0 1 1 1 1 Atrophin-1 family RBR PF17208.1 NM_020649.2_2 - 0.0034 18.0 4.1 0.94 10.1 0.0 2.7 2 0 0 2 2 2 2 RNA binding Region DUF1777 PF08648.10 NM_020649.2_2 - 0.0067 16.6 21.7 0.011 15.8 21.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) Mtf2_C PF14061.4 NM_020649.2_2 - 0.037 14.1 0.3 0.072 13.1 0.3 1.5 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 MIP-T3 PF10243.7 NM_020649.2_2 - 0.24 9.9 10.8 0.32 9.5 10.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Auts2 PF15336.4 NM_020649.2_2 - 0.66 9.9 14.2 1.4 8.9 14.2 1.5 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein PRP38_assoc PF12871.5 NM_020649.2_2 - 8 6.9 40.6 4.9 7.6 37.9 2.1 1 1 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Trypan_PARP PF05887.9 NM_020649.2_2 - 8.7 6.2 9.2 18 5.2 9.2 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RIC3 PF15361.4 NM_174923.2_1 - 1.2e-05 25.6 0.0 2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 RskA PF10099.7 NM_174923.2_1 - 0.0054 16.9 2.6 0.0054 16.9 2.6 2.2 1 1 1 2 2 2 1 Anti-sigma-K factor rskA DASH_Hsk3 PF08227.9 NM_174923.2_1 - 0.042 14.1 6.4 0.085 13.1 6.4 1.5 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like HrpB7 PF09486.8 NM_174923.2_1 - 0.057 13.7 1.1 0.087 13.1 1.1 1.2 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF948 PF06103.9 NM_174923.2_1 - 0.12 12.6 0.3 0.26 11.4 0.3 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) IncA PF04156.12 NM_174923.2_1 - 0.13 11.9 10.1 0.5 10.0 10.1 1.8 1 1 0 1 1 1 0 IncA protein IATP PF04568.10 NM_174923.2_1 - 3.4 8.0 7.0 2.5 8.4 1.6 2.3 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Nebulin PF00880.16 NM_001164507.1_3 - 0 3468.8 978.9 3.8e-09 36.2 2.5 224.9 230 0 0 230 230 230 196 Nebulin repeat Peptidase_M24 PF00557.22 NM_001164507.1_3 - 1.9e-20 73.3 10.4 0.31 10.5 0.0 12.9 12 0 0 12 12 12 6 Metallopeptidase family M24 SH3_9 PF14604.4 NM_001164507.1_3 - 2.5e-12 46.3 0.0 5.6e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001164507.1_3 - 5.1e-12 45.1 0.0 2.3e-11 43.0 0.0 2.3 1 0 0 1 1 1 1 SH3 domain NFRKB_winged PF14465.4 NM_001164507.1_3 - 2.5e-06 27.5 44.7 1.5 8.9 0.1 13.3 15 0 0 15 15 15 5 NFRKB Winged Helix-like SH3_2 PF07653.15 NM_001164507.1_3 - 1.7e-05 24.3 0.0 0.00085 18.8 0.0 4.0 4 0 0 4 4 4 1 Variant SH3 domain DUF1310 PF07006.9 NM_001164507.1_3 - 0.0033 17.3 4.1 50 3.8 0.0 6.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1310) DUF3410 PF11890.6 NM_001164507.1_3 - 1 9.0 22.5 5.1 6.8 0.2 8.2 8 0 0 8 8 8 0 Domain of unknown function (DUF3410) IlvC PF01450.17 NM_001164507.1_3 - 1.8 8.7 4.7 6.8 6.8 0.6 3.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain DUF4499 PF14934.4 NM_001270369.1_1 - 4.4e-21 74.9 1.1 9.7e-21 73.8 1.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) DUF4499 PF14934.4 NM_001270369.1_2 - 2.6e-05 24.3 1.1 5.9e-05 23.2 1.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) IL8 PF00048.18 NM_005409.4_1 - 3.6e-09 36.5 1.3 7.3e-09 35.5 1.3 1.6 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Peptidase_C14 PF00656.20 NM_032974.4_2 - 6.5e-40 137.5 0.0 1e-39 136.8 0.0 1.3 1 0 0 1 1 1 1 Caspase domain DED PF01335.19 NM_032974.4_2 - 6.2e-39 132.0 19.9 6.6e-20 71.1 4.2 2.9 3 0 0 3 3 3 2 Death effector domain Imm30 PF15565.4 NM_032974.4_2 - 0.023 14.7 0.1 0.072 13.1 0.1 1.8 1 1 0 1 1 1 0 Immunity protein 30 MMtag PF10159.7 NM_024319.3_2 - 1.9e-30 104.9 0.2 1.9e-30 104.9 0.2 2.3 2 0 0 2 2 1 1 Kinase phosphorylation protein Presenilin PF01080.15 NM_024319.3_2 - 0.061 11.9 3.8 0.079 11.6 3.8 1.1 1 0 0 1 1 1 0 Presenilin DUF3987 PF13148.4 NM_024319.3_2 - 0.064 12.1 2.7 0.091 11.6 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) SRP-alpha_N PF04086.11 NM_024319.3_2 - 0.1 12.4 13.2 0.13 12.0 13.2 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal MIP-T3 PF10243.7 NM_024319.3_2 - 0.32 9.5 18.6 0.39 9.3 18.6 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1510 PF07423.9 NM_024319.3_2 - 0.6 9.4 7.6 1 8.6 7.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RR_TM4-6 PF06459.10 NM_024319.3_2 - 0.63 9.7 11.2 0.89 9.2 11.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Coilin_N PF15862.3 NM_024319.3_2 - 0.74 9.5 14.1 1.3 8.6 14.1 1.4 1 0 0 1 1 1 0 Coilin N-terminus Med19 PF10278.7 NM_024319.3_2 - 1 9.1 17.9 1.8 8.3 17.9 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 U79_P34 PF03064.14 NM_024319.3_2 - 2.1 7.5 18.7 3.1 6.9 18.7 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 SAPS PF04499.13 NM_024319.3_2 - 2.6 6.6 5.2 3.5 6.2 5.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.14 NM_024319.3_2 - 2.7 7.9 5.0 3.9 7.3 5.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AP3D1 PF06375.9 NM_024319.3_2 - 6.7 6.8 20.1 12 6.0 20.1 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 zf-H2C2_2 PF13465.4 NM_001159524.1_1 - 1.3e-59 196.0 71.9 5.2e-09 36.0 1.3 9.8 10 0 0 10 10 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001159524.1_1 - 3.9e-30 102.5 63.6 2.4e-05 24.4 0.5 9.6 9 0 0 9 9 9 7 Zinc finger, C2H2 type KRAB PF01352.25 NM_001159524.1_1 - 1.1e-22 79.3 0.1 1.9e-22 78.5 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001159524.1_1 - 7.1e-16 57.4 60.2 0.0079 16.8 1.4 9.5 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001159524.1_1 - 2.8e-10 40.1 28.7 0.33 11.2 0.9 8.2 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001159524.1_1 - 6.4e-09 35.6 33.6 0.77 9.7 0.3 7.7 7 0 0 7 7 7 6 XPA protein N-terminal zf-C2H2_6 PF13912.4 NM_001159524.1_1 - 4.3e-08 32.8 42.8 0.083 12.7 0.2 8.7 8 0 0 8 8 8 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001159524.1_1 - 4.4e-06 26.6 50.9 0.00061 19.7 2.4 6.7 5 1 3 8 8 7 4 Zinc ribbon domain zf-RING_7 PF02591.13 NM_001159524.1_1 - 2.9e-05 24.0 24.2 1.5 8.9 0.1 7.6 7 0 0 7 7 7 2 C4-type zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001159524.1_1 - 7.8e-05 22.2 31.1 1.7 8.3 0.1 8.2 8 0 0 8 8 7 2 zinc-finger C2H2-type DUF3268 PF11672.6 NM_001159524.1_1 - 0.0011 19.1 25.0 0.16 12.2 2.3 4.5 2 1 2 5 5 5 4 zinc-finger-containing domain zf-trcl PF13451.4 NM_001159524.1_1 - 0.0012 18.6 33.3 2.2 8.1 3.4 8.0 7 1 1 8 8 8 1 Probable zinc-ribbon domain C1_4 PF07975.10 NM_001159524.1_1 - 0.0032 17.6 43.7 0.2 11.8 1.0 7.7 2 1 5 8 8 8 2 TFIIH C1-like domain CpXC PF14353.4 NM_001159524.1_1 - 0.0049 16.7 27.8 0.74 9.7 0.9 7.1 2 2 4 6 6 6 1 CpXC protein ADK_lid PF05191.12 NM_001159524.1_1 - 0.0055 16.6 22.4 2 8.4 3.8 5.4 2 1 3 5 5 5 2 Adenylate kinase, active site lid BHD_1 PF10403.7 NM_001159524.1_1 - 0.0059 16.3 1.5 0.16 11.7 0.1 3.7 5 0 0 5 5 5 1 Rad4 beta-hairpin domain 1 DUF1151 PF06625.9 NM_001159524.1_1 - 0.034 13.9 0.0 0.093 12.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) BolA PF01722.16 NM_001159524.1_1 - 0.21 11.7 11.8 17 5.6 0.1 4.7 3 1 2 5 5 5 0 BolA-like protein FerB PF08150.10 NM_001159524.1_1 - 1.4 9.4 4.6 8.1 7.0 0.2 3.3 2 1 1 3 3 3 0 FerB (NUC096) domain Metallothio_Pro PF02069.14 NM_001159524.1_1 - 1.4 9.0 33.5 1.5 9.0 0.7 7.4 2 2 5 7 7 7 0 Prokaryotic metallothionein Desulfoferrod_N PF06397.10 NM_001159524.1_1 - 1.9 8.0 26.1 8.2 6.0 0.0 7.3 7 0 0 7 7 7 0 Desulfoferrodoxin, N-terminal domain PDDEXK_10 PF07788.9 NM_001159524.1_2 - 0.061 13.1 0.0 2.3e+02 1.7 0.0 4.7 5 1 0 5 5 5 0 PD-(D/E)XK nuclease superfamily DUF1220 PF06758.11 NM_001037501.2_2 - 3.9e-167 542.7 80.0 9.6e-28 96.2 3.2 8.5 8 0 0 8 8 8 7 Repeat of unknown function (DUF1220) GAT PF03127.12 NM_001037501.2_2 - 0.00019 21.5 12.6 0.08 13.1 1.5 3.7 3 0 0 3 3 3 2 GAT domain TraH PF06122.9 NM_001037501.2_2 - 0.36 9.9 4.2 4.6 6.3 0.2 2.3 2 0 0 2 2 2 0 Conjugative relaxosome accessory transposon protein PWWP PF00855.15 NM_017984.4_3 - 5.5e-17 61.9 0.0 5.5e-17 61.9 0.0 2.5 2 0 0 2 2 2 1 PWWP domain zf-CW PF07496.13 NM_017984.4_3 - 1.1e-13 50.9 5.9 2.6e-13 49.7 5.9 1.7 1 0 0 1 1 1 1 CW-type Zinc Finger CM2 PF03021.12 NM_017984.4_3 - 0.2 11.3 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 Influenza C virus M2 protein Fasciclin PF02469.20 NM_001286667.1_2 - 1.5e-105 348.4 0.1 4e-28 98.1 0.0 4.2 4 0 0 4 4 4 4 Fasciclin domain zf-C4 PF00105.16 NM_001282451.1_3 - 1.4e-30 105.4 12.3 2.3e-30 104.7 12.3 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001282451.1_3 - 2.2e-29 102.4 0.0 3e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor WD40 PF00400.30 NM_032271.2_1 - 2.2e-29 100.9 24.6 3.3e-08 33.9 0.8 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat WD40_like PF17005.3 NM_032271.2_1 - 1.9e-06 27.3 0.8 3.3e-06 26.5 0.8 1.4 1 0 0 1 1 1 1 WD40-like domain zf-RING_UBOX PF13445.4 NM_032271.2_1 - 6.1e-06 26.0 8.9 2.6e-05 24.0 8.9 2.2 1 0 0 1 1 1 1 RING-type zinc-finger Sina PF03145.14 NM_032271.2_1 - 3.2e-05 23.9 10.0 0.0018 18.1 0.5 2.4 1 1 1 2 2 2 2 Seven in absentia protein family zf-TRAF PF02176.16 NM_032271.2_1 - 3.5e-05 24.3 6.0 3.5e-05 24.3 6.0 2.5 2 0 0 2 2 1 1 TRAF-type zinc finger zf-C3HC4 PF00097.23 NM_032271.2_1 - 5.2e-05 22.9 10.3 5.2e-05 22.9 10.3 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_032271.2_1 - 6.1e-05 22.7 14.4 6.1e-05 22.7 14.4 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PKcGMP_CC PF16808.3 NM_032271.2_1 - 0.00036 20.2 1.1 0.0097 15.6 0.0 2.4 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Nup160 PF11715.6 NM_032271.2_1 - 0.0005 18.7 1.7 0.0059 15.2 0.3 2.7 2 1 1 3 3 3 1 Nucleoporin Nup120/160 zf-C3HC4_4 PF15227.4 NM_032271.2_1 - 0.0005 20.0 7.8 0.0005 20.0 7.8 2.2 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 NM_032271.2_1 - 0.00097 18.8 11.9 0.00097 18.8 11.9 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF4164 PF13747.4 NM_032271.2_1 - 0.012 15.7 2.7 0.02 15.0 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) DUF16 PF01519.14 NM_032271.2_1 - 0.061 13.7 1.3 0.14 12.6 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 Tropomyosin_1 PF12718.5 NM_032271.2_1 - 0.071 13.1 2.7 0.11 12.5 2.7 1.2 1 0 0 1 1 1 0 Tropomyosin like Filament PF00038.19 NM_032271.2_1 - 0.12 11.9 2.2 0.16 11.4 2.2 1.1 1 0 0 1 1 1 0 Intermediate filament protein DUF1640 PF07798.9 NM_032271.2_1 - 0.15 11.9 1.7 0.26 11.2 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) zf-RING_5 PF14634.4 NM_032271.2_1 - 0.54 10.1 24.0 0.026 14.3 13.9 3.0 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.4 NM_032271.2_1 - 2.1 8.1 18.0 0.076 12.8 8.9 2.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-Nse PF11789.6 NM_032271.2_1 - 3.6 7.3 10.4 1.3 8.8 5.8 2.4 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Peptidase_M14 PF00246.22 NM_001199775.1_2 - 5.8e-174 577.5 0.2 2.3e-84 283.5 0.0 3.7 3 1 0 3 3 3 3 Zinc carboxypeptidase CarboxypepD_reg PF13620.4 NM_001199775.1_2 - 1.6e-37 127.5 12.5 1.6e-13 50.5 1.2 3.3 3 0 0 3 3 3 3 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 NM_001199775.1_2 - 4.5e-19 68.1 7.9 2.3e-08 33.8 0.2 3.3 3 0 0 3 3 3 3 CarboxypepD_reg-like domain PEGA PF08308.9 NM_001199775.1_2 - 4.1e-06 26.5 0.1 0.024 14.4 0.0 2.9 3 0 0 3 3 3 2 PEGA domain AstE_AspA PF04952.12 NM_001199775.1_2 - 0.0032 16.5 0.1 0.036 13.0 0.0 2.1 2 0 0 2 2 2 1 Succinylglutamate desuccinylase / Aspartoacylase family fn3_3 PF14686.4 NM_001199775.1_2 - 0.11 12.1 1.7 9.9 5.9 0.1 2.7 2 0 0 2 2 2 0 Polysaccharide lyase family 4, domain II Clusterin PF01093.15 NM_001323981.1_1 - 0.07 12.0 3.6 0.095 11.6 3.6 1.1 1 0 0 1 1 1 0 Clusterin MFS_1 PF07690.14 NM_001323981.1_2 - 1.9e-31 109.2 53.0 2.2e-24 85.9 24.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DEP PF00610.19 NM_139160.2_2 - 4.5e-18 64.9 0.1 3.5e-17 62.1 0.1 2.3 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Chlam_OMP PF01308.15 NM_001286796.1_1 - 0.22 10.1 0.2 0.33 9.5 0.2 1.2 1 0 0 1 1 1 0 Chlamydia major outer membrane protein Methyltransf_PK PF05891.10 NM_001286796.1_2 - 3.3e-93 311.1 0.0 4e-93 310.8 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.4 NM_001286796.1_2 - 3.6e-12 46.7 0.0 8.3e-12 45.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001286796.1_2 - 1.1e-10 41.8 0.0 1.8e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_001286796.1_2 - 6.4e-09 36.3 0.0 1e-08 35.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.16 NM_001286796.1_2 - 0.00031 19.9 0.0 0.00045 19.4 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_31 PF13847.4 NM_001286796.1_2 - 0.00036 20.2 0.0 0.00056 19.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 NM_001286796.1_2 - 0.00045 19.5 0.0 0.00065 19.0 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.4 NM_001286796.1_2 - 0.0012 18.6 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain bZIP_1 PF00170.19 NM_001267570.1_3 - 1.8e-20 72.6 9.8 3.1e-20 71.9 9.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001267570.1_3 - 7.8e-07 29.0 11.2 1.3e-06 28.3 11.2 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001267570.1_3 - 0.012 16.0 6.3 0.02 15.3 6.3 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor PTPLA PF04387.12 NM_001321903.1_2 - 2.3e-28 98.9 12.5 1.5e-21 76.7 4.9 2.7 2 0 0 2 2 2 2 Protein tyrosine phosphatase-like protein, PTPLA RhoGAP PF00620.25 NM_001092.4_3 - 1.6e-47 161.0 0.0 3.9e-47 159.8 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain RhoGEF PF00621.18 NM_001092.4_3 - 8.2e-32 110.8 2.3 1.5e-31 110.0 2.3 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 NM_001092.4_3 - 9e-10 38.9 4.1 3.3e-09 37.1 1.2 2.8 2 1 0 2 2 2 1 PH domain C2 PF00168.28 NM_001092.4_3 - 1.9e-06 28.0 0.1 3.9e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 C2 domain PH_10 PF15411.4 NM_001092.4_3 - 0.084 13.0 0.1 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Phage_antiter_Q PF06323.9 NM_001092.4_3 - 0.15 11.4 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Phage antitermination protein Q GAGE PF05831.9 NM_001097596.2_2 - 0.044 14.1 0.0 0.062 13.7 0.0 1.2 1 0 0 1 1 1 0 GAGE protein GAGE PF05831.9 NM_001097596.2_3 - 5.1e-05 23.6 7.9 7.5e-05 23.1 7.9 1.2 1 0 0 1 1 1 1 GAGE protein SH3_9 PF14604.4 NM_001290298.1_1 - 4.1e-37 125.7 0.6 2.2e-14 52.9 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 NM_001290298.1_1 - 1.2e-35 120.7 0.4 2.3e-10 39.8 0.0 3.6 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 NM_001290298.1_1 - 1.5e-28 98.1 0.2 6e-12 44.9 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 NM_001290298.1_1 - 5.4e-21 73.9 0.3 1.3e-20 72.7 0.3 1.6 1 0 0 1 1 1 1 Sorbin homologous domain Tubulin PF00091.23 NM_001320509.1_2 - 2e-65 220.6 0.0 3.3e-65 219.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_001320509.1_2 - 6.5e-47 158.7 0.1 1.2e-46 157.9 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 NM_001320509.1_2 - 0.00022 21.4 0.0 0.00056 20.1 0.0 1.6 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.4 NM_001320509.1_2 - 0.045 12.8 0.0 0.07 12.2 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.4 NM_001320509.1_2 - 0.071 12.7 0.1 0.17 11.4 0.0 1.6 2 0 0 2 2 2 0 Tubulin domain RRM_1 PF00076.20 NM_006328.3_2 - 7.8e-28 96.0 0.0 1.4e-15 56.8 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_006328.3_2 - 1.3e-07 31.2 0.0 0.008 15.6 0.1 2.6 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.13 NM_006328.3_2 - 0.015 15.1 0.2 0.038 13.9 0.1 1.6 2 0 0 2 2 2 0 DbpA RNA binding domain RRM_occluded PF16842.3 NM_006328.3_2 - 0.033 13.9 0.1 0.45 10.3 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif START PF01852.17 NM_001243476.2_3 - 1.7e-40 138.6 0.1 2.7e-40 137.9 0.1 1.3 1 0 0 1 1 1 1 START domain RhoGAP PF00620.25 NM_001243476.2_3 - 1.8e-36 125.1 2.5 3.1e-36 124.4 2.5 1.3 1 0 0 1 1 1 1 RhoGAP domain SAM_2 PF07647.15 NM_001243476.2_3 - 1.9e-05 24.6 0.0 4.9e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) 7tm_1 PF00001.19 NM_001098211.1_2 - 9e-68 228.3 0.3 1.3e-67 227.8 0.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_001098211.1_2 - 2.2e-06 27.5 11.7 8.4e-06 25.6 5.4 2.5 2 1 0 2 2 2 2 Olfactory receptor 7tm_4 PF13853.4 NM_030946.1_1 - 3.5e-49 167.9 17.1 4.2e-49 167.6 17.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_030946.1_1 - 1.6e-28 99.5 17.0 3.5e-28 98.5 17.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_030946.1_1 - 0.0031 16.8 17.3 0.013 14.8 17.3 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx RRM_1 PF00076.20 NM_004902.3_2 - 4.4e-41 138.4 0.0 8.8e-24 83.0 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.4 NM_004902.3_2 - 7.4e-28 97.3 0.5 2.2e-27 95.8 0.5 1.8 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.3 NM_004902.3_2 - 0.00051 19.7 0.0 0.028 14.2 0.0 3.1 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_5 PF13893.4 NM_004902.3_2 - 0.024 14.1 0.0 0.59 9.6 0.0 2.3 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.7 NM_004902.3_2 - 0.068 11.8 24.6 0.1 11.2 24.6 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 RRM_7 PF16367.3 NM_004902.3_2 - 0.096 12.7 0.0 0.32 11.0 0.0 1.9 1 0 0 1 1 1 0 RNA recognition motif CDC45 PF02724.12 NM_004902.3_2 - 0.72 8.0 19.3 1 7.4 19.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.15 NM_004902.3_2 - 2.1 6.9 10.8 2.9 6.4 10.8 1.1 1 0 0 1 1 1 0 Presenilin DDHD PF02862.15 NM_004902.3_2 - 3.2 7.7 7.8 3 7.8 6.3 1.7 2 0 0 2 2 2 0 DDHD domain NPR3 PF03666.11 NM_004902.3_2 - 9.3 4.8 15.2 14 4.2 15.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RRM_1 PF00076.20 NM_001171080.1_1 - 3.4e-09 36.3 0.0 6.9e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Septin PF00735.16 NM_001098811.1_2 - 1.9e-97 325.8 1.3 1.9e-97 325.8 1.3 1.6 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.21 NM_001098811.1_2 - 2.6e-06 27.3 0.0 6.2e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_001098811.1_2 - 0.00021 21.1 0.1 0.0068 16.2 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_22 PF13401.4 NM_001098811.1_2 - 0.00058 20.0 0.0 0.0016 18.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Roc PF08477.11 NM_001098811.1_2 - 0.00091 19.3 0.0 0.0021 18.2 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_001098811.1_2 - 0.002 18.4 0.2 0.0049 17.1 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain GTP_EFTU PF00009.25 NM_001098811.1_2 - 0.0038 16.7 5.7 3 7.2 0.6 3.2 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain Ras PF00071.20 NM_001098811.1_2 - 0.032 13.7 0.0 0.076 12.5 0.0 1.6 1 0 0 1 1 1 0 Ras family ABC_tran PF00005.25 NM_001098811.1_2 - 0.041 14.2 1.1 0.12 12.8 0.0 2.1 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.20 NM_001098811.1_2 - 0.052 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AIG1 PF04548.14 NM_001098811.1_2 - 0.1 11.8 0.0 0.1 11.8 0.0 2.2 2 0 0 2 2 2 0 AIG1 family Atg14 PF10186.7 NM_001098811.1_2 - 0.13 11.1 11.8 0.23 10.4 11.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IMD PF08397.9 NM_001098811.1_2 - 0.35 10.1 13.4 0.61 9.3 13.4 1.2 1 0 0 1 1 1 0 IRSp53/MIM homology domain AAA_32 PF13654.4 NM_001098811.1_2 - 0.79 8.3 16.6 5.5 5.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.4 NM_001098811.1_2 - 2.5 8.4 19.5 4.2 7.7 0.6 2.3 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.21 NM_001098811.1_2 - 4 7.3 6.7 7.5 6.4 0.1 2.8 2 1 0 2 2 2 0 Dynamin family DUF87 PF01935.15 NM_001098811.1_2 - 4.2 7.2 7.3 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 Exonuc_VII_L PF02601.13 NM_001098811.1_2 - 6 6.2 11.0 9.6 5.5 11.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6 PF04111.10 NM_001098811.1_2 - 6.5 5.9 16.0 13 5.0 16.0 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 pKID PF02173.15 NM_001177971.1_2 - 0.14 11.5 0.6 0.27 10.6 0.6 1.4 1 0 0 1 1 1 0 pKID domain VWA PF00092.26 NM_001177971.1_3 - 1.1e-77 260.1 0.1 7.5e-41 140.2 0.0 2.7 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_2 PF13519.4 NM_001177971.1_3 - 1.9e-31 108.8 0.0 2.1e-14 53.9 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.17 NM_001177971.1_3 - 2.6e-26 91.4 0.1 6.3e-26 90.2 0.1 1.7 1 0 0 1 1 1 1 LCCL domain VWA_CoxE PF05762.12 NM_001177971.1_3 - 0.0002 20.7 0.0 0.063 12.5 0.0 2.3 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein DUF1194 PF06707.9 NM_001177971.1_3 - 0.00035 19.7 0.1 0.48 9.5 0.1 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF1194) Rxt3 PF08642.8 NM_001177971.1_3 - 0.032 14.8 0.0 0.17 12.5 0.0 2.1 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 7tm_4 PF13853.4 NM_001005494.1_1 - 1.7e-47 162.3 21.0 2.3e-47 161.9 21.0 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005494.1_1 - 1.2e-23 83.6 23.6 3.7e-23 82.0 23.6 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Spo7_2_N PF15407.4 NM_001005494.1_3 - 0.048 13.2 0.0 0.097 12.2 0.0 1.4 1 0 0 1 1 1 0 Sporulation protein family 7 CTD_bind PF04818.11 NM_001286199.1_2 - 1.1e-17 64.4 0.1 3.2e-17 63.0 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.20 NM_001286199.1_2 - 1.3e-09 37.6 0.0 2.3e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer PF06495.9 NM_001286199.1_2 - 0.0003 20.8 23.8 0.0003 20.8 23.8 3.5 3 0 0 3 3 3 1 Fruit fly transformer protein DUF3525 PF12039.6 NM_001286199.1_2 - 0.025 13.2 0.2 0.042 12.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) RRM_occluded PF16842.3 NM_001286199.1_2 - 0.15 11.8 0.0 0.33 10.7 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif CTNNB1_binding PF08347.9 NM_001166119.1_2 - 7.4e-53 179.6 6.8 7.4e-53 179.6 6.8 1.7 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 NM_001166119.1_2 - 2.2e-21 75.9 0.7 2.2e-21 75.9 0.7 2.5 4 0 0 4 4 4 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_001166119.1_2 - 5.8e-08 33.1 3.0 7.1e-08 32.8 0.8 2.2 2 0 0 2 2 2 1 HMG-box domain Pkinase_Tyr PF07714.15 NM_001321363.1_2 - 1.4e-21 76.8 0.1 2.8e-21 75.9 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001321363.1_2 - 3e-20 72.5 0.1 7.3e-20 71.3 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Peptidase_C48 PF02902.17 NM_001308045.1_1 - 6.2e-22 78.4 2.7 2.2e-15 57.0 0.7 2.3 1 1 1 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain DEK_C PF08766.9 NM_001308045.1_1 - 0.026 14.3 0.0 0.062 13.1 0.0 1.6 1 0 0 1 1 1 0 DEK C terminal domain Aa_trans PF01490.16 NM_138570.3_2 - 6.8e-53 179.7 37.3 8.4e-53 179.4 37.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CCDC14 PF15254.4 NM_022757.4_2 - 0 1340.8 44.8 0 1310.8 40.3 2.0 1 1 1 2 2 2 2 Coiled-coil domain-containing protein 14 Zip PF02535.20 NM_001128225.2_3 - 2.6e-52 178.0 7.1 5.2e-39 134.3 2.7 2.1 1 1 1 2 2 2 2 ZIP Zinc transporter ISK_Channel PF02060.13 NM_001127668.3_1 - 1.1e-61 205.8 0.0 1.6e-61 205.3 0.0 1.2 1 0 0 1 1 1 1 Slow voltage-gated potassium channel Tubulin PF00091.23 NM_016262.4_1 - 1.1e-64 218.2 0.0 1.6e-64 217.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_016262.4_1 - 4.5e-30 104.3 0.0 7.7e-30 103.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.4 NM_016262.4_1 - 0.00067 18.8 0.0 0.00098 18.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.4 NM_016262.4_1 - 0.0039 16.8 0.0 0.0068 16.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain DUF4024 PF13216.4 NM_016262.4_3 - 0.37 10.6 3.3 1.2 9.0 3.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4024) Cullin PF00888.20 NM_001257198.1_3 - 1.2e-222 740.8 8.9 1.4e-222 740.5 8.9 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 NM_001257198.1_3 - 5e-27 93.6 1.1 5e-27 93.6 1.1 2.0 2 0 0 2 2 2 1 Cullin protein neddylation domain Kelch_1 PF01344.23 NM_001292007.1_1 - 1.2e-71 235.9 21.6 4.2e-14 51.7 0.1 6.9 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.4 NM_001292007.1_1 - 6.8e-40 134.0 4.9 5.8e-08 32.6 0.0 6.5 4 1 2 6 6 6 6 Kelch motif Kelch_3 PF13415.4 NM_001292007.1_1 - 4.1e-29 100.1 9.3 6.9e-06 26.1 0.1 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.4 NM_001292007.1_1 - 8.4e-28 96.0 2.8 1.1e-06 28.4 0.0 6.5 4 2 2 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_001292007.1_1 - 5.9e-27 92.5 9.2 0.0001 22.0 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Trypsin PF00089.24 NM_183378.2_1 - 3.7e-130 432.3 0.3 1.6e-65 220.9 0.0 2.2 2 0 0 2 2 2 2 Trypsin CUB PF00431.18 NM_183378.2_1 - 7.8e-44 148.4 0.0 2.8e-22 79.0 0.1 4.6 4 1 0 4 4 4 4 CUB domain DUF1986 PF09342.9 NM_183378.2_1 - 1.8e-17 63.6 0.3 3.4e-09 37.0 0.1 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_183378.2_1 - 1.5e-11 45.3 0.0 2.5e-05 25.0 0.0 3.0 2 1 0 2 2 2 2 Trypsin-like peptidase domain Mon1 PF03164.12 NM_001322478.1_3 - 0.066 12.1 0.1 4.5 6.1 0.0 2.3 2 0 0 2 2 2 0 Trafficking protein Mon1 DUF4642 PF15484.4 NM_001316317.1_2 - 2.3e-60 203.2 1.1 3.1e-60 202.8 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4642) Lectin_C PF00059.19 NM_001244755.1_2 - 2.2e-15 57.2 0.0 3.5e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain zf-H2C2_2 PF13465.4 NM_001145082.2_2 - 7.7e-63 206.2 76.7 1.2e-08 34.8 0.7 11.3 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001145082.2_2 - 8.9e-37 123.4 80.7 2.9e-06 27.3 1.1 10.7 10 0 0 10 10 10 10 Zinc finger, C2H2 type KRAB PF01352.25 NM_001145082.2_2 - 1.5e-23 82.1 0.3 2.6e-23 81.3 0.3 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001145082.2_2 - 5.3e-20 70.2 77.7 0.0037 17.8 0.6 11.0 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001145082.2_2 - 1.1e-08 34.6 58.6 0.044 13.6 0.2 9.4 10 0 0 10 10 10 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001145082.2_2 - 1.7e-08 34.3 55.3 0.01 15.8 2.4 6.8 2 2 7 9 9 9 8 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_001145082.2_2 - 0.0012 19.5 42.2 0.53 10.9 1.7 5.5 1 1 3 5 5 5 3 zinc-ribbon family C1_4 PF07975.10 NM_001145082.2_2 - 0.0029 17.7 48.3 0.46 10.7 1.2 6.7 4 1 1 6 6 6 4 TFIIH C1-like domain XPA_N PF01286.16 NM_001145082.2_2 - 0.23 11.4 52.0 2.4 8.1 0.1 9.8 10 0 0 10 10 10 0 XPA protein N-terminal zf-C2H2_jaz PF12171.6 NM_001145082.2_2 - 0.25 11.6 53.4 0.079 13.2 0.3 8.9 10 0 0 10 10 9 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 NM_001145082.2_2 - 0.74 9.7 37.2 6.4 6.7 1.4 8.5 1 1 8 9 9 9 0 CpXC protein DBC1 PF14443.4 NM_001282960.1_1 - 1.9e-51 173.1 0.0 7.7e-51 171.1 0.0 2.2 1 0 0 1 1 1 1 DBC1 S1-like PF14444.4 NM_001282960.1_1 - 2.9e-32 110.4 0.8 5.2e-32 109.6 0.8 1.4 1 0 0 1 1 1 1 S1-like SAP PF02037.25 NM_001282960.1_1 - 5.6e-09 35.4 1.7 5.6e-09 35.4 1.7 2.2 2 0 0 2 2 2 1 SAP domain Tautomerase_2 PF14552.4 NM_001282960.1_1 - 0.03 14.3 0.0 0.12 12.3 0.0 2.0 1 0 0 1 1 1 0 Tautomerase enzyme Rad51 PF08423.9 NM_001164269.1_1 - 1.2e-114 381.8 0.0 1.6e-114 381.3 0.0 1.1 1 0 0 1 1 1 1 Rad51 HHH_5 PF14520.4 NM_001164269.1_1 - 1.2e-07 32.1 0.2 3e-07 30.9 0.2 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA_25 PF13481.4 NM_001164269.1_1 - 1.3e-07 31.3 0.0 2e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.19 NM_001164269.1_1 - 9.2e-06 25.2 0.1 1.5e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein SEA PF01390.18 NM_002456.5_1 - 7.9e-14 51.7 1.0 1.2e-13 51.1 1.0 1.3 1 0 0 1 1 1 1 SEA domain Collectrin PF16959.3 NM_002456.5_1 - 0.037 13.6 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 Renal amino acid transporter IncA PF04156.12 NM_002456.5_1 - 0.28 10.8 1.8 0.46 10.1 1.2 1.6 2 0 0 2 2 2 0 IncA protein PsbH PF00737.18 NM_002456.5_1 - 4.2 7.0 5.7 0.53 9.9 0.7 2.0 2 0 0 2 2 2 0 Photosystem II 10 kDa phosphoprotein Amino_oxidase PF01593.22 NM_153042.3_2 - 4.4e-83 279.9 0.1 2.5e-64 218.1 0.0 2.1 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 NM_153042.3_2 - 6e-12 45.5 0.1 1.5e-11 44.2 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain zf-CW PF07496.13 NM_153042.3_2 - 5.9e-10 38.9 2.6 5.9e-10 38.9 2.6 2.3 2 0 0 2 2 2 1 CW-type Zinc Finger Pyr_redox_2 PF07992.12 NM_153042.3_2 - 3.6e-08 32.9 0.4 8e-08 31.7 0.4 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.15 NM_153042.3_2 - 1e-07 31.3 0.1 1.6e-07 30.7 0.1 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.4 NM_153042.3_2 - 3.4e-07 29.6 2.8 5.9e-05 22.3 0.8 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 NM_153042.3_2 - 1e-06 27.6 0.3 7.8e-06 24.7 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.17 NM_153042.3_2 - 2.9e-06 26.7 0.1 1.5e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.25 NM_153042.3_2 - 6.6e-06 26.5 0.2 1.8e-05 25.1 0.1 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 NM_153042.3_2 - 3.1e-05 23.6 0.1 5.1e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.10 NM_153042.3_2 - 3.1e-05 23.1 0.1 5.3e-05 22.3 0.1 1.4 1 1 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.22 NM_153042.3_2 - 5.4e-05 22.3 0.4 8e-05 21.8 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.4 NM_153042.3_2 - 0.00024 21.0 0.2 0.0094 15.8 0.1 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_oxidored PF12831.5 NM_153042.3_2 - 0.0003 20.1 0.1 0.00047 19.5 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.20 NM_153042.3_2 - 0.00048 19.2 0.4 0.0008 18.5 0.4 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.17 NM_153042.3_2 - 0.0043 16.3 0.0 0.0091 15.2 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.19 NM_153042.3_2 - 0.0072 15.5 0.1 0.012 14.7 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.4 NM_153042.3_2 - 0.041 14.2 0.1 0.081 13.2 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding zf-RING_2 PF13639.4 NM_153042.3_2 - 0.046 13.9 5.8 0.14 12.3 5.8 1.9 1 0 0 1 1 1 0 Ring finger domain IlvN PF07991.10 NM_153042.3_2 - 0.053 13.0 0.1 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain zf-C3HC4 PF00097.23 NM_153042.3_2 - 0.2 11.4 3.8 0.6 9.9 3.8 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Gar1 PF04410.12 NM_018983.3_2 - 3.2e-38 130.8 0.0 4.5e-38 130.3 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region DUF2610 PF11020.6 NM_018983.3_3 - 0.092 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2610) Cu2_monoox_C PF03712.13 NM_001319943.1_1 - 5.3e-42 142.9 0.2 1e-41 142.0 0.2 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain NHL PF01436.19 NM_001319943.1_1 - 6.6e-26 88.9 7.7 2.2e-06 27.3 0.2 5.7 5 0 0 5 5 5 4 NHL repeat Cu2_monooxygen PF01082.18 NM_001319943.1_1 - 3.5e-23 82.2 0.0 6.8e-23 81.2 0.0 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain SGL PF08450.10 NM_001319943.1_1 - 0.0028 17.2 0.0 1.4 8.3 0.0 3.4 3 1 0 3 3 3 1 SMP-30/Gluconolaconase/LRE-like region Motilin_ghrelin PF04644.10 NM_001319943.1_1 - 0.074 12.8 2.0 0.18 11.6 2.0 1.6 1 0 0 1 1 1 0 Motilin/ghrelin DUF5118 PF17162.2 NM_001319943.1_2 - 0.099 12.3 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) DUF4564 PF15169.4 NM_001100407.2_2 - 6.9e-83 276.8 0.0 8.7e-83 276.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) DUF4517 PF15006.4 NM_001039140.2_2 - 8.1e-51 172.1 0.0 1.2e-50 171.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4517) Histone PF00125.22 NM_002107.4_3 - 1.1e-53 181.0 1.7 1.6e-53 180.5 1.7 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 NM_002107.4_3 - 0.0003 20.7 0.0 0.00062 19.7 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.4 NM_002107.4_3 - 0.0015 18.7 0.0 0.0025 18.0 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.3 NM_002107.4_3 - 0.036 14.5 2.1 0.071 13.6 2.1 1.4 1 0 0 1 1 1 0 PCNA-associated factor HD_4 PF13328.4 NM_001286451.1_3 - 9.8e-23 80.5 0.2 1.4e-22 79.9 0.2 1.3 1 0 0 1 1 1 1 HD domain HD PF01966.20 NM_001286451.1_3 - 2.1e-05 24.6 0.8 7.6e-05 22.8 0.8 1.9 1 1 0 1 1 1 1 HD domain Ank_2 PF12796.5 NM_005178.4_2 - 2.1e-34 117.8 0.6 4.3e-13 49.5 0.1 3.9 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_005178.4_2 - 2.7e-29 100.6 9.6 7.8e-06 26.0 0.1 6.3 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.28 NM_005178.4_2 - 3.2e-28 96.8 12.8 1.6e-05 25.0 0.0 7.3 6 1 1 7 7 7 6 Ankyrin repeat Ank_4 PF13637.4 NM_005178.4_2 - 1.8e-27 95.2 1.8 2.1e-12 47.2 0.0 4.6 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_005178.4_2 - 2.9e-27 91.6 1.5 1.8e-05 24.6 0.0 7.0 7 0 0 7 7 7 6 Ankyrin repeat zf-C2H2_4 PF13894.4 NM_001271286.1_1 - 1.5e-07 31.5 35.1 0.012 16.2 2.5 6.9 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001271286.1_1 - 3.7e-07 30.1 27.9 0.0017 18.5 2.3 6.3 6 0 0 6 6 6 3 Zinc finger, C2H2 type CpXC PF14353.4 NM_001271286.1_1 - 3.2e-06 27.0 7.1 0.023 14.6 0.0 3.6 3 1 0 3 3 3 2 CpXC protein zf-C2H2_jaz PF12171.6 NM_001271286.1_1 - 0.0011 19.1 10.7 0.022 14.9 1.3 4.5 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.3 NM_001271286.1_1 - 0.014 15.7 22.5 0.81 10.1 0.2 5.1 4 2 1 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.13 NM_001271286.1_1 - 0.018 14.9 27.7 3.3 7.7 3.3 5.7 4 2 1 5 5 5 0 BED zinc finger zf-C2H2_2 PF12756.5 NM_001271286.1_1 - 0.042 14.0 20.6 0.48 10.6 0.8 4.8 2 2 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_aberr PF17017.3 NM_001271286.1_1 - 0.075 13.0 16.6 2.9 7.9 0.3 3.9 3 1 1 4 4 4 0 Aberrant zinc-finger zf-met PF12874.5 NM_001271286.1_1 - 1.3 9.4 12.3 1.9 8.8 0.3 4.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zinc_ribbon_2 PF13240.4 NM_001271286.1_1 - 8.2 6.2 11.6 16 5.3 0.4 4.3 4 0 0 4 4 4 0 zinc-ribbon domain HLH PF00010.24 NM_197957.3_2 - 3.2e-10 39.7 0.3 5.2e-10 39.0 0.3 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF1387 PF07139.9 NM_001282744.1_1 - 1.1e-124 416.0 13.4 1.1e-124 416.0 13.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1387) DUF1296 PF06972.9 NM_001282744.1_1 - 0.066 13.2 0.2 0.2 11.7 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) S_100 PF01023.17 NM_014624.3_3 - 2.4e-17 62.2 0.3 4e-17 61.5 0.3 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 NM_014624.3_3 - 6.7e-07 29.6 0.4 9.6e-07 29.1 0.4 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_014624.3_3 - 0.00047 19.4 0.5 0.0035 16.6 0.1 2.1 2 0 0 2 2 2 1 EF hand RHD_dimer PF16179.3 NM_173215.2_3 - 1.5e-26 92.3 0.1 1.5e-26 92.3 0.1 2.0 2 0 0 2 2 2 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.20 NM_173215.2_3 - 5.5e-20 71.9 0.1 5.5e-20 71.9 0.1 2.6 3 1 0 3 3 3 1 Rel homology DNA-binding domain 7tm_4 PF13853.4 NM_002551.3_1 - 2.5e-55 188.1 5.8 3e-55 187.8 5.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_002551.3_1 - 4.3e-20 71.9 13.7 9.4e-20 70.8 13.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_002551.3_1 - 5.4e-05 22.6 11.8 7.1e-05 22.2 11.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ECH_1 PF00378.18 NM_152342.3_1 - 1.2e-29 103.3 0.0 1.6e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Chromo PF00385.22 NM_152342.3_1 - 2.8e-15 55.8 1.9 5.3e-15 54.9 1.9 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ECH_2 PF16113.3 NM_152342.3_1 - 1.7e-11 44.1 0.0 2.5e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Mtf2_C PF14061.4 NM_152342.3_1 - 0.075 13.1 0.5 0.14 12.2 0.5 1.4 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 CAMSAP_CC1 PF17095.3 NM_001321508.1_2 - 0.28 10.9 3.4 0.49 10.1 3.4 1.3 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin Septin PF00735.16 NM_001321508.1_3 - 7.5e-73 245.1 0.5 1.1e-72 244.5 0.5 1.1 1 0 0 1 1 1 1 Septin WW PF00397.24 NM_001167989.1_2 - 3.9e-06 26.6 0.4 7e-06 25.8 0.4 1.5 1 0 0 1 1 1 1 WW domain zf-H2C2_2 PF13465.4 NM_001289049.1_2 - 5.6e-12 45.4 52.9 7.7e-05 22.8 3.7 8.8 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001289049.1_2 - 1.9e-11 43.6 65.9 3.1e-05 24.1 0.5 7.5 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001289049.1_2 - 4.5e-11 42.5 64.2 0.0053 17.3 0.4 8.7 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001289049.1_2 - 0.0036 17.4 24.7 0.53 10.5 4.6 6.7 5 1 1 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001289049.1_2 - 0.09 13.1 25.7 0.023 15.0 4.6 5.3 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_001289049.1_2 - 1.1 8.9 29.8 1.5 8.5 2.0 6.1 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 NM_001289049.1_2 - 2.7 8.2 22.1 2 8.7 5.2 3.4 1 1 2 3 3 3 0 C2H2-type zinc ribbon Tissue_fac PF01108.15 NM_207585.2_3 - 1.5e-24 85.7 1.1 5.6e-24 83.9 0.1 2.1 2 0 0 2 2 2 1 Tissue factor Interfer-bind PF09294.8 NM_207585.2_3 - 5.9e-17 61.8 0.1 1.1e-16 60.9 0.1 1.4 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III PrmA PF06325.11 NM_001290018.1_2 - 1.3e-07 31.2 0.2 3.6e-05 23.2 0.1 2.2 2 0 0 2 2 2 2 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.4 NM_001290018.1_2 - 7.4e-05 23.3 0.0 0.018 15.6 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.5 NM_001290018.1_2 - 0.00078 19.3 0.2 0.0024 17.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.13 NM_001290018.1_2 - 0.058 12.9 0.0 0.68 9.4 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical protein 95 tRNA-synt_2c PF01411.17 NM_001290018.1_2 - 0.084 11.2 0.1 0.12 10.7 0.1 1.1 1 0 0 1 1 1 0 tRNA synthetases class II (A) TrmK PF04816.10 NM_001290018.1_2 - 0.13 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase MTS PF05175.12 NM_001290018.1_2 - 0.18 11.2 0.1 1.3 8.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain Met_10 PF02475.14 NM_001290018.1_2 - 0.19 11.3 0.0 19 4.8 0.0 2.2 2 0 0 2 2 2 0 Met-10+ like-protein PCMT PF01135.17 NM_001290018.1_2 - 0.21 11.2 0.1 0.36 10.4 0.1 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 7tm_2 PF00002.22 NM_001308362.1_3 - 6.1e-39 133.7 14.0 8.9e-39 133.1 14.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 NM_001308362.1_3 - 3e-12 46.9 2.8 6.3e-12 45.8 2.8 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif TarH PF02203.13 NM_001308362.1_3 - 0.12 12.2 0.1 0.28 11.0 0.1 1.5 1 0 0 1 1 1 0 Tar ligand binding domain homologue 7tm_1 PF00001.19 NM_001308362.1_3 - 0.28 10.2 19.9 1.2 8.2 19.1 2.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF3566 PF12089.6 NM_001308362.1_3 - 7.4 6.8 15.1 0.25 11.6 6.7 2.4 2 1 0 2 2 2 0 Transmembrane domain of unknown function (DUF3566) DUF872 PF05915.10 NM_001009923.1_3 - 1.8e-18 66.7 0.5 3.2e-18 65.9 0.1 1.6 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF872) E2F_CC-MB PF16421.3 NM_198256.3_2 - 1.3e-31 108.7 0.5 2e-31 108.2 0.5 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.18 NM_198256.3_2 - 5.9e-23 80.5 0.2 1.5e-22 79.2 0.1 1.8 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.17 NM_198256.3_2 - 0.1 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Mtc PF03820.15 NM_001322980.1_2 - 2.2e-91 306.0 0.4 3e-91 305.6 0.4 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier Mtc PF03820.15 NM_001322980.1_3 - 6.1e-28 97.6 0.1 7.9e-28 97.3 0.1 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier CTP_transf_like PF01467.24 NM_001256433.2_3 - 1.3e-23 83.7 0.3 1.5e-12 47.8 0.0 2.7 2 1 0 2 2 2 2 Cytidylyltransferase-like DUF218 PF02698.15 NM_001256433.2_3 - 0.00011 22.1 0.0 0.00021 21.2 0.0 1.3 1 0 0 1 1 1 1 DUF218 domain FAD_syn PF06574.10 NM_001256433.2_3 - 0.0064 16.3 0.2 0.37 10.5 0.1 2.2 2 0 0 2 2 2 1 FAD synthetase EF-hand_8 PF13833.4 NM_003130.3_2 - 4e-14 52.0 0.2 1.5e-08 34.1 0.1 3.3 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_003130.3_2 - 5.8e-14 50.4 0.1 0.0016 17.7 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 NM_003130.3_2 - 2.2e-12 45.7 0.1 6e-05 22.5 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 NM_003130.3_2 - 1.8e-11 44.2 0.0 9e-06 25.9 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_003130.3_2 - 7.6e-09 34.6 0.2 0.00097 18.4 0.0 3.7 4 0 0 4 4 4 2 EF hand CEND1 PF15677.3 NM_001270734.1_2 - 0.0099 16.3 0.3 0.02 15.3 0.3 1.5 1 0 0 1 1 1 1 Cell cycle exit and neuronal differentiation protein 1 ARF7EP_C PF14949.4 NM_001195581.1_1 - 8.4e-35 119.4 12.9 1.4e-34 118.7 12.9 1.4 1 0 0 1 1 1 1 ARF7 effector protein C-terminus APP_E2 PF12925.5 NM_001136016.3_2 - 6.9e-74 247.5 20.3 1.1e-73 246.9 20.3 1.3 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 NM_001136016.3_2 - 1.1e-43 147.5 0.5 1.1e-43 147.5 0.5 2.1 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding Beta-APP PF03494.11 NM_001136016.3_2 - 1.1e-26 92.3 1.7 1.8e-26 91.6 1.7 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) APP_Cu_bd PF12924.5 NM_001136016.3_2 - 2.2e-25 89.0 7.9 2.9e-25 88.7 4.7 2.8 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.7 NM_001136016.3_2 - 2.5e-25 88.6 0.3 1e-24 86.7 0.3 2.1 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus Kunitz_BPTI PF00014.21 NM_001136016.3_2 - 1.8e-19 69.6 6.5 3.9e-19 68.5 6.5 1.6 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain SDA1 PF05285.10 NM_001136016.3_2 - 1.1 8.6 22.9 0.023 14.1 12.9 2.0 2 0 0 2 2 2 0 SDA1 Mod_r PF07200.11 NM_001136016.3_2 - 1.4 8.9 12.8 0.14 12.1 7.0 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Tissue_fac PF01108.15 NM_001289125.1_1 - 1.5e-24 85.7 1.1 5.8e-24 83.8 0.1 2.1 2 0 0 2 2 2 1 Tissue factor Interfer-bind PF09294.8 NM_001289125.1_1 - 6e-17 61.7 0.1 1.1e-16 60.9 0.1 1.4 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III Tim17 PF02466.17 NM_001167947.2_3 - 4.7e-28 97.4 1.9 6.5e-28 97.0 1.9 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Ferric_reduct PF01794.17 NM_001291929.1_1 - 7.5e-24 84.1 3.6 7.5e-24 84.1 3.6 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.10 NM_001291929.1_1 - 5.2e-23 81.8 0.0 1.2e-21 77.3 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.10 NM_001291929.1_1 - 7.9e-14 51.5 0.0 1.7e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.19 NM_001291929.1_1 - 0.11 13.0 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain PDZ PF00595.22 NM_001099682.2_3 - 7.5e-05 22.9 0.0 0.00013 22.1 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) CLN3 PF02487.15 NM_001286104.1_3 - 8.7e-136 452.9 12.5 1.8e-135 451.9 12.5 1.5 1 1 0 1 1 1 1 CLN3 protein LysM PF01476.18 NM_001284417.1_1 - 0.066 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 LysM domain Homeobox PF00046.27 NM_178120.4_1 - 3.9e-20 71.3 3.2 7.2e-20 70.4 3.2 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_178120.4_1 - 0.021 14.6 0.1 0.049 13.4 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain TPR_14 PF13428.4 NM_001288782.1_2 - 0.018 15.7 0.5 0.036 14.8 0.5 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001288782.1_2 - 0.08 13.0 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.15 NM_001288782.1_3 - 4.3e-28 95.0 5.7 0.0012 18.7 0.3 7.6 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001288782.1_3 - 2.7e-25 87.0 9.4 0.00012 21.7 0.1 6.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001288782.1_3 - 7.3e-19 67.7 10.9 2.7e-06 27.4 0.7 5.8 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001288782.1_3 - 1.1e-18 65.7 5.9 0.0031 17.5 0.1 6.0 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001288782.1_3 - 8e-15 54.2 1.8 0.031 15.0 0.0 7.5 4 2 4 8 8 8 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001288782.1_3 - 9.9e-14 50.1 8.4 0.0017 18.1 0.1 6.3 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001288782.1_3 - 3.8e-11 43.2 7.2 0.0054 17.1 0.0 4.7 3 2 3 6 6 5 4 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001288782.1_3 - 7.7e-11 42.4 1.6 0.0028 18.2 0.2 4.5 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001288782.1_3 - 1.4e-09 37.6 6.4 0.0029 17.7 0.4 7.1 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001288782.1_3 - 2.2e-07 31.0 8.0 1.1 10.0 0.4 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.4 NM_001288782.1_3 - 6.4e-07 28.7 1.8 0.00011 21.4 0.3 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001288782.1_3 - 7.2e-05 22.7 0.3 0.083 12.9 0.1 4.0 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001288782.1_3 - 0.00021 20.8 8.8 5.8 6.6 0.1 5.3 3 1 2 5 5 5 2 TPR repeat TPR_10 PF13374.4 NM_001288782.1_3 - 0.00087 19.0 9.1 0.086 12.6 0.8 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.12 NM_001288782.1_3 - 0.0057 16.0 4.8 0.25 10.6 0.2 2.8 1 1 2 3 3 3 2 Coatomer epsilon subunit PknG_TPR PF16918.3 NM_001288782.1_3 - 0.031 12.9 0.0 0.062 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat NARP1 PF12569.6 NM_001288782.1_3 - 0.034 12.9 4.1 0.5 9.1 0.1 2.9 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 DUF5112 PF17139.2 NM_001288782.1_3 - 0.036 13.4 0.3 0.036 13.4 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5112) ANAPC3 PF12895.5 NM_001288782.1_3 - 0.12 12.5 13.2 0.097 12.8 0.8 3.9 2 2 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Spectrin PF00435.19 NM_004010.3_2 - 3.3e-199 647.7 309.8 3e-17 62.9 1.8 26.1 23 3 1 25 25 25 22 Spectrin repeat CH PF00307.29 NM_004010.3_2 - 4.7e-44 148.9 3.0 6.3e-21 74.5 1.1 3.7 2 0 0 2 2 2 2 Calponin homology (CH) domain EF-hand_2 PF09068.9 NM_004010.3_2 - 6.3e-40 136.0 1.3 6.3e-40 136.0 1.3 3.7 3 0 0 3 3 3 1 EF hand EF-hand_3 PF09069.9 NM_004010.3_2 - 1.4e-39 134.2 0.0 1.6e-38 130.8 0.0 3.1 1 0 0 1 1 1 1 EF-hand ZZ PF00569.15 NM_004010.3_2 - 6.6e-19 67.3 4.2 1.7e-18 66.0 4.2 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type WW PF00397.24 NM_004010.3_2 - 6.6e-09 35.4 2.1 2.2e-08 33.8 2.1 2.0 1 0 0 1 1 1 1 WW domain CAMSAP_CH PF11971.6 NM_004010.3_2 - 1.3e-05 24.8 0.0 0.00016 21.3 0.0 2.7 2 0 0 2 2 2 1 CAMSAP CH domain Latarcin PF10279.7 NM_004010.3_2 - 3.5e-05 24.0 4.3 0.55 10.5 0.0 8.6 10 3 0 10 10 10 1 Latarcin precursor DinB_2 PF12867.5 NM_004010.3_2 - 3.1 8.2 13.1 2.1 8.8 0.0 6.0 6 0 0 6 6 6 0 DinB superfamily Vac_Fusion PF02346.14 NM_004010.3_2 - 7.8 6.1 7.3 1.9 8.1 0.4 4.0 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 zf-C2H2 PF00096.24 NM_001193328.1_1 - 1.3e-19 69.3 31.9 0.00021 21.4 0.6 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001193328.1_1 - 4.2e-12 45.8 26.9 1.5e-05 25.1 0.3 4.9 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001193328.1_1 - 1.7e-11 43.8 31.1 0.022 15.4 1.9 5.9 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_8 PF15909.3 NM_001193328.1_1 - 5e-05 23.4 7.3 5e-05 23.4 7.3 2.5 1 1 2 3 3 3 2 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.3 NM_001193328.1_1 - 0.023 14.7 3.3 0.051 13.6 0.4 2.3 1 1 1 2 2 2 0 Aberrant zinc-finger Zn-ribbon_8 PF09723.8 NM_001193328.1_1 - 0.12 12.4 11.1 3.4 7.8 0.1 4.0 3 1 0 3 3 3 0 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001193328.1_1 - 0.13 12.5 0.1 0.13 12.5 0.1 4.7 5 0 0 5 5 4 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 NM_001193328.1_1 - 0.16 11.9 6.2 5.1 7.0 0.0 3.7 1 1 2 3 3 3 0 CpXC protein zf-C2HC_2 PF13913.4 NM_001193328.1_1 - 0.16 11.7 29.2 0.17 11.7 1.2 6.1 6 0 0 6 6 6 0 zinc-finger of a C2HC-type zf-met PF12874.5 NM_001193328.1_1 - 0.4 11.0 20.4 0.52 10.6 0.1 5.5 5 0 0 5 5 5 0 Zinc-finger of C2H2 type FOXP-CC PF16159.3 NM_001193328.1_1 - 1.6 9.3 5.9 1 9.9 0.3 2.7 2 1 1 3 3 2 0 FOXP coiled-coil domain zf-Sec23_Sec24 PF04810.13 NM_001193328.1_1 - 5.9 6.9 12.8 13 5.8 0.1 4.5 5 0 0 5 5 5 0 Sec23/Sec24 zinc finger zf-TRAF PF02176.16 NM_001193328.1_1 - 8 7.1 20.5 0.26 11.9 4.0 4.0 4 0 0 4 4 4 0 TRAF-type zinc finger zf-RING_2 PF13639.4 NM_194460.2_2 - 8.8e-13 48.2 5.8 8.8e-13 48.2 5.8 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_194460.2_2 - 1.4e-09 37.5 5.5 1.4e-09 37.5 5.5 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 NM_194460.2_2 - 1.5e-07 30.8 0.8 1.5e-07 30.8 0.8 1.8 2 0 0 2 2 2 1 RING-like zinc finger zinc_ribbon_9 PF14369.4 NM_194460.2_2 - 2.3e-07 30.8 5.7 2.3e-07 30.8 5.7 2.8 3 0 0 3 3 3 1 zinc-ribbon zf-C3HC4 PF00097.23 NM_194460.2_2 - 2.5e-06 27.1 3.4 2.5e-06 27.1 3.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_194460.2_2 - 3.9e-06 26.9 8.0 3.9e-06 26.9 8.0 2.0 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 NM_194460.2_2 - 6.4e-06 26.0 3.8 7.8e-06 25.7 1.5 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_194460.2_2 - 1.7e-05 24.5 1.8 1.7e-05 24.5 1.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_194460.2_2 - 2e-05 24.3 3.1 2e-05 24.3 3.1 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 NM_194460.2_2 - 4.7e-05 23.2 1.9 0.00013 21.8 1.9 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 NM_194460.2_2 - 0.00086 19.0 7.3 0.00086 19.0 7.3 2.7 2 1 1 3 3 2 1 Prokaryotic RING finger family 4 zf-RING-like PF08746.9 NM_194460.2_2 - 0.034 14.3 3.0 0.098 12.9 3.0 1.8 1 0 0 1 1 1 0 RING-like domain zf-Nse PF11789.6 NM_194460.2_2 - 0.085 12.6 1.1 0.18 11.5 1.1 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Rad50_zn_hook PF04423.12 NM_194460.2_2 - 0.41 10.4 0.0 0.41 10.4 0.0 2.9 3 0 0 3 3 3 0 Rad50 zinc hook motif Zn_ribbon_17 PF17120.3 NM_194460.2_2 - 0.87 9.1 13.5 0.046 13.2 2.9 2.5 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type HypA PF01155.17 NM_194460.2_2 - 2.9 7.8 6.1 4 7.4 0.5 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.10 NM_194460.2_2 - 4.1 7.3 8.0 6.9 6.6 0.4 2.7 2 1 0 2 2 2 0 zinc-ribbons FGF PF00167.16 NM_001257211.1_3 - 5.1e-39 133.1 0.0 1.4e-38 131.7 0.0 1.7 2 0 0 2 2 2 1 Fibroblast growth factor Fascin PF06268.11 NM_001257211.1_3 - 0.076 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Fascin domain Nse4_C PF08743.8 NM_001008394.2_3 - 1.1e-28 99.1 0.0 2.6e-28 98.0 0.0 1.6 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.4 NM_001008394.2_3 - 3e-14 52.7 1.0 6.1e-14 51.7 1.0 1.5 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Mucin15 PF15672.3 NM_001195256.1_1 - 4.3e-05 23.0 0.0 4.3e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 Cell-membrane associated Mucin15 SET PF00856.26 NM_018489.2_1 - 3e-21 76.4 1.8 6.4e-21 75.3 0.2 2.6 2 0 0 2 2 2 1 SET domain BAH PF01426.16 NM_018489.2_1 - 1.1e-19 70.3 0.1 2.8e-19 69.0 0.1 1.8 1 0 0 1 1 1 1 BAH domain Bromodomain PF00439.23 NM_018489.2_1 - 2.7e-15 56.1 0.0 7.1e-15 54.7 0.0 1.7 1 0 0 1 1 1 1 Bromodomain PHD PF00628.27 NM_018489.2_1 - 2.9e-06 27.0 13.4 2.9e-06 27.0 13.4 2.9 2 0 0 2 2 2 1 PHD-finger Septin PF00735.16 NM_052838.4_2 - 4.5e-121 403.3 0.0 5.9e-121 402.9 0.0 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 NM_052838.4_2 - 4.2e-08 33.1 0.0 8.6e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_052838.4_2 - 3.9e-07 30.0 0.1 2.7e-05 24.0 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_052838.4_2 - 7.3e-06 25.5 0.9 0.05 13.0 0.0 2.5 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain AIG1 PF04548.14 NM_052838.4_2 - 0.0096 15.1 0.0 0.019 14.2 0.0 1.5 1 0 0 1 1 1 1 AIG1 family AAA_23 PF13476.4 NM_052838.4_2 - 0.013 15.9 0.0 0.13 12.6 0.0 2.1 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.21 NM_052838.4_2 - 0.014 15.3 0.0 8.8 6.2 0.0 3.1 3 0 0 3 3 3 0 Dynamin family AAA_22 PF13401.4 NM_052838.4_2 - 0.023 14.8 0.5 0.18 11.9 0.0 2.5 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.4 NM_052838.4_2 - 0.024 14.9 0.5 0.086 13.1 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain Roc PF08477.11 NM_052838.4_2 - 0.027 14.6 0.0 0.049 13.7 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.4 NM_052838.4_2 - 0.035 13.7 0.0 0.07 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ras PF00071.20 NM_052838.4_2 - 0.081 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Ras family ABC_tran PF00005.25 NM_052838.4_2 - 0.087 13.2 0.1 0.24 11.8 0.0 1.8 2 0 0 2 2 1 0 ABC transporter IIGP PF05049.11 NM_052838.4_2 - 0.14 11.1 0.0 0.36 9.7 0.0 1.7 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Pet20 PF08692.8 NM_052838.4_2 - 0.17 12.4 0.1 0.54 10.8 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial protein Pet20 SUIM_assoc PF16619.3 NM_052838.4_2 - 3.9 7.5 5.8 12 5.9 5.8 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CP2 PF04516.13 NM_198174.2_3 - 2e-78 262.7 0.0 3e-78 262.2 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor TMEM169 PF15052.4 NM_001142312.1_1 - 2.2e-62 208.8 7.7 4.2e-62 207.9 7.7 1.5 1 0 0 1 1 1 1 TMEM169 protein family TIP49 PF06068.11 NM_006666.2_3 - 5.8e-184 611.5 3.2 7e-184 611.2 3.2 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.27 NM_006666.2_3 - 6e-09 36.3 0.4 2.2e-05 24.8 0.1 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 NM_006666.2_3 - 6.9e-07 29.7 0.1 7.5e-06 26.3 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain DnaB_C PF03796.13 NM_006666.2_3 - 4.2e-06 26.1 0.2 7.2e-06 25.3 0.2 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain RuvB_N PF05496.10 NM_006666.2_3 - 5.8e-06 25.6 0.3 0.0018 17.5 0.1 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 NM_006666.2_3 - 2.3e-05 24.3 0.2 0.0041 17.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 NM_006666.2_3 - 0.0002 21.5 0.4 0.21 11.7 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.4 NM_006666.2_3 - 0.00022 21.4 1.9 0.0019 18.4 1.9 2.3 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.24 NM_006666.2_3 - 0.00054 19.6 0.1 0.25 10.9 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.19 NM_006666.2_3 - 0.00061 19.1 1.1 0.01 15.1 0.3 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.4 NM_006666.2_3 - 0.0031 17.0 0.0 0.012 15.1 0.1 1.8 2 0 0 2 2 2 1 AAA domain ATPase PF06745.11 NM_006666.2_3 - 0.0032 16.7 0.0 0.0066 15.7 0.0 1.5 1 0 0 1 1 1 1 KaiC Zeta_toxin PF06414.10 NM_006666.2_3 - 0.0081 15.3 0.4 0.015 14.4 0.4 1.4 1 0 0 1 1 1 1 Zeta toxin DUF2075 PF09848.7 NM_006666.2_3 - 0.021 14.0 0.0 0.036 13.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.10 NM_006666.2_3 - 0.027 14.2 0.0 0.061 13.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.4 NM_006666.2_3 - 0.031 13.8 1.1 1.4 8.5 0.3 2.4 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.4 NM_006666.2_3 - 0.12 12.0 0.1 0.21 11.2 0.1 1.5 1 1 0 1 1 1 0 AAA domain MS_channel PF00924.16 NM_006666.2_3 - 0.12 11.8 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel AAA_29 PF13555.4 NM_006666.2_3 - 0.17 11.5 0.2 0.84 9.3 0.1 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain PhoH PF02562.14 NM_006666.2_3 - 0.76 9.1 4.3 0.47 9.8 0.4 2.4 3 0 0 3 3 3 0 PhoH-like protein zf-H2C2_2 PF13465.4 NM_001305037.1_2 - 2e-111 359.7 140.9 5.5e-09 35.9 2.2 18.2 18 0 0 18 18 18 17 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001305037.1_2 - 6.6e-80 259.2 169.2 7e-06 26.1 2.0 18.2 18 0 0 18 18 18 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001305037.1_2 - 1.7e-29 99.8 165.7 0.0066 17.0 1.5 18.7 19 0 0 19 19 19 16 C2H2-type zinc finger RVT_1 PF00078.25 NM_001305037.1_2 - 0.00072 19.0 0.1 0.0014 18.1 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) C1_4 PF07975.10 NM_001305037.1_2 - 0.0031 17.6 99.2 0.013 15.6 5.2 12.0 3 2 12 15 15 15 5 TFIIH C1-like domain zf-C2H2_6 PF13912.4 NM_001305037.1_2 - 0.0045 16.8 135.4 0.23 11.3 1.1 17.1 16 1 0 16 16 16 9 C2H2-type zinc finger BolA PF01722.16 NM_001305037.1_2 - 0.083 13.0 20.1 0.99 9.6 0.1 6.5 4 2 2 6 6 6 0 BolA-like protein Zn-ribbon_8 PF09723.8 NM_001305037.1_2 - 7.4 6.7 109.2 1.1 9.3 5.9 11.6 4 3 9 14 14 14 0 Zinc ribbon domain DUF4685 PF15737.3 NM_020950.1_2 - 1.9e-54 183.3 7.7 7.5e-54 181.4 7.7 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4685) UDG PF03167.17 NM_001243788.1_1 - 0.00017 21.5 0.1 0.00065 19.6 0.1 1.8 1 1 0 1 1 1 1 Uracil DNA glycosylase superfamily DUF4918 PF16265.3 NM_001243788.1_1 - 0.00041 19.8 0.0 0.0046 16.4 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4918) KRAB PF01352.25 NM_001267606.1_1 - 2e-23 81.6 0.2 3.6e-23 80.8 0.2 1.4 1 0 0 1 1 1 1 KRAB box DUF3534 PF12053.6 NM_001184786.1_1 - 1.2e-57 194.2 1.4 1.9e-57 193.5 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3534) PDZ PF00595.22 NM_001184786.1_1 - 8.9e-37 125.2 5.3 8e-16 58.0 0.2 3.6 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001184786.1_1 - 1.7e-13 50.5 0.5 1.8e-05 24.9 0.1 3.8 3 1 0 3 3 3 3 PDZ domain Hepar_II_III PF07940.11 NM_001322944.1_2 - 0.034 13.7 0.0 3.9 6.9 0.0 2.5 2 1 0 2 2 2 0 Heparinase II/III-like protein DUF4962 PF16332.3 NM_001322944.1_3 - 2.3e-07 29.6 3.9 2.3e-07 29.6 3.9 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4962) DUF1127 PF06568.9 NM_001177999.1_1 - 5.2 6.8 8.3 9.1 6.0 8.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) Na_Pi_cotrans PF02690.13 NM_001177999.1_3 - 1.5e-37 128.7 25.1 2.4e-23 82.7 10.2 2.4 2 0 0 2 2 2 2 Na+/Pi-cotransporter PDEase_I PF00233.17 NM_001258313.1_2 - 2.6e-81 272.7 4.8 5e-81 271.8 4.8 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.10 NM_001258313.1_2 - 5.8e-32 109.2 0.1 1.1e-31 108.3 0.1 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal Rsm22 PF09243.8 NM_001029991.1_3 - 1.4e-53 181.8 0.0 2e-53 181.3 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_11 PF08241.10 NM_001029991.1_3 - 8.7e-05 22.9 0.0 0.00025 21.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_001029991.1_3 - 0.00013 22.5 0.0 0.00039 21.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 NM_001029991.1_3 - 0.001 18.9 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_001029991.1_3 - 0.0016 19.0 0.0 0.013 16.1 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001029991.1_3 - 0.0083 15.8 0.0 0.036 13.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain RRM_1 PF00076.20 NM_005066.2_1 - 4.2e-30 103.2 0.1 1.3e-14 53.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.9 NM_005066.2_1 - 5.5e-28 96.7 1.0 1.1e-27 95.7 1.0 1.6 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.3 NM_005066.2_1 - 0.0011 18.9 0.0 0.0059 16.6 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif adh_short PF00106.23 NM_203315.2_1 - 5e-41 140.2 0.0 7e-41 139.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_203315.2_1 - 5.5e-25 88.2 0.0 8.4e-25 87.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_203315.2_1 - 2.4e-06 27.5 0.0 3.8e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.8 NM_203315.2_1 - 0.00063 19.1 0.0 0.0018 17.6 0.0 1.6 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) WT1 PF02165.13 NM_203315.2_1 - 0.0026 16.9 6.9 0.0038 16.4 6.9 1.2 1 0 0 1 1 1 1 Wilm's tumour protein CTD_bind PF04818.11 NM_001286194.1_1 - 1.1e-17 64.5 0.1 3.2e-17 63.0 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.20 NM_001286194.1_1 - 1.3e-09 37.6 0.0 2.3e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer PF06495.9 NM_001286194.1_1 - 0.0003 20.8 23.8 0.0003 20.8 23.8 2.9 2 0 0 2 2 2 1 Fruit fly transformer protein DUF3525 PF12039.6 NM_001286194.1_1 - 0.024 13.2 0.2 0.041 12.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) RRM_occluded PF16842.3 NM_001286194.1_1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif TUDOR PF00567.22 NM_032944.3_1 - 9.8e-24 83.6 0.0 2.6e-23 82.2 0.0 1.8 1 0 0 1 1 1 1 Tudor domain Pkinase PF00069.23 NM_032944.3_1 - 8.2e-18 64.6 0.0 2.6e-17 62.9 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_032944.3_1 - 5.8e-10 38.7 0.0 1.3e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Agenet PF05641.10 NM_032944.3_1 - 0.0024 18.2 0.1 0.0079 16.5 0.1 1.9 1 0 0 1 1 1 1 Agenet domain E1-E2_ATPase PF00122.18 NM_174958.2_3 - 6.2e-65 218.5 1.2 6.2e-65 218.5 1.2 2.3 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 NM_174958.2_3 - 3.1e-46 157.3 4.5 6e-46 156.3 4.5 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 NM_174958.2_3 - 1.1e-20 73.4 0.1 1.8e-20 72.7 0.1 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 NM_174958.2_3 - 6.6e-20 72.2 0.2 9.7e-19 68.4 0.2 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 NM_174958.2_3 - 3.7e-18 64.8 0.9 6.4e-18 64.0 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 NM_174958.2_3 - 2.7e-06 27.2 2.3 2.7e-06 27.2 1.1 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 NM_174958.2_3 - 0.00079 19.7 0.0 0.0025 18.1 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3106 PF11304.6 NM_174958.2_3 - 0.017 15.4 0.0 0.14 12.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) Peptidase_M10 PF00413.22 NM_022468.4_1 - 2.2e-49 167.2 0.0 3e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 NM_022468.4_1 - 4.6e-42 141.6 9.9 1.7e-14 53.3 0.4 5.2 5 0 0 5 5 5 4 Hemopexin PG_binding_1 PF01471.16 NM_022468.4_1 - 4.2e-11 42.7 0.0 8.3e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Peptidase_M66 PF10462.7 NM_022468.4_1 - 0.071 11.9 0.2 0.11 11.3 0.2 1.1 1 0 0 1 1 1 0 Peptidase M66 Astacin PF01400.22 NM_022468.4_1 - 0.14 11.6 0.1 0.28 10.7 0.1 1.4 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Metallopep PF12044.6 NM_022468.4_1 - 0.16 10.5 0.1 0.24 9.8 0.1 1.1 1 0 0 1 1 1 0 Putative peptidase family Spin-Ssty PF02513.15 NM_001282462.1_3 - 2.4e-34 116.7 5.0 9.8e-22 76.3 1.3 2.3 2 0 0 2 2 2 2 Spin/Ssty Family Branch PF02485.19 NM_001097636.1_3 - 3.6e-60 203.4 0.1 5.3e-60 202.8 0.1 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Shisa PF13908.4 NM_001272068.1_3 - 2.8e-42 145.0 11.2 5.8e-42 144.0 11.2 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator CD20 PF04103.13 NM_001146683.1_2 - 0.012 15.5 5.6 0.013 15.5 3.6 2.0 1 1 1 2 2 2 0 CD20-like family EAP30 PF04157.14 NM_001317192.1_1 - 7.4e-72 241.3 0.1 8.9e-72 241.0 0.1 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family EutK_C PF16365.3 NM_001317192.1_1 - 0.014 15.3 0.0 0.036 14.0 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilization protein EutK C-terminus Plasmid_RAQPRD PF09686.8 NM_001317192.1_1 - 0.17 12.0 0.6 0.35 11.0 0.1 1.7 2 0 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Sortilin-Vps10 PF15902.3 NM_002959.6_3 - 1.9e-112 376.2 0.9 2.4e-112 375.8 0.9 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.3 NM_002959.6_3 - 2.5e-36 125.5 3.2 3.8e-36 124.8 3.2 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR_6 PF15899.3 NM_002959.6_3 - 3.7e-20 69.8 21.2 0.0002 21.0 0.2 6.4 6 0 0 6 6 6 5 BNR-Asp box repeat BNR PF02012.18 NM_002959.6_3 - 0.00043 19.7 32.1 0.67 10.1 1.5 8.6 8 0 0 8 8 8 3 BNR/Asp-box repeat La PF05383.15 NM_001170804.1_2 - 2.6e-17 62.5 0.1 5e-17 61.6 0.1 1.5 1 0 0 1 1 1 1 La domain PX PF00787.22 NM_001267061.1_3 - 8e-16 57.9 0.4 2.4e-15 56.4 0.1 1.9 2 0 0 2 2 2 1 PX domain RA PF00788.21 NM_001267061.1_3 - 0.0028 18.1 0.1 0.0058 17.1 0.1 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain FERM_M PF00373.16 NM_001267061.1_3 - 0.012 15.9 0.6 0.12 12.7 0.2 2.5 2 1 1 3 3 3 0 FERM central domain Nod1 PF17114.3 NM_001267061.1_3 - 0.019 15.0 0.4 0.038 14.0 0.4 1.4 1 0 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 Ras_bdg_2 PF14847.4 NM_001267061.1_3 - 0.024 14.8 0.0 0.043 14.0 0.0 1.4 1 0 0 1 1 1 0 Ras-binding domain of Byr2 Vps16_N PF04841.11 NM_022575.3_1 - 7.5e-170 565.0 0.0 9.5e-170 564.6 0.0 1.1 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.10 NM_022575.3_1 - 5.4e-145 482.3 1.0 8.4e-145 481.6 1.0 1.3 1 0 0 1 1 1 1 Vps16, C-terminal region FliO PF04347.11 NM_022575.3_1 - 0.11 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Flagellar biosynthesis protein, FliO SRCR PF00530.16 NM_001254750.1_1 - 1.7e-63 211.2 23.6 1.9e-25 89.1 2.8 3.5 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 NM_001254750.1_1 - 4.4e-10 39.8 15.0 0.0061 16.9 2.1 3.6 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain TMEM154 PF15102.4 NM_001254750.1_1 - 0.015 15.1 0.5 0.028 14.2 0.5 1.4 1 0 0 1 1 1 0 TMEM154 protein family EF-hand_2 PF09068.9 NM_001256304.1_1 - 3.5e-35 120.7 1.6 7.5e-35 119.6 1.6 1.6 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.9 NM_001256304.1_1 - 1.7e-30 105.2 0.1 4.3e-30 103.9 0.1 1.7 1 0 0 1 1 1 1 EF-hand ZZ PF00569.15 NM_001256304.1_1 - 2.4e-09 36.7 10.5 5.2e-09 35.6 10.5 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.14 NM_001256304.1_1 - 0.0031 17.7 10.7 0.0066 16.6 10.7 1.6 1 0 0 1 1 1 1 C1 domain DUF342 PF03961.11 NM_001256304.1_1 - 0.0041 15.6 2.4 0.0073 14.8 2.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF342) SOGA PF11365.6 NM_001256304.1_1 - 0.027 15.4 7.2 0.099 13.6 7.2 2.0 1 0 0 1 1 1 0 Protein SOGA DUF4407 PF14362.4 NM_001256304.1_1 - 0.053 12.7 0.4 0.092 12.0 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CRISPR_Cse2 PF09485.8 NM_001256304.1_1 - 0.48 10.8 8.3 0.94 9.9 7.9 1.6 1 1 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) APG6 PF04111.10 NM_001256304.1_1 - 0.74 9.0 7.7 1.4 8.1 7.7 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 NM_001256304.1_1 - 1 9.0 9.2 2.4 7.8 9.2 1.6 1 0 0 1 1 1 0 IncA protein MerR-DNA-bind PF09278.9 NM_001256304.1_1 - 1.5 9.2 11.6 2.5 8.6 10.0 2.3 1 1 1 2 2 2 0 MerR, DNA binding GET2 PF08690.8 NM_001256304.1_1 - 2.4 7.6 6.5 3.1 7.2 0.3 2.8 2 0 0 2 2 2 0 GET complex subunit GET2 zf-H2C2_2 PF13465.4 NM_001172832.1_2 - 5.5e-85 276.2 65.1 1.8e-08 34.3 0.1 13.4 13 0 0 13 13 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001172832.1_2 - 3.1e-70 228.8 74.5 5.4e-07 29.6 0.9 13.0 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001172832.1_2 - 7.8e-34 113.3 77.3 0.00075 20.0 0.6 13.2 13 0 0 13 13 13 12 C2H2-type zinc finger KRAB PF01352.25 NM_001172832.1_2 - 1.2e-26 92.0 0.6 2.4e-26 91.0 0.6 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001172832.1_2 - 8e-12 44.7 60.0 0.016 15.0 0.3 12.7 13 0 0 13 13 13 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001172832.1_2 - 1.2e-08 34.8 61.3 0.04 13.9 3.8 8.2 1 1 9 11 11 11 9 Zinc ribbon domain C1_4 PF07975.10 NM_001172832.1_2 - 2.5e-06 27.5 50.2 0.92 9.7 0.5 8.7 2 2 6 9 9 9 8 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 NM_001172832.1_2 - 0.025 15.2 49.8 2.1 9.1 1.3 6.5 1 1 5 6 6 6 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_001172832.1_2 - 0.067 13.4 46.0 0.083 13.1 0.2 11.2 12 0 0 12 12 12 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_001172832.1_2 - 0.43 10.8 39.7 1.5 9.0 1.7 6.7 2 2 2 7 7 7 0 zinc-finger-containing domain MBD PF01429.17 NM_001172832.1_2 - 0.58 9.8 4.3 1.4e+02 2.1 0.1 4.9 3 2 1 5 5 5 0 Methyl-CpG binding domain DNA_RNApol_7kD PF03604.11 NM_001172832.1_2 - 4.2 7.0 53.4 2.5 7.7 0.1 11.3 12 0 0 12 12 11 0 DNA directed RNA polymerase, 7 kDa subunit FYVE PF01363.19 NM_001172832.1_2 - 4.3 7.4 56.5 2.9 8.0 0.6 6.7 1 1 3 5 5 5 0 FYVE zinc finger TMEM156 PF15106.4 NM_024943.2_1 - 5.8e-123 408.5 10.8 8.2e-123 408.0 10.8 1.2 1 0 0 1 1 1 1 TMEM156 protein family Marek_A PF02124.13 NM_024943.2_1 - 0.085 12.5 0.1 0.19 11.4 0.1 1.5 1 0 0 1 1 1 0 Marek's disease glycoprotein A ATP-synt_8 PF00895.18 NM_024943.2_1 - 2.6 8.4 5.8 1.1 9.7 1.3 2.6 2 0 0 2 2 2 0 ATP synthase protein 8 AIG1 PF04548.14 NM_001303630.1_1 - 4.5e-79 264.5 0.0 6.4e-79 264.0 0.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.21 NM_001303630.1_1 - 5.1e-08 32.9 0.0 8.6e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase WD40 PF00400.30 NM_001320546.1_3 - 1.1e-17 63.9 17.2 0.00055 20.6 0.1 10.4 10 0 0 10 10 10 4 WD domain, G-beta repeat Nsp3_PL2pro PF12124.6 NM_001320546.1_3 - 0.14 11.8 0.0 0.38 10.5 0.0 1.7 2 0 0 2 2 2 0 Coronavirus polyprotein cleavage domain Mito_carr PF00153.25 NM_001321544.1_1 - 2.4e-70 232.4 0.9 1.9e-24 85.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein COE1_DBD PF16422.3 NM_022659.3_2 - 6e-142 470.7 3.2 8.1e-142 470.2 3.2 1.1 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.3 NM_022659.3_2 - 1.9e-33 113.8 2.0 2.7e-27 94.1 0.3 2.4 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.22 NM_022659.3_2 - 1.2e-11 44.3 0.1 3.1e-11 43.1 0.1 1.7 1 0 0 1 1 1 1 IPT/TIG domain DAG1 PF05454.9 NM_001177637.2_2 - 5.7e-162 537.8 7.3 8.3e-162 537.2 7.3 1.2 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) TMEM154 PF15102.4 NM_001177637.2_2 - 0.0081 15.9 0.0 0.0081 15.9 0.0 1.8 2 0 0 2 2 2 1 TMEM154 protein family Thioredoxin PF00085.18 NM_001271581.1_2 - 6.3e-89 292.6 0.2 1.1e-23 83.0 0.3 5.2 5 0 0 5 5 5 5 Thioredoxin DnaJ PF00226.29 NM_001271581.1_2 - 2e-23 82.1 0.5 4.1e-23 81.1 0.5 1.6 1 0 0 1 1 1 1 DnaJ domain Thioredoxin_2 PF13098.4 NM_001271581.1_2 - 3.7e-13 49.8 2.1 0.00042 20.6 0.0 5.6 4 1 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_6 PF13848.4 NM_001271581.1_2 - 7.3e-12 45.5 0.1 9.9e-05 22.2 0.0 3.9 3 1 1 4 4 4 3 Thioredoxin-like domain Thioredoxin_8 PF13905.4 NM_001271581.1_2 - 3.9e-11 43.0 1.8 0.29 11.4 0.0 5.9 4 2 2 6 6 6 4 Thioredoxin-like Thioredoxin_7 PF13899.4 NM_001271581.1_2 - 2.4e-06 27.5 2.7 2.8 8.0 0.0 4.4 4 0 0 4 4 4 3 Thioredoxin-like Redoxin PF08534.8 NM_001271581.1_2 - 2.8e-05 23.7 0.7 0.084 12.4 0.0 2.9 3 0 0 3 3 3 2 Redoxin AhpC-TSA PF00578.19 NM_001271581.1_2 - 3.3e-05 23.7 1.4 0.9 9.3 0.0 4.2 4 0 0 4 4 4 2 AhpC/TSA family TraF PF13728.4 NM_001271581.1_2 - 0.045 13.5 0.4 1.6 8.4 0.0 3.1 3 0 0 3 3 3 0 F plasmid transfer operon protein FAM60A PF15396.4 NM_001135811.1_3 - 3.8e-81 272.0 10.2 5.7e-81 271.4 10.2 1.2 1 0 0 1 1 1 1 Protein Family FAM60A Tmemb_170 PF10190.7 NM_001304996.1_3 - 1e-23 83.6 4.1 1.8e-11 44.2 0.7 2.5 1 1 1 2 2 2 2 Putative transmembrane protein 170 PID PF00640.21 NM_016848.5_2 - 3.5e-48 163.1 0.0 4.9e-48 162.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.22 NM_016848.5_2 - 2.2e-16 59.5 0.0 3.6e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain EGF_CA PF07645.13 NM_001145110.1_3 - 2.4e-28 97.9 64.2 2.3e-11 43.6 6.9 10.1 9 2 1 10 10 5 5 Calcium-binding EGF domain VWC PF00093.16 NM_001145110.1_3 - 2.2e-18 66.2 63.0 6.5e-10 39.0 14.5 10.1 6 1 3 9 9 5 5 von Willebrand factor type C domain EGF_3 PF12947.5 NM_001145110.1_3 - 3.3e-13 49.4 40.1 9.2e-09 35.2 15.7 10.2 10 0 0 10 10 8 4 EGF domain cEGF PF12662.5 NM_001145110.1_3 - 1.7e-09 37.3 12.3 1.4e-07 31.2 3.3 10.2 11 0 0 11 11 10 5 Complement Clr-like EGF-like Laminin_G_2 PF02210.22 NM_001145110.1_3 - 3e-07 30.9 0.0 5.2e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.25 NM_001145110.1_3 - 7.4e-06 26.0 21.0 8.6e-05 22.6 8.4 11.3 11 1 0 11 11 6 6 EGF-like domain EGF_MSP1_1 PF12946.5 NM_001145110.1_3 - 2.8e-05 24.0 9.2 2.8e-05 24.0 9.2 7.8 8 0 0 8 8 8 3 MSP1 EGF domain 1 TILa PF12714.5 NM_001145110.1_3 - 0.00011 21.9 25.1 0.0012 18.6 7.6 10.6 8 4 2 10 10 7 4 TILa domain Laminin_G_3 PF13385.4 NM_001145110.1_3 - 0.00014 21.9 0.0 0.00024 21.1 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily hEGF PF12661.5 NM_001145110.1_3 - 0.00024 21.5 16.7 0.0022 18.5 6.0 12.0 11 0 0 11 11 10 4 Human growth factor-like EGF Laminin_G_1 PF00054.21 NM_001145110.1_3 - 0.00036 20.6 0.0 0.00078 19.5 0.0 1.6 1 1 0 1 1 1 1 Laminin G domain EGF_2 PF07974.11 NM_001145110.1_3 - 0.0078 16.4 11.1 0.0078 16.4 11.1 12.5 13 2 0 13 13 8 1 EGF-like domain CFC PF09443.8 NM_001145110.1_3 - 0.61 9.9 53.1 0.024 14.3 4.5 7.1 6 0 0 6 6 6 0 Cripto_Frl-1_Cryptic (CFC) MAGP PF05507.9 NM_001297710.1_1 - 3.9e-50 169.7 1.2 6.9e-50 168.8 1.2 1.4 1 0 0 1 1 1 1 Microfibril-associated glycoprotein (MAGP) Hormone_recep PF00104.28 NM_002135.4_2 - 1.2e-31 109.8 0.0 1.8e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_002135.4_2 - 9e-31 106.0 18.2 1.5e-30 105.3 18.2 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) CRAL_TRIO PF00650.18 NM_001257378.1_2 - 2.9e-37 127.7 0.0 3.9e-37 127.3 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.4 NM_001257378.1_2 - 1.5e-07 31.8 0.2 0.0012 19.2 0.0 2.3 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO_2 PF13716.4 NM_001257378.1_2 - 0.0024 17.9 0.0 0.0038 17.2 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.13 NM_001257378.1_3 - 0.0053 16.8 0.1 0.0098 15.9 0.1 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Glyco_transf_21 PF13506.4 NM_003358.2_1 - 1.3e-58 197.2 0.0 1.8e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.4 NM_003358.2_1 - 4.5e-24 85.5 0.0 6.1e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.4 NM_003358.2_1 - 4.3e-09 36.4 5.9 4.3e-09 36.4 5.9 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.24 NM_003358.2_1 - 0.0051 16.5 0.0 0.0085 15.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Aldedh PF00171.20 NM_001145396.1_3 - 2.7e-105 352.4 0.0 2.6e-34 118.4 0.0 3.0 2 1 1 3 3 3 3 Aldehyde dehydrogenase family DUF1487 PF07368.9 NM_001145396.1_3 - 0.013 14.8 0.0 0.17 11.2 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1487) SDH_alpha PF03313.13 NM_001145396.1_3 - 0.054 13.0 0.7 0.6 9.6 0.1 2.1 2 0 0 2 2 2 0 Serine dehydratase alpha chain PTCRA PF15028.4 NM_138296.2_1 - 1e-69 232.0 1.6 2.2e-69 230.9 1.6 1.6 1 0 0 1 1 1 1 Pre-T-cell antigen receptor C1-set PF07654.13 NM_138296.2_1 - 0.076 13.4 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin C1-set domain Kinesin PF00225.21 NM_001300792.1_1 - 2.4e-120 401.3 0.1 3.7e-120 400.7 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 NM_001300792.1_1 - 4.8e-26 91.4 0.0 1.3e-25 90.0 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding AAA_22 PF13401.4 NM_001300792.1_1 - 0.21 11.7 3.3 5.2 7.2 0.0 2.6 2 1 0 2 2 2 0 AAA domain Kinesin_assoc PF16183.3 NM_001300792.1_1 - 4.7 7.2 15.0 12 5.8 15.0 1.7 1 1 0 1 1 1 0 Kinesin-associated Isy1 PF06246.10 NM_001204890.1_1 - 3.7e-98 328.0 10.6 4.7e-98 327.7 10.6 1.1 1 0 0 1 1 1 1 Isy1-like splicing family DUF4746 PF15928.3 NM_001204890.1_1 - 0.039 13.3 7.7 0.059 12.6 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CDC45 PF02724.12 NM_001204890.1_1 - 9.2 4.3 6.2 13 3.8 6.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Ras PF00071.20 NM_001204890.1_3 - 8.1e-36 122.9 0.0 1.1e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001204890.1_3 - 7.2e-17 61.6 0.0 1.1e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001204890.1_3 - 0.0002 20.7 0.0 0.00029 20.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTSE1_N PF15259.4 NM_016426.6_3 - 1.9e-62 209.6 0.8 3.3e-62 208.8 0.8 1.4 1 0 0 1 1 1 1 G-2 and S-phase expressed 1 cNMP_binding PF00027.27 NM_001321989.1_3 - 1.1e-41 140.6 0.1 2.7e-21 75.2 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 NM_001321989.1_3 - 7.6e-17 60.6 0.1 1.4e-16 59.7 0.1 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit zf-C2H2_assoc3 PF16637.3 NM_032050.1_2 - 1.7e-29 101.9 6.2 4.8e-29 100.5 6.2 1.9 1 0 0 1 1 1 1 Putative zinc-finger between two C2H2 zinc-fingers on Patz BTB PF00651.29 NM_032050.1_2 - 1.8e-25 89.2 0.0 2.8e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 NM_032050.1_2 - 9.2e-22 75.7 44.8 0.0018 18.8 0.3 8.4 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_032050.1_2 - 1.2e-14 53.7 67.8 0.00024 21.3 0.8 9.2 10 0 0 10 10 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_032050.1_2 - 2.2e-12 46.7 49.2 1.1e-05 25.5 2.3 8.8 9 0 0 9 9 9 4 Zinc-finger double domain zf-C2H2_jaz PF12171.6 NM_032050.1_2 - 1e-07 31.9 22.5 0.85 9.9 0.4 7.9 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_032050.1_2 - 2.1e-06 27.4 7.3 2e-05 24.3 2.0 7.9 8 0 0 8 8 8 2 C2H2-type zinc finger zf-met PF12874.5 NM_032050.1_2 - 6.6e-05 23.0 29.7 1.7 9.0 0.0 7.7 8 0 0 8 8 7 3 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 NM_032050.1_2 - 0.17 12.0 12.2 0.087 13.0 4.7 3.4 2 1 1 3 3 3 0 C2H2-type zinc ribbon ARS2 PF04959.11 NM_032050.1_2 - 0.25 11.5 6.8 0.39 10.9 0.1 3.4 3 1 1 4 4 4 0 Arsenite-resistance protein 2 GAGA PF09237.9 NM_032050.1_2 - 1.2 8.8 17.4 13 5.6 0.5 5.6 4 1 1 5 5 5 0 GAGA factor Zn_ribbon_2 PF12674.5 NM_032050.1_2 - 1.3 9.6 8.1 11 6.6 1.7 3.3 3 0 0 3 3 2 0 Putative zinc ribbon domain Zn-ribbon_8 PF09723.8 NM_032050.1_2 - 2.8 8.0 33.8 0.16 12.0 0.5 6.1 5 1 2 7 7 7 0 Zinc ribbon domain zf-C2H2_9 PF16293.3 NM_032050.1_2 - 3.5 7.4 8.1 4.4 7.1 0.0 4.0 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) M16C_assoc PF08367.9 NM_014889.3_1 - 2.9e-84 282.0 0.0 4.4e-84 281.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.19 NM_014889.3_1 - 7.2e-38 130.3 0.2 1.6e-26 93.3 0.0 3.3 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.18 NM_014889.3_1 - 1.2e-09 38.2 0.0 1e-05 25.4 0.0 3.3 2 1 0 2 2 2 2 Insulinase (Peptidase family M16) zf-C2H2 PF00096.24 NM_001146184.1_1 - 2.2e-45 150.5 72.2 0.00058 20.0 1.6 14.0 13 0 0 13 13 13 12 Zinc finger, C2H2 type SCAN PF02023.15 NM_001146184.1_1 - 2.5e-30 104.0 0.9 2.5e-30 104.0 0.9 1.8 2 0 0 2 2 2 1 SCAN domain zf-C2H2_4 PF13894.4 NM_001146184.1_1 - 1.2e-19 69.2 85.0 0.053 14.2 0.3 13.9 14 0 0 14 14 14 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001146184.1_1 - 1.6e-05 24.6 74.8 0.11 12.3 0.2 12.7 12 0 0 12 12 12 6 C2H2-type zinc finger zf-C2HC_2 PF13913.4 NM_001146184.1_1 - 0.00076 19.2 40.6 0.27 11.0 0.1 9.9 10 0 0 10 10 10 4 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 NM_001146184.1_1 - 5.1 7.4 49.0 4.9 7.4 0.6 10.6 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding TruD PF01142.16 NM_001318164.1_3 - 5.6e-73 246.0 0.0 6.9e-68 229.2 0.0 2.2 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) R3H PF01424.20 NM_001318164.1_3 - 0.068 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 R3H domain XPG_I_2 PF12813.5 NM_001318164.1_3 - 0.1 11.9 0.1 0.17 11.2 0.1 1.2 1 0 0 1 1 1 0 XPG domain containing 7tm_1 PF00001.19 NM_000730.2_1 - 1e-64 218.3 12.7 1.3e-64 217.9 12.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CholecysA-Rec_N PF09193.8 NM_000730.2_1 - 1.6e-26 91.9 0.2 1.6e-26 91.9 0.2 2.0 2 0 0 2 2 2 1 Cholecystokinin A receptor, N-terminal 7tm_4 PF13853.4 NM_000730.2_1 - 2.1e-09 37.4 7.8 2.1e-09 37.4 7.8 1.5 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 NM_000730.2_1 - 3.1e-09 36.4 20.2 1.4e-08 34.4 20.2 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_000730.2_1 - 0.00023 20.4 15.5 0.00023 20.4 15.5 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx zf-H2C2_2 PF13465.4 NM_001202412.1_1 - 2.9e-70 229.6 98.9 1.8e-09 37.5 1.2 14.7 15 0 0 15 15 14 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001202412.1_1 - 6e-57 186.9 103.9 1.8e-07 31.1 1.2 17.5 17 0 0 17 17 17 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001202412.1_1 - 3.1e-30 102.1 99.3 0.00069 20.1 1.1 15.8 15 0 0 15 15 15 9 C2H2-type zinc finger KRAB PF01352.25 NM_001202412.1_1 - 4.2e-25 87.0 2.5 9.1e-25 85.9 2.5 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001202412.1_1 - 2.9e-15 56.0 45.0 0.0044 17.2 0.6 11.1 11 0 0 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001202412.1_1 - 7.3e-11 41.6 80.1 0.0024 17.6 0.4 13.2 13 0 0 13 13 13 8 C2H2-type zinc finger XPA_N PF01286.16 NM_001202412.1_1 - 9.1e-08 31.9 70.2 0.44 10.5 0.0 14.0 14 0 0 14 14 14 7 XPA protein N-terminal Zn-ribbon_8 PF09723.8 NM_001202412.1_1 - 0.00027 20.9 70.7 0.12 12.4 4.5 9.6 3 2 7 11 11 11 9 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_001202412.1_1 - 0.037 14.7 59.0 0.21 12.2 2.3 7.4 2 2 4 7 7 7 0 zinc-ribbon family zf-BED PF02892.13 NM_001202412.1_1 - 0.11 12.4 0.1 0.11 12.4 0.1 11.9 7 4 7 14 14 14 0 BED zinc finger zf-C2H2_11 PF16622.3 NM_001202412.1_1 - 0.17 11.6 63.6 0.36 10.5 0.2 11.6 12 0 0 12 12 12 0 zinc-finger C2H2-type DUF89 PF01937.17 NM_001286562.1_3 - 1.4e-117 392.6 0.1 1.7e-117 392.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 AIG2_2 PF13772.4 NM_001199817.1_1 - 0.15 12.4 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 AIG2-like family Piwi PF02171.15 NM_177422.2_1 - 5.8e-112 373.7 0.0 8e-112 373.2 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 NM_177422.2_1 - 2.1e-32 111.1 0.1 4.6e-32 110.0 0.1 1.6 1 0 0 1 1 1 1 Mid domain of argonaute PAZ PF02170.20 NM_177422.2_1 - 5.5e-29 100.6 0.9 8.6e-29 100.0 0.9 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.3 NM_177422.2_1 - 3.5e-12 46.3 0.0 7e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoN PF16486.3 NM_177422.2_1 - 0.0003 21.4 0.0 0.0008 20.0 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoN PF16486.3 NM_177422.2_3 - 0.0087 16.6 0.0 0.014 16.0 0.0 1.2 1 0 0 1 1 1 1 N-terminal domain of argonaute GPR_Gpa2_C PF11970.6 NM_001193531.1_3 - 0.013 15.4 1.0 0.029 14.3 0.1 2.1 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term Fumarate_red_C PF02300.15 NM_001193531.1_3 - 1.3 8.9 8.2 1.1 9.2 1.8 2.6 3 0 0 3 3 3 0 Fumarate reductase subunit C Myb_DNA-binding PF00249.29 NM_001488.4_1 - 1.8e-11 43.8 0.1 4.7e-11 42.5 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.15 NM_001488.4_1 - 4.1e-08 33.3 0.0 1.7e-07 31.3 0.0 2.0 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-bind_6 PF13921.4 NM_001488.4_1 - 6.9e-06 26.1 0.3 3.7e-05 23.7 0.1 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Mpp10 PF04006.10 NM_001207030.1_3 - 1e-12 47.2 34.0 2.8e-12 45.8 34.0 1.6 1 1 0 1 1 1 1 Mpp10 protein Kazal_1 PF00050.19 NM_001271720.1_3 - 2.6e-18 65.6 3.9 4.1e-18 65.0 3.9 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 NM_001271720.1_3 - 2e-09 37.3 1.6 3.2e-09 36.7 1.6 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain DUF3713 PF12506.6 NM_133484.1_3 - 0.0025 18.0 0.7 0.0025 18.0 0.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3713) PspA_IM30 PF04012.10 NM_133484.1_3 - 0.0037 16.7 2.6 0.0055 16.2 2.6 1.1 1 0 0 1 1 1 1 PspA/IM30 family IncA PF04156.12 NM_133484.1_3 - 0.0084 15.8 3.3 0.01 15.5 3.3 1.2 1 0 0 1 1 1 1 IncA protein FliD_N PF02465.16 NM_133484.1_3 - 0.0093 16.5 1.6 0.018 15.6 1.6 1.5 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 N-terminus MRF_C1 PF13887.4 NM_133484.1_3 - 0.1 11.7 2.1 0.12 11.4 0.1 1.9 2 0 0 2 2 2 0 Myelin gene regulatory factor -C-terminal domain 1 Rota_NSP4 PF01452.14 NM_133484.1_3 - 0.12 11.9 2.0 0.32 10.5 1.7 1.7 1 1 1 2 2 2 0 Rotavirus non structural protein HAGH_C PF16123.3 NM_001290137.1_3 - 1e-20 73.9 0.0 1.6e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 NM_001290137.1_3 - 5.8e-11 42.6 1.5 7e-10 39.1 1.5 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 NM_001290137.1_3 - 0.0005 19.5 0.2 0.0012 18.3 0.1 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain zf-Tim10_DDP PF02953.13 NM_001304485.1_2 - 2.8e-15 55.6 3.9 5.5e-15 54.6 3.9 1.5 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2116 PF09889.7 NM_001304485.1_2 - 0.11 12.4 0.3 0.22 11.4 0.3 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) PX PF00787.22 NM_152897.2_3 - 1.3e-05 25.0 0.0 2.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 PX domain tRNA-synt_2b PF00587.23 NM_001145901.1_2 - 2.7e-25 89.2 0.0 5.2e-25 88.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF2312 PF10073.7 NM_001145901.1_2 - 0.036 13.6 0.3 0.062 12.8 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) Seryl_tRNA_N PF02403.20 NM_001145901.1_2 - 0.083 13.0 0.2 0.18 11.9 0.2 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain C9orf72-like PF15019.4 NM_001256054.2_2 - 1.6e-95 319.1 0.0 2.2e-95 318.7 0.0 1.2 1 0 0 1 1 1 1 C9orf72-like protein family GBP PF02263.17 NM_001127713.1_3 - 4e-102 340.8 0.1 5.2e-102 340.4 0.1 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 NM_001127713.1_3 - 4.7e-05 22.8 0.1 7e-05 22.2 0.1 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain F5_F8_type_C PF00754.23 NM_001114614.2_1 - 1.8e-38 131.4 5.3 7.3e-26 90.6 0.0 3.1 2 1 1 3 3 3 3 F5/8 type C domain EGF PF00008.25 NM_001114614.2_1 - 2.1e-07 31.0 6.3 2.1e-07 31.0 6.3 2.5 3 0 0 3 3 3 1 EGF-like domain cEGF PF12662.5 NM_001114614.2_1 - 0.062 13.1 5.0 0.18 11.6 5.0 1.8 1 0 0 1 1 1 0 Complement Clr-like EGF-like EGF_3 PF12947.5 NM_001114614.2_1 - 0.38 10.9 7.2 1 9.5 7.2 1.8 1 0 0 1 1 1 0 EGF domain EGF_2 PF07974.11 NM_001114614.2_1 - 4.1 7.7 11.0 0.11 12.7 3.5 2.4 2 1 0 2 2 2 0 EGF-like domain zf-CCCH PF00642.22 NM_175854.7_3 - 0.00044 19.9 3.1 0.001 18.8 3.1 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pkinase PF00069.23 NM_175854.7_3 - 0.0052 16.0 0.0 0.012 14.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Torus PF16131.3 NM_175854.7_3 - 0.22 12.1 2.9 0.27 11.8 0.4 2.1 2 0 0 2 2 2 0 Torus domain Dynamin_N PF00350.21 NM_001010906.1_3 - 1.2e-16 61.1 0.0 4.7e-16 59.2 0.0 2.2 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.21 NM_001010906.1_3 - 8.7e-06 25.7 1.0 0.00013 21.9 0.1 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.4 NM_001010906.1_3 - 0.0011 19.3 2.7 0.066 13.4 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain ABC_tran PF00005.25 NM_001010906.1_3 - 0.0013 19.1 0.1 0.0053 17.2 0.0 2.0 2 0 0 2 2 2 1 ABC transporter DUF258 PF03193.14 NM_001010906.1_3 - 0.0021 17.9 0.2 0.01 15.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AIG1 PF04548.14 NM_001010906.1_3 - 0.0048 16.1 0.1 0.027 13.6 0.1 2.2 2 0 0 2 2 2 1 AIG1 family Zeta_toxin PF06414.10 NM_001010906.1_3 - 0.051 12.7 0.2 0.22 10.6 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.4 NM_001010906.1_3 - 0.053 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF87 PF01935.15 NM_001010906.1_3 - 0.12 12.2 0.1 0.12 12.2 0.1 3.8 5 0 0 5 5 5 0 Domain of unknown function DUF87 KAP_NTPase PF07693.12 NM_001010906.1_3 - 0.84 8.7 7.7 0.25 10.4 0.5 3.1 3 1 0 3 3 3 0 KAP family P-loop domain EMI PF07546.11 NM_001010906.1_3 - 1.1 9.9 5.9 9.1 7.0 0.3 3.5 3 0 0 3 3 3 0 EMI domain DAG1 PF05454.9 NM_004393.5_2 - 5.5e-162 537.8 7.3 8e-162 537.3 7.3 1.2 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) TMEM154 PF15102.4 NM_004393.5_2 - 0.0079 16.0 0.0 0.0079 16.0 0.0 1.8 2 0 0 2 2 2 1 TMEM154 protein family PI-PLC-X PF00388.17 NM_133373.4_1 - 1e-61 206.7 0.0 1.9e-61 205.8 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 NM_133373.4_1 - 8.3e-40 135.6 0.0 1.4e-39 134.9 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_10 PF14788.4 NM_133373.4_1 - 2.5e-25 87.9 2.2 5.1e-25 87.0 2.2 1.5 1 0 0 1 1 1 1 EF hand EF-hand_like PF09279.9 NM_133373.4_1 - 1.2e-23 83.2 1.0 2.5e-23 82.3 0.2 1.9 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.28 NM_133373.4_1 - 1.5e-15 57.2 0.0 2.7e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain EF-hand_6 PF13405.4 NM_133373.4_1 - 0.00088 18.9 0.4 3.1 7.9 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 NM_133373.4_1 - 0.0019 18.5 0.9 0.029 14.7 0.3 2.6 1 1 2 3 3 3 2 EF-hand domain pair S_100 PF01023.17 NM_133373.4_1 - 0.005 16.4 0.6 0.015 14.9 0.0 2.1 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain PH PF00169.27 NM_133373.4_1 - 0.008 16.5 0.0 0.017 15.5 0.0 1.4 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.30 NM_133373.4_1 - 0.071 12.6 0.1 2 8.0 0.0 2.6 2 0 0 2 2 2 0 EF hand SPARC_Ca_bdg PF10591.7 NM_133373.4_1 - 0.092 12.9 0.2 0.23 11.7 0.2 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Sprouty PF05210.11 NM_181784.2_2 - 3.1e-25 88.6 25.9 7.4e-25 87.4 25.9 1.7 1 0 0 1 1 1 1 Sprouty protein (Spry) WH1 PF00568.21 NM_181784.2_2 - 1.2e-09 37.9 0.0 2.5e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 WH1 domain Metallophos PF00149.26 NM_001319154.1_2 - 4.6e-10 40.2 0.2 8.3e-10 39.4 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 NM_001319154.1_2 - 2.1e-06 27.9 0.0 3.2e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain NDUFA12 PF05071.14 NM_018838.4_1 - 4.4e-30 104.2 5.7 5.7e-30 103.9 5.7 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Folliculin_C PF16692.3 NM_144997.5_1 - 2.6e-91 305.2 0.1 4.3e-91 304.5 0.1 1.3 1 0 0 1 1 1 1 Folliculin C-terminal domain Folliculin PF11704.6 NM_144997.5_1 - 2.7e-51 173.8 0.0 4.6e-51 173.1 0.0 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Glyco_transf_7N PF13733.4 NM_003779.3_2 - 1.6e-56 189.5 0.0 2.2e-56 189.1 0.0 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 NM_003779.3_2 - 5.8e-30 102.7 0.1 1.4e-29 101.4 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase 7tm_1 PF00001.19 NM_001277206.1_3 - 5.4e-41 140.5 8.0 8.8e-41 139.8 8.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 NM_001277206.1_3 - 0.0071 15.6 0.1 0.012 14.8 0.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv BIR PF00653.19 NM_001166.4_1 - 7.1e-64 212.3 6.5 4.4e-21 75.2 1.2 3.6 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain CARD PF00619.19 NM_001166.4_1 - 2.8e-23 81.6 1.0 6.4e-23 80.5 1.0 1.6 1 0 0 1 1 1 1 Caspase recruitment domain zf-C3HC4_3 PF13920.4 NM_001166.4_1 - 6.1e-14 51.5 8.4 6.1e-14 51.5 8.4 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_001166.4_1 - 4.1e-07 29.6 8.1 1e-06 28.3 8.1 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF2039 PF10217.7 NM_001166.4_1 - 0.23 11.7 4.3 0.6 10.4 4.3 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) WD40 PF00400.30 NM_145241.4_3 - 1.7e-21 75.9 4.9 1.6e-05 25.4 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_145241.4_3 - 5.3e-05 23.3 0.2 0.051 13.8 0.1 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_145241.4_3 - 0.0045 15.5 1.7 0.77 8.2 0.3 3.2 2 1 2 4 4 4 2 Nucleoporin Nup120/160 CFC PF09443.8 NM_001270420.1_3 - 8.5e-15 54.2 9.5 8.5e-15 54.2 9.5 1.9 2 0 0 2 2 2 1 Cripto_Frl-1_Cryptic (CFC) CP2 PF04516.13 NM_001173452.1_2 - 8.2e-57 192.0 0.0 1.4e-56 191.3 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor DUF2967 PF11179.6 NM_001173452.1_2 - 1.2 8.4 3.6 1.9 7.8 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) DJ-1_PfpI PF01965.22 NM_007262.4_2 - 1.2e-51 174.7 0.1 1.5e-51 174.3 0.1 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.3 NM_007262.4_2 - 0.002 17.7 0.0 0.097 12.2 0.0 2.2 1 1 1 2 2 2 2 ThiJ/PfpI family-like GATase_3 PF07685.12 NM_007262.4_2 - 0.0065 16.0 0.1 0.014 14.9 0.1 1.5 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DUF1241 PF06840.9 NM_145860.1_1 - 9.3e-63 210.2 3.4 1.3e-62 209.7 3.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Focal_AT PF03623.11 NM_145860.1_1 - 0.042 13.6 0.1 0.087 12.6 0.1 1.5 1 0 0 1 1 1 0 Focal adhesion targeting region CENP-L PF13092.4 NM_145860.1_1 - 0.046 13.8 0.2 0.068 13.2 0.2 1.2 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Med11 PF10280.7 NM_145860.1_1 - 0.096 13.0 0.6 0.2 12.0 0.4 1.6 1 1 0 1 1 1 0 Mediator complex protein Syntaxin_2 PF14523.4 NM_145860.1_1 - 0.32 11.3 5.0 0.77 10.0 5.0 1.7 1 1 0 1 1 1 0 Syntaxin-like protein zf-H2C2_2 PF13465.4 NM_001112734.3_2 - 1.9e-51 170.2 46.9 5.1e-09 36.1 1.9 9.8 9 0 0 9 9 9 6 Zinc-finger double domain SCAN PF02023.15 NM_001112734.3_2 - 1e-40 137.3 6.7 1.7e-40 136.6 6.7 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 NM_001112734.3_2 - 1.2e-33 113.6 55.5 2e-06 27.8 0.4 8.3 9 0 0 9 9 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001112734.3_2 - 4.3e-20 70.5 40.1 0.015 15.9 0.4 8.0 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001112734.3_2 - 1.4e-10 41.1 18.8 0.32 11.2 0.3 7.2 7 0 0 7 7 6 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001112734.3_2 - 1.5e-07 31.1 40.1 0.0087 15.9 0.3 7.7 8 0 0 8 8 8 5 C2H2-type zinc finger XPA_N PF01286.16 NM_001112734.3_2 - 0.0041 17.0 30.4 5 7.1 1.1 7.5 7 0 0 7 7 7 2 XPA protein N-terminal Zn-ribbon_8 PF09723.8 NM_001112734.3_2 - 0.079 13.0 41.0 0.32 11.0 5.1 5.5 2 1 5 7 7 7 0 Zinc ribbon domain C1_4 PF07975.10 NM_001112734.3_2 - 0.14 12.3 29.2 0.057 13.6 3.2 5.3 3 2 3 6 6 6 0 TFIIH C1-like domain zf-C2H2_11 PF16622.3 NM_001112734.3_2 - 0.14 11.8 28.5 1.9 8.2 0.9 6.7 6 0 0 6 6 6 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_001112734.3_2 - 1.7 9.3 27.4 0.78 10.4 2.5 4.7 2 1 4 6 6 6 0 zinc-ribbon family zf-LYAR PF08790.9 NM_001112734.3_2 - 5.3 6.9 22.8 28 4.6 0.1 7.1 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger Myelin_PLP PF01275.17 NM_001305004.1_3 - 4.5e-70 236.0 4.9 6.6e-70 235.5 4.9 1.2 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) NUDIX PF00293.26 NM_001244390.1_3 - 3.5e-21 75.5 0.6 4.8e-21 75.0 0.6 1.1 1 0 0 1 1 1 1 NUDIX domain Homeobox PF00046.27 NM_006982.2_2 - 7.7e-24 83.1 6.1 1.7e-23 82.0 6.1 1.6 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 NM_006982.2_2 - 9.5e-10 37.9 2.1 2.4e-09 36.6 2.1 1.7 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 NM_006982.2_2 - 0.0017 18.1 0.2 0.0049 16.6 0.2 1.8 1 0 0 1 1 1 1 Homeobox KN domain zf-C4 PF00105.16 NM_001206992.1_2 - 1.4e-28 99.0 14.3 1.4e-28 99.0 14.3 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001206992.1_2 - 6.4e-26 91.1 1.5 6.4e-26 91.1 1.5 2.1 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor wnt PF00110.17 NM_003392.4_1 - 1.4e-119 399.0 24.5 1.8e-119 398.7 24.5 1.1 1 0 0 1 1 1 1 wnt family Mucin2_WxxW PF13330.4 NM_003613.3_2 - 3.6e-20 72.4 0.0 3.6e-20 72.4 0.0 3.5 4 0 0 4 4 4 1 Mucin-2 protein WxxW repeating region Ig_3 PF13927.4 NM_003613.3_2 - 6.5e-12 45.8 0.0 1.5e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_003613.3_2 - 1.4e-08 34.8 0.0 3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain CarbopepD_reg_2 PF13715.4 NM_003613.3_2 - 4.2e-08 32.9 0.0 0.013 15.4 0.0 2.5 2 0 0 2 2 2 2 CarboxypepD_reg-like domain CarboxypepD_reg PF13620.4 NM_003613.3_2 - 7.1e-08 32.5 0.0 1.2e-05 25.3 0.0 2.6 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain TSP_1 PF00090.17 NM_003613.3_2 - 8.4e-08 32.2 11.0 8.4e-08 32.2 11.0 3.3 3 0 0 3 3 3 1 Thrombospondin type 1 domain I-set PF07679.14 NM_003613.3_2 - 3.5e-07 30.1 0.0 7.6e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_003613.3_2 - 8.8e-05 22.5 0.0 0.00025 21.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 NM_003613.3_2 - 0.075 13.1 0.1 6.4 6.8 0.0 2.7 1 1 1 2 2 2 0 Immunoglobulin V-set domain Pkinase PF00069.23 NM_003684.5_2 - 4.5e-61 206.4 0.1 1.6e-36 125.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_003684.5_2 - 1.2e-23 83.5 0.1 9.7e-12 44.6 0.2 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase zf-RRN7 PF11781.6 NM_003684.5_2 - 0.0015 18.0 0.2 0.0037 16.8 0.2 1.7 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 APH PF01636.21 NM_003684.5_2 - 0.0029 17.4 0.3 0.15 11.8 0.0 2.6 2 1 0 2 2 2 1 Phosphotransferase enzyme family fn3 PF00041.19 NM_001135095.1_1 - 1.2e-93 307.5 0.0 2.9e-11 43.4 0.0 9.9 10 1 0 10 10 10 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_001135095.1_1 - 1e-22 80.4 2.3 0.11 12.9 0.1 8.9 8 1 0 8 8 8 7 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 NM_001135095.1_1 - 9e-09 35.6 0.0 8.7 6.8 0.0 6.6 6 0 0 6 6 6 4 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 NM_001135095.1_1 - 4.1e-07 30.1 6.8 4.8 7.4 0.0 7.5 7 1 1 8 8 8 2 Interferon-alpha/beta receptor, fibronectin type III Glyco_transf_29 PF00777.16 NM_013443.4_2 - 3.9e-33 114.8 0.0 5.6e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Actin PF00022.17 NM_005721.4_2 - 2.2e-88 296.5 0.0 8.3e-86 288.0 0.0 2.1 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.11 NM_005721.4_2 - 0.0063 15.2 0.0 1.4 7.5 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein fn3 PF00041.19 NM_001242636.1_1 - 1.2e-22 79.9 14.1 3.1e-08 33.7 0.0 5.2 5 0 0 5 5 5 4 Fibronectin type III domain IL6Ra-bind PF09240.8 NM_001242636.1_1 - 8.4e-08 32.4 3.6 1.4e-07 31.7 0.7 2.7 3 0 0 3 3 3 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.8 NM_001242636.1_1 - 2.3e-06 27.6 0.5 8.1e-06 25.9 0.4 1.9 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding IL4Ra_N PF09238.8 NM_001242636.1_1 - 0.0051 17.0 0.6 0.018 15.2 0.6 1.9 1 0 0 1 1 1 1 Interleukin-4 receptor alpha chain, N-terminal Interfer-bind PF09294.8 NM_001242636.1_1 - 0.022 14.9 3.1 2.2 8.5 0.0 3.3 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.3 NM_001242636.1_1 - 0.055 13.9 10.0 0.055 13.9 0.0 3.6 3 1 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain P16-Arc PF04699.12 NM_001270439.1_1 - 4.4e-57 192.6 0.0 6.3e-57 192.1 0.0 1.2 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.10 NM_001270439.1_1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Dip2/Utp12 Family Pkinase PF00069.23 NM_001271978.1_2 - 8.1e-70 235.1 0.0 1e-69 234.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001271978.1_2 - 3.5e-51 173.9 0.0 5.4e-51 173.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1241 PF06840.9 NM_001271978.1_2 - 0.00042 19.9 0.0 0.00078 19.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Kinase-like PF14531.4 NM_001271978.1_2 - 0.019 14.1 0.0 0.052 12.7 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Acyltransferase PF01553.19 NM_001303465.1_3 - 2e-29 101.8 0.0 9.8e-29 99.5 0.0 1.9 1 1 0 1 1 1 1 Acyltransferase zf-H2C2_2 PF13465.4 NM_001321320.1_1 - 7.2e-122 392.7 126.3 3.4e-08 33.4 0.2 20.1 20 0 0 20 20 20 19 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001321320.1_1 - 1.3e-84 274.0 144.1 5.4e-07 29.6 0.9 19.6 19 0 0 19 19 19 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001321320.1_1 - 8e-52 169.3 136.5 0.0011 19.5 0.6 20.2 20 0 0 20 20 19 19 C2H2-type zinc finger KRAB PF01352.25 NM_001321320.1_1 - 1.4e-23 82.1 0.7 2.6e-23 81.3 0.7 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001321320.1_1 - 2.7e-20 71.7 109.8 0.0084 15.9 2.0 20.0 19 0 0 19 19 19 14 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001321320.1_1 - 8.3e-14 51.3 80.5 0.026 14.5 1.2 11.9 4 3 9 14 14 14 12 Zinc ribbon domain DUF3268 PF11672.6 NM_001321320.1_1 - 4e-07 30.2 57.7 0.32 11.2 1.3 9.8 6 2 2 10 10 10 7 zinc-finger-containing domain zinc_ribbon_9 PF14369.4 NM_001321320.1_1 - 1.8e-06 28.0 52.8 2.5 8.3 0.2 15.7 17 1 1 18 18 18 3 zinc-ribbon zinc_ribbon_15 PF17032.3 NM_001321320.1_1 - 0.023 15.3 79.5 8.9 7.0 1.4 10.8 2 1 7 10 10 10 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_001321320.1_1 - 0.055 13.7 91.2 0.17 12.1 4.0 17.1 19 0 0 19 19 19 0 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001321320.1_1 - 0.1 12.6 72.6 15 5.6 0.1 18.1 19 0 0 19 19 19 0 XPA protein N-terminal CpXC PF14353.4 NM_001321320.1_1 - 5 7.1 71.5 5.3 7.0 0.6 15.0 10 6 4 15 15 15 0 CpXC protein Reprolysin PF01421.17 NM_001278114.1_3 - 4.6e-73 245.2 1.2 4.6e-73 245.2 1.2 2.3 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 NM_001278114.1_3 - 1.1e-22 80.7 0.1 3e-22 79.2 0.0 1.8 1 1 1 2 2 2 1 Reprolysin family propeptide Disintegrin PF00200.21 NM_001278114.1_3 - 4.1e-19 69.0 27.4 4.1e-19 69.0 27.4 4.2 3 1 0 3 3 3 1 Disintegrin ADAM_CR PF08516.10 NM_001278114.1_3 - 3.2e-11 43.6 9.6 3.2e-11 43.6 9.6 3.0 2 1 1 3 3 3 1 ADAM cysteine-rich Reprolysin_5 PF13688.4 NM_001278114.1_3 - 5.9e-05 23.2 0.9 0.00016 21.7 0.1 2.2 2 1 0 2 2 2 1 Metallo-peptidase family M12 HLH PF00010.24 NM_001024598.3_3 - 8e-13 48.0 6.4 1.2e-12 47.4 6.4 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Pou PF00157.15 NM_001024598.3_3 - 0.089 12.7 0.4 0.13 12.2 0.4 1.2 1 0 0 1 1 1 0 Pou domain - N-terminal to homeobox domain LELP1 PF15042.4 NM_001024598.3_3 - 2.3 8.6 9.7 0.061 13.7 1.4 2.2 1 1 1 2 2 2 0 Late cornified envelope-like proline-rich protein 1 RNA_pol_Rbc25 PF08292.10 NM_001018050.3_2 - 2.1e-41 141.0 0.0 3.5e-41 140.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.15 NM_001018050.3_2 - 1.9e-19 69.7 0.0 4.4e-19 68.5 0.0 1.7 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Rad51 PF08423.9 NM_001321810.1_3 - 8e-51 172.6 0.0 1.3e-50 172.0 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 NM_001321810.1_3 - 8.5e-10 38.4 0.0 1.3e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.13 NM_001321810.1_3 - 2.4e-07 30.2 0.4 1.3e-06 27.8 0.4 1.9 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.11 NM_001321810.1_3 - 3.3e-07 29.8 0.2 7.4e-07 28.6 0.2 1.6 1 1 0 1 1 1 1 KaiC RecA PF00154.19 NM_001321810.1_3 - 1.1e-05 24.9 0.8 0.00014 21.3 0.8 2.0 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_24 PF13479.4 NM_001321810.1_3 - 0.003 17.2 0.0 0.0058 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.16 NM_001321810.1_3 - 0.067 13.0 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA PF00004.27 NM_001321810.1_3 - 0.17 12.2 0.1 0.4 11.0 0.1 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FA_hydroxylase PF04116.11 NM_006745.4_2 - 1.9e-27 96.1 14.5 1.9e-27 96.1 14.5 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF4886 PF16227.3 NM_006745.4_2 - 0.086 11.8 0.4 0.14 11.2 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) TRAM_LAG1_CLN8 PF03798.14 NM_021267.4_1 - 2.9e-36 125.0 21.6 3.6e-36 124.6 21.6 1.1 1 0 0 1 1 1 1 TLC domain TGF_beta PF00019.18 NM_021267.4_3 - 5.7e-29 101.0 0.0 1e-28 100.2 0.0 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TPT PF03151.14 NM_001318370.1_1 - 8e-08 31.8 0.0 1.1e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 NM_001318370.1_1 - 3.1e-06 27.3 3.7 4.9e-06 26.6 3.7 1.3 1 0 0 1 1 1 1 EamA-like transporter family ILEI PF15711.3 NM_001282311.1_2 - 2.9e-25 88.4 0.0 4.3e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Interleukin-like EMT inducer PX PF00787.22 NM_007184.3_3 - 2.6e-19 69.1 0.1 6.2e-19 67.9 0.1 1.6 1 0 0 1 1 1 1 PX domain LRR_4 PF12799.5 NM_007184.3_3 - 8.3e-15 54.5 20.0 2.3e-05 24.5 1.5 4.2 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_007184.3_3 - 3.3e-12 45.8 17.4 9.1e-06 25.2 0.0 3.7 2 1 0 3 3 3 3 Leucine rich repeat LRR_9 PF14580.4 NM_007184.3_3 - 5.2e-08 32.4 2.7 7e-06 25.5 0.3 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.4 NM_007184.3_3 - 0.036 14.0 13.1 4.9 7.3 0.1 5.7 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.31 NM_007184.3_3 - 0.1 13.0 16.7 19 6.1 0.4 7.2 5 1 0 5 5 5 0 Leucine Rich Repeat BSP_II PF05432.9 NM_007184.3_3 - 2.4 7.6 18.0 4.6 6.7 18.0 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) SKG6 PF08693.8 NM_007184.3_3 - 5.2 6.4 9.9 10 5.5 9.9 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Serpin PF00079.18 NM_175041.1_3 - 2.3e-122 408.8 15.9 9.4e-64 215.9 12.6 2.1 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) Tup_N PF08581.8 NM_175041.1_3 - 4 7.7 7.5 28 5.0 0.1 3.3 3 0 0 3 3 3 0 Tup N-terminal DUF4675 PF15720.3 NM_001037671.3_2 - 6.5e-97 322.9 8.2 8.4e-97 322.5 8.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4675) Syntaphilin PF15290.4 NM_001318234.1_2 - 1.9e-141 471.1 1.0 2.6e-141 470.7 1.0 1.1 1 0 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp CALCOCO1 PF07888.9 NM_001318234.1_2 - 0.00049 18.7 6.0 0.00085 17.9 6.0 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Fez1 PF06818.13 NM_001318234.1_2 - 0.0063 16.8 6.7 0.011 16.1 6.7 1.2 1 0 0 1 1 1 1 Fez1 IncA PF04156.12 NM_001318234.1_2 - 0.015 14.9 3.0 0.026 14.2 3.0 1.2 1 0 0 1 1 1 0 IncA protein Exonuc_VII_L PF02601.13 NM_001318234.1_2 - 0.042 13.3 2.1 0.064 12.7 2.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit BST2 PF16716.3 NM_001318234.1_2 - 0.36 11.3 8.0 0.73 10.3 8.0 1.4 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 Spc7 PF08317.9 NM_001318234.1_2 - 0.69 8.6 8.7 1.1 8.0 8.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein PKcGMP_CC PF16808.3 NM_001318234.1_2 - 0.8 9.5 9.9 0.11 12.2 3.0 2.5 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Sec8_exocyst PF04048.12 NM_001318234.1_2 - 0.93 9.3 5.5 14 5.5 0.1 2.2 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain ArAE_1_C PF11728.6 NM_001318234.1_2 - 1 9.2 5.8 1.7 8.5 5.8 1.2 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain DUF641 PF04859.10 NM_001318234.1_2 - 1.1 9.4 3.9 0.4 10.9 0.3 1.8 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF16 PF01519.14 NM_001318234.1_2 - 2.2 8.7 7.5 8.3 6.8 7.5 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 Sec2p PF06428.9 NM_001318234.1_2 - 3.4 7.6 11.3 0.33 10.8 1.7 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p HR1 PF02185.14 NM_001318234.1_2 - 4.9 7.2 6.7 7.6 6.6 1.1 2.4 1 1 1 2 2 2 0 Hr1 repeat DEAD PF00270.27 NM_001322344.1_3 - 9.5e-13 48.2 0.0 1.7e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD-helicase PF00580.19 NM_001322344.1_3 - 0.19 11.1 0.0 0.19 11.1 0.0 2.5 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain Ras PF00071.20 NM_001204888.1_1 - 3.5e-10 39.6 0.1 4.9e-10 39.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001204888.1_1 - 2.4e-09 37.3 0.1 3.6e-09 36.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_001204888.1_2 - 4.6e-36 123.7 0.0 6.3e-36 123.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001204888.1_2 - 4e-17 62.4 0.0 5.9e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001204888.1_2 - 0.00013 21.4 0.1 0.00019 20.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Actin PF00022.17 NM_001024675.1_2 - 2e-75 253.8 0.0 6e-74 248.9 0.0 2.0 1 1 0 1 1 1 1 Actin Ribosomal_L22 PF00237.17 NM_014180.3_3 - 1e-27 96.4 0.1 1.7e-27 95.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF3534 PF12053.6 NM_152526.5_1 - 1.9e-61 206.5 0.0 5.2e-61 205.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3534) PDZ PF00595.22 NM_152526.5_1 - 7.3e-25 87.0 1.3 1.1e-16 60.8 0.2 3.6 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_152526.5_1 - 6.5e-08 32.6 0.1 6.5e-07 29.5 0.1 2.5 3 0 0 3 3 3 1 PDZ domain MMR_HSR1 PF01926.21 NM_006820.3_3 - 0.00073 19.5 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_PrkA PF08298.9 NM_006820.3_3 - 0.053 12.3 0.1 0.3 9.8 0.0 1.9 2 0 0 2 2 2 0 PrkA AAA domain AIG1 PF04548.14 NM_006820.3_3 - 0.056 12.6 1.0 0.61 9.2 0.1 2.1 2 0 0 2 2 2 0 AIG1 family AAA_29 PF13555.4 NM_006820.3_3 - 0.085 12.5 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.15 NM_006820.3_3 - 0.14 11.8 3.1 1.7 8.2 0.2 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein polyprenyl_synt PF00348.15 NM_001242825.1_3 - 1.6e-94 315.6 0.0 2e-94 315.3 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase zf-DHHC PF01529.18 NM_016598.2_2 - 1.8e-35 121.8 10.7 5.1e-35 120.4 10.7 1.8 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF898 PF05987.11 NM_016598.2_2 - 0.081 11.8 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Pkinase PF00069.23 NM_005921.1_1 - 6.5e-66 222.3 0.0 9.3e-66 221.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_005921.1_1 - 3.3e-39 134.6 0.0 6.1e-39 133.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_005921.1_1 - 1.3e-07 31.1 0.0 0.00018 20.8 0.0 2.3 2 0 0 2 2 2 2 Kinase-like zf-RING_2 PF13639.4 NM_005921.1_1 - 3.3e-05 23.9 11.9 3.3e-05 23.9 11.9 2.4 2 0 0 2 2 2 1 Ring finger domain PHD PF00628.27 NM_005921.1_1 - 0.029 14.1 8.8 0.093 12.5 8.8 2.0 1 0 0 1 1 1 0 PHD-finger APH PF01636.21 NM_005921.1_1 - 0.045 13.5 0.0 0.095 12.5 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Phostensin_N PF13916.4 NM_005921.1_1 - 0.068 13.4 0.2 0.19 11.9 0.2 1.8 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal FANCL_C PF11793.6 NM_005921.1_1 - 0.2 11.7 7.7 0.63 10.1 7.7 1.9 1 0 0 1 1 1 0 FANCL C-terminal domain zf-ANAPC11 PF12861.5 NM_005921.1_1 - 0.28 11.1 4.3 0.69 9.9 4.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 NM_005921.1_1 - 0.44 10.7 7.4 1.7 8.9 7.4 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain Troponin PF00992.18 NM_001042782.2_3 - 1.1e-32 113.0 34.2 1.1e-32 113.0 34.2 3.1 2 1 1 3 3 3 2 Troponin DUF4250 PF14056.4 NM_001042782.2_3 - 0.065 13.1 0.2 0.16 11.8 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) Alpha-amylase_C PF02806.16 NM_000158.3_2 - 1.2e-25 89.6 0.0 2.7e-25 88.5 0.0 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.16 NM_000158.3_2 - 1e-17 64.1 0.1 1.9e-17 63.2 0.1 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.22 NM_000158.3_2 - 2.3e-13 50.3 0.8 7.1e-12 45.4 0.0 2.5 1 1 2 3 3 3 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.4 NM_000158.3_2 - 0.021 13.8 0.0 0.092 11.7 0.0 2.0 2 0 0 2 2 2 0 Glycogen debranching enzyme, glucanotransferase domain KASH PF10541.7 NM_182913.2_3 - 3.4e-29 100.8 5.5 6.6e-29 99.8 5.5 1.5 1 0 0 1 1 1 1 Nuclear envelope localisation domain Spectrin PF00435.19 NM_182913.2_3 - 5.1e-13 49.3 15.0 1.6e-08 34.8 2.6 2.3 2 0 0 2 2 2 2 Spectrin repeat Allexi_40kDa PF05549.9 NM_182913.2_3 - 0.003 17.0 4.2 0.043 13.2 0.1 2.1 2 0 0 2 2 2 2 Allexivirus 40kDa protein Syntaxin_2 PF14523.4 NM_182913.2_3 - 0.42 10.9 4.5 4.6 7.5 0.1 2.5 2 1 0 2 2 2 0 Syntaxin-like protein PCRF PF03462.16 NM_182913.2_3 - 6.7 6.4 9.5 2.7 7.6 1.1 2.4 2 0 0 2 2 2 0 PCRF domain MH2 PF03166.12 NM_001003688.1_1 - 7.7e-76 254.3 1.5 1.1e-75 253.9 1.5 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 NM_001003688.1_1 - 7e-42 141.7 1.2 1.5e-41 140.6 1.2 1.6 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 NM_001003688.1_1 - 0.00042 20.0 0.0 0.0007 19.3 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 Sugar_tr PF00083.22 NM_001286233.1_1 - 4.7e-153 510.1 22.2 6.1e-153 509.8 22.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 NM_001286233.1_1 - 1.2e-14 54.0 34.4 2.4e-14 52.9 21.3 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.10 NM_001286233.1_1 - 1.1 9.5 5.3 3.2 8.1 5.3 1.7 1 0 0 1 1 1 0 Phage holin family 2 Ank_2 PF12796.5 NM_019841.6_1 - 2.1e-24 85.8 3.4 9.2e-11 42.1 0.5 3.3 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ion_trans PF00520.29 NM_019841.6_1 - 1.8e-18 66.6 20.5 2.7e-18 65.9 20.5 1.3 1 0 0 1 1 1 1 Ion transport protein Ank_3 PF13606.4 NM_019841.6_1 - 2.8e-15 54.7 4.8 0.0042 17.3 0.0 6.4 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.28 NM_019841.6_1 - 5.9e-14 51.7 2.8 0.0012 19.1 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.4 NM_019841.6_1 - 6.1e-13 48.9 2.2 0.00016 22.0 0.0 4.4 3 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_019841.6_1 - 8.4e-13 48.2 5.1 0.00048 20.3 0.0 4.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) GCSF PF16647.3 NM_172219.2_1 - 1.5e-93 310.4 2.7 2e-93 309.9 2.7 1.2 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor PseudoU_synth_2 PF00849.20 NM_001324410.1_1 - 1.1e-22 80.7 0.0 1.6e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase COG6 PF06419.9 NM_020751.2_2 - 3.4e-209 696.0 9.0 4e-209 695.7 9.0 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 ApoLp-III PF07464.9 NM_020751.2_2 - 0.0059 16.6 2.9 0.0059 16.6 2.9 1.9 2 0 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) DUF972 PF06156.11 NM_020751.2_2 - 0.093 13.2 0.9 0.37 11.3 0.9 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF972) zf-H2C2_2 PF13465.4 NM_001322915.1_2 - 1.2e-96 313.0 97.9 1.9e-08 34.3 1.4 15.9 15 0 0 15 15 15 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001322915.1_2 - 5.9e-81 262.5 126.2 8.3e-07 29.0 1.0 16.2 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001322915.1_2 - 2.9e-44 145.7 114.5 0.00037 20.9 1.8 16.0 16 0 0 16 16 15 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001322915.1_2 - 1.4e-25 88.5 95.8 0.00091 19.0 0.4 14.6 14 0 0 14 14 14 12 C2H2-type zinc finger KRAB PF01352.25 NM_001322915.1_2 - 2.7e-23 81.2 0.4 6.1e-23 80.1 0.4 1.7 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001322915.1_2 - 3.7e-16 58.8 66.2 0.00024 21.0 1.5 9.2 3 2 6 10 10 10 9 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_001322915.1_2 - 4.1e-06 27.3 63.0 0.61 10.7 1.7 8.0 1 1 5 7 7 7 6 zinc-ribbon family DUF3268 PF11672.6 NM_001322915.1_2 - 1.6e-05 25.1 51.7 0.38 11.0 1.3 7.7 1 1 4 8 8 8 6 zinc-finger-containing domain C1_1 PF00130.20 NM_001322915.1_2 - 0.00028 20.6 62.9 0.21 11.4 1.4 9.9 3 1 7 10 10 10 4 Phorbol esters/diacylglycerol binding domain (C1 domain) CpXC PF14353.4 NM_001322915.1_2 - 0.00032 20.6 60.6 3.8 7.4 0.1 13.2 7 4 3 10 10 10 3 CpXC protein GATA PF00320.25 NM_001322915.1_2 - 0.00087 18.7 53.4 1.2 8.7 0.1 12.5 12 2 1 13 13 13 3 GATA zinc finger Zn_Tnp_IS1595 PF12760.5 NM_001322915.1_2 - 0.011 15.6 4.2 0.011 15.6 4.2 9.6 5 2 6 12 12 12 0 Transposase zinc-ribbon domain PHD PF00628.27 NM_001322915.1_2 - 0.015 15.1 2.1 0.015 15.1 2.1 8.4 5 2 1 8 8 8 0 PHD-finger zf-LYAR PF08790.9 NM_001322915.1_2 - 0.26 11.1 62.0 2.6 7.9 0.2 14.7 15 0 0 15 15 15 0 LYAR-type C2HC zinc finger FYVE PF01363.19 NM_001322915.1_2 - 0.28 11.2 65.8 0.77 9.8 5.6 6.4 3 1 0 4 4 3 0 FYVE zinc finger FYDLN_acid PF09538.8 NM_001322915.1_2 - 0.35 11.4 36.9 29 5.3 0.1 11.2 2 2 7 10 10 10 0 Protein of unknown function (FYDLN_acid) C1_4 PF07975.10 NM_001322915.1_2 - 0.38 10.9 65.9 3.1 8.0 2.1 9.6 2 2 7 11 11 11 0 TFIIH C1-like domain ADK_lid PF05191.12 NM_001322915.1_2 - 0.49 10.3 55.1 0.032 14.1 2.4 9.3 5 3 4 9 9 9 0 Adenylate kinase, active site lid zf-C2H2_jaz PF12171.6 NM_001322915.1_2 - 1 9.6 67.5 1.5 9.1 0.1 12.4 12 0 0 12 12 12 0 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001322915.1_2 - 1.1 9.3 72.1 5.1 7.1 0.0 14.4 16 0 0 16 16 15 0 XPA protein N-terminal HypA PF01155.17 NM_001322915.1_2 - 2.3 8.2 58.1 6.7 6.6 1.3 7.8 1 1 6 7 7 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA YhfH PF14149.4 NM_001322915.1_2 - 2.5 8.0 61.5 24 4.8 0.2 13.2 13 0 0 13 13 13 0 YhfH-like protein Chordopox_RPO7 PF05864.10 NM_001322915.1_2 - 6.8 6.9 13.3 12 6.1 0.0 6.9 9 0 0 9 9 8 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) DNA_RNApol_7kD PF03604.11 NM_001322915.1_2 - 8.9 5.9 60.7 8.6 6.0 0.1 13.4 14 0 0 14 14 14 0 DNA directed RNA polymerase, 7 kDa subunit PSI_integrin PF17205.1 NM_001282389.1_2 - 3.4e-08 33.0 5.5 8.1e-08 31.8 5.5 1.6 1 0 0 1 1 1 1 Integrin plexin domain Integrin_beta PF00362.16 NM_001282389.1_3 - 1.1e-109 365.7 0.0 1.5e-109 365.3 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 NM_001282389.1_3 - 7.9e-20 70.1 0.1 1.4e-19 69.3 0.1 1.5 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 NM_001282389.1_3 - 1.2e-16 60.9 6.3 1.2e-16 60.9 6.3 3.0 3 1 0 3 3 3 1 Integrin beta tail domain EGF_2 PF07974.11 NM_001282389.1_3 - 1.5e-10 41.1 86.2 0.00013 22.1 17.1 6.1 4 1 1 5 5 5 4 EGF-like domain Pkinase_Tyr PF07714.15 NM_022963.3_3 - 1.5e-100 335.6 0.0 1.9e-100 335.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_022963.3_3 - 7e-43 146.7 0.0 9.6e-43 146.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.4 NM_022963.3_3 - 4.8e-33 113.5 0.0 2.3e-13 50.4 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_022963.3_3 - 3.6e-31 106.9 0.0 9.1e-14 51.2 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_022963.3_3 - 1.6e-22 79.5 0.0 7.6e-10 38.9 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_022963.3_3 - 1.2e-18 66.9 0.0 3.1e-09 36.7 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 NM_022963.3_3 - 1.2e-14 54.3 0.4 0.0019 18.2 0.1 6.0 3 3 1 4 4 4 3 Immunoglobulin V-set domain APH PF01636.21 NM_022963.3_3 - 0.0015 18.4 0.0 1.2 8.9 0.0 3.2 3 0 0 3 3 3 1 Phosphotransferase enzyme family C2-set_2 PF08205.10 NM_022963.3_3 - 0.024 14.6 0.0 0.1 12.6 0.0 2.1 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 NM_022963.3_3 - 0.037 13.9 0.0 15 5.6 0.0 3.0 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Kinase-like PF14531.4 NM_022963.3_3 - 0.057 12.6 0.0 0.17 11.1 0.0 1.6 2 0 0 2 2 2 0 Kinase-like CUB PF00431.18 NM_001031849.2_1 - 1.1e-52 176.8 0.2 2.5e-31 108.1 0.0 2.5 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 NM_001031849.2_1 - 1.7e-10 41.2 0.5 1.7e-10 41.2 0.5 2.0 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 NM_001031849.2_1 - 4.5e-09 36.3 11.4 5.9e-08 32.7 9.0 3.0 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 NM_001031849.2_1 - 2e-05 24.5 11.1 2.9e-05 24.1 9.4 2.2 2 0 0 2 2 2 1 Calcium-binding EGF domain cEGF PF12662.5 NM_001031849.2_1 - 0.00077 19.2 5.4 0.004 16.9 3.8 2.9 2 0 0 2 2 2 1 Complement Clr-like EGF-like CUB_2 PF02408.18 NM_001031849.2_1 - 0.0022 17.6 0.1 1.2 8.8 0.0 2.4 2 0 0 2 2 2 2 CUB-like domain zf-C2H2 PF00096.24 NM_014374.3_2 - 3.8e-66 215.9 107.2 1.2e-07 31.7 0.3 15.4 15 0 0 15 15 15 15 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_014374.3_2 - 9.2e-59 193.3 95.5 4.9e-09 36.1 0.7 15.8 17 1 1 18 18 16 10 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_014374.3_2 - 2.8e-39 130.2 107.6 0.0012 19.3 0.4 15.7 15 0 0 15 15 15 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_014374.3_2 - 1.6e-15 56.5 83.2 0.01 15.7 0.1 15.5 15 0 0 15 15 15 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_014374.3_2 - 1e-11 44.6 59.2 0.016 15.2 1.9 9.7 7 1 0 9 9 9 6 Zinc ribbon domain FYDLN_acid PF09538.8 NM_014374.3_2 - 3e-05 24.5 32.8 10 6.7 0.3 10.8 4 3 5 10 10 10 0 Protein of unknown function (FYDLN_acid) zf-C2H2_8 PF15909.3 NM_014374.3_2 - 0.00066 19.8 47.8 0.15 12.2 3.2 9.0 3 3 6 9 9 9 3 C2H2-type zinc ribbon zf-met PF12874.5 NM_014374.3_2 - 0.00086 19.5 70.3 0.24 11.7 0.4 14.2 14 0 0 14 14 14 2 Zinc-finger of C2H2 type zf-LYAR PF08790.9 NM_014374.3_2 - 0.001 18.8 41.0 5.3 6.9 0.1 12.1 14 0 0 14 14 13 2 LYAR-type C2HC zinc finger ADK_lid PF05191.12 NM_014374.3_2 - 0.0053 16.6 35.3 1.1 9.2 0.1 9.8 4 4 7 11 11 10 2 Adenylate kinase, active site lid DZR PF12773.5 NM_014374.3_2 - 0.0093 15.8 65.0 37 4.3 9.4 9.3 3 3 3 6 6 5 0 Double zinc ribbon zf-C2H2_11 PF16622.3 NM_014374.3_2 - 0.03 13.9 0.1 0.03 13.9 0.1 12.3 14 0 0 14 14 13 0 zinc-finger C2H2-type zf-Di19 PF05605.10 NM_014374.3_2 - 0.13 12.4 57.9 0.035 14.3 1.1 8.1 5 3 3 9 9 9 0 Drought induced 19 protein (Di19), zinc-binding HypA PF01155.17 NM_014374.3_2 - 0.14 12.1 41.6 0.88 9.5 0.1 8.1 3 3 5 8 8 8 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 NM_014374.3_2 - 0.17 12.6 36.8 5.2 7.7 0.9 7.7 4 3 4 8 8 8 0 zinc-ribbon family DUF3268 PF11672.6 NM_014374.3_2 - 0.49 10.6 18.8 1.4 9.2 0.3 5.4 4 2 1 6 6 6 0 zinc-finger-containing domain zf-C2H2_jaz PF12171.6 NM_014374.3_2 - 0.53 10.5 45.8 0.33 11.2 0.1 12.6 14 0 0 14 14 14 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 NM_014374.3_2 - 7.9 6.4 47.9 23 4.9 1.0 12.2 7 4 1 9 9 9 0 CpXC protein SH2 PF00017.22 NM_001303429.1_1 - 1.1e-40 137.4 0.0 1.5e-19 69.7 0.0 2.4 2 0 0 2 2 2 2 SH2 domain PI3K_P85_iSH2 PF16454.3 NM_001303429.1_1 - 4.9e-29 100.8 18.9 4.6e-28 97.7 14.9 2.1 1 1 1 2 2 2 2 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain IncA PF04156.12 NM_001303429.1_1 - 0.037 13.7 8.6 0.056 13.1 8.6 1.1 1 0 0 1 1 1 0 IncA protein Laminin_I PF06008.12 NM_001303429.1_1 - 0.11 12.1 2.4 0.16 11.5 2.4 1.1 1 0 0 1 1 1 0 Laminin Domain I Mod_r PF07200.11 NM_001303429.1_1 - 0.12 12.4 6.0 0.19 11.7 6.0 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Transcrip_act PF04949.11 NM_001303429.1_1 - 0.35 10.6 7.0 0.75 9.5 1.2 2.1 1 1 1 2 2 2 0 Transcriptional activator Toxin_14 PF07829.9 NM_001303429.1_3 - 2.9 7.8 6.0 8.1 6.4 1.3 2.9 2 0 0 2 2 2 0 Alpha-A conotoxin PIVA-like protein Interfer-bind PF09294.8 NM_001278724.1_1 - 2.2e-16 59.9 0.7 3.8e-16 59.2 0.7 1.3 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.15 NM_001278724.1_3 - 4.9e-12 45.5 0.0 8.4e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 Tissue factor RRM_1 PF00076.20 NM_024811.3_1 - 1.1e-05 25.1 0.0 2e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OAD_gamma PF04277.11 NM_024811.3_1 - 1.8 9.1 3.1 4.6 7.8 3.1 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain OAD_gamma PF04277.11 NM_024811.3_3 - 2.6 8.6 4.1 4.5 7.8 4.1 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain An_peroxidase PF03098.13 NM_175721.3_2 - 1.7e-180 601.0 0.0 2e-180 600.7 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase Sushi PF00084.18 NM_175721.3_2 - 9.3e-07 29.2 2.6 2.1e-06 28.1 2.6 1.6 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Glyco_transf_54 PF04666.11 NM_013244.3_3 - 1.2e-93 313.1 3.0 1.8e-93 312.4 3.0 1.2 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region ATP-synt_ab_Xtn PF16886.3 NM_013244.3_3 - 0.077 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 ATPsynthase alpha/beta subunit N-term extension ALG3 PF05208.11 NM_001006941.2_3 - 5.4e-137 456.9 13.1 6.9e-137 456.6 13.1 1.0 1 0 0 1 1 1 1 ALG3 protein EpsG PF14897.4 NM_001006941.2_3 - 0.00032 20.0 14.4 0.00063 19.0 14.4 1.5 1 1 0 1 1 1 1 EpsG family DUF4418 PF14387.4 NM_001006941.2_3 - 1.6 8.9 8.4 5.9 7.0 0.8 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF4418) zf-H2C2_2 PF13465.4 NM_001165885.1_3 - 4e-157 504.2 135.4 4.6e-08 33.0 0.2 25.5 25 0 0 25 25 25 23 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001165885.1_3 - 1.9e-124 399.5 163.1 8.8e-07 28.9 2.4 24.8 24 0 0 24 24 24 24 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001165885.1_3 - 9e-68 218.9 161.1 0.0014 19.2 2.5 24.9 24 0 0 24 24 24 24 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001165885.1_3 - 6.2e-33 112.0 142.7 0.00045 20.0 0.2 24.3 24 0 0 24 24 24 16 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001165885.1_3 - 2.1e-19 69.2 104.1 0.011 15.7 1.6 13.6 7 3 6 14 14 14 13 Zinc ribbon domain C1_4 PF07975.10 NM_001165885.1_3 - 1.3e-08 34.8 105.4 0.052 13.7 2.5 15.0 6 4 10 16 16 16 6 TFIIH C1-like domain zf-C2H2_jaz PF12171.6 NM_001165885.1_3 - 1.8e-06 27.9 129.3 0.082 13.1 0.6 21.3 22 2 2 24 24 24 6 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 NM_001165885.1_3 - 1.8e-06 27.8 84.6 1.9 8.4 0.4 21.0 6 3 11 20 20 20 5 CpXC protein DUF3268 PF11672.6 NM_001165885.1_3 - 0.062 13.5 79.1 1.9 8.7 0.5 11.6 7 2 3 14 14 14 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 NM_001165885.1_3 - 0.36 11.5 104.1 0.83 10.3 1.4 12.4 1 1 13 15 15 15 0 zinc-ribbon family MIF PF01187.16 NM_002415.1_2 - 3.8e-51 172.1 0.0 4.6e-51 171.8 0.0 1.1 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Kelch_1 PF01344.23 NM_002415.1_2 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Kelch motif CHGN PF05679.14 NM_001319656.1_1 - 6.8e-29 101.0 0.2 8.7e-29 100.6 0.2 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.12 NM_001319656.1_1 - 5.7e-08 32.2 0.6 1.1e-07 31.2 0.6 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase CHGN PF05679.14 NM_001319656.1_2 - 2.2e-19 69.6 1.1 3.2e-19 69.0 1.1 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase KfrA_N PF11740.6 NM_001319656.1_2 - 0.004 17.7 1.2 0.0057 17.2 1.2 1.2 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term Atg14 PF10186.7 NM_001319656.1_2 - 0.44 9.4 2.8 1.3 7.9 1.6 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.12 NM_001319656.1_2 - 2.9 7.8 7.8 4.8 7.0 7.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) WD40 PF00400.30 NM_001033520.1_2 - 0.00095 19.8 0.0 16 6.4 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001033520.1_2 - 0.078 13.2 0.0 0.91 9.7 0.0 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WSK PF03832.11 NM_005100.3_1 - 8.3e-32 108.4 25.2 1.9e-12 46.5 5.5 4.4 3 0 0 3 3 3 3 WSK motif RII_binding_1 PF10522.7 NM_005100.3_1 - 0.00013 21.7 0.3 0.00039 20.2 0.3 1.9 1 0 0 1 1 1 1 RII binding domain zf-H2C2_2 PF13465.4 NM_018675.2_2 - 1e-76 250.0 89.0 5.3e-09 36.0 0.6 15.1 14 2 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_018675.2_2 - 1.1e-45 151.4 99.2 1.5e-05 25.0 0.3 13.8 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_018675.2_2 - 5.3e-27 92.0 90.8 0.023 15.4 0.3 13.7 13 0 0 13 13 13 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_018675.2_2 - 3.2e-19 68.3 73.9 0.00056 19.7 0.5 13.4 13 0 0 13 13 13 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_018675.2_2 - 1.5e-07 31.3 46.6 0.034 14.1 3.3 8.3 5 3 5 10 10 10 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_018675.2_2 - 0.0026 17.9 59.6 0.29 11.4 0.4 11.1 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding FYVE PF01363.19 NM_018675.2_2 - 0.0087 16.1 55.2 0.0088 16.0 3.2 6.0 2 2 2 4 4 4 3 FYVE zinc finger XPA_N PF01286.16 NM_018675.2_2 - 0.035 14.0 46.1 7.4 6.6 0.0 10.8 12 0 0 12 12 12 0 XPA protein N-terminal KRAB PF01352.25 NM_018675.2_3 - 1.8e-23 81.8 0.3 3.7e-23 80.8 0.3 1.6 1 0 0 1 1 1 1 KRAB box Pkinase PF00069.23 NM_001134419.1_3 - 1.2e-46 159.0 0.0 6.8e-25 87.8 0.1 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001134419.1_3 - 3.8e-15 55.7 0.0 4.2e-12 45.8 0.1 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.21 NM_001134419.1_3 - 0.054 13.3 0.0 0.17 11.6 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family TCR PF03638.13 NM_001134419.1_3 - 3.9 7.7 10.3 8.6 6.6 0.4 2.7 2 0 0 2 2 2 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain Cation_ATPase_C PF00689.19 NM_001684.4_1 - 6e-44 149.8 2.9 6e-44 149.8 2.9 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.18 NM_001684.4_1 - 8.5e-39 133.0 4.2 3.7e-26 91.7 0.6 2.4 2 0 0 2 2 2 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.6 NM_001684.4_1 - 1.8e-26 92.2 0.6 1.8e-26 92.2 0.6 2.5 2 0 0 2 2 2 1 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.4 NM_001684.4_1 - 1.5e-19 69.8 0.0 2.6e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 NM_001684.4_1 - 1.1e-16 60.0 0.1 4.9e-16 58.0 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 NM_001684.4_1 - 2.9e-14 53.7 0.0 9.6e-12 45.5 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 NM_001684.4_1 - 3.8e-06 26.7 0.3 0.00046 19.9 0.3 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ART PF01129.16 NM_021071.2_1 - 3.2e-51 173.6 1.1 3.9e-51 173.3 1.1 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase DUF4200 PF13863.4 NM_144681.2_3 - 1.9e-24 86.2 27.1 1.9e-24 86.2 27.1 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF4200) RRM_1 PF00076.20 NM_031210.5_3 - 3.6e-13 49.0 0.0 5e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) P2X_receptor PF00864.17 NM_170682.3_2 - 2.4e-145 484.1 0.1 3.1e-145 483.7 0.1 1.0 1 0 0 1 1 1 1 ATP P2X receptor RRM_1 PF00076.20 NM_001100393.1_1 - 7.2e-11 41.6 0.0 1.2e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XhlA PF10779.7 NM_001100393.1_1 - 0.077 13.1 6.0 0.13 12.4 6.0 1.3 1 0 0 1 1 1 0 Haemolysin XhlA ORF11CD3 PF10549.7 NM_001100393.1_1 - 1.2 9.1 4.6 3.8 7.6 1.8 2.2 2 0 0 2 2 2 0 ORF11CD3 domain SPT_ssu-like PF11779.6 NM_138288.3_2 - 8.1e-19 66.9 7.1 8.1e-19 66.9 7.1 2.2 2 0 0 2 2 2 1 Small subunit of serine palmitoyltransferase-like Ig_3 PF13927.4 NM_001160331.1_1 - 5.5e-75 247.9 0.0 5.6e-14 52.4 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 NM_001160331.1_1 - 1.2e-70 233.4 0.0 7.9e-14 51.4 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001160331.1_1 - 7.4e-48 160.7 0.0 8.3e-09 35.5 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 NM_001160331.1_1 - 1.5e-39 133.9 0.0 1.3e-06 28.4 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.19 NM_001160331.1_1 - 2e-35 120.8 14.4 1.1e-10 41.5 0.1 4.5 4 0 0 4 4 4 4 Fibronectin type III domain Bravo_FIGEY PF13882.4 NM_001160331.1_1 - 3.1e-27 95.6 5.2 8.1e-27 94.3 5.2 1.8 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.15 NM_001160331.1_1 - 4e-16 59.0 3.7 0.0023 17.9 0.0 8.4 7 3 1 8 8 8 3 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_001160331.1_1 - 4e-09 36.7 0.0 0.033 14.5 0.0 4.1 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 NM_001160331.1_1 - 7.5e-07 29.0 0.1 1 9.4 0.0 5.4 6 0 0 6 6 6 2 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.10 NM_001160331.1_1 - 0.0034 17.3 0.0 0.11 12.4 0.0 2.9 2 0 0 2 2 2 1 Penicillin-Binding Protein C-terminus Family Izumo-Ig PF16706.3 NM_001160331.1_1 - 0.0061 16.4 0.2 17 5.4 0.0 3.5 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 NM_001160331.1_1 - 0.11 12.6 0.1 13 5.9 0.0 2.6 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 Kazal_1 PF00050.19 NM_032566.2_1 - 6.6e-15 54.7 2.6 1e-14 54.1 2.6 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 NM_032566.2_1 - 3.8e-13 49.3 2.3 6e-13 48.6 2.3 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1 PF07690.14 NM_207113.2_2 - 1.9e-36 125.6 30.2 2.8e-33 115.2 18.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_207113.2_2 - 1.3e-05 24.1 28.5 0.0059 15.4 11.4 3.1 2 1 1 3 3 3 3 Sugar (and other) transporter zf-H2C2_2 PF13465.4 NM_001145446.1_2 - 4.9e-25 86.7 36.3 1.9e-08 34.3 0.7 6.4 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001145446.1_2 - 2.3e-20 71.7 40.4 2.8e-05 24.2 0.8 6.0 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001145446.1_2 - 1.7e-10 40.6 42.4 0.0032 18.0 0.6 6.3 6 0 0 6 6 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001145446.1_2 - 3e-06 27.3 16.8 0.02 15.1 0.2 4.5 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001145446.1_2 - 0.00026 21.5 12.4 0.046 14.3 0.6 3.6 1 1 2 3 3 3 3 zinc-ribbon family Zn-ribbon_8 PF09723.8 NM_001145446.1_2 - 0.00051 20.0 22.5 0.047 13.7 3.2 4.0 1 1 4 5 5 5 5 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001145446.1_2 - 0.00059 19.6 37.1 0.091 12.6 0.3 6.0 6 0 0 6 6 5 4 C2H2-type zinc finger zf-met PF12874.5 NM_001145446.1_2 - 0.00068 19.8 15.1 0.33 11.2 0.7 3.8 3 0 0 3 3 3 2 Zinc-finger of C2H2 type DZR PF12773.5 NM_001145446.1_2 - 0.0022 17.9 15.7 0.45 10.5 7.1 3.2 1 1 1 2 2 2 2 Double zinc ribbon KRAB PF01352.25 NM_001145446.1_2 - 0.031 13.8 0.2 0.063 12.8 0.2 1.5 1 0 0 1 1 1 0 KRAB box DUF2709 PF10915.6 NM_001145446.1_2 - 0.083 12.0 0.1 3.4 6.7 0.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2709) zf-Di19 PF05605.10 NM_001145446.1_2 - 0.25 11.6 19.5 0.61 10.3 0.2 3.5 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.4 NM_001145446.1_2 - 0.31 10.9 0.1 0.31 10.9 0.1 5.6 5 0 0 5 5 5 0 zinc-finger of a C2HC-type DUF3268 PF11672.6 NM_001145446.1_2 - 1.9 8.7 11.0 3.3 7.9 1.6 2.9 1 1 1 3 3 3 0 zinc-finger-containing domain YhfH PF14149.4 NM_001145446.1_2 - 4.7 7.1 15.8 26 4.8 0.0 5.2 5 0 0 5 5 5 0 YhfH-like protein HypA PF01155.17 NM_001145446.1_2 - 5.2 7.0 14.1 3.5 7.5 4.2 3.1 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.10 NM_001145446.1_2 - 6.9 6.6 19.3 5.9 6.8 4.1 3.6 2 1 1 3 3 3 0 zinc-ribbons zf-LYAR PF08790.9 NM_001145446.1_2 - 9.4 6.1 21.4 1.4 8.7 0.2 4.9 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger CybS PF05328.10 NM_003002.3_1 - 1.3e-22 79.8 0.5 1.9e-22 79.3 0.5 1.2 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Serpin PF00079.18 NM_000295.4_1 - 1.5e-117 392.9 2.2 1.8e-117 392.7 2.2 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ctr PF04145.13 NM_001860.2_1 - 2.4e-28 99.5 2.9 3.5e-28 98.9 2.9 1.2 1 0 0 1 1 1 1 Ctr copper transporter family TRC8_N PF13705.4 NM_001199380.1_1 - 6.1e-152 506.9 46.4 7.7e-152 506.5 46.4 1.1 1 0 0 1 1 1 1 TRC8 N-terminal domain zf-RING_2 PF13639.4 NM_001199380.1_1 - 5.1e-10 39.3 7.3 5.1e-10 39.3 7.3 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_001199380.1_1 - 2.4e-08 33.6 6.9 2.4e-08 33.6 6.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_001199380.1_1 - 1.3e-07 31.6 6.6 3.3e-07 30.4 6.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 NM_001199380.1_1 - 5.2e-06 26.2 3.2 1.3e-05 24.9 3.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_001199380.1_1 - 1.1e-05 25.0 6.3 1.1e-05 25.0 6.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001199380.1_1 - 1.6e-05 24.5 9.0 1.6e-05 24.5 9.0 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_001199380.1_1 - 3.2e-05 23.6 9.2 0.00011 21.9 9.2 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.3 NM_001199380.1_1 - 0.00017 21.1 4.6 0.00059 19.4 4.6 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.4 NM_001199380.1_1 - 0.0051 16.6 10.1 0.0051 16.6 10.1 2.2 2 0 0 2 2 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 NM_001199380.1_1 - 0.011 15.7 5.8 0.025 14.5 5.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.5 NM_001199380.1_1 - 0.081 12.9 5.2 0.25 11.3 5.2 1.9 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.3 NM_001199380.1_1 - 1.3 8.5 14.9 0.65 9.5 9.8 2.6 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type WD40 PF00400.30 NM_001143990.1_3 - 6.8e-18 64.6 11.1 0.00022 21.8 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001143990.1_3 - 0.00048 20.2 0.0 14 5.9 0.0 4.8 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Fibrinogen_C PF00147.16 NM_001146.4_3 - 2.3e-69 233.4 5.8 3.4e-69 232.9 5.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4239 PF14023.4 NM_001146.4_3 - 0.9 9.1 7.1 0.68 9.5 5.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) Guanylate_cyc_2 PF09778.7 NM_001284253.1_3 - 1.1e-67 227.4 2.2 2e-43 148.1 0.7 2.1 1 1 1 2 2 2 2 Guanylylate cyclase Peptidase_C70 PF12385.6 NM_001284253.1_3 - 9e-06 25.6 0.0 4.7e-05 23.2 0.0 1.9 1 1 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 Peptidase_C39_2 PF13529.4 NM_001284253.1_3 - 0.00067 20.1 0.0 0.0017 18.8 0.0 1.6 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C39 PF03412.13 NM_001284253.1_3 - 0.024 14.3 0.0 0.19 11.4 0.0 2.0 2 0 0 2 2 2 0 Peptidase C39 family Citrate_bind PF16114.3 NM_001303274.1_3 - 3.8e-92 306.5 0.1 6.4e-92 305.8 0.1 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.19 NM_001303274.1_3 - 3.9e-22 78.7 0.0 4.2e-19 68.7 0.0 2.9 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.17 NM_001303274.1_3 - 1.4e-13 50.8 0.0 2.5e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.17 NM_001303274.1_3 - 6.3e-12 45.9 0.0 1.3e-11 44.9 0.0 1.6 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.8 NM_001303274.1_3 - 3.6e-05 23.3 0.0 6.4e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.4 NM_001303274.1_3 - 0.0013 18.4 0.0 0.0038 16.9 0.0 1.8 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain zf-met PF12874.5 NM_001242704.1_1 - 2.1e-20 72.3 19.2 3e-07 30.5 2.8 3.9 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001242704.1_1 - 4.9e-15 55.3 17.6 6.7e-05 23.0 2.0 3.5 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 NM_001242704.1_1 - 1.4e-07 31.6 10.1 0.0072 16.5 0.9 3.3 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.10 NM_001242704.1_1 - 0.0025 17.9 8.4 0.0055 16.8 0.3 3.0 3 0 0 3 3 3 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2 PF00096.24 NM_001242704.1_1 - 0.024 15.0 14.8 2 8.9 0.4 4.4 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_9 PF16293.3 NM_001242704.1_1 - 0.024 14.3 5.1 3 7.6 0.1 3.3 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) DUF1921 PF09081.8 NM_001242704.1_1 - 0.14 12.3 0.2 0.32 11.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1921) zf-U1 PF06220.10 NM_001242704.1_1 - 0.57 9.9 9.3 7.2 6.3 0.1 3.5 3 0 0 3 3 3 0 U1 zinc finger zf-C2H2_4 PF13894.4 NM_001242704.1_1 - 0.64 10.9 14.3 7.9 7.5 0.6 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger CTU2 PF10288.7 NM_001242704.1_1 - 2.7 8.1 9.6 32 4.7 0.1 3.0 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 CD52 PF15116.4 NM_001242704.1_3 - 0.15 12.0 0.4 0.39 10.7 0.4 1.7 1 0 0 1 1 1 0 CAMPATH-1 antigen E3_UbLigase_R4 PF13764.4 NM_020765.2_2 - 0 1132.2 0.0 0 1131.0 0.0 1.7 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase UBR4 zf-UBR PF02207.18 NM_020765.2_2 - 1.3e-06 28.4 14.8 1.3e-06 28.4 14.8 3.0 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) UPF0547 PF10571.7 NM_020765.2_2 - 0.44 10.5 6.8 2.4 8.2 6.8 2.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 DUF4820 PF16091.3 NM_020765.2_2 - 0.48 9.6 5.4 0.22 10.8 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) FAM176 PF14851.4 NM_020765.2_2 - 3.7 7.1 9.9 18 4.8 0.1 4.0 3 0 0 3 3 3 0 FAM176 family SBF_like PF13593.4 NM_001317818.1_3 - 9.1e-08 31.6 0.1 1.2e-07 31.3 0.1 1.1 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Semenogelin PF05474.9 NM_003007.4_1 - 4.4e-251 834.4 72.5 1.5e-196 654.3 48.7 2.0 1 1 1 2 2 2 2 Semenogelin Ribosomal_L40e PF01020.15 NM_003007.4_2 - 0.072 12.8 6.0 2.2 8.1 0.2 3.1 3 0 0 3 3 3 0 Ribosomal L40e family 7tm_1 PF00001.19 NM_005283.2_3 - 1.4e-40 139.2 29.2 3.2e-40 137.9 29.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Arm PF00514.21 NM_001286609.1_3 - 4.2e-06 26.5 13.9 1.2 9.2 0.0 8.8 10 0 0 10 10 10 4 Armadillo/beta-catenin-like repeat KAP PF05804.10 NM_001286609.1_3 - 0.01 13.9 15.0 0.14 10.1 3.8 3.0 1 1 0 3 3 3 0 Kinesin-associated protein (KAP) FKBP_C PF00254.26 NM_001302960.1_2 - 5.7e-09 36.0 0.0 1.1e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.15 NM_001302960.1_3 - 0.00042 20.1 0.4 0.00099 18.9 0.4 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001302960.1_3 - 0.076 13.1 1.9 0.19 11.9 0.1 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DEADboxA PF12343.6 NM_001167740.1_2 - 0.036 14.4 6.7 0.11 12.9 6.7 1.9 1 0 0 1 1 1 0 Cold shock protein DEAD box A SET PF00856.26 NM_001167740.1_3 - 2.4e-16 60.4 0.0 4.8e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.16 NM_001167740.1_3 - 4.7e-10 39.3 12.9 4.7e-10 39.3 12.9 3.3 3 0 0 3 3 3 1 MYND finger ABC_membrane PF00664.21 NM_000352.4_1 - 2.2e-84 283.2 40.7 4.6e-48 164.1 7.8 2.9 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.25 NM_000352.4_1 - 3.9e-46 156.8 0.2 3.4e-23 82.6 0.0 3.7 4 0 0 4 4 4 2 ABC transporter SMC_N PF02463.17 NM_000352.4_1 - 2e-07 30.5 3.1 0.017 14.4 0.0 4.0 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 NM_000352.4_1 - 0.00052 19.5 0.4 0.17 11.5 0.0 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.4 NM_000352.4_1 - 0.00052 19.8 3.8 1.9 8.1 0.1 4.1 4 1 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.4 NM_000352.4_1 - 0.0043 16.5 0.0 0.23 10.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain ATPase PF06745.11 NM_000352.4_1 - 0.0056 15.9 0.5 0.49 9.6 0.1 2.4 2 0 0 2 2 2 1 KaiC DUF258 PF03193.14 NM_000352.4_1 - 0.0081 15.9 0.2 0.31 10.8 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC_ATPase PF09818.7 NM_000352.4_1 - 0.0084 14.8 0.8 0.36 9.4 0.0 2.8 3 1 0 3 3 3 1 Predicted ATPase of the ABC class MMR_HSR1 PF01926.21 NM_000352.4_1 - 0.013 15.5 0.0 3.4 7.7 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_22 PF13401.4 NM_000352.4_1 - 0.043 14.0 1.2 6.3 6.9 0.1 3.0 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 NM_000352.4_1 - 0.065 12.4 0.1 0.5 9.5 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin AAA_24 PF13479.4 NM_000352.4_1 - 0.089 12.4 0.6 0.47 10.0 0.1 2.3 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.23 NM_000352.4_1 - 0.19 11.2 0.0 6.2 6.3 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_16 PF13191.4 NM_000352.4_1 - 0.9 9.8 3.3 1.3 9.3 0.0 2.9 4 0 0 4 4 2 0 AAA ATPase domain AAA_23 PF13476.4 NM_000352.4_1 - 1.7 9.0 9.6 28 5.0 0.2 3.0 2 1 0 2 2 2 0 AAA domain DUF3682 PF12446.6 NM_000352.4_1 - 5.9 7.2 6.2 12 6.3 6.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) DUF5134 PF17197.2 NM_000352.4_1 - 6.9 6.4 7.5 0.28 10.9 0.3 2.4 2 1 0 2 2 1 0 Domain of unknown function (DUF5134) AA_kinase PF00696.26 NM_001323412.1_1 - 1.2e-32 113.3 0.1 2.2e-32 112.4 0.1 1.4 1 0 0 1 1 1 1 Amino acid kinase family Aldedh PF00171.20 NM_001323412.1_1 - 9.1e-12 44.1 0.0 9e-09 34.2 0.0 2.3 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Uteroglobin PF01099.15 NM_003357.4_2 - 9.8e-20 70.4 0.1 1.5e-19 69.8 0.1 1.3 1 0 0 1 1 1 1 Uteroglobin family Nop14 PF04147.10 NM_003357.4_2 - 0.095 10.8 0.3 0.11 10.6 0.3 1.0 1 0 0 1 1 1 0 Nop14-like family E3_UbLigase_R4 PF13764.4 NM_003357.4_2 - 0.16 10.0 0.1 0.19 9.7 0.1 1.0 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 SHMT PF00464.17 NM_148918.2_2 - 8e-185 614.0 0.0 1.9e-134 448.1 0.0 2.1 1 1 1 2 2 2 2 Serine hydroxymethyltransferase SWIM PF04434.15 NM_015037.3_1 - 0.012 15.1 6.3 0.026 14.1 6.3 1.5 1 0 0 1 1 1 0 SWIM zinc finger FAST_2 PF08368.10 NM_001322046.1_1 - 1.7e-25 89.5 0.4 2.6e-23 82.5 0.0 2.7 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.13 NM_001322046.1_1 - 4.1e-23 81.0 7.2 4.1e-21 74.5 0.2 4.2 3 1 1 4 4 4 2 FAST kinase-like protein, subdomain 1 RAP PF08373.8 NM_001322046.1_1 - 2.2e-14 53.2 0.1 4.5e-13 48.9 0.0 2.6 2 0 0 2 2 2 1 RAP domain Abhydrolase_1 PF00561.18 NM_001253900.1_2 - 1.2e-16 61.0 0.1 1.1e-14 54.6 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_001253900.1_2 - 6.6e-10 39.8 0.1 6.6e-10 39.8 0.1 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF1057 PF06342.10 NM_001253900.1_2 - 0.00018 20.5 0.0 0.00025 20.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Hydrolase_4 PF12146.6 NM_001253900.1_2 - 0.00035 19.8 0.0 0.0045 16.1 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 REV PF00424.16 NM_001253900.1_2 - 0.02 14.8 0.0 0.3 11.0 0.0 2.2 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Methyltransf_11 PF08241.10 NM_020844.2_1 - 1.2e-15 57.7 0.0 2.3e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_020844.2_1 - 1.1e-14 54.7 0.0 2e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_020844.2_1 - 7.2e-09 35.5 0.0 1.1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_020844.2_1 - 2.6e-08 34.4 0.0 4.3e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 NM_020844.2_1 - 7.4e-08 32.4 0.0 3.3e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.16 NM_020844.2_1 - 4.9e-05 22.6 0.0 7.7e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.13 NM_020844.2_1 - 8.4e-05 22.4 0.0 0.00013 21.7 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_9 PF08003.9 NM_020844.2_1 - 0.0064 15.3 0.0 0.021 13.7 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.18 NM_020844.2_1 - 0.027 13.6 0.0 0.057 12.6 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Pkinase_Tyr PF07714.15 NM_014916.3_3 - 4e-55 186.8 0.0 5.5e-55 186.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_014916.3_3 - 9.3e-26 90.6 0.0 1.4e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.12 NM_014916.3_3 - 0.21 10.8 0.1 0.36 10.0 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.23 NM_001128629.2_1 - 1.3e-66 224.6 0.0 2.1e-66 223.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001128629.2_1 - 8e-45 153.0 0.0 1.2e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 NM_001128629.2_1 - 1.1e-15 57.6 0.1 2.3e-15 56.6 0.1 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 NM_001128629.2_1 - 3.4e-07 29.7 0.0 5.2e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001128629.2_1 - 0.094 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4564 PF15169.4 NM_001100408.2_3 - 2.7e-68 229.2 0.2 4.4e-67 225.2 0.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4564) 7tm_4 PF13853.4 NM_001004737.1_1 - 9.6e-47 159.9 20.8 1.2e-46 159.6 20.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004737.1_1 - 1.7e-17 63.4 19.2 3.9e-17 62.2 19.2 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pkinase PF00069.23 NM_001256312.1_2 - 1.1e-70 237.9 0.0 1.6e-70 237.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001256312.1_2 - 2.9e-51 174.1 0.0 4.9e-51 173.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.6 NM_001256312.1_2 - 2.5e-25 88.1 5.1 8.2e-25 86.5 5.1 1.9 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 Abi_2 PF07751.9 NM_001256312.1_2 - 0.036 14.2 0.0 0.091 12.9 0.0 1.7 1 0 0 1 1 1 0 Abi-like protein FLYWCH_N PF15423.4 NM_138439.2_3 - 1.1e-46 157.2 4.2 1.5e-46 156.8 4.2 1.2 1 0 0 1 1 1 1 FLYWCH-type zinc finger-containing protein CC2-LZ PF16516.3 NM_006058.4_2 - 3.7e-07 30.3 21.7 3.7e-07 30.3 21.7 5.8 4 1 1 5 5 5 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF4407 PF14362.4 NM_006058.4_2 - 0.0031 16.8 18.1 0.0031 16.8 18.1 3.2 1 1 2 3 3 3 2 Domain of unknown function (DUF4407) NPV_P10 PF05531.10 NM_006058.4_2 - 7.4 7.0 18.0 7.5 7.0 1.6 4.4 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein APP_E2 PF12925.5 NM_005166.4_1 - 4.7e-68 228.5 4.0 9e-68 227.6 4.0 1.5 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 NM_005166.4_1 - 1.2e-33 115.3 0.0 2e-33 114.6 0.0 1.4 1 0 0 1 1 1 1 Amyloid A4 N-terminal heparin-binding APP_Cu_bd PF12924.5 NM_005166.4_1 - 1.5e-24 86.3 2.1 3.3e-24 85.3 2.1 1.6 1 0 0 1 1 1 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.7 NM_005166.4_1 - 1.3e-21 76.8 0.7 7.2e-21 74.4 0.0 2.5 2 0 0 2 2 2 1 beta-amyloid precursor protein C-terminus IFRD PF05004.11 NM_005166.4_1 - 0.0084 15.1 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) Ints3 PF10189.7 NM_005166.4_1 - 0.078 12.1 0.1 0.12 11.5 0.1 1.2 1 0 0 1 1 1 0 Integrator complex subunit 3 WD40 PF00400.30 NM_001300793.1_1 - 0.0023 18.6 0.4 0.007 17.1 0.4 1.9 1 0 0 1 1 1 1 WD domain, G-beta repeat HELP PF03451.12 NM_001300793.1_3 - 1e-27 95.6 0.0 2.7e-27 94.3 0.0 1.7 1 0 0 1 1 1 1 HELP motif WD40 PF00400.30 NM_001300793.1_3 - 6.5e-21 74.1 24.1 0.00013 22.6 0.2 8.3 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001300793.1_3 - 5.9e-06 26.4 0.0 3.6 7.8 0.0 4.9 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.4 NM_001300793.1_3 - 0.087 12.3 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 PQQ-like domain Tetraspannin PF00335.18 NM_001774.2_2 - 2.6e-45 154.7 9.1 3.5e-45 154.3 9.1 1.2 1 0 0 1 1 1 1 Tetraspanin family Lactamase_B_4 PF13691.4 NM_018127.6_1 - 2e-16 59.3 0.0 5.1e-16 58.0 0.0 1.8 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.5 NM_018127.6_1 - 2.2e-14 53.3 0.1 1.1e-11 44.5 0.6 2.9 3 1 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.25 NM_018127.6_1 - 0.001 19.0 0.6 0.0034 17.3 0.3 2.0 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily LIAS_N PF16881.3 NM_001278591.1_2 - 2.7e-51 172.4 0.1 3.4e-51 172.1 0.1 1.1 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family FAM72 PF14976.4 NM_001317901.1_2 - 1.2e-52 177.7 3.1 1.8e-52 177.2 3.1 1.1 1 0 0 1 1 1 1 FAM72 protein Arm PF00514.21 NM_001282746.1_1 - 1.5e-47 158.1 10.2 1.2e-07 31.4 0.0 10.5 10 0 0 10 10 10 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 NM_001282746.1_1 - 1.1e-28 99.3 9.4 1.3e-08 34.9 0.2 6.8 2 1 5 7 7 7 7 HEAT repeats HEAT PF02985.20 NM_001282746.1_1 - 1.1e-21 74.9 10.9 0.00014 21.6 0.1 9.3 9 0 0 9 9 9 5 HEAT repeat HEAT_EZ PF13513.4 NM_001282746.1_1 - 5e-20 71.4 7.2 5.2e-05 23.5 0.1 8.6 8 1 1 9 9 9 4 HEAT-like repeat V-ATPase_H_C PF11698.6 NM_001282746.1_1 - 5.4e-10 39.3 10.4 0.29 11.1 0.0 6.1 2 2 5 7 7 7 3 V-ATPase subunit H Cnd1 PF12717.5 NM_001282746.1_1 - 1.8e-09 37.7 17.1 0.0014 18.5 0.9 5.4 1 1 5 6 6 6 3 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.6 NM_001282746.1_1 - 5.4e-09 36.0 5.8 0.00029 20.7 0.1 4.3 2 1 2 4 4 4 3 Myosin-binding striated muscle assembly central V-ATPase_H_N PF03224.12 NM_001282746.1_1 - 4.8e-08 32.5 3.1 0.0046 16.2 0.0 3.5 1 1 2 3 3 3 3 V-ATPase subunit H Arm_2 PF04826.11 NM_001282746.1_1 - 0.00019 20.9 12.6 0.12 11.6 0.0 4.6 1 1 1 3 3 3 2 Armadillo-like CLASP_N PF12348.6 NM_001282746.1_1 - 0.00032 20.2 5.0 0.23 10.9 0.0 3.7 3 1 1 4 4 4 2 CLASP N terminal KAP PF05804.10 NM_001282746.1_1 - 0.0044 15.1 8.0 0.011 13.8 4.5 2.3 1 1 1 2 2 2 1 Kinesin-associated protein (KAP) EDR1 PF14381.4 NM_001282746.1_1 - 0.0048 16.5 0.0 0.016 14.8 0.0 1.9 1 0 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 MOR2-PAG1_C PF14225.4 NM_001282746.1_1 - 0.017 14.9 0.7 0.28 10.9 0.0 2.5 1 1 0 2 2 2 0 Cell morphogenesis C-terminal HEAT_PBS PF03130.14 NM_001282746.1_1 - 0.019 15.5 9.6 0.076 13.6 0.5 5.7 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat RasGEF_N_2 PF14663.4 NM_001282746.1_1 - 0.11 12.7 6.9 12 6.1 0.1 5.3 5 2 1 6 6 6 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain IFRD PF05004.11 NM_001282746.1_1 - 0.36 9.8 11.7 8.9 5.2 3.6 4.9 1 1 2 4 4 4 0 Interferon-related developmental regulator (IFRD) RTP1_C1 PF10363.7 NM_001282746.1_1 - 3.3 7.8 5.6 12 6.0 0.6 3.7 3 2 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Abi_HHR PF07815.12 NM_001282932.1_3 - 6.4e-33 112.6 0.3 1.1e-32 111.9 0.3 1.3 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.4 NM_001282932.1_3 - 5.2e-17 61.3 0.2 9.3e-17 60.5 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001282932.1_3 - 2e-15 56.0 0.2 4e-15 55.0 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001282932.1_3 - 6e-12 44.9 0.1 1.1e-11 44.2 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain zf-U11-48K PF05253.10 NM_001008901.1_3 - 3.2e-18 65.1 10.4 1.4e-10 40.7 2.4 2.5 2 0 0 2 2 2 2 U11-48K-like CHHC zinc finger INT_SG_DDX_CT_C PF15300.4 NM_001017438.2_3 - 4.8e-25 87.0 2.0 7.5e-25 86.4 2.0 1.3 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus CD34_antigen PF06365.10 NM_033207.4_2 - 0.14 11.6 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Lectin_N PF03954.12 NM_001201352.1_1 - 1.1e-56 190.0 0.7 1.7e-56 189.4 0.7 1.3 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain Lectin_C PF00059.19 NM_001201352.1_1 - 3e-26 92.1 7.7 5.3e-26 91.3 5.7 2.2 2 0 0 2 2 2 1 Lectin C-type domain ELO PF01151.16 NM_152310.2_2 - 1.1e-65 221.5 21.5 1.5e-65 221.1 21.5 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family RNA_pol_Rpc4 PF05132.12 NM_001722.2_3 - 6.5e-29 101.2 0.1 6.5e-29 101.2 0.1 3.1 3 0 0 3 3 3 1 RNA polymerase III RPC4 Trypsin PF00089.24 NM_015849.2_2 - 2.4e-67 226.9 3.1 2.8e-67 226.6 3.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_015849.2_2 - 1.2e-08 35.9 0.1 1.7e-08 35.4 0.1 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_015849.2_2 - 0.004 17.4 0.3 0.0074 16.5 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Methyltransf_16 PF10294.7 NM_001040662.1_1 - 1.3e-51 174.6 0.0 1.7e-51 174.3 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.4 NM_001040662.1_1 - 0.0098 15.7 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_001040662.1_1 - 0.099 13.2 0.0 0.16 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.13 NM_001040662.1_1 - 0.16 11.5 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 SOBP PF15279.4 NM_001172739.1_3 - 4.2e-09 37.3 31.8 4.2e-09 37.3 31.8 3.1 2 2 0 3 3 3 1 Sine oculis-binding protein HLH PF00010.24 NM_020646.2_1 - 9.8e-16 57.3 2.3 1.4e-15 56.8 2.3 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Cas9-BH PF16593.3 NM_020646.2_1 - 0.017 14.7 0.3 0.044 13.4 0.3 1.7 2 0 0 2 2 2 0 Bridge helix of CRISPR-associated endonuclease Cas9 SIR2_2 PF13289.4 NM_001104595.1_2 - 2.9e-16 59.7 0.0 5.8e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 SIR2-like domain Hydrolase_4 PF12146.6 NM_016014.3_1 - 3.7e-12 45.9 0.0 2.2e-06 27.0 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.19 NM_016014.3_1 - 3.4e-07 29.8 0.0 3.3e-05 23.3 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.5 NM_016014.3_1 - 3.9e-06 27.5 0.0 0.00055 20.5 0.0 2.4 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 NM_016014.3_1 - 5.3e-06 26.1 0.1 0.028 13.9 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.16 NM_016014.3_1 - 0.0026 17.2 0.0 0.0041 16.6 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.11 NM_016014.3_1 - 0.0092 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) UPF0227 PF05728.10 NM_016014.3_1 - 0.01 15.6 0.0 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) DUF818 PF05677.10 NM_016014.3_1 - 0.013 14.4 0.1 0.019 13.8 0.1 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Asp2 PF16929.3 NM_016014.3_1 - 0.033 13.1 0.0 0.048 12.6 0.0 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Abhydrolase_5 PF12695.5 NM_016014.3_1 - 0.085 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 NM_016014.3_1 - 0.14 11.8 0.0 0.83 9.3 0.0 2.0 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase PQ-loop PF04193.12 NM_025078.4_2 - 9.2e-31 105.3 0.1 5.7e-17 61.1 0.0 2.7 2 1 1 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.16 NM_025078.4_2 - 0.00011 22.9 1.0 0.2 12.4 0.2 2.2 2 0 0 2 2 2 2 ER lumen protein retaining receptor SQS_PSY PF00494.17 NM_001287756.1_3 - 1e-16 61.1 0.0 1.5e-16 60.5 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase IRF-3 PF10401.7 NM_001197126.1_2 - 2.4e-51 174.0 0.0 3.2e-51 173.6 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 Complex1_LYR PF05347.13 NM_020466.4_1 - 8.7e-17 60.8 0.6 1.4e-16 60.1 0.6 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 NM_020466.4_1 - 0.00025 21.6 0.5 0.00042 20.9 0.5 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.4 NM_020466.4_1 - 0.028 14.9 0.1 0.049 14.1 0.1 1.3 1 0 0 1 1 1 0 Complex1_LYR-like DUF846 PF05832.10 NM_001316921.1_1 - 7.4e-55 184.7 9.3 7.4e-55 184.7 9.3 2.3 3 0 0 3 3 3 1 Eukaryotic protein of unknown function (DUF846) Bcl-2 PF00452.17 NM_000657.2_2 - 5.1e-32 110.3 0.1 7.6e-32 109.7 0.1 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.15 NM_000657.2_2 - 8.4e-14 50.9 0.3 1.9e-13 49.8 0.3 1.6 1 0 0 1 1 1 1 Bcl-2 homology region 4 Bcl-2_3 PF15286.4 NM_000657.2_2 - 0.0069 16.9 0.0 0.014 16.0 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like RAWUL PF16207.3 NM_032673.2_3 - 2.6e-14 53.5 0.4 7.6e-14 52.0 0.4 1.8 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 NM_032673.2_3 - 2.7e-09 36.6 13.4 3.7e-09 36.1 12.7 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_032673.2_3 - 1.3e-08 34.4 13.4 3.1e-08 33.2 13.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_032673.2_3 - 4.9e-06 26.6 12.5 5.3e-06 26.5 11.2 1.8 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 NM_032673.2_3 - 1.7e-05 24.5 11.8 3.3e-05 23.5 11.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_032673.2_3 - 4.3e-05 23.6 7.2 9.1e-05 22.5 7.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 NM_032673.2_3 - 0.0012 18.6 15.5 0.006 16.4 14.7 2.3 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_032673.2_3 - 0.0017 18.2 9.0 0.0017 18.2 9.0 1.9 2 0 0 2 2 2 1 RING-type zinc-finger Rad60-SLD PF11976.6 NM_032673.2_3 - 0.0018 18.0 0.0 0.0055 16.4 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-Nse PF11789.6 NM_032673.2_3 - 0.01 15.5 6.9 0.02 14.6 6.9 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Atg8 PF02991.14 NM_032673.2_3 - 0.02 15.0 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like zf-ANAPC11 PF12861.5 NM_032673.2_3 - 0.038 13.9 3.8 0.066 13.1 3.8 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 NM_032673.2_3 - 0.073 13.1 13.8 0.16 12.0 13.8 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.4 NM_032673.2_3 - 0.15 11.8 14.7 0.26 11.0 13.1 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 NM_032673.2_3 - 0.53 10.3 10.8 0.29 11.2 8.2 2.0 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-RING_6 PF14835.4 NM_032673.2_3 - 3.3 7.5 8.9 0.24 11.2 3.9 1.7 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Amidinotransf PF02274.15 NM_001134445.1_2 - 0.0017 17.5 0.0 0.0026 16.9 0.0 1.2 1 0 0 1 1 1 1 Amidinotransferase WD40 PF00400.30 NM_001163673.1_3 - 8.8e-13 48.4 7.7 4.9e-06 27.1 0.0 7.3 8 0 0 8 8 8 3 WD domain, G-beta repeat PQQ_2 PF13360.4 NM_001163673.1_3 - 0.082 12.3 0.0 0.2 11.1 0.0 1.4 1 1 0 1 1 1 0 PQQ-like domain ANAPC4_WD40 PF12894.5 NM_001163673.1_3 - 0.13 12.4 0.0 2.2 8.5 0.0 3.0 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Fox-1_C PF12414.6 NM_001142334.1_2 - 3e-41 139.5 21.1 6.5e-41 138.4 21.1 1.6 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 NM_001142334.1_2 - 8.8e-18 63.8 0.1 1.7e-17 62.9 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pribosyltran_N PF13793.4 NM_002765.4_3 - 4.3e-46 155.5 0.3 8.7e-46 154.5 0.1 1.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.4 NM_002765.4_3 - 5.3e-43 147.1 3.5 2.9e-36 125.1 1.5 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.25 NM_002765.4_3 - 4.3e-14 52.2 0.9 1.1e-13 50.8 0.3 1.9 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.4 NM_002765.4_3 - 0.00097 18.5 0.4 0.002 17.5 0.2 1.5 2 0 0 2 2 2 1 Uracil phosphoribosyltransferase V-set PF07686.15 NM_018643.4_1 - 6e-09 35.9 0.0 1.4e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain BATS PF06968.11 NM_018643.4_1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Biotin and Thiamin Synthesis associated domain Asp-B-Hydro_N PF05279.9 NM_001251987.1_1 - 1.7e-12 47.8 20.5 1.7e-12 47.8 20.5 2.4 2 0 0 2 2 2 1 Aspartyl beta-hydroxylase N-terminal region Sec23_helical PF04815.13 NM_001320048.1_1 - 0.052 13.2 0.3 0.095 12.4 0.3 1.3 1 0 0 1 1 1 0 Sec23/Sec24 helical domain DUF4487 PF14868.4 NM_001320048.1_3 - 9.7e-202 671.4 32.9 9.7e-202 671.4 32.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4487) Lectin_C PF00059.19 NM_006438.4_2 - 1.9e-14 54.2 0.0 2.8e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 NM_006438.4_2 - 6.2e-13 48.2 45.3 1.8e-08 33.9 18.2 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) TSP_1 PF00090.17 NM_001145252.1_1 - 4.9e-57 189.8 104.2 2.6e-16 59.4 15.3 7.1 8 0 0 8 8 8 6 Thrombospondin type 1 domain Endosulfine PF04667.15 NM_001306196.1_1 - 8.9e-09 35.2 1.4 1.4e-08 34.6 1.4 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Spectrin PF00435.19 NM_004012.3_3 - 3.2e-109 358.5 204.0 1.4e-13 51.1 7.3 18.1 14 3 2 17 17 17 13 Spectrin repeat EF-hand_2 PF09068.9 NM_004012.3_3 - 4.3e-40 136.5 1.3 4.3e-40 136.5 1.3 3.5 3 0 0 3 3 3 1 EF hand EF-hand_3 PF09069.9 NM_004012.3_3 - 2.2e-39 133.6 0.8 1.1e-38 131.4 0.0 2.8 3 0 0 3 3 3 1 EF-hand ZZ PF00569.15 NM_004012.3_3 - 5.6e-19 67.5 4.2 1.1e-18 66.6 4.2 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type WW PF00397.24 NM_004012.3_3 - 5e-09 35.8 2.1 1.5e-08 34.3 2.1 1.9 1 0 0 1 1 1 1 WW domain Spc7 PF08317.9 NM_004012.3_3 - 0.0016 17.2 2.1 0.0016 17.2 2.1 13.1 4 3 6 12 12 12 2 Spc7 kinetochore protein Apolipoprotein PF01442.16 NM_004012.3_3 - 0.002 17.9 11.4 0.002 17.9 11.4 8.8 8 3 0 9 9 9 2 Apolipoprotein A1/A4/E domain Sec3_C_2 PF15278.4 NM_004012.3_3 - 0.26 11.5 2.7 3 8.1 0.2 3.8 2 0 0 2 2 2 0 Sec3 exocyst complex subunit BPS PF08947.8 NM_001001550.2_1 - 1.9e-28 97.8 0.7 3.7e-28 96.9 0.7 1.5 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 NM_001001550.2_1 - 2.1e-13 50.0 0.0 3.9e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 NM_001001550.2_1 - 2.1e-10 41.0 0.2 4.6e-10 39.9 0.2 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 NM_001001550.2_1 - 4.5e-09 36.6 0.9 6.7e-09 36.1 0.1 1.8 2 0 0 2 2 2 1 PH domain TMEM214 PF10151.7 NM_001083590.1_3 - 1.9e-220 733.6 4.6 5.3e-176 586.8 1.8 2.0 1 1 1 2 2 2 2 TMEM214, C-terminal, caspase 4 activator JUPITER PF17054.3 NM_001002033.2_1 - 2.7e-05 23.7 0.0 4.7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Microtubule-Associated protein Jupiter Aldolase_II PF00596.19 NM_001185055.1_3 - 2.6e-37 128.4 0.0 3.9e-37 127.9 0.0 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Mac PF12464.6 NM_001185055.1_3 - 0.036 14.2 0.2 0.086 13.0 0.2 1.6 1 0 0 1 1 1 0 Maltose acetyltransferase Pkinase_Tyr PF07714.15 NM_001251902.1_2 - 1.5e-72 243.9 0.0 2e-72 243.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001251902.1_2 - 2.3e-30 105.7 0.0 3.6e-30 105.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH3_9 PF14604.4 NM_001251902.1_2 - 0.025 14.3 0.0 0.052 13.3 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain HOIP-UBA PF16678.3 NM_001251902.1_2 - 0.21 11.4 0.0 0.34 10.8 0.0 1.2 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase Methyltransf_23 PF13489.4 NM_001258388.1_1 - 0.0022 17.8 0.0 0.0037 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_001258388.1_1 - 0.084 13.5 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Ras PF00071.20 NM_001142625.2_2 - 7.2e-39 132.8 0.1 9.6e-39 132.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001142625.2_2 - 2.9e-29 101.6 0.0 3.9e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001142625.2_2 - 2.9e-13 49.5 0.0 4.4e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001142625.2_2 - 1.9e-06 27.8 0.0 3.4e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_001142625.2_2 - 0.0039 16.5 0.0 0.0049 16.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 NM_001142625.2_2 - 0.012 14.9 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.9 NM_001142625.2_2 - 0.071 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Dynamin_N PF00350.21 NM_001142625.2_2 - 0.16 11.9 0.0 2.2 8.2 0.0 2.2 2 1 0 2 2 2 0 Dynamin family Flavodoxin_2 PF02525.15 NM_001286137.1_2 - 1.6e-17 63.8 0.1 3.2e-15 56.2 0.1 2.1 1 1 1 2 2 2 2 Flavodoxin-like fold DUF2781 PF10914.6 NM_023003.3_2 - 3.8e-19 69.4 4.0 3.8e-19 69.4 4.0 2.9 3 1 0 3 3 3 1 Protein of unknown function (DUF2781) OAS1_C PF10421.7 NM_003733.3_2 - 9.5e-78 259.8 0.2 1.6e-77 259.1 0.2 1.3 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus ubiquitin PF00240.21 NM_003733.3_2 - 2.5e-19 68.6 0.0 2e-16 59.3 0.0 2.6 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.6 NM_003733.3_2 - 5.9e-08 32.3 0.0 1.4e-06 27.9 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like SCAN PF02023.15 NM_003733.3_2 - 0.012 15.3 1.1 0.07 12.8 0.4 2.5 3 0 0 3 3 3 0 SCAN domain PAH PF02671.19 NM_003733.3_2 - 0.1 12.6 0.1 0.25 11.4 0.1 1.6 1 0 0 1 1 1 0 Paired amphipathic helix repeat Neur_chan_memb PF02932.14 NM_001307945.1_2 - 4.7e-07 30.0 0.2 7.9e-07 29.2 0.2 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 NM_001307945.1_3 - 3.1e-35 121.4 0.6 4.7e-35 120.9 0.6 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Sushi PF00084.18 NM_001017364.1_3 - 1.4e-23 83.2 13.6 6.7e-10 39.3 2.0 3.4 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) IKKbetaNEMObind PF12179.6 NM_001017364.1_3 - 0.22 11.4 2.7 0.49 10.3 2.7 1.5 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain ADH_zinc_N PF00107.24 NM_006373.3_1 - 7.1e-20 71.1 0.1 1.3e-19 70.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 NM_006373.3_1 - 2.5e-19 70.5 0.0 4.5e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 NM_006373.3_1 - 1.3e-08 34.6 0.0 3.2e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Amidohydro_1 PF01979.18 NM_001197294.1_1 - 1e-37 130.1 0.1 1.3e-37 129.8 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 NM_001197294.1_1 - 3.3e-13 49.8 0.1 3.1e-06 26.8 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Methyltransf_PK PF05891.10 NM_001286801.1_1 - 9e-30 103.7 0.0 1.2e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_PK PF05891.10 NM_001286801.1_2 - 2.4e-38 131.7 0.0 3.3e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.4 NM_001286801.1_2 - 0.0083 16.7 0.0 0.014 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_001286801.1_2 - 0.14 12.8 0.0 0.23 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Chlam_OMP PF01308.15 NM_001286801.1_3 - 0.17 10.5 0.2 0.28 9.8 0.2 1.3 1 0 0 1 1 1 0 Chlamydia major outer membrane protein Histone PF00125.22 NM_005692.4_2 - 2.5e-11 44.0 0.0 4.4e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_005692.4_2 - 0.0072 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ABC_tran PF00005.25 NM_005692.4_3 - 1.6e-47 161.3 0.0 5e-25 88.5 0.0 2.9 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.5 NM_005692.4_3 - 1.9e-21 75.7 3.8 1.9e-21 75.7 3.8 3.5 5 0 0 5 5 3 1 ABC transporter AAA_21 PF13304.4 NM_005692.4_3 - 2.3e-15 57.1 2.0 0.00023 20.9 0.0 4.2 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 NM_005692.4_3 - 2.8e-06 26.8 0.3 0.0027 17.3 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.17 NM_005692.4_3 - 4.8e-06 26.0 1.1 0.69 9.2 0.0 3.7 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.14 NM_005692.4_3 - 0.00012 21.9 0.0 0.022 14.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 NM_005692.4_3 - 0.00019 21.4 0.0 0.024 14.6 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.4 NM_005692.4_3 - 0.0004 20.4 0.1 0.16 12.0 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.4 NM_005692.4_3 - 0.0007 19.2 0.7 0.92 9.1 0.0 3.7 3 1 1 4 4 4 1 AAA domain AAA_16 PF13191.4 NM_005692.4_3 - 0.0015 18.8 0.0 0.34 11.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 NM_005692.4_3 - 0.0024 18.0 0.0 0.43 10.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.10 NM_005692.4_3 - 0.0084 15.9 0.9 1.4 8.7 0.0 2.8 3 0 0 3 3 3 1 NACHT domain AAA_28 PF13521.4 NM_005692.4_3 - 0.011 15.9 0.0 0.64 10.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.4 NM_005692.4_3 - 0.011 16.2 0.1 0.47 10.8 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_14 PF13173.4 NM_005692.4_3 - 0.011 15.6 0.0 1.1 9.2 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_15 PF13175.4 NM_005692.4_3 - 0.012 15.2 7.3 0.025 14.1 0.1 3.0 4 0 0 4 4 4 0 AAA ATPase domain AAA_27 PF13514.4 NM_005692.4_3 - 0.017 14.6 1.3 1.3 8.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.4 NM_005692.4_3 - 0.022 15.1 0.0 0.022 15.1 0.0 3.8 4 1 0 4 4 2 0 AAA domain AAA PF00004.27 NM_005692.4_3 - 0.033 14.5 0.4 2.8 8.2 0.2 3.0 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.20 NM_005692.4_3 - 0.093 13.0 0.0 0.93 9.8 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_5 PF07728.12 NM_005692.4_3 - 0.094 12.6 0.1 8 6.3 0.2 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ArgK PF03308.14 NM_005692.4_3 - 0.098 11.5 2.8 4.1 6.2 0.0 2.8 3 0 0 3 3 3 0 ArgK protein Dynamin_N PF00350.21 NM_005692.4_3 - 0.11 12.5 0.4 0.41 10.6 0.0 2.3 3 0 0 3 3 2 0 Dynamin family MukB PF04310.10 NM_005692.4_3 - 0.18 11.5 0.7 1.5 8.5 0.0 2.5 3 0 0 3 3 2 0 MukB N-terminal Rop PF01815.14 NM_005692.4_3 - 0.21 11.4 6.6 0.21 11.3 0.1 2.9 2 1 1 3 3 3 0 Rop protein VWA PF00092.26 NM_002381.4_1 - 3.8e-46 157.4 0.2 5.1e-46 157.0 0.2 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FXa_inhibition PF14670.4 NM_002381.4_1 - 1.5e-33 114.6 66.1 9.1e-10 38.5 10.9 4.8 4 0 0 4 4 4 4 Coagulation Factor Xa inhibitory site VWA_2 PF13519.4 NM_002381.4_1 - 3.7e-16 59.6 0.1 7.3e-16 58.6 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain cEGF PF12662.5 NM_002381.4_1 - 3.8e-15 55.4 47.4 5.7e-05 22.8 3.6 5.1 5 0 0 5 5 5 4 Complement Clr-like EGF-like Matrilin_ccoil PF10393.7 NM_002381.4_1 - 8.4e-15 54.2 0.1 2.4e-14 52.8 0.1 1.9 1 0 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin EGF_CA PF07645.13 NM_002381.4_1 - 1.3e-13 50.7 54.4 9.6e-05 22.4 8.3 4.5 4 0 0 4 4 4 4 Calcium-binding EGF domain EGF PF00008.25 NM_002381.4_1 - 6.5e-08 32.6 65.0 0.0028 17.8 7.4 4.9 5 0 0 5 5 5 4 EGF-like domain Lyase_catalyt PF09093.9 NM_002381.4_1 - 1.2 8.0 3.1 11 5.0 0.5 2.3 1 1 1 2 2 2 0 Lyase, catalytic 7tm_4 PF13853.4 NM_001001923.1_1 - 2.4e-43 148.8 6.5 3.1e-43 148.4 6.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001001923.1_1 - 1.1e-17 64.0 7.1 1.6e-17 63.5 7.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-NF-X1 PF01422.15 NM_152995.5_2 - 8.5e-12 44.8 129.0 1.2e-05 25.2 13.4 17.4 18 1 0 18 18 18 11 NF-X1 type zinc finger CCDC-167 PF15188.4 NM_152995.5_2 - 0.84 9.9 5.9 1.8 8.8 5.9 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 RabGAP-TBC PF00566.16 NM_005665.5_2 - 3.8e-53 180.2 3.3 1.2e-52 178.6 3.3 1.9 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1129 PF06570.9 NM_005665.5_2 - 0.0055 16.1 0.3 0.015 14.7 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) HlyIII PF03006.18 NM_024551.2_3 - 1.2e-70 237.6 21.6 1.7e-70 237.1 21.6 1.2 1 0 0 1 1 1 1 Haemolysin-III related DUF2367 PF10164.7 NM_015379.4_1 - 1.8e-33 115.0 4.3 3.2e-33 114.2 4.3 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2367) MBT PF02820.16 NM_017643.2_3 - 2.2e-89 293.7 2.7 1.1e-27 96.0 0.1 5.1 5 0 0 5 5 5 4 mbt repeat IL17_R_N PF15037.4 NM_153483.2_2 - 1.7e-140 468.4 3.0 7.9e-139 462.9 3.0 2.1 1 1 0 1 1 1 1 Interleukin-17 receptor extracellular region SEFIR PF08357.9 NM_153483.2_2 - 2.2e-22 79.8 0.0 1.3e-14 54.6 0.0 2.3 2 0 0 2 2 2 2 SEFIR domain Antimicrobial10 PF08105.9 NM_153483.2_2 - 1.9 8.5 6.2 0.69 9.9 0.9 2.9 2 0 0 2 2 2 0 Metchnikowin family Myotub-related PF06602.12 NM_017762.2_3 - 7.2e-71 238.8 2.8 1.5e-57 195.0 1.9 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain 3-PAP PF12578.6 NM_017762.2_3 - 3.3e-56 188.5 0.1 5.3e-56 187.9 0.1 1.3 1 0 0 1 1 1 1 Myotubularin-associated protein TPR_2 PF07719.15 NM_001288951.1_3 - 7.1e-18 63.1 11.0 0.00017 21.3 0.0 9.7 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001288951.1_3 - 2.1e-14 52.5 7.5 0.00053 19.6 0.0 8.2 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001288951.1_3 - 1.2e-13 50.0 11.8 0.002 18.1 0.0 9.0 11 0 0 11 11 10 3 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001288951.1_3 - 3e-13 49.1 1.9 0.0012 18.4 0.0 5.4 7 0 0 7 7 7 3 TPR repeat TPR_17 PF13431.4 NM_001288951.1_3 - 5.7e-10 38.8 0.0 1.2 9.5 0.0 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001288951.1_3 - 8.4e-10 38.5 27.3 0.12 13.1 0.1 10.0 5 2 5 10 10 9 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001288951.1_3 - 9.5e-10 38.5 18.5 0.0014 18.7 0.0 7.0 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001288951.1_3 - 5.2e-09 36.5 22.6 0.022 15.3 0.0 6.4 5 1 0 6 6 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001288951.1_3 - 1.9e-08 34.5 18.5 0.023 15.1 0.0 7.3 7 2 1 9 9 8 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001288951.1_3 - 3.9e-07 30.0 10.6 0.31 11.1 4.2 5.2 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.4 NM_001288951.1_3 - 1.1e-05 24.6 4.1 0.0046 16.1 0.2 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001288951.1_3 - 7.4e-05 23.0 7.8 1.8 9.3 0.0 7.5 8 0 0 8 8 7 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001288951.1_3 - 0.00011 22.2 14.1 0.25 11.4 1.4 5.3 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.6 NM_001288951.1_3 - 0.00041 19.2 0.2 0.46 9.2 0.0 2.3 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_7 PF13176.4 NM_001288951.1_3 - 0.00063 19.5 3.3 2 8.5 0.0 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat DUF3808 PF10300.7 NM_001288951.1_3 - 0.0031 16.2 0.1 0.0066 15.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) ChAPs PF09295.8 NM_001288951.1_3 - 0.071 12.0 5.5 1.3 7.8 1.9 2.8 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.4 NM_001288951.1_3 - 0.16 12.2 18.0 0.14 12.4 1.3 4.8 5 1 1 6 6 4 0 Tetratricopeptide repeat MIT PF04212.16 NM_001288951.1_3 - 0.44 10.5 7.2 5.6 7.0 0.1 3.9 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain FNIP_M PF14637.4 NM_133372.2_2 - 2.3e-88 295.9 0.0 4.1e-88 295.0 0.0 1.4 1 0 0 1 1 1 1 Folliculin-interacting protein middle domain FNIP_C PF14638.4 NM_133372.2_2 - 5.1e-70 234.9 0.1 8.6e-70 234.1 0.1 1.4 1 0 0 1 1 1 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.4 NM_133372.2_2 - 9.9e-25 88.0 1.8 9.9e-25 88.0 1.8 2.7 2 1 0 2 2 2 1 Folliculin-interacting protein N-terminus RGM_C PF06534.11 NM_001166289.1_2 - 3.7e-71 238.0 0.0 4.9e-71 237.6 0.0 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus RGM_N PF06535.10 NM_001166289.1_2 - 3.3e-70 235.5 1.0 5.1e-70 234.8 1.0 1.3 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus Borealin PF10512.7 NM_018101.3_2 - 2e-30 105.1 0.0 4.9e-30 103.8 0.0 1.7 1 0 0 1 1 1 1 Cell division cycle-associated protein 8 Nbl1_Borealin_N PF10444.7 NM_018101.3_2 - 5.7e-21 73.8 1.5 1.9e-19 68.9 1.2 2.3 2 0 0 2 2 2 1 Nbl1 / Borealin N terminal SWIRM-assoc_1 PF16495.3 NM_018101.3_2 - 6.6 6.8 9.2 2.9 7.9 2.8 2.2 2 0 0 2 2 2 0 SWIRM-associated region 1 Pkinase PF00069.23 NM_003565.2_2 - 5.6e-69 232.3 0.0 8.2e-69 231.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_003565.2_2 - 1.1e-50 172.2 0.0 1.7e-50 171.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.6 NM_003565.2_2 - 1.1e-22 80.5 0.5 1.8e-22 79.8 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Kdo PF06293.12 NM_003565.2_2 - 5.9e-06 25.6 0.0 1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 NM_003565.2_2 - 8.4e-05 22.1 0.1 0.00014 21.4 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.4 NM_003565.2_2 - 0.028 13.6 0.0 0.14 11.3 0.0 2.1 2 1 0 2 2 2 0 Kinase-like APH PF01636.21 NM_003565.2_2 - 0.028 14.2 0.0 0.078 12.8 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family PK PF00224.19 NM_001206799.1_1 - 9e-172 570.6 2.0 1.1e-171 570.3 2.0 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 NM_001206799.1_1 - 7.5e-34 116.3 0.0 1.9e-33 115.1 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 NM_001206799.1_1 - 0.0012 17.9 0.4 0.0059 15.6 0.1 2.1 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Guanylate_cyc PF00211.18 NM_001281768.1_2 - 1.2e-61 207.4 0.1 1.8e-61 206.8 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.3 NM_001281768.1_2 - 2.9e-28 99.0 0.0 4.3e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Adenylyl cyclase N-terminal extracellular and transmembrane region HNOBA PF07701.12 NM_001281768.1_2 - 0.7 9.2 4.8 0.2 11.0 0.2 2.0 2 0 0 2 2 2 0 Heme NO binding associated OAD_gamma PF04277.11 NM_001281768.1_2 - 2.8 8.4 6.7 5.7 7.5 6.7 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain ETRAMP PF09716.8 NM_001281768.1_2 - 5.3 7.0 12.1 0.22 11.4 4.8 2.4 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DNA_pol_A PF00476.18 NM_181808.3_2 - 4.1e-122 407.7 0.2 6.6e-122 407.0 0.2 1.3 1 0 0 1 1 1 1 DNA polymerase family A zf-H2C2_2 PF13465.4 NM_001143939.1_2 - 1.2e-112 363.6 117.6 1.2e-08 34.9 2.3 18.0 18 0 0 18 18 18 15 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001143939.1_2 - 1.2e-84 274.2 130.9 3e-07 30.4 1.2 17.3 17 0 0 17 17 17 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001143939.1_2 - 1.7e-45 149.6 122.6 0.00054 20.4 0.8 17.1 17 0 0 17 17 17 16 C2H2-type zinc finger KRAB PF01352.25 NM_001143939.1_2 - 3.1e-25 87.4 0.1 5.6e-25 86.6 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001143939.1_2 - 2.9e-17 62.0 117.2 0.022 14.6 1.0 18.5 16 4 0 16 16 16 12 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001143939.1_2 - 1.6e-15 56.8 81.4 0.016 15.2 1.2 13.8 6 4 10 16 16 16 11 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001143939.1_2 - 1.2e-09 38.1 81.8 0.52 10.5 0.2 16.2 16 0 0 16 16 16 7 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_001143939.1_2 - 2.4e-09 36.7 86.5 0.032 13.9 0.1 15.1 15 0 0 15 15 15 7 zinc-finger C2H2-type FAM178 PF14816.4 NM_001143939.1_2 - 1.3e-08 34.1 10.3 2.5 6.8 0.0 9.3 3 2 7 11 11 11 1 Family of unknown function, FAM178 zinc_ribbon_15 PF17032.3 NM_001143939.1_2 - 3.4e-08 34.0 65.8 0.1 13.3 1.5 8.6 1 1 7 9 9 9 6 zinc-ribbon family DZR PF12773.5 NM_001143939.1_2 - 5.3e-06 26.2 60.3 4.2 7.4 0.1 8.8 2 1 0 2 2 1 1 Double zinc ribbon XPA_N PF01286.16 NM_001143939.1_2 - 0.00014 21.7 54.9 22 5.1 0.9 14.8 16 0 0 16 16 16 0 XPA protein N-terminal TFIIS_C PF01096.16 NM_001143939.1_2 - 0.0004 20.1 67.2 4.6 7.0 0.5 14.4 14 0 0 14 14 14 2 Transcription factor S-II (TFIIS) zf-LYAR PF08790.9 NM_001143939.1_2 - 0.00082 19.1 73.1 0.21 11.4 1.4 15.5 16 0 0 16 16 16 2 LYAR-type C2HC zinc finger MRP-S23 PF10484.7 NM_001143939.1_2 - 0.0018 18.4 0.0 75 3.4 0.0 6.6 5 4 6 11 11 10 0 Mitochondrial ribosomal protein S23 BolA PF01722.16 NM_001143939.1_2 - 0.012 15.8 33.8 0.5 10.5 0.6 7.8 3 2 4 8 8 8 0 BolA-like protein Arc_trans_TRASH PF08394.8 NM_001143939.1_2 - 0.092 13.0 33.2 11 6.3 0.0 11.0 12 3 1 13 13 13 0 Archaeal TRASH domain Bac_DnaA_C PF08299.9 NM_001143939.1_3 - 0.012 15.5 5.3 8.7 6.3 0.0 5.7 3 2 6 9 9 9 0 Bacterial dnaA protein helix-turn-helix Baculo_LEF-11 PF06385.10 NM_001143939.1_3 - 0.069 13.5 8.7 2.2 8.7 0.8 4.1 4 0 0 4 4 4 0 Baculovirus LEF-11 protein Consortin_C PF15281.4 NM_152609.2_1 - 2.8e-53 178.6 0.0 4.8e-53 177.8 0.0 1.4 1 0 0 1 1 1 1 Consortin C-terminus Abhydrolase_2 PF02230.14 NM_001300770.1_1 - 1.2e-33 116.7 0.3 8e-32 110.7 0.3 2.1 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.16 NM_001300770.1_1 - 2.5e-06 27.1 0.0 3.5e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.6 NM_001300770.1_1 - 3.4e-06 26.4 0.5 0.0018 17.5 0.0 2.3 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.11 NM_001300770.1_1 - 4.8e-06 26.4 0.0 0.0015 18.3 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.5 NM_001300770.1_1 - 2.9e-05 23.7 0.0 4.4e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.18 NM_001300770.1_1 - 0.00032 20.3 0.0 0.00047 19.7 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.19 NM_001300770.1_1 - 0.0025 17.2 0.4 0.23 10.8 0.0 2.2 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.18 NM_001300770.1_1 - 0.0046 16.5 0.4 0.026 14.0 0.4 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_001300770.1_1 - 0.012 16.1 0.0 0.017 15.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family FSH1 PF03959.11 NM_001300770.1_1 - 0.02 14.4 0.1 3.3 7.2 0.0 2.1 1 1 0 2 2 2 0 Serine hydrolase (FSH1) Lipase_3 PF01764.23 NM_001300770.1_1 - 0.1 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Tmemb_185A PF10269.7 NM_032508.3_3 - 5.4e-61 206.3 29.0 8.3e-61 205.7 29.0 1.3 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein TT_ORF2 PF02957.13 NM_032508.3_3 - 1.1 10.1 2.9 2.3 9.0 2.9 1.4 1 0 0 1 1 1 0 TT viral ORF2 AMP-binding PF00501.26 NM_001308169.1_3 - 1.7e-65 221.2 0.0 2.2e-65 220.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 NM_001308169.1_3 - 3.1e-22 79.2 0.8 5.4e-22 78.4 0.8 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain zf-H2C2_2 PF13465.4 NM_019591.3_2 - 4.9e-87 282.6 79.3 3.4e-08 33.5 0.3 14.2 15 0 0 15 15 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_019591.3_2 - 2.1e-64 210.4 86.9 8.5e-06 25.8 0.8 13.9 14 0 0 14 14 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_019591.3_2 - 2.6e-37 124.1 92.5 0.0046 17.5 1.8 14.2 14 0 0 14 14 14 13 C2H2-type zinc finger KRAB PF01352.25 NM_019591.3_2 - 1.8e-19 69.0 0.2 3.6e-19 68.0 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_019591.3_2 - 4.1e-13 48.8 83.1 0.17 11.8 0.3 13.8 13 0 0 13 13 13 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_019591.3_2 - 1.4e-05 25.0 63.0 0.026 14.5 0.6 8.3 4 2 6 10 10 10 5 Zinc ribbon domain C1_4 PF07975.10 NM_019591.3_2 - 1.5e-05 25.0 50.2 0.19 11.9 2.0 9.0 3 2 7 10 10 10 4 TFIIH C1-like domain CpXC PF14353.4 NM_019591.3_2 - 0.022 14.7 45.3 0.87 9.5 0.1 11.1 2 2 7 11 11 11 0 CpXC protein zinc_ribbon_15 PF17032.3 NM_019591.3_2 - 0.029 15.0 51.7 1 10.0 0.3 7.2 1 1 6 7 7 7 0 zinc-ribbon family MBD PF01429.17 NM_019591.3_2 - 0.095 12.3 1.6 45 3.7 0.0 4.4 4 1 0 4 4 4 0 Methyl-CpG binding domain DUF4934 PF16288.3 NM_019591.3_2 - 0.16 11.8 4.0 40 4.1 0.0 4.8 1 1 4 6 6 6 0 Domain of unknown function (DUF4934) DUF899 PF05988.10 NM_019591.3_2 - 0.39 10.1 10.6 21 4.4 0.1 4.8 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF899) BolA PF01722.16 NM_019591.3_2 - 3 8.1 6.0 18 5.5 0.3 3.3 3 0 0 3 3 3 0 BolA-like protein PGC7_Stella PF15549.4 NM_001321180.1_2 - 1.6e-74 249.2 1.8 1.6e-74 249.2 1.8 2.1 1 1 1 2 2 2 2 PGC7/Stella/Dppa3 domain Herpes_UL92 PF03048.12 NM_001321180.1_2 - 1.2 8.8 6.8 1.8 8.2 6.8 1.2 1 0 0 1 1 1 0 UL92 family S_100 PF01023.17 NM_001014342.2_2 - 2.7e-15 55.7 0.1 6.2e-15 54.5 0.1 1.7 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 NM_001014342.2_2 - 0.00012 22.4 0.3 0.00023 21.4 0.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_001014342.2_2 - 0.033 13.6 2.0 0.035 13.5 0.5 1.8 2 0 0 2 2 2 0 EF hand Uricase PF01014.16 NM_001014342.2_3 - 0.031 14.6 8.0 30 4.9 0.0 7.7 9 0 0 9 9 9 0 Uricase ULD PF16534.3 NM_001014342.2_3 - 1.9 8.5 9.7 21 5.2 0.1 5.3 4 1 2 6 6 6 0 Ubiquitin-like oligomerisation domain of SATB Forkhead PF00250.16 NM_004496.3_2 - 7.7e-37 125.4 0.3 1.4e-36 124.5 0.3 1.4 1 0 0 1 1 1 1 Forkhead domain Forkhead_N PF08430.10 NM_004496.3_2 - 1.2e-28 100.3 38.1 1.2e-28 100.3 38.1 2.4 2 1 1 3 3 3 1 Forkhead N-terminal region HNF_C PF09354.8 NM_004496.3_2 - 9.1e-28 97.0 3.0 9.1e-28 97.0 3.0 3.2 2 0 0 2 2 2 1 HNF3 C-terminal domain Shisa PF13908.4 NM_001145204.2_2 - 4.6e-51 173.6 0.3 4.6e-51 173.6 0.3 2.3 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator zf-H2C2_2 PF13465.4 NM_018008.3_2 - 1.6e-29 100.8 45.4 5.7e-06 26.4 0.2 7.7 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_018008.3_2 - 1.2e-22 78.9 66.0 6.8e-06 26.1 2.1 7.0 7 0 0 7 7 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_018008.3_2 - 3.7e-15 55.2 56.9 0.0044 17.6 0.7 7.0 7 0 0 7 7 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_018008.3_2 - 9.8e-05 22.4 38.9 0.5 10.6 1.4 6.5 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_018008.3_2 - 0.00011 22.0 38.6 0.019 14.8 2.7 6.5 6 0 0 6 6 6 4 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 NM_018008.3_2 - 0.17 12.5 17.6 1.7 9.3 2.1 3.4 1 1 2 3 3 3 0 zinc-ribbon family Zn-ribbon_8 PF09723.8 NM_018008.3_2 - 0.3 11.1 26.9 0.92 9.6 2.1 5.2 4 1 1 5 5 5 0 Zinc ribbon domain zf-Di19 PF05605.10 NM_018008.3_2 - 0.72 10.1 31.2 0.17 12.1 6.0 4.4 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.9 NM_018008.3_2 - 0.72 9.6 7.7 20 4.9 0.0 3.8 2 1 2 4 4 4 0 GAGA factor zf-Sec23_Sec24 PF04810.13 NM_018008.3_2 - 5.3 7.0 23.9 0.81 9.7 2.7 5.3 3 3 2 5 5 5 0 Sec23/Sec24 zinc finger zf-AN1 PF01428.14 NM_018008.3_2 - 5.6 7.1 32.8 0.67 10.0 1.9 6.3 5 1 1 6 6 6 0 AN1-like Zinc finger zf-C2H2_9 PF16293.3 NM_018008.3_2 - 6.5 6.6 9.1 61 3.4 0.1 4.2 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) RUN PF02759.17 NM_001291993.1_2 - 2e-32 111.8 0.2 5.9e-32 110.3 0.0 1.9 2 0 0 2 2 2 1 RUN domain FYVE PF01363.19 NM_001291993.1_2 - 3.2e-05 23.8 6.3 7e-05 22.7 6.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger Trimer_CC PF08954.9 NM_001291993.1_2 - 0.00014 21.3 4.9 0.12 11.8 0.0 2.7 2 0 0 2 2 2 2 Trimerisation motif Reo_sigmaC PF04582.10 NM_001291993.1_2 - 0.052 12.8 11.1 0.41 9.9 3.3 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DZR PF12773.5 NM_001291993.1_2 - 0.28 11.1 9.5 0.69 9.8 1.8 2.6 1 1 1 2 2 2 0 Double zinc ribbon PAXX PF15384.4 NM_001291993.1_2 - 0.38 10.3 6.7 0.69 9.4 6.7 1.3 1 0 0 1 1 1 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Baculo_PEP_C PF04513.10 NM_001291993.1_2 - 7.2 6.5 14.5 1.9 8.4 2.5 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.4 NM_001291993.1_2 - 9.4 5.4 29.7 2 7.5 10.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) HSP90 PF00183.16 NM_003299.2_3 - 7.5e-230 764.0 27.5 7.5e-230 764.0 27.5 1.7 1 1 1 2 2 2 1 Hsp90 protein HATPase_c PF02518.24 NM_003299.2_3 - 1.2e-13 51.4 0.4 2.1e-13 50.7 0.4 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 NM_003299.2_3 - 5e-11 42.4 0.4 1.2e-10 41.2 0.4 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4518 PF15008.4 NM_003299.2_3 - 0.046 12.7 4.0 0.96 8.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) DUF913 PF06025.10 NM_003299.2_3 - 3.9 6.2 9.2 3.3 6.4 0.7 2.8 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) zf-HC5HC2H_2 PF13832.4 NM_001287443.1_2 - 4.2e-32 110.4 2.6 4.2e-32 110.4 2.6 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 NM_001287443.1_2 - 1.1e-27 95.9 2.0 1.1e-27 95.9 2.0 3.6 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.4 NM_001287443.1_2 - 1.5e-12 46.7 6.4 1.5e-12 46.7 6.4 3.4 3 0 0 3 3 3 1 PHD-finger PHD PF00628.27 NM_001287443.1_2 - 1.6e-11 43.8 20.9 8.9e-10 38.2 9.4 3.3 3 0 0 3 3 3 2 PHD-finger EPL1 PF10513.7 NM_001287443.1_2 - 9.4e-07 29.2 0.2 9.4e-07 29.2 0.2 2.6 2 0 0 2 2 2 1 Enhancer of polycomb-like C1_1 PF00130.20 NM_001287443.1_2 - 0.0034 17.1 2.9 0.0034 17.1 2.9 3.2 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.14 NM_001287443.1_2 - 0.074 13.2 19.5 0.3 11.3 4.8 3.7 3 0 0 3 3 3 0 C1 domain Prok-RING_1 PF14446.4 NM_001287443.1_2 - 0.27 11.0 14.6 2.2 8.1 7.6 3.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.9 NM_001287443.1_2 - 8.1 6.7 17.0 0.16 12.2 4.0 3.0 2 0 0 2 2 2 0 RING-like domain Ank_2 PF12796.5 NM_033394.2_2 - 1.4e-51 172.9 1.4 3.5e-14 53.0 0.0 6.0 2 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_033394.2_2 - 3.4e-42 142.1 11.7 4.4e-08 33.4 0.0 7.8 2 2 6 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_033394.2_2 - 2.1e-30 101.3 1.9 0.0006 19.9 0.0 9.9 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.4 NM_033394.2_2 - 5.4e-29 99.7 10.5 5e-10 39.3 0.0 7.2 3 1 4 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.28 NM_033394.2_2 - 5e-25 86.7 11.1 0.0011 19.2 0.0 10.4 11 0 0 11 11 10 5 Ankyrin repeat TPR_2 PF07719.15 NM_033394.2_2 - 3.8e-09 35.8 5.4 0.022 14.7 0.5 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_033394.2_2 - 1.6e-05 24.8 0.4 6e-05 23.0 0.2 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_033394.2_2 - 4.6e-05 22.9 2.3 0.83 9.3 0.1 3.6 3 0 0 3 3 3 2 TPR repeat TPR_14 PF13428.4 NM_033394.2_2 - 0.0001 22.7 1.3 0.00054 20.4 1.0 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.26 NM_033394.2_2 - 0.00031 20.3 4.7 0.11 12.3 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_033394.2_2 - 0.00037 20.3 0.3 0.036 14.1 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_033394.2_2 - 0.00038 21.0 0.7 0.23 12.1 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.4 NM_033394.2_2 - 0.0013 18.8 0.6 5.9 7.4 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_033394.2_2 - 0.0021 18.4 4.8 0.011 16.1 0.8 3.4 2 1 2 4 4 4 3 Tetratricopeptide repeat AAA_16 PF13191.4 NM_033394.2_2 - 0.0022 18.3 0.0 0.0091 16.3 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain TPR_12 PF13424.4 NM_033394.2_2 - 0.045 13.9 1.6 0.11 12.7 0.1 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_033394.2_2 - 0.22 11.6 3.9 0.096 12.8 0.9 2.0 2 0 0 2 2 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.4 NM_033394.2_2 - 0.31 10.1 1.8 1 8.3 1.8 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat MAGE_N PF12440.6 NM_002365.4_3 - 2.5e-19 69.6 8.6 2.5e-19 69.6 8.6 1.7 2 0 0 2 2 2 1 Melanoma associated antigen family N terminal MAGE PF01454.17 NM_002365.4_3 - 3.1e-13 49.8 4.3 3.6e-12 46.3 0.0 2.9 2 1 0 2 2 2 1 MAGE family Methyltransf_12 PF08242.10 NM_152396.3_1 - 1.2e-17 64.4 0.1 6.9e-17 61.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_152396.3_1 - 4.9e-13 49.5 0.0 9.2e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 NM_152396.3_1 - 1.2e-12 48.0 0.1 1.8e-12 47.3 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_152396.3_1 - 1e-09 38.8 0.0 1.9e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_152396.3_1 - 1.8e-09 37.4 0.0 2.8e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 NM_152396.3_1 - 0.0018 17.7 0.0 0.003 17.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Fam20C PF06702.10 NM_017565.3_1 - 1.2e-98 329.1 0.0 1.8e-98 328.5 0.0 1.3 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.4 NM_017565.3_1 - 0.0069 15.2 0.0 0.013 14.3 0.0 1.3 1 0 0 1 1 1 1 FAM198 protein An_peroxidase PF03098.13 NM_000250.1_1 - 3.6e-179 596.6 0.0 4.5e-179 596.3 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase EF_assoc_2 PF08356.10 NM_138769.2_1 - 1.7e-32 111.1 0.0 2.8e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 EF hand associated Ras PF00071.20 NM_138769.2_1 - 5.8e-23 81.1 0.0 1.2e-17 63.9 0.0 2.6 2 1 0 2 2 2 2 Ras family EF_assoc_1 PF08355.10 NM_138769.2_1 - 8.1e-23 79.7 0.0 5.9e-22 77.0 0.0 2.2 2 0 0 2 2 2 1 EF hand associated Roc PF08477.11 NM_138769.2_1 - 3.1e-10 40.2 0.0 1.2e-07 31.9 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_138769.2_1 - 4.3e-06 26.2 0.0 9.5e-06 25.0 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family EF-hand_7 PF13499.4 NM_138769.2_1 - 1.5e-05 25.3 0.0 0.071 13.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair MMR_HSR1 PF01926.21 NM_138769.2_1 - 7.2e-05 22.7 0.0 0.066 13.2 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.30 NM_138769.2_1 - 0.00016 20.9 0.0 0.016 14.6 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 NM_138769.2_1 - 0.00017 21.1 0.1 0.0031 17.2 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain AAA_16 PF13191.4 NM_138769.2_1 - 0.00026 21.3 0.2 0.81 9.9 0.0 2.6 3 0 0 3 3 2 2 AAA ATPase domain Dynamin_N PF00350.21 NM_138769.2_1 - 0.0049 16.8 0.1 1.6 8.7 0.0 2.3 2 0 0 2 2 2 1 Dynamin family DUF258 PF03193.14 NM_138769.2_1 - 0.0071 16.1 0.0 21 4.8 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function, DUF258 AAA_22 PF13401.4 NM_138769.2_1 - 0.016 15.3 0.0 6.4 6.9 0.0 2.6 2 1 0 2 2 2 0 AAA domain SRPRB PF09439.8 NM_138769.2_1 - 0.019 14.3 0.0 0.035 13.4 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.4 NM_138769.2_1 - 0.048 13.6 0.0 9.6 6.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.25 NM_138769.2_1 - 0.077 13.4 0.0 8.7 6.7 0.0 2.3 2 0 0 2 2 2 0 ABC transporter SPARC_Ca_bdg PF10591.7 NM_138769.2_1 - 0.096 12.9 0.0 10 6.3 0.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Septin PF00735.16 NM_138769.2_1 - 0.11 11.6 0.0 9.3 5.3 0.0 2.3 2 0 0 2 2 2 0 Septin PduV-EutP PF10662.7 NM_138769.2_1 - 0.13 11.8 0.2 1 9.0 0.1 2.4 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation EF-hand_5 PF13202.4 NM_138769.2_1 - 0.19 11.2 0.0 0.4 10.2 0.0 1.6 1 0 0 1 1 1 0 EF hand Serpin PF00079.18 NM_001012303.2_1 - 9.3e-112 373.9 7.7 1.1e-111 373.6 7.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) TMEM43 PF07787.10 NM_024334.2_3 - 7.1e-83 277.7 0.0 1e-82 277.2 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 43 BEX PF04538.10 NM_001282674.1_3 - 1.1e-18 68.0 8.1 3.1e-18 66.5 8.1 1.6 1 1 0 1 1 1 1 Brain expressed X-linked like family BCL_N PF04714.11 NM_001707.3_2 - 1.4e-27 95.3 6.6 1.4e-27 95.3 6.6 1.8 2 0 0 2 2 2 1 BCL7, N-terminal conserver region Staphylcoagulse PF04022.10 NM_024840.3_1 - 0.29 10.6 1.9 19 4.8 0.1 2.4 2 0 0 2 2 2 0 Staphylocoagulase repeat zf-H2C2_2 PF13465.4 NM_024840.3_3 - 5.1e-83 270.0 79.4 8.3e-09 35.4 0.5 13.8 14 0 0 14 14 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_024840.3_3 - 2.7e-59 194.3 88.4 5.2e-06 26.5 4.3 13.7 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_024840.3_3 - 2.1e-29 99.5 88.0 0.0037 17.8 2.7 13.6 14 0 0 14 14 14 11 C2H2-type zinc finger KRAB PF01352.25 NM_024840.3_3 - 5.6e-25 86.6 0.6 1.1e-24 85.7 0.6 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_024840.3_3 - 1.4e-09 37.5 72.5 0.021 14.6 1.0 12.9 12 2 0 12 12 12 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_024840.3_3 - 4e-09 36.3 47.8 0.023 14.7 0.1 8.3 3 3 6 9 9 9 8 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_024840.3_3 - 0.00016 21.7 55.4 0.65 10.2 0.5 12.0 11 1 1 12 12 12 5 Zinc-finger double-stranded RNA-binding Translat_reg PF01818.15 NM_024840.3_3 - 0.046 13.6 0.0 0.091 12.6 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage translational regulator zf-trcl PF13451.4 NM_024840.3_3 - 0.067 12.9 47.7 4.9 7.0 0.1 10.9 11 1 0 11 11 11 0 Probable zinc-ribbon domain DUF3936 PF13072.4 NM_024840.3_3 - 0.071 12.8 0.0 0.83 9.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3936) XPA_N PF01286.16 NM_024840.3_3 - 0.12 12.3 47.2 8.8 6.3 0.0 11.6 12 0 0 12 12 12 0 XPA protein N-terminal DUF3268 PF11672.6 NM_024840.3_3 - 0.33 11.2 40.0 0.99 9.6 0.9 7.3 2 2 9 11 11 11 0 zinc-finger-containing domain zinc_ribbon_9 PF14369.4 NM_024840.3_3 - 1.2 9.3 39.0 1.2 9.3 0.0 9.2 10 2 2 12 12 12 0 zinc-ribbon ADK_lid PF05191.12 NM_024840.3_3 - 5.9 6.9 34.7 0.96 9.4 0.9 7.0 5 3 1 6 6 6 0 Adenylate kinase, active site lid AMP-binding PF00501.26 NM_174917.4_3 - 6.3e-83 278.6 0.0 8.4e-83 278.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 NM_174917.4_3 - 1.2e-19 70.9 0.1 2.3e-19 70.0 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Lectin_C PF00059.19 NM_001199805.1_2 - 1.6e-18 67.2 2.4 8.7e-17 61.7 1.4 2.6 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 NM_001199805.1_2 - 0.00021 20.8 5.1 0.00066 19.2 5.0 1.6 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 NM_001199805.1_2 - 0.0056 15.9 0.2 0.0094 15.1 0.2 1.3 1 0 0 1 1 1 1 Chordopoxvirus A33R protein Caldesmon PF02029.13 NM_001013255.1_1 - 1e-24 87.1 3.8 1e-24 87.1 3.8 3.0 3 1 0 3 3 3 2 Caldesmon PRKCSH PF07915.11 NM_001261420.1_1 - 1.5e-15 57.8 5.1 1.5e-15 57.8 5.1 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.4 NM_001261420.1_1 - 0.00054 19.5 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Nucleo_P87 PF07267.9 NM_001261420.1_1 - 0.13 11.0 7.2 0.23 10.2 7.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 ATG27 PF09451.8 NM_001261420.1_1 - 0.13 12.0 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 DNA_pol_phi PF04931.11 NM_001261420.1_1 - 0.39 8.7 18.4 0.7 7.8 18.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi Astro_capsid_p PF12226.6 NM_001261420.1_1 - 1.1 8.2 4.9 1.7 7.6 4.9 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein GIT_CC PF16559.3 NM_001321792.1_1 - 0.053 13.4 0.4 0.093 12.7 0.4 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor MAD PF05557.11 NM_001321792.1_1 - 0.27 9.4 6.1 0.35 9.0 6.1 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein Homeobox PF00046.27 NM_153693.4_3 - 2.3e-20 72.0 7.9 4.8e-20 71.0 7.9 1.6 1 0 0 1 1 1 1 Homeobox domain Mab-21 PF03281.12 NM_033397.3_1 - 5.9e-15 55.2 0.2 1.5e-14 53.9 0.2 1.6 1 1 0 1 1 1 1 Mab-21 protein DivIC PF04977.13 NM_033397.3_1 - 0.044 13.4 2.3 0.077 12.6 2.3 1.3 1 0 0 1 1 1 0 Septum formation initiator Transcrip_act PF04949.11 NM_033397.3_1 - 2.5 7.8 7.2 4.3 7.1 7.2 1.2 1 0 0 1 1 1 0 Transcriptional activator Neurexophilin PF06312.10 NM_007224.3_2 - 3.9e-66 222.4 6.1 1.1e-34 119.6 2.6 2.3 2 0 0 2 2 2 2 Neurexophilin FtsJ PF01728.17 NM_018348.5_2 - 1.6e-30 106.3 0.1 2.3e-28 99.3 0.0 2.2 2 0 0 2 2 2 2 FtsJ-like methyltransferase LCCL PF03815.17 NM_031461.5_1 - 4.8e-51 170.7 7.2 3.1e-26 91.2 0.1 2.6 2 0 0 2 2 2 2 LCCL domain CAP PF00188.24 NM_031461.5_1 - 9.3e-20 71.6 2.0 1.5e-19 70.9 2.0 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Rxt3 PF08642.8 NM_031461.5_1 - 0.017 15.7 0.0 0.31 11.7 0.0 2.3 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Nefa_Nip30_N PF10187.7 NM_024946.2_2 - 3.2e-31 107.6 20.9 5.9e-31 106.8 20.9 1.4 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 JAKMIP_CC3 PF16034.3 NM_001323089.1_2 - 7.4e-81 270.8 20.8 7.4e-81 270.8 20.8 5.7 4 2 1 5 5 5 1 JAKMIP CC3 domain DUF1308 PF07000.9 NM_001099858.1_3 - 2.1e-114 382.3 0.3 2.5e-114 382.0 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) SMK-1 PF04802.13 NM_001282850.1_3 - 4.3e-81 271.2 5.9 9.8e-81 270.1 5.9 1.7 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.21 NM_001282850.1_3 - 0.00051 19.8 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 WH1 domain IGF2_C PF08365.9 NM_001282850.1_3 - 0.014 15.3 0.1 0.036 14.0 0.1 1.6 1 0 0 1 1 1 0 Insulin-like growth factor II E-peptide Ran_BP1 PF00638.16 NM_001282850.1_3 - 0.016 15.3 0.8 0.031 14.4 0.0 1.8 2 0 0 2 2 2 0 RanBP1 domain Diphtheria_T PF02764.12 NM_001282850.1_3 - 0.13 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Diphtheria toxin, T domain BLOC1_2 PF10046.7 NM_001282439.1_3 - 2.3e-32 111.0 6.5 3.3e-32 110.5 6.5 1.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 ParB PF08775.8 NM_001282439.1_3 - 0.12 12.7 2.7 0.2 12.0 2.7 1.2 1 0 0 1 1 1 0 ParB family Stathmin PF00836.17 NM_015894.3_2 - 1.3e-53 180.4 21.8 2e-53 179.9 21.8 1.3 1 0 0 1 1 1 1 Stathmin family Exonuc_VII_L PF02601.13 NM_015894.3_2 - 0.034 13.6 3.6 0.049 13.1 3.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.12 NM_015894.3_2 - 6.6 6.6 9.5 11 5.9 9.5 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) EF-hand_7 PF13499.4 NM_173194.2_3 - 5.9e-23 81.0 3.3 1.5e-15 57.2 0.4 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_173194.2_3 - 1.4e-20 71.1 6.0 6.1e-07 28.4 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_173194.2_3 - 2.2e-18 64.5 3.7 2.6e-05 23.7 0.1 3.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.4 NM_173194.2_3 - 2e-16 58.5 2.0 7.3e-05 22.0 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 NM_173194.2_3 - 1.2e-14 53.7 0.4 7.3e-06 25.5 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_173194.2_3 - 8e-05 22.8 2.0 0.011 15.9 0.6 3.3 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_173194.2_3 - 0.0076 16.0 0.7 0.13 12.1 0.1 2.4 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.4 NM_173194.2_3 - 0.09 13.0 0.2 3.8 7.8 0.0 2.6 2 1 0 2 2 2 0 EF-hand domain Caleosin PF05042.11 NM_173194.2_3 - 0.49 10.2 1.8 21 4.8 0.1 3.0 1 1 2 3 3 3 0 Caleosin related protein DER1 PF04511.13 NM_001002862.2_2 - 5.7e-68 228.4 7.1 7.7e-68 228.0 7.1 1.2 1 0 0 1 1 1 1 Der1-like family Oleosin PF01277.15 NM_001002862.2_2 - 0.15 11.7 3.4 0.075 12.6 0.3 2.1 1 1 1 2 2 2 0 Oleosin HIG_1_N PF04588.11 NM_016438.3_3 - 3e-15 56.0 1.0 4.3e-15 55.6 1.0 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Topoisom_I PF01028.18 NM_052963.2_1 - 2.9e-98 327.6 1.8 2.9e-98 327.6 1.8 1.7 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.13 NM_052963.2_1 - 4.3e-98 326.9 0.6 4.3e-98 326.9 0.6 2.0 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.4 NM_052963.2_1 - 5.8e-32 109.3 0.1 1.4e-31 108.0 0.1 1.7 1 0 0 1 1 1 1 C-terminal topoisomerase domain DUF4407 PF14362.4 NM_052963.2_1 - 0.5 9.5 14.4 0.049 12.8 9.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Med9 PF07544.11 NM_052963.2_1 - 0.9 9.5 8.0 1.6 8.8 5.4 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Exonuc_VII_L PF02601.13 NM_052963.2_1 - 1.8 8.0 10.7 2.1 7.7 9.1 1.8 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF349 PF03993.10 NM_052963.2_1 - 1.8 8.8 13.5 2 8.7 6.1 3.2 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) FUSC PF04632.10 NM_052963.2_1 - 6.2 5.1 6.6 10 4.4 6.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family ANTH PF07651.14 NM_001303099.1_2 - 1.1e-77 260.6 3.4 4.1e-77 258.8 0.0 2.1 2 0 0 2 2 2 1 ANTH domain HIP1_clath_bdg PF16515.3 NM_001303099.1_2 - 6.3e-30 103.6 22.1 6.3e-30 103.6 22.1 4.0 3 1 1 4 4 4 2 Clathrin-binding domain of Huntingtin-interacting protein 1 LPP PF04728.11 NM_001303099.1_2 - 2.9 8.2 18.9 5.3 7.4 0.4 4.9 3 2 1 4 4 4 0 Lipoprotein leucine-zipper Cyclin_C_2 PF16899.3 NM_001239.3_3 - 5.8e-27 93.9 0.7 3.4e-25 88.3 0.2 2.6 3 0 0 3 3 3 1 Cyclin C-terminal domain Cyclin_N PF00134.21 NM_001239.3_3 - 7.4e-09 35.3 0.2 1.6e-08 34.3 0.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 NM_001239.3_3 - 0.028 14.4 0.2 0.3 11.1 0.1 2.3 2 0 0 2 2 2 0 Cyclin, C-terminal domain PX PF00787.22 NM_024798.2_3 - 1.5e-13 50.6 0.1 2.5e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 PX domain Pyrophosphatase PF00719.17 NM_176867.3_3 - 8.3e-09 35.3 0.1 1.2e-08 34.8 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase DEAD_2 PF06733.13 NM_000400.3_3 - 1.4e-47 161.4 0.0 2.2e-47 160.8 0.0 1.3 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.4 NM_000400.3_3 - 5e-46 156.8 0.1 1.4e-45 155.4 0.1 1.8 2 0 0 2 2 2 1 Helicase C-terminal domain HBB PF06777.9 NM_000400.3_3 - 6.2e-46 156.4 0.1 1.2e-41 142.3 0.0 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.13 NM_000400.3_3 - 5.8e-06 26.3 0.0 0.0016 18.3 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_22 PF13401.4 NM_000400.3_3 - 0.0021 18.2 0.4 1.1 9.4 0.0 3.1 2 1 0 2 2 2 1 AAA domain SesA PF17107.3 NM_000400.3_3 - 0.036 14.1 0.3 0.2 11.7 0.1 2.2 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases PhoH PF02562.14 NM_000400.3_3 - 0.068 12.5 0.0 0.73 9.1 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein SNF2_N PF00176.21 NM_000400.3_3 - 0.083 11.5 0.3 1.1 7.8 0.3 2.1 1 1 0 1 1 1 0 SNF2 family N-terminal domain TIR_2 PF13676.4 NM_000400.3_3 - 0.13 12.5 0.1 0.59 10.4 0.1 2.3 2 0 0 2 2 2 0 TIR domain C2 PF00168.28 NM_001566.2_1 - 0.0075 16.4 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain NHR2 PF08788.9 NM_001566.2_1 - 0.0097 15.5 0.5 0.23 11.1 0.2 2.6 2 0 0 2 2 2 1 NHR2 domain like Rho_GDI PF02115.15 NM_001321420.1_3 - 1.1e-74 250.3 0.5 1.4e-74 249.9 0.5 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor AdoHcyase PF05221.15 NM_001322084.1_1 - 6.9e-129 429.1 0.0 5.1e-68 229.3 0.1 2.1 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.19 NM_001322084.1_1 - 1.2e-85 285.3 3.3 1.8e-85 284.8 3.3 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.17 NM_001322084.1_1 - 3.7e-08 32.8 0.1 7.1e-08 31.9 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.10 NM_001322084.1_1 - 8.3e-05 22.1 0.1 0.00016 21.2 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.16 NM_001322084.1_1 - 0.0065 16.6 0.1 0.011 15.8 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain 3HCDH_N PF02737.16 NM_001322084.1_1 - 0.1 12.3 0.4 0.27 11.0 0.4 1.7 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HATPase_c_3 PF13589.4 NM_001303256.2_3 - 2.6e-27 95.2 0.0 4.8e-27 94.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-CW PF07496.13 NM_001303256.2_3 - 2.8e-15 56.0 4.0 7.7e-15 54.6 4.0 1.8 1 0 0 1 1 1 1 CW-type Zinc Finger Pkinase PF00069.23 NM_001278548.1_2 - 2.1e-48 164.8 0.4 4.3e-43 147.4 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001278548.1_2 - 3.2e-23 82.2 0.1 4.5e-23 81.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_001278548.1_2 - 2.1e-06 27.1 0.2 3.3e-06 26.5 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_001278548.1_2 - 0.001 18.3 0.1 0.0016 17.7 0.1 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 NM_001278548.1_2 - 0.0043 16.5 0.4 0.0072 15.8 0.4 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 NM_001278548.1_2 - 0.0045 16.8 0.0 0.007 16.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Homeobox_KN PF05920.9 NM_001278548.1_3 - 0.11 12.3 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Homeobox KN domain LRRC37 PF15779.3 NM_199340.3_1 - 1.3e-97 320.1 186.0 1.2e-26 92.8 12.7 14.5 4 3 9 14 14 13 7 Leucine-rich repeat-containing protein 37 family LRRC37AB_C PF14914.4 NM_199340.3_1 - 2.6e-71 238.2 2.5 2.6e-71 238.2 2.5 2.1 2 0 0 2 2 2 1 LRRC37A/B like protein 1 C-terminal domain LRR_8 PF13855.4 NM_199340.3_1 - 9.2e-19 66.8 6.3 3e-14 52.4 2.6 3.1 2 1 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.5 NM_199340.3_1 - 1.8e-08 34.3 10.8 0.0004 20.6 0.4 3.6 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) CD34_antigen PF06365.10 NM_199340.3_1 - 0.00048 19.7 0.4 0.0011 18.5 0.4 1.5 1 0 0 1 1 1 1 CD34/Podocalyxin family TMEM154 PF15102.4 NM_199340.3_1 - 0.0011 18.7 0.0 0.0075 16.0 0.0 2.5 1 0 0 1 1 1 1 TMEM154 protein family LRR_5 PF13306.4 NM_199340.3_1 - 0.0047 16.7 0.3 0.0047 16.7 0.3 2.0 2 0 0 2 2 2 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_199340.3_1 - 0.013 14.9 0.1 0.041 13.2 0.1 1.8 1 1 0 1 1 1 0 Leucine-rich repeat Sarcoglycan_2 PF05510.11 NM_199340.3_1 - 0.022 13.4 0.0 0.039 12.6 0.0 1.3 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon Methuselah_N PF06652.10 NM_199340.3_1 - 0.63 9.8 5.5 0.24 11.2 1.5 2.1 2 0 0 2 2 2 0 Methuselah N-terminus LRR_6 PF13516.4 NM_199340.3_1 - 0.66 10.1 5.7 1.5 8.9 0.1 3.9 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.31 NM_199340.3_1 - 2.2 9.0 7.0 34 5.3 0.6 5.0 3 1 0 3 3 3 0 Leucine Rich Repeat OST-HTH PF12872.5 NM_001184999.1_1 - 2e-69 229.3 2.8 2.9e-13 49.4 0.0 8.6 8 0 0 8 8 8 7 OST-HTH/LOTUS domain Limkain-b1 PF11608.6 NM_001184999.1_1 - 2.9e-38 129.7 0.1 6.4e-38 128.6 0.1 1.6 1 0 0 1 1 1 1 Limkain b1 NYN PF01936.16 NM_001184999.1_1 - 8.8e-19 68.3 0.0 1.9e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 NYN domain RRM_1 PF00076.20 NM_001184999.1_1 - 6.6e-07 28.9 0.0 0.00084 19.0 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FlbD PF06289.9 NM_001184999.1_1 - 0.47 10.0 1.5 1 8.9 0.3 2.1 2 0 0 2 2 2 0 Flagellar protein (FlbD) GDA1_CD39 PF01150.15 NM_001322383.1_1 - 6.2e-11 41.5 0.0 8.7e-11 41.0 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family GDA1_CD39 PF01150.15 NM_001322383.1_3 - 3.3e-49 167.6 0.0 8.9e-49 166.2 0.0 1.6 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family zf-H2C2_2 PF13465.4 NM_001318084.1_1 - 3.9e-62 204.0 112.2 1.7e-09 37.5 1.5 15.9 16 0 0 16 16 16 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001318084.1_1 - 1.2e-49 163.9 119.7 3.6e-05 23.8 0.3 14.4 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001318084.1_1 - 6.9e-20 69.9 120.7 0.0052 17.4 0.2 15.4 15 0 0 15 15 15 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001318084.1_1 - 1.5e-07 31.0 91.7 0.023 14.5 0.1 14.6 14 0 0 14 14 14 8 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001318084.1_1 - 0.004 16.7 1.1 0.004 16.7 1.1 11.1 12 0 0 12 12 12 3 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 NM_001318084.1_1 - 0.011 15.7 63.7 0.023 14.7 1.6 9.2 7 3 4 11 11 11 0 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_001318084.1_1 - 0.043 14.4 48.2 2.8 8.6 1.8 7.6 3 3 4 8 8 8 0 zinc-ribbon family DUF3268 PF11672.6 NM_001318084.1_1 - 2.3 8.4 37.4 2.2 8.5 1.1 6.3 6 0 0 6 6 6 0 zinc-finger-containing domain ADK_lid PF05191.12 NM_001318084.1_1 - 3.2 7.7 40.9 0.3 11.0 1.2 8.4 6 1 3 9 9 9 0 Adenylate kinase, active site lid FYVE PF01363.19 NM_001318084.1_1 - 3.5 7.7 60.8 0.048 13.7 3.3 8.1 3 3 3 6 6 6 0 FYVE zinc finger SCAN PF02023.15 NM_001318084.1_2 - 2.9e-40 135.8 5.4 2.9e-40 135.8 5.4 1.8 2 0 0 2 2 2 1 SCAN domain Bestrophin PF01062.19 NM_032735.2_3 - 3.8e-109 364.5 5.6 5.1e-109 364.1 5.6 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel zf-H2C2_2 PF13465.4 NM_001114634.1_1 - 3e-17 62.1 67.3 0.00013 22.1 0.6 10.0 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001114634.1_1 - 2.3e-15 55.8 69.3 0.0077 16.8 0.8 8.5 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001114634.1_1 - 3.8e-14 52.1 72.5 0.0036 17.5 0.9 8.5 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_11 PF16622.3 NM_001114634.1_1 - 0.068 12.8 0.0 0.068 12.8 0.0 5.2 5 0 0 5 5 5 0 zinc-finger C2H2-type Acyltransf_C PF16076.3 NM_001114634.1_1 - 0.19 11.8 4.2 4 7.5 1.2 2.6 2 0 0 2 2 2 0 Acyltransferase C-terminus zf-C2H2_jaz PF12171.6 NM_001114634.1_1 - 0.38 11.0 45.5 0.22 11.8 1.0 7.0 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.3 NM_001114634.1_1 - 0.9 9.8 26.8 0.69 10.1 8.7 3.7 1 1 2 3 3 3 0 C2H2-type zinc ribbon zf-met PF12874.5 NM_001114634.1_1 - 1.1 9.6 31.3 2.5 8.4 0.2 6.1 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 NM_001114634.1_1 - 2.8 7.8 49.9 0.18 11.6 0.6 7.6 7 0 0 7 7 7 0 C2H2-type zinc finger CUB PF00431.18 NM_001135703.2_2 - 8.6e-47 157.9 1.8 3e-25 88.6 0.0 2.7 3 0 0 3 3 3 2 CUB domain Ldl_recept_a PF00057.16 NM_001135703.2_2 - 4.7e-36 122.6 78.6 4.8e-11 42.5 14.9 5.5 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A Pkinase_Tyr PF07714.15 NM_018423.2_3 - 7.1e-59 199.1 0.0 9.2e-59 198.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_018423.2_3 - 4.6e-30 104.7 0.0 6.1e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 NM_018423.2_3 - 0.0047 16.2 0.0 0.0076 15.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PAX PF00292.16 NM_003990.4_2 - 2.2e-74 247.2 0.5 3.4e-74 246.6 0.5 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 NM_003990.4_2 - 5.7e-44 148.7 10.0 1.2e-43 147.6 10.0 1.5 1 0 0 1 1 1 1 Paired-box protein 2 C terminal HTH_23 PF13384.4 NM_003990.4_2 - 0.00045 19.8 0.0 0.0011 18.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain Homeobox PF00046.27 NM_003990.4_2 - 0.036 13.7 0.1 0.077 12.7 0.1 1.4 1 0 0 1 1 1 0 Homeobox domain HTH_28 PF13518.4 NM_003990.4_2 - 0.042 13.8 0.3 0.15 12.0 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_32 PF13565.4 NM_003990.4_2 - 0.08 13.4 0.0 0.08 13.4 0.0 5.0 6 1 1 7 7 7 0 Homeodomain-like domain SMRP1 PF15181.4 NM_147169.2_1 - 9.6e-28 97.4 2.6 1.2e-27 97.0 2.6 1.1 1 0 0 1 1 1 1 Spermatid-specific manchette-related protein 1 SMRP1 PF15181.4 NM_147169.2_3 - 2.8e-07 30.3 0.7 3.2e-07 30.1 0.7 1.1 1 0 0 1 1 1 1 Spermatid-specific manchette-related protein 1 NKAIN PF05640.12 NM_153355.4_2 - 2.9e-58 196.3 14.9 2.6e-45 154.1 11.5 2.2 1 1 1 2 2 2 2 Na,K-Atpase Interacting protein Polysacc_synt_4 PF04669.11 NM_001300888.1_1 - 1.1e-07 31.4 1.2 1.8e-07 30.8 0.0 1.8 1 1 1 2 2 2 1 Polysaccharide biosynthesis MAJIN PF15077.4 NM_001300888.1_1 - 0.023 14.4 7.1 0.034 13.9 7.1 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein MMM1 PF10296.7 NM_001300888.1_1 - 0.14 11.0 4.6 0.2 10.5 4.6 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 LicD PF04991.11 NM_001300888.1_1 - 0.39 10.7 6.6 0.61 10.1 6.6 1.2 1 0 0 1 1 1 0 LicD family Zip PF02535.20 NM_001300888.1_1 - 0.75 8.8 4.0 1 8.4 4.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter LCE PF14672.4 NM_178431.1_1 - 5.6e-27 94.1 47.5 5.6e-27 94.1 47.5 1.3 2 0 0 2 2 2 1 Late cornified envelope BAT2_N PF07001.9 NM_004638.3_2 - 7.3e-71 238.5 10.6 7.3e-71 238.5 10.6 4.8 4 1 1 5 5 5 1 BAT2 N-terminus Pkinase PF00069.23 NM_013257.4_3 - 7.5e-66 222.0 0.0 9.8e-66 221.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_013257.4_3 - 3.4e-32 111.6 0.0 5e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PX PF00787.22 NM_013257.4_3 - 2.3e-22 79.0 0.2 4.4e-22 78.1 0.2 1.5 1 0 0 1 1 1 1 PX domain Pkinase_C PF00433.22 NM_013257.4_3 - 8.9e-06 26.2 3.6 4.8e-05 23.8 0.4 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_013257.4_3 - 0.00025 20.3 0.0 0.00054 19.2 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_013257.4_3 - 0.064 12.5 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Patatin PF01734.20 NM_020376.3_3 - 4.4e-15 56.3 0.6 1.3e-14 54.7 0.6 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase DUF3504 PF12012.6 NM_001320582.1_2 - 1.7e-61 206.7 0.7 1.7e-61 206.7 0.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3504) CARD PF00619.19 NM_001320582.1_2 - 0.0058 16.5 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 Caspase recruitment domain zf-C2H2 PF00096.24 NM_001317939.1_3 - 0.00016 21.8 15.5 0.13 12.7 1.3 5.0 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-met PF12874.5 NM_001317939.1_3 - 0.00038 20.6 9.1 0.028 14.7 0.1 3.6 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 NM_001317939.1_3 - 0.014 16.1 15.4 0.93 10.4 2.0 5.4 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001317939.1_3 - 0.037 14.2 6.1 1.7 8.9 1.5 3.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Kelch_1 PF01344.23 NM_020866.2_3 - 4e-84 275.9 13.2 4.7e-17 61.2 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 NM_020866.2_3 - 7.5e-51 168.7 5.7 5.3e-11 42.3 0.0 6.9 2 2 4 6 6 6 6 Kelch motif BACK PF07707.13 NM_020866.2_3 - 3.8e-31 107.1 0.2 7.7e-31 106.1 0.2 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_4 PF13418.4 NM_020866.2_3 - 3.9e-31 106.6 8.5 2.4e-07 30.4 0.0 6.4 4 2 2 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_020866.2_3 - 5.4e-29 98.9 9.7 1.1e-06 28.3 0.0 7.0 8 0 0 8 8 8 5 Kelch motif BTB PF00651.29 NM_020866.2_3 - 1.8e-28 98.8 0.4 3.6e-28 97.9 0.4 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.4 NM_020866.2_3 - 2.8e-23 81.5 11.6 2.9e-08 33.6 0.1 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_020866.2_3 - 5.1e-06 26.2 3.5 0.52 10.2 0.0 6.1 6 0 0 6 6 6 1 Kelch motif Glu_cyclase_2 PF05096.10 NM_020866.2_3 - 0.14 11.5 0.0 6.8 5.9 0.0 2.4 2 1 1 3 3 3 0 Glutamine cyclotransferase RPA_C PF08784.9 NM_002946.4_1 - 6.6e-26 90.9 0.0 1.4e-25 89.8 0.0 1.6 1 0 0 1 1 1 1 Replication protein A C terminal tRNA_anti-codon PF01336.23 NM_002946.4_1 - 0.00013 21.7 0.0 0.00022 21.0 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain MarR_2 PF12802.5 NM_002946.4_1 - 0.13 12.0 0.0 0.35 10.7 0.0 1.7 1 0 0 1 1 1 0 MarR family RMI2 PF16100.3 NM_002946.4_1 - 0.18 11.5 0.2 13 5.5 0.0 2.2 1 1 1 2 2 2 0 RecQ-mediated genome instability protein 2 Ribosomal_L36e PF01158.16 NM_033643.2_1 - 3.1e-51 171.4 8.4 4.8e-51 170.8 8.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L36e p47_phox_C PF08944.9 NM_033643.2_3 - 0.021 14.1 0.4 0.058 12.7 0.4 1.7 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain FGF PF00167.16 NM_004112.3_1 - 4.4e-38 130.1 0.0 6.4e-38 129.5 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 NM_004112.3_1 - 0.0054 16.8 0.0 0.014 15.5 0.0 1.6 2 0 0 2 2 2 1 Fascin domain OLF PF02191.14 NM_001288823.1_3 - 3e-81 272.5 9.9 4.3e-81 272.0 9.9 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.6 NM_001288823.1_3 - 1.1e-48 163.1 1.7 1.1e-48 163.1 1.7 1.9 2 0 0 2 2 2 1 Neurogenesis glycoprotein Dynactin_p22 PF07426.9 NM_001288823.1_3 - 0.2 11.4 6.8 0.26 11.0 6.2 1.4 1 1 0 1 1 1 0 Dynactin subunit p22 CENP-Q PF13094.4 NM_001288823.1_3 - 2.2 8.3 5.9 4 7.5 5.9 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Peptidase_M14 PF00246.22 NM_001869.2_2 - 1.3e-92 310.6 0.0 1.6e-92 310.2 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.14 NM_001869.2_2 - 4.7e-21 74.8 0.7 9.8e-21 73.8 0.7 1.6 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Gp_dh_C PF02800.18 NM_001289746.1_1 - 2.8e-69 231.6 0.0 3.9e-69 231.1 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 NM_001289746.1_1 - 4.5e-39 132.8 0.1 9.1e-39 131.8 0.1 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.18 NM_001289746.1_1 - 0.075 13.0 0.1 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.17 NM_001289746.1_1 - 0.12 11.6 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain A_deaminase PF00962.20 NM_203404.1_2 - 2.6e-134 447.6 1.2 4.1e-134 446.9 1.2 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase RRM_1 PF00076.20 NM_144770.4_1 - 1.4e-14 53.5 0.0 2.3e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cas_Cas2CT1978 PF09707.8 NM_144770.4_1 - 0.17 11.8 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas2CT1978) CD225 PF04505.10 NM_021034.2_3 - 1.5e-32 111.4 0.8 2.2e-32 110.8 0.8 1.2 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Phage_holin_2_3 PF16080.3 NM_021034.2_3 - 0.16 11.6 1.5 0.31 10.7 1.5 1.5 1 0 0 1 1 1 0 Bacteriophage holin family HP1 BAR PF03114.16 NM_018054.5_1 - 1e-64 218.3 8.0 1.8e-64 217.5 8.0 1.4 1 0 0 1 1 1 1 BAR domain RhoGAP PF00620.25 NM_018054.5_1 - 3e-43 147.1 0.0 6.4e-43 146.1 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain BAR_2 PF10455.7 NM_018054.5_1 - 0.0061 15.6 3.6 0.012 14.6 1.1 2.1 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking FliJ PF02050.14 NM_018054.5_1 - 0.062 13.4 0.3 0.062 13.4 0.3 2.3 3 0 0 3 3 3 0 Flagellar FliJ protein T2SSM PF04612.10 NM_018054.5_1 - 0.79 9.6 3.3 21 5.0 0.0 3.2 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein M MscS_porin PF12795.5 NM_018054.5_1 - 4.8 6.5 10.1 2.5 7.4 1.9 3.5 4 0 0 4 4 4 0 Mechanosensitive ion channel porin domain Mod_r PF07200.11 NM_018054.5_1 - 7.1 6.6 10.0 3.2 7.7 0.2 2.7 2 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF678 PF05077.10 NM_013238.2_2 - 8.2 6.5 13.1 0.027 14.5 3.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF678) DnaJ PF00226.29 NM_013238.2_3 - 6e-05 23.0 0.0 9.8e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF3918 PF13056.4 NM_013238.2_3 - 0.046 13.2 0.6 0.087 12.3 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) SHMT PF00464.17 NM_001166359.1_1 - 1.6e-209 695.3 0.0 1.9e-209 695.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase UPF1_Zn_bind PF09416.8 NM_001297549.1_3 - 6.5e-75 250.1 6.7 1.8e-74 248.6 6.9 1.7 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.4 NM_001297549.1_3 - 2.9e-61 206.5 0.0 4.5e-61 205.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.4 NM_001297549.1_3 - 2.2e-48 165.1 2.3 1.4e-26 93.7 0.4 2.3 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.4 NM_001297549.1_3 - 4.5e-13 49.2 0.0 3.9e-12 46.2 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.4 NM_001297549.1_3 - 4.1e-10 40.0 0.0 1.2e-09 38.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain ResIII PF04851.13 NM_001297549.1_3 - 2.8e-05 24.1 0.0 5.3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.7 NM_001297549.1_3 - 0.00044 19.5 0.0 0.013 14.6 0.0 2.5 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.12 NM_001297549.1_3 - 0.00074 19.3 0.0 0.0018 18.0 0.0 1.6 1 0 0 1 1 1 1 Helicase ATPase PF06745.11 NM_001297549.1_3 - 0.0023 17.2 0.0 0.025 13.8 0.0 2.0 2 0 0 2 2 2 1 KaiC SRP54 PF00448.20 NM_001297549.1_3 - 0.0099 15.4 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain UvrD-helicase PF00580.19 NM_001297549.1_3 - 0.084 12.2 0.3 1.6 8.1 0.0 2.4 2 1 0 3 3 3 0 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.4 NM_001297549.1_3 - 0.11 12.2 0.0 0.59 9.9 0.0 2.2 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain PIF1 PF05970.12 NM_001297549.1_3 - 0.15 11.1 0.0 8.5 5.3 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_10 PF12846.5 NM_001297549.1_3 - 0.21 10.3 0.0 0.34 9.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain SDF PF00375.16 NM_001289940.1_3 - 4.1e-104 348.6 29.4 8.9e-80 268.5 15.2 2.1 1 1 1 2 2 2 2 Sodium:dicarboxylate symporter family UCH PF00443.27 NM_005153.2_2 - 1.7e-43 148.8 0.1 2.3e-43 148.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_005153.2_2 - 5.3e-16 59.0 0.0 6.1e-15 55.5 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PAM2 PF07145.13 NM_005153.2_2 - 0.00014 21.2 0.0 0.00033 20.0 0.0 1.7 1 0 0 1 1 1 1 Ataxin-2 C-terminal region YukD PF08817.8 NM_005153.2_2 - 0.099 13.2 0.3 1.1 9.9 0.0 2.6 3 0 0 3 3 3 0 WXG100 protein secretion system (Wss), protein YukD Ion_trans_2 PF07885.14 NM_014217.3_1 - 1.7e-36 123.9 27.0 1.3e-18 66.5 13.8 3.8 3 1 1 4 4 4 3 Ion channel bZIP_Maf PF03131.15 NM_014217.3_1 - 0.057 13.8 0.9 0.099 13.0 0.9 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor Occludin_ELL PF07303.11 NM_024578.2_3 - 3.4e-25 88.5 0.0 5e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Occludin homology domain PDZ PF00595.22 NM_001301128.1_3 - 4e-67 222.4 9.8 6.1e-15 55.2 0.0 6.4 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) MAGI_u1 PF16663.3 NM_001301128.1_3 - 7.7e-28 96.1 3.7 1.9e-27 94.8 3.7 1.8 1 0 0 1 1 1 1 Unstructured region on MAGI PDZ_2 PF13180.4 NM_001301128.1_3 - 1e-24 86.5 0.2 7.3e-05 22.9 0.0 5.5 5 0 0 5 5 5 5 PDZ domain WW PF00397.24 NM_001301128.1_3 - 3.8e-16 58.6 4.3 1.5e-09 37.5 0.3 2.5 2 0 0 2 2 2 2 WW domain MAGI_u5 PF16666.3 NM_001301128.1_3 - 1.9e-13 50.6 4.3 1.9e-13 50.6 4.3 5.8 5 1 0 5 5 5 1 Unstructured region on MAGI Guanylate_kin PF00625.19 NM_001301128.1_3 - 6.2e-10 38.9 0.0 1.1e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.4 NM_001301128.1_3 - 5.4e-05 23.0 2.3 3.9 7.4 0.0 4.6 5 0 0 5 5 5 2 Tricorn protease PDZ domain CDK5_activator PF03261.13 NM_003936.4_2 - 2.6e-93 313.3 0.1 1.6e-88 297.5 0.0 2.0 2 0 0 2 2 2 2 Cyclin-dependent kinase 5 activator protein TFIID-31kDa PF02291.13 NM_003187.4_3 - 9.1e-51 170.9 0.0 1.4e-50 170.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit AAA_18 PF13238.4 NM_003187.4_3 - 1.9e-07 31.5 0.0 3.6e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain CENP-S PF15630.4 NM_003187.4_3 - 2.8e-06 27.5 0.1 5.4e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 CENP-S protein AAA_17 PF13207.4 NM_003187.4_3 - 2.9e-05 24.4 0.1 2.9e-05 24.4 0.1 1.7 2 0 0 2 2 1 1 AAA domain Bromo_TP PF07524.11 NM_003187.4_3 - 0.00011 22.0 0.0 0.0002 21.2 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated AAA PF00004.27 NM_003187.4_3 - 0.0002 21.7 0.7 0.00037 20.8 0.6 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.4 NM_003187.4_3 - 0.00024 21.3 0.0 0.00036 20.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Histone PF00125.22 NM_003187.4_3 - 0.00064 20.0 0.3 0.00064 20.0 0.3 1.7 2 0 0 2 2 1 1 Core histone H2A/H2B/H3/H4 AAA_16 PF13191.4 NM_003187.4_3 - 0.0031 17.8 0.1 0.006 16.8 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain CENP-T_C PF15511.4 NM_003187.4_3 - 0.0039 17.1 0.1 0.0072 16.3 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold AAA_33 PF13671.4 NM_003187.4_3 - 0.014 15.4 0.7 0.056 13.5 0.7 2.0 1 1 0 1 1 1 0 AAA domain SKI PF01202.20 NM_003187.4_3 - 0.018 15.1 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 Shikimate kinase NTPase_1 PF03266.13 NM_003187.4_3 - 0.02 14.6 0.4 0.033 14.0 0.4 1.3 1 0 0 1 1 1 0 NTPase AAA_22 PF13401.4 NM_003187.4_3 - 0.024 14.8 0.1 0.05 13.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain ADK PF00406.20 NM_003187.4_3 - 0.028 14.4 0.1 0.044 13.7 0.1 1.3 1 0 0 1 1 1 0 Adenylate kinase AAA_5 PF07728.12 NM_003187.4_3 - 0.044 13.6 0.2 0.1 12.5 0.2 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TsaE PF02367.15 NM_003187.4_3 - 0.049 13.5 0.1 0.095 12.6 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.10 NM_003187.4_3 - 0.066 12.3 0.1 0.11 11.6 0.1 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Cytidylate_kin PF02224.16 NM_003187.4_3 - 0.067 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase ATPase PF06745.11 NM_003187.4_3 - 0.076 12.2 0.3 0.3 10.3 0.1 1.9 2 0 0 2 2 2 0 KaiC AAA_24 PF13479.4 NM_003187.4_3 - 0.085 12.4 0.2 0.16 11.5 0.2 1.4 1 0 0 1 1 1 0 AAA domain AAA_32 PF13654.4 NM_003187.4_3 - 0.12 11.1 0.2 0.92 8.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.23 NM_001324328.1_1 - 1.2e-71 241.0 0.0 2e-71 240.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001324328.1_1 - 1.2e-44 152.4 0.0 2e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 NM_001324328.1_1 - 7.4e-19 67.8 0.0 1.6e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 NM_001324328.1_1 - 1.2e-05 24.7 0.0 0.0024 17.1 0.0 2.4 1 1 1 2 2 2 2 Kinase-like DSHCT PF08148.10 NM_001324328.1_1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain APH PF01636.21 NM_001324328.1_1 - 0.15 11.8 0.1 0.44 10.3 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Ribosomal_60s PF00428.17 NM_001324328.1_1 - 6.7 7.2 9.2 0.27 11.7 2.4 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein BRCT_2 PF16589.3 NM_001321458.1_2 - 8.4e-10 38.8 0.0 1.6e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain IMS PF00817.18 NM_001321458.1_2 - 3.9e-08 33.3 0.0 6.3e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 impB/mucB/samB family BRCT PF00533.24 NM_001321458.1_2 - 1e-06 28.9 0.0 2.5e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.3 NM_001321458.1_2 - 2.3e-05 24.5 0.0 4.2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.5 NM_001321458.1_2 - 0.00024 20.8 0.2 0.0006 19.6 0.0 1.7 2 0 0 2 2 2 1 twin BRCT domain REV1_C PF16727.3 NM_001321458.1_3 - 2.9e-41 140.2 0.0 6.3e-41 139.1 0.0 1.6 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain IMS PF00817.18 NM_001321458.1_3 - 1.4e-25 89.9 0.0 3e-25 88.8 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.6 NM_001321458.1_3 - 1.3e-15 58.0 0.0 3e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain DUF4414 PF14377.4 NM_001321458.1_3 - 2.6e-09 37.3 10.5 1.6e-07 31.5 4.9 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF4414) IMS_HHH PF11798.6 NM_001321458.1_3 - 0.00027 21.0 0.0 0.018 15.2 0.0 2.8 2 0 0 2 2 2 1 IMS family HHH motif Cdd1 PF11731.6 NM_001321458.1_3 - 0.0073 16.4 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 Pathogenicity locus DUF2457 PF10446.7 NM_001321458.1_3 - 0.36 9.8 1.3 0.63 9.0 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TMEM132 PF16070.3 NM_001136103.2_1 - 1.9e-145 484.4 3.6 2.5e-145 484.0 3.6 1.1 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_N PF15705.3 NM_001136103.2_1 - 9.3e-58 193.6 0.0 2.1e-57 192.4 0.0 1.6 2 0 0 2 2 2 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term TMEM132D_C PF15706.3 NM_001136103.2_1 - 1.3e-37 127.3 0.0 2.4e-37 126.4 0.0 1.5 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term HCO3_cotransp PF00955.19 NM_001174090.1_3 - 1.3e-146 489.4 1.8 1.9e-146 488.8 1.8 1.2 1 0 0 1 1 1 1 HCO3- transporter family PTS_EIIA_2 PF00359.20 NM_001174090.1_3 - 0.0002 21.1 0.0 0.0011 18.7 0.0 2.1 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Band_3_cyto PF07565.11 NM_001174090.1_3 - 0.0058 16.3 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain LSM PF01423.20 NM_001317166.1_3 - 5.2e-19 67.6 0.1 7e-19 67.1 0.1 1.2 1 0 0 1 1 1 1 LSM domain WD40 PF00400.30 NM_001317063.1_2 - 3.3e-06 27.6 21.9 4.7e-05 23.9 0.1 6.3 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001317063.1_2 - 0.00075 19.6 0.7 0.038 14.2 0.0 3.0 1 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.6 NM_001317063.1_2 - 0.0021 16.3 0.2 0.0029 15.9 0.2 1.1 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz PH PF00169.27 NM_001130700.1_1 - 1.2e-15 57.8 1.9 2.6e-15 56.7 1.9 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 NM_001130700.1_1 - 0.0056 16.9 3.2 0.11 12.7 3.2 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain LEM PF03020.13 NM_001199052.1_1 - 2e-07 30.3 0.0 3.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 LEM domain ABC_membrane PF00664.21 NM_001144070.1_3 - 8.2e-28 97.7 10.4 8.2e-28 97.7 10.4 1.9 2 0 0 2 2 2 1 ABC transporter transmembrane region DUF4604 PF15377.4 NM_001144070.1_3 - 5.8 7.2 24.0 3.3 8.0 16.5 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4604) TP2 PF01254.16 NM_005425.4_3 - 3e-61 205.9 37.0 3.6e-61 205.6 37.0 1.1 1 0 0 1 1 1 1 Nuclear transition protein 2 TMIE PF16038.3 NM_005425.4_3 - 0.022 14.5 1.5 0.038 13.7 1.5 1.3 1 0 0 1 1 1 0 TMIE protein FA_desaturase PF00487.22 NM_001321541.1_1 - 7.1e-22 78.3 15.7 7.1e-22 78.3 15.7 1.4 1 1 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.8 NM_001321541.1_1 - 1.1e-20 72.7 0.6 2.2e-20 71.7 0.6 1.5 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) DUF4061 PF13270.4 NM_015439.2_3 - 5.3e-30 103.5 4.2 8.4e-30 102.9 4.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) TruB_C_2 PF16198.3 NM_001317842.1_3 - 0.12 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 tRNA pseudouridylate synthase B C-terminal domain CENP-I PF07778.9 NM_001318523.1_2 - 5.2e-285 945.8 12.4 6e-285 945.6 12.4 1.0 1 0 0 1 1 1 1 Mis6 DSPc PF00782.18 NM_001007273.1_1 - 1.4e-25 89.5 0.0 1.9e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 NM_001007273.1_1 - 0.00065 19.2 0.1 0.00098 18.6 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FAM110_C PF14160.4 NM_001077710.2_3 - 1.1e-37 129.4 0.0 1.6e-37 128.9 0.0 1.2 1 0 0 1 1 1 1 Centrosome-associated C terminus FAM110_N PF14161.4 NM_001077710.2_3 - 5.3e-05 23.3 0.7 0.00011 22.3 0.7 1.4 1 0 0 1 1 1 1 Centrosome-associated N terminus Myotub-related PF06602.12 NM_001077525.2_2 - 0.00036 19.5 0.0 0.00059 18.8 0.0 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.4 NM_001077525.2_2 - 0.00078 19.3 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.25 NM_001077525.2_2 - 0.015 14.8 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Ank_2 PF12796.5 NM_000037.3_1 - 8.4e-153 497.2 35.7 1.2e-18 67.3 0.5 12.1 1 1 11 12 12 12 12 Ankyrin repeats (3 copies) Ank PF00023.28 NM_000037.3_1 - 3.3e-133 428.7 62.4 1.7e-07 31.3 0.0 23.1 23 0 0 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 NM_000037.3_1 - 1.4e-126 411.2 32.7 4.6e-13 49.3 0.2 15.9 5 4 10 17 17 17 17 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_000037.3_1 - 2.1e-121 393.7 47.5 8.5e-12 45.0 0.0 18.5 4 3 16 20 20 20 19 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_000037.3_1 - 9.4e-118 369.6 40.0 5.5e-06 26.2 0.0 23.5 23 0 0 23 23 23 20 Ankyrin repeat ZU5 PF00791.18 NM_000037.3_1 - 3.7e-33 113.6 0.1 1.7e-26 92.2 0.0 2.7 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 NM_000037.3_1 - 1.2e-25 89.3 0.3 2.7e-25 88.2 0.3 1.6 1 0 0 1 1 1 1 Death domain BK_channel_a PF03493.16 NM_198503.3_3 - 3.6e-31 107.2 0.1 1.2e-30 105.4 0.1 2.0 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.14 NM_198503.3_3 - 8.5e-14 51.2 3.7 5.4e-13 48.6 3.9 2.3 3 0 0 3 3 3 1 Ion channel Anophelin PF10731.7 NM_198503.3_3 - 0.097 12.4 0.7 0.23 11.2 0.7 1.6 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito Arm_2 PF04826.11 NM_001161010.2_3 - 1e-74 251.1 9.1 2.7e-40 138.3 0.7 2.1 1 1 1 2 2 2 2 Armadillo-like V-ATPase_H_C PF11698.6 NM_001161010.2_3 - 0.032 14.2 2.4 0.053 13.5 1.0 2.0 2 0 0 2 2 2 0 V-ATPase subunit H Atx10homo_assoc PF09759.7 NM_001161010.2_3 - 0.04 13.9 0.5 0.079 12.9 0.5 1.5 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain Arm PF00514.21 NM_001161010.2_3 - 0.092 12.7 3.6 0.1 12.6 0.2 2.6 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Arm_3 PF16186.3 NM_001161010.2_3 - 0.28 10.6 1.5 8.3 5.9 0.1 2.3 2 0 0 2 2 2 0 Atypical Arm repeat Acyltransferase PF01553.19 NM_001304445.1_1 - 5.9e-21 74.4 0.0 1.1e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.3 NM_001304445.1_1 - 7.5e-18 64.3 0.3 1.4e-17 63.5 0.3 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus UNC45-central PF11701.6 NM_001323619.1_2 - 9.6e-38 129.4 10.2 3.7e-36 124.2 0.1 4.9 5 0 0 5 5 4 1 Myosin-binding striated muscle assembly central TPR_2 PF07719.15 NM_001323619.1_2 - 1.3e-12 46.6 11.1 0.00013 21.6 0.0 4.2 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001323619.1_2 - 1.1e-11 43.9 9.5 0.0019 17.8 0.0 4.0 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001323619.1_2 - 6.4e-09 36.2 4.1 3.6e-05 24.2 0.9 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001323619.1_2 - 2.2e-08 33.6 6.7 0.0002 21.2 0.0 4.3 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001323619.1_2 - 2.6e-06 27.6 5.1 0.014 16.0 0.1 5.0 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001323619.1_2 - 1.1e-05 25.7 5.8 0.0035 17.7 2.2 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001323619.1_2 - 1.8e-05 24.2 1.4 0.0023 17.4 0.3 3.0 1 1 2 3 3 3 1 TPR repeat TPR_17 PF13431.4 NM_001323619.1_2 - 2.5e-05 24.2 0.4 0.078 13.3 0.0 3.4 3 0 0 3 3 2 2 Tetratricopeptide repeat HEAT_2 PF13646.4 NM_001323619.1_2 - 2.7e-05 24.3 9.6 1 9.7 0.1 6.2 4 2 2 7 7 7 2 HEAT repeats TPR_12 PF13424.4 NM_001323619.1_2 - 0.00015 21.9 3.3 0.006 16.7 2.3 3.1 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001323619.1_2 - 0.0013 18.7 2.2 0.05 13.6 0.2 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001323619.1_2 - 0.0026 17.8 1.1 0.0088 16.1 1.1 2.0 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.4 NM_001323619.1_2 - 0.003 17.3 1.4 1.2 9.3 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Coatomer_E PF04733.12 NM_001323619.1_2 - 0.032 13.5 0.1 0.067 12.5 0.1 1.4 1 0 0 1 1 1 0 Coatomer epsilon subunit RIX1 PF08167.10 NM_001323619.1_2 - 0.048 13.3 2.5 0.22 11.1 0.2 2.8 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis Arm PF00514.21 NM_001323619.1_2 - 0.061 13.3 10.9 3 7.9 0.0 7.1 8 1 0 8 8 8 0 Armadillo/beta-catenin-like repeat TPR_6 PF13174.4 NM_001323619.1_2 - 0.12 12.9 0.1 0.12 12.9 0.1 4.1 5 0 0 5 5 2 0 Tetratricopeptide repeat HEAT PF02985.20 NM_001323619.1_2 - 0.77 10.0 4.5 18 5.8 0.0 5.4 6 0 0 6 6 4 0 HEAT repeat DUF3736 PF12540.6 NM_001278184.1_1 - 5.8e-58 194.7 18.0 1.9e-43 147.7 8.3 4.9 5 1 0 5 5 5 2 Protein of unknown function (DUF3736) MIP-T3 PF10243.7 NM_001278184.1_1 - 0.00046 18.9 18.2 0.00046 18.9 18.2 2.3 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 IL1_propep PF02394.14 NM_000575.4_2 - 9.5e-39 132.5 2.3 1.6e-38 131.8 2.3 1.4 1 0 0 1 1 1 1 Interleukin-1 propeptide IL1 PF00340.17 NM_000575.4_2 - 1.3e-35 121.5 0.0 2.2e-35 120.8 0.0 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 Ldl_recept_a PF00057.16 NM_002332.2_2 - 1.6e-292 943.3 601.7 1.7e-12 47.2 7.5 34.2 34 0 0 34 34 34 31 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 NM_002332.2_2 - 5.3e-210 679.6 86.9 5e-14 52.4 0.1 36.4 36 1 0 36 36 36 30 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 NM_002332.2_2 - 7.4e-62 205.2 383.5 1.6e-10 40.9 10.8 27.5 22 2 4 26 26 26 16 Coagulation Factor Xa inhibitory site DUF5050 PF16472.3 NM_002332.2_2 - 2.2e-31 109.0 0.0 1.9e-10 40.3 0.0 7.9 8 0 0 8 8 8 6 Domain of unknown function (DUF5050) SGL PF08450.10 NM_002332.2_2 - 7.3e-25 87.8 35.1 0.0023 17.4 0.0 16.0 10 7 3 14 14 14 7 SMP-30/Gluconolaconase/LRE-like region cEGF PF12662.5 NM_002332.2_2 - 4.9e-13 48.6 127.2 8.5e-09 35.1 1.1 16.9 15 0 0 15 15 15 8 Complement Clr-like EGF-like EGF_CA PF07645.13 NM_002332.2_2 - 1.9e-09 37.4 21.8 2.1e-07 30.9 6.2 33.9 27 11 10 38 38 38 4 Calcium-binding EGF domain Arylesterase PF01731.18 NM_002332.2_2 - 0.00044 20.3 0.0 18 5.5 0.0 6.9 9 0 0 9 9 9 0 Arylesterase EGF PF00008.25 NM_002332.2_2 - 0.00086 19.4 9.4 0.00086 19.4 9.4 37.7 39 2 1 40 40 40 11 EGF-like domain TadE PF07811.10 NM_002332.2_2 - 0.16 12.2 1.8 0.5 10.6 1.8 1.9 1 0 0 1 1 1 0 TadE-like protein LRR_8 PF13855.4 NM_001129890.1_2 - 6.4e-30 102.6 41.8 2.1e-10 40.1 5.2 4.3 1 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 NM_001129890.1_2 - 4.2e-19 68.1 31.4 9e-06 25.8 0.8 6.3 3 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_001129890.1_2 - 1.1e-10 41.2 16.7 2.9e-07 30.0 2.7 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.31 NM_001129890.1_2 - 0.002 18.2 31.6 1 9.9 0.0 9.2 8 1 1 9 9 9 1 Leucine Rich Repeat LRR_2 PF07723.11 NM_001129890.1_2 - 0.008 16.7 0.1 2.1 9.0 0.0 3.8 3 0 0 3 3 3 1 Leucine Rich Repeat RsmF_methylt_CI PF17126.3 NM_001129890.1_2 - 0.014 15.3 0.9 4.5 7.3 0.1 4.1 3 1 0 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain Isochorismatase PF00857.18 NM_016048.2_1 - 7.4e-25 88.0 0.0 1.1e-24 87.4 0.0 1.3 1 0 0 1 1 1 1 Isochorismatase family BACK PF07707.13 NM_198439.2_2 - 2.7e-26 91.5 2.7 4.8e-26 90.7 2.7 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 NM_198439.2_2 - 1.7e-24 86.1 1.5 1.7e-24 86.1 1.5 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_6 PF13964.4 NM_198439.2_2 - 4.8e-20 71.0 5.1 8.5e-05 22.6 0.0 6.7 3 1 3 6 6 6 4 Kelch motif Kelch_1 PF01344.23 NM_198439.2_2 - 2.7e-19 68.3 3.6 4.6e-05 22.8 0.0 5.8 5 1 0 5 5 5 4 Kelch motif Kelch_4 PF13418.4 NM_198439.2_2 - 1.4e-07 31.2 0.0 0.48 10.3 0.0 5.5 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_198439.2_2 - 1.8e-07 30.7 0.3 0.028 14.3 0.0 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.4 NM_198439.2_2 - 1.2e-06 28.5 0.2 1.5 9.1 0.0 4.9 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_198439.2_2 - 0.045 13.6 0.3 3.2 7.7 0.0 3.3 3 0 0 3 3 3 0 Kelch motif Pkinase PF00069.23 NM_172171.2_2 - 5e-74 248.8 0.0 6.9e-74 248.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CaMKII_AD PF08332.8 NM_172171.2_2 - 1.7e-59 199.4 0.0 2.8e-59 198.7 0.0 1.4 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.15 NM_172171.2_2 - 6.1e-34 117.3 0.0 1.1e-33 116.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase SnoaL_3 PF13474.4 NM_172171.2_2 - 2.2e-10 40.7 0.0 3.8e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.4 NM_172171.2_2 - 2.5e-09 37.3 0.0 4.8e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Kdo PF06293.12 NM_172171.2_2 - 0.017 14.4 0.2 0.037 13.2 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_172171.2_2 - 0.021 14.6 0.1 2.4 7.9 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family SnoaL_2 PF12680.5 NM_172171.2_2 - 0.096 13.2 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 SnoaL-like domain IMS PF00817.18 NM_007195.2_3 - 3.4e-45 153.5 0.0 4.9e-45 153.0 0.0 1.2 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.6 NM_007195.2_3 - 6.1e-11 42.9 0.0 1.8e-10 41.4 0.0 1.7 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain Cdd1 PF11731.6 NM_007195.2_3 - 6.5e-05 23.0 0.0 0.00014 21.9 0.0 1.5 1 0 0 1 1 1 1 Pathogenicity locus IMS_HHH PF11798.6 NM_007195.2_3 - 0.00019 21.4 0.0 0.0004 20.4 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif DUF4414 PF14377.4 NM_007195.2_3 - 0.0012 18.9 0.1 1.3 9.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4414) HHH_5 PF14520.4 NM_007195.2_3 - 0.087 13.3 0.0 0.18 12.4 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.7 NM_007195.2_3 - 0.091 12.5 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda DUF4332 PF14229.4 NM_007195.2_3 - 0.1 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) TfoX_C PF04994.11 NM_007195.2_3 - 0.11 12.5 0.0 0.27 11.2 0.0 1.7 2 0 0 2 2 2 0 TfoX C-terminal domain Cobalamin_bind PF01122.17 NM_001184726.1_1 - 5e-98 327.8 0.0 3.3e-69 233.0 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic cobalamin-binding protein DUF4430 PF14478.4 NM_001184726.1_1 - 3e-06 27.6 0.0 4.6e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) BRICHOS PF04089.12 NM_001287240.1_2 - 9.2e-21 73.6 0.0 1.4e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain Asn_synthase PF00733.19 NM_019048.2_3 - 1.1e-17 64.6 0.0 7e-06 25.8 0.0 3.2 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.4 NM_019048.2_3 - 1.1e-05 25.2 0.0 2.7e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain Prefoldin_2 PF01920.18 NM_019048.2_3 - 0.08 12.8 6.6 0.19 11.5 6.6 1.6 1 0 0 1 1 1 0 Prefoldin subunit Methyltransf_23 PF13489.4 NM_017421.3_1 - 1e-22 80.7 0.0 1.7e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_017421.3_1 - 2.9e-21 75.8 0.1 6.2e-21 74.7 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_017421.3_1 - 1.2e-16 61.0 0.0 2.9e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_017421.3_1 - 2.4e-13 50.5 0.0 4.4e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_017421.3_1 - 3.7e-13 49.4 0.0 6.2e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.18 NM_017421.3_1 - 4.8e-10 39.1 0.0 6.7e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.16 NM_017421.3_1 - 2.3e-07 30.2 0.0 3.4e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 NM_017421.3_1 - 1.3e-05 24.7 0.0 2.7e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.11 NM_017421.3_1 - 4.6e-05 22.8 0.0 7.1e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.9 NM_017421.3_1 - 9.6e-05 21.3 0.0 0.00015 20.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) NodS PF05401.9 NM_017421.3_1 - 9.9e-05 21.9 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_PK PF05891.10 NM_017421.3_1 - 0.0012 18.3 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Pox_MCEL PF03291.14 NM_017421.3_1 - 0.011 14.7 0.0 0.14 11.1 0.0 2.0 1 1 0 1 1 1 0 mRNA capping enzyme Methyltransf_15 PF09445.8 NM_017421.3_1 - 0.012 15.2 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_32 PF13679.4 NM_017421.3_1 - 0.093 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Sugar_tr PF00083.22 NM_014849.4_3 - 9.3e-33 113.6 22.2 1e-27 97.0 7.2 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 NM_014849.4_3 - 1.2e-31 109.8 35.0 4.1e-22 78.5 16.6 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Pentapeptide_4 PF13599.4 NM_014849.4_3 - 2.8e-06 27.2 7.1 5.1e-06 26.4 7.1 1.3 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) MFS_4 PF06779.12 NM_014849.4_3 - 0.0009 18.5 7.4 0.0009 18.5 7.4 2.3 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.4 NM_014849.4_3 - 0.0018 16.8 10.7 0.0018 16.8 10.7 2.4 2 0 0 2 2 2 1 MFS/sugar transport protein Pentapeptide PF00805.20 NM_014849.4_3 - 0.023 14.2 0.6 0.051 13.1 0.6 1.6 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.4 NM_014849.4_3 - 0.027 14.5 8.7 1.5 8.9 4.6 2.6 1 1 0 2 2 2 0 Pentapeptide repeats (9 copies) MFS_3 PF05977.11 NM_014849.4_3 - 0.25 9.6 9.3 0.38 9.0 4.7 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector TAS2R PF05296.11 NM_176888.2_2 - 2.4e-85 286.2 42.8 2.4e-85 286.2 42.8 1.2 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) NnrS PF05940.10 NM_176888.2_2 - 0.36 10.0 23.3 0.46 9.7 22.3 1.7 1 1 0 1 1 1 0 NnrS protein DUF1345 PF07077.9 NM_176888.2_2 - 0.56 9.7 13.9 0.086 12.4 0.4 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1345) Cullin PF00888.20 NM_003591.3_3 - 1.9e-174 581.5 22.5 2.5e-174 581.2 22.5 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 NM_003591.3_3 - 2.4e-26 91.4 4.7 2.4e-26 91.4 4.7 2.8 3 0 0 3 3 3 1 Cullin protein neddylation domain Rio2_N PF09202.9 NM_003591.3_3 - 0.0092 16.0 1.1 0.022 14.9 0.2 2.0 2 0 0 2 2 2 1 Rio2, N-terminal LRR_8 PF13855.4 NM_001318479.1_2 - 1.4e-34 117.5 14.5 3.8e-12 45.6 1.7 5.3 2 2 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 NM_001318479.1_2 - 3.2e-16 58.9 19.6 0.0017 18.6 0.2 7.3 2 2 4 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001318479.1_2 - 7.1e-10 37.8 14.3 1.7 9.3 0.0 10.2 7 1 2 9 9 9 2 Leucine Rich Repeat LRR_5 PF13306.4 NM_001318479.1_2 - 3.6e-07 30.1 0.0 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_6 PF13516.4 NM_001318479.1_2 - 7.5e-05 22.3 22.4 0.77 9.8 0.1 8.9 10 0 0 10 10 10 1 Leucine Rich repeat PALP PF00291.23 NM_001304803.1_1 - 1.3e-60 205.1 0.2 1.8e-60 204.7 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme LBP_BPI_CETP PF01273.23 NM_001243193.1_2 - 9.1e-40 135.8 0.8 1.2e-39 135.4 0.8 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain C2 PF00168.28 NM_133337.2_1 - 4.3e-98 322.4 2.7 4.2e-19 68.6 0.1 8.5 7 1 0 7 7 7 7 C2 domain FerB PF08150.10 NM_133337.2_1 - 1.5e-31 108.7 0.0 3.4e-31 107.6 0.0 1.7 1 0 0 1 1 1 1 FerB (NUC096) domain Ferlin_C PF16165.3 NM_133337.2_1 - 9.2e-30 103.5 1.7 1.3e-25 90.0 0.1 2.5 1 1 1 2 2 2 2 Ferlin C-terminus FerA PF08165.9 NM_133337.2_1 - 2.3e-23 81.7 0.1 6.9e-23 80.3 0.1 1.9 1 0 0 1 1 1 1 FerA (NUC095) domain FerI PF08151.10 NM_133337.2_1 - 2.4e-20 72.3 0.4 4.9e-20 71.2 0.4 1.6 1 0 0 1 1 1 1 FerI (NUC094) domain PI3K_C2 PF00792.22 NM_133337.2_1 - 0.0037 17.2 0.2 6.5 6.7 0.0 3.2 4 0 0 4 4 4 2 Phosphoinositide 3-kinase C2 DHDPS PF00701.20 NM_138413.3_3 - 1.8e-48 164.6 0.0 2.4e-48 164.2 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PDEase_I PF00233.17 NM_001037340.2_1 - 1.1e-92 310.0 5.0 1.1e-92 310.0 5.0 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase V-ATPase_G PF03179.13 NM_133262.2_2 - 4.6e-36 123.4 9.7 6e-36 123.0 9.7 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.6 NM_133262.2_2 - 0.0062 15.8 7.4 0.0079 15.5 7.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) ATP-synt_B PF00430.16 NM_133262.2_2 - 0.011 15.7 6.7 0.014 15.3 6.7 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) FdhE PF04216.10 NM_133262.2_2 - 0.11 12.1 2.9 0.14 11.8 2.9 1.1 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation OmpH PF03938.12 NM_133262.2_2 - 0.22 11.4 10.5 0.29 11.0 10.5 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Muted PF14942.4 NM_133262.2_2 - 0.77 9.9 12.7 1.4 9.1 12.7 1.4 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF883 PF05957.11 NM_133262.2_2 - 0.95 9.9 5.4 4 8.0 4.8 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) AMP-binding PF00501.26 NM_001288970.1_3 - 1.7e-75 254.1 0.1 8.7e-74 248.5 0.0 2.0 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.4 NM_001288970.1_3 - 2.4e-17 63.5 0.1 6.5e-17 62.1 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Gelsolin PF00626.20 NM_001256139.1_3 - 8.2e-59 195.3 0.0 9e-20 70.2 0.0 3.2 3 0 0 3 3 3 3 Gelsolin repeat Annexin PF00191.18 NM_003568.2_3 - 9.2e-70 230.5 0.5 9.2e-17 60.8 0.1 4.2 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.3 NM_003568.2_3 - 0.03 14.1 0.0 19 5.1 0.1 3.2 2 1 1 3 3 3 0 Myb DNA-binding like T4_tail_cap PF11091.6 NM_003568.2_3 - 0.037 12.8 0.0 0.072 11.9 0.0 1.5 1 0 0 1 1 1 0 Tail-tube assembly protein HTH_34 PF13601.4 NM_003568.2_3 - 0.12 12.4 0.1 0.31 11.1 0.1 1.7 1 0 0 1 1 1 0 Winged helix DNA-binding domain FIIND PF13553.4 NM_001184901.1_3 - 3.7e-91 304.8 0.0 4.8e-91 304.4 0.0 1.1 1 0 0 1 1 1 1 Function to find CARD PF00619.19 NM_001184901.1_3 - 5.3e-19 67.9 2.0 8.5e-19 67.3 2.0 1.3 1 0 0 1 1 1 1 Caspase recruitment domain Dermcidin PF15291.4 NM_053283.3_2 - 1.9e-44 150.2 4.2 2.7e-44 149.7 4.2 1.1 1 0 0 1 1 1 1 Dermcidin, antibiotic peptide CTNNB1_binding PF08347.9 NM_001146285.1_1 - 2.8e-100 334.4 3.3 2.8e-100 334.4 3.3 2.2 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 NM_001146285.1_1 - 1.7e-21 76.3 1.0 1.7e-21 76.3 1.0 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_001146285.1_1 - 7.6e-08 32.7 2.0 1.6e-07 31.7 2.0 1.5 1 0 0 1 1 1 1 HMG-box domain Rad60-SLD PF11976.6 NM_001286416.1_3 - 3e-19 68.5 1.0 4.1e-09 36.0 0.3 2.2 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 NM_001286416.1_3 - 8e-06 25.4 0.1 0.0024 17.4 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin family DUF1077 PF06417.10 NM_016454.3_2 - 1.6e-45 153.8 3.5 2.2e-45 153.3 3.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Pkinase PF00069.23 NM_052827.3_1 - 5.2e-55 186.5 0.0 7.4e-47 159.8 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_052827.3_1 - 1.8e-27 96.1 0.0 2.6e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_052827.3_1 - 0.064 13.0 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_052827.3_1 - 0.13 11.4 0.1 3.8 6.6 0.0 2.6 3 0 0 3 3 3 0 Kinase-like SYF2 PF08231.10 NM_015484.4_2 - 7.6e-55 185.5 11.5 7.6e-55 185.5 11.5 1.8 2 0 0 2 2 2 1 SYF2 splicing factor tRNA_SAD PF07973.12 NM_015484.4_2 - 0.081 12.9 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Threonyl and Alanyl tRNA synthetase second additional domain DUF4097 PF13349.4 NM_001145268.1_2 - 3.9e-09 36.1 15.0 3.3e-06 26.5 15.0 2.1 1 1 0 1 1 1 1 Putative adhesin TMEM71 PF15121.4 NM_001145268.1_2 - 0.006 16.1 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 TMEM71 protein family DUF2807 PF10988.6 NM_001145268.1_2 - 0.0065 16.1 0.7 0.0065 16.1 0.7 2.1 2 0 0 2 2 2 1 Putative auto-transporter adhesin, head GIN domain Myosin_N PF02736.17 NM_001145268.1_2 - 0.02 14.6 7.0 4.7 7.0 0.2 3.9 2 1 1 3 3 3 0 Myosin N-terminal SH3-like domain DUF2642 PF10842.6 NM_001145268.1_2 - 0.25 11.1 1.5 2 8.2 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2642) PUMA PF15826.3 NM_001127242.2_1 - 2.4e-20 73.4 1.8 4.9e-20 72.4 1.8 1.5 1 0 0 1 1 1 1 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis ATP-grasp_2 PF08442.8 NM_003848.3_2 - 4.1e-77 258.2 0.7 6.5e-77 257.5 0.7 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.17 NM_003848.3_2 - 9.1e-27 93.6 0.3 1.9e-26 92.6 0.3 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.4 NM_003848.3_2 - 3.4e-09 36.4 0.3 6.6e-09 35.4 0.1 1.5 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.17 NM_003848.3_2 - 0.0031 17.2 0.0 0.0053 16.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Tropomyosin PF00261.18 NM_001018008.1_2 - 6.2e-88 294.0 60.6 6.2e-88 294.0 60.6 1.3 2 0 0 2 2 2 1 Tropomyosin Tropomyosin_1 PF12718.5 NM_001018008.1_2 - 8.1e-23 81.0 55.6 1.8e-19 70.1 25.2 3.0 1 1 0 2 2 2 2 Tropomyosin like Laminin_II PF06009.10 NM_001018008.1_2 - 3.9e-05 23.5 7.8 3.9e-05 23.5 7.8 3.6 1 1 1 3 3 3 1 Laminin Domain II Alanine_zipper PF11839.6 NM_001018008.1_2 - 0.052 13.7 30.7 0.12 12.5 2.9 4.1 1 1 2 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein XhlA PF10779.7 NM_001018008.1_2 - 0.12 12.4 34.5 0.058 13.4 3.0 4.9 3 1 2 5 5 5 0 Haemolysin XhlA DUF1664 PF07889.10 NM_001018008.1_2 - 0.18 11.7 23.1 0.16 11.8 2.7 3.3 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) ADIP PF11559.6 NM_001018008.1_2 - 0.24 11.3 42.6 0.051 13.5 9.2 3.7 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding AAA_13 PF13166.4 NM_001018008.1_2 - 0.24 9.9 34.0 0.13 10.8 31.9 1.4 1 1 0 1 1 1 0 AAA domain Baculo_PEP_C PF04513.10 NM_001018008.1_2 - 1.1 9.2 9.9 1.3 8.9 2.5 2.8 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF745 PF05335.11 NM_001018008.1_2 - 1.3 8.5 36.7 1.7 8.3 22.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Lebercilin PF15619.4 NM_001018008.1_2 - 1.8 8.0 51.5 3.4 7.2 12.4 2.9 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease TMF_DNA_bd PF12329.6 NM_001018008.1_2 - 1.9 8.4 45.7 0.058 13.3 12.8 5.3 1 1 3 5 5 5 0 TATA element modulatory factor 1 DNA binding Cep57_CLD PF14073.4 NM_001018008.1_2 - 2.3 8.1 47.6 0.66 9.8 22.3 2.9 1 1 1 2 2 2 0 Centrosome localisation domain of Cep57 CENP-F_leu_zip PF10473.7 NM_001018008.1_2 - 2.3 8.1 51.8 0.22 11.4 31.3 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.8 NM_001018008.1_2 - 3.7 7.6 24.8 0.31 11.1 8.4 2.8 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Snapin_Pallidin PF14712.4 NM_001018008.1_2 - 4 7.8 24.2 1.2 9.4 4.5 4.5 1 1 3 5 5 5 0 Snapin/Pallidin FH2 PF02181.21 NM_001018008.1_2 - 4 6.3 26.4 1.4 7.9 4.0 2.8 1 1 2 3 3 3 0 Formin Homology 2 Domain BST2 PF16716.3 NM_001018008.1_2 - 4.1 7.9 35.0 5 7.6 4.1 3.8 1 1 3 4 4 4 0 Bone marrow stromal antigen 2 CENP-Q PF13094.4 NM_001018008.1_2 - 4.4 7.3 48.2 0.43 10.6 17.5 3.2 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit TMPIT PF07851.11 NM_001018008.1_2 - 4.5 6.3 29.4 0.23 10.5 9.8 2.7 1 1 1 2 2 2 0 TMPIT-like protein CLZ PF16526.3 NM_001018008.1_2 - 6.8 7.0 34.7 2.3 8.5 4.2 4.4 3 2 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF16 PF01519.14 NM_001018008.1_2 - 7.7 6.9 32.5 2.5 8.5 6.9 4.0 1 1 3 4 4 4 0 Protein of unknown function DUF16 DUF3584 PF12128.6 NM_001018008.1_2 - 8 3.7 46.1 4.7 4.4 28.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) NPV_P10 PF05531.10 NM_001018008.1_2 - 8.1 6.9 12.3 53 4.2 0.4 4.1 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein GAS PF13851.4 NM_001018008.1_2 - 8.6 5.5 45.8 1.8 7.7 17.0 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding SPRY PF00622.26 NM_001319670.1_1 - 3e-19 69.2 0.0 4.1e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 SPRY domain SOCS_box PF07525.14 NM_001319670.1_1 - 2.5e-11 43.6 2.8 2.5e-11 43.6 2.8 1.7 2 0 0 2 2 2 1 SOCS box GST_N_3 PF13417.4 NM_183239.1_2 - 1.5e-17 63.6 0.1 2.7e-17 62.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 NM_183239.1_2 - 4.5e-12 46.0 0.1 8.8e-12 45.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 NM_183239.1_2 - 5.8e-12 45.6 0.1 1.4e-11 44.4 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 NM_183239.1_2 - 2.8e-06 27.1 0.0 5.5e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.22 NM_183239.1_2 - 0.00032 20.7 0.0 0.00092 19.3 0.0 1.8 1 0 0 1 1 1 1 Glutaredoxin GST_C PF00043.23 NM_183239.1_2 - 0.0066 16.5 0.8 0.017 15.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_183239.1_2 - 0.01 15.9 0.0 0.024 14.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Pyridoxal_deC PF00282.17 NM_001244705.1_2 - 3.3e-110 368.2 0.0 4e-110 367.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 NM_001244705.1_2 - 1.3e-05 24.2 0.0 2.2e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 NM_001244705.1_2 - 0.00022 20.5 0.0 0.00031 20.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.11 NM_001244705.1_2 - 0.2 10.2 0.0 0.3 9.6 0.0 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Lamp PF01299.15 NM_001122606.1_1 - 4.5e-116 387.7 9.4 3e-114 381.7 5.7 2.1 2 0 0 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.10 NM_001122606.1_1 - 3e-10 39.9 2.6 7.6e-08 32.2 0.5 2.4 2 0 0 2 2 2 2 Vacuolar ATP synthase subunit S1 (ATP6S1) Pkinase PF00069.23 NM_145862.2_1 - 1.4e-52 178.5 0.1 4.7e-29 101.4 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_145862.2_1 - 1e-16 60.9 0.0 4.4e-09 35.9 0.1 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase FHA PF00498.24 NM_145862.2_1 - 7.3e-12 45.3 0.0 1.8e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 FHA domain RAP1 PF07218.9 NM_145862.2_1 - 3.4 5.7 6.6 4.8 5.2 6.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4698 PF15769.3 NM_145862.2_1 - 9.7 5.0 7.5 16 4.2 7.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) TRPM_tetra PF16519.3 NM_206946.3_2 - 5.6e-24 83.9 5.4 1.1e-23 82.9 5.4 1.6 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.29 NM_206946.3_2 - 5.1e-18 65.1 17.7 7.8e-18 64.5 17.7 1.3 1 0 0 1 1 1 1 Ion transport protein DUF3552 PF12072.6 NM_206946.3_2 - 0.028 13.7 4.3 0.071 12.4 4.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Reo_sigmaC PF04582.10 NM_206946.3_2 - 0.08 12.2 0.4 0.15 11.3 0.4 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein ANAPC4_WD40 PF12894.5 NM_152623.2_1 - 4e-14 52.5 3.4 0.00066 19.8 0.4 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 NM_152623.2_1 - 2.4e-10 40.7 15.5 0.00014 22.4 0.5 5.8 5 1 1 6 6 6 3 WD domain, G-beta repeat CBS PF00571.26 NM_017623.4_1 - 9.2e-07 29.1 0.2 0.0013 19.0 0.0 2.5 2 0 0 2 2 2 2 CBS domain DUF21 PF01595.18 NM_017623.4_1 - 1.1e-05 25.0 5.0 2.8e-05 23.7 5.0 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF21 cNMP_binding PF00027.27 NM_017623.4_1 - 0.064 13.1 0.1 0.44 10.5 0.0 2.2 2 0 0 2 2 2 0 Cyclic nucleotide-binding domain MIP PF00230.18 NM_001320635.1_2 - 2.1e-27 96.2 5.8 3.2e-27 95.6 5.8 1.1 1 0 0 1 1 1 1 Major intrinsic protein MIP PF00230.18 NM_001320635.1_3 - 0.0021 17.7 1.2 0.0031 17.1 1.2 1.2 1 0 0 1 1 1 1 Major intrinsic protein TACC PF05010.12 NM_001291878.1_2 - 2.7e-84 281.8 34.2 3.9e-84 281.3 34.2 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) Skp1_POZ PF03931.13 NM_001291878.1_2 - 0.016 15.3 1.0 0.053 13.6 0.4 2.1 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain DUF4483 PF14825.4 NM_001100159.2_3 - 0.0023 17.6 1.2 0.0055 16.3 0.4 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4483) Ets PF00178.20 NM_003120.2_2 - 1.3e-22 79.9 2.4 2.1e-22 79.3 2.4 1.3 1 0 0 1 1 1 1 Ets-domain TGS PF02824.19 NM_080794.3_3 - 0.0011 18.9 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 TGS domain DUF2469 PF10611.7 NM_080794.3_3 - 0.05 14.0 0.0 1.2 9.6 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2469) DUF846 PF05832.10 NM_001204478.1_1 - 2.2e-44 150.7 8.3 3.2e-44 150.2 8.3 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) CDRT4 PF15213.4 NM_001204478.1_3 - 1.3e-69 233.0 1.9 1.8e-69 232.5 1.9 1.3 1 0 0 1 1 1 1 CMT1A duplicated region transcript 4 protein zf-H2C2_2 PF13465.4 NM_001324348.1_1 - 6.1e-60 197.0 74.6 3.4e-08 33.4 0.5 10.5 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001324348.1_1 - 8.2e-51 167.6 70.1 5.6e-06 26.4 1.1 10.2 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001324348.1_1 - 7.7e-27 91.5 64.5 0.0044 17.6 0.4 10.3 10 0 0 10 10 10 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001324348.1_1 - 3.8e-08 33.2 51.7 0.0045 16.9 2.8 7.5 5 4 5 10 10 9 6 Zinc ribbon domain C1_4 PF07975.10 NM_001324348.1_1 - 6.3e-08 32.6 34.4 0.43 10.7 0.6 8.4 1 1 8 9 9 9 7 TFIIH C1-like domain zf-C2H2_6 PF13912.4 NM_001324348.1_1 - 2.1e-07 30.6 42.8 1.4 8.8 0.2 9.6 9 0 0 9 9 9 6 C2H2-type zinc finger XPA_N PF01286.16 NM_001324348.1_1 - 6.1e-07 29.2 42.5 2.4 8.1 0.4 9.8 10 0 0 10 10 10 4 XPA protein N-terminal CpXC PF14353.4 NM_001324348.1_1 - 3.8e-06 26.8 27.5 2.3 8.1 0.1 9.2 4 2 4 10 10 10 2 CpXC protein zf-C2HC_2 PF13913.4 NM_001324348.1_1 - 2.5e-05 23.9 23.6 1.2 9.0 0.0 7.9 7 0 0 7 7 7 3 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 NM_001324348.1_1 - 0.0014 18.7 24.5 6.7 7.0 0.0 8.3 9 0 0 9 9 8 2 Zinc-finger double-stranded RNA-binding Pectate_lyase22 PF14583.4 NM_001324348.1_1 - 0.018 13.6 0.0 0.047 12.2 0.0 1.6 2 0 0 2 2 2 0 Oligogalacturonate lyase zinc_ribbon_15 PF17032.3 NM_001324348.1_1 - 0.084 13.5 43.9 0.52 11.0 4.1 6.3 2 2 3 7 7 7 0 zinc-ribbon family DUF3268 PF11672.6 NM_001324348.1_1 - 0.12 12.6 30.5 1.1 9.5 1.1 5.2 1 1 8 9 9 9 0 zinc-finger-containing domain zf-C2H2_11 PF16622.3 NM_001324348.1_1 - 0.16 11.6 49.4 0.48 10.1 0.2 9.5 9 0 0 9 9 9 0 zinc-finger C2H2-type HypA PF01155.17 NM_001324348.1_1 - 0.19 11.6 34.1 5 7.0 1.9 5.8 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA GAGA PF09237.9 NM_001324348.1_1 - 1.3 8.7 4.7 32 4.3 0.0 4.2 2 1 1 4 4 4 0 GAGA factor zf-trcl PF13451.4 NM_001324348.1_1 - 3.9 7.3 29.7 12 5.7 0.1 8.6 9 0 0 9 9 9 0 Probable zinc-ribbon domain RRM_1 PF00076.20 NM_001243879.1_2 - 7.2e-21 73.7 0.0 1.1e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NHL PF01436.19 NM_001099679.1_3 - 3.7e-33 111.8 0.6 1.8e-06 27.6 0.0 6.4 6 0 0 6 6 6 5 NHL repeat zf-RING_UBOX PF13445.4 NM_001099679.1_3 - 6.9e-11 41.8 6.3 6.9e-11 41.8 6.3 2.8 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_001099679.1_3 - 3.2e-09 36.8 8.2 3.2e-09 36.8 8.2 3.3 3 0 0 3 3 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_001099679.1_3 - 3.5e-07 29.9 7.8 3.5e-07 29.9 7.8 3.4 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.23 NM_001099679.1_3 - 4.1e-07 29.6 8.6 4.1e-07 29.6 8.6 3.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_001099679.1_3 - 6.9e-05 22.8 8.2 6.9e-05 22.8 8.2 3.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 NM_001099679.1_3 - 0.00011 21.8 8.5 0.00011 21.8 8.5 3.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.9 NM_001099679.1_3 - 0.00015 21.6 0.4 0.00043 20.1 0.4 1.7 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.4 NM_001099679.1_3 - 0.00021 20.8 5.1 0.00021 20.8 5.1 2.7 2 0 0 2 2 1 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.4 NM_001099679.1_3 - 0.00052 19.7 8.4 0.00052 19.7 8.4 3.6 3 1 1 4 4 3 1 Prokaryotic RING finger family 4 zf-B_box PF00643.22 NM_001099679.1_3 - 0.00053 20.0 3.4 0.00053 20.0 3.4 3.3 2 0 0 2 2 2 1 B-box zinc finger SGL PF08450.10 NM_001099679.1_3 - 0.002 17.6 0.0 24 4.2 0.0 3.8 2 1 2 4 4 4 0 SMP-30/Gluconolaconase/LRE-like region FYVE PF01363.19 NM_001099679.1_3 - 0.0099 15.9 19.4 1.2 9.2 8.9 2.9 1 1 1 2 2 2 2 FYVE zinc finger zf-RING_11 PF17123.3 NM_001099679.1_3 - 0.013 15.1 5.6 0.037 13.6 5.6 1.9 1 0 0 1 1 1 0 RING-like zinc finger IBR PF01485.19 NM_001099679.1_3 - 9.4 6.4 12.5 0.8 9.8 1.7 3.5 2 1 1 3 3 2 0 IBR domain, a half RING-finger domain PPR_2 PF13041.4 NM_001198879.1_1 - 7.4e-32 109.2 1.3 5.9e-12 45.5 0.1 8.7 5 3 4 9 9 9 8 PPR repeat family PPR_3 PF13812.4 NM_001198879.1_1 - 3e-22 78.3 1.4 0.00024 21.0 0.0 5.5 4 1 1 5 5 5 5 Pentatricopeptide repeat domain PPR_long PF17177.2 NM_001198879.1_1 - 3.1e-16 59.3 0.1 3.2e-12 46.1 0.0 3.1 2 1 1 3 3 3 2 Pentacotripeptide-repeat region of PROPR PPR PF01535.18 NM_001198879.1_1 - 1.2e-12 47.1 7.9 2.5e-05 24.1 0.1 7.0 8 0 0 8 8 8 2 PPR repeat PPR_1 PF12854.5 NM_001198879.1_1 - 1.7e-05 24.3 2.9 0.0043 16.6 0.0 4.7 4 0 0 4 4 4 1 PPR repeat WRW PF10206.7 NM_001198879.1_1 - 9.6e-05 22.6 0.0 0.00019 21.6 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f MNE1 PF13762.4 NM_001198879.1_1 - 0.55 10.1 2.7 1.2 9.0 0.4 2.4 2 1 1 3 3 3 0 Mitochondrial splicing apparatus component Rapsyn_N PF10579.7 NM_032645.4_2 - 2.6e-41 139.4 0.9 8.2e-41 137.9 0.7 1.9 2 0 0 2 2 2 1 Rapsyn N-terminal myristoylation and linker region TPR_12 PF13424.4 NM_032645.4_2 - 3.5e-12 46.3 4.8 0.00023 21.2 0.6 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.26 NM_032645.4_2 - 1.2e-11 43.7 13.3 0.023 14.4 0.1 6.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.15 NM_032645.4_2 - 3.5e-11 42.2 1.9 0.14 12.2 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_032645.4_2 - 4.2e-10 38.9 2.9 0.058 13.5 0.1 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_032645.4_2 - 1.2e-08 34.3 2.7 3.4 7.8 0.0 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat zf-RING_2 PF13639.4 NM_032645.4_2 - 8e-08 32.3 4.2 8e-08 32.3 4.2 3.1 4 0 0 4 4 3 1 Ring finger domain zf-RING_11 PF17123.3 NM_032645.4_2 - 6e-06 25.7 1.2 6e-06 25.7 1.2 2.5 3 0 0 3 3 2 1 RING-like zinc finger zf-RING_5 PF14634.4 NM_032645.4_2 - 5e-05 23.1 5.1 5e-05 23.1 5.1 2.8 3 0 0 3 3 3 1 zinc-RING finger domain TPR_11 PF13414.4 NM_032645.4_2 - 0.00013 21.5 0.0 1 9.0 0.0 3.9 5 0 0 5 5 5 2 TPR repeat TPR_10 PF13374.4 NM_032645.4_2 - 0.00093 18.9 5.3 0.043 13.6 0.3 5.0 6 0 0 6 6 5 1 Tetratricopeptide repeat Prok-RING_4 PF14447.4 NM_032645.4_2 - 0.00094 18.9 6.0 0.00094 18.9 6.0 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.4 NM_032645.4_2 - 0.001 18.9 4.7 0.0069 16.2 3.3 2.7 2 0 0 2 2 2 1 RING-type zinc-finger DUF3856 PF12968.5 NM_032645.4_2 - 0.0038 17.2 0.9 0.65 9.9 0.1 3.3 2 1 1 3 3 3 1 Domain of Unknown Function (DUF3856) zf-RING_4 PF14570.4 NM_032645.4_2 - 0.014 15.0 4.8 0.052 13.1 2.1 2.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.23 NM_032645.4_2 - 0.016 15.0 4.2 0.016 15.0 4.2 2.8 4 0 0 4 4 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_032645.4_2 - 0.018 15.2 4.7 0.059 13.5 4.7 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain TPR_19 PF14559.4 NM_032645.4_2 - 0.028 14.8 1.3 13 6.3 0.0 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_032645.4_2 - 0.12 12.9 3.5 39 5.0 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat Cys_rich_CPXG PF14255.4 NM_032645.4_2 - 0.24 11.2 0.1 0.24 11.2 0.1 2.6 3 0 0 3 3 3 0 Cysteine-rich CPXCG ANAPC3 PF12895.5 NM_032645.4_2 - 0.26 11.4 7.6 10 6.3 1.2 3.6 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-HC5HC2H_2 PF13832.4 NM_032645.4_2 - 8.2 6.5 9.7 1.3 9.1 5.2 2.0 2 0 0 2 2 2 0 PHD-zinc-finger like domain zf-NF-X1 PF01422.15 NM_006350.3_1 - 0.045 13.7 7.7 0.16 11.9 7.7 2.0 1 0 0 1 1 1 0 NF-X1 type zinc finger Kazal_2 PF07648.13 NM_006350.3_2 - 7.8e-32 109.1 38.5 7.1e-13 48.4 1.4 4.9 5 0 0 5 5 5 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 NM_006350.3_2 - 1.5e-17 63.2 39.0 1e-06 28.5 5.0 4.3 4 0 0 4 4 4 3 Kazal-type serine protease inhibitor domain FOLN PF09289.8 NM_006350.3_2 - 1.1e-06 28.6 12.7 1.1e-06 28.6 12.7 4.1 3 0 0 3 3 3 1 Follistatin/Osteonectin-like EGF domain CRAL_TRIO PF00650.18 NM_000326.4_3 - 7.4e-36 123.1 0.1 1.1e-35 122.6 0.1 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.4 NM_000326.4_3 - 1.1e-10 41.6 0.0 1.6e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.13 NM_000326.4_3 - 4.9e-06 26.5 0.3 1.4e-05 25.1 0.3 1.8 1 1 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF1266 PF06889.9 NM_000326.4_3 - 0.17 11.8 0.2 0.26 11.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) MAPEG PF01124.16 NM_001204367.1_3 - 2.6e-11 43.4 1.3 4e-11 42.8 1.3 1.2 1 0 0 1 1 1 1 MAPEG family GREB1 PF15782.3 NM_148903.2_2 - 1e-165 553.4 0.0 1.3e-165 553.1 0.0 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer Pox_A3L PF05288.9 NM_148903.2_2 - 0.074 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A3L Protein LRR_8 PF13855.4 NM_024416.4_1 - 1.5e-16 59.8 6.8 9.3e-09 34.8 0.2 3.9 3 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_024416.4_1 - 1.2e-08 34.9 12.1 9.7e-05 22.5 1.7 4.2 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_024416.4_1 - 0.084 13.3 11.6 6.3 7.6 0.0 5.9 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.4 NM_024416.4_1 - 9.7 6.4 6.0 32 4.8 0.0 4.1 5 0 0 5 5 5 0 Leucine Rich repeat MutS_V PF00488.19 NM_002439.4_3 - 4.7e-72 241.9 0.5 3.1e-71 239.2 0.1 2.3 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.16 NM_002439.4_3 - 4.3e-37 128.0 0.0 4.3e-37 128.0 0.0 2.2 2 2 0 2 2 2 1 MutS domain III MutS_II PF05188.15 NM_002439.4_3 - 1.2e-33 116.2 0.2 1.2e-33 116.2 0.2 2.1 2 0 0 2 2 2 1 MutS domain II MutS_I PF01624.18 NM_002439.4_3 - 6.9e-32 109.9 0.0 1.3e-31 109.0 0.0 1.5 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.16 NM_002439.4_3 - 0.011 15.9 0.0 0.035 14.3 0.0 1.9 1 0 0 1 1 1 0 MutS family domain IV NPV_P10 PF05531.10 NM_002439.4_3 - 0.14 12.5 0.4 20 5.6 0.0 2.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Cyclin_N PF00134.21 NM_181698.3_1 - 6.3e-14 51.7 0.2 9.7e-14 51.1 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.9 NM_181698.3_1 - 1.5e-10 41.5 0.1 1.5e-10 41.5 0.1 1.9 2 0 0 2 2 2 1 Cyclin DMAP_binding PF06464.9 NM_206891.2_1 - 4.4e-36 123.9 1.0 7.2e-36 123.2 1.0 1.4 1 0 0 1 1 1 1 DMAP1-binding Domain AMP-binding PF00501.26 NM_206891.2_1 - 6.2e-24 84.2 0.1 1.7e-23 82.7 0.1 1.6 1 1 0 1 1 1 1 AMP-binding enzyme GvpG PF05120.10 NM_206891.2_1 - 0.00093 19.0 0.1 0.0017 18.2 0.1 1.4 1 0 0 1 1 1 1 Gas vesicle protein G GSAP-16 PF14959.4 NM_017439.3_2 - 8.6e-39 131.6 0.2 2.1e-38 130.4 0.2 1.7 1 0 0 1 1 1 1 gamma-Secretase-activating protein C-term Ank_2 PF12796.5 NM_006663.3_3 - 4.4e-15 55.9 1.3 4.5e-11 43.0 0.2 1.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) SH3_9 PF14604.4 NM_006663.3_3 - 1.5e-11 43.8 0.7 2.9e-11 42.9 0.7 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.28 NM_006663.3_3 - 6.7e-10 38.8 2.4 0.00054 20.2 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat SH3_1 PF00018.26 NM_006663.3_3 - 1.1e-09 37.6 0.5 1.9e-09 36.8 0.5 1.4 1 0 0 1 1 1 1 SH3 domain Ank_3 PF13606.4 NM_006663.3_3 - 1.2e-08 34.4 1.0 0.0071 16.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 NM_006663.3_3 - 3.5e-08 33.5 1.5 9.4e-05 22.6 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_2 PF07653.15 NM_006663.3_3 - 1.6e-07 30.8 0.0 3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Ank_4 PF13637.4 NM_006663.3_3 - 1.9e-07 31.4 0.2 0.0014 19.0 0.2 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) LRR_4 PF12799.5 NM_001291381.1_2 - 0.1 12.9 8.7 1.7 9.0 0.3 4.9 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) Ribosomal_L22e PF01776.15 NM_001099645.1_3 - 2e-47 159.9 3.1 3.1e-47 159.3 3.1 1.3 1 0 0 1 1 1 1 Ribosomal L22e protein family CamS PF07537.9 NM_001099645.1_3 - 0.088 11.8 0.5 0.12 11.4 0.5 1.1 1 0 0 1 1 1 0 CamS sex pheromone cAM373 precursor HlyIII PF03006.18 NM_001284512.1_2 - 4.8e-10 39.4 0.4 1.6e-08 34.4 0.0 2.2 1 1 1 2 2 2 2 Haemolysin-III related UPF0542 PF15086.4 NM_001048249.3_2 - 1.6e-30 104.7 2.9 3e-30 103.8 2.9 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0542 Transposase_22 PF02994.12 NM_001164835.1_1 - 1.3e-79 267.6 18.0 7.9e-61 205.8 14.2 3.6 3 1 1 4 4 4 2 L1 transposable element HSBP1 PF06825.10 NM_001164835.1_1 - 0.045 13.6 2.9 0.2 11.5 2.9 2.1 1 0 0 1 1 1 0 Heat shock factor binding protein 1 PDEase_I PF00233.17 NM_001164835.1_1 - 0.086 12.4 4.1 1.2 8.7 1.1 2.6 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase Ribosomal_L10 PF00466.18 NM_145255.3_1 - 8.4e-07 28.9 0.1 1.4e-06 28.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 Filament PF00038.19 NM_170707.3_1 - 2.5e-97 326.1 55.0 3.2e-97 325.8 55.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.17 NM_170707.3_1 - 1.6e-17 63.7 0.0 2.9e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Lamin Tail Domain Fez1 PF06818.13 NM_170707.3_1 - 0.0019 18.5 25.1 0.0019 18.5 25.1 3.2 1 1 1 3 3 3 1 Fez1 Reo_sigmaC PF04582.10 NM_170707.3_1 - 0.0042 16.4 14.3 0.029 13.7 0.6 3.1 1 1 2 3 3 3 3 Reovirus sigma C capsid protein HAUS-augmin3 PF14932.4 NM_170707.3_1 - 0.0051 16.2 6.3 0.0051 16.2 6.3 3.7 1 1 2 3 3 2 1 HAUS augmin-like complex subunit 3 TPR_MLP1_2 PF07926.10 NM_170707.3_1 - 0.0058 16.6 59.0 0.34 10.8 7.1 4.1 1 1 2 4 4 4 4 TPR/MLP1/MLP2-like protein IncA PF04156.12 NM_170707.3_1 - 0.085 12.5 69.4 0.014 15.0 12.0 3.9 1 1 3 4 4 3 0 IncA protein Tht1 PF04163.10 NM_170707.3_1 - 0.41 9.2 7.5 0.6 8.7 7.5 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein CENP-F_leu_zip PF10473.7 NM_170707.3_1 - 0.88 9.5 56.6 1 9.2 12.1 3.4 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.9 NM_170707.3_1 - 2.3 6.9 52.3 8.1 5.1 22.9 3.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF3584 PF12128.6 NM_170707.3_1 - 6 4.1 51.2 16 2.7 51.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4113 PF13438.4 NM_170707.3_2 - 0.28 11.2 4.2 0.29 11.1 0.9 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4113) RhoGEF PF00621.18 NM_015320.3_1 - 5.3e-46 157.0 3.6 8.3e-46 156.4 3.6 1.3 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 NM_015320.3_1 - 2.4e-10 39.7 1.9 4e-10 39.0 1.9 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_015320.3_1 - 2e-08 33.6 0.0 4.2e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 NM_015320.3_1 - 2.3e-08 34.3 0.0 5.4e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.4 NM_015320.3_1 - 2.1e-07 30.5 0.2 3.8e-07 29.7 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF4477 PF14780.4 NM_015412.3_2 - 1.9e-65 219.9 4.7 3.1e-65 219.2 4.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) OB_NTP_bind PF07717.14 NM_024612.4_1 - 3.6e-18 65.6 0.0 8.2e-18 64.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 NM_024612.4_1 - 8.1e-15 54.9 0.0 8.1e-15 54.9 0.0 1.8 2 0 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 NM_024612.4_1 - 1.7e-10 41.1 0.0 7.1e-10 39.1 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.27 NM_024612.4_1 - 8.4e-09 35.3 0.2 1.6e-08 34.4 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.18 NM_024612.4_1 - 3.7e-05 22.8 0.0 7.6e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.4 NM_024612.4_1 - 6.6e-05 23.1 0.0 0.00016 21.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.4 NM_024612.4_1 - 0.00012 21.7 0.4 0.00032 20.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.7 NM_024612.4_1 - 0.00014 21.1 0.0 0.00024 20.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DUF4685 PF15737.3 NM_024612.4_1 - 0.0018 18.6 1.2 0.51 10.7 1.5 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4685) AAA_19 PF13245.4 NM_024612.4_1 - 0.0037 17.5 0.0 0.0069 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.12 NM_024612.4_1 - 0.03 14.2 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain Helicase_RecD PF05127.12 NM_024612.4_1 - 0.092 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Helicase PhoH PF02562.14 NM_024612.4_1 - 0.14 11.4 0.1 0.4 10.0 0.1 1.6 2 0 0 2 2 2 0 PhoH-like protein ARID PF01388.19 NM_001319094.1_1 - 1.7e-13 50.9 0.0 2.8e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain IQ PF00612.25 NM_014984.3_2 - 0.073 12.8 1.8 0.53 10.1 1.8 2.6 1 0 0 1 1 1 0 IQ calmodulin-binding motif UCR_hinge PF02320.14 NM_014984.3_2 - 0.15 12.2 3.0 0.67 10.1 3.0 2.2 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein DUF826 PF05696.9 NM_014984.3_2 - 4 7.5 7.0 1.3 9.1 1.4 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF826) Lactamase_B_4 PF13691.4 NM_001165962.1_1 - 1.9e-16 59.4 0.0 4.9e-16 58.0 0.0 1.8 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.5 NM_001165962.1_1 - 1.3e-14 54.1 0.1 1e-11 44.6 0.6 2.9 3 1 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.25 NM_001165962.1_1 - 0.00097 19.1 0.6 0.0033 17.3 0.3 2.0 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily GOLGA2L5 PF15070.4 NM_001267536.2_3 - 1.1e-16 60.6 19.3 1.1e-16 60.6 19.3 4.3 1 1 2 3 3 3 1 Putative golgin subfamily A member 2-like protein 5 Rhodanese PF00581.18 NM_001013436.2_2 - 1.4e-26 92.9 0.0 6.2e-14 52.3 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain B12D PF06522.9 NM_001013436.2_2 - 0.13 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit CARD PF00619.19 NM_001320100.1_1 - 5.5e-15 55.0 0.1 7.7e-15 54.6 0.1 1.2 1 0 0 1 1 1 1 Caspase recruitment domain Exo70 PF03081.13 NM_001145299.3_3 - 3.8e-77 259.8 3.0 3.8e-77 259.8 3.0 1.5 2 0 0 2 2 2 1 Exo70 exocyst complex subunit COG5 PF10392.7 NM_001145299.3_3 - 0.015 15.3 3.4 0.046 13.8 3.4 1.8 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Vps52 PF04129.10 NM_001145299.3_3 - 0.027 13.1 6.7 0.061 11.9 1.0 2.2 2 0 0 2 2 2 0 Vps52 / Sac2 family RolB_RolC PF02027.15 NM_001145299.3_3 - 0.16 11.5 0.2 0.34 10.4 0.2 1.5 1 0 0 1 1 1 0 RolB/RolC glucosidase family Histone_H2A_C PF16211.3 NM_201516.2_2 - 0.00054 19.5 0.4 0.00087 18.9 0.4 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 NM_201516.2_3 - 1.1e-05 25.8 0.0 1.7e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 EF-hand_2 PF09068.9 NM_004019.2_1 - 2.2e-41 140.7 1.3 3.6e-41 140.0 1.3 1.3 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.9 NM_004019.2_1 - 5.5e-40 135.6 0.0 1e-39 134.7 0.0 1.5 1 0 0 1 1 1 1 EF-hand ZZ PF00569.15 NM_004019.2_1 - 6.2e-20 70.6 4.2 1.3e-19 69.5 4.2 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type PAP2 PF01569.19 NM_001135917.1_2 - 1.9e-09 37.3 0.6 1.9e-09 37.3 0.6 1.9 2 0 0 2 2 2 1 PAP2 superfamily ABC2_membrane_3 PF12698.5 NM_001135917.1_2 - 0.35 9.8 2.0 0.52 9.2 2.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein V-set PF07686.15 NM_198153.2_3 - 1.2e-13 51.0 0.3 1.8e-13 50.4 0.3 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 NM_198153.2_3 - 0.054 13.5 0.4 0.31 11.1 0.4 2.0 1 1 0 1 1 1 0 Immunoglobulin domain L27 PF02828.14 NM_001308419.1_3 - 3.4e-17 61.8 0.9 4.1e-17 61.5 0.2 1.5 2 0 0 2 2 2 1 L27 domain CREPT PF16566.3 NM_001308419.1_3 - 0.13 12.3 2.8 0.093 12.8 1.2 1.5 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF3513 PF12026.6 NM_032459.2_3 - 4.2e-51 173.5 0.0 6e-51 173.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3513) zf-LITAF-like PF10601.7 NM_032459.2_3 - 0.0041 17.2 1.2 0.01 16.0 1.2 1.6 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Peptidase_U57 PF05582.10 NM_032459.2_3 - 0.23 10.5 0.1 0.34 10.0 0.1 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Peptidase_M16 PF00675.18 NM_004279.2_2 - 3.5e-56 189.2 0.2 5.5e-56 188.5 0.2 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 NM_004279.2_2 - 1.8e-36 125.7 0.0 1.2e-35 123.0 0.0 2.3 3 0 0 3 3 3 1 Peptidase M16 inactive domain KIF1B PF12423.6 NM_004279.2_2 - 0.099 13.1 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Kinesin protein 1B Ig_3 PF13927.4 NM_018240.6_3 - 2.5e-44 149.6 8.8 6.8e-14 52.1 0.4 5.9 6 0 0 6 6 6 5 Immunoglobulin domain I-set PF07679.14 NM_018240.6_3 - 2.1e-32 110.9 0.1 6.6e-09 35.6 0.0 5.6 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_018240.6_3 - 1.6e-31 108.3 0.1 1.8e-12 47.3 0.1 5.7 4 1 1 5 5 5 5 Immunoglobulin domain ig PF00047.23 NM_018240.6_3 - 9.6e-25 86.4 1.0 1.6e-07 31.2 0.2 5.7 5 1 0 5 5 5 4 Immunoglobulin domain V-set PF07686.15 NM_018240.6_3 - 5.5e-14 52.1 2.6 0.00039 20.4 0.0 6.2 5 2 1 6 6 6 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_018240.6_3 - 1.7e-13 50.3 0.4 3.7e-08 33.2 0.0 4.4 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_018240.6_3 - 1.2e-06 28.7 0.0 0.023 15.0 0.0 4.8 5 0 0 5 5 5 1 Immunoglobulin C1-set domain Ig_5 PF16681.3 NM_018240.6_3 - 3.7e-05 23.9 0.0 0.0098 16.2 0.0 4.4 6 0 0 6 6 6 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 NM_018240.6_3 - 0.011 16.0 0.0 0.18 12.1 0.0 3.0 4 0 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain Metallophos PF00149.26 NM_001142354.2_1 - 5.3e-37 128.2 0.0 7.6e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CENP-T_C PF15511.4 NM_003544.2_1 - 2e-08 34.2 0.1 2.5e-08 33.8 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.15 NM_003544.2_1 - 3.3e-05 23.8 0.2 4.5e-05 23.4 0.2 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.4 NM_003544.2_1 - 6.1e-05 23.2 0.1 8.5e-05 22.7 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.22 NM_003544.2_1 - 0.00027 21.2 0.3 0.00031 21.0 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_003544.2_1 - 0.00037 20.6 0.1 0.00057 20.0 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.13 NM_003544.2_1 - 0.0066 16.4 0.0 0.0078 16.1 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.11 NM_003544.2_1 - 0.03 14.2 0.0 0.048 13.5 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated Stathmin PF00836.17 NM_001199214.1_2 - 9.6e-51 171.2 20.8 1.7e-50 170.4 20.8 1.4 1 0 0 1 1 1 1 Stathmin family LRR_8 PF13855.4 NM_138481.1_3 - 4.2e-93 304.9 18.3 3.3e-12 45.9 0.6 10.2 6 2 5 11 11 11 10 Leucine rich repeat LRR_4 PF12799.5 NM_138481.1_3 - 3.3e-43 144.7 23.3 0.00012 22.2 0.5 12.3 10 2 5 15 15 15 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_138481.1_3 - 1e-12 47.8 0.0 0.062 12.7 0.0 6.1 2 2 4 6 6 6 4 Leucine-rich repeat LRR_1 PF00560.31 NM_138481.1_3 - 3.1e-11 41.9 37.4 28 5.6 0.1 18.1 17 3 1 18 18 18 0 Leucine Rich Repeat LRR_5 PF13306.4 NM_138481.1_3 - 5.6e-06 26.2 0.0 0.018 14.9 0.0 3.3 3 0 0 3 3 3 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 NM_138481.1_3 - 0.00019 20.8 24.6 0.00067 19.1 2.1 4.3 4 0 0 4 4 4 2 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 NM_138481.1_3 - 0.003 17.3 36.8 1.1 9.4 0.2 13.9 19 0 0 19 19 19 2 Leucine Rich repeat LRRCT PF01463.22 NM_138481.1_3 - 0.05 14.0 10.3 0.61 10.6 0.1 4.8 4 0 0 4 4 4 0 Leucine rich repeat C-terminal domain NARP1 PF12569.6 NM_018527.3_1 - 2e-35 122.5 1.6 2e-35 122.5 1.6 3.0 3 1 1 4 4 3 1 NMDA receptor-regulated protein 1 TPR_8 PF13181.4 NM_018527.3_1 - 2.8e-11 42.6 9.1 0.00016 21.5 0.2 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_018527.3_1 - 1.7e-10 40.2 15.0 1.2e-05 24.7 0.6 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.15 NM_018527.3_1 - 2.1e-10 39.8 13.3 2.6e-05 23.9 0.1 5.2 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.4 NM_018527.3_1 - 3e-08 33.1 2.7 4.9e-06 26.0 0.1 3.0 3 0 0 3 3 3 2 TPR repeat TPR_19 PF14559.4 NM_018527.3_1 - 3.4e-08 33.7 3.7 0.015 15.7 0.3 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_018527.3_1 - 7.2e-08 32.5 2.7 0.05 14.3 0.0 5.5 5 1 1 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_018527.3_1 - 1.2e-06 28.4 8.0 0.00019 21.4 0.5 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.4 NM_018527.3_1 - 1.3e-06 27.7 3.0 4.2e-06 26.0 2.5 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 NM_018527.3_1 - 6.3e-06 26.3 5.2 0.73 10.0 0.1 4.9 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_018527.3_1 - 0.00013 21.6 4.2 0.017 15.0 0.1 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_018527.3_1 - 0.00084 19.8 2.7 0.53 10.9 0.0 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_018527.3_1 - 0.0012 19.2 3.7 24 5.7 0.1 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.4 NM_018527.3_1 - 0.0051 16.8 1.3 0.34 11.0 0.2 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_21 PF09976.7 NM_018527.3_1 - 0.009 15.7 0.5 0.32 10.6 0.0 2.7 2 2 1 3 3 3 1 Tetratricopeptide repeat-like domain TPR_10 PF13374.4 NM_018527.3_1 - 0.013 15.2 0.4 17 5.3 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.4 NM_018527.3_1 - 0.018 15.2 2.3 77 3.9 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.10 NM_018527.3_1 - 0.043 13.7 10.7 0.4 10.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.18 NM_018527.3_1 - 0.3 11.3 2.1 11 6.4 0.0 3.5 4 0 0 4 4 3 0 PPR repeat Fis1_TPR_C PF14853.4 NM_018527.3_1 - 1.5 8.8 14.9 5.4 7.0 0.1 4.3 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat NARP1 PF12569.6 NM_018527.3_2 - 2.2e-24 86.1 0.1 2.2e-24 86.1 0.1 2.0 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.15 NM_018527.3_2 - 0.16 12.0 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat GBP_C PF02841.12 NM_002053.2_2 - 6.2e-127 422.9 27.7 7.8e-127 422.6 27.7 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain GBP PF02263.17 NM_002053.2_2 - 1.1e-123 411.5 0.0 1.1e-123 411.5 0.0 3.0 2 1 0 3 3 3 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.21 NM_002053.2_2 - 0.0039 17.1 0.0 0.012 15.5 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase FlgT_C PF16538.3 NM_002053.2_2 - 0.056 13.8 0.3 0.14 12.6 0.3 1.6 1 0 0 1 1 1 0 Flagellar assembly protein T, C-terminal domain zf-NPL4 PF05020.13 NM_002053.2_2 - 0.1 12.6 5.7 4.1 7.4 0.1 2.3 2 0 0 2 2 2 0 NPL4 family, putative zinc binding region Pep_M12B_propep PF01562.17 NM_002053.2_2 - 1.3 9.1 3.7 2.2 8.4 2.6 1.9 2 0 0 2 2 2 0 Reprolysin family propeptide Keratin_B2_2 PF13885.4 NM_198691.2_1 - 3.3e-26 90.8 317.1 3.5e-06 26.7 50.1 8.7 1 1 5 6 6 6 4 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_198691.2_1 - 0.0015 18.4 235.3 1.1 9.1 40.7 5.6 1 1 3 4 4 4 4 Keratin, high sulfur B2 protein Ribosomal_S17_N PF16205.3 NM_001015.4_3 - 7.7e-37 125.4 0.8 7.7e-37 125.4 0.8 1.7 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.18 NM_001015.4_3 - 2.2e-29 101.3 1.7 3.6e-29 100.6 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 PRF PF06875.9 NM_001015.4_3 - 0.16 11.2 0.1 0.26 10.6 0.1 1.2 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF Acetyltransf_1 PF00583.23 NM_001308445.1_3 - 1.9e-12 47.3 0.0 2.9e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 NM_001308445.1_3 - 6.1e-08 32.9 0.1 1.1e-07 32.1 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 NM_001308445.1_3 - 4.4e-07 29.7 0.0 7.1e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.5 NM_001308445.1_3 - 7.6e-05 22.8 0.0 0.00013 22.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 NM_001308445.1_3 - 0.0071 16.2 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.5 NM_001308445.1_3 - 0.074 13.0 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-C2H2 PF00096.24 NM_001002836.3_3 - 3.4e-36 121.6 50.2 4e-07 30.0 2.9 8.8 9 0 0 9 9 8 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001002836.3_3 - 8.7e-34 114.3 42.7 2.6e-09 37.0 0.2 9.3 10 0 0 10 10 10 6 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001002836.3_3 - 4.3e-21 73.6 49.5 0.00045 20.7 1.1 8.9 9 0 0 9 9 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001002836.3_3 - 1.5e-07 31.4 8.9 4.8 7.5 0.1 7.3 7 0 0 7 7 7 1 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.9 NM_001002836.3_3 - 4.5e-07 29.5 13.7 0.66 9.8 0.2 6.7 7 0 0 7 7 7 2 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.4 NM_001002836.3_3 - 4.7e-06 26.3 55.3 0.0024 17.6 0.9 8.5 10 0 0 10 10 8 4 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001002836.3_3 - 7.5e-06 25.8 36.0 0.00026 20.9 0.3 7.4 5 3 4 9 9 9 3 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001002836.3_3 - 8.2e-06 25.4 45.3 0.036 13.7 0.3 8.1 9 0 0 9 9 8 5 zinc-finger C2H2-type ADK_lid PF05191.12 NM_001002836.3_3 - 2.4e-05 24.1 19.4 0.78 9.7 0.9 6.8 5 2 1 6 6 6 2 Adenylate kinase, active site lid zf-Di19 PF05605.10 NM_001002836.3_3 - 0.0013 18.8 0.3 0.0013 18.8 0.3 4.1 4 1 1 5 5 5 1 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.4 NM_001002836.3_3 - 0.0061 16.3 4.6 0.03 14.1 0.7 5.1 6 0 0 6 6 5 2 zinc-finger of a C2HC-type zinc_ribbon_9 PF14369.4 NM_001002836.3_3 - 0.0063 16.6 38.3 2.1 8.5 0.3 8.9 9 0 0 9 9 9 1 zinc-ribbon DZR PF12773.5 NM_001002836.3_3 - 0.013 15.3 36.7 54 3.8 14.4 6.5 3 2 1 4 4 4 0 Double zinc ribbon GAGA PF09237.9 NM_001002836.3_3 - 0.024 14.3 8.7 0.97 9.2 0.1 4.1 3 1 1 4 4 4 0 GAGA factor zf-C2H2_9 PF16293.3 NM_001002836.3_3 - 0.072 12.8 3.3 35 4.2 0.1 3.6 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) XPA_N PF01286.16 NM_001002836.3_3 - 0.081 12.8 29.0 8.7 6.3 0.1 7.7 9 0 0 9 9 8 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001002836.3_3 - 0.16 12.6 21.2 1.7 9.3 1.7 4.9 3 2 3 6 6 5 0 zinc-ribbon family FYDLN_acid PF09538.8 NM_001002836.3_3 - 0.22 12.1 19.3 6.7 7.3 0.7 7.6 4 2 3 7 7 7 0 Protein of unknown function (FYDLN_acid) SprT-like PF10263.7 NM_001002836.3_3 - 0.31 10.7 20.6 77 3.0 11.7 4.2 2 2 0 2 2 2 0 SprT-like family zf-met PF12874.5 NM_001002836.3_3 - 0.51 10.7 23.4 3.8 7.9 1.0 5.4 5 0 0 5 5 5 0 Zinc-finger of C2H2 type DUF2256 PF10013.7 NM_001002836.3_3 - 1.2 9.2 27.2 3.3 7.8 0.0 7.7 9 0 0 9 9 7 0 Uncharacterized protein conserved in bacteria (DUF2256) HypA PF01155.17 NM_001002836.3_3 - 1.4 8.8 24.3 4.1 7.3 0.8 4.9 3 2 1 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-UBP PF02148.17 NM_001002836.3_3 - 1.9 8.7 23.5 24 5.2 9.3 5.7 3 1 1 4 4 4 0 Zn-finger in ubiquitin-hydrolases and other protein zf-trcl PF13451.4 NM_001002836.3_3 - 3.5 7.4 36.9 4.7 7.1 0.1 9.3 9 1 0 9 9 9 0 Probable zinc-ribbon domain SPRY PF00622.26 NM_001184992.1_1 - 1.1e-09 38.4 0.0 1.8e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_001184992.1_1 - 8.5e-05 22.0 0.5 0.0002 20.8 0.5 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_4 PF15227.4 NM_001184992.1_2 - 1.1e-10 41.4 3.6 2.4e-10 40.2 3.6 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 NM_001184992.1_2 - 2.5e-08 33.5 3.3 5.4e-08 32.4 3.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001184992.1_2 - 1e-07 31.7 5.9 3e-07 30.2 5.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_001184992.1_2 - 1.6e-07 31.0 2.5 3.2e-07 30.0 2.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001184992.1_2 - 6.7e-07 28.9 5.6 1.6e-06 27.7 5.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001184992.1_2 - 4.4e-06 26.7 7.9 4.4e-06 26.7 7.9 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 NM_001184992.1_2 - 7.4e-05 22.5 4.0 0.00016 21.4 4.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 NM_001184992.1_2 - 0.0004 20.0 5.7 0.00084 19.0 5.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 NM_001184992.1_2 - 0.015 15.3 1.1 0.027 14.5 1.1 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.4 NM_001184992.1_2 - 0.038 13.6 3.5 0.11 12.2 3.5 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.5 NM_001184992.1_2 - 0.045 13.7 1.2 0.099 12.6 1.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger C1_1 PF00130.20 NM_001184992.1_2 - 0.11 12.3 2.8 0.34 10.7 2.8 1.8 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-rbx1 PF12678.5 NM_001184992.1_2 - 9 6.5 12.3 0.53 10.5 6.8 1.8 2 0 0 2 2 1 0 RING-H2 zinc finger domain LIM PF00412.20 NM_001307951.1_3 - 2.4e-59 197.3 34.0 1.5e-15 57.0 2.4 4.2 4 0 0 4 4 4 4 LIM domain Ig_2 PF13895.4 NM_130786.3_3 - 2.8e-38 130.0 0.0 3.2e-15 56.1 0.0 5.2 5 0 0 5 5 5 5 Immunoglobulin domain Ig_3 PF13927.4 NM_130786.3_3 - 2.1e-17 63.4 0.0 0.0021 18.5 0.0 4.7 5 0 0 5 5 5 4 Immunoglobulin domain ig PF00047.23 NM_130786.3_3 - 2.9e-09 36.9 0.0 0.11 12.6 0.0 5.0 5 1 0 5 5 5 3 Immunoglobulin domain V-set PF07686.15 NM_130786.3_3 - 0.00037 20.5 0.0 4.4 7.4 0.0 4.7 4 1 1 5 5 5 1 Immunoglobulin V-set domain Izumo-Ig PF16706.3 NM_130786.3_3 - 0.0096 15.8 0.0 4 7.4 0.0 3.9 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain I-set PF07679.14 NM_130786.3_3 - 0.034 14.1 0.0 29 4.7 0.0 3.8 4 1 0 4 4 4 0 Immunoglobulin I-set domain IRK PF01007.18 NM_001276437.1_2 - 4.9e-136 452.9 1.7 7.7e-136 452.2 1.7 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_001276437.1_2 - 0.0077 16.1 3.4 0.017 14.9 3.4 1.6 1 0 0 1 1 1 1 Ion channel DUF2182 PF09948.7 NM_001276437.1_2 - 0.11 12.2 0.1 0.21 11.3 0.1 1.3 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) Sedlin_N PF04628.11 NM_001318527.1_1 - 6e-17 61.9 0.2 8.8e-17 61.3 0.2 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.10 NM_001318527.1_1 - 0.013 15.3 0.0 0.02 14.7 0.0 1.1 1 0 0 1 1 1 0 Sybindin-like family Sedlin_N PF04628.11 NM_001318527.1_3 - 4e-05 23.6 0.0 5.7e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region zf-H2C2_2 PF13465.4 NM_001286698.1_2 - 1.2e-97 316.2 68.9 1e-09 38.3 0.9 12.5 12 0 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001286698.1_2 - 2.9e-67 219.4 77.3 4.8e-07 29.8 0.9 12.0 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001286698.1_2 - 2.5e-38 127.3 80.8 0.0029 18.2 0.6 12.6 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001286698.1_2 - 2.7e-23 81.3 70.0 0.0044 16.8 0.3 11.6 11 0 0 11 11 11 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001286698.1_2 - 3.1e-09 36.7 70.8 0.044 13.8 2.8 9.0 4 3 8 12 12 12 9 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001286698.1_2 - 3.7e-08 33.3 60.2 0.57 10.4 0.1 11.4 11 0 0 11 11 11 7 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001286698.1_2 - 4.2e-08 33.7 51.2 0.043 14.4 2.2 6.4 1 1 5 6 6 6 5 zinc-ribbon family XPA_N PF01286.16 NM_001286698.1_2 - 7.8e-08 32.1 54.9 1.9 8.5 0.4 11.5 11 0 0 11 11 11 5 XPA protein N-terminal zf-C2H2_11 PF16622.3 NM_001286698.1_2 - 1.8e-07 30.7 57.9 0.21 11.3 0.1 11.3 11 0 0 11 11 11 5 zinc-finger C2H2-type C1_4 PF07975.10 NM_001286698.1_2 - 0.00075 19.6 56.0 0.011 15.9 1.2 7.2 4 2 2 7 7 7 4 TFIIH C1-like domain YhfH PF14149.4 NM_001286698.1_2 - 0.029 14.2 46.0 13 5.8 0.2 10.8 11 0 0 11 11 10 0 YhfH-like protein zf-trcl PF13451.4 NM_001286698.1_2 - 0.86 9.4 52.7 3.2 7.6 5.6 9.9 8 3 0 8 8 8 0 Probable zinc-ribbon domain TFIIS_C PF01096.16 NM_001286698.1_2 - 3.5 7.4 49.8 24 4.7 0.1 11.3 11 0 0 11 11 11 0 Transcription factor S-II (TFIIS) Sema PF01403.17 NM_030913.4_1 - 2.2e-116 389.0 0.0 3.2e-116 388.5 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 NM_030913.4_1 - 0.00023 21.5 7.7 0.00059 20.2 7.7 1.7 1 0 0 1 1 1 1 Plexin repeat MFS_1 PF07690.14 NM_152778.2_2 - 1e-35 123.2 33.8 1.1e-29 103.4 17.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_152778.2_2 - 3.6e-10 39.2 6.2 3.6e-10 39.2 6.2 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter RNase_PH PF01138.19 NM_033109.4_1 - 7.2e-40 136.4 0.0 5e-20 72.2 0.0 2.3 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 NM_033109.4_1 - 1.5e-16 60.0 0.6 1.2e-11 44.3 0.0 2.5 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 PNPase PF03726.12 NM_033109.4_1 - 2e-08 34.5 0.5 5.6e-08 33.0 0.5 1.8 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain KH_1 PF00013.27 NM_033109.4_1 - 1.3e-07 31.2 0.0 1.1e-06 28.2 0.0 2.3 2 0 0 2 2 2 1 KH domain S1 PF00575.21 NM_033109.4_1 - 0.0001 22.4 0.0 0.00037 20.6 0.0 2.0 2 0 0 2 2 2 1 S1 RNA binding domain DUF4209 PF13910.4 NM_001278532.1_3 - 2.9e-30 104.2 0.7 3.2e-24 84.8 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4209) Defensin_3 PF08131.9 NM_032012.3_2 - 0.064 13.3 0.6 0.17 11.9 0.6 1.7 1 0 0 1 1 1 0 Defensin-like peptide family AI-2E_transport PF01594.14 NM_032012.3_3 - 1.4e-10 40.7 26.7 1.9e-10 40.3 16.4 4.2 4 0 0 4 4 4 3 AI-2E family transporter Ras PF00071.20 NM_030907.3_3 - 6.1e-10 38.8 0.0 8.3e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_030907.3_3 - 1.1e-06 28.8 0.0 1.5e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase CbiA PF01656.21 NM_030907.3_3 - 0.012 15.5 0.8 0.022 14.7 0.8 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.4 NM_030907.3_3 - 0.045 14.0 0.1 0.09 13.0 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.10 NM_030907.3_3 - 0.054 13.3 0.1 0.094 12.5 0.1 1.4 1 0 0 1 1 1 0 NACHT domain DUF258 PF03193.14 NM_030907.3_3 - 0.12 12.2 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_32 PF13654.4 NM_030907.3_3 - 0.15 10.6 0.0 0.22 10.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 NM_030907.3_3 - 0.23 11.0 0.1 0.33 10.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.13 NM_030907.3_3 - 0.26 11.1 0.7 0.38 10.5 0.7 1.2 1 0 0 1 1 1 0 NTPase Dpy-30 PF05186.11 NM_152327.3_3 - 3.6e-20 71.2 0.2 9e-20 70.0 0.2 1.7 1 0 0 1 1 1 1 Dpy-30 motif ADK PF00406.20 NM_152327.3_3 - 1.2e-10 41.5 0.1 1.7e-06 28.1 0.1 2.9 2 1 0 2 2 2 2 Adenylate kinase AAA_18 PF13238.4 NM_152327.3_3 - 2e-05 25.0 2.5 2.3e-05 24.8 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.4 NM_152327.3_3 - 7.4e-05 23.1 11.7 0.00036 20.9 0.7 3.9 3 1 0 3 3 3 1 AAA domain AAA PF00004.27 NM_152327.3_3 - 0.0032 17.8 0.0 0.021 15.1 0.0 2.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Hydin_ADK PF17213.1 NM_152327.3_3 - 0.0045 17.2 0.0 0.0045 17.2 0.0 2.4 3 0 0 3 3 3 1 Hydin Adenylate kinase-like domain Epimerase PF01370.19 NM_152327.3_3 - 0.012 14.9 0.1 0.028 13.7 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family AAA_16 PF13191.4 NM_152327.3_3 - 0.019 15.2 0.1 0.1 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.4 NM_152327.3_3 - 0.063 13.4 0.0 0.063 13.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.4 NM_152327.3_3 - 0.072 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.21 NM_152327.3_3 - 0.13 12.2 0.1 0.95 9.4 0.0 2.5 3 0 0 3 3 3 0 50S ribosome-binding GTPase NDUF_B4 PF07225.10 NM_152327.3_3 - 0.17 11.7 1.1 0.36 10.6 1.1 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) zf-C2H2 PF00096.24 NM_001024683.1_1 - 8.5e-11 41.6 6.5 7.6e-06 26.0 2.2 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001024683.1_1 - 8.2e-09 35.4 5.9 9.8e-07 28.8 0.6 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001024683.1_1 - 3.9e-06 27.1 6.8 0.03 15.0 1.6 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001024683.1_1 - 0.0008 19.3 1.4 0.002 18.1 1.4 1.7 1 0 0 1 1 1 1 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001024683.1_1 - 0.061 13.2 3.7 2.2 8.2 0.7 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Nudix_N_2 PF14803.4 NM_001024683.1_1 - 0.062 13.1 1.8 2.1 8.2 0.4 2.6 2 0 0 2 2 2 0 Nudix N-terminal zf-C2H2_11 PF16622.3 NM_001024683.1_1 - 0.64 9.7 4.2 1 9.0 1.3 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type DEAD PF00270.27 NM_001320596.1_2 - 2.2e-46 157.7 0.0 4e-46 156.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase P68HR PF08061.9 NM_001320596.1_2 - 1.5e-33 114.5 22.6 1.5e-17 63.3 2.4 3.0 3 0 0 3 3 3 2 P68HR (NUC004) repeat Helicase_C PF00271.29 NM_001320596.1_2 - 1.2e-30 106.0 0.0 2.4e-30 105.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_001320596.1_2 - 0.002 18.0 0.0 0.0091 15.9 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 NM_001320596.1_2 - 0.013 14.6 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-H2C2_2 PF13465.4 NM_001290318.1_2 - 4.1e-92 298.7 115.5 3.7e-08 33.3 1.5 18.1 18 0 0 18 18 18 15 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001290318.1_2 - 5.7e-70 227.9 132.1 4.9e-06 26.6 0.6 18.0 17 0 0 17 17 17 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001290318.1_2 - 7.4e-29 97.8 131.9 0.0043 17.6 0.4 18.2 18 0 0 18 18 18 13 C2H2-type zinc finger KRAB PF01352.25 NM_001290318.1_2 - 9.2e-20 69.9 2.8 1.8e-19 69.0 2.8 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001290318.1_2 - 1.2e-10 41.1 61.3 0.048 13.7 1.3 9.0 4 1 4 9 9 9 8 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001290318.1_2 - 3.2e-09 36.7 60.0 0.81 9.9 0.2 13.8 13 0 0 13 13 13 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001290318.1_2 - 4.4e-07 29.5 92.7 0.19 11.6 0.3 15.2 15 0 0 15 15 15 9 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 NM_001290318.1_2 - 3.4e-05 24.4 49.9 0.57 10.8 1.8 8.3 1 1 7 8 8 8 4 zinc-ribbon family DUF3268 PF11672.6 NM_001290318.1_2 - 7.6 6.8 45.5 4.6 7.5 0.4 7.1 5 1 2 8 8 8 0 zinc-finger-containing domain Integrin_beta PF00362.16 NM_001282390.1_1 - 1.1e-109 365.8 0.0 1.5e-109 365.3 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 NM_001282390.1_1 - 7.7e-20 70.2 0.1 1.4e-19 69.3 0.1 1.5 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 NM_001282390.1_1 - 1.1e-16 60.9 6.3 1.1e-16 60.9 6.3 3.0 3 1 0 3 3 3 1 Integrin beta tail domain EGF_2 PF07974.11 NM_001282390.1_1 - 1.8e-10 40.9 86.6 0.00013 22.1 17.1 6.1 4 1 1 5 5 5 4 EGF-like domain DENN PF02141.19 NM_144973.3_1 - 3.6e-61 206.2 3.3 6.7e-61 205.4 3.3 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain RUN PF02759.17 NM_144973.3_1 - 9.1e-41 138.9 1.9 5.8e-20 71.5 1.9 2.6 2 0 0 2 2 2 2 RUN domain dDENN PF03455.17 NM_144973.3_1 - 2.5e-18 65.7 1.7 2.5e-18 65.7 1.7 2.7 3 0 0 3 3 3 1 dDENN domain uDENN PF03456.16 NM_144973.3_1 - 1.8e-14 54.2 0.1 5.3e-14 52.7 0.1 1.9 1 0 0 1 1 1 1 uDENN domain PLAT PF01477.21 NM_144973.3_1 - 6.9e-10 39.4 0.0 1.3e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain zf-C2H2 PF00096.24 NM_001003700.1_1 - 5e-32 108.4 120.6 0.00011 22.4 2.6 14.9 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001003700.1_1 - 9e-27 91.3 115.3 0.00054 20.4 1.0 15.3 14 0 0 14 14 14 13 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_001003700.1_1 - 1.3e-24 85.3 94.9 8.1e-07 29.1 0.1 16.7 16 1 0 16 16 16 7 Zinc-finger double domain zf-H2C2_5 PF13909.4 NM_001003700.1_1 - 3.5e-07 29.7 0.0 3.5e-07 29.7 0.0 10.6 11 0 0 11 11 11 4 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 NM_001003700.1_1 - 0.014 15.2 0.3 0.014 15.2 0.3 13.9 15 0 0 15 15 15 0 C2H2-type zinc finger ASD2 PF08687.9 NM_001003700.1_1 - 0.48 9.8 1.9 1.3 8.5 1.9 1.6 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 FYDLN_acid PF09538.8 NM_001003700.1_1 - 0.6 10.7 16.5 0.53 10.9 2.1 4.9 4 1 0 4 4 4 0 Protein of unknown function (FYDLN_acid) DUF629 PF04780.10 NM_001003700.1_1 - 2.1 6.7 18.1 0.22 9.9 1.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF629) ApoL PF05461.9 NM_145343.2_2 - 1.8e-120 401.9 0.1 2.2e-120 401.6 0.1 1.1 1 0 0 1 1 1 1 Apolipoprotein L Metal_resist PF13801.4 NM_145343.2_2 - 0.071 13.2 0.4 0.19 11.8 0.4 1.7 1 0 0 1 1 1 0 Heavy-metal resistance EMI PF07546.11 NM_052846.1_3 - 9.3e-16 58.2 7.1 9.3e-16 58.2 7.1 2.7 2 0 0 2 2 2 1 EMI domain DUF1664 PF07889.10 NM_052846.1_3 - 0.0017 18.2 8.5 0.17 11.8 0.7 5.5 4 1 1 6 6 6 2 Protein of unknown function (DUF1664) Golgin_A5 PF09787.7 NM_052846.1_3 - 0.0046 16.3 1.5 0.0046 16.3 1.5 2.7 3 1 0 3 3 3 1 Golgin subfamily A member 5 BicD PF09730.7 NM_052846.1_3 - 0.0061 14.9 1.0 0.011 14.1 1.0 1.3 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D Baculo_PEP_C PF04513.10 NM_052846.1_3 - 0.013 15.4 9.9 1 9.3 1.6 5.3 4 1 2 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.10 NM_052846.1_3 - 0.018 14.3 14.0 3.2 6.9 0.2 4.6 4 1 2 6 6 5 0 Reovirus sigma C capsid protein CorA PF01544.16 NM_052846.1_3 - 0.044 12.9 1.8 0.24 10.5 0.2 2.5 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Spc7 PF08317.9 NM_052846.1_3 - 0.052 12.3 12.8 0.069 11.9 1.9 4.0 3 1 1 4 4 4 0 Spc7 kinetochore protein HMMR_N PF15905.3 NM_052846.1_3 - 0.054 12.8 1.1 2.9 7.2 0.0 2.9 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DUF2730 PF10805.6 NM_052846.1_3 - 0.067 13.2 2.0 0.48 10.4 0.2 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF2730) AAA_13 PF13166.4 NM_052846.1_3 - 0.091 11.3 0.1 0.2 10.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain COG2 PF06148.9 NM_052846.1_3 - 0.096 12.6 10.5 0.43 10.5 2.2 4.6 4 1 1 5 5 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Yuri_gagarin PF15934.3 NM_052846.1_3 - 0.14 11.8 3.9 0.05 13.3 0.3 2.0 2 0 0 2 2 1 0 Yuri gagarin ATG16 PF08614.9 NM_052846.1_3 - 0.19 11.7 23.8 0.1 12.6 0.5 3.8 3 2 1 4 4 3 0 Autophagy protein 16 (ATG16) CALCOCO1 PF07888.9 NM_052846.1_3 - 0.22 9.9 11.4 0.032 12.7 5.3 2.2 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TACC PF05010.12 NM_052846.1_3 - 0.22 11.1 1.9 2.8 7.5 0.5 2.9 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC) CHDCT2 PF08074.9 NM_052846.1_3 - 0.24 11.5 3.5 0.3 11.1 0.5 2.6 2 1 0 3 3 2 0 CHDCT2 (NUC038) domain EzrA PF06160.10 NM_052846.1_3 - 0.27 9.3 0.1 0.64 8.0 0.1 1.6 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA SlyX PF04102.10 NM_052846.1_3 - 0.35 11.4 26.5 0.25 11.8 0.7 7.5 7 2 2 9 9 7 0 SlyX DUF4795 PF16043.3 NM_052846.1_3 - 0.35 10.3 2.5 12 5.2 1.3 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4795) Filament PF00038.19 NM_052846.1_3 - 0.44 10.0 9.2 0.42 10.0 1.1 3.5 2 1 2 4 4 4 0 Intermediate filament protein Rootletin PF15035.4 NM_052846.1_3 - 0.45 10.4 14.5 0.015 15.3 4.3 3.3 2 1 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion HMMR_C PF15908.3 NM_052846.1_3 - 0.55 10.4 1.9 13 5.9 0.2 2.9 3 0 0 3 3 2 0 Hyaluronan mediated motility receptor C-terminal DUF3450 PF11932.6 NM_052846.1_3 - 0.6 9.2 12.6 0.65 9.1 1.9 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3450) DUF16 PF01519.14 NM_052846.1_3 - 0.63 10.4 6.1 0.35 11.2 1.0 3.1 2 1 2 4 4 2 0 Protein of unknown function DUF16 Uso1_p115_C PF04871.11 NM_052846.1_3 - 0.76 10.0 12.3 0.54 10.5 1.3 4.0 3 1 1 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region IFT57 PF10498.7 NM_052846.1_3 - 0.8 8.5 3.0 0.88 8.4 0.9 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 APG6 PF04111.10 NM_052846.1_3 - 0.95 8.7 5.3 2.8 7.1 2.6 2.7 2 1 1 3 3 3 0 Autophagy protein Apg6 Lebercilin PF15619.4 NM_052846.1_3 - 1.1 8.7 15.4 0.18 11.3 2.3 3.6 3 1 1 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease Fez1 PF06818.13 NM_052846.1_3 - 1.4 9.2 10.2 1.2 9.4 3.0 3.3 1 1 1 2 2 2 0 Fez1 BLOC1_2 PF10046.7 NM_052846.1_3 - 1.7 8.9 3.1 9.7 6.4 0.0 3.7 3 1 1 4 4 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TBPIP PF07106.11 NM_052846.1_3 - 1.9 8.1 3.8 8 6.1 0.1 3.1 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMF_TATA_bd PF12325.6 NM_052846.1_3 - 2.9 8.0 8.1 0.76 9.9 0.8 3.6 3 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF3584 PF12128.6 NM_052846.1_3 - 4.3 4.6 10.0 2.8 5.2 5.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3584) Tropomyosin PF00261.18 NM_052846.1_3 - 4.7 6.4 6.7 1.9 7.7 0.7 3.2 2 1 1 4 4 4 0 Tropomyosin OmpH PF03938.12 NM_052846.1_3 - 5 7.0 6.6 1.6 8.6 1.6 2.5 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Syntaxin-6_N PF09177.9 NM_052846.1_3 - 5.5 7.5 4.9 4.7 7.7 0.5 3.2 2 1 1 3 3 2 0 Syntaxin 6, N-terminal NPV_P10 PF05531.10 NM_052846.1_3 - 5.9 7.3 11.7 6.4 7.2 0.1 5.3 4 2 3 7 7 6 0 Nucleopolyhedrovirus P10 protein ABC_tran_CTD PF16326.3 NM_052846.1_3 - 7 6.8 13.3 12 6.1 0.2 5.2 6 0 0 6 6 5 0 ABC transporter C-terminal domain HIP1_clath_bdg PF16515.3 NM_052846.1_3 - 7.7 7.1 15.4 2 8.9 2.9 4.2 3 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Laminin_II PF06009.10 NM_052846.1_3 - 8 6.3 8.6 4.9 7.0 1.8 3.5 3 1 1 4 4 2 0 Laminin Domain II Orai-1 PF07856.10 NM_032831.3_2 - 3.9e-70 235.0 1.0 5.6e-70 234.5 1.0 1.2 1 0 0 1 1 1 1 Mediator of CRAC channel activity EF-hand_5 PF13202.4 NM_001267559.1_2 - 6.9e-05 22.1 0.0 0.00019 20.7 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.30 NM_001267559.1_2 - 0.0001 21.5 0.0 0.00026 20.2 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.4 NM_001267559.1_2 - 0.00017 21.1 0.0 0.0005 19.7 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain DUF4719 PF15843.3 NM_001267559.1_2 - 0.042 13.8 0.3 0.083 12.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) EF-hand_7 PF13499.4 NM_001267559.1_2 - 0.12 12.7 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_7 PF13499.4 NM_001267559.1_3 - 0.029 14.7 0.1 0.044 14.1 0.1 1.2 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.4 NM_001267559.1_3 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.30 NM_001267559.1_3 - 0.16 11.5 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 EF hand Abhydrolase_3 PF07859.11 NM_001146277.1_3 - 7.8e-42 143.4 0.1 5.2e-27 94.9 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_001146277.1_3 - 0.0041 16.5 0.0 0.011 15.1 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family NMU PF02070.13 NM_001292046.1_2 - 1.9e-13 49.9 2.8 4.1e-13 48.8 2.8 1.6 1 0 0 1 1 1 1 Neuromedin U Snf7 PF03357.19 NM_002768.4_3 - 1.3e-10 41.0 15.2 2e-10 40.4 15.2 1.2 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.12 NM_002768.4_3 - 0.79 9.5 8.4 1.4 8.7 8.4 1.3 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway MRP-L46 PF11788.6 NM_022163.3_2 - 1e-17 64.8 0.9 1.6e-17 64.2 0.9 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.26 NM_022163.3_2 - 0.0066 16.4 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain RBP_receptor PF14752.4 NM_001142617.1_1 - 3.2e-258 858.2 5.5 3.7e-258 858.0 5.5 1.0 1 0 0 1 1 1 1 Retinol binding protein receptor SUR7 PF06687.10 NM_001142617.1_1 - 1.2 8.6 5.7 3.4 7.1 5.7 1.7 1 0 0 1 1 1 0 SUR7/PalI family SAM_2 PF07647.15 NM_174920.3_1 - 3.9e-12 46.0 0.2 6.2e-12 45.3 0.2 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_174920.3_1 - 2.1e-11 43.9 0.2 3.6e-11 43.2 0.2 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_174920.3_1 - 0.065 13.1 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Pkinase PF00069.23 NM_003688.3_2 - 1.4e-67 227.7 0.0 2.1e-67 227.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Guanylate_kin PF00625.19 NM_003688.3_2 - 8.3e-61 204.7 0.1 1.4e-60 203.9 0.1 1.3 1 0 0 1 1 1 1 Guanylate kinase Pkinase_Tyr PF07714.15 NM_003688.3_2 - 2.2e-29 102.4 0.0 3.3e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase L27 PF02828.14 NM_003688.3_2 - 1.4e-24 85.4 12.4 3e-15 55.6 0.4 3.6 4 0 0 4 4 4 2 L27 domain PDZ PF00595.22 NM_003688.3_2 - 2.9e-16 59.4 0.5 6e-16 58.4 0.5 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_2 PF07653.15 NM_003688.3_2 - 4.3e-12 45.4 0.0 8.3e-12 44.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_003688.3_2 - 1.4e-07 30.9 0.1 2.9e-07 29.9 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_003688.3_2 - 0.0002 21.0 0.0 0.00042 20.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Kinase-like PF14531.4 NM_003688.3_2 - 0.0043 16.3 0.0 0.043 13.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like PDZ_2 PF13180.4 NM_003688.3_2 - 0.013 15.7 0.0 0.026 14.7 0.0 1.4 1 0 0 1 1 1 0 PDZ domain CKAP2_C PF15297.4 NM_152515.4_2 - 3.2e-52 177.6 22.3 9.6e-36 123.4 12.6 3.1 3 0 0 3 3 3 2 Cytoskeleton-associated protein 2 C-terminus DUF1725 PF08333.9 NM_152515.4_2 - 0.00022 20.6 2.7 0.00047 19.6 2.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) MBOAT PF03062.17 NM_020707.3_2 - 1.8e-11 43.9 10.9 3.4e-11 42.9 9.3 1.9 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family CDP-OH_P_tran_2 PF08009.9 NM_020707.3_2 - 1.1 9.0 9.6 0.13 12.0 2.2 3.4 3 1 1 4 4 4 0 CDP-alcohol phosphatidyltransferase 2 Homeobox PF00046.27 NM_153427.2_3 - 3.9e-22 77.7 9.2 6.9e-22 76.9 9.2 1.4 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 NM_153427.2_3 - 7.2e-08 31.9 1.1 7.2e-08 31.9 1.1 1.9 2 0 0 2 2 2 1 OAR domain Homeobox_KN PF05920.9 NM_153427.2_3 - 0.0061 16.3 0.6 0.018 14.8 0.6 1.8 1 0 0 1 1 1 1 Homeobox KN domain PARP PF00644.18 NM_020367.5_1 - 4.2e-49 166.9 0.1 5.9e-49 166.4 0.1 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.18 NM_020367.5_1 - 3.5e-15 56.2 0.1 6.9e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 WWE domain Proteasome_A_N PF10584.7 NM_001282233.1_2 - 1.3e-08 34.2 0.1 2.1e-08 33.5 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Proteasome PF00227.24 NM_001282233.1_3 - 2.6e-44 150.8 0.1 3.4e-44 150.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF4642 PF15484.4 NM_001143959.1_1 - 9.7e-78 259.6 5.4 1.2e-77 259.3 5.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4642) CD34_antigen PF06365.10 NM_001143959.1_1 - 0.0036 16.8 0.0 0.0064 16.0 0.0 1.4 1 1 0 1 1 1 1 CD34/Podocalyxin family ECSCR PF15820.3 NM_001143959.1_1 - 0.012 15.3 0.1 0.023 14.4 0.1 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Tmemb_9 PF05434.9 NM_001143959.1_1 - 0.74 9.5 5.0 1.1 9.0 0.3 2.2 2 0 0 2 2 2 0 TMEM9 RRM_1 PF00076.20 NM_173848.5_3 - 1e-10 41.1 0.0 1.7e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XhlA PF10779.7 NM_173848.5_3 - 0.1 12.7 6.0 0.18 11.9 6.0 1.4 1 0 0 1 1 1 0 Haemolysin XhlA ORF11CD3 PF10549.7 NM_173848.5_3 - 2.3 8.3 4.6 5.2 7.1 1.8 2.2 2 0 0 2 2 2 0 ORF11CD3 domain V-set PF07686.15 NM_001282585.1_2 - 1.9e-33 114.8 0.0 1.4e-19 70.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 NM_001282585.1_2 - 3.6e-08 33.3 0.0 0.0034 17.4 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001282585.1_2 - 7.4e-07 29.6 0.0 0.0066 16.9 0.0 3.0 2 2 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_001282585.1_2 - 1.3e-05 25.0 0.0 0.24 11.3 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001282585.1_2 - 3.6e-05 23.9 0.0 0.041 14.1 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.3 NM_001282585.1_2 - 0.014 15.3 0.0 8.5 6.4 0.0 3.0 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 NM_001282585.1_2 - 0.056 13.5 0.0 1.6 8.8 0.0 2.3 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 DUF347 PF03988.10 NM_001282585.1_2 - 0.11 12.6 1.3 0.21 11.6 1.3 1.5 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) Ldl_recept_a PF00057.16 NM_001304263.1_2 - 3.3e-20 71.9 23.9 5.3e-10 39.2 6.2 2.6 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.5 NM_001304263.1_2 - 5.3 6.7 11.7 8.8 6.0 11.7 1.2 1 0 0 1 1 1 0 Glucosidase II beta subunit-like DUF4071 PF13281.4 NM_001297609.1_3 - 3.7e-147 490.1 0.0 1.3e-146 488.3 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4071) Pkinase PF00069.23 NM_001297609.1_3 - 1.4e-61 208.0 0.0 2.1e-61 207.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001297609.1_3 - 1.2e-38 132.8 0.0 1.8e-38 132.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KSR1-SAM PF13543.4 NM_001297609.1_3 - 0.041 13.9 0.0 0.094 12.7 0.0 1.5 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 DAO PF01266.22 NM_001134707.1_3 - 3.4e-63 214.2 1.9 5.4e-63 213.5 1.9 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T PF01571.19 NM_001134707.1_3 - 5.4e-63 212.6 0.0 8.3e-63 212.0 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain FAO_M PF16350.3 NM_001134707.1_3 - 8.1e-20 70.8 2.8 4.1e-19 68.5 3.4 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase central domain GCV_T_C PF08669.9 NM_001134707.1_3 - 4.4e-12 45.9 0.0 1.2e-11 44.5 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.10 NM_001134707.1_3 - 0.0085 16.1 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Sarcosine oxidase, gamma subunit family Pyr_redox_2 PF07992.12 NM_001134707.1_3 - 0.0094 15.1 0.1 0.041 13.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase PrpF PF04303.11 NM_001134707.1_3 - 0.16 10.8 0.1 0.25 10.1 0.1 1.2 1 0 0 1 1 1 0 PrpF protein LIM PF00412.20 NM_001080436.1_1 - 5.6e-32 109.6 31.6 3.2e-12 46.3 5.2 3.3 3 0 0 3 3 3 3 LIM domain Ski_Sno PF02437.15 NM_053281.3_3 - 1.2e-36 124.7 0.1 2.8e-36 123.4 0.1 1.6 1 0 0 1 1 1 1 SKI/SNO/DAC family Corona_7 PF02398.14 NM_001322136.1_1 - 1.7 9.1 11.8 60 4.2 0.0 6.1 7 1 0 7 7 7 0 Coronavirus protein 7 zf-H2C2_2 PF13465.4 NM_001322136.1_3 - 9.3e-147 471.4 147.8 4e-08 33.2 1.0 21.9 21 0 0 21 21 21 21 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001322136.1_3 - 3.2e-116 373.6 157.2 7.6e-07 29.1 1.0 20.6 20 0 0 20 20 20 20 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001322136.1_3 - 2.6e-54 177.0 145.7 0.0026 18.3 0.4 20.8 20 0 0 20 20 20 20 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001322136.1_3 - 2.9e-32 109.9 136.3 0.0092 15.8 0.7 22.3 20 3 0 20 20 20 17 C2H2-type zinc finger KRAB PF01352.25 NM_001322136.1_3 - 1.4e-25 88.5 0.1 2.6e-25 87.7 0.1 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001322136.1_3 - 6.3e-25 86.9 102.2 0.028 14.4 2.8 16.6 5 4 14 19 19 19 17 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001322136.1_3 - 1.9e-21 75.4 84.1 0.41 10.3 0.1 20.1 20 0 0 20 20 20 9 zinc-finger C2H2-type XPA_N PF01286.16 NM_001322136.1_3 - 2.7e-17 62.3 61.2 9 6.3 0.0 20.1 20 0 0 20 20 20 0 XPA protein N-terminal C1_1 PF00130.20 NM_001322136.1_3 - 6.4e-13 48.2 72.3 0.18 11.6 0.5 14.1 1 1 17 18 18 18 13 Phorbol esters/diacylglycerol binding domain (C1 domain) SprT-like PF10263.7 NM_001322136.1_3 - 6e-11 42.3 95.4 0.042 13.5 3.0 9.9 2 2 8 10 10 10 8 SprT-like family zinc_ribbon_15 PF17032.3 NM_001322136.1_3 - 3.9e-09 37.0 83.3 0.37 11.4 0.7 10.8 1 1 12 13 13 13 10 zinc-ribbon family C1_4 PF07975.10 NM_001322136.1_3 - 4.1e-06 26.8 84.5 0.56 10.4 1.8 12.8 3 2 11 15 15 15 5 TFIIH C1-like domain HypA PF01155.17 NM_001322136.1_3 - 1.6e-05 24.7 71.5 2 8.3 0.7 10.9 1 1 13 14 14 14 8 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FAM178 PF14816.4 NM_001322136.1_3 - 8.5e-05 21.6 14.0 16 4.2 0.1 9.3 1 1 7 11 11 11 0 Family of unknown function, FAM178 zf-C2H2_jaz PF12171.6 NM_001322136.1_3 - 0.0073 16.5 86.5 4.1 7.7 0.4 19.3 20 0 0 20 20 20 3 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_001322136.1_3 - 0.016 15.4 71.6 0.35 11.1 1.5 10.1 3 2 5 12 12 12 0 zinc-finger-containing domain tRNA-synt_2d PF01409.18 NM_001322136.1_3 - 1 8.6 11.0 9.8 5.4 0.1 5.3 5 2 1 7 7 7 0 tRNA synthetases class II core domain (F) ZZ PF00569.15 NM_001322136.1_3 - 2.3 8.0 93.4 12 5.7 0.3 19.4 20 0 0 20 20 20 0 Zinc finger, ZZ type FYDLN_acid PF09538.8 NM_001322136.1_3 - 3.1 8.4 44.8 29 5.3 0.2 14.1 1 1 14 15 15 15 0 Protein of unknown function (FYDLN_acid) TPR_17 PF13431.4 NM_032847.2_2 - 0.0025 18.0 4.5 0.013 15.7 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_032847.2_2 - 0.0036 16.8 0.5 1.2 8.8 0.0 2.5 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.4 NM_032847.2_2 - 0.062 13.5 4.1 0.37 11.0 0.4 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_032847.2_2 - 0.063 13.8 3.8 34 5.2 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4372 PF14294.4 NM_032847.2_2 - 0.071 13.1 0.2 0.21 11.6 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4372) TPR_16 PF13432.4 NM_032847.2_2 - 0.14 12.8 3.5 0.64 10.6 1.3 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_032847.2_2 - 0.36 10.9 4.4 2.7 8.1 2.1 2.9 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.26 NM_032847.2_2 - 0.76 9.6 6.0 30 4.5 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_032847.2_2 - 3.8 7.7 5.8 9.6 6.5 0.5 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat IRK PF01007.18 NM_002243.4_2 - 5.1e-136 452.8 1.7 7.9e-136 452.2 1.7 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_002243.4_2 - 0.0079 16.0 3.4 0.017 14.9 3.4 1.6 1 0 0 1 1 1 1 Ion channel DUF2182 PF09948.7 NM_002243.4_2 - 0.12 12.2 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) DNMT1-RFD PF12047.6 NM_001318730.1_3 - 8e-48 162.0 0.0 1.4e-46 157.9 0.0 2.7 2 0 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain DNA_methylase PF00145.15 NM_001318730.1_3 - 4.5e-47 160.9 0.0 4.5e-47 160.9 0.0 3.3 2 2 1 3 3 3 1 C-5 cytosine-specific DNA methylase BAH PF01426.16 NM_001318730.1_3 - 5.7e-46 155.2 0.0 1e-21 76.9 0.0 2.6 2 0 0 2 2 2 2 BAH domain DMAP_binding PF06464.9 NM_001318730.1_3 - 9e-21 74.6 2.9 9e-21 74.6 2.9 3.6 2 1 2 4 4 4 1 DMAP1-binding Domain zf-CXXC PF02008.18 NM_001318730.1_3 - 5.7e-15 54.9 21.5 1.8e-14 53.3 21.5 2.0 1 0 0 1 1 1 1 CXXC zinc finger domain HTH_12 PF08461.8 NM_001318730.1_3 - 0.1 12.5 0.1 0.25 11.2 0.1 1.6 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain Carbam_trans_N PF02543.13 NM_052950.3_1 - 0.23 10.9 1.5 0.35 10.4 1.5 1.1 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus WD40 PF00400.30 NM_052950.3_2 - 4.6e-18 65.1 10.7 1.3e-06 28.9 1.2 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat FYVE PF01363.19 NM_052950.3_2 - 4.3e-13 49.1 7.6 4.3e-13 49.1 7.6 2.0 2 0 0 2 2 2 1 FYVE zinc finger ANAPC4_WD40 PF12894.5 NM_052950.3_2 - 0.00084 19.5 0.0 0.6 10.3 0.0 3.0 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.9 NM_052950.3_2 - 0.062 11.9 0.0 2.5 6.6 0.0 2.5 2 0 0 2 2 2 0 Nup133 N terminal like FYVE_2 PF02318.14 NM_052950.3_2 - 1 9.5 7.9 0.4 10.8 4.2 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger LRR_4 PF12799.5 NM_024646.2_1 - 0.00018 21.6 8.7 0.02 15.2 0.2 3.7 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_024646.2_1 - 0.15 11.7 2.7 0.61 9.8 0.3 3.0 2 1 1 3 3 3 0 Leucine rich repeat DUF3361 PF11841.6 NM_024646.2_1 - 0.2 11.5 6.4 0.32 10.8 2.3 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3361) cNMP_binding PF00027.27 NM_001166111.1_1 - 3.4e-51 171.1 0.1 7.7e-17 61.0 0.0 3.5 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Patatin PF01734.20 NM_001166111.1_1 - 1.9e-23 83.6 0.1 4.1e-23 82.5 0.1 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase RabGAP-TBC PF00566.16 NM_001318809.1_2 - 5.7e-10 39.1 0.5 4.3e-08 33.0 0.2 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain TIR_2 PF13676.4 NM_148910.2_3 - 3.6e-10 39.9 0.0 5.4e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 TIR domain TIR PF01582.18 NM_148910.2_3 - 4.5e-05 23.2 0.0 6.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 TIR domain Spc7 PF08317.9 NM_182489.1_1 - 0.0049 15.7 1.7 0.0073 15.1 1.7 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein KASH_CCD PF14662.4 NM_182489.1_1 - 0.031 14.0 0.2 0.053 13.2 0.2 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH HLH PF00010.24 NM_182489.1_1 - 0.12 12.2 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain UMPH-1 PF05822.10 NM_001002009.2_1 - 2.8e-117 390.4 2.6 3.4e-117 390.2 2.6 1.1 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.5 NM_001002009.2_1 - 0.00086 19.6 0.1 0.0016 18.8 0.0 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase zf-ANAPC11 PF12861.5 NM_001002009.2_1 - 0.031 14.2 0.1 0.056 13.4 0.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger ACT_7 PF13840.4 NM_001002009.2_1 - 0.044 13.4 0.4 23 4.7 0.1 3.1 3 0 0 3 3 3 0 ACT domain DUF3180 PF11377.6 NM_001002009.2_3 - 0.022 14.8 1.6 0.042 13.9 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3180) UCR_UQCRX_QCR9 PF05365.10 NM_001003684.1_1 - 2.3e-15 56.1 0.1 3.8e-15 55.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like PARP PF00644.18 NM_022750.3_2 - 2.6e-41 141.4 0.8 4.7e-41 140.6 0.8 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.18 NM_022750.3_2 - 3.1e-18 65.9 0.9 5.7e-13 49.1 0.3 2.5 2 0 0 2 2 2 2 WWE domain zf-CCCH PF00642.22 NM_022750.3_2 - 0.00011 21.9 3.3 0.00011 21.9 3.3 4.7 4 0 0 4 4 4 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.3 NM_022750.3_2 - 0.014 16.0 13.0 0.26 11.9 1.8 3.6 3 0 0 3 3 3 0 Torus domain 7tm_4 PF13853.4 NM_001004467.1_1 - 8.9e-48 163.3 21.2 1.1e-47 162.9 21.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004467.1_1 - 6.7e-26 91.0 9.9 8.9e-26 90.6 9.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_001004467.1_2 - 0.0044 16.7 0.0 0.0057 16.3 0.0 1.1 1 0 0 1 1 1 1 Olfactory receptor OATP PF03137.18 NM_001009562.4_1 - 7.3e-161 536.0 16.8 9.2e-161 535.7 16.8 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 NM_001009562.4_1 - 3.8e-21 75.3 26.5 1.1e-15 57.3 10.3 3.2 3 1 0 3 3 3 3 Major Facilitator Superfamily Kazal_2 PF07648.13 NM_001009562.4_1 - 7.1e-13 48.4 4.4 1.5e-12 47.4 4.4 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Sugar_tr PF00083.22 NM_001009562.4_1 - 5.5e-07 28.7 19.8 7.5e-06 24.9 7.8 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter Kazal_1 PF00050.19 NM_001009562.4_1 - 0.00038 20.3 4.0 0.0011 18.7 4.0 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Lig_chan PF00060.24 NM_001009562.4_1 - 0.025 14.3 0.9 0.075 12.7 0.3 2.2 2 0 0 2 2 2 0 Ligand-gated ion channel 7tm_1 PF00001.19 NM_016083.4_1 - 1.8e-43 148.6 15.5 3.2e-43 147.8 15.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pkinase PF00069.23 NM_001166170.1_1 - 1.4e-65 221.2 0.0 1.8e-65 220.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001166170.1_1 - 2.7e-46 157.8 0.0 3.7e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001166170.1_1 - 6.4e-05 22.3 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001166170.1_1 - 0.011 14.9 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_2 PF13639.4 NM_014455.3_2 - 3.8e-13 49.3 8.2 3.8e-13 49.3 8.2 3.5 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.5 NM_014455.3_2 - 2.7e-08 33.8 4.4 1.2e-07 31.8 4.4 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 NM_014455.3_2 - 5.6e-08 32.4 7.5 5.6e-08 32.4 7.5 2.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 NM_014455.3_2 - 5.8e-08 32.2 3.9 5.8e-08 32.2 3.9 2.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.4 NM_014455.3_2 - 1.5e-06 28.0 5.8 1e-05 25.3 5.7 2.5 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 NM_014455.3_2 - 2.2e-06 27.4 5.4 2.2e-06 27.4 5.4 3.9 4 0 0 4 4 4 1 zinc-RING finger domain zinc_ribbon_9 PF14369.4 NM_014455.3_2 - 7.3e-06 26.0 3.6 7.3e-06 26.0 3.6 3.3 4 0 0 4 4 3 1 zinc-ribbon zf-C3HC4 PF00097.23 NM_014455.3_2 - 1.1e-05 25.1 6.8 1.1e-05 25.1 6.8 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_014455.3_2 - 5.1e-05 22.9 3.1 5.1e-05 22.9 3.1 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 NM_014455.3_2 - 0.00081 19.3 1.5 0.00081 19.3 1.5 2.1 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 NM_014455.3_2 - 0.0035 17.0 6.4 0.0035 17.0 6.4 4.0 4 1 1 5 5 4 1 Prokaryotic RING finger family 4 zf-Nse PF11789.6 NM_014455.3_2 - 0.061 13.0 4.0 0.12 12.1 4.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DZR PF12773.5 NM_014455.3_2 - 0.26 11.2 10.1 0.45 10.4 0.2 3.4 3 1 0 3 3 3 0 Double zinc ribbon HypA PF01155.17 NM_014455.3_2 - 0.42 10.5 10.9 0.89 9.5 0.1 2.6 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rad50_zn_hook PF04423.12 NM_014455.3_2 - 1.1 9.0 6.1 0.7 9.6 0.2 2.8 3 0 0 3 3 3 0 Rad50 zinc hook motif zinc-ribbons_6 PF07191.10 NM_014455.3_2 - 2.6 8.0 10.3 6.4 6.7 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbons zinc_ribbon_4 PF13717.4 NM_014455.3_2 - 4.6 7.1 5.9 2.9 7.8 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain DUF1272 PF06906.9 NM_014455.3_2 - 6 6.9 9.6 3.8 7.5 0.4 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1272) Arm_2 PF04826.11 NM_001161009.2_3 - 1.2e-112 375.4 10.5 1.5e-112 375.0 10.5 1.1 1 0 0 1 1 1 1 Armadillo-like V-ATPase_H_C PF11698.6 NM_001161009.2_3 - 0.01 15.8 0.7 0.034 14.2 0.2 2.0 2 0 0 2 2 2 0 V-ATPase subunit H Arm PF00514.21 NM_001161009.2_3 - 0.097 12.6 3.6 0.1 12.5 0.2 2.6 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.7 NM_001161009.2_3 - 0.13 12.2 2.5 0.1 12.5 0.7 1.8 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain Arm_3 PF16186.3 NM_001161009.2_3 - 0.3 10.5 1.5 8.6 5.9 0.1 2.3 2 0 0 2 2 2 0 Atypical Arm repeat UCH PF00443.27 NM_203494.4_1 - 1e-49 169.2 2.1 1.4e-49 168.8 2.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_203494.4_1 - 1.7e-11 44.2 3.1 2.7e-11 43.5 3.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Serpin PF00079.18 NM_001002235.2_1 - 1.5e-117 393.0 2.2 1.7e-117 392.7 2.2 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SF1-HH PF16275.3 NM_201998.2_3 - 6.9e-44 148.7 1.7 6.9e-44 148.7 1.7 1.9 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.27 NM_201998.2_3 - 1.7e-07 30.8 0.3 3.5e-07 29.8 0.3 1.6 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.21 NM_201998.2_3 - 0.00015 21.6 1.6 0.00033 20.5 1.6 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.4 NM_201998.2_3 - 0.04 13.5 1.3 0.17 11.5 0.8 2.4 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.4 NM_201998.2_3 - 0.32 10.9 2.4 0.22 11.4 0.2 1.8 2 0 0 2 2 2 0 Zinc knuckle OSCP PF00213.16 NM_001697.2_2 - 8.3e-46 156.1 0.8 1e-45 155.8 0.8 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit DUF3513 PF12026.6 NM_005864.3_3 - 4.8e-51 173.4 0.0 6.9e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3513) SH3_9 PF14604.4 NM_005864.3_3 - 3.3e-13 49.1 0.0 6.2e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_005864.3_3 - 2.2e-11 43.0 0.0 3.6e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_005864.3_3 - 2e-09 36.8 0.0 3.6e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain zf-LITAF-like PF10601.7 NM_005864.3_3 - 0.0047 17.0 1.2 0.011 15.8 1.2 1.5 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Peptidase_U57 PF05582.10 NM_005864.3_3 - 0.26 10.4 0.1 0.38 9.8 0.1 1.1 1 0 0 1 1 1 0 YabG peptidase U57 GAGE PF05831.9 NM_001303613.1_1 - 1.3e-43 147.8 1.1 1.5e-43 147.5 1.1 1.0 1 0 0 1 1 1 1 GAGE protein DNA_methylase PF00145.15 NM_001207056.1_1 - 5.6e-13 48.8 0.0 2.5e-11 43.4 0.0 2.1 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase PWWP PF00855.15 NM_001207056.1_1 - 1.1e-12 48.1 0.6 2e-12 47.2 0.6 1.4 1 0 0 1 1 1 1 PWWP domain PA_decarbox PF05870.9 NM_001207056.1_1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Phenolic acid decarboxylase (PAD) DUF2799 PF10973.6 NM_001083330.2_1 - 0.33 11.3 3.7 0.73 10.2 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2799) zf-C2H2 PF00096.24 NM_001083330.2_3 - 7.3e-80 259.1 104.3 3.8e-07 30.1 0.4 16.0 16 0 0 16 16 15 15 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001083330.2_3 - 1.6e-77 252.6 80.5 3.2e-06 27.2 0.4 16.2 15 1 1 16 16 16 14 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001083330.2_3 - 3.7e-47 154.7 101.4 0.0039 17.8 0.3 16.4 16 0 0 16 16 16 15 C2H2-type zinc finger KRAB PF01352.25 NM_001083330.2_3 - 9.6e-25 85.9 0.1 1.7e-24 85.1 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001083330.2_3 - 8.8e-14 51.3 33.5 4 7.7 0.0 13.8 14 0 0 14 14 14 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001083330.2_3 - 2.5e-09 36.7 88.8 0.023 14.5 1.6 15.0 14 1 0 14 14 14 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001083330.2_3 - 2.3e-08 33.9 61.9 0.028 14.4 0.7 10.7 3 2 11 14 14 14 8 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_001083330.2_3 - 6.2e-08 33.1 45.2 0.42 11.2 0.4 7.9 1 1 7 8 8 8 7 zinc-ribbon family ADK_lid PF05191.12 NM_001083330.2_3 - 2.8e-06 27.1 50.1 0.032 14.1 0.5 10.6 5 2 4 9 9 9 4 Adenylate kinase, active site lid zf-C2H2_11 PF16622.3 NM_001083330.2_3 - 1.1e-05 25.0 82.6 0.21 11.3 0.8 15.0 15 0 0 15 15 15 6 zinc-finger C2H2-type DUF3268 PF11672.6 NM_001083330.2_3 - 0.0023 18.1 43.3 0.38 11.0 1.2 8.2 4 2 3 9 9 9 4 zinc-finger-containing domain zf-trcl PF13451.4 NM_001083330.2_3 - 0.01 15.6 52.9 4.1 7.2 0.1 13.6 14 1 0 14 14 14 0 Probable zinc-ribbon domain Chordopox_RPO7 PF05864.10 NM_001083330.2_3 - 0.011 15.9 28.7 24 5.2 0.7 10.4 10 1 1 11 11 11 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) BHD_1 PF10403.7 NM_001083330.2_3 - 0.077 12.7 0.1 1.5 8.6 0.0 3.1 5 1 0 5 5 5 0 Rad4 beta-hairpin domain 1 zf-met PF12874.5 NM_001083330.2_3 - 0.76 10.1 70.6 3.6 8.0 0.1 13.9 14 0 0 14 14 14 0 Zinc-finger of C2H2 type CDC45 PF02724.12 NM_003504.4_3 - 6.7e-156 520.1 18.3 2e-152 508.6 18.3 2.9 1 1 0 1 1 1 1 CDC45-like protein DUF3848 PF12959.5 NM_003504.4_3 - 0.087 12.8 0.2 0.87 9.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) UBA2_C PF16195.3 NM_003504.4_3 - 1.5 9.4 4.5 49 4.6 4.4 2.3 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus KRAB PF01352.25 NM_001324261.1_2 - 4.3e-26 90.2 0.1 7.3e-26 89.5 0.1 1.4 1 0 0 1 1 1 1 KRAB box SQS_PSY PF00494.17 NM_001287743.1_1 - 3.7e-41 141.2 0.0 5e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase Octopine_DH PF02317.15 NM_001287743.1_1 - 0.11 12.5 0.3 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain Toxin_3 PF00537.16 NM_001010886.3_1 - 1.2 9.3 15.8 0.36 10.9 12.7 1.7 1 1 1 2 2 2 0 Scorpion toxin-like domain Forkhead PF00250.16 NM_003593.2_3 - 7.4e-32 109.4 0.2 1.3e-31 108.6 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain Keratin_B2_2 PF13885.4 NM_033187.1_1 - 5.5e-34 115.7 289.5 2.3e-10 40.1 58.6 6.5 1 1 5 6 6 6 6 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_033187.1_1 - 1.1e-11 44.8 216.8 9e-07 28.9 67.7 4.8 1 1 6 7 7 7 6 Keratin, high sulfur B2 protein ProSAAS PF07259.10 NM_013271.4_2 - 7.4e-103 342.2 25.4 7.4e-103 342.2 25.4 2.3 3 0 0 3 3 3 1 ProSAAS precursor UDPGT PF00201.16 NM_003360.4_2 - 7.3e-117 391.1 0.0 9.5e-117 390.7 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 NM_003360.4_2 - 8.3e-07 29.0 0.0 1.4e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Imm39 PF15568.4 NM_003360.4_2 - 0.15 12.0 0.1 0.3 11.1 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 39 DUF3128 PF11326.6 NM_173793.4_2 - 6.9e-11 42.2 5.3 1.7e-10 41.0 5.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) zf-A20 PF01754.14 NM_001242918.1_2 - 3e-12 46.1 8.8 7.8e-12 44.8 8.8 1.8 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.14 NM_001242918.1_2 - 6.3e-08 32.5 1.7 6.3e-08 32.5 1.7 2.7 2 0 0 2 2 2 1 AN1-like Zinc finger PsbX PF06596.9 NM_001318955.1_1 - 0.87 9.5 2.6 2.5 8.0 2.6 1.7 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) Endonuclease_NS PF01223.21 NM_001318955.1_3 - 4.9e-49 167.0 0.0 6.7e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease RE_HindIII PF09518.8 NM_001318955.1_3 - 0.052 12.6 0.0 7.3 5.6 0.0 2.1 2 0 0 2 2 2 0 HindIII restriction endonuclease JmjC PF02373.20 NM_001258249.1_1 - 7.9e-34 116.4 1.4 2.4e-33 114.9 1.4 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase TPR_1 PF00515.26 NM_001258249.1_1 - 1.4e-24 84.7 19.1 1.4e-05 24.5 0.0 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001258249.1_1 - 7.3e-14 50.6 18.9 0.14 12.3 0.1 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001258249.1_1 - 6.6e-13 47.6 17.0 0.0054 16.7 0.4 7.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001258249.1_1 - 8.7e-13 48.6 0.5 0.11 13.0 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001258249.1_1 - 3.4e-12 45.7 0.2 0.0085 16.3 0.0 4.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001258249.1_1 - 3.3e-08 33.6 9.9 0.32 11.2 0.2 4.9 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001258249.1_1 - 2.2e-06 27.8 2.5 2.3 9.2 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001258249.1_1 - 4.7e-06 26.9 9.5 0.063 13.7 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001258249.1_1 - 6.8e-06 25.6 9.9 0.63 10.1 0.2 6.1 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001258249.1_1 - 0.00028 20.8 2.6 0.012 15.6 0.1 3.6 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001258249.1_1 - 0.0052 16.3 11.6 0.15 11.7 0.0 5.6 3 2 3 6 6 6 1 TPR repeat SNAP PF14938.4 NM_001258249.1_1 - 0.077 12.3 13.2 0.033 13.5 1.1 3.0 2 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP TPR_15 PF13429.4 NM_001258249.1_1 - 0.41 9.7 7.4 0.46 9.5 3.2 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001258249.1_1 - 0.43 11.2 10.5 4.1 8.1 0.1 6.4 8 0 0 8 8 7 0 Tetratricopeptide repeat Nnf1 PF03980.12 NM_001258249.1_1 - 1.7 8.9 5.0 0.36 11.1 0.5 2.2 2 0 0 2 2 2 0 Nnf1 LRR_4 PF12799.5 NM_001079515.2_3 - 1.6e-18 66.3 14.3 0.00028 21.1 0.3 5.6 4 1 2 6 6 6 5 Leucine Rich repeats (2 copies) CAP_GLY PF01302.23 NM_001079515.2_3 - 2e-18 66.0 0.5 3.3e-18 65.3 0.5 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_8 PF13855.4 NM_001079515.2_3 - 1.3e-10 40.7 12.3 5.5e-05 22.7 0.1 4.8 4 1 2 6 6 6 4 Leucine rich repeat LRR_9 PF14580.4 NM_001079515.2_3 - 1.4e-08 34.3 4.1 7.9e-07 28.6 1.7 3.1 1 1 0 2 2 2 1 Leucine-rich repeat Ubiquitin_2 PF14560.4 NM_001079515.2_3 - 2e-05 24.8 0.1 4e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain LRR_6 PF13516.4 NM_001079515.2_3 - 0.0018 18.1 12.0 15 5.8 0.1 7.0 8 0 0 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.31 NM_001079515.2_3 - 0.74 10.4 10.8 73 4.3 0.0 6.1 6 0 0 6 6 6 0 Leucine Rich Repeat p53-inducible11 PF14936.4 NM_001318387.1_2 - 7.6e-43 146.5 12.3 3.7e-27 95.4 4.1 2.1 1 1 1 2 2 2 2 Tumour protein p53-inducible protein 11 Sod_Fe_C PF02777.16 NM_001322820.1_2 - 9.5e-38 128.3 0.0 1.6e-37 127.7 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.20 NM_001322820.1_2 - 6.9e-32 109.6 3.2 1.3e-31 108.8 3.2 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain TPR_1 PF00515.26 NM_001318533.1_1 - 6e-14 51.1 9.4 1.4e-06 27.7 0.4 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001318533.1_1 - 6.7e-11 41.3 7.3 0.00021 21.0 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001318533.1_1 - 3.1e-07 30.0 7.0 0.0012 18.8 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat HEAT_2 PF13646.4 NM_001318533.1_1 - 0.00017 21.7 1.7 0.1 12.8 0.2 4.7 3 2 1 4 4 4 1 HEAT repeats TPR_12 PF13424.4 NM_001318533.1_1 - 0.00031 20.9 2.4 0.0098 16.0 0.1 3.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001318533.1_1 - 0.0011 19.3 2.4 0.0049 17.2 0.5 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001318533.1_1 - 0.0021 17.5 4.9 0.015 14.9 0.6 3.4 2 2 1 3 3 3 1 TPR repeat Fis1_TPR_C PF14853.4 NM_001318533.1_1 - 0.003 17.4 0.9 0.88 9.6 0.1 2.9 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.4 NM_001318533.1_1 - 0.0035 17.9 0.0 0.44 11.1 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001318533.1_1 - 0.016 15.8 0.0 74 4.4 0.0 4.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001318533.1_1 - 0.033 14.7 1.2 1.6 9.4 0.0 3.6 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001318533.1_1 - 0.098 13.0 0.7 7.3 7.1 0.2 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001318533.1_1 - 0.13 12.3 1.8 2.4 8.3 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat HEAT PF02985.20 NM_001318533.1_1 - 0.7 10.2 7.8 18 5.7 0.1 4.9 5 0 0 5 5 5 0 HEAT repeat V-ATPase_H_C PF11698.6 NM_001318533.1_1 - 0.76 9.8 3.6 5.6 7.0 0.1 3.3 3 0 0 3 3 3 0 V-ATPase subunit H Arm PF00514.21 NM_001318533.1_1 - 4.7 7.3 18.2 4.2 7.4 0.1 6.7 8 0 0 8 8 8 0 Armadillo/beta-catenin-like repeat Filament PF00038.19 NM_001278606.1_2 - 1.1e-05 25.1 21.7 0.0012 18.4 0.8 2.3 2 0 0 2 2 2 2 Intermediate filament protein Spc7 PF08317.9 NM_001278606.1_2 - 0.00053 18.8 10.8 0.00053 18.8 10.8 1.8 2 0 0 2 2 2 1 Spc7 kinetochore protein LemA PF04011.10 NM_001278606.1_2 - 0.0028 17.0 0.9 0.0053 16.1 0.7 1.5 1 1 0 1 1 1 1 LemA family DUF4407 PF14362.4 NM_001278606.1_2 - 0.23 10.6 3.5 0.39 9.9 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4337 PF14235.4 NM_001278606.1_2 - 0.28 11.1 4.8 0.73 9.8 4.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DIT1_PvcA PF05141.10 NM_001278606.1_2 - 0.45 9.8 3.7 0.75 9.1 3.7 1.3 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein Bap31 PF05529.10 NM_001278606.1_2 - 5.1 6.5 9.7 1.5 8.3 5.7 2.0 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like p450 PF00067.20 NM_000767.4_2 - 9.1e-145 482.8 0.0 1.2e-144 482.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 IQ PF00612.25 NM_018136.4_3 - 1.7e-142 450.0 522.2 0.00028 20.3 0.4 71.2 73 0 0 73 73 73 59 IQ calmodulin-binding motif ASH PF15780.3 NM_018136.4_3 - 5.5e-34 116.2 0.0 9.7e-33 112.2 0.0 2.8 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin CH PF00307.29 NM_018136.4_3 - 4.3e-13 49.3 11.0 2.4e-08 34.0 0.0 6.1 6 1 0 6 6 6 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_018136.4_3 - 1.9e-06 27.5 0.0 7.8e-06 25.5 0.0 2.1 1 0 0 1 1 1 1 CAMSAP CH domain DUF5036 PF16439.3 NM_018136.4_3 - 0.083 12.5 1.7 8.8 5.8 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5036) CH_2 PF06294.9 NM_018136.4_3 - 0.34 10.9 0.0 0.34 10.9 0.0 5.0 5 0 0 5 5 5 0 CH-like domain in sperm protein Ceramidase PF05875.10 NM_001010887.2_3 - 5e-55 186.6 13.6 8.6e-55 185.9 13.6 1.3 1 0 0 1 1 1 1 Ceramidase Collagen PF01391.16 NM_001287758.1_1 - 2.9e-186 603.3 633.9 3.9e-10 39.2 16.8 27.0 11 9 13 25 25 25 24 Collagen triple helix repeat (20 copies) C4 PF01413.17 NM_001287758.1_1 - 1.2e-80 267.0 5.1 1.9e-43 147.2 0.2 2.2 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen JAB PF01398.19 NM_001242640.1_1 - 1.6e-45 153.8 1.5 7.8e-44 148.3 1.5 2.4 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 NM_001242640.1_1 - 4.4e-06 26.3 0.1 7.6e-06 25.6 0.1 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.11 NM_001242640.1_1 - 0.053 13.4 0.0 0.14 12.0 0.0 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0172) Ribosomal_L20 PF00453.16 NM_017971.3_1 - 4.8e-36 123.0 3.5 7.4e-36 122.4 3.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L20 Atracotoxin PF05353.9 NM_017971.3_2 - 0.12 12.3 6.0 0.22 11.4 6.0 1.3 1 0 0 1 1 1 0 Delta Atracotoxin Ribosomal_S15 PF00312.20 NM_031280.3_3 - 3.6e-21 75.0 2.2 3.6e-21 75.0 2.2 1.8 2 0 0 2 2 2 1 Ribosomal protein S15 DUF272 PF03312.13 NM_031280.3_3 - 0.059 13.5 0.8 0.11 12.6 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF272) bZIP_Maf PF03131.15 NM_031280.3_3 - 1 9.8 8.0 0.082 13.3 2.3 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor DUF724 PF05266.12 NM_031280.3_3 - 3.7 7.2 10.6 0.18 11.5 5.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Filament PF00038.19 NM_080747.2_3 - 1.1e-103 347.0 30.7 1.3e-103 346.8 30.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 NM_080747.2_3 - 4.1e-16 59.4 32.0 1.1e-15 58.0 3.2 3.2 2 1 1 3 3 3 2 Keratin type II head CENP-F_leu_zip PF10473.7 NM_080747.2_3 - 1.1e-06 28.5 24.6 9.5e-05 22.3 5.1 3.4 2 2 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.4 NM_080747.2_3 - 0.0028 16.3 10.5 0.0028 16.3 10.5 1.6 1 1 0 1 1 1 1 AAA domain Reo_sigmaC PF04582.10 NM_080747.2_3 - 0.0097 15.2 3.6 0.24 10.6 0.2 2.5 1 1 0 2 2 2 1 Reovirus sigma C capsid protein Spc7 PF08317.9 NM_080747.2_3 - 0.021 13.6 29.7 0.01 14.6 5.1 3.4 1 1 3 4 4 4 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 NM_080747.2_3 - 0.026 14.5 0.2 0.026 14.5 0.2 4.0 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein ADIP PF11559.6 NM_080747.2_3 - 0.083 12.8 17.4 0.039 13.9 3.4 3.5 2 2 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF713 PF05218.12 NM_080747.2_3 - 0.14 11.7 0.1 0.14 11.7 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF713) DUF5082 PF16888.3 NM_080747.2_3 - 0.19 12.0 21.1 0.1 12.8 0.5 4.5 1 1 2 4 4 4 0 Domain of unknown function (DUF5082) IncA PF04156.12 NM_080747.2_3 - 0.23 11.1 28.2 0.53 9.9 12.8 3.4 1 1 1 2 2 2 0 IncA protein ATG16 PF08614.9 NM_080747.2_3 - 0.26 11.3 25.3 0.12 12.5 8.9 3.4 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) Alanine_zipper PF11839.6 NM_080747.2_3 - 0.34 11.1 5.3 0.1 12.8 1.6 2.1 2 1 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein DUF1664 PF07889.10 NM_080747.2_3 - 0.63 9.9 16.5 0.071 13.0 1.5 4.0 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 NM_080747.2_3 - 0.87 9.5 14.7 0.25 11.2 1.6 4.0 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF342 PF03961.11 NM_080747.2_3 - 1.1 7.7 16.9 1.2 7.5 3.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF342) KfrA_N PF11740.6 NM_080747.2_3 - 3.7 8.1 11.4 0.084 13.4 2.5 2.6 2 1 1 3 3 3 0 Plasmid replication region DNA-binding N-term Syntaxin-6_N PF09177.9 NM_080747.2_3 - 3.8 8.0 9.1 0.51 10.8 1.0 3.2 1 1 1 3 3 3 0 Syntaxin 6, N-terminal V_ATPase_I PF01496.17 NM_080747.2_3 - 5.4 4.6 12.5 0.21 9.3 0.3 2.4 2 1 0 2 2 2 0 V-type ATPase 116kDa subunit family CLZ PF16526.3 NM_080747.2_3 - 5.7 7.2 11.9 1.3 9.3 1.5 4.0 3 2 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Lebercilin PF15619.4 NM_080747.2_3 - 6.6 6.2 25.4 4 6.9 7.7 2.4 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Ion_trans PF00520.29 NM_001260497.1_1 - 2.3e-43 148.1 14.7 3.7e-43 147.4 14.7 1.3 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_001260497.1_1 - 3e-22 78.7 0.0 2e-21 76.0 0.0 2.3 1 1 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_001260497.1_1 - 2.4e-10 40.1 2.8 2.4e-10 40.1 2.8 2.6 2 0 0 2 2 2 1 Ion channel Aldedh PF00171.20 NM_001290058.1_3 - 1.7e-50 171.7 0.0 2e-25 89.1 0.0 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family PMP22_Claudin PF00822.18 NM_001146077.1_1 - 8.8e-29 100.4 10.0 1.2e-28 99.9 10.0 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001146077.1_1 - 4.4e-05 23.2 13.7 0.00015 21.4 11.4 2.2 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.9 NM_001146077.1_1 - 0.13 12.0 8.3 0.24 11.1 7.9 1.8 1 1 0 1 1 1 0 Amastin surface glycoprotein Guanylate_kin PF00625.19 NM_001098424.1_2 - 2.1e-66 223.0 1.5 3.4e-66 222.3 1.5 1.4 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 NM_001098424.1_2 - 5.1e-62 206.1 8.7 6.6e-20 71.1 0.3 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) MAGUK_N_PEST PF10608.7 NM_001098424.1_2 - 4.7e-60 201.1 8.5 1.1e-59 200.0 8.5 1.6 1 0 0 1 1 1 1 Polyubiquitination (PEST) N-terminal domain of MAGUK L27_1 PF09058.8 NM_001098424.1_2 - 1.5e-29 101.7 4.3 3.5e-29 100.5 4.3 1.7 1 0 0 1 1 1 1 L27_1 PDZ_assoc PF10600.7 NM_001098424.1_2 - 3.3e-24 85.4 4.2 1e-23 83.8 4.2 1.9 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 NM_001098424.1_2 - 3.2e-16 59.3 0.9 0.00026 21.1 0.1 3.7 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.15 NM_001098424.1_2 - 4e-08 32.7 0.0 9e-08 31.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001098424.1_2 - 4.6e-08 32.4 0.1 1.1e-07 31.1 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001098424.1_2 - 0.026 14.2 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain DUF2477 PF10631.7 NM_001098424.1_3 - 8.7 6.9 12.5 15 6.1 12.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) Nucleoside_tran PF01733.16 NM_001174098.1_1 - 1.2e-60 205.4 6.6 1.2e-60 205.4 6.6 2.1 1 1 1 2 2 2 2 Nucleoside transporter YiaAB PF05360.12 NM_001174098.1_1 - 7.2 6.8 9.8 1.1 9.5 3.4 2.6 2 0 0 2 2 2 0 yiaA/B two helix domain SR-25 PF10500.7 NM_018694.3_2 - 2.7e-102 341.0 48.8 3.5e-102 340.7 48.8 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.7 NM_018694.3_2 - 0.12 10.8 19.8 0.16 10.4 19.8 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF936 PF06075.10 NM_018694.3_2 - 7.5 5.2 30.8 9.4 4.9 30.8 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) NHR2 PF08788.9 NM_001198626.1_1 - 3.9e-39 132.1 8.8 8.2e-39 131.1 8.8 1.6 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 NM_001198626.1_1 - 7.7e-34 115.5 1.6 1.3e-33 114.8 1.6 1.4 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.16 NM_001198626.1_1 - 3.7e-07 30.0 18.2 1.4e-06 28.1 18.2 2.1 1 0 0 1 1 1 1 MYND finger DUF3731 PF12531.6 NM_001198626.1_1 - 0.081 12.6 0.8 0.14 11.8 0.8 1.2 1 0 0 1 1 1 0 DNA-K related protein Efg1 PF10153.7 NM_001198626.1_1 - 0.18 12.1 1.9 0.39 11.0 1.9 1.5 1 0 0 1 1 1 0 rRNA-processing protein Efg1 vATP-synt_E PF01991.16 NM_001198626.1_1 - 6.1 6.1 11.1 9.4 5.4 11.1 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit DUF4486 PF14858.4 NM_001306084.1_1 - 7.2e-279 925.7 11.1 7.2e-279 925.7 11.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4486) LNS2 PF08235.11 NM_001306084.1_1 - 0.026 13.9 0.1 0.33 10.2 0.0 2.4 2 0 0 2 2 2 0 LNS2 (Lipin/Ned1/Smp2) Trypsin PF00089.24 NM_001167605.1_1 - 5.2e-67 225.8 0.9 1.4e-66 224.3 0.9 1.6 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_001167605.1_1 - 0.0038 18.0 0.0 0.0071 17.1 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_001167605.1_1 - 0.076 13.3 0.1 2.3 8.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1986) RIO1 PF01163.20 NM_001159749.1_3 - 3.2e-55 186.5 1.0 5.1e-55 185.8 1.0 1.2 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.9 NM_001159749.1_3 - 1.5e-32 111.5 0.1 3.7e-32 110.2 0.1 1.7 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.21 NM_001159749.1_3 - 6.2e-09 36.0 1.3 9.6e-05 22.3 0.3 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 NM_001159749.1_3 - 5.1e-08 32.4 2.1 1.5e-06 27.6 2.1 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-H2C2_2 PF13465.4 NM_198089.2_3 - 2.4e-75 245.7 95.3 3.8e-08 33.3 1.8 14.2 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_198089.2_3 - 7.7e-47 155.1 103.1 1.1e-05 25.5 1.8 14.1 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_198089.2_3 - 2.1e-26 90.2 96.3 0.0013 19.3 0.8 14.1 14 0 0 14 14 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_198089.2_3 - 2.2e-23 81.5 0.1 6.5e-23 80.0 0.1 1.9 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_198089.2_3 - 2.7e-15 56.1 61.3 0.0048 17.1 0.2 12.0 13 0 0 13 13 13 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_198089.2_3 - 2.2e-08 33.7 81.1 0.031 14.1 0.6 12.6 13 0 0 13 13 13 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_198089.2_3 - 9.5e-07 28.7 68.5 0.054 13.5 1.4 9.7 3 3 7 11 11 11 6 Zinc ribbon domain zf-met PF12874.5 NM_198089.2_3 - 0.00036 20.7 79.3 0.051 13.8 1.3 11.6 13 0 0 13 13 13 5 Zinc-finger of C2H2 type DUF3268 PF11672.6 NM_198089.2_3 - 0.00051 20.2 38.7 0.087 13.0 0.2 6.5 5 1 0 6 6 6 3 zinc-finger-containing domain BolA PF01722.16 NM_198089.2_3 - 0.021 15.0 15.0 1.9 8.7 0.2 4.6 3 2 2 5 5 5 0 BolA-like protein ADK_lid PF05191.12 NM_198089.2_3 - 0.023 14.6 57.5 0.044 13.7 0.5 9.8 8 2 0 8 8 8 0 Adenylate kinase, active site lid XPA_N PF01286.16 NM_198089.2_3 - 0.38 10.7 66.3 6.6 6.7 0.4 13.2 13 0 0 13 13 13 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_198089.2_3 - 0.95 10.1 54.3 1.2 9.8 1.5 7.4 1 1 5 7 7 7 0 zinc-ribbon family zf-trcl PF13451.4 NM_198089.2_3 - 7.7 6.4 68.5 2.3 8.1 0.4 12.0 9 4 0 9 9 9 0 Probable zinc-ribbon domain Mei4 PF13971.4 NM_001322247.1_3 - 5.6e-97 325.2 8.1 7.7e-97 324.7 8.1 1.1 1 0 0 1 1 1 1 Meiosis-specific protein Mei4 SelK_SelG PF10961.6 NM_001323347.1_1 - 0.13 12.8 0.3 1.2 9.6 0.0 2.7 2 0 0 2 2 2 0 Selenoprotein SelK_SelG Hep_59 PF07052.9 NM_001323347.1_1 - 0.18 12.4 0.1 0.18 12.4 0.1 3.3 4 0 0 4 4 4 0 Hepatocellular carcinoma-associated antigen 59 FAM70 PF14967.4 NM_001104544.1_3 - 3.8e-157 522.8 2.8 6.2e-157 522.1 2.8 1.3 1 0 0 1 1 1 1 FAM70 protein DUF4064 PF13273.4 NM_001104544.1_3 - 0.0047 17.1 10.2 0.086 13.1 6.2 3.1 2 1 0 2 2 2 2 Protein of unknown function (DUF4064) Phage_holin_3_2 PF04550.10 NM_001104544.1_3 - 0.19 12.0 3.6 0.093 13.0 1.2 1.7 2 0 0 2 2 2 0 Phage holin family 2 zf-MYND PF01753.16 NM_144781.2_1 - 4e-08 33.1 15.0 4e-08 33.1 15.0 2.0 2 0 0 2 2 2 1 MYND finger BTB PF00651.29 NM_014872.2_3 - 1.3e-28 99.3 1.1 2.4e-28 98.5 1.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 NM_014872.2_3 - 5.4e-07 29.6 13.3 7.9e-07 29.1 2.8 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_014872.2_3 - 0.00091 19.7 13.9 0.29 11.9 4.5 3.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_014872.2_3 - 0.015 15.6 2.4 0.015 15.6 2.4 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF3342 PF11822.6 NM_014872.2_3 - 0.031 14.3 0.2 0.057 13.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) zf-H2C2_2 PF13465.4 NM_001277949.1_1 - 5.1e-98 317.4 135.8 6.4e-08 32.6 1.1 19.1 20 0 0 20 20 20 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001277949.1_1 - 2.7e-71 232.1 150.0 3.1e-06 27.2 0.5 17.9 19 0 0 19 19 17 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001277949.1_1 - 2.2e-40 133.7 120.9 0.0026 18.3 1.6 16.5 16 0 0 16 16 16 14 C2H2-type zinc finger KRAB PF01352.25 NM_001277949.1_1 - 2.6e-27 94.1 0.2 7.3e-27 92.6 0.1 1.9 2 0 0 2 2 2 1 KRAB box zf-C2H2_6 PF13912.4 NM_001277949.1_1 - 3.3e-18 65.1 120.8 0.14 12.0 0.4 18.2 17 4 0 17 17 17 14 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001277949.1_1 - 1.4e-15 57.0 78.6 0.0094 15.9 3.1 13.6 6 5 10 16 16 16 13 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001277949.1_1 - 5.1e-11 42.4 77.7 0.089 13.0 0.7 14.3 14 0 0 14 14 14 6 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001277949.1_1 - 2.4e-10 40.1 52.6 2.2 8.3 0.1 15.0 16 0 0 16 16 16 3 XPA protein N-terminal C1_1 PF00130.20 NM_001277949.1_1 - 3.2e-10 39.6 72.3 0.066 13.0 3.9 10.5 5 3 6 13 13 12 9 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.3 NM_001277949.1_1 - 7e-09 36.2 60.2 0.046 14.3 1.4 8.3 1 1 7 8 8 8 6 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_001277949.1_1 - 8.3e-06 25.3 72.0 0.4 10.3 0.1 14.7 17 0 0 17 17 17 5 zinc-finger C2H2-type Zf_RING PF16744.3 NM_001277949.1_1 - 0.00083 19.3 53.3 0.43 10.6 0.6 13.0 1 1 13 14 14 14 3 KIAA1045 RING finger MRP-S23 PF10484.7 NM_001277949.1_1 - 0.0014 18.7 0.0 88 3.2 0.0 6.7 1 1 8 9 9 9 0 Mitochondrial ribosomal protein S23 Arc_trans_TRASH PF08394.8 NM_001277949.1_1 - 0.0031 17.7 19.4 23 5.3 0.1 10.2 12 1 1 13 13 13 0 Archaeal TRASH domain zf-met PF12874.5 NM_001277949.1_1 - 0.014 15.6 0.5 0.014 15.6 0.5 13.6 14 0 0 14 14 13 0 Zinc-finger of C2H2 type ZZ PF00569.15 NM_001277949.1_1 - 0.021 14.5 65.0 20 5.0 0.2 14.8 14 0 0 14 14 14 0 Zinc finger, ZZ type BolA PF01722.16 NM_001277949.1_1 - 0.15 12.3 34.5 0.63 10.2 0.2 7.2 4 2 3 8 8 8 0 BolA-like protein zf-BED PF02892.13 NM_001277949.1_1 - 0.69 9.9 98.1 0.087 12.8 2.4 14.1 1 1 12 13 13 13 0 BED zinc finger zf-C2HE PF16278.3 NM_001277949.1_1 - 1.1 9.6 88.2 0.42 11.0 0.7 13.9 2 2 11 13 13 13 0 C2HE / C2H2 / C2HC zinc-binding finger COX5B PF01215.17 NM_001277949.1_1 - 1.8 8.2 41.9 9.5 5.8 0.2 11.0 2 2 10 12 12 12 0 Cytochrome c oxidase subunit Vb Zn_Tnp_IS1595 PF12760.5 NM_001277949.1_1 - 2.8 7.8 73.7 3.5 7.5 4.5 12.0 8 4 5 13 13 13 0 Transposase zinc-ribbon domain YhfH PF14149.4 NM_001277949.1_1 - 4.3 7.3 67.5 9.6 6.1 0.2 14.7 15 0 0 15 15 15 0 YhfH-like protein CS PF04969.14 NM_001277949.1_2 - 0.00032 21.5 3.7 8.6 7.3 0.4 4.3 3 0 0 3 3 3 3 CS domain KRAB PF01352.25 NM_001277949.1_3 - 6.8e-23 79.9 0.0 1.1e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 KRAB box Mut7-C PF01927.14 NM_001277949.1_3 - 0.33 10.9 3.5 0.31 11.0 0.3 2.5 3 0 0 3 3 3 0 Mut7-C RNAse domain MyTH4 PF00784.15 NM_024927.4_3 - 5.9e-21 74.8 0.0 1.2e-20 73.8 0.0 1.5 1 0 0 1 1 1 1 MyTH4 domain FERM_M PF00373.16 NM_024927.4_3 - 3.7e-07 30.4 0.0 2e-06 28.1 0.0 2.0 1 1 0 1 1 1 1 FERM central domain RA PF00788.21 NM_024927.4_3 - 6.3e-05 23.4 0.0 0.00013 22.4 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 NM_024927.4_3 - 0.0013 19.1 0.0 0.0023 18.3 0.0 1.5 1 0 0 1 1 1 1 PH domain zf-RING_4 PF14570.4 NM_001008225.2_2 - 1.4e-19 69.4 12.2 1.4e-19 69.4 12.2 1.8 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.4 NM_001008225.2_2 - 4.8e-06 26.2 7.4 4.8e-06 26.2 7.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.20 NM_001008225.2_2 - 1.7e-05 24.4 0.0 3.7e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-UDP PF14569.4 NM_001008225.2_2 - 0.051 13.6 3.1 0.12 12.3 3.1 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4 PF00097.23 NM_001008225.2_2 - 1.1 9.1 17.1 0.12 12.1 9.9 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ubiquitin PF00240.21 NM_031434.3_3 - 2.4e-07 30.2 0.0 3.7e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.4 NM_031434.3_3 - 0.0014 18.6 0.0 0.0023 17.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ocnus PF05005.13 NM_014172.5_1 - 1.8e-40 137.2 0.2 2.8e-40 136.6 0.2 1.3 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) G-alpha PF00503.18 NM_002069.5_2 - 9.9e-125 416.2 2.2 1.2e-124 415.9 2.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 NM_002069.5_2 - 1.4e-16 60.4 0.2 2.2e-12 46.6 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_002069.5_2 - 0.00053 19.3 2.1 0.036 13.3 0.5 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 NM_002069.5_2 - 0.0029 17.7 0.2 3 8.0 0.1 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Osteoregulin PF07175.9 NM_020203.3_2 - 2.7e-88 294.1 6.3 2.7e-88 294.1 6.3 2.7 3 0 0 3 3 3 1 Osteoregulin Maelstrom PF13017.4 NM_001286377.1_1 - 4.7e-58 196.3 0.6 7e-58 195.7 0.6 1.2 1 0 0 1 1 1 1 piRNA pathway germ-plasm component HMG_box_2 PF09011.8 NM_001286377.1_1 - 4.4e-14 52.7 0.0 8.1e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain GST_N PF02798.18 NM_001142368.1_2 - 4.1e-22 78.2 0.1 9.7e-22 77.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 NM_001142368.1_2 - 1.1e-16 60.6 0.1 1.8e-16 60.0 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_001142368.1_2 - 5.5e-12 45.6 0.0 1.1e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 NM_001142368.1_2 - 5.2e-05 22.8 0.1 0.00016 21.3 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 NM_001142368.1_2 - 0.00036 20.3 0.0 0.00066 19.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 NM_001142368.1_2 - 0.0094 16.2 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF4414 PF14377.4 NM_001142368.1_2 - 0.1 12.7 0.1 0.17 12.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4414) Ig_2 PF13895.4 NM_001206650.1_1 - 5.6e-31 106.6 7.7 6.5e-16 58.3 0.4 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 NM_001206650.1_1 - 2.2e-27 95.3 7.9 2e-09 37.8 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_001206650.1_1 - 2.8e-16 59.3 2.0 0.00033 20.6 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_001206650.1_1 - 1.3e-14 53.9 0.0 0.0024 17.8 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_5 PF16681.3 NM_001206650.1_1 - 2.1e-05 24.7 0.1 0.013 15.7 0.0 3.2 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.15 NM_001206650.1_1 - 0.00038 20.4 5.6 0.092 12.8 0.1 4.3 2 2 1 3 3 3 2 Immunoglobulin V-set domain C2-set PF05790.13 NM_001206650.1_1 - 0.0035 17.4 0.0 3.6 7.7 0.1 3.5 3 0 0 3 3 3 1 Immunoglobulin C2-set domain Lep_receptor_Ig PF06328.9 NM_001206650.1_1 - 0.0066 16.3 0.1 1 9.3 0.0 3.2 3 0 0 3 3 3 1 Ig-like C2-type domain Izumo-Ig PF16706.3 NM_001206650.1_1 - 0.042 13.8 0.0 9.3 6.2 0.0 3.1 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Cornichon PF03311.12 NM_001322304.1_3 - 1.9e-26 92.6 4.3 6.1e-26 91.0 4.3 1.8 1 1 0 1 1 1 1 Cornichon protein Myosin_tail_1 PF01576.17 NM_024729.3_3 - 0 1509.4 275.8 0 1509.2 275.8 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 NM_024729.3_3 - 1.4e-287 955.3 0.0 2.6e-287 954.5 0.0 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) ADIP PF11559.6 NM_024729.3_3 - 2.2e-06 27.7 15.4 2.2e-06 27.7 15.4 13.5 2 2 8 13 13 13 1 Afadin- and alpha -actinin-Binding Myosin_N PF02736.17 NM_024729.3_3 - 6.6e-05 22.5 0.0 0.00013 21.5 0.0 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 NM_024729.3_3 - 0.00094 18.6 0.3 0.0033 16.9 0.3 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_22 PF13401.4 NM_024729.3_3 - 0.13 12.4 0.0 0.13 12.4 0.0 5.3 4 1 0 4 4 4 0 AAA domain PLDc_2 PF13091.4 NM_178836.3_2 - 1.7e-26 92.5 0.0 2.4e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 PLD-like domain PLDc PF00614.20 NM_178836.3_2 - 0.00091 19.2 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 Phospholipase D Active site motif DUF1669 PF07894.10 NM_178836.3_2 - 0.023 14.1 0.1 0.052 13.0 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1669) DUF3808 PF10300.7 NM_001297665.1_3 - 2.2e-156 521.2 12.2 4e-124 414.8 0.6 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF3808) TPR_12 PF13424.4 NM_001297665.1_3 - 3.1e-07 30.5 3.8 2.1e-05 24.6 0.8 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001297665.1_3 - 5.4e-06 26.9 0.1 0.12 13.0 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001297665.1_3 - 2.4e-05 24.0 5.9 0.23 11.5 0.9 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001297665.1_3 - 0.00036 20.4 1.6 4.6 7.6 0.5 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001297665.1_3 - 0.00046 20.6 0.5 0.14 12.9 0.1 3.9 4 1 1 5 5 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001297665.1_3 - 0.00097 19.5 2.8 0.45 10.9 1.9 4.5 5 1 1 6 6 6 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.8 NM_001297665.1_3 - 0.005 16.4 0.0 0.31 10.5 0.0 2.7 2 1 1 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_1 PF00515.26 NM_001297665.1_3 - 0.0087 15.7 5.1 2.4 8.0 1.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat ROK PF00480.18 NM_001297665.1_3 - 0.019 14.3 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 ROK family TPR_6 PF13174.4 NM_001297665.1_3 - 0.058 13.9 5.0 0.11 13.0 0.7 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001297665.1_3 - 0.58 10.0 5.1 2.4 8.1 0.8 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001297665.1_3 - 5.4 7.2 15.7 3.9 7.6 0.1 4.7 5 1 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Transposase_22 PF02994.12 NM_019079.4_1 - 1.1e-79 267.9 17.9 7.6e-61 205.9 14.2 3.7 3 1 1 4 4 4 2 L1 transposable element HSBP1 PF06825.10 NM_019079.4_1 - 0.042 13.6 2.9 0.2 11.5 2.9 2.2 1 0 0 1 1 1 0 Heat shock factor binding protein 1 PDEase_I PF00233.17 NM_019079.4_1 - 0.079 12.5 4.1 1.1 8.8 1.1 2.6 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase DIRP PF06584.11 NM_001270410.1_3 - 5.3e-47 158.2 0.2 1.1e-46 157.2 0.2 1.6 1 0 0 1 1 1 1 DIRP FTA4 PF13093.4 NM_001270410.1_3 - 0.026 14.3 0.2 0.061 13.1 0.2 1.6 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF2664 PF10867.6 NM_001270410.1_3 - 0.064 13.6 0.8 0.17 12.2 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2664) SAM_1 PF00536.28 NM_001256569.1_1 - 1.4e-39 134.2 5.5 2.8e-17 62.8 0.0 3.8 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001256569.1_1 - 1.4e-39 133.9 0.8 5.5e-16 58.3 0.0 3.5 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) Atg14 PF10186.7 NM_001256569.1_1 - 0.0044 16.0 11.9 0.0067 15.4 11.9 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Reo_sigmaC PF04582.10 NM_001256569.1_1 - 0.061 12.6 1.1 0.096 11.9 1.1 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF812 PF05667.9 NM_001256569.1_1 - 0.11 11.2 18.3 0.17 10.6 18.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) FxsA PF04186.11 NM_001256569.1_1 - 0.17 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 FxsA cytoplasmic membrane protein SAM_PNT PF02198.14 NM_001256569.1_1 - 0.7 9.8 4.4 14 5.6 0.0 3.4 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain ERM PF00769.17 NM_001256569.1_1 - 1.7 8.3 31.0 4.9 6.8 31.0 1.8 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF641 PF04859.10 NM_001256569.1_1 - 5.6 7.2 16.6 4.6 7.5 13.1 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Spc7 PF08317.9 NM_001256569.1_1 - 6.1 5.5 24.5 9.5 4.9 24.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4613 PF15390.4 NM_001256569.1_1 - 8 4.5 12.4 12 4.0 12.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Phage_GPO PF05929.9 NM_001256569.1_1 - 8.2 5.9 9.7 14 5.1 9.7 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase HMMR_N PF15905.3 NM_001256569.1_1 - 8.3 5.6 29.4 34 3.6 29.2 1.8 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal TMEM61 PF15105.4 NM_182532.2_1 - 3.3e-106 353.1 8.0 5.8e-106 352.3 8.0 1.4 1 0 0 1 1 1 1 TMEM61 protein family Mtp PF03821.14 NM_182532.2_1 - 0.036 13.6 0.7 0.052 13.0 0.7 1.2 1 0 0 1 1 1 0 Golgi 4-transmembrane spanning transporter PQ-loop PF04193.12 NM_001282711.1_2 - 3.6e-06 26.5 0.3 6.1e-06 25.8 0.3 1.4 1 0 0 1 1 1 1 PQ loop repeat Filament PF00038.19 NM_033033.3_2 - 6.3e-98 328.1 23.2 7.5e-98 327.8 23.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 NM_033033.3_2 - 1e-11 45.2 13.2 1.1e-10 41.8 0.2 2.8 2 1 1 3 3 3 2 Keratin type II head TPR_MLP1_2 PF07926.10 NM_033033.3_2 - 0.0018 18.2 20.4 0.037 14.0 0.1 3.1 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein ComX PF05952.10 NM_033033.3_2 - 0.22 11.6 0.6 2.1 8.5 0.1 2.3 2 0 0 2 2 2 0 Bacillus competence pheromone ComX TMF_TATA_bd PF12325.6 NM_033033.3_2 - 0.23 11.6 12.3 0.74 9.9 0.3 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding HIP1_clath_bdg PF16515.3 NM_033033.3_2 - 0.75 10.3 9.2 0.24 11.9 5.6 2.1 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CHDCT2 PF08074.9 NM_033033.3_2 - 0.83 9.7 5.7 0.69 9.9 0.4 2.3 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain DUF4472 PF14739.4 NM_033033.3_2 - 2 9.0 11.3 15 6.3 6.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4472) DivIVA PF05103.11 NM_033033.3_2 - 3 7.8 8.7 8.6 6.3 8.5 1.9 1 1 0 1 1 1 0 DivIVA protein BRE1 PF08647.9 NM_033033.3_2 - 3.6 7.6 15.3 0.095 12.7 1.3 3.2 2 2 1 3 3 3 0 BRE1 E3 ubiquitin ligase DUF5082 PF16888.3 NM_033033.3_2 - 3.8 7.8 12.7 1.5 9.0 0.8 3.5 2 2 1 3 3 3 0 Domain of unknown function (DUF5082) Spc24 PF08286.9 NM_033033.3_2 - 7.1 6.8 7.1 2.2 8.5 1.6 2.7 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 Ank_2 PF12796.5 NM_001290258.1_2 - 1.8e-53 178.9 15.7 3.8e-11 43.3 0.0 5.9 1 1 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001290258.1_2 - 3.7e-41 138.9 1.4 1.1e-08 35.3 0.0 7.2 7 0 0 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001290258.1_2 - 9.2e-37 120.8 6.2 0.0014 18.8 0.4 11.0 11 0 0 11 11 11 8 Ankyrin repeat Ank_5 PF13857.4 NM_001290258.1_2 - 2.7e-28 97.4 11.0 6.9e-06 26.2 0.2 8.7 2 1 8 10 10 10 9 Ankyrin repeats (many copies) Ank PF00023.28 NM_001290258.1_2 - 2.3e-26 90.9 13.5 0.011 16.1 0.1 10.1 10 0 0 10 10 10 8 Ankyrin repeat SOCS_box PF07525.14 NM_001290258.1_2 - 3.9e-11 43.0 6.9 3.9e-11 43.0 6.9 2.6 2 0 0 2 2 2 1 SOCS box ACBP PF00887.17 NM_024722.3_1 - 3.4e-26 91.2 0.1 1.1e-25 89.6 0.1 1.9 2 0 0 2 2 2 1 Acyl CoA binding protein Mito_carr PF00153.25 NM_213611.2_1 - 5.1e-48 160.8 7.5 1e-18 66.9 0.1 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein DSPc PF00782.18 NM_016086.2_2 - 8.7e-23 80.5 0.0 1.3e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.18 NM_016086.2_2 - 1.7e-07 31.6 0.0 6.1e-07 29.8 0.0 1.9 1 1 0 1 1 1 1 Rhodanese-like domain TPR_2 PF07719.15 NM_022492.4_3 - 8.3e-13 47.3 0.4 0.0029 17.5 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.4 NM_022492.4_3 - 4.2e-09 36.8 1.3 0.00043 20.8 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_022492.4_3 - 1.5e-07 30.8 0.0 0.035 13.8 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_022492.4_3 - 9.6e-05 22.8 1.4 0.23 12.2 0.0 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_022492.4_3 - 0.0011 18.9 0.0 1.9 8.8 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_022492.4_3 - 0.0021 18.4 0.0 0.12 12.8 0.0 2.5 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.4 NM_022492.4_3 - 0.045 13.7 0.0 4.1 7.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.4 NM_022492.4_3 - 0.054 13.1 0.0 0.51 9.9 0.0 2.5 2 0 0 2 2 2 0 TPR repeat TPR_12 PF13424.4 NM_022492.4_3 - 0.11 12.7 1.0 11 6.3 0.1 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.4 NM_022492.4_3 - 0.32 11.1 5.8 0.5 10.4 0.1 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat SCAMP PF04144.11 NM_005697.4_2 - 8.8e-70 234.4 15.6 1.2e-69 233.9 15.6 1.2 1 0 0 1 1 1 1 SCAMP family DUF996 PF06195.11 NM_005697.4_2 - 0.042 14.0 1.6 0.074 13.2 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF996) DUF3552 PF12072.6 NM_005697.4_2 - 0.081 12.2 1.6 0.13 11.6 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) KfrA_N PF11740.6 NM_005697.4_2 - 0.17 12.5 3.0 0.32 11.6 3.0 1.4 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term Acetyltransf_16 PF05301.9 NM_001031722.3_1 - 1.3e-73 246.3 0.0 5.8e-73 244.2 0.0 1.8 2 0 0 2 2 2 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.5 NM_001031722.3_1 - 0.0045 17.3 0.0 0.0087 16.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 NM_001031722.3_1 - 0.011 15.8 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 NM_001031722.3_1 - 0.15 11.9 0.1 0.29 10.9 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DnaJ PF00226.29 NM_024902.3_2 - 1.3e-16 60.3 0.1 2.2e-16 59.6 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain TM2 PF05154.14 NM_024902.3_2 - 4.7e-07 29.9 10.8 1.2e-06 28.6 10.8 1.8 1 0 0 1 1 1 1 TM2 domain HMG_box PF00505.17 NM_003079.4_2 - 2.4e-18 66.2 1.7 7.4e-18 64.6 1.7 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_003079.4_2 - 1.1e-05 25.8 0.6 1.1e-05 25.8 0.6 2.0 2 0 0 2 2 2 1 HMG-box domain GCN5L1 PF06320.11 NM_003079.4_2 - 1.1 9.3 16.7 0.02 14.9 5.0 2.5 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) CUB PF00431.18 NM_178181.2_1 - 0.0013 18.9 0.0 0.012 15.8 0.0 2.1 2 0 0 2 2 2 1 CUB domain A_deaminase PF00962.20 NM_001025390.1_1 - 2.4e-136 454.2 0.0 4.4e-136 453.4 0.0 1.4 1 1 0 1 1 1 1 Adenosine/AMP deaminase E2F_CC-MB PF16421.3 NM_001278278.1_1 - 1.3e-31 108.7 0.5 2e-31 108.2 0.5 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.18 NM_001278278.1_1 - 8.3e-23 80.1 0.1 1.5e-22 79.3 0.1 1.4 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.17 NM_001278278.1_1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB SWIB PF02201.16 NM_001278516.1_2 - 2.2e-05 24.1 0.0 3.9e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain zf-C3HC4_3 PF13920.4 NM_001278516.1_3 - 1.2e-10 40.9 4.4 1.2e-10 40.9 4.4 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RanBP PF00641.16 NM_001278516.1_3 - 2.2e-08 33.1 6.2 6.5e-08 31.6 6.2 1.9 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Prok-RING_4 PF14447.4 NM_001278516.1_3 - 0.0073 16.0 5.1 0.027 14.2 5.1 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Cript PF10235.7 NM_001278516.1_3 - 0.4 11.1 4.4 0.083 13.3 0.4 1.8 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT DZR PF12773.5 NM_001278516.1_3 - 4.1 7.4 11.7 3.6 7.5 0.6 2.8 2 0 0 2 2 2 0 Double zinc ribbon FKBP_C PF00254.26 NM_002014.3_1 - 5.5e-47 157.9 0.0 3e-30 104.3 0.0 2.9 3 0 0 3 3 3 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.26 NM_002014.3_1 - 1.1e-18 66.0 5.9 6.5e-07 28.8 0.2 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 NM_002014.3_1 - 6.2e-15 53.9 6.1 5.8e-06 25.9 0.1 3.8 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_002014.3_1 - 1.5e-09 37.2 5.1 0.0021 18.0 0.2 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_002014.3_1 - 1.9e-07 31.2 3.1 0.002 18.3 1.5 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.4 NM_002014.3_1 - 8.1e-07 28.5 4.3 0.015 14.8 0.0 3.3 2 1 1 3 3 3 2 TPR repeat TPR_6 PF13174.4 NM_002014.3_1 - 5e-06 26.7 4.3 0.0033 17.8 0.0 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_002014.3_1 - 8.2e-06 26.3 1.5 0.24 12.0 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_002014.3_1 - 1.2e-05 25.6 3.9 0.039 14.3 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_002014.3_1 - 0.00011 22.5 0.2 0.03 15.0 0.1 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.4 NM_002014.3_1 - 0.00072 19.5 0.3 0.0055 16.7 0.4 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.4 NM_002014.3_1 - 0.003 17.3 1.8 0.8 9.8 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat PknG_TPR PF16918.3 NM_002014.3_1 - 0.0046 15.6 0.8 0.0069 15.0 0.8 1.2 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat TPR_17 PF13431.4 NM_002014.3_1 - 0.0048 17.1 1.1 0.82 10.1 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat OmpH PF03938.12 NM_002014.3_1 - 0.012 15.5 5.9 0.022 14.6 5.9 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Fis1_TPR_C PF14853.4 NM_002014.3_1 - 0.13 12.3 1.5 7.7 6.5 0.1 2.7 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.5 NM_002014.3_1 - 0.97 9.5 7.0 17 5.5 0.1 2.7 1 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 PNMA PF14893.4 NM_032882.5_1 - 3.5e-118 394.6 2.0 4.9e-118 394.2 2.0 1.2 1 0 0 1 1 1 1 PNMA Kinesin PF00225.21 NM_022342.4_2 - 1.5e-96 323.1 0.3 2.3e-96 322.5 0.3 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 NM_022342.4_2 - 1.1e-24 86.9 0.0 3.2e-24 85.4 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding AAA_22 PF13401.4 NM_022342.4_2 - 0.04 14.0 2.2 0.32 11.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.4 NM_022342.4_2 - 0.052 13.1 0.1 0.36 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Prismane PF03063.18 NM_022342.4_2 - 0.099 11.2 0.1 0.18 10.3 0.1 1.3 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family ResIII PF04851.13 NM_022342.4_2 - 0.25 11.2 0.0 0.25 11.2 0.0 3.0 3 1 1 4 4 4 0 Type III restriction enzyme, res subunit Laminin_II PF06009.10 NM_022342.4_2 - 0.7 9.8 8.4 1 9.2 3.9 2.5 2 0 0 2 2 2 0 Laminin Domain II Pkinase PF00069.23 NM_006254.3_3 - 3.6e-61 206.7 0.0 5e-61 206.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_006254.3_3 - 1.5e-38 132.4 0.0 3e-38 131.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 NM_006254.3_3 - 4.4e-32 109.6 20.9 1.8e-17 62.8 7.6 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 NM_006254.3_3 - 5e-09 36.6 0.8 9.8e-09 35.6 0.8 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_006254.3_3 - 0.0011 18.2 0.0 0.0022 17.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like C1_2 PF03107.14 NM_006254.3_3 - 0.0017 18.5 3.1 0.0017 18.5 3.1 3.3 4 0 0 4 4 3 2 C1 domain zf-RING-like PF08746.9 NM_006254.3_3 - 0.0021 18.2 18.7 0.058 13.6 6.7 2.9 2 0 0 2 2 2 2 RING-like domain Zf_RING PF16744.3 NM_006254.3_3 - 0.0039 17.1 1.4 0.0039 17.1 1.4 2.6 2 0 0 2 2 2 1 KIAA1045 RING finger zf-RING_9 PF13901.4 NM_006254.3_3 - 0.045 13.6 13.5 0.27 11.0 4.0 2.5 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon FYVE_2 PF02318.14 NM_006254.3_3 - 0.44 10.6 9.6 0.69 10.0 1.6 2.6 2 0 0 2 2 2 0 FYVE-type zinc finger Prok-RING_1 PF14446.4 NM_006254.3_3 - 0.7 9.7 12.6 2.6 7.9 2.9 2.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD PF00628.27 NM_006254.3_3 - 1.6 8.6 23.3 0.1 12.4 3.1 3.0 3 0 0 3 3 3 0 PHD-finger DUF2318 PF10080.7 NM_006254.3_3 - 1.7 8.7 14.3 0.8 9.7 4.8 2.4 1 1 0 2 2 2 0 Predicted membrane protein (DUF2318) PADR1 PF08063.10 NM_006254.3_3 - 8.4 6.1 12.0 0.089 12.4 3.1 2.3 2 0 0 2 2 2 0 PADR1 (NUC008) domain TMEM135_C_rich PF15982.3 NM_022918.3_2 - 2.8e-73 244.6 0.7 2.8e-73 244.6 0.7 1.8 2 0 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 Tim17 PF02466.17 NM_022918.3_2 - 1.8e-08 34.5 0.2 9.4e-07 29.0 0.1 2.4 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family RRM_1 PF00076.20 NM_001144924.1_3 - 9.3e-08 31.7 0.0 0.0047 16.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.22 NM_001144924.1_3 - 1.5e-07 32.0 0.0 4.3e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Exonuclease NIF PF03031.16 NM_001143775.1_3 - 9e-53 178.1 0.0 1.1e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Asparaginase_2 PF01112.16 NM_001323602.1_1 - 3.4e-26 91.9 7.8 4.6e-21 75.0 1.4 2.2 1 1 1 2 2 2 2 Asparaginase I-set PF07679.14 NM_001007156.2_1 - 8.7e-20 70.5 0.0 5.6e-10 39.0 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain TPKR_C2 PF16920.3 NM_001007156.2_1 - 4.2e-19 68.3 7.3 1.3e-18 66.7 7.3 1.9 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain ig PF00047.23 NM_001007156.2_1 - 8.6e-18 64.2 0.4 4.9e-15 55.3 0.3 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001007156.2_1 - 2.6e-17 63.1 1.5 1.2e-09 38.5 0.9 2.7 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.4 NM_001007156.2_1 - 5e-13 48.5 2.3 5e-13 48.5 2.3 1.9 2 0 0 2 2 2 1 Leucine rich repeat Ig_2 PF13895.4 NM_001007156.2_1 - 3.4e-12 46.4 1.1 6.4e-07 29.5 0.3 2.6 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 NM_001007156.2_1 - 2.8e-08 33.6 0.5 0.001 19.0 0.1 2.4 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain LRRNT PF01462.16 NM_001007156.2_1 - 1.8e-06 27.3 2.2 6.5e-06 25.5 2.2 2.1 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.4 NM_001007156.2_1 - 0.00013 21.8 0.9 0.00026 20.8 0.9 1.4 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_001007156.2_1 - 0.00044 20.4 2.2 0.003 17.8 2.2 2.5 1 1 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 NM_001007156.2_1 - 0.11 12.5 0.3 0.57 10.2 0.3 2.3 1 0 0 1 1 1 0 Leucine Rich repeat LRR_1 PF00560.31 NM_001007156.2_1 - 3.8 8.2 7.6 11 6.8 0.2 5.2 6 0 0 6 6 5 0 Leucine Rich Repeat RVT_1 PF00078.25 NM_001037232.3_2 - 0.0018 17.7 0.1 0.0031 16.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2_2 PF13465.4 NM_001037232.3_3 - 6.2e-73 238.1 65.8 1.9e-09 37.4 0.5 11.6 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001037232.3_3 - 7.2e-49 161.5 63.8 2e-05 24.7 0.3 10.9 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001037232.3_3 - 4.2e-25 86.1 61.4 0.014 16.0 0.7 10.8 10 0 0 10 10 10 9 C2H2-type zinc finger KRAB PF01352.25 NM_001037232.3_3 - 4.2e-22 77.4 0.7 7.6e-22 76.6 0.7 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001037232.3_3 - 7.5e-17 60.7 46.3 0.0044 16.8 0.2 9.8 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001037232.3_3 - 5.7e-10 39.1 43.2 0.094 12.9 0.4 9.6 9 0 0 9 9 9 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001037232.3_3 - 6.4e-06 26.1 51.3 0.0086 16.0 3.9 6.5 3 2 2 6 6 6 5 Zinc ribbon domain XPA_N PF01286.16 NM_001037232.3_3 - 0.01 15.7 40.9 8 6.5 2.1 9.3 9 0 0 9 9 9 0 XPA protein N-terminal zf-met PF12874.5 NM_001037232.3_3 - 0.014 15.7 0.7 0.014 15.7 0.7 8.9 9 0 0 9 9 9 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_001037232.3_3 - 0.26 11.0 29.2 4.5 7.0 0.2 7.6 7 0 0 7 7 7 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_001037232.3_3 - 0.84 10.3 39.5 2.9 8.6 2.3 5.3 1 1 3 5 5 5 0 zinc-ribbon family zf-BED PF02892.13 NM_001037232.3_3 - 2 8.4 44.9 1.2 9.1 0.0 8.5 3 2 5 8 8 8 0 BED zinc finger C1_4 PF07975.10 NM_001037232.3_3 - 3.1 8.0 40.3 0.1 12.8 0.2 6.5 4 1 5 9 9 9 0 TFIIH C1-like domain MARVEL PF01284.21 NM_004710.4_1 - 2.2e-20 73.0 13.4 3e-20 72.6 13.4 1.2 1 0 0 1 1 1 1 Membrane-associating domain CS PF04969.14 NM_032869.3_1 - 1.6e-16 60.9 1.6 8e-16 58.7 1.1 2.3 2 0 0 2 2 2 1 CS domain zf-H2C2_2 PF13465.4 NM_198088.2_3 - 6.4e-25 86.3 36.3 1.9e-08 34.2 0.7 6.4 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_198088.2_3 - 3e-20 71.4 40.4 2.9e-05 24.1 0.8 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_198088.2_3 - 2.3e-10 40.3 42.4 0.0033 18.0 0.6 6.2 6 0 0 6 6 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_198088.2_3 - 3.6e-06 27.0 16.8 0.021 15.0 0.2 4.5 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_198088.2_3 - 0.00032 21.2 12.4 0.049 14.3 0.6 3.6 1 1 2 3 3 3 3 zinc-ribbon family Zn-ribbon_8 PF09723.8 NM_198088.2_3 - 0.00058 19.8 22.5 0.044 13.8 3.0 4.0 1 1 4 5 5 5 5 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_198088.2_3 - 0.00059 19.6 37.1 0.095 12.6 0.3 6.1 6 0 0 6 6 5 4 C2H2-type zinc finger zf-met PF12874.5 NM_198088.2_3 - 0.00082 19.5 15.1 0.35 11.2 0.7 3.7 3 0 0 3 3 3 2 Zinc-finger of C2H2 type DZR PF12773.5 NM_198088.2_3 - 0.002 18.0 15.3 0.4 10.6 6.9 3.1 1 1 1 2 2 2 2 Double zinc ribbon KRAB PF01352.25 NM_198088.2_3 - 0.033 13.7 0.2 0.065 12.8 0.2 1.5 1 0 0 1 1 1 0 KRAB box DUF2709 PF10915.6 NM_198088.2_3 - 0.096 11.8 0.1 3.4 6.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2709) zf-Di19 PF05605.10 NM_198088.2_3 - 0.26 11.5 19.4 0.63 10.2 0.2 3.4 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.4 NM_198088.2_3 - 0.32 10.8 0.1 0.32 10.8 0.1 5.6 5 0 0 5 5 5 0 zinc-finger of a C2HC-type DUF3268 PF11672.6 NM_198088.2_3 - 2.7 8.2 11.1 3.6 7.8 1.6 2.8 1 1 1 3 3 3 0 zinc-finger-containing domain YhfH PF14149.4 NM_198088.2_3 - 5.9 6.8 15.8 27 4.7 0.0 5.1 5 0 0 5 5 5 0 YhfH-like protein HypA PF01155.17 NM_198088.2_3 - 6.9 6.6 14.3 0.6 10.0 0.9 3.1 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.10 NM_198088.2_3 - 8.2 6.4 19.3 6.2 6.8 4.1 3.6 2 1 1 3 3 3 0 zinc-ribbons UPAR_LY6_2 PF16975.3 NM_001317006.1_1 - 6.9e-54 180.4 17.8 1.1e-53 179.8 17.8 1.3 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 zf-met PF12874.5 NM_001282401.1_2 - 4.7e-13 48.9 20.0 1e-06 28.8 0.1 4.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-U1 PF06220.10 NM_001282401.1_2 - 1.3e-05 24.8 9.4 0.0065 16.1 0.2 4.1 4 0 0 4 4 4 2 U1 zinc finger zf-C2H2 PF00096.24 NM_001282401.1_2 - 0.0012 19.0 6.7 0.0014 18.8 0.7 3.6 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 NM_001282401.1_2 - 0.0084 16.3 17.4 0.014 15.6 0.1 4.3 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 NM_001282401.1_2 - 0.048 14.4 6.1 0.19 12.5 0.3 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger Tetraspannin PF00335.18 NM_004356.3_3 - 3.9e-46 157.4 13.5 4.8e-46 157.1 13.5 1.1 1 0 0 1 1 1 1 Tetraspanin family Ripply PF14998.4 NM_001317777.1_1 - 0.17 12.4 1.5 0.2 12.2 0.1 1.8 2 0 0 2 2 2 0 Transcription Regulator Ripply PF14998.4 NM_001317777.1_2 - 1.7e-15 57.2 0.1 4.3e-15 56.0 0.1 1.6 1 0 0 1 1 1 1 Transcription Regulator cEGF PF12662.5 NM_001317777.1_3 - 4.5 7.2 6.3 7.1 6.5 0.1 2.6 2 0 0 2 2 2 0 Complement Clr-like EGF-like EF-hand_1 PF00036.30 NM_079422.2_3 - 6e-11 40.9 0.9 0.0034 16.7 0.0 4.5 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_079422.2_3 - 7.2e-11 41.0 1.3 1.4e-05 24.5 0.1 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.4 NM_079422.2_3 - 2.2e-07 31.1 0.0 0.0063 16.8 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.4 NM_079422.2_3 - 0.00031 20.9 0.0 0.085 13.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 NM_079422.2_3 - 0.012 15.3 1.1 1.8 8.3 0.1 2.9 2 1 1 3 3 3 0 EF-hand domain pair Ig_2 PF13895.4 NM_001278428.3_3 - 1.7e-17 63.4 0.0 6.5e-11 42.3 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001278428.3_3 - 1.6e-09 37.7 0.0 3.4e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001278428.3_3 - 3.5e-09 37.0 0.2 0.00082 19.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Syntaphilin PF15290.4 NM_001099748.1_1 - 1e-138 462.1 0.8 1e-138 462.1 0.8 2.0 2 0 0 2 2 1 1 Golgi-localised syntaxin-1-binding clamp Fez1 PF06818.13 NM_001099748.1_1 - 0.00013 22.3 7.1 0.00025 21.4 7.1 1.4 1 0 0 1 1 1 1 Fez1 FAM76 PF16046.3 NM_001099748.1_1 - 0.00069 18.9 5.4 0.00069 18.9 5.4 2.0 2 1 1 3 3 3 2 FAM76 protein PKcGMP_CC PF16808.3 NM_001099748.1_1 - 0.011 15.5 6.2 0.011 15.5 6.2 3.4 4 1 0 4 4 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Exonuc_VII_L PF02601.13 NM_001099748.1_1 - 0.027 13.9 1.6 0.043 13.2 1.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FPP PF05911.9 NM_001099748.1_1 - 0.076 11.1 11.8 0.11 10.5 11.8 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil IncA PF04156.12 NM_001099748.1_1 - 0.13 11.9 8.4 0.26 10.9 8.4 1.4 1 0 0 1 1 1 0 IncA protein Atg14 PF10186.7 NM_001099748.1_1 - 0.15 11.0 6.5 0.32 9.9 6.5 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BST2 PF16716.3 NM_001099748.1_1 - 0.25 11.8 7.8 0.58 10.6 7.8 1.6 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 Sec8_exocyst PF04048.12 NM_001099748.1_1 - 0.27 11.0 7.4 0.78 9.5 0.3 2.3 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Sec2p PF06428.9 NM_001099748.1_1 - 0.31 10.9 12.9 0.11 12.3 2.5 2.6 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p HR1 PF02185.14 NM_001099748.1_1 - 0.43 10.6 9.8 0.67 10.0 1.4 2.5 2 0 0 2 2 2 0 Hr1 repeat DUF342 PF03961.11 NM_001099748.1_1 - 0.49 8.8 4.3 0.69 8.3 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Spc42p PF11544.6 NM_001099748.1_1 - 1.4 8.8 7.1 0.41 10.5 1.1 2.5 2 0 0 2 2 2 0 Spindle pole body component Spc42p DUF745 PF05335.11 NM_001099748.1_1 - 1.5 8.4 6.3 2.3 7.8 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) CC2-LZ PF16516.3 NM_001099748.1_1 - 2.5 8.3 11.6 2.5 8.4 3.0 2.3 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF16 PF01519.14 NM_001099748.1_1 - 2.7 8.4 9.1 35 4.8 9.1 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 HMMR_N PF15905.3 NM_001099748.1_1 - 3.1 7.1 17.2 0.012 14.9 8.2 1.5 2 0 0 2 2 1 0 Hyaluronan mediated motility receptor N-terminal CALCOCO1 PF07888.9 NM_001099748.1_1 - 3.7 5.9 18.7 0.042 12.3 11.1 1.5 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TPR_MLP1_2 PF07926.10 NM_001099748.1_1 - 4.8 7.1 13.5 1.3 9.0 6.5 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 NM_001099748.1_1 - 5.3 5.7 14.5 2 7.1 11.1 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein GrpE PF01025.17 NM_001099748.1_1 - 5.8 6.4 9.1 9.8 5.7 9.1 1.2 1 0 0 1 1 1 0 GrpE LRR_8 PF13855.4 NM_001128922.1_1 - 1.3e-67 223.3 59.8 3.1e-16 58.7 2.6 9.7 8 1 1 9 9 9 9 Leucine rich repeat LRR_4 PF12799.5 NM_001128922.1_1 - 2.1e-42 142.1 54.3 9.9e-07 28.8 1.2 12.2 9 2 1 11 11 11 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001128922.1_1 - 5.7e-16 56.3 56.4 1.2 9.7 1.2 20.3 19 3 2 21 21 21 3 Leucine Rich Repeat LRR_9 PF14580.4 NM_001128922.1_1 - 2.7e-07 30.1 10.6 0.023 14.1 0.2 5.4 3 2 2 5 5 5 3 Leucine-rich repeat LRR_5 PF13306.4 NM_001128922.1_1 - 6.4e-07 29.2 0.0 0.003 17.4 0.0 3.8 4 0 0 4 4 4 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 NM_001128922.1_1 - 2.3e-06 26.9 0.5 9.6e-06 25.0 0.5 2.2 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 NM_001128922.1_1 - 0.75 9.9 68.8 9.3 6.5 0.1 17.1 20 0 0 20 20 20 0 Leucine Rich repeat VWA PF00092.26 NM_001135058.1_3 - 6e-78 261.0 0.2 4e-40 137.8 0.1 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 NM_001135058.1_3 - 1.5e-24 86.6 0.0 3.4e-11 43.6 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.17 NM_001135058.1_3 - 2.8e-21 75.3 0.0 5.9e-21 74.3 0.0 1.5 1 0 0 1 1 1 1 LCCL domain VWA_3 PF13768.4 NM_001135058.1_3 - 0.00056 19.7 0.0 1 9.1 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain Tmemb_14 PF03647.11 NM_030969.4_3 - 2.3e-22 79.4 11.7 3e-22 79.0 11.7 1.2 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.7 NM_030969.4_3 - 0.0026 17.9 3.0 0.0036 17.5 3.0 1.2 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 AIG1 PF04548.14 NM_001195138.1_1 - 3.1e-25 88.6 0.0 4.1e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.21 NM_001195138.1_1 - 7.6e-05 22.6 0.0 0.00014 21.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF4460 PF14687.4 NM_001195138.1_1 - 0.0064 16.4 0.5 0.011 15.7 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) Dynamin_N PF00350.21 NM_001195138.1_1 - 0.015 15.3 0.1 0.21 11.5 0.1 2.3 2 0 0 2 2 2 0 Dynamin family BORA_N PF15280.4 NM_024808.3_2 - 7.7e-71 238.2 1.4 2.2e-70 236.8 1.4 1.8 1 0 0 1 1 1 1 Protein aurora borealis N-terminus Septin PF00735.16 NM_001321034.1_3 - 1.6e-126 421.1 0.1 2.1e-126 420.7 0.1 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 NM_001321034.1_3 - 5.1e-07 29.6 0.0 1.1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_001321034.1_3 - 6.1e-05 22.8 0.2 0.004 16.9 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_001321034.1_3 - 6.6e-05 22.4 0.1 0.015 14.7 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.14 NM_001321034.1_3 - 0.0012 18.1 0.0 0.0024 17.1 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Ras PF00071.20 NM_001321034.1_3 - 0.0037 16.7 0.0 0.0063 16.0 0.0 1.3 1 0 0 1 1 1 1 Ras family Dynamin_N PF00350.21 NM_001321034.1_3 - 0.0071 16.3 0.1 0.33 10.9 0.0 2.4 1 1 1 2 2 2 1 Dynamin family Roc PF08477.11 NM_001321034.1_3 - 0.029 14.5 0.0 0.052 13.7 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_001321034.1_3 - 0.03 14.6 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 NM_001321034.1_3 - 0.041 14.0 0.1 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.4 NM_001321034.1_3 - 0.048 13.3 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 NM_001321034.1_3 - 0.061 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Sugar_tr PF00083.22 NM_021977.3_3 - 2.6e-25 89.1 25.6 2.5e-24 85.8 19.7 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 NM_021977.3_3 - 4.9e-25 88.1 26.5 4.9e-25 88.1 26.5 2.9 2 1 1 3 3 3 2 Major Facilitator Superfamily PA26 PF04636.11 NM_001271594.1_2 - 2.2e-156 521.1 4.2 9.5e-134 446.5 1.4 2.1 1 1 1 2 2 2 2 PA26 p53-induced protein (sestrin) Transglut_N PF00868.18 NM_001254734.1_2 - 1.1e-31 109.5 0.0 1.8e-31 108.8 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase family Transglut_C PF00927.20 NM_001254734.1_2 - 3.2e-22 78.5 0.0 5.5e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.17 NM_001254734.1_2 - 2.1e-16 60.2 0.2 4e-16 59.3 0.2 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_C PF00927.20 NM_001254734.1_3 - 2.7e-06 27.3 0.0 4.1e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain CAP PF00188.24 NM_001261822.1_2 - 2.1e-24 86.6 2.8 3.9e-24 85.8 2.8 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Crisp PF08562.8 NM_001261822.1_2 - 7.6e-19 67.9 20.6 2.1e-18 66.5 20.6 1.8 1 0 0 1 1 1 1 Crisp Pyr_redox_2 PF07992.12 NM_000637.3_3 - 3.8e-61 206.8 0.1 5.2e-61 206.3 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 NM_000637.3_3 - 1.3e-35 121.8 1.0 1.3e-35 121.8 1.0 1.7 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 NM_000637.3_3 - 1.1e-20 73.8 5.3 1.9e-19 69.9 0.4 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 NM_000637.3_3 - 3.5e-16 59.2 0.1 7.9e-16 58.0 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 NM_000637.3_3 - 4.9e-06 26.0 0.1 1.1e-05 24.9 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 NM_000637.3_3 - 9e-06 24.9 4.4 0.0041 16.1 2.5 2.5 3 0 0 3 3 3 2 FAD binding domain AlaDh_PNT_C PF01262.19 NM_000637.3_3 - 0.00023 20.4 2.2 0.11 11.7 0.5 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.20 NM_000637.3_3 - 0.005 15.8 3.7 0.02 13.9 1.3 2.5 3 0 0 3 3 3 1 Glucose inhibited division protein A NAD_binding_8 PF13450.4 NM_000637.3_3 - 0.025 14.7 0.5 0.025 14.7 0.5 1.8 2 0 0 2 2 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.22 NM_000637.3_3 - 0.033 13.7 3.3 0.16 11.5 3.2 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.12 NM_000637.3_3 - 0.074 11.6 2.6 0.16 10.5 0.5 2.2 3 0 0 3 3 3 0 HI0933-like protein FAD_binding_3 PF01494.17 NM_000637.3_3 - 0.58 9.2 2.7 1.9 7.5 0.4 2.0 2 0 0 2 2 2 0 FAD binding domain KRAB PF01352.25 NM_001305039.1_1 - 1.4e-25 88.6 0.2 2.6e-25 87.7 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 NM_001305039.1_2 - 3.1e-111 359.1 140.9 5.7e-09 35.9 2.2 18.2 18 0 0 18 18 18 17 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001305039.1_2 - 1e-79 258.7 169.2 7.2e-06 26.1 2.0 18.2 18 0 0 18 18 18 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001305039.1_2 - 2.9e-31 105.3 159.6 0.0068 17.0 1.5 18.7 18 0 0 18 18 18 16 C2H2-type zinc finger RVT_1 PF00078.25 NM_001305039.1_2 - 0.00075 18.9 0.1 0.0014 18.0 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) C1_4 PF07975.10 NM_001305039.1_2 - 0.0027 17.8 98.6 0.014 15.5 5.3 12.0 3 2 9 13 13 13 5 TFIIH C1-like domain zf-C2H2_6 PF13912.4 NM_001305039.1_2 - 0.0069 16.2 135.4 0.24 11.3 1.1 17.1 16 1 0 16 16 16 9 C2H2-type zinc finger BolA PF01722.16 NM_001305039.1_2 - 0.099 12.8 20.1 1 9.6 0.1 6.5 4 2 2 6 6 6 0 BolA-like protein zf-H2C2_2 PF13465.4 NM_001278678.1_1 - 3.1e-97 314.9 135.0 4.7e-09 36.1 1.6 18.5 18 0 0 18 18 18 16 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001278678.1_1 - 2.5e-66 216.5 94.9 2.7e-05 24.2 0.5 16.7 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001278678.1_1 - 8.6e-29 97.6 95.2 0.012 16.2 0.7 15.8 15 0 0 15 15 14 14 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001278678.1_1 - 4.8e-21 74.4 53.3 0.06 13.6 0.2 15.1 15 0 0 15 15 14 9 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001278678.1_1 - 2.3e-17 62.6 70.2 0.54 10.2 0.1 15.7 16 0 0 16 16 16 14 XPA protein N-terminal zf-C2H2_6 PF13912.4 NM_001278678.1_1 - 8e-14 51.1 93.6 0.019 14.7 0.3 16.4 15 3 0 15 15 15 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001278678.1_1 - 1.4e-13 50.6 80.8 0.074 13.1 4.4 11.1 4 2 10 14 14 14 13 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001278678.1_1 - 1.1e-11 44.1 43.8 2.6 7.8 0.0 15.0 16 0 0 16 16 16 6 zinc-finger C2H2-type zf-trcl PF13451.4 NM_001278678.1_1 - 2.7e-11 43.0 67.0 0.35 10.7 0.1 13.0 11 3 1 12 12 12 7 Probable zinc-ribbon domain SprT-like PF10263.7 NM_001278678.1_1 - 5.5e-07 29.4 78.4 0.035 13.8 5.1 7.8 1 1 5 7 7 7 6 SprT-like family ADK_lid PF05191.12 NM_001278678.1_1 - 0.0077 16.1 48.0 1.6 8.7 0.7 8.8 3 2 7 10 10 10 6 Adenylate kinase, active site lid DZR PF12773.5 NM_001278678.1_1 - 0.0082 16.0 60.0 1.6e+04 -41.2 60.0 8.0 1 1 0 1 1 0 0 Double zinc ribbon BolA PF01722.16 NM_001278678.1_1 - 4.3 7.6 14.8 43 4.3 0.1 6.4 4 2 0 6 6 6 0 BolA-like protein zinc_ribbon_15 PF17032.3 NM_001278678.1_1 - 9.9 6.9 74.4 4.1 8.1 2.8 8.0 1 1 5 9 9 9 0 zinc-ribbon family Antimicrobial_2 PF08023.10 NM_001278678.1_2 - 0.0024 18.2 0.4 48 4.5 0.0 6.1 7 1 0 7 7 7 2 Frog antimicrobial peptide CH PF00307.29 NM_024734.3_3 - 2.7e-42 143.3 0.3 1.2e-19 70.4 0.3 2.8 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_024734.3_3 - 0.00011 21.9 0.0 0.031 14.0 0.0 2.5 2 0 0 2 2 2 2 CAMSAP CH domain Qua1 PF16274.3 NM_001271878.1_3 - 8.2e-33 112.1 2.6 1.5e-32 111.2 2.6 1.5 1 0 0 1 1 1 1 Qua1 domain Sam68-YY PF16568.3 NM_001271878.1_3 - 8.8e-15 55.0 36.5 1.4e-14 54.4 36.5 1.3 1 0 0 1 1 1 1 Tyrosine-rich domain of Sam68 E1-N PF14463.4 NM_153706.3_2 - 0.092 12.4 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 E1 N-terminal domain SET PF00856.26 NM_153706.3_3 - 0.0009 19.5 0.3 0.0015 18.8 0.3 1.3 1 1 0 1 1 1 1 SET domain MYT1 PF08474.9 NM_015025.3_1 - 9.2e-119 395.6 7.8 9.2e-119 395.6 7.8 2.8 2 1 1 3 3 3 1 Myelin transcription factor 1 zf-C2HC PF01530.16 NM_015025.3_1 - 7.7e-84 275.3 88.3 2.5e-15 56.2 7.2 7.6 7 0 0 7 7 7 6 Zinc finger, C2HC type DUF1664 PF07889.10 NM_015025.3_1 - 0.37 10.6 4.0 0.95 9.3 4.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DivIC PF04977.13 NM_015025.3_1 - 0.74 9.5 12.5 1.2 8.8 2.8 2.6 1 1 1 2 2 2 0 Septum formation initiator bZIP_1 PF00170.19 NM_015025.3_1 - 9.6 6.3 12.0 4.1 7.4 3.6 2.9 1 1 1 2 2 2 0 bZIP transcription factor SET PF00856.26 NM_004456.4_2 - 7.6e-18 65.3 0.5 7.6e-18 65.3 0.5 3.0 2 2 0 2 2 2 1 SET domain EZH2_WD-Binding PF11616.6 NM_004456.4_2 - 1.4e-16 60.2 2.5 3.3e-16 58.9 2.5 1.7 1 0 0 1 1 1 1 WD repeat binding protein EZH2 ANF_receptor PF01094.26 NM_000845.2_3 - 9.6e-105 350.4 0.0 1.3e-104 350.0 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 NM_000845.2_3 - 2.3e-59 200.9 16.4 3.7e-59 200.2 16.4 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 NM_000845.2_3 - 2.5e-14 52.8 11.6 6.4e-14 51.5 11.6 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 NM_000845.2_3 - 1.1e-06 28.5 0.0 2.4e-06 27.4 0.0 1.5 2 0 0 2 2 2 1 Periplasmic binding protein NAP PF00956.16 NM_001287737.1_2 - 2.5e-31 108.7 28.6 1.2e-27 96.7 13.1 3.3 1 1 2 3 3 3 2 Nucleosome assembly protein (NAP) Nore1-SARAH PF16517.3 NM_001287737.1_2 - 0.026 14.4 1.8 0.11 12.3 1.8 2.1 1 0 0 1 1 1 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain ZapB PF06005.10 NM_001287737.1_2 - 0.081 13.2 3.6 0.21 11.9 3.6 1.6 1 0 0 1 1 1 0 Cell division protein ZapB DUF1492 PF07374.9 NM_001287737.1_2 - 0.17 11.9 1.2 0.33 11.0 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) DUF2441 PF10386.7 NM_000651.4_1 - 4.1 7.3 7.1 53 3.7 0.0 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2441) Sushi PF00084.18 NM_000651.4_3 - 0 1040.1 215.1 2.1e-12 47.3 1.3 37.6 37 0 0 37 37 37 37 Sushi repeat (SCR repeat) Invas_SpaK PF03519.12 NM_000651.4_3 - 4e-08 33.1 0.1 14 5.8 0.0 5.5 5 0 0 5 5 5 4 Invasion protein B family DUF1737 PF08410.8 NM_000651.4_3 - 0.026 14.2 0.0 12 5.7 0.0 4.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1737) zf-UBP PF02148.17 NM_000651.4_3 - 0.065 13.4 0.9 3.6e+02 1.4 0.0 5.9 8 0 0 8 8 8 0 Zn-finger in ubiquitin-hydrolases and other protein RNA_pol_Rpb5_C PF01191.17 NM_000651.4_3 - 0.13 11.9 0.0 2.4e+02 1.5 0.0 4.0 4 0 0 4 4 4 0 RNA polymerase Rpb5, C-terminal domain UPF0054 PF02130.15 NM_058181.2_3 - 1.9e-29 101.9 0.0 2.5e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 PUMA PF15826.3 NM_014417.4_3 - 3.7e-96 320.6 17.9 7.2e-96 319.7 17.9 1.5 1 0 0 1 1 1 1 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis zf-H2C2_2 PF13465.4 NM_001321524.1_1 - 8.3e-192 613.8 261.4 3.2e-09 36.7 1.1 32.3 33 0 0 33 33 32 28 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001321524.1_1 - 3e-132 424.1 272.8 1.3e-06 28.4 1.5 30.9 31 0 0 31 31 30 28 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001321524.1_1 - 2e-60 196.0 253.0 0.0053 17.3 1.3 31.1 31 0 0 31 31 30 27 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001321524.1_1 - 6.1e-31 105.7 208.5 0.0049 16.7 0.5 29.5 29 1 0 29 29 29 20 C2H2-type zinc finger KRAB PF01352.25 NM_001321524.1_1 - 3e-26 90.7 0.2 5.4e-26 89.9 0.2 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001321524.1_1 - 4.7e-21 74.5 162.7 0.019 15.0 2.0 20.8 11 7 14 25 25 25 20 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001321524.1_1 - 9.2e-19 66.8 136.4 0.087 12.5 1.2 27.0 28 0 0 28 28 28 13 zinc-finger C2H2-type C1_1 PF00130.20 NM_001321524.1_1 - 2.9e-09 36.6 129.2 0.12 12.2 3.1 19.0 3 2 20 24 24 24 15 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_5 PF13909.4 NM_001321524.1_1 - 9.4e-08 31.5 22.9 0.0013 18.3 0.2 25.6 29 2 0 29 29 23 9 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 NM_001321524.1_1 - 0.00099 19.2 149.9 0.0076 16.4 0.2 25.8 28 0 0 28 28 27 8 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001321524.1_1 - 0.0022 18.6 141.1 0.71 10.5 1.8 15.0 5 2 8 16 16 15 8 zinc-ribbon family BolA PF01722.16 NM_001321524.1_1 - 0.0038 17.4 52.9 2.5 8.3 0.3 13.3 9 3 2 12 12 12 4 BolA-like protein MBD PF01429.17 NM_001321524.1_1 - 0.0062 16.1 11.7 2.2 7.9 0.1 6.3 5 2 0 5 5 5 1 Methyl-CpG binding domain zf-met PF12874.5 NM_001321524.1_1 - 0.027 14.7 0.6 0.027 14.7 0.6 27.9 29 1 1 30 30 29 0 Zinc-finger of C2H2 type DZR PF12773.5 NM_001321524.1_1 - 0.086 12.7 138.3 0.14 12.1 2.5 15.1 3 3 5 8 8 7 0 Double zinc ribbon HypA PF01155.17 NM_001321524.1_1 - 1.4 8.8 120.3 3.9 7.4 0.8 15.1 2 1 11 14 14 13 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Bac_DnaA_C PF08299.9 NM_001321524.1_2 - 0.00021 21.1 0.2 4.6 7.2 0.0 5.2 5 0 0 5 5 5 2 Bacterial dnaA protein helix-turn-helix Tox-REase-7 PF15649.4 NM_001321524.1_2 - 0.084 13.1 15.0 25 5.1 0.0 5.8 5 1 1 6 6 6 0 Restriction endonuclease fold toxin 7 zf-C2H2 PF00096.24 NM_001321524.1_3 - 1.8e-08 34.2 24.1 0.00014 22.0 0.5 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001321524.1_3 - 1.8e-07 31.1 19.8 7.4e-06 26.0 0.5 3.6 2 1 1 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001321524.1_3 - 0.02 15.5 0.3 0.02 15.5 0.3 4.8 4 0 0 4 4 4 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001321524.1_3 - 2.4 8.2 11.0 2.1 8.4 0.1 3.2 3 0 0 3 3 3 0 Zinc ribbon domain zf-LYAR PF08790.9 NM_001321524.1_3 - 3.3 7.6 8.4 6.5 6.6 0.2 3.0 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger P53_tetramer PF07710.9 NM_001126116.1_1 - 1.8e-10 39.8 0.9 3.1e-10 39.1 0.9 1.4 1 0 0 1 1 1 1 P53 tetramerisation motif P53 PF00870.16 NM_001126116.1_3 - 7.5e-99 329.1 0.3 1.1e-98 328.6 0.3 1.1 1 0 0 1 1 1 1 P53 DNA-binding domain Pox_vIL-18BP PF05566.10 NM_005699.3_2 - 0.026 14.6 0.0 0.043 13.9 0.0 1.3 1 0 0 1 1 1 0 Orthopoxvirus interleukin 18 binding protein DNA_pol_A PF00476.18 NM_002693.2_1 - 7e-60 202.9 0.0 1.1e-59 202.2 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A DUF2722 PF10846.6 NM_002693.2_1 - 0.0087 14.9 0.5 0.012 14.4 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DNA_pol_A_exo1 PF01612.18 NM_002693.2_1 - 0.011 15.4 0.0 0.057 13.0 0.0 1.9 1 1 0 1 1 1 0 3'-5' exonuclease Imm58 PF15581.4 NM_002693.2_1 - 0.063 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 58 Spt20 PF12090.6 NM_002693.2_1 - 7.4 6.0 12.9 14 5.1 12.9 1.3 1 0 0 1 1 1 0 Spt20 family IMUP PF15761.3 NM_002693.2_2 - 5.3 7.6 15.1 0.3 11.7 8.9 2.1 2 0 0 2 2 2 0 Immortalisation up-regulated protein Lectin_C PF00059.19 NM_002543.3_1 - 2.2e-15 57.2 0.0 5.7e-15 55.9 0.0 1.7 1 0 0 1 1 1 1 Lectin C-type domain Ly49 PF08391.8 NM_002543.3_1 - 2.1e-07 31.1 1.9 4.6e-07 30.1 1.9 1.6 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region UL45 PF05473.10 NM_002543.3_1 - 2.4e-06 27.2 0.3 0.00026 20.5 0.1 2.3 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like HemX PF04375.12 NM_002543.3_1 - 0.00013 21.3 6.3 0.00019 20.7 6.3 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase IncA PF04156.12 NM_002543.3_1 - 0.0008 19.1 4.1 0.0014 18.3 4.1 1.3 1 0 0 1 1 1 1 IncA protein FAM176 PF14851.4 NM_002543.3_1 - 0.0019 17.8 1.5 0.0032 17.0 1.5 1.3 1 0 0 1 1 1 1 FAM176 family DUF1664 PF07889.10 NM_002543.3_1 - 0.035 14.0 7.7 0.067 13.0 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4446 PF14584.4 NM_002543.3_1 - 0.1 12.4 1.8 0.18 11.7 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) SMP_2 PF10144.7 NM_002543.3_1 - 0.35 10.4 3.9 0.6 9.6 3.9 1.4 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin DUF2570 PF10828.6 NM_002543.3_1 - 0.42 10.4 7.6 0.89 9.3 7.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) OSTbeta PF15048.4 NM_002543.3_1 - 0.53 10.3 3.3 1.1 9.3 3.3 1.4 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein DUF1690 PF07956.9 NM_002543.3_1 - 0.66 10.3 11.2 1.2 9.4 11.2 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Bap31 PF05529.10 NM_002543.3_1 - 2.7 7.4 8.2 4.5 6.7 8.2 1.3 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like zf-RING_6 PF14835.4 NM_001282545.1_2 - 4e-19 68.1 2.4 1e-18 66.8 2.4 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein BRCT_2 PF16589.3 NM_001282545.1_2 - 8.7e-09 35.5 0.1 8.1e-06 26.0 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.24 NM_001282545.1_2 - 9.5e-08 32.2 0.0 0.0019 18.5 0.0 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-RING_5 PF14634.4 NM_001282545.1_2 - 0.0094 15.8 3.7 0.028 14.3 3.7 1.8 1 0 0 1 1 1 1 zinc-RING finger domain Ig_2 PF13895.4 NM_001002273.2_2 - 1.8e-25 89.0 2.9 1.2e-11 44.7 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001002273.2_2 - 7.7e-18 64.8 1.2 2.5e-09 37.5 0.4 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001002273.2_2 - 2.9e-11 43.2 3.8 0.00012 22.0 0.1 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.3 NM_001002273.2_2 - 2.5e-07 30.8 1.3 0.00028 21.0 0.0 2.5 3 0 0 3 3 2 2 T-cell surface glycoprotein CD3 delta chain I-set PF07679.14 NM_001002273.2_2 - 8.4e-07 28.8 0.4 0.019 14.9 0.4 3.0 2 1 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.15 NM_001002273.2_2 - 1.1e-05 25.4 6.2 1.5 8.9 0.1 4.1 2 2 2 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001002273.2_2 - 0.0024 17.8 0.3 1.5 8.8 0.0 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain DUF3827 PF12877.5 NM_001002273.2_2 - 0.016 13.5 0.4 0.022 13.0 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) TMEM154 PF15102.4 NM_001002273.2_2 - 0.032 14.0 0.0 0.055 13.2 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family ECSCR PF15820.3 NM_001002273.2_2 - 0.099 12.3 0.6 0.18 11.5 0.2 1.5 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Adeno_E3_CR2 PF02439.13 NM_001002273.2_2 - 0.32 10.7 5.8 0.92 9.2 5.8 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DDE_1 PF03184.17 NM_001194938.1_1 - 5.3e-12 45.5 0.0 1.2e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 NM_001194938.1_1 - 6.2e-09 35.6 1.3 8.3e-09 35.2 0.1 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain zf-C2H2_4 PF13894.4 NM_001194938.1_1 - 1.8e-06 28.1 67.5 0.16 12.7 0.5 10.2 9 0 0 9 9 9 5 C2H2-type zinc finger HTH_28 PF13518.4 NM_001194938.1_1 - 0.0039 17.2 0.2 0.0076 16.2 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain zf-RRN7 PF11781.6 NM_001194938.1_1 - 0.024 14.2 5.7 1.9 8.1 0.1 3.2 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DDE_3 PF13358.4 NM_001194938.1_1 - 0.12 11.9 0.1 0.34 10.5 0.0 1.7 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_23 PF13384.4 NM_001194938.1_1 - 0.15 11.8 0.2 0.48 10.1 0.1 1.9 2 0 0 2 2 2 0 Homeodomain-like domain Snf7 PF03357.19 NM_024591.4_1 - 3.7e-40 137.2 18.9 4.7e-40 136.9 18.9 1.1 1 0 0 1 1 1 1 Snf7 DUF1043 PF06295.10 NM_024591.4_1 - 0.0042 17.0 4.0 0.0042 17.0 4.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1043) Het-C PF07217.9 NM_024591.4_1 - 1.5 7.1 4.8 2 6.7 4.8 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Peptidase_S46 PF10459.7 NM_024591.4_1 - 1.7 7.1 7.6 2.1 6.7 7.6 1.0 1 0 0 1 1 1 0 Peptidase S46 Cytochrom_B558a PF05038.11 NM_000101.3_3 - 7.8e-103 341.7 1.1 7.8e-103 341.7 1.1 1.4 2 0 0 2 2 2 1 Cytochrome Cytochrome b558 alpha-subunit Cg6151-P PF10233.7 NM_000101.3_3 - 5.8e-05 23.2 1.0 0.039 14.1 0.7 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein CG6151-P DUF308 PF03729.11 NM_000101.3_3 - 0.23 11.7 12.5 0.31 11.3 0.7 2.8 2 1 1 3 3 3 0 Short repeat of unknown function (DUF308) zf-C2H2 PF00096.24 NM_020807.2_3 - 1.1e-52 173.5 132.5 7e-06 26.1 0.9 17.2 17 0 0 17 17 17 14 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_020807.2_3 - 4.7e-47 156.3 130.6 2.5e-11 43.3 1.2 16.9 16 0 0 16 16 16 11 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_020807.2_3 - 3.7e-33 111.2 129.9 0.0036 17.9 0.8 17.2 18 0 0 18 18 18 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_020807.2_3 - 2.7e-20 72.0 74.9 0.0041 17.3 0.1 15.2 16 0 0 16 16 16 11 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_020807.2_3 - 6.4e-12 45.3 85.3 0.018 15.3 0.2 14.5 14 0 0 14 14 14 8 Zinc-finger of C2H2 type zf-Di19 PF05605.10 NM_020807.2_3 - 2.7e-05 24.2 90.2 0.022 14.9 5.5 10.3 6 3 3 10 10 10 7 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 NM_020807.2_3 - 0.0041 16.9 0.3 0.0041 16.9 0.3 15.4 16 0 0 16 16 16 6 C2H2-type zinc finger BolA PF01722.16 NM_020807.2_3 - 1.3 9.3 28.3 18 5.6 0.1 7.9 5 3 2 9 9 9 0 BolA-like protein zf-C2H2_8 PF15909.3 NM_020807.2_3 - 9.7 6.4 60.9 3.4 7.9 5.0 7.3 2 2 4 6 6 6 0 C2H2-type zinc ribbon zf-C2H2_9 PF16293.3 NM_020807.2_3 - 9.9 6.0 30.6 7.6 6.3 0.1 8.6 8 0 0 8 8 8 0 C2H2 type zinc-finger (1 copy) Furin-like_2 PF15913.3 NM_001040007.2_2 - 6.6e-46 154.8 23.0 1.2e-45 153.9 23.0 1.4 1 0 0 1 1 1 1 Furin-like repeat, cysteine-rich MORN PF02493.18 NM_198469.3_3 - 2.5e-13 49.0 8.9 4.3e-06 26.2 0.4 5.1 4 1 0 4 4 4 3 MORN repeat WD40 PF00400.30 NM_001017977.2_3 - 6.3e-17 61.5 9.0 0.013 16.2 0.1 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001017977.2_3 - 1.8e-08 34.4 0.0 0.029 14.5 0.0 4.3 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_001017977.2_3 - 0.15 11.2 0.1 0.25 10.5 0.1 1.3 1 0 0 1 1 1 0 WD40-like domain VWD PF00094.23 NM_000552.4_1 - 2.7e-134 443.6 16.0 6.3e-40 136.9 0.1 4.6 4 0 0 4 4 4 4 von Willebrand factor type D domain VWA PF00092.26 NM_000552.4_1 - 4.4e-82 274.4 0.0 1.3e-32 113.3 0.0 3.2 3 0 0 3 3 3 3 von Willebrand factor type A domain C8 PF08742.9 NM_000552.4_1 - 2.1e-54 181.7 57.8 1.4e-17 63.8 6.9 9.5 9 1 0 9 9 9 4 C8 domain VWA_N2 PF16164.3 NM_000552.4_1 - 1.5e-40 137.1 3.4 1.5e-40 137.1 3.4 8.5 10 0 0 10 10 10 1 VWA N-terminal TIL PF01826.15 NM_000552.4_1 - 7.6e-30 102.8 108.0 1.7e-12 47.3 15.0 20.6 18 2 3 21 21 21 5 Trypsin Inhibitor like cysteine rich domain VWA_2 PF13519.4 NM_000552.4_1 - 8.5e-27 93.8 0.0 2e-08 34.7 0.0 3.4 3 0 0 3 3 3 3 von Willebrand factor type A domain VWC PF00093.16 NM_000552.4_1 - 1.4e-18 66.8 89.6 1.4e-08 34.7 13.2 22.4 15 5 6 21 21 21 6 von Willebrand factor type C domain Pacifastin_I PF05375.11 NM_000552.4_1 - 0.00047 19.7 24.6 0.00098 18.7 8.1 12.2 12 1 0 12 12 12 2 Pacifastin inhibitor (LCMII) MCR_beta_N PF02783.13 NM_000552.4_1 - 0.023 14.2 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain Hexokinase_2 PF03727.14 NM_025130.3_2 - 3.7e-173 573.1 0.7 4.2e-89 298.0 0.1 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.19 NM_025130.3_2 - 1.4e-144 478.7 0.1 1.3e-73 247.1 0.0 2.2 2 0 0 2 2 2 2 Hexokinase Stathmin PF00836.17 NM_203401.1_2 - 2.7e-59 198.9 28.5 3.3e-59 198.6 28.5 1.1 1 0 0 1 1 1 1 Stathmin family Ribonuc_2-5A PF06479.10 NM_203401.1_2 - 0.61 10.1 7.1 1.1 9.3 7.1 1.3 1 0 0 1 1 1 0 Ribonuclease 2-5A Exonuc_VII_L PF02601.13 NM_203401.1_2 - 1.8 7.9 9.0 2.5 7.4 9.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Homeobox PF00046.27 NM_001112704.1_3 - 9.1e-22 76.5 7.3 1.5e-21 75.8 7.3 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_001112704.1_3 - 0.0041 16.8 0.7 0.0088 15.8 0.7 1.5 1 0 0 1 1 1 1 Homeobox KN domain HTH_28 PF13518.4 NM_001112704.1_3 - 0.066 13.2 0.1 0.19 11.8 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Homez PF11569.6 NM_001112704.1_3 - 0.079 12.3 0.2 0.17 11.3 0.2 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez MHC_I PF00129.16 NM_001289161.1_1 - 3.9e-14 52.5 1.0 1.3e-11 44.3 0.0 2.3 1 1 1 2 2 2 2 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_001289161.1_1 - 2.3e-10 40.6 0.1 5e-10 39.6 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 NM_001289161.1_1 - 0.00038 20.9 0.5 0.0008 19.8 0.5 1.5 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 NM_001289161.1_1 - 0.036 14.0 1.3 0.073 13.0 0.7 1.8 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 NM_001289161.1_1 - 0.073 13.3 0.4 0.16 12.2 0.4 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Meleagrin PF08189.9 NM_001289161.1_2 - 9.4 5.9 9.4 0.11 12.0 1.2 2.1 2 0 0 2 2 2 0 Meleagrin/Cygnin family VKG_Carbox PF05090.12 NM_000821.6_2 - 1.1e-167 558.2 8.9 1.5e-167 557.8 8.9 1.2 1 0 0 1 1 1 1 Vitamin K-dependent gamma-carboxylase Cupin_2 PF07883.9 NM_000821.6_2 - 0.059 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Cupin domain VWA_3 PF13768.4 NM_001320373.1_2 - 7.3e-37 126.5 0.0 1.2e-36 125.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain HLH PF00010.24 NM_001136139.2_1 - 6.6e-10 38.7 0.7 1.1e-09 37.9 0.7 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 NM_001136139.2_1 - 3.7 5.6 5.8 5.1 5.1 5.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DEAD PF00270.27 NM_001321732.1_2 - 1.2e-43 148.8 0.0 4.1e-43 147.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001321732.1_2 - 1.7e-31 108.7 0.0 7e-30 103.5 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain zf-CCHC PF00098.21 NM_001321732.1_2 - 0.0017 18.2 1.5 0.0038 17.1 1.5 1.6 1 0 0 1 1 1 1 Zinc knuckle ResIII PF04851.13 NM_001321732.1_2 - 0.054 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 NM_001321732.1_2 - 0.15 11.1 0.0 0.33 10.0 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase SecA_DEAD PF07517.12 NM_001321732.1_2 - 0.17 11.0 0.0 0.42 9.7 0.0 1.7 2 0 0 2 2 2 0 SecA DEAD-like domain UTP25 PF06862.10 NM_001321732.1_2 - 0.17 10.4 0.0 0.43 9.2 0.0 1.5 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 zf-CCHC_4 PF14392.4 NM_001321732.1_2 - 0.2 11.3 1.3 0.41 10.3 1.3 1.6 1 0 0 1 1 1 0 Zinc knuckle WD40 PF00400.30 NM_001136198.1_2 - 1.5e-25 88.8 5.4 1.2e-05 25.8 0.0 7.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001136198.1_2 - 1.5e-13 50.7 5.3 1.9e-05 24.8 0.2 4.3 2 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_001136198.1_2 - 0.00015 21.6 0.1 0.58 9.9 0.1 3.0 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 NM_001136198.1_2 - 0.083 11.4 0.2 0.16 10.4 0.2 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 NM_001136198.1_2 - 0.087 11.6 0.0 0.33 9.7 0.0 1.8 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Sulfate_transp PF00916.18 NM_001040454.1_3 - 2.7e-110 368.6 20.3 3.9e-110 368.1 20.3 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 NM_001040454.1_3 - 1.4e-21 76.2 0.0 3.3e-21 75.0 0.0 1.7 1 1 0 1 1 1 1 STAS domain DUF2564 PF10819.6 NM_001040454.1_3 - 0.82 10.0 3.7 1.8 8.9 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2564) Sod_Fe_C PF02777.16 NM_000636.3_3 - 9.4e-38 128.4 0.0 1.6e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.20 NM_000636.3_3 - 7.1e-32 109.6 3.2 1.3e-31 108.7 3.2 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain JSRP PF15312.4 NM_144616.3_3 - 2.4e-28 97.8 4.2 2.4e-28 97.8 4.2 4.4 5 1 1 6 6 6 1 Junctional sarcoplasmic reticulum protein Radical_SAM PF04055.19 NM_016082.4_3 - 7.9e-31 107.5 0.0 1.7e-30 106.5 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.18 NM_016082.4_3 - 2.2e-30 104.5 0.0 4.5e-30 103.5 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.18 NM_016082.4_3 - 2.6e-12 46.4 0.0 4.9e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 TRAM domain zf-H2C2_2 PF13465.4 NM_152736.5_1 - 2.3e-35 119.3 74.3 3.1e-08 33.6 0.7 10.9 10 1 0 10 10 10 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_152736.5_1 - 3.2e-33 112.2 70.0 4.1e-05 23.7 0.1 9.5 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_152736.5_1 - 2.7e-15 55.6 73.4 0.0045 17.6 0.1 8.9 10 0 0 10 10 7 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_152736.5_1 - 2.5e-07 30.5 26.9 0.0027 17.7 0.5 5.4 5 1 0 5 5 5 3 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_152736.5_1 - 1.4e-06 27.8 42.6 0.093 12.4 3.2 6.9 6 0 0 6 6 6 5 zinc-finger C2H2-type XPA_N PF01286.16 NM_152736.5_1 - 7.9e-06 25.7 21.3 0.16 11.9 0.6 7.2 7 0 0 7 7 7 2 XPA protein N-terminal ADK_lid PF05191.12 NM_152736.5_1 - 0.02 14.8 8.1 6 6.8 0.5 4.8 2 2 2 4 4 4 0 Adenylate kinase, active site lid zf-C2H2_6 PF13912.4 NM_152736.5_1 - 0.067 13.0 60.8 0.18 11.6 0.1 9.6 9 1 0 9 9 9 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 NM_152736.5_1 - 0.24 12.0 31.8 0.71 10.5 1.4 4.8 1 1 6 7 7 7 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_152736.5_1 - 0.35 11.1 24.6 1.1 9.5 0.3 6.3 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding DUF2197 PF09963.7 NM_152736.5_1 - 2.3 8.4 7.1 0.31 11.2 0.4 3.0 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2197) C1_4 PF07975.10 NM_152736.5_1 - 3.6 7.8 34.7 3.1 8.0 0.8 5.4 4 1 1 5 5 5 0 TFIIH C1-like domain YhfH PF14149.4 NM_152736.5_1 - 4.3 7.3 25.6 16 5.4 0.2 6.4 6 0 0 6 6 6 0 YhfH-like protein MFS_1 PF07690.14 NM_001319220.1_1 - 4.3e-19 68.5 23.1 4.5e-12 45.4 7.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily 7tm_1 PF00001.19 NM_001160166.1_2 - 1.4e-05 24.3 0.4 1.4e-05 24.3 0.4 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.19 NM_001160166.1_3 - 1.4e-22 80.1 3.8 1.4e-22 80.1 3.8 1.7 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) BK_channel_a PF03493.16 NM_001271518.1_1 - 3.1e-32 110.6 0.2 6.1e-32 109.6 0.2 1.5 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.29 NM_001271518.1_1 - 3.2e-17 62.5 19.1 7.1e-17 61.3 19.1 1.5 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 NM_001271518.1_1 - 9.8e-14 51.0 4.1 2.8e-13 49.5 4.1 1.8 1 0 0 1 1 1 1 Ion channel TrkA_N PF02254.16 NM_001271518.1_1 - 0.0002 21.4 0.0 0.00061 19.9 0.0 1.7 2 0 0 2 2 2 1 TrkA-N domain Trypsin PF00089.24 NM_001170423.1_1 - 1.9e-10 40.8 0.0 8e-09 35.5 0.0 2.3 2 0 0 2 2 2 1 Trypsin Trypsin_2 PF13365.4 NM_001170423.1_1 - 2.7e-05 25.0 0.0 6e-05 23.8 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain TRAPPC-Trs85 PF12739.5 NM_014939.3_2 - 7e-163 542.0 3.8 1.2e-162 541.3 3.8 1.4 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit SNAP PF14938.4 NM_014939.3_2 - 0.23 10.7 5.6 0.11 11.8 1.0 2.3 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP SPC12 PF06645.11 NM_014041.3_2 - 1.3e-29 102.0 1.8 1.9e-29 101.4 1.8 1.3 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF1440 PF07274.10 NM_014041.3_2 - 0.012 15.9 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1440) RnaseA PF00074.18 NM_002935.2_1 - 7.6e-32 110.3 2.5 9.1e-32 110.0 2.5 1.1 1 0 0 1 1 1 1 Pancreatic ribonuclease Y_phosphatase PF00102.25 NM_030667.2_3 - 1.6e-83 279.8 2.0 2.9e-83 278.9 2.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.19 NM_030667.2_3 - 8.5e-24 83.6 18.0 3.4e-07 30.4 1.0 6.9 7 0 0 7 7 7 4 Fibronectin type III domain Y_phosphatase3 PF13350.4 NM_030667.2_3 - 9.5e-05 22.3 0.0 0.00016 21.6 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 NM_030667.2_3 - 0.00015 21.5 0.0 0.0005 19.7 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 NM_030667.2_3 - 0.0013 18.8 0.1 0.0035 17.4 0.1 1.7 1 1 0 1 1 1 1 Inositol hexakisphosphate Pur_ac_phosph_N PF16656.3 NM_030667.2_3 - 0.0052 17.2 3.6 4 7.9 0.2 3.9 3 1 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain PDEase_I PF00233.17 NM_001322056.1_2 - 9.3e-81 270.9 4.3 1.4e-80 270.3 4.3 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.10 NM_001322056.1_2 - 8.1e-31 105.5 0.1 1.6e-30 104.6 0.1 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal Glyco_transf_29 PF00777.16 NM_001271145.1_2 - 2.5e-57 194.1 0.0 3.6e-57 193.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Tyrosinase PF00264.18 NM_001322186.1_3 - 2.6e-32 112.8 0.1 3.4e-32 112.4 0.1 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase PetG PF02529.13 NM_001322186.1_3 - 0.062 13.0 1.9 0.17 11.6 1.9 1.7 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit 5 DUF4962 PF16332.3 NM_001322939.1_3 - 1.1e-07 30.7 4.3 1.1e-07 30.7 4.3 1.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4962) Hepar_II_III PF07940.11 NM_001322939.1_3 - 0.034 13.7 0.0 3.9 6.9 0.0 2.5 2 1 0 2 2 2 0 Heparinase II/III-like protein PPDFL PF15060.4 NM_001256598.1_1 - 4e-16 59.4 0.4 7.6e-16 58.5 0.4 1.4 1 0 0 1 1 1 1 Differentiation and proliferation regulator Cadherin PF00028.15 NM_022124.5_1 - 0 1437.2 25.3 1.3e-19 70.3 0.0 27.3 26 1 1 27 27 27 27 Cadherin domain Cadherin_2 PF08266.10 NM_022124.5_1 - 7.2e-27 92.9 0.0 0.15 11.8 0.0 15.0 17 0 0 17 17 17 8 Cadherin-like Cadherin_3 PF16184.3 NM_022124.5_1 - 3.7e-18 65.4 37.5 0.0076 16.1 0.0 19.0 21 0 0 21 21 21 6 Cadherin-like Cadherin_pro PF08758.9 NM_022124.5_1 - 1.5e-07 31.3 0.0 5.6 7.1 0.0 8.8 10 0 0 10 10 10 1 Cadherin prodomain like DUF3364 PF11844.6 NM_022124.5_1 - 9.9 6.4 7.4 20 5.4 0.1 4.6 5 0 0 5 5 5 0 Domain of unknown function (DUF3364) Voltage_CLC PF00654.18 NM_001243372.1_2 - 1.9e-87 293.7 14.1 2.8e-63 214.2 8.6 2.2 1 1 1 2 2 2 2 Voltage gated chloride channel CBS PF00571.26 NM_001243372.1_2 - 4.2e-12 46.2 0.6 2.1e-06 28.0 0.1 2.4 2 0 0 2 2 2 2 CBS domain Ig_2 PF13895.4 NM_213633.2_2 - 2e-26 92.0 0.8 1.8e-14 53.7 0.4 3.6 3 1 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 NM_213633.2_2 - 2.1e-26 92.2 3.0 3.5e-09 37.0 0.1 3.7 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.14 NM_213633.2_2 - 1.2e-15 57.2 0.0 0.00038 20.3 0.0 4.4 3 1 0 3 3 3 3 Immunoglobulin I-set domain V-set PF07686.15 NM_213633.2_2 - 1.7e-15 57.0 0.1 3.2e-10 40.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.23 NM_213633.2_2 - 2.9e-15 56.1 0.5 0.00064 19.7 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_5 PF16681.3 NM_213633.2_2 - 0.00032 20.9 0.0 0.024 14.9 0.1 2.5 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Mg_trans_NIPA PF05653.12 NM_001322865.1_2 - 3e-41 141.3 8.3 4e-41 140.9 8.3 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.18 NM_001322865.1_2 - 0.081 13.0 17.8 1.2 9.2 4.1 2.6 1 1 1 2 2 2 0 EamA-like transporter family Serinc PF03348.13 NM_001322865.1_2 - 0.52 9.1 7.8 0.49 9.1 4.5 1.9 2 0 0 2 2 2 0 Serine incorporator (Serinc) Bax1-I PF01027.18 NM_001322865.1_2 - 4.6 6.9 15.3 0.023 14.4 2.7 2.2 1 1 1 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 PI3K_1B_p101 PF10486.7 NM_001251851.1_1 - 6.2e-243 808.3 0.0 7.9e-243 807.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF2284 PF10050.7 NM_001251851.1_1 - 0.028 14.1 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) PI3K_1B_p101 PF10486.7 NM_001251851.1_2 - 3.4e-138 461.7 0.0 4.4e-138 461.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sulfotransfer_1 PF00685.25 NM_177536.3_3 - 7.6e-55 186.1 3.2 9.8e-55 185.7 3.2 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_177536.3_3 - 0.00016 22.0 0.1 0.00026 21.3 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Pkinase_Tyr PF07714.15 NM_005235.2_3 - 2.8e-91 305.3 0.0 3.8e-91 304.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 NM_005235.2_3 - 2.4e-59 198.2 3.1 1e-30 106.0 0.2 2.4 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 NM_005235.2_3 - 5.7e-51 171.6 79.8 4.4e-46 155.8 27.9 3.6 2 1 1 3 3 3 2 Growth factor receptor domain IV Pkinase PF00069.23 NM_005235.2_3 - 8e-39 133.4 0.0 1.1e-38 133.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 NM_005235.2_3 - 2.4e-34 118.2 85.5 2e-28 99.0 41.0 4.4 2 1 2 4 4 4 3 Furin-like cysteine rich region APH PF01636.21 NM_005235.2_3 - 0.046 13.5 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_005235.2_3 - 0.088 12.0 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like CTD_bind PF04818.11 NM_001297673.1_2 - 1.4e-16 60.9 0.3 3.4e-16 59.7 0.3 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CREPT PF16566.3 NM_001297673.1_2 - 1.2e-07 31.9 0.5 2.2e-07 31.0 0.5 1.3 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour nec1 PF10379.7 NM_001297673.1_2 - 0.071 12.5 0.2 0.17 11.3 0.2 1.6 1 0 0 1 1 1 0 Virulence protein nec1 RasGAP PF00616.17 NM_001285462.1_1 - 5.6e-58 195.9 0.0 5.6e-58 195.9 0.0 3.0 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.13 NM_001285462.1_1 - 9.6e-39 132.5 10.6 9.6e-39 132.5 10.6 3.4 3 0 0 3 3 3 1 RasGAP C-terminus IQ PF00612.25 NM_001285462.1_1 - 9.6e-10 37.3 3.4 0.0019 17.7 0.1 3.9 4 0 0 4 4 4 3 IQ calmodulin-binding motif WW PF00397.24 NM_001285462.1_1 - 0.45 10.4 2.9 0.95 9.3 2.9 1.5 1 0 0 1 1 1 0 WW domain Peptidase_C26 PF07722.11 NM_003878.2_2 - 4.8e-24 85.2 0.0 1.4e-23 83.6 0.0 1.7 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.26 NM_003878.2_2 - 4.1e-07 29.8 0.0 7.3e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I DUF167 PF02594.14 NM_144597.2_2 - 6.4e-25 86.9 0.6 1.2e-24 86.1 0.6 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 ThiP_synth PF10120.7 NM_144597.2_2 - 0.12 11.8 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Thiamine-phosphate synthase MTCP1 PF08991.8 NM_001018024.2_2 - 9.9e-18 64.0 11.8 1.5e-17 63.4 11.8 1.3 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type NDUF_B7 PF05676.11 NM_001018024.2_2 - 0.052 13.1 3.3 0.11 12.1 3.3 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CHCH PF06747.11 NM_001018024.2_2 - 6 7.0 12.6 9.7 6.3 12.6 1.3 1 0 0 1 1 1 0 CHCH domain Toluene_X PF03349.14 NM_001321395.1_1 - 0.066 11.6 0.1 0.092 11.1 0.1 1.1 1 0 0 1 1 1 0 Outer membrane protein transport protein (OMPP1/FadL/TodX) HEAT_2 PF13646.4 NM_001321395.1_3 - 1.1e-13 51.2 2.2 4.9e-05 23.5 0.2 3.9 1 1 4 5 5 5 4 HEAT repeats DUF3385 PF11865.6 NM_001321395.1_3 - 0.011 15.5 5.4 0.78 9.4 1.4 3.7 2 2 0 2 2 2 0 Domain of unknown function (DUF3385) HEAT PF02985.20 NM_001321395.1_3 - 0.15 12.2 2.2 60 4.1 0.0 4.8 5 0 0 5 5 5 0 HEAT repeat SSF PF00474.15 NM_001258413.2_1 - 2.3e-141 471.2 20.2 3.5e-141 470.6 20.2 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family Helicase_C PF00271.29 NM_001289072.1_3 - 2.8e-22 79.0 0.6 1.1e-21 77.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.21 NM_001289072.1_3 - 2.7e-21 75.6 5.5 6.4e-14 51.3 0.0 3.0 2 1 1 3 3 3 2 SNF2 family N-terminal domain Shugoshin_C PF07557.9 NM_001289072.1_3 - 0.1 12.3 1.9 0.27 11.0 1.9 1.7 1 0 0 1 1 1 0 Shugoshin C terminus LRR_8 PF13855.4 NM_001318811.1_2 - 7e-49 163.3 65.5 5.2e-13 48.4 2.5 7.6 4 2 6 10 10 10 8 Leucine rich repeat LRR_5 PF13306.4 NM_001318811.1_2 - 7.2e-19 67.9 2.3 1.3e-08 34.7 0.1 3.0 2 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_001318811.1_2 - 6e-17 61.3 33.2 3.4e-05 24.0 2.7 7.4 5 2 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_001318811.1_2 - 3.4e-07 29.8 14.4 0.0015 18.0 0.1 4.1 2 2 2 4 4 4 4 Leucine-rich repeat LRRNT PF01462.16 NM_001318811.1_2 - 0.02 14.4 0.8 0.02 14.4 0.8 2.5 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Pex14_N PF04695.11 NM_001318811.1_2 - 0.028 15.0 1.4 0.063 13.9 1.4 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Perilipin PF03036.14 NM_002666.4_2 - 6.1e-116 387.6 2.1 8.2e-116 387.2 2.1 1.2 1 0 0 1 1 1 1 Perilipin family GATA PF00320.25 NM_002051.2_3 - 2.1e-28 97.5 19.6 4e-14 51.8 5.3 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 NM_002051.2_3 - 0.00011 21.4 8.3 0.052 12.9 0.7 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.8 NM_002051.2_3 - 0.086 12.9 2.0 6.3 6.9 0.1 2.7 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.5 NM_002051.2_3 - 1.8 8.5 10.1 9.4 6.2 1.6 3.0 1 1 2 3 3 3 0 Double zinc ribbon Pcc1 PF09341.8 NM_020994.4_2 - 0.00033 20.6 0.0 0.00052 20.0 0.0 1.3 1 0 0 1 1 1 1 Transcription factor Pcc1 Peptidase_M19 PF01244.19 NM_022357.3_2 - 1.6e-101 339.5 0.0 2e-101 339.2 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) PEX11 PF05648.12 NM_001270539.1_2 - 1.5e-41 142.2 0.0 1.8e-41 141.9 0.0 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Pox_A_type_inc PF04508.10 NM_182791.3_2 - 6.4 6.7 8.6 0.49 10.2 0.3 2.9 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat G6B PF15096.4 NM_138274.2_2 - 2.7e-73 246.3 2.0 4.1e-73 245.7 2.0 1.2 1 0 0 1 1 1 1 G6B family G6B PF15096.4 NM_138274.2_3 - 5.7e-25 88.2 0.0 9.2e-25 87.6 0.0 1.3 1 0 0 1 1 1 1 G6B family Myb_DNA-bind_2 PF08914.9 NM_018975.3_3 - 2.6e-31 107.5 0.2 4.7e-31 106.6 0.2 1.4 1 0 0 1 1 1 1 Rap1 Myb domain BRCT_2 PF16589.3 NM_018975.3_3 - 1.1e-15 57.6 0.0 3.1e-15 56.2 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Rap1_C PF11626.6 NM_018975.3_3 - 7.8e-12 45.0 0.2 5.4e-11 42.3 0.1 2.2 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_6 PF13921.4 NM_018975.3_3 - 0.084 13.0 0.1 0.74 10.0 0.1 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain DUF1220 PF06758.11 NM_001256416.2_3 - 3.3e-100 328.3 57.2 6.2e-27 93.6 6.8 7.0 6 1 0 6 6 6 5 Repeat of unknown function (DUF1220) GAT PF03127.12 NM_001256416.2_3 - 0.17 12.1 3.9 0.094 12.9 1.2 2.1 2 0 0 2 2 2 0 GAT domain APP_E2 PF12925.5 NM_001204301.1_3 - 6.9e-74 247.5 20.3 1.1e-73 246.9 20.3 1.3 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 NM_001204301.1_3 - 1.1e-43 147.5 0.5 1.1e-43 147.5 0.5 2.1 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding Beta-APP PF03494.11 NM_001204301.1_3 - 1.1e-26 92.3 1.7 1.8e-26 91.6 1.7 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) APP_Cu_bd PF12924.5 NM_001204301.1_3 - 2.3e-25 89.0 7.9 2.9e-25 88.6 4.7 2.8 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.7 NM_001204301.1_3 - 2.5e-25 88.6 0.3 1e-24 86.7 0.3 2.1 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus Kunitz_BPTI PF00014.21 NM_001204301.1_3 - 1.8e-19 69.6 6.5 3.9e-19 68.5 6.5 1.6 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Mod_r PF07200.11 NM_001204301.1_3 - 1.8 8.5 13.2 0.19 11.7 7.5 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein PilJ PF13675.4 NM_001204301.1_3 - 3 7.8 6.8 0.52 10.2 1.9 2.2 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term ERbeta_N PF12497.6 NM_001271877.1_1 - 2.8e-51 171.9 6.1 4.8e-51 171.2 6.1 1.4 1 0 0 1 1 1 1 Estrogen receptor beta zf-C4 PF00105.16 NM_001271877.1_1 - 8.6e-32 109.3 14.2 3.7e-31 107.3 13.1 2.3 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001271877.1_1 - 3.9e-08 33.0 2.2 0.0013 18.3 0.4 2.3 1 1 1 2 2 2 2 Ligand-binding domain of nuclear hormone receptor Pkinase PF00069.23 NM_001321224.1_1 - 1.4e-41 142.5 0.4 2.9e-41 141.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001321224.1_1 - 3.2e-28 98.6 0.1 7.3e-28 97.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.21 NM_001321224.1_1 - 0.0024 17.7 0.6 0.0064 16.3 0.0 1.9 3 0 0 3 3 3 1 Phosphotransferase enzyme family Lectin_C PF00059.19 NM_001321308.1_3 - 1e-23 84.0 17.5 2e-18 66.9 1.5 3.4 2 2 2 4 4 2 2 Lectin C-type domain HMMR_N PF15905.3 NM_001321308.1_3 - 2e-09 37.2 33.5 0.00075 18.9 15.7 3.5 1 1 2 3 3 3 3 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.9 NM_001321308.1_3 - 2.1e-07 30.0 37.2 0.0001 21.2 4.0 3.2 1 1 2 3 3 3 2 Spc7 kinetochore protein Phage_GP20 PF06810.9 NM_001321308.1_3 - 8e-05 22.3 34.1 0.00047 19.9 4.2 4.7 1 1 4 6 6 6 3 Phage minor structural protein GP20 RPW8 PF05659.9 NM_001321308.1_3 - 0.00025 20.6 19.4 0.094 12.3 5.9 5.7 1 1 5 6 6 6 2 Arabidopsis broad-spectrum mildew resistance protein RPW8 CENP-F_leu_zip PF10473.7 NM_001321308.1_3 - 0.00032 20.6 36.6 0.11 12.4 11.8 4.3 1 1 4 5 5 5 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.13 NM_001321308.1_3 - 0.00054 20.3 33.6 0.0032 17.8 8.2 3.4 1 1 3 4 4 4 3 Fez1 GAS PF13851.4 NM_001321308.1_3 - 0.00081 18.7 37.7 0.046 12.9 3.0 4.5 1 1 3 4 4 4 3 Growth-arrest specific micro-tubule binding DASH_Duo1 PF08651.8 NM_001321308.1_3 - 0.00099 18.7 31.8 0.021 14.4 1.5 7.3 4 2 2 6 6 6 1 DASH complex subunit Duo1 DUF2353 PF09789.7 NM_001321308.1_3 - 0.0022 17.3 6.1 0.0022 17.3 6.1 3.2 1 1 2 3 3 3 2 Uncharacterized coiled-coil protein (DUF2353) TBPIP PF07106.11 NM_001321308.1_3 - 0.0056 16.3 36.9 0.15 11.7 7.4 4.6 1 1 1 4 4 4 3 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Golgin_A5 PF09787.7 NM_001321308.1_3 - 0.013 14.8 41.1 0.14 11.5 5.5 3.2 1 1 3 4 4 4 0 Golgin subfamily A member 5 Tropomyosin_1 PF12718.5 NM_001321308.1_3 - 0.014 15.4 35.2 0.54 10.2 5.0 4.4 1 1 3 4 4 4 0 Tropomyosin like DUF2730 PF10805.6 NM_001321308.1_3 - 0.014 15.4 1.7 0.014 15.4 1.7 4.3 3 2 2 5 5 4 0 Protein of unknown function (DUF2730) CEP63 PF17045.3 NM_001321308.1_3 - 0.015 15.1 35.9 0.23 11.2 9.0 4.2 1 1 2 3 3 3 0 Centrosomal protein of 63 kDa Laminin_II PF06009.10 NM_001321308.1_3 - 0.032 14.1 35.3 0.14 12.0 5.8 4.9 1 1 4 5 5 5 0 Laminin Domain II DUF1579 PF07617.9 NM_001321308.1_3 - 0.035 13.9 0.4 0.17 11.7 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1579) LPP PF04728.11 NM_001321308.1_3 - 0.04 14.2 36.2 3.4 8.0 0.0 7.3 5 2 2 7 7 7 0 Lipoprotein leucine-zipper TPR_MLP1_2 PF07926.10 NM_001321308.1_3 - 0.067 13.1 45.0 0.38 10.7 1.8 5.6 1 1 5 6 6 6 0 TPR/MLP1/MLP2-like protein Xlink PF00193.15 NM_001321308.1_3 - 0.089 13.1 0.7 3.6 7.9 0.1 2.7 1 1 1 2 2 2 0 Extracellular link domain DUF4201 PF13870.4 NM_001321308.1_3 - 0.16 11.5 35.7 1.5 8.3 10.5 4.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4201) Fib_alpha PF08702.8 NM_001321308.1_3 - 0.44 10.6 34.8 0.27 11.3 4.6 5.1 1 1 5 6 6 6 0 Fibrinogen alpha/beta chain family MAD PF05557.11 NM_001321308.1_3 - 0.59 8.3 35.7 0.004 15.4 10.3 2.9 1 1 2 3 3 3 0 Mitotic checkpoint protein DUF641 PF04859.10 NM_001321308.1_3 - 0.7 10.1 26.3 12 6.1 0.4 6.0 1 1 6 7 7 7 0 Plant protein of unknown function (DUF641) Rootletin PF15035.4 NM_001321308.1_3 - 0.79 9.6 37.5 4.5 7.2 0.3 4.7 1 1 3 4 4 4 0 Ciliary rootlet component, centrosome cohesion AIP3 PF03915.11 NM_001321308.1_3 - 0.89 8.4 29.8 0.19 10.6 13.2 2.4 1 1 1 2 2 2 0 Actin interacting protein 3 MscS_porin PF12795.5 NM_001321308.1_3 - 0.93 8.8 55.3 0.24 10.8 11.9 3.2 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain Mnd1 PF03962.13 NM_001321308.1_3 - 2.1 8.0 32.3 1.4 8.6 5.2 4.0 1 1 2 3 3 2 0 Mnd1 family Seryl_tRNA_N PF02403.20 NM_001321308.1_3 - 3.9 7.6 27.3 0.26 11.4 7.2 4.3 1 1 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain CC2-LZ PF16516.3 NM_001321308.1_3 - 4.5 7.5 29.0 0.45 10.7 1.6 5.3 2 2 2 5 5 5 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF812 PF05667.9 NM_001321308.1_3 - 4.8 5.8 32.7 0.75 8.5 4.7 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF812) DUF2203 PF09969.7 NM_001321308.1_3 - 6 7.5 22.7 5.2 7.7 0.7 5.0 1 1 3 5 5 5 0 Uncharacterized conserved protein (DUF2203) DUF603 PF04645.10 NM_001321308.1_3 - 7.8 6.0 8.7 3 7.4 2.4 2.7 1 1 0 2 2 2 0 Protein of unknown function, DUF603 FlaC_arch PF05377.9 NM_001321308.1_3 - 8.2 6.8 23.0 37 4.7 0.3 7.4 5 2 1 6 6 6 0 Flagella accessory protein C (FlaC) ERM PF00769.17 NM_001321308.1_3 - 8.8 5.9 29.3 18 4.9 4.6 3.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Occludin_ELL PF07303.11 NM_001321308.1_3 - 9.5 6.9 13.3 19 5.9 3.5 4.9 1 1 4 6 6 6 0 Occludin homology domain ABC_transp_aux PF09822.7 NM_001323579.1_2 - 8.1e-10 38.5 0.1 1.1e-09 38.0 0.1 1.1 1 0 0 1 1 1 1 ABC-type uncharacterized transport system PI3Ka PF00613.18 NM_001308020.1_2 - 1.8e-57 193.6 1.6 3.3e-57 192.8 1.6 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.25 NM_001308020.1_2 - 3.3e-53 180.9 0.0 5.3e-37 127.8 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.22 NM_001308020.1_2 - 4e-36 123.9 0.0 7.9e-36 123.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 HEAT_2 PF13646.4 NM_001308020.1_2 - 0.0092 16.2 0.2 0.021 15.1 0.2 1.6 1 0 0 1 1 1 1 HEAT repeats DUF4135 PF13575.4 NM_001308020.1_2 - 0.011 14.9 0.0 0.023 13.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) MORN PF02493.18 NM_175913.3_1 - 4.9e-17 60.6 42.9 1.6e-06 27.6 3.2 6.3 5 0 0 5 5 5 5 MORN repeat TMEM213 PF15192.4 NM_175913.3_2 - 0.13 12.2 2.4 0.28 11.1 2.4 1.5 1 0 0 1 1 1 0 TMEM213 family AA_permease PF00324.19 NM_000339.2_3 - 1.1e-138 462.7 35.7 1.3e-138 462.4 35.7 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.13 NM_000339.2_3 - 1.7e-135 452.1 0.0 2.3e-82 277.1 0.0 2.1 1 1 1 2 2 2 2 Solute carrier family 12 AA_permease_N PF08403.8 NM_000339.2_3 - 9.5e-27 92.2 0.3 2.1e-26 91.1 0.3 1.6 1 0 0 1 1 1 1 Amino acid permease N-terminal DDDD PF10161.7 NM_000339.2_3 - 1.7 8.3 3.9 8.7 6.0 0.0 3.7 4 0 0 4 4 4 0 Putative mitochondrial precursor protein Ras PF00071.20 NM_032144.2_2 - 4.7e-48 162.7 0.1 6.9e-48 162.2 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_032144.2_2 - 6.2e-28 97.3 0.1 9e-28 96.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_032144.2_2 - 1e-09 38.0 0.1 1.7e-09 37.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 NM_032144.2_2 - 0.062 12.6 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NRIP1_repr_4 PF15690.3 NM_003489.3_2 - 3e-162 539.1 8.0 6.4e-162 538.0 8.0 1.6 1 0 0 1 1 1 1 Nuclear receptor-interacting protein 1 repression 4 NRIP1_repr_1 PF15687.3 NM_003489.3_2 - 1.2e-143 478.2 22.6 2.6e-143 477.2 22.6 1.6 1 0 0 1 1 1 1 Nuclear receptor-interacting protein 1 repression 1 NRIP1_repr_2 PF15688.3 NM_003489.3_2 - 1.5e-125 419.3 26.3 4.2e-125 417.8 26.3 1.8 1 0 0 1 1 1 1 Nuclear receptor-interacting protein 1 repression 2 NRIP1_repr_3 PF15689.3 NM_003489.3_2 - 5.4e-44 148.3 0.7 5.4e-44 148.3 0.7 2.8 3 0 0 3 3 3 1 Nuclear receptor-interacting protein 1 repression 3 Methyltrans_RNA PF04452.12 NM_003489.3_2 - 0.11 11.6 0.1 0.21 10.7 0.1 1.3 1 0 0 1 1 1 0 RNA methyltransferase DUF4602 PF15375.4 NM_152379.3_2 - 7.7e-34 116.8 17.6 7.7e-34 116.8 17.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4602) LRR_8 PF13855.4 NM_001080460.1_1 - 2.7e-51 171.0 51.8 3.6e-10 39.3 1.0 9.0 4 2 6 10 10 10 10 Leucine rich repeat LRR_4 PF12799.5 NM_001080460.1_1 - 5.1e-38 128.2 51.2 2.2e-06 27.7 0.6 10.9 8 3 3 11 11 11 11 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001080460.1_1 - 7.4e-06 25.6 60.0 1.6 9.4 0.3 15.8 16 3 1 17 17 17 5 Leucine Rich Repeat LRR_5 PF13306.4 NM_001080460.1_1 - 0.0015 18.4 0.4 15 5.4 0.1 3.8 3 1 0 4 4 4 1 Leucine rich repeats (6 copies) IQ PF00612.25 NM_001080460.1_1 - 0.002 17.6 0.4 0.0048 16.4 0.4 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif RsmF_methylt_CI PF17126.3 NM_001080460.1_1 - 0.0063 16.4 4.3 67 3.5 0.0 6.4 6 3 2 8 8 8 0 RsmF rRNA methyltransferase first C-terminal domain Claudin_2 PF13903.4 NM_145814.1_3 - 9.6e-29 100.4 1.0 1.5e-28 99.8 1.0 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 NM_145814.1_3 - 9.4e-05 22.2 3.8 0.13 11.9 0.1 2.2 2 0 0 2 2 2 2 PMP-22/EMP/MP20/Claudin family DUF1700 PF08006.9 NM_145814.1_3 - 0.17 11.3 1.5 0.27 10.6 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF1686 PF07937.9 NM_145814.1_3 - 0.19 11.4 1.0 0.32 10.7 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1686) VWA PF00092.26 NM_001278298.1_3 - 1.4e-280 920.8 46.6 2.7e-43 148.1 1.6 10.2 10 0 0 10 10 10 9 von Willebrand factor type A domain VWA_2 PF13519.4 NM_001278298.1_3 - 1.5e-100 331.0 13.8 4.9e-15 56.0 0.0 9.9 10 0 0 10 10 10 9 von Willebrand factor type A domain Collagen PF01391.16 NM_001278298.1_3 - 2.9e-44 148.5 170.5 1.8e-08 33.8 30.8 7.5 1 1 5 6 6 6 6 Collagen triple helix repeat (20 copies) VWA_CoxE PF05762.12 NM_001278298.1_3 - 2.8e-12 46.4 0.3 0.0093 15.2 0.0 5.3 5 1 0 5 5 5 3 VWA domain containing CoxE-like protein Copine PF07002.14 NM_001278298.1_3 - 6.1e-07 29.0 2.0 0.11 11.8 0.0 5.6 6 0 0 6 6 6 2 Copine Radical_SAM PF04055.19 NM_001278298.1_3 - 1.3e-06 28.8 0.8 8.3 6.6 0.0 6.9 8 0 0 8 8 8 1 Radical SAM superfamily vWA-TerF-like PF10138.7 NM_001278298.1_3 - 5.1e-05 23.3 8.6 0.00054 20.0 0.5 4.2 4 0 0 4 4 4 1 vWA found in TerF C terminus Integrin_beta PF00362.16 NM_001278298.1_3 - 1.9 7.9 15.4 0.22 11.0 0.1 4.8 5 1 0 5 5 5 0 Integrin beta chain VWA domain Ephrin_lbd PF01404.17 NM_182644.2_1 - 2.5e-70 236.0 0.1 4.5e-70 235.2 0.1 1.4 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain fn3 PF00041.19 NM_182644.2_1 - 9.5e-31 105.9 5.7 5e-15 55.5 0.4 2.8 3 0 0 3 3 3 2 Fibronectin type III domain Ephrin_rec_like PF07699.11 NM_182644.2_1 - 5.2e-07 29.2 3.9 5.2e-07 29.2 3.9 3.6 3 1 0 3 3 3 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.3 NM_182644.2_1 - 5.3e-07 30.0 0.2 0.00019 21.8 0.2 2.5 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 NM_182644.2_1 - 0.00041 20.3 0.4 0.45 10.6 0.0 2.8 3 0 0 3 3 3 2 Fibronectin type III domain DUF2369 PF10179.7 NM_182644.2_1 - 0.0051 17.1 0.5 2.4 8.5 0.1 2.5 1 1 1 2 2 2 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 NM_182644.2_1 - 0.045 13.9 0.0 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III SusE PF14292.4 NM_182644.2_1 - 0.067 13.5 0.1 0.47 10.7 0.1 2.3 2 0 0 2 2 2 0 SusE outer membrane protein cEGF PF12662.5 NM_182644.2_1 - 1 9.2 8.2 4 7.3 1.7 2.8 1 1 1 2 2 2 0 Complement Clr-like EGF-like DCX PF03607.15 NM_000555.3_2 - 2.5e-41 139.4 0.1 3.7e-21 74.9 0.0 2.4 2 0 0 2 2 2 2 Doublecortin DUF2457 PF10446.7 NM_000555.3_2 - 2.5 7.0 4.6 3.9 6.4 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) LRR_8 PF13855.4 NM_001144010.2_1 - 4e-43 144.9 45.4 2.4e-16 59.1 1.3 6.4 2 2 5 7 7 7 6 Leucine rich repeat LRR_5 PF13306.4 NM_001144010.2_1 - 2.8e-17 62.8 0.0 2.3e-07 30.7 0.0 2.3 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_001144010.2_1 - 7.6e-17 61.0 45.1 7.2e-05 22.9 0.6 8.5 7 1 0 8 8 8 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001144010.2_1 - 5.3e-05 23.0 30.2 3.7 8.3 0.0 10.6 10 1 0 10 10 10 2 Leucine Rich Repeat LRRNT PF01462.16 NM_001144010.2_1 - 0.001 18.5 9.0 0.0015 18.0 2.3 2.9 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 NM_001144010.2_1 - 0.0018 17.6 13.4 0.52 9.7 0.1 4.1 2 2 3 5 5 5 4 Leucine-rich repeat SET PF00856.26 NM_001323022.1_3 - 0.0006 20.1 0.3 0.00075 19.8 0.3 1.3 1 1 0 1 1 1 1 SET domain PRK PF00485.16 NM_012474.4_1 - 1.4e-51 174.9 0.1 1.9e-51 174.5 0.1 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CoaE PF01121.18 NM_012474.4_1 - 0.00011 21.8 0.1 0.00019 21.0 0.1 1.3 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.4 NM_012474.4_1 - 0.0014 19.0 0.0 0.0028 18.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 NM_012474.4_1 - 0.012 14.8 0.0 0.019 14.1 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.4 NM_012474.4_1 - 1.4 9.2 2.8 6.1 7.1 2.8 1.9 1 1 0 1 1 1 0 AAA domain REJ PF02010.13 NM_001278423.1_3 - 2.7e-07 29.6 0.0 3.7e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 REJ domain PAP_assoc PF03828.17 NM_018109.3_1 - 1.1e-05 25.4 0.9 4.9e-05 23.3 0.9 2.2 1 1 0 1 1 1 1 Cid1 family poly A polymerase Toxin_18 PF08087.9 NM_018109.3_3 - 0.63 10.0 9.8 5.9 6.8 1.5 3.1 2 0 0 2 2 2 0 Conotoxin O-superfamily SAM_1 PF00536.28 NM_001303614.1_3 - 1.7e-10 41.0 0.2 3e-10 40.3 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PHAT PF09246.8 NM_001303614.1_3 - 6e-08 32.3 0.0 0.007 16.1 0.0 3.2 3 0 0 3 3 3 3 PHAT SAM_2 PF07647.15 NM_001303614.1_3 - 0.00016 21.6 0.1 0.00034 20.5 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Methyltr_RsmB-F PF01189.15 NM_006170.3_2 - 8.8e-84 280.0 0.0 1.4e-83 279.3 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F P120R PF08062.9 NM_006170.3_2 - 8.1e-22 76.3 31.8 3.7e-08 33.2 1.1 4.0 3 0 0 3 3 3 3 P120R (NUC006) repeat Methyltr_RsmF_N PF17125.3 NM_006170.3_2 - 9.5e-10 38.7 0.0 2.6e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.17 NM_006170.3_2 - 0.0017 18.4 0.0 0.0034 17.4 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.17 NM_006170.3_2 - 0.0021 17.7 0.0 0.0042 16.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.4 NM_006170.3_2 - 0.0031 18.1 0.0 0.0072 16.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_006170.3_2 - 0.024 14.3 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Prefoldin_2 PF01920.18 NM_006170.3_2 - 0.039 13.8 0.5 0.36 10.7 0.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit DUF2431 PF10354.7 NM_006170.3_2 - 0.08 13.1 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) Met_10 PF02475.14 NM_006170.3_2 - 0.1 12.2 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_15 PF09445.8 NM_006170.3_2 - 0.17 11.5 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase IBN_N PF03810.17 NM_006390.3_1 - 2.4e-20 72.1 0.0 4.7e-19 68.0 0.0 3.0 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.8 NM_006390.3_1 - 4e-07 29.0 2.2 4e-07 29.0 2.2 2.8 2 1 1 3 3 3 1 Cse1 Xpo1 PF08389.10 NM_006390.3_1 - 0.31 11.0 10.9 0.092 12.7 0.9 3.7 4 0 0 4 4 4 0 Exportin 1-like protein HAND PF09110.9 NM_006390.3_1 - 1.8 9.2 6.4 0.46 11.1 0.2 2.3 2 0 0 2 2 2 0 HAND RGS PF00615.17 NM_002925.3_1 - 2e-32 111.8 6.9 3.8e-32 110.9 6.9 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.9 NM_002925.3_1 - 0.0041 16.7 0.2 0.0062 16.1 0.2 1.4 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain FliL PF03748.12 NM_002925.3_1 - 0.41 11.1 2.1 2.5 8.6 0.4 2.6 1 1 2 3 3 3 0 Flagellar basal body-associated protein FliL 7tm_1 PF00001.19 NM_001271854.1_3 - 1.3e-24 86.7 22.8 2.1e-24 86.1 22.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Neur_chan_LBD PF02931.21 NM_001256704.1_3 - 1.1e-50 171.9 0.4 1.8e-50 171.3 0.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_001256704.1_3 - 1.1e-35 123.7 6.2 3.5e-30 105.7 3.6 2.2 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region IL1 PF00340.17 NM_173170.1_2 - 3.4e-19 68.6 0.0 5.6e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 zf-C2H2_4 PF13894.4 NM_182581.3_2 - 0.24 12.2 1.4 0.93 10.4 1.4 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger CDK2AP PF09806.7 NM_004642.3_1 - 1.6e-19 70.8 0.0 2.2e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein Mem_trans PF03547.16 NM_001033045.3_1 - 3.8e-18 64.9 18.4 4.6e-12 44.9 5.5 2.4 1 1 1 2 2 2 2 Membrane transport protein DEP PF00610.19 NM_001033045.3_1 - 1.8e-13 50.2 0.0 5e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SNF2_N PF00176.21 NM_173082.3_1 - 7.3e-122 406.3 0.1 7.3e-122 406.3 0.1 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Linker_histone PF00538.17 NM_173082.3_1 - 1.4e-17 63.7 0.0 5.4e-17 61.8 0.0 2.1 1 0 0 1 1 1 1 linker histone H1 and H5 family Helicase_C PF00271.29 NM_173082.3_1 - 6.1e-08 32.9 0.0 1.8e-07 31.3 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 NM_173082.3_1 - 3.1e-06 26.8 9.1 3.1e-06 26.8 9.1 3.5 2 1 0 2 2 1 1 PHD-finger zf-RING_UBOX PF13445.4 NM_173082.3_1 - 6.2e-05 22.8 7.2 6.2e-05 22.8 7.2 2.4 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_173082.3_1 - 0.00017 21.3 10.3 0.00017 21.3 10.3 3.4 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_173082.3_1 - 0.00025 21.1 30.4 0.00049 20.2 10.9 4.4 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.23 NM_173082.3_1 - 0.00056 19.6 10.9 0.00056 19.6 10.9 3.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_173082.3_1 - 0.0025 17.6 10.4 0.0025 17.6 10.4 4.3 4 1 0 4 4 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.4 NM_173082.3_1 - 0.0027 17.4 5.0 0.0027 17.4 5.0 3.2 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_173082.3_1 - 0.22 11.3 15.0 0.25 11.1 9.9 3.5 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 Ion_trans PF00520.29 NM_002236.4_2 - 3.3e-47 160.6 7.6 4.2e-47 160.3 7.6 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_002236.4_2 - 4.8e-19 68.4 0.0 1e-18 67.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_002236.4_2 - 1.3e-12 47.4 2.3 2.9e-12 46.2 2.3 1.6 1 0 0 1 1 1 1 Ion channel PKD_channel PF08016.10 NM_002236.4_2 - 0.0045 15.6 5.2 0.0069 15.0 5.2 1.3 1 0 0 1 1 1 1 Polycystin cation channel ApoLp-III PF07464.9 NM_001166034.1_2 - 5.1e-05 23.3 0.0 0.3 11.1 0.1 3.3 3 1 1 4 4 4 2 Apolipophorin-III precursor (apoLp-III) DUF948 PF06103.9 NM_001166034.1_2 - 0.00046 20.3 0.4 4 7.6 0.1 4.8 3 2 2 5 5 5 1 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.10 NM_001166034.1_2 - 0.16 11.9 2.7 1.8 8.5 0.0 3.5 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) DUF883 PF05957.11 NM_001166034.1_2 - 0.54 10.8 14.6 7.3 7.1 1.5 5.7 1 1 1 5 5 5 0 Bacterial protein of unknown function (DUF883) Peptidase_S68 PF10461.7 NM_001166034.1_3 - 5.3 7.2 10.3 2.9e+02 1.7 0.0 7.0 9 0 0 9 9 9 0 Peptidase S68 zf-H2C2_2 PF13465.4 NM_001322138.1_2 - 2.9e-146 469.9 147.8 4.3e-08 33.1 1.0 21.9 21 0 0 21 21 21 21 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001322138.1_2 - 9.5e-116 372.1 157.2 8e-07 29.0 1.0 20.6 20 0 0 20 20 20 20 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001322138.1_2 - 7.7e-54 175.5 145.7 0.0028 18.2 0.4 20.8 20 0 0 20 20 20 20 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001322138.1_2 - 8.1e-32 108.4 136.1 0.0097 15.7 0.7 22.2 20 3 0 20 20 20 17 C2H2-type zinc finger KRAB PF01352.25 NM_001322138.1_2 - 1.5e-25 88.4 0.1 2.7e-25 87.6 0.1 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001322138.1_2 - 1.3e-24 85.9 102.0 0.029 14.3 2.8 16.5 4 3 15 20 20 20 17 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001322138.1_2 - 5.4e-21 73.9 84.1 0.43 10.2 0.1 20.1 20 0 0 20 20 20 9 zinc-finger C2H2-type XPA_N PF01286.16 NM_001322138.1_2 - 7.6e-17 60.9 61.2 9.5 6.2 0.0 20.0 20 0 0 20 20 20 0 XPA protein N-terminal C1_1 PF00130.20 NM_001322138.1_2 - 2.4e-13 49.6 69.8 0.17 11.6 0.9 14.0 1 1 17 18 18 18 13 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.3 NM_001322138.1_2 - 6.4e-09 36.3 83.2 0.38 11.4 0.6 10.8 1 1 13 15 15 15 14 zinc-ribbon family C1_4 PF07975.10 NM_001322138.1_2 - 6.3e-06 26.2 84.2 0.038 14.1 0.9 12.7 3 2 8 14 14 14 5 TFIIH C1-like domain HypA PF01155.17 NM_001322138.1_2 - 2.4e-05 24.2 71.2 2.1 8.2 0.9 10.8 1 1 10 11 11 11 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FAM178 PF14816.4 NM_001322138.1_2 - 0.00016 20.6 14.2 17 4.1 0.1 9.2 1 1 6 11 11 11 0 Family of unknown function, FAM178 zf-C2H2_jaz PF12171.6 NM_001322138.1_2 - 0.02 15.1 86.5 4.3 7.6 0.4 19.3 20 0 0 20 20 20 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_001322138.1_2 - 0.025 14.8 71.4 0.36 11.0 1.5 10.1 3 2 5 12 12 12 0 zinc-finger-containing domain tRNA-synt_2d PF01409.18 NM_001322138.1_2 - 0.93 8.8 10.4 10 5.4 0.1 5.2 5 2 3 8 8 8 0 tRNA synthetases class II core domain (F) FYDLN_acid PF09538.8 NM_001322138.1_2 - 6.9 7.3 44.9 32 5.1 0.1 14.0 1 1 15 16 16 16 0 Protein of unknown function (FYDLN_acid) ZZ PF00569.15 NM_001322138.1_2 - 8.2 6.2 93.8 12 5.6 0.3 19.3 20 0 0 20 20 20 0 Zinc finger, ZZ type ADK_lid PF05191.12 NM_001322138.1_2 - 9.4 6.2 71.6 2.6 8.0 0.8 11.6 2 1 10 13 13 12 0 Adenylate kinase, active site lid Corona_7 PF02398.14 NM_001322138.1_3 - 2.7 8.5 12.0 63 4.1 0.0 6.0 7 1 0 7 7 7 0 Coronavirus protein 7 MMADHC PF10229.7 NM_015702.2_2 - 4.8e-130 433.0 0.0 5.8e-130 432.8 0.0 1.0 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein Ribosomal_L19e PF01280.18 NM_000981.3_3 - 4.8e-67 224.4 12.5 4.8e-67 224.4 12.5 1.9 1 1 1 2 2 2 1 Ribosomal protein L19e CTP_transf_1 PF01148.18 NM_001263.3_1 - 1.6e-85 287.0 20.4 2.1e-85 286.6 20.4 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Septin PF00735.16 NM_001321031.1_3 - 1.6e-126 421.1 0.1 2.1e-126 420.7 0.1 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 NM_001321031.1_3 - 5.1e-07 29.7 0.0 1.1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_001321031.1_3 - 6.1e-05 22.9 0.2 0.004 17.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_001321031.1_3 - 6.5e-05 22.4 0.1 0.015 14.7 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.14 NM_001321031.1_3 - 0.0012 18.1 0.0 0.0024 17.1 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Ras PF00071.20 NM_001321031.1_3 - 0.0037 16.7 0.0 0.0063 16.0 0.0 1.3 1 0 0 1 1 1 1 Ras family Dynamin_N PF00350.21 NM_001321031.1_3 - 0.007 16.3 0.1 0.33 10.9 0.0 2.4 1 1 1 2 2 2 1 Dynamin family Roc PF08477.11 NM_001321031.1_3 - 0.029 14.5 0.0 0.052 13.7 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_001321031.1_3 - 0.029 14.6 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 NM_001321031.1_3 - 0.041 14.0 0.1 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.4 NM_001321031.1_3 - 0.047 13.3 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 NM_001321031.1_3 - 0.06 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter RhoGAP PF00620.25 NM_001287600.1_1 - 1.6e-16 60.3 0.7 2.5e-16 59.7 0.1 1.6 2 0 0 2 2 2 1 RhoGAP domain RhoGAP PF00620.25 NM_001287600.1_2 - 0.0021 17.8 0.0 0.0032 17.2 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Pkinase PF00069.23 NM_001276718.1_1 - 9.2e-51 172.6 0.1 2.2e-45 155.0 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001276718.1_1 - 4.6e-32 111.2 0.1 6.7e-32 110.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 NM_001276718.1_1 - 1.3e-15 57.4 0.1 2.6e-15 56.4 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 NM_001276718.1_1 - 7.1e-05 22.1 0.1 0.00011 21.5 0.1 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001276718.1_1 - 0.11 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ECH_1 PF00378.18 NM_001698.2_3 - 6.4e-57 192.6 0.0 9.3e-57 192.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 NM_001698.2_3 - 3.8e-27 95.5 0.1 1.3e-26 93.8 0.1 1.6 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase RWD PF05773.20 NM_016104.3_1 - 0.00072 19.7 0.0 0.0017 18.5 0.0 1.6 1 0 0 1 1 1 1 RWD domain RWD PF05773.20 NM_016104.3_3 - 9.5e-16 58.0 0.1 2.1e-15 56.9 0.1 1.6 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.3 NM_016104.3_3 - 7.8e-07 29.4 3.7 7.8e-07 29.4 3.7 2.4 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 BUD22 PF09073.8 NM_016104.3_3 - 0.47 9.6 12.2 0.63 9.2 12.2 1.1 1 0 0 1 1 1 0 BUD22 Hormone_6 PF00236.16 NM_130769.3_2 - 0.00033 20.4 5.6 0.00059 19.6 5.6 1.4 1 0 0 1 1 1 1 Glycoprotein hormone DAN PF03045.13 NM_130769.3_2 - 0.00048 20.0 8.1 0.00075 19.3 8.1 1.3 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.20 NM_130769.3_2 - 0.0036 17.4 8.7 0.0062 16.7 8.7 1.4 1 0 0 1 1 1 1 Cystine-knot domain I-set PF07679.14 NM_001256268.1_3 - 1.6e-100 329.2 0.0 1.6e-20 72.8 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001256268.1_3 - 1.8e-71 236.6 0.4 2.1e-13 50.6 0.0 7.1 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 NM_001256268.1_3 - 2.6e-44 149.1 1.5 1.5e-09 37.8 0.0 6.6 6 0 0 6 6 6 5 Immunoglobulin domain Ig_2 PF13895.4 NM_001256268.1_3 - 4.6e-43 145.3 1.1 4.1e-09 36.5 0.0 6.5 6 0 0 6 6 6 5 Immunoglobulin domain V-set PF07686.15 NM_001256268.1_3 - 4.5e-16 58.8 6.6 0.02 14.9 0.0 8.2 6 4 1 7 7 7 4 Immunoglobulin V-set domain C1-set PF07654.13 NM_001256268.1_3 - 1e-07 32.2 0.7 0.11 12.8 0.0 5.2 5 0 0 5 5 5 2 Immunoglobulin C1-set domain C2-set_2 PF08205.10 NM_001256268.1_3 - 1.8e-07 31.0 0.6 0.42 10.6 0.0 4.5 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 NM_001256268.1_3 - 0.00035 20.4 0.0 11 6.0 0.0 3.7 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 NM_001256268.1_3 - 0.00072 19.6 0.7 0.97 9.5 0.0 4.8 5 0 0 5 5 5 1 Natural killer cell receptor 2B4 BiPBP_C PF06832.10 NM_001256268.1_3 - 0.034 14.1 0.0 3.4 7.7 0.0 3.2 3 0 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family C2-set PF05790.13 NM_001256268.1_3 - 0.039 14.0 0.1 21 5.2 0.0 3.4 2 0 0 2 2 2 0 Immunoglobulin C2-set domain EGF_CA PF07645.13 NM_001042545.1_3 - 2.4e-142 462.8 247.4 5.1e-11 42.5 3.9 20.7 20 0 0 20 20 20 19 Calcium-binding EGF domain cEGF PF12662.5 NM_001042545.1_3 - 1e-88 290.6 152.8 1.3e-08 34.5 1.9 21.0 21 0 0 21 21 21 18 Complement Clr-like EGF-like TB PF00683.15 NM_001042545.1_3 - 2.3e-38 129.5 49.2 2.7e-12 46.0 3.9 6.0 5 0 0 5 5 5 4 TB domain EGF PF00008.25 NM_001042545.1_3 - 1.9e-31 107.9 280.4 0.0016 18.5 5.7 22.7 20 1 1 21 21 21 16 EGF-like domain EGF_3 PF12947.5 NM_001042545.1_3 - 5.5e-26 90.3 206.1 4.2e-05 23.5 4.5 21.3 17 1 1 19 19 19 14 EGF domain hEGF PF12661.5 NM_001042545.1_3 - 1.8e-21 75.9 291.0 0.004 17.6 2.7 25.1 26 2 0 26 26 26 15 Human growth factor-like EGF FXa_inhibition PF14670.4 NM_001042545.1_3 - 7e-17 61.3 303.9 0.00038 20.5 7.3 23.0 20 4 3 23 23 23 17 Coagulation Factor Xa inhibitory site EGF_2 PF07974.11 NM_001042545.1_3 - 0.00055 20.1 4.2 0.00055 20.1 4.2 21.5 19 2 1 21 21 21 9 EGF-like domain Mob1_phocein PF03637.15 NM_015387.4_3 - 2.2e-32 112.3 0.7 4e-32 111.5 0.7 1.3 1 0 0 1 1 1 1 Mob1/phocein family Y_phosphatase PF00102.25 NM_080921.3_1 - 1.1e-159 529.0 3.7 1e-81 273.9 0.1 2.5 2 0 0 2 2 2 2 Protein-tyrosine phosphatase CD45 PF12567.6 NM_080921.3_1 - 2.8e-26 91.2 9.8 1e-25 89.4 9.8 2.1 1 0 0 1 1 1 1 Leukocyte receptor CD45 PTP_N PF12453.6 NM_080921.3_1 - 3.1e-16 58.6 2.7 5.7e-16 57.8 2.7 1.5 1 0 0 1 1 1 1 Protein tyrosine phosphatase N terminal fn3 PF00041.19 NM_080921.3_1 - 3.4e-16 59.2 0.0 1.4e-06 28.4 0.0 3.6 3 0 0 3 3 3 2 Fibronectin type III domain Y_phosphatase3 PF13350.4 NM_080921.3_1 - 4.9e-07 29.8 0.0 0.02 14.7 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_080921.3_1 - 2.1e-06 27.9 0.1 0.24 11.4 0.0 4.5 5 0 0 5 5 5 2 Inositol hexakisphosphate DSPc PF00782.18 NM_080921.3_1 - 0.00099 18.8 1.5 0.1 12.3 0.0 3.0 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.11 NM_080921.3_1 - 0.016 14.7 0.0 1.5 8.2 0.0 2.5 2 0 0 2 2 2 0 Tyrosine phosphatase family GnsAB_toxin PF08178.9 NM_080921.3_1 - 0.024 14.4 0.0 0.059 13.2 0.0 1.6 1 0 0 1 1 1 0 GnsA/GnsB toxin of bacterial toxin-antitoxin system SCIMP PF15050.4 NM_080921.3_1 - 0.18 12.1 1.7 1.1 9.6 0.1 2.7 2 0 0 2 2 2 0 SCIMP protein PGC7_Stella PF15549.4 NM_199286.3_1 - 1.2e-34 119.5 0.4 1.6e-34 119.1 0.4 1.1 1 0 0 1 1 1 1 PGC7/Stella/Dppa3 domain CD20 PF04103.13 NM_031457.1_3 - 2e-19 70.1 16.1 4.5e-19 68.9 7.3 2.6 3 0 0 3 3 3 2 CD20-like family Linker_histone PF00538.17 NM_006026.3_1 - 1.7e-17 63.4 0.1 3.6e-17 62.4 0.1 1.5 1 0 0 1 1 1 1 linker histone H1 and H5 family Homeobox_KN PF05920.9 NM_001278682.1_1 - 3e-17 62.1 0.9 5.8e-17 61.2 0.9 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 NM_001278682.1_1 - 2.3e-07 30.4 1.2 4.7e-07 29.4 1.2 1.5 1 0 0 1 1 1 1 Homeobox domain Homez PF11569.6 NM_001278682.1_1 - 0.14 11.5 0.5 0.27 10.6 0.2 1.6 1 1 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez DNA_ligase_A_M PF01068.19 NM_000234.2_1 - 2.1e-68 229.9 0.2 3.1e-68 229.3 0.2 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 NM_000234.2_1 - 1.1e-37 129.8 0.0 2e-37 129.1 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.13 NM_000234.2_1 - 2.4e-24 85.6 0.0 1.3e-23 83.3 0.0 2.4 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.4 NM_000234.2_1 - 0.008 16.1 0.3 2.2 8.3 0.0 2.7 2 0 0 2 2 2 2 DNA ligase OB-like domain RIC3 PF15361.4 NM_001195200.1_1 - 1.1e-05 25.8 0.0 1.8e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 RskA PF10099.7 NM_001195200.1_1 - 0.0063 16.7 2.9 0.0063 16.7 2.9 2.1 1 1 1 2 2 2 1 Anti-sigma-K factor rskA DASH_Hsk3 PF08227.9 NM_001195200.1_1 - 0.038 14.2 6.4 0.078 13.2 6.4 1.5 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like HrpB7 PF09486.8 NM_001195200.1_1 - 0.038 14.3 0.6 0.057 13.7 0.6 1.2 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) IncA PF04156.12 NM_001195200.1_1 - 0.075 12.7 9.6 0.29 10.8 9.6 1.9 1 1 0 1 1 1 0 IncA protein DUF948 PF06103.9 NM_001195200.1_1 - 1.5 9.0 4.1 0.23 11.6 0.3 1.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Arf PF00025.19 NM_001321328.1_3 - 5.7e-32 110.4 0.0 1e-31 109.6 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 NM_001321328.1_3 - 0.00015 21.3 0.0 0.00025 20.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001321328.1_3 - 0.0011 19.1 0.0 0.002 18.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF4414 PF14377.4 NM_001321328.1_3 - 0.09 12.9 4.5 0.22 11.7 4.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4414) Folate_rec PF03024.12 NM_001270444.1_2 - 4e-38 130.8 3.6 5.4e-38 130.4 3.6 1.1 1 0 0 1 1 1 1 Folate receptor family Serglycin PF04360.10 NM_001270444.1_2 - 1.8 8.4 3.8 3.3 7.5 3.8 1.4 1 0 0 1 1 1 0 Serglycin ADH_N_2 PF16884.3 NM_001146155.1_2 - 1.2e-26 92.5 0.0 2e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.24 NM_001146155.1_2 - 3.5e-14 52.7 0.0 6.4e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 NM_001146155.1_2 - 1.3e-10 42.3 0.0 1.9e-10 41.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase zf-H2C2_2 PF13465.4 NM_014803.3_3 - 0.0028 17.9 0.9 0.0028 17.9 0.9 7.8 7 0 0 7 7 7 3 Zinc-finger double domain zf-H2C2_5 PF13909.4 NM_014803.3_3 - 0.0093 15.6 0.6 0.0093 15.6 0.6 5.1 4 0 0 4 4 4 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 NM_014803.3_3 - 0.098 13.0 56.3 0.085 13.2 1.4 8.7 7 0 0 7 7 7 0 Zinc finger, C2H2 type DENN PF02141.19 NM_139157.2_1 - 8.5e-58 195.2 0.5 8.5e-58 195.2 0.5 1.9 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.16 NM_139157.2_1 - 2.1e-17 63.6 0.1 5.2e-17 62.3 0.1 1.7 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 NM_139157.2_1 - 9.5e-13 47.8 3.2 2.6e-12 46.4 3.2 1.8 1 0 0 1 1 1 1 dDENN domain ubiquitin PF00240.21 NM_001304342.1_2 - 1.1e-14 53.8 0.5 1.8e-14 53.1 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.29 NM_001304342.1_2 - 2.7e-06 27.0 0.5 2.7e-06 27.0 0.5 2.0 2 0 0 2 2 2 1 UBA/TS-N domain Rad60-SLD PF11976.6 NM_001304342.1_2 - 0.00039 20.0 0.8 0.00062 19.4 0.8 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.8 NM_001304342.1_2 - 0.0036 17.8 0.0 0.0081 16.7 0.0 1.6 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD HOIP-UBA PF16678.3 NM_001304342.1_2 - 0.04 13.8 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase Rad60-SLD_2 PF13881.4 NM_001304342.1_2 - 0.052 13.5 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 NM_001304342.1_2 - 0.11 12.9 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Arm_2 PF04826.11 NM_001304342.1_2 - 4 6.7 8.7 0.28 10.5 0.3 2.4 3 0 0 3 3 3 0 Armadillo-like Ig_2 PF13895.4 NM_001130167.1_3 - 1.2e-36 124.8 3.2 6.2e-17 61.6 0.2 4.6 4 1 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 NM_001130167.1_3 - 2.6e-33 114.3 7.0 2.1e-08 34.5 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 NM_001130167.1_3 - 1.2e-20 73.2 0.0 0.00032 20.6 0.0 5.4 4 2 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.23 NM_001130167.1_3 - 4.2e-20 71.6 1.0 0.00042 20.3 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 NM_001130167.1_3 - 6.3e-18 64.8 5.3 3.4e-11 43.1 0.0 5.3 3 1 2 5 5 5 2 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_001130167.1_3 - 0.00072 19.8 0.1 0.087 13.1 0.0 3.1 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set PF05790.13 NM_001130167.1_3 - 0.0031 17.5 0.0 6.9 6.8 0.1 4.0 4 0 0 4 4 4 1 Immunoglobulin C2-set domain Lep_receptor_Ig PF06328.9 NM_001130167.1_3 - 0.0047 16.8 0.1 0.93 9.4 0.0 3.1 3 0 0 3 3 3 1 Ig-like C2-type domain Izumo-Ig PF16706.3 NM_001130167.1_3 - 0.0047 16.8 0.0 6.2 6.8 0.0 4.1 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain Acyltransferase PF01553.19 NM_014236.3_3 - 3.4e-25 88.1 0.0 6.5e-25 87.2 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase IncA PF04156.12 NM_001142762.1_2 - 0.34 10.6 2.8 0.49 10.0 2.8 1.2 1 0 0 1 1 1 0 IncA protein ZapB PF06005.10 NM_001142762.1_2 - 2.4 8.5 12.1 59 4.1 12.1 2.4 1 1 0 1 1 1 0 Cell division protein ZapB Pkinase_Tyr PF07714.15 NM_020630.4_2 - 5.7e-101 337.0 0.0 7.5e-101 336.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_020630.4_2 - 2e-43 148.6 0.0 3.5e-43 147.8 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Cadherin PF00028.15 NM_020630.4_2 - 3.6e-17 62.5 0.0 1.4e-10 41.3 0.0 4.4 4 0 0 4 4 4 3 Cadherin domain RIO1 PF01163.20 NM_020630.4_2 - 0.026 14.0 0.0 0.21 11.1 0.0 2.0 2 0 0 2 2 2 0 RIO1 family Pkinase PF00069.23 NM_001288837.1_2 - 8.7e-18 64.5 0.3 1.9e-17 63.4 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001288837.1_2 - 2.4e-10 40.0 0.0 7.5e-10 38.4 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase V-set_CD47 PF08204.9 NM_198793.2_1 - 1e-52 177.4 1.0 1.7e-52 176.7 1.0 1.3 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain CD47 PF04549.12 NM_198793.2_1 - 2.6e-52 176.8 25.3 6.4e-52 175.5 25.3 1.7 1 0 0 1 1 1 1 CD47 transmembrane region Mit_proteolip PF08039.9 NM_198793.2_1 - 0.19 11.9 4.4 0.56 10.4 4.4 1.7 1 0 0 1 1 1 0 Mitochondrial proteolipid 4_1_CTD PF05902.11 NM_001281533.1_1 - 3.1e-35 120.4 9.4 3.1e-35 120.4 9.4 3.2 4 1 1 5 5 5 1 4.1 protein C-terminal domain (CTD) SAB PF04382.11 NM_001281533.1_1 - 3e-24 84.7 2.3 3e-24 84.7 2.3 2.1 2 0 0 2 2 2 1 SAB domain FERM_C PF09380.8 NM_001281533.1_1 - 9.4e-24 83.5 0.0 2.1e-23 82.4 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_001281533.1_1 - 4.9e-21 74.3 0.1 2.3e-20 72.2 0.1 2.1 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.16 NM_001281533.1_1 - 8.1e-20 71.3 0.4 3.9e-19 69.1 0.0 2.3 2 0 0 2 2 2 1 FERM central domain FA PF08736.9 NM_001281533.1_1 - 3.6e-18 65.2 4.4 3.6e-18 65.2 4.4 2.3 2 0 0 2 2 2 1 FERM adjacent (FA) SCAN PF02023.15 NM_033630.2_1 - 1.5e-26 91.9 1.4 2.8e-26 91.1 1.4 1.4 1 0 0 1 1 1 1 SCAN domain SAP30_Sin3_bdg PF13867.4 NM_001131062.1_1 - 1.1e-23 83.1 0.9 1.8e-23 82.5 0.9 1.3 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 zf-SAP30 PF13866.4 NM_001131062.1_1 - 2.7e-18 65.6 0.2 5.7e-18 64.6 0.2 1.5 1 0 0 1 1 1 1 SAP30 zinc-finger LRR_8 PF13855.4 NM_001321679.1_2 - 2.2e-12 46.4 10.1 1.5e-07 30.9 2.9 3.6 1 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 NM_001321679.1_2 - 7.5e-11 41.9 12.5 2.2e-06 27.7 1.0 4.7 3 1 1 5 5 5 3 Leucine Rich repeats (2 copies) Mito_carr PF00153.25 NM_001286807.1_3 - 9.2e-46 153.6 0.1 8.5e-22 76.8 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Reticulon PF02453.15 NM_206901.2_2 - 7.3e-42 142.8 3.8 9e-42 142.5 3.8 1.1 1 0 0 1 1 1 1 Reticulon TANGO2 PF05742.10 NM_152906.6_2 - 2.2e-72 244.0 0.0 2.8e-72 243.7 0.0 1.1 1 0 0 1 1 1 1 Transport and Golgi organisation 2 HSP70 PF00012.18 NM_001318322.1_3 - 0.028 12.5 0.1 1.1 7.3 0.0 2.6 2 1 0 2 2 2 0 Hsp70 protein zf-C2H2 PF00096.24 NM_001308269.1_1 - 0.042 14.2 4.3 0.047 14.0 0.6 3.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001308269.1_1 - 0.11 13.3 1.4 0.5 11.2 0.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger SCP2 PF02036.15 NM_001308269.1_1 - 0.12 12.8 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 SCP-2 sterol transfer family zf-H2C2_2 PF13465.4 NM_001308269.1_3 - 1.7e-74 243.0 78.5 5.6e-09 35.9 0.3 13.1 14 0 0 14 14 14 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001308269.1_3 - 4.9e-56 184.1 77.7 3.1e-07 30.3 0.1 12.8 13 0 0 13 13 12 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001308269.1_3 - 4.5e-33 110.9 74.3 0.00073 20.0 0.1 12.0 13 0 0 13 13 12 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001308269.1_3 - 2.9e-23 81.2 57.8 0.00059 19.6 0.5 10.3 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001308269.1_3 - 2.3e-12 46.7 41.8 0.011 15.8 0.1 9.5 9 0 0 9 9 9 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001308269.1_3 - 6.4e-10 38.9 48.1 0.0075 16.2 1.2 7.3 5 2 3 8 8 7 7 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001308269.1_3 - 1.5e-09 37.3 48.7 0.0047 16.5 0.1 10.0 10 0 0 10 10 10 4 zinc-finger C2H2-type XPA_N PF01286.16 NM_001308269.1_3 - 1.4e-07 31.2 44.7 1.5 8.8 0.1 10.3 11 0 0 11 11 10 4 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001308269.1_3 - 7.8e-07 29.6 37.9 0.0098 16.5 1.5 5.8 1 1 9 10 10 10 8 zinc-ribbon family C1_1 PF00130.20 NM_001308269.1_3 - 0.00031 20.4 34.4 0.49 10.2 1.0 6.9 2 2 5 7 7 7 4 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2HE PF16278.3 NM_001308269.1_3 - 0.00086 19.6 56.0 0.024 15.0 0.3 9.2 3 2 7 10 10 9 3 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.4 NM_001308269.1_3 - 0.005 16.6 25.7 1.1 9.1 1.9 6.7 6 0 0 6 6 6 3 zinc-finger of a C2HC-type zf-trcl PF13451.4 NM_001308269.1_3 - 0.0054 16.5 42.3 5.7 6.8 0.1 10.0 10 1 0 10 10 10 1 Probable zinc-ribbon domain Rpr2 PF04032.14 NM_001308269.1_3 - 0.011 15.9 29.1 1.4 9.2 5.1 4.8 3 3 0 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-met PF12874.5 NM_001308269.1_3 - 0.015 15.6 3.6 0.015 15.6 3.6 9.0 9 0 0 9 9 7 0 Zinc-finger of C2H2 type NifU_N PF01592.14 NM_001308269.1_3 - 0.029 14.4 0.3 4.8 7.2 0.0 3.5 1 1 2 3 3 3 0 NifU-like N terminal domain Zn_Tnp_IS1595 PF12760.5 NM_001308269.1_3 - 0.075 12.9 46.8 5.2 7.0 0.2 8.3 6 2 3 9 9 9 0 Transposase zinc-ribbon domain zf-C2H2_2 PF12756.5 NM_001308269.1_3 - 0.094 12.9 37.5 0.52 10.5 1.9 6.3 1 1 6 7 7 7 0 C2H2 type zinc-finger (2 copies) ADK_lid PF05191.12 NM_001308269.1_3 - 0.1 12.5 33.3 0.36 10.8 2.1 7.0 1 1 8 9 9 9 0 Adenylate kinase, active site lid GATA PF00320.25 NM_001308269.1_3 - 0.24 10.9 24.1 20 4.8 0.2 7.7 7 2 0 7 7 7 0 GATA zinc finger GAGA PF09237.9 NM_001308269.1_3 - 0.39 10.4 3.3 17 5.2 0.3 3.2 3 0 0 3 3 3 0 GAGA factor zf-H2C2_5 PF13909.4 NM_001308269.1_3 - 0.92 9.2 0.0 0.92 9.2 0.0 11.8 13 2 0 13 13 9 0 C2H2-type zinc-finger domain Raffinose_syn PF05691.10 NM_001308269.1_3 - 1.4 6.5 6.3 11 3.5 0.1 3.4 2 2 2 4 4 4 0 Raffinose synthase or seed imbibition protein Sip1 FYVE PF01363.19 NM_001308269.1_3 - 6.3 6.9 43.0 49 4.0 6.9 5.8 2 1 2 4 4 2 0 FYVE zinc finger SDF PF00375.16 NM_001252652.1_2 - 8.2e-131 436.5 29.5 1.1e-130 436.1 29.5 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family OST-HTH PF12872.5 NM_173533.3_3 - 3.9e-31 106.6 1.8 1.6e-09 37.4 0.0 3.5 3 0 0 3 3 3 3 OST-HTH/LOTUS domain TUDOR PF00567.22 NM_173533.3_3 - 1.8e-21 76.3 0.4 4.9e-21 74.9 0.4 1.7 1 0 0 1 1 1 1 Tudor domain BTB PF00651.29 NM_001143823.2_3 - 1.7e-27 95.7 0.7 2.7e-27 95.0 0.7 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 NM_001143823.2_3 - 3.1e-23 80.8 31.5 6e-05 23.1 0.2 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001143823.2_3 - 1.1e-20 72.9 47.9 6.3e-06 26.3 1.7 6.7 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001143823.2_3 - 4.1e-15 55.0 30.9 0.012 16.2 1.1 6.1 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001143823.2_3 - 3.1e-13 49.5 13.9 0.031 14.4 0.0 5.7 5 0 0 5 5 5 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001143823.2_3 - 9.3e-12 44.8 19.7 0.0062 16.8 0.6 5.5 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.4 NM_001143823.2_3 - 0.011 15.5 1.8 0.45 10.3 0.1 2.8 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.3 NM_001143823.2_3 - 2.4 7.8 9.4 5.1 6.8 0.1 4.3 4 0 0 4 4 4 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_001143823.2_3 - 4.4 8.0 11.5 32 5.2 1.6 3.2 1 1 2 3 3 3 0 zinc-ribbon family C1_4 PF07975.10 NM_001143823.2_3 - 7.5 6.8 14.7 20 5.4 1.6 3.8 1 1 1 3 3 3 0 TFIIH C1-like domain LAP1C PF05609.10 NM_015602.3_3 - 1.5e-183 611.0 8.2 1.5e-183 611.0 8.2 2.0 1 1 1 2 2 2 1 Lamina-associated polypeptide 1C (LAP1C) zf-RanBP PF00641.16 NM_004960.3_1 - 4.7e-12 44.9 9.3 1.2e-11 43.5 9.3 1.8 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.20 NM_004960.3_1 - 2.3e-10 40.0 0.0 4.9e-10 39.0 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.30 NM_001260476.1_3 - 5.3e-06 26.9 0.3 0.12 13.2 0.0 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat SCAN PF02023.15 NM_016558.3_2 - 2.8e-26 91.0 1.4 5.3e-26 90.2 1.4 1.4 1 0 0 1 1 1 1 SCAN domain cNMP_binding PF00027.27 NM_001321982.1_3 - 8.1e-41 137.8 0.1 7.9e-21 73.7 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 NM_001321982.1_3 - 1.8e-16 59.3 0.1 3.4e-16 58.5 0.1 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Ion_trans PF00520.29 NM_001194.3_3 - 2e-21 76.2 16.9 2.7e-21 75.8 16.9 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_N PF08412.8 NM_001194.3_3 - 3.5e-20 71.2 0.0 6.6e-20 70.3 0.0 1.5 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.27 NM_001194.3_3 - 6e-18 64.5 0.0 9.9e-18 63.8 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 NM_001194.3_3 - 0.0056 16.5 0.2 0.016 15.0 0.2 1.7 1 0 0 1 1 1 1 Ion channel BLOC1_2 PF10046.7 NM_001282437.1_2 - 2.9e-34 117.1 7.0 3.9e-34 116.7 7.0 1.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 ParB PF08775.8 NM_001282437.1_2 - 0.22 11.9 1.5 0.37 11.1 1.5 1.3 1 0 0 1 1 1 0 ParB family Porphobil_deam PF01379.18 NM_001024382.1_3 - 6e-79 264.2 0.0 7.6e-79 263.9 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.13 NM_001024382.1_3 - 1.1e-21 76.8 0.0 4.2e-21 75.0 0.0 2.0 2 0 0 2 2 2 1 Porphobilinogen deaminase, C-terminal domain C2 PF00168.28 NM_001039112.2_3 - 3.5e-71 235.9 0.0 8.4e-16 58.0 0.0 7.7 6 1 0 6 6 6 6 C2 domain Ferlin_C PF16165.3 NM_001039112.2_3 - 1.4e-38 132.1 6.4 3.1e-37 127.7 0.4 3.8 3 2 2 5 5 5 2 Ferlin C-terminus FerB PF08150.10 NM_001039112.2_3 - 2.9e-29 101.4 0.1 6.8e-29 100.2 0.1 1.7 1 0 0 1 1 1 1 FerB (NUC096) domain FerI PF08151.10 NM_001039112.2_3 - 6.5e-19 67.7 0.1 2e-18 66.1 0.1 1.9 1 0 0 1 1 1 1 FerI (NUC094) domain Synaptobrevin PF00957.19 NM_001039112.2_3 - 9.5 6.0 9.3 20 4.9 9.3 1.5 1 0 0 1 1 1 0 Synaptobrevin GTP_EFTU PF00009.25 NM_021937.4_1 - 4.9e-25 88.1 0.0 7.3e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.23 NM_021937.4_1 - 3.8e-06 27.1 0.0 7.7e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 NM_021937.4_1 - 8e-05 22.6 0.0 0.00017 21.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.17 NM_021937.4_1 - 0.00019 20.9 1.6 0.00025 20.5 0.2 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.8 NM_021937.4_1 - 0.005 16.1 0.7 0.48 9.7 0.7 2.2 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FliS_cochap PF16522.3 NM_021937.4_1 - 0.016 15.0 0.2 0.031 14.1 0.2 1.4 1 0 0 1 1 1 0 Flagellar FLiS export co-chaperone, HP1076 Gtr1_RagA PF04670.10 NM_021937.4_1 - 0.032 13.4 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.7 NM_021937.4_1 - 0.076 12.6 1.2 12 5.4 0.0 2.7 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation RIBIOP_C PF04950.10 NM_021937.4_1 - 0.16 11.3 0.0 0.44 9.8 0.0 1.7 2 0 0 2 2 2 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal GPCR_chapero_1 PF11904.6 NM_033121.1_2 - 8.3e-101 337.3 0.5 1.1e-100 337.0 0.5 1.1 1 0 0 1 1 1 1 GPCR-chaperone Ank_4 PF13637.4 NM_033121.1_2 - 3.1e-10 40.2 0.0 1.2e-09 38.4 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_033121.1_2 - 7e-10 39.2 0.0 1.5e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_033121.1_2 - 2e-07 30.6 0.0 0.0049 17.1 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 NM_033121.1_2 - 9.7e-07 28.9 0.1 4.7e-06 26.7 0.1 2.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.28 NM_033121.1_2 - 9.5e-06 25.7 0.1 0.0038 17.5 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat C1-set PF07654.13 NM_001185113.1_3 - 0.00061 20.1 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Wzy_C PF04932.13 NM_001185113.1_3 - 0.067 12.7 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 O-Antigen ligase Aa_trans PF01490.16 NM_001278387.1_2 - 1.3e-77 261.1 37.9 1.8e-77 260.7 37.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Macro PF01661.19 NM_001033087.1_1 - 1.4e-18 66.9 0.0 3.6e-18 65.6 0.0 1.7 1 0 0 1 1 1 1 Macro domain A_deamin PF02137.16 NM_001111.4_3 - 1.5e-105 353.1 0.0 2.1e-105 352.6 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain z-alpha PF02295.15 NM_001111.4_3 - 2.1e-57 190.9 0.1 2.9e-28 97.6 0.0 2.4 2 0 0 2 2 2 2 Adenosine deaminase z-alpha domain dsrm PF00035.24 NM_001111.4_3 - 1.1e-33 115.5 2.0 2.7e-11 43.9 0.0 3.5 3 0 0 3 3 3 3 Double-stranded RNA binding motif DND1_DSRM PF14709.5 NM_001111.4_3 - 5.3e-05 23.3 0.2 0.91 9.7 0.1 3.6 3 0 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 TrmB PF01978.17 NM_001111.4_3 - 6.4e-05 22.6 0.0 0.0027 17.4 0.0 2.5 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_15 PF12324.6 NM_001111.4_3 - 0.098 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase Dicer_dimer PF03368.12 NM_001111.4_3 - 0.11 12.6 2.9 15 5.7 0.1 3.2 3 0 0 3 3 3 0 Dicer dimerisation domain IL17_R_N PF15037.4 NM_032732.5_3 - 7.8e-158 525.5 10.6 3.3e-156 520.1 10.6 2.1 1 1 0 1 1 1 1 Interleukin-17 receptor extracellular region SEFIR PF08357.9 NM_032732.5_3 - 1.1e-38 132.8 0.0 1.6e-38 132.2 0.0 1.3 1 0 0 1 1 1 1 SEFIR domain Acyl-CoA_dh_N PF02771.14 NM_000159.3_1 - 3.5e-27 95.2 0.0 5.8e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.22 NM_000159.3_1 - 5e-27 94.8 0.4 9.3e-27 93.9 0.4 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.17 NM_000159.3_1 - 3.5e-20 71.9 0.0 6.3e-20 71.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 NM_000159.3_1 - 5.1e-05 23.4 0.0 9.8e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DRMBL PF07522.12 NM_001289076.1_3 - 2.2e-18 66.5 0.2 3.9e-18 65.6 0.2 1.4 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Kelch_1 PF01344.23 NM_198317.2_3 - 2.7e-74 244.4 18.4 4.9e-15 54.7 0.3 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 NM_198317.2_3 - 6e-40 134.1 4.9 1e-06 28.7 0.1 6.5 1 1 5 6 6 6 6 Kelch motif BACK PF07707.13 NM_198317.2_3 - 1.7e-37 127.5 0.1 3.3e-37 126.6 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 NM_198317.2_3 - 4.5e-32 110.4 0.9 9.5e-32 109.4 0.2 1.8 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.4 NM_198317.2_3 - 1.4e-24 85.7 0.9 0.0012 18.6 0.0 6.6 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_198317.2_3 - 9.9e-24 82.2 1.6 0.00019 21.1 0.1 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.4 NM_198317.2_3 - 1.7e-23 82.2 18.3 5e-05 23.3 0.0 6.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_198317.2_3 - 1.9e-06 27.6 5.4 2.6 8.0 0.0 5.2 5 0 0 5 5 5 3 Kelch motif BA14K PF07886.9 NM_198317.2_3 - 0.028 14.2 0.3 0.25 11.1 0.0 2.7 3 0 0 3 3 3 0 BA14K-like protein DUF998 PF06197.11 NM_198317.2_3 - 0.043 13.3 0.2 0.1 12.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF998) RRM_1 PF00076.20 NM_001025076.2_2 - 3.4e-49 164.4 0.0 4.8e-17 61.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 NM_001025076.2_2 - 1.4e-07 31.3 0.0 0.63 10.0 0.0 3.5 3 0 0 3 3 3 3 RNA binding domain RRM_7 PF16367.3 NM_001025076.2_2 - 0.0028 17.6 0.0 1.5 8.8 0.0 3.4 3 0 0 3 3 3 1 RNA recognition motif PHM7_cyt PF14703.4 NM_001025076.2_2 - 0.11 12.6 0.7 4.8 7.2 0.0 2.9 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Pyrid_oxidase_2 PF13883.4 NM_003851.2_1 - 4.8e-57 192.5 0.0 7.5e-57 191.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxidase PF01243.18 NM_003851.2_1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Cyclin_N PF00134.21 NM_001134376.1_3 - 1.5e-18 66.7 0.8 1.5e-18 66.7 0.8 2.4 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 NM_001134376.1_3 - 1.8e-07 31.1 2.1 1.6e-06 28.0 0.2 2.5 2 0 0 2 2 2 1 Cyclin, C-terminal domain Retinal PF15449.4 NM_001029883.2_1 - 0 2141.2 87.7 0 2140.9 87.7 1.1 1 0 0 1 1 1 1 Retinal protein Glyco_transf_7N PF13733.4 NM_001005417.2_1 - 2.9e-55 185.4 0.0 4.4e-55 184.8 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 NM_001005417.2_1 - 5.3e-31 106.0 1.1 9.2e-31 105.2 0.4 1.8 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 NM_001005417.2_1 - 0.017 14.5 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Pkinase PF00069.23 NM_001282394.1_1 - 2.4e-53 181.1 0.0 3.3e-53 180.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001282394.1_1 - 3e-40 138.0 0.0 4.1e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.6 NM_001282394.1_1 - 3.6e-19 68.3 2.1 1.8e-17 62.9 0.1 2.4 2 0 0 2 2 2 2 Oxidative-stress-responsive kinase 1 C terminal Peptidase_M18 PF02127.13 NM_001319119.1_3 - 4.3e-191 635.2 0.0 5.2e-191 635.0 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.12 NM_001319119.1_3 - 5.5e-05 22.2 0.0 0.00018 20.5 0.0 1.7 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase V-set PF07686.15 NM_001173393.2_2 - 1.4e-13 50.8 0.2 3.3e-13 49.6 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 NM_001173393.2_2 - 5.9e-05 23.0 0.7 0.0015 18.5 0.7 2.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_001173393.2_2 - 0.00064 19.6 0.0 0.0018 18.2 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001173393.2_2 - 0.0088 16.2 6.3 0.018 15.2 2.9 2.9 2 1 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 NM_001173393.2_2 - 0.046 14.2 0.9 0.046 14.2 0.9 3.8 3 2 0 3 3 3 0 Immunoglobulin domain Prenyltrans PF00432.19 NM_005023.3_1 - 1.6e-38 130.0 6.3 3.4e-09 36.1 0.0 6.2 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat LRR_6 PF13516.4 NM_001111038.1_2 - 2.7e-21 73.6 16.0 0.05 13.6 0.0 12.2 13 0 0 13 13 13 8 Leucine Rich repeat LRR_4 PF12799.5 NM_001111038.1_2 - 4.8e-11 42.5 33.8 0.015 15.5 0.0 8.9 5 3 4 10 10 10 5 Leucine Rich repeats (2 copies) F-box-like PF12937.5 NM_001111038.1_2 - 0.00016 21.4 0.1 0.00055 19.6 0.1 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_001111038.1_2 - 0.0086 15.8 2.5 0.013 15.3 0.1 2.6 2 0 0 2 2 2 1 F-box domain Ste50p-SAM PF09235.8 NM_001111038.1_2 - 0.082 13.0 4.5 29 4.8 0.0 5.4 7 0 0 7 7 7 0 Ste50p, sterile alpha motif LRR_1 PF00560.31 NM_001111038.1_2 - 0.19 12.2 33.3 21 5.9 1.0 12.1 11 3 2 13 13 13 0 Leucine Rich Repeat LRR_8 PF13855.4 NM_001111038.1_2 - 0.62 9.7 16.2 13 5.5 0.2 6.0 5 2 1 6 6 6 0 Leucine rich repeat Calcipressin PF04847.10 NM_001285393.2_1 - 1.2e-61 207.6 0.9 1.7e-61 207.1 0.9 1.1 1 0 0 1 1 1 1 Calcipressin Ceramidase PF05875.10 NM_001170726.1_2 - 0.8 8.9 5.4 1.3 8.2 5.4 1.4 1 0 0 1 1 1 0 Ceramidase Keratin_B2_2 PF13885.4 NM_030975.2_3 - 3.6e-19 68.3 222.6 1.2e-08 34.6 42.9 5.8 2 1 4 6 6 6 5 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_030975.2_3 - 4.1e-05 23.5 159.5 0.25 11.2 66.5 3.6 1 1 2 3 3 3 3 Keratin, high sulfur B2 protein zf-C3HC4_3 PF13920.4 NM_001323292.1_1 - 1.1e-06 28.3 9.2 1.1e-06 28.3 9.2 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001323292.1_1 - 6.6e-06 25.8 12.5 6.6e-06 25.8 12.5 2.7 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001323292.1_1 - 9.2e-06 25.4 12.0 9.2e-06 25.4 12.0 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_001323292.1_1 - 1.5e-05 24.6 13.5 1.5e-05 24.6 13.5 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001323292.1_1 - 0.00023 21.2 13.0 0.00023 21.2 13.0 4.0 4 0 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.4 NM_001323292.1_1 - 0.0012 18.6 10.6 0.0012 18.6 10.6 2.9 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.4 NM_001323292.1_1 - 0.0046 16.6 14.3 0.0076 16.0 10.0 2.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Ig_2 PF13895.4 NM_001288831.1_3 - 4.3e-20 71.7 0.0 1.9e-10 40.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001288831.1_3 - 1.4e-07 31.9 0.3 0.0028 18.1 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain WD40 PF00400.30 NM_001177591.1_2 - 9e-07 29.4 4.7 9.2 7.2 0.1 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001177591.1_2 - 0.00036 20.7 0.1 0.98 9.6 0.0 3.6 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain SCAN PF02023.15 NM_001023560.3_1 - 2.1e-37 126.7 7.4 4.2e-37 125.7 6.1 2.2 2 0 0 2 2 2 1 SCAN domain zf-H2C2_2 PF13465.4 NM_001023560.3_1 - 1e-34 117.3 74.3 3.7e-08 33.3 0.7 11.1 10 1 0 10 10 10 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001023560.3_1 - 1.4e-32 110.1 70.0 4.9e-05 23.4 0.1 9.3 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001023560.3_1 - 2.3e-16 58.9 68.4 0.0053 17.3 0.1 9.0 9 0 0 9 9 7 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001023560.3_1 - 1.8e-06 27.8 28.5 0.0032 17.4 0.5 5.4 5 0 0 5 5 5 3 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001023560.3_1 - 4.3e-06 26.2 42.6 0.11 12.1 3.2 6.8 6 0 0 6 6 6 5 zinc-finger C2H2-type XPA_N PF01286.16 NM_001023560.3_1 - 2.4e-05 24.1 21.3 0.19 11.7 0.6 7.2 7 0 0 7 7 7 2 XPA protein N-terminal ADK_lid PF05191.12 NM_001023560.3_1 - 0.017 15.0 7.0 13 5.8 0.7 4.7 2 2 3 5 5 5 0 Adenylate kinase, active site lid zf-C2H2_6 PF13912.4 NM_001023560.3_1 - 0.22 11.4 0.1 0.22 11.4 0.1 9.4 9 1 0 9 9 8 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 NM_001023560.3_1 - 0.4 11.3 31.5 0.8 10.4 1.4 4.8 1 1 4 5 5 5 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_001023560.3_1 - 0.9 9.8 24.6 1.3 9.3 0.3 6.2 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding DUF2197 PF09963.7 NM_001023560.3_1 - 3.4 7.9 7.1 0.37 10.9 0.4 2.9 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2197) C1_4 PF07975.10 NM_001023560.3_1 - 8.7 6.6 34.7 3.7 7.8 0.8 5.4 4 1 1 5 5 5 0 TFIIH C1-like domain IF4E PF01652.16 NM_001099408.1_3 - 2.7e-53 179.9 0.3 3.9e-53 179.4 0.3 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Glyco_transf_10 PF00852.17 NM_002033.3_2 - 1.2e-62 210.7 0.0 1.7e-62 210.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 NM_002033.3_2 - 2.2e-37 127.8 0.0 4.5e-37 126.7 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Vinculin PF01044.17 NM_001286974.1_3 - 7.9e-57 193.1 23.6 1.3e-38 132.8 9.4 3.0 3 0 0 3 3 3 3 Vinculin family Focal_AT PF03623.11 NM_001286974.1_3 - 9 6.1 15.7 0.26 11.1 2.6 3.6 3 1 0 3 3 3 0 Focal adhesion targeting region Asp_Glu_race_2 PF14669.4 NM_001145030.1_1 - 2.2e-133 442.6 0.5 3.6e-133 441.9 0.5 1.4 1 0 0 1 1 1 1 Putative aspartate racemase UPF0020 PF01170.16 NM_001321469.1_1 - 4.5e-26 91.6 0.0 1.1e-25 90.4 0.0 1.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.4 NM_001321469.1_1 - 9.7e-10 38.9 0.0 1.9e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001321469.1_1 - 1.6e-09 37.6 1.3 2.3e-09 37.1 0.0 1.9 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001321469.1_1 - 3.6e-08 33.8 0.0 7.7e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain THUMP PF02926.15 NM_001321469.1_1 - 1.3e-07 31.7 1.0 2.5e-07 30.7 1.0 1.4 1 0 0 1 1 1 1 THUMP domain Ubie_methyltran PF01209.16 NM_001321469.1_1 - 2.2e-06 27.1 0.0 3.7e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 NM_001321469.1_1 - 3.1e-06 26.7 0.0 5.4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.10 NM_001321469.1_1 - 0.00067 20.2 0.1 0.0022 18.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.18 NM_001321469.1_1 - 0.0011 18.2 0.0 0.0022 17.2 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase AviRa PF11599.6 NM_001321469.1_1 - 0.023 14.1 0.0 2.6 7.4 0.0 2.3 1 1 1 2 2 2 0 RRNA methyltransferase AviRa Filament PF00038.19 NM_001146226.1_3 - 1.9e-85 287.1 28.8 1.9e-64 218.1 15.1 2.1 1 1 1 2 2 2 2 Intermediate filament protein Keratin_2_head PF16208.3 NM_001146226.1_3 - 3.2e-16 59.8 32.0 1.1e-15 58.1 3.2 3.2 2 1 1 3 3 3 2 Keratin type II head TPR_MLP1_2 PF07926.10 NM_001146226.1_3 - 0.021 14.7 0.1 0.021 14.7 0.1 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.7 NM_001146226.1_3 - 0.078 12.9 18.7 0.033 14.1 5.2 2.7 2 2 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4988 PF16378.3 NM_001146226.1_3 - 0.62 9.5 2.6 8 5.9 0.3 2.7 2 1 2 4 4 4 0 Domain of unknown function DUF5082 PF16888.3 NM_001146226.1_3 - 1.1 9.5 13.8 1.9 8.7 1.5 3.7 2 2 1 3 3 3 0 Domain of unknown function (DUF5082) CLZ PF16526.3 NM_001146226.1_3 - 1.4 9.2 9.3 0.77 10.0 0.9 3.6 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF773 PF05600.10 NM_001278198.1_1 - 3.6e-75 253.5 0.3 4.7e-75 253.1 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF773) DUF773 PF05600.10 NM_001278198.1_2 - 1.1e-37 129.9 0.1 1.4e-37 129.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF773) DUF773 PF05600.10 NM_001278198.1_3 - 3.7e-55 187.5 0.4 4.5e-55 187.2 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF773) 7tm_4 PF13853.4 NM_001004466.1_1 - 4.2e-52 177.5 15.5 5.1e-52 177.2 15.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004466.1_1 - 1.3e-18 67.0 15.1 1.8e-18 66.6 15.1 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001004466.1_1 - 0.00016 21.0 15.2 0.0003 20.1 15.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Sushi PF00084.18 NM_001312672.1_3 - 1.1e-17 64.2 7.9 2.4e-12 47.2 1.7 2.2 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) Sushi_2 PF09014.8 NM_001312672.1_3 - 0.034 14.0 3.7 0.058 13.2 0.3 2.1 1 1 1 2 2 2 0 Beta-2-glycoprotein-1 fifth domain Histone_H2A_C PF16211.3 NM_021065.3_3 - 2e-20 72.1 2.4 3.3e-20 71.4 2.4 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 NM_021065.3_3 - 8.2e-17 61.7 0.0 9.9e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_021065.3_3 - 0.00015 21.8 0.0 0.00021 21.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone eRF1_2 PF03464.13 NM_001291975.1_2 - 9.2e-46 155.3 0.1 1.4e-45 154.7 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.13 NM_001291975.1_2 - 3.6e-38 130.4 0.3 5.6e-38 129.8 0.3 1.3 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.13 NM_001291975.1_2 - 2.6e-17 62.9 0.0 4.3e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 Ribosomal_L7Ae PF01248.24 NM_001291975.1_2 - 0.046 13.3 0.0 0.085 12.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Sushi PF00084.18 NM_000417.2_1 - 3.8e-05 24.1 9.6 0.0081 16.6 1.6 2.6 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) GSH_synth_ATP PF03917.15 NM_000178.3_1 - 1e-129 432.5 0.0 1.3e-129 432.1 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.13 NM_000178.3_1 - 2.8e-33 114.3 0.0 5e-33 113.5 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Kelch_1 PF01344.23 NM_139321.2_1 - 4.7e-25 86.8 6.4 2.6e-05 23.6 0.1 6.7 6 0 0 6 6 6 6 Kelch motif Lectin_C PF00059.19 NM_139321.2_1 - 3e-20 72.8 0.2 3e-20 72.8 0.2 2.4 2 0 0 2 2 1 1 Lectin C-type domain Kelch_6 PF13964.4 NM_139321.2_1 - 1.1e-17 63.4 8.5 4.1e-06 26.8 0.0 6.2 6 0 0 6 6 5 5 Kelch motif PSI PF01437.23 NM_139321.2_1 - 4.4e-15 55.8 53.8 2.1e-12 47.2 11.3 8.2 8 0 0 8 8 5 5 Plexin repeat Kelch_5 PF13854.4 NM_139321.2_1 - 1.1e-13 50.6 21.9 0.00026 20.7 0.1 6.0 6 0 0 6 6 6 4 Kelch motif CUB PF00431.18 NM_139321.2_1 - 6.1e-13 48.9 0.0 1.3e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 CUB domain Kelch_4 PF13418.4 NM_139321.2_1 - 2.8e-12 46.3 8.5 0.25 11.2 0.1 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.4 NM_139321.2_1 - 2.9e-12 46.4 8.7 0.17 12.1 0.0 7.2 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_139321.2_1 - 6e-12 44.9 9.1 0.47 10.4 0.1 6.8 6 0 0 6 6 6 4 Kelch motif Laminin_EGF PF00053.22 NM_139321.2_1 - 0.0032 17.5 16.6 0.0032 17.5 16.6 9.1 7 2 1 8 8 4 3 Laminin EGF domain TMEM100 PF16311.3 NM_139321.2_1 - 0.045 13.2 0.3 0.099 12.1 0.3 1.5 1 0 0 1 1 1 0 Transmembrane protein 100 Reprolysin PF01421.17 NM_003474.5_3 - 1.7e-73 246.7 0.0 3.4e-73 245.7 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_003474.5_3 - 2.2e-32 111.7 3.8 2.2e-32 111.7 3.8 3.2 3 0 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 NM_003474.5_3 - 8.9e-26 90.7 0.0 2e-25 89.5 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_003474.5_3 - 1.7e-21 77.2 0.0 2.9e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 NM_003474.5_3 - 2.7e-19 69.6 29.5 2.7e-19 69.6 29.5 4.0 4 0 0 4 4 4 1 Disintegrin Reprolysin_3 PF13582.4 NM_003474.5_3 - 1.9e-14 54.1 0.0 3e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_003474.5_3 - 8.4e-12 45.3 0.0 1.3e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_003474.5_3 - 1.4e-11 44.3 0.0 2.2e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like BAR PF03114.16 NM_001320640.1_1 - 1.5e-40 139.2 14.4 2.8e-40 138.3 14.4 1.4 1 1 0 1 1 1 1 BAR domain SH3_9 PF14604.4 NM_001320640.1_1 - 9.9e-11 41.2 0.0 9.4e-10 38.1 0.1 2.4 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 NM_001320640.1_1 - 9.5e-07 28.2 0.1 6.3e-06 25.6 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 NM_001320640.1_1 - 1.5e-06 27.7 0.0 4.4e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.6 NM_001320640.1_1 - 0.19 11.3 0.0 0.38 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) BLOC1_2 PF10046.7 NM_001320640.1_1 - 1.2 9.4 7.2 1.3 9.3 4.6 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Apolipoprotein PF01442.16 NM_001320640.1_1 - 8 6.2 12.1 0.64 9.8 2.6 2.5 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain GAGE PF05831.9 NM_001127345.1_1 - 6.5e-37 126.2 12.3 7.5e-37 126.0 12.3 1.0 1 0 0 1 1 1 1 GAGE protein DUF4140 PF13600.4 NM_001114171.1_2 - 0.59 10.5 1.8 1.1 9.6 1.8 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) IncA PF04156.12 NM_001114171.1_2 - 0.8 9.3 2.2 1.6 8.4 2.2 1.4 1 0 0 1 1 1 0 IncA protein DivIC PF04977.13 NM_001114171.1_2 - 1.6 8.4 3.8 2.6 7.7 3.8 1.3 1 0 0 1 1 1 0 Septum formation initiator Clusterin PF01093.15 NM_014410.4_2 - 1e-179 597.9 19.5 1.2e-179 597.7 19.5 1.0 1 0 0 1 1 1 1 Clusterin Cbl_N PF02262.14 NM_014410.4_2 - 0.23 11.4 6.7 11 6.0 1.8 3.3 3 0 0 3 3 3 0 CBL proto-oncogene N-terminal domain 1 ALIX_LYPXL_bnd PF13949.4 NM_014410.4_2 - 0.28 10.3 12.4 0.51 9.4 3.3 3.2 3 0 0 3 3 3 0 ALIX V-shaped domain binding to HIV EF-hand_7 PF13499.4 NM_001284269.1_3 - 1.7e-15 57.1 0.3 4.1e-09 36.7 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_001284269.1_3 - 2.7e-13 48.6 1.0 0.0098 15.6 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.30 NM_001284269.1_3 - 8.7e-12 43.6 1.6 0.00052 19.2 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 NM_001284269.1_3 - 7e-11 41.6 0.9 0.00026 20.6 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 NM_001284269.1_3 - 5.3e-05 22.4 0.1 0.096 12.1 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.4 NM_001284269.1_3 - 0.0024 18.0 0.0 1.3 9.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain RRM_1 PF00076.20 NM_001288727.1_1 - 1.9e-08 33.8 0.0 3.8e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP PF17069.3 NM_001288727.1_1 - 0.00011 21.8 30.2 0.00011 21.8 30.2 2.1 3 0 0 3 3 3 1 Arginine/Serine-Rich protein 1 SR-25 PF10500.7 NM_001288727.1_1 - 0.0058 16.1 22.1 0.0058 16.1 22.1 2.4 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein FAM199X PF15814.3 NM_001288727.1_1 - 0.27 10.1 18.0 0.49 9.3 18.0 1.3 1 0 0 1 1 1 0 Protein family FAM199X Pox_A12 PF04651.11 NM_001288727.1_1 - 0.4 10.6 8.5 0.71 9.8 8.5 1.3 1 0 0 1 1 1 0 Poxvirus A12 protein CCDC106 PF15794.3 NM_001288727.1_1 - 1.2 8.7 11.7 2.7 7.5 11.7 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 NACHT PF05729.10 NM_145007.3_1 - 1.5e-19 70.4 0.0 5.6e-19 68.5 0.0 2.1 1 0 0 1 1 1 1 NACHT domain PYRIN PF02758.14 NM_145007.3_1 - 1.7e-14 53.6 1.3 3.5e-14 52.6 0.5 2.1 2 0 0 2 2 2 1 PAAD/DAPIN/Pyrin domain LRR_6 PF13516.4 NM_145007.3_1 - 3e-06 26.7 33.3 0.0041 16.9 0.1 10.0 10 0 0 10 10 10 2 Leucine Rich repeat Arteri_nucleo PF01481.14 NM_145007.3_1 - 0.26 11.5 1.0 0.37 11.0 0.0 1.8 2 0 0 2 2 2 0 Arterivirus nucleocapsid protein LRR_4 PF12799.5 NM_145007.3_1 - 7.8 6.9 20.9 6.1 7.3 0.0 6.6 5 2 3 8 8 8 0 Leucine Rich repeats (2 copies) S4 PF01479.23 NM_018285.3_3 - 1.4e-08 34.2 0.0 6.3e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.17 NM_018285.3_3 - 4.3e-07 30.7 0.6 6.8e-07 30.0 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Motilin_assoc PF04643.10 NM_016362.4_2 - 9.7e-33 111.7 0.3 1.5e-32 111.1 0.3 1.3 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide Motilin_ghrelin PF04644.10 NM_016362.4_2 - 3.1e-11 42.8 5.1 6.4e-11 41.8 5.1 1.5 1 0 0 1 1 1 1 Motilin/ghrelin 7tm_4 PF13853.4 NM_001004715.1_1 - 1.3e-39 136.5 23.4 1.6e-39 136.2 23.4 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001004715.1_1 - 4.3e-20 71.9 26.0 1.7e-19 70.0 26.0 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001004715.1_1 - 3.4e-08 33.0 25.1 8.7e-08 31.7 25.1 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Methyltransf_4 PF02390.15 NM_005371.5_1 - 3.4e-58 195.8 0.0 4.7e-58 195.3 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.4 NM_005371.5_1 - 0.027 15.0 0.0 0.053 14.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DHR-2 PF06920.11 NM_001318849.1_2 - 2.2e-203 676.6 9.0 2.2e-203 676.6 9.0 1.9 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.4 NM_001318849.1_2 - 3.2e-53 180.3 0.1 7.1e-53 179.2 0.1 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 NM_001318849.1_2 - 6.7e-33 112.8 0.2 1.9e-32 111.3 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.27 NM_001318849.1_2 - 4.9e-13 49.4 0.2 1.4e-12 47.9 0.2 1.9 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 NM_001318849.1_2 - 0.00042 20.5 0.0 0.0014 18.8 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain VPS9 PF02204.16 NM_001319987.1_2 - 1.5e-27 95.7 0.1 1.5e-27 95.7 0.1 1.7 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain T6SS_VipA PF05591.10 NM_001319987.1_2 - 0.1 12.3 0.6 0.2 11.3 0.6 1.4 1 0 0 1 1 1 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 RNA_pol_Rpb4 PF03874.14 NM_001319987.1_2 - 0.11 12.7 0.2 0.24 11.6 0.2 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb4 SH2 PF00017.22 NM_001319987.1_2 - 0.14 12.1 0.8 0.3 11.0 0.1 2.0 2 0 0 2 2 2 0 SH2 domain GLE1 PF07817.11 NM_001499.2_1 - 3.8e-88 294.8 0.1 6.4e-88 294.1 0.1 1.3 1 0 0 1 1 1 1 GLE1-like protein DUF1906 PF08924.9 NM_001499.2_1 - 0.058 13.7 0.3 1.4 9.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1906) TRAPPC9-Trs120 PF08626.9 NM_001321646.1_3 - 1.7e-49 168.0 0.0 1.2e-19 69.2 0.0 5.7 2 1 2 4 4 4 4 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Vps23_core PF09454.8 NM_001321646.1_3 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Vps23 core domain DnaJ_C PF01556.16 NM_001130182.1_1 - 5e-41 140.1 2.6 6.9e-41 139.6 2.6 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 NM_001130182.1_1 - 2.2e-26 91.6 2.1 3.4e-26 91.0 2.1 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.17 NM_001130182.1_1 - 1e-14 54.5 17.4 2e-14 53.6 17.4 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.3 NM_001130182.1_1 - 0.017 15.0 9.8 0.4 10.5 2.2 2.6 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.17 NM_001130182.1_1 - 0.54 10.2 7.0 4.1 7.3 0.3 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_10 PF16685.3 NM_001130182.1_1 - 4.9 7.2 9.9 0.57 10.2 1.0 2.5 1 1 1 2 2 2 0 zinc RING finger of MSL2 WASH_WAHD PF11945.6 NM_001201404.2_3 - 0.053 12.9 0.2 0.053 12.9 0.2 1.3 2 0 0 2 2 2 0 WAHD domain of WASH complex FAM60A PF15396.4 NM_001304951.1_1 - 3.6 7.4 11.5 6.2 6.6 11.5 1.4 1 0 0 1 1 1 0 Protein Family FAM60A IQ PF00612.25 NM_001023571.3_3 - 1.8e-08 33.3 2.9 4.6e-06 25.8 0.1 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif HJURP_C PF12347.6 NM_001023571.3_3 - 0.069 13.0 0.3 0.19 11.6 0.3 1.7 1 0 0 1 1 1 0 Holliday junction regulator protein family C-terminal repeat EF-hand_1 PF00036.30 NM_144647.3_2 - 3.1e-23 79.4 9.7 4.4e-08 32.0 0.6 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 NM_144647.3_2 - 6.1e-23 78.6 6.3 6.2e-07 28.7 0.0 4.5 4 1 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.4 NM_144647.3_2 - 2.1e-21 76.0 7.6 2.9e-10 40.3 3.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_144647.3_2 - 6.4e-15 53.8 8.5 3.3e-05 23.1 0.6 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 NM_144647.3_2 - 2.5e-11 43.1 12.0 8.3e-08 31.8 4.9 4.0 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_144647.3_2 - 0.00081 19.6 0.1 1.1 9.5 0.0 2.6 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_144647.3_2 - 0.0035 17.1 0.6 1.2 9.0 0.1 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.4 NM_144647.3_2 - 1.1 9.5 3.4 2.3 8.5 0.0 3.0 4 1 0 4 4 4 0 EF-hand domain Peptidase_C14 PF00656.20 NM_001223.4_3 - 7.5e-51 173.3 0.0 2e-50 171.9 0.0 1.6 2 0 0 2 2 2 1 Caspase domain CARD PF00619.19 NM_001223.4_3 - 3e-24 84.7 0.1 6.1e-24 83.7 0.1 1.5 1 0 0 1 1 1 1 Caspase recruitment domain IRF PF00605.15 NM_001197124.1_2 - 8.5e-35 119.1 0.0 1.2e-34 118.6 0.0 1.2 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor IRF-3 PF10401.7 NM_001197124.1_2 - 8e-15 55.0 0.0 1.6e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Interferon-regulatory factor 3 UPAR_LY6 PF00021.19 NM_001127223.1_1 - 0.036 14.6 14.0 0.15 12.6 14.0 2.2 1 0 0 1 1 1 0 u-PAR/Ly-6 domain I-set PF07679.14 NM_001290065.1_2 - 1.6e-86 284.4 0.0 5.3e-21 74.4 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001290065.1_2 - 6.5e-81 266.9 1.1 1e-15 57.9 0.0 5.7 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 NM_001290065.1_2 - 7.9e-53 176.6 0.1 7e-10 39.0 0.0 5.7 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 NM_001290065.1_2 - 3.3e-50 168.0 0.0 7.9e-10 38.7 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.15 NM_001290065.1_2 - 3.1e-30 104.4 5.4 3.1e-07 30.4 0.0 8.0 5 4 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001290065.1_2 - 3.7e-10 39.6 1.2 0.019 14.9 0.0 5.4 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain fn3 PF00041.19 NM_001290065.1_2 - 0.011 15.9 0.1 0.023 14.9 0.1 1.5 1 0 0 1 1 1 0 Fibronectin type III domain Adeno_E3_CR1 PF02440.13 NM_001290065.1_2 - 0.034 13.8 0.1 0.66 9.7 0.0 3.1 4 0 0 4 4 4 0 Adenovirus E3 region protein CR1 fn3 PF00041.19 NM_001290065.1_3 - 2.8e-26 91.5 6.1 9.5e-11 41.8 0.1 3.6 3 0 0 3 3 3 3 Fibronectin type III domain Peptidase_C2 PF00648.19 NM_001321270.1_2 - 1.4e-28 99.6 0.0 1.9e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C2 PF00648.19 NM_001321270.1_3 - 3.8e-48 163.9 0.1 5.4e-48 163.4 0.1 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 NM_001321270.1_3 - 2.7e-41 141.0 0.0 4.4e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 NM_001321270.1_3 - 0.00024 20.3 0.0 0.028 13.8 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 NM_001321270.1_3 - 0.00097 18.8 0.0 1.9 8.5 0.0 3.4 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 NM_001321270.1_3 - 0.11 12.9 0.3 4.6 7.6 0.1 2.9 3 0 0 3 3 3 0 EF-hand domain pair Folate_carrier PF01770.16 NM_001319667.1_1 - 1e-88 297.7 22.4 5e-75 252.6 18.9 2.4 1 1 1 2 2 2 2 Reduced folate carrier Pkinase_Tyr PF07714.15 NM_001111032.1_1 - 3.8e-31 108.2 0.1 5.1e-31 107.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001111032.1_1 - 1e-29 103.6 0.0 1.5e-29 103.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 NM_001111032.1_1 - 0.00011 21.4 0.8 0.00021 20.6 0.8 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Spc97_Spc98 PF04130.11 NM_006322.5_2 - 6.4e-120 401.3 6.0 9e-120 400.9 6.0 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family Laminin_G_1 PF00054.21 NM_001289114.1_2 - 1.2e-33 116.0 0.0 2.8e-31 108.3 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_2 PF02210.22 NM_001289114.1_2 - 1.5e-16 61.0 0.0 6e-14 52.6 0.0 2.5 2 1 0 2 2 2 2 Laminin G domain Laminin_G_3 PF13385.4 NM_001289114.1_2 - 0.0064 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1080 PF06439.9 NM_001289114.1_2 - 0.018 15.0 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) RecX PF02631.14 NM_019034.2_1 - 0.17 12.2 0.0 0.28 11.5 0.0 1.2 1 0 0 1 1 1 0 RecX family Ras PF00071.20 NM_019034.2_2 - 3.7e-48 163.1 0.0 4.7e-48 162.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_019034.2_2 - 3.3e-20 72.4 0.0 5.4e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_019034.2_2 - 2.1e-06 27.2 0.0 3.5e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 NM_019034.2_2 - 0.083 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ECR1_N PF14382.4 NM_001282709.1_3 - 2.2e-15 56.0 0.7 3.7e-15 55.3 0.7 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.3 NM_001282709.1_3 - 3.4e-13 49.6 0.0 6.6e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 KH domain Rif1_N PF12231.6 NM_001177665.1_2 - 1.3e-77 261.2 2.8 1.3e-77 261.2 2.8 2.1 3 0 0 3 3 3 1 Rap1-interacting factor 1 N terminal NICE-1 PF15845.3 NM_001177665.1_2 - 0.085 13.5 4.0 0.28 11.8 4.0 1.8 1 0 0 1 1 1 0 Cysteine-rich C-terminal 1 family Thg1C PF14413.4 NM_001317825.1_1 - 2.9e-47 159.7 0.0 4.5e-47 159.1 0.0 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain Thg1 PF04446.10 NM_001317825.1_1 - 3.5e-05 23.7 0.0 5.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1 PF04446.10 NM_001317825.1_2 - 4.9e-36 123.4 0.3 7.4e-36 122.8 0.3 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Pkinase PF00069.23 NM_001135740.1_1 - 1.4e-74 250.7 0.0 1.7e-74 250.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001135740.1_1 - 1.8e-34 119.1 0.0 2.2e-34 118.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001135740.1_1 - 2.6e-06 26.9 0.0 3.5e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001135740.1_1 - 0.0015 17.8 0.0 0.0025 17.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001135740.1_1 - 0.039 13.7 0.1 1.4 8.7 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.20 NM_001135740.1_1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 RIO1 family LNP1 PF15419.4 NM_001135740.1_3 - 0.21 11.7 0.5 0.43 10.6 0.5 1.4 1 0 0 1 1 1 0 Leukemia NUP98 fusion partner 1 VPS9 PF02204.16 NM_001195833.1_1 - 1e-18 67.3 0.0 1.8e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Defensin_beta_2 PF13841.4 NM_152251.3_3 - 1.3e-05 25.5 12.4 1.3e-05 25.5 12.4 1.7 2 0 0 2 2 2 1 Beta defensin CABIT PF12736.5 NM_004848.3_3 - 1.8e-13 50.3 0.3 3.5e-13 49.4 0.3 1.4 1 1 0 1 1 1 1 Cell-cycle sustaining, positive selection, RCC1 PF00415.16 NM_148842.2_1 - 1.2e-47 160.2 20.0 9.2e-08 32.5 0.2 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 NM_148842.2_1 - 2.5e-23 81.2 33.4 3.9e-09 36.0 1.7 6.8 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat DUF4224 PF13986.4 NM_148842.2_2 - 0.076 12.8 0.1 0.19 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4224) Guanylate_kin PF00625.19 NM_001242840.1_1 - 8.5e-60 201.4 0.0 1.1e-59 201.0 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.4 NM_001242840.1_1 - 1.6e-06 28.2 0.3 1.8e-05 24.8 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.4 NM_001242840.1_1 - 4.6e-06 27.0 0.0 9e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 NM_001242840.1_1 - 1.4e-05 25.4 0.1 6.3e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.25 NM_001242840.1_1 - 0.00064 20.1 0.2 0.00097 19.5 0.2 1.5 1 1 0 1 1 1 1 ABC transporter DUF258 PF03193.14 NM_001242840.1_1 - 0.00067 19.5 0.1 0.0012 18.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.4 NM_001242840.1_1 - 0.00072 19.7 0.1 0.0019 18.4 0.0 1.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.21 NM_001242840.1_1 - 0.00094 19.1 0.0 0.0016 18.3 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.4 NM_001242840.1_1 - 0.0052 16.3 0.1 0.0092 15.6 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain cobW PF02492.17 NM_001242840.1_1 - 0.0056 16.1 0.1 0.012 15.1 0.1 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.10 NM_001242840.1_1 - 0.0084 15.9 0.2 0.017 14.9 0.0 1.5 2 0 0 2 2 1 1 NACHT domain Cnn_1N PF07989.9 NM_001242840.1_1 - 0.0093 15.9 0.6 0.016 15.2 0.6 1.3 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 AAA_28 PF13521.4 NM_001242840.1_1 - 0.0098 16.0 0.3 0.021 14.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 NM_001242840.1_1 - 0.01 15.4 0.3 0.12 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 NM_001242840.1_1 - 0.023 13.8 0.1 0.049 12.8 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.20 NM_001242840.1_1 - 0.032 14.5 0.0 0.05 13.9 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.4 NM_001242840.1_1 - 0.032 14.1 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.13 NM_001242840.1_1 - 0.033 14.0 0.0 0.049 13.4 0.0 1.3 1 0 0 1 1 1 0 NTPase dNK PF01712.17 NM_001242840.1_1 - 0.039 13.7 0.2 0.81 9.4 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase DUF2075 PF09848.7 NM_001242840.1_1 - 0.063 12.4 0.3 0.97 8.5 0.3 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.12 NM_001242840.1_1 - 0.066 13.1 0.3 0.44 10.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.27 NM_001242840.1_1 - 0.1 12.9 0.0 0.23 11.7 0.0 1.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.15 NM_001242840.1_1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Dynamin_N PF00350.21 NM_001242840.1_1 - 0.14 12.1 0.1 0.26 11.2 0.0 1.5 2 0 0 2 2 2 0 Dynamin family Rad17 PF03215.13 NM_001242840.1_1 - 0.17 10.6 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Roc PF08477.11 NM_001242840.1_1 - 0.19 11.9 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.16 NM_001242840.1_1 - 0.22 11.3 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Requiem_N PF14051.4 NM_001280542.1_2 - 2e-37 127.1 0.4 5.1e-37 125.8 0.4 1.7 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. PHD PF00628.27 NM_001280542.1_2 - 5.2e-22 77.3 22.8 1.5e-11 43.9 5.5 3.4 2 1 1 3 3 3 2 PHD-finger PHD_4 PF16866.3 NM_001280542.1_2 - 0.0057 16.6 6.4 0.0057 16.6 6.4 3.8 2 1 1 3 3 3 1 PHD-finger Lar_restr_allev PF14354.4 NM_001280542.1_2 - 0.015 15.5 1.5 0.015 15.5 1.5 4.1 2 1 1 3 3 2 0 Restriction alleviation protein Lar zf-C2H2 PF00096.24 NM_001280542.1_2 - 0.027 14.8 1.4 0.027 14.8 1.4 4.3 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001280542.1_2 - 0.035 14.8 0.8 0.035 14.8 0.8 4.6 6 1 0 6 6 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_001280542.1_2 - 0.2 12.1 0.1 0.2 12.1 0.1 5.0 6 0 0 6 6 6 0 Zinc-finger double domain zf-RING_7 PF02591.13 NM_001280542.1_2 - 0.5 10.5 4.9 7.6 6.7 0.1 3.5 3 0 0 3 3 3 0 C4-type zinc ribbon domain C1_1 PF00130.20 NM_001280542.1_2 - 0.61 9.9 22.1 1.3 8.8 5.7 4.3 4 0 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.4 NM_001280542.1_2 - 0.72 9.3 14.2 0.28 10.7 2.0 3.2 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain zf-BED PF02892.13 NM_001280542.1_2 - 1.3 9.0 7.3 1.1 9.2 0.0 3.5 3 0 0 3 3 3 0 BED zinc finger PHD_2 PF13831.4 NM_001280542.1_2 - 2.1 7.8 21.6 0.043 13.2 2.2 4.0 4 0 0 4 4 4 0 PHD-finger Prok-RING_1 PF14446.4 NM_001280542.1_2 - 5.7 6.8 24.0 1.3 8.8 1.6 3.9 3 1 1 4 4 4 0 Prokaryotic RING finger family 1 TPT PF03151.14 NM_001199787.1_2 - 4.4e-30 104.9 3.4 5.7e-30 104.5 3.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 NM_001199787.1_2 - 0.00028 21.0 8.4 0.00056 20.0 7.7 1.7 2 0 0 2 2 2 1 EamA-like transporter family TPT PF03151.14 NM_001199787.1_3 - 3.6e-07 29.7 0.0 5.4e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family RRM_1 PF00076.20 NM_001294348.1_2 - 8.5e-64 211.2 0.1 2.7e-20 71.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001294348.1_2 - 3.3e-12 46.0 0.0 0.00012 21.5 0.0 3.4 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_001294348.1_2 - 0.06 13.1 0.0 7.7 6.3 0.0 3.0 3 0 0 3 3 3 0 Occluded RNA-recognition motif S_100 PF01023.17 NM_001024212.1_3 - 1.4e-14 53.4 0.2 2.5e-14 52.6 0.2 1.5 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain Ig_2 PF13895.4 NM_133269.3_3 - 1.7e-09 37.8 0.0 0.0003 20.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_133269.3_3 - 9.1e-07 29.3 0.0 0.0041 17.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_133269.3_3 - 2e-05 24.5 0.0 0.18 11.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain BEX PF04538.10 NM_001006937.2_2 - 1.9e-41 141.4 47.9 1.2e-37 129.2 41.7 3.5 2 1 0 2 2 2 1 Brain expressed X-linked like family Calcipressin PF04847.10 NM_005822.3_3 - 7.8e-64 214.7 0.3 1.1e-63 214.3 0.3 1.1 1 0 0 1 1 1 1 Calcipressin RRM_1 PF00076.20 NM_005822.3_3 - 0.1 12.3 0.4 0.17 11.6 0.4 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GTP_EFTU PF00009.25 NM_006620.3_1 - 1.8e-46 158.0 0.0 2.7e-46 157.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 NM_006620.3_1 - 7.8e-30 103.3 0.1 1.6e-29 102.3 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain HBS1_N PF08938.8 NM_006620.3_1 - 1.5e-17 63.5 0.3 3e-17 62.6 0.3 1.4 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D2 PF03144.23 NM_006620.3_1 - 1.8e-07 31.3 0.3 3.9e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 NM_006620.3_1 - 0.00011 22.1 0.1 0.0023 17.9 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase zf-MYND PF01753.16 NM_001146192.1_1 - 1.7e-08 34.2 7.3 3.6e-08 33.2 7.3 1.6 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.4 NM_001146192.1_1 - 4 7.5 5.9 4.8 7.2 4.8 1.6 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 TPR_12 PF13424.4 NM_001146192.1_3 - 4.7e-05 23.5 11.5 0.23 11.7 0.1 4.2 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001146192.1_3 - 0.00038 20.3 4.6 0.41 10.8 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001146192.1_3 - 0.0017 18.2 10.0 0.021 14.8 0.9 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001146192.1_3 - 0.014 15.1 12.6 0.19 11.5 0.5 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001146192.1_3 - 0.16 12.5 0.3 74 4.2 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001146192.1_3 - 0.19 12.1 1.8 1.2 9.6 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001146192.1_3 - 0.77 9.6 3.6 13 5.7 0.4 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-H2C2_2 PF13465.4 NM_001278510.2_3 - 5e-118 380.6 133.1 5.8e-08 32.7 0.5 20.0 19 0 0 19 19 19 18 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001278510.2_3 - 4.3e-77 250.4 151.1 5.3e-06 26.5 0.2 19.3 19 0 0 19 19 19 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001278510.2_3 - 1.4e-41 137.4 137.4 0.014 16.0 0.2 18.5 18 0 0 18 18 18 17 C2H2-type zinc finger KRAB PF01352.25 NM_001278510.2_3 - 4.7e-20 70.9 0.7 8.3e-20 70.1 0.7 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001278510.2_3 - 6.3e-15 54.6 114.4 0.00024 20.9 0.6 17.4 17 0 0 17 17 17 13 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001278510.2_3 - 1.6e-05 24.8 92.8 0.046 13.7 1.9 11.4 4 2 8 14 14 14 10 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001278510.2_3 - 4.7e-05 23.4 61.9 2.5 8.4 0.1 16.4 17 0 0 17 17 17 3 Zinc-finger double-stranded RNA-binding Fumble PF03630.12 NM_018216.2_3 - 2.5e-131 437.7 0.4 3.1e-131 437.4 0.4 1.1 1 0 0 1 1 1 1 Fumble DUF89 PF01937.17 NM_018216.2_3 - 4.2e-56 190.4 0.0 6e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF89 DBR1 PF05011.11 NM_016216.3_2 - 8e-35 120.1 0.0 1.3e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.26 NM_016216.3_2 - 4.4e-10 40.3 0.2 3.5e-09 37.3 0.1 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 NM_016216.3_2 - 0.041 14.0 0.0 0.11 12.6 0.0 1.7 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain HLH PF00010.24 NM_001276373.1_1 - 8e-18 64.0 0.2 1.3e-17 63.3 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Rootletin PF15035.4 NM_001276373.1_1 - 0.011 15.7 4.3 0.018 15.0 4.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion HALZ PF02183.16 NM_001276373.1_1 - 4.1 7.6 8.5 1.7 8.8 2.1 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper Annexin PF00191.18 NM_001320702.1_2 - 1.1e-96 316.7 9.1 4.1e-25 87.5 0.1 4.2 4 0 0 4 4 4 4 Annexin adh_short PF00106.23 NM_198708.2_2 - 8.5e-18 64.4 0.0 1.3e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_198708.2_2 - 1.8e-07 30.8 0.0 2.7e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.8 NM_198708.2_2 - 0.042 13.1 0.0 0.06 12.6 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) adh_short PF00106.23 NM_198708.2_3 - 0.0013 18.1 0.1 0.0017 17.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Myb_DNA-bind_4 PF13837.4 NM_001012981.4_3 - 6.9e-38 128.8 1.0 4.5e-18 65.3 0.2 2.5 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain SCAN PF02023.15 NM_001012981.4_3 - 2.3e-37 126.6 3.1 6.2e-37 125.2 3.1 1.7 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 NM_001012981.4_3 - 5.6e-36 121.2 51.8 1.4e-07 31.5 0.2 8.1 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001012981.4_3 - 2e-27 93.9 51.8 5.4e-06 26.4 1.9 7.7 7 0 0 7 7 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001012981.4_3 - 5.3e-12 45.3 51.1 0.039 14.6 1.9 8.8 8 0 0 8 8 7 6 C2H2-type zinc finger KRAB PF01352.25 NM_001012981.4_3 - 1.4e-05 24.5 0.0 3.5e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 KRAB box Myb_DNA-bind_3 PF12776.5 NM_001012981.4_3 - 3e-05 24.6 2.4 0.21 12.3 0.2 2.6 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 NM_001012981.4_3 - 0.00091 19.4 0.7 0.67 10.2 0.1 2.9 2 0 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like zf-C2H2_11 PF16622.3 NM_001012981.4_3 - 0.00099 18.7 29.7 0.12 12.0 1.2 6.3 6 0 0 6 6 6 4 zinc-finger C2H2-type Myb_DNA-bind_6 PF13921.4 NM_001012981.4_3 - 0.003 17.6 1.2 2.3 8.4 0.1 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.29 NM_001012981.4_3 - 0.0099 15.9 1.1 2.8 8.0 0.1 3.2 2 2 0 2 2 2 1 Myb-like DNA-binding domain zf-C2H2_jaz PF12171.6 NM_001012981.4_3 - 0.023 14.9 20.6 0.61 10.3 0.1 6.2 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.9 NM_001012981.4_3 - 0.13 12.0 25.2 0.41 10.5 0.6 5.5 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger OSTMP1 PF09777.7 NM_001012981.4_3 - 0.19 10.9 11.6 9.3 5.4 0.0 3.5 3 0 0 3 3 3 0 Osteopetrosis-associated transmembrane protein 1 precursor KRTDAP PF15200.4 NM_001190347.1_1 - 0.0016 18.0 7.3 0.15 11.7 2.0 2.3 1 1 1 2 2 2 2 Keratinocyte differentiation-associated zf-C4 PF00105.16 NM_001489.4_3 - 1.6e-27 95.6 18.1 1.6e-27 95.6 18.1 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001489.4_3 - 2.8e-18 66.2 4.1 4.6e-18 65.4 4.1 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Ank_2 PF12796.5 NM_001145210.2_1 - 7.3e-51 170.6 0.2 6.8e-16 58.5 0.0 4.6 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001145210.2_1 - 1.4e-45 153.0 18.1 4.5e-12 46.1 0.1 6.3 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001145210.2_1 - 3.7e-37 122.0 13.9 8.9e-05 22.5 0.0 9.4 8 1 1 9 9 9 9 Ankyrin repeat Ank PF00023.28 NM_001145210.2_1 - 1.3e-35 120.1 27.7 2.2e-05 24.6 0.1 9.7 9 1 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.4 NM_001145210.2_1 - 3.8e-34 116.1 26.7 9.1e-09 35.3 0.2 7.6 2 2 7 9 9 9 9 Ankyrin repeats (many copies) TPR_14 PF13428.4 NM_001033505.1_2 - 0.0049 17.4 0.0 0.018 15.7 0.0 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001033505.1_2 - 0.013 16.0 1.0 0.017 15.6 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat NRDE-2 PF08424.8 NM_001033505.1_2 - 0.024 13.6 0.4 1.9 7.4 0.1 2.0 1 1 1 2 2 2 0 NRDE-2, necessary for RNA interference ArfGap PF01412.16 NM_001284308.1_1 - 7.9e-27 93.5 0.0 1.4e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.27 NM_001284308.1_1 - 3.7e-22 78.7 0.0 1.8e-12 47.6 0.0 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.4 NM_001284308.1_1 - 3e-06 27.5 1.4 0.0034 17.7 0.2 3.6 2 2 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.4 NM_001284308.1_1 - 1.1e-05 25.5 0.4 0.14 12.3 0.0 3.2 3 0 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.4 NM_001284308.1_1 - 0.0071 16.3 0.1 0.45 10.5 0.0 2.6 3 0 0 3 3 3 1 PH domain zf-A20 PF01754.14 NM_001242919.1_1 - 2.4e-12 46.4 8.8 7.5e-12 44.8 8.8 2.0 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.14 NM_001242919.1_1 - 5.6e-09 35.9 7.7 5.6e-09 35.9 7.7 2.8 2 0 0 2 2 2 1 AN1-like Zinc finger 2-Hacid_dh_C PF02826.17 NM_001321014.1_3 - 1.4e-54 184.0 0.0 2e-54 183.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 NM_001321014.1_3 - 1.7e-28 98.8 0.0 2.2e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 NM_001321014.1_3 - 0.0022 18.0 0.0 0.0036 17.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NADH_dh_m_C1 PF15088.4 NM_002494.3_2 - 2.9e-32 109.9 0.2 4.7e-32 109.2 0.2 1.3 1 0 0 1 1 1 1 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial WAP PF00095.19 NM_006103.3_2 - 1.7e-20 73.0 36.7 1.4e-11 44.5 15.0 2.3 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' OAD_gamma PF04277.11 NM_017409.3_2 - 1.7 9.1 3.7 2.9 8.4 2.0 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Homeobox PF00046.27 NM_017409.3_3 - 2.3e-20 72.0 6.2 5.1e-20 70.9 6.2 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_017409.3_3 - 0.023 14.5 0.7 0.08 12.7 0.7 2.0 1 0 0 1 1 1 0 Homeobox KN domain EABR PF12180.6 NM_001127182.1_3 - 2e-18 65.6 2.3 4.8e-18 64.3 2.3 1.7 1 0 0 1 1 1 1 TSG101 and ALIX binding domain of CEP55 zf-C2H2_3 PF13878.4 NM_001127182.1_3 - 0.0087 15.7 0.2 0.018 14.7 0.2 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Cep57_CLD_2 PF14197.4 NM_001127182.1_3 - 0.013 15.4 7.1 0.013 15.4 7.1 4.8 3 2 1 4 4 4 0 Centrosome localisation domain of PPC89 CENP-F_leu_zip PF10473.7 NM_001127182.1_3 - 3.8 7.4 68.7 0.46 10.4 8.5 4.4 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SAM_1 PF00536.28 NM_001010971.2_1 - 1.4e-08 34.9 0.0 3.6e-08 33.6 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001010971.2_1 - 4.5e-05 23.3 0.0 0.00017 21.5 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_001010971.2_1 - 0.0012 18.7 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain EAF PF09816.7 NM_033083.6_2 - 2.7e-22 78.9 0.0 4.6e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor AF-4 PF05110.11 NM_033083.6_2 - 9.7 4.0 26.0 16 3.3 26.0 1.3 1 1 0 1 1 1 0 AF-4 proto-oncoprotein TPR_1 PF00515.26 NM_001114091.2_3 - 7.5e-44 145.7 10.9 3e-09 36.2 0.2 9.3 9 0 0 9 9 9 7 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001114091.2_3 - 4e-31 106.9 23.5 7.4e-23 80.4 5.4 5.6 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.15 NM_001114091.2_3 - 1.4e-29 99.6 12.3 1.6e-05 24.5 0.1 9.4 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001114091.2_3 - 5.9e-24 82.1 9.0 0.00037 20.4 0.2 8.9 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001114091.2_3 - 2.2e-23 82.2 3.5 1.1e-05 25.5 0.0 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001114091.2_3 - 4.7e-23 80.5 7.8 2.3e-06 27.1 0.1 7.9 3 2 6 9 9 9 5 TPR repeat TPR_17 PF13431.4 NM_001114091.2_3 - 2.6e-19 68.0 7.1 0.0085 16.3 0.0 9.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001114091.2_3 - 1.9e-17 63.5 0.0 8e-08 32.7 0.0 5.7 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001114091.2_3 - 2e-16 60.1 3.4 0.098 13.1 0.0 7.3 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001114091.2_3 - 9.4e-14 50.8 0.0 0.017 15.8 0.0 7.7 4 1 4 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001114091.2_3 - 1.3e-10 41.2 0.0 0.00014 21.8 0.0 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001114091.2_3 - 9e-10 38.4 8.2 0.41 11.3 0.0 7.9 8 0 0 8 8 8 2 Tetratricopeptide repeat ChAPs PF09295.8 NM_001114091.2_3 - 3.9e-05 22.7 1.0 0.0078 15.1 0.0 2.2 1 1 1 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.4 NM_001114091.2_3 - 4.1e-05 23.2 1.6 11 6.2 0.0 6.6 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_15 PF13429.4 NM_001114091.2_3 - 0.0024 17.0 0.1 2.7 7.0 0.0 3.9 2 1 1 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001114091.2_3 - 0.031 14.0 0.0 4.2 7.3 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat wnt PF00110.17 NM_001300939.1_3 - 6.9e-93 311.4 24.9 9.2e-93 311.0 24.9 1.1 1 0 0 1 1 1 1 wnt family LRRFIP PF09738.7 NM_017724.2_1 - 7.7e-108 360.4 24.9 7.7e-108 360.4 24.9 2.0 2 0 0 2 2 2 1 LRRFIP family Reo_sigmaC PF04582.10 NM_017724.2_1 - 0.17 11.1 5.6 5 6.3 0.3 2.8 2 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF1664 PF07889.10 NM_017724.2_1 - 0.24 11.2 26.2 1.7 8.5 2.7 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.10 NM_017724.2_1 - 0.36 11.2 9.0 0.15 12.4 0.8 3.1 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein AAA_13 PF13166.4 NM_017724.2_1 - 2.3 6.6 28.9 0.05 12.1 6.7 2.6 3 0 0 3 3 3 0 AAA domain DUF724 PF05266.12 NM_017724.2_1 - 4 7.1 41.1 0.029 14.1 7.9 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.17 NM_017724.2_1 - 5.6 4.6 20.4 2.1 6.0 6.3 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family zf-met PF12874.5 NM_001308215.1_3 - 2.1e-16 59.6 16.2 3.1e-07 30.4 0.5 4.0 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001308215.1_3 - 1.6e-09 37.6 14.0 0.0088 16.2 0.4 4.6 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.10 NM_001308215.1_3 - 0.077 12.6 7.4 5.6 6.7 1.2 3.4 3 0 0 3 3 3 0 U1 zinc finger zf-C2H2_2 PF12756.5 NM_001308215.1_3 - 4.8 7.4 20.3 4.6 7.5 0.3 4.1 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) ACAS_N PF16177.3 NM_001199172.1_2 - 0.063 13.1 0.4 0.11 12.3 0.4 1.3 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus Glyco_transf_18 PF15024.4 NM_001199172.1_3 - 9.9e-265 879.3 0.0 1.2e-264 879.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 MRP-L28 PF09812.7 NM_001318152.1_1 - 7e-61 204.9 13.3 9.7e-61 204.5 13.3 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Toxin_18 PF08087.9 NM_001318152.1_2 - 0.052 13.4 2.1 0.16 11.8 2.1 1.9 1 0 0 1 1 1 0 Conotoxin O-superfamily AMP-binding PF00501.26 NM_001252677.1_3 - 2.2e-89 299.8 0.1 2.8e-89 299.5 0.1 1.0 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.3 NM_001252677.1_3 - 6.8e-14 51.4 0.1 1.2e-13 50.6 0.1 1.4 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus ACBP PF00887.17 NM_001178041.2_3 - 5.7e-32 109.7 0.9 9e-32 109.0 0.9 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein Insulin PF00049.16 NM_001042376.2_3 - 1.3e-10 42.0 0.1 1.7e-10 41.6 0.1 1.4 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family RRM_1 PF00076.20 NM_001177711.1_2 - 3.7e-30 103.4 0.0 1.8e-15 56.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ald_Xan_dh_C2 PF02738.16 NM_000379.3_2 - 1e-209 697.4 0.0 1.3e-209 697.1 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 NM_000379.3_2 - 2.1e-47 160.9 0.0 3.7e-47 160.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 NM_000379.3_2 - 1.6e-35 121.6 0.1 3e-35 120.8 0.1 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 NM_000379.3_2 - 3e-31 107.0 0.2 6.8e-31 105.9 0.2 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 NM_000379.3_2 - 5.6e-25 87.4 0.0 2.1e-24 85.5 0.0 2.0 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 NM_000379.3_2 - 1.2e-08 34.7 0.2 1.2e-08 34.7 0.2 2.8 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain Abhydrolase_1 PF00561.18 NM_020676.6_3 - 1.2e-24 87.2 0.0 2.2e-24 86.3 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_020676.6_3 - 6.4e-18 66.0 0.0 1.4e-17 65.0 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 NM_020676.6_3 - 1.1e-15 57.5 0.0 2.2e-15 56.4 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 NM_020676.6_3 - 1.7e-05 23.5 0.1 5.2e-05 21.9 0.1 1.6 1 1 0 1 1 1 1 Ndr family BAAT_C PF08840.9 NM_020676.6_3 - 0.0095 15.7 0.0 0.037 13.8 0.0 1.8 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1057 PF06342.10 NM_020676.6_3 - 0.011 14.7 0.0 0.016 14.1 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) FSH1 PF03959.11 NM_020676.6_3 - 0.016 14.8 0.1 0.99 8.9 0.0 2.4 2 1 0 2 2 2 0 Serine hydrolase (FSH1) DLH PF01738.16 NM_020676.6_3 - 0.023 14.1 0.0 0.39 10.1 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family MANEC PF07502.12 NM_001146221.1_1 - 3.5e-08 33.5 2.0 8.5e-08 32.2 2.0 1.6 1 0 0 1 1 1 1 MANEC domain TBCC_N PF16752.3 NM_001146221.1_1 - 0.012 15.9 0.0 0.021 15.1 0.0 1.4 1 0 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain p450 PF00067.20 NM_000774.4_1 - 4.6e-150 500.3 0.0 5.3e-150 500.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4131 PF13567.4 NM_000774.4_1 - 0.2 11.1 1.0 3.3 7.2 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Homeobox PF00046.27 NM_001029865.2_1 - 3.3e-21 74.7 3.5 6.7e-21 73.7 3.5 1.5 1 0 0 1 1 1 1 Homeobox domain DUF2986 PF11661.6 NM_001029865.2_1 - 0.014 15.8 1.4 0.014 15.8 1.4 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2986) Homeobox_KN PF05920.9 NM_001029865.2_1 - 0.016 15.0 0.1 0.033 14.0 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain RGS12_us1 PF16613.3 NM_198229.2_2 - 1.1e-58 196.5 11.4 1.1e-58 196.5 11.4 2.9 3 0 0 3 3 2 1 Unstructured region of RGS12 RGS12_usC PF16612.3 NM_198229.2_2 - 3.2e-56 189.6 15.2 3.2e-56 189.6 15.2 2.4 3 0 0 3 3 2 1 C-terminal unstructured region of RGS12 RGS12_us2 PF16611.3 NM_198229.2_2 - 3.1e-34 117.1 10.6 3.1e-34 117.1 10.6 2.3 2 0 0 2 2 2 1 Unstructured region between RBD and GoLoco RBD PF02196.13 NM_198229.2_2 - 1.2e-32 111.6 0.0 3.4e-19 68.6 0.0 2.6 2 0 0 2 2 2 2 Raf-like Ras-binding domain RGS PF00615.17 NM_198229.2_2 - 2.6e-27 95.3 2.7 4.2e-27 94.6 2.7 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain PDZ PF00595.22 NM_198229.2_2 - 5.2e-13 49.0 0.0 1.4e-12 47.6 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) GoLoco PF02188.15 NM_198229.2_2 - 6.9e-09 34.9 0.3 1.5e-08 33.8 0.3 1.6 1 0 0 1 1 1 1 GoLoco motif PID PF00640.21 NM_198229.2_2 - 0.00065 19.6 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ_2 PF13180.4 NM_198229.2_2 - 0.0031 17.7 0.0 0.0085 16.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain TUG-UBL1 PF11470.6 NM_198229.2_2 - 0.007 16.5 0.0 0.34 11.1 0.0 2.7 2 0 0 2 2 2 1 TUG ubiquitin-like domain PT-HINT PF07591.9 NM_198229.2_2 - 0.07 13.2 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Pretoxin HINT domain Pkinase_Tyr PF07714.15 NM_182925.4_2 - 1.2e-99 332.7 0.0 1.6e-99 332.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 NM_182925.4_2 - 1.6e-51 172.7 4.7 8.1e-11 42.2 0.0 7.1 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 NM_182925.4_2 - 1e-39 134.4 0.3 1.3e-14 53.9 0.0 8.0 6 2 2 8 8 8 5 Immunoglobulin I-set domain Pkinase PF00069.23 NM_182925.4_2 - 2.5e-39 135.1 0.0 1.1e-27 97.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_2 PF13895.4 NM_182925.4_2 - 1.9e-37 127.3 10.5 5.5e-08 32.9 0.0 9.5 9 1 0 9 9 9 6 Immunoglobulin domain ig PF00047.23 NM_182925.4_2 - 2.5e-30 104.3 2.3 7e-08 32.4 0.1 7.5 7 0 0 7 7 7 4 Immunoglobulin domain V-set PF07686.15 NM_182925.4_2 - 1.1e-14 54.4 7.5 0.0046 17.0 0.0 7.1 6 3 2 8 8 8 3 Immunoglobulin V-set domain Izumo-Ig PF16706.3 NM_182925.4_2 - 2.3e-07 30.6 2.0 1.5 8.8 0.0 5.9 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 NM_182925.4_2 - 0.001 18.9 5.0 2.1 8.4 0.0 4.9 6 0 0 6 6 6 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_182925.4_2 - 0.0025 18.1 1.3 0.42 11.0 0.0 4.6 6 0 0 6 6 6 1 Immunoglobulin C1-set domain FERM_C PF09380.8 NM_001244959.1_2 - 1.8e-18 66.6 0.3 3.4e-18 65.7 0.3 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 NM_001244959.1_2 - 7.7e-18 64.9 0.0 1.4e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.8 NM_001244959.1_2 - 1.5e-16 59.9 0.0 2.5e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 FERM N-terminal domain FA PF08736.9 NM_001244959.1_2 - 1.2e-13 50.8 0.8 2.6e-13 49.7 0.8 1.6 1 0 0 1 1 1 1 FERM adjacent (FA) zf-H2C2_2 PF13465.4 NM_001201459.1_1 - 2e-42 141.6 82.9 5.2e-10 39.2 2.4 10.5 11 0 0 11 11 11 7 Zinc-finger double domain zf-H2C2_5 PF13909.4 NM_001201459.1_1 - 3.6e-35 119.2 58.9 3.2e-05 23.5 0.3 8.3 8 0 0 8 8 8 8 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 NM_001201459.1_1 - 2.2e-19 68.6 94.7 0.00032 20.9 4.6 10.2 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001201459.1_1 - 0.018 15.7 90.4 0.018 15.7 2.9 10.2 11 0 0 11 11 11 0 C2H2-type zinc finger zf-C2HE PF16278.3 NM_001201459.1_1 - 0.051 13.9 38.5 0.87 10.0 0.7 6.8 2 2 5 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.9 NM_001201459.1_1 - 1.2 8.8 26.8 0.13 12.0 0.9 5.5 2 2 2 5 5 5 0 GAGA factor DUF3505 PF12013.6 NM_001201459.1_1 - 2.4 8.5 48.7 0.85 10.0 0.5 8.2 4 2 4 8 8 8 0 Protein of unknown function (DUF3505) CARD PF00619.19 NM_001324281.1_1 - 9.5e-22 76.7 0.0 3.2e-21 75.0 0.0 2.0 1 0 0 1 1 1 1 Caspase recruitment domain PDZ PF00595.22 NM_001324281.1_1 - 0.00016 21.8 0.0 0.00034 20.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Guanylate_kin PF00625.19 NM_001324281.1_1 - 0.00029 20.5 3.6 0.0058 16.2 0.0 2.5 2 0 0 2 2 2 1 Guanylate kinase DUF1664 PF07889.10 NM_001324281.1_1 - 5.4 6.9 21.9 0.091 12.6 2.3 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) CNH PF00780.20 NM_001307990.1_1 - 1e-61 208.9 0.0 1.4e-61 208.4 0.0 1.2 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 NM_001307990.1_1 - 4e-61 206.5 0.0 5.9e-61 206.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001307990.1_1 - 3.8e-39 134.4 0.0 5.6e-39 133.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001307990.1_1 - 0.068 12.3 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like TPR_12 PF13424.4 NM_177417.2_2 - 1.2e-62 208.0 26.2 3.4e-21 75.2 1.5 5.1 3 1 3 6 6 4 4 Tetratricopeptide repeat TPR_10 PF13374.4 NM_177417.2_2 - 6e-51 168.9 15.1 1.3e-16 59.7 0.2 5.9 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.4 NM_177417.2_2 - 1.4e-23 81.0 14.7 6.3e-06 25.7 0.1 5.9 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_1 PF00515.26 NM_177417.2_2 - 5.9e-23 79.5 22.4 2.6e-07 30.0 0.2 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.15 NM_177417.2_2 - 7.8e-16 56.7 26.9 0.00052 19.8 0.4 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.4 NM_177417.2_2 - 6.8e-12 44.5 13.8 0.0045 17.0 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_177417.2_2 - 1.8e-11 44.2 8.9 8.9e-05 22.8 0.7 4.2 2 1 1 4 4 3 3 Tetratricopeptide repeat TPR_17 PF13431.4 NM_177417.2_2 - 1e-08 34.8 6.4 0.026 14.7 0.7 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_177417.2_2 - 2.1e-06 27.9 19.4 1.3 9.9 0.2 7.2 6 1 2 8 8 6 1 Tetratricopeptide repeat SNAP PF14938.4 NM_177417.2_2 - 2.3e-05 23.8 0.1 3.9e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.5 NM_177417.2_2 - 3.8e-05 23.7 6.7 0.047 13.8 0.1 3.3 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.18 NM_177417.2_2 - 0.00038 20.4 0.0 0.22 11.7 0.0 3.4 3 0 0 3 3 3 1 PPR repeat TPR_16 PF13432.4 NM_177417.2_2 - 0.00061 20.3 0.7 0.057 14.0 0.2 6.5 6 1 2 8 8 6 4 Tetratricopeptide repeat Coatomer_E PF04733.12 NM_177417.2_2 - 0.0051 16.1 1.0 2.2 7.5 0.1 2.8 1 1 2 3 3 3 2 Coatomer epsilon subunit PPR_2 PF13041.4 NM_177417.2_2 - 0.013 15.5 0.2 1.3 9.1 0.0 2.8 3 0 0 3 3 2 0 PPR repeat family DUF3450 PF11932.6 NM_177417.2_2 - 0.05 12.7 4.5 0.16 11.1 4.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) SHNi-TPR PF10516.7 NM_177417.2_2 - 0.095 12.1 1.8 17 4.9 0.1 3.8 4 0 0 4 4 4 0 SHNi-TPR JIP_LZII PF16471.3 NM_177417.2_2 - 0.12 12.4 3.8 0.41 10.7 3.8 1.9 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II DUF972 PF06156.11 NM_177417.2_2 - 0.13 12.8 6.6 0.34 11.4 1.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF972) Tox-GHH PF15636.4 NM_177417.2_2 - 0.29 10.9 4.7 0.61 9.9 4.7 1.5 1 0 0 1 1 1 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin TMF_TATA_bd PF12325.6 NM_177417.2_2 - 0.41 10.8 9.2 0.17 12.0 5.4 2.4 2 0 0 2 2 1 0 TATA element modulatory factor 1 TATA binding ATG16 PF08614.9 NM_177417.2_2 - 0.46 10.5 13.6 0.27 11.3 9.9 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) APG6 PF04111.10 NM_177417.2_2 - 0.51 9.5 3.6 0.96 8.6 3.6 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 TPR_3 PF07720.10 NM_177417.2_2 - 0.55 10.2 7.7 4 7.4 1.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_177417.2_2 - 0.75 10.4 10.0 2.4 8.8 0.3 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat IncA PF04156.12 NM_177417.2_2 - 0.94 9.1 15.8 1.7 8.3 15.3 1.7 1 1 0 1 1 1 0 IncA protein Fis1_TPR_C PF14853.4 NM_177417.2_2 - 1 9.3 8.4 3.4 7.7 0.5 3.7 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Cnn_1N PF07989.9 NM_177417.2_2 - 1.7 8.7 7.0 0.78 9.8 3.8 2.1 2 0 0 2 2 1 0 Centrosomin N-terminal motif 1 TPR_4 PF07721.12 NM_177417.2_2 - 3.1 8.6 36.8 0.68 10.6 0.1 8.5 10 0 0 10 10 7 0 Tetratricopeptide repeat Mod_r PF07200.11 NM_177417.2_2 - 9.3 6.2 12.7 0.2 11.6 4.8 2.2 3 0 0 3 3 2 0 Modifier of rudimentary (Mod(r)) protein Ank_2 PF12796.5 NM_005254.5_2 - 5.9e-34 116.4 3.3 5.1e-15 55.7 0.0 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_005254.5_2 - 1.2e-21 76.3 0.6 9.8e-10 38.4 0.0 4.4 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_005254.5_2 - 8.1e-21 73.4 0.5 2e-08 34.2 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.4 NM_005254.5_2 - 1.6e-19 69.8 0.2 8.8e-08 32.4 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_005254.5_2 - 4.3e-18 63.4 0.0 6.7e-06 25.9 0.0 4.9 4 0 0 4 4 4 3 Ankyrin repeat GrpE PF01025.17 NM_005254.5_2 - 6 6.4 10.2 12 5.4 10.2 1.4 1 0 0 1 1 1 0 GrpE Ion_trans PF00520.29 NM_198378.2_3 - 2.6e-253 835.6 69.8 1.2e-78 263.7 11.3 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.10 NM_198378.2_3 - 1.4e-14 53.6 80.4 3.9e-09 35.6 1.9 9.5 6 3 3 9 9 9 6 Polycystin cation channel Ctr PF04145.13 NM_198378.2_3 - 0.29 11.6 3.0 3.2 8.2 0.5 3.8 3 1 0 3 3 3 0 Ctr copper transporter family MscL PF01741.16 NM_198378.2_3 - 0.32 11.2 3.0 27 5.0 0.0 3.2 3 0 0 3 3 3 0 Large-conductance mechanosensitive channel, MscL Neur_chan_memb PF02932.14 NM_198378.2_3 - 1 9.2 5.7 0.41 10.5 0.2 2.9 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region DUF788 PF05620.9 NM_198378.2_3 - 1.1 9.0 6.6 1 9.2 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF788) SelP_N PF04592.12 NM_198378.2_3 - 8.3 5.6 9.4 25 4.0 9.4 1.8 1 0 0 1 1 1 0 Selenoprotein P, N terminal region L_HMGIC_fpl PF10242.7 NM_198560.2_2 - 6.2e-67 225.2 15.6 8.8e-67 224.7 15.6 1.2 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.4 NM_198560.2_2 - 0.0058 16.3 12.3 0.009 15.7 10.7 1.9 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 NM_198560.2_2 - 0.042 13.6 11.3 0.066 12.9 11.3 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Pkinase PF00069.23 NM_001322236.1_3 - 7.4e-128 425.3 4.4 1.8e-72 243.8 0.1 3.1 2 1 1 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001322236.1_3 - 1.1e-57 195.1 3.9 2.3e-31 108.9 0.0 3.1 2 1 1 3 3 3 3 Protein tyrosine kinase Kdo PF06293.12 NM_001322236.1_3 - 1.1e-10 41.1 1.3 5.8e-08 32.2 0.1 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_001322236.1_3 - 3.2e-10 39.7 0.8 0.00016 20.9 0.0 3.5 3 1 0 4 4 4 2 Kinase-like Pkinase_C PF00433.22 NM_001322236.1_3 - 8.6e-09 35.8 0.5 1.9e-08 34.7 0.5 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.21 NM_001322236.1_3 - 2e-08 34.3 1.4 0.0003 20.7 0.0 3.6 2 2 2 4 4 4 2 Phosphotransferase enzyme family FTA2 PF13095.4 NM_001322236.1_3 - 4.7e-05 23.0 0.8 1.8 8.0 0.0 3.2 3 0 0 3 3 3 3 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.20 NM_001322236.1_3 - 5.8e-05 22.6 2.3 0.00076 19.0 0.2 2.3 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.18 NM_001322236.1_3 - 0.043 13.3 2.0 0.099 12.1 0.1 2.3 3 0 0 3 3 3 0 Choline/ethanolamine kinase JmjC PF02373.20 NM_001258251.1_1 - 7.5e-34 116.5 1.4 2.3e-33 114.9 1.4 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase TPR_1 PF00515.26 NM_001258251.1_1 - 1e-24 85.1 19.1 1.4e-05 24.6 0.0 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001258251.1_1 - 5.4e-14 51.0 18.9 0.13 12.3 0.1 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001258251.1_1 - 5e-13 48.0 17.0 0.0052 16.8 0.4 7.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001258251.1_1 - 7.7e-13 48.8 0.5 0.11 13.1 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001258251.1_1 - 4e-12 45.5 0.7 0.0082 16.3 0.0 4.5 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001258251.1_1 - 2.6e-08 33.9 9.5 0.31 11.2 0.1 4.8 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001258251.1_1 - 1.6e-06 28.3 2.1 2.4 9.1 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001258251.1_1 - 4.4e-06 27.0 9.5 0.06 13.7 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001258251.1_1 - 5.8e-06 25.8 9.9 0.61 10.1 0.2 6.1 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001258251.1_1 - 0.00026 21.0 2.5 0.012 15.7 0.1 3.6 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001258251.1_1 - 0.005 16.4 11.9 0.14 11.7 0.0 5.6 3 2 3 6 6 6 1 TPR repeat TPR_15 PF13429.4 NM_001258251.1_1 - 0.27 10.3 7.1 0.4 9.7 3.3 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001258251.1_1 - 0.37 11.4 10.5 4 8.2 0.1 6.4 8 0 0 8 8 7 0 Tetratricopeptide repeat KRAB PF01352.25 NM_001291745.1_1 - 2.4e-24 84.6 1.0 4.4e-24 83.7 1.0 1.5 1 0 0 1 1 1 1 KRAB box Dopey_N PF04118.12 NM_001199942.1_3 - 1e-115 385.9 0.9 8.2e-115 383.0 0.1 2.9 3 0 0 3 3 3 1 Dopey, N-terminal PNTB PF02233.14 NM_001199942.1_3 - 0.048 12.4 0.3 0.079 11.7 0.3 1.2 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit SCAN PF02023.15 NM_001320954.1_1 - 4.8e-41 138.4 3.0 9.9e-41 137.4 3.0 1.6 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 NM_001320954.1_1 - 3.4e-34 115.6 33.8 2.7e-08 33.8 0.4 6.9 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001320954.1_1 - 3.8e-25 86.8 33.6 8.3e-07 29.0 1.0 6.0 6 0 0 6 6 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001320954.1_1 - 1e-12 47.6 30.4 0.0043 17.6 0.7 6.0 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001320954.1_1 - 1.2e-09 37.8 24.3 0.17 11.8 0.7 5.9 5 0 0 5 5 5 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001320954.1_1 - 8.3e-05 22.5 19.4 0.016 15.2 3.0 3.9 2 1 1 3 3 3 3 Zinc ribbon domain XPA_N PF01286.16 NM_001320954.1_1 - 0.0021 17.9 21.8 0.23 11.4 0.4 5.3 5 0 0 5 5 5 2 XPA protein N-terminal zf-trcl PF13451.4 NM_001320954.1_1 - 0.011 15.4 16.4 9.5 6.1 0.1 5.4 5 0 0 5 5 5 0 Probable zinc-ribbon domain DZR PF12773.5 NM_001320954.1_1 - 0.086 12.8 15.1 0.78 9.7 4.8 3.3 1 1 1 2 2 2 0 Double zinc ribbon HypA PF01155.17 NM_001320954.1_1 - 0.15 11.9 11.6 4.6 7.2 3.6 3.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 NM_001320954.1_1 - 0.15 12.7 14.9 2.8 8.6 1.4 3.2 1 1 2 3 3 3 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_001320954.1_1 - 0.25 11.6 16.8 2.8 8.2 0.1 5.2 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding YhfH PF14149.4 NM_001320954.1_1 - 0.99 9.3 17.0 25 4.8 0.1 5.5 5 0 0 5 5 5 0 YhfH-like protein zf-C2H2_11 PF16622.3 NM_001320954.1_1 - 1.1 8.9 18.1 0.19 11.4 0.3 5.0 5 0 0 5 5 5 0 zinc-finger C2H2-type DUF3268 PF11672.6 NM_001320954.1_1 - 1.2 9.4 11.9 0.52 10.5 1.3 2.9 1 1 1 3 3 3 0 zinc-finger-containing domain DUF2321 PF10083.7 NM_001320954.1_1 - 2 7.9 11.9 1.4 8.4 1.7 3.1 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-LYAR PF08790.9 NM_001320954.1_1 - 2.1 8.2 14.9 0.82 9.5 0.3 4.5 5 0 0 5 5 4 0 LYAR-type C2HC zinc finger ADK_lid PF05191.12 NM_001320954.1_1 - 2.4 8.2 12.4 4.7 7.2 1.7 4.1 3 1 2 5 5 4 0 Adenylate kinase, active site lid CpXC PF14353.4 NM_001320954.1_1 - 5.7 6.9 11.9 8.4 6.3 0.0 4.6 2 1 2 4 4 4 0 CpXC protein zf-AN1 PF01428.14 NM_001320954.1_1 - 7.8 6.6 22.9 20 5.3 0.2 5.4 4 1 1 5 5 5 0 AN1-like Zinc finger TFIIS_C PF01096.16 NM_001320954.1_1 - 8.1 6.3 19.1 14 5.5 0.4 5.3 5 0 0 5 5 5 0 Transcription factor S-II (TFIIS) C1_4 PF07975.10 NM_001320954.1_1 - 9.8 6.4 16.5 4.5 7.5 1.4 3.7 2 1 2 4 4 4 0 TFIIH C1-like domain CDC37_M PF08565.9 NM_017913.3_3 - 3.8e-21 75.1 0.8 6.5e-21 74.3 0.2 1.7 1 1 1 2 2 2 1 Cdc37 Hsp90 binding domain Exo_endo_phos PF03372.21 NM_019892.5_2 - 2.1e-06 27.8 0.0 3.2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Y_phosphatase PF00102.25 NM_130846.2_2 - 9.5e-75 251.0 0.2 1.3e-74 250.6 0.2 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 NM_130846.2_2 - 0.00016 21.4 0.0 0.00032 20.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_130846.2_2 - 0.00088 19.2 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF3149 PF11346.6 NM_130846.2_2 - 3.4 7.2 5.3 11 5.6 5.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) CLASP_N PF12348.6 NM_001207044.1_3 - 7.7e-42 143.3 6.4 3.9e-39 134.4 0.1 3.2 3 0 0 3 3 3 2 CLASP N terminal HEAT PF02985.20 NM_001207044.1_3 - 2.5e-07 30.2 9.8 0.14 12.3 0.0 7.2 8 0 0 8 8 8 2 HEAT repeat HEAT_EZ PF13513.4 NM_001207044.1_3 - 1e-06 28.9 0.2 0.024 15.0 0.0 4.5 4 0 0 4 4 4 1 HEAT-like repeat RTP1_C1 PF10363.7 NM_001207044.1_3 - 5.4e-05 23.2 2.0 0.031 14.3 0.1 3.4 3 1 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.5 NM_001207044.1_3 - 0.00024 21.0 2.0 0.0036 17.2 0.8 3.3 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 TFCD_C PF12612.6 NM_001207044.1_3 - 0.0074 16.0 0.3 0.089 12.5 0.1 2.7 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal TAN PF11640.6 NM_001207044.1_3 - 0.011 15.7 1.7 0.17 11.9 0.1 3.5 3 1 0 3 3 3 0 Telomere-length maintenance and DNA damage repair Ipi1_N PF12333.6 NM_001207044.1_3 - 0.014 15.9 0.8 1.1 9.8 0.0 3.4 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation ParcG PF10274.7 NM_001207044.1_3 - 0.06 13.3 0.3 0.19 11.7 0.1 1.9 2 0 0 2 2 2 0 Parkin co-regulated protein MMS19_C PF12460.6 NM_001207044.1_3 - 0.13 11.3 6.6 0.71 8.8 0.5 3.1 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal AbLIM_anchor PF16182.3 NM_001323395.1_3 - 1.4e-80 271.8 11.2 5.4e-60 204.0 7.4 2.1 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 NM_001323395.1_3 - 1.1e-14 54.1 0.8 2.2e-14 53.1 0.8 1.6 1 0 0 1 1 1 1 Villin headpiece domain STAT1_TAZ2bind PF12162.6 NM_001323395.1_3 - 0.046 13.2 0.8 6.4 6.3 0.0 2.7 2 0 0 2 2 2 0 STAT1 TAZ2 binding domain Laminin_N PF00055.15 NM_014917.3_1 - 4.6e-54 183.4 0.0 4.6e-54 183.4 0.0 2.0 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.22 NM_014917.3_1 - 3.4e-06 26.9 11.1 3.4e-06 26.9 11.1 3.1 3 0 0 3 3 3 1 Laminin EGF domain EGF_2 PF07974.11 NM_014917.3_1 - 0.74 10.1 25.1 0.014 15.6 6.8 3.5 3 0 0 3 3 3 0 EGF-like domain MARVEL PF01284.21 NM_002668.2_3 - 1.7e-12 47.4 11.3 3.1e-12 46.6 11.3 1.4 1 0 0 1 1 1 1 Membrane-associating domain AC_N PF16214.3 NM_002668.2_3 - 0.062 12.3 0.4 0.079 11.9 0.4 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF2070 PF09843.7 NM_002668.2_3 - 0.77 7.8 5.4 0.99 7.5 5.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Myosin_tail_1 PF01576.17 NM_001040113.1_3 - 0 1688.3 313.7 0 1688.1 313.7 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 NM_001040113.1_3 - 0 1021.8 1.7 0 1021.8 1.7 3.8 4 0 0 4 4 4 1 Myosin head (motor domain) Myosin_N PF02736.17 NM_001040113.1_3 - 2e-14 53.0 4.5 4.6e-14 51.8 4.5 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 NM_001040113.1_3 - 0.00024 20.5 71.0 0.0022 17.3 4.6 8.6 3 2 5 10 10 10 5 Reovirus sigma C capsid protein CC2-LZ PF16516.3 NM_001040113.1_3 - 0.00075 19.7 17.4 0.00075 19.7 17.4 17.4 3 2 14 17 17 17 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator IQ PF00612.25 NM_001040113.1_3 - 0.00081 18.8 0.1 0.0031 17.0 0.1 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_22 PF13401.4 NM_001040113.1_3 - 0.057 13.6 0.0 0.057 13.6 0.0 8.2 6 2 1 9 9 9 0 AAA domain DUF3970 PF13113.4 NM_001040113.1_3 - 1.7 8.8 5.9 1.5 8.9 0.9 3.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) Ribosomal_L11 PF00298.17 NM_170738.3_2 - 1e-21 77.1 0.1 1.9e-21 76.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.12 NM_170738.3_2 - 7.4e-12 44.7 0.0 1.3e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Cadherin PF00028.15 NM_024421.2_2 - 2.3e-85 281.0 2.5 1.6e-21 76.4 0.0 5.7 6 0 0 6 6 6 5 Cadherin domain Cadherin_pro PF08758.9 NM_024421.2_2 - 1.1e-21 76.6 0.0 2.8e-19 68.9 0.0 2.7 2 0 0 2 2 2 2 Cadherin prodomain like Cadherin_C PF01049.15 NM_024421.2_2 - 3e-06 27.4 0.0 6.4e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.10 NM_024421.2_2 - 3.8e-06 26.5 0.0 0.33 10.7 0.0 3.5 3 0 0 3 3 3 2 Cadherin-like Cadherin_3 PF16184.3 NM_024421.2_2 - 0.049 13.5 5.0 0.57 10.1 0.6 3.2 4 0 0 4 4 4 0 Cadherin-like RNB PF00773.17 NM_001323939.1_3 - 5.7e-88 295.2 0.0 9.1e-88 294.6 0.0 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.1 NM_001323939.1_3 - 7.7e-07 28.9 0.0 3.7e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 S1 domain Rrp44_CSD1 PF17216.1 NM_001323939.1_3 - 1.7e-06 27.7 0.0 3.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain Reticulon PF02453.15 NM_207521.1_1 - 2.6e-46 157.3 6.7 3.9e-46 156.7 6.7 1.3 1 0 0 1 1 1 1 Reticulon DUF639 PF04842.10 NM_207521.1_1 - 0.065 12.5 2.1 0.15 11.4 2.1 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) 7tm_1 PF00001.19 NM_178129.4_3 - 3.4e-36 124.7 23.9 4.6e-36 124.3 23.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 NM_178129.4_3 - 0.92 8.6 14.2 1.5 7.9 14.2 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Na_Pi_cotrans PF02690.13 NM_001177998.1_1 - 1.4e-37 128.7 25.1 2.4e-23 82.7 10.2 2.4 2 0 0 2 2 2 2 Na+/Pi-cotransporter DUF1127 PF06568.9 NM_001177998.1_2 - 5.1 6.8 8.3 9 6.0 8.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) Yos1 PF08571.8 NM_016097.4_2 - 2.4e-29 101.3 0.5 3.8e-29 100.6 0.5 1.3 1 0 0 1 1 1 1 Yos1-like Connexin PF00029.17 NM_005497.3_2 - 4.5e-98 327.4 0.2 6.9e-98 326.8 0.2 1.3 1 0 0 1 1 1 1 Connexin TLP-20 PF06088.9 NM_005497.3_2 - 0.091 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RRM_7 PF16367.3 NM_001308189.1_3 - 4.6e-35 119.5 0.0 7.8e-34 115.5 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.3 NM_001308189.1_3 - 6.3e-20 71.0 5.2 1.7e-19 69.6 5.2 1.8 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.20 NM_001308189.1_3 - 4.5e-11 42.3 0.0 1.2e-06 28.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HSP20 PF00011.19 NM_001320719.1_1 - 1.6e-21 76.2 0.0 2e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family zf-H2C2_2 PF13465.4 NM_001199295.1_1 - 6.6e-82 266.4 101.6 2.2e-08 34.0 0.6 16.3 16 0 0 16 16 16 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001199295.1_1 - 2.9e-52 172.2 118.0 2.9e-05 24.1 0.8 16.9 17 0 0 17 17 17 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001199295.1_1 - 2.4e-25 86.9 118.7 0.013 16.2 1.1 17.4 18 0 0 18 18 18 13 C2H2-type zinc finger KRAB PF01352.25 NM_001199295.1_1 - 1.1e-22 79.3 0.2 1.1e-22 79.3 0.2 1.8 2 0 0 2 2 2 1 KRAB box zf-C2H2_6 PF13912.4 NM_001199295.1_1 - 5.6e-13 48.4 82.8 0.035 13.9 0.7 13.7 13 0 0 13 13 13 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001199295.1_1 - 3e-06 27.1 59.8 0.4 10.7 0.8 8.5 5 3 2 8 8 8 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001199295.1_1 - 2.3e-05 24.4 80.3 0.067 13.4 0.0 14.2 15 0 0 15 15 15 7 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001199295.1_1 - 0.0037 17.8 50.9 1.3 9.7 1.2 7.3 1 1 6 7 7 7 5 zinc-ribbon family zf-C2H2_8 PF15909.3 NM_001199295.1_1 - 0.023 14.8 56.6 0.28 11.3 2.2 7.5 1 1 7 8 8 8 0 C2H2-type zinc ribbon DUF4547 PF15080.4 NM_001320473.1_1 - 3.5e-122 405.2 3.1 4.5e-122 404.9 3.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4547) Claudin_2 PF13903.4 NM_001290098.1_1 - 1.1e-07 31.6 0.0 1.4e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 NM_001290098.1_1 - 0.0023 17.7 0.0 0.0031 17.3 0.0 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family EF-hand_1 PF00036.30 NM_004276.4_3 - 3.4e-30 101.2 12.4 1.3e-09 36.8 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 NM_004276.4_3 - 1.5e-25 89.4 6.2 6.1e-15 55.3 0.8 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_004276.4_3 - 2.3e-25 86.2 2.2 5.9e-09 35.0 0.1 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 NM_004276.4_3 - 1.8e-21 75.5 9.2 7.8e-12 44.6 0.4 3.6 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 NM_004276.4_3 - 1.5e-19 68.4 8.7 7.5e-08 31.4 0.1 3.7 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.4 NM_004276.4_3 - 1.5e-08 34.7 0.1 0.0026 17.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.7 NM_004276.4_3 - 0.00022 21.4 0.0 0.018 15.2 0.0 2.3 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.11 NM_004276.4_3 - 0.0041 16.9 0.0 0.78 9.6 0.0 2.3 2 0 0 2 2 2 1 Tellurite resistance protein TerB EF-hand_4 PF12763.5 NM_004276.4_3 - 0.032 14.0 0.9 0.24 11.3 0.1 2.4 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DIMCO_N PF16844.3 NM_004276.4_3 - 0.047 13.9 0.1 0.13 12.5 0.0 1.7 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal POTRA_2 PF08479.9 NM_004276.4_3 - 0.067 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 POTRA domain, ShlB-type Caleosin PF05042.11 NM_004276.4_3 - 0.085 12.6 0.0 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Caleosin related protein Dockerin_1 PF00404.16 NM_004276.4_3 - 3.7 7.5 10.3 4.4 7.2 1.4 3.2 3 0 0 3 3 3 0 Dockerin type I repeat BTB_2 PF02214.20 NM_001319295.1_2 - 5.5e-22 77.8 0.0 1e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain WD40 PF00400.30 NM_001319295.1_2 - 0.5 11.2 3.7 33 5.5 0.0 4.1 5 0 0 5 5 5 0 WD domain, G-beta repeat EF-hand_7 PF13499.4 NM_024329.5_3 - 2.9e-07 30.7 1.5 5.8e-07 29.8 1.5 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_024329.5_3 - 1.7e-06 27.0 9.5 0.00022 20.4 2.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_024329.5_3 - 1.8e-06 27.3 1.7 0.00016 21.2 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.4 NM_024329.5_3 - 0.0046 16.3 0.2 0.0046 16.3 0.2 2.3 3 0 0 3 3 3 1 EF hand SPARC_Ca_bdg PF10591.7 NM_024329.5_3 - 0.049 13.8 0.0 0.049 13.8 0.0 1.7 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.4 NM_024329.5_3 - 3.1 7.5 6.4 11 5.7 0.9 2.3 1 1 1 2 2 2 0 EF-hand domain pair LRR_8 PF13855.4 NM_005582.2_2 - 2.6e-47 158.3 71.0 1.5e-09 37.3 2.9 10.5 5 3 4 10 10 10 9 Leucine rich repeat LRR_4 PF12799.5 NM_005582.2_2 - 1.2e-17 63.5 68.0 0.00045 20.4 5.3 12.0 8 4 6 14 14 14 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_005582.2_2 - 0.00019 21.3 76.8 0.13 12.7 0.2 17.1 17 3 1 18 18 18 6 Leucine Rich Repeat LRR_9 PF14580.4 NM_005582.2_2 - 0.00094 18.6 19.3 0.42 10.0 0.2 5.9 2 2 4 7 7 7 2 Leucine-rich repeat LRRCT PF01463.22 NM_005582.2_2 - 0.056 13.9 0.0 0.31 11.6 0.0 2.4 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain Methyltr_RsmB-F PF01189.15 NM_182543.3_3 - 4.9e-45 153.5 0.0 7.5e-45 152.9 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.4 NM_182543.3_3 - 2.6e-07 30.4 0.0 4.2e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.17 NM_182543.3_3 - 1.1e-06 28.8 0.0 2e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PUA PF01472.18 NM_182543.3_3 - 0.00013 21.7 0.1 0.00028 20.7 0.1 1.5 1 0 0 1 1 1 1 PUA domain PCMT PF01135.17 NM_182543.3_3 - 0.029 14.0 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.8 NM_182543.3_3 - 0.09 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Mitoc_L55 PF09776.7 NM_181456.2_3 - 5.4e-54 180.8 3.5 7.1e-54 180.4 3.5 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 SNF2_N PF00176.21 NM_001322253.1_2 - 1.7e-49 168.3 0.0 2.9e-49 167.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 NM_001322253.1_2 - 7e-14 52.0 0.0 1.2e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_001322253.1_2 - 1.3e-07 31.6 0.0 3e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 NM_001322253.1_2 - 0.011 14.9 0.0 3.6 6.6 0.0 2.2 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase fn3 PF00041.19 NM_001323506.1_1 - 5e-22 77.9 7.4 2e-05 24.7 0.0 6.0 6 0 0 6 6 6 4 Fibronectin type III domain EpoR_lig-bind PF09067.8 NM_001323506.1_1 - 0.11 12.5 3.9 0.16 12.0 2.3 2.2 2 0 0 2 2 2 0 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.8 NM_001323506.1_1 - 2.2 8.6 6.2 1.9 8.8 0.9 3.6 4 1 1 5 5 5 0 Interleukin-6 receptor alpha chain, binding Metallophos PF00149.26 NM_001009552.1_2 - 2.3e-34 119.5 0.5 3.7e-34 118.9 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 NM_001009552.1_2 - 0.014 15.6 0.3 0.031 14.6 0.3 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain RRM_1 PF00076.20 NM_002139.3_1 - 5.6e-23 80.4 0.1 9.6e-23 79.7 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 NM_002139.3_1 - 1.6e-22 79.1 14.1 1.6e-22 79.1 14.1 8.7 5 2 3 8 8 8 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 NM_002139.3_1 - 0.0054 16.7 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.4 NM_002139.3_1 - 0.027 13.9 0.0 0.048 13.1 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_002139.3_1 - 0.13 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif MRP PF09387.8 NM_001171945.1_3 - 4.4e-69 232.3 1.2 5.9e-69 231.9 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial RNA binding protein MRP Defensin_beta PF00711.17 NM_001081551.3_3 - 1.1e-10 41.2 10.8 1.9e-10 40.4 10.8 1.4 1 0 0 1 1 1 1 Beta defensin ANTH PF07651.14 NM_003959.2_3 - 9.9e-77 257.5 3.8 2e-76 256.5 0.0 2.4 2 0 0 2 2 2 1 ANTH domain I_LWEQ PF01608.15 NM_003959.2_3 - 3.2e-52 176.7 7.1 3.2e-52 176.7 7.1 4.4 4 1 0 4 4 4 1 I/LWEQ domain HIP1_clath_bdg PF16515.3 NM_003959.2_3 - 1.2e-29 102.6 22.1 1.2e-29 102.6 22.1 5.3 4 1 1 5 5 5 1 Clathrin-binding domain of Huntingtin-interacting protein 1 SPRY PF00622.26 NM_033219.2_1 - 6.6e-15 55.2 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 NM_033219.2_1 - 1.1e-10 41.3 0.8 2.3e-10 40.3 0.8 1.4 1 0 0 1 1 1 1 B-box zinc finger PRY PF13765.4 NM_033219.2_1 - 3.4e-09 36.1 0.2 3.4e-09 36.1 0.2 1.8 2 0 0 2 2 2 1 SPRY-associated domain DUF3919 PF13057.4 NM_033219.2_1 - 0.2 11.1 2.3 0.28 10.6 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) NACHT PF05729.10 NM_001144990.1_1 - 2.7e-07 30.5 0.0 6.8e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.4 NM_001144990.1_1 - 1.7e-05 25.1 0.0 4.2e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain DUF4062 PF13271.4 NM_001144990.1_1 - 2.6e-05 24.4 0.0 0.00017 21.7 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) ANAPC4_WD40 PF12894.5 NM_001144990.1_1 - 9.7e-05 22.5 3.2 2.6 8.3 0.0 5.4 4 2 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain AAA_22 PF13401.4 NM_001144990.1_1 - 0.00045 20.4 0.0 0.002 18.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.27 NM_001144990.1_1 - 0.0028 18.0 0.1 0.038 14.3 0.0 2.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.4 NM_001144990.1_1 - 0.02 15.0 0.0 0.05 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain PQQ_2 PF13360.4 NM_001144990.1_1 - 0.041 13.3 0.1 0.81 9.1 0.0 2.3 2 0 0 2 2 2 0 PQQ-like domain STN1_2 PF09170.8 NM_001144990.1_1 - 0.043 13.9 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Ig_2 PF13895.4 NM_001291316.1_1 - 3.4e-07 30.4 0.3 3.4e-07 30.4 0.3 1.7 2 0 0 2 2 2 1 Immunoglobulin domain SIT PF15330.4 NM_001291316.1_1 - 0.00089 19.5 0.2 0.0024 18.1 0.1 1.8 1 1 1 2 2 2 1 SHP2-interacting transmembrane adaptor protein, SIT Ig_3 PF13927.4 NM_001291316.1_1 - 0.0032 17.9 0.0 0.007 16.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 NM_001291316.1_1 - 0.034 14.2 0.2 0.061 13.4 0.2 1.4 1 0 0 1 1 1 0 Immunoglobulin domain DUF4916 PF16262.3 NM_001291316.1_1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4916) PDEase_I PF00233.17 NM_001083.3_3 - 3.5e-77 259.2 1.6 3.5e-77 259.2 1.6 2.0 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 NM_001083.3_3 - 1.7e-31 109.4 0.0 9.9e-15 55.1 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.4 NM_001083.3_3 - 9.5e-07 29.1 0.0 0.0025 18.0 0.0 2.3 2 0 0 2 2 2 2 GAF domain RGM_C PF06534.11 NM_001316767.1_1 - 1.5e-59 200.2 0.0 2.1e-59 199.7 0.0 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus tRNA-synt_1 PF00133.20 NM_013417.3_3 - 8.5e-253 839.9 0.0 1.3e-252 839.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.11 NM_013417.3_3 - 7.1e-23 81.1 0.0 2.4e-22 79.4 0.0 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.9 NM_013417.3_3 - 1.7e-15 56.6 0.1 1.9e-05 23.5 0.0 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.17 NM_013417.3_3 - 0.0013 18.0 0.0 0.011 14.9 0.0 2.4 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain DUF1725 PF08333.9 NM_016116.2_1 - 2.7e-10 39.5 0.4 6.6e-10 38.2 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Ank_2 PF12796.5 NM_016116.2_3 - 1.1e-20 73.9 8.6 2.6e-12 47.0 0.8 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 NM_016116.2_3 - 2e-18 65.8 10.9 0.00026 21.2 0.1 7.1 5 2 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.4 NM_016116.2_3 - 3.4e-17 62.4 9.2 2.2e-06 28.0 0.3 5.5 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_016116.2_3 - 1.6e-14 53.6 11.7 3.4e-05 23.9 0.4 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_016116.2_3 - 3e-13 48.5 8.7 0.00051 20.2 0.1 7.1 7 0 0 7 7 7 3 Ankyrin repeat SOCS_box PF07525.14 NM_016116.2_3 - 4e-08 33.4 7.9 9.6e-08 32.1 7.9 1.7 1 0 0 1 1 1 1 SOCS box Pescadillo_N PF06732.9 NM_001243225.1_3 - 1.7e-130 434.4 2.7 1.7e-130 434.4 2.7 2.0 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.3 NM_001243225.1_3 - 4.9e-10 39.5 0.0 9.3e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.24 NM_001243225.1_3 - 0.0025 18.1 0.0 0.007 16.6 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DNA_pol_phi PF04931.11 NM_001243225.1_3 - 1.1 7.2 15.0 2.1 6.2 15.0 1.4 1 0 0 1 1 1 0 DNA polymerase phi BAR PF03114.16 NM_004305.3_1 - 1.4e-44 152.4 12.4 2e-44 151.9 12.4 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 NM_004305.3_1 - 3.9e-10 39.3 0.1 8.5e-10 38.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_004305.3_1 - 1.4e-06 27.8 0.0 4e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_004305.3_1 - 2.6e-06 26.8 0.1 5.7e-06 25.7 0.1 1.6 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.3 NM_004305.3_1 - 0.00067 19.3 12.4 0.00085 18.9 8.8 2.2 1 1 1 2 2 2 1 BAR domain of APPL family OmpH PF03938.12 NM_004305.3_1 - 0.021 14.7 13.5 0.035 14.0 1.1 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3104 PF11302.6 NM_004305.3_1 - 0.18 11.4 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) Jnk-SapK_ap_N PF09744.7 NM_004305.3_1 - 0.39 10.8 13.4 0.031 14.4 2.4 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.10 NM_004305.3_1 - 3.8 7.4 8.6 1 9.3 1.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) IncA PF04156.12 NM_004305.3_1 - 5 6.7 9.4 9.8 5.8 0.9 2.4 2 0 0 2 2 2 0 IncA protein Pkinase PF00069.23 NM_001282482.1_3 - 5.2e-65 219.3 0.0 9e-65 218.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001282482.1_3 - 5.8e-30 104.3 0.0 1.3e-29 103.2 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase cNMP_binding PF00027.27 NM_001282482.1_3 - 5.9e-20 71.0 0.1 1e-19 70.2 0.1 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Kinase-like PF14531.4 NM_001282482.1_3 - 0.00063 19.0 0.0 0.00094 18.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FeoB_N PF02421.16 NM_001282482.1_3 - 0.1 12.0 0.1 0.17 11.3 0.1 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B APH PF01636.21 NM_001282482.1_3 - 0.16 11.7 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.23 NM_001289101.1_3 - 9.7e-08 31.5 0.0 1.4e-06 27.8 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain WH2 PF02205.18 NM_001289101.1_3 - 9.1e-07 28.4 0.1 2e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 WH2 motif Pkinase_Tyr PF07714.15 NM_001289101.1_3 - 5.5e-06 25.7 0.0 0.00017 20.9 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase MNR PF15718.3 NM_001289101.1_3 - 0.0039 15.3 0.9 0.0055 14.8 0.9 1.1 1 0 0 1 1 1 1 Protein moonraker Rrn6 PF10214.7 NM_001289101.1_3 - 0.012 13.9 7.2 0.017 13.5 7.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CAP_N PF01213.17 NM_001289101.1_3 - 0.21 10.9 11.2 0.35 10.2 11.2 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DHFR_1 PF00186.17 NM_001195643.1_1 - 1.6e-28 99.3 0.0 2.2e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Dihydrofolate reductase Integrin_beta PF00362.16 NM_000213.4_2 - 3e-104 347.9 0.0 4.6e-104 347.4 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain fn3 PF00041.19 NM_000213.4_2 - 6e-73 241.1 0.6 1.5e-18 66.8 0.1 4.6 4 0 0 4 4 4 4 Fibronectin type III domain Calx-beta PF03160.12 NM_000213.4_2 - 4.3e-24 84.4 0.0 1.4e-23 82.8 0.0 2.0 1 0 0 1 1 1 1 Calx-beta domain Integrin_B_tail PF07965.10 NM_000213.4_2 - 9e-18 64.4 6.4 9e-18 64.4 6.4 3.1 3 0 0 3 3 3 1 Integrin beta tail domain PSI_integrin PF17205.1 NM_000213.4_2 - 4.5e-10 39.1 9.4 4.5e-10 39.1 9.4 3.9 3 1 0 3 3 3 1 Integrin plexin domain Pur_ac_phosph_N PF16656.3 NM_000213.4_2 - 4.2e-07 30.3 0.0 0.1 13.0 0.0 5.1 4 1 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.11 NM_000213.4_2 - 1.5e-06 28.3 85.8 9.3e-05 22.6 9.6 5.3 5 0 0 5 5 5 4 EGF-like domain SEA PF01390.18 NM_000213.4_2 - 0.017 15.3 0.0 0.044 13.9 0.0 1.7 1 0 0 1 1 1 0 SEA domain CH PF00307.29 NM_001282338.1_1 - 2.4e-90 297.9 2.2 2.5e-25 88.7 0.1 4.4 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.4 NM_001282338.1_1 - 1.4e-07 31.8 0.1 4e-07 30.3 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_001282338.1_1 - 5.8e-06 25.3 2.6 0.00013 21.1 0.7 2.7 2 0 0 2 2 2 1 EF hand CAMSAP_CH PF11971.6 NM_001282338.1_1 - 8.1e-05 22.2 0.0 0.00076 19.1 0.0 2.4 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_5 PF13202.4 NM_001282338.1_1 - 0.0024 17.2 2.5 0.0053 16.1 0.2 2.8 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.4 NM_001282338.1_1 - 0.0082 15.8 0.1 0.032 13.9 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_001282338.1_1 - 0.014 15.2 0.7 0.12 12.3 0.2 2.7 2 0 0 2 2 2 0 EF-hand domain Ank_2 PF12796.5 NM_007332.2_2 - 2e-98 323.0 38.9 4.4e-18 65.5 2.8 8.4 2 1 7 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.28 NM_007332.2_2 - 1.2e-57 189.8 23.0 9.4e-07 28.9 0.0 14.8 15 0 0 15 15 15 12 Ankyrin repeat Ank_4 PF13637.4 NM_007332.2_2 - 3.4e-57 190.0 18.6 1.8e-08 34.6 0.2 11.2 3 2 11 14 14 14 13 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_007332.2_2 - 8e-56 179.3 15.8 5.6e-05 23.1 0.0 15.6 15 0 0 15 15 15 12 Ankyrin repeat Ank_5 PF13857.4 NM_007332.2_2 - 6e-52 172.7 15.2 2.9e-07 30.5 0.1 12.6 4 3 8 13 13 13 11 Ankyrin repeats (many copies) Ion_trans PF00520.29 NM_007332.2_2 - 2.6e-13 49.6 19.0 2.6e-13 49.6 19.0 2.2 2 0 0 2 2 2 1 Ion transport protein Perilipin PF03036.14 NM_001080400.1_1 - 5.5e-78 262.6 168.1 2.1e-30 105.9 0.1 23.3 2 2 25 27 27 27 27 Perilipin family Apolipoprotein PF01442.16 NM_001080400.1_1 - 3.1e-14 53.2 0.0 0.17 11.7 0.0 7.1 1 1 6 7 7 7 7 Apolipoprotein A1/A4/E domain ACP_syn_III PF08545.8 NM_001080400.1_1 - 5.6e-08 32.4 110.0 0.47 10.2 0.2 21.9 3 3 19 23 23 23 10 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Herpes_IE1 PF07340.9 NM_001080400.1_1 - 0.2 10.4 12.8 39 2.9 0.1 6.9 2 2 3 8 8 8 0 Cytomegalovirus IE1 protein Nsp1 PF11501.6 NM_001080400.1_1 - 4.5 7.2 10.6 53 3.8 0.1 6.3 4 3 3 8 8 8 0 Non structural protein Nsp1 Chorion_2 PF03964.13 NM_001289127.1_1 - 8.9 7.1 6.8 26 5.6 6.8 1.7 1 0 0 1 1 1 0 Chorion family 2 Tubulin PF00091.23 NM_001289127.1_3 - 1.3e-67 227.7 0.0 1.8e-67 227.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_001289127.1_3 - 1.1e-41 141.9 0.1 1.6e-41 141.3 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 NM_001289127.1_3 - 4.4e-05 23.6 0.0 8.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 NM_001289127.1_3 - 0.035 13.7 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 NM_001289127.1_3 - 0.041 13.0 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Ras PF00071.20 NM_005343.3_2 - 5.7e-58 195.0 0.1 6.9e-58 194.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_005343.3_2 - 3.6e-21 75.5 0.0 5.6e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_005343.3_2 - 7.7e-09 35.1 0.0 9.8e-09 34.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 NM_005343.3_2 - 8.1e-06 25.4 0.2 3.4e-05 23.3 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 NM_005343.3_2 - 2.6e-05 24.1 0.0 0.076 12.8 0.0 2.4 2 1 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 NM_005343.3_2 - 8.6e-05 22.5 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 NM_005343.3_2 - 0.0023 17.3 0.0 0.012 15.0 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.10 NM_005343.3_2 - 0.037 13.2 0.0 0.047 12.9 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region G-alpha PF00503.18 NM_005343.3_2 - 0.077 12.0 0.0 1.6 7.7 0.0 2.0 1 1 1 2 2 2 0 G-protein alpha subunit ATP_bind_1 PF03029.15 NM_005343.3_2 - 0.091 12.4 0.3 1.3 8.6 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Septin PF00735.16 NM_005343.3_2 - 0.12 11.4 0.0 0.21 10.7 0.0 1.4 1 1 0 1 1 1 0 Septin Sec23_trunk PF04811.13 NM_004922.3_1 - 1.7e-91 306.0 0.1 2.5e-91 305.5 0.1 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.13 NM_004922.3_1 - 4.5e-27 93.7 0.1 8.7e-27 92.8 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.10 NM_004922.3_1 - 2e-17 63.6 0.0 8.5e-17 61.5 0.0 2.1 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.13 NM_004922.3_1 - 7.4e-14 51.4 12.2 1.8e-13 50.1 12.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 NM_004922.3_1 - 4.2e-12 45.7 0.0 9.2e-12 44.6 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Y_phosphatase PF00102.25 NM_002842.4_2 - 1.8e-77 259.9 0.0 4.9e-77 258.5 0.0 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase fn3 PF00041.19 NM_002842.4_2 - 4.7e-57 190.2 42.7 7.2e-09 35.7 4.3 8.0 8 0 0 8 8 8 7 Fibronectin type III domain DUF2369 PF10179.7 NM_002842.4_2 - 1.2e-14 54.4 2.4 1.3 9.4 0.0 7.5 7 0 0 7 7 7 4 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.3 NM_002842.4_2 - 2.7e-10 40.5 49.5 0.13 12.7 3.6 8.7 5 4 1 6 6 6 5 Purple acid Phosphatase, N-terminal domain SusE PF14292.4 NM_002842.4_2 - 1.1e-08 35.3 23.0 0.87 9.9 0.1 7.2 6 1 1 7 7 7 4 SusE outer membrane protein Interfer-bind PF09294.8 NM_002842.4_2 - 4.8e-08 33.1 0.4 0.83 9.9 0.0 6.6 7 0 0 7 7 7 1 Interferon-alpha/beta receptor, fibronectin type III CBM_4_9 PF02018.15 NM_002842.4_2 - 1.9e-05 24.8 20.8 0.25 11.4 0.3 6.9 4 1 2 7 7 7 2 Carbohydrate binding domain Y_phosphatase3 PF13350.4 NM_002842.4_2 - 0.0035 17.2 0.0 0.0058 16.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 NM_002842.4_2 - 0.012 15.3 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Lipoprotein_21 PF14041.4 NM_002842.4_2 - 0.026 14.5 6.7 6.4 6.8 0.2 4.6 4 0 0 4 4 4 0 LppP/LprE lipoprotein Syndecan PF01034.18 NM_002842.4_2 - 0.028 14.2 0.5 0.054 13.3 0.5 1.3 1 0 0 1 1 1 0 Syndecan domain EphA2_TM PF14575.4 NM_002842.4_2 - 0.031 14.9 0.0 0.063 14.0 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PTPlike_phytase PF14566.4 NM_002842.4_2 - 0.14 12.1 0.0 0.62 10.1 0.0 2.0 2 0 0 2 2 2 0 Inositol hexakisphosphate DUF4945 PF16303.3 NM_002842.4_2 - 0.24 11.2 11.2 41 4.0 0.0 6.0 7 0 0 7 7 7 0 Domain of unknown function (DUF4945) DUF2207 PF09972.7 NM_002842.4_2 - 0.44 9.1 7.8 7.6 5.0 0.0 3.6 4 0 0 4 4 4 0 Predicted membrane protein (DUF2207) Pkinase PF00069.23 NM_172216.1_2 - 2.6e-61 207.2 0.0 7.3e-61 205.7 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_172216.1_2 - 4.1e-32 111.4 0.0 1.1e-30 106.7 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_172216.1_2 - 6.2e-07 28.9 0.0 8.9e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SRP40_C PF05022.10 NM_172216.1_2 - 0.12 13.1 0.8 0.33 11.7 0.8 1.7 1 0 0 1 1 1 0 SRP40, C-terminal domain zf-C4 PF00105.16 NM_001278546.1_3 - 1.6e-27 95.6 18.1 1.6e-27 95.6 18.1 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001278546.1_3 - 2.8e-18 66.2 4.1 4.6e-18 65.4 4.1 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor AAA_34 PF13872.4 NM_018183.3_1 - 3.5e-141 469.3 0.0 5.1e-141 468.8 0.0 1.2 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.4 NM_018183.3_1 - 8.7e-123 409.0 0.1 1.2e-122 408.6 0.1 1.2 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue ResIII PF04851.13 NM_018183.3_1 - 3.7e-07 30.2 0.0 1.2e-06 28.6 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Reo_sigmaC PF04582.10 NM_001164541.1_3 - 0.3 10.3 1.0 0.42 9.8 0.2 1.8 2 0 0 2 2 2 0 Reovirus sigma C capsid protein ADIP PF11559.6 NM_001164541.1_3 - 0.55 10.2 23.4 0.43 10.5 3.1 4.3 4 0 0 4 4 4 0 Afadin- and alpha -actinin-Binding Macoilin PF09726.7 NM_001164541.1_3 - 1.5 7.1 11.0 0.076 11.4 5.3 1.6 2 0 0 2 2 2 0 Transmembrane protein TPR_MLP1_2 PF07926.10 NM_001164541.1_3 - 9.5 6.2 21.0 2.8 7.9 3.8 4.2 3 1 2 5 5 5 0 TPR/MLP1/MLP2-like protein AIG1 PF04548.14 NM_001199577.1_3 - 1.9e-122 406.3 0.0 8.9e-79 263.6 0.0 2.1 2 0 0 2 2 2 2 AIG1 family MMR_HSR1 PF01926.21 NM_001199577.1_3 - 3.7e-15 55.9 0.0 1.1e-07 31.8 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase ABC_tran PF00005.25 NM_001199577.1_3 - 7.3e-05 23.2 0.1 0.62 10.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter DUF258 PF03193.14 NM_001199577.1_3 - 0.00027 20.8 0.5 0.53 10.0 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 FeoB_N PF02421.16 NM_001199577.1_3 - 0.00027 20.4 0.0 0.66 9.4 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B AAA_22 PF13401.4 NM_001199577.1_3 - 0.00088 19.4 0.5 0.68 10.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.21 NM_001199577.1_3 - 0.0041 17.1 4.6 1.4 8.8 0.3 3.2 2 2 1 3 3 3 2 Dynamin family Zeta_toxin PF06414.10 NM_001199577.1_3 - 0.02 14.1 0.2 4.4 6.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.20 NM_001199577.1_3 - 0.047 13.9 0.0 2.5 8.4 0.0 2.3 2 0 0 2 2 2 0 RNA helicase DUF815 PF05673.11 NM_001199577.1_3 - 0.064 12.3 0.1 2.4 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_29 PF13555.4 NM_001199577.1_3 - 0.11 12.1 1.5 7.5 6.2 0.0 2.8 3 0 0 3 3 3 0 P-loop containing region of AAA domain DAP3 PF10236.7 NM_001199577.1_3 - 0.14 11.1 0.1 11 4.9 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 T2SSE PF00437.18 NM_001199577.1_3 - 0.18 10.7 0.5 17 4.2 0.1 2.5 3 0 0 3 3 3 0 Type II/IV secretion system protein Septin PF00735.16 NM_001199577.1_3 - 0.18 10.9 0.0 2.4 7.2 0.0 2.2 2 0 0 2 2 2 0 Septin PduV-EutP PF10662.7 NM_001199577.1_3 - 0.19 11.4 0.5 5.8 6.5 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.27 NM_001199577.1_3 - 0.2 12.0 0.6 5.7 7.2 0.0 2.8 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.15 NM_001199577.1_3 - 3 7.7 5.5 9.3 6.1 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function DUF87 Mg_trans_NIPA PF05653.12 NM_001184888.1_1 - 1.1e-126 421.8 19.6 4.3e-125 416.6 19.6 2.1 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.18 NM_001184888.1_1 - 3.7e-06 27.0 5.7 3.7e-06 27.0 5.7 3.9 3 1 0 3 3 3 1 EamA-like transporter family RRM_1 PF00076.20 NM_001122825.1_1 - 3.5e-14 52.2 0.0 0.0019 17.9 0.0 3.7 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CC2-LZ PF16516.3 NM_001252392.1_1 - 3.6e-07 30.3 21.8 3.6e-07 30.3 21.8 5.8 4 1 1 5 5 5 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF4407 PF14362.4 NM_001252392.1_1 - 1 8.5 48.2 23 4.1 35.4 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.10 NM_001252392.1_1 - 6.2 7.2 18.1 4.2 7.8 0.7 4.5 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein ubiquitin PF00240.21 NM_001128324.2_1 - 5e-17 61.3 0.0 9e-17 60.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family zf-AN1 PF01428.14 NM_001128324.2_1 - 5.5e-09 35.9 8.3 1.6e-08 34.4 8.3 1.9 1 0 0 1 1 1 1 AN1-like Zinc finger Rad60-SLD PF11976.6 NM_001128324.2_1 - 0.0003 20.4 0.0 0.00065 19.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 NM_001128324.2_1 - 0.033 14.5 0.0 0.11 12.9 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-like domain FKBP_C PF00254.26 NM_007270.4_3 - 8.9e-112 365.6 0.0 3.2e-27 94.6 0.0 4.8 5 0 0 5 5 5 4 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_1 PF00036.30 NM_007270.4_3 - 1.8e-09 36.3 1.3 0.00079 18.7 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.4 NM_007270.4_3 - 6.1e-06 25.4 0.7 0.0084 15.5 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_007270.4_3 - 1.9e-05 24.1 0.3 0.15 12.0 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.4 NM_007270.4_3 - 2.7e-05 24.4 0.3 0.00012 22.3 0.3 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 NM_007270.4_3 - 0.0016 18.0 0.2 0.99 9.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair Adaptin_N PF01602.18 NM_145730.2_2 - 2.6e-164 547.5 15.1 3.4e-164 547.2 15.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 NM_145730.2_2 - 1.7e-67 226.3 12.8 1.4e-65 220.1 1.4 3.5 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.8 NM_145730.2_2 - 3e-37 127.0 0.0 7.1e-37 125.8 0.0 1.7 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.4 NM_145730.2_2 - 9e-22 77.1 3.5 3.7e-08 33.5 0.0 5.9 3 2 4 7 7 7 6 HEAT repeats HEAT PF02985.20 NM_145730.2_2 - 7.4e-12 44.3 8.7 0.0095 16.0 0.1 7.0 7 0 0 7 7 7 3 HEAT repeat Alpha_adaptinC2 PF02883.18 NM_145730.2_2 - 5.3e-09 36.2 1.5 7.2e-09 35.8 0.4 1.9 2 0 0 2 2 1 1 Adaptin C-terminal domain Cnd3 PF12719.5 NM_145730.2_2 - 6.3e-09 35.3 4.5 1.8e-05 24.0 0.3 2.5 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain Arm PF00514.21 NM_145730.2_2 - 2.9e-06 27.0 4.4 0.018 14.9 0.0 5.1 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.7 NM_145730.2_2 - 0.00015 21.8 6.4 0.099 12.7 0.0 5.0 2 2 1 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.6 NM_145730.2_2 - 0.00021 20.8 1.6 0.94 8.9 0.1 4.0 2 2 0 2 2 2 2 CLASP N terminal Arm_2 PF04826.11 NM_145730.2_2 - 0.014 14.8 0.1 0.042 13.2 0.1 1.8 1 0 0 1 1 1 0 Armadillo-like Cohesin_HEAT PF12765.5 NM_145730.2_2 - 0.041 14.0 0.0 36 4.6 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion UNC45-central PF11701.6 NM_145730.2_2 - 0.053 13.3 0.4 2.4 8.0 0.0 3.1 3 1 0 3 3 3 0 Myosin-binding striated muscle assembly central HEAT_EZ PF13513.4 NM_145730.2_2 - 0.067 13.5 7.0 9.5 6.7 0.0 5.6 7 0 0 7 7 7 0 HEAT-like repeat Sec7_N PF12783.5 NM_145730.2_2 - 0.75 9.6 5.3 0.51 10.2 0.4 3.0 3 1 2 5 5 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal YAF2_RYBP PF17219.1 NM_005748.5_3 - 3.3e-18 64.7 0.2 5.8e-18 63.9 0.2 1.4 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif zf-RanBP PF00641.16 NM_005748.5_3 - 8.6e-08 31.2 2.0 2.2e-07 29.9 2.0 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others SH3-WW_linker PF16618.3 NM_001270695.1_2 - 3.1e-73 246.4 10.8 8.7e-73 244.9 10.8 1.8 1 0 0 1 1 1 1 Linker region between SH3 and WW domains on ARHGAP12 RhoGAP PF00620.25 NM_001270695.1_2 - 4.7e-50 169.2 0.0 8.3e-50 168.4 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 NM_001270695.1_2 - 3.1e-10 40.4 0.5 3.1e-10 40.4 0.5 2.3 2 0 0 2 2 2 1 PH domain SH3_9 PF14604.4 NM_001270695.1_2 - 4.4e-09 35.9 0.3 9e-09 34.9 0.3 1.6 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.24 NM_001270695.1_2 - 4.8e-07 29.5 15.4 9.6e-06 25.3 4.4 3.5 3 0 0 3 3 3 2 WW domain PH_9 PF15410.4 NM_001270695.1_2 - 1.6e-06 28.3 0.5 3.3e-06 27.3 0.5 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_1 PF00018.26 NM_001270695.1_2 - 4.7e-05 22.8 2.4 8.8e-05 21.9 0.6 2.3 2 0 0 2 2 2 1 SH3 domain DUF2255 PF10012.7 NM_001270695.1_2 - 0.055 13.5 0.3 0.37 10.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2255) IL6Ra-bind PF09240.8 NM_181359.2_3 - 8e-18 64.5 0.8 1.4e-17 63.7 0.8 1.4 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding ig PF00047.23 NM_181359.2_3 - 1.1e-05 25.3 0.0 2.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_181359.2_3 - 6.4e-05 23.4 0.2 0.0002 21.8 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 NM_181359.2_3 - 0.0011 19.1 0.0 0.0036 17.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.19 NM_181359.2_3 - 0.016 15.4 0.2 0.028 14.6 0.2 1.4 1 0 0 1 1 1 0 Fibronectin type III domain Ig_3 PF13927.4 NM_181780.3_3 - 3.6e-06 27.4 0.1 7.1e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 NM_181780.3_3 - 5.2e-05 23.2 0.4 0.00011 22.1 0.4 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 NM_181780.3_3 - 0.00016 21.7 0.2 0.00055 19.9 0.2 1.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 NM_181780.3_3 - 0.00078 19.3 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_181780.3_3 - 0.0012 19.1 0.3 0.0028 17.8 0.3 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_4 PF12799.5 NM_012403.1_1 - 8.3e-12 45.0 14.0 1.4e-08 34.7 4.5 3.1 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_012403.1_1 - 2.6e-11 43.2 0.8 1.2e-10 41.1 0.7 1.8 1 1 1 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.4 NM_012403.1_1 - 1.3e-05 24.7 14.0 0.00017 21.1 1.7 2.8 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.4 NM_012403.1_1 - 0.0019 18.0 6.5 0.035 14.0 0.1 3.3 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.31 NM_012403.1_1 - 0.014 15.6 3.8 1.7 9.3 0.1 3.3 3 0 0 3 3 3 0 Leucine Rich Repeat Staufen_C PF16482.3 NM_012403.1_1 - 0.14 12.1 0.0 19 5.3 0.0 2.1 2 0 0 2 2 2 0 Staufen C-terminal domain CobT PF06213.10 NM_012403.1_1 - 1.2 8.3 15.2 1.7 7.9 15.2 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SDA1 PF05285.10 NM_012403.1_1 - 4.2 6.6 19.3 4.8 6.4 19.3 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.10 NM_012403.1_1 - 9 4.2 22.9 11 4.0 22.9 1.1 1 0 0 1 1 1 0 Nop14-like family LRR_8 PF13855.4 NM_001040021.2_2 - 8e-08 31.8 0.4 0.0013 18.3 0.0 3.8 4 0 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.5 NM_001040021.2_2 - 8.5e-08 32.2 2.6 0.014 15.6 0.0 4.2 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 NM_001040021.2_2 - 0.00034 20.3 7.4 0.85 9.7 0.0 5.0 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.31 NM_001040021.2_2 - 0.0013 18.7 5.7 11 6.8 0.6 4.8 4 2 0 4 4 4 2 Leucine Rich Repeat ORC3_N PF07034.9 NM_012381.3_1 - 1.9e-132 441.3 7.5 1.9e-132 441.3 7.5 1.5 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus Aldedh PF00171.20 NM_170726.2_1 - 6.1e-104 348.0 0.0 7.5e-104 347.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Lipase_GDSL PF00657.20 NM_001177507.1_3 - 1.7e-24 86.8 0.0 2.4e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SapB_2 PF03489.15 NM_001177507.1_3 - 1.2e-06 28.4 3.3 1.2e-06 28.3 0.4 2.5 2 0 0 2 2 2 1 Saposin-like type B, region 2 Lipase_GDSL_2 PF13472.4 NM_001177507.1_3 - 0.012 15.9 0.0 0.032 14.5 0.0 1.7 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Cu-binding_MopE PF11617.6 NM_001177507.1_3 - 0.012 15.7 4.6 0.049 13.7 4.6 2.1 1 1 0 1 1 1 0 Putative metal-binding motif BTB_2 PF02214.20 NM_024076.2_2 - 2.2e-15 56.6 0.1 3.5e-15 56.0 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain GDA1_CD39 PF01150.15 NM_001322396.1_1 - 6.3e-60 202.9 0.0 8.5e-60 202.5 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family GDA1_CD39 PF01150.15 NM_001322396.1_2 - 2.1e-05 23.3 0.0 3e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family MAPEG PF01124.16 NM_001629.3_3 - 1.6e-08 34.4 2.0 2.4e-08 33.8 2.0 1.3 1 0 0 1 1 1 1 MAPEG family Methyltransf_5 PF01795.17 NM_152636.2_2 - 1.7e-25 90.1 0.1 3.8e-25 88.9 0.1 1.5 1 1 0 1 1 1 1 MraW methylase family Methyltransf_5 PF01795.17 NM_152636.2_3 - 1.6e-56 191.9 0.0 2.3e-56 191.4 0.0 1.1 1 0 0 1 1 1 1 MraW methylase family Methyltr_RsmB-F PF01189.15 NM_152636.2_3 - 0.00031 20.3 0.0 0.00045 19.8 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F SPRR2 PF14820.4 NM_001024209.3_2 - 1.2e-23 83.0 80.4 1.2e-23 83.0 80.4 2.1 2 0 0 2 2 2 1 Small proline-rich 2 Lon_C PF05362.11 NM_031490.3_1 - 2.8e-80 268.6 0.0 4.2e-80 268.0 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.14 NM_031490.3_1 - 4.7e-22 78.8 0.1 8.7e-22 77.9 0.1 1.5 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.27 NM_031490.3_1 - 1.2e-20 74.1 0.0 2.3e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 NM_031490.3_1 - 4.2e-08 33.2 0.0 7.4e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.4 NM_031490.3_1 - 6e-05 22.7 0.0 0.00012 21.8 0.0 1.5 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.4 NM_031490.3_1 - 0.00051 20.3 0.0 0.0013 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_3 PF07726.9 NM_031490.3_1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.12 NM_031490.3_1 - 0.0043 17.0 0.0 0.009 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.4 NM_031490.3_1 - 0.0072 16.5 0.0 0.036 14.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_PrkA PF08298.9 NM_031490.3_1 - 0.011 14.5 0.0 0.07 11.9 0.0 2.0 2 0 0 2 2 2 0 PrkA AAA domain DUF258 PF03193.14 NM_031490.3_1 - 0.03 14.1 0.0 0.055 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 TIP49 PF06068.11 NM_031490.3_1 - 0.035 12.9 0.1 4.9 5.9 0.0 2.3 2 0 0 2 2 2 0 TIP49 C-terminus AAA_18 PF13238.4 NM_031490.3_1 - 0.049 14.0 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.10 NM_031490.3_1 - 0.052 12.7 0.0 0.16 11.1 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus SKI PF01202.20 NM_031490.3_1 - 0.091 12.7 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 Shikimate kinase NACHT PF05729.10 NM_031490.3_1 - 0.11 12.3 0.9 27 4.5 0.3 3.3 3 0 0 3 3 3 0 NACHT domain IstB_IS21 PF01695.15 NM_031490.3_1 - 0.16 11.6 0.1 0.47 10.1 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_33 PF13671.4 NM_031490.3_1 - 0.22 11.5 0.8 0.31 11.1 0.0 1.6 2 0 0 2 2 1 0 AAA domain MAP7 PF05672.9 NM_001198619.1_1 - 7.3e-41 139.5 83.3 7.3e-41 139.5 83.3 2.5 2 0 0 2 2 2 1 MAP7 (E-MAP-115) family EF-hand_4 PF12763.5 NM_001163545.2_3 - 0.025 14.4 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Ras PF00071.20 NM_001278368.1_2 - 6.1e-44 149.3 0.0 8e-44 149.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001278368.1_2 - 1e-21 77.2 0.0 1.5e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001278368.1_2 - 4.3e-07 29.4 0.0 6e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001278368.1_2 - 0.044 13.8 0.0 0.067 13.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase DAGK_cat PF00781.22 NM_021972.3_3 - 7.3e-28 96.6 0.0 1.1e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain EVC2_like PF12297.6 NM_147127.4_1 - 2.8e-199 662.1 23.2 2.8e-199 662.1 23.2 4.3 3 1 2 5 5 5 1 Ellis van Creveld protein 2 like protein HBS1_N PF08938.8 NM_147127.4_1 - 0.35 11.1 2.6 2 8.6 2.6 2.4 1 0 0 1 1 1 0 HBS1 N-terminus fn3 PF00041.19 NM_022823.2_2 - 1.2e-11 44.6 0.2 2.2e-11 43.8 0.2 1.4 1 0 0 1 1 1 1 Fibronectin type III domain DUF4808 PF16066.3 NM_022823.2_2 - 0.0012 19.4 0.1 0.0026 18.3 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4808) NPIP PF06409.9 NM_001310136.1_1 - 1.8e-112 374.8 41.6 1.9e-57 194.4 3.6 6.2 1 1 5 6 6 6 6 Nuclear pore complex interacting protein (NPIP) AT_hook PF02178.17 NM_001310136.1_2 - 4.5 7.3 10.6 3 7.9 2.9 2.9 2 0 0 2 2 2 0 AT hook motif NO_synthase PF02898.13 NM_001160111.1_1 - 2.2e-181 602.6 0.0 2.7e-181 602.3 0.0 1.1 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain Flavodoxin_1 PF00258.23 NM_001160111.1_1 - 3.5e-23 82.3 0.0 5.9e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin Pkinase_Tyr PF07714.15 NM_001253357.1_2 - 5.4e-91 304.3 0.0 7.1e-91 303.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001253357.1_2 - 5.2e-40 137.3 0.0 7.8e-40 136.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 NM_001253357.1_2 - 6.4e-38 128.9 0.1 2.5e-13 50.1 0.0 3.4 3 0 0 3 3 3 3 Fibronectin type III domain ig PF00047.23 NM_001253357.1_2 - 8.1e-16 57.8 0.0 3e-08 33.6 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_001253357.1_2 - 3.7e-07 30.0 0.0 0.026 14.4 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001253357.1_2 - 3.3e-06 27.5 0.0 0.048 14.2 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 NM_001253357.1_2 - 2e-05 24.9 0.0 9 6.8 0.0 4.0 3 1 0 3 3 3 3 Purple acid Phosphatase, N-terminal domain Ig_2 PF13895.4 NM_001253357.1_2 - 0.00032 20.9 0.0 0.091 13.0 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain EGF_2 PF07974.11 NM_001253357.1_2 - 0.00096 19.3 14.2 0.00096 19.3 14.2 5.3 4 1 0 4 4 3 2 EGF-like domain hEGF PF12661.5 NM_001253357.1_2 - 0.0019 18.7 7.6 0.0019 18.7 7.6 4.1 3 0 0 3 3 2 2 Human growth factor-like EGF C2-set PF05790.13 NM_001253357.1_2 - 0.057 13.5 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin C2-set domain Laminin_EGF PF00053.22 NM_001253357.1_2 - 0.31 11.1 50.4 0.36 10.9 17.9 3.9 1 1 2 3 3 3 0 Laminin EGF domain BAT2_N PF07001.9 NM_080686.2_1 - 7.3e-71 238.5 10.6 7.3e-71 238.5 10.6 4.8 4 1 1 5 5 5 1 BAT2 N-terminus Amelogenin PF02948.13 NM_001142.2_3 - 2.5e-70 236.5 56.8 3e-70 236.2 56.8 1.1 1 0 0 1 1 1 1 Amelogenin RhoGEF PF00621.18 NM_001320276.1_3 - 3.5e-27 95.7 0.1 6.8e-27 94.7 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.19 NM_001320276.1_3 - 1.6e-13 50.5 10.3 1.6e-13 50.5 10.3 2.6 2 0 0 2 2 2 1 FYVE zinc finger PH PF00169.27 NM_001320276.1_3 - 1.4e-09 38.3 0.0 1.9e-07 31.4 0.0 2.8 2 0 0 2 2 2 1 PH domain PH_13 PF16652.3 NM_001320276.1_3 - 6.5e-05 22.7 0.4 0.3 10.8 0.2 2.9 2 1 0 2 2 2 2 Pleckstrin homology domain Peptidase_S48 PF03574.13 NM_001320276.1_3 - 0.054 13.6 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Peptidase family S48 MitMem_reg PF13012.4 NM_001320276.1_3 - 0.073 13.4 0.4 0.93 9.8 0.1 2.4 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function FYVE_2 PF02318.14 NM_001320276.1_3 - 0.17 12.0 8.6 0.57 10.3 8.6 1.9 1 0 0 1 1 1 0 FYVE-type zinc finger Cadherin PF00028.15 NM_001171931.1_1 - 1.1e-151 493.7 10.3 6.8e-20 71.2 0.0 10.1 10 0 0 10 10 10 10 Cadherin domain Cadherin_2 PF08266.10 NM_001171931.1_1 - 3.8e-11 42.5 0.0 0.72 9.6 0.0 6.5 6 0 0 6 6 6 4 Cadherin-like Cadherin_3 PF16184.3 NM_001171931.1_1 - 1.6e-10 40.8 10.8 0.0023 17.8 0.0 8.2 9 0 0 9 9 9 4 Cadherin-like Atg8 PF02991.14 NM_032514.3_2 - 8.5e-43 144.7 0.3 1.2e-42 144.2 0.3 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 NM_032514.3_2 - 3.6e-05 23.9 0.0 5.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 TSGP1 PF07771.9 NM_032514.3_2 - 7.7 6.6 11.5 13 5.8 11.5 1.3 1 0 0 1 1 1 0 Tick salivary peptide group 1 AP3D1 PF06375.9 NM_032514.3_2 - 8.2 6.6 14.4 14 5.8 14.4 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Adaptin_N PF01602.18 NM_001128.5_3 - 1e-155 519.1 7.7 1.3e-155 518.8 7.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.18 NM_001128.5_3 - 1.3e-33 115.4 5.2 2.1e-33 114.8 5.2 1.3 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.5 NM_001128.5_3 - 2.9e-12 46.7 3.5 3.6e-09 36.7 0.3 2.8 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 CD225 PF04505.10 NM_001098825.1_1 - 4e-08 33.1 0.7 7e-08 32.4 0.7 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein AdoHcyase PF05221.15 NM_015328.3_1 - 1.1e-121 405.4 0.0 4.8e-65 219.5 0.1 2.1 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.19 NM_015328.3_1 - 7.2e-81 269.9 2.1 1.1e-80 269.3 2.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.17 NM_015328.3_1 - 9.3e-09 34.7 0.1 1.9e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.17 NM_015328.3_1 - 0.0011 18.2 0.6 0.0027 16.9 0.6 1.5 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.18 NM_015328.3_1 - 0.0016 18.4 0.1 0.0036 17.2 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.10 NM_015328.3_1 - 0.0023 17.4 0.0 0.004 16.6 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.4 NM_015328.3_1 - 0.023 15.0 0.4 0.05 13.9 0.4 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.16 NM_015328.3_1 - 0.042 14.0 0.1 0.1 12.8 0.1 1.6 1 1 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.19 NM_015328.3_1 - 0.068 12.3 0.5 0.15 11.2 0.5 1.5 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SR-25 PF10500.7 NM_015328.3_1 - 0.5 9.8 12.0 0.8 9.1 12.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein E1-E2_ATPase PF00122.18 NM_005173.3_3 - 7.3e-65 218.2 1.2 7.3e-65 218.2 1.2 2.2 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 NM_005173.3_3 - 3.4e-46 157.1 4.5 7e-46 156.1 4.5 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 NM_005173.3_3 - 1.3e-20 73.2 0.1 2e-20 72.5 0.1 1.3 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 NM_005173.3_3 - 9.1e-20 71.7 0.2 1.2e-18 68.0 0.2 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 NM_005173.3_3 - 4.4e-18 64.6 0.9 7.3e-18 63.9 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 NM_005173.3_3 - 3.1e-06 27.0 1.1 3.1e-06 27.0 1.1 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 NM_005173.3_3 - 0.001 19.4 0.1 0.0029 17.9 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3106 PF11304.6 NM_005173.3_3 - 0.022 15.1 0.0 0.15 12.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) SH2 PF00017.22 NM_014395.2_1 - 1.3e-18 66.7 0.3 2.4e-18 65.8 0.3 1.5 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 NM_014395.2_1 - 1.4e-16 60.7 0.5 2.9e-16 59.8 0.5 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_014395.2_1 - 0.0023 18.2 1.2 0.0078 16.5 1.2 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain CP2 PF04516.13 NM_001173453.1_2 - 3e-29 101.8 0.4 8.9e-26 90.5 0.0 2.2 1 1 1 2 2 2 2 CP2 transcription factor DUF2967 PF11179.6 NM_001173453.1_2 - 1.1 8.5 3.5 1.7 7.9 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) GDA1_CD39 PF01150.15 NM_004901.4_3 - 9.9e-106 353.8 0.0 1.4e-105 353.3 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family RhoGEF PF00621.18 NM_001111270.2_2 - 2.5e-37 128.7 0.2 2.5e-37 128.7 0.2 1.4 2 0 0 2 2 2 1 RhoGEF domain PH_10 PF15411.4 NM_001111270.2_2 - 0.029 14.5 0.0 0.083 13.0 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain PH PF00169.27 NM_001111270.2_2 - 0.086 13.2 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 PH domain SH3-RhoG_link PF16609.3 NM_001111270.2_2 - 3.3 7.2 6.0 0.3 10.7 1.5 1.5 2 0 0 2 2 2 0 SH3-RhoGEF linking unstructured region AbLIM_anchor PF16182.3 NM_001114139.3_3 - 7.8e-78 262.7 13.0 3.1e-57 195.0 9.3 2.1 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 NM_001114139.3_3 - 1.2e-14 53.9 0.8 2.2e-14 53.1 0.8 1.5 1 0 0 1 1 1 1 Villin headpiece domain STAT1_TAZ2bind PF12162.6 NM_001114139.3_3 - 0.048 13.1 0.8 6.5 6.3 0.0 2.7 2 0 0 2 2 2 0 STAT1 TAZ2 binding domain Oxysterol_BP PF01237.16 NM_145638.2_2 - 3.8e-94 315.4 0.6 7.3e-92 307.9 0.6 2.2 1 1 0 1 1 1 1 Oxysterol-binding protein Jiv90 PF14901.4 NM_032364.5_1 - 1.2e-36 124.6 0.3 2.5e-36 123.6 0.3 1.5 1 0 0 1 1 1 1 Cleavage inducing molecular chaperone DnaJ PF00226.29 NM_032364.5_1 - 1.3e-19 70.0 0.1 2.1e-19 69.2 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain SOCS_box PF07525.14 NM_001270467.1_1 - 1.4e-12 47.5 0.1 3.9e-12 46.2 0.1 1.8 1 0 0 1 1 1 1 SOCS box SH2 PF00017.22 NM_001270467.1_1 - 9.5e-11 41.5 0.0 1.5e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.4 NM_001270467.1_1 - 0.011 15.0 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 SH2 domain TRAP-delta PF05404.10 NM_001204527.1_1 - 2.8e-67 225.1 0.0 3.8e-67 224.7 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) Axin_b-cat_bind PF08833.8 NM_001204527.1_2 - 1.5 8.9 4.4 41 4.3 2.8 2.8 2 1 0 2 2 2 0 Axin beta-catenin binding domain Exo_endo_phos PF03372.21 NM_001009934.2_1 - 2.7e-07 30.7 0.0 4.1e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Hemagglutinin PF00509.16 NM_001009934.2_1 - 0.15 10.3 0.1 0.25 9.6 0.1 1.2 1 0 0 1 1 1 0 Haemagglutinin Peptidase_M10 PF00413.22 NM_002429.5_1 - 6.8e-48 162.4 0.0 9.6e-48 161.9 0.0 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 NM_002429.5_1 - 1.3e-35 120.9 10.2 4.2e-13 48.9 0.1 4.6 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 NM_002429.5_1 - 4.9e-08 32.9 0.0 8.9e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain DUF4953 PF16313.3 NM_002429.5_1 - 0.0061 15.7 0.2 0.0089 15.1 0.2 1.1 1 0 0 1 1 1 1 Met-zincin Reprolysin_3 PF13582.4 NM_002429.5_1 - 0.017 15.5 0.0 0.03 14.7 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.22 NM_002429.5_1 - 0.026 14.0 0.0 2.2 7.7 0.1 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M66 PF10462.7 NM_002429.5_1 - 0.043 12.6 0.1 0.068 12.0 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_4 PF13583.4 NM_002429.5_1 - 0.12 11.9 0.1 0.2 11.2 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like RNA_pol_Rpo13 PF12136.6 NM_002429.5_1 - 2.5 8.0 4.8 4.6 7.1 4.8 1.4 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain Leuk-A4-hydro_C PF09127.9 NM_001193329.1_1 - 3.2e-26 91.9 2.9 3.2e-26 91.9 2.9 1.7 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1 PF01433.18 NM_001193329.1_1 - 2.7e-24 86.1 0.0 1.2e-12 47.8 0.0 3.0 3 0 0 3 3 3 2 Peptidase family M1 DUF4380 PF14315.4 NM_001193329.1_2 - 0.15 10.8 0.2 0.23 10.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4380) Homeobox PF00046.27 NM_177400.2_2 - 3.6e-21 74.6 1.0 5.4e-21 74.0 1.0 1.3 1 0 0 1 1 1 1 Homeobox domain NCOA_u2 PF16665.3 NM_177400.2_2 - 0.16 12.2 0.4 16 5.7 0.1 2.7 2 0 0 2 2 2 0 Unstructured region on nuclear receptor coactivator protein Homez PF11569.6 NM_177400.2_2 - 0.16 11.3 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez MAGE_N PF12440.6 NM_001011549.1_3 - 7.1e-25 87.4 13.6 1.4e-24 86.4 13.6 1.5 1 0 0 1 1 1 1 Melanoma associated antigen family N terminal MAGE PF01454.17 NM_001011549.1_3 - 2.9e-14 53.1 0.0 5.9e-12 45.6 0.0 2.2 1 1 0 1 1 1 1 MAGE family DUF3098 PF11297.6 NM_001011549.1_3 - 0.055 12.9 0.1 0.098 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) ANAPC10 PF03256.14 NM_001256710.1_1 - 8.6e-23 80.8 0.0 1.3e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) ANAPC10 PF03256.14 NM_001256710.1_2 - 1e-50 171.9 0.0 1.5e-50 171.3 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.23 NM_001256710.1_2 - 0.0094 15.9 0.0 0.014 15.3 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain 7tm_4 PF13853.4 NM_001005193.1_1 - 6.1e-56 190.1 20.3 8.3e-56 189.6 20.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005193.1_1 - 1.6e-23 83.2 22.7 3.8e-23 81.9 22.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001005193.1_1 - 2.1e-05 23.9 19.0 3.7e-05 23.1 19.0 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx MARCKS PF02063.15 NM_002356.6_1 - 9.5e-95 317.7 140.5 2.1e-94 316.5 140.5 1.5 1 1 0 1 1 1 1 MARCKS family Paxillin PF03535.11 NM_025157.4_3 - 4.2e-93 310.7 18.8 6.9e-93 310.0 18.8 1.3 1 0 0 1 1 1 1 Paxillin family LIM PF00412.20 NM_025157.4_3 - 4.9e-65 215.5 37.7 8.2e-18 64.3 2.1 4.3 4 0 0 4 4 4 4 LIM domain V-set PF07686.15 NM_001008228.2_2 - 8.5e-11 41.8 0.0 1.4e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001008228.2_2 - 6.7e-05 23.3 0.0 0.00026 21.4 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_001008228.2_2 - 0.00013 21.8 0.0 0.00035 20.5 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_001008228.2_2 - 0.00076 19.5 0.0 0.0069 16.4 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin domain EGF_CA PF07645.13 NM_022486.4_3 - 8.3e-17 61.0 38.9 1.2e-09 38.0 4.6 4.3 4 0 0 4 4 4 2 Calcium-binding EGF domain Sushi PF00084.18 NM_022486.4_3 - 1e-11 45.1 5.9 1.6e-06 28.5 0.9 5.1 5 1 0 5 5 5 2 Sushi repeat (SCR repeat) EGF_3 PF12947.5 NM_022486.4_3 - 1.2e-07 31.6 33.2 0.00038 20.5 11.1 3.9 3 0 0 3 3 3 3 EGF domain cEGF PF12662.5 NM_022486.4_3 - 2.1e-07 30.6 26.0 6.5e-06 25.9 1.9 5.4 5 0 0 5 5 5 3 Complement Clr-like EGF-like fn3 PF00041.19 NM_022486.4_3 - 2.7e-05 24.3 0.2 0.93 9.8 0.0 4.1 4 0 0 4 4 4 1 Fibronectin type III domain EGF PF00008.25 NM_022486.4_3 - 0.0029 17.7 39.9 0.063 13.5 8.9 4.2 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.5 NM_022486.4_3 - 0.0056 17.2 47.7 0.0094 16.5 8.9 5.4 6 0 0 6 6 6 3 Human growth factor-like EGF FXa_inhibition PF14670.4 NM_022486.4_3 - 0.02 15.0 29.7 0.02 15.0 6.0 4.0 2 1 1 3 3 3 0 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.5 NM_022486.4_3 - 0.081 12.8 27.1 0.025 14.5 6.6 3.8 3 0 0 3 3 3 0 MSP1 EGF domain 1 NAD_binding_1 PF00175.19 NM_007326.4_3 - 4.9e-36 123.5 0.0 8.5e-36 122.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.22 NM_007326.4_3 - 1.8e-35 121.1 0.0 2.6e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.10 NM_007326.4_3 - 0.00031 20.8 0.0 0.0011 19.0 0.0 1.8 2 0 0 2 2 2 1 Ferric reductase NAD binding domain ArfGap PF01412.16 NM_001198980.1_1 - 3.8e-32 110.6 0.0 3.8e-32 110.6 0.0 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Ets PF00178.20 NM_001257168.1_2 - 2.3e-36 124.0 0.7 3.9e-36 123.2 0.7 1.4 1 0 0 1 1 1 1 Ets-domain SUZ PF12752.5 NM_001114600.2_1 - 6e-13 49.2 0.1 1.9e-12 47.6 0.1 1.9 1 0 0 1 1 1 1 SUZ domain SUZ-C PF12901.5 NM_001114600.2_1 - 4e-09 36.2 3.0 9.6e-09 35.0 3.0 1.7 1 0 0 1 1 1 1 SUZ-C motif Pkinase PF00069.23 NM_001032296.3_3 - 7.6e-71 238.4 0.0 9.6e-71 238.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001032296.3_3 - 3.8e-53 180.3 0.0 5.3e-53 179.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1241 PF06840.9 NM_001032296.3_3 - 0.013 15.0 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) zf-H2C2_2 PF13465.4 NM_001289184.1_2 - 9.2e-78 253.3 89.4 4.4e-09 36.3 0.6 15.2 14 2 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001289184.1_2 - 9.3e-47 154.8 99.2 1.3e-05 25.3 0.3 13.8 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001289184.1_2 - 4.9e-28 95.2 90.8 0.019 15.7 0.3 13.6 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_001289184.1_2 - 2e-22 78.4 0.9 4.1e-22 77.5 0.9 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001289184.1_2 - 2.9e-20 71.6 73.9 0.00046 19.9 0.5 13.6 13 0 0 13 13 13 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001289184.1_2 - 7.1e-08 32.3 47.5 0.027 14.5 3.2 8.4 5 3 5 10 10 10 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001289184.1_2 - 0.00035 20.7 59.6 0.24 11.6 0.4 11.3 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001289184.1_2 - 0.0042 17.0 45.7 6.1 6.8 0.0 10.9 12 0 0 12 12 12 4 XPA protein N-terminal FYVE PF01363.19 NM_001289184.1_2 - 0.0043 17.0 55.6 0.0072 16.3 3.1 6.1 2 2 3 5 5 5 3 FYVE zinc finger zinc_ribbon_15 PF17032.3 NM_001289184.1_2 - 0.24 12.1 46.0 0.27 11.9 1.0 7.2 4 2 4 8 8 8 0 zinc-ribbon family C1_4 PF07975.10 NM_001289184.1_2 - 3.5 7.8 52.7 1.6 8.9 2.2 8.2 2 2 6 9 9 9 0 TFIIH C1-like domain Histone_H2A_C PF16211.3 NM_003509.2_3 - 1.6e-20 72.4 2.4 2.8e-20 71.6 2.4 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 NM_003509.2_3 - 1.5e-16 60.9 0.0 2e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_003509.2_3 - 4.7e-05 23.5 0.0 6.6e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SapB_2 PF03489.15 NM_012483.3_1 - 2.7e-05 24.0 0.0 0.00045 20.2 0.0 2.3 2 0 0 2 2 2 1 Saposin-like type B, region 2 zf-CCCH_3 PF15663.3 NM_001170704.1_3 - 0.00044 20.3 10.0 0.061 13.4 2.3 2.4 2 0 0 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.4 NM_001170704.1_3 - 0.12 12.8 25.1 8.7 6.9 1.8 5.2 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger Atg8 PF02991.14 NM_001004343.2_1 - 3.3e-38 129.9 0.2 4.5e-38 129.5 0.2 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 NM_001004343.2_1 - 0.00054 20.2 0.0 0.00086 19.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 FERM_M PF00373.16 NM_014907.2_3 - 1.7e-18 67.0 0.2 4.2e-18 65.7 0.2 1.7 1 0 0 1 1 1 1 FERM central domain PDZ PF00595.22 NM_014907.2_3 - 1.1e-07 32.0 0.0 3.7e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) FERM_N PF09379.8 NM_014907.2_3 - 0.00025 20.8 0.2 0.0006 19.6 0.2 1.6 1 0 0 1 1 1 1 FERM N-terminal domain FERM_f0 PF16511.3 NM_014907.2_3 - 0.0048 17.0 0.1 0.012 15.8 0.1 1.6 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM DUF1438 PF07270.9 NM_014907.2_3 - 0.0082 16.1 0.1 0.02 14.8 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1438) PET PF06297.12 NM_014583.3_1 - 7.8e-37 125.3 0.1 1.3e-36 124.6 0.1 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 NM_014583.3_1 - 1.2e-19 70.2 21.8 4.8e-11 42.6 2.5 2.9 3 0 0 3 3 3 2 LIM domain Totivirus_coat PF05518.9 NM_001031806.1_2 - 3.4 5.5 8.0 4.7 5.0 8.0 1.0 1 0 0 1 1 1 0 Totivirus coat protein Aldedh PF00171.20 NM_001031806.1_3 - 1.3e-84 284.2 0.0 1.7e-84 283.8 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.12 NM_001031806.1_3 - 0.0019 17.2 0.0 0.0032 16.4 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) PT-HINT PF07591.9 NM_001031806.1_3 - 0.17 12.0 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Pretoxin HINT domain Hormone_recep PF00104.28 NM_001243518.1_2 - 7.2e-32 110.5 0.6 1.3e-31 109.7 0.6 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_001243518.1_2 - 7.2e-30 103.1 12.3 7.2e-30 103.1 12.3 2.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Ldh_1_C PF02866.16 NM_001261385.1_1 - 8e-05 22.5 0.0 0.00011 22.0 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain UEV PF05743.11 NM_001261385.1_2 - 1.6e-43 147.3 0.3 2.5e-43 146.6 0.3 1.3 1 0 0 1 1 1 1 UEV domain Ldh_1_N PF00056.21 NM_001261385.1_2 - 1.3e-19 70.5 0.1 2e-19 69.9 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Sulfatase PF00884.21 NM_000351.5_3 - 2.1e-93 313.0 0.0 3e-93 312.5 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.4 NM_000351.5_3 - 3.2e-42 144.0 1.2 7e-42 142.9 1.2 1.6 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.20 NM_000351.5_3 - 3.1e-07 30.2 0.7 0.01 15.3 0.1 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Myb_DNA-bind_7 PF15963.3 NM_020825.3_1 - 0.011 15.4 0.1 0.021 14.5 0.1 1.3 1 0 0 1 1 1 0 Myb DNA-binding like Myb_DNA-binding PF00249.29 NM_020825.3_1 - 0.037 14.0 0.0 0.093 12.8 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Trypsin_2 PF13365.4 NM_198847.2_3 - 2.6e-14 54.2 0.0 4.6e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.24 NM_198847.2_3 - 0.00013 21.7 0.1 0.00034 20.3 0.0 1.6 2 0 0 2 2 2 1 Trypsin Lipin_mid PF16876.3 NM_198847.2_3 - 0.0053 16.8 0.4 0.44 10.6 0.0 3.0 2 1 1 3 3 3 1 Lipin/Ned1/Smp2 multi-domain protein middle domain UDPGT PF00201.16 NM_001077.3_2 - 2.5e-265 880.8 0.8 3.1e-265 880.5 0.8 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 NM_001077.3_2 - 6.4e-06 26.1 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain dNK PF01712.17 NM_000788.2_1 - 2.2e-77 259.4 1.2 2.9e-77 259.0 1.2 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.4 NM_000788.2_1 - 0.0076 16.6 0.0 0.099 13.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.15 NM_000788.2_1 - 0.01 15.4 0.0 0.18 11.3 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase AAA_33 PF13671.4 NM_000788.2_1 - 0.022 14.8 0.0 0.11 12.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.4 NM_000788.2_1 - 0.062 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain CSD PF00313.20 NM_001042476.2_1 - 3.2e-11 42.8 0.0 6.2e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.9 NM_001042476.2_1 - 0.08 12.5 0.1 0.21 11.1 0.0 1.7 2 0 0 2 2 2 0 Ribonuclease B OB domain DUF4339 PF14237.4 NM_001042476.2_2 - 0.066 12.9 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4339) ICAM_N PF03921.12 NM_000873.3_2 - 4.2e-41 138.4 1.0 7.8e-41 137.5 1.0 1.5 1 0 0 1 1 1 1 Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 PF13895.4 NM_000873.3_2 - 0.058 13.6 0.3 0.25 11.6 0.0 2.1 2 1 0 2 2 2 0 Immunoglobulin domain PBD PF00786.26 NM_001038702.1_3 - 0.00025 21.3 0.2 0.00045 20.4 0.2 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain Lectin_C PF00059.19 NM_001144893.1_2 - 1.7e-21 76.8 4.5 3.1e-21 76.0 4.5 1.4 1 0 0 1 1 1 1 Lectin C-type domain DUF2170 PF09938.7 NM_001144893.1_2 - 0.0029 17.2 0.2 1.3 8.6 0.1 2.9 1 1 2 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2170) Occludin_ELL PF07303.11 NM_001144893.1_2 - 0.0078 16.8 3.1 0.17 12.5 0.4 2.2 1 1 1 2 2 2 1 Occludin homology domain DUF2730 PF10805.6 NM_001144893.1_2 - 0.04 13.9 1.3 5.5 7.0 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Reo_sigmaC PF04582.10 NM_001144893.1_2 - 0.083 12.1 0.1 0.083 12.1 0.1 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Vps5 PF09325.8 NM_001144893.1_2 - 0.37 10.2 3.2 0.54 9.6 3.2 1.1 1 0 0 1 1 1 0 Vps5 C terminal like DUF4763 PF15960.3 NM_001144893.1_2 - 1.5 8.0 7.3 27 3.8 6.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) DUF2408 PF10303.7 NM_001144893.1_2 - 2 8.8 6.2 51 4.3 6.2 3.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) IMD PF08397.9 NM_138383.2_3 - 6.8e-103 342.6 2.2 9.2e-103 342.2 2.2 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain OmpH PF03938.12 NM_138383.2_3 - 0.38 10.6 2.3 0.69 9.8 2.3 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PP1_inhibitor PF05361.10 NM_001130143.1_2 - 8.6e-07 28.9 0.1 1.1e-06 28.5 0.1 1.1 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor PP1_inhibitor PF05361.10 NM_001130143.1_3 - 1.6e-10 41.0 0.2 2.6e-10 40.3 0.2 1.2 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor GTF2I PF02946.12 NM_033001.3_2 - 1.2e-186 605.0 12.3 8.5e-32 108.9 0.0 6.3 6 0 0 6 6 6 6 GTF2I-like repeat PTPLA PF04387.12 NM_001010915.4_2 - 1.1e-33 116.1 14.1 2.8e-33 114.9 14.1 1.7 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Helicase_C PF00271.29 NM_001257175.1_1 - 1.1e-26 93.2 0.0 2.8e-26 91.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 NM_001257175.1_1 - 1.3e-26 93.3 0.0 2.3e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.13 NM_001257175.1_1 - 0.0001 22.2 0.0 0.00018 21.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Kelch_1 PF01344.23 NM_001256574.1_3 - 4.8e-45 150.8 7.5 1.9e-10 40.0 0.1 5.6 5 0 0 5 5 5 5 Kelch motif BTB PF00651.29 NM_001256574.1_3 - 1.2e-28 99.4 0.1 2.4e-28 98.5 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 NM_001256574.1_3 - 2.3e-28 98.2 1.4 2.3e-28 98.2 1.4 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.4 NM_001256574.1_3 - 1.2e-18 66.5 3.2 7.7e-05 22.7 0.0 5.6 1 1 4 5 5 5 5 Kelch motif Kelch_2 PF07646.13 NM_001256574.1_3 - 4.6e-18 64.3 2.6 0.00063 19.5 0.0 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.4 NM_001256574.1_3 - 8.4e-16 57.5 0.2 1.8e-06 27.7 0.0 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.4 NM_001256574.1_3 - 7.9e-14 51.4 3.2 0.00022 21.3 0.0 6.0 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_001256574.1_3 - 1.4e-11 43.9 5.0 2.2e-06 27.3 0.0 4.9 4 0 0 4 4 4 2 Kelch motif DUF3342 PF11822.6 NM_001256574.1_3 - 0.0029 17.7 0.0 0.0074 16.3 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) PFU PF09070.9 NM_001256574.1_3 - 0.14 12.3 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) LIM PF00412.20 NM_001014434.1_1 - 7.2e-32 109.3 21.0 1.6e-16 60.1 3.6 2.3 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 NM_001014434.1_1 - 8e-19 67.1 3.4 1.5e-18 66.2 3.4 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_001014434.1_1 - 0.00031 20.4 4.6 0.0013 18.5 4.6 2.1 1 1 0 1 1 1 1 Homeobox KN domain Homez PF11569.6 NM_001014434.1_1 - 0.0091 15.3 0.1 0.031 13.6 0.0 1.9 2 0 0 2 2 2 1 Homeodomain leucine-zipper encoding, Homez Xlink PF00193.15 NM_006691.3_2 - 4.3e-19 68.6 0.0 8.4e-19 67.6 0.0 1.5 1 0 0 1 1 1 1 Extracellular link domain EMP24_GP25L PF01105.22 NM_181836.5_1 - 6.2e-49 166.3 0.3 8.5e-49 165.8 0.3 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TANGO2 PF05742.10 NM_001322149.1_1 - 1.2e-46 159.7 0.3 5.9e-37 128.0 0.0 2.8 2 1 1 3 3 3 2 Transport and Golgi organisation 2 DUF758 PF05527.9 NM_001286817.1_2 - 6.8e-78 260.7 9.2 8.5e-78 260.4 9.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF758) COesterase PF00135.26 NM_001164238.1_1 - 3.1e-59 201.1 0.0 3.7e-59 200.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 NM_001164238.1_1 - 0.032 14.0 0.1 0.05 13.3 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Alba PF01918.19 NM_148178.2_3 - 3.5e-16 58.6 0.0 5.3e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Alba Sec7 PF01369.18 NM_001318024.1_3 - 3.9e-63 212.3 0.0 5.3e-63 211.9 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 NM_001318024.1_3 - 5.2e-26 91.1 0.1 8.7e-26 90.3 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_001318024.1_3 - 0.00026 21.3 0.1 0.00071 19.8 0.1 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain Syntaxin-6_N PF09177.9 NM_001318024.1_3 - 0.0072 16.7 0.7 3.7 8.0 0.0 2.3 2 0 0 2 2 2 2 Syntaxin 6, N-terminal PH_3 PF14593.4 NM_001318024.1_3 - 0.025 14.5 0.0 0.055 13.5 0.0 1.5 1 0 0 1 1 1 0 PH domain PH_6 PF15406.4 NM_001318024.1_3 - 0.16 12.2 0.1 6.2 7.0 0.1 2.3 1 1 1 2 2 2 0 Pleckstrin homology domain Ank_2 PF12796.5 NM_018708.2_2 - 1.2e-50 169.9 1.4 3.6e-17 62.6 0.0 5.4 3 2 1 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.28 NM_018708.2_2 - 1.2e-37 126.5 7.4 1e-05 25.6 0.0 8.9 8 0 0 8 8 8 8 Ankyrin repeat Ank_4 PF13637.4 NM_018708.2_2 - 1.2e-35 121.3 3.0 1.9e-08 34.6 0.1 7.5 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_018708.2_2 - 1.3e-35 117.2 3.3 0.00036 20.6 0.0 10.2 9 1 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.4 NM_018708.2_2 - 1.3e-34 117.6 14.9 2.1e-07 31.0 0.5 9.3 4 2 5 9 9 9 7 Ankyrin repeats (many copies) TPR_12 PF13424.4 NM_018708.2_2 - 8.3e-05 22.7 0.1 0.11 12.7 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_018708.2_2 - 0.0071 16.2 2.0 0.3 11.2 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.4 NM_018708.2_2 - 0.91 9.4 4.5 0.97 9.3 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat BRCT_2 PF16589.3 NM_001282548.1_2 - 8.4e-09 35.6 0.1 8e-06 26.1 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.24 NM_001282548.1_2 - 9.2e-08 32.3 0.0 0.0018 18.5 0.0 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-RING_6 PF14835.4 NM_001282548.1_2 - 0.028 14.1 0.1 0.073 12.8 0.1 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF3685 PF12452.6 NM_001167870.1_1 - 0.15 11.6 0.1 0.23 11.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) Med23 PF11573.6 NM_015979.3_2 - 0 2037.2 7.2 0 2037.0 7.2 1.0 1 0 0 1 1 1 1 Mediator complex subunit 23 SIM_C PF06621.10 NM_005069.4_3 - 7.8e-88 295.1 8.7 1e-87 294.7 8.7 1.2 1 0 0 1 1 1 1 Single-minded protein C-terminus PAS_3 PF08447.10 NM_005069.4_3 - 8.9e-23 80.3 1.1 1.3e-17 63.7 0.1 2.3 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 NM_005069.4_3 - 7.4e-19 67.8 0.5 4.3e-14 52.5 0.1 2.3 2 0 0 2 2 2 2 PAS domain PAS PF00989.23 NM_005069.4_3 - 1.5e-15 57.1 0.0 1.2e-11 44.5 0.0 2.3 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 NM_005069.4_3 - 0.00025 20.8 0.6 0.00051 19.8 0.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 NM_005069.4_3 - 0.0011 19.1 0.0 0.11 12.6 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.8 NM_005069.4_3 - 0.085 13.0 0.0 0.31 11.2 0.0 1.9 2 0 0 2 2 2 0 PAS fold ATF7IP_BD PF16788.3 NM_001286514.1_3 - 2.2e-63 214.3 8.7 2.2e-63 214.3 8.7 2.4 2 0 0 2 2 2 1 ATF-interacting protein binding domain fn3_4 PF16794.3 NM_001286514.1_3 - 2e-39 133.5 0.0 3.6e-39 132.7 0.0 1.4 1 0 0 1 1 1 1 Fibronectin-III type domain IRK PF01007.18 NM_001172417.1_1 - 1.6e-68 230.9 0.0 2.5e-68 230.3 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_001172417.1_1 - 0.0012 18.6 1.7 0.0012 18.6 1.7 1.7 2 0 0 2 2 2 1 Ion channel Cadherin PF00028.15 NM_004948.3_2 - 2.6e-85 280.9 2.5 1.7e-21 76.4 0.0 5.7 6 0 0 6 6 6 5 Cadherin domain Cadherin_pro PF08758.9 NM_004948.3_2 - 1.2e-21 76.5 0.0 2.8e-19 68.9 0.0 2.7 2 0 0 2 2 2 2 Cadherin prodomain like Cadherin_2 PF08266.10 NM_004948.3_2 - 4.1e-06 26.4 0.0 0.33 10.7 0.0 3.4 3 0 0 3 3 3 3 Cadherin-like Cadherin_3 PF16184.3 NM_004948.3_2 - 0.05 13.5 5.0 0.58 10.1 0.6 3.2 4 0 0 4 4 4 0 Cadherin-like Cadherin_C PF01049.15 NM_004948.3_3 - 0.00048 20.3 0.0 0.00075 19.7 0.0 1.2 1 0 0 1 1 1 1 Cadherin cytoplasmic region pKID PF02173.15 NM_001177969.1_2 - 0.15 11.5 0.6 0.28 10.6 0.6 1.4 1 0 0 1 1 1 0 pKID domain VWA PF00092.26 NM_001177969.1_3 - 1.2e-77 260.0 0.1 7.8e-41 140.1 0.0 2.7 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_2 PF13519.4 NM_001177969.1_3 - 2e-31 108.7 0.0 2.2e-14 53.9 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.17 NM_001177969.1_3 - 2.7e-26 91.4 0.1 6.6e-26 90.1 0.1 1.6 1 0 0 1 1 1 1 LCCL domain VWA_CoxE PF05762.12 NM_001177969.1_3 - 0.00021 20.6 0.0 0.065 12.5 0.0 2.4 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein DUF1194 PF06707.9 NM_001177969.1_3 - 0.00037 19.6 0.1 0.51 9.4 0.1 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF1194) Rxt3 PF08642.8 NM_001177969.1_3 - 0.034 14.8 0.0 0.18 12.5 0.0 2.1 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DENN PF02141.19 NM_017925.6_3 - 7.8e-63 211.7 5.3 1.5e-62 210.7 5.3 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 NM_017925.6_3 - 1.4e-14 54.5 1.5 2.5e-14 53.7 0.1 2.3 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.17 NM_017925.6_3 - 4.4e-12 45.7 1.9 4.4e-12 45.7 1.9 2.0 2 0 0 2 2 2 1 dDENN domain PPR_2 PF13041.4 NM_017925.6_3 - 0.00068 19.7 0.0 0.0097 16.0 0.0 2.3 1 1 1 2 2 2 1 PPR repeat family PPR_3 PF13812.4 NM_017925.6_3 - 0.0072 16.3 0.1 0.041 13.8 0.1 2.3 1 1 1 2 2 2 1 Pentatricopeptide repeat domain DUF2464 PF10240.7 NM_017925.6_3 - 0.0076 15.7 1.3 0.013 14.9 0.0 2.0 2 0 0 2 2 2 1 Multivesicular body subunit 12 PPR_long PF17177.2 NM_017925.6_3 - 0.1 11.8 0.0 0.32 10.2 0.0 1.7 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PROPR Homeobox PF00046.27 NM_003030.4_2 - 3.4e-24 84.3 2.7 7.6e-24 83.2 2.7 1.6 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 NM_003030.4_2 - 5.1e-07 29.2 2.9 1e-06 28.2 2.9 1.5 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 NM_003030.4_2 - 0.0022 17.7 0.2 0.0057 16.4 0.0 1.8 2 0 0 2 2 2 1 Homeobox KN domain DUF1899 PF08953.9 NM_001105237.2_2 - 1.5e-31 108.0 0.0 3.1e-31 106.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 NM_001105237.2_2 - 1.7e-21 75.7 0.1 3e-21 74.9 0.1 1.4 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 NM_001105237.2_2 - 7.8e-13 48.6 8.8 0.00011 22.8 0.6 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001105237.2_2 - 1.2e-05 25.4 0.4 0.039 14.1 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_001105237.2_2 - 0.024 14.4 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A RUN PF02759.17 NM_014328.4_3 - 3e-20 72.4 0.1 4.4e-20 71.9 0.1 1.2 1 0 0 1 1 1 1 RUN domain SH3_9 PF14604.4 NM_014328.4_3 - 1.4e-10 40.7 0.0 2.6e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_014328.4_3 - 1e-09 37.7 0.0 1.7e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_014328.4_3 - 1.3e-07 31.0 0.0 3.1e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PDGF PF00341.15 NM_002608.3_1 - 4.3e-23 81.3 9.6 9.8e-23 80.1 9.6 1.7 1 0 0 1 1 1 1 PDGF/VEGF domain PDGF_N PF04692.11 NM_002608.3_1 - 9.2e-12 45.5 0.0 2.3e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Platelet-derived growth factor, N terminal region KAR9 PF08580.8 NM_002608.3_1 - 7 4.9 8.9 12 4.2 8.9 1.2 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Mito_carr PF00153.25 NM_001164796.1_2 - 4.4e-36 122.6 0.9 4e-19 68.2 0.2 3.1 3 0 0 3 3 3 2 Mitochondrial carrier protein Ets PF00178.20 NM_001312656.1_1 - 5.9e-32 109.9 1.1 8.6e-32 109.3 1.1 1.2 1 0 0 1 1 1 1 Ets-domain HSF_DNA-bind PF00447.15 NM_001312656.1_1 - 0.12 12.9 0.2 0.19 12.2 0.2 1.2 1 0 0 1 1 1 0 HSF-type DNA-binding EF-hand_1 PF00036.30 NM_001199672.1_2 - 1.9e-14 51.9 22.9 0.0079 15.5 0.4 7.0 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.4 NM_001199672.1_2 - 2.7e-13 50.0 23.6 6.7e-06 26.3 0.6 4.3 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.4 NM_001199672.1_2 - 7.9e-11 40.8 26.5 0.0084 15.5 0.0 6.6 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.4 NM_001199672.1_2 - 5e-10 38.4 16.7 0.045 13.6 0.0 6.9 7 0 0 7 7 7 4 EF-hand domain EF-hand_8 PF13833.4 NM_001199672.1_2 - 5.6e-06 25.9 12.6 0.0068 16.0 0.0 4.5 5 0 0 5 5 5 2 EF-hand domain pair DUF4577 PF15145.4 NM_001134468.1_1 - 5.7e-70 233.1 0.9 8.2e-70 232.6 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) DUF948 PF06103.9 NM_001134468.1_1 - 0.029 14.5 0.3 0.045 13.9 0.3 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) CCDC85 PF10226.7 NM_001134468.1_1 - 0.097 12.2 0.5 0.14 11.7 0.5 1.2 1 0 0 1 1 1 0 CCDC85 family Ribosomal_L34e PF01199.16 NM_033625.3_1 - 7.5e-42 141.4 7.7 1.1e-41 140.9 7.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L34e Ank_4 PF13637.4 NM_198401.3_3 - 1.3e-19 70.2 0.6 7.7e-10 39.0 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_198401.3_3 - 4.8e-14 52.6 0.1 4e-12 46.4 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_198401.3_3 - 1.7e-12 47.2 0.3 7.8e-11 41.9 0.2 2.7 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 NM_198401.3_3 - 6.4e-09 35.7 4.2 0.00076 19.7 0.2 4.1 3 1 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 NM_198401.3_3 - 2.6e-08 33.4 0.3 0.0025 18.0 0.1 4.4 4 0 0 4 4 4 1 Ankyrin repeat PNMA PF14893.4 NM_173798.3_3 - 3.7e-42 144.8 0.0 5e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 PNMA zf-C2H2_10 PF16588.3 NM_173798.3_3 - 0.01 15.4 3.9 0.02 14.4 3.9 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger zf-CCHC PF00098.21 NM_173798.3_3 - 0.12 12.4 2.8 0.31 11.1 2.8 1.8 1 0 0 1 1 1 0 Zinc knuckle RSRP PF17069.3 NM_032195.2_2 - 7.9e-10 38.7 64.6 7.9e-10 38.7 64.6 4.9 3 2 2 5 5 5 2 Arginine/Serine-Rich protein 1 EF-hand_1 PF00036.30 NM_006097.4_3 - 7.3e-15 53.2 7.1 3.8e-07 29.0 1.6 4.0 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 NM_006097.4_3 - 8.8e-13 48.4 5.0 1.3e-06 28.6 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_006097.4_3 - 2.1e-11 42.7 7.5 2.4e-07 30.0 0.9 3.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 NM_006097.4_3 - 2.8e-06 26.8 6.5 0.0087 15.7 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_006097.4_3 - 2.6e-05 23.4 3.1 5e-05 22.5 1.5 2.2 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.9 NM_006097.4_3 - 0.0012 19.6 0.1 0.0035 18.1 0.1 1.7 1 1 1 2 2 2 1 EF-hand domain GPHH PF16905.3 NM_006097.4_3 - 0.0017 18.0 0.0 2.3 8.0 0.0 2.3 2 0 0 2 2 2 2 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_9 PF14658.4 NM_006097.4_3 - 0.024 14.8 0.0 7.8 6.8 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain UPF0154 PF03672.11 NM_006097.4_3 - 0.03 14.2 0.0 10 6.1 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) SPARC_Ca_bdg PF10591.7 NM_006097.4_3 - 0.12 12.5 0.3 0.26 11.5 0.3 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region 7tm_4 PF13853.4 NM_001005192.2_1 - 2.3e-50 171.8 24.3 2.9e-50 171.5 24.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005192.2_1 - 2.5e-23 82.5 28.7 4.3e-23 81.8 28.7 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001005192.2_1 - 0.00021 20.7 28.5 0.00099 18.4 28.5 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DPM3 PF08285.9 NM_018973.3_3 - 3.9e-30 103.7 0.0 6.3e-30 103.1 0.0 1.3 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) IRK PF01007.18 NM_002239.3_1 - 1.1e-138 461.6 0.2 1.5e-138 461.1 0.2 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_002239.3_1 - 1.4 8.8 7.8 4.1 7.3 7.8 1.9 1 1 0 1 1 1 0 Ion channel MRP-S22 PF10245.7 NM_020191.2_3 - 6.2e-106 353.4 2.6 6.2e-106 353.4 2.6 1.3 2 0 0 2 2 2 1 Mitochondrial 28S ribosomal protein S22 NDUF_B6 PF09782.7 NM_001199987.1_2 - 6.1e-30 104.3 6.6 2.4e-19 69.9 3.8 2.3 1 1 1 2 2 2 2 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Arf PF00025.19 NM_001134758.3_2 - 6.5e-39 133.0 0.0 9.3e-39 132.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 NM_001134758.3_2 - 9.2e-13 48.3 0.1 1.3e-12 47.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_001134758.3_2 - 9.7e-11 41.4 0.1 1.3e-10 40.9 0.1 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 NM_001134758.3_2 - 4.8e-08 32.4 0.1 0.00014 21.1 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.8 NM_001134758.3_2 - 3.3e-07 29.8 0.0 4.6e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.10 NM_001134758.3_2 - 4.6e-07 29.3 0.0 6.4e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 NM_001134758.3_2 - 2.9e-06 27.2 0.0 4.1e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 7tm_1 PF00001.19 NM_004101.3_1 - 2.8e-34 118.5 44.9 2.6e-33 115.3 19.1 3.1 3 0 0 3 3 3 2 7 transmembrane receptor (rhodopsin family) zf-H2C2_2 PF13465.4 NM_017652.3_3 - 1.5e-76 249.5 78.8 1.4e-08 34.7 0.5 14.1 13 1 0 13 13 13 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_017652.3_3 - 1.2e-46 154.5 87.8 2.3e-06 27.6 0.7 12.8 14 0 0 14 14 12 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_017652.3_3 - 7.7e-28 94.6 81.9 0.0017 18.9 0.3 12.5 13 0 0 13 13 12 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_017652.3_3 - 3.1e-23 81.1 64.9 5.6e-05 22.9 0.5 11.7 11 0 0 11 11 10 9 C2H2-type zinc finger KRAB PF01352.25 NM_017652.3_3 - 5.5e-21 73.8 0.3 9.6e-21 73.1 0.3 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_017652.3_3 - 4.5e-14 52.2 39.8 0.022 15.0 0.0 12.0 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_017652.3_3 - 7.8e-09 35.4 48.8 0.036 14.1 2.1 8.5 5 3 3 8 8 8 5 Zinc ribbon domain zf-LYAR PF08790.9 NM_017652.3_3 - 6.6e-07 29.0 35.6 0.023 14.4 0.7 10.2 11 0 0 11 11 11 4 LYAR-type C2HC zinc finger DZR PF12773.5 NM_017652.3_3 - 2.7e-06 27.2 32.4 0.16 11.9 0.8 6.4 3 1 1 4 4 4 2 Double zinc ribbon zf-C2H2_11 PF16622.3 NM_017652.3_3 - 6.4e-05 22.5 62.3 0.035 13.7 0.1 10.2 11 0 0 11 11 10 4 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_017652.3_3 - 0.0001 22.8 32.9 0.19 12.4 0.3 5.8 2 1 6 8 8 7 6 zinc-ribbon family XPA_N PF01286.16 NM_017652.3_3 - 0.00011 22.0 50.5 2.5 8.1 0.8 11.1 11 0 0 11 11 11 3 XPA protein N-terminal HypA PF01155.17 NM_017652.3_3 - 0.032 14.1 32.1 2.5 8.0 0.7 6.4 2 1 4 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HC_2 PF13913.4 NM_017652.3_3 - 0.11 12.2 40.7 1 9.2 0.1 9.3 9 0 0 9 9 9 0 zinc-finger of a C2HC-type YhfH PF14149.4 NM_017652.3_3 - 0.12 12.2 37.8 14 5.7 0.2 9.8 10 0 0 10 10 9 0 YhfH-like protein zf-AN1 PF01428.14 NM_017652.3_3 - 0.17 12.0 36.8 25 5.0 0.1 10.4 10 0 0 10 10 10 0 AN1-like Zinc finger C1_1 PF00130.20 NM_017652.3_3 - 0.23 11.2 41.5 3.3 7.5 2.2 8.3 3 2 5 8 8 8 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CpXC PF14353.4 NM_017652.3_3 - 0.52 10.2 26.9 10 6.0 0.1 8.6 2 1 7 9 9 9 0 CpXC protein ADK_lid PF05191.12 NM_017652.3_3 - 0.58 10.1 20.0 28 4.7 0.3 7.2 4 3 3 7 7 7 0 Adenylate kinase, active site lid TFIIS_C PF01096.16 NM_017652.3_3 - 3.3 7.5 42.8 11 5.9 0.1 10.2 11 0 0 11 11 11 0 Transcription factor S-II (TFIIS) KCNQ_channel PF03520.12 NM_172107.3_2 - 3.4e-90 300.9 0.0 4.6e-90 300.4 0.0 1.2 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel KCNQC3-Ank-G_bd PF11956.6 NM_172107.3_2 - 8.7e-46 154.3 0.4 1.7e-45 153.4 0.4 1.5 1 0 0 1 1 1 1 Ankyrin-G binding motif of KCNQ2-3 KCNQ2_u3 PF16642.3 NM_172107.3_2 - 8.1e-36 122.8 13.0 8.1e-36 122.8 13.0 3.0 3 0 0 3 3 3 1 Unstructured region on Potassium channel subunit alpha KvLQT2 Ion_trans PF00520.29 NM_172107.3_2 - 6.9e-29 100.6 7.2 1.1e-28 100.0 7.2 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 NM_172107.3_2 - 2.8e-12 46.3 3.3 6.2e-12 45.2 3.3 1.6 1 0 0 1 1 1 1 Ion channel LRR_8 PF13855.4 NM_006670.4_1 - 1e-33 114.8 26.5 4.2e-12 45.5 0.1 3.9 3 2 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.5 NM_006670.4_1 - 7.6e-10 38.7 18.7 1.6e-05 25.0 4.5 4.7 3 2 3 6 6 6 4 Leucine Rich repeats (2 copies) LRRNT PF01462.16 NM_006670.4_1 - 1.1e-07 31.2 2.8 4.1e-07 29.4 2.8 2.1 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRRCT PF01463.22 NM_006670.4_1 - 0.00069 19.8 0.0 0.0026 18.0 0.0 2.1 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.31 NM_006670.4_1 - 0.00086 19.3 14.0 1.6 9.4 0.1 6.2 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.4 NM_006670.4_1 - 0.0032 16.8 0.1 0.36 10.2 0.3 2.2 2 0 0 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.4 NM_006670.4_1 - 0.029 14.3 17.1 1.9 8.6 0.1 5.8 5 0 0 5 5 5 0 Leucine Rich repeat Lectin_C PF00059.19 NM_005411.4_1 - 1e-22 80.8 0.0 1.5e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 NM_005411.4_1 - 8e-10 38.2 33.0 1.5e-05 24.5 14.3 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) 7tm_4 PF13853.4 NM_006637.1_1 - 6.2e-50 170.3 19.3 7.3e-50 170.1 19.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_006637.1_1 - 4.9e-20 71.8 18.4 8.7e-20 70.9 18.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ECSCR PF15820.3 NM_006637.1_1 - 0.15 11.8 1.9 0.3 10.8 0.3 2.1 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Hist_deacetyl PF00850.17 NM_006044.3_2 - 1.6e-172 572.9 0.0 7.9e-87 291.4 0.0 2.1 2 0 0 2 2 2 2 Histone deacetylase domain zf-UBP PF02148.17 NM_006044.3_2 - 1.3e-16 60.5 12.8 1.3e-16 60.5 12.8 2.2 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein Lactamase_B_6 PF16661.3 NM_001145159.2_3 - 2.2e-16 59.7 0.2 9.9e-15 54.3 0.1 2.8 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.6 NM_001145159.2_3 - 4.7e-07 29.9 0.0 9.1e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain Beta_lactamase3 PF17030.3 NM_001145159.2_3 - 0.011 14.8 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 Putative beta-lactamase-like family DZF PF07528.12 NM_017620.2_3 - 3.1e-108 361.0 0.0 4.2e-108 360.5 0.0 1.2 1 0 0 1 1 1 1 DZF domain dsrm PF00035.24 NM_017620.2_3 - 2.6e-24 85.6 0.1 2.2e-12 47.4 0.1 2.7 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.5 NM_017620.2_3 - 0.049 13.8 3.8 3.4 7.8 0.0 3.6 3 0 0 3 3 3 0 double strand RNA binding domain from DEAD END PROTEIN 1 PRY PF13765.4 NM_173553.2_1 - 3.8e-16 58.3 0.0 9.4e-16 57.0 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 NM_173553.2_1 - 3.9e-12 46.2 0.0 7.3e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 NM_173553.2_1 - 5.3e-06 26.4 7.8 1.1e-05 25.3 7.8 1.6 1 0 0 1 1 1 1 B-box zinc finger zf-UBR PF02207.18 NM_173553.2_1 - 0.034 14.2 4.0 0.097 12.7 4.0 1.8 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Sigma54_CBD PF04963.11 NM_173553.2_1 - 0.16 11.6 5.7 0.11 12.2 1.7 2.3 1 1 0 2 2 2 0 Sigma-54 factor, core binding domain Exonuc_VII_L PF02601.13 NM_173553.2_1 - 1.3 8.4 13.5 2.7 7.4 13.5 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit CENP-K PF11802.6 NM_173553.2_1 - 1.4 8.3 19.4 2 7.8 19.4 1.2 1 0 0 1 1 1 0 Centromere-associated protein K ZYG-11_interact PF05884.10 NM_173553.2_1 - 4.8 6.4 7.2 30 3.8 4.6 2.6 2 1 0 2 2 2 0 Interactor of ZYG-11 BMFP PF04380.11 NM_173553.2_1 - 5.8 7.3 15.7 0.22 11.9 5.5 2.8 1 1 1 3 3 3 0 Membrane fusogenic activity zf-A20 PF01754.14 NM_001278243.1_2 - 7.7e-12 44.8 8.8 3.2e-11 42.8 8.8 2.2 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.14 NM_001278243.1_2 - 1.7e-08 34.3 8.2 1.7e-08 34.3 8.2 2.7 2 0 0 2 2 2 1 AN1-like Zinc finger zf-H2C2_2 PF13465.4 NM_198893.2_1 - 3.3e-146 469.7 147.8 4.3e-08 33.1 1.0 21.9 21 0 0 21 21 21 21 Zinc-finger double domain zf-C2H2 PF00096.24 NM_198893.2_1 - 1.1e-115 372.0 157.2 8.1e-07 29.0 1.0 20.7 20 0 0 20 20 20 20 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_198893.2_1 - 7.9e-54 175.5 145.7 0.0028 18.2 0.4 20.9 20 0 0 20 20 20 20 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_198893.2_1 - 9.1e-32 108.3 136.1 0.0098 15.7 0.7 22.2 20 3 0 20 20 20 17 C2H2-type zinc finger KRAB PF01352.25 NM_198893.2_1 - 1.5e-25 88.4 0.1 2.7e-25 87.6 0.1 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_198893.2_1 - 1.2e-24 86.0 101.9 0.03 14.3 2.8 16.7 4 3 16 20 20 20 18 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_198893.2_1 - 6.1e-21 73.7 84.1 0.44 10.2 0.1 20.1 20 0 0 20 20 20 10 zinc-finger C2H2-type XPA_N PF01286.16 NM_198893.2_1 - 8.8e-17 60.7 61.2 9.6 6.2 0.0 20.0 20 0 0 20 20 20 0 XPA protein N-terminal C1_1 PF00130.20 NM_198893.2_1 - 2.4e-13 49.6 69.8 0.16 11.7 0.7 14.1 1 1 17 18 18 18 15 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.3 NM_198893.2_1 - 6e-09 36.4 83.0 0.39 11.4 0.6 10.8 1 1 11 14 14 14 13 zinc-ribbon family C1_4 PF07975.10 NM_198893.2_1 - 6.7e-06 26.2 84.2 0.038 14.1 0.9 12.8 3 2 8 14 14 14 5 TFIIH C1-like domain HypA PF01155.17 NM_198893.2_1 - 2.7e-05 24.0 71.3 2.1 8.3 1.0 10.9 1 1 11 12 12 12 5 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_jaz PF12171.6 NM_198893.2_1 - 0.022 14.9 86.5 4.4 7.6 0.4 19.3 20 0 0 20 20 20 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_198893.2_1 - 0.026 14.7 71.4 0.37 11.0 1.5 10.1 3 2 5 12 12 12 0 zinc-finger-containing domain tRNA-synt_2d PF01409.18 NM_198893.2_1 - 0.78 9.0 10.1 10 5.4 0.0 5.2 5 2 2 7 7 7 0 tRNA synthetases class II core domain (F) FYDLN_acid PF09538.8 NM_198893.2_1 - 5.6 7.6 44.4 32 5.1 0.2 13.9 1 1 14 15 15 15 0 Protein of unknown function (FYDLN_acid) ZZ PF00569.15 NM_198893.2_1 - 9.3 6.0 93.8 12 5.6 0.3 19.3 20 0 0 20 20 20 0 Zinc finger, ZZ type Corona_7 PF02398.14 NM_198893.2_2 - 2.8 8.4 12.0 63 4.1 0.0 6.0 7 1 0 7 7 7 0 Coronavirus protein 7 Lectin_C PF00059.19 NM_194450.2_2 - 6.1e-21 75.1 1.7 6.1e-21 75.1 1.7 1.5 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 NM_194450.2_2 - 0.0023 17.5 0.3 0.0035 16.9 0.3 1.2 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like ELF PF03317.11 NM_194450.2_2 - 0.017 14.5 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 ELF protein Dysbindin PF04440.14 NM_001042610.2_2 - 2.6e-40 137.8 0.0 4.2e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) PDEase_I PF00233.17 NM_001243121.1_1 - 8e-94 313.7 2.9 1.5e-93 312.8 2.9 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase NadA PF02445.14 NM_001243121.1_1 - 0.12 11.3 0.1 0.22 10.5 0.1 1.4 1 0 0 1 1 1 0 Quinolinate synthetase A protein ATP-synt_E PF05680.10 NM_007100.3_2 - 2.2e-17 63.0 0.1 3.2e-17 62.5 0.1 1.2 1 0 0 1 1 1 1 ATP synthase E chain DUF1043 PF06295.10 NM_007100.3_2 - 0.068 13.0 0.0 0.087 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) I-set PF07679.14 NM_001291815.1_1 - 0 2121.8 0.0 3.6e-20 71.7 0.0 43.5 43 0 0 43 43 43 43 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001291815.1_1 - 0 1948.6 18.1 1.9e-15 57.1 0.3 43.4 43 0 0 43 43 43 43 Immunoglobulin domain Ig_2 PF13895.4 NM_001291815.1_1 - 0 1445.3 0.0 3.9e-12 46.2 0.3 43.3 41 2 2 43 43 43 43 Immunoglobulin domain ig PF00047.23 NM_001291815.1_1 - 0 1139.3 0.0 9.7e-09 35.1 0.0 44.5 43 2 0 43 43 43 43 Immunoglobulin domain V-set PF07686.15 NM_001291815.1_1 - 2.8e-149 487.5 61.0 0.007 16.4 0.0 71.3 46 34 13 59 59 58 32 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001291815.1_1 - 3.8e-112 366.5 67.1 0.016 15.1 0.1 42.2 42 0 0 42 42 42 30 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 NM_001291815.1_1 - 3e-69 229.3 0.0 0.95 9.8 0.0 36.9 40 0 0 40 40 38 11 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain G2F PF07474.10 NM_001291815.1_1 - 8.5e-55 185.2 0.0 2.5e-54 183.7 0.0 1.8 2 0 0 2 2 2 1 G2F domain EGF_CA PF07645.13 NM_001291815.1_1 - 1.2e-47 159.7 69.1 1.4e-09 37.8 4.3 9.1 8 0 0 8 8 7 6 Calcium-binding EGF domain Izumo-Ig PF16706.3 NM_001291815.1_1 - 7.9e-39 131.5 0.1 4 7.4 0.0 31.9 37 0 0 37 37 34 2 Izumo-like Immunoglobulin domain C1-set PF07654.13 NM_001291815.1_1 - 6.4e-33 112.9 13.1 1.3 9.4 0.1 31.2 38 0 0 38 38 37 1 Immunoglobulin C1-set domain cEGF PF12662.5 NM_001291815.1_1 - 2.6e-30 103.8 44.7 1.9e-09 37.2 0.2 8.7 8 0 0 8 8 8 7 Complement Clr-like EGF-like V-set_CD47 PF08204.9 NM_001291815.1_1 - 7.3e-17 61.4 0.0 29 4.5 0.0 17.1 20 0 0 20 20 18 0 CD47 immunoglobulin-like domain BiPBP_C PF06832.10 NM_001291815.1_1 - 7.3e-16 57.9 16.5 16 5.5 0.0 21.9 24 1 1 25 25 24 0 Penicillin-Binding Protein C-terminus Family C2-set PF05790.13 NM_001291815.1_1 - 8.8e-14 51.3 0.9 6.3 6.9 0.0 17.9 24 0 0 24 24 21 1 Immunoglobulin C2-set domain FXa_inhibition PF14670.4 NM_001291815.1_1 - 2e-12 47.0 91.0 1.3e-06 28.4 6.1 8.4 8 0 0 8 8 8 4 Coagulation Factor Xa inhibitory site Receptor_2B4 PF11465.6 NM_001291815.1_1 - 2.1e-12 47.1 0.0 28 4.8 0.0 15.5 21 0 0 21 21 17 0 Natural killer cell receptor 2B4 Herpes_gE PF02480.14 NM_001291815.1_1 - 2.7e-12 46.1 2.0 2.5 6.6 0.0 13.7 16 3 0 18 18 18 2 Alphaherpesvirus glycoprotein E Sp38 PF07354.10 NM_001291815.1_1 - 6.3e-09 35.0 0.0 1.4 7.6 0.0 8.9 10 0 0 10 10 10 1 Zona-pellucida-binding protein (Sp38) EGF PF00008.25 NM_001291815.1_1 - 9.3e-07 28.9 75.1 0.0022 18.2 5.4 8.8 7 0 0 7 7 7 4 EGF-like domain EGF_3 PF12947.5 NM_001291815.1_1 - 0.00031 20.7 3.5 0.00031 20.7 3.5 7.5 7 0 0 7 7 7 2 EGF domain VWA_2 PF13519.4 NM_001291815.1_1 - 0.013 16.0 0.0 0.03 14.8 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain SET PF00856.26 NM_001080517.2_2 - 2.1e-05 24.9 2.6 3.6e-05 24.1 0.1 2.6 2 1 0 2 2 2 1 SET domain NB-ARC PF00931.20 NM_181868.1_2 - 3.8e-81 272.1 1.1 5.8e-81 271.5 1.1 1.3 1 0 0 1 1 1 1 NB-ARC domain WD40 PF00400.30 NM_181868.1_2 - 1.2e-58 193.6 40.5 2.1e-08 34.6 0.2 12.5 12 0 0 12 12 12 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_181868.1_2 - 4.4e-25 87.7 11.1 0.00077 19.6 0.1 8.6 5 4 3 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain CARD PF00619.19 NM_181868.1_2 - 8.8e-19 67.2 0.2 2e-18 66.0 0.2 1.7 1 0 0 1 1 1 1 Caspase recruitment domain Ge1_WD40 PF16529.3 NM_181868.1_2 - 3e-10 39.4 5.4 0.36 9.6 0.1 7.2 5 2 1 8 8 8 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.3 NM_181868.1_2 - 3.5e-09 36.3 0.5 0.0065 15.7 0.1 3.6 2 1 1 3 3 3 3 WD40-like domain CARD_2 PF16739.3 NM_181868.1_2 - 1.8e-08 34.1 0.1 4.3e-08 32.9 0.1 1.7 1 0 0 1 1 1 1 Caspase recruitment domain AAA_16 PF13191.4 NM_181868.1_2 - 3.1e-05 24.3 0.0 5.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Nbas_N PF15492.4 NM_181868.1_2 - 0.03 13.5 0.0 5.5 6.1 0.0 2.9 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal NACHT PF05729.10 NM_181868.1_2 - 0.094 12.5 0.1 0.25 11.1 0.1 1.7 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.4 NM_181868.1_2 - 0.1 12.8 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Cactin_mid PF10312.7 NM_181868.1_2 - 0.12 11.9 0.4 0.35 10.4 0.4 1.7 1 1 0 1 1 1 0 Conserved mid region of cactin Mito_carr PF00153.25 NM_001271641.1_1 - 1.8e-14 53.3 0.2 1.6e-07 31.0 0.0 2.9 3 0 0 3 3 3 2 Mitochondrial carrier protein ABC_membrane PF00664.21 NM_001301829.1_1 - 6.4e-76 255.5 33.6 1.9e-45 155.5 6.4 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 NM_001301829.1_1 - 1.7e-55 187.2 0.2 4.1e-30 104.9 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 NM_001301829.1_1 - 6.5e-12 45.2 1.8 0.011 15.0 0.1 4.3 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.21 NM_001301829.1_1 - 2.9e-07 30.4 0.4 0.0028 17.6 0.2 2.8 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.4 NM_001301829.1_1 - 3.6e-07 30.1 1.2 0.48 10.1 0.1 4.5 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 NM_001301829.1_1 - 7.5e-07 28.7 0.4 0.036 13.6 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.4 NM_001301829.1_1 - 1.4e-06 28.7 0.2 0.0083 16.4 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.14 NM_001301829.1_1 - 2.9e-06 27.1 0.1 0.065 13.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Dynamin_N PF00350.21 NM_001301829.1_1 - 0.00084 19.3 3.0 0.13 12.2 0.1 2.7 2 1 0 2 2 2 2 Dynamin family AAA_22 PF13401.4 NM_001301829.1_1 - 0.0014 18.8 1.3 1.9 8.6 0.0 3.4 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.4 NM_001301829.1_1 - 0.0024 17.5 0.3 1.2 8.7 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.4 NM_001301829.1_1 - 0.004 17.6 0.1 0.9 9.9 0.1 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.15 NM_001301829.1_1 - 0.0047 16.6 1.7 1.3 8.6 0.0 3.3 4 0 0 4 4 4 1 IstB-like ATP binding protein T2SSE PF00437.18 NM_001301829.1_1 - 0.019 13.9 0.0 0.98 8.3 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.17 NM_001301829.1_1 - 0.042 13.3 0.7 2.8 7.4 0.1 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF815 PF05673.11 NM_001301829.1_1 - 0.099 11.7 0.3 5 6.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA PF00004.27 NM_001301829.1_1 - 0.12 12.6 1.0 13 6.1 0.0 3.5 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.10 NM_001301829.1_1 - 0.12 11.5 0.3 8.7 5.4 0.1 2.6 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.15 NM_001301829.1_1 - 0.16 11.9 1.2 0.62 9.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF87 Neurexophilin PF06312.10 NM_145037.2_2 - 1.5e-63 213.9 0.0 2.2e-63 213.4 0.0 1.2 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.17 NM_145037.2_2 - 0.007 17.0 0.0 0.012 16.3 0.0 1.3 1 0 0 1 1 1 1 Filamin/ABP280 repeat PIG-P PF08510.10 NM_016430.3_3 - 1.4e-32 112.0 3.8 2e-32 111.5 3.8 1.2 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.10 NM_016430.3_3 - 0.044 14.0 2.3 0.085 13.0 2.3 1.4 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PI3K_1B_p101 PF10486.7 NM_001172085.1_1 - 1.7 6.2 8.7 2.2 5.8 8.7 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Secretin_N_2 PF07655.11 NM_001172085.1_1 - 2.7 8.5 23.1 4.7 7.7 23.1 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain TBP PF00352.19 NM_001172085.1_3 - 2.2e-65 216.5 0.3 9.8e-32 108.6 0.1 2.4 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 PF10513.7 NM_001172085.1_3 - 8.7e-05 22.8 8.1 0.00012 22.4 8.1 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like Presenilin PF01080.15 NM_001172085.1_3 - 0.00078 18.2 11.4 0.0017 17.1 11.4 1.6 1 0 0 1 1 1 1 Presenilin DDHD PF02862.15 NM_001172085.1_3 - 0.0014 18.6 6.2 0.002 18.2 6.2 1.2 1 0 0 1 1 1 1 DDHD domain Peptidase_S64 PF08192.9 NM_001172085.1_3 - 0.0047 15.4 4.9 0.0061 15.0 4.9 1.2 1 0 0 1 1 1 1 Peptidase family S64 TMEM51 PF15345.4 NM_001172085.1_3 - 0.014 15.1 9.4 0.023 14.4 9.4 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 MMR1 PF08505.8 NM_001172085.1_3 - 0.022 15.0 12.8 0.03 14.5 12.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein ABC2_membrane_2 PF12679.5 NM_001172085.1_3 - 0.038 13.1 0.4 0.054 12.6 0.4 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein SpoIIP PF07454.9 NM_001172085.1_3 - 0.19 11.0 14.8 0.27 10.5 14.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4746 PF15928.3 NM_001172085.1_3 - 0.2 10.9 7.2 0.28 10.5 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PAT1 PF09770.7 NM_001172085.1_3 - 0.56 8.3 31.1 0.76 7.8 31.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3295 PF11702.6 NM_001172085.1_3 - 0.6 9.3 16.9 0.83 8.8 16.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) FemAB PF02388.14 NM_001172085.1_3 - 0.67 8.6 15.0 0.95 8.1 15.0 1.1 1 0 0 1 1 1 0 FemAB family BORG_CEP PF14957.4 NM_001172085.1_3 - 0.79 10.8 7.8 1.3 10.0 7.8 1.3 1 0 0 1 1 1 0 Cdc42 effector Tim54 PF11711.6 NM_001172085.1_3 - 1 7.9 15.6 1.6 7.3 15.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ndc1_Nup PF09531.8 NM_001172085.1_3 - 2.2 6.7 16.7 3 6.3 16.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1980 PF09323.8 NM_001172085.1_3 - 4.9 6.9 9.7 8.9 6.0 9.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) TFIIA PF03153.11 NM_001172085.1_3 - 6.6 6.5 48.9 9.5 6.0 48.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3408 PF11888.6 NM_001172085.1_3 - 6.8 6.7 16.2 13 5.8 16.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) GREB1 PF15782.3 NM_001172085.1_3 - 7 3.5 19.1 9.5 3.0 19.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PIH1 PF08190.10 NM_001172085.1_3 - 7.7 6.1 23.7 12 5.5 23.7 1.2 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 RNase_T PF00929.22 NM_001301701.1_1 - 4.7e-37 128.0 0.0 6e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 Exonuclease 7tm_4 PF13853.4 NM_001005471.1_1 - 6.2e-46 157.2 18.1 7.9e-46 156.9 18.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005471.1_1 - 9.2e-23 80.7 20.3 1.9e-22 79.6 20.3 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2768 PF10966.6 NM_001005471.1_1 - 0.55 10.6 10.1 0.98 9.8 3.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) Glypican PF01153.17 NM_001448.2_3 - 7.2e-233 774.3 4.4 9.3e-233 773.9 4.4 1.0 1 0 0 1 1 1 1 Glypican DUF1910 PF08928.8 NM_001448.2_3 - 0.1 12.5 0.9 0.56 10.1 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) Ribophorin_II PF05817.12 NM_001324302.1_3 - 1.7e-196 654.4 25.1 9.1e-167 556.2 13.7 2.0 1 1 1 2 2 2 2 Oligosaccharyltransferase subunit Ribophorin II CEP63 PF17045.3 NM_001042384.1_1 - 9.6e-105 350.2 57.6 9.6e-105 350.2 57.6 2.1 2 0 0 2 2 2 1 Centrosomal protein of 63 kDa Filament PF00038.19 NM_001042384.1_1 - 0.0025 17.3 49.8 0.0025 17.3 49.8 2.1 1 1 1 2 2 2 1 Intermediate filament protein Spc7 PF08317.9 NM_001042384.1_1 - 0.044 12.5 82.5 0.067 11.9 24.9 3.8 1 1 3 4 4 4 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 NM_001042384.1_1 - 5.7 6.1 20.6 1.8 7.8 2.9 3.6 1 1 1 3 3 3 0 Reovirus sigma C capsid protein GCR PF02155.13 NM_001204264.1_1 - 6.6e-186 617.6 9.5 8.2e-186 617.3 9.5 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 NM_001204264.1_1 - 9.2e-30 103.6 6.4 1e-29 103.5 4.7 1.8 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_001204264.1_1 - 1.9e-27 95.4 13.0 1.9e-27 95.4 13.0 2.1 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Ras PF00071.20 NM_001008749.2_1 - 7.1e-55 184.9 0.8 8.7e-55 184.6 0.8 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001008749.2_1 - 1.8e-34 118.4 0.4 2.6e-34 117.9 0.4 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001008749.2_1 - 1.3e-14 53.9 0.1 1.7e-14 53.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_001008749.2_1 - 0.00021 20.6 0.1 0.00031 20.0 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 NM_001008749.2_1 - 0.0011 18.5 0.4 0.0041 16.5 0.4 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 NM_001008749.2_1 - 0.0014 18.6 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.8 NM_001008749.2_1 - 0.0022 17.3 0.1 0.0041 16.4 0.0 1.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 NM_001008749.2_1 - 0.0059 15.7 0.1 3.4 6.6 0.1 2.6 1 1 1 2 2 2 2 G-protein alpha subunit PduV-EutP PF10662.7 NM_001008749.2_1 - 0.0064 16.1 0.5 0.033 13.8 0.5 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.16 NM_001008749.2_1 - 0.0097 15.3 0.2 0.68 9.3 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.14 NM_001008749.2_1 - 0.017 14.9 0.0 4.1 7.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 TniB PF05621.9 NM_001008749.2_1 - 0.033 13.2 0.0 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PPDFL PF15060.4 NM_001256596.1_1 - 1.4e-16 60.9 0.4 2.1e-16 60.3 0.4 1.2 1 0 0 1 1 1 1 Differentiation and proliferation regulator Guanylate_kin PF00625.19 NM_000858.5_1 - 8e-69 230.8 0.0 9.8e-69 230.5 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.4 NM_000858.5_1 - 3.3e-06 27.2 0.3 3.3e-05 23.9 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.4 NM_000858.5_1 - 8.6e-06 26.2 0.0 1.7e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 NM_000858.5_1 - 5.8e-05 23.4 1.9 0.00021 21.6 1.9 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 NM_000858.5_1 - 0.00077 19.3 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.25 NM_000858.5_1 - 0.00088 19.7 0.1 0.0012 19.2 0.1 1.4 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.4 NM_000858.5_1 - 0.0011 19.1 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.21 NM_000858.5_1 - 0.0012 18.8 0.0 0.0022 18.0 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.4 NM_000858.5_1 - 0.0068 16.0 0.1 0.012 15.1 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain cobW PF02492.17 NM_000858.5_1 - 0.0068 15.9 0.1 0.016 14.7 0.1 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.10 NM_000858.5_1 - 0.0075 16.1 0.1 0.023 14.5 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.4 NM_000858.5_1 - 0.016 15.3 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 NM_000858.5_1 - 0.025 14.2 0.2 0.16 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.4 NM_000858.5_1 - 0.028 14.0 0.0 0.67 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.4 NM_000858.5_1 - 0.044 13.7 0.0 0.075 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 NM_000858.5_1 - 0.045 14.0 0.0 0.072 13.4 0.0 1.3 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.13 NM_000858.5_1 - 0.049 13.4 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 NTPase Zeta_toxin PF06414.10 NM_000858.5_1 - 0.056 12.6 0.2 0.11 11.6 0.2 1.4 1 0 0 1 1 1 0 Zeta toxin dNK PF01712.17 NM_000858.5_1 - 0.062 13.0 0.1 1.1 8.9 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase DUF2075 PF09848.7 NM_000858.5_1 - 0.091 11.8 0.1 1.5 7.8 0.1 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.12 NM_000858.5_1 - 0.12 12.3 1.2 0.59 10.0 0.1 2.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.4 NM_000858.5_1 - 0.13 12.6 0.2 1 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA PF00004.27 NM_000858.5_1 - 0.14 12.4 0.0 0.34 11.2 0.0 1.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.16 NM_000858.5_1 - 0.19 11.5 0.0 0.31 10.8 0.0 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_23 PF13476.4 NM_000858.5_1 - 0.93 9.8 2.3 2.4 8.5 2.3 1.8 1 1 0 1 1 1 0 AAA domain Ribosomal_L22e PF01776.15 NM_000983.3_2 - 3.2e-52 175.4 1.0 5.1e-52 174.7 1.0 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family Glyco_transf_49 PF13896.4 NM_006876.2_2 - 2.1e-102 342.7 0.0 2.6e-102 342.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan ICAP-1_inte_bdg PF10480.7 NM_004763.4_2 - 3.8e-131 435.0 3.6 4.8e-131 434.7 3.6 1.1 1 0 0 1 1 1 1 Beta-1 integrin binding protein PID PF00640.21 NM_004763.4_2 - 0.0029 17.5 0.0 0.0054 16.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Spo7_2_N PF15407.4 NM_001193517.1_1 - 0.044 13.3 0.0 0.14 11.7 0.0 1.9 1 0 0 1 1 1 0 Sporulation protein family 7 Snf7 PF03357.19 NM_001193517.1_3 - 1.8e-18 66.6 30.3 1.1e-13 51.0 9.9 2.8 2 1 1 3 3 3 2 Snf7 PYC_OADA PF02436.16 NM_001193517.1_3 - 0.089 12.4 0.7 0.17 11.5 0.6 1.5 1 1 0 1 1 1 0 Conserved carboxylase domain P53 PF00870.16 NM_001126118.1_2 - 1.4e-114 380.4 1.2 2e-114 379.9 1.2 1.2 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 NM_001126118.1_2 - 7.1e-18 63.5 1.6 1.2e-17 62.8 1.6 1.4 1 0 0 1 1 1 1 P53 tetramerisation motif P53_TAD PF08563.9 NM_001126118.1_2 - 2.9e-09 36.0 3.7 6.9e-09 34.8 3.7 1.7 1 0 0 1 1 1 1 P53 transactivation motif DEC-1_N PF04625.11 NM_001126118.1_2 - 2.4 7.0 7.1 3.4 6.4 7.1 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region PARG_cat PF05028.12 NM_001303489.1_1 - 2.8e-134 447.5 0.0 3.5e-134 447.2 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Cadherin PF00028.15 NM_001167667.1_1 - 1.1e-73 243.6 6.1 1.8e-18 66.6 0.3 5.2 5 0 0 5 5 5 5 Cadherin domain Cadherin_3 PF16184.3 NM_001167667.1_1 - 5.1e-10 39.2 1.7 0.014 15.3 0.0 4.4 4 0 0 4 4 4 3 Cadherin-like Cadherin_2 PF08266.10 NM_001167667.1_1 - 0.00013 21.6 0.0 1.1 9.0 0.0 4.2 4 0 0 4 4 4 2 Cadherin-like Cadherin_C PF01049.15 NM_001167667.1_3 - 2.7e-52 176.4 0.9 4.3e-52 175.8 0.9 1.2 1 0 0 1 1 1 1 Cadherin cytoplasmic region ASFV_J13L PF05568.9 NM_001167667.1_3 - 0.094 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein zf-H2C2_2 PF13465.4 NM_001178099.1_3 - 7.4e-101 326.3 102.1 2e-08 34.1 0.3 15.8 16 0 0 16 16 15 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001178099.1_3 - 1.5e-85 277.0 100.2 2e-07 31.0 0.7 16.7 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001178099.1_3 - 5.9e-45 147.9 97.7 0.0015 19.1 0.4 16.6 16 0 0 16 16 16 14 C2H2-type zinc finger KRAB PF01352.25 NM_001178099.1_3 - 3e-25 87.5 0.8 6.6e-25 86.4 0.8 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001178099.1_3 - 6.8e-23 80.0 75.6 0.00086 19.1 0.3 14.9 14 0 0 14 14 14 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001178099.1_3 - 6.1e-11 42.2 72.0 0.037 14.2 0.5 13.9 13 1 1 14 14 14 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001178099.1_3 - 6.3e-08 32.5 78.4 0.013 15.5 1.3 9.5 4 3 4 10 10 9 7 Zinc ribbon domain C1_4 PF07975.10 NM_001178099.1_3 - 0.00021 21.3 59.7 0.072 13.2 3.5 10.4 4 2 6 11 11 11 4 TFIIH C1-like domain CpXC PF14353.4 NM_001178099.1_3 - 0.0011 18.9 49.4 7.7 6.4 0.6 13.2 8 4 2 10 10 10 1 CpXC protein DUF4934 PF16288.3 NM_001178099.1_3 - 0.044 13.6 14.1 11 5.9 0.2 6.0 4 3 2 6 6 6 0 Domain of unknown function (DUF4934) zinc_ribbon_15 PF17032.3 NM_001178099.1_3 - 0.054 14.1 65.7 0.53 10.9 0.2 8.4 2 1 5 8 8 7 0 zinc-ribbon family DUF3268 PF11672.6 NM_001178099.1_3 - 0.082 13.1 43.8 0.64 10.2 1.6 7.3 2 1 5 9 9 9 0 zinc-finger-containing domain C1_1 PF00130.20 NM_001178099.1_3 - 0.098 12.4 57.9 3.4 7.5 0.8 9.9 3 2 4 8 8 8 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-met PF12874.5 NM_001178099.1_3 - 0.34 11.2 77.2 0.15 12.4 1.9 12.1 12 0 0 12 12 12 0 Zinc-finger of C2H2 type DZR PF12773.5 NM_001178099.1_3 - 0.34 10.8 67.4 0.94 9.4 0.8 8.0 3 2 1 4 4 3 0 Double zinc ribbon ADK_lid PF05191.12 NM_001178099.1_3 - 5.1 7.1 33.5 0.65 9.9 1.6 7.4 7 1 0 7 7 7 0 Adenylate kinase, active site lid Myosin_head PF00063.19 NM_001127179.2_3 - 9.3e-241 800.6 0.4 1.2e-240 800.2 0.4 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.25 NM_001127179.2_3 - 1e-15 55.8 17.8 8e-06 25.1 0.1 4.8 4 0 0 4 4 4 4 IQ calmodulin-binding motif AAA_22 PF13401.4 NM_001127179.2_3 - 0.0059 16.7 1.1 0.072 13.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.4 NM_001127179.2_3 - 0.016 15.4 2.4 0.07 13.4 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.25 NM_001127179.2_3 - 0.079 13.3 1.5 0.17 12.3 0.0 2.2 2 0 0 2 2 2 0 ABC transporter Med17 PF10156.7 NM_001127179.2_3 - 1 7.8 10.6 1.6 7.2 10.6 1.2 1 0 0 1 1 1 0 Subunit 17 of Mediator complex MARVEL PF01284.21 NM_052886.2_1 - 2.3e-16 60.0 18.0 4.4e-16 59.1 18.0 1.5 1 0 0 1 1 1 1 Membrane-associating domain LRRC37AB_C PF14914.4 NM_001303255.1_2 - 8.4e-72 239.7 2.5 8.4e-72 239.7 2.5 2.3 2 0 0 2 2 2 1 LRRC37A/B like protein 1 C-terminal domain LRR_8 PF13855.4 NM_001303255.1_2 - 5.9e-11 41.8 1.4 5.9e-11 41.8 1.4 2.0 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.5 NM_001303255.1_2 - 6.6e-06 26.2 2.5 1.7e-05 24.9 0.2 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) CD34_antigen PF06365.10 NM_001303255.1_2 - 0.00017 21.1 0.4 0.00036 20.1 0.4 1.5 1 0 0 1 1 1 1 CD34/Podocalyxin family TMEM154 PF15102.4 NM_001303255.1_2 - 0.00083 19.1 0.0 0.0027 17.5 0.0 1.9 1 0 0 1 1 1 1 TMEM154 protein family Sarcoglycan_2 PF05510.11 NM_001303255.1_2 - 0.0085 14.8 0.0 0.015 14.0 0.0 1.2 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon LRR_9 PF14580.4 NM_001303255.1_2 - 0.026 13.9 0.0 0.062 12.7 0.0 1.6 1 0 0 1 1 1 0 Leucine-rich repeat Methuselah_N PF06652.10 NM_001303255.1_2 - 0.12 12.2 5.5 0.089 12.6 1.5 2.3 2 0 0 2 2 2 0 Methuselah N-terminus VWA_2 PF13519.4 NM_014173.3_1 - 0.043 14.4 0.0 0.066 13.8 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain SOG2 PF10428.7 NM_014173.3_1 - 0.19 10.8 1.5 0.24 10.5 1.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein WH1 PF00568.21 NM_000377.2_1 - 6.4e-43 145.1 0.0 8.6e-43 144.7 0.0 1.2 1 0 0 1 1 1 1 WH1 domain PBD PF00786.26 NM_000377.2_1 - 3.7e-17 62.3 0.0 9.5e-17 61.0 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain WH2 PF02205.18 NM_000377.2_1 - 7.9e-09 34.9 0.2 1.9e-08 33.8 0.2 1.7 1 0 0 1 1 1 1 WH2 motif UCH PF00443.27 NM_201402.2_1 - 2.6e-47 161.4 2.5 4.6e-46 157.3 0.7 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_201402.2_1 - 4.4e-18 65.8 1.9 8.6e-17 61.6 0.1 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase HABP4_PAI-RBP1 PF04774.13 NM_201402.2_1 - 0.00039 21.1 1.2 0.0009 19.9 1.2 1.6 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family LNS2 PF08235.11 NM_001261427.1_2 - 1e-103 345.5 0.0 1.7e-103 344.9 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 NM_001261427.1_2 - 7.7e-45 150.9 0.0 1.4e-44 150.1 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 NM_001261427.1_2 - 1.4e-32 111.7 0.0 2.8e-32 110.8 0.0 1.5 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.4 NM_001261427.1_2 - 0.026 15.3 1.6 0.07 13.9 1.6 1.8 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Ras PF00071.20 NM_021205.5_1 - 1.9e-48 164.0 0.0 2.8e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_021205.5_1 - 1.7e-19 70.1 0.0 2.9e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Lipase_GDSL_3 PF14606.4 NM_021205.5_1 - 0.19 11.7 0.0 0.3 11.0 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family MITF_TFEB_C_3_N PF15951.3 NM_001184968.1_1 - 1.1e-25 91.0 4.2 1.6e-25 90.4 4.2 1.2 1 0 0 1 1 1 1 MITF/TFEB/TFEC/TFE3 N-terminus LicD PF04991.11 NM_024301.4_1 - 1e-14 55.1 2.0 1.1e-11 45.2 0.8 2.1 2 0 0 2 2 2 2 LicD family Ets PF00178.20 NM_006874.3_3 - 3e-34 117.2 1.2 5.1e-34 116.5 1.2 1.4 1 0 0 1 1 1 1 Ets-domain Elf-1_N PF12310.6 NM_006874.3_3 - 3.7e-06 27.3 0.8 1.1e-05 25.8 0.1 2.1 2 0 0 2 2 2 1 Transcription factor protein N terminal Ras PF00071.20 NM_001278362.1_2 - 6.8e-44 149.2 0.0 8.8e-44 148.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001278362.1_2 - 1.1e-21 77.1 0.0 1.6e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001278362.1_2 - 4.8e-07 29.3 0.0 6.6e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001278362.1_2 - 0.047 13.6 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase UNC-93 PF05978.14 NM_001242536.1_2 - 7.1e-30 103.7 10.0 1.7e-29 102.4 10.0 1.7 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Ten_N PF06484.10 NM_001163279.1_2 - 1.4e-75 255.4 38.3 6.8e-45 154.4 18.5 2.3 1 1 1 2 2 2 2 Teneurin Intracellular Region Tox-GHH PF15636.4 NM_001163279.1_2 - 1.2e-28 98.6 1.2 2.4e-28 97.7 1.2 1.5 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin EGF_2 PF07974.11 NM_001163279.1_2 - 3.3e-16 59.2 152.8 0.00069 19.8 13.3 9.6 8 1 1 9 9 9 6 EGF-like domain RHS_repeat PF05593.12 NM_001163279.1_2 - 1e-09 38.5 29.5 0.0021 18.4 0.2 7.7 7 0 0 7 7 7 3 RHS Repeat NHL PF01436.19 NM_001163279.1_2 - 5.5e-07 29.2 2.7 0.061 13.3 0.0 5.6 4 0 0 4 4 4 1 NHL repeat SGL PF08450.10 NM_001163279.1_2 - 0.042 13.3 0.0 11 5.4 0.0 3.5 3 0 0 3 3 3 0 SMP-30/Gluconolaconase/LRE-like region RHS PF03527.12 NM_001163279.1_2 - 0.065 12.8 0.0 0.29 10.8 0.0 2.1 1 0 0 1 1 1 0 RHS protein SBBP PF06739.9 NM_001163279.1_2 - 0.09 12.7 0.0 0.29 11.0 0.0 1.9 1 0 0 1 1 1 0 Beta-propeller repeat Sec16_C PF12931.5 NM_033127.2_1 - 4.8e-47 161.0 0.0 9.2e-47 160.0 0.0 1.4 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.5 NM_033127.2_1 - 4.3e-06 27.2 0.0 1.2e-05 25.8 0.0 1.8 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region E7 PF00527.16 NM_033127.2_1 - 1 9.5 3.8 0.5 10.5 0.2 2.2 2 0 0 2 2 2 0 E7 protein, Early protein zf-H2C2_2 PF13465.4 NM_001204220.1_2 - 1.8e-52 173.4 100.1 2.4e-09 37.1 1.0 12.9 11 1 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001204220.1_2 - 3.4e-27 93.2 101.8 3.2e-05 24.0 0.8 12.1 12 0 0 12 12 12 9 Zinc finger, C2H2 type KRAB PF01352.25 NM_001204220.1_2 - 1.9e-24 84.9 0.1 3.4e-24 84.1 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001204220.1_2 - 2.6e-23 80.5 98.0 0.00085 19.8 0.8 12.1 12 0 0 12 12 12 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001204220.1_2 - 4.3e-11 42.3 93.8 7.3e-05 22.5 1.1 11.2 12 0 0 12 12 12 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001204220.1_2 - 0.025 14.7 0.1 0.025 14.7 0.1 10.6 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001204220.1_2 - 0.026 14.8 1.0 0.026 14.8 1.0 8.3 8 0 0 8 8 8 0 Zinc-finger of C2H2 type ANF_receptor PF01094.26 NM_002088.4_3 - 1.3e-56 192.1 0.0 1.7e-56 191.7 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 NM_002088.4_3 - 2.9e-48 163.3 0.1 4.7e-48 162.7 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_002088.4_3 - 2.9e-43 146.5 0.0 5.3e-43 145.7 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_002088.4_3 - 5.1e-18 65.2 0.0 8.6e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 NM_002088.4_3 - 0.13 11.8 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein Popeye PF04831.11 NM_152474.4_1 - 0.085 12.9 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Popeye protein conserved region V-set PF07686.15 NM_020219.3_1 - 2.6e-07 30.6 0.0 4.5e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Myosin_head PF00063.19 NM_138995.4_3 - 7.2e-206 685.3 0.5 9e-206 685.0 0.5 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Pkinase PF00069.23 NM_138995.4_3 - 1.8e-58 197.9 0.0 3.3e-58 197.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_138995.4_3 - 8.9e-42 143.0 0.0 1.5e-41 142.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_138995.4_3 - 1.7e-05 24.7 0.0 0.19 11.5 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family IQ PF00612.25 NM_138995.4_3 - 6.3e-05 22.3 0.2 6.3e-05 22.3 0.2 2.9 3 0 0 3 3 3 1 IQ calmodulin-binding motif Kinase-like PF14531.4 NM_138995.4_3 - 0.00032 20.0 0.0 0.00066 18.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like AAA_22 PF13401.4 NM_138995.4_3 - 0.011 15.9 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.18 NM_138995.4_3 - 0.11 12.2 0.0 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_16 PF13191.4 NM_138995.4_3 - 0.15 12.3 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain FOXP-CC PF16159.3 NM_001172767.2_2 - 2e-35 121.1 4.2 2e-35 121.1 4.2 5.0 3 1 2 5 5 2 1 FOXP coiled-coil domain PTPRCAP PF15713.3 NM_001172767.2_2 - 0.1 12.7 21.1 0.24 11.6 21.1 1.6 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Tim54 PF11711.6 NM_001172767.2_2 - 0.21 10.2 15.8 0.34 9.5 15.8 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 hDGE_amylase PF14701.4 NM_001172767.2_2 - 1.2 7.9 20.9 2.3 7.0 20.9 1.4 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Plasmodium_Vir PF05795.9 NM_001172767.2_2 - 1.9 7.7 15.8 7.2 5.8 13.8 2.5 2 1 0 2 2 2 0 Plasmodium vivax Vir protein ALMT PF11744.6 NM_001172767.2_2 - 1.9 7.1 30.1 5 5.7 30.1 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4746 PF15928.3 NM_001172767.2_2 - 3.2 7.0 17.4 5.6 6.2 17.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CobT PF06213.10 NM_001172767.2_2 - 3.2 6.9 38.5 0.9 8.7 35.4 1.6 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Membralin PF09746.7 NM_001172767.2_2 - 3.3 6.5 17.6 8.2 5.2 17.6 1.7 1 0 0 1 1 1 0 Tumour-associated protein TT_ORF1 PF02956.12 NM_001172767.2_2 - 3.4 6.1 25.0 5.2 5.5 25.0 1.2 1 0 0 1 1 1 0 TT viral orf 1 SpoIIP PF07454.9 NM_001172767.2_2 - 6 6.1 26.0 12 5.1 26.0 1.6 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.10 NM_001172767.2_2 - 6.8 6.3 29.7 19 4.9 29.7 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.4 NM_001172767.2_2 - 7.2 4.8 13.1 11 4.2 13.1 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Apt1 PF10351.7 NM_001172767.2_3 - 0.0039 16.0 14.1 0.0044 15.8 14.1 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain DUF1510 PF07423.9 NM_001172767.2_3 - 1.6 8.0 9.0 2.3 7.5 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TMEM154 PF15102.4 NM_001318204.1_1 - 0.24 11.2 0.0 0.37 10.5 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family Kringle PF00051.16 NM_001318204.1_2 - 1.4e-19 70.1 4.0 3e-19 69.0 4.0 1.6 1 0 0 1 1 1 1 Kringle domain I-set PF07679.14 NM_001318204.1_2 - 1.6e-18 66.4 0.0 2.4e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001318204.1_2 - 8.1e-16 58.3 0.0 1.6e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Fz PF01392.20 NM_001318204.1_2 - 2.7e-11 44.0 2.8 5.2e-11 43.1 2.8 1.5 1 0 0 1 1 1 1 Fz domain Ig_2 PF13895.4 NM_001318204.1_2 - 2.8e-09 37.1 0.5 7.2e-09 35.8 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 NM_001318204.1_2 - 5.8e-07 29.5 0.0 1.2e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 NM_001318204.1_2 - 2.1e-06 27.7 0.2 0.00052 20.0 0.2 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001318204.1_2 - 0.023 14.6 0.0 0.056 13.4 0.0 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 NM_001318204.1_2 - 0.096 13.0 0.0 0.32 11.3 0.0 1.9 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain COesterase PF00135.26 NM_018977.3_2 - 9.3e-196 651.6 0.0 1.1e-195 651.3 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 NM_018977.3_2 - 4.4e-05 23.3 0.1 0.00019 21.2 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Methyltransf_16 PF10294.7 NM_001302703.1_1 - 5.4e-17 61.9 0.0 7.6e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase BCOR PF15808.3 NM_017745.5_2 - 7.2e-74 248.6 17.7 7.2e-74 248.6 17.7 2.1 2 0 0 2 2 2 1 BCL-6 co-repressor, non-ankyrin-repeat region PUFD PF16553.3 NM_017745.5_2 - 2.9e-52 175.5 0.8 5.4e-52 174.6 0.8 1.5 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain Ank_2 PF12796.5 NM_017745.5_2 - 4.4e-16 59.1 0.6 2.3e-15 56.8 0.4 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_017745.5_2 - 1.7e-14 52.3 1.6 8.1e-05 22.6 0.2 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.4 NM_017745.5_2 - 5.6e-12 45.5 6.4 2.5e-09 37.1 0.1 3.9 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_017745.5_2 - 2.6e-11 43.7 7.3 1.5e-06 28.5 0.4 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_017745.5_2 - 9e-10 38.4 1.4 0.0016 18.7 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeat 7tm_1 PF00001.19 NM_138445.3_3 - 1.3e-12 47.4 3.5 2.1e-12 46.7 3.5 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rab5ip PF07019.10 NM_138445.3_3 - 0.11 13.0 2.3 0.12 12.8 0.3 2.2 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) 7tm_2 PF00002.22 NM_001289159.1_2 - 1.9e-57 194.3 20.8 3e-57 193.6 20.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 NM_001289159.1_2 - 1.3e-12 48.0 5.7 1.3e-12 48.0 5.7 2.9 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif MSC PF09402.8 NM_001289159.1_2 - 0.00012 21.6 1.2 0.00012 21.6 1.2 1.7 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain GAIN PF16489.3 NM_001289159.1_2 - 0.0017 17.7 0.0 0.0033 16.7 0.0 1.5 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain EGF_MSP1_1 PF12946.5 NM_001289159.1_2 - 0.019 14.9 4.1 0.039 13.9 4.1 1.5 1 0 0 1 1 1 0 MSP1 EGF domain 1 cEGF PF12662.5 NM_001289159.1_2 - 0.19 11.5 1.6 0.58 10.0 1.6 1.8 1 0 0 1 1 1 0 Complement Clr-like EGF-like XK-related PF09815.7 NM_018053.3_3 - 1e-89 300.7 22.3 1.3e-89 300.4 22.3 1.1 1 0 0 1 1 1 1 XK-related protein DBP PF12361.6 NM_001265578.1_1 - 0.51 9.8 7.8 0.73 9.3 7.8 1.2 1 0 0 1 1 1 0 Duffy-antigen binding protein TEX15 PF15326.4 NM_031271.3_1 - 5.5e-140 464.8 12.6 3.5e-131 435.9 1.9 4.1 4 0 0 4 4 4 2 Testis expressed sequence 15 Rabaptin PF03528.13 NM_001291581.1_3 - 1.7e-265 881.1 39.2 1.7e-265 881.1 39.2 3.0 2 1 0 3 3 3 1 Rabaptin Rab5-bind PF09311.9 NM_001291581.1_3 - 1.5e-138 461.3 60.1 1.5e-138 461.3 60.1 3.2 2 1 1 3 3 3 1 Rabaptin-like protein Fez1 PF06818.13 NM_001291581.1_3 - 0.004 17.5 24.0 0.004 17.5 24.0 5.2 2 2 3 5 5 5 2 Fez1 Fib_succ_major PF09603.8 NM_001291581.1_3 - 0.19 12.2 1.0 0.62 10.5 0.0 2.3 2 0 0 2 2 2 0 Fibrobacter succinogenes major domain (Fib_succ_major) ANAPC4_WD40 PF12894.5 NM_001320823.1_2 - 0.01 16.0 0.1 0.27 11.4 0.0 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 NM_001320823.1_2 - 0.13 13.1 3.8 6.4 7.7 0.0 4.2 5 0 0 5 5 5 0 WD domain, G-beta repeat DEAD PF00270.27 NM_001297757.1_2 - 6e-10 39.0 0.0 1e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001297757.1_3 - 4e-10 39.9 0.0 4.4e-09 36.6 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.4 NM_001297757.1_3 - 0.0022 18.4 0.0 0.0055 17.2 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF4332 PF14229.4 NM_001297757.1_3 - 0.0087 16.2 0.3 0.019 15.0 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) DNA_pol_lambd_f PF10391.7 NM_001297757.1_3 - 0.035 13.8 0.0 0.11 12.3 0.0 1.9 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda DNA_ligase_A_M PF01068.19 NM_013975.3_1 - 1.1e-61 207.9 0.0 1.8e-61 207.2 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 NM_013975.3_1 - 8.8e-34 117.2 0.1 2.4e-33 115.8 0.1 1.7 1 0 0 1 1 1 1 DNA ligase N terminus LIG3_BRCT PF16759.3 NM_013975.3_1 - 7.6e-27 93.3 0.0 1.8e-26 92.1 0.0 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain zf-PARP PF00645.16 NM_013975.3_1 - 1e-23 83.8 2.2 3.6e-23 82.1 2.2 2.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DNA_ligase_A_C PF04679.13 NM_013975.3_1 - 6.9e-19 68.2 0.0 1.5e-18 67.1 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.3 NM_013975.3_1 - 1.2e-06 28.7 0.0 3.6e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.8 NM_013975.3_1 - 3.5e-05 24.0 0.1 8.8e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 RNA ligase mRNA_cap_enzyme PF01331.17 NM_013975.3_1 - 0.047 13.4 0.1 0.13 12.0 0.1 1.8 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain HD_2 PF12917.5 NM_013975.3_1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme Herpes_capsid PF06112.9 NM_013975.3_1 - 8.4 6.3 12.6 0.62 10.0 5.5 2.2 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Dynein_IC2 PF11540.6 NM_001135557.1_2 - 1.1e-14 53.9 0.1 2.5e-14 52.8 0.1 1.7 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 NM_001135557.1_2 - 3e-06 27.7 8.3 0.17 12.7 0.3 6.0 7 0 0 7 7 7 2 WD domain, G-beta repeat RRM_3 PF08777.9 NM_016648.3_3 - 1.8e-29 101.6 0.0 1.8e-29 101.6 0.0 4.0 4 1 0 4 4 4 2 RNA binding motif La PF05383.15 NM_016648.3_3 - 6.4e-22 77.2 0.4 2.1e-21 75.6 0.0 2.1 2 0 0 2 2 2 1 La domain RRM_1 PF00076.20 NM_016648.3_3 - 5.6e-18 64.4 0.0 3.3e-16 58.7 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arm PF00514.21 NM_001904.3_2 - 1.5e-40 135.9 19.5 1.5e-07 31.1 0.1 11.7 13 0 0 13 13 13 7 Armadillo/beta-catenin-like repeat Cnd1 PF12717.5 NM_001904.3_2 - 2.4e-08 34.0 1.8 0.0059 16.5 0.3 4.3 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 NM_001904.3_2 - 8.1e-06 26.0 5.2 0.044 14.0 0.2 4.7 5 0 0 5 5 5 1 HEAT repeats Adaptin_N PF01602.18 NM_001904.3_2 - 1.1e-05 24.1 2.5 0.0016 17.0 1.0 3.0 3 0 0 3 3 3 1 Adaptin N terminal region HEAT_EZ PF13513.4 NM_001904.3_2 - 1.2e-05 25.6 6.9 1.8 9.0 0.0 6.1 5 1 1 6 6 6 2 HEAT-like repeat HEAT PF02985.20 NM_001904.3_2 - 1.5e-05 24.7 1.5 26 5.3 0.0 5.7 5 0 0 5 5 5 0 HEAT repeat Atx10homo_assoc PF09759.7 NM_001904.3_2 - 0.0027 17.6 1.2 0.019 14.9 0.2 2.9 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain DUF3361 PF11841.6 NM_001904.3_2 - 0.0044 16.8 1.9 3 7.6 0.0 4.3 2 1 1 4 4 4 1 Domain of unknown function (DUF3361) RasGEF_N_2 PF14663.4 NM_001904.3_2 - 0.0047 17.1 3.8 8.6 6.6 0.0 4.6 4 1 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Queuosine_synth PF02547.13 NM_001904.3_2 - 0.044 12.8 0.8 0.061 12.3 0.1 1.5 2 0 0 2 2 2 0 Queuosine biosynthesis protein Ig_2 PF13895.4 NM_001320608.1_1 - 1.4e-09 38.1 0.0 0.0029 17.8 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001320608.1_1 - 5.9e-06 26.7 0.4 0.021 15.3 0.2 3.0 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 NM_001320608.1_1 - 0.0038 17.1 0.1 13 5.8 0.0 3.6 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 NM_001320608.1_1 - 0.03 14.2 0.1 19 5.3 0.0 3.1 3 1 0 3 3 3 0 Immunoglobulin I-set domain ig PF00047.23 NM_001320608.1_1 - 0.073 13.1 0.3 10 6.2 0.1 3.8 4 0 0 4 4 4 0 Immunoglobulin domain ICAM_N PF03921.12 NM_001320608.1_2 - 5.5e-38 128.4 0.1 9e-38 127.7 0.1 1.3 1 0 0 1 1 1 1 Intercellular adhesion molecule (ICAM), N-terminal domain zf-H2C2_2 PF13465.4 NM_153257.4_2 - 1.6e-74 243.1 105.3 1.9e-08 34.2 1.1 14.6 13 1 0 13 13 13 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_153257.4_2 - 2.8e-40 134.4 125.4 4.2e-06 26.8 1.0 13.8 13 0 0 13 13 13 10 Zinc finger, C2H2 type KRAB PF01352.25 NM_153257.4_2 - 4.2e-24 83.8 0.3 8e-24 82.9 0.3 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_153257.4_2 - 1.5e-07 31.5 132.5 0.017 15.8 5.1 14.3 14 0 0 14 14 14 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_153257.4_2 - 4.4e-05 23.4 72.1 0.0047 16.9 3.7 8.3 4 2 5 9 9 9 7 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_153257.4_2 - 5.5e-05 22.9 97.4 0.0069 16.2 0.3 12.9 13 0 0 13 13 13 9 C2H2-type zinc finger BHD_1 PF10403.7 NM_153257.4_2 - 4.2 7.1 6.0 52 3.6 1.0 4.2 4 1 0 4 4 4 0 Rad4 beta-hairpin domain 1 APG5 PF04106.10 NM_001286106.1_3 - 1.8e-60 203.9 0.2 2.5e-60 203.5 0.2 1.2 1 0 0 1 1 1 1 Autophagy protein Apg5 TFIIS_C PF01096.16 NM_001278785.1_2 - 3.2e-15 55.6 4.9 3.2e-15 55.6 4.9 3.7 4 1 0 4 4 4 1 Transcription factor S-II (TFIIS) OrfB_Zn_ribbon PF07282.9 NM_001278785.1_2 - 0.0027 17.5 9.0 0.037 13.8 0.2 2.8 2 1 0 2 2 2 2 Putative transposase DNA-binding domain Zn_Tnp_IS1595 PF12760.5 NM_001278785.1_2 - 0.016 15.0 2.2 0.016 15.0 2.2 3.4 3 1 1 4 4 4 0 Transposase zinc-ribbon domain RNA_POL_M_15KD PF02150.14 NM_001278785.1_2 - 0.029 14.1 0.5 0.029 14.1 0.5 3.4 4 0 0 4 4 4 0 RNA polymerases M/15 Kd subunit DZR PF12773.5 NM_001278785.1_2 - 0.041 13.8 0.9 0.041 13.8 0.9 3.5 3 2 0 3 3 3 0 Double zinc ribbon Mu-like_Com PF10122.7 NM_001278785.1_2 - 0.044 13.1 3.5 2.8 7.3 0.3 2.6 2 0 0 2 2 2 0 Mu-like prophage protein Com IBR PF01485.19 NM_001278785.1_2 - 0.23 11.6 0.2 0.23 11.6 0.2 3.5 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain MqsA_antitoxin PF15731.3 NM_001278785.1_2 - 0.29 11.1 2.0 13 5.7 0.4 2.5 2 0 0 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA DNA_RNApol_7kD PF03604.11 NM_001278785.1_2 - 2.5 7.7 13.2 0.43 10.2 0.4 3.5 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_13 PF09855.7 NM_001278785.1_2 - 8.6 6.5 8.7 1.2e+02 2.8 0.1 3.5 2 1 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) THAP PF05485.10 NM_018105.2_1 - 1.9e-16 60.7 6.6 1.9e-16 60.7 6.6 2.1 2 0 0 2 2 2 1 THAP domain Cep57_CLD PF14073.4 NM_018105.2_1 - 7.4e-05 22.7 3.2 0.00012 22.1 3.2 1.2 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 Sec2p PF06428.9 NM_018105.2_1 - 0.0016 18.2 5.9 0.0026 17.5 5.9 1.3 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p MPS2 PF17060.3 NM_018105.2_1 - 0.012 14.7 3.3 0.019 14.1 3.3 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 ADIP PF11559.6 NM_018105.2_1 - 0.03 14.3 9.1 0.048 13.6 9.1 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4391 PF14335.4 NM_018105.2_1 - 0.041 13.5 1.9 0.058 13.0 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) PI3K_P85_iSH2 PF16454.3 NM_018105.2_1 - 0.056 12.9 9.6 0.084 12.3 9.6 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GrpE PF01025.17 NM_018105.2_1 - 0.21 11.1 4.9 0.34 10.4 4.9 1.2 1 0 0 1 1 1 0 GrpE FlaC_arch PF05377.9 NM_018105.2_1 - 0.27 11.5 2.0 0.45 10.8 2.0 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Macoilin PF09726.7 NM_018105.2_1 - 0.62 8.4 5.6 0.87 7.9 5.6 1.1 1 0 0 1 1 1 0 Transmembrane protein ABC_tran_Xtn PF12848.5 NM_018105.2_1 - 0.67 9.9 7.6 1.2 9.0 7.6 1.3 1 0 0 1 1 1 0 ABC transporter DivIC PF04977.13 NM_018105.2_1 - 1.1 8.9 6.3 2.1 8.1 6.3 1.4 1 0 0 1 1 1 0 Septum formation initiator IncA PF04156.12 NM_018105.2_1 - 1.2 8.8 5.2 1.7 8.2 5.2 1.1 1 0 0 1 1 1 0 IncA protein SlyX PF04102.10 NM_018105.2_1 - 9.6 6.8 9.3 41 4.8 7.7 2.0 1 1 0 1 1 1 0 SlyX V1R PF03402.12 NM_173857.2_1 - 2e-35 122.6 10.7 2.7e-35 122.2 10.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_173857.2_1 - 3.1e-13 49.4 10.6 3.6e-13 49.2 10.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TspO_MBR PF03073.13 NM_173857.2_1 - 0.013 15.4 0.5 0.013 15.4 0.5 2.7 2 2 0 2 2 2 0 TspO/MBR family PP_kinase PF02503.15 NM_173857.2_1 - 0.16 11.4 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Polyphosphate kinase middle domain OTT_1508_deam PF14441.4 NM_001244812.1_1 - 0.17 11.7 3.1 0.65 9.8 3.1 2.0 1 0 0 1 1 1 0 OTT_1508-like deaminase FOXP-CC PF16159.3 NM_001244812.1_2 - 6.8e-34 116.2 5.3 6.8e-34 116.2 5.3 2.9 2 1 1 3 3 3 1 FOXP coiled-coil domain Forkhead PF00250.16 NM_001244812.1_2 - 1.4e-27 95.7 0.2 2.4e-27 94.9 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain SURF4 PF02077.13 NM_001280788.1_2 - 4.1e-122 406.8 11.3 5.8e-122 406.3 11.3 1.1 1 0 0 1 1 1 1 SURF4 family DoxX PF07681.10 NM_001280788.1_2 - 0.064 13.7 14.6 0.096 13.2 0.2 3.2 3 1 0 3 3 3 0 DoxX LBP_BPI_CETP PF01273.23 NM_174932.2_1 - 4.4e-43 146.6 0.0 1e-42 145.4 0.0 1.6 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.15 NM_174932.2_1 - 5.4e-38 130.7 1.4 7.1e-38 130.2 1.4 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain RRM_1 PF00076.20 NM_001323970.1_3 - 2.5e-57 190.5 0.0 6.2e-21 73.9 0.0 4.3 3 1 1 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_001323970.1_3 - 3.6e-07 29.8 0.0 0.00028 20.5 0.0 2.9 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.3 NM_001323970.1_3 - 1.2e-05 25.2 0.1 1.1 9.2 0.0 3.8 3 1 0 3 3 3 2 RNA recognition motif Calcipressin PF04847.10 NM_001323970.1_3 - 0.023 14.3 0.0 2.1 7.9 0.0 2.5 2 0 0 2 2 2 0 Calcipressin PP2C_C PF07830.11 NM_177969.3_2 - 3.2e-32 110.6 0.1 5.2e-32 110.0 0.1 1.3 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain Kinesin PF00225.21 NM_001243953.1_3 - 9.8e-93 310.6 0.1 9.8e-93 310.6 0.1 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 NM_001243953.1_3 - 2.9e-14 53.1 0.3 9.5e-14 51.5 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding Paralemmin PF03285.13 NM_001037293.2_3 - 1.1e-107 360.2 16.8 2e-107 359.3 16.8 1.4 1 0 0 1 1 1 1 Paralemmin CALCOCO1 PF07888.9 NM_001037293.2_3 - 0.61 8.5 19.3 0.92 7.9 19.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like FlaC_arch PF05377.9 NM_001037293.2_3 - 2.9 8.2 5.8 6.6 7.1 5.8 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF4472 PF14739.4 NM_001037293.2_3 - 8.5 7.0 20.2 9.9 6.8 9.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) KRAB PF01352.25 NM_001289172.1_1 - 5.4e-20 70.7 0.3 8.2e-20 70.1 0.3 1.3 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 NM_001289172.1_2 - 1.1e-131 423.8 152.6 8.4e-09 35.4 0.3 20.8 20 1 1 21 21 20 19 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001289172.1_2 - 1.8e-89 289.4 136.6 2.1e-06 27.7 0.2 19.8 19 0 0 19 19 19 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001289172.1_2 - 2.8e-45 148.9 141.6 0.0041 17.7 0.3 20.2 21 0 0 21 21 19 17 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001289172.1_2 - 4.3e-22 77.7 71.1 0.27 11.5 0.1 17.8 18 0 0 18 18 18 9 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001289172.1_2 - 2.2e-12 46.7 100.3 0.029 14.3 2.2 13.1 4 2 13 17 17 17 13 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001289172.1_2 - 5.7e-12 45.2 118.6 0.017 14.9 0.5 19.5 20 0 0 20 20 20 11 C2H2-type zinc finger XPA_N PF01286.16 NM_001289172.1_2 - 5.3e-07 29.4 86.1 1.3 9.0 0.0 17.7 18 0 0 18 18 18 5 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001289172.1_2 - 8.8e-06 26.3 67.3 1.3 9.7 0.4 9.6 3 2 6 10 10 10 5 zinc-ribbon family zf-met PF12874.5 NM_001289172.1_2 - 2.7e-05 24.3 114.5 0.035 14.4 0.3 17.4 18 0 0 18 18 18 7 Zinc-finger of C2H2 type Herpes_ORF11 PF04797.11 NM_001289172.1_2 - 0.004 15.9 0.0 4.2 5.9 0.0 3.4 2 1 2 4 4 4 1 Herpesvirus dUTPase protein DUF3268 PF11672.6 NM_001289172.1_2 - 0.0048 17.1 59.4 0.22 11.7 1.0 8.7 3 2 2 9 9 9 5 zinc-finger-containing domain CpXC PF14353.4 NM_001289172.1_2 - 0.068 13.1 60.4 4.6 7.2 0.2 15.0 5 3 6 13 13 13 0 CpXC protein C1_4 PF07975.10 NM_001289172.1_2 - 0.082 13.0 78.9 1 9.5 2.2 12.8 1 1 9 13 13 13 0 TFIIH C1-like domain BolA PF01722.16 NM_001289172.1_2 - 0.68 10.1 28.3 2.5 8.3 0.4 7.1 5 3 1 6 6 6 0 BolA-like protein HypA PF01155.17 NM_001289172.1_2 - 2.4 8.1 63.2 1.8 8.5 1.3 9.8 1 1 8 9 9 8 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PFK PF00365.18 NM_001166688.1_3 - 2.4e-201 666.7 6.8 3.1e-109 364.5 0.8 2.1 2 0 0 2 2 2 2 Phosphofructokinase Phage_TAC_14 PF16462.3 NM_001166688.1_3 - 0.13 12.4 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC DED PF01335.19 NM_001306083.1_1 - 2e-40 136.8 16.2 3.3e-20 72.0 4.2 2.5 2 0 0 2 2 2 2 Death effector domain Imm30 PF15565.4 NM_001306083.1_1 - 0.011 15.7 0.1 0.033 14.1 0.1 1.8 1 1 0 1 1 1 0 Immunity protein 30 Voltage_CLC PF00654.18 NM_001171089.2_2 - 3.8e-93 312.4 26.4 3.8e-93 312.4 26.4 1.9 1 1 1 2 2 2 1 Voltage gated chloride channel CBM_5_12 PF02839.12 NM_007352.3_1 - 0.44 10.4 2.2 0.95 9.4 2.2 1.6 1 0 0 1 1 1 0 Carbohydrate binding domain Trypsin PF00089.24 NM_007352.3_3 - 6.3e-68 228.7 0.3 7.4e-68 228.5 0.3 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_007352.3_3 - 4.7e-06 27.4 0.2 9.9e-06 26.4 0.0 1.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain KLRAQ PF10205.7 NM_001282658.1_1 - 0.011 15.8 6.8 0.02 15.0 6.8 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein YscO PF07321.10 NM_001282658.1_1 - 0.021 14.6 7.9 0.034 14.0 7.9 1.2 1 0 0 1 1 1 0 Type III secretion protein YscO DUF972 PF06156.11 NM_001282658.1_1 - 0.045 14.2 0.9 0.084 13.4 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF489 PF04356.10 NM_001282658.1_1 - 0.048 13.5 1.1 0.074 12.9 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF489) DegS PF05384.9 NM_001282658.1_1 - 0.058 12.8 4.1 0.093 12.1 4.1 1.2 1 0 0 1 1 1 0 Sensor protein DegS DUF812 PF05667.9 NM_001282658.1_1 - 0.064 12.0 4.2 0.09 11.5 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Fib_alpha PF08702.8 NM_001282658.1_1 - 0.07 13.2 1.1 0.11 12.5 1.1 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.9 NM_001282658.1_1 - 0.13 12.5 0.8 0.26 11.6 0.8 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) P4Ha_N PF08336.9 NM_001282658.1_1 - 0.17 11.7 2.3 0.28 11.1 2.3 1.2 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Ax_dynein_light PF10211.7 NM_001282658.1_1 - 0.24 11.2 7.2 0.38 10.6 7.2 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain Herpes_UL6 PF01763.14 NM_001282658.1_1 - 0.34 9.2 1.5 0.48 8.7 1.5 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like DivIC PF04977.13 NM_001282658.1_1 - 0.42 10.3 5.9 0.73 9.5 5.9 1.3 1 0 0 1 1 1 0 Septum formation initiator ZapB PF06005.10 NM_001282658.1_1 - 0.82 10.0 7.8 1.7 9.0 7.8 1.4 1 0 0 1 1 1 0 Cell division protein ZapB TMF_DNA_bd PF12329.6 NM_001282658.1_1 - 2.7 7.9 8.8 4.4 7.2 8.8 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding IncA PF04156.12 NM_001282658.1_1 - 3.9 7.1 7.1 6.2 6.4 7.1 1.2 1 0 0 1 1 1 0 IncA protein GIT_CC PF16559.3 NM_001282658.1_1 - 6.6 6.7 6.3 3.1 7.8 0.6 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor RRM_1 PF00076.20 NM_006561.3_2 - 3.3e-49 164.4 0.0 4.8e-17 61.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 NM_006561.3_2 - 1.3e-07 31.4 0.0 0.63 10.0 0.0 3.5 3 0 0 3 3 3 3 RNA binding domain RRM_7 PF16367.3 NM_006561.3_2 - 0.0028 17.6 0.0 1.5 8.8 0.0 3.4 3 0 0 3 3 3 1 RNA recognition motif PHM7_cyt PF14703.4 NM_006561.3_2 - 0.11 12.6 0.7 4.8 7.3 0.0 2.9 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Tub PF01167.16 NM_003322.4_3 - 1.4e-80 269.9 0.0 2e-80 269.5 0.0 1.2 1 0 0 1 1 1 1 Tub family DUF3527 PF12043.6 NM_003322.4_3 - 0.15 11.5 0.7 0.69 9.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3527) DNA_pol_phi PF04931.11 NM_003322.4_3 - 4.5 5.1 7.5 8.6 4.2 7.5 1.3 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.8 NM_003322.4_3 - 5.5 7.3 10.1 13 6.1 10.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cnn_1N PF07989.9 NM_001080539.1_1 - 0.012 15.6 5.6 0.012 15.6 5.6 14.4 3 2 8 12 12 12 0 Centrosomin N-terminal motif 1 C2-set_2 PF08205.10 NM_001206936.1_2 - 2.2e-27 94.8 1.5 3.5e-23 81.4 0.0 3.4 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 NM_001206936.1_2 - 2.1e-19 69.8 0.1 5.5e-07 30.0 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_001206936.1_2 - 2.4e-14 53.3 0.0 4.2e-05 23.7 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 NM_001206936.1_2 - 8.1e-13 48.2 0.0 9.7e-05 22.3 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 NM_001206936.1_2 - 1.6e-12 47.2 0.0 0.00015 21.6 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.15 NM_001206936.1_2 - 1.2e-07 31.7 0.0 0.0055 16.7 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin V-set domain Calcipressin PF04847.10 NM_001251980.1_3 - 9.7e-54 181.8 1.3 1.7e-53 181.0 1.3 1.4 1 0 0 1 1 1 1 Calcipressin DOT1 PF08123.11 NM_032482.2_1 - 2e-82 275.6 0.0 3.1e-82 275.0 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Pkinase_Tyr PF07714.15 NM_001321357.1_2 - 2e-24 86.2 0.6 3.5e-24 85.4 0.6 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001321357.1_2 - 3.2e-24 85.6 1.3 6.4e-24 84.6 1.3 1.5 1 1 0 1 1 1 1 Protein kinase domain IL8 PF00048.18 NM_001291473.1_2 - 3e-09 36.7 0.1 3e-09 36.7 0.1 2.2 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.18 NM_001291473.1_3 - 3.8e-07 30.0 0.0 7.1e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Vinculin PF01044.17 NM_003373.3_2 - 0 1637.5 39.6 2.9e-297 988.9 15.5 2.3 2 1 1 3 3 3 2 Vinculin family LIM_bind PF01803.14 NM_003373.3_2 - 2.2 7.6 0.0 2.2 7.6 0.0 2.5 2 0 0 2 2 2 0 LIM-domain binding protein Connexin PF00029.17 NM_003373.3_2 - 5.9 6.5 17.5 11 5.5 17.5 1.4 1 0 0 1 1 1 0 Connexin Presenilin PF01080.15 NM_003373.3_2 - 7.5 5.1 11.5 16 4.0 11.5 1.5 1 0 0 1 1 1 0 Presenilin CSG2 PF16965.3 NM_003373.3_2 - 9.6 4.9 9.1 18 4.0 9.1 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator Pkinase PF00069.23 NM_033141.3_1 - 7.4e-64 215.5 0.0 1.1e-63 214.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_033141.3_1 - 9.2e-63 211.8 0.0 1.2e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SH3_9 PF14604.4 NM_033141.3_1 - 8.7e-13 47.8 0.1 2.6e-12 46.3 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 NM_033141.3_1 - 1.2e-10 40.7 0.0 2.4e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_033141.3_1 - 3.2e-10 39.4 0.0 6.4e-10 38.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain OmpH PF03938.12 NM_033141.3_1 - 1.2 8.9 5.0 2 8.3 5.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Ras PF00071.20 NM_032846.3_3 - 6e-61 204.6 0.1 7.9e-61 204.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_032846.3_3 - 6.2e-32 110.2 0.0 9.4e-32 109.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_032846.3_3 - 3e-11 43.0 0.0 4.4e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_032846.3_3 - 0.00061 19.7 0.0 0.00096 19.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_032846.3_3 - 0.0024 17.1 0.0 0.0036 16.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 NM_032846.3_3 - 0.055 12.9 0.0 0.14 11.6 0.0 1.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF258 PF03193.14 NM_032846.3_3 - 0.12 12.1 0.0 2.2 8.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 V-set PF07686.15 NM_001261457.1_1 - 3.3e-12 46.4 0.7 9.6e-05 22.4 0.0 3.3 3 1 0 4 4 4 2 Immunoglobulin V-set domain I-set PF07679.14 NM_001261457.1_1 - 1.8e-08 34.2 0.1 0.031 14.2 0.0 4.0 3 1 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001261457.1_1 - 3.2e-07 30.7 6.0 0.0044 17.5 0.9 4.4 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 NM_001261457.1_1 - 9.2e-07 28.8 2.3 0.009 16.0 0.0 4.8 4 1 0 4 4 4 2 Immunoglobulin domain Izumo-Ig PF16706.3 NM_001261457.1_1 - 0.073 13.0 0.0 18 5.4 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain HLH PF00010.24 NM_001243234.1_2 - 2.2e-11 43.4 1.0 5.3e-11 42.2 1.0 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 NM_001243234.1_2 - 4.7 5.3 10.0 7 4.7 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein RRM_1 PF00076.20 NM_003769.2_3 - 9.9e-33 111.7 0.0 2.7e-18 65.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 NM_003769.2_3 - 5.2e-05 23.0 0.0 0.0017 18.2 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.3 NM_003769.2_3 - 0.011 15.7 0.0 0.035 14.1 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif RRM_3 PF08777.9 NM_003769.2_3 - 0.11 12.4 0.0 0.11 12.4 0.0 2.5 3 0 0 3 3 3 0 RNA binding motif RRM_occluded PF16842.3 NM_003769.2_3 - 0.19 11.5 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif PH PF00169.27 NM_001323063.1_3 - 3.9e-09 36.8 0.2 7.1e-09 36.0 0.2 1.4 1 0 0 1 1 1 1 PH domain Sharpin_PH PF16764.3 NM_001323063.1_3 - 0.043 13.5 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 Sharpin PH domain Pkinase_Tyr PF07714.15 NM_001256793.1_1 - 3.5e-36 124.7 0.0 4.7e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001256793.1_1 - 3.4e-35 121.5 0.0 5e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 NM_001256793.1_1 - 4.7e-15 54.6 0.9 9.4e-15 53.7 0.9 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 NM_001256793.1_1 - 1.2e-12 48.6 10.7 3.1e-12 47.2 10.7 1.8 1 0 0 1 1 1 1 Activin types I and II receptor domain FTA2 PF13095.4 NM_001256793.1_1 - 0.043 13.3 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 TNF PF00229.16 NM_001204344.1_1 - 3.7e-38 130.2 0.0 6.5e-38 129.4 0.0 1.4 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family CH PF00307.29 NM_002670.2_2 - 1.7e-87 288.7 3.3 9e-26 90.1 0.1 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.30 NM_002670.2_2 - 2.5e-14 51.5 1.7 9.1e-07 27.9 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 NM_002670.2_2 - 4.9e-11 42.8 0.1 1.3e-10 41.5 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 NM_002670.2_2 - 8.6e-10 38.1 0.5 0.0001 21.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_002670.2_2 - 1.5e-09 36.9 0.1 0.00059 19.5 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 NM_002670.2_2 - 3e-08 32.7 8.8 5.9e-05 22.3 0.1 3.8 3 1 1 4 4 4 2 EF hand CAMSAP_CH PF11971.6 NM_002670.2_2 - 0.00025 20.7 0.1 0.011 15.4 0.1 2.7 2 0 0 2 2 2 1 CAMSAP CH domain SPARC_Ca_bdg PF10591.7 NM_002670.2_2 - 0.012 15.8 0.0 0.027 14.7 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Ribosomal_L7Ae PF01248.24 NM_001924.3_1 - 5.4e-17 61.2 0.0 8.4e-17 60.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family UQ_con PF00179.24 NM_003343.5_2 - 7.4e-47 158.4 0.0 1.1e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Trypsin_2 PF13365.4 NM_001297559.1_1 - 4.5e-30 105.4 0.0 7.5e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.24 NM_001297559.1_1 - 1.8e-13 50.7 0.0 2.7e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin Kazal_2 PF07648.13 NM_001297559.1_1 - 1.1e-09 38.2 0.9 2e-09 37.4 0.9 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain IGFBP PF00219.16 NM_001297559.1_1 - 2.5e-08 34.3 21.4 2.5e-08 34.3 21.4 2.2 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Kazal_1 PF00050.19 NM_001297559.1_1 - 0.00024 20.9 2.5 0.00024 20.9 2.5 1.8 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Peptidase_S46 PF10459.7 NM_001297559.1_1 - 0.00049 18.8 0.8 0.15 10.5 0.1 2.1 2 0 0 2 2 2 2 Peptidase S46 Peptidase_S32 PF05579.11 NM_001297559.1_1 - 0.006 15.7 0.1 1.4 8.0 0.0 2.1 2 0 0 2 2 2 2 Equine arteritis virus serine endopeptidase S32 zf-H2C2_2 PF13465.4 NM_015655.3_1 - 1.9e-97 315.5 123.9 4.3e-07 30.0 0.2 20.8 20 0 0 20 20 20 18 Zinc-finger double domain zf-C2H2 PF00096.24 NM_015655.3_1 - 5.8e-80 259.4 142.3 7.6e-06 26.0 2.6 20.2 20 0 0 20 20 20 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_015655.3_1 - 3.4e-55 179.7 140.2 0.00078 19.9 0.9 20.6 20 0 0 20 20 20 19 C2H2-type zinc finger KRAB PF01352.25 NM_015655.3_1 - 1.4e-21 75.8 0.3 3.1e-21 74.6 0.0 1.7 2 0 0 2 2 2 1 KRAB box zf-C2H2_jaz PF12171.6 NM_015655.3_1 - 1.2e-18 66.8 69.0 0.057 13.6 0.5 15.9 17 0 0 17 17 16 9 Zinc-finger double-stranded RNA-binding ADK_lid PF05191.12 NM_015655.3_1 - 8.2e-08 32.0 54.9 0.26 11.2 0.3 12.6 8 5 4 12 12 12 5 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 NM_015655.3_1 - 2.9e-07 30.3 79.9 0.1 12.6 2.4 11.9 7 2 4 12 12 12 8 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_015655.3_1 - 1.6e-06 28.7 63.0 1.7 9.3 1.5 9.8 1 1 6 8 8 8 4 zinc-ribbon family zf-trcl PF13451.4 NM_015655.3_1 - 1.1e-05 25.0 82.2 1.5 8.6 1.7 17.2 16 2 0 16 16 16 5 Probable zinc-ribbon domain zf-C2H2_11 PF16622.3 NM_015655.3_1 - 4.1e-05 23.1 94.7 0.052 13.2 0.9 17.1 18 0 0 18 18 18 7 zinc-finger C2H2-type DUF3268 PF11672.6 NM_015655.3_1 - 0.0045 17.2 53.2 1 9.6 0.0 10.0 4 2 6 13 13 13 3 zinc-finger-containing domain zf-met PF12874.5 NM_015655.3_1 - 0.71 10.2 89.0 0.31 11.3 1.1 14.3 15 0 0 15 15 15 0 Zinc-finger of C2H2 type CpXC PF14353.4 NM_015655.3_1 - 1.2 9.1 53.5 20 5.1 0.1 13.4 7 5 6 15 15 15 0 CpXC protein Yippee-Mis18 PF03226.12 NM_015655.3_1 - 4.1 7.5 45.6 1.4 9.0 0.3 6.6 4 2 2 7 7 7 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly TLV_coat PF00429.17 NM_001007253.3_1 - 2.6e-10 39.5 1.6 3.3e-09 35.9 1.6 2.2 1 1 0 1 1 1 1 ENV polyprotein (coat polyprotein) Myb_DNA-bind_5 PF13873.4 NM_001318748.1_2 - 6.3e-23 80.5 6.0 1.7e-22 79.2 6.0 1.8 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain zinc_ribbon_12 PF11331.6 NM_000042.2_1 - 0.82 9.4 7.8 5 6.9 0.4 3.3 3 0 0 3 3 3 0 Probable zinc-ribbon domain Sushi PF00084.18 NM_000042.2_3 - 2.8e-43 146.2 26.5 6.1e-12 45.9 0.7 5.2 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) Sushi_2 PF09014.8 NM_000042.2_3 - 8.9e-36 121.6 5.5 2.1e-35 120.5 5.5 1.7 1 0 0 1 1 1 1 Beta-2-glycoprotein-1 fifth domain cEGF PF12662.5 NM_000042.2_3 - 0.022 14.5 9.0 9.8 6.1 0.2 4.5 3 0 0 3 3 3 0 Complement Clr-like EGF-like DUF842 PF05811.11 NM_000042.2_3 - 0.11 12.2 2.0 0.17 11.6 2.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) HRM PF02793.20 NM_000042.2_3 - 1.5 9.1 12.2 3.5 7.9 0.1 3.9 4 0 0 4 4 4 0 Hormone receptor domain zf-LITAF-like PF10601.7 NM_013399.2_3 - 1.2e-21 76.6 13.9 1.2e-21 76.6 13.9 3.1 4 0 0 4 4 4 1 LITAF-like zinc ribbon domain I-set PF07679.14 NM_001290040.1_2 - 1.2e-86 284.7 0.0 5.3e-21 74.4 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001290040.1_2 - 1.3e-80 265.8 3.2 1e-15 57.9 0.0 6.3 6 0 0 6 6 6 5 Immunoglobulin domain Ig_2 PF13895.4 NM_001290040.1_2 - 8.7e-53 176.5 0.1 7.1e-10 39.0 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 NM_001290040.1_2 - 2.2e-50 168.6 0.0 7.9e-10 38.6 0.0 5.9 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.19 NM_001290040.1_2 - 2.5e-34 117.3 10.4 2.2e-13 50.2 0.9 3.8 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.15 NM_001290040.1_2 - 2.3e-30 104.8 5.4 3.1e-07 30.4 0.0 8.3 5 4 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001290040.1_2 - 2.8e-10 40.0 1.2 0.019 14.9 0.0 5.7 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 NM_001290040.1_2 - 1.8e-06 28.1 0.0 0.29 11.4 0.0 5.0 5 0 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR1 PF02440.13 NM_001290040.1_2 - 0.085 12.5 0.0 0.67 9.6 0.0 2.6 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 NUDIX PF00293.26 NM_014142.3_3 - 2.4e-14 53.4 0.0 5e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain SH3BP5 PF05276.12 NM_004844.4_3 - 2.2e-92 309.0 21.4 2.8e-92 308.6 21.4 1.1 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) DUF1068 PF06364.10 NM_004844.4_3 - 2.2 8.0 7.7 0.6 9.8 3.9 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1068) tRNA-synt_His PF13393.4 NM_002109.5_1 - 1e-40 139.8 0.0 2e-40 138.9 0.0 1.5 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.18 NM_002109.5_1 - 2.6e-17 62.6 0.9 5.3e-17 61.6 0.9 1.5 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.5 NM_002109.5_1 - 2e-11 43.7 0.3 3.4e-11 42.9 0.3 1.3 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs WHEP-TRS PF00458.18 NM_002109.5_1 - 3.5e-10 39.8 5.2 1e-09 38.3 5.2 1.8 1 0 0 1 1 1 1 WHEP-TRS domain HHH_3 PF12836.5 NM_002109.5_1 - 0.021 15.0 0.0 0.054 13.6 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Virul_Fac PF10139.7 NM_002109.5_1 - 0.11 10.6 0.0 0.16 10.0 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor FAM176 PF14851.4 NM_001304762.1_2 - 2.1e-53 179.7 0.0 2.9e-53 179.3 0.0 1.1 1 0 0 1 1 1 1 FAM176 family 7tm_2 PF00002.22 NM_001308418.1_1 - 8.3e-82 274.0 8.0 1.1e-81 273.6 8.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_001308418.1_1 - 0.057 13.6 0.5 0.14 12.3 0.5 1.7 1 0 0 1 1 1 0 Hormone receptor domain C2 PF00168.28 NM_001130982.1_1 - 6.3e-101 331.4 0.0 1.5e-19 70.1 0.0 8.4 7 1 0 7 7 7 7 C2 domain FerB PF08150.10 NM_001130982.1_1 - 1.9e-30 105.2 0.1 4.9e-30 103.8 0.1 1.8 1 0 0 1 1 1 1 FerB (NUC096) domain Ferlin_C PF16165.3 NM_001130982.1_1 - 4.5e-27 94.8 1.7 3e-23 82.3 0.0 2.8 2 1 1 3 3 3 2 Ferlin C-terminus FerA PF08165.9 NM_001130982.1_1 - 8.1e-20 70.4 0.2 1.7e-19 69.4 0.2 1.6 1 0 0 1 1 1 1 FerA (NUC095) domain FerI PF08151.10 NM_001130982.1_1 - 2.2e-18 66.0 0.1 5.2e-18 64.8 0.1 1.7 1 0 0 1 1 1 1 FerI (NUC094) domain Pex24p PF06398.9 NM_001130982.1_1 - 5.1e-06 25.6 8.4 5.1e-06 25.6 8.4 3.6 3 1 1 4 4 4 1 Integral peroxisomal membrane peroxin PTEN_C2 PF10409.7 NM_001130982.1_1 - 0.0046 16.6 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein PI3K_C2 PF00792.22 NM_001130982.1_1 - 0.14 12.1 0.0 41 4.1 0.0 3.3 3 0 0 3 3 3 0 Phosphoinositide 3-kinase C2 Sigma_reg_N PF13800.4 NM_001130982.1_1 - 3.6 7.8 4.1 8 6.7 4.1 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Homeobox PF00046.27 NM_153426.2_3 - 4e-22 77.6 9.2 7.3e-22 76.8 9.2 1.4 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 NM_153426.2_3 - 7.6e-08 31.8 1.1 7.6e-08 31.8 1.1 1.9 2 0 0 2 2 2 1 OAR domain Homeobox_KN PF05920.9 NM_153426.2_3 - 0.0064 16.2 0.6 0.019 14.7 0.6 1.8 1 0 0 1 1 1 1 Homeobox KN domain XRCC4 PF06632.10 NM_153426.2_3 - 0.018 13.8 4.5 0.029 13.1 4.5 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Auxin_canalis PF05703.9 NM_153426.2_3 - 4.3 7.1 5.2 7.4 6.3 5.2 1.3 1 0 0 1 1 1 0 Auxin canalisation CCDC71L PF15374.4 NM_022903.3_1 - 2.1e-182 606.6 45.9 4.2e-139 464.0 19.7 3.0 2 1 1 3 3 3 2 Coiled-coil domain-containing protein 71L Lectin_C PF00059.19 NM_001320814.1_2 - 9.1e-23 80.9 0.0 1.7e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 NM_001320814.1_2 - 5.5e-10 38.7 34.7 2.1e-05 24.0 15.1 2.4 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) IQ PF00612.25 NM_001287501.1_3 - 9.5e-11 40.4 2.9 0.0019 17.7 0.0 3.8 3 0 0 3 3 3 3 IQ calmodulin-binding motif CHD5 PF04420.12 NM_001287501.1_3 - 0.24 11.1 0.7 0.84 9.3 0.7 1.9 1 0 0 1 1 1 0 CHD5-like protein Ribosomal_L15e PF00827.15 NM_001253383.1_1 - 8e-97 322.4 3.4 1e-96 322.1 3.4 1.1 1 0 0 1 1 1 1 Ribosomal L15 Folate_carrier PF01770.16 NM_194255.2_1 - 2.7e-169 563.1 9.5 3.3e-169 562.9 9.5 1.0 1 0 0 1 1 1 1 Reduced folate carrier PH PF00169.27 NM_025201.4_3 - 1.2e-11 44.9 0.1 1.9e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_025201.4_3 - 0.019 15.3 0.1 0.049 13.9 0.1 1.6 1 1 0 1 1 1 0 Pleckstrin homology domain Ion_trans PF00520.29 NM_017636.3_1 - 9.6e-13 47.8 7.0 3.1e-12 46.1 7.0 1.8 1 1 0 1 1 1 1 Ion transport protein UCH PF00443.27 NM_201626.2_3 - 3.2e-64 216.8 0.0 2.2e-63 214.1 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_201626.2_3 - 2.4e-33 115.9 3.9 8.4e-22 78.0 0.0 2.3 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 NM_201626.2_3 - 2.3e-16 59.7 8.4 2.3e-16 59.7 8.4 3.4 5 0 0 5 5 5 1 Zn-finger in ubiquitin-hydrolases and other protein DUSP PF06337.10 NM_201626.2_3 - 1.1e-07 32.2 0.0 5.2e-07 30.1 0.0 2.2 1 0 0 1 1 1 1 DUSP domain UQ_con PF00179.24 NM_022442.5_1 - 8.5e-11 41.5 0.1 1.4e-10 40.8 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Aldo_ket_red PF00248.19 NM_001818.3_1 - 2.3e-54 184.4 0.0 2.7e-54 184.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family AIG2_2 PF13772.4 NM_001199816.1_1 - 0.032 14.5 0.1 0.049 13.9 0.1 1.2 1 0 0 1 1 1 0 AIG2-like family GGACT PF06094.10 NM_001199816.1_1 - 0.058 13.9 0.0 0.087 13.3 0.0 1.2 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like SPATA3 PF15662.3 NM_139073.3_3 - 1.8e-95 318.9 31.3 1.8e-95 318.9 31.3 2.0 2 0 0 2 2 2 1 Spermatogenesis-associated protein 3 family Trypan_PARP PF05887.9 NM_139073.3_3 - 0.17 11.8 3.0 0.28 11.1 3.0 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Ins145_P3_rec PF08709.9 NM_001099952.2_3 - 1.1e-94 315.4 0.0 6.5e-94 312.9 0.0 2.1 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RYDR_ITPR PF01365.19 NM_001099952.2_3 - 5.3e-72 241.4 22.7 2.4e-61 206.6 0.6 4.7 5 0 0 5 5 5 2 RIH domain MIR PF02815.17 NM_001099952.2_3 - 1.4e-71 240.1 0.1 2e-68 229.8 0.0 2.5 2 0 0 2 2 2 2 MIR domain RIH_assoc PF08454.9 NM_001099952.2_3 - 3.1e-31 107.1 7.1 3.1e-31 107.1 7.1 5.6 6 1 0 6 6 6 2 RyR and IP3R Homology associated Ion_trans PF00520.29 NM_001099952.2_3 - 2.4e-19 69.4 7.0 2.4e-19 69.4 7.0 1.8 2 0 0 2 2 2 1 Ion transport protein MscS_porin PF12795.5 NM_001099952.2_3 - 0.023 14.1 2.1 0.095 12.1 2.1 2.0 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Sec2p PF06428.9 NM_001099952.2_3 - 0.29 11.0 5.3 1.8 8.4 5.3 2.4 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p Pkinase PF00069.23 NM_170663.4_2 - 9.1e-62 208.7 1.1 6.2e-61 205.9 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain CNH PF00780.20 NM_170663.4_2 - 6.5e-58 196.4 0.0 9.8e-58 195.8 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 NM_170663.4_2 - 1.3e-45 155.6 0.0 2.7e-45 154.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PTN_MK_C PF01091.16 NM_001321386.1_1 - 2.3e-26 91.8 9.1 2.3e-26 91.8 9.1 2.9 3 1 0 3 3 3 1 PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N PF05196.11 NM_001321386.1_1 - 1.3e-25 89.2 15.4 1.3e-25 89.2 15.4 2.3 3 1 0 3 3 3 1 PTN/MK heparin-binding protein family, N-terminal domain VWA PF00092.26 NM_001286375.1_2 - 5.3e-42 143.9 0.7 8.3e-42 143.3 0.7 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_alpha2 PF08441.10 NM_001286375.1_2 - 8.3e-39 133.6 0.0 1.2e-38 133.1 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 NM_001286375.1_2 - 3.6e-21 74.8 4.7 1e-07 31.8 0.6 3.8 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 NM_001286375.1_2 - 6.6e-15 55.6 0.2 1.6e-14 54.3 0.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 NM_001286375.1_2 - 4.2e-06 27.1 0.0 0.063 13.7 0.1 3.5 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 NM_001286375.1_2 - 6.6e-06 25.6 0.9 1.7e-05 24.3 0.9 1.8 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region VWA_CoxE PF05762.12 NM_001286375.1_2 - 0.00031 20.1 0.2 0.00054 19.3 0.2 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein FG-GAP_2 PF14312.4 NM_001286375.1_2 - 0.37 10.9 11.3 0.55 10.4 0.1 3.8 4 0 0 4 4 4 0 FG-GAP repeat GKAP PF03359.11 NM_183006.3_1 - 7.3e-149 495.9 6.5 7.3e-149 495.9 6.5 1.8 2 0 0 2 2 2 1 Guanylate-kinase-associated protein (GKAP) protein CDKN3 PF05706.10 NM_001130851.1_1 - 9.7e-81 269.2 5.1 1e-80 269.1 3.6 1.6 1 1 1 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.25 NM_001130851.1_1 - 2e-05 24.2 0.0 2.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 NM_001130851.1_1 - 2.6e-05 23.9 0.0 4.3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Prefoldin PF02996.15 NM_002624.3_1 - 1.6e-28 98.9 3.4 3.1e-28 98.0 3.4 1.4 1 0 0 1 1 1 1 Prefoldin subunit DUF1795 PF08786.9 NM_002624.3_1 - 0.014 15.3 2.7 0.11 12.4 0.1 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF1795) ING PF12998.5 NM_002624.3_1 - 0.042 14.3 1.2 0.042 14.3 1.2 2.3 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding zf-H2C2_2 PF13465.4 NM_030634.2_1 - 1.9e-86 280.8 88.3 7.8e-09 35.5 1.3 13.8 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_030634.2_1 - 6.1e-71 231.0 99.6 4.7e-07 29.8 1.9 13.3 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_030634.2_1 - 1.6e-35 118.5 101.0 0.001 19.6 0.4 13.3 13 0 0 13 13 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_030634.2_1 - 2.2e-23 81.6 84.0 5e-05 23.0 0.4 12.7 12 0 0 12 12 12 12 C2H2-type zinc finger KRAB PF01352.25 NM_030634.2_1 - 3.1e-22 77.8 0.2 7.2e-22 76.7 0.2 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_030634.2_1 - 1.6e-10 40.9 66.8 0.059 13.6 0.1 12.6 13 0 0 13 13 13 7 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_030634.2_1 - 2.8e-08 33.6 62.4 0.0045 17.0 1.9 8.0 6 3 2 8 8 8 7 Zinc ribbon domain XPA_N PF01286.16 NM_030634.2_1 - 4.1e-06 26.6 45.3 3.3 7.7 0.3 11.9 12 0 0 12 12 12 3 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_030634.2_1 - 0.00035 21.1 45.3 0.22 12.2 1.1 6.6 1 1 5 6 6 6 3 zinc-ribbon family zf-met PF12874.5 NM_030634.2_1 - 0.23 11.8 92.6 0.022 15.0 1.6 11.8 12 0 0 12 12 12 0 Zinc-finger of C2H2 type HTH_18 PF12833.5 NM_030634.2_1 - 4.1 7.6 7.7 83 3.4 0.0 5.6 7 2 0 7 7 7 0 Helix-turn-helix domain Pkinase PF00069.23 NM_001323327.1_1 - 6e-62 209.3 0.0 7.7e-62 208.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001323327.1_1 - 7.1e-28 97.5 0.0 9.9e-28 97.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_001323327.1_1 - 2.4e-06 26.9 0.2 3.7e-06 26.3 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_001323327.1_1 - 0.00033 19.9 0.0 0.00051 19.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 NM_001323327.1_1 - 0.0049 16.4 0.4 0.0081 15.6 0.4 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 NM_001323327.1_1 - 0.005 16.7 0.0 0.0079 16.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Homeobox_KN PF05920.9 NM_001323327.1_2 - 0.12 12.1 0.1 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 Homeobox KN domain Calcipressin PF04847.10 NM_001251984.1_3 - 3.2e-59 199.7 0.4 4.7e-59 199.1 0.4 1.2 1 0 0 1 1 1 1 Calcipressin UDPGT PF00201.16 NM_001301233.1_3 - 3.1e-198 659.5 0.0 3.2e-116 388.9 0.8 2.0 1 1 1 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 NM_001301233.1_3 - 4.5e-06 26.6 0.0 7.4e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pro_3_hydrox_C PF05373.9 NM_001301233.1_3 - 0.042 13.8 0.1 0.081 12.9 0.1 1.4 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal Glyco_transf_4 PF13439.4 NM_001301233.1_3 - 0.068 13.0 0.0 0.64 9.9 0.0 2.1 1 1 0 1 1 1 0 Glycosyltransferase Family 4 CAAP1 PF15335.4 NM_001167575.1_1 - 3.9e-27 94.4 10.2 6.2e-27 93.8 10.2 1.3 1 0 0 1 1 1 1 Caspase activity and apoptosis inhibitor 1 Lectin_N PF03954.12 NM_001197216.2_2 - 6.4e-34 116.4 5.4 1e-33 115.7 5.4 1.3 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain Lectin_C PF00059.19 NM_001197216.2_2 - 4.8e-24 85.0 1.0 8.2e-24 84.3 1.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain AIP3 PF03915.11 NM_001197216.2_2 - 0.0058 15.6 1.5 0.0076 15.2 1.5 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 Tropomyosin_1 PF12718.5 NM_001197216.2_2 - 0.011 15.7 4.5 0.018 15.1 4.5 1.2 1 0 0 1 1 1 0 Tropomyosin like Jnk-SapK_ap_N PF09744.7 NM_001197216.2_2 - 0.061 13.4 5.4 0.091 12.9 5.4 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 IFT57 PF10498.7 NM_001197216.2_2 - 0.088 11.6 2.4 0.12 11.2 2.4 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Cluap1 PF10234.7 NM_001197216.2_2 - 0.16 11.2 2.0 0.21 10.8 2.0 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 APG6 PF04111.10 NM_001197216.2_2 - 0.29 10.3 3.2 0.42 9.8 3.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 LMBR1 PF04791.14 NM_018368.3_1 - 1.2e-27 96.9 19.4 1.6e-25 89.8 19.4 2.1 1 1 0 1 1 1 1 LMBR1-like membrane protein Wbp11 PF09429.8 NM_018368.3_1 - 0.065 13.5 2.4 0.11 12.8 2.4 1.3 1 0 0 1 1 1 0 WW domain binding protein 11 DUF1772 PF08592.9 NM_018368.3_1 - 8.6 6.6 16.6 28 4.9 2.0 4.1 2 2 0 3 3 3 0 Domain of unknown function (DUF1772) DUF1980 PF09323.8 NM_018368.3_1 - 8.7 6.1 10.6 8.7 6.1 0.3 3.8 2 2 2 4 4 4 0 Domain of unknown function (DUF1980) SelP_N PF04592.12 NM_001093726.1_3 - 1.5e-104 348.4 5.0 1.5e-104 348.4 5.0 1.9 2 1 1 3 3 3 2 Selenoprotein P, N terminal region SelP_C PF04593.12 NM_001093726.1_3 - 3.2e-40 137.1 11.0 3.2e-40 137.1 11.0 1.8 2 0 0 2 2 2 1 Selenoprotein P, C terminal region CENP-U PF13097.4 NM_024629.3_2 - 9.2e-71 237.4 20.5 2.8e-70 235.8 20.5 1.9 1 0 0 1 1 1 1 CENP-A nucleosome associated complex (NAC) subunit bZIP_2 PF07716.13 NM_024629.3_2 - 1.8 8.6 12.1 0.59 10.1 7.1 2.8 2 0 0 2 2 2 0 Basic region leucine zipper HRM PF02793.20 NM_001303020.1_2 - 4.7e-09 36.3 0.2 1.4e-08 34.7 0.2 1.8 1 0 0 1 1 1 1 Hormone receptor domain 7tm_2 PF00002.22 NM_001303020.1_3 - 4e-78 262.0 19.3 4.9e-78 261.7 19.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) PBC PF03792.11 NM_001134778.1_1 - 2.2e-83 278.6 0.0 3.8e-83 277.8 0.0 1.3 1 0 0 1 1 1 1 PBC domain Homeobox PF00046.27 NM_001134778.1_1 - 1e-18 66.7 1.2 1.9e-18 65.9 1.2 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_001134778.1_1 - 2.8e-15 55.8 0.0 1.2e-14 53.8 0.0 2.0 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.3 NM_001134778.1_1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Stathmin PF00836.17 NM_001283054.1_3 - 5.9e-58 194.5 19.2 9.1e-58 193.9 19.2 1.3 1 0 0 1 1 1 1 Stathmin family NADH5_C PF06455.9 NM_001283054.1_3 - 0.15 11.5 0.1 0.24 10.8 0.1 1.2 1 0 0 1 1 1 0 NADH dehydrogenase subunit 5 C-terminus Ribosomal_60s PF00428.17 NM_001320592.1_1 - 1.5 9.3 8.5 2.3 8.7 8.5 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Aldolase_II PF00596.19 NM_001320592.1_3 - 5.5e-39 133.9 0.1 7.8e-39 133.4 0.1 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Epimerase PF01370.19 NM_003313.3_2 - 4.1e-58 196.6 0.0 5.5e-58 196.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 NM_003313.3_2 - 5.4e-14 52.2 0.5 1.2e-13 51.0 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.15 NM_003313.3_2 - 2.5e-07 29.9 0.1 7.1e-07 28.5 0.1 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.13 NM_003313.3_2 - 0.001 18.1 2.3 0.011 14.7 0.0 2.7 3 0 0 3 3 3 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.17 NM_003313.3_2 - 0.002 17.0 0.3 0.023 13.5 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NICE-3 PF07406.9 NM_003313.3_2 - 0.003 17.4 0.0 0.0047 16.8 0.0 1.3 1 0 0 1 1 1 1 NICE-3 protein RRM_1 PF00076.20 NM_001191005.2_2 - 2e-18 65.9 0.0 3.5e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 NM_001191005.2_2 - 0.00036 20.3 0.0 0.00073 19.3 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif BK_channel_a PF03493.16 NM_001322835.1_1 - 3.2e-32 110.5 0.2 6.2e-32 109.6 0.2 1.5 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.29 NM_001322835.1_1 - 3.5e-17 62.3 20.1 7.7e-17 61.2 20.1 1.5 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 NM_001322835.1_1 - 2.9e-13 49.5 4.1 2.9e-13 49.5 4.1 2.2 2 0 0 2 2 2 1 Ion channel TrkA_N PF02254.16 NM_001322835.1_1 - 0.00021 21.4 0.0 0.00063 19.9 0.0 1.7 2 0 0 2 2 2 1 TrkA-N domain zf-DHHC PF01529.18 NM_001135179.1_2 - 5.9e-36 123.4 13.7 1.7e-35 121.9 13.7 1.8 1 0 0 1 1 1 1 DHHC palmitoyltransferase VHS PF00790.17 NM_001172703.2_1 - 5.7e-46 155.8 1.2 1.2e-45 154.7 0.0 1.9 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.18 NM_001172703.2_1 - 2.3e-27 95.3 0.0 4.1e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.12 NM_001172703.2_1 - 2.4e-18 66.1 2.3 2.4e-18 66.1 2.3 2.3 2 0 0 2 2 2 1 GAT domain HBM PF16591.3 NM_001172703.2_1 - 0.13 11.5 2.2 0.21 10.9 2.2 1.2 1 0 0 1 1 1 0 Helical bimodular sensor domain RapA_C PF12137.6 NM_001172703.2_1 - 0.16 10.8 1.3 0.26 10.1 1.3 1.3 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal Bombesin PF02044.15 NM_001012512.2_3 - 2.6e-08 33.2 5.0 5.8e-08 32.1 5.0 1.6 1 0 0 1 1 1 1 Bombesin-like peptide Ski_Sno PF02437.15 NM_005414.4_2 - 5.8e-43 144.9 1.8 1.2e-42 143.9 1.8 1.5 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.8 NM_005414.4_2 - 1.1e-35 121.7 5.1 1.1e-35 121.7 5.1 2.0 2 0 0 2 2 2 1 c-SKI Smad4 binding domain DUF489 PF04356.10 NM_005414.4_2 - 0.24 11.2 9.7 0.43 10.4 9.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF489) DUF4407 PF14362.4 NM_005414.4_2 - 0.96 8.6 13.0 1.5 7.9 13.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF342 PF03961.11 NM_005414.4_2 - 7.2 5.0 19.2 13 4.1 19.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Fimbrial_PilY2 PF14481.4 NM_001271014.1_3 - 0.088 12.4 0.4 0.34 10.5 0.4 2.1 1 0 0 1 1 1 0 Type 4 fimbrial biogenesis protein PilY2 Nsp1_C PF05064.11 NM_012346.4_2 - 2.1e-37 127.3 6.5 4.2e-37 126.4 6.5 1.4 1 0 0 1 1 1 1 Nsp1-like C-terminal region DUF4164 PF13747.4 NM_012346.4_2 - 0.14 12.3 5.6 0.045 13.9 1.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) GAS PF13851.4 NM_012346.4_2 - 0.43 9.8 12.9 0.86 8.8 12.9 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Prp18 PF02840.13 NM_012346.4_2 - 7.6 6.5 6.4 6.1 6.8 0.1 2.3 2 0 0 2 2 2 0 Prp18 domain SBF PF01758.14 NM_152679.3_1 - 5.6e-34 117.4 17.9 1.1e-33 116.4 17.9 1.4 1 0 0 1 1 1 1 Sodium Bile acid symporter family OAD_beta PF03977.11 NM_152679.3_1 - 0.0071 15.2 3.9 0.0071 15.2 3.9 2.2 1 1 2 3 3 3 1 Na+-transporting oxaloacetate decarboxylase beta subunit C2 PF00168.28 NM_001168408.1_1 - 3.7e-38 129.8 0.0 1.8e-18 66.6 0.1 2.5 2 0 0 2 2 2 2 C2 domain PDZ PF00595.22 NM_001168408.1_1 - 8e-10 38.8 0.0 1.5e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) CoaE PF01121.18 NM_001128631.2_2 - 3.4e-58 196.1 0.0 4.5e-58 195.7 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.4 NM_001128631.2_2 - 0.0016 18.8 0.2 0.0034 17.8 0.2 1.5 1 1 0 1 1 1 1 AAA domain Exo70 PF03081.13 NM_001145297.3_3 - 3.9e-77 259.7 3.0 3.9e-77 259.7 3.0 1.5 2 0 0 2 2 2 1 Exo70 exocyst complex subunit COG5 PF10392.7 NM_001145297.3_3 - 0.016 15.3 3.4 0.047 13.7 3.4 1.8 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Vps52 PF04129.10 NM_001145297.3_3 - 0.028 13.1 6.7 0.062 11.9 1.0 2.1 2 0 0 2 2 2 0 Vps52 / Sac2 family RolB_RolC PF02027.15 NM_001145297.3_3 - 0.16 11.5 0.2 0.34 10.4 0.2 1.5 1 0 0 1 1 1 0 RolB/RolC glucosidase family 7tm_4 PF13853.4 NM_001005497.1_1 - 1.5e-49 169.1 26.4 2e-49 168.7 26.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005497.1_1 - 2.9e-23 82.3 29.4 8.4e-23 80.8 29.3 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001005497.1_1 - 4.4e-05 22.9 30.6 6.1e-05 22.4 30.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx zf-H2C2_2 PF13465.4 NM_001278663.1_1 - 4.7e-97 314.3 135.0 4.9e-09 36.1 1.6 18.7 18 0 0 18 18 18 16 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001278663.1_1 - 4.4e-66 215.7 94.9 2.8e-05 24.2 0.5 16.7 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001278663.1_1 - 1.4e-28 97.0 95.2 0.013 16.2 0.7 15.8 15 0 0 15 15 14 14 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001278663.1_1 - 8e-21 73.7 53.3 0.062 13.5 0.2 15.1 15 0 0 15 15 14 10 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001278663.1_1 - 7.6e-17 60.7 83.1 0.02 14.7 0.3 16.3 15 1 0 15 15 15 8 C2H2-type zinc finger XPA_N PF01286.16 NM_001278663.1_1 - 9.8e-17 60.6 71.5 0.56 10.1 0.1 15.6 16 0 0 16 16 16 14 XPA protein N-terminal Zn-ribbon_8 PF09723.8 NM_001278663.1_1 - 3.2e-13 49.4 81.5 0.073 13.1 4.3 11.1 4 2 10 14 14 14 13 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001278663.1_1 - 6.3e-12 44.9 42.3 2.7 7.7 0.0 15.0 15 0 0 15 15 15 6 zinc-finger C2H2-type zf-trcl PF13451.4 NM_001278663.1_1 - 4.1e-11 42.5 67.0 0.36 10.6 0.1 13.0 11 3 1 12 12 12 7 Probable zinc-ribbon domain SprT-like PF10263.7 NM_001278663.1_1 - 8.8e-07 28.8 78.6 0.036 13.8 5.1 7.8 1 1 4 6 6 6 5 SprT-like family ADK_lid PF05191.12 NM_001278663.1_1 - 0.0057 16.5 47.2 1.4 8.9 0.5 8.8 3 2 7 10 10 10 6 Adenylate kinase, active site lid DZR PF12773.5 NM_001278663.1_1 - 0.0083 16.0 59.5 1.6e+04 -40.9 59.5 7.9 1 1 0 1 1 0 0 Double zinc ribbon BolA PF01722.16 NM_001278663.1_1 - 7 6.9 15.2 45 4.3 0.1 6.3 4 2 2 6 6 6 0 BolA-like protein Antimicrobial_2 PF08023.10 NM_001278663.1_2 - 0.0026 18.1 0.2 50 4.4 0.0 6.0 7 1 0 7 7 7 2 Frog antimicrobial peptide NID PF07292.11 NM_005533.4_2 - 1.1e-55 186.1 0.0 8.4e-28 96.7 0.1 2.3 2 0 0 2 2 2 2 Nmi/IFP 35 domain (NID) IFP_35_N PF07334.11 NM_005533.4_2 - 1.2e-11 44.4 0.2 3.5e-11 42.9 0.0 2.0 2 0 0 2 2 2 1 Interferon-induced 35 kDa protein (IFP 35) N-terminus KH_6 PF15985.3 NM_016042.3_1 - 2e-13 50.3 0.1 4.1e-13 49.3 0.1 1.6 1 0 0 1 1 1 1 KH domain LRR_8 PF13855.4 NM_001197296.1_2 - 6.8e-44 147.3 22.9 9.1e-16 57.3 1.1 5.8 4 2 1 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 NM_001197296.1_2 - 2.2e-23 81.7 28.3 8.2e-06 25.9 0.6 7.7 4 1 3 8 8 8 7 Leucine Rich repeats (2 copies) VWC PF00093.16 NM_001197296.1_2 - 4.6e-11 42.7 14.6 1.1e-10 41.5 14.6 1.7 1 0 0 1 1 1 1 von Willebrand factor type C domain LRR_5 PF13306.4 NM_001197296.1_2 - 1.3e-08 34.8 1.2 6.9e-05 22.7 0.1 2.6 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_1 PF00560.31 NM_001197296.1_2 - 1.5e-05 24.6 25.5 1.4 9.5 0.1 10.3 8 2 2 10 10 10 2 Leucine Rich Repeat FNIP PF05725.10 NM_001197296.1_2 - 2.9e-05 24.0 0.6 8.3 6.5 0.2 4.9 3 1 2 5 5 5 1 FNIP Repeat LRR_9 PF14580.4 NM_001197296.1_2 - 3.9e-05 23.1 16.1 1.3 8.4 0.6 4.7 1 1 3 5 5 5 3 Leucine-rich repeat Amnionless PF14828.4 NM_001197296.1_2 - 0.00052 18.9 4.4 0.00086 18.1 4.4 1.4 1 0 0 1 1 1 1 Amnionless LRR_6 PF13516.4 NM_001197296.1_2 - 0.02 14.8 0.2 0.11 12.5 0.2 9.0 11 0 0 11 11 10 0 Leucine Rich repeat BUD22 PF09073.8 NM_001197296.1_2 - 0.44 9.7 13.3 0.66 9.1 13.3 1.1 1 0 0 1 1 1 0 BUD22 SERTA PF06031.11 NM_001197296.1_2 - 1.5 8.4 7.6 10 5.8 0.1 2.9 3 0 0 3 3 3 0 SERTA motif Spore_coat_CotO PF14153.4 NM_001197296.1_2 - 2 8.2 12.1 2.1 8.1 10.8 1.6 2 0 0 2 2 1 0 Spore coat protein CotO SAPS PF04499.13 NM_001197296.1_2 - 7.3 5.1 9.5 0.51 8.9 4.6 1.5 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein MscS_TM PF12794.5 NM_001197296.1_2 - 8.4 5.0 6.4 18 3.9 6.4 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF1510 PF07423.9 NM_001197296.1_2 - 9.9 5.4 12.9 19 4.5 12.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) EF-hand_6 PF13405.4 NM_001286548.1_2 - 1.4e-10 40.1 1.8 0.001 18.7 0.3 4.3 5 0 0 5 5 5 3 EF-hand domain EF-hand_1 PF00036.30 NM_001286548.1_2 - 2.5e-08 32.7 3.1 0.012 14.9 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 NM_001286548.1_2 - 1.4e-07 31.7 1.4 2.3e-05 24.6 1.4 2.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 NM_001286548.1_2 - 0.0006 19.4 0.3 0.0024 17.5 0.1 2.2 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.4 NM_001286548.1_2 - 0.0011 18.2 4.5 0.55 9.7 0.2 3.4 3 0 0 3 3 3 2 EF hand DUF1126 PF06565.10 NM_001286548.1_2 - 0.0013 18.3 0.0 0.0028 17.3 0.0 1.4 1 0 0 1 1 1 1 DUF1126 PH-like domain PH PF00169.27 NM_016445.2_1 - 3.1e-34 117.5 0.4 4.5e-16 59.1 0.0 3.1 3 0 0 3 3 3 2 PH domain DEP PF00610.19 NM_016445.2_1 - 1e-15 57.4 0.0 2.2e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_11 PF15413.4 NM_016445.2_1 - 7.6e-11 42.2 5.7 0.00033 20.9 0.8 3.8 3 1 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.4 NM_016445.2_1 - 4.9e-08 33.2 0.0 0.017 15.3 0.0 2.8 2 2 0 2 2 2 2 Pleckstrin homology domain PH_3 PF14593.4 NM_016445.2_1 - 5.4e-06 26.3 0.1 1.2 9.1 0.0 3.3 3 0 0 3 3 3 3 PH domain PH_8 PF15409.4 NM_016445.2_1 - 0.002 18.2 1.5 1.9 8.7 0.9 3.4 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.4 NM_016445.2_1 - 0.017 15.3 0.2 0.57 10.3 0.0 2.8 3 0 0 3 3 3 0 Pleckstrin homology domain PH_2 PF08458.8 NM_016445.2_1 - 0.11 12.7 0.0 6.6 7.0 0.0 2.3 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_4 PF15404.4 NM_016445.2_1 - 0.12 12.1 0.3 10 5.7 0.0 3.1 4 0 0 4 4 4 0 Pleckstrin homology domain DUF4562 PF15123.4 NM_152543.2_2 - 6e-58 193.7 0.4 9.2e-58 193.1 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4562) SURF4 PF02077.13 NM_033161.3_3 - 1.7e-127 424.5 7.6 2.2e-127 424.1 7.6 1.1 1 0 0 1 1 1 1 SURF4 family DoxX PF07681.10 NM_033161.3_3 - 0.005 17.3 10.9 0.1 13.1 0.2 3.2 3 0 0 3 3 3 2 DoxX DAP3 PF10236.7 NM_033657.2_2 - 1.8e-92 309.8 0.0 2.2e-92 309.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.4 NM_033657.2_2 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 NM_033657.2_2 - 0.16 12.3 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA helicase tRNA-synt_1 PF00133.20 NM_001167733.2_3 - 6.3e-182 605.9 0.0 6.2e-181 602.6 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.11 NM_001167733.2_3 - 2.6e-31 108.5 0.0 4.2e-31 107.8 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.9 NM_001167733.2_3 - 5e-16 58.4 0.0 9.4e-08 31.1 0.0 4.1 4 0 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.4 NM_001167733.2_3 - 6.5e-05 22.4 0.0 0.0066 15.9 0.0 2.2 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.17 NM_001167733.2_3 - 0.002 17.4 0.0 0.15 11.3 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain FimP PF09766.7 NM_001167733.2_3 - 0.032 13.4 0.9 0.048 12.8 0.9 1.1 1 0 0 1 1 1 0 Fms-interacting protein tRNA-synt_1f PF01921.16 NM_001167733.2_3 - 0.055 12.2 0.0 0.5 9.1 0.0 2.3 3 0 0 3 3 3 0 tRNA synthetases class I (K) tRNA-synt_1b PF00579.23 NM_001167733.2_3 - 0.064 12.4 0.2 0.22 10.7 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) ANF_receptor PF01094.26 NM_138697.3_1 - 7.1e-72 242.3 0.0 8.6e-72 242.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 NM_138697.3_1 - 1.1e-39 136.6 14.8 1.1e-39 136.6 14.8 2.9 3 0 0 3 3 3 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 NM_138697.3_1 - 2.7e-13 49.6 9.0 2.7e-13 49.6 9.0 3.1 3 0 0 3 3 3 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 NM_138697.3_1 - 1.5e-08 34.6 0.3 3e-08 33.6 0.4 1.5 1 1 0 1 1 1 1 Periplasmic binding protein RRM_1 PF00076.20 NM_006711.4_3 - 1.3e-17 63.2 0.0 2.1e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 NM_006711.4_3 - 0.0015 18.4 0.0 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 Limkain b1 RRM_7 PF16367.3 NM_006711.4_3 - 0.0016 18.4 0.0 0.003 17.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.4 NM_006711.4_3 - 0.013 15.4 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 NM_006711.4_3 - 0.016 14.7 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 NM_006711.4_3 - 0.016 15.1 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif RRM_occluded PF16842.3 NM_006711.4_3 - 0.042 13.6 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Macoilin PF09726.7 NM_006711.4_3 - 0.043 12.3 26.6 0.075 11.4 26.6 1.3 1 0 0 1 1 1 0 Transmembrane protein LAP1C PF05609.10 NM_006711.4_3 - 1.1 8.2 18.3 1.5 7.7 18.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Pep_M12B_propep PF01562.17 NM_014244.4_1 - 2.2e-34 118.5 0.0 4.1e-34 117.7 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.12 NM_014244.4_1 - 3.1e-33 114.1 0.0 4.7e-33 113.5 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.17 NM_014244.4_1 - 6.2e-24 83.8 53.7 9.5e-10 38.4 4.8 5.3 5 0 0 5 5 5 4 Thrombospondin type 1 domain Reprolysin PF01421.17 NM_014244.4_1 - 5.2e-18 65.6 0.0 9.1e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 NM_014244.4_1 - 7.1e-14 52.3 0.1 1.4e-13 51.3 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 NM_014244.4_1 - 3.7e-10 40.3 0.1 6e-10 39.6 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_014244.4_1 - 4e-09 36.5 0.1 7.3e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_014244.4_1 - 8.1e-06 25.5 0.1 1.4e-05 24.7 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.9 NM_014244.4_1 - 0.0031 18.1 7.4 0.021 15.4 7.4 2.6 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.22 NM_014244.4_1 - 0.0095 15.7 0.2 0.016 14.9 0.2 1.3 1 0 0 1 1 1 1 Matrixin DUF4953 PF16313.3 NM_014244.4_1 - 0.21 10.6 0.3 0.33 10.0 0.3 1.1 1 0 0 1 1 1 0 Met-zincin Aa_trans PF01490.16 NM_001145017.1_3 - 1.1e-62 211.9 42.0 6e-62 209.5 42.0 1.8 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Prothymosin PF03247.12 NM_002823.4_3 - 6.4e-36 123.1 51.7 1.1e-35 122.3 51.7 1.3 1 0 0 1 1 1 1 Prothymosin/parathymosin family LSR PF05624.12 NM_002823.4_3 - 0.06 13.2 0.7 0.06 13.2 0.7 2.1 2 0 0 2 2 2 0 Lipolysis stimulated receptor (LSR) CDC45 PF02724.12 NM_002823.4_3 - 0.44 8.7 17.7 0.53 8.4 17.7 1.1 1 0 0 1 1 1 0 CDC45-like protein PhzC-PhzF PF02567.14 NM_001033083.1_3 - 1e-56 192.3 0.0 1.4e-56 191.9 0.0 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein zf-H2C2_2 PF13465.4 NM_001289185.1_3 - 7.6e-78 253.6 89.3 4.3e-09 36.3 0.6 15.2 14 2 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001289185.1_3 - 8.2e-47 155.0 99.2 1.2e-05 25.3 0.3 13.8 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001289185.1_3 - 4.3e-28 95.4 90.8 0.018 15.7 0.3 13.6 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_001289185.1_3 - 2e-22 78.5 0.9 4e-22 77.5 0.9 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001289185.1_3 - 2.6e-20 71.8 73.9 0.00046 19.9 0.5 13.6 13 0 0 13 13 13 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001289185.1_3 - 5.9e-08 32.6 47.4 0.027 14.5 3.2 8.4 5 3 5 10 10 10 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001289185.1_3 - 0.00032 20.8 59.6 0.24 11.6 0.4 11.4 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001289185.1_3 - 0.0037 17.1 45.7 6.1 6.8 0.0 10.9 12 0 0 12 12 12 5 XPA protein N-terminal FYVE PF01363.19 NM_001289185.1_3 - 0.0048 16.9 55.8 0.0072 16.3 3.2 6.1 2 2 3 5 5 5 3 FYVE zinc finger zinc_ribbon_15 PF17032.3 NM_001289185.1_3 - 0.24 12.0 46.1 0.26 11.9 1.0 7.3 4 2 4 8 8 8 0 zinc-ribbon family C1_4 PF07975.10 NM_001289185.1_3 - 3.5 7.8 52.9 1.6 8.9 2.2 8.2 2 2 6 9 9 9 0 TFIIH C1-like domain zf-H2C2_2 PF13465.4 NM_001297588.1_1 - 1.5e-99 322.2 121.4 4.2e-08 33.2 0.4 17.3 17 0 0 17 17 17 17 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001297588.1_1 - 6.9e-53 174.1 138.2 2.8e-06 27.3 2.0 16.5 16 0 0 16 16 16 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001297588.1_1 - 6.4e-30 101.1 133.1 0.0032 18.0 1.7 16.1 16 0 0 16 16 16 15 C2H2-type zinc finger KRAB PF01352.25 NM_001297588.1_1 - 5.5e-23 80.2 0.1 5.5e-23 80.2 0.1 2.0 2 0 0 2 2 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001297588.1_1 - 8.3e-11 41.4 110.3 0.18 11.7 0.3 16.0 16 0 0 16 16 16 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001297588.1_1 - 5.2e-09 36.1 97.4 0.0071 16.5 0.4 14.9 14 1 1 15 15 15 9 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001297588.1_1 - 3.6e-08 33.2 93.3 0.0079 16.2 3.1 11.3 5 2 7 12 12 12 9 Zinc ribbon domain XPA_N PF01286.16 NM_001297588.1_1 - 0.001 18.9 88.2 0.27 11.2 0.1 15.7 16 0 0 16 16 16 6 XPA protein N-terminal BolA PF01722.16 NM_001297588.1_1 - 0.0072 16.5 18.7 0.032 14.4 0.4 4.9 4 1 1 5 5 5 2 BolA-like protein ADK_lid PF05191.12 NM_001297588.1_1 - 0.18 11.7 60.7 3 7.8 2.4 11.1 10 2 1 11 11 11 0 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 NM_001297588.1_1 - 1.1 9.9 74.0 1.8 9.2 5.7 8.1 3 2 5 8 8 8 0 zinc-ribbon family zf-H2C2_2 PF13465.4 NM_001297588.1_2 - 0.0031 17.8 0.6 0.014 15.7 0.6 2.2 1 0 0 1 1 1 1 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001297588.1_2 - 0.51 10.8 4.7 23 5.5 0.2 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C3HC4_2 PF13923.4 NM_017831.3_2 - 1.3e-10 40.8 8.9 1.3e-10 40.8 8.9 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Di19 PF05605.10 NM_017831.3_2 - 2.9e-10 40.1 14.5 3.2e-10 40.0 4.8 2.7 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_UBOX PF13445.4 NM_017831.3_2 - 4.4e-09 36.1 6.3 4.4e-09 36.1 6.3 2.8 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_017831.3_2 - 4e-08 32.8 9.5 4e-08 32.8 9.5 3.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_017831.3_2 - 5e-08 32.8 8.3 5e-08 32.8 8.3 3.9 3 1 1 4 4 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 NM_017831.3_2 - 1.9e-07 31.1 10.0 1.9e-07 31.1 10.0 3.9 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.4 NM_017831.3_2 - 2.6e-06 27.1 7.0 2.6e-06 27.1 7.0 3.7 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_017831.3_2 - 1.6e-05 24.7 8.6 1.6e-05 24.7 8.6 3.4 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.4 NM_017831.3_2 - 0.00021 20.9 7.7 0.00021 20.9 7.7 3.7 3 0 0 3 3 3 2 Prokaryotic RING finger family 4 zf-Nse PF11789.6 NM_017831.3_2 - 0.0027 17.4 4.7 0.0087 15.7 4.7 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.13 NM_017831.3_2 - 0.0029 17.6 0.1 0.043 13.9 0.0 2.3 2 0 0 2 2 2 1 U-box domain zf-RING_6 PF14835.4 NM_017831.3_2 - 0.098 12.4 4.3 0.27 11.0 4.3 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.3 NM_017831.3_2 - 2.4 7.8 7.2 2.1 8.0 5.2 2.1 2 0 0 2 2 1 0 RING-like zinc finger Rad50_zn_hook PF04423.12 NM_017831.3_2 - 7.3 6.4 10.5 6.5 6.5 1.6 2.8 3 0 0 3 3 2 0 Rad50 zinc hook motif zf-RING_10 PF16685.3 NM_017831.3_2 - 7.8 6.6 18.7 0.0081 16.1 6.5 2.3 2 0 0 2 2 1 0 zinc RING finger of MSL2 RRM_1 PF00076.20 NM_001003792.2_2 - 3.7e-30 103.4 0.0 1.8e-15 56.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC4_WD40 PF12894.5 NM_001190241.1_3 - 2e-08 34.3 1.0 0.47 10.7 0.0 5.0 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 NM_001190241.1_3 - 2.1e-07 31.4 16.4 0.61 10.9 0.0 7.6 9 0 0 9 9 9 3 WD domain, G-beta repeat DUF1725 PF08333.9 NM_001190241.1_3 - 0.05 13.2 0.9 0.13 11.9 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) DUF4597 PF15366.4 NM_206967.2_3 - 1.2e-37 127.3 4.5 1.8e-37 126.7 4.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4597) CD20 PF04103.13 NM_198264.1_1 - 2.5e-07 30.8 1.1 2.5e-07 30.8 1.1 2.2 1 1 1 2 2 2 1 CD20-like family PTR2 PF00854.19 NM_001145998.1_1 - 4.7e-128 427.2 8.0 6.6e-116 387.3 1.6 2.2 2 0 0 2 2 2 2 POT family DUF4397 PF14344.4 NM_001145998.1_1 - 0.083 13.5 0.4 0.22 12.2 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4397) DUF2207 PF09972.7 NM_001145998.1_1 - 4.9 5.7 7.2 5 5.7 1.9 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) zf-H2C2_2 PF13465.4 NM_032828.3_2 - 1.2e-69 227.7 97.0 2.2e-07 30.9 1.0 15.0 16 0 0 16 16 16 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_032828.3_2 - 1.9e-53 175.9 119.8 1.4e-05 25.1 0.5 15.8 16 0 0 16 16 16 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_032828.3_2 - 1.9e-31 105.8 106.6 0.0073 16.9 2.8 15.2 14 0 0 14 14 14 13 C2H2-type zinc finger KRAB PF01352.25 NM_032828.3_2 - 6.1e-22 76.9 0.2 1.1e-21 76.1 0.2 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_032828.3_2 - 3.7e-15 55.3 82.9 0.0043 16.8 1.9 12.8 12 0 0 12 12 12 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_032828.3_2 - 0.00035 20.5 69.7 0.32 11.0 2.4 9.0 3 2 6 10 10 10 5 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_032828.3_2 - 0.008 16.8 48.3 0.081 13.6 3.6 7.7 2 1 4 6 6 6 1 zinc-ribbon family DZR PF12773.5 NM_032828.3_2 - 0.12 12.3 53.1 3.7 7.5 1.7 7.4 3 1 1 4 4 4 0 Double zinc ribbon zf-H2C2_2 PF13465.4 NM_032828.3_3 - 1.5e-08 34.6 16.6 0.00044 20.5 0.0 4.0 3 0 0 3 3 3 2 Zinc-finger double domain Hyphal_reg_CWP PF11765.6 NM_032828.3_3 - 3.1e-05 22.9 0.4 4.8e-05 22.3 0.4 1.2 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal zf-H2C2_2 PF13465.4 NM_001324152.1_1 - 8.9e-113 364.0 129.5 5.7e-09 35.9 0.3 20.0 20 0 0 20 20 19 18 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001324152.1_1 - 7.4e-96 309.5 119.3 2.7e-06 27.4 0.3 18.4 17 0 0 17 17 17 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001324152.1_1 - 9.4e-46 150.4 111.8 0.0065 17.1 0.3 18.4 17 0 0 17 17 17 17 C2H2-type zinc finger KRAB PF01352.25 NM_001324152.1_1 - 8.3e-23 79.7 0.3 8.3e-23 79.7 0.3 1.9 2 0 0 2 2 2 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001324152.1_1 - 2.7e-19 68.9 75.2 0.00059 19.8 1.5 10.8 8 3 2 11 11 11 8 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001324152.1_1 - 2.1e-14 52.9 95.9 0.0012 18.6 0.6 17.2 17 0 0 17 17 17 8 C2H2-type zinc finger ADK_lid PF05191.12 NM_001324152.1_1 - 2.7e-07 30.4 39.7 0.0026 17.6 0.3 8.8 7 2 0 7 7 7 5 Adenylate kinase, active site lid DZR PF12773.5 NM_001324152.1_1 - 0.00018 21.4 70.8 1.6e+04 -4.6 17.8 9.0 1 1 1 2 2 0 0 Double zinc ribbon DUF3268 PF11672.6 NM_001324152.1_1 - 0.00029 21.0 57.8 0.2 11.9 0.9 8.9 3 1 8 13 13 13 8 zinc-finger-containing domain C1_4 PF07975.10 NM_001324152.1_1 - 0.0044 17.1 79.2 0.4 10.8 1.2 11.9 6 3 5 12 12 12 7 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 NM_001324152.1_1 - 0.008 16.8 74.4 0.55 10.9 1.5 9.8 2 1 5 9 9 9 4 zinc-ribbon family zf-trcl PF13451.4 NM_001324152.1_1 - 0.057 13.2 72.9 2.6 7.9 0.2 14.8 14 3 0 14 14 14 0 Probable zinc-ribbon domain XPA_N PF01286.16 NM_001324152.1_1 - 1.5 8.8 66.6 6.9 6.7 0.0 15.6 17 0 0 17 17 17 0 XPA protein N-terminal BolA PF01722.16 NM_001324152.1_1 - 3.9 7.7 25.2 5.5 7.2 0.4 6.5 5 1 0 5 5 5 0 BolA-like protein T4_deiodinase PF00837.15 NM_000792.6_1 - 4.9e-101 336.8 0.0 6.3e-101 336.5 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase Kazal_1 PF00050.19 NM_001271718.1_3 - 2.9e-18 65.5 3.9 4.5e-18 64.9 3.9 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 NM_001271718.1_3 - 2.2e-09 37.2 1.6 3.5e-09 36.6 1.6 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain RasGEF PF00617.17 NM_001164387.1_3 - 4.9e-51 173.2 0.4 8.2e-51 172.5 0.4 1.4 1 0 0 1 1 1 1 RasGEF domain PDZ PF00595.22 NM_001164387.1_3 - 4.7e-14 52.4 0.1 1e-13 51.3 0.1 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RasGEF_N PF00618.18 NM_001164387.1_3 - 4.2e-12 46.1 0.4 1e-10 41.7 0.4 2.7 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 NM_001164387.1_3 - 1.6e-11 44.6 0.0 3.3e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain cNMP_binding PF00027.27 NM_001164387.1_3 - 5.2e-11 42.3 0.0 3.7e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_2 PF13180.4 NM_001164387.1_3 - 0.0029 17.7 0.0 0.0076 16.4 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Ig_3 PF13927.4 NM_001256064.1_3 - 4.7e-72 238.5 0.0 1.3e-12 48.0 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 NM_001256064.1_3 - 8e-61 202.0 0.0 4.9e-13 48.8 0.0 7.0 6 1 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001256064.1_3 - 4.4e-49 164.6 0.1 6.9e-09 35.8 0.0 6.3 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 NM_001256064.1_3 - 2.7e-45 152.3 0.0 7.9e-10 38.6 0.0 7.3 6 1 0 6 6 6 6 Immunoglobulin domain V-set PF07686.15 NM_001256064.1_3 - 8.8e-25 86.9 6.3 0.006 16.6 0.0 9.9 6 4 3 9 9 9 6 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_001256064.1_3 - 5.7e-11 42.5 0.1 0.058 13.7 0.0 6.8 7 0 0 7 7 7 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 NM_001256064.1_3 - 3.3e-08 33.6 0.1 0.46 10.7 0.0 5.4 6 0 0 6 6 5 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 NM_001256064.1_3 - 9.9e-07 28.6 0.0 2.8 7.9 0.0 5.4 6 0 0 6 6 5 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 NM_001256064.1_3 - 0.00048 20.0 0.1 0.95 9.4 0.0 2.9 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.13 NM_001256064.1_3 - 0.0058 16.3 6.0 26 4.5 0.0 6.1 6 1 0 6 6 6 0 Adenovirus E3 region protein CR1 Sp38 PF07354.10 NM_001256064.1_3 - 0.0063 15.3 0.2 1.9 7.2 0.0 3.2 4 0 0 4 4 4 1 Zona-pellucida-binding protein (Sp38) TatD_DNase PF01026.19 NM_001146171.1_2 - 7.3e-53 179.4 0.0 9e-53 179.1 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Parathyroid PF01279.15 NM_000315.3_2 - 5.6e-07 30.0 0.1 8.5e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 Parathyroid hormone family PA28_beta PF02252.16 NM_005789.3_2 - 2.8e-64 215.0 3.4 3.8e-64 214.6 3.4 1.2 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.16 NM_005789.3_2 - 6.7e-24 83.7 2.0 1.2e-23 82.8 2.0 1.5 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit EGF PF00008.25 NM_017617.4_1 - 1.1e-197 639.3 597.7 1.5e-08 34.6 9.6 38.1 38 0 0 38 38 36 35 EGF-like domain hEGF PF12661.5 NM_017617.4_1 - 2.6e-114 370.3 504.7 1.3e-06 28.7 7.6 39.4 39 0 0 39 39 36 33 Human growth factor-like EGF EGF_CA PF07645.13 NM_017617.4_1 - 1.6e-43 146.5 587.8 9e-11 41.7 6.0 37.4 22 10 16 38 38 31 21 Calcium-binding EGF domain Ank_2 PF12796.5 NM_017617.4_1 - 7.5e-30 103.2 20.4 2.1e-11 44.1 1.4 4.2 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) Ank PF00023.28 NM_017617.4_1 - 1.1e-25 88.8 6.2 0.0002 21.5 0.0 7.0 6 0 0 6 6 6 6 Ankyrin repeat Notch PF00066.15 NM_017617.4_1 - 1.2e-25 89.5 57.2 2.2e-12 47.1 13.8 15.2 17 2 1 18 18 4 3 LNR domain NOD PF06816.11 NM_017617.4_1 - 2.9e-25 87.5 0.0 4.6e-25 86.8 0.0 1.3 1 0 0 1 1 1 1 NOTCH protein DUF3454 PF11936.6 NM_017617.4_1 - 3.6e-25 88.0 22.6 1.5e-24 86.1 22.6 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3454) EGF_2 PF07974.11 NM_017617.4_1 - 4.8e-24 84.3 676.8 0.0015 18.7 6.6 39.3 39 1 0 39 39 35 27 EGF-like domain NODP PF07684.10 NM_017617.4_1 - 7.1e-23 80.4 0.1 7.1e-23 80.4 0.1 3.5 3 0 0 3 3 2 1 NOTCH protein Ank_5 PF13857.4 NM_017617.4_1 - 1.3e-20 73.1 11.1 2.9e-08 33.7 0.1 5.8 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_017617.4_1 - 9.6e-18 64.2 2.4 4.5e-06 27.0 0.0 4.8 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_017617.4_1 - 1e-16 59.2 2.8 0.0038 17.5 0.0 7.2 7 0 0 7 7 6 3 Ankyrin repeat EGF_3 PF12947.5 NM_017617.4_1 - 0.0016 18.5 4.1 0.0016 18.5 4.1 38.5 31 5 7 38 38 33 8 EGF domain TFIIA PF03153.11 NM_017617.4_1 - 9.4 6.0 8.3 16 5.2 8.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_LBD PF02931.21 NM_001146040.1_3 - 1.6e-53 181.2 0.0 2.1e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_001146040.1_3 - 3e-40 138.7 0.7 1.4e-33 116.9 0.1 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region BTB PF00651.29 NM_001007229.1_1 - 8.7e-33 112.7 1.3 2e-32 111.6 0.3 1.9 1 1 1 2 2 2 1 BTB/POZ domain MATH PF00917.24 NM_001007229.1_1 - 4.2e-06 26.7 0.0 1.2e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 MATH domain BACK PF07707.13 NM_001007229.1_1 - 0.018 15.0 0.2 0.38 10.7 0.0 2.7 3 0 0 3 3 3 0 BTB And C-terminal Kelch Prefoldin PF02996.15 NM_003796.3_1 - 8.8e-15 54.6 0.0 1.8e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.4 NM_003796.3_1 - 1e-08 35.0 0.0 2.2e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Prefoldin subunit DUF3835 PF12927.5 NM_003796.3_1 - 0.15 12.9 0.9 0.86 10.4 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3835) YTH PF04146.13 NM_017798.3_1 - 2.9e-40 136.6 0.0 4.4e-40 136.0 0.0 1.3 1 0 0 1 1 1 1 YT521-B-like domain Cys_knot PF00007.20 NM_000737.3_3 - 8.2e-34 115.9 7.8 1.1e-33 115.6 7.8 1.1 1 0 0 1 1 1 1 Cystine-knot domain Glyco_transf_8 PF01501.18 NM_001184702.1_1 - 1.3e-18 67.3 2.0 1.2e-16 60.9 2.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.6 NM_001184702.1_1 - 0.021 14.0 0.1 0.054 12.7 0.0 1.5 1 1 1 2 2 2 0 Mannosyltransferase putative PMP22_Claudin PF00822.18 NM_001307.5_3 - 1.1e-54 184.6 11.6 1.5e-54 184.2 11.6 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001307.5_3 - 1.1e-09 38.3 10.5 4.9e-09 36.1 10.5 1.8 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PH PF00169.27 NM_001195608.1_3 - 6.3e-30 103.6 0.4 1.1e-17 64.3 0.1 2.4 2 0 0 2 2 2 2 PH domain PH_8 PF15409.4 NM_001195608.1_3 - 2.6e-09 37.1 0.3 0.00061 19.9 0.0 2.5 2 0 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.4 NM_001195608.1_3 - 8.3e-07 29.3 1.1 0.00022 21.5 0.6 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain Mcp5_PH PF12814.5 NM_001195608.1_3 - 6.9e-06 26.0 0.0 0.0024 17.8 0.0 2.3 2 0 0 2 2 2 2 Meiotic cell cortex C-terminal pleckstrin homology PH_9 PF15410.4 NM_001195608.1_3 - 1.3e-05 25.4 0.2 0.24 11.6 0.0 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain PCI PF01399.25 NM_001320655.1_2 - 1.7e-17 63.7 1.8 3.2e-17 62.8 1.8 1.5 1 0 0 1 1 1 1 PCI domain Ig_3 PF13927.4 NM_198590.2_3 - 1.9e-12 47.4 0.4 4.3e-09 36.7 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_198590.2_3 - 1.5e-07 31.6 0.0 0.0012 19.0 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_198590.2_3 - 1.5e-07 31.2 0.1 7.3e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.15 NM_198590.2_3 - 7.4e-06 26.0 0.2 0.0044 17.0 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 NM_198590.2_3 - 6.2e-05 23.0 0.7 0.023 14.7 0.2 2.9 2 1 0 2 2 2 2 Immunoglobulin domain Ig_5 PF16681.3 NM_198590.2_3 - 0.085 13.2 0.1 7.3 7.0 0.0 2.5 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain AAA PF00004.27 NM_001013690.4_2 - 2e-17 63.7 0.0 2.8e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 NM_001013690.4_2 - 0.015 15.1 0.0 0.031 14.1 0.0 1.5 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Sugar_tr PF00083.22 NM_001184732.1_2 - 1.7e-34 119.4 11.6 2.1e-34 119.0 11.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 NM_001184732.1_2 - 5.8e-29 101.0 23.3 8.8e-29 100.4 23.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Trypsin PF00089.24 NM_002257.3_1 - 9.8e-69 231.4 0.1 1.2e-68 231.2 0.1 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_002257.3_1 - 7.9e-07 29.9 0.0 1.4e-06 29.2 0.0 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_002257.3_1 - 0.00089 19.5 0.1 0.0025 18.1 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) DUF4704 PF15787.3 NM_001004339.2_2 - 0.0039 16.3 1.5 0.0039 16.3 1.5 2.1 3 1 0 3 3 3 1 Domain of unknown function (DUF4704) LRR_4 PF12799.5 NM_001004339.2_2 - 0.0065 16.7 11.4 0.016 15.5 0.4 4.2 2 1 2 4 4 4 2 Leucine Rich repeats (2 copies) Peptidase_C54 PF03416.17 NM_001321287.1_1 - 2.7e-99 331.7 0.0 3.4e-99 331.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 ICAP-1_inte_bdg PF10480.7 NM_001319069.1_2 - 1.3e-96 322.2 0.0 1.8e-96 321.8 0.0 1.1 1 0 0 1 1 1 1 Beta-1 integrin binding protein PID PF00640.21 NM_001319069.1_2 - 0.0026 17.7 0.0 0.0046 16.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PP2C PF00481.19 NM_177951.2_1 - 2.7e-89 299.1 0.0 3.3e-89 298.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.11 NM_177951.2_1 - 9.8e-12 45.0 0.0 1.9e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain PI-PLC-X PF00388.17 NM_001144382.1_1 - 4.1e-60 201.5 0.1 7.4e-60 200.6 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 NM_001144382.1_1 - 6.4e-39 132.7 0.3 2e-38 131.2 0.3 1.9 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_12 PF16457.3 NM_001144382.1_1 - 1.5e-21 77.2 0.6 3.3e-21 76.1 0.1 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain EF-hand_like PF09279.9 NM_001144382.1_1 - 1.6e-16 60.4 0.0 3e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.28 NM_001144382.1_1 - 5.9e-16 58.5 0.0 1.3e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain PH PF00169.27 NM_001144382.1_1 - 3.9e-06 27.2 0.1 1.1e-05 25.8 0.1 1.8 1 0 0 1 1 1 1 PH domain Mcp5_PH PF12814.5 NM_001144382.1_1 - 0.0034 17.4 0.0 0.0075 16.2 0.0 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology EF-hand_7 PF13499.4 NM_001144382.1_1 - 0.067 13.5 0.0 0.23 11.8 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_2 PF09068.9 NM_183360.2_3 - 8.9e-35 119.4 1.6 8.9e-35 119.4 1.6 1.7 2 0 0 2 2 1 1 EF hand EF-hand_3 PF09069.9 NM_183360.2_3 - 3.5e-30 104.1 1.1 5e-30 103.6 0.1 1.8 2 0 0 2 2 1 1 EF-hand ZZ PF00569.15 NM_183360.2_3 - 2.8e-09 36.5 10.5 6e-09 35.5 10.5 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.14 NM_183360.2_3 - 0.0036 17.5 10.7 0.0075 16.4 10.7 1.6 1 0 0 1 1 1 1 C1 domain Macoilin PF09726.7 NM_183360.2_3 - 0.035 12.6 3.5 0.044 12.2 3.5 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF342 PF03961.11 NM_183360.2_3 - 0.046 12.2 5.5 0.07 11.6 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Seryl_tRNA_N PF02403.20 NM_183360.2_3 - 0.097 12.8 10.2 0.23 11.6 10.2 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain CRISPR_Cse2 PF09485.8 NM_183360.2_3 - 0.32 11.4 8.4 0.55 10.6 7.9 1.6 1 1 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) DUF4407 PF14362.4 NM_183360.2_3 - 0.44 9.7 4.6 0.68 9.1 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mnd1 PF03962.13 NM_183360.2_3 - 0.45 10.2 14.9 0.89 9.3 14.9 1.4 1 0 0 1 1 1 0 Mnd1 family APG6 PF04111.10 NM_183360.2_3 - 1.5 8.0 9.7 2.8 7.1 9.7 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 MerR-DNA-bind PF09278.9 NM_183360.2_3 - 2.2 8.7 11.7 2.7 8.4 9.9 2.2 1 1 0 1 1 1 0 MerR, DNA binding IncA PF04156.12 NM_183360.2_3 - 4.5 6.9 13.5 11 5.7 13.5 1.6 1 0 0 1 1 1 0 IncA protein GET2 PF08690.8 NM_183360.2_3 - 10 5.6 8.9 3.6 7.0 0.3 2.5 2 0 0 2 2 2 0 GET complex subunit GET2 Aminotran_1_2 PF00155.19 NM_005309.2_2 - 1.5e-32 113.1 0.0 1.7e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Gal-bind_lectin PF00337.20 NM_001040078.2_2 - 1.3e-74 247.9 0.5 2.1e-36 124.3 0.0 2.2 2 0 0 2 2 2 2 Galactoside-binding lectin ARD PF03079.12 NM_001306077.1_1 - 3e-47 160.6 0.1 4.3e-47 160.1 0.1 1.2 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.9 NM_001306077.1_1 - 4.4e-07 29.4 0.0 8.2e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.17 NM_001306077.1_1 - 0.00034 20.4 0.1 0.0006 19.6 0.1 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain PI3K_1B_p101 PF10486.7 NM_001251853.1_1 - 1.1e-257 857.1 0.0 1.4e-257 856.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF2284 PF10050.7 NM_001251853.1_1 - 0.026 14.1 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) PI3K_1B_p101 PF10486.7 NM_001251853.1_2 - 1e-110 370.9 0.5 1.3e-110 370.5 0.5 1.1 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit XK-related PF09815.7 NM_001011718.1_1 - 3.4e-120 400.8 19.9 4e-120 400.6 19.9 1.1 1 0 0 1 1 1 1 XK-related protein Glyco_hydro_35 PF01301.17 NM_001317040.1_2 - 4.2e-123 410.9 0.0 5.4e-123 410.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.13 NM_001317040.1_2 - 9.5e-13 48.1 0.1 1.5e-10 40.9 0.1 2.2 1 1 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.4 NM_001317040.1_2 - 1.1e-09 38.8 0.8 4.9e-08 33.4 0.0 3.2 3 1 0 3 3 3 1 Beta-galactosidase jelly roll domain G-gamma PF00631.20 NM_001198756.1_1 - 4.1e-17 61.8 0.0 6.5e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 GGL domain AMP-binding PF00501.26 NM_001323892.1_1 - 4.2e-50 170.4 0.0 6e-50 169.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.23 NM_001323892.1_1 - 2.3e-06 27.7 0.1 4.5e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.4 NM_001323892.1_1 - 0.00018 22.3 0.0 0.00057 20.7 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PQQ PF01011.19 NM_001323892.1_1 - 0.011 15.5 0.0 0.08 12.8 0.0 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat PQQ_2 PF13360.4 NM_001323892.1_1 - 0.023 14.2 0.0 0.1 12.0 0.0 1.9 2 0 0 2 2 2 0 PQQ-like domain PQQ_3 PF13570.4 NM_001323892.1_2 - 2.9e-17 62.5 0.0 0.00065 20.0 0.0 5.4 5 0 0 5 5 5 5 PQQ-like domain PQQ_2 PF13360.4 NM_001323892.1_2 - 4.1e-08 33.0 0.0 0.0019 17.7 0.0 2.7 1 1 0 2 2 2 2 PQQ-like domain PQQ PF01011.19 NM_001323892.1_2 - 4.7e-08 32.4 0.0 0.53 10.2 0.0 5.2 5 0 0 5 5 5 3 PQQ enzyme repeat SPRY PF00622.26 NM_033290.3_2 - 3.6e-17 62.5 0.0 5.9e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_033290.3_2 - 1.3e-12 46.9 0.2 1.5e-11 43.6 0.0 2.4 2 0 0 2 2 2 1 SPRY-associated domain zf-B_box PF00643.22 NM_033290.3_2 - 3.3e-09 36.6 23.7 1.2e-08 34.9 0.8 4.0 3 0 0 3 3 3 2 B-box zinc finger fn3 PF00041.19 NM_033290.3_2 - 8e-08 32.4 0.2 1.5e-07 31.5 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_UBOX PF13445.4 NM_033290.3_2 - 3.8e-07 29.9 9.0 3.8e-07 29.9 9.0 3.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_033290.3_2 - 3e-06 26.9 8.4 3e-06 26.9 8.4 3.5 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_033290.3_2 - 1.2e-05 24.9 11.7 1.2e-05 24.9 11.7 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_033290.3_2 - 1.5e-05 24.9 12.0 1.5e-05 24.9 12.0 4.4 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 NM_033290.3_2 - 0.0001 22.4 11.4 0.0001 22.4 11.4 3.8 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_033290.3_2 - 0.00055 19.6 11.1 0.00055 19.6 11.1 4.3 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Pur_ac_phosph_N PF16656.3 NM_033290.3_2 - 0.035 14.6 0.2 0.071 13.6 0.2 1.5 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Serine_rich PF08824.8 NM_033290.3_2 - 1.2 9.0 4.3 3.1 7.6 4.3 1.6 1 1 0 1 1 1 0 Serine rich protein interaction domain NDK PF00334.17 NM_198175.1_2 - 1.5e-54 183.5 0.0 2e-54 183.2 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase ARA70 PF12489.6 NM_001145263.1_3 - 3.2e-73 244.1 30.3 1.5e-46 157.7 4.7 5.9 3 1 2 5 5 5 4 Nuclear coactivator RhoGAP PF00620.25 NM_001166277.1_3 - 3e-42 143.9 0.5 1.7e-41 141.4 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.27 NM_001166277.1_3 - 1.7e-15 57.2 2.2 1.4e-14 54.3 0.1 2.9 3 0 0 3 3 2 1 PH domain PH_11 PF15413.4 NM_001166277.1_3 - 0.00026 21.2 1.0 0.00069 19.9 1.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain ADIP PF11559.6 NM_001166277.1_3 - 0.0015 18.5 8.6 0.003 17.5 8.6 1.5 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding PH_8 PF15409.4 NM_001166277.1_3 - 0.0026 17.9 0.0 0.0026 17.9 0.0 1.9 2 0 0 2 2 1 1 Pleckstrin homology domain Cnn_1N PF07989.9 NM_001166277.1_3 - 0.012 15.6 12.1 0.012 15.6 12.1 3.2 3 1 1 4 4 2 0 Centrosomin N-terminal motif 1 AAA_13 PF13166.4 NM_001166277.1_3 - 0.063 11.8 10.7 0.088 11.3 10.7 1.1 1 0 0 1 1 1 0 AAA domain ATG16 PF08614.9 NM_001166277.1_3 - 0.081 13.0 20.2 0.54 10.3 20.2 2.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.6 NM_001166277.1_3 - 0.12 11.5 8.7 0.19 10.9 8.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Nsp1_C PF05064.11 NM_001166277.1_3 - 0.18 11.5 11.9 0.052 13.2 8.4 1.9 2 0 0 2 2 2 0 Nsp1-like C-terminal region Herpes_UL6 PF01763.14 NM_001166277.1_3 - 0.28 9.5 4.7 0.41 9.0 4.7 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like DMPK_coil PF08826.8 NM_001166277.1_3 - 0.38 10.8 20.4 3.1 7.8 9.3 2.7 2 0 0 2 2 2 0 DMPK coiled coil domain like ApoO PF09769.7 NM_001166277.1_3 - 0.55 10.1 2.8 0.33 10.8 0.6 1.7 2 0 0 2 2 2 0 Apolipoprotein O APG6 PF04111.10 NM_001166277.1_3 - 0.83 8.8 16.9 1.3 8.2 16.9 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 KfrA_N PF11740.6 NM_001166277.1_3 - 1.1 9.8 11.7 0.72 10.4 2.6 3.1 2 1 1 3 3 2 0 Plasmid replication region DNA-binding N-term Tup_N PF08581.8 NM_001166277.1_3 - 4 7.7 14.8 0.028 14.6 2.8 2.8 3 0 0 3 3 3 0 Tup N-terminal IncA PF04156.12 NM_001166277.1_3 - 6.7 6.3 20.9 7.5 6.2 18.0 2.3 2 1 0 2 2 2 0 IncA protein RGS PF00615.17 NM_033345.3_1 - 2.3e-36 124.5 2.3 3.4e-36 123.9 2.3 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain Lipocalin PF00061.21 NM_001319042.1_2 - 9e-21 74.5 1.0 1.2e-20 74.1 1.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Pep_deformylase PF01327.19 NM_001319042.1_2 - 0.022 14.2 0.0 0.03 13.8 0.0 1.1 1 0 0 1 1 1 0 Polypeptide deformylase Lipocalin_7 PF14651.4 NM_001319042.1_2 - 0.063 13.1 0.3 0.13 12.1 0.2 1.4 1 1 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family SMC_N PF02463.17 NM_005445.3_1 - 1.5e-62 210.8 29.5 3.2e-62 209.7 29.5 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 NM_005445.3_1 - 5.7e-21 74.9 0.0 1.5e-20 73.5 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.4 NM_005445.3_1 - 8.2e-13 48.6 19.3 8.2e-13 48.6 19.3 4.9 2 2 1 4 4 4 1 AAA ATPase domain AAA_21 PF13304.4 NM_005445.3_1 - 6.6e-10 39.1 21.5 3.6e-06 26.9 0.0 5.4 4 2 1 6 6 6 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 NM_005445.3_1 - 5.6e-09 36.7 46.7 5.6e-09 36.7 46.7 8.0 2 2 1 4 4 4 1 AAA domain AAA_29 PF13555.4 NM_005445.3_1 - 0.0029 17.1 0.0 0.0063 16.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.10 NM_005445.3_1 - 0.29 10.3 24.7 3.1 7.0 0.2 4.4 3 1 0 4 4 4 0 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.10 NM_005445.3_1 - 5.6 6.9 39.2 0.18 11.7 0.3 6.6 4 2 2 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pkinase PF00069.23 NM_001256685.1_2 - 8.2e-73 244.9 0.0 1.2e-72 244.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001256685.1_2 - 4.5e-40 137.4 0.0 7.1e-40 136.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 NM_001256685.1_2 - 2.1e-14 52.9 0.2 4.9e-14 51.7 0.2 1.7 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.4 NM_001256685.1_2 - 1.4e-08 34.3 0.0 2e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001256685.1_2 - 9.1e-06 25.0 0.1 2.1e-05 23.8 0.1 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001256685.1_2 - 0.0017 18.2 0.0 0.072 12.9 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.18 NM_001256685.1_2 - 0.053 13.0 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase zf-H2C2_2 PF13465.4 NM_001099282.1_2 - 1.1e-59 196.2 74.6 3.6e-08 33.3 0.5 10.5 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001099282.1_2 - 1.4e-50 166.8 70.1 6e-06 26.3 1.1 10.2 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001099282.1_2 - 1.3e-26 90.9 64.5 0.0046 17.5 0.4 10.4 10 0 0 10 10 10 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001099282.1_2 - 3.6e-08 33.2 51.1 0.0046 16.9 2.8 7.5 5 4 5 10 10 10 6 Zinc ribbon domain C1_4 PF07975.10 NM_001099282.1_2 - 1.2e-07 31.8 34.7 0.48 10.6 0.7 8.4 1 1 6 8 8 8 6 TFIIH C1-like domain zf-C2H2_6 PF13912.4 NM_001099282.1_2 - 3.5e-07 29.9 42.8 1.5 8.7 0.2 9.6 9 0 0 9 9 9 6 C2H2-type zinc finger XPA_N PF01286.16 NM_001099282.1_2 - 1e-06 28.6 42.5 2.6 8.0 0.4 9.8 10 0 0 10 10 10 4 XPA protein N-terminal CpXC PF14353.4 NM_001099282.1_2 - 6.1e-06 26.1 27.4 2.4 8.1 0.1 9.2 4 2 5 10 10 10 2 CpXC protein zf-C2HC_2 PF13913.4 NM_001099282.1_2 - 3.6e-05 23.4 23.6 1.3 8.9 0.0 7.9 7 0 0 7 7 7 3 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 NM_001099282.1_2 - 0.0022 18.1 24.5 7.2 6.9 0.0 8.3 9 0 0 9 9 8 2 Zinc-finger double-stranded RNA-binding Pectate_lyase22 PF14583.4 NM_001099282.1_2 - 0.021 13.4 0.0 0.051 12.1 0.0 1.5 2 0 0 2 2 2 0 Oligogalacturonate lyase zinc_ribbon_15 PF17032.3 NM_001099282.1_2 - 0.078 13.6 43.3 0.56 10.9 1.4 6.2 2 2 3 6 6 6 0 zinc-ribbon family DUF3268 PF11672.6 NM_001099282.1_2 - 0.13 12.5 30.2 1.2 9.4 1.2 5.2 1 1 8 9 9 9 0 zinc-finger-containing domain HypA PF01155.17 NM_001099282.1_2 - 0.14 12.0 33.3 4.5 7.2 0.3 5.7 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-trcl PF13451.4 NM_001099282.1_2 - 6 6.7 29.7 13 5.6 0.1 8.6 9 0 0 9 9 9 0 Probable zinc-ribbon domain KRAB PF01352.25 NM_001099282.1_3 - 7.2e-09 35.0 0.1 5.3e-08 32.3 0.1 2.4 1 1 0 1 1 1 1 KRAB box Dynein_IC2 PF11540.6 NM_001320884.1_2 - 1.9e-15 56.4 0.6 4e-15 55.3 0.6 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 NM_001320884.1_2 - 0.019 15.7 17.9 0.35 11.7 0.6 7.1 8 0 0 8 8 8 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001320884.1_2 - 0.022 14.9 0.0 0.12 12.6 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain 2-oxoacid_dh PF00198.21 NM_001135024.1_3 - 5.6e-73 245.1 0.0 7e-73 244.8 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 NM_001135024.1_3 - 2.3e-19 68.8 0.5 4.8e-19 67.8 0.5 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.15 NM_001135024.1_3 - 9.1e-07 29.0 0.0 2.2e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.4 NM_001135024.1_3 - 0.0063 16.2 0.0 0.078 12.7 0.0 2.2 1 1 1 2 2 2 1 Biotin-lipoyl like PUF PF00806.17 NM_015317.2_3 - 1.9e-71 231.8 9.5 2.1e-09 36.4 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.9 NM_015317.2_3 - 0.095 12.9 1.3 9.3 6.5 0.1 3.5 1 1 2 3 3 3 0 CPL (NUC119) domain PC4 PF02229.14 NM_015317.2_3 - 0.13 11.8 0.3 0.31 10.6 0.3 1.6 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) SPAN-X PF07458.10 NM_145662.3_1 - 5.5e-42 142.0 1.2 7.4e-42 141.6 1.2 1.2 1 0 0 1 1 1 1 Sperm protein associated with nucleus, mapped to X chromosome Arf PF00025.19 NM_001662.3_1 - 1.5e-75 252.4 0.1 1.8e-75 252.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 NM_001662.3_1 - 8.7e-14 51.7 0.1 1.2e-13 51.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 NM_001662.3_1 - 1.8e-13 50.2 0.0 2.3e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 NM_001662.3_1 - 5.3e-12 45.5 0.0 6.5e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 NM_001662.3_1 - 1.1e-11 44.4 1.2 2.6e-08 33.3 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 NM_001662.3_1 - 1.7e-10 40.6 0.0 2e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 NM_001662.3_1 - 0.00019 21.3 0.0 0.00029 20.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 NM_001662.3_1 - 0.027 13.6 0.1 0.044 12.9 0.1 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Aa_trans PF01490.16 NM_006841.5_2 - 5.1e-111 371.2 34.0 6e-111 370.9 34.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF3262 PF11660.6 NM_006841.5_2 - 0.053 13.7 0.2 0.053 13.7 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3262) DUF2448 PF10476.7 NM_001130924.2_1 - 3.4e-91 304.6 0.3 4.8e-91 304.1 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2448) Ima1_N PF09779.7 NM_001130924.2_1 - 3.8e-34 118.3 9.6 7e-34 117.5 9.6 1.5 1 0 0 1 1 1 1 Ima1 N-terminal domain zf-RRPl_C4 PF17026.3 NM_001130924.2_1 - 0.0019 18.1 4.1 0.0043 17.0 4.1 1.6 1 0 0 1 1 1 1 Putative ribonucleoprotein zinc-finger pf C4 type Thioredoxin PF00085.18 NM_006810.3_1 - 2.8e-73 242.3 5.1 2.8e-24 84.9 0.1 4.1 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_2 PF13098.4 NM_006810.3_1 - 1.9e-24 86.1 8.8 4.3e-07 30.2 0.0 4.4 4 0 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_7 PF13899.4 NM_006810.3_1 - 7.7e-19 67.5 1.3 1.2e-05 25.2 0.0 3.5 3 0 0 3 3 3 3 Thioredoxin-like AhpC-TSA PF00578.19 NM_006810.3_1 - 5.9e-16 58.4 2.0 0.00011 22.0 0.1 3.7 4 0 0 4 4 4 3 AhpC/TSA family OST3_OST6 PF04756.11 NM_006810.3_1 - 3.7e-15 55.9 0.8 5.1e-07 29.2 0.0 3.1 2 1 1 3 3 3 3 OST3 / OST6 family, transporter family Redoxin PF08534.8 NM_006810.3_1 - 2.6e-14 53.0 0.8 0.0018 17.8 0.0 3.3 3 0 0 3 3 3 3 Redoxin Thioredoxin_8 PF13905.4 NM_006810.3_1 - 2.9e-14 53.0 1.5 0.00024 21.3 0.1 4.8 4 2 2 6 6 6 3 Thioredoxin-like Thioredoxin_6 PF13848.4 NM_006810.3_1 - 1.2e-09 38.3 0.9 0.0017 18.2 0.0 3.8 4 0 0 4 4 4 3 Thioredoxin-like domain TraF PF13728.4 NM_006810.3_1 - 1.5e-08 34.7 0.1 0.19 11.4 0.0 3.6 3 1 0 3 3 3 3 F plasmid transfer operon protein Thioredoxin_9 PF14595.4 NM_006810.3_1 - 1e-07 31.6 0.2 0.42 10.3 0.1 3.5 3 0 0 3 3 3 3 Thioredoxin Glutaredoxin PF00462.22 NM_006810.3_1 - 2.3e-05 24.4 2.4 1.7 8.8 0.5 3.9 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin_3 PF13192.4 NM_006810.3_1 - 2.8e-05 24.0 0.2 0.058 13.3 0.0 3.3 3 0 0 3 3 3 1 Thioredoxin domain DUF2847 PF11009.6 NM_006810.3_1 - 0.00062 19.5 0.0 0.85 9.4 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2847) HyaE PF07449.9 NM_006810.3_1 - 0.0008 19.2 0.0 1.9 8.4 0.0 3.0 2 1 0 2 2 2 2 Hydrogenase-1 expression protein HyaE Thioredoxin_4 PF13462.4 NM_006810.3_1 - 1.3 9.0 8.1 10 6.1 1.3 3.3 3 1 0 3 3 3 0 Thioredoxin Ion_trans PF00520.29 NM_021096.3_1 - 2.7e-252 832.3 88.5 1e-79 267.1 12.0 4.4 5 0 0 5 5 5 4 Ion transport protein PKD_channel PF08016.10 NM_021096.3_1 - 1.4e-14 53.5 84.0 3e-08 32.6 3.4 9.6 6 3 3 9 9 9 7 Polycystin cation channel Ig_2 PF13895.4 NM_001004310.2_1 - 4e-28 97.5 0.0 1.2e-08 35.0 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 NM_001004310.2_1 - 3.6e-24 85.0 0.0 5.6e-09 36.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_001004310.2_1 - 1.1e-15 57.4 0.0 2.6e-05 24.2 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_001004310.2_1 - 4.6e-09 36.1 0.0 0.058 13.3 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_4 PF16680.3 NM_001004310.2_1 - 4.5e-06 26.8 0.1 0.004 17.3 0.0 3.4 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain V-set PF07686.15 NM_001004310.2_1 - 0.00027 20.9 0.4 0.23 11.5 0.0 4.2 3 2 1 4 4 4 1 Immunoglobulin V-set domain Receptor_2B4 PF11465.6 NM_001004310.2_1 - 0.0037 17.3 0.0 0.26 11.4 0.0 2.6 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_5 PF16681.3 NM_001004310.2_1 - 0.034 14.4 0.0 4.7 7.6 0.0 3.2 3 0 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DEAD PF00270.27 NM_001297756.1_2 - 1.1e-14 54.4 0.1 1.9e-14 53.7 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001297756.1_3 - 4.3e-10 39.8 0.0 4.6e-09 36.5 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.4 NM_001297756.1_3 - 0.0023 18.4 0.0 0.0057 17.1 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF4332 PF14229.4 NM_001297756.1_3 - 0.009 16.1 0.2 0.02 15.0 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) DNA_pol_lambd_f PF10391.7 NM_001297756.1_3 - 0.037 13.8 0.0 0.11 12.2 0.0 1.9 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda EIN3 PF04873.11 NM_173589.3_2 - 0.072 12.3 0.1 0.17 11.1 0.1 1.5 1 0 0 1 1 1 0 Ethylene insensitive 3 Bcr-Abl_Oligo PF09036.8 NM_173589.3_2 - 0.11 12.4 0.2 0.28 11.1 0.2 1.6 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain FOP_dimer PF09398.8 NM_001304502.1_2 - 8.1e-08 32.3 0.1 7.4e-06 26.0 0.0 2.4 2 0 0 2 2 2 1 FOP N terminal dimerisation domain LisH_2 PF16045.3 NM_001304502.1_2 - 0.0019 17.1 0.1 0.005 15.7 0.1 1.8 1 0 0 1 1 1 1 LisH LisH PF08513.9 NM_001304502.1_2 - 0.022 14.6 0.7 2.1 8.3 0.4 2.7 2 0 0 2 2 2 0 LisH Tetraspannin PF00335.18 NM_000560.3_2 - 4.6e-49 167.0 19.6 5.7e-49 166.6 19.6 1.1 1 0 0 1 1 1 1 Tetraspanin family wnt PF00110.17 NM_001300938.1_3 - 1.3e-92 310.5 22.5 1.8e-92 310.0 22.5 1.1 1 0 0 1 1 1 1 wnt family Memo PF01875.15 NM_001301852.1_1 - 9.6e-17 60.9 0.0 1.2e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein Memo PF01875.15 NM_001301852.1_3 - 2.6e-32 111.9 0.0 3.4e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein ORC6 PF05460.11 NM_014321.3_1 - 1.7e-17 63.6 6.4 1.1e-14 54.3 0.5 3.0 2 1 1 3 3 3 3 Origin recognition complex subunit 6 (ORC6) 7tm_1 PF00001.19 NM_016602.2_2 - 3.9e-42 144.2 0.0 1.2e-41 142.6 0.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FA_desaturase PF00487.22 NM_016602.2_2 - 3.6 7.2 9.8 0.76 9.4 0.4 2.8 1 1 2 4 4 4 0 Fatty acid desaturase DUF1211 PF06736.9 NM_001297424.1_2 - 2.9e-38 130.0 0.5 6.7e-23 80.8 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF1211) DUF1129 PF06570.9 NM_001297424.1_2 - 3.5 6.9 7.2 0.52 9.7 0.1 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF1129) Nop53 PF07767.9 NM_015710.4_1 - 1.5e-100 337.2 20.6 1.8e-100 337.0 20.6 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Glyco_transf_22 PF03901.15 NM_004855.4_2 - 8.9e-124 413.7 40.4 1.1e-123 413.4 40.4 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PMT_2 PF13231.4 NM_004855.4_2 - 0.0028 17.8 8.7 0.0028 17.8 8.7 2.2 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Pkinase_Tyr PF07714.15 NM_001297654.1_3 - 5.1e-84 281.5 0.0 6.4e-84 281.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001297654.1_3 - 8.5e-38 130.1 0.0 1.1e-36 126.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 NM_001297654.1_3 - 4.2e-20 72.0 0.0 6.6e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Lamprin PF06403.9 NM_001297654.1_3 - 0.035 13.9 0.5 0.076 12.8 0.5 1.5 1 0 0 1 1 1 0 Lamprin Kinase-like PF14531.4 NM_001297654.1_3 - 0.079 12.1 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like PRY PF13765.4 NM_006510.4_3 - 4e-22 77.5 0.3 2e-21 75.2 0.3 2.1 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 NM_006510.4_3 - 5.1e-21 74.9 0.1 9.4e-21 74.0 0.1 1.4 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 NM_006510.4_3 - 1.7e-11 44.0 0.5 1.7e-11 44.0 0.5 3.5 4 0 0 4 4 3 1 B-box zinc finger zf-C3HC4_4 PF15227.4 NM_006510.4_3 - 5.1e-10 39.2 15.0 5.1e-10 39.2 15.0 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 NM_006510.4_3 - 2e-08 33.8 13.9 8.3e-08 31.8 13.9 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_006510.4_3 - 1.1e-06 28.4 12.5 1.1e-06 28.4 7.6 3.3 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_006510.4_3 - 2.3e-05 24.0 12.4 2.3e-05 24.0 12.4 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_006510.4_3 - 0.00025 21.1 14.4 0.00025 21.1 14.4 3.2 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_006510.4_3 - 0.00026 20.6 14.9 0.00026 20.6 14.9 3.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_006510.4_3 - 0.012 15.5 13.9 0.012 15.5 13.9 3.3 2 1 1 3 3 3 0 zinc-RING finger domain Baculo_IE-1 PF05290.9 NM_006510.4_3 - 0.32 10.8 10.0 0.063 13.1 5.6 2.1 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.4 NM_006510.4_3 - 1.3 8.7 18.2 0.025 14.2 7.5 3.2 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.3 NM_006510.4_3 - 6.7 6.8 14.7 0.72 9.9 8.5 2.5 2 0 0 2 2 2 0 zinc RING finger of MSL2 Ammonium_transp PF00909.19 NM_138617.3_3 - 6e-24 84.3 24.2 8.4e-14 50.9 8.1 2.1 1 1 1 2 2 2 2 Ammonium Transporter Family Connexin PF00029.17 NM_022365.3_1 - 3.4 7.2 11.3 5.3 6.6 11.3 1.2 1 0 0 1 1 1 0 Connexin Presenilin PF01080.15 NM_022365.3_2 - 0.54 8.8 1.9 0.63 8.6 1.9 1.1 1 0 0 1 1 1 0 Presenilin EOS1 PF12326.6 NM_022365.3_2 - 0.62 9.8 1.9 0.76 9.5 1.9 1.2 1 0 0 1 1 1 0 N-glycosylation protein DnaJ PF00226.29 NM_022365.3_3 - 1.9e-22 79.0 1.4 5.4e-22 77.6 1.4 1.9 1 0 0 1 1 1 1 DnaJ domain Myb_DNA-binding PF00249.29 NM_022365.3_3 - 9.6e-13 47.9 0.5 2.1e-07 30.9 0.1 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 NM_022365.3_3 - 2.2e-05 24.5 0.5 0.031 14.4 0.6 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain DUF4234 PF14018.4 NM_022365.3_3 - 0.073 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) LRR_9 PF14580.4 NM_006305.3_1 - 2.6e-17 62.7 2.0 5e-17 61.8 1.7 1.5 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 NM_006305.3_1 - 8.7e-11 41.7 14.1 7.8e-09 35.5 1.4 3.3 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_006305.3_1 - 6.3e-07 28.9 6.9 4.9e-06 26.1 3.3 2.8 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.4 NM_006305.3_1 - 8.3e-05 22.2 8.8 0.012 15.5 0.6 3.7 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.31 NM_006305.3_1 - 1.3 9.6 10.8 3.5 8.3 0.2 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat Mpp10 PF04006.10 NM_006305.3_1 - 8.9 4.5 28.2 12 4.0 28.2 1.1 1 0 0 1 1 1 0 Mpp10 protein UQ_con PF00179.24 NM_001257397.1_1 - 6.7e-17 61.3 0.0 1e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RRM_1 PF00076.20 NM_032311.4_1 - 9.1e-10 38.1 0.0 1.6e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sprouty PF05210.11 NM_001318536.1_3 - 2.6e-35 121.0 35.2 6.7e-35 119.6 35.2 1.7 1 0 0 1 1 1 1 Sprouty protein (Spry) V-set PF07686.15 NM_138961.2_3 - 1.9e-15 56.9 2.1 3.1e-08 33.6 0.0 3.2 2 1 1 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_138961.2_3 - 1.8e-12 47.6 0.0 3e-07 30.8 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_138961.2_3 - 2.8e-09 36.8 0.0 0.00016 21.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_138961.2_3 - 8.2e-09 35.6 0.3 4.3e-06 26.8 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_138961.2_3 - 1.1e-06 28.5 0.2 0.0041 17.1 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin domain Receptor_2B4 PF11465.6 NM_138961.2_3 - 0.084 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 Galactosyl_T PF01762.19 NM_033309.2_1 - 9.6e-36 123.3 0.0 2.9e-35 121.7 0.0 1.7 1 1 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 NM_033309.2_1 - 6.4e-05 22.4 0.0 0.00024 20.5 0.0 1.7 2 0 0 2 2 2 1 Fringe-like K_channel_TID PF07941.9 NM_001165993.1_1 - 0.34 11.2 3.6 0.57 10.5 3.6 1.2 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain GDPD PF03009.15 NM_001165993.1_3 - 5.2e-25 88.5 0.0 7.4e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ripply PF14998.4 NM_001317768.1_2 - 3.7e-30 104.3 0.0 8.2e-30 103.2 0.0 1.6 1 0 0 1 1 1 1 Transcription Regulator cEGF PF12662.5 NM_001317768.1_3 - 5.3 6.9 6.3 7.6 6.4 0.1 2.6 2 0 0 2 2 2 0 Complement Clr-like EGF-like EF-hand_7 PF13499.4 NM_001168325.1_3 - 2.1e-09 37.6 8.2 2.4e-05 24.6 2.2 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_001168325.1_3 - 2.9e-07 29.4 2.2 3e-05 23.1 0.1 3.2 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 NM_001168325.1_3 - 0.00014 21.4 1.2 0.0004 20.0 0.0 2.3 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.4 NM_001168325.1_3 - 0.00083 18.7 0.0 0.0026 17.1 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 NM_001168325.1_3 - 0.0009 18.8 1.5 0.0073 15.9 0.6 2.5 2 1 0 2 2 2 1 EF-hand domain pair TRIQK PF15168.4 NM_001171799.1_1 - 1.5e-37 127.2 1.0 2.8e-37 126.3 1.0 1.5 1 0 0 1 1 1 1 Triple QxxK/R motif-containing protein family zf-C3HC4_4 PF15227.4 NM_001105522.1_1 - 6.6e-10 38.9 8.8 6.6e-10 38.9 8.8 4.0 4 1 1 5 5 5 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 NM_001105522.1_1 - 7.4e-08 32.4 0.1 1.5e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 NM_001105522.1_1 - 1.4e-07 31.1 4.5 1.4e-07 31.1 4.5 3.3 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001105522.1_1 - 2.3e-07 30.4 2.4 2.3e-07 30.4 2.4 3.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001105522.1_1 - 3.8e-07 29.9 9.1 3.8e-07 29.9 9.1 3.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-B_box PF00643.22 NM_001105522.1_1 - 3.2e-05 23.9 6.4 3.2e-05 23.9 6.4 3.2 3 1 0 3 3 3 1 B-box zinc finger zf-RING_2 PF13639.4 NM_001105522.1_1 - 0.00069 19.7 18.7 0.0012 19.0 8.6 3.3 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.4 NM_001105522.1_1 - 0.0023 17.6 6.2 0.0023 17.6 6.2 3.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.6 NM_001105522.1_1 - 0.056 13.1 5.3 0.032 13.9 2.0 2.3 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.3 NM_001105522.1_1 - 1.8 8.6 14.5 0.067 13.2 3.6 3.2 3 0 0 3 3 3 0 zinc RING finger of MSL2 CAMP_factor PF07373.9 NM_001316976.1_1 - 0.008 15.7 0.9 0.012 15.1 0.9 1.1 1 0 0 1 1 1 1 CAMP factor (Cfa) Serine_rich PF08824.8 NM_001316976.1_1 - 0.033 14.1 1.7 0.052 13.4 1.7 1.3 1 0 0 1 1 1 0 Serine rich protein interaction domain IncA PF04156.12 NM_001316976.1_1 - 0.1 12.2 6.4 0.18 11.5 6.4 1.2 1 0 0 1 1 1 0 IncA protein DUF2408 PF10303.7 NM_001316976.1_1 - 0.1 13.0 2.9 0.18 12.3 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Swi5 PF07061.9 NM_001316976.1_1 - 0.39 10.7 2.0 0.69 9.9 2.0 1.3 1 0 0 1 1 1 0 Swi5 FlxA PF14282.4 NM_001316976.1_1 - 2.8 7.9 9.0 2.4 8.0 7.7 1.5 1 1 0 1 1 1 0 FlxA-like protein Filament PF00038.19 NM_000226.3_1 - 5.8e-104 347.9 35.9 6.9e-104 347.6 35.9 1.0 1 0 0 1 1 1 1 Intermediate filament protein FlxA PF14282.4 NM_000226.3_1 - 0.0045 16.8 14.7 0.0045 16.8 14.7 4.2 3 2 2 5 5 5 1 FlxA-like protein TPR_MLP1_2 PF07926.10 NM_000226.3_1 - 0.005 16.8 32.8 0.023 14.6 15.4 3.4 2 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein DUF4407 PF14362.4 NM_000226.3_1 - 0.011 14.9 24.8 1 8.6 0.5 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) SPATA1_C PF15743.3 NM_000226.3_1 - 0.019 14.9 0.2 0.019 14.9 0.2 3.7 1 1 2 3 3 2 0 Spermatogenesis-associated C-terminus Myosin_tail_1 PF01576.17 NM_000226.3_1 - 0.093 10.4 30.1 0.51 7.9 29.1 2.0 1 1 0 1 1 1 0 Myosin tail IncA PF04156.12 NM_000226.3_1 - 0.1 12.3 38.0 1.5 8.4 23.6 3.6 2 1 1 3 3 3 0 IncA protein FliJ PF02050.14 NM_000226.3_1 - 0.13 12.4 29.9 10 6.2 5.8 4.2 3 1 1 4 4 4 0 Flagellar FliJ protein DUF5082 PF16888.3 NM_000226.3_1 - 0.2 11.9 29.9 0.47 10.7 0.8 4.4 2 1 2 4 4 4 0 Domain of unknown function (DUF5082) TBPIP PF07106.11 NM_000226.3_1 - 0.34 10.5 34.1 0.5 10.0 0.6 3.6 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Spc7 PF08317.9 NM_000226.3_1 - 1.2 7.8 37.0 0.17 10.6 19.9 2.9 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.10 NM_000226.3_1 - 1.2 9.0 24.7 0.56 10.1 5.1 4.1 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 NM_000226.3_1 - 1.2 9.1 24.9 0.021 14.7 8.3 3.6 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.10 NM_000226.3_1 - 1.3 8.2 10.7 2.7 7.2 3.2 2.9 1 1 3 4 4 4 0 Reovirus sigma C capsid protein Prefoldin_2 PF01920.18 NM_000226.3_1 - 1.5 8.7 33.1 0.24 11.2 2.7 5.0 5 1 1 6 6 4 0 Prefoldin subunit CENP-F_leu_zip PF10473.7 NM_000226.3_1 - 2.3 8.1 41.3 5.1 7.0 4.9 4.5 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4776 PF16003.3 NM_000226.3_1 - 2.5 6.9 8.4 3.3 6.5 8.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) RasGAP_C PF03836.13 NM_000226.3_1 - 3.1 7.8 31.5 0.5 10.4 6.1 3.9 2 1 1 4 4 4 0 RasGAP C-terminus FAM184 PF15665.3 NM_000226.3_1 - 3.5 7.2 28.8 0.31 10.6 17.6 3.0 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B APG6 PF04111.10 NM_000226.3_1 - 4.9 6.3 33.1 0.95 8.7 15.3 2.9 2 1 0 2 2 2 0 Autophagy protein Apg6 Apolipoprotein PF01442.16 NM_000226.3_1 - 5 6.9 30.6 59 3.4 0.3 3.5 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Mod_r PF07200.11 NM_000226.3_1 - 5 7.1 38.7 0.41 10.6 0.8 4.0 1 1 3 4 4 4 0 Modifier of rudimentary (Mod(r)) protein Jnk-SapK_ap_N PF09744.7 NM_000226.3_1 - 5.2 7.1 36.2 0.55 10.3 3.6 3.9 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 Golgin_A5 PF09787.7 NM_000226.3_1 - 9.3 5.5 33.1 4 6.7 4.9 2.5 1 1 1 2 2 2 0 Golgin subfamily A member 5 IP_trans PF02121.16 NM_012399.4_2 - 1.9e-117 391.0 1.5 3e-117 390.4 1.5 1.3 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein SNF2_N PF00176.21 NM_001128847.1_1 - 2.1e-73 247.0 0.8 2.1e-73 247.0 0.8 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.29 NM_001128847.1_1 - 6.2e-22 77.9 0.3 6.5e-20 71.4 0.0 3.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.11 NM_001128847.1_1 - 6.1e-21 74.4 15.6 6.1e-21 74.4 15.6 4.4 5 0 0 5 5 5 1 HSA Bromodomain PF00439.23 NM_001128847.1_1 - 2.5e-20 72.2 0.2 1.4e-19 69.8 0.3 2.3 2 0 0 2 2 2 1 Bromodomain SnAC PF14619.4 NM_001128847.1_1 - 9e-18 64.6 7.4 9e-18 64.6 7.4 6.5 7 2 1 8 8 8 1 Snf2-ATP coupling, chromatin remodelling complex BRK PF07533.14 NM_001128847.1_1 - 1.3e-17 63.0 0.0 2.6e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 BRK domain QLQ PF08880.9 NM_001128847.1_1 - 5.8e-15 54.6 4.3 1.3e-14 53.5 4.3 1.7 1 0 0 1 1 1 1 QLQ ResIII PF04851.13 NM_001128847.1_1 - 1.1e-09 38.4 0.0 1.1e-09 38.4 0.0 3.3 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DUF2009 PF09418.8 NM_001128847.1_1 - 0.3 10.0 12.6 0.29 10.0 10.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2009) zf-C2H2 PF00096.24 NM_001197051.1_1 - 1.1e-12 47.5 33.2 0.0027 17.9 0.8 5.8 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001197051.1_1 - 2.1e-09 37.2 24.3 0.0017 18.6 0.2 4.8 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001197051.1_1 - 5.6e-06 26.6 33.0 0.21 12.4 0.6 6.1 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001197051.1_1 - 0.013 15.7 6.0 0.24 11.7 0.5 3.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.3 NM_001197051.1_1 - 0.35 11.1 10.4 0.064 13.4 5.1 2.3 1 1 2 3 3 3 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.8 NM_001197051.1_1 - 0.72 9.9 11.0 0.81 9.7 0.1 3.0 3 0 0 3 3 3 0 Zinc ribbon domain zf-H2C2_5 PF13909.4 NM_001197051.1_1 - 9.5 5.9 7.0 1.3 8.7 1.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain CAP_N PF01213.17 NM_001197051.1_2 - 2.4 7.4 4.6 7 5.9 4.1 1.8 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal TMPIT PF07851.11 NM_001080825.2_1 - 2.1e-155 516.7 16.7 2.6e-155 516.4 16.7 1.1 1 0 0 1 1 1 1 TMPIT-like protein Helo_like_N PF17111.3 NM_001080825.2_1 - 0.44 9.7 3.5 0.91 8.7 3.5 1.4 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Peptidase_C1 PF00112.21 NM_022164.2_1 - 7.7e-52 176.4 0.0 1e-51 176.0 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Pacifastin_I PF05375.11 NM_022164.2_1 - 0.00054 19.5 5.4 0.0016 18.0 5.4 1.8 1 0 0 1 1 1 1 Pacifastin inhibitor (LCMII) Propeptide_C1 PF08127.11 NM_022164.2_1 - 0.019 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C1 propeptide FKS1_dom1 PF14288.4 NM_001301685.1_3 - 0.1 12.9 1.8 0.35 11.1 1.5 2.2 1 1 1 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 TetR_C_3 PF08362.9 NM_001123396.1_2 - 0.088 12.6 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 YcdC-like protein, C-terminal region 7tm_1 PF00001.19 NM_001123396.1_3 - 1.5e-48 165.2 19.4 2.3e-48 164.6 19.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001123396.1_3 - 1.2e-05 24.7 21.4 1.6e-05 24.3 21.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001123396.1_3 - 0.0029 16.9 12.3 0.0029 16.9 12.3 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx ACBP PF00887.17 NM_001079863.1_3 - 1.1e-31 108.8 0.8 1.6e-31 108.2 0.8 1.2 1 0 0 1 1 1 1 Acyl CoA binding protein NACHT PF05729.10 NM_001079821.2_1 - 1.3e-48 164.9 0.1 3.7e-48 163.4 0.0 1.9 2 0 0 2 2 2 1 NACHT domain PYRIN PF02758.14 NM_001079821.2_1 - 2.7e-21 75.4 0.0 9.6e-21 73.6 0.0 2.1 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain LRR_6 PF13516.4 NM_001079821.2_1 - 3.6e-19 67.0 26.7 0.00015 21.4 0.1 7.5 7 0 0 7 7 7 5 Leucine Rich repeat FISNA PF14484.4 NM_001079821.2_1 - 4.4e-15 55.5 0.2 8e-15 54.7 0.2 1.5 1 0 0 1 1 1 1 Fish-specific NACHT associated domain LRR_4 PF12799.5 NM_001079821.2_1 - 5.9e-06 26.4 26.6 0.076 13.3 0.9 6.5 2 1 5 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_001079821.2_1 - 0.066 12.9 19.0 0.48 10.1 0.9 5.5 5 1 0 5 5 5 0 Leucine rich repeat LRR_1 PF00560.31 NM_001079821.2_1 - 0.73 10.4 29.8 19 6.1 0.0 8.8 8 0 0 8 8 8 0 Leucine Rich Repeat AbLIM_anchor PF16182.3 NM_001323399.1_2 - 1.9e-77 261.5 10.3 6.2e-57 194.0 6.4 2.1 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 NM_001323399.1_2 - 1e-14 54.1 0.8 2e-14 53.2 0.8 1.5 1 0 0 1 1 1 1 Villin headpiece domain STAT1_TAZ2bind PF12162.6 NM_001323399.1_2 - 0.044 13.2 0.8 6 6.4 0.0 2.6 2 0 0 2 2 2 0 STAT1 TAZ2 binding domain RAG1 PF12940.5 NM_000448.2_2 - 0 1269.6 0.6 0 1268.8 0.6 1.3 1 0 0 1 1 1 1 Recombination-activation protein 1 (RAG1), recombinase RAG1_imp_bd PF12560.6 NM_000448.2_2 - 3.8e-122 407.2 13.2 6.6e-122 406.4 13.2 1.4 1 0 0 1 1 1 1 RAG1 importin binding zf-RAG1 PF10426.7 NM_000448.2_2 - 3.1e-18 65.5 11.7 2.4e-17 62.6 4.9 2.5 2 0 0 2 2 2 2 Recombination-activating protein 1 zinc-finger domain zf-C3HC4 PF00097.23 NM_000448.2_2 - 3.1e-06 26.8 13.8 3.1e-06 26.8 13.8 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_000448.2_2 - 3.9e-06 26.5 13.0 3.9e-06 26.5 13.0 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 NM_000448.2_2 - 0.0013 18.5 8.2 0.0013 18.5 8.2 2.1 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.4 NM_000448.2_2 - 0.002 18.2 13.3 0.002 18.2 13.3 4.0 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.4 NM_000448.2_2 - 0.0031 17.4 9.9 0.019 14.8 9.9 2.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 NM_000448.2_2 - 0.0042 17.1 13.3 0.0042 17.1 13.3 3.3 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.3 NM_000448.2_2 - 0.1 12.6 18.8 0.015 15.2 11.0 3.0 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-Nse PF11789.6 NM_000448.2_2 - 3.7 7.3 10.5 12 5.6 10.5 1.9 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.4 NM_000448.2_2 - 5.3 7.0 20.4 0.2 11.5 12.5 3.0 2 0 0 2 2 2 0 zinc-RING finger domain AT_hook PF02178.17 NM_001300919.1_2 - 0.015 15.0 37.4 0.036 13.8 2.3 4.2 4 0 0 4 4 4 0 AT hook motif zf-AN1 PF01428.14 NM_001270999.1_3 - 2.6e-21 75.3 25.8 1.4e-10 41.0 7.0 2.8 2 0 0 2 2 2 2 AN1-like Zinc finger UIM PF02809.18 NM_001270999.1_3 - 0.0006 19.4 5.7 0.0006 19.4 5.7 2.6 2 0 0 2 2 2 1 Ubiquitin interaction motif Transp_Tc5_C PF04236.13 NM_001270999.1_3 - 0.0025 18.0 16.7 0.055 13.7 3.3 2.4 2 0 0 2 2 2 2 Tc5 transposase C-terminal domain zf-C5HC2 PF02928.14 NM_001270999.1_3 - 7.2 6.9 14.9 2 8.7 2.6 2.7 2 0 0 2 2 2 0 C5HC2 zinc finger Apolipo_F PF15148.4 NM_001638.2_1 - 1.7e-89 298.5 0.0 2.2e-89 298.1 0.0 1.1 1 0 0 1 1 1 1 Apolipoprotein F V-SNARE_C PF12352.6 NM_004287.4_2 - 4.6e-12 45.9 1.8 1e-11 44.8 1.8 1.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.11 NM_004287.4_2 - 0.00041 20.1 0.2 0.0008 19.1 0.2 1.5 1 0 0 1 1 1 1 Sec20 EzrA PF06160.10 NM_004287.4_2 - 0.12 10.4 2.8 0.17 9.9 2.8 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA V-SNARE PF05008.13 NM_004287.4_2 - 0.17 12.1 1.7 0.28 11.4 1.7 1.3 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus IncA PF04156.12 NM_004287.4_2 - 5.2 6.7 7.5 8.5 6.0 7.5 1.2 1 0 0 1 1 1 0 IncA protein RICTOR_N PF14664.4 NM_001285439.1_2 - 1e-108 363.6 1.3 1.6e-108 363.0 1.3 1.3 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho PF14665.4 NM_001285439.1_2 - 8.1e-49 164.4 5.1 8.1e-49 164.4 5.1 2.0 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, phosphorylation-site RasGEF_N_2 PF14663.4 NM_001285439.1_2 - 5.8e-36 123.0 3.0 1.6e-35 121.6 0.2 2.8 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.4 NM_001285439.1_2 - 7.8e-33 112.2 3.8 8.2e-32 108.9 0.8 3.5 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.4 NM_001285439.1_2 - 1.4e-31 108.4 1.9 1.4e-29 101.9 0.3 3.9 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 7tm_1 PF00001.19 NM_001838.3_1 - 2.8e-48 164.4 28.5 6e-48 163.3 28.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001838.3_1 - 0.00022 20.6 26.3 0.00032 20.0 26.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Ctr PF04145.13 NM_001838.3_1 - 0.29 11.6 2.4 46 4.5 2.6 2.9 2 1 0 2 2 2 0 Ctr copper transporter family DUF621 PF04789.13 NM_001838.3_1 - 0.43 9.6 22.7 0.67 8.9 22.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF621) E1-E2_ATPase PF00122.18 NM_152296.4_3 - 2.7e-58 196.7 2.9 5.3e-58 195.8 2.9 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 NM_152296.4_3 - 2.1e-44 151.3 1.9 2.8e-44 150.9 0.2 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 NM_152296.4_3 - 1.5e-24 85.8 0.0 3.4e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 NM_152296.4_3 - 6.7e-19 68.9 0.2 1.3e-15 58.2 0.2 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 NM_152296.4_3 - 1.3e-18 66.3 0.0 2.6e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 NM_152296.4_3 - 8.3e-06 25.6 0.9 0.00091 18.9 0.5 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase SNCAIP_SNCA_bd PF16700.3 NM_001308100.1_1 - 4.4e-24 83.8 7.3 9.9e-24 82.7 7.3 1.6 1 0 0 1 1 1 1 Synphilin-1 alpha-Synuclein-binding domain Ank_2 PF12796.5 NM_001308100.1_1 - 3.6e-16 59.4 1.1 5.9e-07 29.8 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_001308100.1_1 - 7.6e-13 48.3 0.6 0.0025 18.0 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_001308100.1_1 - 1.7e-12 47.5 0.5 0.00046 20.6 0.0 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 NM_001308100.1_1 - 1.7e-06 28.1 2.4 0.015 15.6 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 NM_001308100.1_1 - 0.00021 21.3 0.5 1.6 9.4 0.1 4.3 4 0 0 4 4 4 2 Ankyrin repeat Oxysterol_BP PF01237.16 NM_148908.3_1 - 7e-81 271.8 8.3 6e-79 265.4 8.3 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 NM_148908.3_1 - 5.3e-14 52.5 0.1 1.4e-13 51.1 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 NM_148908.3_1 - 1.7e-08 34.4 0.3 3.4e-08 33.5 0.3 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 NM_148908.3_1 - 2.1e-05 24.8 6.6 3.2e-05 24.2 3.3 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.4 NM_148908.3_1 - 0.00074 19.6 0.0 0.0016 18.6 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Snapin_Pallidin PF14712.4 NM_148908.3_1 - 0.38 11.1 4.9 0.059 13.7 1.1 1.6 2 0 0 2 2 2 0 Snapin/Pallidin COX6C PF02937.13 NM_004374.3_3 - 3.2e-35 119.9 1.2 5e-35 119.3 1.2 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc Na_Ca_ex PF01699.22 NM_001193288.2_1 - 2.5e-58 196.2 55.1 1.1e-30 106.4 20.6 3.2 3 0 0 3 3 3 2 Sodium/calcium exchanger protein BRCA-2_helical PF09169.8 NM_000059.3_3 - 1.5e-96 321.3 0.2 8.2e-95 315.7 0.0 2.9 2 0 0 2 2 2 1 BRCA2, helical BRCA2 PF00634.16 NM_000059.3_3 - 1.4e-89 293.0 35.7 4.9e-13 48.2 0.2 8.7 8 0 0 8 8 8 8 BRCA2 repeat BRCA-2_OB3 PF09104.8 NM_000059.3_3 - 1.6e-53 180.0 0.1 1.7e-52 176.6 0.0 2.7 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 BRCA-2_OB1 PF09103.8 NM_000059.3_3 - 1.1e-41 141.5 0.0 4.4e-41 139.5 0.0 2.2 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Tower PF09121.8 NM_000059.3_3 - 2.9e-20 72.0 5.6 9.1e-20 70.4 5.6 2.0 1 0 0 1 1 1 1 Tower Methyltransf_15 PF09445.8 NM_024831.7_1 - 8.4e-45 152.3 0.0 1.8e-44 151.3 0.0 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.4 NM_024831.7_1 - 2.6e-06 27.9 0.0 5.6e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_024831.7_1 - 5.1e-06 26.2 0.0 1.1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.14 NM_024831.7_1 - 1.1e-05 25.2 0.0 2.1e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.16 NM_024831.7_1 - 2.1e-05 24.2 0.0 4.9e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.13 NM_024831.7_1 - 0.0022 17.5 0.0 0.014 15.0 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.10 NM_024831.7_1 - 0.0022 18.4 0.0 0.0045 17.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.11 NM_024831.7_1 - 0.072 12.3 1.3 0.087 12.1 0.1 1.7 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) DinI PF06183.11 NM_024831.7_1 - 0.13 12.5 0.5 0.31 11.3 0.5 1.6 1 0 0 1 1 1 0 DinI-like family HEAT PF02985.20 NM_002265.5_3 - 7.8e-17 59.8 8.0 7.2e-06 25.7 0.0 8.6 10 0 0 10 10 10 3 HEAT repeat HEAT_EZ PF13513.4 NM_002265.5_3 - 1.1e-15 57.6 3.5 5e-11 42.7 0.0 6.0 7 1 1 8 8 8 1 HEAT-like repeat IBN_N PF03810.17 NM_002265.5_3 - 9.7e-12 44.5 0.8 4.6e-11 42.3 0.1 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Arm PF00514.21 NM_002265.5_3 - 8.3e-09 35.1 1.6 0.00084 19.2 0.0 4.4 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 NM_002265.5_3 - 2.8e-08 33.9 0.1 0.00019 21.6 0.0 4.6 2 2 2 4 4 4 1 HEAT repeats Cnd1 PF12717.5 NM_002265.5_3 - 4.4e-06 26.6 0.6 0.0042 17.0 0.0 3.3 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.6 NM_002265.5_3 - 0.00012 21.6 2.4 0.74 9.2 0.0 4.0 3 1 1 4 4 4 2 CLASP N terminal YjgP_YjgQ PF03739.12 NM_002265.5_3 - 0.055 12.2 0.1 0.1 11.3 0.1 1.3 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family V-ATPase_H_C PF11698.6 NM_002265.5_3 - 0.38 10.8 4.4 1 9.3 0.3 2.9 2 0 0 2 2 2 0 V-ATPase subunit H DUF3699 PF12480.6 NM_130899.2_2 - 1.6e-30 104.9 0.6 2.8e-30 104.1 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3699) Macoilin PF09726.7 NM_130899.2_2 - 1.7 7.0 21.0 2.3 6.6 21.0 1.3 1 0 0 1 1 1 0 Transmembrane protein TPR_2 PF07719.15 NM_004623.4_1 - 1.8e-08 33.7 5.4 0.077 13.0 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 NM_004623.4_1 - 5.6e-08 32.2 7.3 0.026 14.2 0.4 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_004623.4_1 - 0.021 14.9 1.4 2.6 8.3 0.3 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.4 NM_004623.4_1 - 0.028 15.0 0.2 0.39 11.3 0.2 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_004623.4_1 - 0.083 13.0 4.2 0.2 11.7 3.4 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.4 NM_004623.4_1 - 0.13 12.4 1.9 32 4.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat BolA PF01722.16 NM_016074.4_1 - 2.3e-27 95.0 0.0 3.1e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein Bim_N PF06773.9 NM_207002.3_1 - 7.5e-20 70.2 8.0 1.4e-19 69.4 8.0 1.5 1 0 0 1 1 1 1 Bim protein N-terminus TT_ORF1 PF02956.12 NM_207002.3_3 - 9.1 4.7 12.5 13 4.2 12.5 1.1 1 0 0 1 1 1 0 TT viral orf 1 Spectrin PF00435.19 NM_001322989.1_2 - 4.7e-40 136.2 80.1 1.5e-09 38.1 1.7 9.9 7 2 1 8 8 8 6 Spectrin repeat RhoGEF PF00621.18 NM_001322989.1_2 - 1.4e-36 126.3 0.5 1.4e-36 126.3 0.5 4.3 5 1 1 6 6 6 1 RhoGEF domain CRAL_TRIO_2 PF13716.4 NM_001322989.1_2 - 1.1e-07 31.9 0.0 2e-05 24.6 0.0 2.9 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 NM_001322989.1_2 - 7.7e-07 28.8 0.0 4.1e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 CRAL/TRIO domain PH PF00169.27 NM_001322989.1_2 - 2.5e-06 27.8 0.7 1.1e-05 25.7 0.1 2.4 2 0 0 2 2 2 1 PH domain PH_10 PF15411.4 NM_001322989.1_2 - 0.0039 17.3 0.1 0.023 14.8 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain HAD_2 PF13419.4 NM_001322989.1_2 - 3.3 7.6 7.4 18 5.3 0.0 3.9 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase ECR1_N PF14382.4 NM_014285.6_3 - 2.3e-15 55.9 0.7 3.9e-15 55.2 0.7 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.3 NM_014285.6_3 - 3.6e-13 49.5 0.0 6.9e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 KH domain zf-H2C2_2 PF13465.4 NM_004561.3_2 - 1.1e-15 57.1 26.0 1.1e-09 38.2 0.6 5.9 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 NM_004561.3_2 - 2.2e-11 43.4 35.7 0.00043 20.4 2.4 5.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_004561.3_2 - 2.7e-06 27.6 44.5 0.00087 19.8 1.4 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_004561.3_2 - 0.0042 16.7 13.0 0.71 9.6 0.2 4.0 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-met PF12874.5 NM_004561.3_2 - 0.76 10.1 22.6 0.091 13.0 2.4 4.0 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Pax2_C PF12403.6 NM_013952.3_1 - 7.6e-54 180.5 15.5 1.7e-53 179.4 15.5 1.6 1 0 0 1 1 1 1 Paired-box protein 2 C terminal PAX PF00292.16 NM_013952.3_2 - 1.1e-71 238.5 0.4 1.6e-71 238.0 0.4 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.4 NM_013952.3_2 - 0.0002 20.9 0.0 0.00041 19.9 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.4 NM_013952.3_2 - 0.13 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain EMI PF07546.11 NM_001278563.2_1 - 3.7e-17 62.7 11.3 7.4e-17 61.7 11.3 1.5 1 0 0 1 1 1 1 EMI domain Collagen PF01391.16 NM_001278563.2_1 - 2.7e-15 55.7 99.6 3e-09 36.3 32.1 4.9 4 1 0 4 4 4 2 Collagen triple helix repeat (20 copies) Varsurf_PPLC PF03490.11 NM_153268.3_1 - 0.0018 18.0 0.2 0.21 11.4 0.0 2.5 2 0 0 2 2 2 2 Variant-surface-glycoprotein phospholipase C 7tm_4 PF13853.4 NM_054106.1_1 - 5.5e-45 154.1 20.8 6.4e-45 153.9 20.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_054106.1_1 - 2.3e-18 66.3 17.0 4.9e-18 65.2 17.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DAGK_acc PF00609.17 NM_152910.5_1 - 6.2e-51 172.8 0.0 9.2e-51 172.2 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 NM_152910.5_1 - 9.5e-27 93.0 0.0 1.5e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 NM_152910.5_1 - 2.4e-17 62.4 26.2 1.2e-08 34.6 6.0 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 NM_152910.5_1 - 1.9e-14 53.9 0.6 3.3e-14 53.1 0.6 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 NM_152910.5_1 - 0.00043 20.4 0.3 0.00077 19.6 0.3 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 NM_152910.5_1 - 0.0035 17.6 0.6 0.0099 16.2 0.6 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain C1_2 PF03107.14 NM_152910.5_1 - 0.031 14.5 16.2 0.028 14.6 5.7 2.9 2 0 0 2 2 2 0 C1 domain MCLC PF05934.9 NM_001278202.1_3 - 6.9e-255 846.8 2.2 1.6e-186 621.2 0.0 2.1 1 1 1 2 2 2 2 Mid-1-related chloride channel (MCLC) PID PF00640.21 NM_001257320.2_1 - 7.4e-47 158.8 0.0 1.5e-38 131.8 0.0 2.3 2 1 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.24 NM_001257320.2_1 - 7.2e-06 25.7 3.0 7.2e-06 25.7 3.0 2.1 2 0 0 2 2 2 1 WW domain PTB PF08416.11 NM_001257320.2_1 - 1e-05 25.6 0.0 0.0001 22.3 0.0 2.1 2 0 0 2 2 2 1 Phosphotyrosine-binding domain PID_2 PF14719.4 NM_001257320.2_1 - 0.021 14.5 0.0 6.3 6.5 0.0 2.2 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) Calsarcin PF05556.9 NM_001166209.1_2 - 3e-07 30.0 0.0 0.0017 17.7 0.0 2.5 2 0 0 2 2 2 2 Calcineurin-binding protein (Calsarcin) Ldh_1_N PF00056.21 NM_001199112.1_1 - 0.08 12.9 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 NM_001199112.1_3 - 2.8e-45 154.1 0.0 7.1e-45 152.8 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.21 NM_001199112.1_3 - 1.5e-23 83.4 0.2 2.7e-23 82.5 0.2 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain DUF4809 PF16067.3 NM_001199112.1_3 - 0.043 13.9 0.2 0.32 11.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4809) MFS_1 PF07690.14 NM_001287498.1_2 - 7.6e-37 126.9 22.2 4.6e-31 107.9 18.6 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_001287498.1_2 - 1.1e-06 27.7 25.3 0.004 15.9 3.3 3.1 2 1 1 3 3 3 3 Sugar (and other) transporter DUF3534 PF12053.6 NM_001184785.1_1 - 1.2e-57 194.2 1.4 1.9e-57 193.5 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3534) PDZ PF00595.22 NM_001184785.1_1 - 9.1e-37 125.2 5.3 8.1e-16 58.0 0.2 3.6 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001184785.1_1 - 1.8e-13 50.5 0.5 1.8e-05 24.8 0.1 3.8 3 1 0 3 3 3 3 PDZ domain AlbA_2 PF04326.12 NM_001300859.1_1 - 4.3e-28 98.0 0.0 6.7e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 Putative DNA-binding domain bZIP_1 PF00170.19 NM_001300859.1_1 - 0.16 12.0 1.0 0.28 11.2 1.0 1.3 1 0 0 1 1 1 0 bZIP transcription factor Humanin PF15040.4 NM_001190476.1_1 - 3.9e-16 58.1 0.1 6.6e-16 57.4 0.1 1.4 1 0 0 1 1 1 1 Humanin family Peptidase_M16_M PF16187.3 NM_001322793.1_2 - 1.1e-102 343.0 3.5 1.9e-102 342.2 3.5 1.4 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.18 NM_001322793.1_2 - 9.8e-48 161.8 0.1 2.9e-46 157.0 0.0 2.4 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 NM_001322793.1_2 - 8.9e-39 133.3 0.1 5e-23 81.9 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Tn916-Xis PF09035.8 NM_001322793.1_2 - 0.11 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Excisionase from transposon Tn916 STT3 PF02516.12 NM_001278503.1_2 - 5.2e-165 549.9 41.3 2.4e-160 534.6 36.7 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.4 NM_001278503.1_2 - 7.1e-06 26.2 13.7 3e-05 24.2 13.7 2.1 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Y_phosphatase PF00102.25 NM_001199763.1_2 - 5.1e-74 248.7 0.0 6.8e-74 248.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RESP18 PF14948.4 NM_001199763.1_2 - 1e-33 115.7 0.8 1e-33 115.7 0.8 2.2 2 0 0 2 2 2 1 RESP18 domain Receptor_IA-2 PF11548.6 NM_001199763.1_2 - 2.6e-16 59.2 0.4 8.9e-16 57.5 0.2 1.9 1 1 1 2 2 2 1 Protein-tyrosine phosphatase receptor IA-2 DSPc PF00782.18 NM_001199763.1_2 - 0.063 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain RbsD_FucU PF05025.11 NM_198472.2_1 - 7e-35 120.2 0.0 1.9e-31 109.1 0.0 2.0 2 0 0 2 2 2 2 RbsD / FucU transport protein family IL17_R_N PF15037.4 NM_001193380.1_1 - 6.3e-131 436.9 0.9 3.1e-129 431.3 0.9 2.1 1 1 0 1 1 1 1 Interleukin-17 receptor extracellular region SEFIR PF08357.9 NM_001193380.1_2 - 2.7e-22 79.5 0.0 1.3e-14 54.6 0.0 2.1 2 0 0 2 2 2 2 SEFIR domain IL17_R_N PF15037.4 NM_001193380.1_2 - 0.001 18.0 0.3 0.0015 17.4 0.3 1.2 1 0 0 1 1 1 1 Interleukin-17 receptor extracellular region Y_phosphatase PF00102.25 NM_006906.1_3 - 5.9e-74 248.4 0.3 1e-73 247.7 0.3 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 NM_006906.1_3 - 0.00097 18.8 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_006906.1_3 - 0.029 14.2 0.0 0.055 13.3 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Vasohibin PF14822.4 NM_024749.4_3 - 2.6e-81 272.3 0.8 1.2e-56 191.5 0.1 2.1 1 1 1 2 2 2 2 Vasohibin NCOA_u2 PF16665.3 NM_181659.2_1 - 1.6e-43 147.6 18.0 1.6e-43 147.6 18.0 5.7 6 1 2 8 8 2 1 Unstructured region on nuclear receptor coactivator protein PAS_11 PF14598.4 NM_181659.2_1 - 2e-33 114.7 0.3 2.1e-32 111.4 0.0 3.1 3 0 0 3 3 2 2 PAS domain DUF4927 PF16279.3 NM_181659.2_1 - 4.3e-32 110.8 6.0 4.3e-32 110.8 6.0 2.5 2 0 0 2 2 1 1 Domain of unknown function (DUF4927) SRC-1 PF08832.8 NM_181659.2_1 - 1.5e-28 99.5 6.7 1.5e-28 99.5 6.7 3.7 5 0 0 5 5 1 1 Steroid receptor coactivator Nuc_rec_co-act PF08815.8 NM_181659.2_1 - 1.4e-24 85.6 2.5 2.6e-24 84.7 2.5 1.5 1 0 0 1 1 1 1 Nuclear receptor coactivator DUF1518 PF07469.10 NM_181659.2_1 - 1.8e-23 82.5 22.4 1.8e-23 82.5 22.4 6.0 5 2 0 5 5 3 1 Domain of unknown function (DUF1518) PAS PF00989.23 NM_181659.2_1 - 4.4e-08 33.0 3.9 4.9e-08 32.8 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.10 NM_181659.2_1 - 3.1e-06 27.2 0.1 0.00026 21.1 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.5 NM_181659.2_1 - 1.9e-05 24.7 0.1 4.7e-05 23.5 0.1 1.7 1 0 0 1 1 1 1 PAS domain HLH PF00010.24 NM_181659.2_1 - 0.0052 16.6 0.7 0.01 15.6 0.7 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain AIM3 PF17096.3 NM_181659.2_1 - 0.085 13.7 3.2 0.29 12.0 3.2 1.8 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 Spt20 PF12090.6 NM_181659.2_1 - 0.087 12.3 28.7 0.34 10.3 28.7 2.0 1 0 0 1 1 1 0 Spt20 family TERB2 PF15101.4 NM_181659.2_1 - 0.19 11.7 11.3 0.52 10.2 11.3 1.7 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PAS_4 PF08448.8 NM_181659.2_1 - 0.21 11.7 0.0 0.21 11.7 0.0 2.2 2 0 0 2 2 2 0 PAS fold Presenilin PF01080.15 NM_181659.2_1 - 0.62 8.6 6.7 1.6 7.2 6.7 1.6 1 0 0 1 1 1 0 Presenilin RNA_pol_Rbc25 PF08292.10 NM_181659.2_1 - 1.3 9.1 4.8 3.1 7.9 4.8 1.5 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 DUF4834 PF16118.3 NM_181659.2_1 - 6.7 7.6 10.9 27 5.7 10.9 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) FSA_C PF10479.7 NM_181659.2_3 - 5.5 4.9 10.2 7.6 4.4 10.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Bromodomain PF00439.23 NM_001242806.2_2 - 1e-41 140.7 6.1 2.2e-21 75.6 0.5 2.6 2 0 0 2 2 2 2 Bromodomain BET PF17035.3 NM_001242806.2_2 - 6.6e-28 96.6 0.1 2.3e-27 94.8 0.1 2.1 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRD4_CDT PF17105.3 NM_001242806.2_2 - 1.6e-22 78.7 5.3 4.8e-22 77.1 5.3 1.9 1 0 0 1 1 1 1 C-terminal domain of bromodomain protein 4 DUF2079 PF09852.7 NM_001242806.2_2 - 0.13 11.0 0.3 0.19 10.4 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) PDZ PF00595.22 NM_021021.3_2 - 3.4e-18 65.7 0.5 5.9e-18 64.9 0.5 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PH PF00169.27 NM_021021.3_2 - 1.6e-15 57.3 0.0 7e-11 42.4 0.0 2.7 3 0 0 3 3 3 2 PH domain PDZ_2 PF13180.4 NM_021021.3_2 - 0.0028 17.8 0.0 0.0049 17.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Myosin_head PF00063.19 NM_017433.4_1 - 1.3e-202 674.5 8.0 1.9e-202 674.0 8.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Pkinase PF00069.23 NM_017433.4_1 - 4.6e-61 206.4 0.0 9.5e-61 205.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_017433.4_1 - 4.6e-45 153.8 0.0 1.1e-44 152.5 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase IQ PF00612.25 NM_017433.4_1 - 1.3e-07 30.7 21.2 0.00024 20.5 0.2 4.4 4 0 0 4 4 4 3 IQ calmodulin-binding motif Kinase-like PF14531.4 NM_017433.4_1 - 0.00059 19.1 0.0 0.0015 17.8 0.0 1.6 1 0 0 1 1 1 1 Kinase-like AAA_22 PF13401.4 NM_017433.4_1 - 0.0086 16.2 0.0 0.032 14.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain APH PF01636.21 NM_017433.4_1 - 0.015 15.1 0.0 5.5 6.7 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Hpr_kinase_C PF07475.10 NM_017433.4_1 - 0.075 12.4 0.3 2.1 7.7 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Lsm_interact PF05391.9 NM_017433.4_3 - 0.14 11.6 0.0 0.3 10.5 0.0 1.6 1 0 0 1 1 1 0 Lsm interaction motif ApoL PF05461.9 NM_030641.3_1 - 9.3e-85 284.6 2.3 1.3e-84 284.2 2.3 1.1 1 0 0 1 1 1 1 Apolipoprotein L DHR-2 PF06920.11 NM_004947.4_3 - 2e-131 439.1 5.7 2e-131 439.1 5.7 2.0 2 0 0 2 2 2 1 Dock homology region 2 DOCK_N PF16172.3 NM_004947.4_3 - 1.8e-120 402.2 0.7 2.8e-120 401.6 0.7 1.3 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.4 NM_004947.4_3 - 6e-53 179.4 0.1 2e-52 177.7 0.0 2.0 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_2 PF07653.15 NM_004947.4_3 - 5.4e-05 22.7 0.2 0.00014 21.3 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_004947.4_3 - 0.028 14.2 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain MBOAT PF03062.17 NM_003578.3_2 - 9.7e-67 225.6 23.5 1.2e-66 225.3 23.5 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.4 NM_003578.3_2 - 0.096 12.9 6.9 0.058 13.5 3.5 2.5 2 0 0 2 2 2 0 Membrane bound O-acyl transferase family Serpin PF00079.18 NM_006215.3_3 - 3.7e-108 362.0 0.2 4.3e-108 361.8 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) WD40 PF00400.30 NM_001139467.1_2 - 1.2e-48 161.9 25.9 1.1e-09 38.6 0.2 8.8 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001139467.1_2 - 2.4e-26 91.7 1.9 1.5e-07 31.5 0.0 6.0 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.9 NM_001139467.1_2 - 5.6e-09 35.5 0.1 1.6e-08 34.1 0.1 1.8 2 0 0 2 2 2 1 LisH WD40_like PF17005.3 NM_001139467.1_2 - 0.017 14.4 0.0 4.5 6.4 0.0 2.5 2 0 0 2 2 2 0 WD40-like domain Ge1_WD40 PF16529.3 NM_001139467.1_2 - 0.018 13.9 0.5 10 4.9 0.0 3.1 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Shadoo PF14999.4 NM_001139467.1_2 - 0.39 10.7 4.3 0.78 9.7 4.3 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective K_channel_TID PF07941.9 NM_001139467.1_2 - 4.7 7.6 16.0 0.039 14.3 7.7 1.8 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain RhoGEF PF00621.18 NM_001258206.1_3 - 3.9e-41 141.2 4.2 3.9e-41 141.2 4.2 1.9 2 0 0 2 2 2 1 RhoGEF domain CAMSAP_CH PF11971.6 NM_001258206.1_3 - 1.5e-21 75.9 0.5 4.1e-21 74.5 0.1 2.0 2 0 0 2 2 2 1 CAMSAP CH domain CH PF00307.29 NM_001258206.1_3 - 1.1e-20 73.7 2.4 3.6e-20 72.1 0.1 2.7 3 0 0 3 3 3 1 Calponin homology (CH) domain SH3_1 PF00018.26 NM_001258206.1_3 - 1e-18 66.5 5.1 3.6e-16 58.4 0.2 2.8 3 0 0 3 3 3 2 SH3 domain SH3_2 PF07653.15 NM_001258206.1_3 - 3.3e-18 65.0 0.3 1.8e-13 49.8 0.1 3.1 3 0 0 3 3 3 2 Variant SH3 domain SH2 PF00017.22 NM_001258206.1_3 - 1.8e-17 63.0 0.0 4.7e-17 61.7 0.0 1.8 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.4 NM_001258206.1_3 - 6.2e-16 57.8 0.3 1.1e-12 47.4 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.20 NM_001258206.1_3 - 5e-11 42.2 6.4 1.1e-10 41.1 6.4 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 NM_001258206.1_3 - 2.9e-09 37.3 0.2 6.3e-09 36.1 0.2 1.6 1 0 0 1 1 1 1 PH domain CDC24 PF06395.9 NM_001258206.1_3 - 3.3e-05 24.0 0.1 0.00018 21.6 0.1 2.3 2 0 0 2 2 1 1 CDC24 Calponin C1_2 PF03107.14 NM_001258206.1_3 - 0.0006 19.9 4.3 0.0014 18.7 4.3 1.7 1 0 0 1 1 1 1 C1 domain DUF3104 PF11302.6 NM_001258206.1_3 - 0.049 13.2 0.3 6.2 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3104) DUF4335 PF14233.4 NM_001258206.1_3 - 0.08 12.7 0.4 0.17 11.7 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4335) Lipase PF00151.17 NM_001293225.1_2 - 1.3e-102 343.5 0.0 1.8e-102 342.9 0.0 1.2 1 0 0 1 1 1 1 Lipase SecE PF00584.18 NM_001012456.1_2 - 2.2e-14 53.0 0.9 2.7e-14 52.7 0.1 1.6 2 0 0 2 2 2 1 SecE/Sec61-gamma subunits of protein translocation complex RRM_1 PF00076.20 NM_001286627.1_3 - 2.7e-15 55.8 0.0 4.4e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001286627.1_3 - 0.0015 18.4 0.0 0.003 17.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Macoilin PF09726.7 NM_001286627.1_3 - 0.0089 14.5 20.3 0.012 14.1 20.3 1.1 1 0 0 1 1 1 1 Transmembrane protein Nup35_RRM_2 PF14605.4 NM_001286627.1_3 - 0.011 15.5 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif MIP-T3 PF10243.7 NM_001286627.1_3 - 0.059 12.0 21.9 0.079 11.5 21.9 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 RRM_3 PF08777.9 NM_001286627.1_3 - 0.096 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif SOG2 PF10428.7 NM_001286627.1_3 - 0.7 8.9 24.8 0.99 8.5 24.8 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein LAP1C PF05609.10 NM_001286627.1_3 - 3.1 6.6 15.2 4.5 6.1 15.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SPX PF03105.17 NM_001286627.1_3 - 3.3 7.4 31.4 5.1 6.8 31.4 1.2 1 0 0 1 1 1 0 SPX domain PI3K_1B_p101 PF10486.7 NM_001286627.1_3 - 6.8 4.2 18.3 9.3 3.7 18.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit FYVE_2 PF02318.14 NM_182935.3_2 - 2.5e-09 37.2 4.8 2.5e-09 37.2 4.8 2.1 2 0 0 2 2 2 1 FYVE-type zinc finger Y_phosphatase PF00102.25 NM_130854.2_1 - 9.7e-168 555.4 0.5 1.6e-84 283.0 0.0 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.19 NM_130854.2_1 - 1.7e-108 355.0 15.2 5e-16 58.7 0.0 9.4 9 0 0 9 9 9 8 Fibronectin type III domain I-set PF07679.14 NM_130854.2_1 - 3.4e-41 139.1 0.0 2e-16 59.7 0.0 3.9 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_130854.2_1 - 2.5e-38 130.4 2.6 1.1e-11 45.0 0.0 6.0 6 0 0 6 6 6 3 Immunoglobulin domain Ig_2 PF13895.4 NM_130854.2_1 - 1.7e-22 79.4 0.1 8e-08 32.4 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 NM_130854.2_1 - 1e-16 61.1 4.2 0.066 13.7 0.0 9.5 9 2 0 9 9 9 4 Purple acid Phosphatase, N-terminal domain ig PF00047.23 NM_130854.2_1 - 4.9e-16 58.5 0.0 0.002 18.1 0.0 5.2 5 0 0 5 5 5 3 Immunoglobulin domain DSPc PF00782.18 NM_130854.2_1 - 2e-08 34.0 0.0 0.0092 15.7 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Interfer-bind PF09294.8 NM_130854.2_1 - 6.5e-08 32.7 0.0 0.68 10.1 0.0 5.8 5 0 0 5 5 5 1 Interferon-alpha/beta receptor, fibronectin type III V-set PF07686.15 NM_130854.2_1 - 7.1e-07 29.2 1.4 1.6 8.7 0.0 6.1 5 2 1 6 6 6 2 Immunoglobulin V-set domain Y_phosphatase3 PF13350.4 NM_130854.2_1 - 8.8e-07 29.0 0.0 0.045 13.6 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_130854.2_1 - 3.5e-05 23.8 0.0 0.013 15.6 0.0 2.6 2 0 0 2 2 2 1 Inositol hexakisphosphate C2-set_2 PF08205.10 NM_130854.2_1 - 4.4e-05 23.3 0.0 1.2 9.2 0.0 3.7 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain DUF2369 PF10179.7 NM_130854.2_1 - 0.0036 17.6 0.4 1.2e+02 3.2 0.0 5.6 7 0 0 7 7 5 0 Uncharacterised conserved protein (DUF2369) Pkinase PF00069.23 NM_019884.2_3 - 9.6e-70 234.8 0.0 1.1e-69 234.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_019884.2_3 - 2e-25 89.5 0.0 2.8e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_019884.2_3 - 0.00013 21.3 0.0 0.0034 16.6 0.0 2.1 1 1 1 2 2 2 1 Kinase-like APH PF01636.21 NM_019884.2_3 - 0.0049 16.7 0.0 0.021 14.6 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 NM_019884.2_3 - 0.061 12.5 0.0 0.094 11.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PDZ PF00595.22 NM_018968.3_1 - 1.1e-16 60.8 0.6 1.9e-16 60.1 0.6 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_018968.3_1 - 4.3e-05 23.6 0.1 9.6e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 NM_018968.3_1 - 0.069 13.0 0.8 0.34 10.8 0.1 2.2 2 0 0 2 2 2 0 Tricorn protease PDZ domain PaaSYMP PF14738.4 NM_001320316.1_1 - 3.6e-64 215.3 12.3 3.6e-64 215.3 12.3 3.2 2 1 1 3 3 3 1 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1 Sarcoglycan_1 PF04790.11 NM_000231.2_3 - 2.7e-81 272.6 0.0 3.6e-81 272.2 0.0 1.1 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.7 NM_000231.2_3 - 0.012 15.3 0.0 0.055 13.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2345) PRY PF13765.4 NM_203295.1_1 - 7.6e-18 63.7 0.2 1.5e-17 62.8 0.2 1.6 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 NM_203295.1_1 - 2e-14 53.6 0.0 3.6e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 SPRY domain Methyltr_RsmB-F PF01189.15 NM_001258309.1_2 - 9.6e-84 279.9 0.0 1.5e-83 279.2 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F P120R PF08062.9 NM_001258309.1_2 - 9.4e-22 76.1 31.8 3.9e-08 33.1 1.1 4.0 3 0 0 3 3 3 3 P120R (NUC006) repeat Methyltr_RsmF_N PF17125.3 NM_001258309.1_2 - 1e-09 38.6 0.0 2.7e-09 37.2 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.17 NM_001258309.1_2 - 0.0018 18.3 0.0 0.0036 17.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.17 NM_001258309.1_2 - 0.0024 17.5 0.0 0.0044 16.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.4 NM_001258309.1_2 - 0.0032 18.0 0.0 0.0077 16.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001258309.1_2 - 0.026 14.2 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Prefoldin_2 PF01920.18 NM_001258309.1_2 - 0.047 13.5 0.5 0.38 10.6 0.0 2.2 2 0 0 2 2 2 0 Prefoldin subunit DUF2431 PF10354.7 NM_001258309.1_2 - 0.086 13.0 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) Met_10 PF02475.14 NM_001258309.1_2 - 0.11 12.1 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_15 PF09445.8 NM_001258309.1_2 - 0.19 11.4 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DUF498 PF04430.12 NM_001316962.1_3 - 3.2e-20 72.1 0.0 4e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Metallophos PF00149.26 NM_001584.2_1 - 1.4e-10 41.9 0.8 2e-10 41.4 0.8 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 NM_001584.2_1 - 0.0077 16.3 0.0 0.094 12.8 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SH3_9 PF14604.4 NM_001284313.1_2 - 3e-10 39.7 0.2 5.4e-10 38.8 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001284313.1_2 - 3.5e-10 39.2 0.2 8.3e-10 38.0 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001284313.1_2 - 1.9e-05 24.1 0.0 4.1e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Cofilin_ADF PF00241.18 NM_001284313.1_2 - 0.02 14.9 0.0 0.039 14.0 0.0 1.5 1 0 0 1 1 1 0 Cofilin/tropomyosin-type actin-binding protein RR_TM4-6 PF06459.10 NM_001284313.1_2 - 5.4 6.6 9.9 8.2 6.0 9.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobW_C PF07683.12 NM_001284313.1_3 - 0.11 12.3 0.3 0.23 11.3 0.3 1.4 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain PAS_11 PF14598.4 NM_001248005.1_1 - 4.6e-26 91.0 0.0 6.3e-21 74.5 0.0 2.3 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.10 NM_001248005.1_1 - 3.5e-20 71.9 0.0 9.1e-14 51.4 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 NM_001248005.1_1 - 3e-18 65.7 0.0 6.6e-09 35.6 0.0 2.3 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 NM_001248005.1_1 - 4.8e-14 51.9 1.7 8.3e-14 51.2 1.7 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 NM_001248005.1_1 - 3.7e-10 39.8 0.0 2.3e-05 24.5 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 NM_001248005.1_1 - 0.00016 21.8 0.0 0.087 12.9 0.0 2.4 2 0 0 2 2 2 2 PAS fold Glyco_transf_29 PF00777.16 NM_013305.5_2 - 2.4e-76 256.6 0.0 3.1e-76 256.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) SIT PF15330.4 NM_001289087.1_1 - 2e-17 63.5 0.1 3.3e-17 62.8 0.1 1.3 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT V-set PF07686.15 NM_001289087.1_3 - 6e-12 45.6 0.9 8.7e-12 45.0 0.9 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain SIT PF15330.4 NM_001289087.1_3 - 1.5e-08 34.9 0.3 2.6e-08 34.1 0.3 1.4 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT TMEM154 PF15102.4 NM_001289087.1_3 - 0.2 11.4 0.0 0.31 10.8 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family ig PF00047.23 NM_001289087.1_3 - 0.22 11.6 3.0 1.2 9.2 3.0 2.0 1 1 0 1 1 1 0 Immunoglobulin domain RPN7 PF10602.7 NM_014814.2_2 - 9.8e-62 207.6 2.2 1.4e-61 207.1 2.2 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.25 NM_014814.2_2 - 3e-17 62.9 0.2 9.2e-17 61.4 0.0 1.9 2 0 0 2 2 2 1 PCI domain STOP PF05217.10 NM_153707.3_3 - 0.0014 18.7 7.0 0.0014 18.7 7.0 3.4 3 0 0 3 3 3 1 STOP protein NAD_Gly3P_dh_N PF01210.21 NM_005276.3_2 - 2.1e-54 183.6 0.1 3.8e-54 182.8 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.12 NM_005276.3_2 - 3e-48 163.6 0.1 4.4e-48 163.0 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.15 NM_005276.3_2 - 0.014 15.8 0.6 1.2 9.7 0.0 2.5 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.17 NM_005276.3_2 - 0.13 11.4 0.1 0.24 10.6 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain EF-hand_1 PF00036.30 NM_006471.3_3 - 1.6e-13 49.0 6.3 4e-07 29.0 1.6 4.3 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 NM_006471.3_3 - 1e-12 48.2 4.5 2.7e-07 30.8 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_006471.3_3 - 1.2e-10 40.3 7.3 2.5e-07 30.0 0.9 3.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 NM_006471.3_3 - 5.8e-08 32.3 4.4 0.0054 16.3 0.2 3.3 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 NM_006471.3_3 - 1.9e-05 23.8 2.3 5.2e-05 22.5 1.5 2.1 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.9 NM_006471.3_3 - 2.5e-05 24.9 0.2 0.00028 21.6 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain EF-hand_9 PF14658.4 NM_006471.3_3 - 0.0083 16.3 0.0 1.5 9.1 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain UPF0154 PF03672.11 NM_006471.3_3 - 0.01 15.7 0.0 4.6 7.2 0.0 3.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) GPHH PF16905.3 NM_006471.3_3 - 0.015 15.0 0.0 3 7.6 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated SPARC_Ca_bdg PF10591.7 NM_006471.3_3 - 0.059 13.5 0.3 0.11 12.6 0.3 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Serpin PF00079.18 NM_002575.2_1 - 4e-130 434.3 0.1 4.7e-130 434.1 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) GDE_C PF06202.12 NM_002575.2_1 - 0.091 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase ADH_zinc_N_2 PF13602.4 NM_014985.3_2 - 0.14 13.1 0.2 0.4 11.6 0.2 1.8 1 0 0 1 1 1 0 Zinc-binding dehydrogenase zf-H2C2_2 PF13465.4 NM_005341.3_3 - 1.8e-53 176.5 86.8 2.2e-09 37.2 2.0 12.5 12 0 0 12 12 12 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_005341.3_3 - 1.4e-34 116.4 92.0 8.7e-06 25.8 1.9 11.6 11 0 0 11 11 11 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_005341.3_3 - 1.8e-27 93.5 94.9 0.0029 18.2 1.6 12.0 12 0 0 12 12 11 10 C2H2-type zinc finger BTB PF00651.29 NM_005341.3_3 - 4.3e-22 78.3 0.0 7.1e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-Di19 PF05605.10 NM_005341.3_3 - 1.2e-07 31.7 65.5 0.00096 19.3 2.0 7.5 3 2 5 8 8 8 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 NM_005341.3_3 - 5.9e-07 29.2 70.8 2.6e-05 23.9 1.2 10.3 10 0 0 10 10 10 5 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_005341.3_3 - 3.5e-05 23.3 4.8 0.00017 21.2 0.6 8.2 10 0 0 10 10 9 2 zinc-finger C2H2-type zf-met PF12874.5 NM_005341.3_3 - 0.00019 21.5 64.0 0.22 11.8 1.5 10.7 11 0 0 11 11 10 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_005341.3_3 - 0.00021 21.4 55.9 0.01 16.0 0.5 10.0 11 0 0 11 11 11 3 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 NM_005341.3_3 - 0.00053 19.5 6.1 0.0052 16.4 0.6 8.1 9 0 0 9 9 9 4 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.3 NM_005341.3_3 - 0.0017 18.4 47.3 0.57 10.4 3.3 6.2 1 1 4 5 5 5 4 C2H2-type zinc ribbon DUF3268 PF11672.6 NM_005341.3_3 - 0.027 14.7 25.8 1.5 9.0 0.3 5.4 5 0 0 5 5 5 0 zinc-finger-containing domain DRTGG PF07085.10 NM_005341.3_3 - 0.12 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 DRTGG domain zinc_ribbon_15 PF17032.3 NM_005341.3_3 - 0.51 11.0 39.6 6.5 7.4 0.4 5.8 3 1 3 6 6 6 0 zinc-ribbon family Zn-ribbon_8 PF09723.8 NM_005341.3_3 - 1.2 9.2 56.3 0.3 11.1 3.1 8.6 7 2 2 9 9 9 0 Zinc ribbon domain YEATS PF03366.14 NM_018023.4_1 - 6.2e-25 86.9 0.7 1.4e-24 85.8 0.7 1.5 1 0 0 1 1 1 1 YEATS family ATG16 PF08614.9 NM_203356.2_3 - 0.0063 16.6 72.0 0.012 15.7 23.7 4.3 1 1 3 4 4 4 2 Autophagy protein 16 (ATG16) IncA PF04156.12 NM_203356.2_3 - 0.14 11.8 75.5 0.27 10.9 15.7 4.7 1 1 3 5 5 5 0 IncA protein NPIP PF06409.9 NM_203356.2_3 - 0.26 10.4 17.4 0.0076 15.4 7.6 2.6 3 0 0 3 3 3 0 Nuclear pore complex interacting protein (NPIP) Reo_sigmaC PF04582.10 NM_203356.2_3 - 1.4 8.1 14.2 1.1 8.5 1.9 2.5 2 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF3584 PF12128.6 NM_203356.2_3 - 6.6 4.0 57.3 20 2.3 57.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) CC2-LZ PF16516.3 NM_001258455.1_1 - 3.6e-07 30.3 22.0 3.6e-07 30.3 22.0 5.8 4 1 1 5 5 5 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FlxA PF14282.4 NM_001258455.1_1 - 0.00074 19.3 5.2 0.00074 19.3 5.2 4.7 4 1 1 5 5 5 2 FlxA-like protein DUF4407 PF14362.4 NM_001258455.1_1 - 0.4 9.8 47.0 8.6 5.5 34.2 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.10 NM_001258455.1_1 - 6.4 7.2 18.8 4.1 7.8 0.7 4.5 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein CENP-T_C PF15511.4 NM_003538.3_1 - 2.3e-08 34.0 0.1 2.8e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.15 NM_003538.3_1 - 3.6e-05 23.7 0.1 5e-05 23.3 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.4 NM_003538.3_1 - 6.8e-05 23.0 0.1 9.4e-05 22.6 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.22 NM_003538.3_1 - 0.0003 21.1 0.3 0.00034 20.9 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_003538.3_1 - 0.00041 20.4 0.1 0.00068 19.7 0.1 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.13 NM_003538.3_1 - 0.0077 16.2 0.0 0.009 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.11 NM_003538.3_1 - 0.033 14.0 0.0 0.052 13.4 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated Reticulon PF02453.15 NM_001321861.1_2 - 2.6e-46 157.3 6.7 3.9e-46 156.7 6.7 1.3 1 0 0 1 1 1 1 Reticulon DUF639 PF04842.10 NM_001321861.1_2 - 0.066 12.5 2.1 0.15 11.3 2.1 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) ICAT PF06384.9 NM_001316974.1_1 - 2.8e-33 113.9 0.5 2.8e-33 113.9 0.5 1.7 2 0 0 2 2 2 1 Beta-catenin-interacting protein ICAT CAMP_factor PF07373.9 NM_001316974.1_1 - 0.008 15.7 0.9 0.012 15.1 0.9 1.2 1 0 0 1 1 1 1 CAMP factor (Cfa) Serine_rich PF08824.8 NM_001316974.1_1 - 0.02 14.8 1.1 0.031 14.1 1.1 1.2 1 0 0 1 1 1 0 Serine rich protein interaction domain IncA PF04156.12 NM_001316974.1_1 - 0.03 14.0 4.9 0.065 12.9 4.9 1.4 1 0 0 1 1 1 0 IncA protein DUF2408 PF10303.7 NM_001316974.1_1 - 0.063 13.7 2.7 0.12 12.8 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) DUF3313 PF11769.6 NM_001316974.1_1 - 0.18 11.6 0.1 0.29 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) Swi5 PF07061.9 NM_001316974.1_1 - 0.38 10.7 2.0 0.71 9.8 2.0 1.4 1 0 0 1 1 1 0 Swi5 GvpG PF05120.10 NM_001316974.1_1 - 1.6 8.6 12.2 0.13 12.2 0.8 2.3 2 0 0 2 2 2 0 Gas vesicle protein G FlxA PF14282.4 NM_001316974.1_1 - 2.6 7.9 9.1 2.5 8.0 7.7 1.6 1 1 0 1 1 1 0 FlxA-like protein AHSA1 PF08327.9 NM_152392.4_1 - 0.005 16.9 0.1 0.01 15.9 0.1 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Aha1_N PF09229.9 NM_152392.4_2 - 3.1e-22 79.1 0.5 4.3e-22 78.6 0.5 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal FGGY_N PF00370.19 NM_000167.5_3 - 1.3e-90 303.1 0.0 2.2e-90 302.4 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.14 NM_000167.5_3 - 7.2e-64 215.0 0.1 1.2e-63 214.3 0.1 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain TPR_2 PF07719.15 NM_001289759.1_3 - 2.8e-19 67.5 15.5 0.00053 19.8 0.0 8.1 9 0 0 9 9 7 4 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001289759.1_3 - 5.3e-16 58.8 0.6 4.2e-05 23.8 0.0 4.1 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001289759.1_3 - 8.4e-16 56.7 21.9 0.014 15.4 0.0 8.5 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001289759.1_3 - 5.8e-12 45.6 7.9 7.6e-07 29.2 2.6 4.7 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001289759.1_3 - 1.2e-11 44.0 14.7 0.0022 17.5 0.1 6.4 6 0 0 6 6 6 3 TPR repeat TPR_14 PF13428.4 NM_001289759.1_3 - 1.2e-11 44.2 2.1 0.0013 19.2 0.0 6.9 4 3 3 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001289759.1_3 - 1.5e-11 43.7 17.9 0.024 14.8 0.0 8.6 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001289759.1_3 - 1.5e-11 43.5 27.9 0.0025 17.4 0.0 8.0 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001289759.1_3 - 5.1e-10 38.5 3.7 0.0019 17.9 0.0 5.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001289759.1_3 - 4.5e-07 30.3 0.2 0.31 11.6 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001289759.1_3 - 3.7e-06 27.1 3.0 0.04 14.4 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat NARP1 PF12569.6 NM_001289759.1_3 - 6.3e-05 21.9 1.9 0.0015 17.4 0.0 3.3 1 1 1 3 3 3 1 NMDA receptor-regulated protein 1 TPR_15 PF13429.4 NM_001289759.1_3 - 7.7e-05 21.9 0.4 0.19 10.8 0.0 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat Cohesin_load PF10345.7 NM_001289759.1_3 - 0.0023 16.3 3.5 0.022 13.1 0.0 3.0 3 0 0 3 3 3 1 Cohesin loading factor PUL PF08324.9 NM_001289759.1_3 - 0.005 16.0 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 PUL domain TPR_10 PF13374.4 NM_001289759.1_3 - 0.0093 15.7 9.0 5.2 7.0 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat ChAPs PF09295.8 NM_001289759.1_3 - 0.037 12.9 0.0 0.064 12.1 0.0 1.3 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_4 PF07721.12 NM_001289759.1_3 - 0.064 13.8 0.0 38 5.2 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001289759.1_3 - 0.084 12.9 1.0 15 5.7 0.1 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.7 NM_001289759.1_3 - 0.22 11.0 1.4 2 7.9 0.0 2.7 3 0 0 3 3 3 0 26S proteasome subunit RPN7 ANAPC3 PF12895.5 NM_001289759.1_3 - 0.23 11.5 9.8 0.95 9.6 0.1 4.6 3 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Sec1 PF00995.21 NM_001279353.1_3 - 1.2e-102 344.8 5.9 4.6e-83 280.2 0.2 2.1 1 1 1 2 2 2 2 Sec1 family COG5 PF10392.7 NM_181733.2_1 - 3.6e-33 114.4 1.7 3.6e-33 114.4 1.7 2.0 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Vps51 PF08700.9 NM_181733.2_1 - 9.7e-10 38.3 0.4 3.6e-09 36.4 0.2 2.2 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.9 NM_181733.2_1 - 8.8e-05 22.5 3.7 0.00041 20.3 0.3 2.8 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3800 PF12686.5 NM_181733.2_1 - 0.01 15.4 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) AceK PF06315.9 NM_181733.2_1 - 0.091 11.1 0.1 0.15 10.4 0.1 1.2 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) Cadherin_C PF01049.15 NM_004949.4_1 - 9.8e-06 25.8 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin PF00028.15 NM_004949.4_3 - 9.8e-72 237.3 4.4 7.4e-19 67.9 0.9 5.3 5 0 0 5 5 5 4 Cadherin domain Cadherin_pro PF08758.9 NM_004949.4_3 - 3.1e-18 65.6 0.6 1e-16 60.7 0.1 3.2 3 0 0 3 3 3 1 Cadherin prodomain like Cadherin_2 PF08266.10 NM_004949.4_3 - 0.005 16.5 0.0 8.5 6.1 0.0 3.8 4 0 0 4 4 4 1 Cadherin-like Cadherin_3 PF16184.3 NM_004949.4_3 - 0.015 15.2 6.0 2.1 8.2 0.6 3.9 4 0 0 4 4 4 0 Cadherin-like He_PIG PF05345.10 NM_004949.4_3 - 0.16 12.1 0.8 1.6 8.8 0.0 2.9 3 0 0 3 3 3 0 Putative Ig domain PH PF00169.27 NM_001161354.1_3 - 5.7e-16 58.8 0.0 9.7e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_001161354.1_3 - 0.00012 22.3 0.1 0.0026 18.0 0.3 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.4 NM_001161354.1_3 - 0.011 15.9 0.0 0.029 14.5 0.0 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain UPAR_LY6 PF00021.19 NM_001288763.1_3 - 6.7e-13 49.0 9.7 6.7e-13 49.0 9.7 3.4 3 1 1 4 4 4 1 u-PAR/Ly-6 domain DUF4407 PF14362.4 NM_020524.3_3 - 0.023 13.9 9.2 0.075 12.2 9.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) RasGAP_C PF03836.13 NM_020524.3_3 - 0.03 14.4 1.2 0.18 11.8 1.2 2.2 1 1 0 1 1 1 0 RasGAP C-terminus TPR_MLP1_2 PF07926.10 NM_020524.3_3 - 0.077 12.9 18.6 0.023 14.6 2.0 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF972 PF06156.11 NM_020524.3_3 - 0.091 13.3 10.0 0.13 12.7 4.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) IncA PF04156.12 NM_020524.3_3 - 0.42 10.2 28.9 2.4 7.8 28.9 2.1 1 1 1 2 2 2 0 IncA protein HAUS5 PF14817.4 NM_020524.3_3 - 1.3 7.4 16.9 1.8 6.9 5.6 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 5 HAP1_N PF04849.11 NM_020524.3_3 - 2.9 6.9 15.3 0.13 11.3 8.2 1.9 2 0 0 2 2 2 0 HAP1 N-terminal conserved region BRE1 PF08647.9 NM_020524.3_3 - 3.6 7.6 14.8 3.5 7.6 1.7 2.3 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF4763 PF15960.3 NM_020524.3_3 - 5.9 6.0 16.1 0.27 10.4 7.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Wtap PF17098.3 NM_020524.3_3 - 6.2 6.6 14.0 0.72 9.7 7.0 2.2 2 0 0 2 2 2 0 WTAP/Mum2p family Cortex-I_coil PF09304.8 NM_020524.3_3 - 7.7 6.6 11.6 3.5 7.7 0.6 2.6 2 0 0 2 2 2 0 Cortexillin I, coiled coil IL8 PF00048.18 NM_001291470.1_2 - 2.9e-17 62.4 0.2 1e-07 31.8 0.3 2.3 2 0 0 2 2 2 2 Small cytokines (intecrine/chemokine), interleukin-8 like Ras PF00071.20 NM_001256276.1_1 - 3.1e-34 117.8 0.1 4.2e-34 117.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001256276.1_1 - 1.2e-18 67.3 0.0 2e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001256276.1_1 - 1.1e-09 37.8 0.0 1.6e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Med19 PF10278.7 NM_145025.4_1 - 4.8 6.9 10.6 7.1 6.4 10.6 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 ADK PF00406.20 NM_145025.4_3 - 4.7e-19 68.8 0.6 6.8e-18 65.1 0.1 2.2 2 0 0 2 2 2 1 Adenylate kinase AAA_18 PF13238.4 NM_145025.4_3 - 1.1e-07 32.2 0.2 0.0067 16.8 0.0 3.5 2 1 0 2 2 2 2 AAA domain AAA_17 PF13207.4 NM_145025.4_3 - 2e-07 31.4 3.0 4.2e-05 23.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA PF00004.27 NM_145025.4_3 - 1.2e-05 25.6 0.0 0.008 16.5 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.21 NM_145025.4_3 - 4.6e-05 23.3 0.5 0.15 12.0 0.0 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_16 PF13191.4 NM_145025.4_3 - 7.3e-05 23.1 0.0 0.14 12.4 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.4 NM_145025.4_3 - 8.5e-05 22.7 0.0 0.046 13.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.25 NM_145025.4_3 - 8.8e-05 22.9 1.3 0.74 10.2 0.0 3.0 2 1 0 2 2 2 2 ABC transporter NACHT PF05729.10 NM_145025.4_3 - 0.00021 21.1 0.0 0.0052 16.6 0.0 2.5 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.20 NM_145025.4_3 - 0.00032 20.9 0.5 0.41 10.9 0.0 3.0 3 0 0 3 3 3 1 RNA helicase AAA_24 PF13479.4 NM_145025.4_3 - 0.0007 19.2 3.4 0.15 11.6 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.4 NM_145025.4_3 - 0.0017 18.5 1.6 1 9.5 0.0 2.6 3 0 0 3 3 2 2 AAA domain NTPase_1 PF03266.13 NM_145025.4_3 - 0.0026 17.6 0.2 1.1 9.0 0.0 2.4 2 0 0 2 2 2 1 NTPase RuvB_N PF05496.10 NM_145025.4_3 - 0.0034 16.5 0.0 0.2 10.7 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 NM_145025.4_3 - 0.0051 16.7 0.6 0.12 12.2 0.0 2.7 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.4 NM_145025.4_3 - 0.0058 16.7 0.1 0.24 11.4 0.0 2.6 3 0 0 3 3 2 1 AAA domain PduV-EutP PF10662.7 NM_145025.4_3 - 0.013 15.1 0.0 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.16 NM_145025.4_3 - 0.013 15.3 6.0 1 9.1 0.0 3.1 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea Roc PF08477.11 NM_145025.4_3 - 0.019 15.1 0.1 4.2 7.5 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Zeta_toxin PF06414.10 NM_145025.4_3 - 0.03 13.5 0.0 0.41 9.8 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.4 NM_145025.4_3 - 0.043 13.4 0.0 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.4 NM_145025.4_3 - 0.064 13.2 1.6 2.3 8.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain DUF258 PF03193.14 NM_145025.4_3 - 0.13 12.1 0.0 4 7.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 TsaE PF02367.15 NM_145025.4_3 - 0.14 12.1 0.0 2.2 8.2 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sulfotransfer_3 PF13469.4 NM_145025.4_3 - 0.15 12.3 0.1 16 5.7 0.3 2.3 2 0 0 2 2 2 0 Sulfotransferase family AAA_19 PF13245.4 NM_145025.4_3 - 0.15 12.3 2.1 1.4 9.1 2.3 2.3 2 1 0 2 2 1 0 AAA domain CDT1_C PF16679.3 NM_145025.4_3 - 0.2 12.0 0.7 0.44 10.8 0.7 1.5 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain AAA_13 PF13166.4 NM_145025.4_3 - 0.33 9.4 6.8 3.5 6.0 0.1 2.9 3 0 0 3 3 3 0 AAA domain MAS20 PF02064.13 NM_145025.4_3 - 0.51 10.3 4.7 0.89 9.5 4.7 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor PNMA PF14893.4 NM_032040.4_1 - 3.6e-26 92.2 0.1 3.6e-26 92.2 0.1 1.8 2 0 0 2 2 2 1 PNMA PIG-P PF08510.10 NM_153681.2_1 - 4.2e-40 136.3 2.6 6.2e-40 135.8 2.6 1.3 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.10 NM_153681.2_1 - 0.0018 18.4 6.3 0.0036 17.4 6.3 1.5 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Phage_holin_3_6 PF07332.9 NM_153681.2_1 - 0.089 12.7 0.5 0.16 11.9 0.5 1.4 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III FAM53 PF15242.4 NM_001174070.2_3 - 4e-92 309.2 22.5 7.3e-92 308.3 22.5 1.4 1 0 0 1 1 1 1 Family of FAM53 SWIM PF04434.15 NM_001174070.2_3 - 0.21 11.2 6.2 4.4 6.9 0.0 3.4 3 0 0 3 3 3 0 SWIM zinc finger DUF902 PF06001.11 NM_001136001.1_1 - 0.28 11.6 2.7 0.68 10.3 2.7 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF902) Pkinase_Tyr PF07714.15 NM_001136001.1_3 - 4.9e-98 327.4 0.0 6.6e-98 327.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001136001.1_3 - 9.5e-47 159.4 0.0 1.6e-46 158.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 NM_001136001.1_3 - 1.3e-24 85.9 0.1 2.7e-24 84.9 0.1 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 NM_001136001.1_3 - 2.1e-12 46.3 0.0 3.6e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001136001.1_3 - 2.3e-07 30.3 0.0 4.8e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_001136001.1_3 - 2.9e-07 30.1 0.0 5.1e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 NM_001136001.1_3 - 1.4e-05 25.1 0.5 4.6e-05 23.5 0.7 1.8 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_6 PF12913.5 NM_001136001.1_3 - 0.026 13.9 0.0 0.052 13.0 0.0 1.5 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) AAA_18 PF13238.4 NM_001289117.1_3 - 2e-13 50.9 0.0 3.3e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.21 NM_001289117.1_3 - 0.0018 18.2 0.0 0.086 12.8 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.4 NM_001289117.1_3 - 0.022 14.8 0.0 0.049 13.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain Striatin PF08232.10 NM_001083893.1_1 - 2.7e-49 167.6 4.7 8e-49 166.1 4.7 1.8 1 0 0 1 1 1 1 Striatin family WD40 PF00400.30 NM_001083893.1_1 - 5.1e-33 112.4 13.2 6.2e-08 33.1 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001083893.1_1 - 2.5e-06 27.5 0.1 0.19 11.9 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_001083893.1_1 - 0.00075 18.1 0.2 1.1 7.7 0.1 2.9 4 0 0 4 4 4 2 Nucleoporin Nup120/160 DUF4482 PF14818.4 NM_001083893.1_1 - 0.38 11.5 5.9 0.17 12.6 2.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) Pkinase PF00069.23 NM_016276.3_1 - 1.2e-67 227.9 0.0 1.5e-67 227.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_016276.3_1 - 1.4e-33 116.1 0.0 1.9e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_016276.3_1 - 2.2e-05 23.8 0.0 3.8e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 NM_016276.3_1 - 0.00025 21.6 0.1 0.00048 20.6 0.1 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.12 NM_016276.3_1 - 0.0055 15.9 0.0 0.0089 15.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 NM_016276.3_1 - 0.069 12.6 0.0 2 7.9 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Ets PF00178.20 NM_001308402.1_1 - 5.9e-32 109.9 1.1 8.6e-32 109.3 1.1 1.2 1 0 0 1 1 1 1 Ets-domain HSF_DNA-bind PF00447.15 NM_001308402.1_1 - 0.12 12.9 0.2 0.19 12.2 0.2 1.2 1 0 0 1 1 1 0 HSF-type DNA-binding PARP PF00644.18 NM_001308321.1_3 - 2e-26 92.8 1.2 7.1e-26 91.0 1.2 1.8 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Macro PF01661.19 NM_001308321.1_3 - 3.8e-10 39.7 0.0 9.1e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 Macro domain DUF3704 PF12488.6 NM_001308321.1_3 - 1.5 8.4 7.0 0.27 10.8 2.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3704) Rab5ip PF07019.10 NM_199483.2_3 - 1.4e-06 28.7 0.2 2.5e-06 27.9 0.2 1.4 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) PAS_11 PF14598.4 NM_002518.3_2 - 6.7e-22 77.6 0.0 4.2e-20 71.8 0.0 2.6 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.10 NM_002518.3_2 - 4.9e-17 61.9 0.1 9.1e-15 54.6 0.1 2.5 2 0 0 2 2 2 1 PAS fold PAS PF00989.23 NM_002518.3_2 - 2.6e-14 53.0 0.0 4.2e-11 42.7 0.0 2.6 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 NM_002518.3_2 - 9.7e-08 31.7 0.4 9.7e-08 31.7 0.4 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 NM_002518.3_2 - 0.0015 18.6 0.0 0.0038 17.3 0.0 1.7 1 0 0 1 1 1 1 PAS domain DehI PF10778.7 NM_002518.3_2 - 0.33 10.9 3.6 2.9 7.9 1.7 2.5 2 0 0 2 2 2 0 Halocarboxylic acid dehydrogenase DehI Robl_LC7 PF03259.15 NM_001319157.1_1 - 1.5e-22 79.0 0.0 2.5e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.3 NM_001319157.1_1 - 0.004 16.9 0.0 0.0068 16.2 0.0 1.3 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 Metallophos PF00149.26 NM_001322023.1_1 - 3.4e-22 79.8 0.1 4.4e-22 79.5 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 NM_001322023.1_1 - 2.4e-05 24.5 0.0 0.0039 17.3 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.8 NM_001322023.1_1 - 0.053 12.4 0.0 1.1 8.0 0.0 2.0 2 0 0 2 2 2 0 PhoD-like phosphatase RRM_5 PF13893.4 NM_031991.3_2 - 1.8e-62 208.4 0.5 2e-43 146.9 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 NM_031991.3_2 - 7.6e-36 121.6 1.3 2.4e-10 40.0 0.0 4.9 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_031991.3_2 - 4.2e-10 39.2 0.2 0.049 13.4 0.0 4.3 4 0 0 4 4 4 3 Occluded RNA-recognition motif SPRY PF00622.26 NM_052817.2_1 - 1.1e-10 41.5 0.0 1.9e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 NM_052817.2_1 - 1.7e-08 34.3 1.0 1.7e-08 34.3 1.0 4.4 5 0 0 5 5 4 2 B-box zinc finger fn3 PF00041.19 NM_052817.2_1 - 4.1e-07 30.1 0.1 7.5e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_UBOX PF13445.4 NM_052817.2_1 - 1.6e-06 27.9 9.1 1.6e-06 27.9 9.1 3.3 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_052817.2_1 - 3.4e-06 26.7 6.4 3.4e-06 26.7 6.4 3.9 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_052817.2_1 - 7.3e-06 25.6 10.0 7.3e-06 25.6 10.0 3.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_052817.2_1 - 1.4e-05 24.7 5.5 1.4e-05 24.7 5.5 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_052817.2_1 - 1.6e-05 24.8 12.4 1.6e-05 24.8 12.4 3.9 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 NM_052817.2_1 - 3.3e-05 23.9 10.6 3.3e-05 23.9 10.6 3.8 3 0 0 3 3 2 1 Ring finger domain PRY PF13765.4 NM_052817.2_1 - 4.9e-05 22.7 0.0 0.00012 21.5 0.0 1.6 1 0 0 1 1 1 1 SPRY-associated domain zf-RING_5 PF14634.4 NM_052817.2_1 - 0.0027 17.5 8.2 0.0027 17.5 8.2 3.2 2 0 0 2 2 2 1 zinc-RING finger domain CEBP_ZZ PF16366.3 NM_052817.2_1 - 0.018 15.1 3.2 0.11 12.6 3.2 2.4 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain ERM PF00769.17 NM_181832.2_3 - 3.9e-63 213.4 38.3 3.9e-63 213.4 38.3 3.1 2 1 1 3 3 3 2 Ezrin/radixin/moesin family FERM_M PF00373.16 NM_181832.2_3 - 2.2e-26 92.4 0.9 2.2e-26 92.4 0.9 2.7 2 1 0 2 2 2 1 FERM central domain FERM_C PF09380.8 NM_181832.2_3 - 4.8e-24 84.4 0.0 1.6e-23 82.8 0.0 1.9 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_181832.2_3 - 1e-10 41.2 0.6 1e-10 41.2 0.6 2.1 2 0 0 2 2 2 1 FERM N-terminal domain CAF1 PF04857.18 NM_002582.3_3 - 7.1e-89 298.0 3.0 7.1e-89 298.0 3.0 1.6 2 0 0 2 2 2 1 CAF1 family ribonuclease RNA_bind PF08675.9 NM_002582.3_3 - 1.2e-33 114.8 0.1 2.2e-33 114.0 0.1 1.4 1 0 0 1 1 1 1 RNA binding domain R3H PF01424.20 NM_002582.3_3 - 6.3e-05 22.8 0.0 0.00015 21.6 0.0 1.7 1 0 0 1 1 1 1 R3H domain PRT_C PF08372.8 NM_002582.3_3 - 0.0075 15.9 2.2 0.016 14.8 2.2 1.5 1 0 0 1 1 1 1 Plant phosphoribosyltransferase C-terminal NCBP3 PF10309.7 NM_002582.3_3 - 0.019 14.6 0.1 0.049 13.4 0.1 1.7 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 RRM_1 PF00076.20 NM_002582.3_3 - 0.052 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) VIT PF08487.8 NM_002582.3_3 - 0.22 11.7 2.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Vault protein inter-alpha-trypsin domain 7tm_4 PF13853.4 NM_012363.1_1 - 8.1e-56 189.7 21.3 9.8e-56 189.4 21.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_012363.1_1 - 6.3e-26 91.1 28.0 2.8e-25 88.9 28.0 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ion_trans PF00520.29 NM_080705.3_1 - 1.4e-14 53.8 18.2 2.1e-14 53.2 18.2 1.3 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.5 NM_080705.3_1 - 3.9e-14 52.9 2.1 6.1e-07 29.8 1.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.28 NM_080705.3_1 - 1.2e-09 38.1 0.3 0.0025 18.0 0.1 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.4 NM_080705.3_1 - 9.6e-09 35.2 0.1 0.22 11.8 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_080705.3_1 - 3.3e-08 33.0 0.1 0.0081 16.5 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.4 NM_080705.3_1 - 3.6e-06 27.3 0.1 0.16 12.4 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) NACHT PF05729.10 NM_001282143.1_3 - 1.7e-20 73.4 0.0 4.5e-20 72.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain LRR_6 PF13516.4 NM_001282143.1_3 - 2.4e-08 33.2 9.6 0.098 12.6 0.8 6.5 7 0 0 7 7 7 3 Leucine Rich repeat AAA_22 PF13401.4 NM_001282143.1_3 - 0.019 15.1 0.0 0.69 10.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.4 NM_001282143.1_3 - 0.025 14.8 0.9 0.087 13.1 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain DUF815 PF05673.11 NM_001282143.1_3 - 0.04 12.9 0.0 0.071 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TsaE PF02367.15 NM_001282143.1_3 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DNA_pol_B_palm PF14792.4 NM_013274.3_1 - 1.1e-34 118.9 0.0 2.1e-34 118.0 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.4 NM_013274.3_1 - 1.7e-21 76.0 0.0 3.4e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.7 NM_013274.3_1 - 2.6e-21 75.1 0.1 2.2e-20 72.1 0.1 2.3 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.4 NM_013274.3_1 - 4.8e-18 65.2 0.1 1.1e-17 64.0 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.4 NM_013274.3_1 - 1.6e-05 25.3 0.1 0.11 13.0 0.0 3.5 3 0 0 3 3 3 2 Helix-hairpin-helix domain BRCT_2 PF16589.3 NM_013274.3_1 - 0.0018 18.5 0.0 0.0033 17.7 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain HHH PF00633.21 NM_013274.3_1 - 0.02 14.6 0.1 0.15 11.9 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif NTP_transf_2 PF01909.21 NM_013274.3_1 - 0.025 14.8 0.0 0.053 13.7 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain Cdd1 PF11731.6 NM_013274.3_1 - 0.041 14.0 0.0 13 6.0 0.0 2.6 2 0 0 2 2 2 0 Pathogenicity locus Ion_trans PF00520.29 NM_001256789.2_3 - 3.1e-250 825.5 74.1 1.1e-68 231.0 0.8 4.1 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 NM_001256789.2_3 - 4.7e-158 526.6 0.4 4.7e-158 526.6 0.4 2.3 3 0 0 3 3 3 1 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 NM_001256789.2_3 - 3.5e-35 119.5 0.0 8.7e-35 118.2 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 NM_001256789.2_3 - 9.6e-30 102.6 0.1 2.2e-29 101.4 0.1 1.6 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 NM_001256789.2_3 - 5.3e-09 35.1 36.2 1.7e-07 30.2 4.3 9.0 8 2 1 9 9 9 4 Polycystin cation channel RNA_pol_3_Rpc31 PF11705.6 NM_001256789.2_3 - 0.0019 18.3 0.4 0.0019 18.3 0.4 3.0 3 0 0 3 3 3 1 DNA-directed RNA polymerase III subunit Rpc31 DUF4834 PF16118.3 NM_001256789.2_3 - 0.0043 17.8 16.0 4.1 8.3 0.0 7.7 7 0 0 7 7 7 1 Domain of unknown function (DUF4834) HemY_N PF07219.11 NM_001256789.2_3 - 0.94 9.6 10.5 0.57 10.3 0.0 4.9 4 0 0 4 4 4 0 HemY protein N-terminus EphA2_TM PF14575.4 NM_001256789.2_3 - 3.7 8.3 7.8 6 7.6 0.1 4.5 5 0 0 5 5 5 0 Ephrin type-A receptor 2 transmembrane domain ERM PF00769.17 NM_001260494.1_3 - 6e-75 252.1 52.3 6e-75 252.1 52.3 2.3 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.8 NM_001260494.1_3 - 1.5e-27 95.7 0.0 4e-27 94.3 0.0 1.8 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 NM_001260494.1_3 - 2.6e-09 37.4 0.2 2.6e-09 37.4 0.2 3.0 3 1 0 3 3 3 1 FERM central domain RasGEF PF00617.17 NM_001164389.1_3 - 2e-51 174.5 0.4 3.9e-51 173.5 0.4 1.5 1 0 0 1 1 1 1 RasGEF domain PDZ PF00595.22 NM_001164389.1_3 - 1.9e-14 53.6 0.1 5.3e-14 52.2 0.1 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RasGEF_N PF00618.18 NM_001164389.1_3 - 1e-12 48.0 0.4 5e-11 42.6 0.4 2.9 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 NM_001164389.1_3 - 6.5e-12 45.8 0.0 1.7e-11 44.5 0.0 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain cNMP_binding PF00027.27 NM_001164389.1_3 - 1.2e-11 44.3 0.0 1.9e-07 30.9 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_2 PF13180.4 NM_001164389.1_3 - 0.0015 18.7 0.0 0.0039 17.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Scm3 PF10384.7 NM_001164389.1_3 - 0.97 9.1 0.0 0.97 9.1 0.0 2.6 2 0 0 2 2 2 0 Centromere protein Scm3 Pellino PF04710.12 NM_001243135.1_1 - 6.1e-185 614.6 0.0 7.9e-185 614.2 0.0 1.1 1 0 0 1 1 1 1 Pellino zf-C3HC4_3 PF13920.4 NM_001243135.1_1 - 2.4 8.0 15.6 0.78 9.5 0.7 3.2 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Interferon PF00143.17 NM_006900.3_1 - 8.4e-68 227.4 0.7 9.9e-68 227.2 0.7 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain ACC_central PF08326.10 NM_198839.2_2 - 3.7e-284 944.3 8.4 4.6e-284 944.0 8.4 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.20 NM_198839.2_2 - 3.3e-184 613.0 0.0 4.3e-184 612.7 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.15 NM_198839.2_2 - 4e-54 183.2 0.0 7.8e-54 182.2 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.20 NM_198839.2_2 - 4.6e-31 107.5 0.0 9.4e-31 106.5 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.17 NM_198839.2_2 - 2.2e-22 79.1 0.0 9.8e-22 77.0 0.0 2.2 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.20 NM_198839.2_2 - 5e-17 61.4 0.1 1.4e-16 60.0 0.1 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.4 NM_198839.2_2 - 6.8e-07 28.2 0.0 0.0059 15.2 0.0 2.9 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.11 NM_198839.2_2 - 9.4e-06 25.2 0.0 2.1e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.20 NM_198839.2_2 - 1.1e-05 25.0 0.0 2.1e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.12 NM_198839.2_2 - 6.9e-05 22.8 0.0 0.00016 21.7 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATF7IP_BD PF16788.3 NM_001286515.1_3 - 8.7e-64 215.7 8.7 8.7e-64 215.7 8.7 3.1 4 0 0 4 4 4 1 ATF-interacting protein binding domain Tissue_fac PF01108.15 NM_021258.3_3 - 1.6e-27 95.3 0.4 7.3e-27 93.2 0.0 2.3 3 0 0 3 3 3 1 Tissue factor Interfer-bind PF09294.8 NM_021258.3_3 - 0.00034 20.7 0.0 0.00083 19.5 0.0 1.7 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III zf-H2C2_2 PF13465.4 NM_001322069.1_2 - 2.6e-29 100.2 42.2 7.4e-08 32.4 0.6 6.7 6 0 0 6 6 6 5 Zinc-finger double domain SCAN PF02023.15 NM_001322069.1_2 - 1.4e-25 88.8 0.3 2.6e-25 87.9 0.3 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 NM_001322069.1_2 - 6.2e-17 60.9 44.3 3.8e-05 23.8 1.3 5.6 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001322069.1_2 - 3.5e-14 52.1 41.0 0.0017 18.9 1.9 6.0 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001322069.1_2 - 1.2e-05 24.9 39.9 0.026 14.4 0.5 6.2 5 2 0 5 5 5 3 C2H2-type zinc finger zf-met PF12874.5 NM_001322069.1_2 - 2.2e-05 24.6 38.1 0.0039 17.4 6.0 5.3 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_001322069.1_2 - 0.0057 16.3 11.9 0.15 11.7 0.1 3.9 3 0 0 3 3 3 1 zinc-finger C2H2-type BolA PF01722.16 NM_001322069.1_2 - 0.21 11.8 1.6 6.9 6.9 0.1 3.0 2 1 0 2 2 2 0 BolA-like protein Zn-ribbon_8 PF09723.8 NM_001322069.1_2 - 0.4 10.7 19.7 0.35 10.9 2.5 4.5 2 2 2 4 4 4 0 Zinc ribbon domain zf-AN1 PF01428.14 NM_001322069.1_2 - 2.6 8.1 24.6 3.4 7.8 2.0 5.4 4 1 1 5 5 5 0 AN1-like Zinc finger DFRP_C PF16543.3 NM_018471.2_1 - 1.4e-23 83.1 1.4 1.4e-23 83.1 1.4 3.9 4 1 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.22 NM_018471.2_1 - 2.4e-06 27.1 1.6 4.9e-06 26.2 0.9 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.3 NM_018471.2_1 - 1.3e-05 25.7 11.0 4e-05 24.1 3.2 3.1 1 1 1 2 2 2 2 Torus domain zf-CCCH_3 PF15663.3 NM_018471.2_1 - 0.0081 16.3 4.1 0.27 11.4 3.2 2.9 2 1 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.4 NM_018471.2_1 - 0.37 11.2 10.9 0.11 12.9 4.0 3.0 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger TM231 PF10149.7 NM_001077416.2_1 - 2e-102 342.5 0.1 2.6e-102 342.1 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 231 TM231 PF10149.7 NM_001077416.2_3 - 4.5e-14 52.3 0.1 6.2e-14 51.9 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 231 Carn_acyltransf PF00755.18 NM_001031847.2_3 - 4.5e-189 629.7 0.0 6e-189 629.3 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 NM_001031847.2_3 - 4.4e-28 96.9 0.1 8.9e-28 95.9 0.1 1.6 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus RPA_interact_N PF14766.4 NM_001160243.1_1 - 5.8e-17 61.0 5.8 1e-16 60.2 5.8 1.4 1 0 0 1 1 1 1 Replication protein A interacting N-terminal RPA_interact_C PF14768.4 NM_001160243.1_1 - 2.7e-16 59.8 3.5 2.7e-16 59.8 3.5 2.0 2 0 0 2 2 2 1 Replication protein A interacting C-terminal RPA_interact_M PF14767.4 NM_001160243.1_1 - 2e-12 47.4 11.6 3.2e-12 46.7 11.6 1.3 1 0 0 1 1 1 1 Replication protein A interacting middle Snurportin1 PF11538.6 NM_001160243.1_1 - 0.13 12.4 9.2 0.052 13.7 3.2 2.3 2 0 0 2 2 2 0 Snurportin1 ENOD40 PF08247.9 NM_014796.2_2 - 1 9.4 4.6 1.8 8.6 0.5 2.7 2 0 0 2 2 2 0 ENOD40 protein KRAP_IP3R_bind PF14722.4 NM_014796.2_3 - 1.5e-51 173.8 0.1 2.9e-51 172.9 0.1 1.4 1 0 0 1 1 1 1 Ki-ras-induced actin-interacting protein-IP3R-interacting domain Mito_fiss_reg PF05308.9 NM_014637.3_3 - 6.2e-83 278.5 2.0 8.3e-83 278.1 2.0 1.1 1 0 0 1 1 1 1 Mitochondrial fission regulator PRIMA1 PF16101.3 NM_014637.3_3 - 0.073 13.0 3.5 0.16 11.9 3.5 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mnd1 PF03962.13 NM_014637.3_3 - 0.087 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Mnd1 family FlxA PF14282.4 NM_014637.3_3 - 0.5 10.3 5.0 0.87 9.5 5.0 1.3 1 0 0 1 1 1 0 FlxA-like protein Ephrin_lbd PF01404.17 NM_001288630.1_2 - 2.5e-71 239.3 0.1 3.6e-71 238.8 0.1 1.2 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain EGF_2 PF07974.11 NM_001288630.1_2 - 0.036 14.3 2.9 0.081 13.2 1.0 2.6 2 0 0 2 2 2 0 EGF-like domain EGF_MSP1_1 PF12946.5 NM_001288630.1_2 - 0.091 12.7 1.7 0.21 11.5 1.7 1.6 1 0 0 1 1 1 0 MSP1 EGF domain 1 Sulfotransfer_1 PF00685.25 NM_024533.4_1 - 1.3e-20 73.8 0.0 1.9e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_024533.4_1 - 6.4e-13 49.5 0.0 7.8e-12 45.9 0.0 2.2 1 1 0 1 1 1 1 Sulfotransferase family Glycos_transf_2 PF00535.24 NM_020474.3_2 - 1.1e-37 129.4 0.0 1.6e-37 128.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 NM_020474.3_2 - 1.7e-29 102.5 4.4 2.6e-29 101.9 4.4 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.4 NM_020474.3_2 - 5.2e-08 32.9 0.0 7.5e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.4 NM_020474.3_2 - 5.2e-05 23.8 0.2 0.011 16.4 0.1 2.7 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Glyco_transf_7C PF02709.12 NM_020474.3_2 - 5.5e-05 22.6 0.1 0.00011 21.6 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Pkinase PF00069.23 NM_001799.3_2 - 1.9e-74 250.3 0.0 2.2e-74 250.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001799.3_2 - 5.2e-32 111.0 0.0 6.9e-32 110.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001799.3_2 - 4.4e-06 26.1 0.2 0.0034 16.6 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Seadorna_VP7 PF07387.9 NM_001799.3_2 - 0.0003 19.8 0.0 0.003 16.5 0.0 2.0 2 0 0 2 2 2 1 Seadornavirus VP7 APH PF01636.21 NM_001799.3_2 - 0.013 15.3 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family PfkB PF00294.22 NM_001202449.1_1 - 3.2e-74 249.8 0.1 4.1e-74 249.5 0.1 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.10 NM_001202449.1_1 - 0.083 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase Tetraspannin PF00335.18 NM_001278741.1_1 - 5.3e-45 153.7 6.9 7.9e-45 153.1 6.9 1.2 1 0 0 1 1 1 1 Tetraspanin family 4HB_MCP_1 PF12729.5 NM_001278741.1_1 - 0.054 12.9 0.2 0.1 12.0 0.0 1.4 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Fibrinogen_C PF00147.16 NM_001199859.2_3 - 2.3e-69 233.4 5.8 3.4e-69 232.9 5.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4239 PF14023.4 NM_001199859.2_3 - 1.3 8.6 7.7 0.83 9.2 5.8 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) Pkinase_Tyr PF07714.15 NM_001321855.1_3 - 1.3e-148 493.2 0.1 6.6e-87 291.0 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.23 NM_001321855.1_3 - 2e-71 240.3 1.3 2.8e-45 154.6 0.0 2.8 3 0 0 3 3 3 2 Protein kinase domain Kinase-like PF14531.4 NM_001321855.1_3 - 0.0052 16.0 0.0 1.8 7.7 0.0 3.1 2 1 0 2 2 2 2 Kinase-like SH2 PF00017.22 NM_001321855.1_3 - 0.007 16.3 0.0 0.022 14.7 0.0 1.9 1 0 0 1 1 1 1 SH2 domain FERM_M PF00373.16 NM_001321855.1_3 - 0.042 14.1 0.1 0.12 12.6 0.1 1.9 1 0 0 1 1 1 0 FERM central domain DSPc PF00782.18 NM_175732.2_2 - 2.5e-15 56.3 0.1 3.7e-15 55.8 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DSPn PF14671.4 NM_175732.2_2 - 0.0083 16.4 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half Y_phosphatase PF00102.25 NM_175732.2_2 - 0.063 12.7 1.1 0.068 12.6 0.1 1.5 2 0 0 2 2 2 0 Protein-tyrosine phosphatase Hormone_recep PF00104.28 NM_178849.2_1 - 3.6e-40 137.6 0.0 5.7e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_178849.2_1 - 2.4e-29 101.4 18.4 4.4e-29 100.6 18.4 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Ribosomal_L44 PF00935.17 NM_021029.5_2 - 1.5e-39 134.2 10.1 2.8e-39 133.3 10.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L44 NOB1_Zn_bind PF08772.9 NM_021029.5_2 - 0.01 15.8 0.4 0.025 14.6 0.4 1.6 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like SOCS_box PF07525.14 NM_080868.2_3 - 2e-09 37.5 2.2 4e-09 36.5 2.2 1.5 1 0 0 1 1 1 1 SOCS box Ank_2 PF12796.5 NM_080868.2_3 - 0.00017 21.9 0.0 0.00085 19.7 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_080868.2_3 - 0.0028 18.1 0.0 0.016 15.6 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (many copies) HTH_Mga PF08280.9 NM_080868.2_3 - 0.0097 15.8 0.1 0.063 13.2 0.1 2.3 1 1 1 2 2 2 1 M protein trans-acting positive regulator (MGA) HTH domain Ank_3 PF13606.4 NM_080868.2_3 - 0.048 14.1 0.0 14 6.5 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat Asp-B-Hydro_N PF05279.9 NM_001256020.1_1 - 7.3e-08 32.6 38.9 2.2e-07 31.0 38.9 1.7 1 1 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region Borrelia_P83 PF05262.9 NM_001256020.1_1 - 0.87 7.9 34.0 1.2 7.4 34.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein GrpE PF01025.17 NM_025196.3_2 - 1.4e-42 145.1 1.4 1.9e-42 144.6 1.4 1.1 1 0 0 1 1 1 1 GrpE Aldo_ket_red PF00248.19 NM_005989.3_1 - 3.9e-45 154.1 0.0 5.7e-45 153.6 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Mg_trans_NIPA PF05653.12 NM_024759.2_2 - 1.3e-110 369.0 26.0 1.7e-110 368.6 26.0 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA DUF4131 PF13567.4 NM_024759.2_2 - 2.5 7.6 7.8 14 5.2 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Pkinase_Tyr PF07714.15 NM_013994.2_1 - 3.9e-81 272.0 0.0 4.9e-81 271.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_013994.2_1 - 1.3e-36 126.2 0.0 1.7e-35 122.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 NM_013994.2_1 - 4e-20 72.1 0.0 6.2e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Lamprin PF06403.9 NM_013994.2_1 - 0.033 14.0 0.5 0.073 12.9 0.5 1.5 1 0 0 1 1 1 0 Lamprin Kinase-like PF14531.4 NM_013994.2_1 - 0.075 12.2 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Methyltransf_23 PF13489.4 NM_023933.2_2 - 0.015 15.1 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.11 NM_023933.2_2 - 0.21 10.8 0.0 0.29 10.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) P53 PF00870.16 NM_001204188.1_3 - 2.8e-112 372.9 0.2 4.6e-112 372.2 0.2 1.3 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 NM_001204188.1_3 - 1.2e-18 66.0 0.5 2.4e-18 65.0 0.5 1.4 1 0 0 1 1 1 1 P53 tetramerisation motif SAM_2 PF07647.15 NM_001204188.1_3 - 3.8e-07 30.0 0.0 8.5e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_001204188.1_3 - 0.012 15.9 0.0 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) JAKMIP_CC3 PF16034.3 NM_001198905.1_1 - 0.023 14.5 7.6 0.05 13.4 7.6 1.5 1 0 0 1 1 1 0 JAKMIP CC3 domain CtnDOT_TraJ PF07863.9 NM_001198905.1_1 - 0.036 14.6 0.2 0.071 13.6 0.2 1.4 1 0 0 1 1 1 0 Homologues of TraJ from Bacteroides conjugative transposon UDPGT PF00201.16 NM_001322113.1_2 - 7.9e-117 390.9 0.0 1e-116 390.6 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 NM_001322113.1_2 - 8.7e-07 28.9 0.0 1.5e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Imm39 PF15568.4 NM_001322113.1_2 - 0.16 11.9 0.1 0.32 11.0 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 39 Peptidase_C13 PF01650.16 NM_005606.6_1 - 3e-115 384.0 2.8 4e-115 383.6 2.8 1.1 1 0 0 1 1 1 1 Peptidase C13 family RNase_T PF00929.22 NM_153332.3_3 - 8.2e-29 101.1 0.0 1.2e-28 100.6 0.0 1.2 1 0 0 1 1 1 1 Exonuclease SAP PF02037.25 NM_153332.3_3 - 1e-06 28.2 0.9 1.7e-06 27.5 0.9 1.4 1 0 0 1 1 1 1 SAP domain Adaptin_N PF01602.18 NM_130787.2_2 - 2.1e-148 495.0 3.1 2.5e-148 494.8 3.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.14 NM_130787.2_2 - 1.7e-44 150.5 0.0 3.3e-44 149.5 0.0 1.5 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.18 NM_130787.2_2 - 3.9e-20 72.1 0.1 7.2e-20 71.2 0.1 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.5 NM_130787.2_2 - 1.2e-07 31.8 0.6 1.3e-05 25.1 0.0 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 NM_130787.2_2 - 4.4e-06 26.9 1.7 0.012 15.8 0.2 4.3 3 1 0 4 4 4 1 HEAT repeats RIX1 PF08167.10 NM_130787.2_2 - 0.00041 20.0 1.6 0.013 15.1 0.1 3.2 2 1 0 3 3 3 1 rRNA processing/ribosome biogenesis HEAT PF02985.20 NM_130787.2_2 - 0.013 15.5 4.0 48 4.5 0.0 4.7 4 0 0 4 4 4 0 HEAT repeat Dymeclin PF09742.7 NM_130787.2_2 - 0.083 11.2 1.2 0.13 10.6 1.2 1.2 1 0 0 1 1 1 0 Dyggve-Melchior-Clausen syndrome protein TIP120 PF08623.8 NM_130787.2_2 - 0.36 10.5 1.7 11 5.6 0.2 2.4 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) IFRD PF05004.11 NM_130787.2_2 - 0.8 8.6 3.7 0.62 9.0 1.1 2.1 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) EGF_CA PF07645.13 NM_153214.2_2 - 7.6e-17 61.1 44.2 3.6e-10 39.8 7.0 5.1 5 0 0 5 5 5 3 Calcium-binding EGF domain cEGF PF12662.5 NM_153214.2_2 - 1.6e-11 43.7 8.9 7.3e-09 35.3 3.0 6.6 7 0 0 7 7 7 2 Complement Clr-like EGF-like EGF PF00008.25 NM_153214.2_2 - 5.4e-11 42.5 22.2 9.6e-10 38.5 10.4 5.9 5 0 0 5 5 5 2 EGF-like domain Sushi PF00084.18 NM_153214.2_2 - 1.2e-10 41.7 5.7 8.8e-10 38.9 0.5 3.0 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) hEGF PF12661.5 NM_153214.2_2 - 1.6e-08 34.8 39.0 3e-06 27.6 8.3 6.2 5 0 0 5 5 5 3 Human growth factor-like EGF FXa_inhibition PF14670.4 NM_153214.2_2 - 1.5e-07 31.4 5.2 1.5e-07 31.4 5.2 5.4 4 0 0 4 4 4 2 Coagulation Factor Xa inhibitory site EGF_2 PF07974.11 NM_153214.2_2 - 0.004 17.4 12.5 0.004 17.4 12.5 5.3 5 0 0 5 5 5 1 EGF-like domain EGF_3 PF12947.5 NM_153214.2_2 - 0.44 10.7 36.6 0.094 12.8 3.2 5.5 6 0 0 6 6 6 0 EGF domain MCLC PF05934.9 NM_001048210.2_3 - 0 1175.2 0.0 0 1174.9 0.0 1.1 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) SPRY PF00622.26 NM_001281805.1_1 - 2.1e-08 34.2 0.0 4.1e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 SPRY domain fn3 PF00041.19 NM_001281805.1_1 - 1.8e-06 28.1 1.5 0.0013 18.9 0.1 2.4 1 1 1 2 2 2 2 Fibronectin type III domain PRY PF13765.4 NM_001281805.1_1 - 2.7e-05 23.6 0.1 6.6e-05 22.3 0.1 1.7 1 0 0 1 1 1 1 SPRY-associated domain Apolipoprotein PF01442.16 NM_001281805.1_1 - 0.052 13.3 2.7 0.086 12.6 2.7 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Fumerase_C PF05683.10 NM_001281805.1_1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Fumarase C-terminus DUF5082 PF16888.3 NM_001281805.1_1 - 0.18 12.0 4.1 0.52 10.5 4.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) IZUMO PF15005.4 NM_001281805.1_1 - 0.51 10.7 6.0 0.15 12.5 1.4 2.1 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated DUF3552 PF12072.6 NM_001281805.1_1 - 1.1 8.5 10.0 1.7 7.9 10.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) OmpH PF03938.12 NM_001281805.1_1 - 2.5 8.0 7.1 5.6 6.8 7.1 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Jiraiya PF15038.4 NM_001281805.1_3 - 0.12 11.7 0.7 0.2 10.9 0.7 1.2 1 0 0 1 1 1 0 Jiraiya DUF4371 PF14291.4 NM_024772.4_1 - 3.5e-38 131.5 4.2 7.1e-38 130.5 4.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) zf-FCS PF06467.12 NM_024772.4_1 - 1.6e-23 82.3 36.4 2.7e-08 33.5 4.8 6.4 5 0 0 5 5 5 5 MYM-type Zinc finger with FCS sequence motif Dimer_Tnp_hAT PF05699.12 NM_024772.4_1 - 9.5e-17 60.4 1.6 1.8e-16 59.5 0.0 2.4 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Pro_isomerase PF00160.19 NM_024772.4_1 - 0.047 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RA PF00788.21 NM_003475.3_3 - 5e-13 49.4 0.0 9.9e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Stathmin PF00836.17 NM_005563.3_3 - 2.2e-59 199.2 28.5 2.7e-59 198.9 28.5 1.1 1 0 0 1 1 1 1 Stathmin family Ribonuc_2-5A PF06479.10 NM_005563.3_3 - 0.5 10.4 7.1 0.92 9.6 7.1 1.4 1 0 0 1 1 1 0 Ribonuclease 2-5A Exonuc_VII_L PF02601.13 NM_005563.3_3 - 1.6 8.1 9.0 2.2 7.6 9.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sema PF01403.17 NM_001198999.1_2 - 3.1e-131 437.9 0.0 6.8e-131 436.8 0.0 1.5 1 0 0 1 1 1 1 Sema domain PRT_C PF08372.8 NM_001198999.1_2 - 0.3 10.7 1.8 0.78 9.4 1.8 1.7 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal DUF2369 PF10179.7 NM_024574.3_3 - 5e-35 119.7 1.0 2.3e-29 101.6 0.3 3.0 3 0 0 3 3 3 2 Uncharacterised conserved protein (DUF2369) fn3 PF00041.19 NM_024574.3_3 - 6.6e-08 32.7 0.1 0.033 14.4 0.0 3.7 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_024574.3_3 - 1.1e-05 25.7 0.3 0.23 11.9 0.0 2.6 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain PI-PLC-X PF00388.17 NM_182734.2_1 - 1.4e-58 196.5 0.2 5e-58 194.7 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PLC-beta_C PF08703.8 NM_182734.2_1 - 2.2e-47 161.2 40.3 2.2e-47 161.2 40.3 2.5 2 0 0 2 2 2 1 PLC-beta C terminal PI-PLC-Y PF00387.17 NM_182734.2_1 - 3.7e-40 136.7 1.7 3.7e-40 136.7 1.7 2.7 3 0 0 3 3 3 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.9 NM_182734.2_1 - 3.3e-10 40.2 0.0 3.3e-10 40.2 0.0 2.3 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like DUF1154 PF06631.9 NM_182734.2_1 - 1.9e-06 27.6 10.9 1.9e-06 27.6 10.9 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF1154) PLC-beta_C PF08703.8 NM_182734.2_2 - 5.5e-05 23.1 0.2 9.3e-05 22.4 0.2 1.3 1 0 0 1 1 1 1 PLC-beta C terminal PfUIS3 PF11567.6 NM_182734.2_2 - 0.056 13.7 0.3 0.1 12.8 0.3 1.3 1 0 0 1 1 1 0 Plasmodium falciparum UIS3 membrane protein Septin PF00735.16 NM_001113494.1_1 - 6.2e-110 366.7 2.0 7.9e-110 366.4 2.0 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 NM_001113494.1_1 - 9.2e-09 35.3 0.0 1.6e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_001113494.1_1 - 7.4e-06 25.8 0.3 2e-05 24.4 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AIG1 PF04548.14 NM_001113494.1_1 - 0.00016 20.9 0.1 0.00025 20.3 0.1 1.2 1 0 0 1 1 1 1 AIG1 family Roc PF08477.11 NM_001113494.1_1 - 0.00058 20.0 0.1 0.00099 19.2 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.25 NM_001113494.1_1 - 0.00063 19.2 1.0 0.002 17.5 0.2 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.21 NM_001113494.1_1 - 0.001 19.0 1.7 0.038 13.9 0.7 2.3 1 1 1 2 2 2 1 Dynamin family Ras PF00071.20 NM_001113494.1_1 - 0.0016 17.9 0.0 0.003 17.1 0.0 1.4 1 0 0 1 1 1 1 Ras family FtsK_SpoIIIE PF01580.16 NM_001113494.1_1 - 0.0051 16.1 0.0 0.009 15.3 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.4 NM_001113494.1_1 - 0.0064 16.7 0.0 0.016 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.25 NM_001113494.1_1 - 0.0092 16.4 0.0 0.027 14.9 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.4 NM_001113494.1_1 - 0.011 15.8 0.0 0.044 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.18 NM_001113494.1_1 - 0.04 12.9 0.8 0.081 11.9 0.8 1.4 1 1 0 1 1 1 0 G-protein alpha subunit IIGP PF05049.11 NM_001113494.1_1 - 0.06 12.3 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.4 NM_001113494.1_1 - 0.097 12.3 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.4 NM_001113494.1_1 - 0.11 12.0 0.4 0.21 11.1 0.0 1.6 2 0 0 2 2 1 0 AAA domain NB-ARC PF00931.20 NM_001113494.1_1 - 0.16 10.8 0.1 0.23 10.3 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain Prokineticin PF06607.9 NM_032414.2_1 - 3.6e-48 161.7 7.5 6.5e-48 160.9 7.5 1.4 1 0 0 1 1 1 1 Prokineticin zf-H2C2_2 PF13465.4 NM_001136273.1_1 - 3.4e-58 191.5 35.1 6.1e-09 35.8 0.1 8.8 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001136273.1_1 - 7.2e-49 161.5 36.5 1.7e-07 31.1 0.2 8.4 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001136273.1_1 - 3.8e-31 104.9 39.4 0.00075 20.0 0.3 8.4 8 0 0 8 8 8 8 C2H2-type zinc finger KRAB PF01352.25 NM_001136273.1_1 - 2.6e-21 74.9 0.2 4e-21 74.3 0.2 1.3 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001136273.1_1 - 1.1e-18 66.6 36.6 6.4e-05 22.7 0.1 8.3 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001136273.1_1 - 1.9e-14 53.4 11.3 0.092 13.0 0.0 7.9 8 0 0 8 8 8 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001136273.1_1 - 2.6e-12 46.5 25.5 0.00024 21.0 0.2 5.6 3 2 3 6 6 6 5 Zinc ribbon domain zf-LYAR PF08790.9 NM_001136273.1_1 - 1.8e-06 27.6 16.3 7.5 6.4 0.1 8.0 8 0 0 8 8 8 0 LYAR-type C2HC zinc finger XPA_N PF01286.16 NM_001136273.1_1 - 2.2e-06 27.5 21.9 12 5.9 0.1 8.0 8 0 0 8 8 8 0 XPA protein N-terminal zf-C2H2_8 PF15909.3 NM_001136273.1_1 - 4.5e-06 26.8 19.1 0.04 14.1 2.0 4.4 1 1 3 4 4 4 2 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.3 NM_001136273.1_1 - 1.8e-05 25.3 16.4 0.75 10.4 0.3 4.6 1 1 4 5 5 5 4 zinc-ribbon family DZR PF12773.5 NM_001136273.1_1 - 2.9e-05 23.9 26.3 0.69 9.9 8.3 4.7 1 1 2 3 3 3 1 Double zinc ribbon zf-Di19 PF05605.10 NM_001136273.1_1 - 0.0003 20.9 20.4 0.023 14.8 1.4 4.8 1 1 6 7 7 7 3 Drought induced 19 protein (Di19), zinc-binding CpXC PF14353.4 NM_001136273.1_1 - 0.0039 17.1 20.4 3.1 7.7 0.6 7.2 2 2 4 6 6 6 1 CpXC protein C1_4 PF07975.10 NM_001136273.1_1 - 0.012 15.7 22.5 2.2 8.5 0.5 6.0 1 1 6 7 7 7 0 TFIIH C1-like domain MRP-S23 PF10484.7 NM_001136273.1_1 - 0.012 15.7 0.0 38 4.4 0.0 4.3 5 1 1 6 6 4 0 Mitochondrial ribosomal protein S23 HypA PF01155.17 NM_001136273.1_1 - 0.016 15.0 18.9 1 9.3 0.5 4.3 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA BolA PF01722.16 NM_001136273.1_1 - 0.023 14.8 3.6 3.5 7.8 1.3 4.0 3 1 0 3 3 3 0 BolA-like protein GAGA PF09237.9 NM_001136273.1_1 - 0.03 14.0 14.1 0.64 9.7 0.1 4.6 1 1 2 5 5 5 0 GAGA factor FYDLN_acid PF09538.8 NM_001136273.1_1 - 0.031 14.8 15.9 8.3 7.0 0.3 6.4 2 2 4 6 6 6 0 Protein of unknown function (FYDLN_acid) RNA_POL_M_15KD PF02150.14 NM_001136273.1_1 - 0.048 13.4 17.9 8.5 6.2 0.0 7.1 5 2 2 7 7 7 0 RNA polymerases M/15 Kd subunit zf-BED PF02892.13 NM_001136273.1_1 - 0.074 13.0 20.3 1.4 8.9 0.1 5.9 3 1 3 6 6 6 0 BED zinc finger zf-met PF12874.5 NM_001136273.1_1 - 0.078 13.3 29.2 1.6 9.1 0.3 7.9 8 0 0 8 8 8 0 Zinc-finger of C2H2 type ADK_lid PF05191.12 NM_001136273.1_1 - 0.086 12.7 17.0 0.34 10.8 1.0 4.8 4 2 0 4 4 4 0 Adenylate kinase, active site lid DUF3268 PF11672.6 NM_001136273.1_1 - 0.094 12.9 16.6 2.4 8.4 0.6 4.3 2 2 2 5 5 5 0 zinc-finger-containing domain DUF3797 PF12677.5 NM_001136273.1_1 - 0.096 12.4 4.8 13 5.6 0.1 4.1 4 0 0 4 4 3 0 Domain of unknown function (DUF3797) zf-AN1 PF01428.14 NM_001136273.1_1 - 0.11 12.6 26.7 17 5.6 0.1 7.9 8 0 0 8 8 8 0 AN1-like Zinc finger C1_1 PF00130.20 NM_001136273.1_1 - 0.16 11.8 21.4 4.5 7.1 0.7 6.2 1 1 7 8 8 8 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DNA_ligase_ZBD PF03119.14 NM_001136273.1_1 - 0.24 11.4 3.8 17 5.4 0.1 3.7 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain zinc-ribbons_6 PF07191.10 NM_001136273.1_1 - 0.44 10.4 23.7 5.8 6.8 1.3 5.2 1 1 1 3 3 3 0 zinc-ribbons zf-UBP PF02148.17 NM_001136273.1_1 - 0.89 9.8 23.3 26 5.1 0.6 5.7 1 1 2 3 3 2 0 Zn-finger in ubiquitin-hydrolases and other protein Zn_ribbon_recom PF13408.4 NM_001136273.1_1 - 0.95 9.9 28.2 79 3.7 4.8 6.6 2 2 3 5 5 5 0 Recombinase zinc beta ribbon domain zf-trcl PF13451.4 NM_001136273.1_1 - 1.6 8.6 23.5 26 4.6 0.1 7.5 8 0 0 8 8 8 0 Probable zinc-ribbon domain PknG_rubred PF16919.3 NM_001136273.1_1 - 3 7.8 24.4 0.55 10.2 0.6 4.6 1 1 3 5 5 5 0 Protein kinase G rubredoxin domain IBR PF01485.19 NM_001136273.1_1 - 4.4 7.5 22.3 2.3e+02 2.0 6.6 4.6 1 1 0 2 2 2 0 IBR domain, a half RING-finger domain LIM PF00412.20 NM_001136273.1_1 - 5 7.3 22.1 19 5.5 0.6 5.8 1 1 5 7 7 6 0 LIM domain YhfH PF14149.4 NM_001136273.1_1 - 5.6 6.9 20.4 32 4.5 0.0 6.5 7 0 0 7 7 6 0 YhfH-like protein zf-HIT PF04438.14 NM_001136273.1_1 - 6.5 6.6 27.7 13 5.6 0.1 6.7 7 0 0 7 7 7 0 HIT zinc finger FdhE PF04216.10 NM_001136273.1_1 - 6.6 6.4 13.5 2 8.0 0.7 3.5 1 1 3 4 4 4 0 Protein involved in formate dehydrogenase formation TerY_C PF15616.4 NM_001136273.1_1 - 7.4 6.6 10.1 1.8 8.5 0.1 2.9 2 1 1 3 3 2 0 TerY-C metal binding domain PAP2 PF01569.19 NM_203453.3_2 - 2.2e-16 59.7 4.6 3.7e-16 59.0 4.6 1.3 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.4 NM_203453.3_2 - 0.00026 20.6 7.1 0.00076 19.1 7.1 1.8 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 NM_203453.3_2 - 0.02 15.2 3.1 0.043 14.2 1.3 2.3 2 0 0 2 2 2 0 PAP2 superfamily C-terminal UQ_con PF00179.24 NM_181801.3_2 - 1.1e-44 151.4 0.0 1.4e-44 151.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.11 NM_181801.3_2 - 0.0097 15.6 0.0 0.018 14.8 0.0 1.4 1 1 0 1 1 1 1 UEV domain RWD PF05773.20 NM_181801.3_2 - 0.029 14.5 0.0 0.042 14.0 0.0 1.3 1 0 0 1 1 1 0 RWD domain Pkinase_Tyr PF07714.15 NM_015850.3_1 - 7.3e-104 346.5 0.0 1.2e-103 345.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_015850.3_1 - 1.8e-45 155.3 0.0 2.7e-45 154.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 NM_015850.3_1 - 7.4e-37 125.2 0.0 1.5e-13 50.5 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_015850.3_1 - 5.6e-31 106.9 0.1 2.1e-11 44.1 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_015850.3_1 - 7.1e-28 96.5 0.1 1.4e-08 34.6 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_015850.3_1 - 2.7e-23 82.0 0.4 1.2e-09 38.3 0.1 4.1 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 NM_015850.3_1 - 2e-12 47.1 0.9 0.00049 20.1 0.0 5.2 4 2 0 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_015850.3_1 - 0.0013 18.6 0.1 0.76 9.8 0.0 3.5 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain zf-H2C2_2 PF13465.4 NM_001324167.1_1 - 5.7e-51 168.7 31.9 9.9e-10 38.3 0.4 7.6 7 0 0 7 7 7 7 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001324167.1_1 - 6.3e-42 139.6 39.6 1.6e-06 28.1 0.1 7.7 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001324167.1_1 - 1.1e-24 84.8 40.4 0.00094 19.7 0.2 7.6 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001324167.1_1 - 5.5e-17 61.2 30.1 0.013 15.3 0.2 7.7 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001324167.1_1 - 7.3e-10 38.8 14.1 0.029 14.5 0.1 7.0 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding C1_4 PF07975.10 NM_001324167.1_1 - 4.4e-08 33.1 18.4 0.012 15.7 0.6 4.9 3 1 2 5 5 5 3 TFIIH C1-like domain zf-C2H2_11 PF16622.3 NM_001324167.1_1 - 1.9e-06 27.4 30.2 0.058 13.0 0.1 6.5 7 0 0 7 7 7 4 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 NM_001324167.1_1 - 4e-06 26.7 33.4 0.028 14.4 3.6 5.9 1 1 6 7 7 7 6 Zinc ribbon domain DZR PF12773.5 NM_001324167.1_1 - 0.0001 22.1 25.6 0.7 9.8 1.3 4.5 1 1 3 4 4 4 3 Double zinc ribbon zf-C2HC_2 PF13913.4 NM_001324167.1_1 - 0.00016 21.3 29.0 0.11 12.3 0.2 6.9 7 0 0 7 7 7 3 zinc-finger of a C2HC-type C1_1 PF00130.20 NM_001324167.1_1 - 0.0006 19.5 33.6 0.0037 17.0 2.5 6.1 3 2 3 6 6 5 3 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-AN1 PF01428.14 NM_001324167.1_1 - 0.0006 19.8 26.1 3.8 7.6 0.2 7.4 7 0 0 7 7 7 1 AN1-like Zinc finger zf-met PF12874.5 NM_001324167.1_1 - 0.0011 19.2 33.4 0.023 15.0 0.2 6.7 7 0 0 7 7 6 3 Zinc-finger of C2H2 type ADK_lid PF05191.12 NM_001324167.1_1 - 0.0013 18.6 19.5 0.81 9.6 0.7 4.6 4 1 0 4 4 4 3 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 NM_001324167.1_1 - 0.0091 16.6 21.5 1.1 10.0 1.1 4.4 1 1 4 5 5 5 3 zinc-ribbon family CpXC PF14353.4 NM_001324167.1_1 - 0.02 14.8 20.8 6 6.8 1.2 6.5 1 1 6 7 7 7 0 CpXC protein DNA_RNApol_7kD PF03604.11 NM_001324167.1_1 - 0.053 13.1 24.5 3.1 7.4 0.2 7.3 7 0 0 7 7 7 0 DNA directed RNA polymerase, 7 kDa subunit SprT-like PF10263.7 NM_001324167.1_1 - 0.066 12.9 31.5 1.1 9.0 3.1 4.4 1 1 5 6 6 6 0 SprT-like family zf-LYAR PF08790.9 NM_001324167.1_1 - 0.12 12.2 24.7 13 5.6 0.5 7.2 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger DUF3268 PF11672.6 NM_001324167.1_1 - 0.24 11.6 20.4 0.54 10.5 0.7 4.1 1 1 0 4 4 4 0 zinc-finger-containing domain DUF2256 PF10013.7 NM_001324167.1_1 - 0.3 11.1 21.4 18 5.4 0.1 7.1 7 0 0 7 7 7 0 Uncharacterized protein conserved in bacteria (DUF2256) LIM PF00412.20 NM_001324167.1_1 - 0.31 11.1 27.4 7.1 6.8 2.8 6.2 2 2 3 5 5 5 0 LIM domain zinc-ribbons_6 PF07191.10 NM_001324167.1_1 - 0.47 10.3 29.6 1.9 8.4 2.6 5.2 1 1 3 4 4 4 0 zinc-ribbons HypA PF01155.17 NM_001324167.1_1 - 0.6 10.0 22.0 1.6 8.6 0.9 4.2 1 1 5 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA XPA_N PF01286.16 NM_001324167.1_1 - 1.2 9.1 27.1 7.8 6.5 0.5 6.7 7 0 0 7 7 7 0 XPA protein N-terminal YhfH PF14149.4 NM_001324167.1_1 - 4.3 7.3 25.2 15 5.5 0.2 6.0 6 0 0 6 6 6 0 YhfH-like protein GATA PF00320.25 NM_001324167.1_1 - 4.9 6.7 17.9 20 4.8 0.1 5.9 5 1 0 5 5 5 0 GATA zinc finger GATase PF00117.26 NM_001301237.1_3 - 1.3e-52 178.2 0.0 1.8e-52 177.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CTP_synth_N PF06418.12 NM_001301237.1_3 - 3.8e-50 170.5 0.0 5.3e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus Peptidase_C26 PF07722.11 NM_001301237.1_3 - 1.6e-08 34.5 0.0 2.7e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 Transket_pyr PF02779.22 NM_001301237.1_3 - 0.066 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain C2 PF00168.28 NM_001308157.1_1 - 6.4e-41 138.7 0.1 1.5e-20 73.2 0.0 2.3 2 0 0 2 2 2 2 C2 domain Troponin PF00992.18 NM_001276346.1_3 - 1.5e-23 83.4 38.7 3.9e-19 69.1 25.1 3.1 2 1 1 3 3 3 2 Troponin Prominin PF05478.9 NM_001276346.1_3 - 8.4 4.1 6.2 13 3.4 6.2 1.3 1 0 0 1 1 1 0 Prominin Apyrase PF06079.9 NM_138793.3_1 - 5.3e-131 436.0 0.1 6.5e-131 435.7 0.1 1.1 1 0 0 1 1 1 1 Apyrase NPIP PF06409.9 NM_001278507.1_1 - 0.021 13.9 5.9 0.046 12.8 5.9 1.5 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) Prismane PF03063.18 NM_001278507.1_1 - 1 7.8 5.7 2.2 6.7 5.7 1.4 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family DUF1664 PF07889.10 NM_001278507.1_1 - 5.7 6.8 20.1 1.4 8.8 3.5 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.19 NM_182898.3_1 - 1.1e-11 44.6 8.5 1.1e-11 44.6 8.5 1.9 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.13 NM_182898.3_1 - 3.8e-09 36.3 8.3 3.8e-09 36.3 8.3 2.5 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_182898.3_1 - 0.0011 19.4 5.1 0.0011 19.4 5.1 1.7 2 0 0 2 2 2 1 bZIP Maf transcription factor ZapB PF06005.10 NM_182898.3_1 - 0.025 14.9 2.7 0.068 13.5 2.7 1.7 1 0 0 1 1 1 0 Cell division protein ZapB TolA_bind_tri PF16331.3 NM_182898.3_1 - 0.074 13.0 3.1 0.16 12.0 3.1 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation GIT_CC PF16559.3 NM_182898.3_1 - 1.2 9.1 5.2 2.7 8.0 5.2 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor PAC1 PF16094.3 NM_203433.2_1 - 4.6e-111 370.4 4.7 3.6e-62 210.0 1.3 2.0 1 1 1 2 2 2 2 Proteasome assembly chaperone 4 CC PF04942.12 NM_203433.2_1 - 7.2 6.8 7.0 24 5.1 0.3 3.4 4 0 0 4 4 4 0 CC domain NDK PF00334.17 NM_003551.2_1 - 5.1e-36 123.5 0.0 7.1e-36 123.1 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Dpy-30 PF05186.11 NM_003551.2_1 - 1.1e-19 69.6 1.1 1.8e-19 69.0 1.1 1.3 1 0 0 1 1 1 1 Dpy-30 motif adh_short_C2 PF13561.4 NM_018441.5_1 - 7e-53 179.5 0.0 9e-53 179.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 NM_018441.5_1 - 4.7e-46 156.6 0.2 6.4e-46 156.2 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 NM_018441.5_1 - 1.7e-08 34.5 0.0 2.5e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.16 NM_018441.5_1 - 8.2e-05 22.7 0.0 0.00024 21.2 0.0 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.15 NM_018441.5_1 - 0.00038 20.9 0.1 0.00072 20.0 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.19 NM_018441.5_1 - 0.0021 17.4 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.13 NM_018441.5_1 - 0.0034 16.4 0.0 0.0054 15.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.3 NM_018441.5_1 - 0.042 13.1 0.0 0.063 12.5 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 2-Hacid_dh_C PF02826.17 NM_018441.5_1 - 0.046 12.9 0.0 0.07 12.3 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3Beta_HSD PF01073.17 NM_018441.5_1 - 0.056 12.3 0.0 0.076 11.8 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Oxysterol_BP PF01237.16 NM_145322.2_3 - 1.9e-132 441.5 0.3 3.2e-132 440.7 0.3 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.4 NM_145322.2_3 - 8.6e-12 45.0 0.3 1.6e-11 44.1 0.3 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 NM_145322.2_3 - 1e-07 32.3 3.7 2.3e-07 31.1 1.7 2.2 2 0 0 2 2 2 1 PH domain PH_11 PF15413.4 NM_145322.2_3 - 3.7 7.9 5.8 1e+02 3.2 5.8 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain TPR_1 PF00515.26 NM_001144766.2_2 - 1.4e-40 135.4 30.5 2.4e-06 27.0 0.0 9.0 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001144766.2_2 - 1.4e-38 127.7 23.6 5.8e-06 25.9 1.6 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat DnaJ PF00226.29 NM_001144766.2_2 - 6.7e-24 83.7 2.2 6.7e-24 83.7 2.2 2.4 2 0 0 2 2 2 1 DnaJ domain TPR_8 PF13181.4 NM_001144766.2_2 - 3.2e-22 76.7 20.3 0.00035 20.4 0.4 8.8 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001144766.2_2 - 1.9e-16 59.3 26.5 8.2e-07 28.5 4.0 8.0 6 1 2 8 8 8 5 TPR repeat TPR_16 PF13432.4 NM_001144766.2_2 - 2.3e-16 60.0 4.9 0.00069 20.1 0.0 5.7 4 2 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001144766.2_2 - 2.9e-16 59.6 13.2 0.0073 16.7 0.2 6.4 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001144766.2_2 - 5.3e-16 57.7 15.2 9.9e-05 22.3 0.1 8.5 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001144766.2_2 - 6.3e-16 58.3 19.4 1.8e-05 24.8 1.1 6.6 5 3 1 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001144766.2_2 - 5e-11 42.3 7.5 0.59 11.0 0.0 8.4 6 2 3 9 9 8 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001144766.2_2 - 1.5e-09 37.7 6.7 0.23 11.5 0.1 5.5 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001144766.2_2 - 2.5e-08 33.2 11.6 0.087 12.8 0.4 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001144766.2_2 - 1e-06 28.7 27.9 0.0049 16.9 0.2 6.0 1 1 5 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 NM_001144766.2_2 - 5.4e-06 26.6 17.8 0.14 12.7 0.8 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001144766.2_2 - 5.2e-05 22.9 17.6 0.6 9.9 0.4 6.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_4 PF07721.12 NM_001144766.2_2 - 0.0068 16.8 0.9 4.2 8.2 0.0 3.7 3 0 0 3 3 2 1 Tetratricopeptide repeat RPT PF13446.4 NM_001144766.2_2 - 0.056 13.2 0.0 0.27 11.0 0.0 2.2 1 0 0 1 1 1 0 A repeated domain in UCH-protein Alkyl_sulf_dimr PF14863.4 NM_001144766.2_2 - 0.18 12.1 9.6 17 5.8 0.1 4.5 4 1 1 5 5 5 0 Alkyl sulfatase dimerisation Sel1 PF08238.10 NM_001144766.2_2 - 0.38 11.4 5.5 3.3 8.4 0.5 4.0 3 0 0 3 3 3 0 Sel1 repeat RPN7 PF10602.7 NM_001144766.2_2 - 0.62 9.6 13.7 0.25 10.9 4.0 2.9 2 1 0 2 2 2 0 26S proteasome subunit RPN7 BTAD PF03704.15 NM_001144766.2_2 - 1 9.7 13.0 47 4.3 0.2 4.7 1 1 2 4 4 4 0 Bacterial transcriptional activator domain MIT PF04212.16 NM_001144766.2_2 - 1.6 8.8 27.1 0.46 10.5 1.2 6.0 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.7 NM_001144766.2_2 - 3.7 7.0 6.2 13 5.2 0.1 4.4 4 1 1 5 5 5 0 SHNi-TPR Vg_Tdu PF07545.12 NM_001320493.1_3 - 6.6e-19 67.2 0.2 1.3e-18 66.3 0.2 1.5 1 0 0 1 1 1 1 Vestigial/Tondu family BORA_N PF15280.4 NM_001286746.1_1 - 8e-71 238.2 1.4 2.3e-70 236.7 1.4 1.8 1 0 0 1 1 1 1 Protein aurora borealis N-terminus HMG14_17 PF01101.16 NM_006353.2_2 - 1.8e-27 96.0 23.0 2.4e-27 95.6 23.0 1.2 1 0 0 1 1 1 1 HMG14 and HMG17 CSD PF00313.20 NM_001242891.1_1 - 2e-82 270.9 17.8 3.4e-17 61.9 0.2 9.2 9 0 0 9 9 9 7 'Cold-shock' DNA-binding domain S1-like PF14444.4 NM_001242891.1_1 - 3.3e-14 52.6 17.5 0.08 12.9 0.0 8.1 8 0 0 8 8 8 6 S1-like SUZ-C PF12901.5 NM_001242891.1_1 - 2.3e-10 40.1 0.5 1e-09 38.0 0.0 2.2 2 0 0 2 2 2 1 SUZ-C motif CusF_Ec PF11604.6 NM_001242891.1_1 - 1.4e-07 31.2 10.1 0.15 11.9 0.0 7.6 8 0 0 8 8 8 2 Copper binding periplasmic protein CusF RsgA_N PF16745.3 NM_001242891.1_1 - 0.0006 19.3 5.8 6.6 6.4 0.0 6.1 6 0 0 6 6 6 1 RsgA N-terminal domain HasA PF06438.10 NM_001242891.1_1 - 0.021 14.3 0.0 0.12 11.8 0.1 2.1 2 0 0 2 2 2 0 Heme-binding protein A (HasA) DUF3857 PF12969.5 NM_001242891.1_1 - 0.058 13.3 0.1 7.5 6.5 0.0 3.3 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3857) Mg_trans_NIPA PF05653.12 NM_001322854.1_3 - 1.4e-71 240.9 21.7 1.9e-71 240.5 21.7 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA DUF1908 PF08926.9 NM_001324320.1_2 - 4.3e-142 472.2 1.5 1.7e-141 470.2 1.5 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1908) Pkinase PF00069.23 NM_001324320.1_2 - 6.5e-62 209.1 0.0 9.8e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001324320.1_2 - 3.3e-25 88.7 0.0 6.5e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.22 NM_001324320.1_2 - 7.8e-08 32.4 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001324320.1_2 - 1.1e-06 28.7 0.0 2.7e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain APH PF01636.21 NM_001324320.1_2 - 0.00064 19.6 1.2 0.069 12.9 0.0 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_001324320.1_2 - 0.0023 17.2 0.0 0.0067 15.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Tricorn_PDZ PF14685.4 NM_001324320.1_2 - 0.052 13.4 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain RIO1 PF01163.20 NM_001324320.1_2 - 0.088 12.3 0.1 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 RIO1 family AF-4 PF05110.11 NM_001169123.1_3 - 0 1325.3 57.8 0 1325.1 57.8 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Cobl PF09469.8 NM_001278461.1_1 - 3e-46 155.5 1.8 6.5e-46 154.4 0.7 2.1 2 0 0 2 2 2 1 Cordon-bleu ubiquitin-like domain RBD PF02196.13 NM_001278461.1_1 - 0.00018 21.4 0.2 0.072 13.1 0.0 2.5 2 0 0 2 2 2 2 Raf-like Ras-binding domain zf-piccolo PF05715.11 NM_014510.2_2 - 3.7e-57 190.2 32.6 2e-30 104.6 12.5 2.6 2 0 0 2 2 2 2 Piccolo Zn-finger C2 PF00168.28 NM_014510.2_2 - 1.8e-23 82.6 0.1 3.9e-23 81.6 0.1 1.6 1 0 0 1 1 1 1 C2 domain PDZ PF00595.22 NM_014510.2_2 - 1.1e-07 31.9 0.2 3.6e-07 30.3 0.2 1.9 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FYVE_2 PF02318.14 NM_014510.2_2 - 1.7e-05 24.8 12.6 0.00017 21.7 2.3 4.8 6 0 0 6 6 6 2 FYVE-type zinc finger IBR PF01485.19 NM_014510.2_2 - 5.2 7.2 14.1 8.2 6.6 3.7 2.7 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain CSD PF00313.20 NM_024674.5_2 - 1.9e-15 56.3 0.0 3.3e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCHC PF00098.21 NM_024674.5_2 - 3.7e-05 23.5 8.7 0.00037 20.3 3.0 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.4 NM_024674.5_2 - 2.4 7.8 9.3 3.4 7.3 1.6 2.5 2 0 0 2 2 2 0 Zinc knuckle UCH PF00443.27 NM_001256862.1_1 - 9.3e-48 162.8 1.9 6.1e-47 160.1 0.6 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001256862.1_1 - 3e-19 69.6 1.0 1e-16 61.3 0.0 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase HABP4_PAI-RBP1 PF04774.13 NM_001256862.1_1 - 5.1e-05 23.9 1.0 0.00011 22.9 1.0 1.5 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family Amidase PF01425.19 NM_018292.4_3 - 5.3e-127 424.4 0.0 3.3e-126 421.7 0.0 1.9 1 1 0 1 1 1 1 Amidase Kunitz_BPTI PF00014.21 NM_020398.3_1 - 1.9e-18 66.3 10.2 5.9e-18 64.7 10.2 1.9 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain WAP PF00095.19 NM_020398.3_1 - 6e-05 23.2 17.1 6e-05 23.2 17.1 3.0 4 0 0 4 4 4 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Guanylate_kin PF00625.19 NM_001142702.1_1 - 5.6e-65 218.3 0.1 7.8e-65 217.8 0.1 1.2 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.15 NM_001142702.1_1 - 1.8e-08 33.8 0.0 3.5e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001142702.1_1 - 7e-08 31.8 0.0 1.2e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001142702.1_1 - 0.0098 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Mito_carr PF00153.25 NM_001077241.2_3 - 2.8e-59 196.9 0.2 1.2e-20 73.0 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein LBP_BPI_CETP PF01273.23 NM_182658.2_1 - 8.1e-27 93.7 0.2 1.9e-26 92.5 0.2 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.15 NM_182658.2_1 - 2.4e-21 76.1 1.3 4.6e-21 75.2 1.3 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain 7tm_2 PF00002.22 NM_001309516.1_1 - 3.3e-87 291.7 15.3 4.6e-87 291.2 15.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_001309516.1_1 - 8e-16 58.0 3.3 8e-16 58.0 3.3 2.4 2 0 0 2 2 2 1 Hormone receptor domain NT5C PF06941.10 NM_001252377.1_2 - 3.5e-13 49.7 0.0 4.5e-12 46.1 0.0 1.9 1 1 1 2 2 2 2 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) zf-H2C2_2 PF13465.4 NM_005815.4_1 - 5.4e-126 405.8 180.7 7e-09 35.6 4.8 19.9 21 0 0 21 21 20 18 Zinc-finger double domain zf-C2H2 PF00096.24 NM_005815.4_1 - 5.5e-63 205.9 167.8 1.8e-05 24.8 0.1 19.4 19 0 0 19 19 19 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_005815.4_1 - 3.4e-50 164.2 161.7 0.00093 19.7 2.0 19.5 19 0 0 19 19 19 17 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_005815.4_1 - 2.4e-36 122.9 124.7 1.3e-06 28.0 3.5 18.3 17 0 0 17 17 17 17 C2H2-type zinc finger KRAB PF01352.25 NM_005815.4_1 - 1.3e-18 66.3 0.1 2.2e-18 65.5 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_11 PF16622.3 NM_005815.4_1 - 7.3e-12 44.7 85.9 0.0046 16.5 0.2 14.4 15 0 0 15 15 15 7 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 NM_005815.4_1 - 1.6e-10 40.8 97.7 0.015 15.3 4.1 13.7 6 2 12 18 18 17 11 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_005815.4_1 - 1.1e-09 38.2 117.9 0.095 12.9 1.8 18.9 20 0 0 20 20 19 7 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 NM_005815.4_1 - 1.4e-06 27.9 72.3 0.017 14.9 0.9 14.4 11 3 1 12 12 12 4 Probable zinc-ribbon domain Soc PF16855.3 NM_005815.4_1 - 0.00073 19.8 0.3 9.9 6.6 0.0 5.3 4 2 2 6 6 6 1 Small outer capsid protein XPA_N PF01286.16 NM_005815.4_1 - 0.0028 17.5 78.1 4.2 7.4 0.6 16.6 17 0 0 17 17 17 5 XPA protein N-terminal zf-met PF12874.5 NM_005815.4_1 - 0.18 12.1 0.1 0.18 12.1 0.1 13.6 15 0 0 15 15 15 0 Zinc-finger of C2H2 type Baculo_LEF-11 PF06385.10 NM_005815.4_2 - 0.013 15.8 0.4 0.83 10.1 0.0 3.6 5 0 0 5 5 5 0 Baculovirus LEF-11 protein RNA_pol_Rpb6 PF01192.20 NM_021974.4_3 - 7.5e-15 54.5 0.2 1.3e-14 53.7 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 Glyco_hydro_65m PF03632.13 NM_025092.4_2 - 6.6e-52 176.5 0.0 6.3e-45 153.5 0.2 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain DUF2152 PF10222.7 NM_025092.4_2 - 0.16 10.1 0.0 1.8 6.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2152) Sin3a_C PF16879.3 NM_015477.2_2 - 5e-100 334.8 9.8 5e-100 334.8 9.8 1.8 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein PAH PF02671.19 NM_015477.2_2 - 5.1e-49 164.1 5.3 1e-18 67.1 0.0 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.10 NM_015477.2_2 - 8.2e-42 141.1 0.2 1.7e-41 140.1 0.2 1.6 1 0 0 1 1 1 1 Sin3 family co-repressor TEA PF01285.16 NM_001256659.1_2 - 4.6e-28 98.4 0.0 1.3e-27 96.9 0.0 1.6 1 1 0 1 1 1 1 TEA/ATTS domain family BTB PF00651.29 NM_001304508.1_3 - 5.5e-12 45.8 0.1 8e-12 45.2 0.1 1.2 1 0 0 1 1 1 1 BTB/POZ domain Staufen_C PF16482.3 NM_001322930.1_1 - 2.7e-53 178.7 0.1 3e-50 168.9 0.0 3.7 4 0 0 4 4 4 1 Staufen C-terminal domain dsrm PF00035.24 NM_001322930.1_1 - 1.2e-33 115.4 0.5 8.7e-12 45.4 0.1 3.7 3 0 0 3 3 3 3 Double-stranded RNA binding motif DND1_DSRM PF14709.5 NM_001322930.1_1 - 0.00022 21.3 0.1 0.047 13.8 0.0 3.3 3 0 0 3 3 3 1 double strand RNA binding domain from DEAD END PROTEIN 1 Fibrinogen_C PF00147.16 NM_147203.2_3 - 2.9e-79 265.8 16.4 3.8e-79 265.4 16.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain SH2 PF00017.22 NM_005541.4_3 - 1.4e-15 56.9 0.0 3.2e-15 55.8 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Exo_endo_phos PF03372.21 NM_005541.4_3 - 2e-05 24.7 0.0 4e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DAGAT PF03982.11 NM_058165.2_1 - 1.2e-119 398.5 1.1 1.5e-119 398.2 1.1 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase HTH_OrfB_IS605 PF12323.6 NM_058165.2_1 - 0.16 11.3 1.9 0.68 9.3 0.8 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain PUF PF00806.17 NM_001020658.1_3 - 9.6e-69 223.3 9.5 9.4e-09 34.4 0.1 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.9 NM_001020658.1_3 - 0.1 12.8 0.7 8.2 6.6 0.1 3.4 2 1 1 3 3 3 0 CPL (NUC119) domain RRM_1 PF00076.20 NM_001172673.1_1 - 8.7e-31 105.4 0.0 1e-14 54.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001172673.1_1 - 0.018 15.0 0.0 0.73 9.9 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif RRM_1 PF00076.20 NM_001172673.1_2 - 2.5e-14 52.7 0.1 4.4e-14 51.9 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CHCH PF06747.11 NM_001318195.1_2 - 1.4e-09 37.7 2.8 1.4e-09 37.7 2.8 2.4 2 0 0 2 2 2 1 CHCH domain CX9C PF16860.3 NM_001318195.1_2 - 0.0028 17.5 2.3 0.0028 17.5 2.3 2.5 2 0 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.8 NM_001318195.1_2 - 0.049 13.5 1.2 0.049 13.5 1.2 2.3 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like Cdd1 PF11731.6 NM_001318195.1_2 - 0.21 11.7 2.2 11 6.3 0.2 2.2 1 1 1 2 2 2 0 Pathogenicity locus Pacs-1 PF10254.7 NM_001243127.2_3 - 5.4e-202 671.1 0.0 7.8e-202 670.6 0.0 1.2 1 0 0 1 1 1 1 PACS-1 cytosolic sorting protein Glyco_transf_22 PF03901.15 NM_001077691.1_2 - 1.5e-122 409.7 35.2 2.7e-122 408.9 35.2 1.4 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family EMI PF07546.11 NM_201446.2_2 - 5.5e-18 65.3 4.4 5.5e-18 65.3 4.4 2.1 2 1 0 2 2 2 1 EMI domain EGF_CA PF07645.13 NM_201446.2_2 - 2.7e-07 30.5 5.2 2.7e-07 30.5 5.2 3.2 3 0 0 3 3 3 1 Calcium-binding EGF domain FXa_inhibition PF14670.4 NM_201446.2_2 - 6.9e-07 29.3 7.0 6.9e-07 29.3 7.0 3.3 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site EGF_2 PF07974.11 NM_201446.2_2 - 4.6e-06 26.7 10.1 4.6e-06 26.7 10.1 3.6 3 0 0 3 3 3 1 EGF-like domain EGF PF00008.25 NM_201446.2_2 - 0.0014 18.7 9.5 0.0014 18.7 9.5 3.8 4 0 0 4 4 4 2 EGF-like domain hEGF PF12661.5 NM_201446.2_2 - 0.0075 16.8 8.4 0.0075 16.8 8.4 4.5 5 0 0 5 5 5 2 Human growth factor-like EGF cEGF PF12662.5 NM_201446.2_2 - 0.012 15.4 0.3 0.012 15.4 0.3 3.8 4 0 0 4 4 4 0 Complement Clr-like EGF-like SlyX PF04102.10 NM_201446.2_2 - 0.16 12.4 0.2 17 6.0 0.2 2.3 2 0 0 2 2 2 0 SlyX Trimer_CC PF08954.9 NM_201446.2_2 - 0.29 10.6 4.3 0.29 10.6 1.9 2.2 2 0 0 2 2 2 0 Trimerisation motif IN_DBD_C PF00552.19 NM_199341.3_3 - 0.14 11.3 1.4 1.7 7.9 0.2 2.8 3 0 0 3 3 3 0 Integrase DNA binding domain FAR1 PF03101.13 NM_199341.3_3 - 0.17 12.5 0.0 0.35 11.5 0.0 1.5 1 0 0 1 1 1 0 FAR1 DNA-binding domain PELOTA_1 PF15608.4 NM_199341.3_3 - 0.18 11.6 0.2 0.35 10.6 0.2 1.4 1 0 0 1 1 1 0 PELOTA RNA binding domain Laminin_EGF PF00053.22 NM_153334.6_1 - 9.4e-19 67.2 173.5 0.15 12.1 15.9 10.7 2 1 8 10 10 10 9 Laminin EGF domain EGF_2 PF07974.11 NM_153334.6_1 - 0.0085 16.3 11.6 0.0085 16.3 11.6 14.1 11 4 3 14 14 14 7 EGF-like domain PHD_4 PF16866.3 NM_006782.3_1 - 0.079 12.9 0.3 0.079 12.9 0.3 2.3 2 0 0 2 2 2 0 PHD-finger PHD PF00628.27 NM_006782.3_1 - 0.8 9.5 15.0 0.079 12.7 1.8 2.6 1 1 1 2 2 2 0 PHD-finger Zn_ribbon_17 PF17120.3 NM_006782.3_1 - 1 8.9 11.5 0.31 10.5 0.8 2.5 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type TMEM189_B_dmain PF10520.7 NM_001162505.1_3 - 1.2e-71 240.4 2.0 1.6e-71 239.9 2.0 1.1 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain TPR_19 PF14559.4 NM_001144923.2_1 - 3.3e-10 40.2 10.7 0.00059 20.2 0.8 5.1 5 1 1 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001144923.2_1 - 6e-05 23.0 20.0 0.12 12.5 1.1 5.2 3 2 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 NM_001144923.2_1 - 0.0011 19.1 1.6 0.0076 16.4 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001144923.2_1 - 0.0014 19.1 0.5 6.4 7.7 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001144923.2_1 - 0.0017 18.4 0.8 0.12 12.5 0.3 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001144923.2_1 - 0.006 16.2 9.3 0.08 12.7 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001144923.2_1 - 0.0089 15.9 0.7 9.2 6.4 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001144923.2_1 - 0.033 14.3 4.0 2.9 8.1 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001144923.2_1 - 0.061 13.4 4.2 0.07 13.2 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001144923.2_1 - 0.065 13.3 19.3 1.7 8.8 0.1 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat fn3 PF00041.19 NM_001242637.1_1 - 1.3e-22 79.8 14.1 3.1e-08 33.7 0.0 5.1 5 0 0 5 5 5 4 Fibronectin type III domain IL6Ra-bind PF09240.8 NM_001242637.1_1 - 8.2e-08 32.4 3.6 1.4e-07 31.7 0.7 2.7 3 0 0 3 3 3 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.8 NM_001242637.1_1 - 2.1e-06 27.8 0.5 8e-06 25.9 0.4 2.0 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding IL4Ra_N PF09238.8 NM_001242637.1_1 - 0.018 15.3 0.6 0.018 15.3 0.6 2.3 2 0 0 2 2 2 0 Interleukin-4 receptor alpha chain, N-terminal Interfer-bind PF09294.8 NM_001242637.1_1 - 0.021 15.0 3.1 2.2 8.5 0.0 3.3 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.3 NM_001242637.1_1 - 0.053 14.0 10.0 0.055 13.9 0.0 3.6 3 1 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain Pkinase PF00069.23 NM_002497.3_2 - 4.9e-62 209.5 1.1 9.7e-62 208.6 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_002497.3_2 - 4.5e-42 144.0 0.0 8.9e-42 143.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_002497.3_2 - 2.9e-05 23.4 0.4 9.4e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.21 NM_002497.3_2 - 0.055 13.3 0.1 0.055 13.3 0.1 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family Chromo PF00385.22 NM_005189.2_2 - 3.1e-14 52.5 0.2 5.7e-14 51.6 0.2 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CBX7_C PF17218.1 NM_005189.2_2 - 1e-12 47.4 1.9 1.9e-12 46.5 1.9 1.5 1 0 0 1 1 1 1 CBX family C-terminal motif Hepatitis_core PF00906.18 NM_005189.2_2 - 0.027 13.9 3.6 0.056 12.9 3.6 1.4 1 0 0 1 1 1 0 Hepatitis core antigen Tudor-knot PF11717.6 NM_005189.2_2 - 0.075 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain PI3K_1B_p101 PF10486.7 NM_005189.2_2 - 0.23 9.1 3.6 0.32 8.6 3.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SGT1 PF07093.9 NM_001135752.1_1 - 5.5e-236 784.5 9.7 2.4e-175 584.2 0.0 2.1 2 0 0 2 2 2 2 SGT1 protein Bradykinin PF06753.10 NM_001135752.1_1 - 0.43 10.2 2.5 1.1 8.9 2.5 1.7 1 0 0 1 1 1 0 Bradykinin Homeobox PF00046.27 NM_002145.3_1 - 1.2e-21 76.2 4.7 1.9e-21 75.5 4.7 1.3 1 0 0 1 1 1 1 Homeobox domain RRM_1 PF00076.20 NM_001124756.2_1 - 5.2e-90 295.2 0.2 1.3e-23 82.5 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.16 NM_001124756.2_1 - 6.2e-28 96.7 0.8 1.4e-27 95.6 0.8 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.4 NM_001124756.2_1 - 3.7e-10 39.4 0.2 0.014 14.8 0.1 4.2 2 2 2 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001124756.2_1 - 3.7e-07 30.1 0.0 0.14 12.2 0.0 4.7 4 2 0 4 4 4 2 RNA recognition motif Limkain-b1 PF11608.6 NM_001124756.2_1 - 4.1e-06 26.7 0.7 0.13 12.2 0.2 4.5 4 1 0 4 4 4 1 Limkain b1 SET_assoc PF11767.6 NM_001124756.2_1 - 1.2e-05 24.7 0.2 8.7 5.9 0.0 4.5 4 0 0 4 4 4 2 Histone lysine methyltransferase SET associated Nup35_RRM_2 PF14605.4 NM_001124756.2_1 - 1.3e-05 24.9 0.3 7.5 6.5 0.0 4.4 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.3 NM_001124756.2_1 - 0.00023 20.8 0.0 0.87 9.4 0.0 3.8 4 0 0 4 4 4 1 Occluded RNA-recognition motif OB_RNB PF08206.9 NM_001124756.2_1 - 0.14 11.7 4.1 21 4.7 0.2 3.5 3 0 0 3 3 3 0 Ribonuclease B OB domain zf-C2H2_jaz PF12171.6 NM_052857.3_2 - 0.0004 20.5 0.0 0.00073 19.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_052857.3_2 - 0.0011 19.1 0.1 0.002 18.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type UvrD_C PF13361.4 NM_052857.3_2 - 0.026 13.8 0.6 0.034 13.4 0.6 1.2 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF1178 PF06676.9 NM_052857.3_2 - 0.043 14.1 1.8 0.093 13.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) Sec34 PF04136.13 NM_052857.3_2 - 0.043 13.6 0.4 2.4 7.9 0.1 2.2 2 0 0 2 2 2 0 Sec34-like family Homeobox_KN PF05920.9 NM_001278686.1_3 - 3e-17 62.1 0.9 5.9e-17 61.2 0.9 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 NM_001278686.1_3 - 2.4e-07 30.3 1.2 4.8e-07 29.4 1.2 1.5 1 0 0 1 1 1 1 Homeobox domain Homez PF11569.6 NM_001278686.1_3 - 0.14 11.5 0.5 0.28 10.6 0.2 1.6 1 1 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez HAUS4 PF14735.4 NM_001166270.1_2 - 2.7e-77 259.5 23.1 2.7e-77 259.5 22.5 1.3 1 1 0 1 1 1 1 HAUS augmin-like complex subunit 4 HCMV_UL139 PF12507.6 NM_001166270.1_2 - 0.092 13.0 3.4 0.18 12.0 3.4 1.4 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein LRR_8 PF13855.4 NM_002345.3_3 - 1e-35 121.2 28.5 6.3e-11 41.7 5.1 6.6 5 2 1 6 6 6 5 Leucine rich repeat LRR_4 PF12799.5 NM_002345.3_3 - 7.8e-21 73.6 32.8 6.6e-07 29.4 0.1 6.8 1 1 8 9 9 9 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 NM_002345.3_3 - 8e-09 34.7 18.4 0.87 9.7 0.0 8.8 9 0 0 9 9 9 4 Leucine Rich repeat LRRNT PF01462.16 NM_002345.3_3 - 1.2e-07 31.1 3.3 1.2e-07 31.1 3.3 2.2 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 NM_002345.3_3 - 1.5e-07 31.0 9.2 0.0086 15.5 0.8 3.6 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.31 NM_002345.3_3 - 7.5e-07 28.6 24.1 7 7.4 0.7 9.6 8 3 0 8 8 8 3 Leucine Rich Repeat LRR_5 PF13306.4 NM_002345.3_3 - 2.7e-06 27.2 4.7 0.0027 17.6 0.2 3.5 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) Sushi PF00084.18 NM_000186.3_1 - 7.4e-160 519.5 145.4 3.5e-11 43.4 0.4 20.2 19 1 1 20 20 20 19 Sushi repeat (SCR repeat) Sushi_2 PF09014.8 NM_000186.3_1 - 0.082 12.8 0.1 0.082 12.8 0.1 7.2 6 4 2 8 8 8 0 Beta-2-glycoprotein-1 fifth domain zf-H2C2_2 PF13465.4 NM_199426.1_2 - 1e-38 129.9 83.0 2.6e-07 30.6 2.6 11.4 11 1 0 11 11 11 8 Zinc-finger double domain zf-H2C2_5 PF13909.4 NM_199426.1_2 - 5.4e-37 125.1 71.5 2.8e-08 33.2 2.7 10.3 10 0 0 10 10 10 9 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 NM_199426.1_2 - 1.9e-30 103.4 90.1 0.00054 20.1 3.6 11.2 11 0 0 11 11 11 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_199426.1_2 - 2.4e-18 65.1 87.6 0.013 16.2 1.6 11.6 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_199426.1_2 - 1.4e-08 34.4 1.4 1.4e-08 34.4 1.4 9.7 11 0 0 11 11 11 3 C2H2-type zinc finger zf-met PF12874.5 NM_199426.1_2 - 6.7e-06 26.2 64.8 0.00067 19.8 0.4 9.5 9 1 0 9 9 9 6 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_199426.1_2 - 0.015 14.9 0.1 0.015 14.9 0.1 7.2 8 0 0 8 8 8 0 zinc-finger C2H2-type V-set PF07686.15 NM_016543.3_1 - 1.3e-15 57.3 3.1 3.8e-12 46.2 0.1 3.8 2 2 2 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_016543.3_1 - 1.7e-12 47.7 0.2 3.6e-07 30.6 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.14 NM_016543.3_1 - 4.4e-11 42.6 0.0 7.8e-07 28.9 0.0 3.3 2 2 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_016543.3_1 - 6.8e-10 39.0 0.8 8e-08 32.4 0.0 2.7 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 NM_016543.3_1 - 5.2e-08 32.8 0.7 0.0037 17.3 0.2 3.3 2 1 0 2 2 2 2 Immunoglobulin domain p450 PF00067.20 NM_001320290.1_2 - 1.6e-113 379.8 0.0 2e-113 379.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-C2H2_8 PF15909.3 NM_001146175.1_2 - 1.8e-58 194.7 12.1 3.2e-58 193.9 12.1 1.4 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_6 PF13912.4 NM_001146175.1_2 - 0.00027 20.7 10.9 0.072 12.9 0.2 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_4 PF13894.4 NM_001146175.1_2 - 0.0013 19.2 24.3 0.32 11.8 0.5 4.3 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_001146175.1_2 - 0.0016 18.0 0.1 0.0016 18.0 0.1 2.8 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 NM_001146175.1_2 - 0.0048 17.2 22.1 0.75 10.2 0.2 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001146175.1_2 - 0.013 15.8 9.7 0.17 12.2 1.5 3.6 3 0 0 3 3 3 0 Zinc-finger double domain Xlink PF00193.15 NM_021817.2_3 - 9.3e-59 195.7 0.0 9e-32 109.2 0.0 2.5 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.15 NM_021817.2_3 - 4.4e-11 42.8 0.0 8e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_021817.2_3 - 2e-06 28.2 0.0 4.2e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_021817.2_3 - 0.00021 21.2 0.0 0.00039 20.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_021817.2_3 - 0.0009 19.2 0.0 0.002 18.1 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_021817.2_3 - 0.0075 16.5 0.0 0.035 14.3 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.3 NM_021817.2_3 - 0.011 15.6 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain zf-H2C2_2 PF13465.4 NM_138494.2_1 - 2.1e-29 100.5 75.2 1e-07 31.9 2.0 12.9 11 1 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_138494.2_1 - 3.9e-25 86.7 77.6 4.4e-05 23.6 2.6 10.2 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_138494.2_1 - 1.3e-09 38.0 77.4 0.0064 17.1 2.4 9.7 9 0 0 9 9 9 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_138494.2_1 - 0.0017 18.3 37.3 0.059 13.4 1.7 5.3 5 1 0 5 5 5 3 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_138494.2_1 - 0.13 12.1 54.9 0.21 11.5 2.1 8.2 7 1 0 7 7 7 0 C2H2-type zinc finger XPA_N PF01286.16 NM_138494.2_1 - 1.1 9.2 31.8 14 5.7 0.6 7.6 7 0 0 7 7 7 0 XPA protein N-terminal Chordopox_RPO7 PF05864.10 NM_138494.2_1 - 2.5 8.3 8.2 79 3.5 0.3 4.6 5 0 0 5 5 5 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zf-C2H2_jaz PF12171.6 NM_138494.2_1 - 8.6 6.7 36.3 1.2 9.4 0.4 7.0 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.4 NM_138494.2_3 - 0.4 11.1 21.7 0.19 12.1 0.6 4.0 4 0 0 4 4 4 0 Zinc-finger double domain Sulfatase PF00884.21 NM_000199.3_1 - 6.8e-57 193.1 0.0 1.8e-56 191.7 0.0 1.6 1 1 0 1 1 1 1 Sulfatase DUF4976 PF16347.3 NM_000199.3_1 - 8.7e-09 35.4 0.4 1.7e-08 34.5 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.20 NM_000199.3_1 - 8.8e-07 28.7 0.0 2.3e-05 24.0 0.0 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.10 NM_000199.3_1 - 0.056 12.4 0.2 0.097 11.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DUF229 PF02995.15 NM_000199.3_1 - 0.057 11.9 0.0 0.084 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) 7tm_1 PF00001.19 NM_002511.3_1 - 1.6e-53 181.5 10.4 1.6e-53 181.5 10.4 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) MRP-S28 PF10213.7 NM_021821.3_3 - 4e-21 75.6 0.2 7.4e-21 74.8 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Abhydrolase_1 PF00561.18 NM_148912.3_2 - 9.9e-24 84.2 0.1 1.6e-22 80.3 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_148912.3_2 - 2.3e-23 83.8 1.3 3.8e-23 83.1 1.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 NM_148912.3_2 - 1.1e-15 57.4 0.1 1.6e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.11 NM_148912.3_2 - 1.6e-07 31.2 0.3 0.0027 17.3 0.1 2.1 1 1 1 2 2 2 2 PGAP1-like protein Esterase PF00756.18 NM_148912.3_2 - 6.7e-06 25.8 0.0 0.00011 21.8 0.0 2.2 1 1 0 1 1 1 1 Putative esterase Thioesterase PF00975.18 NM_148912.3_2 - 1.4e-05 25.2 0.0 2.5e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.23 NM_148912.3_2 - 0.00045 20.0 0.0 0.00082 19.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) PAF-AH_p_II PF03403.11 NM_148912.3_2 - 0.002 16.6 0.0 0.15 10.4 0.0 2.2 1 1 1 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase PF07224.9 NM_148912.3_2 - 0.0062 15.5 0.0 0.014 14.3 0.0 1.6 1 1 0 1 1 1 1 Chlorophyllase Chlorophyllase2 PF12740.5 NM_148912.3_2 - 0.0067 15.2 0.0 0.017 13.9 0.0 1.6 1 1 0 1 1 1 1 Chlorophyllase enzyme Ndr PF03096.12 NM_148912.3_2 - 0.023 13.3 0.0 0.031 12.8 0.0 1.2 1 0 0 1 1 1 0 Ndr family DLH PF01738.16 NM_148912.3_2 - 0.051 13.0 0.0 5 6.5 0.0 3.0 2 1 0 2 2 2 0 Dienelactone hydrolase family DUF915 PF06028.9 NM_148912.3_2 - 0.14 11.3 0.7 14 4.8 0.0 2.7 2 1 1 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF915) Abi_HHR PF07815.12 NM_005470.3_3 - 1.3e-35 121.2 0.5 2.1e-35 120.5 0.5 1.3 1 0 0 1 1 1 1 Abl-interactor HHR SH3_1 PF00018.26 NM_005470.3_3 - 2.6e-16 58.8 0.4 8.3e-16 57.2 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 NM_005470.3_3 - 1.9e-14 53.1 0.1 3.8e-14 52.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_005470.3_3 - 1.7e-10 40.3 0.1 2.8e-10 39.6 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain MBD PF01429.17 NM_001300905.1_3 - 3.9e-20 71.2 0.4 9.6e-20 70.0 0.4 1.7 1 0 0 1 1 1 1 Methyl-CpG binding domain Bromodomain PF00439.23 NM_001300905.1_3 - 1.7e-19 69.6 0.0 3.7e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Bromodomain WSD PF15613.4 NM_001300905.1_3 - 1.3e-13 51.2 6.7 1.4e-06 28.5 0.0 3.5 3 0 0 3 3 3 2 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD PF00628.27 NM_001300905.1_3 - 1.4e-10 40.7 8.9 4.1e-10 39.3 8.9 1.9 1 0 0 1 1 1 1 PHD-finger DDT PF02791.15 NM_001300905.1_3 - 2e-09 37.5 0.2 5.9e-09 36.0 0.2 1.9 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.4 NM_001300905.1_3 - 2.9e-05 23.4 0.0 7.6e-05 22.0 0.0 1.7 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 NTF2 PF02136.18 NM_012297.4_1 - 5.1e-32 110.8 0.1 7.6e-32 110.2 0.1 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.20 NM_012297.4_1 - 3.1e-13 49.2 0.1 5.7e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_012297.4_1 - 2.6e-05 24.1 0.0 6.2e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif PMP22_Claudin PF00822.18 NM_020384.3_1 - 5.5e-22 78.3 7.1 7.5e-22 77.8 7.1 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_020384.3_1 - 1.5e-05 24.7 8.8 3.1e-05 23.7 8.3 1.8 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.4 NM_020384.3_1 - 1.9 8.7 12.5 11 6.3 3.4 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF4064) Amastin PF07344.9 NM_020384.3_1 - 4.8 6.9 8.9 5.6 6.6 6.9 1.9 1 1 1 2 2 2 0 Amastin surface glycoprotein Ion_trans PF00520.29 NM_001129841.1_2 - 2.2e-261 862.1 80.5 9.6e-74 247.6 18.6 4.2 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 NM_001129841.1_2 - 5.3e-37 128.2 12.3 7.4e-27 94.8 0.0 3.0 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 NM_001129841.1_2 - 6.4e-36 121.9 0.0 1.2e-35 121.0 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 NM_001129841.1_2 - 5.8e-30 103.3 0.1 1.1e-29 102.3 0.1 1.5 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 NM_001129841.1_2 - 1e-08 34.2 29.9 7.2e-08 31.4 7.0 7.5 7 1 0 7 7 7 3 Polycystin cation channel 7tm_4 PF13853.4 NM_001005284.1_1 - 1.7e-50 172.2 13.4 2.2e-50 171.8 13.4 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005284.1_1 - 5.4e-20 71.6 15.7 1.8e-19 69.9 15.7 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GpcrRhopsn4 PF10192.7 NM_001005284.1_1 - 0.0019 17.5 8.2 0.064 12.5 1.1 2.2 2 0 0 2 2 2 2 Rhodopsin-like GPCR transmembrane domain DUF1270 PF06900.9 NM_001005284.1_1 - 0.17 12.1 6.4 14 6.0 0.5 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1270) SpoVAB PF13782.4 NM_001005284.1_1 - 0.51 10.5 4.8 0.29 11.3 0.6 2.4 2 0 0 2 2 2 0 Stage V sporulation protein AB Hexapep PF00132.22 NM_001199743.1_1 - 3.8e-06 26.3 15.1 0.0002 20.8 3.4 4.2 2 2 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.4 NM_001199743.1_1 - 1.2 8.8 7.6 0.43 10.3 2.7 2.6 2 1 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase RGM_C PF06534.11 NM_001166286.1_2 - 3.6e-71 238.0 0.0 4.9e-71 237.6 0.0 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus RGM_N PF06535.10 NM_001166286.1_2 - 3.2e-70 235.5 1.0 5e-70 234.9 1.0 1.3 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus Arf PF00025.19 NM_020150.4_2 - 6.8e-62 207.9 0.0 9.1e-62 207.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 NM_020150.4_2 - 2.8e-09 36.5 0.0 3.9e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 NM_020150.4_2 - 3.5e-07 30.3 0.0 5.7e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.18 NM_020150.4_2 - 5.9e-07 28.8 0.1 2.1e-05 23.8 0.0 2.1 1 1 1 2 2 2 1 G-protein alpha subunit Ras PF00071.20 NM_020150.4_2 - 3.9e-06 26.4 0.0 5.5e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.21 NM_020150.4_2 - 0.00012 22.0 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 NM_020150.4_2 - 0.0075 15.7 0.0 0.027 13.9 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRCR PF00530.16 NM_203416.3_3 - 1.4e-250 811.6 120.9 7.7e-33 112.8 8.4 9.4 10 0 0 10 10 10 9 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 NM_203416.3_3 - 1.2e-24 86.5 48.6 0.0011 19.3 0.1 9.6 9 0 0 9 9 9 8 Scavenger receptor cysteine-rich domain IncA PF04156.12 NM_203416.3_3 - 0.05 13.3 0.1 0.08 12.6 0.1 1.2 1 0 0 1 1 1 0 IncA protein RHS PF03527.12 NM_203416.3_3 - 0.052 13.2 10.9 4.5 6.9 0.1 5.9 5 0 0 5 5 5 0 RHS protein eIF_4EBP PF05456.9 NM_001017397.1_1 - 1 9.2 5.3 1.6 8.6 5.3 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Ras PF00071.20 NM_016577.3_1 - 3.1e-57 192.6 0.3 4.5e-57 192.0 0.3 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_016577.3_1 - 2e-34 118.2 0.1 3.1e-34 117.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_016577.3_1 - 9.4e-14 51.1 0.1 1.4e-13 50.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 NM_016577.3_1 - 0.00023 20.6 0.1 0.00041 19.8 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 NM_016577.3_1 - 0.00061 19.1 0.1 0.00096 18.5 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 NM_016577.3_1 - 0.002 18.1 0.0 0.0031 17.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_016577.3_1 - 0.0055 15.9 0.3 0.0077 15.5 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 NM_016577.3_1 - 0.021 14.6 0.1 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 FeoB_N PF02421.16 NM_016577.3_1 - 0.021 14.2 0.2 0.11 11.9 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B cNMP_binding PF00027.27 NM_001166113.1_2 - 3.1e-51 171.2 0.1 7.5e-17 61.0 0.0 3.5 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Patatin PF01734.20 NM_001166113.1_2 - 2.1e-23 83.4 0.1 3.9e-23 82.5 0.1 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase PAP_central PF04928.15 NM_001252007.1_1 - 0.017 13.9 0.1 0.024 13.5 0.1 1.1 1 0 0 1 1 1 0 Poly(A) polymerase central domain PAP_central PF04928.15 NM_001252007.1_2 - 7.1e-65 218.3 3.6 1.9e-26 92.4 0.0 3.1 3 0 0 3 3 3 3 Poly(A) polymerase central domain NTP_transf_2 PF01909.21 NM_001252007.1_2 - 5.4e-13 48.9 0.1 8.7e-13 48.3 0.1 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain bPH_3 PF14470.4 NM_001252007.1_3 - 0.027 14.7 0.0 0.045 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial PH domain EF-hand_7 PF13499.4 NM_016257.3_3 - 3.6e-22 78.5 4.2 1.1e-14 54.5 1.0 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 NM_016257.3_3 - 7.5e-20 68.8 12.2 1.2e-06 27.5 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_016257.3_3 - 2.2e-18 64.4 4.5 2.8e-06 26.7 0.1 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.4 NM_016257.3_3 - 8.1e-12 44.0 11.1 8.4e-05 21.8 0.3 4.1 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 NM_016257.3_3 - 3.4e-10 39.4 5.4 5.5e-05 22.7 1.6 3.0 2 1 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_016257.3_3 - 0.11 12.7 2.1 6.5 7.0 0.7 3.1 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.11 NM_016257.3_3 - 0.37 10.6 2.3 5 6.9 2.3 2.6 1 1 0 1 1 1 0 Caleosin related protein Ig_2 PF13895.4 NM_002000.3_3 - 9e-11 41.8 0.0 0.00031 20.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_002000.3_3 - 2e-07 31.0 0.0 0.0016 18.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_002000.3_3 - 8.3e-07 29.4 0.0 0.0035 17.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain 7tm_2 PF00002.22 NM_001304522.1_1 - 1.2e-62 211.3 3.1 1.7e-62 210.8 3.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_001304522.1_1 - 4.5e-22 78.0 4.8 4.5e-22 78.0 4.8 3.0 3 0 0 3 3 3 1 Hormone receptor domain DUF2628 PF10947.6 NM_001304522.1_1 - 0.85 9.9 3.3 0.42 10.9 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) AIB PF15334.4 NM_024037.2_3 - 8.1e-182 603.6 9.9 9.6e-182 603.4 9.9 1.0 1 0 0 1 1 1 1 Aurora kinase A and ninein interacting protein CCSAP PF15748.3 NM_145257.4_1 - 2.8e-97 325.7 19.2 3.5e-97 325.4 19.2 1.1 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated tRNA-synt_His PF13393.4 NM_001278732.1_3 - 7.5e-21 74.6 0.0 3e-19 69.3 0.0 2.1 1 1 1 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.18 NM_001278732.1_3 - 1.2e-16 60.5 0.1 2e-16 59.8 0.1 1.3 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.5 NM_001278732.1_3 - 5.5e-09 35.7 0.1 7.9e-09 35.2 0.1 1.2 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs Auts2 PF15336.4 NM_001142641.1_1 - 1.1e-90 303.5 7.0 1.1e-90 303.5 7.0 4.0 4 1 0 4 4 4 1 Autism susceptibility gene 2 protein MHC_I PF00129.16 NM_139007.2_2 - 1.5e-22 79.9 0.1 2.3e-22 79.3 0.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_139007.2_2 - 1.7e-13 50.7 0.0 2.8e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 NM_139007.2_2 - 0.00072 19.0 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain Ig_2 PF13895.4 NM_139007.2_2 - 0.00088 19.4 0.0 0.0021 18.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain DUF912 PF06024.10 NM_139007.2_2 - 0.12 12.5 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) SKG6 PF08693.8 NM_139007.2_2 - 0.29 10.5 3.4 0.51 9.7 3.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RNA_pol_Rpb2_6 PF00562.26 NM_001137604.2_2 - 2.3e-117 392.2 0.0 4.9e-117 391.2 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_3 PF04565.14 NM_001137604.2_2 - 2.1e-27 94.9 0.0 3.7e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.18 NM_001137604.2_2 - 5.7e-22 77.8 0.0 1.2e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_1 PF04563.13 NM_001137604.2_2 - 2.7e-21 75.9 0.0 9.2e-21 74.2 0.0 1.7 1 1 1 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpa2_4 PF06883.10 NM_001137604.2_2 - 2.6e-19 68.8 0.0 4.9e-19 68.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.12 NM_001137604.2_2 - 1.5e-12 47.4 0.0 2.2e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 DUF1186 PF06685.9 NM_001137604.2_2 - 0.049 12.9 0.0 0.085 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) Cadherin PF00028.15 NM_001168362.1_3 - 4.4e-103 337.8 5.0 2.1e-19 69.6 0.2 7.5 7 0 0 7 7 7 6 Cadherin domain Protocadherin PF08374.9 NM_001168362.1_3 - 1.6e-82 276.6 5.5 2.5e-82 276.0 5.5 1.3 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.10 NM_001168362.1_3 - 5.1e-20 70.9 0.9 5.1e-08 32.5 0.0 5.5 6 0 0 6 6 6 4 Cadherin-like Cadherin_3 PF16184.3 NM_001168362.1_3 - 0.00053 19.9 15.8 0.97 9.3 0.2 5.3 5 0 0 5 5 5 3 Cadherin-like FAM47 PF14642.4 NM_001168362.1_3 - 0.0027 17.1 7.4 0.0027 17.1 7.4 2.3 1 1 1 2 2 2 2 FAM47 family Drf_FH1 PF06346.10 NM_001168362.1_3 - 0.052 13.1 9.0 0.12 12.0 9.0 1.5 1 0 0 1 1 1 0 Formin Homology Region 1 NCOA_u2 PF16665.3 NM_001321713.1_1 - 7.3e-37 126.1 17.6 7.3e-37 126.1 17.6 5.0 3 2 1 4 4 4 1 Unstructured region on nuclear receptor coactivator protein PAS_11 PF14598.4 NM_001321713.1_1 - 2.3e-36 124.2 0.7 1.6e-33 115.1 1.1 2.6 2 0 0 2 2 2 2 PAS domain DUF4927 PF16279.3 NM_001321713.1_1 - 9e-32 109.8 5.9 2.2e-31 108.6 5.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4927) DUF1518 PF07469.10 NM_001321713.1_1 - 3.4e-25 88.1 19.7 3.4e-25 88.1 19.7 4.1 3 1 0 3 3 3 1 Domain of unknown function (DUF1518) Nuc_rec_co-act PF08815.8 NM_001321713.1_1 - 1.5e-24 85.5 0.8 3e-24 84.5 0.8 1.6 1 0 0 1 1 1 1 Nuclear receptor coactivator SRC-1 PF08832.8 NM_001321713.1_1 - 3.8e-20 72.6 5.8 3.8e-20 72.6 5.8 3.4 4 0 0 4 4 4 1 Steroid receptor coactivator PAS_3 PF08447.10 NM_001321713.1_1 - 5.7e-07 29.6 0.1 0.034 14.3 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 NM_001321713.1_1 - 8e-06 25.7 0.5 2.7e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.5 NM_001321713.1_1 - 0.00011 22.3 0.0 0.00028 21.0 0.0 1.7 1 0 0 1 1 1 1 PAS domain HLH PF00010.24 NM_001321713.1_3 - 0.054 13.3 0.7 0.11 12.4 0.7 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain PhoLip_ATPase_C PF16212.3 NM_198531.4_2 - 9.8e-52 176.0 19.2 9.8e-52 176.0 19.2 2.0 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 NM_198531.4_2 - 2.6e-18 65.4 2.1 3.4e-18 65.0 0.9 1.8 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.24 NM_198531.4_2 - 1.5e-13 51.4 0.1 4.9e-11 43.2 0.1 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.18 NM_198531.4_2 - 2.4e-13 49.8 0.0 5e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.4 NM_198531.4_2 - 5.5e-08 32.7 0.2 3.8e-07 30.0 0.0 2.5 3 1 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.10 NM_198531.4_2 - 0.0038 16.9 0.0 0.0085 15.7 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase GNVR PF13807.4 NM_198531.4_2 - 0.047 13.5 0.2 0.12 12.1 0.2 1.7 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase ParA PF10609.7 NM_001323597.1_2 - 2.6e-92 308.6 0.1 3.3e-92 308.2 0.1 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.21 NM_001323597.1_2 - 7.2e-11 42.1 0.0 1.7e-10 40.9 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.4 NM_001323597.1_2 - 2e-08 34.2 0.0 0.00021 21.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain ArsA_ATPase PF02374.13 NM_001323597.1_2 - 9.4e-07 28.2 0.3 1.7e-05 24.1 0.0 2.3 2 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.9 NM_001323597.1_2 - 0.00019 20.7 0.1 0.00074 18.7 0.1 1.9 1 1 0 1 1 1 1 ATPase MipZ DUF258 PF03193.14 NM_001323597.1_2 - 0.0011 18.7 0.3 0.0038 17.0 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_25 PF13481.4 NM_001323597.1_2 - 0.0095 15.4 0.1 0.015 14.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.3 NM_001323597.1_2 - 0.012 15.3 0.0 0.046 13.4 0.0 1.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_26 PF13500.4 NM_001323597.1_2 - 0.013 15.2 0.1 2.4 7.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.10 NM_001323597.1_2 - 0.023 14.5 0.1 0.039 13.7 0.1 1.3 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.20 NM_001323597.1_2 - 0.024 13.6 0.1 0.033 13.1 0.1 1.1 1 0 0 1 1 1 0 NB-ARC domain TsaE PF02367.15 NM_001323597.1_2 - 0.029 14.2 0.1 0.05 13.5 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF87 PF01935.15 NM_001323597.1_2 - 0.03 14.2 0.1 0.046 13.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF87 Fer4_NifH PF00142.16 NM_001323597.1_2 - 0.045 13.1 0.0 0.085 12.1 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family PcrB PF01884.15 NM_001323597.1_2 - 0.047 13.0 0.2 0.1 11.9 0.0 1.6 2 0 0 2 2 2 0 PcrB family DAP3 PF10236.7 NM_001323597.1_2 - 0.047 12.7 0.1 0.082 11.9 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 SRP54 PF00448.20 NM_001323597.1_2 - 0.11 11.9 0.0 0.26 10.8 0.0 1.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.20 NM_001323597.1_2 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase DnaB_C PF03796.13 NM_001323597.1_2 - 0.16 11.1 0.0 0.26 10.4 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain CBP_BcsQ PF06564.10 NM_001323597.1_2 - 0.17 11.2 0.0 0.68 9.3 0.0 1.9 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ DUF1619 PF07773.9 NM_024549.5_1 - 2.3e-62 211.7 17.6 2.3e-39 136.1 11.3 2.7 4 0 0 4 4 4 2 Protein of unknown function (DUF1619) SH3_9 PF14604.4 NM_001018003.2_2 - 8.9e-42 140.6 0.6 2.4e-14 52.8 0.1 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 NM_001018003.2_2 - 6.2e-38 128.0 0.2 2.6e-12 46.0 0.0 3.3 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 NM_001018003.2_2 - 4.5e-30 103.0 0.6 2.1e-11 43.2 0.0 3.3 3 0 0 3 3 3 3 Variant SH3 domain KTI12 PF08433.8 NM_138417.2_1 - 3.3e-108 361.1 0.0 4e-108 360.9 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.4 NM_138417.2_1 - 0.00015 21.8 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.18 NM_138417.2_1 - 0.16 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF2151 PF10221.7 NM_018164.2_1 - 4.2e-289 960.8 4.5 4.9e-289 960.5 4.5 1.0 1 0 0 1 1 1 1 Cell cycle and development regulator COG2 PF06148.9 NM_001145036.1_2 - 2.5e-43 147.2 5.4 2.5e-43 147.2 5.4 2.8 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.6 NM_001145036.1_2 - 8.7e-42 142.3 0.7 2.8e-41 140.7 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3510) Vps51 PF08700.9 NM_001145036.1_2 - 0.0075 16.2 2.4 0.02 14.8 0.2 2.6 2 0 0 2 2 2 1 Vps51/Vps67 Reo_sigmaC PF04582.10 NM_001145036.1_2 - 0.43 9.8 5.7 0.11 11.7 0.8 2.2 2 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF1664 PF07889.10 NM_001145036.1_2 - 0.44 10.4 5.5 0.7 9.8 1.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) COG5 PF10392.7 NM_001145036.1_2 - 1.2 9.1 11.5 0.14 12.2 1.3 3.4 3 1 1 4 4 4 0 Golgi transport complex subunit 5 Syntaxin_2 PF14523.4 NM_001145036.1_2 - 4.8 7.5 7.4 14 6.0 1.1 3.7 3 2 1 4 4 4 0 Syntaxin-like protein Ets PF00178.20 NM_005240.1_1 - 1.4e-33 115.1 2.6 2.2e-33 114.4 2.6 1.3 1 0 0 1 1 1 1 Ets-domain Aldo_ket_red PF00248.19 NM_001354.5_3 - 4e-57 193.5 0.0 5e-57 193.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Galactosyl_T PF01762.19 NM_152490.4_2 - 1.7e-26 93.1 0.0 2.9e-23 82.6 0.0 2.2 2 0 0 2 2 2 2 Galactosyltransferase PDZ PF00595.22 NM_080683.2_1 - 4.1e-76 251.2 8.6 6.6e-18 64.7 0.8 5.5 5 0 0 5 5 5 5 PDZ domain (Also known as DHR or GLGF) Y_phosphatase PF00102.25 NM_080683.2_1 - 2.3e-73 246.5 0.0 4.3e-73 245.6 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTN13_u3 PF16599.3 NM_080683.2_1 - 3.4e-73 245.7 24.2 3.4e-73 245.7 24.2 3.5 4 0 0 4 4 4 1 Unstructured linker region on PTN13 protein between PDZ FERM_M PF00373.16 NM_080683.2_1 - 9e-28 96.9 1.2 2.9e-27 95.3 1.2 2.0 1 0 0 1 1 1 1 FERM central domain PDZ_2 PF13180.4 NM_080683.2_1 - 1.9e-24 85.7 7.0 2.9e-05 24.2 0.0 5.5 5 0 0 5 5 5 4 PDZ domain FERM_C PF09380.8 NM_080683.2_1 - 1.2e-20 73.6 1.3 1.5e-19 70.0 0.5 2.5 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_080683.2_1 - 4.2e-16 58.5 0.1 9.5e-16 57.4 0.1 1.7 1 0 0 1 1 1 1 FERM N-terminal domain KIND PF16474.3 NM_080683.2_1 - 1.7e-05 24.6 0.0 0.00015 21.6 0.0 2.5 1 1 1 2 2 2 1 Kinase non-catalytic C-lobe domain DSPc PF00782.18 NM_080683.2_1 - 0.0025 17.5 0.0 0.008 15.9 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CYTH PF01928.19 NM_001126339.3_3 - 4.7e-38 130.8 0.0 6.8e-38 130.3 0.0 1.2 1 0 0 1 1 1 1 CYTH domain HMG14_17 PF01101.16 NM_005517.3_2 - 1.2e-31 109.3 26.2 1.7e-31 108.9 26.2 1.2 1 0 0 1 1 1 1 HMG14 and HMG17 Sema PF01403.17 NM_001146029.2_3 - 4.2e-81 272.7 0.3 1.9e-80 270.6 0.0 2.1 2 1 0 2 2 2 1 Sema domain Ig_2 PF13895.4 NM_001146029.2_3 - 3.9e-07 30.2 0.4 1e-06 28.8 0.4 1.7 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 NM_001146029.2_3 - 5.9e-07 29.8 2.4 2.6e-06 27.8 2.4 2.2 1 0 0 1 1 1 1 Plexin repeat Ig_3 PF13927.4 NM_001146029.2_3 - 0.00035 21.0 0.2 0.00078 19.9 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ank_2 PF12796.5 NM_003560.2_2 - 3.8e-41 139.4 13.2 4.6e-10 39.8 0.2 4.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_003560.2_2 - 2.1e-34 117.3 1.5 1.9e-07 31.4 0.1 6.5 5 1 1 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.28 NM_003560.2_2 - 1.8e-31 107.1 6.8 1.7e-05 24.9 0.0 7.6 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.4 NM_003560.2_2 - 2.1e-29 101.0 7.2 2.9e-11 43.3 1.3 6.4 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_003560.2_2 - 3e-26 88.4 5.9 0.00018 21.6 0.0 7.7 6 1 0 6 6 6 5 Ankyrin repeat Patatin PF01734.20 NM_003560.2_2 - 3.7e-16 59.7 5.0 3.1e-15 56.8 5.0 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase Kinesin PF00225.21 NM_145754.3_3 - 3.1e-82 276.0 0.0 4.9e-82 275.4 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 NM_145754.3_3 - 9.6e-34 116.3 0.0 1.5e-33 115.7 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding Baculo_PEP_C PF04513.10 NM_145754.3_3 - 0.34 10.8 2.7 0.36 10.7 0.1 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Filament PF00038.19 NM_145754.3_3 - 1.8 7.9 11.9 1.4 8.3 3.0 2.1 2 0 0 2 2 2 0 Intermediate filament protein Fib_alpha PF08702.8 NM_145754.3_3 - 3.1 7.8 5.9 0.82 9.7 0.6 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family TBPIP PF07106.11 NM_145754.3_3 - 6 6.5 8.2 4.3 7.0 0.9 2.1 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) GIT_CC PF16559.3 NM_145754.3_3 - 7.7 6.5 8.5 8.1 6.4 0.2 2.7 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor IncA PF04156.12 NM_145754.3_3 - 8.7 6.0 27.7 0.31 10.7 8.5 2.3 1 1 1 2 2 2 0 IncA protein AIRS_C PF02769.20 NM_001195602.1_2 - 3.2e-30 105.2 0.1 4.6e-30 104.7 0.1 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 NM_001195602.1_2 - 4.2e-10 40.0 0.3 8.4e-10 39.1 0.3 1.4 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain DUF4604 PF15377.4 NM_080650.3_1 - 4.4 7.6 21.0 6.2 7.1 21.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Diphthami_syn_2 PF01902.15 NM_080650.3_3 - 2.9e-44 151.0 0.2 5.7e-44 150.1 0.2 1.4 1 1 0 1 1 1 1 Diphthamide synthase OAD_gamma PF04277.11 NM_080650.3_3 - 0.24 11.9 3.8 0.66 10.5 3.8 1.8 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain A_deaminase PF00962.20 NM_001172431.1_2 - 1.9e-136 454.6 0.0 3.6e-136 453.7 0.0 1.4 1 1 0 1 1 1 1 Adenosine/AMP deaminase DUF2384 PF09722.8 NM_001145282.2_1 - 0.12 12.3 0.2 0.63 10.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2384) 7tm_1 PF00001.19 NM_001145282.2_3 - 5.4e-59 199.5 28.2 8.2e-59 198.9 28.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001145282.2_3 - 4.5e-09 35.9 26.8 5.7e-09 35.6 26.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001145282.2_3 - 1.1e-05 24.8 28.2 1.7e-05 24.2 28.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 NM_001145282.2_3 - 0.001 18.7 20.7 0.0023 17.6 20.7 1.5 1 1 0 1 1 1 1 Olfactory receptor MWFE PF15879.3 NM_001145282.2_3 - 0.26 11.3 0.9 1.1 9.3 0.1 2.4 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit DMRT-like PF15791.3 NM_001145282.2_3 - 0.42 10.9 3.6 0.54 10.6 2.7 1.6 1 1 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 zf-H2C2_2 PF13465.4 NM_182609.3_2 - 4.7e-78 254.3 80.2 1.1e-08 35.0 1.3 12.9 12 0 0 12 12 12 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_182609.3_2 - 5.4e-61 199.7 77.5 3.3e-07 30.3 1.0 11.5 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_182609.3_2 - 3.5e-26 89.5 71.4 0.018 15.7 0.7 11.3 10 0 0 10 10 10 10 C2H2-type zinc finger KRAB PF01352.25 NM_182609.3_2 - 5e-26 90.0 0.3 1.3e-25 88.6 0.3 1.8 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_182609.3_2 - 1.5e-12 47.0 58.1 0.08 12.8 0.5 11.0 10 0 0 10 10 10 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_182609.3_2 - 6.9e-08 32.4 52.9 0.59 10.2 3.5 8.4 4 2 2 8 8 8 6 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_182609.3_2 - 0.00014 21.4 40.4 0.2 11.3 0.1 9.1 9 0 0 9 9 9 5 zinc-finger C2H2-type XPA_N PF01286.16 NM_182609.3_2 - 0.00016 21.5 36.1 9.9 6.2 0.0 9.6 9 0 0 9 9 9 1 XPA protein N-terminal zf-H2C2_5 PF13909.4 NM_182609.3_2 - 0.0062 16.1 0.6 0.0062 16.1 0.6 11.9 10 4 0 10 10 10 2 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.3 NM_182609.3_2 - 0.075 13.7 46.3 2.9 8.6 2.0 6.0 5 0 0 5 5 5 0 zinc-ribbon family zinc_ribbon_9 PF14369.4 NM_182609.3_2 - 0.26 11.4 28.1 35 4.6 0.1 9.4 10 0 0 10 10 9 0 zinc-ribbon DUF3268 PF11672.6 NM_182609.3_2 - 4.1 7.7 35.3 1.4 9.1 0.3 5.6 4 1 0 5 5 5 0 zinc-finger-containing domain BolA PF01722.16 NM_182609.3_2 - 5 7.4 16.0 26 5.1 0.1 5.3 3 2 1 5 5 5 0 BolA-like protein zf-C2H2 PF00096.24 NM_182609.3_3 - 0.77 10.2 5.3 0.44 11.0 1.1 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-A20 PF01754.14 NM_001242912.1_3 - 3.3e-12 46.0 8.8 8.9e-12 44.6 8.8 1.8 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.14 NM_001242912.1_3 - 6.8e-09 35.6 7.7 6.8e-09 35.6 7.7 2.5 2 0 0 2 2 2 1 AN1-like Zinc finger Abhydrolase_1 PF00561.18 NM_177524.2_1 - 1.2e-16 61.0 0.1 1.1e-14 54.6 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_177524.2_1 - 4.3e-10 40.5 0.1 6.5e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1057 PF06342.10 NM_177524.2_1 - 3.1e-05 23.0 0.0 4.4e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Hydrolase_4 PF12146.6 NM_177524.2_1 - 0.00035 19.8 0.0 0.0045 16.2 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 7TM_GPCR_Srx PF10328.7 NM_001039165.2_2 - 4.5e-06 26.1 3.1 7.8e-06 25.3 3.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.19 NM_001039165.2_2 - 0.0011 18.2 12.4 0.0011 18.2 12.4 2.1 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) CReP_N PF10472.7 NM_001320839.1_2 - 0.038 12.7 0.0 0.052 12.3 0.0 1.1 1 0 0 1 1 1 0 eIF2-alpha phosphatase phosphorylation constitutive repressor DUF3685 PF12452.6 NM_001320839.1_2 - 0.054 13.1 0.0 0.068 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) LRR_1 PF00560.31 NM_001320839.1_2 - 0.3 11.6 3.3 8.1 7.2 0.1 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat DFP PF04127.13 NM_001287506.1_3 - 9.9e-10 38.4 0.0 1.4e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein Collectrin PF16959.3 NM_001287506.1_3 - 0.033 13.8 0.3 0.058 13.0 0.3 1.3 1 0 0 1 1 1 0 Renal amino acid transporter FERM_C PF09380.8 NM_001282983.1_3 - 8.1e-25 86.9 0.1 1.3e-24 86.2 0.1 1.3 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_001282983.1_3 - 7.5e-17 60.9 0.1 1.8e-16 59.7 0.0 1.7 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.16 NM_001282983.1_3 - 1.4e-16 60.8 0.6 2.5e-16 60.0 0.6 1.4 1 0 0 1 1 1 1 FERM central domain FA PF08736.9 NM_001282983.1_3 - 1.2e-15 57.2 5.2 3.3e-15 55.8 5.2 1.8 1 0 0 1 1 1 1 FERM adjacent (FA) RhoGEF PF00621.18 NM_001282983.1_3 - 7.8e-15 55.4 0.0 2.1e-14 54.0 0.0 1.7 2 0 0 2 2 2 1 RhoGEF domain LANC_like PF05147.11 NM_001136574.1_1 - 7.1e-106 353.6 0.5 9.1e-106 353.2 0.5 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Glyco_hydro_127 PF07944.10 NM_001136574.1_1 - 0.013 13.9 0.2 2.7 6.3 0.0 2.1 2 0 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Use1 PF09753.7 NM_005868.5_2 - 0.00059 19.5 0.3 0.00082 19.0 0.3 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 Sec20 PF03908.11 NM_005868.5_2 - 0.0022 17.7 0.5 0.0032 17.2 0.5 1.2 1 0 0 1 1 1 1 Sec20 Occludin_ELL PF07303.11 NM_025165.2_2 - 6.4e-29 100.5 7.5 9.8e-29 99.9 7.5 1.3 1 0 0 1 1 1 1 Occludin homology domain ELL PF10390.7 NM_025165.2_2 - 6.3e-11 42.2 0.0 1.6e-10 40.8 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase II elongation factor ELL BicD PF09730.7 NM_025165.2_2 - 0.027 12.8 1.2 0.039 12.3 1.2 1.1 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D DUF4477 PF14780.4 NM_001319110.1_1 - 0.00015 21.4 0.6 0.00064 19.3 0.4 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4477) SCAMP PF04144.11 NM_005698.3_1 - 6.2e-68 228.4 15.9 7.9e-68 228.0 15.9 1.1 1 0 0 1 1 1 1 SCAMP family Phage_holin_3_6 PF07332.9 NM_005698.3_1 - 0.79 9.7 9.4 0.086 12.8 3.4 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Mannosyl_trans PF05007.11 NM_145167.2_3 - 1e-106 356.5 27.4 1.8e-106 355.6 27.4 1.4 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.11 NM_145167.2_3 - 4.3e-14 52.2 29.5 9.2e-14 51.2 29.5 1.5 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U CAP_GLY PF01302.23 NM_001287528.1_3 - 5e-48 160.8 2.7 3.3e-23 81.4 0.3 2.3 2 0 0 2 2 2 2 CAP-Gly domain Ank_2 PF12796.5 NM_001287528.1_3 - 6.1e-10 39.4 0.4 4.3e-07 30.3 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001287528.1_3 - 2.8e-07 30.8 0.2 2.1e-05 24.8 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 NM_001287528.1_3 - 2.5e-05 24.4 3.5 0.049 14.0 0.2 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.4 NM_001287528.1_3 - 0.00033 20.8 1.9 0.14 12.4 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001287528.1_3 - 0.00073 19.7 1.4 5.3 7.8 0.1 3.9 4 0 0 4 4 4 2 Ankyrin repeat Tubulin-binding PF00418.17 NM_001287528.1_3 - 0.06 13.2 0.8 0.5 10.3 0.1 2.4 2 0 0 2 2 2 0 Tau and MAP protein, tubulin-binding repeat Ras PF00071.20 NM_001318054.1_2 - 4.8e-53 178.9 0.1 6.6e-53 178.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001318054.1_2 - 3.9e-21 75.4 0.0 6.5e-21 74.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001318054.1_2 - 9e-08 31.6 0.0 1.2e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 NM_001318054.1_2 - 2.3e-05 23.9 0.2 7.1e-05 22.3 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 NM_001318054.1_2 - 0.0001 22.2 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_001318054.1_2 - 0.00017 21.4 0.0 0.53 10.0 0.0 2.4 2 1 0 2 2 2 2 Protein of unknown function, DUF258 FeoB_N PF02421.16 NM_001318054.1_2 - 0.022 14.2 0.0 0.11 11.8 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Gtr1_RagA PF04670.10 NM_001318054.1_2 - 0.042 13.1 0.0 0.054 12.7 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Septin PF00735.16 NM_001318054.1_2 - 0.15 11.2 0.0 0.24 10.5 0.0 1.3 1 1 0 1 1 1 0 Septin ATP_bind_1 PF03029.15 NM_001318054.1_2 - 0.15 11.6 0.3 1.9 8.1 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein zf-H2C2_2 PF13465.4 NM_005773.2_2 - 9.5e-102 329.2 110.0 1.1e-09 38.2 0.5 17.4 17 2 0 17 17 16 15 Zinc-finger double domain zf-C2H2 PF00096.24 NM_005773.2_2 - 1.8e-76 248.4 141.6 2.3e-07 30.8 0.8 16.5 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_005773.2_2 - 8.5e-39 128.7 140.7 0.00073 20.0 2.5 17.0 18 0 0 18 18 17 15 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_005773.2_2 - 8.7e-29 98.8 98.9 0.0061 16.3 0.8 14.9 14 0 0 14 14 14 13 C2H2-type zinc finger KRAB PF01352.25 NM_005773.2_2 - 2.7e-21 74.8 0.3 4.7e-21 74.1 0.3 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_005773.2_2 - 3.2e-10 39.9 69.0 0.3 11.3 0.1 14.6 15 0 0 15 15 14 7 Zinc-finger double-stranded RNA-binding DZR PF12773.5 NM_005773.2_2 - 8.3e-08 32.0 59.2 0.5 10.3 6.8 8.7 2 1 4 6 6 6 4 Double zinc ribbon Zn-ribbon_8 PF09723.8 NM_005773.2_2 - 6.3e-07 29.3 81.5 0.18 11.8 2.6 11.2 5 2 9 14 14 14 9 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_005773.2_2 - 1.6e-06 28.7 53.7 0.5 11.0 0.7 8.2 2 1 12 14 14 13 10 zinc-ribbon family XPA_N PF01286.16 NM_005773.2_2 - 1.5e-05 24.8 78.2 0.64 10.0 0.8 14.4 14 0 0 14 14 14 6 XPA protein N-terminal CpXC PF14353.4 NM_005773.2_2 - 0.02 14.8 50.4 1.7 8.5 0.1 12.9 5 5 4 10 10 10 0 CpXC protein zf-C2H2_11 PF16622.3 NM_005773.2_2 - 0.033 13.8 94.6 0.19 11.4 0.6 14.2 14 0 0 14 14 14 0 zinc-finger C2H2-type C1_4 PF07975.10 NM_005773.2_2 - 0.1 12.7 75.0 0.45 10.7 3.0 10.9 1 1 7 11 11 11 0 TFIIH C1-like domain ADK_lid PF05191.12 NM_005773.2_2 - 0.13 12.2 0.2 0.13 12.2 0.2 10.1 4 3 3 7 7 6 0 Adenylate kinase, active site lid DUF3996 PF13161.4 NM_005773.2_3 - 0.01 15.4 0.1 8.5 6.0 0.0 3.3 2 1 0 3 3 3 0 Protein of unknown function (DUF3996) TFIID_20kDa PF03847.11 NM_005644.3_3 - 1.7e-35 121.2 2.6 2.5e-35 120.6 2.6 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.21 NM_005644.3_3 - 3.9e-05 23.7 0.2 7e-05 22.9 0.2 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.22 NM_005644.3_3 - 0.00012 22.4 0.2 0.00024 21.4 0.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.13 NM_005644.3_3 - 0.00038 20.4 0.2 0.00072 19.5 0.1 1.5 1 1 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.4 NM_005644.3_3 - 0.035 14.1 0.1 0.074 13.0 0.1 1.5 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TAF4 PF05236.12 NM_005644.3_3 - 0.057 13.1 0.1 0.087 12.5 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family zf-RING_UBOX PF13445.4 NM_032588.3_3 - 2e-10 40.4 3.3 6.2e-10 38.8 3.3 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_032588.3_3 - 6.9e-08 32.1 3.4 6.9e-08 32.1 3.4 3.3 3 1 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_032588.3_3 - 7.3e-08 32.0 3.0 7.3e-08 32.0 3.0 3.6 5 0 0 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_032588.3_3 - 4e-07 29.8 4.9 4e-07 29.8 4.9 3.2 4 0 0 4 4 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_032588.3_3 - 2.9e-06 27.3 6.2 2.9e-06 27.3 6.2 3.7 3 2 0 3 3 1 1 Ring finger domain zf-B_box PF00643.22 NM_032588.3_3 - 3e-06 27.2 7.0 3e-06 27.2 7.0 3.7 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4_4 PF15227.4 NM_032588.3_3 - 1.8e-05 24.7 6.5 1.8e-05 24.7 6.5 3.6 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.4 NM_032588.3_3 - 0.0002 21.0 0.2 0.0002 21.0 0.2 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Fzo_mitofusin PF04799.11 NM_032588.3_3 - 0.0081 15.5 4.0 0.013 14.8 4.0 1.4 1 0 0 1 1 1 1 fzo-like conserved region ATP-synt_E_2 PF08112.9 NM_032588.3_3 - 0.0098 16.0 1.1 0.024 14.7 1.1 1.7 1 0 0 1 1 1 1 ATP synthase epsilon subunit YceG_bac PF14266.4 NM_032588.3_3 - 0.019 13.7 1.0 0.028 13.2 1.0 1.1 1 0 0 1 1 1 0 Putative component of 'biosynthetic module' DUF745 PF05335.11 NM_032588.3_3 - 0.042 13.4 4.1 2.5 7.7 2.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF1664 PF07889.10 NM_032588.3_3 - 0.051 13.4 4.5 0.088 12.7 4.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Spt4 PF06093.11 NM_032588.3_3 - 0.13 12.3 0.0 0.13 12.3 0.0 3.2 3 0 0 3 3 3 0 Spt4/RpoE2 zinc finger Phasin PF05597.9 NM_032588.3_3 - 0.14 12.1 3.9 0.28 11.1 3.9 1.5 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) MukF_M PF17192.2 NM_032588.3_3 - 0.74 9.4 6.3 3.5 7.2 6.3 1.9 1 1 0 1 1 1 0 MukF middle domain PfkB PF00294.22 NM_032588.3_3 - 1.5 7.9 3.2 0.86 8.7 1.4 1.4 1 1 0 1 1 1 0 pfkB family carbohydrate kinase DUF349 PF03993.10 NM_032588.3_3 - 2.7 8.2 8.4 1.5 9.1 1.1 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) zf-RING_4 PF14570.4 NM_032588.3_3 - 9.7 5.9 16.7 0.28 10.8 6.6 3.4 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain DAN PF03045.13 NM_005380.7_3 - 4.4e-23 81.3 8.5 6.7e-23 80.7 8.5 1.2 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.20 NM_005380.7_3 - 7.1e-06 26.1 7.9 1.1e-05 25.5 7.9 1.2 1 0 0 1 1 1 1 Cystine-knot domain 7tm_1 PF00001.19 NM_018970.6_1 - 2.7e-30 105.4 9.4 5.7e-30 104.3 9.4 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Peptidase_S8 PF00082.20 NM_003791.3_3 - 5.7e-39 134.0 0.0 7.9e-39 133.5 0.0 1.2 1 0 0 1 1 1 1 Subtilase family RHD_dimer PF16179.3 NM_012340.4_2 - 6.8e-25 87.0 0.4 1.1e-24 86.3 0.4 1.3 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.20 NM_012340.4_2 - 7.1e-22 78.0 0.4 1.3e-21 77.1 0.4 1.5 1 1 0 1 1 1 1 Rel homology DNA-binding domain TIG PF01833.22 NM_012340.4_2 - 2.2e-06 27.5 0.0 4.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 IPT/TIG domain ERCC4 PF02732.13 NM_005236.2_1 - 3.8e-24 85.5 0.0 6.2e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.4 NM_005236.2_1 - 0.018 15.6 0.0 0.042 14.4 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain LUC7 PF03194.13 NM_005236.2_1 - 2.7 7.4 9.0 2 7.8 3.2 2.2 2 0 0 2 2 2 0 LUC7 N_terminus Otopetrin PF03189.11 NM_177998.1_1 - 9.7e-46 156.3 14.9 5.9e-19 68.1 0.9 3.9 2 1 0 3 3 3 3 Otopetrin Mucin15 PF15672.3 NM_177998.1_1 - 0.22 10.8 0.2 0.68 9.2 0.1 1.6 1 1 0 2 2 2 0 Cell-membrane associated Mucin15 Na_Ca_ex PF01699.22 NM_177998.1_1 - 0.39 10.6 10.2 1.5 8.7 1.1 2.9 3 0 0 3 3 3 0 Sodium/calcium exchanger protein DUF5134 PF17197.2 NM_177998.1_1 - 1.1 9.0 9.9 0.6 9.9 1.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5134) Phage_holin_3_6 PF07332.9 NM_177998.1_1 - 1.5 8.8 16.8 0.25 11.3 0.2 2.8 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF1345 PF07077.9 NM_177998.1_1 - 5.9 6.4 11.1 0.69 9.4 0.7 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1345) NBP1 PF08537.8 NM_173618.2_1 - 0.012 14.9 1.3 0.016 14.5 1.3 1.1 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 DegS PF05384.9 NM_173618.2_1 - 0.036 13.4 0.4 0.055 12.8 0.4 1.1 1 0 0 1 1 1 0 Sensor protein DegS ER_lumen_recept PF00810.16 NM_001100603.1_3 - 1.5e-24 87.4 2.1 1.5e-24 87.4 2.1 2.2 2 0 0 2 2 2 1 ER lumen protein retaining receptor TRAPP PF04051.14 NM_001270896.1_1 - 9.7e-36 122.5 0.0 1.3e-35 122.1 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Cadherin PF00028.15 NM_001317228.1_1 - 1.5e-62 207.9 1.9 4.5e-16 58.9 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 NM_001317228.1_1 - 4.7e-54 182.1 0.6 8e-54 181.4 0.6 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.10 NM_001317228.1_1 - 3.2e-05 23.5 0.0 0.025 14.3 0.0 2.6 2 0 0 2 2 2 2 Cadherin-like Rifin_STEVOR PF02009.14 NM_001317228.1_1 - 0.069 12.9 0.4 0.11 12.2 0.4 1.2 1 0 0 1 1 1 0 Rifin/stevor family zf-H2C2_2 PF13465.4 NM_152458.6_2 - 1.6e-34 116.6 37.4 1.2e-06 28.6 0.4 8.8 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_152458.6_2 - 7e-34 114.3 38.5 9.4e-06 25.7 0.7 7.9 7 0 0 7 7 7 7 Zinc finger, C2H2 type KRAB PF01352.25 NM_152458.6_2 - 1e-20 72.9 0.0 1.8e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_152458.6_2 - 7.5e-19 66.7 37.8 0.0057 17.3 0.5 8.3 7 0 0 7 7 7 7 C2H2-type zinc finger zf-LYAR PF08790.9 NM_152458.6_2 - 1e-05 25.2 12.0 11 5.9 0.0 7.3 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.8 NM_152458.6_2 - 3e-05 23.9 27.0 0.089 12.8 2.3 4.8 4 1 0 4 4 4 3 Zinc ribbon domain zf-trcl PF13451.4 NM_152458.6_2 - 0.00049 19.8 7.5 9.2 6.1 0.0 6.4 7 0 0 7 7 7 0 Probable zinc-ribbon domain zf-C2H2_jaz PF12171.6 NM_152458.6_2 - 0.0066 16.6 2.2 0.075 13.2 0.0 3.6 5 0 0 5 5 4 1 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.4 NM_152458.6_2 - 0.089 12.6 10.1 4.3 7.2 0.3 4.0 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-DNA_Pol PF08996.8 NM_152458.6_2 - 0.11 12.1 7.0 0.86 9.2 0.2 3.1 1 1 4 5 5 5 0 DNA Polymerase alpha zinc finger DUF3268 PF11672.6 NM_152458.6_2 - 0.13 12.5 6.6 2.8 8.2 0.2 3.3 3 0 0 3 3 3 0 zinc-finger-containing domain zf-C2H2_6 PF13912.4 NM_152458.6_2 - 0.14 12.0 0.1 0.14 12.0 0.1 6.7 7 0 0 7 7 7 0 C2H2-type zinc finger zf-C2H2_8 PF15909.3 NM_152458.6_2 - 1.2 9.4 17.5 0.12 12.5 1.3 3.6 1 1 2 3 3 3 0 C2H2-type zinc ribbon zf-met PF12874.5 NM_152458.6_2 - 1.5 9.2 17.9 17 5.8 0.0 6.2 6 0 0 6 6 6 0 Zinc-finger of C2H2 type SprT-like PF10263.7 NM_152458.6_2 - 1.6 8.4 20.1 2.8 7.6 0.5 4.2 3 1 0 4 4 4 0 SprT-like family Plasmod_MYXSPDY PF07981.9 NM_152458.6_2 - 2.6 8.1 10.1 0.41 10.7 0.9 3.6 3 0 0 3 3 3 0 Plasmodium repeat_MYXSPDY CpXC PF14353.4 NM_152458.6_2 - 3.9 7.4 15.0 30 4.5 0.0 5.4 3 2 3 6 6 6 0 CpXC protein zf-Di19 PF05605.10 NM_152458.6_2 - 4.7 7.4 19.6 7.6 6.8 0.8 4.6 2 1 3 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding Sema PF01403.17 NM_020858.1_2 - 3.5e-131 437.7 0.2 6.8e-131 436.8 0.0 1.5 2 0 0 2 2 2 1 Sema domain PRT_C PF08372.8 NM_020858.1_2 - 0.3 10.7 1.8 0.77 9.4 1.8 1.7 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal NKAIN PF05640.12 NM_001304533.1_1 - 1.1e-86 289.1 7.4 1.6e-86 288.6 7.4 1.2 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein UQ_con PF00179.24 NM_003348.3_1 - 3e-46 156.4 0.0 4.1e-46 156.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 NM_003348.3_1 - 0.022 14.3 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.11 NM_003348.3_1 - 0.079 12.7 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 UEV domain Forkhead PF00250.16 NM_004473.3_1 - 6.2e-36 122.5 0.0 9.3e-36 121.9 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain Ion_trans PF00520.29 NM_001112741.1_2 - 1.9e-44 151.6 13.8 2.6e-44 151.2 13.8 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_001112741.1_2 - 1.9e-27 95.3 0.0 4.4e-27 94.1 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_001112741.1_2 - 1.1e-10 41.2 2.7 1.1e-10 41.2 2.7 2.5 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.3 NM_001112741.1_2 - 0.0084 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain VHS PF00790.17 NM_001291641.1_1 - 8.9e-46 155.1 0.8 2.2e-45 153.8 0.0 1.9 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.18 NM_001291641.1_1 - 2.5e-27 95.2 0.0 4.3e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.12 NM_001291641.1_1 - 2.6e-18 66.0 2.3 2.6e-18 66.0 2.3 2.3 2 0 0 2 2 2 1 GAT domain HBM PF16591.3 NM_001291641.1_1 - 0.14 11.4 2.2 0.22 10.8 2.2 1.2 1 0 0 1 1 1 0 Helical bimodular sensor domain RapA_C PF12137.6 NM_001291641.1_1 - 0.17 10.7 1.3 0.27 10.1 1.3 1.3 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal CPSase_L_D2 PF02786.15 NM_001127692.2_2 - 3.3e-86 288.0 0.0 5.1e-86 287.4 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.20 NM_001127692.2_2 - 3.2e-46 156.3 0.5 1.1e-45 154.5 0.2 2.0 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.17 NM_001127692.2_2 - 6.2e-36 122.6 0.0 1.4e-35 121.5 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.20 NM_001127692.2_2 - 5.8e-21 74.0 2.2 5.8e-21 74.0 2.2 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.11 NM_001127692.2_2 - 4.1e-10 39.4 0.1 4.7e-09 35.9 0.0 2.2 1 1 1 2 2 2 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.4 NM_001127692.2_2 - 2e-09 36.5 0.1 5.9e-09 34.9 0.1 1.7 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.4 NM_001127692.2_2 - 8.8e-08 31.8 0.1 0.0022 17.7 0.0 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.20 NM_001127692.2_2 - 1.2e-06 28.1 0.0 2.2e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.9 NM_001127692.2_2 - 3.2e-05 23.5 0.0 6.1e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_3 PF13437.4 NM_001127692.2_2 - 0.00064 20.3 0.2 0.036 14.6 0.1 2.6 2 0 0 2 2 2 1 HlyD family secretion protein ATP-grasp_3 PF02655.12 NM_001127692.2_2 - 0.0011 18.9 0.0 0.0029 17.5 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.4 NM_001127692.2_2 - 0.01 15.2 0.0 0.047 13.0 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain HlyD_D23 PF16576.3 NM_001127692.2_2 - 0.011 14.8 0.3 0.44 9.6 0.1 2.4 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion SLT_beta PF02258.14 NM_001127692.2_2 - 0.037 13.9 0.1 0.037 13.9 0.1 3.2 3 1 1 4 4 4 0 Shiga-like toxin beta subunit RnfC_N PF13375.4 NM_001127692.2_2 - 0.048 13.5 0.4 0.19 11.6 0.4 2.0 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain GARS_A PF01071.17 NM_001127692.2_2 - 0.091 12.4 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain PASTA PF03793.17 NM_001127692.2_2 - 0.15 11.8 0.0 1.5 8.6 0.0 2.6 2 0 0 2 2 2 0 PASTA domain SnoaL_3 PF13474.4 NM_001127692.2_2 - 0.16 12.1 0.0 2 8.6 0.0 2.4 1 1 1 2 2 2 0 SnoaL-like domain Glyco_hydro_35 PF01301.17 NM_001286427.1_2 - 4.5e-87 292.5 0.7 2.7e-50 171.6 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.13 NM_001286427.1_2 - 5.3e-09 35.8 0.0 7.6e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.4 NM_001286427.1_2 - 0.0036 17.7 0.6 0.024 15.0 0.1 2.4 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain KRAB PF01352.25 NM_021915.3_3 - 5.1e-13 48.3 0.2 9.3e-13 47.5 0.2 1.4 1 0 0 1 1 1 1 KRAB box KRAB PF01352.25 NM_213597.3_1 - 2.3e-05 23.8 0.6 7e-05 22.3 0.2 2.1 2 0 0 2 2 2 1 KRAB box Macro PF01661.19 NM_001146104.1_3 - 2.5e-48 162.9 0.5 1.5e-30 105.5 0.1 2.4 2 0 0 2 2 2 2 Macro domain PARP PF00644.18 NM_001146104.1_3 - 4.2e-05 23.2 0.1 0.0013 18.3 0.0 2.5 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain GTF2I PF02946.12 NM_016328.2_1 - 8.5e-156 506.2 8.2 5.2e-31 106.4 0.1 5.2 5 0 0 5 5 5 5 GTF2I-like repeat PAP2_C PF14360.4 NM_147156.3_1 - 8.4e-28 96.6 14.6 3.3e-27 94.7 14.6 2.1 1 0 0 1 1 1 1 PAP2 superfamily C-terminal PAP2 PF01569.19 NM_147156.3_1 - 5.4e-07 29.3 6.7 1.2e-06 28.3 6.7 1.5 1 0 0 1 1 1 1 PAP2 superfamily SAM_1 PF00536.28 NM_147156.3_1 - 0.00036 20.8 0.0 0.00072 19.8 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAP2_3 PF14378.4 NM_147156.3_1 - 0.0045 16.6 15.5 0.015 14.9 15.3 1.8 1 1 0 1 1 1 1 PAP2 superfamily SAM_2 PF07647.15 NM_147156.3_1 - 0.038 14.0 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Endosulfine PF04667.15 NM_006628.5_1 - 8.8e-09 35.3 1.4 1.4e-08 34.6 1.4 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Cadherin PF00028.15 NM_203487.2_3 - 1.7e-100 329.6 11.4 3.3e-20 72.2 0.1 7.4 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.9 NM_203487.2_3 - 9.1e-83 277.4 1.0 1.5e-82 276.7 1.0 1.3 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.10 NM_203487.2_3 - 2.1e-18 65.7 0.0 3.2e-08 33.2 0.0 5.8 6 0 0 6 6 6 4 Cadherin-like Cadherin_3 PF16184.3 NM_203487.2_3 - 2e-06 27.7 16.7 0.96 9.3 0.0 5.9 6 0 0 6 6 6 4 Cadherin-like He_PIG PF05345.10 NM_203487.2_3 - 0.0016 18.4 4.0 1.8 8.7 0.0 4.9 4 0 0 4 4 4 1 Putative Ig domain EphA2_TM PF14575.4 NM_203487.2_3 - 0.0077 16.9 0.3 0.027 15.2 0.3 1.9 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain AP3D1 PF06375.9 NM_203487.2_3 - 0.038 14.1 0.4 0.12 12.5 0.4 1.9 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF1510 PF07423.9 NM_203487.2_3 - 0.04 13.2 0.2 0.076 12.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4834 PF16118.3 NM_203487.2_3 - 1.1 10.1 3.7 0.42 11.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Clathrin_lg_ch PF01086.15 NM_007096.3_1 - 9.2e-55 185.9 1.1 1.9e-54 184.9 1.1 1.5 1 1 0 1 1 1 1 Clathrin light chain CENP-Q PF13094.4 NM_007096.3_1 - 0.00031 20.8 1.9 0.00046 20.3 1.9 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit FadA PF09403.8 NM_007096.3_1 - 0.17 12.3 5.0 0.27 11.6 5.0 1.3 1 0 0 1 1 1 0 Adhesion protein FadA IncA PF04156.12 NM_007096.3_1 - 0.67 9.6 3.9 1.4 8.5 3.9 1.5 1 1 0 1 1 1 0 IncA protein CNDH2_C PF16858.3 NM_152299.3_3 - 1.2e-92 310.6 1.0 1.6e-92 310.3 1.0 1.1 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CNDH2_N PF06278.9 NM_152299.3_3 - 5.2e-45 152.1 0.1 9.5e-45 151.3 0.1 1.4 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal CNDH2_M PF16869.3 NM_152299.3_3 - 8.5e-22 78.3 0.5 5.4e-21 75.7 0.5 2.4 1 1 0 1 1 1 1 PF16858 Kinesin PF00225.21 NM_001173465.1_1 - 3.4e-107 358.1 0.7 3.4e-107 358.1 0.7 2.3 2 1 0 3 3 3 1 Kinesin motor domain WD40 PF00400.30 NM_001173465.1_1 - 1.2e-29 101.8 11.3 1.5e-05 25.5 0.3 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat Microtub_bd PF16796.3 NM_001173465.1_1 - 4e-24 85.1 0.0 4e-24 85.1 0.0 2.5 2 0 0 2 2 2 1 Microtubule binding PolyA_pol PF01743.18 NM_001173465.1_1 - 2 8.7 13.3 4.7 7.5 0.0 4.4 3 1 1 4 4 4 0 Poly A polymerase head domain FPN1 PF06963.10 NM_014585.5_1 - 2.3e-192 639.3 13.2 2.8e-192 639.0 13.2 1.1 1 0 0 1 1 1 1 Ferroportin1 (FPN1) DUF347 PF03988.10 NM_014585.5_1 - 9.2 6.4 9.9 0.57 10.3 0.1 3.6 3 1 0 3 3 3 0 Repeat of Unknown Function (DUF347) SH2 PF00017.22 NM_022071.3_3 - 2.9e-13 49.6 0.0 6.7e-13 48.4 0.0 1.7 1 0 0 1 1 1 1 SH2 domain TcpA PF05946.10 NM_022071.3_3 - 0.026 14.5 0.0 0.046 13.7 0.0 1.2 1 0 0 1 1 1 0 Toxin-coregulated pilus subunit TcpA DUF2039 PF10217.7 NM_022071.3_3 - 0.62 10.3 6.1 1.6 9.0 6.1 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) MRAP PF15183.4 NM_001285394.1_3 - 1.4e-26 92.1 0.4 2.2e-26 91.5 0.4 1.3 1 0 0 1 1 1 1 Melanocortin-2 receptor accessory protein family SCHIP-1 PF10148.7 NM_001197108.1_2 - 4.2e-109 363.5 10.2 5.1e-109 363.3 10.2 1.1 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 FEZ PF07763.11 NM_001197108.1_2 - 0.0011 18.6 7.9 0.0019 17.9 7.9 1.3 1 0 0 1 1 1 1 FEZ-like protein DUF5102 PF17104.3 NM_001197108.1_2 - 0.15 12.0 6.6 0.22 11.4 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) MRVI1 PF05781.10 NM_001206880.1_3 - 9.8e-193 641.5 6.4 1.3e-192 641.1 6.4 1.1 1 0 0 1 1 1 1 MRVI1 protein Thioredoxin_6 PF13848.4 NM_019022.3_1 - 7.6e-26 91.1 0.8 1.5e-23 83.6 1.9 2.2 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.18 NM_019022.3_1 - 2.2e-24 85.3 0.0 8.6e-24 83.3 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Calsequestrin PF01216.15 NM_019022.3_1 - 0.0017 17.3 0.5 0.0032 16.4 0.4 1.5 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_2 PF13098.4 NM_019022.3_1 - 0.002 18.4 0.0 0.0094 16.3 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain BNIP3 PF06553.10 NM_001301409.1_1 - 1.8e-12 47.2 5.8 3.2e-12 46.4 5.8 1.3 1 0 0 1 1 1 1 BNIP3 Gal_mutarotas_2 PF13802.4 NM_001301409.1_3 - 1.1e-18 67.1 0.2 2e-18 66.4 0.2 1.4 1 0 0 1 1 1 1 Galactose mutarotase-like BNIP3 PF06553.10 NM_001301409.1_3 - 0.00053 19.6 0.1 0.00095 18.8 0.1 1.3 1 0 0 1 1 1 1 BNIP3 Epimerase_2 PF02350.17 NM_001190383.1_3 - 3.8e-66 223.2 0.1 5.5e-66 222.7 0.1 1.2 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase ROK PF00480.18 NM_001190383.1_3 - 3.3e-31 108.7 2.3 4.1e-28 98.6 1.2 2.2 1 1 1 2 2 2 2 ROK family DRTGG PF07085.10 NM_001190383.1_3 - 0.0064 16.1 0.2 0.015 14.9 0.2 1.5 1 0 0 1 1 1 1 DRTGG domain FGGY_N PF00370.19 NM_001190383.1_3 - 0.012 15.1 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Hexokinase_1 PF00349.19 NM_001190383.1_3 - 0.019 14.8 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Hexokinase Ig_3 PF13927.4 NM_001102600.2_2 - 8.2e-41 138.4 3.6 4e-09 36.8 0.1 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 NM_001102600.2_2 - 4.1e-35 119.8 2.1 6.5e-08 32.7 0.0 4.9 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 NM_001102600.2_2 - 2.4e-31 107.5 0.1 7.4e-09 35.4 0.0 5.5 4 2 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.23 NM_001102600.2_2 - 6.3e-23 80.6 7.9 3.8e-05 23.7 0.3 5.1 4 2 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 NM_001102600.2_2 - 1.6e-13 50.6 5.6 0.15 12.1 0.0 6.5 4 3 2 6 6 6 4 Immunoglobulin V-set domain Ig_4 PF16680.3 NM_001102600.2_2 - 5.2e-07 29.8 0.0 0.35 11.1 0.0 4.5 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 NM_001102600.2_2 - 4.8e-06 26.4 0.0 1.8 8.5 0.0 4.4 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain C2-set PF05790.13 NM_001102600.2_2 - 0.00011 22.2 0.0 0.34 11.0 0.0 4.8 4 1 1 5 5 5 1 Immunoglobulin C2-set domain Adeno_E3_CR1 PF02440.13 NM_001102600.2_2 - 0.027 14.1 0.2 6.6 6.5 0.0 3.7 4 0 0 4 4 4 0 Adenovirus E3 region protein CR1 DUF3244 PF11589.6 NM_001102600.2_2 - 0.03 14.3 0.0 0.091 12.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3244) VSP PF03302.11 NM_001102600.2_2 - 0.14 10.8 0.8 0.21 10.3 0.8 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein C_Hendra PF16821.3 NM_001102600.2_2 - 0.16 11.7 0.4 0.33 10.7 0.4 1.4 1 0 0 1 1 1 0 C protein from hendra and measles viruses C2-set_2 PF08205.10 NM_001102600.2_2 - 0.69 9.9 4.5 0.8 9.7 0.0 3.2 4 0 0 4 4 4 0 CD80-like C2-set immunoglobulin domain ApoL PF05461.9 NM_145639.1_1 - 1.5e-133 444.9 5.2 1.8e-133 444.7 5.2 1.1 1 0 0 1 1 1 1 Apolipoprotein L DUF3150 PF11348.6 NM_145639.1_1 - 0.0076 15.4 0.4 0.03 13.5 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3150) SseC PF04888.10 NM_145639.1_1 - 0.019 14.3 3.5 0.026 13.9 1.8 1.8 1 1 1 2 2 2 0 Secretion system effector C (SseC) like family TBCA PF02970.14 NM_145639.1_1 - 0.05 13.8 5.2 0.058 13.6 1.5 2.2 2 0 0 2 2 2 0 Tubulin binding cofactor A Transposase_mut PF00872.16 NM_145639.1_1 - 0.053 12.2 0.2 0.09 11.5 0.2 1.2 1 0 0 1 1 1 0 Transposase, Mutator family Vir_act_alpha_C PF10400.7 NM_145639.1_1 - 0.28 11.8 3.1 0.52 10.9 0.0 2.7 2 1 0 2 2 2 0 Virulence activator alpha C-term Elongin_A PF06881.9 NM_058229.3_3 - 0.0013 19.1 0.1 0.0033 17.8 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A DARPP-32 PF05395.10 NM_032192.3_2 - 1.2e-61 207.5 14.4 1.2e-61 207.5 14.4 2.2 2 0 0 2 2 2 1 Protein phosphatase inhibitor 1/DARPP-32 DNA_pol_phi PF04931.11 NM_032192.3_2 - 3.7 5.4 11.9 5.7 4.8 11.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi Zip PF02535.20 NM_001280557.1_1 - 3.6e-43 147.9 1.9 4.3e-43 147.7 1.9 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Actin PF00022.17 NM_001320855.1_1 - 3.6e-149 496.7 0.0 9.8e-149 495.3 0.0 1.6 1 1 0 1 1 1 1 Actin Period_C PF12114.6 NM_022817.2_1 - 3.9e-87 290.7 1.6 3.9e-87 290.7 1.6 3.3 3 0 0 3 3 3 1 Period protein 2/3C-terminal region PAS_3 PF08447.10 NM_022817.2_1 - 8.7e-12 45.0 0.0 2.8e-11 43.4 0.0 1.8 2 0 0 2 2 2 1 PAS fold PAS PF00989.23 NM_022817.2_1 - 4.9e-07 29.6 0.0 0.00015 21.6 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 NM_022817.2_1 - 1.1e-06 28.6 0.0 2.8e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 PAS domain Arf PF00025.19 NM_144996.3_1 - 0.0035 16.7 0.0 0.0064 15.8 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF4414 PF14377.4 NM_144996.3_1 - 0.093 12.9 4.5 0.22 11.7 4.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4414) Ion_trans PF00520.29 NM_001128839.2_2 - 5.4e-257 847.7 87.2 2.1e-71 239.9 18.1 4.1 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 NM_001128839.2_2 - 1.2e-69 235.7 3.5 1.2e-69 235.7 3.5 2.3 2 0 0 2 2 2 1 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 NM_001128839.2_2 - 6.7e-36 121.8 0.0 1.7e-35 120.5 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 NM_001128839.2_2 - 1.2e-30 105.4 0.1 2.8e-30 104.3 0.1 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 NM_001128839.2_2 - 5.3e-09 35.1 81.0 1.4e-07 30.5 3.4 9.2 7 3 2 9 9 9 5 Polycystin cation channel PMP22_Claudin PF00822.18 NM_001306.3_3 - 8.4e-33 113.5 8.8 1.1e-32 113.1 8.8 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001306.3_3 - 2.7e-07 30.4 13.4 1e-06 28.5 13.4 1.8 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction TMEM37 PF15108.4 NM_001306.3_3 - 0.027 14.2 7.6 0.04 13.6 7.6 1.2 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family DUF4064 PF13273.4 NM_001306.3_3 - 0.077 13.2 5.3 0.32 11.2 5.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) SelP_N PF04592.12 NM_001306.3_3 - 0.2 10.9 3.3 0.31 10.3 3.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Amastin PF07344.9 NM_001306.3_3 - 1.8 8.2 9.9 1.7 8.3 7.9 1.9 1 1 1 2 2 2 0 Amastin surface glycoprotein Serpin PF00079.18 NM_000029.3_2 - 2.6e-55 188.1 0.0 3.6e-55 187.6 0.0 1.2 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Nuc_rec_co-act PF08815.8 NM_000029.3_2 - 0.093 12.5 0.6 0.25 11.2 0.2 1.9 2 0 0 2 2 2 0 Nuclear receptor coactivator UPF0054 PF02130.15 NM_001314023.1_2 - 2.9e-15 56.1 0.0 3.7e-15 55.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 Nuc_N PF14448.4 NM_001314023.1_2 - 0.1 12.5 0.1 0.26 11.2 0.0 1.7 2 0 0 2 2 2 0 Nuclease N terminal EF-hand_7 PF13499.4 NM_006569.5_3 - 2.1e-07 31.2 0.0 3.6e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_006569.5_3 - 7.3e-07 28.5 0.0 0.00065 19.3 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 NM_006569.5_3 - 4.1e-05 22.7 0.0 0.3 10.6 0.0 2.8 3 0 0 3 3 3 2 EF hand zf-LITAF-like PF10601.7 NM_001199056.1_3 - 1e-21 76.8 13.9 1e-21 76.8 13.9 3.2 4 0 0 4 4 4 1 LITAF-like zinc ribbon domain Ran_BP1 PF00638.16 NM_001323280.1_1 - 2.8e-12 46.8 0.0 4.9e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain Ldl_recept_a PF00057.16 NM_016579.3_1 - 1.8e-21 75.9 29.0 6.2e-12 45.4 7.6 3.4 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A DUF3678 PF12435.6 NM_016579.3_1 - 0.11 11.7 1.4 0.51 9.5 1.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3678) zf-RING_9 PF13901.4 NM_001286764.1_1 - 1e-66 224.7 17.5 1e-66 224.7 17.5 2.0 2 0 0 2 2 2 1 Putative zinc-RING and/or ribbon Pkinase PF00069.23 NM_139013.2_2 - 7.2e-58 195.9 0.0 9.4e-58 195.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_139013.2_2 - 2.3e-30 105.6 0.0 3.1e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_139013.2_2 - 0.00011 21.6 0.4 0.00016 21.0 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_139013.2_2 - 0.015 15.1 0.1 0.046 13.5 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_139013.2_2 - 0.12 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like DUF3682 PF12446.6 NM_139013.2_3 - 2.2 8.6 6.0 4.3 7.7 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Fibrinogen_C PF00147.16 NM_001039667.2_1 - 4.2e-46 157.4 0.2 6.1e-46 156.9 0.2 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain IncA PF04156.12 NM_001039667.2_1 - 0.0014 18.3 2.0 0.0031 17.2 2.0 1.6 1 0 0 1 1 1 1 IncA protein SlyX PF04102.10 NM_001039667.2_1 - 0.014 15.8 6.7 0.024 15.1 4.5 2.1 2 0 0 2 2 2 0 SlyX Spc7 PF08317.9 NM_001039667.2_1 - 0.024 13.4 0.6 0.036 12.8 0.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein HeLo PF14479.4 NM_001039667.2_1 - 0.026 14.2 0.5 0.04 13.6 0.5 1.2 1 0 0 1 1 1 0 Prion-inhibition and propagation HDV_ag PF01517.16 NM_001039667.2_1 - 0.074 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen Exonuc_VII_L PF02601.13 NM_001039667.2_1 - 0.12 11.8 0.5 0.16 11.4 0.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DivIC PF04977.13 NM_001039667.2_1 - 0.12 12.1 2.6 0.29 10.8 2.6 1.6 1 0 0 1 1 1 0 Septum formation initiator Atg14 PF10186.7 NM_001039667.2_1 - 0.18 10.7 3.0 0.27 10.2 3.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HemX PF04375.12 NM_001039667.2_1 - 0.35 10.0 3.7 0.54 9.4 3.7 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Helo_like_N PF17111.3 NM_001039667.2_1 - 0.51 9.5 2.1 0.97 8.6 0.0 2.0 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins GSHPx PF00255.17 NM_002083.3_3 - 5.2e-40 135.3 0.1 7.2e-40 134.8 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Abhydrolase_1 PF00561.18 NM_007011.7_1 - 7.9e-27 94.4 0.0 1.1e-26 93.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 NM_007011.7_1 - 2.9e-07 29.9 0.0 5.4e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF915 PF06028.9 NM_007011.7_1 - 0.018 14.3 0.0 0.027 13.7 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Ndr PF03096.12 NM_007011.7_1 - 0.02 13.5 0.0 0.031 12.9 0.0 1.1 1 0 0 1 1 1 0 Ndr family Pkinase PF00069.23 NM_001256689.1_3 - 2.4e-62 210.6 0.0 3.8e-62 209.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001256689.1_3 - 6.5e-34 117.3 0.0 1.1e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 NM_001256689.1_3 - 2.2e-14 52.8 0.2 5e-14 51.7 0.2 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.4 NM_001256689.1_3 - 4.1e-09 36.0 0.0 6e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001256689.1_3 - 1.3e-05 24.5 0.1 3.1e-05 23.3 0.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001256689.1_3 - 0.0022 17.8 0.4 0.081 12.7 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.18 NM_001256689.1_3 - 0.057 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF4392 PF14336.4 NM_001102366.2_1 - 4.1e-123 410.3 0.0 5.2e-123 410.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF1445 PF07286.10 NM_001102366.2_1 - 4.5e-44 149.7 0.0 7.1e-44 149.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) 7tm_4 PF13853.4 NM_001005226.2_3 - 9e-45 153.4 15.1 1.2e-44 153.0 15.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005226.2_3 - 2.9e-27 95.4 15.3 5.8e-27 94.5 15.3 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001005226.2_3 - 1.2e-05 24.7 17.9 2.3e-05 23.8 17.9 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx WD40 PF00400.30 NM_007178.3_1 - 5.6e-33 112.3 0.2 1.3e-09 38.4 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_007178.3_1 - 5.9e-06 26.4 0.0 0.6 10.3 0.0 4.7 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 NM_007178.3_1 - 0.043 12.6 0.0 0.4 9.5 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Recep_L_domain PF01030.22 NM_001005915.1_2 - 1.1e-18 67.2 0.0 1.7e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Receptor L domain LIM PF00412.20 NM_001193485.2_3 - 3.7e-60 199.9 59.7 9.3e-14 51.3 3.0 5.5 5 0 0 5 5 5 5 LIM domain JmjC PF02373.20 NM_001291418.1_3 - 5.3e-33 113.7 1.0 5.3e-33 113.7 1.0 2.2 2 0 0 2 2 2 1 JmjC domain, hydroxylase TPR_1 PF00515.26 NM_001291418.1_3 - 1.4e-28 97.4 15.3 1.1e-05 24.9 0.0 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001291418.1_3 - 1.1e-17 62.5 14.7 0.0097 15.8 0.1 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001291418.1_3 - 2.2e-14 53.7 1.8 0.0036 17.8 0.6 5.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001291418.1_3 - 4e-14 51.4 13.6 0.0043 17.0 0.4 7.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001291418.1_3 - 2.4e-11 43.1 4.1 0.0068 16.6 0.0 4.7 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001291418.1_3 - 8.2e-11 41.9 7.8 0.086 13.0 0.2 4.9 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001291418.1_3 - 4.8e-09 36.5 5.6 0.05 14.0 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001291418.1_3 - 2.1e-06 27.9 2.3 2.2 9.2 0.0 5.5 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001291418.1_3 - 2.5e-06 27.0 8.4 1.1 9.3 0.3 6.5 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001291418.1_3 - 7.3e-06 25.9 2.0 0.011 15.7 0.1 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001291418.1_3 - 5e-05 22.8 9.0 0.12 12.0 0.0 6.4 4 2 3 7 7 7 1 TPR repeat TPR_15 PF13429.4 NM_001291418.1_3 - 0.077 12.1 8.1 0.073 12.1 4.1 2.6 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001291418.1_3 - 0.23 12.0 12.1 3.3 8.4 0.1 6.8 8 1 0 8 8 7 0 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001291418.1_3 - 0.8 9.8 0.0 0.8 9.8 0.0 4.2 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.4 NM_001291418.1_3 - 1.6 7.9 11.5 9.1 5.5 0.4 3.2 2 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP 7tm_4 PF13853.4 NM_001005221.2_1 - 3.8e-43 148.1 14.2 4.6e-43 147.8 14.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005221.2_1 - 4.1e-22 78.5 14.2 7.1e-22 77.8 14.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001005221.2_1 - 0.00032 20.0 16.3 0.00078 18.8 16.3 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF456 PF04306.11 NM_001005221.2_1 - 0.093 12.9 0.1 0.093 12.9 0.1 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF456) F-box PF00646.31 NM_033484.2_3 - 1.4e-07 31.1 0.3 3.8e-07 29.7 0.3 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 NM_033484.2_3 - 4.4e-07 29.6 1.5 9.4e-07 28.5 1.5 1.6 1 0 0 1 1 1 1 F-box-like Elongin_A PF06881.9 NM_033484.2_3 - 0.095 13.1 0.1 15 6.0 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF108 PF01958.16 NM_001114598.1_3 - 9.2e-23 80.3 0.0 1.7e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF108 NAD_binding_3 PF03447.14 NM_001114598.1_3 - 7.4e-19 68.4 0.0 1.3e-18 67.7 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.15 NM_001114598.1_3 - 0.005 17.3 0.0 0.009 16.4 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent eIF-3c_N PF05470.10 NM_001317856.1_2 - 7.8e-273 906.1 37.0 5.9e-271 899.9 37.0 2.1 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.25 NM_001317856.1_2 - 5.7e-17 62.0 0.1 1.7e-16 60.5 0.1 1.9 1 0 0 1 1 1 1 PCI domain DUF4674 PF15719.3 NM_001317856.1_2 - 2.7 7.8 9.1 7.3 6.4 9.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) LAM_C PF12544.6 NM_001317856.1_2 - 6.2 6.9 9.8 0.24 11.5 2.8 2.2 1 1 1 2 2 2 0 Lysine-2,3-aminomutase TPR_2 PF07719.15 NM_020458.3_3 - 6.2e-18 63.3 11.0 0.00016 21.4 0.0 9.7 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_020458.3_3 - 1.9e-14 52.6 7.5 0.00052 19.6 0.0 8.2 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_020458.3_3 - 1e-13 50.2 11.8 0.002 18.1 0.0 9.0 11 0 0 11 11 10 3 Tetratricopeptide repeat TPR_11 PF13414.4 NM_020458.3_3 - 2.8e-13 49.2 1.9 0.0012 18.4 0.0 5.4 7 0 0 7 7 7 3 TPR repeat TPR_17 PF13431.4 NM_020458.3_3 - 5.2e-10 38.9 0.0 1.2 9.5 0.0 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_020458.3_3 - 7.5e-10 38.7 27.3 0.12 13.1 0.1 10.0 5 2 5 10 10 9 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_020458.3_3 - 8.6e-10 38.6 18.5 0.0014 18.7 0.0 7.0 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_16 PF13432.4 NM_020458.3_3 - 4.8e-09 36.6 22.6 0.022 15.3 0.0 6.4 5 1 0 6 6 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_020458.3_3 - 1.7e-08 34.7 18.5 0.022 15.1 0.0 7.3 7 2 1 9 9 8 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_020458.3_3 - 3.6e-07 30.1 10.6 0.31 11.1 4.2 5.2 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.4 NM_020458.3_3 - 1.1e-05 24.6 4.2 0.0045 16.1 0.2 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_020458.3_3 - 6.6e-05 23.2 7.8 1.7 9.3 0.0 7.5 8 0 0 8 8 7 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_020458.3_3 - 0.0001 22.3 14.1 0.25 11.4 1.4 5.3 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.6 NM_020458.3_3 - 0.00039 19.3 0.2 0.45 9.2 0.0 2.3 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 DUF3808 PF10300.7 NM_020458.3_3 - 0.003 16.2 0.1 0.0064 15.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_7 PF13176.4 NM_020458.3_3 - 0.0057 16.5 6.3 2 8.5 0.0 5.6 7 0 0 7 7 5 1 Tetratricopeptide repeat ChAPs PF09295.8 NM_020458.3_3 - 0.07 12.0 5.5 1.3 7.9 1.9 2.8 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.4 NM_020458.3_3 - 0.12 12.5 17.8 0.14 12.4 1.3 4.8 5 1 1 6 6 4 0 Tetratricopeptide repeat MIT PF04212.16 NM_020458.3_3 - 0.41 10.6 7.2 5.5 7.0 0.1 3.9 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain DNA_mis_repair PF01119.17 NM_001321046.1_2 - 8.7e-27 93.0 0.4 2.1e-26 91.8 0.0 1.9 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HMG_box PF00505.17 NM_001321046.1_2 - 4.1e-14 52.6 1.7 4.1e-14 52.6 1.7 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_001321046.1_2 - 1.4e-10 41.5 0.7 1.4e-10 41.5 0.7 1.9 2 0 0 2 2 2 1 HMG-box domain HATPase_c_3 PF13589.4 NM_001321046.1_2 - 0.0037 17.0 0.4 0.019 14.6 0.1 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MRP-L46 PF11788.6 NM_001321046.1_2 - 0.23 12.1 7.5 0.72 10.5 7.5 1.8 1 0 0 1 1 1 0 39S mitochondrial ribosomal protein L46 T-box_assoc PF16176.3 NM_006593.3_3 - 7.4e-89 297.5 0.5 1.1e-88 297.0 0.5 1.3 1 0 0 1 1 1 1 T-box transcription factor-associated T-box PF00907.20 NM_006593.3_3 - 1.4e-76 256.7 0.0 1.9e-76 256.3 0.0 1.2 1 0 0 1 1 1 1 T-box Septin PF00735.16 NM_001098813.1_3 - 3.7e-97 324.8 1.3 3.7e-97 324.8 1.3 1.4 2 0 0 2 2 1 1 Septin MMR_HSR1 PF01926.21 NM_001098813.1_3 - 5.3e-06 26.4 0.0 1.1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_001098813.1_3 - 0.00063 19.6 0.1 0.012 15.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_22 PF13401.4 NM_001098813.1_3 - 0.0011 19.1 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Roc PF08477.11 NM_001098813.1_3 - 0.0017 18.4 0.0 0.0033 17.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_001098813.1_3 - 0.0035 17.6 0.0 0.0083 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.25 NM_001098813.1_3 - 0.032 13.6 6.6 7.6 5.9 1.1 3.1 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Ras PF00071.20 NM_001098813.1_3 - 0.061 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Ras family AAA_23 PF13476.4 NM_001098813.1_3 - 0.08 13.3 13.0 4.4 7.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.25 NM_001098813.1_3 - 0.085 13.2 0.7 0.2 12.1 0.0 1.9 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.20 NM_001098813.1_3 - 0.11 12.7 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AIG1 PF04548.14 NM_001098813.1_3 - 0.16 11.1 0.0 0.16 11.1 0.0 2.1 2 0 0 2 2 2 0 AIG1 family IMD PF08397.9 NM_001098813.1_3 - 0.62 9.3 13.4 0.99 8.6 13.4 1.2 1 0 0 1 1 1 0 IRSp53/MIM homology domain Atg14 PF10186.7 NM_001098813.1_3 - 0.84 8.5 12.8 1.4 7.8 12.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_32 PF13654.4 NM_001098813.1_3 - 0.93 8.1 15.4 8.4 4.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain A_deamin PF02137.16 NM_001324445.1_1 - 3.2e-121 404.6 0.0 4.3e-121 404.2 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain HLH PF00010.24 NM_001287347.2_1 - 3.1e-15 55.7 0.2 4.9e-15 55.1 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.3 NM_001287347.2_1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain Ceramidase PF05875.10 NM_020155.3_2 - 0.63 9.3 4.7 1 8.6 4.7 1.3 1 0 0 1 1 1 0 Ceramidase RhoGEF PF00621.18 NM_025014.1_2 - 4.3e-32 111.7 0.1 6e-32 111.2 0.1 1.2 1 0 0 1 1 1 1 RhoGEF domain ubiquitin PF00240.21 NM_001321293.1_2 - 2.2e-05 23.9 0.4 2.2e-05 23.9 0.4 2.3 3 0 0 3 3 3 1 Ubiquitin family Rad60-SLD PF11976.6 NM_001321293.1_2 - 0.016 14.9 0.0 0.04 13.6 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF4041 PF13250.4 NM_001321293.1_2 - 0.016 14.9 0.0 0.072 12.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4041) DUF3664 PF12406.6 NM_001321293.1_2 - 1.3 9.5 11.6 0.36 11.3 7.6 2.0 1 1 1 2 2 2 0 Surface protein GDPD PF03009.15 NM_001171193.1_2 - 4.5e-23 82.2 0.0 2.7e-22 79.6 0.0 1.9 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.4 NM_001171193.1_2 - 0.00032 21.0 0.1 0.00085 19.6 0.1 1.8 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ig_2 PF13895.4 NM_001081442.2_2 - 1.7e-30 105.0 0.8 2.8e-14 53.1 0.0 4.7 5 0 0 5 5 5 4 Immunoglobulin domain Ig_3 PF13927.4 NM_001081442.2_2 - 3.7e-19 69.0 0.4 4e-05 24.0 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 NM_001081442.2_2 - 8.6e-16 57.8 0.0 0.00012 22.0 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 NM_001081442.2_2 - 0.0024 17.9 2.9 18 5.4 0.4 5.4 4 2 1 5 5 5 1 Immunoglobulin V-set domain LEM PF03020.13 NM_001081442.2_2 - 0.04 13.3 1.7 10 5.6 0.1 4.1 4 0 0 4 4 4 0 LEM domain I-set PF07679.14 NM_001081442.2_2 - 0.17 11.8 0.0 70 3.4 0.0 3.5 3 0 0 3 3 3 0 Immunoglobulin I-set domain Papilin_u7 PF16626.3 NM_173462.3_1 - 1.9e-43 146.8 21.4 1.9e-43 146.8 21.4 3.2 2 0 0 2 2 2 1 Linking region between Kunitz_BPTI and I-set on papilin I-set PF07679.14 NM_173462.3_1 - 4.2e-41 138.8 0.0 1.1e-14 54.1 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_173462.3_1 - 1.2e-39 134.7 0.0 2.1e-14 53.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain TSP_1 PF00090.17 NM_173462.3_1 - 5.1e-31 106.5 65.0 7e-10 38.8 12.7 6.3 5 0 0 5 5 5 5 Thrombospondin type 1 domain Ig_2 PF13895.4 NM_173462.3_1 - 3.1e-30 104.2 0.0 2.2e-10 40.6 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_173462.3_1 - 1.5e-26 92.2 0.0 1.9e-09 37.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_173462.3_1 - 2.5e-22 79.0 0.5 0.00087 19.3 0.0 6.2 3 3 1 4 4 4 4 Immunoglobulin V-set domain ADAM_spacer1 PF05986.12 NM_173462.3_1 - 3.7e-19 68.7 0.0 5.9e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Kunitz_BPTI PF00014.21 NM_173462.3_1 - 1.4e-17 63.5 7.7 6.8e-17 61.3 7.7 2.4 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain PLAC PF08686.9 NM_173462.3_1 - 1.1e-10 41.9 7.1 1.1e-10 41.9 7.1 2.7 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain Ig_5 PF16681.3 NM_173462.3_1 - 4.1e-08 33.4 0.0 0.25 11.7 0.0 3.5 3 0 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 NM_173462.3_1 - 3e-07 30.3 0.0 0.0063 16.4 0.0 3.7 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_173462.3_1 - 1.5e-05 25.2 0.0 0.48 10.8 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin C1-set domain SHR-BD PF06650.10 NM_015378.3_3 - 6e-85 284.8 0.0 1e-82 277.5 0.0 3.1 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13 PF16908.3 NM_015378.3_3 - 2.7e-55 187.6 2.6 1.3e-53 182.1 2.3 3.3 3 0 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.3 NM_015378.3_3 - 1.6e-42 145.4 5.3 1.5e-31 109.6 0.0 7.9 6 2 0 6 6 6 3 Repeating coiled region of VPS13 Chorein_N PF12624.5 NM_015378.3_3 - 1.2e-32 112.4 0.3 4.8e-32 110.4 0.3 2.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.3 NM_015378.3_3 - 5e-23 81.6 7.7 1.1e-20 74.0 0.6 3.6 2 1 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal UBA PF00627.29 NM_015378.3_3 - 8.1e-06 25.5 0.0 1.6e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Apt1 PF10351.7 NM_015378.3_3 - 0.062 12.0 1.1 0.13 10.9 0.1 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain PALP PF00291.23 NM_006843.2_3 - 3e-72 243.4 0.7 4e-72 243.0 0.7 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme FAM222A PF15258.4 NM_001288636.1_1 - 9.4e-225 747.6 29.8 1.2e-224 747.2 29.8 1.1 1 0 0 1 1 1 1 Protein family of FAM222A DUF2981 PF11200.6 NM_001288636.1_1 - 3.8 6.5 7.5 4.3 6.3 5.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2981) TGT PF01702.16 NM_001256837.1_1 - 1.4e-65 221.1 0.0 2e-65 220.6 0.0 1.2 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase TSC22 PF01166.16 NM_030935.4_3 - 1.8e-27 95.3 0.4 2.7e-27 94.7 0.4 1.2 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.11 NM_030935.4_3 - 0.017 15.6 0.4 0.029 14.9 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) ZapB PF06005.10 NM_030935.4_3 - 0.022 15.1 0.6 0.042 14.2 0.6 1.3 1 0 0 1 1 1 0 Cell division protein ZapB K-box PF01486.15 NM_030935.4_3 - 0.029 14.4 0.2 0.046 13.8 0.2 1.2 1 0 0 1 1 1 0 K-box region DivIC PF04977.13 NM_030935.4_3 - 0.042 13.5 0.6 0.074 12.7 0.6 1.3 1 0 0 1 1 1 0 Septum formation initiator Acetyltransf_1 PF00583.23 NM_001300800.1_1 - 6.8e-05 22.9 0.0 0.00012 22.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.8 NM_001300800.1_1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein E1-E2_ATPase PF00122.18 NM_174956.2_3 - 7.5e-65 218.2 1.2 7.5e-65 218.2 1.2 2.2 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 NM_174956.2_3 - 3.8e-46 157.0 4.5 7.2e-46 156.0 4.5 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 NM_174956.2_3 - 1.3e-20 73.2 0.1 2.1e-20 72.5 0.1 1.3 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 NM_174956.2_3 - 9.6e-20 71.6 0.2 1.2e-18 68.0 0.2 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 NM_174956.2_3 - 4.4e-18 64.6 0.9 7.5e-18 63.8 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 NM_174956.2_3 - 3.2e-06 26.9 1.1 3.2e-06 26.9 1.1 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 NM_174956.2_3 - 0.001 19.4 0.1 0.003 17.9 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3106 PF11304.6 NM_174956.2_3 - 0.023 15.0 0.0 0.16 12.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) zf-C4 PF00105.16 NM_005036.4_3 - 6.4e-27 93.7 16.1 6.4e-27 93.7 16.1 2.3 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_005036.4_3 - 1.1e-12 47.9 0.1 1.9e-12 47.1 0.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor AMP-binding PF00501.26 NM_001286672.1_1 - 3.1e-50 170.9 0.0 4.4e-50 170.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.23 NM_001286672.1_1 - 1.8e-06 28.1 0.1 3.8e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.4 NM_001286672.1_1 - 0.00014 22.7 0.0 0.00048 20.9 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain PQQ PF01011.19 NM_001286672.1_1 - 0.0086 15.8 0.0 0.068 13.0 0.0 2.4 2 0 0 2 2 2 1 PQQ enzyme repeat PQQ_2 PF13360.4 NM_001286672.1_1 - 0.031 13.7 0.0 0.16 11.4 0.0 2.0 2 0 0 2 2 2 0 PQQ-like domain Flavodoxin_2 PF02525.15 NM_001025433.1_3 - 7.6e-35 120.3 0.1 2.8e-32 111.9 0.2 2.1 1 1 1 2 2 2 2 Flavodoxin-like fold FMN_red PF03358.13 NM_001025433.1_3 - 3e-06 26.9 0.0 4.7e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase PWWP PF00855.15 NM_133335.3_2 - 1.1e-40 137.8 8.2 5.4e-21 74.7 0.7 3.1 3 0 0 3 3 3 2 PWWP domain SET PF00856.26 NM_133335.3_2 - 3.1e-21 76.4 0.3 3.1e-21 76.4 0.3 2.6 2 1 0 2 2 2 1 SET domain PHD PF00628.27 NM_133335.3_2 - 6.6e-11 41.8 70.6 2.9e-06 26.9 9.6 6.6 4 2 2 6 6 6 4 PHD-finger HMG_box PF00505.17 NM_133335.3_2 - 1.9e-09 37.7 0.0 4.5e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_133335.3_2 - 0.00035 21.0 0.0 0.00093 19.6 0.0 1.6 1 0 0 1 1 1 1 HMG-box domain zf-HC5HC2H PF13771.4 NM_133335.3_2 - 0.21 11.7 65.3 0.11 12.7 0.7 6.8 4 2 2 6 6 6 0 PHD-like zinc-binding domain CFC PF09443.8 NM_003212.3_1 - 1e-15 57.1 10.2 3.9e-15 55.3 10.2 2.1 1 0 0 1 1 1 1 Cripto_Frl-1_Cryptic (CFC) EGF_2 PF07974.11 NM_003212.3_1 - 1.5 9.1 16.0 0.059 13.6 7.8 2.8 2 0 0 2 2 2 0 EGF-like domain G-alpha PF00503.18 NM_138736.2_1 - 2.9e-121 404.8 2.4 3.6e-121 404.5 2.4 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 NM_138736.2_1 - 3.4e-15 55.8 0.3 1.5e-11 44.0 0.1 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_138736.2_1 - 0.0003 20.1 0.5 0.014 14.6 0.1 2.1 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 NM_138736.2_1 - 0.033 14.3 0.4 10 6.2 0.1 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase 14-3-3 PF00244.18 NM_012479.3_2 - 6.8e-105 349.3 10.7 8.5e-105 349.0 10.7 1.1 1 0 0 1 1 1 1 14-3-3 protein IPP-2 PF04979.12 NM_006241.7_2 - 2.2e-40 138.3 7.3 3.5e-40 137.6 7.3 1.3 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) FAM163 PF15069.4 NM_001080515.2_3 - 1.9e-61 207.1 0.0 2.4e-61 206.8 0.0 1.1 1 0 0 1 1 1 1 FAM163 family DUF4006 PF13179.4 NM_001080515.2_3 - 0.039 13.7 1.3 0.069 12.9 1.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF4006) Tropomyosin PF00261.18 NM_001043352.1_2 - 1.2e-84 283.2 59.8 1.6e-84 282.9 59.8 1.1 1 0 0 1 1 1 1 Tropomyosin Tropomyosin_1 PF12718.5 NM_001043352.1_2 - 1.7e-21 76.7 56.4 1.8e-18 66.9 28.4 3.1 1 1 2 3 3 3 3 Tropomyosin like Laminin_II PF06009.10 NM_001043352.1_2 - 0.0029 17.5 3.7 0.0029 17.5 3.7 3.2 1 1 1 3 3 3 2 Laminin Domain II P2X_receptor PF00864.17 NM_001256796.1_2 - 1.6e-168 560.4 0.5 2e-168 560.1 0.5 1.1 1 0 0 1 1 1 1 ATP P2X receptor Connexin PF00029.17 NM_153368.2_3 - 5.9e-70 235.4 0.0 8.7e-70 234.9 0.0 1.2 1 0 0 1 1 1 1 Connexin Alpha_E3_glycop PF01563.14 NM_153368.2_3 - 0.0027 17.6 2.5 0.0073 16.2 0.1 2.4 2 0 0 2 2 2 1 Alphavirus E3 glycoprotein PQ-loop PF04193.12 NM_004870.3_1 - 2.2e-20 72.0 2.9 2.9e-13 49.3 0.5 2.8 3 0 0 3 3 3 2 PQ loop repeat 7tm_1 PF00001.19 NM_000861.3_3 - 9.3e-68 228.2 0.3 1.3e-67 227.7 0.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_000861.3_3 - 2.3e-06 27.4 11.7 8.6e-06 25.5 5.4 2.5 2 1 0 2 2 2 2 Olfactory receptor DUF4782 PF16016.3 NM_001172105.1_2 - 3.7e-34 118.2 0.8 3.7e-34 118.2 0.8 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4782) TarH PF02203.13 NM_001172105.1_2 - 0.013 15.3 1.6 0.02 14.7 1.6 1.2 1 0 0 1 1 1 0 Tar ligand binding domain homologue DUF4446 PF14584.4 NM_001172105.1_2 - 0.086 12.7 1.5 0.17 11.7 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF2462 PF09495.8 NM_014047.2_3 - 9.6e-22 77.4 13.5 9.6e-22 77.4 13.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2462) HCR PF07111.10 NM_019052.3_1 - 0 1462.2 108.3 0 1462.0 108.3 1.0 1 0 0 1 1 1 1 Alpha helical coiled-coil rod protein (HCR) SpoVIF PF14069.4 NM_019052.3_1 - 0.15 11.7 7.4 0.034 13.8 1.7 2.9 3 0 0 3 3 3 0 Stage VI sporulation protein F PITH PF06201.11 NM_020362.4_2 - 1.7e-41 141.8 0.0 2.3e-41 141.4 0.0 1.2 1 0 0 1 1 1 1 PITH domain zf-H2C2_2 PF13465.4 NM_153207.4_3 - 0.00041 20.5 0.0 0.002 18.4 0.0 2.3 1 0 0 1 1 1 1 Zinc-finger double domain zf-C2H2 PF00096.24 NM_153207.4_3 - 0.0022 18.2 17.6 0.87 10.0 1.2 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type DUF4764 PF15961.3 NM_153207.4_3 - 0.071 11.7 0.5 0.11 11.0 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4764) DUF4366 PF14283.4 NM_153207.4_3 - 1.5 8.1 4.5 3.2 7.0 4.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) zf-C2H2_11 PF16622.3 NM_153207.4_3 - 2.6 7.8 8.7 6 6.6 0.0 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type DNA_pol_phi PF04931.11 NM_153207.4_3 - 2.8 5.8 11.0 4.2 5.2 11.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi FSIP1 PF15554.4 NM_001324338.1_2 - 6.1e-169 562.2 35.4 6.1e-169 562.2 35.4 1.5 2 0 0 2 2 2 1 FSIP1 family Ribosomal_L16 PF00252.16 NM_006013.4_3 - 2.3e-43 147.3 0.3 3.2e-43 146.8 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Ras PF00071.20 NM_001142624.2_2 - 4.3e-38 130.3 0.1 5.9e-38 129.9 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001142624.2_2 - 1.6e-27 96.0 0.0 2.5e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001142624.2_2 - 5.1e-10 38.9 0.0 7.6e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001142624.2_2 - 3.7e-06 26.9 0.0 6.5e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 NM_001142624.2_2 - 0.0048 16.8 0.1 2.7 7.9 0.0 3.3 3 1 0 3 3 3 1 Dynamin family Gtr1_RagA PF04670.10 NM_001142624.2_2 - 0.031 13.5 0.0 0.042 13.1 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region TniB PF05621.9 NM_001142624.2_2 - 0.13 11.3 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.8 NM_001142624.2_2 - 0.19 11.0 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit CLASP_N PF12348.6 NM_015097.2_2 - 4.3e-52 176.8 5.2 4.2e-39 134.3 0.1 4.2 4 0 0 4 4 4 3 CLASP N terminal HEAT PF02985.20 NM_015097.2_2 - 4.4e-13 48.1 11.4 0.0018 18.2 0.0 8.4 9 0 0 9 9 8 3 HEAT repeat HEAT_EZ PF13513.4 NM_015097.2_2 - 5.5e-10 39.4 0.5 0.025 14.9 0.0 5.8 5 0 0 5 5 5 2 HEAT-like repeat Cnd1 PF12717.5 NM_015097.2_2 - 7.9e-08 32.3 6.6 0.0038 17.1 0.8 5.2 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.7 NM_015097.2_2 - 6e-05 23.0 2.2 0.032 14.3 0.2 3.6 3 0 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 TFCD_C PF12612.6 NM_015097.2_2 - 0.0017 18.2 0.3 0.096 12.4 0.1 3.5 4 0 0 4 4 4 1 Tubulin folding cofactor D C terminal TAN PF11640.6 NM_015097.2_2 - 0.013 15.5 1.7 0.18 11.8 0.1 3.5 3 1 1 4 4 4 0 Telomere-length maintenance and DNA damage repair Ipi1_N PF12333.6 NM_015097.2_2 - 0.014 15.9 0.7 1.2 9.7 0.0 3.4 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation Vac14_Fab1_bd PF12755.5 NM_015097.2_2 - 0.044 14.2 3.1 38 4.8 0.0 5.2 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region ParcG PF10274.7 NM_015097.2_2 - 0.051 13.5 0.4 0.21 11.6 0.1 2.1 2 0 0 2 2 2 0 Parkin co-regulated protein MMS19_C PF12460.6 NM_015097.2_2 - 0.12 11.4 6.2 0.76 8.7 0.5 3.1 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal Kinesin PF00225.21 NM_001105568.2_2 - 2.6e-113 378.2 0.0 4.1e-113 377.5 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.6 NM_001105568.2_2 - 4.6e-30 105.1 0.0 1.8e-29 103.2 0.0 2.1 1 1 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.3 NM_001105568.2_2 - 6.7e-25 88.1 20.4 3e-19 69.7 2.3 4.5 3 1 1 4 4 4 2 Kinesin-associated Microtub_bd PF16796.3 NM_001105568.2_2 - 2e-23 82.9 0.0 4.7e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding KIF1B PF12423.6 NM_001105568.2_2 - 2.3e-16 59.9 0.0 7.4e-16 58.3 0.0 2.0 1 0 0 1 1 1 1 Kinesin protein 1B FHA PF00498.24 NM_001105568.2_2 - 1.9e-05 24.7 0.2 0.00013 22.1 0.0 2.4 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.3 NM_001105568.2_2 - 0.002 18.3 0.0 0.0054 16.9 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Dynamin_N PF00350.21 NM_001105568.2_2 - 0.35 10.8 3.5 0.65 9.9 0.0 3.0 3 0 0 3 3 3 0 Dynamin family KMP11 PF03037.14 NM_001105568.2_2 - 0.4 11.4 4.6 0.32 11.7 1.5 2.3 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 Creatinase_N PF01321.16 NM_001105568.2_2 - 0.6 10.6 2.3 0.75 10.3 0.1 2.3 2 1 1 3 3 3 0 Creatinase/Prolidase N-terminal domain FANCF PF11107.6 NM_022725.3_2 - 4.9e-131 436.9 0.0 5.8e-131 436.7 0.0 1.1 1 0 0 1 1 1 1 Fanconi anemia group F protein (FANCF) Filament PF00038.19 NM_001256282.1_3 - 1.8e-116 389.0 42.2 2.1e-116 388.8 42.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 NM_001256282.1_3 - 1e-11 45.2 10.2 1e-11 45.2 10.2 2.6 2 1 0 2 2 2 1 Keratin type II head TPR_MLP1_2 PF07926.10 NM_001256282.1_3 - 4.6e-05 23.4 35.3 9.2e-05 22.4 3.6 4.0 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 NM_001256282.1_3 - 0.00058 18.7 37.5 0.064 12.0 12.6 3.2 1 1 1 2 2 2 2 Spc7 kinetochore protein CENP-F_leu_zip PF10473.7 NM_001256282.1_3 - 0.00066 19.6 37.9 0.021 14.7 8.0 3.8 1 1 3 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.6 NM_001256282.1_3 - 0.0012 18.8 28.1 0.012 15.5 6.5 3.9 2 2 0 3 3 3 2 Afadin- and alpha -actinin-Binding CALCOCO1 PF07888.9 NM_001256282.1_3 - 0.0015 17.0 33.6 0.0077 14.7 18.2 2.1 1 1 1 2 2 2 2 Calcium binding and coiled-coil domain (CALCOCO1) like IncA PF04156.12 NM_001256282.1_3 - 0.0028 17.3 33.9 0.035 13.8 5.9 3.3 1 1 2 3 3 3 2 IncA protein DivIC PF04977.13 NM_001256282.1_3 - 0.02 14.5 0.5 0.02 14.5 0.5 5.6 4 2 2 6 6 5 0 Septum formation initiator TraC PF07820.10 NM_001256282.1_3 - 0.022 14.9 4.6 0.21 11.8 2.4 2.9 2 0 0 2 2 2 0 TraC-like protein TolA_bind_tri PF16331.3 NM_001256282.1_3 - 0.023 14.6 1.1 0.023 14.6 1.1 5.6 5 2 1 6 6 6 0 TolA binding protein trimerisation Taxilin PF09728.7 NM_001256282.1_3 - 0.083 12.0 32.1 0.32 10.1 32.0 1.9 1 1 0 1 1 1 0 Myosin-like coiled-coil protein HTH_Tnp_Tc3_1 PF11427.6 NM_001256282.1_3 - 0.14 11.8 0.5 5.9 6.7 0.0 2.6 2 0 0 2 2 2 0 Tc3 transposase Jnk-SapK_ap_N PF09744.7 NM_001256282.1_3 - 0.51 10.4 33.4 0.56 10.3 7.7 3.4 1 1 1 3 3 3 0 JNK_SAPK-associated protein-1 ABC_tran_CTD PF16326.3 NM_001256282.1_3 - 0.51 10.5 32.4 0.05 13.7 7.3 4.4 3 2 1 4 4 4 0 ABC transporter C-terminal domain Baculo_PEP_C PF04513.10 NM_001256282.1_3 - 0.62 10.0 18.2 4.2 7.3 0.4 3.9 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus COMP PF11598.6 NM_001256282.1_3 - 1 9.7 4.6 3.6 8.0 0.9 2.8 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein Alanine_zipper PF11839.6 NM_001256282.1_3 - 1.4 9.1 9.2 0.56 10.4 5.7 2.1 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein GAS PF13851.4 NM_001256282.1_3 - 1.5 8.0 36.7 0.4 9.9 9.9 3.7 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.9 NM_001256282.1_3 - 1.5 8.8 32.7 2.7 8.0 3.4 4.0 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) E2R135 PF11570.6 NM_001256282.1_3 - 1.5 8.9 8.2 0.16 12.1 1.9 2.5 2 1 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF1451 PF07295.9 NM_001256282.1_3 - 1.7 8.6 15.0 2.7 7.9 2.0 2.8 2 1 0 2 2 2 0 Zinc-ribbon containing domain DUF1664 PF07889.10 NM_001256282.1_3 - 1.8 8.4 21.9 0.32 10.9 1.2 4.6 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) Cnn_1N PF07989.9 NM_001256282.1_3 - 2.6 8.1 21.6 0.045 13.8 2.5 4.1 2 2 1 3 3 3 0 Centrosomin N-terminal motif 1 BRE1 PF08647.9 NM_001256282.1_3 - 6.4 6.8 35.8 0.05 13.6 5.8 4.7 1 1 2 4 4 4 0 BRE1 E3 ubiquitin ligase DUF5082 PF16888.3 NM_001256282.1_3 - 7.2 6.9 31.7 0.093 12.9 4.4 4.4 1 1 1 3 3 3 0 Domain of unknown function (DUF5082) CHDCT2 PF08074.9 NM_001256282.1_3 - 9.8 6.2 16.5 0.8 9.7 6.2 2.6 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain Ig_3 PF13927.4 NM_001243280.1_1 - 6.2e-27 93.9 7.1 1.6e-07 31.7 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain C2-set_2 PF08205.10 NM_001243280.1_1 - 1.6e-25 88.9 0.1 1.4e-19 69.8 0.0 3.7 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 NM_001243280.1_1 - 7.4e-19 67.7 3.4 0.00022 21.4 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.14 NM_001243280.1_1 - 2.7e-11 43.2 5.3 0.024 14.5 0.0 6.3 6 1 0 6 6 6 2 Immunoglobulin I-set domain ig PF00047.23 NM_001243280.1_1 - 3.2e-08 33.5 4.9 0.35 11.0 0.0 7.0 5 2 1 6 6 6 2 Immunoglobulin domain C1-set PF07654.13 NM_001243280.1_1 - 8.4e-07 29.3 0.6 0.08 13.3 0.0 4.1 4 1 0 4 4 4 2 Immunoglobulin C1-set domain V-set PF07686.15 NM_001243280.1_1 - 7e-06 26.0 3.1 0.023 14.7 0.0 5.1 5 2 0 5 5 5 1 Immunoglobulin V-set domain DUF4366 PF14283.4 NM_001243280.1_1 - 0.0085 15.5 0.1 0.013 14.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) PepSY_TM PF03929.14 NM_001243280.1_1 - 0.082 12.1 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 PepSY-associated TM region LRR_8 PF13855.4 NM_001145307.4_2 - 9.8e-07 28.3 1.5 9.8e-07 28.3 1.5 2.1 2 0 0 2 2 2 1 Leucine rich repeat LRR_9 PF14580.4 NM_001145307.4_2 - 2.1e-05 24.0 0.1 7.5e-05 22.2 0.0 1.8 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 NM_001145307.4_2 - 9.7e-05 22.5 6.1 0.0028 17.8 0.3 3.1 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) zf-H2C2_2 PF13465.4 NM_001289169.1_1 - 1.3e-131 423.5 152.6 8.5e-09 35.3 0.3 20.8 20 1 1 21 21 20 19 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001289169.1_1 - 2.1e-89 289.1 136.6 2.1e-06 27.7 0.2 19.8 19 0 0 19 19 19 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001289169.1_1 - 3.3e-45 148.7 141.6 0.0041 17.7 0.3 20.2 21 0 0 21 21 19 17 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001289169.1_1 - 4.7e-22 77.6 71.1 0.27 11.5 0.1 17.9 18 0 0 18 18 17 9 Zinc-finger double-stranded RNA-binding KRAB PF01352.25 NM_001289169.1_1 - 4.7e-20 70.8 0.3 8.3e-20 70.1 0.3 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001289169.1_1 - 1.9e-12 46.9 99.9 0.03 14.3 2.2 13.1 4 2 12 16 16 16 13 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001289169.1_1 - 6.6e-12 45.0 118.6 0.018 14.9 0.5 19.5 20 0 0 20 20 20 10 C2H2-type zinc finger XPA_N PF01286.16 NM_001289169.1_1 - 5.8e-07 29.3 86.1 1.3 8.9 0.0 17.8 18 0 0 18 18 18 5 XPA protein N-terminal zf-met PF12874.5 NM_001289169.1_1 - 3e-05 24.1 114.5 0.035 14.3 0.3 17.4 18 0 0 18 18 18 7 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 NM_001289169.1_1 - 0.00011 22.7 70.9 1.3 9.6 0.4 9.7 4 2 6 11 11 10 5 zinc-ribbon family Herpes_ORF11 PF04797.11 NM_001289169.1_1 - 0.0041 15.8 0.0 4.2 5.9 0.0 3.4 2 1 2 4 4 4 1 Herpesvirus dUTPase protein DUF3268 PF11672.6 NM_001289169.1_1 - 0.0043 17.2 59.2 0.23 11.7 1.0 8.7 3 2 2 9 9 9 6 zinc-finger-containing domain CpXC PF14353.4 NM_001289169.1_1 - 0.056 13.4 60.1 4.7 7.1 0.2 15.2 5 3 7 13 13 13 0 CpXC protein C1_4 PF07975.10 NM_001289169.1_1 - 0.097 12.8 78.9 1.1 9.5 2.2 12.8 1 1 11 14 14 14 0 TFIIH C1-like domain BolA PF01722.16 NM_001289169.1_1 - 0.62 10.3 28.2 2.6 8.3 0.4 7.2 5 3 1 6 6 6 0 BolA-like protein HypA PF01155.17 NM_001289169.1_1 - 2.8 7.9 63.3 1.6 8.6 0.8 9.8 1 1 7 8 8 7 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Alk_phosphatase PF00245.18 NM_001631.4_2 - 4.8e-184 612.0 0.0 5.8e-184 611.7 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.16 NM_001631.4_2 - 0.11 11.7 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily UPF0020 PF01170.16 NM_001114092.1_2 - 3.3e-49 167.1 0.0 4.8e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 THUMP PF02926.15 NM_001114092.1_2 - 6.4e-12 45.6 1.6 2e-11 44.1 0.7 2.1 1 1 1 2 2 2 1 THUMP domain Methyltransf_25 PF13649.4 NM_001114092.1_2 - 0.00053 20.5 0.0 0.0011 19.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 NM_001114092.1_2 - 0.062 12.7 0.1 2.4 7.5 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase small domain Ras PF00071.20 NM_001251922.1_1 - 6.7e-36 123.2 0.3 7.9e-18 64.4 0.1 2.2 1 1 1 2 2 2 2 Ras family Roc PF08477.11 NM_001251922.1_1 - 3.2e-08 33.7 0.1 2.3e-07 30.9 0.0 2.1 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase DUF258 PF03193.14 NM_001251922.1_1 - 0.091 12.5 0.3 7.8 6.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF3361 PF11841.6 NM_001322501.1_2 - 6.4e-05 22.8 4.5 0.19 11.5 0.1 4.9 5 0 0 5 5 5 1 Domain of unknown function (DUF3361) RICTOR_V PF14668.4 NM_001322501.1_2 - 0.0041 17.2 6.2 8.3 6.6 0.0 4.6 4 1 1 5 5 5 2 Rapamycin-insensitive companion of mTOR, domain 5 Arm PF00514.21 NM_001322501.1_2 - 0.0053 16.6 1.3 1.1 9.3 0.0 5.0 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat HEAT PF02985.20 NM_001322501.1_2 - 0.017 15.2 4.7 5.1 7.5 0.0 4.9 5 0 0 5 5 5 0 HEAT repeat DUF3385 PF11865.6 NM_001322501.1_2 - 0.045 13.5 0.0 0.22 11.2 0.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3385) Cnd1 PF12717.5 NM_001322501.1_2 - 0.058 13.3 0.5 3.7 7.4 0.2 2.9 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Sec7_N PF12783.5 NM_001322501.1_2 - 0.06 13.2 0.1 0.06 13.2 0.1 4.5 4 1 0 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT_2 PF13646.4 NM_001322501.1_2 - 0.074 13.3 0.9 6.8 7.0 0.1 4.3 4 2 1 5 5 5 0 HEAT repeats Pkinase PF00069.23 NM_001322501.1_3 - 5.9e-40 137.2 0.0 9.9e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001322501.1_3 - 2.9e-23 82.3 0.0 9.1e-14 51.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase SCAN PF02023.15 NM_017810.3_2 - 1.2e-43 146.7 5.1 1.9e-43 146.0 5.1 1.3 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 NM_017810.3_3 - 1.7e-41 138.7 44.7 7.4e-09 35.5 0.2 7.7 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_017810.3_3 - 3.8e-32 108.8 50.8 5.9e-07 29.5 0.6 7.6 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_017810.3_3 - 2.3e-19 68.3 51.1 0.0019 18.7 0.5 8.1 8 0 0 8 8 7 6 C2H2-type zinc finger Myb_DNA-bind_4 PF13837.4 NM_017810.3_3 - 6.6e-16 58.4 0.0 1.3e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain zf-C2H2_jaz PF12171.6 NM_017810.3_3 - 2.4e-14 53.1 20.7 0.03 14.5 0.1 6.9 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_017810.3_3 - 4.6e-06 26.3 38.8 0.005 16.6 1.2 6.9 6 1 0 6 6 6 4 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_017810.3_3 - 6.3e-06 26.1 19.4 0.086 12.8 0.5 4.8 3 3 1 4 4 4 3 Zinc ribbon domain KRAB PF01352.25 NM_017810.3_3 - 0.00022 20.7 0.0 0.00044 19.7 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_11 PF16622.3 NM_017810.3_3 - 0.0024 17.4 29.0 0.54 9.9 0.5 6.4 6 0 0 6 6 6 2 zinc-finger C2H2-type BolA PF01722.16 NM_017810.3_3 - 0.0047 17.0 6.3 1.3 9.2 0.6 2.9 3 0 0 3 3 3 2 BolA-like protein zf-C2HC_2 PF13913.4 NM_017810.3_3 - 0.0062 16.3 19.2 0.1 12.4 0.3 5.5 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-met PF12874.5 NM_017810.3_3 - 0.015 15.5 39.7 0.14 12.4 2.0 6.7 6 0 0 6 6 6 0 Zinc-finger of C2H2 type HTH_18 PF12833.5 NM_017810.3_3 - 0.032 14.3 2.2 48 4.2 0.1 3.7 3 1 0 3 3 3 0 Helix-turn-helix domain XPA_N PF01286.16 NM_017810.3_3 - 0.05 13.5 17.3 3.3 7.7 0.0 6.1 6 0 0 6 6 6 0 XPA protein N-terminal zf-LYAR PF08790.9 NM_017810.3_3 - 0.38 10.6 15.4 2.6 7.9 0.2 5.4 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger Zf_RING PF16744.3 NM_017810.3_3 - 0.96 9.5 8.0 20 5.3 0.1 4.3 1 1 2 4 4 4 0 KIAA1045 RING finger zinc_ribbon_15 PF17032.3 NM_017810.3_3 - 2.9 8.6 28.2 1.1 9.9 1.2 4.2 1 1 2 4 4 3 0 zinc-ribbon family DUF3268 PF11672.6 NM_017810.3_3 - 6.3 7.0 12.8 13 6.0 0.6 3.6 4 0 0 4 4 4 0 zinc-finger-containing domain TMEM51 PF15345.4 NM_001242774.2_3 - 0.004 16.9 6.2 0.0076 16.0 6.2 1.4 1 1 0 1 1 1 1 Transmembrane protein 51 Patatin PF01734.20 NM_001256007.2_3 - 1.4e-23 84.0 0.0 2.6e-23 83.1 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase SMC_ScpB PF04079.14 NM_001256007.2_3 - 0.049 13.1 0.2 0.15 11.6 0.2 1.7 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB Vezatin PF12632.5 NM_017599.3_1 - 2.3e-96 322.3 2.8 2.3e-96 322.3 2.8 2.1 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes ATPase_2 PF01637.16 NM_017599.3_1 - 0.044 13.5 0.1 0.044 13.5 0.1 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea PDZ PF00595.22 NM_003687.3_3 - 7.5e-16 58.1 0.0 1.2e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LIM PF00412.20 NM_003687.3_3 - 1.1e-14 54.2 3.3 1.1e-14 54.2 3.3 1.9 2 0 0 2 2 2 1 LIM domain DUF4749 PF15936.3 NM_003687.3_3 - 1.1e-10 42.4 0.0 2e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ_2 PF13180.4 NM_003687.3_3 - 0.22 11.7 0.0 0.39 10.9 0.0 1.3 1 0 0 1 1 1 0 PDZ domain DUF3338 PF11819.6 NM_001271836.1_3 - 7.5e-44 148.9 1.8 1.3e-43 148.2 1.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) HR1 PF02185.14 NM_001271836.1_3 - 6.1 6.9 7.9 13 5.9 7.9 1.5 1 0 0 1 1 1 0 Hr1 repeat DUF719 PF05334.11 NM_001317995.1_1 - 1.2e-53 182.0 5.5 5.1e-53 180.0 0.6 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF719) IPK PF03770.14 NM_025194.2_1 - 2.1e-38 132.1 0.0 3.6e-38 131.3 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase HIG_1_N PF04588.11 NM_001099669.1_3 - 6.1e-16 58.3 1.2 1e-15 57.5 1.2 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Pkinase PF00069.23 NM_001321568.1_2 - 1.2e-74 250.9 0.0 1.6e-74 250.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CaMKII_AD PF08332.8 NM_001321568.1_2 - 1.8e-59 199.3 0.0 2.7e-59 198.8 0.0 1.3 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.15 NM_001321568.1_2 - 3.5e-31 108.3 0.0 5.3e-31 107.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4440 PF14534.4 NM_001321568.1_2 - 2.1e-08 34.4 0.0 3.4e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.4 NM_001321568.1_2 - 4.1e-08 33.4 0.0 6.9e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain Kdo PF06293.12 NM_001321568.1_2 - 0.011 15.0 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SnoaL_4 PF13577.4 NM_001321568.1_2 - 0.032 14.2 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like domain SnoaL_2 PF12680.5 NM_001321568.1_2 - 0.11 13.0 0.0 0.19 12.3 0.0 1.4 1 0 0 1 1 1 0 SnoaL-like domain APH PF01636.21 NM_001321568.1_2 - 0.57 9.9 6.4 2 8.1 0.1 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family F420_oxidored PF03807.15 NM_138637.2_3 - 7.1e-17 61.7 0.0 1.2e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.17 NM_138637.2_3 - 5.2e-10 39.4 2.8 9.5e-10 38.6 2.8 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_2 PF03446.13 NM_138637.2_3 - 0.0017 18.4 0.0 0.0033 17.5 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.18 NM_138637.2_3 - 0.0036 17.2 0.0 0.0063 16.5 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.17 NM_138637.2_3 - 0.012 14.9 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.10 NM_138637.2_3 - 0.037 13.5 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.12 NM_001184700.1_3 - 1.5e-36 125.6 0.1 3.8e-26 91.7 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.13 NM_001184700.1_3 - 5.8e-36 123.0 0.0 1.8e-34 118.2 0.0 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.17 NM_001184700.1_3 - 2.2e-32 111.0 0.1 4.1e-32 110.1 0.1 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain 3HCDH_N PF02737.16 NM_001184700.1_3 - 0.075 12.8 0.0 1.3 8.7 0.0 2.3 2 1 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain U-box PF04564.13 NM_014948.3_1 - 2.7e-26 91.4 0.1 5.2e-26 90.5 0.1 1.5 1 0 0 1 1 1 1 U-box domain zf-RING_5 PF14634.4 NM_014948.3_1 - 4.7e-05 23.1 7.1 4.7e-05 23.1 7.1 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_014948.3_1 - 0.00017 21.4 5.4 0.00017 21.4 5.4 2.4 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.4 NM_014948.3_1 - 0.00021 20.9 5.5 0.00021 20.9 5.5 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 NM_014948.3_1 - 0.0037 16.9 5.7 0.0037 16.9 5.7 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.20 NM_001163121.1_2 - 2.4e-05 23.9 0.0 4.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rad52_Rad22 PF04098.13 NM_001163121.1_2 - 0.0012 18.6 0.0 0.0017 18.2 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein TNFR_c6 PF00020.16 NM_003842.4_3 - 5.9e-20 71.3 22.0 6.3e-12 45.6 6.4 3.5 2 1 1 3 3 3 2 TNFR/NGFR cysteine-rich region Death PF00531.20 NM_003842.4_3 - 7.1e-17 61.2 0.1 1.3e-16 60.4 0.1 1.5 1 0 0 1 1 1 1 Death domain RskA PF10099.7 NM_003842.4_3 - 0.28 11.3 9.2 3.4 7.8 7.4 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA HSP70 PF00012.18 NM_021979.3_2 - 5.8e-261 866.8 8.3 6.7e-261 866.6 8.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 NM_021979.3_2 - 5.4e-17 61.5 0.4 1.6e-15 56.6 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 NM_021979.3_2 - 0.00043 20.5 0.6 2.5 8.5 0.0 3.4 3 0 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 NM_021979.3_2 - 0.0016 18.0 0.0 0.0035 16.9 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.18 NM_021979.3_2 - 0.012 15.0 0.1 1.4 8.2 0.0 2.2 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family PRY PF13765.4 NM_001303419.1_1 - 4.1e-16 58.2 0.0 1e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 NM_001303419.1_1 - 4.2e-12 46.1 0.0 7.8e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 NM_001303419.1_1 - 5.2e-06 26.4 7.8 1.2e-05 25.2 7.8 1.6 1 0 0 1 1 1 1 B-box zinc finger zf-UBR PF02207.18 NM_001303419.1_1 - 0.029 14.4 4.0 0.1 12.7 4.0 2.0 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Exonuc_VII_L PF02601.13 NM_001303419.1_1 - 0.036 13.5 7.5 0.055 12.9 7.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sigma54_CBD PF04963.11 NM_001303419.1_1 - 0.17 11.6 5.5 0.14 11.8 1.8 2.3 1 1 0 2 2 2 0 Sigma-54 factor, core binding domain CENP-K PF11802.6 NM_001303419.1_1 - 0.87 9.0 18.1 1.4 8.3 18.1 1.2 1 0 0 1 1 1 0 Centromere-associated protein K ZYG-11_interact PF05884.10 NM_001303419.1_1 - 4.9 6.4 7.1 29 3.8 4.4 2.6 2 1 0 2 2 2 0 Interactor of ZYG-11 BMFP PF04380.11 NM_001303419.1_1 - 6.8 7.1 15.8 0.22 11.9 5.3 2.8 1 1 2 3 3 3 0 Membrane fusogenic activity CRF PF00473.15 NM_000756.3_2 - 1.3e-15 57.1 1.1 1.3e-15 57.1 1.1 2.1 2 0 0 2 2 2 1 Corticotropin-releasing factor family VPS9 PF02204.16 NM_004292.2_2 - 3.6e-21 75.2 0.0 5.5e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RA PF00788.21 NM_004292.2_2 - 3.9e-05 24.1 0.0 0.00011 22.7 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SH2 PF00017.22 NM_004292.2_2 - 0.0049 16.8 0.0 0.0096 15.8 0.0 1.5 1 0 0 1 1 1 1 SH2 domain CLAMP PF14769.4 NM_173554.2_3 - 1.6e-22 79.7 0.6 3.4e-22 78.6 0.5 1.6 2 0 0 2 2 2 1 Flagellar C1a complex subunit C1a-32 PRELI PF04707.12 NM_016045.2_3 - 3.7e-57 192.4 0.1 5e-57 192.0 0.1 1.1 1 0 0 1 1 1 1 PRELI-like family LAT PF15234.4 NM_001014987.1_2 - 2.7e-122 407.0 10.4 3.5e-122 406.6 10.4 1.1 1 0 0 1 1 1 1 Linker for activation of T-cells LAX PF15681.3 NM_001014987.1_2 - 0.56 8.7 5.9 1.6 7.2 5.9 1.8 1 1 0 1 1 1 0 Lymphocyte activation family X BEN PF10523.7 NM_001173541.1_3 - 1.2e-07 31.7 0.0 2.9e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 BEN domain DUF1845 PF08900.9 NM_001173541.1_3 - 0.009 15.6 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1845) SET PF00856.26 NM_001007261.2_2 - 3e-13 50.4 0.0 4.9e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 SET domain ELO PF01151.16 NM_001301856.1_2 - 9.9e-64 215.1 23.7 1.5e-63 214.5 23.7 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family Lig_chan PF00060.24 NM_133445.2_2 - 3.2e-28 98.3 0.0 5.8e-28 97.5 0.0 1.5 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_133445.2_2 - 3.6e-26 91.5 0.0 1.2e-25 89.7 0.0 1.8 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_133445.2_2 - 1.9e-20 73.1 0.0 2.9e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.26 NM_133445.2_2 - 3.4e-07 29.6 0.0 2.4e-05 23.5 0.0 2.3 1 1 0 1 1 1 1 Receptor family ligand binding region zf-B_box PF00643.22 NM_001282378.1_3 - 2.4e-10 40.2 22.7 7.6e-10 38.7 6.4 3.3 3 0 0 3 3 3 2 B-box zinc finger fn3 PF00041.19 NM_001282378.1_3 - 0.0038 17.4 0.0 0.0065 16.7 0.0 1.3 1 0 0 1 1 1 1 Fibronectin type III domain CEBP_ZZ PF16366.3 NM_001282378.1_3 - 0.37 10.9 11.2 0.033 14.3 2.0 2.7 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain YL1_C PF08265.9 NM_001098817.1_1 - 6.2e-10 38.5 0.0 1.7e-09 37.1 0.0 1.8 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DUF5077 PF16871.3 NM_001098817.1_1 - 0.067 12.9 0.0 0.099 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5077) LRR_8 PF13855.4 NM_002544.4_1 - 1.9e-16 59.4 32.8 1.3e-10 40.7 6.9 4.3 2 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_002544.4_1 - 1.6e-15 56.7 33.6 2.3e-05 24.5 1.4 5.0 3 2 2 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_002544.4_1 - 6.8e-09 34.8 26.3 0.12 12.7 0.3 7.5 6 1 1 7 7 7 5 Leucine Rich Repeat LRRNT PF01462.16 NM_002544.4_1 - 9.9e-09 34.5 3.3 3.8e-08 32.7 3.3 2.1 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain SERTA PF06031.11 NM_002544.4_1 - 0.077 12.5 0.1 0.077 12.5 0.1 2.5 3 0 0 3 3 3 0 SERTA motif LRR_9 PF14580.4 NM_002544.4_1 - 1 8.7 10.7 1.2 8.5 3.6 2.6 2 1 1 3 3 3 0 Leucine-rich repeat DUF4209 PF13910.4 NM_001278533.1_1 - 2.7e-30 104.3 0.7 3.1e-24 84.9 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4209) BIR PF00653.19 NM_001167.3_1 - 1.2e-59 198.7 7.9 2.9e-21 75.8 1.6 3.7 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.4 NM_001167.3_1 - 5.4e-12 45.2 8.9 5.4e-12 45.2 8.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_001167.3_1 - 2.2e-05 24.1 8.0 4.3e-05 23.1 8.0 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 SET PF00856.26 NM_001300909.1_1 - 6.3e-12 46.1 0.6 1.1e-11 45.2 0.1 1.7 2 0 0 2 2 2 1 SET domain NDK PF00334.17 NM_001308433.1_2 - 2.6e-15 56.5 0.0 4.5e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Nucleoside diphosphate kinase NDK PF00334.17 NM_001308433.1_3 - 8.3e-08 32.2 0.0 1.2e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Pkinase PF00069.23 NM_016440.3_2 - 4.7e-10 39.1 0.0 7e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain zinc_ribbon_2 PF13240.4 NM_016440.3_2 - 3.8e-07 29.5 4.3 8.5e-07 28.4 4.3 1.7 1 0 0 1 1 1 1 zinc-ribbon domain Pkinase_Tyr PF07714.15 NM_016440.3_2 - 1.8e-06 27.3 0.0 2.6e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DZR PF12773.5 NM_016440.3_2 - 2.1e-05 24.3 0.2 5.1e-05 23.1 0.2 1.6 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_15 PF17032.3 NM_016440.3_2 - 0.00014 22.4 0.3 0.00035 21.1 0.3 1.7 1 0 0 1 1 1 1 zinc-ribbon family zf-ribbon_3 PF13248.4 NM_016440.3_2 - 0.00089 18.5 4.1 0.0014 17.9 2.9 2.1 2 0 0 2 2 2 1 zinc-ribbon domain UPF0547 PF10571.7 NM_016440.3_2 - 0.0013 18.6 2.4 0.0034 17.3 2.4 1.8 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 RNA_POL_M_15KD PF02150.14 NM_016440.3_2 - 0.014 15.1 3.2 1.2 8.9 0.1 2.9 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit Nudix_N_2 PF14803.4 NM_016440.3_2 - 0.25 11.2 2.2 10 6.0 0.1 2.7 2 0 0 2 2 2 0 Nudix N-terminal zf-C3HC4_3 PF13920.4 NM_016440.3_2 - 0.51 10.1 2.2 0.84 9.4 0.5 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-H2C2_2 PF13465.4 NM_024967.2_1 - 4.7e-47 156.3 85.4 3.1e-08 33.6 1.1 12.6 11 1 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_024967.2_1 - 4.6e-29 99.1 84.5 1.9e-06 27.9 1.3 10.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_024967.2_1 - 1.3e-28 97.1 80.4 0.00033 21.1 1.2 10.2 10 0 0 10 10 10 9 C2H2-type zinc finger KRAB PF01352.25 NM_024967.2_1 - 3.2e-22 77.8 0.7 5.1e-22 77.2 0.7 1.3 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_024967.2_1 - 5.6e-08 32.4 76.7 0.0035 17.1 3.6 9.7 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_024967.2_1 - 8.2e-08 32.2 45.1 0.012 15.7 0.9 8.9 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_024967.2_1 - 2.1e-06 27.6 48.6 0.1 12.6 3.7 8.3 4 2 5 9 9 9 5 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_024967.2_1 - 0.00045 19.8 55.2 0.49 10.1 0.3 9.4 9 0 0 9 9 9 4 zinc-finger C2H2-type zf-met PF12874.5 NM_024967.2_1 - 0.081 13.2 0.7 0.081 13.2 0.7 8.1 7 0 0 7 7 7 0 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 NM_024967.2_1 - 0.091 13.4 41.8 1.1 10.0 1.5 5.5 2 1 4 7 7 7 0 zinc-ribbon family ADK_lid PF05191.12 NM_024967.2_1 - 0.17 11.8 25.6 3.1 7.8 0.1 6.3 3 2 2 5 5 5 0 Adenylate kinase, active site lid zf-trcl PF13451.4 NM_024967.2_1 - 0.27 11.0 34.0 27 4.6 0.0 9.0 9 0 0 9 9 9 0 Probable zinc-ribbon domain C1_4 PF07975.10 NM_024967.2_1 - 2.9 8.1 0.0 2.9 8.1 0.0 7.9 3 1 4 8 8 8 0 TFIIH C1-like domain XPA_N PF01286.16 NM_024967.2_1 - 5.3 7.0 46.7 1 9.3 0.1 9.2 9 0 0 9 9 9 0 XPA protein N-terminal Phtf-FEM1B_bdg PF12129.6 NM_001127357.1_1 - 1.7e-69 232.4 1.2 1.7e-69 232.4 1.2 2.1 2 0 0 2 2 2 1 Male germ-cell putative homeodomain transcription factor Pkinase PF00069.23 NM_017490.3_1 - 4.8e-76 255.5 0.0 6.3e-76 255.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_017490.3_1 - 1.2e-44 152.5 0.0 2e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 NM_017490.3_1 - 1.6e-20 72.5 0.0 2.9e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.4 NM_017490.3_1 - 1.6e-06 27.5 0.0 3e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like UBA PF00627.29 NM_017490.3_1 - 3.6e-05 23.4 0.0 5.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 UBA/TS-N domain UBA_2 PF08587.9 NM_017490.3_1 - 0.0019 18.2 0.1 0.0038 17.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) RIO1 PF01163.20 NM_017490.3_1 - 0.0021 17.5 0.3 0.0039 16.7 0.3 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 NM_017490.3_1 - 0.022 14.0 0.1 0.039 13.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF702 PF05142.10 NM_017490.3_1 - 1.6 9.0 5.6 0.42 10.9 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Leader_Trp PF08255.9 NM_017490.3_3 - 0.12 12.2 1.6 0.4 10.6 1.6 1.9 1 0 0 1 1 1 0 Trp-operon Leader Peptide SPRY PF00622.26 NM_015163.5_1 - 5.6e-13 48.9 0.0 9.3e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 SPRY domain fn3 PF00041.19 NM_015163.5_1 - 1e-08 35.3 0.0 1.8e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain zf-B_box PF00643.22 NM_015163.5_1 - 2.9e-06 27.2 8.3 2.9e-06 27.2 8.3 5.3 5 0 0 5 5 5 2 B-box zinc finger zf-C3HC4_3 PF13920.4 NM_015163.5_1 - 3.7e-06 26.6 1.8 3.7e-06 26.6 1.8 5.4 6 0 0 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_015163.5_1 - 1.6e-05 24.7 6.6 1.7e-05 24.6 3.6 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 NM_015163.5_1 - 6.1e-05 23.0 4.5 6.1e-05 23.0 4.5 4.3 5 0 0 5 5 5 1 zinc finger of C3HC4-type, RING PRY PF13765.4 NM_015163.5_1 - 0.00031 20.2 0.0 0.00077 18.9 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-RING_5 PF14634.4 NM_015163.5_1 - 0.00041 20.1 1.4 0.00041 20.1 1.4 4.8 4 0 0 4 4 4 1 zinc-RING finger domain Trm112p PF03966.14 NM_015163.5_1 - 5.3 7.6 7.5 17 6.0 0.1 3.3 2 1 0 2 2 2 0 Trm112p-like protein Ras PF00071.20 NM_001163989.1_2 - 6.2e-58 194.8 0.1 8.1e-58 194.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001163989.1_2 - 4.7e-31 107.4 0.1 7.3e-31 106.8 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001163989.1_2 - 1.6e-13 50.4 0.0 2.3e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_001163989.1_2 - 8.1e-05 21.9 0.0 0.00013 21.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 NM_001163989.1_2 - 0.029 14.3 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DAP3 PF10236.7 NM_001163989.1_2 - 0.087 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 zf-met PF12874.5 NM_001290004.1_3 - 1.2e-22 79.5 15.0 1.9e-08 34.3 1.8 3.3 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001290004.1_3 - 2.6e-15 56.2 13.0 6e-05 23.1 1.8 3.4 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 NM_001290004.1_3 - 9.9e-07 28.9 4.0 0.53 10.5 0.2 3.1 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.10 NM_001290004.1_3 - 0.0006 19.4 4.8 0.18 11.4 0.0 3.3 3 0 0 3 3 3 1 U1 zinc finger AKAP95 PF04988.10 NM_001290004.1_3 - 0.00086 19.4 2.8 0.7 10.0 0.1 3.1 3 0 0 3 3 3 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2 PF00096.24 NM_001290004.1_3 - 0.0016 18.7 9.0 0.56 10.6 0.2 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-DBF PF07535.10 NM_001290004.1_3 - 0.005 16.8 6.1 0.037 14.0 0.2 3.2 3 0 0 3 3 3 1 DBF zinc finger zf-C2H2_4 PF13894.4 NM_001290004.1_3 - 0.0063 17.1 3.8 1.5 9.7 0.3 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_9 PF16293.3 NM_001290004.1_3 - 0.12 12.1 3.6 9.1 6.1 0.1 3.1 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) DUF3449 PF11931.6 NM_001290004.1_3 - 0.22 11.2 1.0 10 5.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Actin_micro PF17003.3 NM_001290004.1_3 - 1.9 7.4 3.1 19 4.1 0.0 2.7 3 0 0 3 3 3 0 Putative actin-like family Sulfotransfer_1 PF00685.25 NM_001320878.1_1 - 3e-86 289.1 2.0 3.7e-86 288.8 2.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_001320878.1_1 - 6.2e-10 39.7 0.0 9.3e-07 29.3 0.0 2.3 2 0 0 2 2 2 2 Sulfotransferase family Fe_dep_repr_C PF02742.13 NM_001320878.1_1 - 0.057 13.4 0.1 0.17 11.8 0.1 1.8 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain FhuF_C PF11575.6 NM_001320878.1_3 - 0.04 13.7 0.4 0.04 13.7 0.4 2.8 3 0 0 3 3 3 0 FhuF 2Fe-2S C-terminal domain 7tm_1 PF00001.19 NM_001168298.1_1 - 2.4e-52 177.7 15.6 4.2e-52 176.9 15.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TrbC PF04956.11 NM_001168298.1_1 - 0.16 12.1 1.9 5.3 7.2 0.2 2.4 2 0 0 2 2 2 0 TrbC/VIRB2 family CCDC106 PF15794.3 NM_013301.2_1 - 3e-99 331.2 0.4 3.7e-99 330.9 0.4 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 106 MMS22L_N PF14910.4 NM_198468.2_3 - 0 1247.5 31.0 0 1247.2 31.0 1.1 1 0 0 1 1 1 1 S-phase genomic integrity recombination mediator, N-terminal MMS22L_C PF14911.4 NM_198468.2_3 - 6.4e-136 453.3 7.4 6.4e-136 453.3 7.4 2.7 3 0 0 3 3 3 1 S-phase genomic integrity recombination mediator, C-terminal SAM_1 PF00536.28 NM_033517.1_1 - 1.4e-20 73.3 0.1 2.4e-20 72.6 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank_2 PF12796.5 NM_033517.1_1 - 4e-20 72.1 4.2 2.6e-09 37.4 0.6 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_033517.1_1 - 1.9e-14 53.6 8.0 6.8e-07 29.6 0.4 5.7 1 1 5 6 6 6 5 Ankyrin repeats (many copies) SAM_2 PF07647.15 NM_033517.1_1 - 1e-12 47.8 0.1 1.9e-12 47.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) FERM_f0 PF16511.3 NM_033517.1_1 - 1.4e-11 44.4 0.0 2.3e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM SH3_2 PF07653.15 NM_033517.1_1 - 3e-11 42.7 0.2 7e-11 41.5 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain Ank_5 PF13857.4 NM_033517.1_1 - 8.2e-10 38.6 8.4 0.0014 18.8 0.5 4.5 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 NM_033517.1_1 - 4.5e-09 36.2 10.3 0.0016 18.7 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat SH3_9 PF14604.4 NM_033517.1_1 - 3.2e-08 33.1 0.0 6.2e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_3 PF13606.4 NM_033517.1_1 - 8e-08 31.8 4.7 0.82 10.3 0.0 6.8 6 0 0 6 6 6 2 Ankyrin repeat PDZ PF00595.22 NM_033517.1_1 - 2.2e-06 27.8 0.0 5.1e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_1 PF00018.26 NM_033517.1_1 - 3.1e-05 23.3 0.0 5.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain PAC2 PF09754.7 NM_147163.1_3 - 1e-33 117.0 0.0 1.3e-33 116.6 0.0 1.1 1 0 0 1 1 1 1 PAC2 family UCH PF00443.27 NM_001256869.1_1 - 1.5e-37 129.4 3.6 5.7e-37 127.5 1.4 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001256869.1_1 - 1.1e-11 44.8 3.0 1.7e-10 40.9 0.1 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase HABP4_PAI-RBP1 PF04774.13 NM_001256869.1_1 - 0.00039 21.1 0.6 0.00089 20.0 0.6 1.6 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family SAM_1 PF00536.28 NM_001304366.1_1 - 5.1e-13 49.1 0.0 7.7e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001304366.1_1 - 2.5e-10 40.2 0.0 4.6e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_001304366.1_1 - 0.042 13.7 0.0 0.097 12.5 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain CENP-W PF15510.4 NM_001286524.1_3 - 5.5e-47 157.8 1.1 8.5e-47 157.2 1.1 1.3 1 0 0 1 1 1 1 CENP-W protein PHD PF00628.27 NM_153812.2_3 - 9e-07 28.6 8.1 9e-07 28.6 8.1 2.4 3 0 0 3 3 3 1 PHD-finger PHD_2 PF13831.4 NM_153812.2_3 - 9.5e-06 24.9 4.8 4.5e-05 22.8 4.8 2.3 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.20 NM_153812.2_3 - 0.044 13.5 2.8 0.18 11.5 2.8 2.1 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H PF13771.4 NM_153812.2_3 - 0.67 10.1 4.8 0.28 11.3 1.9 1.9 2 0 0 2 2 2 0 PHD-like zinc-binding domain Defensin_propep PF00879.16 NM_001926.3_3 - 3.3e-22 78.4 14.2 1.2e-20 73.4 14.2 2.1 1 1 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 NM_001926.3_3 - 2.7e-07 30.9 15.5 5e-07 30.0 15.5 1.5 1 0 0 1 1 1 1 Mammalian defensin Defensin_beta_2 PF13841.4 NM_001926.3_3 - 0.11 12.9 8.8 0.24 11.8 8.8 1.6 1 1 0 1 1 1 0 Beta defensin SAPS PF04499.13 NM_001164162.1_1 - 6e-104 348.4 10.9 9.2e-66 222.5 5.2 3.4 3 1 1 4 4 4 2 SIT4 phosphatase-associated protein SNF PF00209.16 NM_001134368.3_2 - 1.1e-75 255.3 10.1 1.3e-75 254.9 10.1 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family AMP-binding PF00501.26 NM_025149.5_3 - 8.8e-97 324.2 0.0 1e-96 324.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 NM_025149.5_3 - 3.5e-17 63.0 0.7 7.1e-17 62.0 0.1 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Xlink PF00193.15 NM_001884.3_1 - 3.9e-61 203.3 0.0 5e-33 113.2 0.0 2.3 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.15 NM_001884.3_1 - 5.6e-09 36.0 0.0 1.1e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001884.3_1 - 0.00075 19.9 0.0 0.0016 18.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_001884.3_1 - 0.038 14.2 0.0 0.27 11.5 0.0 2.1 1 1 0 1 1 1 0 Immunoglobulin domain I-set PF07679.14 NM_001884.3_1 - 0.057 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain MIB_HERC2 PF06701.11 NM_001193623.1_1 - 0.027 14.6 0.1 0.053 13.7 0.1 1.4 1 0 0 1 1 1 0 Mib_herc2 SR-25 PF10500.7 NM_001193623.1_2 - 0.067 12.7 24.2 0.095 12.2 24.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.9 NM_001193623.1_2 - 0.7 10.0 20.1 1 9.5 20.1 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 RNA_polI_A34 PF08208.9 NM_001193623.1_2 - 4.3 7.3 27.1 6.5 6.7 27.1 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 CD20 PF04103.13 NM_001247999.1_3 - 9.9e-32 110.0 12.0 1.4e-31 109.6 12.0 1.2 1 0 0 1 1 1 1 CD20-like family Arm PF00514.21 NM_001286702.1_1 - 0.00016 21.4 0.0 0.00058 19.7 0.0 2.0 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat HMA PF00403.24 NM_001286702.1_3 - 0.044 14.1 0.0 0.085 13.2 0.0 1.4 1 0 0 1 1 1 0 Heavy-metal-associated domain Prokineticin PF06607.9 NM_001126128.1_2 - 1.7e-46 156.3 6.3 1.7e-46 156.3 6.3 2.6 4 0 0 4 4 4 1 Prokineticin ATG16 PF08614.9 NM_017974.3_3 - 6.7e-46 156.9 25.7 6.7e-46 156.9 25.7 1.6 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) WD40 PF00400.30 NM_017974.3_3 - 1.2e-31 108.1 12.7 2e-06 28.3 0.0 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_017974.3_3 - 4.7e-08 33.1 0.1 0.017 15.3 0.0 4.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_017974.3_3 - 2.3e-05 24.2 0.0 0.39 10.4 0.0 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 NM_017974.3_3 - 0.0025 16.4 0.4 1.7 7.1 0.0 3.1 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Phage_GPO PF05929.9 NM_017974.3_3 - 1.1 8.7 7.5 1.7 8.1 6.7 1.6 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase APG6 PF04111.10 NM_017974.3_3 - 2.5 7.3 19.4 4.2 6.6 19.4 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-RING_2 PF13639.4 NM_032173.3_1 - 5.5e-12 45.6 9.7 5.5e-12 45.6 9.7 2.8 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.3 NM_032173.3_1 - 3.7e-10 39.2 2.2 3.7e-10 39.2 2.2 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 NM_032173.3_1 - 1.8e-07 30.8 8.7 1.8e-07 30.8 8.7 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_032173.3_1 - 1.1e-06 28.3 8.1 6.2e-06 25.9 8.1 2.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_032173.3_1 - 8.5e-05 22.6 7.3 8.5e-05 22.6 7.3 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 NM_032173.3_1 - 0.00053 19.8 9.8 0.00074 19.4 5.6 3.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.4 NM_032173.3_1 - 0.0029 17.4 7.4 0.0029 17.4 7.4 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 NM_032173.3_1 - 0.0043 16.7 6.7 0.0043 16.7 6.7 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Pkinase_Tyr PF07714.15 NM_001010938.1_2 - 9.3e-87 290.5 0.0 1.2e-86 290.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase GTPase_binding PF09027.8 NM_001010938.1_2 - 1.5e-44 149.6 0.6 3e-44 148.7 0.6 1.5 1 0 0 1 1 1 1 GTPase binding Pkinase PF00069.23 NM_001010938.1_2 - 1.6e-41 142.3 0.0 2.7e-41 141.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Inhibitor_Mig-6 PF11555.6 NM_001010938.1_2 - 2.8e-25 88.0 19.1 2.8e-25 88.0 19.1 4.4 3 1 0 3 3 3 1 EGFR receptor inhibitor Mig-6 SH3_9 PF14604.4 NM_001010938.1_2 - 7.1e-11 41.7 0.0 1.4e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001010938.1_2 - 0.0001 21.7 0.0 0.00017 21.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain Kinase-like PF14531.4 NM_001010938.1_2 - 0.00014 21.1 0.0 0.00024 20.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SH3_2 PF07653.15 NM_001010938.1_2 - 0.00037 20.0 0.5 0.00083 18.9 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain UBA_4 PF14555.4 NM_001010938.1_2 - 0.03 14.0 0.0 0.056 13.1 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain GARS_A PF01071.17 NM_001136006.1_2 - 9.6e-92 306.0 0.0 2e-91 304.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.17 NM_001136006.1_2 - 1.2e-63 214.0 0.1 2.4e-63 213.0 0.1 1.6 1 0 0 1 1 1 1 Formyl transferase AIRS_C PF02769.20 NM_001136006.1_2 - 2.9e-40 137.8 0.5 1.9e-39 135.2 0.0 2.6 3 0 0 3 3 3 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.13 NM_001136006.1_2 - 5e-35 120.0 0.6 4.5e-34 117.0 0.2 2.7 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.14 NM_001136006.1_2 - 7.8e-27 93.3 0.4 3.7e-26 91.1 0.2 2.4 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.22 NM_001136006.1_2 - 3.8e-16 59.4 0.4 1.5e-15 57.5 0.4 2.1 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATPgrasp_Ter PF15632.4 NM_001136006.1_2 - 2.4e-07 29.6 0.5 7.4e-07 28.0 0.2 1.9 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.20 NM_001136006.1_2 - 0.00016 21.2 0.0 0.00035 20.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.15 NM_001136006.1_2 - 0.00017 21.0 0.9 0.00042 19.7 0.1 2.1 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_2 PF08442.8 NM_001136006.1_2 - 0.00065 19.2 0.1 0.0019 17.7 0.1 1.7 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.4 NM_001136006.1_2 - 0.0014 18.1 0.1 0.0029 17.1 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.12 NM_001136006.1_2 - 0.0015 18.5 0.0 0.0047 16.9 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.11 NM_001136006.1_2 - 0.0077 15.6 0.0 0.017 14.5 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus DUF498 PF04430.12 NM_001136006.1_2 - 0.033 14.1 0.1 1.9 8.5 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF498/DUF598) Sacchrp_dh_NADP PF03435.16 NM_001136006.1_2 - 0.045 13.9 0.0 0.16 12.1 0.0 2.0 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain RimK PF08443.9 NM_001136006.1_2 - 0.065 12.7 0.1 0.24 10.8 0.0 1.9 2 0 0 2 2 2 0 RimK-like ATP-grasp domain EF-hand_7 PF13499.4 NM_001128826.1_1 - 5.7e-23 81.0 2.5 1e-16 61.0 0.4 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_001128826.1_1 - 2.4e-20 70.4 5.1 4.3e-06 25.8 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 NM_001128826.1_1 - 2.1e-18 64.5 3.3 0.00014 21.4 0.1 4.6 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.4 NM_001128826.1_1 - 3.5e-14 51.4 4.4 0.00057 19.2 0.3 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 NM_001128826.1_1 - 3.5e-10 39.4 3.0 0.00071 19.2 0.1 3.3 1 1 2 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_001128826.1_1 - 0.055 13.7 0.4 1.3 9.2 0.1 2.6 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.4 NM_001128826.1_1 - 0.17 12.1 0.0 0.58 10.4 0.0 1.9 1 1 1 2 2 2 0 EF-hand domain EF-hand_4 PF12763.5 NM_001128826.1_1 - 0.51 10.2 1.5 10 6.0 0.5 2.8 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand MARVEL PF01284.21 NM_181270.2_1 - 0.056 13.3 9.8 0.12 12.2 9.9 1.5 1 1 0 1 1 1 0 Membrane-associating domain MHYT PF03707.14 NM_181270.2_1 - 3.9 7.6 6.8 1.7 8.7 0.1 2.9 1 1 1 2 2 2 0 Bacterial signalling protein N terminal repeat Hep_59 PF07052.9 NM_016520.2_1 - 2.8e-29 101.8 2.8 2.8e-29 101.8 2.8 2.7 3 0 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 Cation_efflux PF01545.19 NM_001172815.2_3 - 2.7e-42 144.6 16.6 4.4e-42 143.9 16.6 1.3 1 0 0 1 1 1 1 Cation efflux family zf-H2C2_2 PF13465.4 NM_001322914.1_1 - 2.4e-96 312.1 97.9 2e-08 34.2 1.4 15.8 15 0 0 15 15 15 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001322914.1_1 - 1.1e-80 261.7 126.2 8.6e-07 29.0 1.0 16.2 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001322914.1_1 - 5.6e-44 144.8 114.5 0.00039 20.9 1.8 16.0 16 0 0 16 16 15 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001322914.1_1 - 2.5e-25 87.7 95.7 0.00095 18.9 0.4 14.5 14 0 0 14 14 14 12 C2H2-type zinc finger KRAB PF01352.25 NM_001322914.1_1 - 2.8e-23 81.2 0.4 6.4e-23 80.0 0.4 1.7 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001322914.1_1 - 4e-16 58.7 65.8 0.00024 21.0 1.5 9.1 3 2 6 10 10 10 9 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_001322914.1_1 - 5.6e-06 26.9 63.0 0.64 10.7 1.7 8.0 1 1 5 7 7 7 6 zinc-ribbon family DUF3268 PF11672.6 NM_001322914.1_1 - 2.2e-05 24.7 51.7 0.4 10.9 1.3 7.6 1 1 2 8 8 8 6 zinc-finger-containing domain C1_1 PF00130.20 NM_001322914.1_1 - 0.00017 21.2 61.7 0.22 11.3 1.5 9.9 3 1 7 10 10 10 4 Phorbol esters/diacylglycerol binding domain (C1 domain) CpXC PF14353.4 NM_001322914.1_1 - 0.0004 20.3 60.2 3.9 7.4 0.1 13.2 7 4 4 11 11 11 3 CpXC protein GATA PF00320.25 NM_001322914.1_1 - 0.001 18.5 53.0 1.2 8.6 0.1 12.5 12 2 1 13 13 13 3 GATA zinc finger Zn_Tnp_IS1595 PF12760.5 NM_001322914.1_1 - 0.011 15.5 4.2 0.011 15.5 4.2 9.6 5 2 6 12 12 12 0 Transposase zinc-ribbon domain PHD PF00628.27 NM_001322914.1_1 - 0.015 15.0 2.1 0.015 15.0 2.1 8.5 5 2 1 8 8 8 0 PHD-finger FYVE PF01363.19 NM_001322914.1_1 - 0.072 13.1 63.6 0.67 10.0 8.9 6.4 4 2 0 4 4 4 0 FYVE zinc finger zf-LYAR PF08790.9 NM_001322914.1_1 - 0.44 10.3 62.0 2.7 7.8 0.2 14.7 15 0 0 15 15 15 0 LYAR-type C2HC zinc finger ADK_lid PF05191.12 NM_001322914.1_1 - 0.55 10.2 54.9 0.035 14.0 2.5 9.3 5 3 5 10 10 10 0 Adenylate kinase, active site lid C1_4 PF07975.10 NM_001322914.1_1 - 0.59 10.3 66.0 3.2 8.0 2.1 9.6 2 2 7 11 11 11 0 TFIIH C1-like domain FYDLN_acid PF09538.8 NM_001322914.1_1 - 0.76 10.3 37.4 32 5.1 0.1 11.2 2 2 8 10 10 10 0 Protein of unknown function (FYDLN_acid) zf-C2H2_jaz PF12171.6 NM_001322914.1_1 - 1.6 9.0 67.5 1.6 9.0 0.1 12.4 12 0 0 12 12 12 0 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001322914.1_1 - 1.8 8.5 72.1 5.3 7.0 0.0 14.4 16 0 0 16 16 15 0 XPA protein N-terminal HypA PF01155.17 NM_001322914.1_1 - 3.3 7.6 58.2 5.3 7.0 5.5 7.8 1 1 6 7 7 7 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA YhfH PF14149.4 NM_001322914.1_1 - 4 7.4 61.5 25 4.8 0.2 13.2 13 0 0 13 13 13 0 YhfH-like protein Chordopox_RPO7 PF05864.10 NM_001322914.1_1 - 8.7 6.5 13.3 13 6.0 0.0 6.9 9 0 0 9 9 8 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Pkinase PF00069.23 NM_001282645.1_1 - 5.8e-63 212.6 0.0 8e-63 212.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001282645.1_1 - 1.1e-40 139.4 0.0 1.9e-40 138.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 NM_001282645.1_1 - 5.5e-32 109.3 21.8 5.6e-17 61.2 6.1 2.9 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 NM_001282645.1_1 - 8.3e-09 35.9 0.8 1.5e-08 35.1 0.8 1.4 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_001282645.1_1 - 0.00016 20.9 0.0 0.00083 18.6 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Zf_RING PF16744.3 NM_001282645.1_1 - 0.0056 16.6 10.8 0.009 16.0 2.7 2.9 2 0 0 2 2 2 1 KIAA1045 RING finger C1_2 PF03107.14 NM_001282645.1_1 - 0.022 14.9 24.9 0.03 14.5 6.4 3.4 3 0 0 3 3 3 0 C1 domain APH PF01636.21 NM_001282645.1_1 - 0.039 13.7 0.0 0.13 12.0 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family DZR PF12773.5 NM_001282645.1_1 - 0.064 13.2 15.0 0.11 12.4 2.9 2.7 2 0 0 2 2 2 0 Double zinc ribbon PHD_2 PF13831.4 NM_001282645.1_1 - 0.45 10.0 11.3 1.9 7.9 1.7 3.2 2 0 0 2 2 2 0 PHD-finger PHD PF00628.27 NM_001282645.1_1 - 0.45 10.3 25.9 0.11 12.2 6.6 3.8 3 0 0 3 3 3 0 PHD-finger DUF2318 PF10080.7 NM_001282645.1_1 - 7.5 6.6 12.5 1.1 9.2 2.7 2.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) LRR_9 PF14580.4 NM_032024.4_3 - 2.1e-12 46.7 2.7 2.1e-12 46.7 2.7 2.2 2 1 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 NM_032024.4_3 - 3.4e-07 30.3 16.6 1e-05 25.6 6.2 4.0 2 1 2 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_032024.4_3 - 0.021 14.4 14.9 0.21 11.3 2.5 3.1 3 1 0 3 3 3 0 Leucine rich repeat LRR_6 PF13516.4 NM_032024.4_3 - 0.78 9.8 6.3 11 6.2 0.3 3.6 3 0 0 3 3 3 0 Leucine Rich repeat Band_7 PF01145.23 NM_001318875.1_1 - 6.8e-09 35.9 0.9 6.3e-06 26.2 0.1 3.8 2 2 2 4 4 4 2 SPFH domain / Band 7 family Flot PF15975.3 NM_001318875.1_1 - 4.8e-07 29.9 8.4 4.8e-07 29.9 8.4 3.6 2 2 2 4 4 4 2 Flotillin DUF4711 PF15829.3 NM_001321399.1_3 - 7.1e-65 218.9 0.2 1e-64 218.4 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4711) His_Phos_1 PF00300.20 NM_138575.3_2 - 4.2e-11 42.8 0.2 1.5e-09 37.7 0.2 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Granulin PF00396.16 NM_138575.3_3 - 0.035 14.3 0.3 0.035 14.3 0.3 2.2 2 0 0 2 2 2 0 Granulin Alpha-amylase_C PF02806.16 NM_001008218.1_3 - 6e-15 55.3 0.1 1.3e-14 54.2 0.1 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.22 NM_001008218.1_3 - 1.8e-12 47.3 0.0 3.3e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Med8 PF10232.7 NM_001001653.2_2 - 2.2e-77 259.6 0.1 3e-77 259.2 0.1 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Baculo_PEP_C PF04513.10 NM_001001653.2_2 - 0.022 14.6 0.2 4.5 7.2 0.2 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-Q PF13094.4 NM_001001653.2_2 - 1.1 9.2 5.2 2.2 8.3 1.6 2.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DENN PF02141.19 NM_130476.2_3 - 3.5e-33 115.0 2.4 8e-33 113.8 2.4 1.6 1 1 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 NM_130476.2_3 - 3.6e-18 66.0 0.6 1.1e-17 64.5 0.6 1.9 1 0 0 1 1 1 1 uDENN domain DAGK_acc PF00609.17 NM_001321710.1_2 - 6.3e-47 159.7 0.0 9.8e-47 159.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 NM_001321710.1_2 - 2.6e-28 98.0 0.0 4.4e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 NM_001321710.1_2 - 2.3e-13 49.7 27.6 1.4e-10 40.8 16.1 3.0 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_2 PF12796.5 NM_001321710.1_2 - 3.9e-12 46.4 0.1 7.9e-12 45.5 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_001321710.1_2 - 7.1e-07 28.9 0.1 0.023 15.1 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 NM_001321710.1_2 - 9.8e-07 28.8 0.0 0.04 14.2 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_001321710.1_2 - 1.5e-06 28.5 0.0 9.9e-06 25.9 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 NM_001321710.1_2 - 8.6e-06 25.9 1.8 0.082 13.3 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat HS1_rep PF02218.13 NM_005231.3_3 - 2.5e-127 414.9 77.2 6.5e-21 74.4 2.7 7.6 7 0 0 7 7 7 7 Repeat in HS1/Cortactin SH3_9 PF14604.4 NM_005231.3_3 - 6.6e-17 61.0 0.2 1.5e-16 59.9 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_005231.3_3 - 4.9e-16 57.9 0.2 1.3e-15 56.6 0.2 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_005231.3_3 - 1.7e-09 37.1 0.0 3.5e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.4 NM_005231.3_3 - 2.9e-06 27.5 7.4 11 6.4 0.0 6.7 1 1 6 7 7 7 2 TMEM210 family FadA PF09403.8 NM_005231.3_3 - 0.057 13.8 8.4 0.13 12.6 8.4 1.5 1 0 0 1 1 1 0 Adhesion protein FadA MCU PF04678.11 NM_005231.3_3 - 1 9.3 3.9 2.3 8.2 3.9 1.5 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Casc1_N PF15927.3 NM_005231.3_3 - 4.2 6.8 16.3 7.8 6.0 16.3 1.3 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Hydin_ADK PF17213.1 NM_005231.3_3 - 9.1 6.4 7.2 22 5.1 7.2 1.6 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain ATP-synt_C PF00137.19 NM_001002258.4_1 - 4.3e-10 39.6 12.4 4.3e-10 39.6 12.4 1.9 2 0 0 2 2 2 1 ATP synthase subunit C IGFL PF14653.4 NM_207393.1_2 - 1.6e-43 146.5 10.8 2.5e-43 145.8 10.8 1.3 1 0 0 1 1 1 1 Insulin growth factor-like family Carb_bind PF10645.7 NM_207393.1_2 - 0.2 11.8 8.0 0.49 10.5 8.0 1.7 1 0 0 1 1 1 0 Carbohydrate binding Dynamin_M PF01031.18 NM_001005361.2_2 - 5.5e-111 370.2 3.5 7e-111 369.9 2.2 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.21 NM_001005361.2_2 - 1.8e-55 187.4 0.0 4.3e-55 186.2 0.0 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.16 NM_001005361.2_2 - 1.7e-25 88.9 4.5 2.1e-25 88.6 2.8 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain PH PF00169.27 NM_001005361.2_2 - 1.2e-13 51.3 0.6 2.4e-13 50.4 0.6 1.5 1 0 0 1 1 1 1 PH domain MMR_HSR1 PF01926.21 NM_001005361.2_2 - 8.3e-05 22.5 0.1 0.001 19.0 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase PH_11 PF15413.4 NM_001005361.2_2 - 0.61 10.4 2.6 1.1 9.6 1.3 2.1 2 1 0 2 2 2 0 Pleckstrin homology domain Jnk-SapK_ap_N PF09744.7 NM_001005361.2_2 - 6.4 6.8 7.1 0.64 10.1 0.2 2.7 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 RabGAP-TBC PF00566.16 NM_001291459.1_1 - 1.1e-37 129.7 0.0 1.5e-37 129.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain TMEM117 PF15113.4 NM_001286212.1_1 - 1.1e-131 439.5 7.2 1.8e-131 438.7 7.2 1.3 1 0 0 1 1 1 1 TMEM117 protein family TMEM117 PF15113.4 NM_001286212.1_2 - 3.1e-70 237.1 10.9 4.2e-70 236.6 10.9 1.1 1 0 0 1 1 1 1 TMEM117 protein family Death PF00531.20 NM_001170700.2_2 - 1.7e-10 40.8 1.7 1.7e-10 40.8 1.7 1.9 2 0 0 2 2 2 1 Death domain ZU5 PF00791.18 NM_001170700.2_2 - 0.0022 18.2 0.1 0.25 11.6 0.0 2.7 2 0 0 2 2 2 1 ZU5 domain GD_AH_C PF04295.11 NM_001170700.2_2 - 0.011 14.5 2.1 0.016 13.9 2.1 1.1 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus DED PF01335.19 NM_001170700.2_2 - 0.014 15.6 1.1 0.035 14.2 1.1 1.7 1 0 0 1 1 1 0 Death effector domain DUF2314 PF10077.7 NM_001170700.2_2 - 0.39 10.6 3.0 0.46 10.4 0.9 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2314) WD40 PF00400.30 NM_003939.4_2 - 8.5e-36 121.2 18.1 8.6e-06 26.3 0.2 8.0 7 0 0 7 7 7 7 WD domain, G-beta repeat Beta-TrCP_D PF12125.6 NM_003939.4_2 - 1.3e-23 82.5 3.4 2.6e-23 81.5 3.4 1.6 1 0 0 1 1 1 1 D domain of beta-TrCP F-box-like PF12937.5 NM_003939.4_2 - 5.1e-10 38.9 0.1 1.7e-09 37.3 0.1 1.9 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.5 NM_003939.4_2 - 1.5e-07 31.5 1.7 0.12 12.5 0.1 4.0 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.31 NM_003939.4_2 - 2.3e-06 27.2 0.5 1e-05 25.1 0.0 2.4 2 0 0 2 2 2 1 F-box domain WD40_like PF17005.3 NM_003939.4_2 - 0.00013 21.3 0.4 0.021 14.0 0.3 2.2 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.6 NM_003939.4_2 - 0.0011 17.5 7.3 0.44 9.0 0.1 3.7 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Ribosomal_L32e PF01655.16 NM_000994.3_2 - 9.1e-60 199.6 2.6 1.3e-59 199.1 2.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L32 zf-H2C2_2 PF13465.4 NM_001267779.1_1 - 1.4e-226 723.8 236.5 4.2e-09 36.3 0.6 34.2 34 0 0 34 34 34 31 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001267779.1_1 - 1.7e-132 424.8 253.1 1.4e-05 25.1 0.5 34.0 34 0 0 34 34 34 30 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001267779.1_1 - 3.2e-66 214.1 236.8 0.0033 18.0 1.8 33.3 33 0 0 33 33 32 29 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001267779.1_1 - 1.1e-54 181.3 194.6 0.00065 19.5 0.3 31.2 30 0 0 30 30 30 27 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001267779.1_1 - 2.2e-33 114.0 160.4 0.0031 17.5 1.1 18.7 8 3 9 20 20 20 19 Zinc ribbon domain KRAB PF01352.25 NM_001267779.1_1 - 2e-21 75.2 1.3 3.3e-21 74.6 1.3 1.4 1 0 0 1 1 1 1 KRAB box zf-met PF12874.5 NM_001267779.1_1 - 1.5e-12 47.4 175.8 0.023 15.0 0.5 26.0 26 1 0 26 26 26 12 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001267779.1_1 - 1.9e-10 40.6 136.6 0.19 12.0 0.4 26.6 30 0 0 30 30 28 10 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 NM_001267779.1_1 - 1.7e-07 30.8 143.6 0.73 9.6 0.5 27.2 27 3 0 27 27 27 8 Probable zinc-ribbon domain zf-C2H2_11 PF16622.3 NM_001267779.1_1 - 9e-06 25.2 186.7 0.09 12.4 0.1 29.0 31 0 0 31 31 30 12 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_001267779.1_1 - 0.0018 18.9 124.2 0.14 12.8 0.9 16.2 6 4 9 16 16 16 7 zinc-ribbon family XPA_N PF01286.16 NM_001267779.1_1 - 0.0092 15.9 139.3 3.3 7.7 0.2 29.0 30 0 0 30 30 30 1 XPA protein N-terminal Ribosomal_L7Ae PF01248.24 NM_001037290.2_1 - 8.7e-08 31.7 0.2 1.4e-07 31.0 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RPE65 PF03055.13 NM_001037290.2_3 - 2e-112 376.3 0.0 2.4e-112 376.0 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein RRM_1 PF00076.20 NM_138962.3_3 - 1.4e-32 111.2 0.3 6.5e-16 57.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_138962.3_3 - 2.2e-08 33.9 0.1 0.011 15.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif Quaking_NLS PF16551.3 NM_138962.3_3 - 1.1 8.9 2.6 21 4.8 0.0 2.3 2 0 0 2 2 2 0 Putative nuclear localisation signal of quaking Vps26 PF03643.13 NM_001318946.1_2 - 1.1e-104 349.2 4.0 1.5e-104 348.7 4.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Vps26 PF03643.13 NM_001318946.1_3 - 2.9e-08 32.9 0.0 4e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 ABC_membrane PF00664.21 NM_001271699.1_3 - 4e-37 128.2 9.6 6.2e-37 127.6 9.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 NM_001271699.1_3 - 1.1e-33 116.5 0.0 2.2e-33 115.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 NM_001271699.1_3 - 3.3e-05 23.3 0.1 0.0077 15.5 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 NM_001271699.1_3 - 0.00074 19.8 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.4 NM_001271699.1_3 - 0.0033 17.0 0.3 0.011 15.3 0.3 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF87 PF01935.15 NM_001271699.1_3 - 0.011 15.6 0.1 0.027 14.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_22 PF13401.4 NM_001271699.1_3 - 0.077 13.1 0.0 0.23 11.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.4 NM_001271699.1_3 - 0.1 12.7 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 NM_001271699.1_3 - 0.11 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF697 PF05128.10 NM_001271699.1_3 - 0.18 11.4 2.5 0.8 9.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF697) AAA_23 PF13476.4 NM_001271699.1_3 - 0.25 11.7 1.2 1.2 9.5 0.1 2.2 2 0 0 2 2 2 0 AAA domain adh_short PF00106.23 NM_004051.4_2 - 5.2e-41 140.1 0.0 7.2e-41 139.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_004051.4_2 - 5.6e-25 88.1 0.0 8.6e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_004051.4_2 - 2.5e-06 27.4 0.0 3.9e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.8 NM_004051.4_2 - 0.00065 19.0 0.0 0.0018 17.6 0.0 1.6 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) WT1 PF02165.13 NM_004051.4_2 - 0.0026 16.9 6.9 0.0039 16.3 6.9 1.2 1 0 0 1 1 1 1 Wilm's tumour protein LIAS_N PF16881.3 NM_001278590.1_2 - 9.4e-51 170.7 0.1 1.8e-50 169.7 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.19 NM_001278590.1_2 - 1.4e-08 35.1 0.0 0.002 18.4 0.0 2.4 1 1 1 2 2 2 2 Radical SAM superfamily ROS_MUCR PF05443.9 NM_001278590.1_2 - 0.069 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein DPPIV_N PF00930.19 NM_001178034.1_1 - 1.8e-111 372.2 1.4 2.3e-111 371.8 1.4 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 NM_001178034.1_1 - 1.2e-46 158.8 0.0 1.7e-46 158.3 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.16 NM_001178034.1_1 - 3.8e-06 26.5 0.1 1.6e-05 24.4 0.1 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family PD40 PF07676.10 NM_001178034.1_1 - 0.01 15.6 0.3 3.8 7.4 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Abhydrolase_2 PF02230.14 NM_001178034.1_1 - 0.049 13.3 0.5 0.1 12.3 0.5 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.6 NM_001178034.1_1 - 0.11 11.6 0.2 5.6 6.0 0.1 2.2 1 1 1 2 2 2 0 Serine aminopeptidase, S33 Str_synth PF03088.14 NM_001178034.1_1 - 0.15 12.1 0.3 2.5 8.1 0.0 2.9 3 0 0 3 3 3 0 Strictosidine synthase Collagen PF01391.16 NM_133455.3_2 - 3.6e-22 77.7 133.6 2.5e-09 36.6 31.5 5.8 5 2 2 7 7 7 4 Collagen triple helix repeat (20 copies) EMI PF07546.11 NM_133455.3_2 - 1.4e-14 54.5 10.2 2.4e-14 53.7 10.2 1.4 1 0 0 1 1 1 1 EMI domain NPIP PF06409.9 NM_198495.2_2 - 0.02 14.0 6.2 0.045 12.8 6.2 1.6 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) DUF1664 PF07889.10 NM_198495.2_2 - 2.9 7.8 20.1 1.1 9.1 3.5 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Glyco_transf_29 PF00777.16 NM_003034.3_3 - 2.1e-76 256.7 0.0 2.8e-76 256.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) LRR_8 PF13855.4 NM_001146006.1_1 - 2e-120 392.5 91.8 1.9e-16 59.4 0.2 10.3 2 1 11 13 13 13 12 Leucine rich repeat LRR_4 PF12799.5 NM_001146006.1_1 - 2.8e-38 129.0 35.1 0.00016 21.9 0.0 11.7 7 3 6 13 13 13 13 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_001146006.1_1 - 1.1e-18 67.3 0.0 0.00013 21.8 0.0 4.1 1 1 3 4 4 4 4 Leucine rich repeats (6 copies) LRR_1 PF00560.31 NM_001146006.1_1 - 8.3e-14 49.8 49.7 5.9 7.6 0.3 18.2 19 1 0 19 19 19 3 Leucine Rich Repeat LRRNT PF01462.16 NM_001146006.1_1 - 1.8e-09 36.9 1.5 1.8e-09 36.9 1.5 3.8 5 0 0 5 5 5 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 NM_001146006.1_1 - 5.7e-07 29.1 26.1 0.016 14.6 0.1 5.9 2 1 3 6 6 6 5 Leucine-rich repeat SR-25 PF10500.7 NM_001146006.1_3 - 0.053 13.0 22.9 0.079 12.4 22.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2365 PF10157.7 NM_017622.2_2 - 8.8e-50 168.7 0.0 1.2e-49 168.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2365) SHNi-TPR PF10516.7 NM_152298.3_1 - 9.5e-15 53.7 5.8 1.7e-14 52.9 1.9 2.5 2 0 0 2 2 2 1 SHNi-TPR TPR_2 PF07719.15 NM_152298.3_1 - 7.4e-10 38.0 2.0 0.0026 17.6 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 NM_152298.3_1 - 1.2e-09 37.4 1.6 3.5e-05 23.3 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_152298.3_1 - 3.7e-09 36.6 8.3 2.2e-08 34.1 3.3 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.4 NM_152298.3_1 - 0.00011 22.0 2.1 0.041 14.0 0.1 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_152298.3_1 - 0.006 17.1 0.9 16 6.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_152298.3_1 - 0.0086 15.6 4.4 16 5.1 1.5 4.6 2 1 2 4 4 4 1 TPR repeat TPR_6 PF13174.4 NM_152298.3_1 - 0.0095 16.4 1.2 15 6.4 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_152298.3_1 - 0.031 15.0 0.4 7.6 7.5 0.0 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat SlyX PF04102.10 NM_152298.3_1 - 1.3 9.6 7.9 0.069 13.7 1.6 2.2 2 0 0 2 2 2 0 SlyX RRM_1 PF00076.20 NM_002138.3_1 - 2.8e-35 119.8 0.4 9.1e-17 60.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_002138.3_1 - 1.1e-17 63.8 0.7 2.9e-08 33.6 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif CBFNT PF08143.9 NM_002138.3_1 - 1e-12 49.1 27.6 1e-12 49.1 27.6 2.8 3 0 0 3 3 3 1 CBFNT (NUC161) domain RRM_3 PF08777.9 NM_002138.3_1 - 3.4e-05 23.7 0.5 0.085 12.8 0.1 2.5 2 1 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.4 NM_002138.3_1 - 0.00053 19.8 0.0 0.17 11.8 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif NID PF07292.11 NM_002138.3_1 - 0.0077 16.7 0.6 0.074 13.6 0.0 2.3 2 1 0 2 2 2 1 Nmi/IFP 35 domain (NID) Pkinase_Tyr PF07714.15 NM_153831.3_2 - 1.6e-93 312.6 0.0 2.4e-93 312.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.11 NM_153831.3_2 - 4.6e-56 188.3 2.3 9e-56 187.3 2.3 1.5 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.23 NM_153831.3_2 - 9.8e-46 156.1 0.0 1.7e-45 155.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 NM_153831.3_2 - 8.2e-11 42.2 0.2 3.9e-10 40.0 0.2 2.2 2 0 0 2 2 2 1 FERM central domain Kinase-like PF14531.4 NM_153831.3_2 - 0.0083 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like ERG2_Sigma1R PF04622.10 NM_001282209.1_1 - 4.9e-17 61.8 0.0 6.8e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein NADH_dehy_S2_C PF06444.9 NM_001282209.1_1 - 0.058 13.8 0.2 0.19 12.1 0.2 1.8 1 1 0 1 1 1 0 NADH dehydrogenase subunit 2 C-terminus ERG2_Sigma1R PF04622.10 NM_001282209.1_2 - 6.7e-16 58.1 0.0 9.6e-16 57.6 0.0 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Far-17a_AIG1 PF04750.12 NM_032744.3_1 - 8.5e-63 211.2 14.2 1.2e-62 210.7 14.2 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein RHD_dimer PF16179.3 NM_173165.2_2 - 2.7e-24 85.0 0.0 5e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.20 NM_173165.2_2 - 2.5e-22 79.5 0.1 2.5e-22 79.5 0.1 2.4 3 1 0 3 3 3 1 Rel homology DNA-binding domain TIG PF01833.22 NM_173165.2_2 - 0.00015 21.7 0.0 0.00049 20.0 0.0 2.0 1 0 0 1 1 1 1 IPT/TIG domain PaaSYMP PF14738.4 NM_033364.3_3 - 3.6e-64 215.3 12.3 3.6e-64 215.3 12.3 3.4 2 1 1 3 3 3 1 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1 TANGO2 PF05742.10 NM_001322143.1_2 - 5e-67 226.5 0.0 2e-66 224.5 0.0 1.8 2 0 0 2 2 2 1 Transport and Golgi organisation 2 MBF1 PF08523.8 NM_153200.2_1 - 1.9e-25 88.9 6.8 3.7e-25 88.0 6.8 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.20 NM_153200.2_1 - 4.3e-12 45.8 0.1 6.5e-12 45.2 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.4 NM_153200.2_1 - 8.9e-05 22.6 0.0 0.0002 21.5 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.5 NM_153200.2_1 - 0.057 13.4 0.0 0.085 12.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_38 PF13936.4 NM_153200.2_1 - 0.11 12.2 0.1 0.66 9.7 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HSNSD PF12062.6 NM_022569.2_2 - 1.1e-245 815.9 0.1 1.4e-245 815.6 0.1 1.1 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.25 NM_022569.2_2 - 1.3e-42 146.0 0.0 2.2e-42 145.3 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_022569.2_2 - 6.1e-08 33.2 0.3 0.00053 20.3 0.0 2.4 1 1 1 2 2 2 2 Sulfotransferase family NAD_Gly3P_dh_N PF01210.21 NM_015141.3_1 - 2e-51 173.9 0.6 3.4e-51 173.2 0.6 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.12 NM_015141.3_1 - 2e-49 167.4 0.2 3.2e-49 166.7 0.2 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.15 NM_015141.3_1 - 0.14 12.6 0.2 1.7 9.2 0.2 2.4 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent SYS1 PF09801.7 NM_001010876.1_3 - 0.00076 19.6 11.6 0.0011 19.0 11.6 1.2 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network # # Program: hmmscan # Version: 3.1b2 (February 2015) # Pipeline mode: SCAN # Query file: /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/refseq_human/wd/refseq_human_5000.p.fa # Target file: /home/yduan/database/Pfam/Pfam-A.hmm # Option settings: hmmscan -o /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/refseq_human/hmmscan.outm --tblout /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/refseq_human/hmmscan.t.out /home/yduan/database/Pfam/Pfam-A.hmm /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/refseq_human/wd/refseq_human_5000.p.fa # Current dir: /home/yduan/work_file/lncRNAdb/methods_assement # Date: Thu Jun 28 14:48:56 2018 # [ok]