# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- zf-C2H2_jaz PF12171.6 NM_028412.2_2 - 4.7e-07 29.8 10.3 2.4e-06 27.6 0.4 4.4 4 1 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 NM_028412.2_2 - 7.4e-05 22.9 15.8 0.0067 16.6 0.9 4.0 3 1 1 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.4 NM_028412.2_2 - 0.00057 20.4 19.3 0.088 13.6 0.4 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_028412.2_2 - 0.0026 18.0 16.9 0.46 10.9 0.9 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-U1 PF06220.10 NM_028412.2_2 - 0.33 10.6 11.2 3.7 7.3 3.0 3.4 3 0 0 3 3 3 0 U1 zinc finger AKAP95 PF04988.10 NM_028412.2_2 - 3.8 7.6 20.8 7.3 6.7 8.8 4.0 3 1 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) UCH PF00443.27 NM_001168372.2_3 - 1.7e-76 257.0 0.0 2.4e-76 256.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP19_linker PF16602.3 NM_001168372.2_3 - 4.3e-58 195.0 7.9 4.3e-58 195.0 7.9 2.4 2 0 0 2 2 2 1 Linker region of USP19 deubiquitinase UCH_1 PF13423.4 NM_001168372.2_3 - 2e-19 70.2 0.0 7.9e-09 35.4 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase CS PF04969.14 NM_001168372.2_3 - 2.1e-17 63.8 0.0 4.2e-13 50.0 0.0 2.5 2 0 0 2 2 2 2 CS domain zf-MYND PF01753.16 NM_001168372.2_3 - 2.3e-07 30.6 16.5 2.3e-07 30.6 16.5 3.1 5 0 0 5 5 5 1 MYND finger USP7_C2 PF14533.4 NM_001168372.2_3 - 0.013 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal Spin-Ssty PF02513.15 NM_001017393.3_3 - 6.3e-57 189.0 10.3 4e-22 77.6 0.1 3.3 3 0 0 3 3 3 3 Spin/Ssty Family TSNAXIP1_N PF15739.3 NM_025851.3_2 - 1.5e-32 112.2 1.1 1.5e-32 112.2 1.1 3.2 3 0 0 3 3 3 1 Translin-associated factor X-interacting N-terminus Lge1 PF11488.6 NM_025851.3_2 - 2.5 8.6 7.0 44 4.6 6.5 3.0 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 START PF01852.17 NM_001289648.1_3 - 3.9e-26 91.6 0.0 5.8e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 START domain PLAC8 PF04749.15 NM_139198.2_1 - 2.2e-13 50.9 20.9 3.7e-13 50.2 20.9 1.4 1 0 0 1 1 1 1 PLAC8 family Zip PF02535.20 NM_001135152.1_3 - 5.3e-66 223.0 8.6 9.6e-66 222.1 8.6 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter LSM PF01423.20 NM_026095.4_1 - 1.8e-15 56.2 0.2 2.5e-15 55.8 0.2 1.2 1 0 0 1 1 1 1 LSM domain Pkinase PF00069.23 NM_001164198.1_2 - 8.6e-72 241.5 0.0 1.1e-71 241.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001164198.1_2 - 2.7e-33 115.2 0.0 3.8e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001164198.1_2 - 2.4e-07 30.2 0.1 6.1e-07 28.9 0.0 1.6 2 0 0 2 2 2 1 Kinase-like DUF3538 PF12057.6 NM_001252468.1_2 - 9.5e-43 144.4 0.6 2.3e-42 143.2 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3538) ubiquitin PF00240.21 NM_001252468.1_2 - 6.3e-16 57.7 0.2 1e-15 57.1 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 NM_001252468.1_2 - 5.5e-05 22.8 0.2 0.0001 21.9 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 NM_001252468.1_2 - 0.015 15.7 0.0 0.11 13.0 0.0 2.3 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.4 NM_001252468.1_2 - 0.026 14.5 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2476 PF10630.7 NM_001134660.1_1 - 1e-92 310.8 24.1 1.2e-92 310.6 24.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2476) VitD-bind_III PF09164.8 NM_001134660.1_2 - 0.29 11.0 3.5 0.66 9.9 3.5 1.6 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Pannexin_like PF12534.6 NM_177725.4_2 - 5.6e-144 479.4 3.1 7.7e-144 479.0 3.1 1.2 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.4 NM_177725.4_2 - 2e-27 94.6 39.7 1.3e-09 37.5 1.3 6.7 5 2 0 6 6 6 4 Leucine rich repeat LRR_4 PF12799.5 NM_177725.4_2 - 4.8e-25 87.0 43.3 6.4e-05 23.1 0.8 9.5 7 3 2 9 9 9 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_177725.4_2 - 8.1e-08 32.1 0.4 5.6e-05 23.0 0.8 3.0 1 1 1 3 3 3 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_177725.4_2 - 1.8e-06 27.4 17.7 0.0004 19.8 1.6 3.4 1 1 2 3 3 3 3 Leucine-rich repeat ABC_trans_CmpB PF06541.9 NM_177013.3_1 - 0.0088 16.2 13.3 0.019 15.1 13.3 1.5 1 0 0 1 1 1 1 Putative ABC-transporter type IV Jacalin PF01419.15 NM_026918.2_2 - 1.9e-06 27.7 0.1 7.5e-06 25.8 0.0 1.9 1 1 1 2 2 2 1 Jacalin-like lectin domain Beta-prism_lec PF16458.3 NM_026918.2_2 - 0.042 13.7 0.4 0.25 11.2 0.1 2.1 1 1 1 2 2 2 0 Beta-prism lectin ECH_1 PF00378.18 NM_016772.1_3 - 4.4e-48 163.6 0.2 7.7e-48 162.9 0.2 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 NM_016772.1_3 - 1.1e-28 100.5 0.2 1.5e-26 93.6 0.0 2.2 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Transglut_i_TM PF14400.4 NM_016772.1_3 - 0.047 13.6 0.2 0.082 12.8 0.2 1.3 1 0 0 1 1 1 0 Inactive transglutaminase fused to 7 transmembrane helices BAR PF03114.16 NM_001083334.1_2 - 3.4e-45 154.4 12.5 4.8e-45 153.9 12.5 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 NM_001083334.1_2 - 3.4e-10 39.5 0.1 7.9e-10 38.3 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001083334.1_2 - 1.4e-06 27.7 0.0 3.7e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001083334.1_2 - 2.4e-06 26.9 0.1 5.3e-06 25.8 0.1 1.6 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.3 NM_001083334.1_2 - 0.00012 21.7 12.4 0.00015 21.4 8.7 2.1 1 1 1 2 2 2 1 BAR domain of APPL family Jnk-SapK_ap_N PF09744.7 NM_001083334.1_2 - 0.017 15.2 2.8 0.017 15.2 2.8 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 OmpH PF03938.12 NM_001083334.1_2 - 0.044 13.7 13.4 0.034 14.0 1.4 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3104 PF11302.6 NM_001083334.1_2 - 0.14 11.8 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) Laminin_II PF06009.10 NM_001083334.1_2 - 0.83 9.5 6.5 0.91 9.4 0.6 2.3 2 0 0 2 2 2 0 Laminin Domain II Baculo_PEP_C PF04513.10 NM_001083334.1_2 - 1.5 8.7 4.3 6.3 6.7 0.3 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus BLOC1_2 PF10046.7 NM_001083334.1_2 - 4.1 7.6 13.2 0.47 10.7 3.3 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.10 NM_001083334.1_2 - 5.7 6.8 9.0 1.4 8.8 0.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) THP2 PF09432.8 NM_001083334.1_2 - 5.9 6.8 7.0 0.29 11.1 0.7 1.9 2 0 0 2 2 2 0 Tho complex subunit THP2 Filament PF00038.19 NM_025487.3_3 - 4.5e-22 78.9 4.0 5.6e-22 78.6 4.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein Ocular_alb PF02101.13 NM_010951.3_3 - 1.7e-222 738.4 7.4 2e-222 738.2 7.4 1.0 1 0 0 1 1 1 1 Ocular albinism type 1 protein 7tm_2 PF00002.22 NM_010951.3_3 - 1.1e-06 28.0 9.6 1.7e-06 27.4 9.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) SelK_SelG PF10961.6 NM_019979.2_1 - 1.1e-27 96.4 0.4 1.1e-27 96.4 0.4 2.1 2 0 0 2 2 2 1 Selenoprotein SelK_SelG Collagen PF01391.16 NM_001317388.1_1 - 1.6e-160 520.8 637.9 1.4e-08 34.2 30.8 22.5 3 2 14 17 17 17 12 Collagen triple helix repeat (20 copies) COLFI PF01410.16 NM_001317388.1_1 - 6.5e-84 280.7 0.0 8.2e-84 280.4 0.0 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Laminin_G_2 PF02210.22 NM_001317388.1_1 - 2.9e-05 24.5 0.0 0.00014 22.3 0.0 1.9 2 0 0 2 2 2 1 Laminin G domain Laminin_G_3 PF13385.4 NM_001317388.1_1 - 0.00039 20.5 0.0 0.00073 19.6 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.21 NM_001317388.1_1 - 0.027 14.6 0.0 0.052 13.6 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain RRM_1 PF00076.20 NM_010880.3_2 - 1.1e-56 188.4 11.8 9e-17 60.5 0.2 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOA36 PF06524.10 NM_010880.3_2 - 0.0036 16.6 3.1 0.0036 16.6 3.1 4.0 3 1 1 4 4 4 1 NOA36 protein Limkain-b1 PF11608.6 NM_010880.3_2 - 0.19 11.7 0.5 8.1 6.5 0.0 2.9 3 0 0 3 3 3 0 Limkain b1 UPF0560 PF10577.7 NM_001081161.1_1 - 0 1258.7 1.0 0 1258.5 1.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0560 NAD-GH PF10712.7 NM_001081161.1_1 - 0.26 9.6 0.0 0.39 9.0 0.0 1.1 1 0 0 1 1 1 0 NAD-specific glutamate dehydrogenase FAM176 PF14851.4 NM_001081161.1_1 - 0.52 9.8 3.4 24 4.5 3.6 2.4 2 0 0 2 2 2 0 FAM176 family EF-hand_1 PF00036.30 NM_016754.5_1 - 6.2e-09 34.7 3.5 2.2e-05 23.6 0.9 4.3 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.4 NM_016754.5_1 - 5e-08 33.2 0.1 0.00085 19.6 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_016754.5_1 - 9.7e-08 31.2 1.8 2.9e-05 23.5 0.4 3.3 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.4 NM_016754.5_1 - 5.8e-05 22.7 2.3 0.0053 16.4 0.4 3.4 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_016754.5_1 - 0.00035 19.8 1.1 0.00035 19.8 1.1 2.1 2 0 0 2 2 2 1 EF hand 7tm_1 PF00001.19 NM_008312.4_2 - 2.1e-65 220.5 9.2 4e-65 219.6 9.2 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_008312.4_2 - 2.2e-14 53.3 10.7 4.3e-14 52.4 10.7 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_008312.4_2 - 2e-05 24.3 10.2 2e-05 24.3 10.2 2.1 2 0 0 2 2 2 1 Olfactory receptor Nckap1 PF09735.7 NM_016965.3_2 - 0 1732.4 29.0 0 1732.2 29.0 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein LRR_8 PF13855.4 NM_172874.3_2 - 1.3e-74 245.7 49.6 1.7e-16 59.6 4.2 9.2 7 3 1 9 9 9 9 Leucine rich repeat LRR_4 PF12799.5 NM_172874.3_2 - 3.3e-43 144.7 46.9 4.7e-06 26.7 1.2 11.8 5 2 10 15 15 15 15 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_172874.3_2 - 6.8e-20 68.3 42.2 0.81 10.3 0.2 15.8 14 2 2 16 16 16 6 Leucine Rich Repeat LRR_9 PF14580.4 NM_172874.3_2 - 2.2e-12 46.7 17.2 0.026 13.9 0.7 6.5 1 1 6 7 7 7 6 Leucine-rich repeat LRR_5 PF13306.4 NM_172874.3_2 - 5.1e-12 45.7 0.0 0.08 12.8 0.0 4.7 3 2 0 4 4 4 4 Leucine rich repeats (6 copies) LRR_6 PF13516.4 NM_172874.3_2 - 2.5e-09 36.3 35.5 1.3 9.1 0.3 14.0 15 0 0 15 15 15 5 Leucine Rich repeat FNIP PF05725.10 NM_172874.3_2 - 0.00025 21.0 8.7 8.5 6.5 0.1 6.3 4 2 1 5 5 5 2 FNIP Repeat LRRNT PF01462.16 NM_172874.3_2 - 0.0019 17.7 2.0 0.0019 17.7 2.0 4.7 6 0 0 6 6 6 1 Leucine rich repeat N-terminal domain 7tm_1 PF00001.19 NM_001317124.1_1 - 3.3e-67 226.4 0.4 4.7e-67 225.9 0.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001317124.1_1 - 8.6e-07 28.4 12.3 0.0001 21.6 4.4 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_001317124.1_1 - 3.4e-05 23.6 12.8 5.5e-05 22.9 6.6 2.8 2 1 0 2 2 2 1 Olfactory receptor Ion_trans PF00520.29 NM_009783.3_3 - 5.7e-253 834.5 70.4 8.8e-79 264.1 10.8 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.10 NM_009783.3_3 - 1.8e-14 53.1 80.4 4e-09 35.5 1.9 9.5 6 3 3 9 9 9 6 Polycystin cation channel Ctr PF04145.13 NM_009783.3_3 - 0.42 11.1 2.6 4.8 7.7 0.5 3.7 3 1 0 3 3 3 0 Ctr copper transporter family NINJA_B PF16136.3 NM_009783.3_3 - 2.1 8.6 17.2 0.021 15.1 4.3 2.7 2 0 0 2 2 2 0 Putative nuclear localisation signal Neur_chan_memb PF02932.14 NM_009783.3_3 - 3.3 7.6 6.2 0.38 10.6 0.1 2.5 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region Fibrinogen_C PF00147.16 NM_001317105.1_2 - 1.1e-94 316.2 9.6 1.5e-94 315.8 9.6 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fib_alpha PF08702.8 NM_001317105.1_2 - 1.3e-48 164.6 4.9 2.2e-48 164.0 4.9 1.3 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Spc29 PF17082.3 NM_001317105.1_2 - 0.0045 16.7 0.7 0.019 14.7 0.7 1.9 2 0 0 2 2 2 1 Spindle Pole Component 29 TMF_DNA_bd PF12329.6 NM_001317105.1_2 - 0.97 9.3 4.3 1.9 8.4 4.3 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Lipocalin_7 PF14651.4 NM_008375.2_1 - 4.5e-80 265.7 2.2 5.2e-80 265.5 2.2 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Ras PF00071.20 NM_025846.2_3 - 3.6e-57 192.4 0.2 5e-57 191.9 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_025846.2_3 - 1.5e-17 63.8 0.0 2.6e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_025846.2_3 - 5.8e-08 32.3 0.0 8.3e-08 31.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 NM_025846.2_3 - 6.4e-05 22.4 0.0 8.8e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 NM_025846.2_3 - 0.0046 16.9 0.0 0.0069 16.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_025846.2_3 - 0.024 14.4 0.1 3 7.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF2075 PF09848.7 NM_025846.2_3 - 1.4 8.0 3.5 5.1 6.1 1.3 2.0 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Fasciclin PF02469.20 NM_015784.3_1 - 3.3e-106 350.5 0.0 5.5e-28 97.6 0.0 4.3 4 0 0 4 4 4 4 Fasciclin domain DUF211 PF02680.12 NM_015784.3_1 - 1.3 9.1 10.9 1.7 8.7 0.8 3.7 4 0 0 4 4 4 0 Uncharacterized ArCR, COG1888 F420_oxidored PF03807.15 NM_054098.3_1 - 2.7e-13 50.2 0.0 4.4e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.17 NM_054098.3_1 - 4.4e-11 42.9 8.3 4.4e-11 42.9 8.3 2.2 1 1 1 2 2 2 1 Ferric reductase like transmembrane component 2-Hacid_dh_C PF02826.17 NM_054098.3_1 - 0.0016 17.7 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.13 NM_054098.3_1 - 0.0017 18.4 0.0 0.0026 17.8 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.10 NM_054098.3_1 - 0.0047 16.4 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Peptidase_C2 PF00648.19 NM_009796.2_3 - 4.9e-49 166.8 1.0 2.1e-47 161.5 0.0 2.2 2 0 0 2 2 2 1 Calpain family cysteine protease MIT PF04212.16 NM_009796.2_3 - 1.7e-24 85.5 14.0 3.1e-14 52.6 2.8 2.3 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain Calpain_III PF01067.20 NM_009796.2_3 - 3.8e-10 40.1 2.0 2.6e-06 27.6 0.6 3.7 3 1 0 3 3 3 2 Calpain large subunit, domain III TPR_2 PF07719.15 NM_009796.2_3 - 0.00063 19.5 3.0 0.57 10.3 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_009796.2_3 - 0.0051 16.5 3.3 2.4 8.0 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_009796.2_3 - 0.19 11.9 0.9 29 5.1 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.4 NM_009796.2_3 - 0.32 11.0 2.1 5.2 7.2 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.4 NM_009796.2_3 - 0.34 10.5 1.5 1.4 8.5 0.1 2.3 2 0 0 2 2 2 0 TPR repeat TPR_12 PF13424.4 NM_009796.2_3 - 0.38 10.9 5.2 0.87 9.8 0.6 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Rootletin PF15035.4 NM_009796.2_3 - 0.45 10.4 3.5 0.83 9.6 3.5 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Trypsin PF00089.24 NM_009355.2_1 - 4.6e-51 173.6 0.0 5.8e-51 173.3 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_009355.2_1 - 9.3e-11 42.0 0.2 1.5e-10 41.3 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) CCM2_C PF16545.3 NM_145536.3_1 - 1.5e-47 160.1 0.0 3.1e-47 159.1 0.0 1.5 2 0 0 2 2 2 1 Cerebral cavernous malformation protein, harmonin-homology DENN PF02141.19 NM_029811.2_2 - 8.3e-58 195.3 0.5 8.3e-58 195.3 0.5 1.8 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.16 NM_029811.2_2 - 2.1e-17 63.6 0.1 5.1e-17 62.3 0.1 1.7 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 NM_029811.2_2 - 1.4e-12 47.3 4.7 2.6e-12 46.4 3.2 2.4 2 0 0 2 2 2 1 dDENN domain SMRP1 PF15181.4 NM_029811.2_2 - 0.093 12.2 0.3 0.28 10.6 0.1 1.8 2 0 0 2 2 2 0 Spermatid-specific manchette-related protein 1 RRM_1 PF00076.20 NM_001293057.1_1 - 1.7e-26 91.7 0.2 3.5e-13 49.1 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001293057.1_1 - 3e-12 46.4 0.1 2.1e-05 24.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 NM_001293057.1_1 - 3.5e-06 26.8 0.0 0.0019 18.0 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif DUF3524 PF12038.6 NM_172662.3_2 - 1e-70 236.8 0.1 1.4e-70 236.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3524) Glycos_transf_1 PF00534.18 NM_172662.3_2 - 2.2e-08 33.7 0.0 4.6e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.4 NM_172662.3_2 - 0.17 12.2 0.0 0.73 10.1 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferases group 1 DUF3915 PF13054.4 NM_025287.2_2 - 9.3 6.1 9.9 16 5.3 9.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) BTB PF00651.29 NM_025287.2_3 - 8e-33 112.8 1.3 1.9e-32 111.7 0.3 2.0 1 1 1 2 2 2 1 BTB/POZ domain MATH PF00917.24 NM_025287.2_3 - 4.5e-06 26.6 0.0 1.2e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 MATH domain BACK PF07707.13 NM_025287.2_3 - 0.016 15.2 0.1 0.37 10.8 0.0 2.7 3 0 0 3 3 3 0 BTB And C-terminal Kelch DUF3915 PF13054.4 NM_025287.2_3 - 0.92 9.4 7.1 2.4 8.0 7.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) LRR_8 PF13855.4 NM_177708.5_2 - 5.4e-44 147.6 40.9 2e-11 43.3 1.3 5.1 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 NM_177708.5_2 - 4.6e-15 55.3 17.7 0.0011 19.1 0.0 5.9 3 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_177708.5_2 - 3.5e-08 33.3 0.0 0.0002 21.2 0.0 2.4 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_177708.5_2 - 3.4e-06 26.6 0.3 0.0032 16.9 0.3 2.7 2 1 0 2 2 2 2 Leucine-rich repeat UPF0114 PF03350.14 NM_177708.5_2 - 0.17 11.9 0.0 0.32 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein family, UPF0114 LRR_1 PF00560.31 NM_177708.5_2 - 0.63 10.6 10.2 46 4.9 0.0 6.3 6 0 0 6 6 6 0 Leucine Rich Repeat LRRNT PF01462.16 NM_177708.5_2 - 1.5 8.5 10.4 0.017 14.6 1.4 2.6 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain SHIPPO-rpt PF07004.10 NM_001200028.1_3 - 7.2e-05 23.4 6.2 0.0061 17.3 1.0 3.8 3 1 0 3 3 3 2 Sperm-tail PG-rich repeat DnaJ PF00226.29 NM_001037941.3_3 - 4.4e-28 97.0 4.5 8.1e-28 96.2 4.5 1.4 1 0 0 1 1 1 1 DnaJ domain PepSY PF03413.17 NM_001037941.3_3 - 0.48 10.9 3.2 5.7 7.5 0.1 2.6 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain VHS PF00790.17 NM_011484.2_3 - 1.4e-45 154.4 1.0 3.2e-45 153.3 0.0 2.0 2 0 0 2 2 2 1 VHS domain SH3_1 PF00018.26 NM_011484.2_3 - 3.5e-16 58.4 0.1 6e-16 57.7 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_011484.2_3 - 2.1e-13 49.6 0.0 3.7e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_011484.2_3 - 1.2e-12 47.4 0.1 2.1e-12 46.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain UIM PF02809.18 NM_011484.2_3 - 0.00013 21.5 1.8 0.0004 20.0 1.8 1.9 1 0 0 1 1 1 1 Ubiquitin interaction motif GAT PF03127.12 NM_011484.2_3 - 0.015 15.4 3.6 0.031 14.5 3.6 1.5 1 0 0 1 1 1 0 GAT domain Pro_isomerase PF00160.19 NM_011149.2_2 - 3e-49 167.2 0.4 3.8e-49 166.9 0.4 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_M41 PF01434.16 NM_013771.5_3 - 2.1e-73 246.4 1.8 3.2e-73 245.8 1.8 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.27 NM_013771.5_3 - 3.3e-41 140.7 0.0 6.8e-41 139.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 NM_013771.5_3 - 0.00024 21.4 0.0 0.0035 17.6 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.11 NM_013771.5_3 - 0.00059 18.8 0.0 0.001 18.0 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.10 NM_013771.5_3 - 0.0011 18.1 0.0 0.002 17.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 NM_013771.5_3 - 0.0017 18.3 0.0 0.0042 16.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 NM_013771.5_3 - 0.0031 17.7 0.0 0.041 14.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.15 NM_013771.5_3 - 0.015 14.9 0.0 0.038 13.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.19 NM_013771.5_3 - 0.04 13.2 0.3 0.081 12.2 0.3 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.11 NM_013771.5_3 - 0.044 12.8 0.0 0.087 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.4 NM_013771.5_3 - 0.05 13.6 0.0 0.095 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.12 NM_013771.5_3 - 0.054 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.4 NM_013771.5_3 - 0.16 12.4 0.0 0.37 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain FumaraseC_C PF10415.7 NM_013771.5_3 - 0.18 12.1 3.2 1.3 9.4 1.5 3.0 3 0 0 3 3 2 0 Fumarase C C-terminus zf-C2H2 PF00096.24 NM_016686.4_3 - 1.9e-14 53.0 56.4 0.0035 17.6 6.5 7.7 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_016686.4_3 - 1.6e-10 40.8 59.6 2e-05 24.7 2.7 9.3 9 0 0 9 9 9 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_016686.4_3 - 2.6e-08 33.9 77.4 0.0011 19.5 1.0 9.1 10 0 0 10 10 10 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_016686.4_3 - 0.00019 21.2 46.2 0.029 14.2 0.2 7.7 7 0 0 7 7 7 4 C2H2-type zinc finger Spt20 PF12090.6 NM_016686.4_3 - 0.099 12.1 12.7 0.2 11.1 12.7 1.4 1 0 0 1 1 1 0 Spt20 family EOS1 PF12326.6 NM_016686.4_3 - 0.72 9.6 3.7 1.4 8.7 3.7 1.4 1 0 0 1 1 1 0 N-glycosylation protein zf-Di19 PF05605.10 NM_016686.4_3 - 2.2 8.5 34.4 1.8 8.7 3.0 4.9 2 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding TFIIA PF03153.11 NM_016686.4_3 - 5 6.9 14.7 0.089 12.6 6.7 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.30 NM_175539.3_1 - 2.2e-05 25.0 0.2 0.044 14.5 0.5 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat DUF3915 PF13054.4 NM_175539.3_2 - 4.9 7.0 10.8 9.6 6.1 10.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 NM_175539.3_3 - 0.26 11.2 5.6 0.57 10.0 5.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF4505 PF14956.4 NM_176828.4_2 - 3.7e-62 209.1 0.0 5e-62 208.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4505) DUF4505 PF14956.4 NM_176828.4_3 - 4.4e-10 39.4 0.1 6.1e-10 39.0 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4505) ELO PF01151.16 NM_001039176.2_1 - 1.8e-63 214.3 21.3 2.4e-63 213.8 21.3 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family PAF-AH_p_II PF03403.11 NM_001285875.1_1 - 1.2e-23 83.1 0.0 1.6e-23 82.7 0.0 1.1 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II PAF-AH_p_II PF03403.11 NM_001285875.1_3 - 1.7e-107 359.1 0.0 2.3e-107 358.7 0.0 1.1 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Peptidase_S9 PF00326.19 NM_001285875.1_3 - 9.1e-06 25.2 0.1 2.4e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.16 NM_001285875.1_3 - 0.0041 16.6 0.0 0.007 15.8 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Esterase PF00756.18 NM_001285875.1_3 - 0.02 14.4 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Lipase_3 PF01764.23 NM_001285875.1_3 - 0.023 14.5 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Hydrolase_4 PF12146.6 NM_001285875.1_3 - 0.031 13.4 0.1 0.26 10.4 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.14 NM_001285875.1_3 - 0.04 13.6 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.11 NM_001285875.1_3 - 0.059 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.5 NM_001285875.1_3 - 0.063 12.0 0.0 0.16 10.7 0.0 1.6 1 1 0 1 1 1 0 Chlorophyllase enzyme Chlorophyllase PF07224.9 NM_001285875.1_3 - 0.16 10.8 0.1 0.93 8.3 0.0 1.9 2 0 0 2 2 2 0 Chlorophyllase Abhydrolase_5 PF12695.5 NM_001285875.1_3 - 0.21 11.2 0.0 0.47 10.0 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family Sec23_trunk PF04811.13 NM_001281816.1_1 - 3.4e-80 269.0 0.0 4.7e-80 268.5 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.10 NM_001281816.1_1 - 5.9e-31 106.9 0.0 1.4e-30 105.8 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.13 NM_001281816.1_1 - 7.9e-26 89.7 0.2 2.7e-25 88.0 0.1 2.0 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Gelsolin PF00626.20 NM_001281816.1_1 - 7.5e-17 60.9 0.0 2e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat APP_E2 PF12925.5 NM_001281816.1_1 - 0.089 12.4 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein BRO1 PF03097.16 NM_008164.2_2 - 7.2e-83 278.4 0.0 9.8e-83 278.0 0.0 1.1 1 0 0 1 1 1 1 BRO1-like domain HR1 PF02185.14 NM_008164.2_2 - 6.1e-17 61.4 0.8 6.1e-17 61.4 0.8 2.0 2 0 0 2 2 2 1 Hr1 repeat PDZ PF00595.22 NM_008164.2_2 - 6.3e-14 52.0 0.0 1.3e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_008164.2_2 - 4.3e-05 23.6 0.0 8.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PX PF00787.22 NM_008876.3_3 - 1.3e-27 95.9 0.1 2.8e-27 94.8 0.1 1.6 1 0 0 1 1 1 1 PX domain PLDc PF00614.20 NM_008876.3_3 - 1.7e-14 53.1 0.3 7.6e-06 25.8 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.4 NM_008876.3_3 - 2.2e-14 53.4 0.0 6.6e-09 35.6 0.0 2.8 2 1 0 2 2 2 2 PLD-like domain PH PF00169.27 NM_008876.3_3 - 9.1e-05 22.8 0.1 0.00025 21.4 0.1 1.8 1 1 0 1 1 1 1 PH domain PH_2 PF08458.8 NM_008876.3_3 - 0.15 12.3 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region IP_trans PF02121.16 NM_001301644.1_3 - 1.3e-101 339.2 1.2 1.9e-101 338.7 1.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Alpha_kinase PF02816.16 NM_007908.4_2 - 9.7e-54 182.3 0.0 1.6e-53 181.6 0.0 1.3 1 0 0 1 1 1 1 Alpha-kinase family Sel1 PF08238.10 NM_007908.4_2 - 1e-06 29.1 5.0 0.19 12.3 0.0 5.2 5 0 0 5 5 5 3 Sel1 repeat Ifi-6-16 PF06140.11 NM_026790.2_2 - 2.7e-26 91.2 27.0 2.7e-26 91.2 27.0 3.1 4 0 0 4 4 4 2 Interferon-induced 6-16 family CUB PF00431.18 NM_172873.3_2 - 1.1e-87 289.5 0.0 2.1e-30 105.1 0.0 3.1 3 0 0 3 3 3 3 CUB domain CUB_2 PF02408.18 NM_172873.3_2 - 0.00027 20.5 0.1 0.24 11.0 0.0 3.0 3 0 0 3 3 3 2 CUB-like domain ASXH PF13919.4 NM_001039939.1_1 - 7.8e-36 122.9 0.3 1.5e-35 121.9 0.3 1.5 1 0 0 1 1 1 1 Asx homology domain PHD_3 PF13922.4 NM_001039939.1_1 - 2.1e-20 72.7 9.3 6.5e-20 71.2 9.3 1.9 1 0 0 1 1 1 1 PHD domain of transcriptional enhancer, Asx HARE-HTH PF05066.11 NM_001039939.1_1 - 6.7e-18 64.7 0.0 4.7e-17 62.0 0.0 2.2 2 0 0 2 2 2 1 HB1, ASXL, restriction endonuclease HTH domain PHD PF00628.27 NM_001039939.1_1 - 6 6.7 9.9 18 5.2 9.9 1.8 1 0 0 1 1 1 0 PHD-finger AGTRAP PF06396.9 NM_001301281.1_3 - 6.4e-65 217.3 0.0 9.1e-65 216.8 0.0 1.2 1 0 0 1 1 1 1 Angiotensin II, type I receptor-associated protein (AGTRAP) Cyclin_N PF00134.21 NM_001081635.1_1 - 4.6e-34 116.8 0.9 6.3e-34 116.4 0.9 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 NM_001081635.1_1 - 6.8e-17 61.5 0.1 1.8e-16 60.2 0.0 1.7 2 0 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.8 NM_001081635.1_1 - 0.017 15.4 0.3 0.03 14.6 0.3 1.4 1 0 0 1 1 1 0 K cyclin, C terminal LRR_6 PF13516.4 NM_178249.2_1 - 0.041 13.8 1.7 92 3.4 0.0 4.8 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.31 NM_178249.2_1 - 0.072 13.5 8.0 49 4.9 0.1 5.8 4 1 0 4 4 4 0 Leucine Rich Repeat Ras PF00071.20 NM_008996.3_2 - 4.7e-66 221.2 1.1 6.3e-66 220.8 1.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_008996.3_2 - 4.3e-36 123.7 0.1 6.6e-36 123.0 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_008996.3_2 - 2e-16 59.8 0.1 3e-16 59.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 NM_008996.3_2 - 5.2e-05 23.1 0.6 0.14 11.9 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 NM_008996.3_2 - 0.00012 21.4 0.1 0.00018 20.8 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 NM_008996.3_2 - 0.00017 21.1 0.0 0.00028 20.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 NM_008996.3_2 - 0.00024 20.4 0.1 0.0004 19.7 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 NM_008996.3_2 - 0.00027 20.9 0.0 0.00047 20.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA PF00004.27 NM_008996.3_2 - 0.091 13.1 0.0 1.9 8.8 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 NM_008996.3_2 - 0.21 11.8 0.0 0.31 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Elf-1_N PF12310.6 NM_001291059.1_1 - 3.1e-34 117.7 2.6 6.4e-34 116.7 2.6 1.6 1 0 0 1 1 1 1 Transcription factor protein N terminal Ets PF00178.20 NM_001291059.1_1 - 6.2e-34 116.2 1.2 1.1e-33 115.4 1.2 1.4 1 0 0 1 1 1 1 Ets-domain R3H PF01424.20 NM_001177617.1_1 - 1.1e-12 47.6 0.5 4.8e-12 45.6 0.1 2.2 2 0 0 2 2 2 1 R3H domain Sortilin-Vps10 PF15902.3 NM_001252501.1_2 - 1.3e-105 353.6 0.0 1.7e-105 353.3 0.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.3 NM_001252501.1_2 - 1.1e-36 126.6 7.8 1.8e-36 125.9 7.8 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.18 NM_001252501.1_2 - 8.3e-10 38.2 3.6 4.3e-07 29.5 0.1 2.6 2 0 0 2 2 2 2 PKD domain BNR_6 PF15899.3 NM_001252501.1_2 - 0.021 14.7 0.9 1.2 9.3 0.0 3.6 3 0 0 3 3 3 0 BNR-Asp box repeat BNR PF02012.18 NM_001252501.1_2 - 0.11 12.4 13.7 4.6 7.5 0.5 5.8 5 0 0 5 5 5 0 BNR/Asp-box repeat V1R PF03402.12 NM_001166841.1_1 - 1e-15 57.9 12.3 1.4e-15 57.5 12.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001166841.1_1 - 1.2e-13 50.7 13.3 1.8e-13 50.2 13.3 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001166841.1_1 - 1.1e-08 34.5 11.2 1.6e-08 34.0 11.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1700 PF08006.9 NM_001166841.1_1 - 0.046 13.1 0.6 0.046 13.1 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) PRP8_domainIV PF12134.6 NM_001166841.1_1 - 0.16 11.5 0.8 0.7 9.4 0.0 2.2 2 1 1 3 3 3 0 PRP8 domain IV core NTP_transf_2 PF01909.21 NM_001164499.1_3 - 5e-15 55.4 0.1 9.2e-15 54.6 0.1 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.17 NM_001164499.1_3 - 2.6e-14 53.0 0.0 5.4e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase HSR PF03172.11 NM_177055.3_2 - 4e-37 126.2 0.5 7.1e-37 125.4 0.5 1.4 1 0 0 1 1 1 1 HSR domain TB2_DP1_HVA22 PF03134.17 NM_001204914.1_3 - 1.7e-27 95.0 10.0 2.7e-27 94.3 10.0 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2306 PF10067.7 NM_001204914.1_3 - 0.024 14.7 0.5 0.038 14.1 0.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2306) Integrin_alpha2 PF08441.10 NM_001113514.1_1 - 3.2e-67 227.3 0.1 4.9e-67 226.7 0.1 1.2 1 0 0 1 1 1 1 Integrin alpha Integrin_alpha PF00357.18 NM_001113514.1_1 - 0.0016 18.1 0.2 0.0046 16.7 0.2 1.9 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region I-set PF07679.14 NM_008988.2_2 - 6.5e-62 205.5 0.0 5.5e-21 74.3 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_008988.2_2 - 6.3e-59 196.4 0.0 3.1e-16 59.6 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 NM_008988.2_2 - 2.8e-37 126.6 0.0 1.4e-09 37.9 0.0 4.9 4 1 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 NM_008988.2_2 - 1.1e-33 115.3 0.0 1e-07 32.0 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain fn3 PF00041.19 NM_008988.2_2 - 2.7e-24 85.2 0.4 4.7e-13 49.2 0.1 2.7 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.15 NM_008988.2_2 - 8.7e-19 67.6 3.2 0.0015 18.6 0.0 8.0 4 4 1 6 6 6 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_008988.2_2 - 1e-12 47.8 0.5 0.00058 19.8 0.0 4.6 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_008988.2_2 - 3.6e-07 30.4 0.1 0.024 15.0 0.0 3.8 4 0 0 4 4 4 2 Immunoglobulin C1-set domain Pur_ac_phosph_N PF16656.3 NM_008988.2_2 - 0.00019 21.8 0.2 0.0053 17.2 0.0 2.5 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain SPAR_C PF11881.6 NM_001081337.1_1 - 5.4e-72 242.4 0.1 1.3e-71 241.2 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of SPAR protein Rap_GAP PF02145.13 NM_001081337.1_1 - 1.3e-65 220.3 0.0 2.2e-65 219.6 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP PDZ PF00595.22 NM_001081337.1_1 - 2.9e-05 24.2 0.0 5.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) IncA PF04156.12 NM_001081337.1_1 - 0.0068 16.1 1.8 0.012 15.2 1.8 1.3 1 0 0 1 1 1 1 IncA protein CAGE1 PF15066.4 NM_001081337.1_1 - 0.48 8.9 2.4 0.79 8.2 2.4 1.2 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family bZIP_2 PF07716.13 NM_001081337.1_1 - 0.54 10.2 5.0 1.2 9.2 5.0 1.6 1 0 0 1 1 1 0 Basic region leucine zipper CASP_C PF08172.10 NM_001081337.1_1 - 0.78 8.9 4.0 1.7 7.8 4.0 1.5 1 0 0 1 1 1 0 CASP C terminal DUF2968 PF11180.6 NM_001081337.1_1 - 1.1 8.8 7.7 2.5 7.6 7.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DivIC PF04977.13 NM_001081337.1_1 - 4.1 7.1 4.6 8.1 6.2 4.6 1.4 1 0 0 1 1 1 0 Septum formation initiator Fer4_10 PF13237.4 NM_001081337.1_2 - 0.52 10.3 12.8 0.53 10.3 0.9 3.7 3 0 0 3 3 3 0 4Fe-4S dicluster domain T-box PF00907.20 NM_001285472.1_1 - 5.9e-80 267.7 0.1 7.4e-80 267.4 0.1 1.1 1 0 0 1 1 1 1 T-box HbrB PF08539.9 NM_175181.5_1 - 2.4e-12 47.0 0.3 6.2e-11 42.4 0.1 2.2 1 1 1 2 2 2 2 HbrB-like DEAD PF00270.27 NM_028041.2_1 - 8.9e-50 168.7 0.0 1.9e-49 167.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_028041.2_1 - 6.4e-21 74.7 0.0 7e-20 71.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.10 NM_028041.2_1 - 1.5e-18 66.7 9.0 4.2e-18 65.2 9.0 1.9 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.13 NM_028041.2_1 - 1.6e-06 28.1 0.0 3.6e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 NM_028041.2_1 - 0.00058 19.0 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF572 PF04502.11 NM_028381.3_1 - 9.6e-111 370.4 12.7 1.1e-110 370.1 12.7 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) 7tm_4 PF13853.4 NM_146530.2_1 - 1.3e-50 172.6 21.8 1.6e-50 172.3 21.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146530.2_1 - 7.9e-19 67.8 26.2 1.8e-18 66.6 26.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146530.2_1 - 0.0003 20.1 26.9 0.0016 17.8 26.9 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx bZIP_Maf PF03131.15 NM_001304831.1_2 - 2.7e-32 111.0 10.2 4.1e-32 110.4 10.2 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.19 NM_001304831.1_2 - 0.0028 17.6 14.4 0.0089 16.0 14.4 1.7 1 1 0 1 1 1 1 bZIP transcription factor DivIC PF04977.13 NM_001304831.1_2 - 0.075 12.7 4.6 0.041 13.5 1.9 1.8 1 1 0 1 1 1 0 Septum formation initiator bZIP_2 PF07716.13 NM_001304831.1_2 - 0.084 12.8 12.3 0.19 11.7 12.3 1.6 1 0 0 1 1 1 0 Basic region leucine zipper DUF1192 PF06698.9 NM_001304831.1_2 - 4.5 7.3 7.2 0.45 10.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) 7tm_1 PF00001.19 NM_021340.4_1 - 7e-23 81.1 3.8 2e-22 79.6 3.8 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2160 PF09928.7 NM_021340.4_1 - 0.028 14.6 1.0 0.59 10.4 0.2 2.4 1 1 1 2 2 2 0 Predicted small integral membrane protein (DUF2160) 4HBT PF03061.20 NM_025416.3_2 - 0.00025 21.2 0.0 0.0004 20.5 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Cupin_8 PF13621.4 NM_001037742.2_1 - 2.8e-41 141.9 0.0 3.9e-41 141.4 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.10 NM_001037742.2_1 - 2.4e-08 33.7 0.0 7.1e-08 32.1 0.0 1.8 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.20 NM_001037742.2_1 - 0.017 15.4 0.0 0.04 14.2 0.0 1.6 1 0 0 1 1 1 0 JmjC domain, hydroxylase CSD PF00313.20 NM_011733.2_1 - 6.1e-26 89.9 0.5 9.3e-26 89.3 0.5 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.9 NM_011733.2_1 - 0.025 14.1 0.0 0.059 12.9 0.0 1.6 1 0 0 1 1 1 0 Ribonuclease B OB domain IF-2B PF01008.15 NM_026423.4_2 - 1.6e-78 263.7 0.0 1.9e-78 263.4 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family zf-H2C2_2 PF13465.4 NM_080461.2_1 - 5.2e-67 219.4 57.5 2.9e-09 36.8 0.2 10.2 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_080461.2_1 - 5e-45 149.4 57.2 2.4e-06 27.5 2.6 9.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_080461.2_1 - 2.5e-31 105.5 57.6 0.00049 20.6 0.2 9.4 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_080461.2_1 - 4.1e-20 71.4 8.1 0.46 10.7 0.0 9.2 8 1 1 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_080461.2_1 - 2.2e-17 62.4 55.6 0.0011 18.8 0.5 9.9 9 1 0 9 9 9 8 C2H2-type zinc finger zf-Di19 PF05605.10 NM_080461.2_1 - 6.5e-14 51.8 29.9 0.00049 20.2 1.9 6.1 1 1 7 8 8 8 7 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.8 NM_080461.2_1 - 3.4e-08 33.3 37.7 0.0076 16.2 1.0 7.0 4 2 5 9 9 9 5 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_080461.2_1 - 1.2e-06 29.0 11.8 0.5 11.0 0.2 4.5 2 1 0 4 4 4 3 zinc-ribbon family GAGA PF09237.9 NM_080461.2_1 - 2.4e-05 23.9 20.7 0.053 13.2 0.5 6.6 3 2 5 8 8 8 3 GAGA factor HypA PF01155.17 NM_080461.2_1 - 0.00023 21.0 15.3 1.5 8.7 0.1 4.8 1 1 4 5 5 5 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA SprT-like PF10263.7 NM_080461.2_1 - 0.00033 20.4 21.7 0.9 9.2 4.4 4.7 1 1 3 4 4 4 3 SprT-like family FYVE PF01363.19 NM_080461.2_1 - 0.00075 19.4 30.7 0.18 11.8 1.1 5.7 1 1 4 5 5 5 2 FYVE zinc finger PGAMP PF07644.9 NM_080461.2_1 - 0.00099 18.9 4.9 4.6 7.1 0.3 5.0 5 0 0 5 5 4 1 Planctomycete PGAMP zf-C2HC_2 PF13913.4 NM_080461.2_1 - 0.0012 18.5 36.7 1.2 9.0 0.3 8.6 9 0 0 9 9 8 3 zinc-finger of a C2HC-type DZR PF12773.5 NM_080461.2_1 - 0.0026 17.6 34.9 1.6e+04 -16.0 34.9 5.2 1 1 0 1 1 0 0 Double zinc ribbon XPA_N PF01286.16 NM_080461.2_1 - 0.0039 17.1 17.9 29 4.7 0.0 8.4 9 0 0 9 9 9 0 XPA protein N-terminal C1_1 PF00130.20 NM_080461.2_1 - 0.0073 16.0 21.5 1.9 8.3 0.9 6.4 2 2 5 7 7 7 2 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3268 PF11672.6 NM_080461.2_1 - 0.011 15.9 14.2 2.6 8.2 0.4 4.5 3 1 3 6 6 6 0 zinc-finger-containing domain zf-LYAR PF08790.9 NM_080461.2_1 - 0.014 15.2 13.7 3.7 7.4 0.0 6.4 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger IBR PF01485.19 NM_080461.2_1 - 0.046 13.8 25.8 1.2 9.2 4.0 5.2 2 2 2 4 4 4 0 IBR domain, a half RING-finger domain zf-C2H2_9 PF16293.3 NM_080461.2_1 - 0.058 13.1 14.8 52 3.7 0.1 6.9 8 0 0 8 8 7 0 C2H2 type zinc-finger (1 copy) ADK_lid PF05191.12 NM_080461.2_1 - 0.069 13.1 12.2 2.2 8.3 0.7 5.5 2 2 3 5 5 5 0 Adenylate kinase, active site lid FYDLN_acid PF09538.8 NM_080461.2_1 - 0.18 12.3 31.0 22 5.7 0.1 8.9 3 2 7 10 10 9 0 Protein of unknown function (FYDLN_acid) TerY_C PF15616.4 NM_080461.2_1 - 0.2 11.6 18.6 1.3 9.0 1.6 4.3 1 1 3 5 5 5 0 TerY-C metal binding domain zinc_ribbon_9 PF14369.4 NM_080461.2_1 - 0.62 10.2 38.6 2.6 8.2 0.1 8.4 9 0 0 9 9 8 0 zinc-ribbon CpXC PF14353.4 NM_080461.2_1 - 1.1 9.1 23.2 23 4.9 0.1 7.4 4 2 3 7 7 7 0 CpXC protein zf-met PF12874.5 NM_080461.2_1 - 1.6 9.1 0.0 1.6 9.1 0.0 8.2 9 0 0 9 9 8 0 Zinc-finger of C2H2 type Rad50_zn_hook PF04423.12 NM_080461.2_1 - 2 8.2 24.7 2 8.2 0.1 6.6 7 1 1 8 8 7 0 Rad50 zinc hook motif zf-C2H2_2 PF12756.5 NM_080461.2_1 - 2.3 8.5 25.3 6.5 7.0 2.0 7.2 1 1 6 7 7 7 0 C2H2 type zinc-finger (2 copies) zinc-ribbons_6 PF07191.10 NM_080461.2_1 - 2.9 7.8 24.2 12 5.9 0.6 5.2 1 1 1 2 2 1 0 zinc-ribbons zf-AN1 PF01428.14 NM_080461.2_1 - 3.6 7.7 36.7 13 5.9 0.1 9.0 10 0 0 10 10 9 0 AN1-like Zinc finger Endonuclease_7 PF02945.13 NM_080461.2_1 - 5.2 6.9 26.2 0.19 11.5 1.5 4.2 1 1 3 4 4 4 0 Recombination endonuclease VII zf-DNA_Pol PF08996.8 NM_080461.2_1 - 5.4 6.6 11.9 5.6 6.6 0.2 3.5 2 2 2 4 4 4 0 DNA Polymerase alpha zinc finger Band_7 PF01145.23 NM_008027.2_1 - 1.2e-22 80.7 0.1 1.2e-22 80.7 0.1 3.0 2 1 0 2 2 2 1 SPFH domain / Band 7 family Flot PF15975.3 NM_008027.2_1 - 1.8e-08 34.5 6.8 1.8e-08 34.5 6.8 3.9 2 2 1 3 3 3 1 Flotillin V-set PF07686.15 NM_001160713.1_3 - 1.4e-11 44.3 0.0 2.8e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 NM_001160713.1_3 - 0.0029 17.6 0.0 0.008 16.2 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_001160713.1_3 - 0.0031 18.0 0.0 0.0079 16.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Herpes_gE PF02480.14 NM_001160713.1_3 - 0.059 12.0 0.0 0.09 11.4 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E I-set PF07679.14 NM_001160713.1_3 - 0.16 11.9 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain Soyouz_module PF14313.4 NM_001160713.1_3 - 5.9 6.6 5.6 7.2 6.3 0.3 3.0 3 0 0 3 3 3 0 N-terminal region of Paramyxovirinae phosphoprotein (P) Pkinase PF00069.23 NM_001161849.2_2 - 1.6e-69 234.1 0.0 2.1e-69 233.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001161849.2_2 - 2.9e-35 121.7 0.0 4e-35 121.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001161849.2_2 - 1.3e-06 27.8 0.1 2.9e-06 26.7 0.1 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 NM_001161849.2_2 - 5.4e-06 26.9 0.1 1.3e-05 25.6 0.1 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.12 NM_001161849.2_2 - 0.0094 15.2 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 NM_001161849.2_2 - 0.018 14.6 0.1 2 7.9 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 HLH PF00010.24 NM_173789.4_1 - 6.4e-17 61.1 0.3 1.4e-16 60.0 0.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.11 NM_173789.4_1 - 4.5e-08 33.0 0.3 1.4e-07 31.4 0.3 2.0 1 0 0 1 1 1 1 Hairy Orange zf-H2C2_2 PF13465.4 NM_029584.1_3 - 8.7e-44 145.9 72.4 6.7e-09 35.7 1.7 9.5 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.24 NM_029584.1_3 - 9.3e-26 88.7 90.5 0.00022 21.4 0.9 9.4 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_029584.1_3 - 1.3e-15 56.6 84.9 0.0057 17.3 0.9 9.8 9 0 0 9 9 9 8 C2H2-type zinc finger KRAB PF01352.25 NM_029584.1_3 - 3.3e-14 52.2 0.1 7.7e-14 51.0 0.1 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_029584.1_3 - 8.4e-05 22.3 60.7 0.061 13.2 0.6 8.4 8 0 0 8 8 8 5 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_029584.1_3 - 0.0052 16.4 0.5 0.0052 16.4 0.5 7.4 8 1 0 8 8 8 2 C2H2-type zinc-finger domain HypA PF01155.17 NM_029584.1_3 - 0.036 13.9 0.4 0.036 13.9 0.4 4.4 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_jaz PF12171.6 NM_029584.1_3 - 2.1 8.6 44.8 0.61 10.3 0.7 7.4 8 0 0 8 8 8 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_029584.1_3 - 4.4 7.4 43.0 0.25 11.4 2.9 5.6 4 2 1 5 5 5 0 Zinc ribbon domain V1R PF03402.12 NM_053228.1_1 - 1.2e-140 467.5 24.8 1.5e-140 467.2 24.8 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_053228.1_1 - 0.00019 20.5 31.3 0.00046 19.3 31.3 1.9 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_053228.1_1 - 0.57 9.2 24.3 2.7 7.0 24.3 1.9 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) MotB_plug PF13677.4 NM_053228.1_1 - 8.5 5.9 9.1 0.47 10.0 2.0 2.4 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB CLZ PF16526.3 NM_029586.2_1 - 0.11 12.7 0.3 0.11 12.7 0.3 1.8 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels IncA PF04156.12 NM_029586.2_1 - 0.37 10.4 4.5 0.51 10.0 4.5 1.2 1 0 0 1 1 1 0 IncA protein HLH PF00010.24 NM_007855.3_2 - 3.1e-16 58.9 0.6 6.9e-16 57.8 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF773 PF05600.10 NM_007855.3_2 - 0.13 10.8 0.5 0.18 10.4 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF773) BAR PF03114.16 NM_001270537.1_2 - 2.7e-36 125.3 14.6 4.6e-36 124.5 14.6 1.3 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.3 NM_001270537.1_2 - 3.8 7.0 17.3 1.1 8.7 11.7 2.4 1 1 1 2 2 2 0 BAR domain of APPL family 7tm_1 PF00001.19 NM_013503.3_2 - 1.3e-72 244.2 6.7 1.8e-72 243.7 6.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_013503.3_2 - 7.4e-11 41.8 9.4 1.1e-05 24.8 3.6 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_013503.3_2 - 0.00014 21.1 7.2 0.00014 21.1 7.2 3.1 4 0 0 4 4 4 1 Serpentine type 7TM GPCR chemoreceptor Srx La PF05383.15 NM_001284521.1_3 - 6e-17 61.3 0.3 1.2e-16 60.3 0.3 1.5 1 0 0 1 1 1 1 La domain Cullin PF00888.20 NM_028288.5_1 - 2.2e-210 700.2 21.0 2.9e-210 699.8 21.0 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 NM_028288.5_1 - 2.9e-25 87.9 1.6 9.5e-25 86.3 1.6 2.0 1 0 0 1 1 1 1 Cullin protein neddylation domain SecA_SW PF07516.11 NM_028288.5_1 - 0.0006 19.8 1.4 0.0006 19.8 1.4 2.8 3 1 0 3 3 3 1 SecA Wing and Scaffold domain CCDC85 PF10226.7 NM_028288.5_1 - 5.8 6.4 8.4 0.087 12.4 0.2 2.1 2 0 0 2 2 2 0 CCDC85 family TMEM37 PF15108.4 NM_019432.2_1 - 1.5e-96 321.4 10.4 1.8e-96 321.1 10.4 1.0 1 0 0 1 1 1 1 Voltage-dependent calcium channel gamma-like subunit protein family TM140 PF14985.4 NM_019432.2_1 - 0.00024 20.6 8.2 0.00031 20.2 8.2 1.1 1 0 0 1 1 1 1 TM140 protein family DUF1129 PF06570.9 NM_019432.2_1 - 0.83 9.0 2.7 1.3 8.4 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) TNF PF00229.16 NM_013693.3_3 - 1.2e-37 128.6 0.0 1.9e-37 127.9 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family IL1 PF00340.17 NM_008361.4_1 - 3.3e-44 149.3 0.3 5.3e-44 148.6 0.3 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.14 NM_008361.4_1 - 2.1e-34 118.6 0.1 3.5e-34 117.9 0.1 1.4 1 0 0 1 1 1 1 Interleukin-1 propeptide V-set PF07686.15 NM_001037168.1_3 - 2.3e-37 127.3 1.3 6.2e-10 39.1 0.0 5.0 4 1 0 4 4 4 4 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001037168.1_3 - 2.2e-23 82.5 0.5 3.1e-09 37.2 0.1 4.5 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 NM_001037168.1_3 - 1.8e-21 75.9 0.0 3.1e-09 36.7 0.0 4.6 4 1 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001037168.1_3 - 7e-14 51.8 2.7 1.5e-07 31.5 0.3 4.9 4 3 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 NM_001037168.1_3 - 9.2e-14 51.3 3.8 1.5e-07 31.4 0.2 4.4 4 0 0 4 4 4 3 Immunoglobulin domain Receptor_2B4 PF11465.6 NM_001037168.1_3 - 0.0004 20.4 0.1 5.1 7.2 0.0 4.0 4 0 0 4 4 4 2 Natural killer cell receptor 2B4 ANTH PF07651.14 NM_001252520.1_3 - 7.4e-82 274.3 0.8 1e-81 273.8 0.8 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.18 NM_001252520.1_3 - 5.5e-13 48.9 0.1 9.9e-13 48.1 0.1 1.4 1 0 0 1 1 1 1 ENTH domain Herpes_PAP PF03325.11 NM_001252520.1_3 - 9.4 5.1 6.2 9.1 5.2 0.0 2.1 2 0 0 2 2 2 0 Herpesvirus polymerase accessory protein APP_E2 PF12925.5 NM_001198823.1_3 - 1.9e-74 249.3 20.6 3.2e-74 248.6 20.6 1.3 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 NM_001198823.1_3 - 2.2e-44 149.7 0.6 2.2e-44 149.7 0.6 2.1 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding APP_Cu_bd PF12924.5 NM_001198823.1_3 - 1.2e-25 89.9 7.9 2.7e-25 88.7 4.7 2.7 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.7 NM_001198823.1_3 - 9.6e-25 86.8 0.3 9.6e-25 86.8 0.3 2.4 2 0 0 2 2 2 1 beta-amyloid precursor protein C-terminus Beta-APP PF03494.11 NM_001198823.1_3 - 1.1e-24 85.8 2.3 2e-24 85.0 2.3 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) Kunitz_BPTI PF00014.21 NM_001198823.1_3 - 1.6e-19 69.7 6.0 3.4e-19 68.7 6.0 1.6 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Mod_r PF07200.11 NM_001198823.1_3 - 0.38 10.7 11.2 0.052 13.5 5.9 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein PilJ PF13675.4 NM_001198823.1_3 - 1.3 9.0 6.8 0.23 11.4 1.8 2.2 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term p450 PF00067.20 NM_007809.3_2 - 7.4e-139 463.3 0.0 9e-139 463.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FTHFS PF01268.17 NM_001170785.1_1 - 6.1e-261 866.3 0.1 7.3e-261 866.1 0.1 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.17 NM_001170785.1_1 - 2.8e-27 94.9 0.0 1.7e-26 92.3 0.0 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.21 NM_001170785.1_1 - 5.5e-16 58.8 1.1 2e-15 57.0 0.6 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GTP_EFTU PF00009.25 NM_008179.2_3 - 8.7e-46 155.8 0.0 1.8e-45 154.7 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 NM_008179.2_3 - 7.3e-30 103.4 2.9 1.4e-29 102.5 0.1 2.8 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 NM_008179.2_3 - 1.1e-07 31.9 0.0 3e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 PAM2 PF07145.13 NM_008179.2_3 - 1.9e-06 27.1 7.9 1.8e-05 24.0 0.2 3.0 2 1 1 3 3 3 2 Ataxin-2 C-terminal region MMR_HSR1 PF01926.21 NM_008179.2_3 - 0.0031 17.4 0.1 0.011 15.7 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTF2I PF02946.12 NM_001080747.2_3 - 1.6e-186 604.7 12.2 1.4e-31 108.2 0.0 6.3 6 0 0 6 6 6 6 GTF2I-like repeat GBP PF02263.17 NM_172777.3_2 - 1e-114 382.0 0.0 1e-114 382.0 0.0 1.8 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 NM_172777.3_2 - 3.7e-112 374.4 22.1 4.8e-112 374.1 22.1 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain MMR_HSR1 PF01926.21 NM_172777.3_2 - 0.066 13.2 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF106 PF01956.14 NM_172777.3_2 - 4.9 6.7 8.6 6.5 6.3 6.9 2.1 2 0 0 2 2 2 0 Integral membrane protein DUF106 CHORD PF04968.10 NM_013712.2_2 - 3.7e-52 174.8 12.0 2.1e-27 95.5 1.6 3.1 3 0 0 3 3 3 2 CHORD CS PF04969.14 NM_013712.2_2 - 2.6e-12 47.5 0.1 4.2e-12 46.8 0.1 1.4 1 0 0 1 1 1 1 CS domain zf-tcix PF14952.4 NM_013712.2_2 - 1.8 8.1 7.3 8.5 6.0 0.1 2.9 3 0 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding BTK PF00779.17 NM_013712.2_2 - 7.8 6.3 20.0 0.28 10.9 0.8 3.9 5 1 0 5 5 5 0 BTK motif LEM PF03020.13 NM_001311102.1_1 - 2.2e-18 65.4 0.2 3.9e-18 64.6 0.2 1.4 1 0 0 1 1 1 1 LEM domain SpoIIM PF01944.15 NM_001311102.1_1 - 0.069 13.1 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein M 7tm_1 PF00001.19 NM_001304948.1_3 - 1.8e-58 197.8 28.0 1.8e-58 197.8 28.0 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001304948.1_3 - 1.2e-08 34.5 26.6 1.2e-08 34.5 26.6 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001304948.1_3 - 3.2e-05 23.2 27.9 3.2e-05 23.2 27.9 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Hormone_1 PF00103.18 NM_001163530.1_1 - 7e-56 189.2 0.1 8.4e-56 189.0 0.1 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Noelin-1 PF12308.6 NM_001163530.1_1 - 0.054 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Neurogenesis glycoprotein RSN1_7TM PF02714.13 NM_172583.2_3 - 5.4e-56 189.8 28.7 5.4e-56 189.8 28.7 2.3 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.4 NM_172583.2_3 - 1.5e-49 168.5 0.7 2.1e-49 168.0 0.7 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.4 NM_172583.2_3 - 2.1e-17 63.2 4.9 2.1e-17 63.2 4.9 3.9 3 1 0 3 3 3 1 Late exocytosis, associated with Golgi transport Renin_r PF07850.12 NM_172583.2_3 - 7.3 7.1 5.7 12 6.4 0.3 3.1 2 0 0 2 2 2 0 Renin receptor-like protein Biopterin_H PF00351.19 NM_001136084.2_3 - 1.3e-171 570.0 0.0 1.7e-171 569.6 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 NM_001136084.2_3 - 7.6e-06 25.5 0.0 1.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.4 NM_001136084.2_3 - 0.043 14.3 0.2 0.12 12.9 0.1 1.8 2 0 0 2 2 2 0 ACT domain FAM27 PF15832.3 NM_001136084.2_3 - 1.4 9.3 9.8 0.12 12.8 4.6 1.8 2 0 0 2 2 2 0 FAM27 D and E protein family SCAN PF02023.15 NM_001290453.1_1 - 4.1e-35 119.3 0.6 6.6e-35 118.7 0.6 1.3 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 NM_001290453.1_2 - 1.8e-75 246.1 73.3 7.2e-09 35.6 0.2 14.5 14 1 0 14 14 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001290453.1_2 - 3.7e-62 203.3 89.8 1.9e-06 27.9 1.9 14.2 14 0 0 14 14 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001290453.1_2 - 1.6e-37 124.7 87.4 0.0023 18.5 1.8 14.6 14 0 0 14 14 13 13 C2H2-type zinc finger ADK_lid PF05191.12 NM_001290453.1_2 - 3.8e-09 36.3 20.8 0.94 9.4 0.0 8.4 5 2 3 8 8 8 6 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 NM_001290453.1_2 - 6.1e-07 29.3 59.9 0.04 13.9 2.0 9.8 5 3 6 11 11 11 9 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_001290453.1_2 - 1.4e-06 27.9 65.6 0.3 11.0 0.5 13.1 13 0 0 13 13 13 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001290453.1_2 - 0.00014 21.9 22.3 1.8 8.8 0.0 9.3 11 0 0 11 11 10 1 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001290453.1_2 - 0.0071 16.9 33.2 1.7 9.4 2.4 7.0 2 2 7 10 10 10 4 zinc-ribbon family LIM PF00412.20 NM_001290453.1_2 - 0.014 15.5 2.7 0.014 15.5 2.7 8.7 4 2 6 10 10 9 0 LIM domain FYDLN_acid PF09538.8 NM_001290453.1_2 - 0.015 15.9 23.1 20 5.8 0.1 8.6 2 2 6 9 9 9 0 Protein of unknown function (FYDLN_acid) DUF3268 PF11672.6 NM_001290453.1_2 - 0.019 15.2 17.7 5 7.4 0.2 5.6 4 1 0 5 5 5 0 zinc-finger-containing domain MBD PF01429.17 NM_001290453.1_2 - 0.021 14.4 0.4 8.5 6.0 0.0 3.5 3 1 0 3 3 2 0 Methyl-CpG binding domain HypA PF01155.17 NM_001290453.1_2 - 0.023 14.5 36.4 6 6.8 3.2 7.0 1 1 5 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HE PF16278.3 NM_001290453.1_2 - 0.034 14.5 48.5 1.1 9.7 2.2 10.3 2 2 5 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger zf-LYAR PF08790.9 NM_001290453.1_2 - 2 8.2 41.0 11 5.9 0.2 11.2 13 0 0 13 13 13 0 LYAR-type C2HC zinc finger CpXC PF14353.4 NM_001290453.1_2 - 6.7 6.6 35.9 7 6.6 0.1 9.0 3 3 6 10 10 10 0 CpXC protein ING PF12998.5 NM_001302460.1_1 - 4.2e-13 49.6 0.7 4.2e-13 49.6 0.7 1.7 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.27 NM_001302460.1_1 - 1.2e-05 24.9 8.4 1.2e-05 24.9 8.4 2.2 2 0 0 2 2 2 1 PHD-finger DUF4661 PF15576.4 NM_001302460.1_1 - 0.65 9.7 2.3 0.99 9.1 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Dsh_C PF12316.6 NM_001302460.1_1 - 0.69 10.2 7.4 1.1 9.5 7.4 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal CDC45 PF02724.12 NM_001302460.1_1 - 1.1 7.3 7.3 1.5 6.9 7.3 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.11 NM_001302460.1_1 - 1.2 7.7 6.8 0.18 10.4 3.2 1.4 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.10 NM_001302460.1_1 - 6 6.5 9.1 9.4 5.8 9.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Redoxin PF08534.8 NM_012021.2_2 - 2.8e-29 101.6 0.0 3.6e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.19 NM_012021.2_2 - 9.9e-15 54.4 0.0 1.2e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family 2-Hacid_dh_C PF02826.17 NM_001198861.1_2 - 2.5e-55 186.4 0.0 3.5e-55 186.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 NM_001198861.1_2 - 3.1e-28 98.0 0.0 4.1e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 NM_001198861.1_2 - 9.9e-05 22.4 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Cellsynth_D PF03500.11 NM_001198861.1_2 - 0.16 11.7 0.0 0.45 10.3 0.0 1.7 1 0 0 1 1 1 0 Cellulose synthase subunit D DUF3915 PF13054.4 NM_001025577.2_1 - 0.57 10.0 7.2 1.4 8.8 7.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Peptidase_S49_N PF08496.8 NM_001025577.2_1 - 1.5 8.8 5.1 2.5 8.1 5.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal bZIP_Maf PF03131.15 NM_001025577.2_2 - 8.1e-34 115.9 11.9 8.1e-34 115.9 11.9 2.0 2 0 0 2 2 2 1 bZIP Maf transcription factor Maf_N PF08383.9 NM_001025577.2_2 - 9.3e-20 70.0 0.5 1.8e-19 69.1 0.5 1.5 1 0 0 1 1 1 1 Maf N-terminal region ZapB PF06005.10 NM_001025577.2_2 - 0.017 15.4 1.2 0.017 15.4 1.2 2.8 3 0 0 3 3 3 0 Cell division protein ZapB JIP_LZII PF16471.3 NM_001025577.2_2 - 2.9 8.0 7.0 0.29 11.2 1.8 1.9 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II TraT PF05818.10 NM_001025577.2_2 - 6.7 6.2 13.2 0.47 10.0 0.3 2.2 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein zf-H2C2_2 PF13465.4 NM_001190302.2_1 - 7.1e-05 22.9 12.8 0.07 13.5 0.2 4.4 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.4 NM_001190302.2_1 - 0.002 17.9 1.1 0.0053 16.5 1.1 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.4 NM_001190302.2_1 - 0.0091 16.6 2.1 0.057 14.1 0.8 3.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001190302.2_1 - 0.011 16.0 6.5 0.016 15.5 1.3 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001190302.2_2 - 2e-131 422.9 145.9 1e-09 38.3 1.3 20.1 20 0 0 20 20 20 18 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001190302.2_2 - 8e-79 255.8 143.7 2.8e-06 27.3 1.1 18.9 19 0 0 19 19 18 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001190302.2_2 - 2.2e-49 161.6 136.9 0.0001 22.7 0.9 19.6 20 0 0 20 20 18 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001190302.2_2 - 2.6e-42 141.9 125.3 8.7e-05 22.2 2.6 18.5 18 1 0 18 18 18 16 C2H2-type zinc finger KRAB PF01352.25 NM_001190302.2_2 - 2.1e-19 68.8 0.0 3.6e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001190302.2_2 - 2.2e-16 59.5 82.1 0.02 14.9 2.1 11.7 4 4 8 13 13 13 12 Zinc ribbon domain DUF3268 PF11672.6 NM_001190302.2_2 - 1.1e-10 41.7 59.4 0.053 13.7 0.7 9.2 5 3 2 9 9 9 7 zinc-finger-containing domain XPA_N PF01286.16 NM_001190302.2_2 - 4.3e-10 39.3 63.1 3.6 7.6 0.1 16.1 17 0 0 17 17 17 4 XPA protein N-terminal zf-C2H2_jaz PF12171.6 NM_001190302.2_2 - 4.9e-10 39.3 110.3 0.013 15.7 2.0 17.0 17 0 0 17 17 17 7 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001190302.2_2 - 2.3e-07 31.3 75.7 0.13 12.9 3.8 8.9 3 2 6 9 9 9 8 zinc-ribbon family zf-trcl PF13451.4 NM_001190302.2_2 - 0.00057 19.6 74.9 2.1 8.2 3.5 14.4 12 4 0 12 12 12 3 Probable zinc-ribbon domain C1_4 PF07975.10 NM_001190302.2_2 - 0.0012 18.9 82.7 0.39 10.9 0.8 11.7 3 2 9 14 14 13 6 TFIIH C1-like domain GATA PF00320.25 NM_001190302.2_2 - 0.0025 17.3 57.7 8 6.0 0.1 14.0 12 3 3 15 15 15 1 GATA zinc finger IBD PF10416.7 NM_001190302.2_2 - 0.0072 16.2 17.1 47 3.9 0.1 8.6 4 3 2 8 8 8 0 Transcription-initiator DNA-binding domain IBD Csm1 PF12539.6 NM_001190302.2_2 - 0.032 14.7 16.4 5.9 7.5 0.3 8.2 4 3 6 10 10 10 0 Chromosome segregation protein Csm1/Pcs1 zf-C2H2_11 PF16622.3 NM_001190302.2_2 - 0.06 13.0 0.3 0.06 13.0 0.3 15.6 18 0 0 18 18 18 0 zinc-finger C2H2-type CpXC PF14353.4 NM_001190302.2_2 - 0.36 10.7 66.0 15 5.5 0.3 14.1 12 2 2 14 14 14 0 CpXC protein FYVE PF01363.19 NM_001190302.2_2 - 0.65 10.0 85.3 1 9.4 11.9 9.1 1 1 4 5 5 3 0 FYVE zinc finger NCBP3 PF10309.7 NM_001190302.2_3 - 0.088 12.5 6.7 22 4.9 0.0 5.8 5 1 0 5 5 5 0 Nuclear cap-binding protein subunit 3 DUF3791 PF12668.5 NM_001190302.2_3 - 0.26 11.2 5.7 16 5.5 0.0 5.2 6 0 0 6 6 6 0 Protein of unknown function (DUF3791) RVP_2 PF08284.9 NM_001190302.2_3 - 0.75 9.6 5.9 15 5.4 0.0 5.1 4 2 2 7 7 7 0 Retroviral aspartyl protease zf-C2H2 PF00096.24 NM_001190302.2_3 - 1.6 9.2 4.8 9.2 6.8 0.1 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type MIP PF00230.18 NM_175105.3_3 - 2.3e-09 37.2 5.3 5.1e-07 29.5 3.2 2.1 1 1 1 2 2 2 2 Major intrinsic protein UPF0014 PF03649.11 NM_175105.3_3 - 2.7 7.2 8.9 3.1 6.9 1.6 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0014) V1R PF03402.12 NM_134195.2_1 - 5.6e-24 85.0 23.1 5.6e-24 85.0 23.1 1.4 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_134195.2_1 - 4.5e-09 35.7 33.4 6.1e-09 35.3 33.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_134195.2_1 - 2.5e-08 33.4 26.9 3.3e-08 32.9 26.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Abhydrolase_9_N PF15420.4 NM_134195.2_1 - 0.021 14.7 0.8 0.021 14.7 0.8 1.7 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus SecG PF03840.12 NM_134195.2_1 - 5.5 7.0 11.2 0.65 10.0 4.9 2.8 2 0 0 2 2 2 0 Preprotein translocase SecG subunit Ank_2 PF12796.5 NM_028301.4_1 - 7.6e-46 154.5 0.4 1.3e-14 54.4 0.0 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.28 NM_028301.4_1 - 1.2e-26 91.8 0.6 3.9e-05 23.8 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.4 NM_028301.4_1 - 4.1e-26 90.9 0.6 3.4e-08 33.7 0.0 4.9 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_028301.4_1 - 2.4e-25 85.7 0.1 9.5e-05 22.4 0.0 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.4 NM_028301.4_1 - 1.9e-20 72.5 0.1 1.1e-07 31.9 0.0 4.5 2 2 3 5 5 5 5 Ankyrin repeats (many copies) SAM_1 PF00536.28 NM_028301.4_1 - 5e-12 46.0 0.0 1.2e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_028301.4_1 - 8.3e-11 41.7 0.0 1.7e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Macoilin PF09726.7 NM_028301.4_1 - 0.094 11.1 2.9 0.14 10.5 2.9 1.2 1 0 0 1 1 1 0 Transmembrane protein FH2 PF02181.21 NM_028301.4_1 - 0.51 9.3 2.4 1 8.3 2.4 1.4 1 0 0 1 1 1 0 Formin Homology 2 Domain YlqD PF11068.6 NM_028301.4_1 - 0.53 10.5 10.4 0.099 12.9 6.3 1.8 2 0 0 2 2 2 0 YlqD protein Lebercilin PF15619.4 NM_028301.4_1 - 1.4 8.4 9.5 0.51 9.8 6.4 1.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Filament PF00038.19 NM_001033177.2_2 - 2.7e-112 375.3 26.5 3.2e-112 375.0 26.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 NM_001033177.2_2 - 1.6e-36 125.8 45.3 1.6e-36 125.8 45.3 2.2 2 0 0 2 2 1 1 Keratin type II head CENP-F_leu_zip PF10473.7 NM_001033177.2_2 - 9e-07 28.9 22.4 0.00012 22.0 11.6 3.0 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.9 NM_001033177.2_2 - 0.00022 21.4 21.2 0.0014 18.7 0.4 2.6 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.10 NM_001033177.2_2 - 0.00033 20.6 29.7 0.0082 16.1 0.1 4.3 2 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 NM_001033177.2_2 - 0.00067 18.5 7.1 0.00067 18.5 7.1 3.3 1 1 2 3 3 3 2 Spc7 kinetochore protein AAA_13 PF13166.4 NM_001033177.2_2 - 0.0012 17.5 9.6 0.0012 17.5 9.6 1.8 2 1 0 2 2 2 1 AAA domain TSNAXIP1_N PF15739.3 NM_001033177.2_2 - 0.0046 17.2 1.2 0.0046 17.2 1.2 3.8 4 0 0 4 4 4 1 Translin-associated factor X-interacting N-terminus DUF4407 PF14362.4 NM_001033177.2_2 - 0.0058 15.9 16.6 0.18 11.0 0.1 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.10 NM_001033177.2_2 - 0.013 15.4 16.7 0.14 12.1 2.1 4.1 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Jnk-SapK_ap_N PF09744.7 NM_001033177.2_2 - 0.018 15.1 0.4 0.018 15.1 0.4 3.6 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 IncA PF04156.12 NM_001033177.2_2 - 0.023 14.3 29.2 0.054 13.2 13.4 3.6 1 1 1 2 2 2 0 IncA protein ADIP PF11559.6 NM_001033177.2_2 - 0.15 12.0 21.0 0.39 10.7 9.2 3.7 3 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding DUF1192 PF06698.9 NM_001033177.2_2 - 0.22 11.5 4.9 0.51 10.3 0.2 3.3 4 0 0 4 4 2 0 Protein of unknown function (DUF1192) She9_MDM33 PF05546.9 NM_001033177.2_2 - 0.24 11.1 6.0 5.2 6.7 0.0 2.5 2 0 0 2 2 2 0 She9 / Mdm33 family DUF2353 PF09789.7 NM_001033177.2_2 - 0.31 10.3 27.5 0.054 12.8 10.8 2.5 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) JIP_LZII PF16471.3 NM_001033177.2_2 - 0.45 10.6 17.2 2.7 8.1 0.7 4.9 5 0 0 5 5 5 0 JNK-interacting protein leucine zipper II T2SSM PF04612.10 NM_001033177.2_2 - 0.76 9.7 4.7 0.57 10.1 1.7 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Rootletin PF15035.4 NM_001033177.2_2 - 0.82 9.6 19.5 0.076 12.9 4.1 2.4 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion PRKG1_interact PF15898.3 NM_001033177.2_2 - 1 10.2 20.3 0.22 12.3 7.3 3.3 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF4618 PF15397.4 NM_001033177.2_2 - 1 8.6 25.8 0.08 12.2 7.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4618) Alanine_zipper PF11839.6 NM_001033177.2_2 - 1 9.5 9.5 0.041 14.0 3.1 2.0 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein bZIP_2 PF07716.13 NM_001033177.2_2 - 1.6 8.7 19.0 2 8.4 0.8 4.7 4 0 0 4 4 4 0 Basic region leucine zipper TRAF_BIRC3_bd PF16673.3 NM_001033177.2_2 - 3.5 7.4 7.0 8.4 6.1 1.1 3.2 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain DUF883 PF05957.11 NM_001033177.2_2 - 3.7 8.1 10.8 6.9 7.2 5.2 3.5 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF883) DUF4600 PF15372.4 NM_001033177.2_2 - 6.4 7.1 14.0 7.3 6.9 4.4 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4600) CHDCT2 PF08074.9 NM_001033177.2_2 - 7.6 6.5 11.4 0.64 10.0 0.5 2.6 2 1 0 2 2 2 0 CHDCT2 (NUC038) domain 7tm_2 PF00002.22 NM_001313928.1_1 - 2.8e-78 262.5 19.7 3.5e-78 262.2 19.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_001313928.1_1 - 0.021 15.0 0.3 0.048 13.8 0.3 1.6 1 0 0 1 1 1 0 Hormone receptor domain Glyco_trans_1_2 PF13524.4 NM_001313928.1_1 - 0.17 12.2 0.0 11 6.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferases group 1 Lectin_C PF00059.19 NM_001205363.1_1 - 3.8e-15 56.4 0.4 1e-14 55.0 0.4 1.8 1 0 0 1 1 1 1 Lectin C-type domain FA_desaturase PF00487.22 NM_001081664.2_2 - 2.8e-37 128.8 14.5 2.8e-37 128.8 14.5 1.6 2 0 0 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.26 NM_001081664.2_2 - 3.8e-20 71.7 0.0 7.2e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CHDNT PF08073.10 NM_001081664.2_2 - 0.059 13.1 0.0 0.28 11.0 0.0 2.1 2 0 0 2 2 2 0 CHDNT (NUC034) domain GMP_PDE_delta PF05351.9 NM_175352.4_3 - 6.8e-72 240.5 0.9 8.9e-72 240.1 0.9 1.1 1 0 0 1 1 1 1 GMP-PDE, delta subunit zf-H2C2_2 PF13465.4 NM_001013786.2_2 - 1.8e-34 116.5 57.9 1.4e-07 31.5 0.9 9.0 8 1 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001013786.2_2 - 2.7e-30 103.0 63.2 6.9e-05 23.0 0.1 8.3 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001013786.2_2 - 4.6e-15 54.9 70.2 0.004 17.7 0.2 8.6 8 0 0 8 8 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001013786.2_2 - 4.7e-07 29.5 48.1 0.16 11.8 0.1 7.8 7 0 0 7 7 7 5 C2H2-type zinc finger XPA_N PF01286.16 NM_001013786.2_2 - 8.7e-05 22.3 20.6 0.23 11.4 0.1 7.3 7 0 0 7 7 7 1 XPA protein N-terminal Zn-ribbon_8 PF09723.8 NM_001013786.2_2 - 0.0014 18.5 34.3 0.0034 17.3 0.4 5.6 2 1 5 7 7 7 5 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001013786.2_2 - 0.0094 16.1 26.9 1.6 9.0 0.6 6.5 7 0 0 7 7 6 3 Zinc-finger double-stranded RNA-binding MRP-S23 PF10484.7 NM_001013786.2_2 - 0.11 12.6 0.0 31 4.7 0.0 2.8 2 1 1 3 3 3 0 Mitochondrial ribosomal protein S23 FYVE PF01363.19 NM_001013786.2_2 - 0.21 11.6 32.8 0.073 13.1 9.5 4.9 1 1 3 4 4 4 0 FYVE zinc finger ADK_lid PF05191.12 NM_001013786.2_2 - 0.74 9.8 12.2 16 5.5 0.4 4.8 3 2 1 4 4 4 0 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 NM_001013786.2_2 - 1.4 9.6 30.5 2.3 8.9 1.1 4.8 2 1 2 4 4 4 0 zinc-ribbon family Peptidase_C1 PF00112.21 NM_022325.5_1 - 1.2e-49 169.3 12.9 1.7e-49 168.8 12.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.13 NM_022325.5_1 - 0.012 14.3 1.0 0.021 13.5 1.0 1.3 1 0 0 1 1 1 0 Peptidase C1-like family Y_phosphatase PF00102.25 NM_011877.2_1 - 4.2e-72 242.4 0.0 5.9e-72 241.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_M PF00373.16 NM_011877.2_1 - 4e-21 75.5 2.4 9.8e-21 74.2 2.4 1.7 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.8 NM_011877.2_1 - 3e-17 62.7 0.1 6.1e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_011877.2_1 - 5.8e-16 58.1 0.5 1.3e-15 56.9 0.2 1.8 2 0 0 2 2 2 1 FERM N-terminal domain DSPc PF00782.18 NM_011877.2_1 - 0.00043 20.0 0.0 0.00084 19.0 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_011877.2_1 - 0.004 17.0 0.0 0.0069 16.2 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family zf-BED PF02892.13 NM_181412.3_1 - 2.7e-61 203.2 28.3 7e-16 57.9 0.6 4.6 4 0 0 4 4 4 4 BED zinc finger Dimer_Tnp_hAT PF05699.12 NM_181412.3_1 - 1.7e-07 30.8 0.0 5.3e-07 29.2 0.0 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region PyrI_C PF02748.13 NM_181412.3_1 - 0.00074 19.2 5.4 2.2 8.1 0.1 4.3 4 0 0 4 4 4 3 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_9 PF14369.4 NM_181412.3_1 - 0.85 9.8 6.1 54 4.0 0.1 4.6 4 0 0 4 4 4 0 zinc-ribbon FGF PF00167.16 NM_008008.4_2 - 1.5e-47 160.7 2.1 2.4e-47 160.0 2.1 1.4 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 NM_008008.4_2 - 0.082 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Fascin domain WD40 PF00400.30 NM_145620.4_1 - 7.8e-28 96.0 14.9 5.9e-05 23.6 0.4 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_145620.4_1 - 6.4e-05 23.0 0.2 1.4 9.1 0.0 4.7 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain FRG1 PF06229.10 NM_145620.4_1 - 1.5 8.4 6.1 14 5.2 4.3 2.2 2 0 0 2 2 2 0 FRG1-like domain Peptidase_M28 PF04389.15 NM_001316729.1_1 - 9.9e-48 162.3 0.0 1.3e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 DUF3535 PF12054.6 NM_001080706.1_1 - 9.5e-132 440.2 11.2 3e-129 432.0 7.5 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF3535) SNF2_N PF00176.21 NM_001080706.1_1 - 2.8e-59 200.5 0.0 1e-58 198.6 0.0 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain HEAT PF02985.20 NM_001080706.1_1 - 1.2e-18 65.4 16.0 0.025 14.7 0.0 12.1 12 1 0 12 12 12 6 HEAT repeat Helicase_C PF00271.29 NM_001080706.1_1 - 3.8e-17 62.5 0.0 1.1e-16 61.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Vac14_Fab1_bd PF12755.5 NM_001080706.1_1 - 4.1e-10 40.0 0.8 0.055 13.9 0.0 5.2 3 2 1 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.4 NM_001080706.1_1 - 7.6e-09 35.7 2.3 0.76 10.1 0.3 6.6 5 1 2 7 7 7 5 HEAT repeats HEAT_EZ PF13513.4 NM_001080706.1_1 - 8.8e-05 22.7 11.4 0.0066 16.7 0.1 6.4 8 0 0 8 8 8 1 HEAT-like repeat TAF6_C PF07571.11 NM_001080706.1_1 - 0.00022 21.3 0.0 5.1 7.4 0.0 5.4 4 1 2 6 6 6 1 TAF6 C-terminal HEAT repeat domain UME PF08064.11 NM_001080706.1_1 - 0.1 12.4 2.8 31 4.4 0.0 4.7 4 0 0 4 4 4 0 UME (NUC010) domain LIF_OSM PF01291.15 NM_008501.2_2 - 2.6e-65 219.4 0.5 3.8e-65 218.8 0.5 1.3 1 0 0 1 1 1 1 LIF / OSM family Cystatin PF00031.19 NM_030059.2_2 - 1.5e-13 50.7 0.2 2.2e-13 50.1 0.2 1.3 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 NM_030059.2_2 - 0.05 13.8 0.1 0.073 13.3 0.1 1.2 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor Cathelicidins PF00666.15 NM_030059.2_2 - 0.1 12.8 0.2 0.16 12.2 0.2 1.2 1 0 0 1 1 1 0 Cathelicidin Rad51 PF08423.9 NM_011234.4_2 - 7.5e-129 428.3 0.1 9.7e-129 427.9 0.1 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 NM_011234.4_2 - 1.8e-09 37.3 0.0 2.6e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.19 NM_011234.4_2 - 1.8e-08 34.1 0.1 2.9e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.4 NM_011234.4_2 - 1.1e-07 32.2 0.5 2.9e-07 30.9 0.5 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.11 NM_011234.4_2 - 0.00067 18.9 1.3 0.002 17.4 1.3 1.8 1 1 0 1 1 1 1 KaiC Pkinase PF00069.23 NM_026952.2_1 - 7.5e-74 248.3 0.0 1.3e-73 247.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_026952.2_1 - 8.5e-34 116.9 0.0 1.3e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_026952.2_1 - 0.00054 19.2 0.0 0.0032 16.7 0.0 2.0 1 1 0 1 1 1 1 Kinase-like UVR PF02151.17 NM_177673.2_2 - 0.0015 18.1 15.5 0.14 11.8 5.4 2.9 2 0 0 2 2 2 2 UvrB/uvrC motif CLASP_N PF12348.6 NM_177673.2_2 - 0.0072 15.8 0.3 0.015 14.7 0.3 1.5 1 0 0 1 1 1 1 CLASP N terminal HEAT PF02985.20 NM_177673.2_2 - 0.11 12.7 0.2 37 4.8 0.1 3.1 2 0 0 2 2 2 0 HEAT repeat PRP21_like_P PF12230.6 NM_177673.2_2 - 1.2 8.8 9.9 5.3 6.7 0.1 3.3 2 1 1 3 3 3 0 Pre-mRNA splicing factor PRP21 like protein zf-Di19 PF05605.10 NM_177673.2_2 - 5.1 7.3 14.5 0.025 14.7 2.2 2.7 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Homeobox PF00046.27 NM_009123.2_1 - 7.4e-21 73.6 4.2 1.6e-20 72.6 4.2 1.6 1 0 0 1 1 1 1 Homeobox domain PDZ_1 PF12812.5 NM_009123.2_2 - 0.14 12.1 0.1 17 5.5 0.0 2.4 1 1 1 2 2 2 0 PDZ-like domain ANAPC8 PF04049.11 NM_178347.4_3 - 3.1e-25 88.7 10.7 3.9e-24 85.2 4.2 3.3 2 1 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.26 NM_178347.4_3 - 8.1e-22 76.0 32.3 1.8e-05 24.2 0.1 9.7 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_2 PF07719.15 NM_178347.4_3 - 5.9e-20 69.6 35.6 0.0014 18.4 0.1 10.7 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_8 PF13181.4 NM_178347.4_3 - 1.1e-14 53.2 25.8 0.00025 20.9 0.0 9.9 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.4 NM_178347.4_3 - 2.1e-10 40.8 11.6 0.0035 17.7 0.1 6.4 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.4 NM_178347.4_3 - 1.1e-09 37.7 10.2 5.1e-06 25.9 0.2 4.8 3 1 1 4 4 4 2 TPR repeat TPR_14 PF13428.4 NM_178347.4_3 - 2.5e-09 37.0 17.5 0.013 16.1 0.0 8.2 8 2 3 11 11 9 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_178347.4_3 - 2.6e-06 26.9 18.8 1.3 9.1 0.2 8.2 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_178347.4_3 - 3.9e-06 26.7 10.9 0.26 11.6 0.0 5.5 7 0 0 7 7 5 3 Tetratricopeptide repeat TPR_16 PF13432.4 NM_178347.4_3 - 1.9e-05 25.1 11.3 0.0066 17.0 0.0 6.0 5 1 1 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_178347.4_3 - 3.7e-05 23.7 31.9 0.0039 17.2 0.1 6.0 5 1 2 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 NM_178347.4_3 - 0.00073 19.9 18.6 4.7 7.9 0.0 8.0 9 0 0 9 9 8 2 Tetratricopeptide repeat DUF772 PF05598.9 NM_178347.4_3 - 0.013 15.3 0.1 0.039 13.9 0.1 1.7 1 0 0 1 1 1 0 Transposase domain (DUF772) TPR_12 PF13424.4 NM_178347.4_3 - 0.026 14.7 25.1 0.8 9.9 0.1 7.2 4 2 5 9 9 8 0 Tetratricopeptide repeat TPR_9 PF13371.4 NM_178347.4_3 - 0.048 13.7 4.2 0.069 13.2 0.2 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_178347.4_3 - 0.11 12.3 10.3 27 4.7 0.0 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_15 PF13429.4 NM_178347.4_3 - 0.26 10.3 5.9 0.33 10.0 1.5 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat IMUP PF15761.3 NM_001081684.2_2 - 0.00065 20.2 4.5 0.0013 19.3 4.5 1.4 1 0 0 1 1 1 1 Immortalisation up-regulated protein BTB PF00651.29 NM_001081684.2_3 - 1.5e-24 86.2 0.1 2.6e-24 85.5 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 NM_001081684.2_3 - 5.2e-08 32.8 82.3 0.0029 17.8 1.0 10.0 11 0 0 11 11 11 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001081684.2_3 - 0.00011 22.6 92.2 0.15 12.8 0.6 11.3 11 0 0 11 11 11 7 C2H2-type zinc finger zf-CHCC PF10276.7 NM_001081684.2_3 - 0.18 11.7 3.8 2.6 8.1 0.2 3.1 2 0 0 2 2 2 0 Zinc-finger domain zf-C2HE PF16278.3 NM_001081684.2_3 - 0.42 11.0 0.0 0.42 11.0 0.0 6.7 5 2 1 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_2 PF13465.4 NM_001081684.2_3 - 4 7.9 0.0 0.011 16.0 4.5 11.8 13 1 0 13 13 13 0 Zinc-finger double domain Acyltransferase PF01553.19 NM_018862.3_1 - 6.6e-33 113.1 0.0 9.5e-33 112.5 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase zf-LITAF-like PF10601.7 NM_018862.3_1 - 0.078 13.1 3.5 0.34 11.1 1.9 3.0 3 1 0 3 3 3 0 LITAF-like zinc ribbon domain HMG_box PF00505.17 NM_001289464.1_2 - 3.2e-25 88.2 1.4 5.1e-25 87.6 1.4 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box Sox17_18_mid PF12067.6 NM_001289464.1_2 - 3.9e-19 68.3 1.9 3.9e-19 68.3 1.9 2.2 2 0 0 2 2 2 1 Sox 17/18 central domain HMG_box_2 PF09011.8 NM_001289464.1_2 - 2.7e-10 40.6 1.1 2.7e-10 40.6 1.1 1.6 2 0 0 2 2 2 1 HMG-box domain Sds3 PF08598.9 NM_001122666.2_1 - 7.7e-19 68.4 10.2 1.3e-18 67.7 10.2 1.3 1 0 0 1 1 1 1 Sds3-like Exonuc_VII_L PF02601.13 NM_001122666.2_1 - 0.79 9.1 8.1 1.2 8.5 8.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_15 PF13175.4 NM_001122666.2_1 - 1.5 8.2 11.6 2.2 7.6 11.6 1.1 1 0 0 1 1 1 0 AAA ATPase domain Retrotrans_gag PF03732.15 NM_001122666.2_1 - 4 7.7 7.1 6.6 7.0 6.5 1.7 1 1 0 1 1 1 0 Retrotransposon gag protein Asp PF00026.21 NM_008437.1_1 - 1.1e-106 356.7 0.0 1.3e-106 356.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 NM_008437.1_1 - 7.6e-12 45.7 0.1 3e-09 37.3 0.1 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal PH PF00169.27 NM_023900.2_3 - 1.9e-08 34.6 0.0 5.1e-08 33.2 0.0 1.7 2 0 0 2 2 2 1 PH domain PH_13 PF16652.3 NM_023900.2_3 - 0.09 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain SIR2 PF02146.15 NM_001122765.1_3 - 1.1e-57 194.7 0.0 1.5e-57 194.3 0.0 1.2 1 0 0 1 1 1 1 Sir2 family YdjO PF14169.4 NM_001122765.1_3 - 0.0018 17.8 1.7 0.0041 16.7 1.7 1.5 1 0 0 1 1 1 1 Cold-inducible protein YdjO RecQ_Zn_bind PF16124.3 NM_001122765.1_3 - 2.2 8.9 4.4 45 4.7 1.1 2.7 2 0 0 2 2 2 0 RecQ zinc-binding 7tm_1 PF00001.19 NM_001308501.1_3 - 1.5e-36 125.9 8.7 3e-36 124.9 8.7 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 NM_001308501.1_3 - 1.2e-09 37.8 18.5 2.9e-09 36.5 18.5 1.7 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.7 NM_001308501.1_3 - 1.5e-07 31.0 14.1 3.6e-07 29.7 14.1 1.6 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4617 PF15395.4 NM_001289661.1_1 - 0 1333.7 78.5 0 1333.7 78.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4617) IL11 PF07400.9 NM_001289661.1_3 - 0.012 15.4 0.2 0.018 14.9 0.2 1.1 1 0 0 1 1 1 0 Interleukin 11 Mon2_C PF16206.3 NM_001163025.1_1 - 0 1335.6 0.5 0 1334.6 0.7 1.3 2 0 0 2 2 2 1 C-terminal region of Mon2 protein DCB PF16213.3 NM_001163025.1_1 - 3.1e-69 232.0 7.8 1e-68 230.4 7.8 2.0 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.5 NM_001163025.1_1 - 4.2e-54 182.7 2.7 4.2e-54 182.7 2.7 2.5 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.8 NM_001163025.1_1 - 1.8e-18 66.0 0.2 1.7e-16 59.7 0.0 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) HEAT PF02985.20 NM_001163025.1_1 - 0.0029 17.6 1.3 40 4.7 0.0 5.0 4 0 0 4 4 4 0 HEAT repeat CHGN PF05679.14 NM_001252623.1_1 - 2.9e-82 277.0 0.1 3.7e-82 276.7 0.1 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.12 NM_001252623.1_1 - 1e-08 34.6 1.1 2.1e-08 33.5 1.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 NM_001252623.1_1 - 0.0024 17.3 0.3 0.03 13.7 0.3 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 IncA PF04156.12 NM_001252623.1_1 - 0.034 13.8 0.2 0.034 13.8 0.2 1.8 2 0 0 2 2 2 0 IncA protein FAM184 PF15665.3 NM_001252623.1_1 - 0.093 12.4 1.2 0.19 11.3 1.2 1.5 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B Fibrinogen_C PF00147.16 NM_133862.2_2 - 9.1e-95 316.5 9.6 1.2e-94 316.1 9.6 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fib_alpha PF08702.8 NM_133862.2_2 - 1.1e-48 164.9 4.9 1.8e-48 164.2 4.9 1.3 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Spc29 PF17082.3 NM_133862.2_2 - 0.0036 17.1 0.7 0.016 14.9 0.7 1.9 2 0 0 2 2 2 1 Spindle Pole Component 29 TMF_DNA_bd PF12329.6 NM_133862.2_2 - 0.8 9.6 4.3 1.7 8.6 4.3 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding WD40 PF00400.30 NM_001172114.1_2 - 5.5e-31 106.0 23.8 2.2e-08 34.5 0.8 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat WD40_like PF17005.3 NM_001172114.1_2 - 1.9e-06 27.3 1.0 4.6e-06 26.1 1.0 1.6 1 1 0 1 1 1 1 WD40-like domain zf-RING_UBOX PF13445.4 NM_001172114.1_2 - 2.4e-06 27.3 8.5 1.3e-05 24.9 8.5 2.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_001172114.1_2 - 3.5e-05 23.5 10.3 3.5e-05 23.5 10.3 3.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001172114.1_2 - 4.1e-05 23.2 14.4 4.1e-05 23.2 14.4 3.4 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) Sina PF03145.14 NM_001172114.1_2 - 8.2e-05 22.5 10.9 0.00072 19.5 0.4 2.4 1 1 1 2 2 2 1 Seven in absentia protein family PKcGMP_CC PF16808.3 NM_001172114.1_2 - 0.00016 21.3 1.1 0.0065 16.2 0.0 2.4 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase zf-C3HC4_4 PF15227.4 NM_001172114.1_2 - 0.00021 21.3 7.3 0.00021 21.3 7.3 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 NM_001172114.1_2 - 0.00033 20.3 11.6 0.00033 20.3 11.6 2.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Nup160 PF11715.6 NM_001172114.1_2 - 0.0012 17.5 4.5 0.0037 15.8 0.3 3.0 3 1 1 4 4 4 1 Nucleoporin Nup120/160 DUF4164 PF13747.4 NM_001172114.1_2 - 0.0078 16.3 2.7 0.013 15.6 2.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4164) zf-RING_5 PF14634.4 NM_001172114.1_2 - 0.011 15.6 13.4 0.011 15.6 13.4 3.1 2 0 0 2 2 2 0 zinc-RING finger domain Tropomyosin_1 PF12718.5 NM_001172114.1_2 - 0.044 13.8 2.7 0.069 13.1 2.7 1.2 1 0 0 1 1 1 0 Tropomyosin like Filament PF00038.19 NM_001172114.1_2 - 0.067 12.6 2.2 0.1 12.0 2.2 1.2 1 0 0 1 1 1 0 Intermediate filament protein DUF1640 PF07798.9 NM_001172114.1_2 - 0.098 12.6 1.8 0.18 11.7 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF641 PF04859.10 NM_001172114.1_2 - 0.11 12.7 0.3 0.22 11.8 0.3 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF1664 PF07889.10 NM_001172114.1_2 - 0.13 12.1 0.5 1.2 9.0 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.14 NM_001172114.1_2 - 0.13 12.6 3.4 0.37 11.2 3.4 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 HrpB7 PF09486.8 NM_001172114.1_2 - 0.15 12.3 0.1 0.26 11.5 0.1 1.3 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) KxDL PF10241.7 NM_001172114.1_2 - 0.51 10.5 2.3 0.86 9.8 1.2 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein IncA PF04156.12 NM_001172114.1_2 - 0.53 9.9 2.3 0.9 9.2 2.3 1.3 1 0 0 1 1 1 0 IncA protein Bacillus_HBL PF05791.9 NM_001172114.1_2 - 0.55 9.8 1.7 0.9 9.1 1.7 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) zf-TRAF PF02176.16 NM_001172114.1_2 - 0.7 10.5 13.9 0.073 13.6 8.1 2.5 2 0 0 2 2 1 0 TRAF-type zinc finger zf-Nse PF11789.6 NM_001172114.1_2 - 0.81 9.4 10.7 0.66 9.7 5.5 2.6 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit SlyX PF04102.10 NM_001172114.1_2 - 2 8.9 4.1 2.4 8.7 1.0 2.2 1 1 1 2 2 2 0 SlyX Caldesmon PF02029.13 NM_001136071.2_1 - 3e-28 98.7 30.8 7.4e-25 87.5 3.1 2.4 1 1 0 2 2 2 2 Caldesmon ATP-synt_C PF00137.19 NM_026468.2_1 - 2.9e-11 43.4 12.4 4.9e-11 42.7 12.4 1.4 1 0 0 1 1 1 1 ATP synthase subunit C Serpin PF00079.18 NM_009251.1_3 - 9.9e-117 390.2 0.3 1.2e-116 389.9 0.3 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Peptidase_M10 PF00413.22 NM_008607.2_3 - 1.2e-65 220.1 0.0 1.8e-65 219.4 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 NM_008607.2_3 - 5.2e-42 141.4 3.4 7.3e-11 41.7 0.1 4.3 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 NM_008607.2_3 - 1e-10 41.5 0.0 1.7e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.4 NM_008607.2_3 - 0.0035 17.7 0.0 0.0063 16.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_008607.2_3 - 0.0089 15.6 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.22 NM_008607.2_3 - 0.026 14.0 0.1 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.4 NM_008607.2_3 - 0.049 13.6 0.2 0.082 12.9 0.2 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4953 PF16313.3 NM_008607.2_3 - 0.21 10.7 0.1 0.34 9.9 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Neuromodulin PF06614.9 NM_008083.2_3 - 1.2e-58 198.0 61.0 1.2e-58 198.0 61.0 2.3 1 1 1 2 2 2 1 Neuromodulin Neuromodulin_N PF10580.7 NM_008083.2_3 - 3.4e-18 64.9 6.1 1.8e-17 62.6 6.1 2.4 1 0 0 1 1 1 1 Gap junction protein N-terminal region IQ PF00612.25 NM_008083.2_3 - 1.8e-06 27.1 0.4 4.5e-06 25.8 0.4 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif UPF0193 PF05250.9 NM_001310581.1_2 - 0.0026 17.5 0.0 0.0037 16.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) UPF0193 PF05250.9 NM_001310581.1_3 - 7.9e-46 156.4 15.2 6.5e-39 133.8 9.5 2.1 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0193) AAA_23 PF13476.4 NM_001310581.1_3 - 1.1 9.6 4.5 1.4 9.2 4.5 1.1 1 0 0 1 1 1 0 AAA domain ubiquitin PF00240.21 NM_001033865.1_1 - 2.7e-34 116.6 0.3 4.5e-34 115.9 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.17 NM_001033865.1_1 - 1e-26 92.7 4.6 1e-26 92.7 4.6 2.0 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.6 NM_001033865.1_1 - 2.1e-16 59.4 0.4 3.7e-16 58.6 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 NM_001033865.1_1 - 1.5e-05 25.2 0.3 7.4e-05 23.0 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 NM_001033865.1_1 - 0.00046 20.1 0.6 0.00094 19.1 0.6 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 NM_001033865.1_1 - 0.019 15.4 0.6 0.032 14.7 0.6 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain HATPase_c PF02518.24 NM_001033865.1_1 - 0.12 12.8 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF775 PF05603.10 NM_001291289.1_2 - 1.5e-17 63.7 0.0 2.4e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Menin PF05053.11 NM_001168489.1_3 - 6e-276 917.1 1.5 8.6e-251 833.9 0.0 2.1 1 1 0 2 2 2 2 Menin DnaJ PF00226.29 NM_178055.4_2 - 2e-26 91.8 5.0 3e-26 91.2 5.0 1.3 1 0 0 1 1 1 1 DnaJ domain UIM PF02809.18 NM_178055.4_2 - 0.0013 18.3 8.5 0.0016 18.1 4.0 2.5 2 0 0 2 2 2 1 Ubiquitin interaction motif CCER1 PF15482.4 NM_174993.2_3 - 0.97 9.1 10.2 0.095 12.4 2.7 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing glutamate-rich protein family 1 4HBT PF03061.20 NM_019736.4_3 - 4.9e-06 26.7 0.0 0.11 12.8 0.0 2.3 2 0 0 2 2 2 2 Thioesterase superfamily Phtf-FEM1B_bdg PF12129.6 NM_172992.3_1 - 1e-72 242.9 0.3 3.1e-72 241.3 0.3 1.9 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor WD40 PF00400.30 NM_001252463.1_1 - 5.1e-29 99.8 14.7 0.00026 21.6 0.0 9.4 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001252463.1_1 - 1.6e-08 34.6 0.4 0.024 14.8 0.0 4.6 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 NM_001252463.1_1 - 0.0036 16.2 0.3 4.2 6.1 0.0 3.5 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 NM_001252463.1_1 - 0.021 13.3 1.5 2.7 6.4 0.0 3.3 3 1 1 4 4 4 0 Nucleoporin Nup120/160 Hira PF07569.9 NM_001252463.1_1 - 0.13 11.9 0.1 2.9 7.4 0.0 2.3 1 1 1 2 2 2 0 TUP1-like enhancer of split PhoLip_ATPase_C PF16212.3 NM_001293667.1_2 - 9.4e-77 258.0 30.0 9.4e-77 258.0 30.0 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 NM_001293667.1_2 - 4.5e-23 80.7 0.3 1.5e-22 79.0 0.3 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.18 NM_001293667.1_2 - 5.5e-11 42.1 0.0 2.8e-10 39.7 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.24 NM_001293667.1_2 - 7.8e-10 39.3 0.2 8.1e-05 22.9 0.1 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.4 NM_001293667.1_2 - 9e-10 38.4 0.0 3.6e-09 36.5 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.10 NM_001293667.1_2 - 0.0035 17.0 0.0 0.17 11.5 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 NM_001293667.1_2 - 0.037 14.3 0.1 1.6 9.0 0.1 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Ig_3 PF13927.4 NM_021893.3_3 - 4e-11 43.2 0.1 7e-05 23.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_021893.3_3 - 2.9e-08 33.7 0.0 1.4e-07 31.5 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 NM_021893.3_3 - 4.6e-07 29.9 0.1 0.024 14.9 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_021893.3_3 - 8e-07 28.9 0.0 0.016 15.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 NM_021893.3_3 - 1.2e-05 25.2 0.0 0.0065 16.5 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 NM_021893.3_3 - 0.00013 21.9 0.3 0.00025 20.9 0.3 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Spy1 PF11357.6 NM_029048.3_1 - 8.2e-59 197.5 3.8 1.2e-58 196.9 3.8 1.2 1 0 0 1 1 1 1 Cell cycle regulatory protein Serpin PF00079.18 NM_008871.2_2 - 1.7e-105 353.3 2.8 2e-105 353.0 2.8 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sulfotransfer_1 PF00685.25 NM_018763.2_1 - 4.4e-23 82.0 0.0 6.7e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_018763.2_1 - 3.9e-11 43.6 0.1 2.4e-07 31.2 0.3 3.2 2 1 0 2 2 2 2 Sulfotransferase family SPRY PF00622.26 NM_001290505.1_3 - 7.1e-15 55.1 0.0 1.2e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_001290505.1_3 - 1.9e-10 40.0 0.0 5.4e-10 38.6 0.0 1.8 1 0 0 1 1 1 1 SPRY-associated domain zf-B_box PF00643.22 NM_001290505.1_3 - 7e-09 35.6 0.8 7e-09 35.6 0.8 4.6 4 0 0 4 4 3 2 B-box zinc finger fn3 PF00041.19 NM_001290505.1_3 - 2.3e-08 34.1 0.3 4.9e-08 33.1 0.3 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_UBOX PF13445.4 NM_001290505.1_3 - 6.2e-07 29.2 9.5 6.2e-07 29.2 9.5 4.3 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_001290505.1_3 - 1.1e-06 28.3 8.5 1.1e-06 28.3 8.5 4.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001290505.1_3 - 4.1e-06 26.4 11.7 4.1e-06 26.4 11.7 4.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001290505.1_3 - 1.4e-05 25.1 24.8 6.6e-05 22.9 11.5 4.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.4 NM_001290505.1_3 - 2e-05 24.5 12.3 2e-05 24.5 12.3 4.5 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 NM_001290505.1_3 - 0.00068 19.3 12.2 0.00068 19.3 12.2 6.1 10 1 0 10 10 8 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001290505.1_3 - 0.0036 17.1 10.8 0.0036 17.1 10.8 3.9 3 0 0 3 3 3 1 zinc-RING finger domain Pur_ac_phosph_N PF16656.3 NM_001290505.1_3 - 0.0091 16.4 0.3 0.018 15.5 0.3 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 NM_001290505.1_3 - 0.0099 16.2 0.0 0.025 14.9 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2369) Serine_rich PF08824.8 NM_001290505.1_3 - 0.73 9.7 5.4 2.6 7.9 5.4 1.8 1 1 0 1 1 1 0 Serine rich protein interaction domain GOLD_2 PF13897.4 NM_001033475.3_3 - 5.4e-69 230.9 1.7 8.5e-69 230.2 1.7 1.3 1 0 0 1 1 1 1 Golgi-dynamics membrane-trafficking C2 PF00168.28 NM_001281999.1_1 - 7e-39 132.1 0.0 2.5e-20 72.6 0.0 2.2 2 0 0 2 2 2 2 C2 domain RasGAP PF00616.17 NM_001281999.1_2 - 1.5e-40 139.0 0.0 2.2e-40 138.5 0.0 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase PH PF00169.27 NM_001281999.1_2 - 1.4e-14 54.4 0.0 2.4e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 PH domain BTK PF00779.17 NM_001281999.1_2 - 1.1e-12 47.4 5.3 1.1e-12 47.4 5.3 2.3 3 0 0 3 3 3 1 BTK motif TMIE PF16038.3 NM_001162896.1_1 - 0.022 14.5 0.4 0.039 13.7 0.4 1.4 1 0 0 1 1 1 0 TMIE protein ETRAMP PF09716.8 NM_001162896.1_1 - 0.068 13.1 1.7 0.14 12.1 1.7 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) FAM176 PF14851.4 NM_001162896.1_1 - 0.13 11.8 0.1 0.27 10.8 0.1 1.4 1 0 0 1 1 1 0 FAM176 family DUF4672 PF15716.3 NM_001162896.1_2 - 0.32 10.5 2.6 0.58 9.6 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) VIT PF08487.8 NM_018746.4_3 - 2.8e-32 111.1 1.5 5.7e-32 110.2 1.5 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.26 NM_018746.4_3 - 2.6e-28 99.3 0.1 6.1e-28 98.1 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 NM_018746.4_3 - 2.9e-16 59.6 0.0 5.2e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 NM_018746.4_3 - 2.8e-13 50.3 0.1 6.1e-13 49.2 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain ITI_HC_C PF06668.10 NM_018746.4_3 - 5.4e-09 35.8 0.0 2.4e-08 33.7 0.0 2.0 1 1 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus vWA-TerF-like PF10138.7 NM_018746.4_3 - 2.5e-06 27.6 0.0 4.1e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_CoxE PF05762.12 NM_018746.4_3 - 0.0055 16.0 0.0 0.031 13.5 0.0 2.0 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein Collagen PF01391.16 NM_018746.4_3 - 0.017 14.7 7.5 0.033 13.8 7.5 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Peptidase_S49_N PF08496.8 NM_018746.4_3 - 0.023 14.7 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Spectrin PF00435.19 NM_018746.4_3 - 0.13 12.7 3.5 10 6.5 0.2 2.6 2 0 0 2 2 2 0 Spectrin repeat P66_CC PF16563.3 NM_001286450.1_3 - 9.9e-20 69.7 11.3 1.9e-19 68.8 11.3 1.5 1 0 0 1 1 1 1 Coiled-coil and interaction region of P66A and P66B with MBD2 GATA PF00320.25 NM_001286450.1_3 - 0.00015 21.2 6.6 0.00042 19.7 6.6 1.9 1 0 0 1 1 1 1 GATA zinc finger SWIB PF02201.16 NM_001302804.1_2 - 1.2e-06 28.2 0.0 2.1e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain zf-C3HC4_3 PF13920.4 NM_001302804.1_3 - 3.3e-09 36.3 4.7 3.3e-09 36.3 4.7 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RanBP PF00641.16 NM_001302804.1_3 - 4.6e-08 32.1 6.2 4.6e-08 32.1 6.2 2.2 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others Cript PF10235.7 NM_001302804.1_3 - 4.4 7.8 9.2 0.089 13.2 1.5 2.0 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT Siva PF05458.10 NM_001161737.1_2 - 3e-48 163.6 20.8 3.4e-30 104.9 19.6 2.0 1 1 1 2 2 2 2 Cd27 binding protein (Siva) 7tm_4 PF13853.4 NM_147066.2_1 - 8.2e-49 166.7 11.5 1.1e-48 166.3 11.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147066.2_1 - 1.3e-19 70.4 11.7 2.6e-19 69.4 11.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) YoqO PF14037.4 NM_001011662.2_2 - 0.08 13.3 0.1 0.13 12.6 0.1 1.2 1 0 0 1 1 1 0 YoqO-like protein 7tm_4 PF13853.4 NM_001011662.2_3 - 2.5e-50 171.6 21.5 3.4e-50 171.2 21.5 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011662.2_3 - 5.4e-18 65.0 19.3 1.2e-17 63.9 19.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011662.2_3 - 0.00029 20.2 25.1 0.00029 20.2 25.1 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx ApoO PF09769.7 NM_026565.3_2 - 1.6e-35 121.8 0.0 2.5e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Apolipoprotein O DUF3504 PF12012.6 NM_175143.5_2 - 3.3e-61 205.8 0.7 3.3e-61 205.8 0.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3504) CARD PF00619.19 NM_175143.5_2 - 0.0054 16.6 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Caspase recruitment domain Lipocalin PF00061.21 NM_001126321.2_2 - 1.3e-19 70.7 2.8 1.5e-19 70.5 2.8 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family RNase_PH PF01138.19 NM_175399.4_1 - 2.3e-33 115.4 0.0 3.4e-33 114.8 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 NM_175399.4_1 - 3.3e-08 33.3 0.0 5.5e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 7tm_4 PF13853.4 NM_146981.1_1 - 7.6e-45 153.7 19.3 9.4e-45 153.4 19.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146981.1_1 - 1.2e-15 57.3 24.5 4.7e-15 55.4 24.5 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Curto_V3 PF07436.9 NM_146981.1_1 - 0.14 12.3 0.7 0.35 11.0 0.7 1.7 1 0 0 1 1 1 0 Curtovirus V3 protein MIB_HERC2 PF06701.11 NM_145124.3_2 - 7.5e-47 157.3 24.7 3.8e-23 81.4 6.3 2.7 2 0 0 2 2 2 2 Mib_herc2 Ank_2 PF12796.5 NM_145124.3_2 - 1.7e-40 137.4 5.7 9.6e-12 45.2 0.4 6.2 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_145124.3_2 - 2e-37 126.5 14.8 8.1e-10 38.7 0.1 6.8 2 1 4 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_145124.3_2 - 5.9e-34 115.9 3.1 4.2e-08 33.5 0.0 6.5 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 NM_145124.3_2 - 1.7e-28 97.6 8.6 5.3e-06 26.5 0.0 9.3 9 0 0 9 9 9 6 Ankyrin repeat Ank_3 PF13606.4 NM_145124.3_2 - 5.1e-26 87.8 6.2 0.00016 21.7 0.1 8.6 8 0 0 8 8 8 7 Ankyrin repeat zf-C3HC4_3 PF13920.4 NM_145124.3_2 - 5.7e-11 42.0 26.2 3.7e-07 29.8 8.5 3.7 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) ZZ PF00569.15 NM_145124.3_2 - 2.6e-08 33.4 11.4 2.6e-08 33.4 11.4 3.0 4 0 0 4 4 4 1 Zinc finger, ZZ type zf-C3HC4_2 PF13923.4 NM_145124.3_2 - 0.0037 16.9 9.3 0.0037 16.9 9.3 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.22 NM_001163769.1_2 - 8.9e-14 50.9 16.3 7.2e-07 28.8 2.6 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.20 NM_001163769.1_2 - 1.2e-06 28.2 0.0 1.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.3 NM_001163769.1_2 - 6.1e-05 23.5 7.5 0.03 14.9 0.1 2.7 2 1 1 3 3 3 2 Torus domain KMP11 PF03037.14 NM_001163769.1_2 - 0.036 14.7 0.6 1.2 9.9 0.4 2.3 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 Nup35_RRM_2 PF14605.4 NM_001163769.1_2 - 0.05 13.4 0.0 0.2 11.5 0.1 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif zf-CCCH_3 PF15663.3 NM_001163769.1_2 - 0.19 11.9 6.2 1.4 9.1 0.5 2.4 2 0 0 2 2 2 0 Zinc-finger containing family Ank_2 PF12796.5 NM_001012518.3_3 - 4.7e-46 155.2 1.3 1.5e-15 57.4 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001012518.3_3 - 2.2e-40 136.4 6.1 1.9e-12 47.3 0.0 5.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001012518.3_3 - 1.4e-33 110.9 3.3 2.1e-05 24.4 0.0 8.3 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.4 NM_001012518.3_3 - 1.1e-32 111.4 6.6 1.2e-10 41.3 0.0 6.2 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.28 NM_001012518.3_3 - 6.5e-32 108.5 3.4 5.1e-05 23.4 0.0 7.4 7 0 0 7 7 7 6 Ankyrin repeat SET PF00856.26 NM_001012518.3_3 - 1.4e-21 77.5 0.0 1.4e-21 77.5 0.0 3.6 4 0 0 4 4 4 1 SET domain Pre-SET PF05033.14 NM_001012518.3_3 - 5.1e-16 59.1 13.3 5.1e-16 59.1 13.3 3.8 4 0 0 4 4 4 1 Pre-SET motif Pkinase PF00069.23 NM_001286002.1_1 - 9.3e-07 28.3 0.0 4.3e-06 26.1 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001286002.1_1 - 0.01 15.0 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase DUF2603 PF10788.7 NM_001286002.1_3 - 0.16 11.8 0.5 0.26 11.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2603) Ank_2 PF12796.5 NM_009671.5_3 - 1.7e-74 246.3 27.7 3.2e-14 53.1 0.0 11.6 3 2 9 13 13 13 13 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_009671.5_3 - 1.8e-59 197.3 25.6 5.4e-09 36.3 0.0 15.5 6 4 8 16 16 16 10 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_009671.5_3 - 3.1e-57 183.7 31.1 4.4e-05 23.4 0.0 20.0 22 0 0 22 22 22 14 Ankyrin repeat Ank PF00023.28 NM_009671.5_3 - 1.3e-54 180.2 31.9 2.8e-07 30.5 0.0 18.7 20 1 0 20 20 20 11 Ankyrin repeat Ank_5 PF13857.4 NM_009671.5_3 - 2.6e-47 158.0 27.6 7.3e-07 29.3 0.0 13.6 11 2 3 14 14 14 9 Ankyrin repeats (many copies) FYVE PF01363.19 NM_009671.5_3 - 3.1e-16 59.1 19.0 4e-15 55.6 10.5 2.8 2 0 0 2 2 2 2 FYVE zinc finger BTB PF00651.29 NM_009671.5_3 - 4.7e-15 55.6 0.0 1.1e-14 54.4 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 NM_009671.5_3 - 0.0017 18.3 0.3 0.004 17.1 0.3 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch HNH_3 PF13392.4 NM_001282041.1_1 - 0.046 13.4 0.0 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 HNH endonuclease Hydrolase_3 PF08282.10 NM_001282041.1_1 - 0.19 11.3 0.0 0.22 11.1 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PMM PF03332.11 NM_001282041.1_2 - 6.3e-53 179.7 0.0 8.8e-53 179.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase TPR_2 PF07719.15 NM_028417.1_1 - 9.9e-08 31.4 8.8 2.7e-05 23.8 0.4 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_028417.1_1 - 3.3e-05 24.2 4.7 0.0001 22.7 0.3 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.26 NM_028417.1_1 - 5.9e-05 22.6 5.3 0.00081 19.0 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_028417.1_1 - 0.00067 20.0 3.4 0.0022 18.4 0.5 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat CAF1 PF04857.18 NM_028417.1_1 - 0.00082 18.5 0.1 0.00099 18.2 0.1 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease TPR_16 PF13432.4 NM_028417.1_1 - 0.0046 17.5 4.1 0.011 16.3 0.2 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat DUF3405 PF11885.6 NM_028417.1_1 - 0.012 14.2 0.4 0.012 14.1 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) TPR_9 PF13371.4 NM_028417.1_1 - 0.029 14.4 0.1 0.076 13.1 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_028417.1_1 - 0.037 14.0 0.4 0.037 14.0 0.4 2.9 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.4 NM_028417.1_1 - 0.038 14.2 0.9 0.038 14.2 0.9 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat EOS1 PF12326.6 NM_028417.1_1 - 0.066 13.0 0.2 0.066 13.0 0.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein TPR_19 PF14559.4 NM_028417.1_1 - 0.1 13.0 1.0 0.3 11.5 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_028417.1_1 - 0.14 12.3 3.9 0.23 11.5 0.5 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.4 NM_028417.1_1 - 0.17 11.8 5.1 2 8.5 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Presenilin PF01080.15 NM_028417.1_1 - 0.52 8.9 2.9 0.63 8.6 2.9 1.1 1 0 0 1 1 1 0 Presenilin DUF4770 PF15994.3 NM_028417.1_1 - 4.8 7.3 21.3 7.6 6.6 21.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RNA_pol_Rpc4 PF05132.12 NM_028417.1_1 - 5.6 7.3 16.9 9.8 6.5 16.9 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 EOS1 PF12326.6 NM_028417.1_3 - 0.087 12.6 0.9 0.091 12.6 0.9 1.1 1 0 0 1 1 1 0 N-glycosylation protein Ribosomal_S18 PF01084.18 NM_026768.3_3 - 3.2e-16 59.1 0.0 5.7e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 Serglycin PF04360.10 NM_176940.5_1 - 1.2 8.9 4.1 2.2 8.1 4.1 1.3 1 0 0 1 1 1 0 Serglycin WD40 PF00400.30 NM_176940.5_2 - 6.1e-21 74.2 2.1 0.00035 21.2 0.0 8.5 8 0 0 8 8 8 4 WD domain, G-beta repeat NACHT PF05729.10 NM_176940.5_2 - 1.3e-10 41.3 0.7 3.6e-10 39.9 0.3 1.9 2 0 0 2 2 2 1 NACHT domain ANAPC4_WD40 PF12894.5 NM_176940.5_2 - 2.9e-09 37.0 0.1 3.8e-05 23.8 0.2 4.8 5 1 1 6 6 5 1 Anaphase-promoting complex subunit 4 WD40 domain AAA_16 PF13191.4 NM_176940.5_2 - 1.1e-05 25.8 1.5 2.6e-05 24.5 0.3 2.3 2 1 0 2 2 2 1 AAA ATPase domain DUF4062 PF13271.4 NM_176940.5_2 - 8.2e-05 22.8 0.1 0.00048 20.3 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) AAA_22 PF13401.4 NM_176940.5_2 - 0.00024 21.2 0.0 0.00057 20.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain Nup160 PF11715.6 NM_176940.5_2 - 0.0033 16.0 0.1 0.26 9.7 0.0 2.7 2 1 0 2 2 2 1 Nucleoporin Nup120/160 AAA PF00004.27 NM_176940.5_2 - 0.007 16.7 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.15 NM_176940.5_2 - 0.018 14.7 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.20 NM_176940.5_2 - 0.021 15.1 0.0 0.49 10.7 0.0 2.4 2 0 0 2 2 2 0 RNA helicase RuvB_N PF05496.10 NM_176940.5_2 - 0.072 12.2 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus ATPase_2 PF01637.16 NM_176940.5_2 - 0.15 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RBD-FIP PF09457.8 NM_001285916.1_1 - 0.039 13.7 3.2 0.085 12.7 3.2 1.5 1 0 0 1 1 1 0 FIP domain DUF972 PF06156.11 NM_001285916.1_1 - 0.54 10.8 3.8 1 9.9 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) bZIP_Maf PF03131.15 NM_010756.3_2 - 1.1e-32 112.2 11.7 1.1e-32 112.2 11.7 2.2 2 0 0 2 2 2 1 bZIP Maf transcription factor DivIC PF04977.13 NM_010756.3_2 - 0.00066 19.3 6.4 0.00066 19.3 6.4 3.1 2 1 1 3 3 3 1 Septum formation initiator DUF1192 PF06698.9 NM_010756.3_2 - 0.015 15.2 6.0 0.16 11.9 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) ThrE_2 PF12821.5 NM_010756.3_2 - 0.11 12.5 0.1 0.18 11.8 0.1 1.2 1 0 0 1 1 1 0 Threonine/Serine exporter, ThrE Prominin PF05478.9 NM_010756.3_2 - 1.8 6.3 10.8 0.0061 14.5 1.6 1.4 2 0 0 2 2 2 0 Prominin DUF4604 PF15377.4 NM_010756.3_2 - 8.5 6.7 26.5 0.35 11.1 16.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) SHR-BD PF06650.10 NM_001276502.1_3 - 5.8e-84 281.5 0.0 6.2e-83 278.1 0.0 2.7 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13 PF16908.3 NM_001276502.1_3 - 1.7e-55 188.3 2.7 2.2e-53 181.4 1.6 3.2 3 0 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.3 NM_001276502.1_3 - 5.1e-43 147.1 3.3 1.6e-31 109.4 0.0 8.0 6 2 0 6 6 6 3 Repeating coiled region of VPS13 Chorein_N PF12624.5 NM_001276502.1_3 - 1.6e-32 111.9 0.2 6.6e-32 109.9 0.2 2.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.3 NM_001276502.1_3 - 3.9e-23 82.0 7.7 1.1e-20 74.0 0.6 3.7 2 1 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal UBA PF00627.29 NM_001276502.1_3 - 9.5e-05 22.1 0.0 0.00019 21.1 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Apt1 PF10351.7 NM_001276502.1_3 - 0.028 13.2 0.4 0.068 11.9 0.1 1.7 2 0 0 2 2 2 0 Golgi-body localisation protein domain Piwi PF02171.15 NM_001276502.1_3 - 0.11 11.5 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Piwi domain TPR_1 PF00515.26 NM_024499.1_1 - 9.3e-27 91.6 7.0 3.8e-10 39.0 0.3 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat SGTA_dimer PF16546.3 NM_024499.1_1 - 3.8e-20 71.3 0.0 1.2e-19 69.8 0.0 1.9 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_2 PF07719.15 NM_024499.1_1 - 6.5e-19 66.3 7.2 8.2e-07 28.5 0.3 4.3 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_024499.1_1 - 5.4e-18 63.5 3.7 5.9e-08 32.2 0.4 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.4 NM_024499.1_1 - 1.2e-14 53.6 8.5 1.4e-07 31.0 0.7 3.8 2 1 2 4 4 4 3 TPR repeat TPR_17 PF13431.4 NM_024499.1_1 - 9.5e-12 44.3 8.0 7.5e-06 25.8 0.3 4.2 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_024499.1_1 - 4.9e-11 41.7 0.2 0.00025 20.7 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_024499.1_1 - 1.1e-10 41.9 1.3 1e-05 26.0 0.3 2.7 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_024499.1_1 - 5.4e-09 36.0 0.1 0.003 18.1 0.0 3.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_024499.1_1 - 2.5e-07 30.7 4.4 1e-06 28.8 0.6 3.1 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_024499.1_1 - 4.9e-07 30.0 4.3 5e-05 23.6 0.1 3.2 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_10 PF13374.4 NM_024499.1_1 - 1.2e-06 28.1 5.5 0.018 14.8 0.2 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_024499.1_1 - 0.0013 18.7 0.2 0.095 12.7 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_024499.1_1 - 0.004 17.0 0.6 1.5 8.8 0.0 2.8 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TOM20_plant PF06552.10 NM_024499.1_1 - 0.0064 16.1 0.1 0.82 9.2 0.0 2.6 2 0 0 2 2 2 1 Plant specific mitochondrial import receptor subunit TOM20 NARP1 PF12569.6 NM_024499.1_1 - 0.0078 15.0 0.2 1.6 7.4 0.0 2.1 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_6 PF13174.4 NM_024499.1_1 - 0.011 16.2 0.5 0.56 10.8 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.4 NM_024499.1_1 - 0.047 12.8 0.0 0.67 9.0 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.15 NM_024499.1_1 - 0.052 13.8 0.6 1.1 9.6 0.6 2.3 1 1 0 1 1 1 0 Bacterial transcriptional activator domain DUF627 PF04781.10 NM_024499.1_1 - 0.22 11.4 1.0 1.1 9.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF627) XPC-binding PF09280.9 NM_024499.1_1 - 0.76 9.4 7.8 3.1 7.5 3.6 2.7 2 0 0 2 2 2 0 XPC-binding domain MIT PF04212.16 NM_024499.1_1 - 1.7 8.7 7.0 12 6.0 0.0 3.3 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain Takusan PF04822.11 NM_001037919.3_3 - 9.3e-23 79.8 6.0 9.3e-23 79.8 6.0 1.6 2 0 0 2 2 2 1 Takusan DUF342 PF03961.11 NM_001037919.3_3 - 0.39 9.1 6.1 0.5 8.8 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.12 NM_001037919.3_3 - 0.48 10.0 8.2 0.63 9.7 8.2 1.1 1 0 0 1 1 1 0 IncA protein F_actin_cap_B PF01115.15 NM_009798.4_2 - 3.4e-110 367.2 0.0 4.2e-110 366.9 0.0 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit SASA PF03629.16 NM_011734.3_2 - 3.7e-12 46.3 0.0 4e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 Carbohydrate esterase, sialic acid-specific acetylesterase DBD_Tnp_Mut PF03108.13 NM_011734.3_2 - 0.0019 17.8 0.4 1.6 8.5 0.3 2.5 2 0 0 2 2 2 2 MuDR family transposase 7tm_4 PF13853.4 NM_207134.1_1 - 3.9e-51 174.3 23.8 5.1e-51 173.9 23.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207134.1_1 - 3.2e-17 62.5 25.3 6.8e-17 61.5 25.3 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4560 PF15118.4 NM_207134.1_1 - 0.033 14.1 1.9 0.083 12.8 1.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4560) 7TM_GPCR_Srsx PF10320.7 NM_207134.1_1 - 0.31 10.2 25.6 1.5 8.0 25.6 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx ESCRT-II PF05871.10 NM_001284414.1_1 - 4e-52 176.0 0.3 5e-52 175.7 0.3 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit Dynein_heavy PF03028.13 NM_001310335.1_3 - 6.7e-295 979.8 0.1 6.7e-293 973.2 0.0 2.9 3 0 0 3 3 3 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.11 NM_001310335.1_3 - 3.2e-148 494.0 6.3 3.2e-148 494.0 6.3 2.9 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.5 NM_001310335.1_3 - 2.5e-96 320.9 0.1 2.7e-94 314.3 0.3 3.2 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_6 PF12774.5 NM_001310335.1_3 - 1.1e-90 303.3 0.0 3.5e-90 301.7 0.0 1.9 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.5 NM_001310335.1_3 - 2.3e-74 249.8 0.3 3.9e-73 245.8 0.1 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 MT PF12777.5 NM_001310335.1_3 - 3.1e-52 177.6 5.6 3.5e-52 177.4 4.3 1.7 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.5 NM_001310335.1_3 - 7e-51 173.0 0.0 1.3e-50 172.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.12 NM_001310335.1_3 - 1.1e-18 67.5 0.0 0.00054 19.8 0.0 5.9 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA PF00004.27 NM_001310335.1_3 - 1e-05 25.9 1.4 3.2 8.1 0.1 5.6 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 NM_001310335.1_3 - 0.00087 19.4 0.2 5.5 7.1 0.0 4.5 4 0 0 4 4 4 1 AAA domain AAA_16 PF13191.4 NM_001310335.1_3 - 0.0022 18.3 0.0 17 5.6 0.0 3.9 3 0 0 3 3 3 0 AAA ATPase domain AAA_30 PF13604.4 NM_001310335.1_3 - 0.0025 17.4 0.2 3.6 7.1 0.2 2.9 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.20 NM_001310335.1_3 - 0.0058 16.9 0.6 8.7 6.7 0.0 4.3 4 0 0 4 4 4 0 RNA helicase EF-hand_1 PF00036.30 NM_001310335.1_3 - 0.0063 15.8 1.3 0.046 13.1 1.3 2.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.4 NM_001310335.1_3 - 0.019 15.3 3.0 0.033 14.5 0.7 2.8 2 0 0 2 2 1 0 EF-hand domain pair T2SSE PF00437.18 NM_001310335.1_3 - 0.057 12.3 0.9 0.35 9.7 0.0 2.7 4 0 0 4 4 4 0 Type II/IV secretion system protein EF-hand_6 PF13405.4 NM_001310335.1_3 - 0.082 12.8 7.3 0.012 15.3 2.3 2.4 2 0 0 2 2 1 0 EF-hand domain AAA_18 PF13238.4 NM_001310335.1_3 - 0.13 12.6 4.0 0.19 12.1 0.0 3.6 4 0 0 4 4 2 0 AAA domain EF-hand_8 PF13833.4 NM_001310335.1_3 - 0.26 10.9 1.1 2.1 8.1 1.1 2.6 1 0 0 1 1 1 0 EF-hand domain pair MbeD_MobD PF04899.10 NM_001310335.1_3 - 5.4 7.1 6.5 3.1 7.9 0.2 3.9 4 0 0 4 4 4 0 MbeD/MobD like F-box-like PF12937.5 NM_133765.4_1 - 4.3e-12 45.6 1.1 1.4e-11 43.9 1.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_133765.4_1 - 7.8e-10 38.3 2.0 1.6e-09 37.3 2.0 1.5 1 0 0 1 1 1 1 F-box domain DUF3506 PF12014.6 NM_133765.4_1 - 0.0079 16.1 0.1 0.34 10.8 0.2 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF3506) F-box_4 PF15966.3 NM_133765.4_1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 F-box DUF1041 PF06292.15 NM_012061.3_3 - 8.6e-36 122.3 0.9 2.3e-35 120.9 0.9 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) PH PF00169.27 NM_012061.3_3 - 1.9e-08 34.7 0.0 4.8e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 PH domain Sporozoite_P67 PF05642.9 NM_012061.3_3 - 0.077 10.9 9.7 0.16 9.9 9.7 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SMAP PF15477.4 NM_001168218.1_1 - 4.9e-10 40.1 0.4 4.9e-10 40.1 0.4 1.9 2 0 0 2 2 2 1 Small acidic protein family AA_permease_2 PF13520.4 NM_011405.4_2 - 1.4e-61 208.5 42.3 1.8e-61 208.1 42.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 NM_011405.4_2 - 3.2e-25 88.5 35.3 4.6e-25 88.0 35.3 1.2 1 0 0 1 1 1 1 Amino acid permease zf-H2C2_2 PF13465.4 NM_145819.2_1 - 1.6e-75 246.2 73.5 7e-09 35.6 0.2 14.2 14 1 0 14 14 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_145819.2_1 - 1.7e-64 210.7 82.2 1.8e-06 27.9 1.9 13.8 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_145819.2_1 - 2.1e-37 124.4 87.4 0.0023 18.5 1.8 14.0 14 0 0 14 14 13 13 C2H2-type zinc finger SCAN PF02023.15 NM_145819.2_1 - 3.4e-35 119.6 0.6 6.4e-35 118.7 0.6 1.5 1 0 0 1 1 1 1 SCAN domain ADK_lid PF05191.12 NM_145819.2_1 - 7.7e-09 35.3 21.4 0.91 9.5 0.0 8.1 5 2 3 8 8 8 6 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 NM_145819.2_1 - 1.4e-07 31.4 57.0 0.037 14.0 1.9 9.1 4 3 7 11 11 11 8 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_145819.2_1 - 1.1e-06 28.3 65.6 0.29 11.0 0.5 13.0 13 0 0 13 13 13 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_145819.2_1 - 0.00012 22.2 22.3 1.7 8.9 0.0 9.3 11 0 0 11 11 10 1 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_145819.2_1 - 0.01 16.5 33.8 1.9 9.2 2.6 6.9 2 2 5 8 8 8 0 zinc-ribbon family FYDLN_acid PF09538.8 NM_145819.2_1 - 0.013 16.0 23.7 16 6.1 0.1 8.9 2 2 4 7 7 7 0 Protein of unknown function (FYDLN_acid) LIM PF00412.20 NM_145819.2_1 - 0.013 15.5 2.7 0.013 15.5 2.7 8.6 4 2 6 10 10 9 0 LIM domain DUF3268 PF11672.6 NM_145819.2_1 - 0.014 15.6 17.4 5.1 7.3 0.2 5.5 4 1 0 5 5 5 0 zinc-finger-containing domain MBD PF01429.17 NM_145819.2_1 - 0.019 14.5 0.4 8.2 6.1 0.0 3.5 3 1 0 3 3 2 0 Methyl-CpG binding domain HypA PF01155.17 NM_145819.2_1 - 0.023 14.6 36.7 1.3 8.9 0.5 7.1 1 1 6 7 7 7 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HE PF16278.3 NM_145819.2_1 - 0.046 14.1 49.3 0.98 9.8 2.1 10.4 2 2 7 9 9 9 0 C2HE / C2H2 / C2HC zinc-binding finger zf-LYAR PF08790.9 NM_145819.2_1 - 1.6 8.6 41.0 11 5.9 0.2 11.2 13 0 0 13 13 13 0 LYAR-type C2HC zinc finger CpXC PF14353.4 NM_145819.2_1 - 4.9 7.1 35.8 6.9 6.6 0.1 9.0 3 3 6 10 10 10 0 CpXC protein KH_1 PF00013.27 NM_001301344.1_1 - 1.5e-42 143.1 13.9 9.9e-20 70.0 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 NM_001301344.1_1 - 6.6e-27 93.4 8.3 4.7e-26 90.6 9.8 1.7 2 0 0 2 2 2 1 ROKNT (NUC014) domain KH_2 PF07650.15 NM_001301344.1_1 - 1.1e-11 44.2 11.5 0.0014 18.3 0.5 3.6 2 1 2 4 4 4 3 KH domain KH_4 PF13083.4 NM_001301344.1_1 - 7.5e-08 32.0 5.9 1.2e-05 25.0 0.0 3.2 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 NM_001301344.1_1 - 0.00017 21.5 3.0 0.54 10.3 0.1 3.5 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.3 NM_001301344.1_1 - 0.09 12.7 0.0 2.8 7.9 0.0 2.3 2 0 0 2 2 2 0 KH-like RNA-binding domain DJ-1_PfpI PF01965.22 NM_001301344.1_1 - 0.14 11.8 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 DJ-1/PfpI family SET PF00856.26 NM_138679.5_2 - 1e-21 77.9 0.2 6.1e-21 75.4 0.2 2.6 1 0 0 1 1 1 1 SET domain BAH PF01426.16 NM_138679.5_2 - 5.9e-20 71.2 0.1 1.5e-19 69.9 0.1 1.8 1 0 0 1 1 1 1 BAH domain Bromodomain PF00439.23 NM_138679.5_2 - 3.8e-16 58.8 0.0 1e-15 57.5 0.0 1.7 1 0 0 1 1 1 1 Bromodomain PHD PF00628.27 NM_138679.5_2 - 2.9e-06 26.9 13.4 2.9e-06 26.9 13.4 2.7 2 0 0 2 2 2 1 PHD-finger RnaseA PF00074.18 NM_001011875.2_2 - 1.2e-24 87.0 1.9 1.5e-24 86.7 1.9 1.1 1 0 0 1 1 1 1 Pancreatic ribonuclease Jiv90 PF14901.4 NM_001011875.2_2 - 0.023 14.7 0.2 0.036 14.2 0.2 1.2 1 0 0 1 1 1 0 Cleavage inducing molecular chaperone WD40_alt PF14077.4 NM_175450.4_3 - 2.3e-22 78.4 0.0 4e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Alternative WD40 repeat motif WD40 PF00400.30 NM_175450.4_3 - 9.7e-16 57.8 11.3 3.4e-08 33.9 0.4 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_175450.4_3 - 0.00013 22.0 0.1 0.0032 17.6 0.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_175450.4_3 - 0.0094 14.5 1.0 0.04 12.4 0.2 1.9 1 1 0 2 2 2 1 Nucleoporin Nup120/160 Defensin_beta PF00711.17 NM_139221.2_3 - 2.5e-11 43.2 9.8 2.5e-11 43.2 9.8 1.8 2 0 0 2 2 2 1 Beta defensin PP2C PF00481.19 NM_175523.4_1 - 1.3e-55 188.8 0.0 1.7e-55 188.3 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.4 NM_175523.4_1 - 7.8e-08 32.1 0.0 1.6e-07 31.0 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C CD225 PF04505.10 NM_177265.4_3 - 1.5e-07 31.3 0.1 4.5e-07 29.8 0.1 1.8 1 0 0 1 1 1 1 Interferon-induced transmembrane protein HA2 PF04408.21 NM_133941.2_3 - 6.5e-20 71.3 0.0 1.2e-19 70.4 0.0 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.14 NM_133941.2_3 - 7e-14 51.8 0.0 1.4e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold RasGEF PF00617.17 NM_175258.4_2 - 1.7e-51 174.6 0.2 3.3e-51 173.7 0.2 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 NM_175258.4_2 - 1.3e-12 47.7 0.7 2.4e-11 43.7 0.7 2.6 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 NM_175258.4_2 - 3.4e-12 46.7 0.0 8.7e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ PF00595.22 NM_175258.4_2 - 9.4e-12 45.0 0.0 2.5e-11 43.7 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) cNMP_binding PF00027.27 NM_175258.4_2 - 1.7e-11 43.9 0.0 7.3e-08 32.2 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_2 PF13180.4 NM_175258.4_2 - 0.00017 21.7 0.0 0.00044 20.4 0.0 1.6 1 0 0 1 1 1 1 PDZ domain 3Beta_HSD PF01073.17 NM_010941.3_3 - 9.9e-62 208.3 0.0 1.3e-61 207.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 NM_010941.3_3 - 6.5e-34 117.3 0.0 8.8e-34 116.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 NM_010941.3_3 - 8.9e-18 64.6 0.0 2.4e-16 59.9 0.0 2.3 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 NM_010941.3_3 - 6.1e-14 52.2 0.0 8.8e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 NM_010941.3_3 - 5.4e-10 38.7 0.0 8.1e-10 38.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.10 NM_010941.3_3 - 2.6e-08 33.2 0.0 0.00081 18.5 0.0 2.4 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.13 NM_010941.3_3 - 3.2e-07 29.6 0.0 1.7e-06 27.2 0.0 2.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.11 NM_010941.3_3 - 0.00059 19.3 0.0 0.00095 18.7 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_2 PF03446.13 NM_010941.3_3 - 0.029 14.4 0.0 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Drf_FH1 PF06346.10 NM_001286015.1_1 - 0.0014 18.2 9.8 0.0026 17.3 9.8 1.3 1 0 0 1 1 1 1 Formin Homology Region 1 Casein PF00363.16 NM_001286015.1_2 - 5.6e-21 74.9 12.8 5.6e-21 74.9 12.8 3.8 2 1 1 3 3 3 1 Casein NupH_GANP PF16768.3 NM_001286015.1_2 - 0.0065 16.1 10.4 0.029 13.9 9.6 2.2 2 0 0 2 2 2 1 Nucleoporin homology of Germinal-centre associated nuclear protein Dimeth_Pyl PF09505.8 NM_001286015.1_2 - 0.25 9.7 0.1 0.47 8.8 0.0 1.4 2 0 0 2 2 2 0 Dimethylamine methyltransferase (Dimeth_PyL) FAM110_C PF14160.4 NM_001286015.1_2 - 0.63 11.0 5.7 0.35 11.8 3.3 1.8 2 0 0 2 2 2 0 Centrosome-associated C terminus TRAM_LAG1_CLN8 PF03798.14 NM_146140.3_2 - 1e-19 71.0 9.9 2.5e-19 69.7 9.9 1.7 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.9 NM_146140.3_2 - 4.7e-18 64.5 0.1 1.4e-17 63.0 0.1 1.9 2 0 0 2 2 2 1 TRAM1-like protein Tom37 PF10568.7 NM_001161824.1_2 - 2.1e-44 150.8 0.0 3.5e-44 150.1 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.2 NM_001161824.1_2 - 6.6e-21 73.7 0.5 1.1e-20 73.0 0.5 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.2 NM_001161824.1_2 - 4.2e-19 69.0 0.0 1.4e-18 67.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.4 NM_001161824.1_2 - 2e-06 27.5 0.0 4.6e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 NM_001161824.1_2 - 0.0031 17.6 0.0 0.0058 16.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain CAF1 PF04857.18 NM_028761.3_1 - 9.5e-87 291.0 2.5 1.6e-86 290.3 2.5 1.3 1 0 0 1 1 1 1 CAF1 family ribonuclease RNA_bind PF08675.9 NM_028761.3_1 - 1.7e-33 114.3 0.1 3.3e-33 113.4 0.1 1.5 1 0 0 1 1 1 1 RNA binding domain R3H PF01424.20 NM_028761.3_1 - 5.2e-07 29.4 0.0 1.2e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 R3H domain NCBP3 PF10309.7 NM_028761.3_1 - 0.016 14.9 0.1 0.037 13.8 0.1 1.6 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 RRM_1 PF00076.20 NM_028761.3_1 - 0.037 13.7 0.0 0.083 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) V1R PF03402.12 NM_001166750.1_1 - 4.9e-15 55.7 10.5 6.5e-15 55.3 10.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001166750.1_1 - 3.4e-14 52.5 13.4 4.2e-14 52.2 13.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001166750.1_1 - 4.1e-06 26.1 13.1 5.5e-06 25.7 13.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1700 PF08006.9 NM_001166750.1_1 - 0.089 12.2 3.2 0.14 11.6 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) EF-hand_1 PF00036.30 NM_012038.4_2 - 8.4e-23 78.1 11.1 4.4e-07 28.9 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 NM_012038.4_2 - 8.4e-23 80.5 5.8 2.5e-15 56.6 0.7 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.4 NM_012038.4_2 - 4.2e-20 69.8 5.3 1.5e-06 27.6 0.1 4.5 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.4 NM_012038.4_2 - 1.9e-14 52.3 9.8 3e-05 23.2 0.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 NM_012038.4_2 - 1.6e-10 40.5 9.7 8.2e-05 22.2 2.1 3.8 2 2 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_012038.4_2 - 0.0014 18.8 1.8 0.46 10.7 0.5 3.2 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.11 NM_012038.4_2 - 0.023 14.5 3.0 1 9.1 3.0 3.1 1 1 0 1 1 1 0 Caleosin related protein p25-alpha PF05517.10 NM_012038.4_2 - 0.031 14.3 0.9 0.22 11.5 0.2 2.1 2 0 0 2 2 2 0 p25-alpha IL3 PF02059.13 NM_012038.4_2 - 0.064 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Interleukin-3 EF-hand_4 PF12763.5 NM_012038.4_2 - 3.9 7.4 6.3 41 4.1 0.0 3.6 2 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand DUF1049 PF06305.9 NM_001291167.1_1 - 0.12 12.1 1.2 0.26 11.0 1.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) PID PF00640.21 NM_001291167.1_3 - 1.7e-51 173.8 2.3 3e-51 173.0 2.3 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.22 NM_001291167.1_3 - 9.4e-28 96.3 5.8 4.3e-13 49.3 0.4 2.7 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001291167.1_3 - 1.9e-05 24.7 0.1 0.0022 18.1 0.0 2.5 2 0 0 2 2 2 1 PDZ domain NRho PF16733.3 NM_001291167.1_3 - 0.096 12.6 0.3 0.29 11.1 0.1 1.8 2 0 0 2 2 2 0 Rhomboid N-terminal domain DUF3915 PF13054.4 NM_001291167.1_3 - 0.099 12.5 0.4 0.37 10.6 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) OAD_gamma PF04277.11 NM_001291167.1_3 - 0.47 10.9 1.7 0.93 10.0 0.1 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain U3_snoRNA_assoc PF08297.9 NM_001291167.1_3 - 1 10.0 9.8 0.24 12.0 3.8 2.7 2 0 0 2 2 2 0 U3 snoRNA associated IL8 PF00048.18 NM_001048179.1_3 - 3.4e-07 30.2 0.1 6.7e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like HMG_box_2 PF09011.8 NM_001293624.1_2 - 4.4e-48 161.6 10.2 1.6e-29 102.2 7.2 2.4 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.17 NM_001293624.1_2 - 1.5e-44 150.1 9.6 3.4e-27 94.5 0.1 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_5 PF14887.4 NM_001293624.1_2 - 0.00037 20.3 9.1 0.033 14.0 0.4 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box 5 Ribosomal_60s PF00428.17 NM_001293624.1_2 - 0.97 9.9 18.3 2 8.9 18.3 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein WD40 PF00400.30 NM_001081402.1_1 - 3.5e-19 68.6 11.4 0.002 18.8 0.2 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001081402.1_1 - 1e-08 35.2 0.1 1.1 9.5 0.0 5.4 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 NM_001081402.1_1 - 0.0027 16.6 0.1 0.43 9.3 0.1 3.2 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein AF-4 PF05110.11 NM_001081402.1_1 - 3.9 5.3 14.0 6.7 4.5 14.0 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Mito_carr PF00153.25 NM_001289595.1_2 - 1.8e-61 204.0 0.4 2.7e-21 75.1 0.0 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein S-antigen PF05756.9 NM_001289595.1_2 - 3.5 7.8 4.9 0.36 11.0 0.2 1.7 2 0 0 2 2 2 0 S-antigen protein AlbA_2 PF04326.12 NM_177570.3_2 - 2.3e-27 95.6 0.0 3.9e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Putative DNA-binding domain bZIP_1 PF00170.19 NM_177570.3_2 - 0.032 14.2 1.7 0.077 13.0 1.7 1.6 1 0 0 1 1 1 0 bZIP transcription factor NST1 PF13945.4 NM_177570.3_2 - 5.8 6.8 6.1 9.3 6.2 6.1 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator 7tm_4 PF13853.4 NM_001011790.1_1 - 4.6e-48 164.2 15.1 6.1e-48 163.8 15.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011790.1_1 - 4.2e-21 75.2 16.2 8e-21 74.3 16.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011790.1_1 - 0.00011 21.6 11.6 0.00011 21.6 11.6 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 NM_001011790.1_1 - 0.00076 18.8 13.6 0.0013 18.0 13.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srbc PF10316.7 NM_001011790.1_1 - 0.0015 18.0 6.6 0.003 17.0 6.6 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc Interferon PF00143.17 NM_177348.2_2 - 1.6e-49 168.1 1.4 1.8e-49 167.8 1.4 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain EBV-NA3 PF05009.10 NM_177348.2_2 - 0.25 10.7 1.2 0.59 9.5 0.5 1.7 1 1 1 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) DUF3736 PF12540.6 NM_198671.2_1 - 3.4e-57 192.2 17.3 6.9e-43 145.9 7.7 5.5 6 0 0 6 6 6 2 Protein of unknown function (DUF3736) FOXP-CC PF16159.3 NM_198671.2_1 - 4.2 7.9 6.8 4 8.0 4.1 2.6 2 0 0 2 2 2 0 FOXP coiled-coil domain DENN PF02141.19 NM_001001326.1_2 - 1.4e-57 194.5 0.5 1.4e-57 194.5 0.5 1.9 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.16 NM_001001326.1_2 - 2.6e-17 63.3 0.1 7.8e-17 61.7 0.1 1.9 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 NM_001001326.1_2 - 2.8e-12 46.3 4.7 3.9e-12 45.8 3.2 2.2 2 0 0 2 2 2 1 dDENN domain CHCH PF06747.11 NM_197980.1_2 - 1.2e-05 25.2 8.7 2.1e-05 24.4 8.7 1.5 1 0 0 1 1 1 1 CHCH domain NDUF_B7 PF05676.11 NM_197980.1_2 - 0.012 15.2 1.4 0.022 14.3 1.4 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.8 NM_197980.1_2 - 0.013 15.3 2.8 0.029 14.3 2.8 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Bax1-I PF01027.18 NM_028224.4_2 - 1.6e-31 109.7 31.2 2.5e-31 109.0 31.2 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 CMV_US PF08001.9 NM_028224.4_2 - 0.041 13.0 0.4 0.07 12.3 0.4 1.2 1 0 0 1 1 1 0 CMV US SAM_1 PF00536.28 NM_001177398.1_2 - 5.4e-35 119.5 0.5 4.4e-16 59.0 0.0 3.0 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001177398.1_2 - 1.3e-27 95.6 0.5 4e-15 55.5 0.1 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.21 NM_001177398.1_2 - 4e-20 72.1 0.8 6.3e-20 71.5 0.8 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 NM_001177398.1_2 - 0.00064 19.7 0.0 0.0011 19.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Coq4 PF05019.11 NM_001177398.1_2 - 0.0038 16.4 0.0 0.0081 15.4 0.0 1.4 1 1 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 PID_2 PF14719.4 NM_001177398.1_2 - 0.01 15.6 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) NACHT PF05729.10 NM_001002894.2_2 - 1e-36 126.3 0.5 2.8e-36 124.8 0.2 2.0 2 0 0 2 2 2 1 NACHT domain LRR_6 PF13516.4 NM_001002894.2_2 - 3.7e-17 60.7 40.5 0.0019 18.0 1.6 10.8 10 0 0 10 10 10 5 Leucine Rich repeat AAA_16 PF13191.4 NM_001002894.2_2 - 0.0003 21.1 0.1 0.003 17.8 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.20 NM_001002894.2_2 - 0.009 14.9 0.2 0.026 13.5 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain AAA_14 PF13173.4 NM_001002894.2_2 - 0.0097 15.8 0.0 0.036 14.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.16 NM_001002894.2_2 - 0.018 14.8 0.0 0.06 13.1 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA PF00004.27 NM_001002894.2_2 - 0.037 14.3 0.0 0.15 12.4 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.4 NM_001002894.2_2 - 0.039 13.5 0.0 0.071 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.4 NM_001002894.2_2 - 0.042 14.0 0.1 0.59 10.3 0.1 2.8 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.7 NM_001002894.2_2 - 0.092 11.8 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF258 PF03193.14 NM_001002894.2_2 - 0.11 12.2 0.0 0.36 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Syntaxin-18_N PF10496.7 NM_026959.3_1 - 9e-21 73.8 0.5 3.3e-20 72.0 0.0 2.1 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Phage_Integr_2 PF13009.4 NM_026959.3_1 - 0.17 10.9 0.7 0.25 10.3 0.7 1.2 1 0 0 1 1 1 0 Putative phage integrase CHASE3 PF05227.11 NM_026959.3_1 - 0.72 9.6 2.8 1.5 8.6 0.1 2.1 2 0 0 2 2 2 0 CHASE3 domain TMEM51 PF15345.4 NM_145402.3_3 - 5e-86 288.3 0.1 6.3e-86 287.9 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 TMEM61 PF15105.4 NM_145402.3_3 - 3.2e-05 23.7 0.1 0.00022 21.0 0.0 2.1 1 1 1 2 2 2 1 TMEM61 protein family WBP-1 PF11669.6 NM_145402.3_3 - 0.0054 17.2 1.4 0.026 15.0 0.0 2.5 3 0 0 3 3 3 1 WW domain-binding protein 1 RCR PF12273.6 NM_145402.3_3 - 0.0057 17.2 1.3 0.0057 17.2 1.3 2.1 2 1 0 2 2 2 1 Chitin synthesis regulation, resistance to Congo red FAM176 PF14851.4 NM_145402.3_3 - 0.0066 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 FAM176 family V-set PF07686.15 NM_001076679.2_3 - 1.9e-16 60.0 0.6 3.8e-16 59.1 0.2 1.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 NM_001076679.2_3 - 3.4e-07 30.2 0.0 9.4e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_001076679.2_3 - 3.6e-07 30.6 0.2 9.3e-07 29.2 0.1 1.7 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 NM_001076679.2_3 - 1.5e-05 24.8 0.0 3e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001076679.2_3 - 0.00027 21.1 0.1 0.00086 19.5 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Yae1_N PF09811.7 NM_015812.4_2 - 5 6.8 14.8 1.9e+02 1.7 14.8 2.5 1 1 0 1 1 1 0 Essential protein Yae1, N terminal RGS PF00615.17 NM_015812.4_3 - 1.8e-33 115.2 0.5 4.4e-33 113.9 0.5 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.19 NM_015812.4_3 - 5.7e-17 61.4 0.0 1.2e-16 60.4 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.20 NM_015812.4_3 - 2.1e-11 43.5 0.0 4.3e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 GGL domain Yae1_N PF09811.7 NM_015812.4_3 - 5.4 6.7 10.6 11 5.7 10.6 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Claudin_2 PF13903.4 NM_171826.3_2 - 2.2e-21 76.4 0.8 3.5e-21 75.7 0.8 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 NM_171826.3_2 - 1.1e-10 41.5 3.5 1.9e-08 34.2 3.5 2.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family IL4Ra_N PF09238.8 NM_001008700.3_2 - 1.9e-35 120.9 2.8 3.9e-35 120.0 2.8 1.6 1 0 0 1 1 1 1 Interleukin-4 receptor alpha chain, N-terminal Proteasome PF00227.24 NM_001289476.1_2 - 6.2e-60 201.8 0.1 8.7e-60 201.3 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 NM_001289476.1_2 - 2.6e-14 52.4 0.2 7.5e-14 50.9 0.2 1.9 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature 7tm_1 PF00001.19 NM_001271607.1_1 - 1.3e-44 152.4 30.7 4.9e-44 150.5 30.7 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pep_M12B_propep PF01562.17 NM_177872.2_1 - 1.4e-39 135.4 0.0 2.5e-39 134.6 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.12 NM_177872.2_1 - 2.1e-25 88.9 0.0 3.4e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.17 NM_177872.2_1 - 1.2e-18 67.6 0.0 2.1e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease TSP_1 PF00090.17 NM_177872.2_1 - 2.8e-17 62.5 64.8 1.3e-08 34.8 6.9 6.3 5 0 0 5 5 5 4 Thrombospondin type 1 domain Reprolysin_5 PF13688.4 NM_177872.2_1 - 6.3e-13 49.2 1.2 1.4e-12 48.1 1.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.4 NM_177872.2_1 - 6.1e-09 35.9 0.4 1.1e-08 35.1 0.4 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.4 NM_177872.2_1 - 8.5e-09 35.9 0.3 1.8e-08 34.8 0.3 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_177872.2_1 - 1e-05 25.2 0.2 2e-05 24.2 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 NM_177872.2_1 - 0.0045 16.7 0.1 0.01 15.6 0.1 1.5 1 0 0 1 1 1 1 Matrixin PLAC PF08686.9 NM_177872.2_1 - 0.0064 17.1 7.6 0.0064 17.1 7.6 3.0 2 0 0 2 2 1 1 PLAC (protease and lacunin) domain DUF4953 PF16313.3 NM_177872.2_1 - 0.25 10.4 0.4 0.42 9.6 0.4 1.2 1 0 0 1 1 1 0 Met-zincin Pkinase PF00069.23 NM_001324552.1_1 - 2.3e-70 236.9 0.0 2.8e-70 236.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001324552.1_1 - 2.2e-43 148.3 0.0 2.9e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001324552.1_1 - 5e-06 25.9 0.1 1.9e-05 24.0 0.0 1.9 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.20 NM_001324552.1_1 - 0.00033 20.2 0.1 0.0006 19.3 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 NM_001324552.1_1 - 0.002 17.4 0.1 0.0034 16.6 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.7 NM_001324552.1_1 - 0.02 14.3 0.4 0.07 12.5 0.1 1.8 1 1 1 2 2 2 0 PhoP regulatory network protein YrbL DUF3776 PF12618.6 NM_172674.2_1 - 2.1e-26 92.1 16.6 2.1e-26 92.1 16.6 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF3776) PHD PF00628.27 NM_172674.2_1 - 4e-06 26.5 13.6 4e-06 26.5 13.6 2.1 2 0 0 2 2 2 1 PHD-finger MBT PF02820.16 NM_172674.2_1 - 0.00015 21.9 0.6 0.00079 19.6 0.1 2.3 2 0 0 2 2 2 1 mbt repeat DUF1325 PF07039.9 NM_172674.2_1 - 0.00032 20.7 0.0 0.00093 19.2 0.0 1.7 1 0 0 1 1 1 1 SGF29 tudor-like domain DUF4537 PF15057.4 NM_172674.2_1 - 0.0019 18.1 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Tudor-knot PF11717.6 NM_172674.2_1 - 0.032 14.0 1.4 0.1 12.4 1.4 1.9 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Rad9_Rad53_bind PF08605.8 NM_172674.2_1 - 0.082 12.8 0.1 1.3 8.9 0.1 2.2 2 0 0 2 2 2 0 Fungal Rad9-like Rad53-binding LBR_tudor PF09465.8 NM_172674.2_1 - 0.15 11.7 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Perm-CXXC PF15629.4 NM_001305143.1_2 - 0.068 13.3 3.7 2.3 8.5 0.4 2.8 2 0 0 2 2 2 0 Permuted single zf-CXXC unit DUF3488 PF11992.6 NM_001305143.1_2 - 1 8.1 9.9 1.4 7.6 9.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) Ig_3 PF13927.4 NM_001310545.1_1 - 1.6e-15 57.3 0.0 2.2e-07 31.3 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_001310545.1_1 - 6.2e-15 55.2 0.0 8.5e-09 35.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001310545.1_1 - 4.5e-08 33.0 0.0 0.001 19.0 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_001310545.1_1 - 0.0016 18.3 0.0 0.17 11.8 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin I-set domain V-set PF07686.15 NM_001310545.1_1 - 0.0067 16.4 0.1 1.7 8.7 0.0 3.5 3 1 1 4 4 4 1 Immunoglobulin V-set domain SH3BGR PF04908.13 NM_015825.2_1 - 3.3e-46 155.4 0.0 5.5e-46 154.6 0.0 1.4 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.22 NM_015825.2_1 - 0.00028 20.9 0.3 0.00069 19.6 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin NPR3 PF03666.11 NM_015825.2_2 - 8.8 4.9 12.7 12 4.4 12.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ins145_P3_rec PF08709.9 NM_080553.3_1 - 7.4e-97 322.6 0.1 4e-96 320.2 0.3 2.1 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RYDR_ITPR PF01365.19 NM_080553.3_1 - 1.7e-72 243.0 16.9 5.4e-63 212.0 1.5 3.8 4 0 0 4 4 4 2 RIH domain MIR PF02815.17 NM_080553.3_1 - 3.5e-68 229.0 0.1 1.8e-62 210.4 0.0 2.7 2 0 0 2 2 2 2 MIR domain RIH_assoc PF08454.9 NM_080553.3_1 - 1.1e-31 108.6 4.7 1.1e-31 108.6 4.7 6.2 7 1 0 7 7 7 2 RyR and IP3R Homology associated Ion_trans PF00520.29 NM_080553.3_1 - 3.6e-17 62.3 11.4 8e-17 61.2 11.4 1.6 1 0 0 1 1 1 1 Ion transport protein Serum_albumin PF00273.18 NM_009654.4_3 - 1.9e-157 519.4 50.5 5.1e-57 192.3 12.8 3.1 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 NM_009654.4_3 - 1.2e-06 28.3 24.8 0.024 14.5 0.4 7.0 7 0 0 7 7 7 5 Vitamin D binding protein, domain III DUF4144 PF13642.4 NM_009654.4_3 - 0.093 13.2 3.1 4.1 7.9 0.2 3.5 3 0 0 3 3 3 0 protein structure with unknown function DUF1180 PF06679.10 NM_026280.3_1 - 0.53 10.5 3.5 0.95 9.7 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) PseudoU_synth_2 PF00849.20 NM_028040.2_1 - 4.2e-34 117.9 0.0 6.9e-34 117.1 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase TPR_1 PF00515.26 NM_178112.5_3 - 0.0038 16.8 1.1 1.7 8.5 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_178112.5_3 - 0.0049 16.8 3.4 2.7 8.2 0.2 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat Cas_Csx8 PF09657.8 NM_178112.5_3 - 0.017 14.0 0.8 0.56 9.0 0.1 2.5 2 0 0 2 2 2 0 CRISPR-associated protein Csx8 (Cas_Csx8) TPR_11 PF13414.4 NM_178112.5_3 - 0.039 13.5 0.3 9.5 5.9 0.0 2.8 2 0 0 2 2 2 0 TPR repeat TPR_8 PF13181.4 NM_178112.5_3 - 0.043 13.9 1.7 11 6.4 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PRP21_like_P PF12230.6 NM_175028.1_2 - 0.00089 19.0 1.2 0.69 9.6 0.0 2.8 1 1 2 3 3 3 2 Pre-mRNA splicing factor PRP21 like protein Homeobox PF00046.27 NM_175028.1_2 - 0.0038 16.9 0.1 0.0083 15.8 0.1 1.5 1 0 0 1 1 1 1 Homeobox domain zf-Di19 PF05605.10 NM_175028.1_2 - 0.0042 17.2 4.5 0.0042 17.2 4.5 6.5 6 2 1 7 7 7 3 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.4 NM_175028.1_2 - 0.031 14.0 3.2 14 5.6 0.0 4.8 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.4 NM_175028.1_2 - 0.076 13.8 69.1 5.3 8.0 0.1 11.5 11 0 0 11 11 11 0 C2H2-type zinc finger DUF4674 PF15719.3 NM_175028.1_2 - 0.17 11.7 12.6 1.1 9.1 0.1 4.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4674) zf-C2H2_2 PF12756.5 NM_175028.1_2 - 6.1 7.1 41.3 1.2 9.4 0.2 7.6 4 2 3 7 7 7 0 C2H2 type zinc-finger (2 copies) zf-CCHC PF00098.21 NM_145453.2_3 - 3.1e-11 42.7 34.5 1.3e-05 24.9 0.5 4.7 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_2 PF13696.4 NM_145453.2_3 - 0.00032 20.3 19.7 0.42 10.3 0.3 4.3 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.4 NM_145453.2_3 - 0.37 10.4 24.1 0.055 13.0 0.8 4.5 4 0 0 4 4 4 0 Zinc knuckle PKI PF02827.14 NM_001164053.1_2 - 3.3e-28 97.6 0.4 5.5e-28 96.8 0.4 1.4 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor 7tm_4 PF13853.4 NM_147060.2_1 - 1.4e-101 339.8 23.2 1.7e-101 339.5 23.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147060.2_1 - 1.9e-19 69.8 26.1 3.6e-19 68.9 26.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147060.2_1 - 2e-08 33.8 24.2 8.8e-08 31.7 24.2 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1704 PF08014.9 NM_026739.1_2 - 5.3e-15 55.2 0.0 9.9e-14 51.0 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1704) LCE PF14672.4 NM_026335.2_3 - 4.7e-08 33.4 146.8 9.5e-07 29.2 61.5 6.2 2 1 2 4 4 4 2 Late cornified envelope LMWPc PF01451.19 NM_021330.4_3 - 9.2e-49 165.3 0.1 1.3e-48 164.9 0.1 1.2 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Mab-21 PF03281.12 NM_001001738.2_2 - 1.8e-15 56.9 0.1 3.3e-15 56.1 0.1 1.4 1 1 0 1 1 1 1 Mab-21 protein Peptidase_M20 PF01546.26 NM_025371.3_3 - 4.2e-37 127.7 0.0 5.3e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 NM_025371.3_3 - 8.1e-14 51.3 0.0 1.3e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.15 NM_025371.3_3 - 6.7e-06 25.8 0.0 0.00018 21.1 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M28 GRIP PF01465.18 NM_025371.3_3 - 0.035 13.9 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 GRIP domain Peptidase_S68 PF10461.7 NM_022654.1_1 - 7e-21 74.0 10.9 5e-18 64.9 0.7 3.2 3 0 0 3 3 3 2 Peptidase S68 LRR_8 PF13855.4 NM_022654.1_1 - 1.2e-20 72.9 26.3 4.1e-09 36.0 7.6 4.2 2 2 2 4 4 4 4 Leucine rich repeat ZU5 PF00791.18 NM_022654.1_1 - 1.5e-15 57.2 2.7 2.9e-07 30.6 0.0 2.4 2 0 0 2 2 2 2 ZU5 domain LRR_4 PF12799.5 NM_022654.1_1 - 6.2e-15 54.9 26.5 0.00048 20.3 4.3 5.9 3 2 0 5 5 5 4 Leucine Rich repeats (2 copies) Death PF00531.20 NM_022654.1_1 - 1.4e-14 53.8 0.0 4.2e-14 52.3 0.0 1.8 1 0 0 1 1 1 1 Death domain LRR_1 PF00560.31 NM_022654.1_1 - 2.1 9.0 20.9 34 5.3 0.2 7.1 6 1 0 6 6 6 0 Leucine Rich Repeat Insulin PF00049.16 NM_011272.2_3 - 8.9e-17 61.7 0.4 1.4e-16 61.2 0.4 1.3 1 0 0 1 1 1 1 Insulin/IGF/Relaxin family Calpain_inhib PF00748.17 NM_011272.2_3 - 0.053 13.9 0.3 0.071 13.4 0.3 1.2 1 0 0 1 1 1 0 Calpain inhibitor Ins_beta PF03488.12 NM_011272.2_3 - 0.49 10.3 4.8 3.1 7.8 0.6 2.4 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type 3Beta_HSD PF01073.17 NM_001270429.1_1 - 4.6e-105 350.5 0.0 5.9e-105 350.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 NM_001270429.1_1 - 9.3e-23 80.8 0.0 1.2e-22 80.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 NM_001270429.1_1 - 2.5e-16 59.5 0.5 5.8e-16 58.3 0.5 1.5 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.4 NM_001270429.1_1 - 7.7e-13 48.6 0.0 1.1e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.3 NM_001270429.1_1 - 1.1e-11 44.6 0.3 6.9e-11 42.0 0.1 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.11 NM_001270429.1_1 - 9.5e-11 41.6 0.0 1.3e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.13 NM_001270429.1_1 - 1.3e-10 40.7 0.0 2.8e-10 39.7 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.15 NM_001270429.1_1 - 5.1e-07 28.9 0.0 6.9e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 NM_001270429.1_1 - 1.3e-06 28.3 0.1 2.4e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 KR domain Ldh_1_N PF00056.21 NM_001270429.1_1 - 0.047 13.6 0.7 0.082 12.9 0.0 1.6 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.22 NM_001270429.1_1 - 0.14 12.5 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain TPD52 PF04201.13 NM_001291200.1_2 - 1e-66 223.4 5.5 2.9e-34 117.9 1.1 2.2 1 1 1 2 2 2 2 Tumour protein D52 family Glyco_hydro_36 PF17167.2 NM_001291200.1_2 - 0.2 10.2 0.0 0.28 9.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain IMUP PF15761.3 NM_001039586.1_1 - 0.19 12.3 4.6 0.36 11.4 4.6 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF4147 PF13660.4 NM_001039586.1_3 - 3.7e-83 278.4 1.2 5.7e-83 277.8 1.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.11 NM_001039586.1_3 - 9.4e-35 119.0 0.2 1.7e-34 118.2 0.2 1.4 1 0 0 1 1 1 1 MOFRL family Ribosomal_L7Ae PF01248.24 NM_001163485.1_2 - 9.9e-26 89.2 0.1 1.3e-25 88.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.4 NM_001163485.1_2 - 0.08 12.9 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Fibrinogen_C PF00147.16 NM_007426.4_3 - 4.7e-69 232.4 6.3 6.7e-69 231.9 6.3 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain UCH PF00443.27 NM_007426.4_3 - 0.0092 15.4 0.1 0.013 14.9 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SlyX PF04102.10 NM_007426.4_3 - 0.41 11.2 19.7 0.33 11.5 6.7 2.9 1 1 2 3 3 3 0 SlyX DUF4239 PF14023.4 NM_007426.4_3 - 1 8.9 6.0 2 8.0 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) zf-C2H2_4 PF13894.4 NM_001004061.1_1 - 0.013 16.1 5.1 0.31 11.8 0.8 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger IL13 PF03487.11 NM_008355.3_3 - 7.4e-55 184.2 0.0 9.8e-55 183.8 0.0 1.2 1 0 0 1 1 1 1 Interleukin-13 ORMDL PF04061.12 NM_025661.4_3 - 1.5e-52 176.8 4.8 2e-52 176.5 4.8 1.1 1 0 0 1 1 1 1 ORMDL family DUF4347 PF14252.4 NM_001039386.1_1 - 0.00058 19.6 0.0 0.00097 18.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) DUF1011 PF06237.10 NM_001164819.1_2 - 2.7e-39 133.3 7.4 2.7e-39 133.3 7.4 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1011) HEAT_2 PF13646.4 NM_178632.6_1 - 0.00037 20.7 1.4 0.21 11.9 0.1 4.4 4 0 0 4 4 4 1 HEAT repeats TPR_6 PF13174.4 NM_178632.6_1 - 0.0028 18.1 1.6 3.9 8.2 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF3453 PF11935.6 NM_178632.6_1 - 0.45 10.0 4.9 0.94 8.9 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3453) Yae1_N PF09811.7 NM_001310710.1_1 - 9.2 5.9 12.6 87 2.8 12.6 2.1 1 1 0 1 1 1 0 Essential protein Yae1, N terminal MFS_1 PF07690.14 NM_001310710.1_2 - 1.9e-32 112.5 30.6 3.7e-32 111.5 28.7 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Yae1_N PF09811.7 NM_001310710.1_2 - 2.5 7.8 15.4 31 4.3 15.4 2.2 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Yae1_N PF09811.7 NM_001310710.1_3 - 6.5 6.4 16.9 1.8e+02 1.8 16.9 2.3 1 1 0 1 1 1 0 Essential protein Yae1, N terminal DUF3585 PF12130.6 NM_144518.3_2 - 3.7e-18 65.8 15.1 5.3e-18 65.3 15.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) DM PF00751.16 NM_145831.3_1 - 3.7e-21 74.6 12.9 3.7e-21 74.6 12.9 2.4 3 0 0 3 3 3 1 DM DNA binding domain TruB_N PF01509.16 NM_001290496.1_1 - 2.5e-12 47.3 0.1 4.3e-12 46.5 0.1 1.2 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) DUF1161 PF06649.10 NM_001290496.1_1 - 0.0021 18.0 9.3 1.2 9.2 0.2 3.7 1 1 3 4 4 4 3 Protein of unknown function (DUF1161) PseudoU_synth_2 PF00849.20 NM_001290496.1_1 - 0.069 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 RNA pseudouridylate synthase HlyD_2 PF12700.5 NM_001290496.1_1 - 2.7 7.3 6.1 7.5 5.8 0.7 2.7 1 1 2 3 3 3 0 HlyD family secretion protein TruB_C_2 PF16198.3 NM_001290496.1_2 - 0.0014 18.5 0.1 0.0026 17.7 0.1 1.4 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Mit_proteolip PF08039.9 NM_001290496.1_2 - 0.012 15.8 3.7 0.028 14.6 3.7 1.6 1 0 0 1 1 1 0 Mitochondrial proteolipid Mit_proteolip PF08039.9 NM_001290496.1_3 - 0.22 11.7 4.7 0.39 10.9 4.7 1.4 1 0 0 1 1 1 0 Mitochondrial proteolipid 7tm_3 PF00003.20 NM_009493.2_3 - 4.9e-60 203.1 29.8 4.9e-60 203.1 29.8 2.1 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_009493.2_3 - 4.3e-34 118.0 0.1 6.1e-34 117.5 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_009493.2_3 - 1.5e-17 63.1 12.5 3.5e-17 62.0 12.5 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 NM_009493.2_3 - 1.8 8.3 9.6 4.9 6.9 9.6 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like AhpC-TSA_2 PF13911.4 NM_025370.2_3 - 1.5e-20 73.3 0.0 2.2e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Redoxin PF08534.8 NM_025370.2_3 - 1.3e-05 24.7 0.0 1.9e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.19 NM_025370.2_3 - 2.5e-05 24.0 0.0 3.7e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family DUF899 PF05988.10 NM_025370.2_3 - 0.034 13.5 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) Patatin PF01734.20 NM_001163689.1_1 - 5.1e-14 52.8 2.5 4.5e-13 49.7 2.5 2.2 1 1 0 1 1 1 1 Patatin-like phospholipase Keratin_B2 PF01500.15 NM_027157.3_1 - 6.1e-47 159.5 94.9 1.9e-38 131.9 57.3 2.2 1 1 1 2 2 2 2 Keratin, high sulfur B2 protein Keratin_B2_2 PF13885.4 NM_027157.3_1 - 2.3e-05 24.1 99.4 0.00065 19.5 32.5 3.8 2 1 1 3 3 3 3 Keratin, high sulfur B2 protein RDM PF11002.6 NM_027157.3_1 - 0.0026 17.5 0.0 0.0043 16.8 0.0 1.3 1 0 0 1 1 1 1 RFPL defining motif (RDM) Myosin_tail_1 PF01576.17 NM_175260.2_3 - 0 1703.4 313.7 0 1703.2 313.7 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 NM_175260.2_3 - 0 1022.2 0.9 0 1022.2 0.9 3.0 4 0 0 4 4 4 1 Myosin head (motor domain) Myosin_N PF02736.17 NM_175260.2_3 - 1.3e-12 47.2 0.1 3.4e-12 45.8 0.1 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 NM_175260.2_3 - 0.00011 21.5 0.2 0.00039 19.8 0.2 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif ADIP PF11559.6 NM_175260.2_3 - 0.00011 22.2 21.3 0.00011 22.2 21.3 14.3 2 2 12 14 14 14 4 Afadin- and alpha -actinin-Binding AAA_22 PF13401.4 NM_175260.2_3 - 0.1 12.7 0.0 0.1 12.7 0.0 6.0 5 2 1 6 6 6 0 AAA domain Reo_sigmaC PF04582.10 NM_175260.2_3 - 7.5 5.7 72.8 0.24 10.6 0.9 8.7 3 2 5 10 10 10 0 Reovirus sigma C capsid protein ATP1G1_PLM_MAT8 PF02038.14 NM_008761.4_3 - 1.2e-17 62.8 0.1 2.2e-17 62.0 0.1 1.4 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family Yip1 PF04893.15 NM_001205157.1_1 - 2.1e-19 69.7 8.3 2.9e-19 69.3 7.9 1.4 1 1 0 1 1 1 1 Yip1 domain DUF2070 PF09843.7 NM_001205157.1_1 - 0.48 8.5 4.3 0.66 8.1 4.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF1866 PF08952.9 NM_001290698.1_1 - 8.9e-60 200.6 0.1 1.4e-59 200.0 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.21 NM_001290698.1_1 - 1.9e-07 31.2 0.0 4.4e-07 30.0 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family VIT_2 PF13757.4 NM_001144953.1_3 - 3e-30 103.8 0.0 6.1e-30 102.8 0.0 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.4 NM_001144953.1_3 - 1.7e-27 96.1 0.0 2.8e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.8 NM_001144953.1_3 - 0.00011 22.3 0.0 0.00019 21.5 0.0 1.3 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain Ints3 PF10189.7 NM_145540.3_3 - 5.8e-107 355.9 0.1 1.1e-106 355.1 0.1 1.5 1 0 0 1 1 1 1 Integrator complex subunit 3 SKA1 PF07160.10 NM_145540.3_3 - 1.3 8.7 7.7 2.3 7.8 5.0 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 PALP PF00291.23 NM_145565.1_3 - 1.4e-74 251.1 0.4 1.7e-74 250.8 0.4 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PAS_3 PF08447.10 NM_013464.4_1 - 2.6e-19 69.2 0.2 2.8e-13 49.8 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 NM_013464.4_1 - 1e-13 51.1 0.1 4.8e-12 45.7 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.4 NM_013464.4_1 - 1.2e-10 41.3 0.1 7.1e-08 32.4 0.0 2.5 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 NM_013464.4_1 - 2.4e-05 24.1 0.2 5.1e-05 23.0 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.8 NM_013464.4_1 - 0.0023 18.0 2.0 0.042 14.0 0.1 2.9 3 0 0 3 3 3 1 PAS fold C2-set_2 PF08205.10 NM_013464.4_3 - 0.0059 16.5 0.1 0.014 15.3 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain zf-CCHC PF00098.21 NM_001033795.4_1 - 0.15 12.1 1.0 0.31 11.0 1.0 1.5 1 0 0 1 1 1 0 Zinc knuckle TGF_beta PF00019.18 NM_008110.2_1 - 4.9e-26 91.5 0.2 1.2e-25 90.3 0.2 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain K_channel_TID PF07941.9 NM_178246.3_1 - 0.23 11.8 4.5 0.59 10.5 4.5 1.6 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain EST1_DNA_bind PF10373.7 NM_178246.3_3 - 6.6e-39 133.9 5.3 5.7e-32 111.2 1.6 2.3 2 0 0 2 2 2 2 Est1 DNA/RNA binding domain EST1 PF10374.7 NM_178246.3_3 - 4.5e-24 85.5 5.2 6.2e-24 85.0 1.6 3.1 4 0 0 4 4 4 1 Telomerase activating protein Est1 PIN_4 PF13638.4 NM_178246.3_3 - 4.3e-05 23.7 0.0 0.00011 22.4 0.0 1.7 1 0 0 1 1 1 1 PIN domain NNMT_PNMT_TEMT PF01234.15 NM_008890.1_1 - 1.3e-91 306.2 0.0 1.5e-91 306.0 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.4 NM_008890.1_1 - 0.0077 16.0 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_008890.1_1 - 0.053 14.0 0.0 0.28 11.7 0.0 2.1 1 1 0 2 2 2 0 Methyltransferase domain ProSAAS PF07259.10 NM_008890.1_1 - 0.064 13.1 0.2 0.16 11.8 0.2 1.6 1 0 0 1 1 1 0 ProSAAS precursor Methyltransf_12 PF08242.10 NM_008890.1_1 - 0.12 12.9 0.0 0.29 11.7 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain 7tm_4 PF13853.4 NM_146903.2_1 - 4.9e-51 174.0 23.4 5.8e-51 173.7 23.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146903.2_1 - 1.7e-27 96.2 21.8 3.7e-27 95.1 21.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146903.2_1 - 7e-07 28.7 23.7 1.2e-06 28.0 23.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_146903.2_1 - 0.066 12.4 23.4 0.087 12.0 22.5 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_3 PF00003.20 NM_001105187.1_1 - 1.4e-56 191.8 32.8 1.4e-56 191.8 32.8 2.2 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001105187.1_1 - 1.4e-26 93.3 0.1 2.4e-26 92.6 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001105187.1_1 - 1.1e-17 63.5 11.8 2.6e-17 62.4 11.8 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR PKD PF00801.18 NM_021882.4_2 - 4.6e-12 45.5 0.0 5.4e-11 42.0 0.0 2.7 2 0 0 2 2 2 1 PKD domain LEAP-2 PF07359.9 NM_021882.4_3 - 0.081 12.6 0.3 0.081 12.6 0.3 2.4 2 0 0 2 2 2 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) 7tm_4 PF13853.4 NM_147009.3_1 - 2.8e-55 187.9 27.8 3.4e-55 187.6 27.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147009.3_1 - 2.9e-25 88.9 28.6 8.6e-25 87.3 28.6 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147009.3_1 - 6.4e-05 22.3 27.9 9.2e-05 21.8 27.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Cu-oxidase_3 PF07732.13 NM_001164797.1_2 - 5.2e-28 97.3 0.0 8.8e-10 38.5 0.0 4.2 4 0 0 4 4 4 3 Multicopper oxidase Cu-oxidase_2 PF07731.12 NM_001164797.1_2 - 4.8e-23 81.3 10.8 2.5e-11 43.3 1.5 4.8 4 1 0 4 4 4 4 Multicopper oxidase Cor1 PF04803.10 NM_001099919.2_1 - 6e-09 36.1 8.0 1.4e-08 34.9 8.0 1.5 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region Neurexophilin PF06312.10 NM_008751.5_2 - 4.1e-112 372.6 2.6 5.6e-112 372.2 2.6 1.2 1 0 0 1 1 1 1 Neurexophilin A_deamin PF02137.16 NM_013925.4_3 - 3.7e-119 397.8 0.0 4.6e-119 397.5 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Complex1_LYR PF05347.13 NM_001163628.1_3 - 1.8e-12 47.0 0.0 3.1e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 NM_001163628.1_3 - 3.5e-05 24.3 1.1 5.7e-05 23.6 1.1 1.3 1 0 0 1 1 1 1 Complex1_LYR-like TPR_2 PF07719.15 NM_145607.3_2 - 1.9e-16 58.6 7.1 4.8e-06 26.2 0.3 5.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_145607.3_2 - 4.1e-16 57.9 11.0 2.9e-08 33.1 0.3 5.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.4 NM_145607.3_2 - 3e-10 39.5 0.6 0.00019 20.9 0.2 3.9 2 1 2 4 4 4 3 TPR repeat TPR_19 PF14559.4 NM_145607.3_2 - 1.5e-09 38.1 3.2 4.8e-06 26.9 1.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_145607.3_2 - 1.6e-09 37.0 6.9 8.5e-05 22.4 0.2 5.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_145607.3_2 - 4.2e-09 36.4 8.6 4.3e-06 26.8 1.1 3.2 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_145607.3_2 - 2.1e-08 34.1 3.3 0.025 15.2 0.1 4.9 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_145607.3_2 - 5.2e-06 26.9 0.5 0.00021 21.8 0.0 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.4 NM_145607.3_2 - 1.5e-05 24.9 0.3 0.0001 22.3 0.1 2.5 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_145607.3_2 - 0.00015 21.7 2.8 0.015 15.4 1.3 3.3 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.4 NM_145607.3_2 - 0.00056 19.6 1.7 0.27 11.0 0.1 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_145607.3_2 - 0.0012 18.6 4.5 0.0098 15.7 0.1 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.4 NM_145607.3_2 - 0.0014 18.7 0.6 2.4 8.6 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.16 NM_145607.3_2 - 0.091 12.7 0.1 2.3 8.2 0.0 3.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain DUF2524 PF10732.7 NM_145607.3_2 - 0.11 12.7 1.0 0.27 11.4 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) SHNi-TPR PF10516.7 NM_145607.3_2 - 0.29 10.5 1.4 12 5.3 0.2 2.6 2 0 0 2 2 2 0 SHNi-TPR TPR_6 PF13174.4 NM_145607.3_2 - 0.44 11.2 4.1 8.4 7.1 0.1 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat Sulfotransfer_2 PF03567.12 NM_027928.1_3 - 2.4e-53 181.5 0.0 3.1e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family WD40 PF00400.30 NM_001039388.2_1 - 4.5e-25 87.3 23.9 1.9e-06 28.4 0.4 7.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001039388.2_1 - 0.027 14.6 0.3 3.4 7.9 0.0 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain ICAP-1_inte_bdg PF10480.7 NM_008403.4_3 - 1.8e-123 409.9 5.4 1.8e-123 409.9 5.4 1.4 2 0 0 2 2 2 1 Beta-1 integrin binding protein PID PF00640.21 NM_008403.4_3 - 0.0035 17.2 0.0 0.0065 16.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) FAD_binding_7 PF03441.12 NM_007771.3_2 - 1.7e-69 233.0 0.3 2.8e-69 232.3 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.16 NM_007771.3_2 - 1.4e-44 151.9 0.0 2.3e-44 151.2 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase IL8 PF00048.18 NM_011330.3_1 - 2.1e-20 72.5 3.1 4.1e-20 71.6 3.1 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like BTG PF07742.10 NM_001243943.1_1 - 3.8e-40 136.2 0.0 4.9e-40 135.9 0.0 1.1 1 0 0 1 1 1 1 BTG family DNA_methylase PF00145.15 NM_001271753.1_3 - 7e-15 55.1 0.0 4e-11 42.7 0.0 2.4 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase PWWP PF00855.15 NM_001271753.1_3 - 1.4e-11 44.5 0.4 3.8e-11 43.2 0.4 1.7 1 0 0 1 1 1 1 PWWP domain ParA PF10609.7 NM_029760.2_3 - 4.6e-99 330.7 0.4 6e-99 330.3 0.4 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.21 NM_029760.2_3 - 8.5e-11 41.9 0.0 1.8e-10 40.8 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.4 NM_029760.2_3 - 2.3e-08 34.0 0.3 6.4e-07 29.3 0.2 2.1 2 0 0 2 2 2 1 AAA domain MipZ PF09140.9 NM_029760.2_3 - 4.4e-07 29.3 0.0 8.5e-07 28.4 0.0 1.6 1 1 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.16 NM_029760.2_3 - 1.3e-06 28.0 0.0 0.0067 15.8 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.13 NM_029760.2_3 - 9.2e-05 21.7 0.3 0.002 17.3 0.4 2.7 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_25 PF13481.4 NM_029760.2_3 - 0.0036 16.8 0.0 0.007 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain VirC1 PF07015.9 NM_029760.2_3 - 0.098 11.8 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 VirC1 protein Spc97_Spc98 PF04130.11 NM_001286011.1_3 - 1.3e-120 403.6 13.1 3.4e-120 402.3 13.1 1.6 1 1 0 1 1 1 1 Spc97 / Spc98 family Guanylate_cyc PF00211.18 NM_017469.4_3 - 6e-66 221.4 0.0 8.5e-66 220.9 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.12 NM_017469.4_3 - 8.6e-57 191.9 0.0 1.3e-56 191.3 0.0 1.3 1 0 0 1 1 1 1 Heme NO binding associated HNOB PF07700.13 NM_017469.4_3 - 2.3e-55 186.9 0.0 3.2e-55 186.4 0.0 1.2 1 0 0 1 1 1 1 Haem-NO-binding 4_1_CTD PF05902.11 NM_017469.4_3 - 0.14 12.2 0.1 0.25 11.4 0.1 1.3 1 0 0 1 1 1 0 4.1 protein C-terminal domain (CTD) Cullin PF00888.20 NM_001161618.1_3 - 1.9e-171 571.7 18.9 1.5e-129 433.3 8.5 2.1 1 1 1 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.7 NM_001161618.1_3 - 2.1e-16 59.6 6.7 5.5e-16 58.2 6.7 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain Stork_head PF10264.7 NM_001161618.1_3 - 0.043 13.8 0.6 0.12 12.4 0.6 1.7 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain C6_DPF PF10170.7 NM_001164626.1_3 - 7e-37 125.6 4.1 8.9e-37 125.3 4.1 1.1 1 0 0 1 1 1 1 Cysteine-rich domain Calcyon PF06387.9 NM_001190385.1_2 - 4.1e-76 254.9 0.0 5.1e-76 254.6 0.0 1.1 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) DUF3808 PF10300.7 NM_153392.2_1 - 2.9e-167 557.1 2.6 2.9e-167 557.1 2.6 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_12 PF13424.4 NM_153392.2_1 - 3e-08 33.7 3.6 2.6e-06 27.5 0.5 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_153392.2_1 - 1.2e-07 32.2 0.9 0.028 15.0 0.0 3.3 3 1 0 3 3 2 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_153392.2_1 - 8.2e-06 25.4 6.8 0.076 13.0 0.7 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_153392.2_1 - 3.8e-05 23.4 2.1 0.67 10.2 0.3 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_153392.2_1 - 6.6e-05 23.3 0.6 0.023 15.4 0.0 4.0 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.26 NM_153392.2_1 - 0.00012 21.6 4.8 0.13 12.0 0.8 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_153392.2_1 - 0.0016 18.8 6.8 0.12 12.8 1.0 5.3 5 2 1 6 6 5 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_153392.2_1 - 0.0026 18.2 5.3 0.0089 16.5 0.5 4.2 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 NM_153392.2_1 - 0.0042 16.9 0.5 0.097 12.6 0.1 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.8 NM_153392.2_1 - 0.015 14.8 0.6 2.6 7.6 0.0 3.3 3 1 1 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) ANAPC3 PF12895.5 NM_153392.2_1 - 0.091 12.8 16.7 3.6 7.7 0.1 5.2 5 1 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.4 NM_153392.2_1 - 0.16 11.8 4.6 1.9 8.4 0.4 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat ROK PF00480.18 NM_153392.2_1 - 0.17 11.2 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 ROK family CYSTM PF12734.5 NM_153392.2_1 - 2.2 8.6 6.3 0.98 9.7 2.6 2.2 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance LisH_2 PF16045.3 NM_001252192.1_3 - 0.023 13.6 0.1 0.045 12.7 0.1 1.5 1 0 0 1 1 1 0 LisH DUF2052 PF09747.7 NM_028771.2_1 - 2.1e-47 161.7 19.7 5.4e-46 157.1 19.7 2.2 1 1 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) T-box PF00907.20 NM_001164274.1_1 - 6.9e-73 244.7 0.4 2.2e-72 243.0 0.0 2.1 2 0 0 2 2 2 1 T-box DUF4801 PF16059.3 NM_001164274.1_1 - 2e-16 59.5 8.9 5e-16 58.3 8.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4801) HLH PF00010.24 NM_001164274.1_1 - 9.9e-09 34.9 0.3 3.2e-08 33.3 0.3 2.0 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Tap-RNA_bind PF09162.8 NM_001276704.1_2 - 2.2e-38 129.8 0.2 3.6e-38 129.2 0.2 1.4 1 0 0 1 1 1 1 Tap, RNA-binding LRR_8 PF13855.4 NM_001276704.1_2 - 5.3e-05 22.8 2.7 9.1e-05 22.0 2.7 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.5 NM_001276704.1_2 - 0.00014 22.0 5.9 0.0026 18.0 0.8 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_001276704.1_2 - 0.012 15.0 0.2 0.018 14.4 0.2 1.2 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.4 NM_001276704.1_2 - 0.079 12.9 1.5 1.1 9.4 0.1 2.7 2 0 0 2 2 2 0 Leucine Rich repeat LRR_1 PF00560.31 NM_001276704.1_2 - 8.8 7.1 7.9 9.1 7.1 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat NTF2 PF02136.18 NM_001276704.1_3 - 1.1e-26 93.6 0.0 1.6e-26 93.1 0.0 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain TAP_C PF03943.11 NM_001276704.1_3 - 5.3e-25 86.6 1.1 1e-24 85.7 1.1 1.5 1 0 0 1 1 1 1 TAP C-terminal domain PX PF00787.22 NM_001302476.1_3 - 1.4e-27 95.8 0.1 2.6e-27 94.9 0.1 1.5 1 0 0 1 1 1 1 PX domain PH PF00169.27 NM_001302476.1_3 - 9e-05 22.8 0.1 0.00023 21.5 0.1 1.7 1 1 0 1 1 1 1 PH domain PH_2 PF08458.8 NM_001302476.1_3 - 0.15 12.3 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 Plant pleckstrin homology-like region HIG_1_N PF04588.11 NM_019814.4_2 - 3.2e-17 62.4 1.1 8e-17 61.1 1.1 1.7 1 0 0 1 1 1 1 Hypoxia induced protein conserved region ubiquitin PF00240.21 NM_024277.2_2 - 2e-34 117.0 0.3 3.5e-34 116.2 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.17 NM_024277.2_2 - 4.2e-27 93.9 4.6 8.2e-27 93.0 4.6 1.5 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.6 NM_024277.2_2 - 1.6e-16 59.7 0.4 2.9e-16 58.9 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 NM_024277.2_2 - 8.3e-06 26.0 0.5 6.6e-05 23.1 0.2 2.5 2 1 1 3 3 3 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 NM_024277.2_2 - 0.00038 20.4 0.7 0.00073 19.5 0.7 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 NM_024277.2_2 - 0.018 15.5 0.8 0.029 14.8 0.8 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain GBP PF02263.17 NM_001256005.1_1 - 6.7e-09 35.3 0.1 1.1e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 NM_001256005.1_3 - 1.8e-116 388.6 22.7 2.5e-116 388.1 22.7 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain GBP PF02263.17 NM_001256005.1_3 - 8.7e-91 303.6 0.0 2.2e-90 302.3 0.0 1.7 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain DUF3584 PF12128.6 NM_001256005.1_3 - 0.016 12.6 23.3 0.031 11.7 23.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MMR_HSR1 PF01926.21 NM_001256005.1_3 - 0.076 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Tho2 PF11262.6 NM_001256005.1_3 - 0.29 10.2 13.6 0.62 9.1 13.6 1.5 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 BRICHOS PF04089.12 NM_001256005.1_3 - 0.31 11.0 1.8 21 5.2 1.1 2.8 2 0 0 2 2 2 0 BRICHOS domain Phlebovirus_NSM PF07246.9 NM_001256005.1_3 - 0.52 9.5 9.5 0.9 8.7 9.5 1.3 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF258 PF03193.14 NM_001256005.1_3 - 0.55 10.0 2.1 0.77 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 MnmE_helical PF12631.5 NM_001256005.1_3 - 0.61 10.1 6.4 1.9 8.5 6.4 1.7 1 1 0 1 1 1 0 MnmE helical domain Ribosomal_L37 PF08561.8 NM_001256005.1_3 - 1.1 9.7 8.9 3.4 8.1 8.9 1.8 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 MtaB PF12176.6 NM_001256005.1_3 - 1.2 7.7 6.8 1.8 7.1 6.8 1.2 1 0 0 1 1 1 0 Methanol-cobalamin methyltransferase B subunit DUF4407 PF14362.4 NM_001256005.1_3 - 2 7.5 9.5 3.9 6.6 9.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ABC_tran PF00005.25 NM_001256005.1_3 - 2.4 8.5 0.0 2.4 8.5 0.0 3.1 2 1 0 2 2 1 0 ABC transporter DUF342 PF03961.11 NM_001256005.1_3 - 6.4 5.1 12.6 11 4.3 12.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) V-SNARE PF05008.13 NM_001293685.1_2 - 6.3e-25 87.2 0.5 1.1e-24 86.4 0.5 1.5 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.6 NM_001293685.1_2 - 9.7e-20 70.5 5.3 9.7e-20 70.5 5.3 1.7 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.11 NM_001293685.1_2 - 0.12 12.1 0.1 0.34 10.7 0.1 1.7 1 0 0 1 1 1 0 Sec20 DUF1664 PF07889.10 NM_001293685.1_2 - 0.25 11.2 0.9 2.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.13 NM_001293685.1_2 - 0.79 9.1 5.8 1.7 8.0 5.6 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit KxDL PF10241.7 NM_029366.2_2 - 3.4e-30 104.0 1.7 5.4e-30 103.4 1.7 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein TolA_bind_tri PF16331.3 NM_029366.2_2 - 0.032 14.2 0.1 0.057 13.4 0.1 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation Snapin_Pallidin PF14712.4 NM_029366.2_2 - 0.27 11.6 1.8 0.51 10.7 1.8 1.3 1 0 0 1 1 1 0 Snapin/Pallidin MutS_V PF00488.19 NM_001311120.1_2 - 3.8e-71 238.9 0.1 1.2e-70 237.3 0.0 1.9 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.16 NM_001311120.1_2 - 3.2e-37 128.5 1.4 1.5e-36 126.3 0.3 2.5 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.15 NM_001311120.1_2 - 1.5e-33 115.9 0.1 5.1e-33 114.1 0.1 2.0 1 0 0 1 1 1 1 MutS domain II MutS_I PF01624.18 NM_001311120.1_2 - 2e-32 111.6 0.1 4.1e-32 110.7 0.1 1.5 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.16 NM_001311120.1_2 - 0.00022 21.4 0.0 0.00069 19.8 0.0 1.9 1 0 0 1 1 1 1 MutS family domain IV NPV_P10 PF05531.10 NM_001311120.1_2 - 0.069 13.5 0.4 1 9.7 0.1 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein CNPase PF05881.10 NM_009923.2_2 - 4.7e-120 399.3 0.0 6.6e-120 398.8 0.0 1.2 1 0 0 1 1 1 1 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) AAA_33 PF13671.4 NM_009923.2_2 - 8.1e-08 32.4 0.0 1.7e-07 31.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain 6PF2K PF01591.16 NM_009923.2_2 - 0.0016 17.7 0.0 1.6 7.9 0.0 2.1 2 0 0 2 2 2 2 6-phosphofructo-2-kinase AAA_22 PF13401.4 NM_009923.2_2 - 0.0026 17.9 0.3 0.018 15.2 0.3 2.1 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 NM_009923.2_2 - 0.0035 16.5 0.0 0.007 15.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.4 NM_009923.2_2 - 0.0036 17.6 0.1 0.0076 16.5 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain KTI12 PF08433.8 NM_009923.2_2 - 0.0051 16.1 0.0 0.0077 15.6 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA PF00004.27 NM_009923.2_2 - 0.022 15.0 0.0 0.041 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.4 NM_009923.2_2 - 0.026 14.9 0.0 0.047 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.4 NM_009923.2_2 - 0.029 14.7 0.0 0.063 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.25 NM_009923.2_2 - 0.03 14.7 0.0 0.055 13.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_14 PF13173.4 NM_009923.2_2 - 0.058 13.3 0.0 0.18 11.7 0.0 1.7 1 1 1 2 2 2 0 AAA domain AAA_30 PF13604.4 NM_009923.2_2 - 0.06 12.9 0.0 0.13 11.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.12 NM_009923.2_2 - 0.084 12.7 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.20 NM_009923.2_2 - 0.29 10.0 0.8 2.4 7.0 0.0 2.2 2 1 1 3 3 3 0 NB-ARC domain TPR_1 PF00515.26 NM_133726.2_2 - 3.7e-12 45.4 2.0 3.3e-05 23.4 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 NM_133726.2_2 - 5.6e-12 44.7 3.9 0.015 15.3 1.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.4 NM_133726.2_2 - 1.1e-08 34.4 0.1 0.00069 19.1 0.0 3.0 1 1 2 3 3 3 2 TPR repeat TPR_9 PF13371.4 NM_133726.2_2 - 2e-07 30.9 3.3 1.2e-05 25.2 1.4 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_133726.2_2 - 7.4e-07 29.6 0.5 0.0011 19.4 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_133726.2_2 - 9.5e-07 28.7 0.0 0.018 15.3 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_133726.2_2 - 2.1e-05 24.2 0.4 0.035 14.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_133726.2_2 - 0.00013 22.4 6.4 0.069 13.9 0.0 3.8 2 1 2 4 4 3 2 Tetratricopeptide repeat Rrn6 PF10214.7 NM_133726.2_2 - 0.0025 16.2 1.5 0.013 13.8 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase I-specific transcription-initiation factor TPR_19 PF14559.4 NM_133726.2_2 - 0.04 14.3 1.1 0.21 12.0 0.1 2.5 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 NM_133726.2_2 - 0.064 13.4 1.2 0.88 9.8 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.4 NM_133726.2_2 - 0.13 12.2 0.2 75 3.6 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Ndufs5 PF10200.7 NM_133726.2_2 - 0.45 10.7 3.2 0.44 10.7 1.4 2.0 2 1 0 2 2 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Forkhead_N PF08430.10 NM_133726.2_2 - 3.6 8.1 8.9 7.2 7.1 8.9 1.4 1 0 0 1 1 1 0 Forkhead N-terminal region Hox9_act PF04617.11 NM_133726.2_2 - 7 7.3 10.8 0.084 13.5 1.9 1.9 2 0 0 2 2 2 0 Hox9 activation region Glyco_transf_54 PF04666.11 NM_145926.3_3 - 9.2e-135 448.0 0.0 1.3e-134 447.5 0.0 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region STAR_dimer PF16544.3 NM_145926.3_3 - 0.3 10.6 1.8 0.29 10.6 0.2 1.8 2 0 0 2 2 2 0 Homodimerisation region of STAR domain protein MFS_1 PF07690.14 NM_146136.1_3 - 8.3e-40 136.7 19.6 2.7e-24 85.7 8.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Zip PF02535.20 NM_146136.1_3 - 0.03 13.4 2.0 3.6 6.6 2.4 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter Mmp37 PF09139.9 NM_026894.1_1 - 1.9e-110 369.2 0.0 2.2e-110 369.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial matrix Mmp37 GDA1_CD39 PF01150.15 NM_178676.4_1 - 2e-98 329.7 0.1 2.9e-98 329.2 0.1 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Tcf25 PF04910.12 NM_001286363.1_1 - 1.6e-116 388.9 1.2 2e-116 388.7 1.2 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 PIP49_C PF12260.6 NM_134117.2_1 - 3.1e-07 30.1 0.0 5.1e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Pkinase PF00069.23 NM_134117.2_1 - 0.00021 20.6 0.0 0.00032 20.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_134117.2_1 - 0.011 14.9 0.0 0.016 14.3 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase zf-RING_2 PF13639.4 NM_001168623.1_1 - 3.7e-08 33.4 4.4 3.7e-08 33.4 4.4 3.7 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.3 NM_001168623.1_1 - 0.00014 21.4 4.5 0.00014 21.4 4.5 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 NM_001168623.1_1 - 0.00075 19.2 6.6 0.0016 18.1 3.6 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.3 NM_001168623.1_1 - 0.0044 16.5 3.2 0.014 14.9 3.2 1.9 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.5 NM_001168623.1_1 - 0.013 15.7 1.6 0.013 15.7 1.6 2.7 3 0 0 3 3 3 0 RING-H2 zinc finger domain RNF220 PF15926.3 NM_001168623.1_1 - 0.18 11.3 0.0 0.27 10.7 0.0 1.1 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Prok-RING_1 PF14446.4 NM_001168623.1_1 - 4 7.3 8.5 18 5.2 3.0 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 LRR_9 PF14580.4 NM_009672.3_3 - 1.7e-17 63.4 1.0 2.6e-17 62.7 1.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 NM_009672.3_3 - 1e-11 44.7 14.4 1.9e-09 37.4 1.7 3.4 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_009672.3_3 - 4e-07 29.6 4.0 4e-07 29.6 4.0 2.8 2 1 1 3 3 3 1 Leucine rich repeat LRR_6 PF13516.4 NM_009672.3_3 - 5.5e-05 22.8 8.6 0.013 15.4 0.4 3.7 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.31 NM_009672.3_3 - 0.031 14.6 7.3 1.1 9.8 0.2 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat BUD22 PF09073.8 NM_009672.3_3 - 0.35 10.0 22.8 0.56 9.4 22.8 1.3 1 0 0 1 1 1 0 BUD22 LRR_2 PF07723.11 NM_009672.3_3 - 4.6 7.9 7.6 26 5.6 0.2 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat Mpp10 PF04006.10 NM_009672.3_3 - 7.5 4.8 28.9 11 4.2 28.9 1.1 1 0 0 1 1 1 0 Mpp10 protein DHR-2 PF06920.11 NM_001009947.3_1 - 3.7e-206 685.7 11.5 6.4e-206 684.9 11.5 1.4 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.4 NM_001009947.3_1 - 2.9e-58 196.7 1.0 1.9e-57 194.1 0.6 2.6 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 NM_001009947.3_1 - 9.8e-37 125.1 0.1 2.6e-36 123.7 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.27 NM_001009947.3_1 - 8.7e-11 42.1 0.5 8.7e-11 42.1 0.5 2.5 2 0 0 2 2 2 1 PH domain TBCC PF07986.10 NM_001290643.1_1 - 3.7e-46 155.6 6.4 6.4e-46 154.9 6.4 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.9 NM_001290643.1_1 - 2.6e-05 23.8 1.8 6.3e-05 22.5 1.8 1.6 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal NDK PF00334.17 NM_001290643.1_1 - 0.00017 21.5 0.0 0.00027 20.8 0.0 1.3 1 0 0 1 1 1 1 Nucleoside diphosphate kinase 2OG-FeII_Oxy_3 PF13640.4 NM_001286148.1_1 - 3.7e-10 40.4 0.0 9.5e-10 39.1 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.18 NM_001286148.1_1 - 1.3e-09 38.4 0.0 2.8e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.15 NM_001286148.1_1 - 1.4e-06 27.8 2.8 0.63 10.2 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001286148.1_1 - 0.0019 17.8 3.6 0.69 9.7 0.2 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001286148.1_1 - 0.0055 17.1 0.1 6.3 7.3 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001286148.1_1 - 0.013 16.1 0.1 3 8.8 0.0 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat YfiO PF13525.4 NM_001286148.1_1 - 0.021 14.4 5.2 1.9 8.0 0.4 2.7 2 1 0 2 2 2 0 Outer membrane lipoprotein Fis1_TPR_C PF14853.4 NM_001286148.1_1 - 0.13 12.3 1.6 0.9 9.5 0.3 2.5 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.4 NM_001286148.1_1 - 9 6.5 6.5 1.2e+02 2.9 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat VEGF_C PF14554.4 NM_001025250.3_2 - 9e-28 96.0 18.6 9e-28 96.0 18.6 2.2 2 0 0 2 2 2 1 VEGF heparin-binding domain PDGF PF00341.15 NM_001025250.3_2 - 9e-26 89.9 6.3 9e-26 89.9 6.3 2.4 3 0 0 3 3 3 1 PDGF/VEGF domain TGFb_propeptide PF00688.16 NM_007558.3_2 - 1.7e-65 221.0 0.0 2.4e-65 220.6 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 NM_007558.3_2 - 2.8e-35 121.2 1.8 4.7e-35 120.5 1.8 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain 7tm_4 PF13853.4 NM_146664.1_1 - 3.6e-39 135.1 21.4 4.5e-39 134.7 21.4 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146664.1_1 - 1.2e-22 80.4 20.9 1.2e-22 80.4 20.9 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_146664.1_1 - 0.61 9.5 7.6 1 8.8 0.3 2.6 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus TRAM1 PF08390.9 NM_001001735.2_2 - 0.073 12.6 0.1 0.073 12.6 0.1 2.3 2 0 0 2 2 2 0 TRAM1-like protein PWWP PF00855.15 NM_001001735.2_3 - 2.1e-21 76.1 1.8 2.1e-21 76.1 1.8 2.3 2 0 0 2 2 2 1 PWWP domain C2 PF00168.28 NM_029212.3_2 - 7.2e-09 35.7 0.1 1.1e-06 28.7 0.1 2.4 2 0 0 2 2 2 2 C2 domain Pox_A_type_inc PF04508.10 NM_029212.3_2 - 3.1 7.7 12.1 0.34 10.7 0.8 3.3 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat PEP-utilisers_N PF05524.11 NM_029212.3_2 - 7.4 6.6 11.0 1.3 9.0 1.3 2.7 1 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal zf-RING_2 PF13639.4 NM_021470.6_2 - 4.1e-15 55.6 19.1 2e-09 37.4 7.8 3.5 2 1 0 2 2 2 2 Ring finger domain zf-RING_UBOX PF13445.4 NM_021470.6_2 - 1.7e-13 50.2 15.3 6e-09 35.6 6.6 3.3 2 1 1 3 3 3 2 RING-type zinc-finger zf-RING_5 PF14634.4 NM_021470.6_2 - 1.3e-12 47.4 16.2 3.5e-06 26.7 7.8 2.7 2 0 0 2 2 2 2 zinc-RING finger domain zf-rbx1 PF12678.5 NM_021470.6_2 - 9.8e-10 38.4 13.1 6.7e-06 26.2 5.3 2.9 2 0 0 2 2 2 2 RING-H2 zinc finger domain zf-RING_11 PF17123.3 NM_021470.6_2 - 1.8e-09 37.0 13.3 0.00095 18.7 6.2 3.7 3 0 0 3 3 3 3 RING-like zinc finger zf-C3HC4 PF00097.23 NM_021470.6_2 - 1.8e-09 37.2 19.1 7.1e-06 25.7 8.4 3.2 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_021470.6_2 - 1.3e-07 31.2 17.3 6.6e-05 22.6 5.6 3.5 2 1 1 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 NM_021470.6_2 - 1.5e-07 31.2 10.8 2.8e-05 24.0 2.9 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 NM_021470.6_2 - 2.3e-07 30.4 20.6 0.0011 18.6 8.1 4.0 3 1 1 4 4 4 2 Prokaryotic RING finger family 4 IQ PF00612.25 NM_021470.6_2 - 1.2e-06 27.6 4.1 4.4e-06 25.9 4.1 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif zf-C3HC4_2 PF13923.4 NM_021470.6_2 - 1.4e-05 24.7 8.9 1.4e-05 24.7 8.9 4.0 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.3 NM_021470.6_2 - 0.03 13.8 14.7 0.046 13.2 3.6 3.1 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type Pellino PF04710.12 NM_021470.6_2 - 0.059 11.9 6.5 0.25 9.8 0.6 2.2 2 0 0 2 2 2 0 Pellino zf-C3HC4_4 PF15227.4 NM_021470.6_2 - 0.093 12.8 18.1 0.091 12.8 7.3 3.1 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.4 NM_021470.6_2 - 0.099 12.3 13.4 0.038 13.6 3.6 3.1 3 1 0 3 3 2 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.6 NM_021470.6_2 - 0.12 12.1 10.9 0.082 12.6 5.4 2.4 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-C3H2C3 PF17122.3 NM_021470.6_2 - 1.1 9.2 21.1 3.1 7.8 8.0 4.2 4 1 0 4 4 4 0 Zinc-finger WD40 PF00400.30 NM_028334.4_3 - 8.4e-13 48.5 3.2 3e-05 24.5 0.0 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_028334.4_3 - 9.6e-05 22.5 0.1 0.052 13.7 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1308 PF07000.9 NM_134067.4_3 - 5.7e-115 384.1 0.5 6.8e-115 383.9 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) C2-set_2 PF08205.10 NM_027865.2_1 - 4.8e-16 58.5 0.1 2.3e-13 49.9 0.0 2.4 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 NM_027865.2_1 - 6.8e-06 26.5 0.0 0.0023 18.4 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_027865.2_1 - 0.011 15.6 0.0 0.78 9.7 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_027865.2_1 - 0.071 13.3 1.8 0.78 10.0 0.0 3.1 3 1 0 3 3 3 0 Immunoglobulin domain 7tm_1 PF00001.19 NM_205783.2_1 - 3.3e-78 262.5 4.9 4.5e-78 262.1 4.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 NM_205783.2_1 - 2.8e-06 26.7 4.5 2.8e-06 26.7 4.5 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 NM_205783.2_1 - 9.9e-05 22.1 1.6 9.9e-05 22.1 1.6 2.3 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srbc PF10316.7 NM_205783.2_1 - 0.006 16.0 7.4 0.006 16.0 7.4 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc DUF2693 PF10902.6 NM_205783.2_1 - 0.022 14.6 0.3 0.056 13.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2693) NGF PF00243.16 NM_001285418.1_1 - 3.3e-47 159.2 2.3 5.5e-47 158.5 2.3 1.4 1 0 0 1 1 1 1 Nerve growth factor family p450 PF00067.20 NM_001167877.1_1 - 3.9e-57 193.9 0.0 1.7e-52 178.6 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Collagen PF01391.16 NM_001177942.1_2 - 1.7e-05 24.3 40.2 1.7e-05 24.3 40.2 3.5 3 1 0 3 3 3 2 Collagen triple helix repeat (20 copies) TNF PF00229.16 NM_001177942.1_2 - 0.0029 17.4 0.0 0.0048 16.7 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family EF1_GNE PF00736.17 NM_001285431.1_3 - 2.5e-36 123.6 0.4 5.3e-36 122.5 0.4 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 NM_001285431.1_3 - 1.9e-12 47.2 10.5 1.9e-12 47.2 10.5 1.9 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region JIP_LZII PF16471.3 NM_001285431.1_3 - 0.0012 18.9 0.9 0.0028 17.7 0.9 1.6 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II Striatin PF08232.10 NM_001285431.1_3 - 0.017 15.6 2.9 0.027 14.9 2.9 1.2 1 0 0 1 1 1 0 Striatin family Trimer_CC PF08954.9 NM_001285431.1_3 - 0.034 13.6 1.3 0.21 11.1 0.0 2.8 3 0 0 3 3 3 0 Trimerisation motif TSC22 PF01166.16 NM_001285431.1_3 - 0.07 13.3 0.2 7.9 6.8 0.1 2.6 1 1 1 2 2 2 0 TSC-22/dip/bun family KASH_CCD PF14662.4 NM_001285431.1_3 - 0.093 12.4 1.4 0.3 10.8 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH PilJ PF13675.4 NM_001285431.1_3 - 0.14 12.1 0.2 0.37 10.7 0.2 1.7 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term MinC_N PF05209.11 NM_001285431.1_3 - 0.18 11.6 0.1 2.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain PRKG1_interact PF15898.3 NM_001285431.1_3 - 0.25 12.2 3.8 0.64 10.8 3.8 1.6 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain PP2C PF00481.19 NM_026447.4_2 - 8.6e-32 110.6 0.0 2e-14 53.7 0.0 3.0 2 1 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.10 NM_026447.4_2 - 2.9e-10 40.3 0.5 9.8e-05 22.2 0.2 2.1 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.4 NM_026447.4_2 - 0.0017 17.9 0.0 0.0046 16.5 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C RhoGAP PF00620.25 NM_001005508.2_2 - 2.1e-43 147.6 0.2 3.8e-43 146.8 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain JmjC PF02373.20 NM_021878.3_3 - 3.4e-34 117.6 1.6 6.9e-34 116.6 0.5 2.2 2 0 0 2 2 2 1 JmjC domain, hydroxylase ARID PF01388.19 NM_021878.3_3 - 3.3e-13 50.0 0.0 8.6e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.15 NM_021878.3_3 - 4.6e-13 48.7 0.1 1.3e-12 47.3 0.1 1.8 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.14 NM_021878.3_3 - 3e-08 33.8 8.8 6.7e-08 32.6 7.0 2.6 2 0 0 2 2 2 1 C5HC2 zinc finger Anoctamin PF04547.10 NM_153589.2_2 - 1.3e-155 518.3 4.7 1.7e-155 518.0 4.7 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 NM_153589.2_2 - 1.7e-78 263.3 0.0 3.2e-78 262.4 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin zf-C2H2_assoc2 PF16624.3 NM_001081678.1_1 - 1.2e-33 115.9 15.1 1.2e-33 115.9 15.1 3.2 3 1 0 3 3 2 1 Unstructured region upstream of a zinc-finger zf-C2H2_11 PF16622.3 NM_001081678.1_1 - 9.8e-14 50.7 5.3 9.8e-14 50.7 5.3 6.3 7 0 0 7 7 7 2 zinc-finger C2H2-type zf-C2H2_4 PF13894.4 NM_001081678.1_1 - 4.1e-13 48.8 60.9 0.0066 17.1 2.0 8.5 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001081678.1_1 - 1e-11 44.4 63.5 0.0044 17.3 1.6 8.4 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_2 PF12756.5 NM_001081678.1_1 - 0.00023 21.3 32.4 0.024 14.8 1.2 7.1 6 1 1 7 7 7 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.6 NM_001081678.1_1 - 0.0011 19.1 1.4 0.0011 19.1 1.4 7.2 7 1 0 7 7 5 3 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 NM_001081678.1_1 - 0.0017 17.9 0.8 0.0017 17.9 0.8 6.1 6 0 0 6 6 5 1 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.3 NM_001081678.1_1 - 0.002 18.3 1.1 0.002 18.3 1.1 3.6 5 0 0 5 5 5 1 C2H2-type zinc ribbon zf-C2H2_9 PF16293.3 NM_001081678.1_1 - 0.0021 17.8 5.8 16 5.3 0.0 4.7 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.10 NM_001081678.1_1 - 0.003 17.7 1.7 0.003 17.7 1.7 5.7 5 0 0 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 NM_001081678.1_1 - 0.0044 17.2 0.7 0.0044 17.2 0.7 7.0 8 0 0 8 8 6 3 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 NM_001081678.1_1 - 0.018 15.4 0.5 0.018 15.4 0.5 10.0 12 1 0 12 12 10 0 Zinc-finger double domain Vps39_2 PF10367.7 NM_147153.3_3 - 2.6e-32 111.4 3.7 2.6e-32 111.4 3.7 2.6 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.7 NM_147153.3_3 - 2.7e-32 111.2 3.1 2.7e-32 111.2 3.1 3.0 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.20 NM_147153.3_3 - 6.1e-30 104.6 0.1 1.3e-29 103.6 0.1 1.5 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.18 NM_147153.3_3 - 2.7e-13 49.9 8.7 2.1e-06 27.5 1.3 3.5 3 1 0 3 3 3 2 Region in Clathrin and VPS Cadherin PF00028.15 NM_009886.2_2 - 2.8e-171 556.4 6.8 2.3e-22 79.1 0.6 9.5 9 0 0 9 9 9 9 Cadherin domain GAIN PF16489.3 NM_009886.2_2 - 4.2e-63 212.4 0.0 6.5e-63 211.8 0.0 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain 7tm_2 PF00002.22 NM_009886.2_2 - 1.2e-56 191.7 16.2 1.7e-56 191.2 16.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Laminin_G_2 PF02210.22 NM_009886.2_2 - 5e-49 165.9 0.3 7.4e-26 91.1 0.0 2.6 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.21 NM_009886.2_2 - 8.2e-24 84.2 0.4 2.2e-15 56.9 0.0 3.5 2 1 0 2 2 2 2 Laminin G domain EGF PF00008.25 NM_009886.2_2 - 6.7e-12 45.3 129.1 3.1e-05 24.1 9.6 10.8 11 1 0 11 11 7 6 EGF-like domain GPS PF01825.19 NM_009886.2_2 - 3.1e-10 40.4 6.2 3.1e-10 40.4 6.2 3.3 2 0 0 2 2 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 NM_009886.2_2 - 1e-08 35.2 2.5 1e-08 35.2 2.5 3.3 2 0 0 2 2 2 1 Hormone receptor domain Laminin_EGF PF00053.22 NM_009886.2_2 - 1.4e-08 34.6 13.0 1.4e-08 34.6 13.0 9.5 6 2 4 10 10 7 3 Laminin EGF domain Dicty_CAR PF05462.9 NM_009886.2_2 - 6.9e-08 31.8 3.7 1.3e-07 30.9 3.7 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Cadherin_pro PF08758.9 NM_009886.2_2 - 4.6e-06 26.6 0.0 0.041 13.9 0.0 4.6 6 0 0 6 6 4 1 Cadherin prodomain like Cadherin_2 PF08266.10 NM_009886.2_2 - 3.5e-05 23.4 0.1 9.3 6.0 0.0 7.0 8 0 0 8 8 8 1 Cadherin-like hEGF PF12661.5 NM_009886.2_2 - 4.7e-05 23.8 91.3 0.00036 21.0 4.0 10.2 9 0 0 9 9 9 4 Human growth factor-like EGF PepSY PF03413.17 NM_009886.2_2 - 0.0011 19.4 1.3 0.015 15.7 0.0 3.3 4 0 0 4 4 4 1 Peptidase propeptide and YPEB domain Frizzled PF01534.15 NM_009886.2_2 - 0.45 9.4 8.7 0.8 8.6 8.7 1.3 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region Frag1 PF10277.7 NM_009886.2_2 - 6.2 6.2 11.9 0.1 12.0 3.6 1.9 2 0 0 2 2 2 0 Frag1/DRAM/Sfk1 family DUF4661 PF15576.4 NM_033477.2_2 - 1.6e-136 454.0 3.1 2.1e-136 453.6 3.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4661) SapB_2 PF03489.15 NM_001282071.2_1 - 5.2e-17 61.5 17.3 5.3e-10 39.1 0.4 4.4 5 0 0 5 5 5 3 Saposin-like type B, region 2 SapA PF02199.13 NM_001282071.2_1 - 2.1e-13 50.0 4.4 2.1e-13 50.0 4.4 2.6 3 0 0 3 3 3 1 Saposin A-type domain SapB_1 PF05184.13 NM_001282071.2_1 - 2e-09 37.2 9.3 1e-08 34.9 2.4 3.7 4 0 0 4 4 4 1 Saposin-like type B, region 1 TilS PF09179.9 NM_001282071.2_1 - 0.0029 17.9 1.1 0.0082 16.5 1.1 1.8 1 0 0 1 1 1 1 TilS substrate binding domain SelP_N PF04592.12 NM_001282071.2_2 - 0.18 11.1 21.9 0.28 10.4 21.9 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region TMEM65 PF10507.7 NM_175212.4_3 - 1.2e-45 153.8 3.5 1.9e-45 153.2 3.5 1.3 1 0 0 1 1 1 1 Transmembrane protein 65 NACHT PF05729.10 NM_178420.3_1 - 9.9e-21 74.2 0.0 2.3e-20 73.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain LRR_6 PF13516.4 NM_178420.3_1 - 6.6e-08 31.9 6.8 0.038 13.9 0.8 6.4 6 0 0 6 6 6 2 Leucine Rich repeat AAA_16 PF13191.4 NM_178420.3_1 - 0.016 15.5 0.1 0.065 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain DUF815 PF05673.11 NM_178420.3_1 - 0.043 12.8 0.0 0.072 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.4 NM_178420.3_1 - 0.11 12.7 0.0 0.51 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.15 NM_178420.3_1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Tissue_fac PF01108.15 NM_008348.3_3 - 1.4e-26 92.3 0.2 2.7e-26 91.3 0.2 1.5 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.8 NM_008348.3_3 - 0.0066 16.6 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III RRM_1 PF00076.20 NM_001290128.1_1 - 3.4e-17 61.9 0.0 8.2e-10 38.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 NM_001290128.1_1 - 1.9e-07 30.7 3.2 5.2e-07 29.3 3.2 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.4 NM_001290128.1_1 - 0.0043 16.9 0.3 0.0094 15.8 0.3 1.5 1 0 0 1 1 1 1 Zinc knuckle RRM_5 PF13893.4 NM_001290128.1_1 - 0.01 15.3 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_5 PF14787.4 NM_001290128.1_1 - 0.076 12.6 2.3 0.16 11.5 2.3 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.4 NM_001290128.1_1 - 0.48 10.2 7.4 0.17 11.6 3.8 2.1 2 0 0 2 2 2 0 Zinc knuckle Reprolysin PF01421.17 NM_145745.2_3 - 2.5e-46 158.0 3.8 2.5e-46 158.0 3.8 2.8 3 0 0 3 3 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_145745.2_3 - 5.6e-34 116.9 9.1 5.6e-34 116.9 9.1 4.1 3 2 1 4 4 1 1 ADAM cysteine-rich Disintegrin PF00200.21 NM_145745.2_3 - 4.8e-21 75.2 28.5 4.8e-21 75.2 28.5 4.7 4 1 0 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.17 NM_145745.2_3 - 5.9e-18 65.3 0.0 1.2e-17 64.4 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_145745.2_3 - 1.5e-14 54.5 3.9 4.1e-14 53.1 3.9 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 NM_145745.2_3 - 2.9e-11 43.8 0.2 5.4e-11 42.9 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_145745.2_3 - 1.2e-08 35.0 2.9 3.1e-08 33.6 2.9 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_145745.2_3 - 1.9e-07 30.8 0.2 3.2e-07 30.1 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 NM_145745.2_3 - 0.018 14.8 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Matrixin DUF4953 PF16313.3 NM_145745.2_3 - 0.049 12.7 0.1 0.08 12.0 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Gln-synt_N PF03951.17 NM_145745.2_3 - 0.058 13.0 0.0 0.19 11.4 0.0 1.8 2 0 0 2 2 2 0 Glutamine synthetase, beta-Grasp domain fn3 PF00041.19 NM_199312.3_1 - 0.17 12.2 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III domain PRY PF13765.4 NM_011280.2_3 - 1e-18 66.5 0.4 3.1e-18 65.0 0.4 1.9 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 NM_011280.2_3 - 4.3e-13 49.3 0.0 8.5e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 NM_011280.2_3 - 2.2e-10 40.4 11.2 2.2e-10 40.4 11.2 3.5 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 NM_011280.2_3 - 8.6e-09 35.3 1.4 8.6e-09 35.3 1.4 3.8 4 1 0 4 4 4 1 B-box zinc finger zf-RING_UBOX PF13445.4 NM_011280.2_3 - 8.9e-09 35.1 5.1 8.9e-09 35.1 5.1 3.5 3 1 1 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_011280.2_3 - 4.6e-08 32.7 9.0 4.6e-08 32.7 9.0 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_011280.2_3 - 6.2e-07 29.0 7.1 6.2e-07 29.0 7.1 3.9 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_011280.2_3 - 2.5e-06 27.1 9.1 2.5e-06 27.1 9.1 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_011280.2_3 - 1.2e-05 25.4 9.5 1.2e-05 25.4 9.5 3.2 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 NM_011280.2_3 - 0.00055 19.7 7.4 0.00055 19.7 7.4 3.6 3 2 0 3 3 3 1 zinc-RING finger domain STAT_alpha PF01017.18 NM_011280.2_3 - 0.0037 17.0 4.4 0.0068 16.1 4.4 1.4 1 0 0 1 1 1 1 STAT protein, all-alpha domain zf-Nse PF11789.6 NM_011280.2_3 - 0.024 14.3 4.9 0.068 12.9 4.9 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.4 NM_011280.2_3 - 1.4 8.6 14.4 0.75 9.4 9.1 3.3 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.5 NM_011280.2_3 - 2.9 8.1 15.7 0.032 14.4 3.5 3.6 4 0 0 4 4 4 0 RING-H2 zinc finger domain zf-RING_10 PF16685.3 NM_011280.2_3 - 4.8 7.3 10.7 0.19 11.7 3.0 2.7 3 0 0 3 3 2 0 zinc RING finger of MSL2 Rad50_zn_hook PF04423.12 NM_011280.2_3 - 7 6.4 8.3 4.2 7.1 0.8 3.1 3 0 0 3 3 3 0 Rad50 zinc hook motif Pkinase PF00069.23 NM_001080965.1_2 - 1.1e-72 244.5 0.0 1.3e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001080965.1_2 - 6e-45 153.4 0.0 7.6e-45 153.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001080965.1_2 - 1e-06 28.2 0.0 3.8e-06 26.3 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.12 NM_001080965.1_2 - 0.018 14.2 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 NM_001080965.1_2 - 0.045 13.2 0.7 2.5 7.5 0.1 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.21 NM_001080965.1_2 - 0.052 13.3 1.3 1.2 8.9 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.7 NM_001080965.1_2 - 0.087 12.2 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF4560 PF15118.4 NM_026050.2_1 - 1.7e-36 124.0 3.3 2.6e-36 123.3 3.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4560) FAM220 PF15487.4 NM_026050.2_2 - 9.7e-71 238.5 0.0 1.3e-70 238.1 0.0 1.2 1 0 0 1 1 1 1 FAM220 family TMEM151 PF14857.4 NM_001001885.1_1 - 2.5e-179 596.6 0.1 7.8e-177 588.3 0.1 2.1 1 1 0 1 1 1 1 TMEM151 family RnaseA PF00074.18 NM_001161731.2_1 - 4.7e-35 120.6 0.7 7.4e-35 120.0 0.7 1.3 1 0 0 1 1 1 1 Pancreatic ribonuclease ESP PF16590.3 NM_001177587.1_2 - 1.5e-30 105.1 0.3 2.6e-30 104.4 0.3 1.3 1 0 0 1 1 1 1 Exocrine gland-secreting peptide DUF3585 PF12130.6 NM_001114595.1_1 - 4.2e-40 136.9 26.8 4.2e-40 136.9 26.8 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3585) CH PF00307.29 NM_001114595.1_1 - 1.4e-21 76.6 0.0 2.8e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain NT-C2 PF10358.7 NM_001114595.1_1 - 6e-21 74.6 0.0 9.6e-21 73.9 0.0 1.3 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins CAMSAP_CH PF11971.6 NM_001114595.1_1 - 0.00027 20.6 0.0 0.00051 19.7 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain EPO_TPO PF00758.16 NM_001289894.1_1 - 3.4e-43 147.3 0.0 6.2e-43 146.5 0.0 1.4 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin P33MONOX PF15302.4 NM_001252647.1_1 - 7e-103 344.2 7.3 9.5e-103 343.8 7.3 1.1 1 0 0 1 1 1 1 P33 mono-oxygenase I-set PF07679.14 NM_182992.2_3 - 1e-104 342.7 0.0 1.6e-21 76.0 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_182992.2_3 - 5.7e-74 244.6 0.0 1.3e-14 54.5 0.0 6.0 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 NM_182992.2_3 - 2.9e-47 158.6 0.1 7.2e-11 42.0 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 NM_182992.2_3 - 2.3e-46 155.9 0.0 1.1e-08 35.1 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.15 NM_182992.2_3 - 7.9e-19 67.7 4.1 0.01 15.9 0.1 7.9 5 4 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_182992.2_3 - 8.7e-10 38.4 4.9 0.33 10.9 0.0 5.3 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_182992.2_3 - 2e-08 34.4 0.1 0.2 12.0 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin C1-set domain Receptor_2B4 PF11465.6 NM_182992.2_3 - 0.00013 21.9 0.0 0.72 10.0 0.0 4.4 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 Izumo-Ig PF16706.3 NM_182992.2_3 - 0.0018 18.1 0.0 23 5.0 0.0 3.6 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain BiPBP_C PF06832.10 NM_182992.2_3 - 0.014 15.3 0.0 2.7 7.9 0.0 3.7 4 0 0 4 4 4 0 Penicillin-Binding Protein C-terminus Family Neur_chan_LBD PF02931.21 NM_001081104.1_1 - 3.3e-67 225.9 1.1 4.3e-67 225.6 1.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_001081104.1_1 - 1.1e-48 166.3 0.3 1.4e-48 165.9 0.3 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region CENP-Q PF13094.4 NM_001168386.2_1 - 0.39 10.8 8.9 0.94 9.5 9.0 1.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit ATG16 PF08614.9 NM_001168386.2_1 - 0.47 10.5 19.3 2 8.4 7.1 3.1 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) EF-hand_1 PF00036.30 NM_001291442.1_1 - 1.1e-11 43.3 7.7 2.9e-05 23.2 0.1 3.9 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.4 NM_001291442.1_1 - 1.9e-11 42.8 6.9 4.8e-05 22.8 0.2 4.4 5 0 0 5 5 5 2 EF-hand domain EF-hand_7 PF13499.4 NM_001291442.1_1 - 3.3e-08 33.8 4.7 0.00078 19.7 0.4 3.2 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_001291442.1_1 - 9.8e-08 31.1 7.0 4.4e-06 25.8 1.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 NM_001291442.1_1 - 1.1e-07 31.4 5.7 5.5e-05 22.7 0.1 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.5 NM_001291442.1_1 - 0.00028 20.6 0.4 0.034 13.9 0.1 2.5 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Laminin_G_2 PF02210.22 NM_001289496.1_1 - 4.2e-82 272.8 0.4 1.1e-28 100.2 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.21 NM_001289496.1_1 - 7.5e-82 271.9 0.1 2e-26 92.6 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain fn3 PF00041.19 NM_001289496.1_1 - 7.2e-29 99.8 0.1 3.8e-14 52.7 0.0 2.6 2 0 0 2 2 2 2 Fibronectin type III domain Laminin_G_3 PF13385.4 NM_001289496.1_1 - 1.8e-11 44.3 0.2 0.028 14.4 0.0 3.3 3 0 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 NM_001289496.1_1 - 1.6e-07 31.4 20.9 1.8e-05 24.8 7.4 4.8 5 0 0 5 5 5 2 EGF-like domain Pur_ac_phosph_N PF16656.3 NM_001289496.1_1 - 1.9e-07 31.4 0.0 0.016 15.6 0.0 2.6 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain hEGF PF12661.5 NM_001289496.1_1 - 1.3e-05 25.6 18.8 0.0076 16.8 0.7 4.6 3 0 0 3 3 3 2 Human growth factor-like EGF Stirrup PF09061.4 NM_001289496.1_1 - 0.0016 18.4 0.1 2.5 8.2 0.0 3.3 3 0 0 3 3 3 1 Stirrup cEGF PF12662.5 NM_001289496.1_1 - 3.5 7.5 11.9 0.4 10.5 0.3 3.4 2 0 0 2 2 2 0 Complement Clr-like EGF-like WD40 PF00400.30 NM_001290522.1_1 - 5.1e-22 77.6 10.2 6.3e-06 26.7 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001290522.1_1 - 9.7e-07 28.9 0.0 0.087 13.0 0.0 3.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_001290522.1_1 - 5.4e-06 25.2 1.1 0.13 10.7 0.1 3.7 2 1 2 4 4 4 2 Nucleoporin Nup120/160 Reprolysin PF01421.17 NM_001310439.1_3 - 1.4e-62 211.0 0.1 1.4e-62 211.0 0.1 2.0 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 NM_001310439.1_3 - 7.4e-27 94.2 0.6 1.4e-26 93.3 0.6 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.10 NM_001310439.1_3 - 1.7e-25 89.6 7.6 1.7e-25 89.6 7.6 3.1 3 0 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 NM_001310439.1_3 - 5e-15 55.9 30.1 5e-15 55.9 30.1 4.8 5 0 0 5 5 5 1 Disintegrin Reprolysin_3 PF13582.4 NM_001310439.1_3 - 5.3e-09 36.5 0.0 1.2e-08 35.4 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.11 NM_001310439.1_3 - 2e-05 24.7 10.6 2e-05 24.7 10.6 5.3 4 1 0 4 4 4 1 EGF-like domain Reprolysin_2 PF13574.4 NM_001310439.1_3 - 0.016 15.0 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Ank_2 PF12796.5 NM_026256.2_2 - 1.3e-33 115.3 0.5 6e-12 45.9 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_026256.2_2 - 4.4e-30 103.5 2.1 1.6e-09 38.0 0.1 5.8 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_026256.2_2 - 6.1e-29 99.5 1.1 6.6e-13 48.5 0.0 4.0 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 NM_026256.2_2 - 1.4e-23 82.1 0.9 1.6e-05 25.0 0.0 6.2 7 0 0 7 7 7 4 Ankyrin repeat Ank_3 PF13606.4 NM_026256.2_2 - 1e-18 65.3 3.6 0.0021 18.3 0.0 6.5 7 0 0 7 7 7 3 Ankyrin repeat DUF4174 PF13778.4 NM_026439.2_1 - 2.6e-99 327.6 0.0 8.4e-33 113.2 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function (DUF4174) Zip PF02535.20 NM_026439.2_1 - 2.1 7.3 5.6 3.5 6.6 5.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.10 NM_026439.2_1 - 7.7 6.1 17.7 17 5.0 17.7 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PRY PF13765.4 NM_080510.2_3 - 2.2e-19 68.6 0.2 4.1e-19 67.8 0.2 1.5 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 NM_080510.2_3 - 1.6e-15 57.2 0.0 2.6e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 NM_080510.2_3 - 2.4e-12 46.7 8.8 2.4e-12 46.7 8.8 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 NM_080510.2_3 - 1.1e-10 41.0 8.3 5e-10 39.0 8.3 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_080510.2_3 - 8.9e-08 31.9 10.7 8.9e-08 31.9 10.7 2.4 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_080510.2_3 - 6.2e-07 29.0 11.5 6.2e-07 29.0 11.5 2.8 4 0 0 4 4 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_080510.2_3 - 2.5e-05 23.9 9.4 2.5e-05 23.9 9.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_080510.2_3 - 0.00012 22.1 11.5 0.00012 22.1 11.5 2.5 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_080510.2_3 - 0.00033 20.4 8.7 0.00033 20.4 8.7 2.9 2 1 0 2 2 2 1 zinc-RING finger domain zf-Nse PF11789.6 NM_080510.2_3 - 0.015 15.0 3.6 0.015 15.0 3.6 2.1 2 0 0 2 2 1 0 Zinc-finger of the MIZ type in Nse subunit TerY_C PF15616.4 NM_080510.2_3 - 0.12 12.4 8.1 0.87 9.6 4.4 2.5 1 1 1 2 2 2 0 TerY-C metal binding domain zf-RING_6 PF14835.4 NM_080510.2_3 - 0.14 11.9 6.9 0.53 10.1 6.9 2.0 1 1 0 1 1 1 0 zf-RING of BARD1-type protein DUF848 PF05852.9 NM_080510.2_3 - 0.16 12.0 5.7 0.27 11.2 5.7 1.3 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Gp-FAR-1 PF05823.10 NM_080510.2_3 - 0.18 12.0 6.9 0.16 12.2 3.0 2.1 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) zf-RING_10 PF16685.3 NM_080510.2_3 - 3 7.9 12.7 1.1 9.3 9.4 2.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 NM_080510.2_3 - 5.9 6.7 16.1 2.1 8.1 11.2 2.8 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 NM_080510.2_3 - 9.7 6.4 13.9 1.3e+02 2.9 13.9 2.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain LCE PF14672.4 NM_001018079.1_2 - 3.6e-29 101.1 44.2 3.6e-29 101.1 44.2 2.2 2 1 0 2 2 2 1 Late cornified envelope Ribosomal_L1 PF00687.19 NM_025546.2_2 - 2.9e-53 180.5 1.3 2.9e-53 180.5 1.3 1.9 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family DUF972 PF06156.11 NM_025546.2_2 - 0.82 10.2 4.9 0.89 10.1 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF972) 7tm_1 PF00001.19 NM_010332.2_2 - 1.1e-33 116.5 10.3 1.8e-33 115.8 10.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_010332.2_2 - 0.00035 19.9 8.7 0.014 14.7 0.3 2.8 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Kinetochor_Ybp2 PF08568.8 NM_001161738.1_2 - 2.4e-97 326.8 12.4 2.7e-97 326.6 12.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin Connexin PF00029.17 NM_001271623.1_2 - 1.4e-99 332.3 0.0 2.2e-99 331.7 0.0 1.3 1 0 0 1 1 1 1 Connexin 7tm_4 PF13853.4 NM_146441.1_1 - 3.6e-50 171.1 22.5 4.4e-50 170.8 22.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146441.1_1 - 6.8e-22 77.8 24.5 1.1e-21 77.1 24.5 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146441.1_1 - 0.00011 21.6 24.1 0.00028 20.2 23.9 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx RNase_HII PF01351.16 NM_027187.3_2 - 8.4e-51 172.5 0.0 1.1e-50 172.1 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII Ion_trans PF00520.29 NM_011706.2_1 - 9.5e-21 74.0 15.9 1.3e-20 73.6 15.9 1.1 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.5 NM_011706.2_1 - 2e-14 53.8 0.1 8.2e-07 29.4 0.0 3.6 2 2 0 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 NM_011706.2_1 - 5.9e-09 35.8 0.4 0.013 15.8 0.0 4.9 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.4 NM_011706.2_1 - 1.8e-08 34.4 0.1 0.25 11.7 0.0 4.1 3 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_011706.2_1 - 1.7e-07 30.8 0.8 0.028 14.8 0.1 5.1 5 0 0 5 5 5 1 Ankyrin repeat Ank_4 PF13637.4 NM_011706.2_1 - 8.1e-06 26.2 0.1 0.32 11.5 0.0 3.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Takusan PF04822.11 NM_027940.2_1 - 1.1e-18 66.8 7.7 2e-18 65.9 7.7 1.4 1 0 0 1 1 1 1 Takusan Serine_rich PF08824.8 NM_027940.2_1 - 2.1 8.2 7.4 2.1 8.2 2.4 2.1 1 1 1 2 2 2 0 Serine rich protein interaction domain PRKG1_interact PF15898.3 NM_027940.2_1 - 3.1 8.6 13.0 0.48 11.2 6.0 2.2 1 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain CsrA PF02599.14 NM_027940.2_3 - 0.054 13.3 0.1 0.089 12.6 0.1 1.3 1 0 0 1 1 1 0 Global regulator protein family SSP160 PF06933.9 NM_011751.3_3 - 0.15 10.1 7.0 0.2 9.7 7.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 zf-C2H2_4 PF13894.4 NM_011751.3_3 - 0.99 10.3 8.1 4.9 8.1 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger NCBP3 PF10309.7 NM_177464.4_2 - 0.00035 20.2 0.0 0.00068 19.3 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.9 NM_177464.4_2 - 0.012 15.5 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 RNA binding domain DUF4513 PF14983.4 NM_026099.3_2 - 4.8e-75 249.8 0.0 5.9e-75 249.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4513) MAGE PF01454.17 NM_031171.1_1 - 3e-18 66.2 0.0 4.5e-11 42.7 0.0 2.3 1 1 0 2 2 2 2 MAGE family MAGE_N PF12440.6 NM_031171.1_1 - 0.00029 21.3 5.7 0.00034 21.1 4.5 1.8 2 0 0 2 2 2 1 Melanoma associated antigen family N terminal Trypsin PF00089.24 NM_008555.2_2 - 5.2e-80 268.3 0.0 8.3e-80 267.6 0.0 1.3 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 NM_008555.2_2 - 5.8e-52 174.6 1.0 4.4e-31 107.3 0.1 2.5 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 NM_008555.2_2 - 2.8e-18 66.1 6.2 1.4e-09 38.2 0.4 2.9 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 NM_008555.2_2 - 6.2e-09 35.9 11.4 6.5e-08 32.6 9.0 3.0 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 NM_008555.2_2 - 3.2e-05 23.9 9.4 3.2e-05 23.9 9.4 3.7 4 0 0 4 4 4 1 Calcium-binding EGF domain Trypsin_2 PF13365.4 NM_008555.2_2 - 3.3e-05 24.7 0.0 7.1e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain CUB_2 PF02408.18 NM_008555.2_2 - 0.00013 21.5 0.5 0.51 10.0 0.2 2.9 3 0 0 3 3 3 2 CUB-like domain cEGF PF12662.5 NM_008555.2_2 - 0.00054 19.7 4.4 0.0044 16.8 3.8 2.8 2 0 0 2 2 2 1 Complement Clr-like EGF-like Peptidase_S6 PF02395.14 NM_008555.2_2 - 0.052 11.4 0.1 0.075 10.9 0.1 1.1 1 0 0 1 1 1 0 Immunoglobulin A1 protease DUF1986 PF09342.9 NM_008555.2_2 - 0.1 12.9 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Na_sulph_symp PF00939.17 NM_022411.3_1 - 5.5e-158 526.7 22.5 6.5e-158 526.5 22.5 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.14 NM_022411.3_1 - 3.2e-39 134.8 16.5 2.6e-22 79.3 0.0 3.1 2 1 1 3 3 3 3 Citrate transporter N_BRCA1_IG PF16158.3 NM_008676.3_3 - 1.7e-30 105.6 0.4 3.6e-30 104.6 0.4 1.6 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.22 NM_008676.3_3 - 8.4e-13 47.9 0.0 1.5e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 PB1 domain ZZ PF00569.15 NM_008676.3_3 - 5.4e-05 22.8 6.9 0.00013 21.6 6.9 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.14 NM_008676.3_3 - 0.099 12.8 5.3 0.25 11.6 5.3 1.7 1 0 0 1 1 1 0 C1 domain JmjC PF02373.20 NM_001033430.4_2 - 2.8e-10 40.5 1.9 1.4e-09 38.3 1.9 2.2 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.27 NM_001033430.4_2 - 1e-07 31.6 8.5 1e-07 31.6 8.5 2.4 2 0 0 2 2 2 1 PHD-finger Cupin_8 PF13621.4 NM_001033430.4_2 - 2.3e-07 30.7 0.1 6.2e-07 29.3 0.1 1.6 1 0 0 1 1 1 1 Cupin-like domain PHD_4 PF16866.3 NM_001033430.4_2 - 0.56 10.2 5.2 2.1 8.4 5.2 2.0 1 0 0 1 1 1 0 PHD-finger Rhomboid PF01694.20 NM_139228.3_1 - 2.7e-32 111.7 9.9 5.8e-32 110.6 9.9 1.6 1 0 0 1 1 1 1 Rhomboid family EF-hand_7 PF13499.4 NM_139228.3_1 - 0.00027 21.2 0.0 0.00041 20.6 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_139228.3_1 - 0.0012 18.1 0.0 1.7 8.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 NM_139228.3_1 - 0.0065 16.1 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_139228.3_1 - 0.029 14.2 0.0 3.3 7.7 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain EF-hand_11 PF08976.9 NM_139228.3_1 - 0.1 13.4 0.0 0.18 12.6 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain ANAPC15 PF15243.4 NM_001291348.1_1 - 8.1e-39 131.8 15.2 8.1e-39 131.8 15.2 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 15 RNA_pol_3_Rpc31 PF11705.6 NM_001291348.1_1 - 0.00014 22.0 9.5 0.00023 21.3 9.5 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Na_trans_assoc PF06512.11 NM_001291348.1_1 - 0.022 15.0 5.6 0.029 14.6 5.6 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated DUF4746 PF15928.3 NM_001291348.1_1 - 0.051 12.9 6.1 0.086 12.1 6.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Astro_capsid_p PF12226.6 NM_001291348.1_1 - 1.2 8.1 15.4 1.7 7.6 15.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.10 NM_001291348.1_1 - 1.9 6.5 18.9 2.4 6.1 18.9 1.0 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.7 NM_001291348.1_1 - 3.8 6.4 28.8 5.8 5.8 28.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RXT2_N PF08595.9 NM_001291348.1_1 - 6.3 6.7 12.2 11 5.9 12.2 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal CDC45 PF02724.12 NM_001291348.1_1 - 7.5 4.6 16.7 9.9 4.2 16.7 1.0 1 0 0 1 1 1 0 CDC45-like protein SOUL PF04832.10 NM_013546.3_2 - 3.7e-37 127.9 0.0 4.5e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 SOUL heme-binding protein Chlam_OMP PF01308.15 NM_001310731.1_1 - 0.58 8.7 1.9 0.83 8.2 1.9 1.1 1 0 0 1 1 1 0 Chlamydia major outer membrane protein RNF220 PF15926.3 NM_001310731.1_3 - 2.9e-48 164.6 14.1 4e-47 160.8 0.2 2.7 2 1 1 3 3 3 2 E3 ubiquitin-protein ligase RNF220 zf-C3HC4_2 PF13923.4 NM_001310731.1_3 - 2.8e-14 52.5 11.1 9.6e-14 50.8 11.1 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001310731.1_3 - 3.2e-05 23.6 7.6 0.00013 21.6 7.6 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001310731.1_3 - 0.00026 20.7 7.8 0.00082 19.2 7.8 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.23 NM_001310731.1_3 - 0.0012 18.5 9.8 0.0012 18.5 9.8 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001310731.1_3 - 0.0027 17.8 10.6 0.0027 17.8 10.6 2.6 4 0 0 4 4 4 1 Ring finger domain zf-RING_UBOX PF13445.4 NM_001310731.1_3 - 0.0076 16.1 5.8 0.029 14.2 5.8 2.1 1 0 0 1 1 1 1 RING-type zinc-finger Pox_A_type_inc PF04508.10 NM_001310731.1_3 - 0.047 13.4 0.4 0.1 12.4 0.4 1.5 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Prok-RING_4 PF14447.4 NM_001310731.1_3 - 0.14 11.9 6.5 0.43 10.4 6.5 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DCR PF14047.4 NM_001018002.1_3 - 4.8e-38 129.0 1.1 1e-37 128.0 1.1 1.6 1 0 0 1 1 1 1 Dppa2/4 conserved region Dppa2_A PF14049.4 NM_001018002.1_3 - 5.7e-06 26.3 13.7 6.5e-06 26.1 1.3 3.3 3 0 0 3 3 3 2 Dppa2/4 conserved region in higher vertebrates 7tm_1 PF00001.19 NM_010287.3_1 - 7.1e-50 169.6 24.0 1e-49 169.1 24.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_010287.3_1 - 1.2e-13 51.0 22.7 1.5e-13 50.6 22.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_010287.3_1 - 3.4e-06 26.9 9.4 5.4e-06 26.2 9.4 1.3 1 0 0 1 1 1 1 Olfactory receptor Chibby PF14645.4 NM_001164139.1_1 - 4.2e-13 49.6 23.9 1.4e-11 44.7 0.7 4.4 2 2 0 2 2 2 1 Chibby family ZapB PF06005.10 NM_001164139.1_1 - 0.011 16.1 4.8 0.011 16.1 4.8 3.9 3 1 0 3 3 3 0 Cell division protein ZapB bZIP_2 PF07716.13 NM_001164139.1_1 - 0.015 15.2 8.3 0.015 15.2 8.3 3.9 3 0 0 3 3 3 0 Basic region leucine zipper ABATE PF07336.9 NM_001164139.1_1 - 0.47 11.0 5.8 0.33 11.5 0.3 2.4 1 1 1 2 2 2 0 Putative stress-induced transcription regulator Latarcin PF10279.7 NM_001164139.1_1 - 2.6 8.4 9.2 0.11 12.8 0.5 2.6 1 1 1 2 2 2 0 Latarcin precursor FBA PF04300.11 NM_207238.3_1 - 1.5e-67 226.8 0.0 2.1e-67 226.3 0.0 1.1 1 0 0 1 1 1 1 F-box associated region F-box PF00646.31 NM_207238.3_1 - 2.6e-11 43.0 4.2 5.5e-11 41.9 4.2 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 NM_207238.3_1 - 9.6e-10 38.1 4.2 2.4e-09 36.8 4.2 1.7 1 0 0 1 1 1 1 F-box-like DnaJ PF00226.29 NM_008299.3_2 - 8.7e-28 96.1 1.8 1.3e-27 95.5 1.8 1.3 1 0 0 1 1 1 1 DnaJ domain VirB3 PF05101.11 NM_008299.3_2 - 0.43 10.7 1.8 0.96 9.6 1.8 1.5 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein FH2 PF02181.21 NM_172409.2_3 - 1.6e-104 349.8 13.1 1.6e-104 349.8 13.1 2.7 3 0 0 3 3 3 2 Formin Homology 2 Domain Drf_FH3 PF06367.14 NM_172409.2_3 - 2.4e-48 164.2 16.6 2.4e-48 164.2 16.6 2.1 2 0 0 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.11 NM_172409.2_3 - 2.9e-25 88.8 2.1 3.5e-13 49.4 0.0 5.0 4 1 1 5 5 5 2 Diaphanous GTPase-binding Domain DUF1664 PF07889.10 NM_172409.2_3 - 3.5 7.5 11.3 17 5.3 11.3 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) 7tm_4 PF13853.4 NM_001011750.2_1 - 1.3e-37 129.9 21.3 1.6e-37 129.6 21.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011750.2_1 - 5.3e-22 78.2 24.2 1.9e-21 76.3 24.2 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) G-alpha PF00503.18 NM_201616.2_2 - 2.7e-105 352.3 0.1 4.2e-105 351.7 0.1 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 NM_201616.2_2 - 5.4e-16 58.4 2.7 3.6e-13 49.2 0.5 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_201616.2_2 - 0.0001 21.6 2.7 0.0018 17.6 0.2 2.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.11 NM_201616.2_2 - 0.00051 20.1 1.4 0.11 12.6 0.2 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.25 NM_201616.2_2 - 0.079 12.4 0.2 0.71 9.2 0.0 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.4 NM_201616.2_2 - 0.094 12.3 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF563 PF04577.12 NM_175313.4_2 - 5.8e-28 98.3 0.2 8.4e-28 97.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) 7tm_4 PF13853.4 NM_146938.1_1 - 9.2e-58 196.0 23.3 1.1e-57 195.8 23.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146938.1_1 - 6.9e-24 84.4 23.9 3.8e-23 82.0 23.9 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TFR_dimer PF04253.13 NM_028279.3_1 - 7.8e-33 113.0 0.0 1.4e-32 112.1 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.15 NM_028279.3_1 - 1.3e-19 70.5 0.0 2.7e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.20 NM_028279.3_1 - 1.3e-11 44.3 0.0 3.1e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 PA domain PPR_3 PF13812.4 NM_028279.3_1 - 0.065 13.2 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 Pentatricopeptide repeat domain Thioredoxin PF00085.18 NM_024181.2_2 - 4.3e-90 296.4 0.1 1.8e-23 82.3 0.2 5.8 6 0 0 6 6 6 4 Thioredoxin DnaJ PF00226.29 NM_024181.2_2 - 1.6e-23 82.4 0.4 3.3e-23 81.4 0.4 1.6 1 0 0 1 1 1 1 DnaJ domain Thioredoxin_2 PF13098.4 NM_024181.2_2 - 1.8e-13 50.8 3.3 0.00038 20.7 0.0 5.8 4 3 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_6 PF13848.4 NM_024181.2_2 - 1.2e-12 48.0 0.0 0.0002 21.3 0.0 4.1 3 1 1 4 4 4 3 Thioredoxin-like domain Thioredoxin_8 PF13905.4 NM_024181.2_2 - 3.2e-12 46.5 1.4 0.19 11.9 0.0 6.2 4 2 2 6 6 6 4 Thioredoxin-like OST3_OST6 PF04756.11 NM_024181.2_2 - 1.7e-10 40.6 0.3 0.015 14.6 0.0 4.1 3 1 1 4 4 4 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.4 NM_024181.2_2 - 2e-07 30.9 1.9 2.1 8.5 0.1 4.6 4 0 0 4 4 4 3 Thioredoxin-like Redoxin PF08534.8 NM_024181.2_2 - 1.3e-05 24.8 0.6 0.29 10.6 0.0 3.3 4 0 0 4 4 4 2 Redoxin AhpC-TSA PF00578.19 NM_024181.2_2 - 1.4e-05 24.9 1.1 2.7 7.8 0.0 4.6 4 0 0 4 4 4 2 AhpC/TSA family Thioredoxin_9 PF14595.4 NM_024181.2_2 - 0.0028 17.3 2.5 4.2 7.0 0.0 3.4 2 1 0 3 3 3 1 Thioredoxin TraF PF13728.4 NM_024181.2_2 - 0.0087 15.8 0.3 1.1 8.9 0.0 3.0 3 0 0 3 3 3 1 F plasmid transfer operon protein HyaE PF07449.9 NM_024181.2_2 - 0.044 13.6 0.0 6.6 6.6 0.0 2.6 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE RMMBL PF07521.10 NM_024181.2_2 - 0.094 12.5 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Calsequestrin PF01216.15 NM_024181.2_2 - 0.13 11.1 0.0 18 4.1 0.0 2.6 3 0 0 3 3 3 0 Calsequestrin Neuregulin PF02158.13 NM_026333.4_2 - 0.0054 16.1 0.0 0.0082 15.5 0.0 1.3 1 0 0 1 1 1 1 Neuregulin family TMEM154 PF15102.4 NM_026333.4_2 - 0.04 13.7 0.0 0.04 13.7 0.0 1.5 2 0 0 2 2 2 0 TMEM154 protein family Scramblase PF03803.13 NM_008880.3_1 - 3.4e-90 301.0 0.0 4.4e-90 300.7 0.0 1.1 1 0 0 1 1 1 1 Scramblase Molybdopterin PF00384.20 NM_145518.2_3 - 4.3e-75 253.2 0.0 1.7e-74 251.2 0.0 1.8 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.4 NM_145518.2_3 - 1.6e-17 63.2 0.4 3.4e-17 62.1 0.4 1.6 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.7 NM_145518.2_3 - 3.9e-17 61.4 0.1 9.2e-17 60.2 0.1 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.9 NM_145518.2_3 - 5.7e-17 62.0 0.1 1.1e-16 61.1 0.1 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.25 NM_145518.2_3 - 2.3e-09 37.0 1.1 2.3e-09 37.0 1.1 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.20 NM_145518.2_3 - 0.048 13.3 0.1 7.7 6.2 0.0 2.5 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain BTB PF00651.29 NM_027947.2_1 - 1e-26 93.2 0.0 1.9e-26 92.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 NM_027947.2_1 - 3.5e-09 36.6 16.5 7.7e-06 26.0 0.5 4.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 NM_027947.2_1 - 0.012 15.9 3.3 0.012 15.9 3.3 5.6 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_027947.2_1 - 0.64 9.9 11.8 0.75 9.7 1.6 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger TCL1_MTCP1 PF01840.15 NM_013774.2_1 - 3.7e-40 136.0 0.0 5.4e-40 135.5 0.0 1.3 1 0 0 1 1 1 1 TCL1/MTCP1 family Aldedh PF00171.20 NM_001177438.1_3 - 2e-85 286.9 0.0 2.5e-85 286.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pyridoxal_deC PF00282.17 NM_001316673.1_1 - 9.4e-18 63.9 0.0 1.7e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 NM_001316673.1_1 - 1.3e-13 50.5 0.0 3.2e-13 49.2 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.19 NM_001316673.1_1 - 7.4e-08 31.8 0.0 1.4e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.15 NM_001316673.1_1 - 0.0024 17.1 0.0 0.0039 16.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SepSecS PF05889.11 NM_001316673.1_1 - 0.019 13.5 0.0 0.031 12.8 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.19 NM_001316673.1_1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase CENP-H PF05837.10 NM_021886.1_2 - 4.2e-25 88.2 13.7 4.2e-25 88.2 13.7 2.2 2 0 0 2 2 2 1 Centromere protein H (CENP-H) TSC21 PF15217.4 NM_028825.3_3 - 5.9e-103 342.2 5.8 7.2e-103 342.0 5.8 1.1 1 0 0 1 1 1 1 TSC21 family AMP-binding PF00501.26 NM_054094.5_1 - 1.4e-69 234.7 0.0 1.8e-69 234.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 NM_054094.5_1 - 3.6e-23 82.2 2.6 1e-22 80.7 1.2 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain SRI PF08236.9 NM_054094.5_1 - 0.014 15.4 0.2 0.026 14.6 0.2 1.3 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain Arm PF00514.21 NM_001040690.2_1 - 7.6e-32 108.2 17.3 1e-07 31.6 0.1 8.0 8 1 1 9 9 9 4 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.12 NM_001040690.2_1 - 8.1e-05 21.9 2.8 0.033 13.4 0.2 3.7 1 1 1 2 2 2 2 V-ATPase subunit H HEAT_EZ PF13513.4 NM_001040690.2_1 - 0.00028 21.1 8.6 0.032 14.6 0.0 4.6 5 1 1 6 6 6 2 HEAT-like repeat HEAT PF02985.20 NM_001040690.2_1 - 0.0013 18.7 0.7 1.5 9.1 0.0 3.7 3 0 0 3 3 3 2 HEAT repeat Cnd1 PF12717.5 NM_001040690.2_1 - 0.0072 16.2 8.9 1.7 8.5 0.5 4.3 2 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.6 NM_001040690.2_1 - 0.048 13.7 4.5 63 3.6 0.0 4.6 4 1 0 4 4 4 0 V-ATPase subunit H Nitr_red_bet_C PF14711.4 NM_001040690.2_1 - 0.051 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Respiratory nitrate reductase beta C-terminal Atx10homo_assoc PF09759.7 NM_001040690.2_1 - 0.13 12.2 0.6 27 4.8 0.1 3.4 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain DUF3719 PF12516.6 NM_001177633.1_1 - 5.9e-26 89.8 1.0 1.7e-25 88.4 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3719) AbbA_antirepres PF14156.4 NM_001177633.1_1 - 0.032 14.0 0.4 0.065 13.0 0.4 1.5 1 0 0 1 1 1 0 Antirepressor AbbA SOBP PF15279.4 NM_175407.3_1 - 2.5e-90 304.2 36.6 2.5e-90 304.2 36.6 3.9 4 1 1 5 5 5 1 Sine oculis-binding protein zf-FCS PF06467.12 NM_175407.3_1 - 0.00021 21.1 9.4 0.033 14.0 1.3 2.9 2 0 0 2 2 2 2 MYM-type Zinc finger with FCS sequence motif zf-C6H2 PF15801.3 NM_175407.3_1 - 7.7 6.8 10.7 0.79 10.0 1.8 3.4 3 0 0 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding MFS_1 PF07690.14 NM_001276383.1_3 - 6.3e-33 114.0 26.7 6.3e-33 114.0 26.7 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_001276383.1_3 - 3.3e-13 49.2 6.0 3.3e-13 49.2 6.0 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.18 NM_001276383.1_3 - 5.2e-11 41.4 18.9 8e-06 24.3 1.4 4.1 2 2 2 4 4 4 4 Organic Anion Transporter Polypeptide (OATP) family DENN PF02141.19 NM_001311139.1_1 - 1.2e-60 204.5 4.5 2.5e-60 203.5 4.5 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain RUN PF02759.17 NM_001311139.1_1 - 1.1e-36 125.6 5.2 1.9e-18 66.6 2.4 2.7 2 0 0 2 2 2 2 RUN domain dDENN PF03455.17 NM_001311139.1_1 - 3.1e-19 68.5 2.0 3.1e-19 68.5 2.0 2.4 3 0 0 3 3 3 1 dDENN domain uDENN PF03456.16 NM_001311139.1_1 - 4.7e-14 52.8 0.0 4.7e-14 52.8 0.0 2.2 3 0 0 3 3 3 1 uDENN domain PLAT PF01477.21 NM_001311139.1_1 - 1.1e-13 51.7 0.0 3.4e-13 50.0 0.0 1.9 2 0 0 2 2 2 1 PLAT/LH2 domain Gly_kinase PF02595.13 NM_001311139.1_1 - 0.16 10.8 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Glycerate kinase family CARMIL_C PF16000.3 NM_026825.3_2 - 2.2e-100 336.1 12.4 2.2e-100 336.1 12.4 2.1 2 0 0 2 2 2 1 CARMIL C-terminus LRR_6 PF13516.4 NM_026825.3_2 - 6.1e-10 38.2 26.2 0.0013 18.5 0.1 8.2 9 0 0 9 9 9 4 Leucine Rich repeat LRR_4 PF12799.5 NM_026825.3_2 - 0.00099 19.3 24.6 1.9 8.9 0.3 6.7 3 2 5 8 8 8 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_026825.3_2 - 0.013 15.7 13.6 45 5.0 0.1 8.1 6 1 1 7 7 7 0 Leucine Rich Repeat IL34 PF15036.4 NM_026825.3_2 - 0.064 13.2 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 Interleukin 34 Muted PF14942.4 NM_026825.3_2 - 0.56 10.4 6.3 2.4 8.3 0.4 3.3 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein zf-H2C2_2 PF13465.4 NM_173387.3_3 - 6.7e-104 335.9 81.7 4.5e-09 36.2 0.1 13.6 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_173387.3_3 - 5.5e-68 221.7 106.6 2.1e-06 27.8 1.0 13.6 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_173387.3_3 - 2e-39 130.7 103.4 0.0021 18.6 0.8 13.7 13 0 0 13 13 13 12 C2H2-type zinc finger KRAB PF01352.25 NM_173387.3_3 - 1.3e-25 88.7 0.1 2.7e-25 87.6 0.1 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_173387.3_3 - 1.3e-23 82.3 86.8 0.00087 19.1 0.2 13.5 13 0 0 13 13 13 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_173387.3_3 - 1.4e-15 57.0 54.8 0.0068 16.4 1.2 9.5 4 2 6 11 11 11 10 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_173387.3_3 - 9e-14 51.2 58.8 0.0017 18.5 0.2 12.3 12 0 0 12 12 12 6 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_173387.3_3 - 2.9e-07 31.0 50.2 0.28 11.8 0.7 6.9 1 1 7 8 8 8 6 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_173387.3_3 - 2.5e-06 27.0 89.6 0.0095 15.5 1.5 12.9 13 0 0 13 13 13 6 zinc-finger C2H2-type XPA_N PF01286.16 NM_173387.3_3 - 1.7e-05 24.6 53.0 2.1 8.3 0.2 12.5 13 0 0 13 13 13 2 XPA protein N-terminal DUF3268 PF11672.6 NM_173387.3_3 - 0.00012 22.3 40.2 0.028 14.6 0.6 6.6 5 2 1 7 7 7 3 zinc-finger-containing domain FYVE PF01363.19 NM_173387.3_3 - 0.0019 18.2 68.8 0.23 11.5 7.2 8.0 1 1 4 5 5 5 2 FYVE zinc finger zf-trcl PF13451.4 NM_173387.3_3 - 0.018 14.8 56.2 0.43 10.4 0.1 12.0 10 3 0 10 10 10 0 Probable zinc-ribbon domain zf-met PF12874.5 NM_173387.3_3 - 0.06 13.6 87.6 0.87 9.9 0.8 11.7 12 0 0 12 12 11 0 Zinc-finger of C2H2 type BolA PF01722.16 NM_173387.3_3 - 3.1 8.0 30.2 12 6.1 0.2 7.0 4 2 5 9 9 9 0 BolA-like protein Zn_Tnp_IS1595 PF12760.5 NM_173387.3_3 - 3.8 7.4 68.4 0.74 9.7 1.3 9.1 5 1 2 8 8 8 0 Transposase zinc-ribbon domain Dpy-30 PF05186.11 NM_030187.1_1 - 5.9e-21 73.8 0.3 2.6e-20 71.7 0.2 2.0 2 0 0 2 2 2 1 Dpy-30 motif ADK PF00406.20 NM_030187.1_1 - 1.7e-11 44.3 0.2 3.3e-07 30.4 0.4 3.0 2 1 0 2 2 2 2 Adenylate kinase AAA_18 PF13238.4 NM_030187.1_1 - 1.7e-05 25.2 0.4 8.1e-05 23.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.4 NM_030187.1_1 - 3.7e-05 24.0 12.6 5.5e-05 23.5 1.3 3.6 3 1 0 3 3 3 1 AAA domain Hydin_ADK PF17213.1 NM_030187.1_1 - 0.00063 20.0 1.6 0.0021 18.3 0.0 2.4 2 0 0 2 2 2 1 Hydin Adenylate kinase-like domain AAA_16 PF13191.4 NM_030187.1_1 - 0.023 14.9 1.4 0.047 13.9 0.0 2.2 1 1 1 2 2 2 0 AAA ATPase domain 6PF2K PF01591.16 NM_030187.1_1 - 0.029 13.6 0.0 0.075 12.2 0.0 1.7 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_28 PF13521.4 NM_030187.1_1 - 0.04 14.0 0.0 0.14 12.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.21 NM_030187.1_1 - 0.051 13.5 0.0 1.9 8.5 0.0 3.1 3 0 0 3 3 3 0 50S ribosome-binding GTPase RIIa PF02197.15 NM_030187.1_1 - 0.078 12.5 0.2 0.29 10.7 0.0 2.0 2 0 0 2 2 2 0 Regulatory subunit of type II PKA R-subunit GBP_C PF02841.12 NM_030187.1_1 - 3.2 6.9 21.5 1.8 7.8 11.1 2.4 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Ead_Ea22 PF13935.4 NM_030187.1_1 - 6.2 7.3 12.0 0.56 10.7 3.8 2.7 2 0 0 2 2 2 0 Ead/Ea22-like protein zf-TRAF PF02176.16 NM_009424.3_1 - 9e-19 67.8 4.5 9e-19 67.8 4.5 4.2 3 1 1 4 4 3 3 TRAF-type zinc finger zf-C3HC4_2 PF13923.4 NM_009424.3_1 - 3.5e-09 36.2 5.8 3.5e-09 36.2 5.8 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_009424.3_1 - 8e-08 31.9 5.6 8e-08 31.9 5.6 3.2 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_009424.3_1 - 1e-06 28.3 4.7 1e-06 28.3 4.7 4.2 4 1 1 5 5 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_009424.3_1 - 1.2e-06 28.5 4.7 1.2e-06 28.5 4.7 3.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.4 NM_009424.3_1 - 3.3e-06 26.9 6.2 3.3e-06 26.9 6.2 3.0 3 0 0 3 3 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 NM_009424.3_1 - 2.3e-05 24.3 4.2 2.3e-05 24.3 4.2 3.5 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING SlyX PF04102.10 NM_009424.3_1 - 0.00025 21.5 3.1 0.00058 20.3 3.1 1.6 1 0 0 1 1 1 1 SlyX zf-RING_5 PF14634.4 NM_009424.3_1 - 0.00033 20.4 4.6 0.00033 20.4 4.6 4.1 3 1 1 4 4 3 1 zinc-RING finger domain zf-TRAF_2 PF15965.3 NM_009424.3_1 - 0.00037 20.8 4.0 0.00037 20.8 4.0 3.7 3 1 1 4 4 2 1 TRAF-like zinc-finger Tropomyosin_1 PF12718.5 NM_009424.3_1 - 0.004 17.1 0.1 0.0068 16.4 0.1 1.2 1 0 0 1 1 1 1 Tropomyosin like DUF4455 PF14643.4 NM_009424.3_1 - 0.024 13.3 0.2 0.033 12.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) PspA_IM30 PF04012.10 NM_009424.3_1 - 0.038 13.5 2.0 0.056 12.9 2.0 1.1 1 0 0 1 1 1 0 PspA/IM30 family Sina PF03145.14 NM_009424.3_1 - 0.051 13.4 22.0 0.16 11.8 6.8 3.4 1 1 1 3 3 3 0 Seven in absentia protein family zf-RING_11 PF17123.3 NM_009424.3_1 - 0.08 12.5 3.6 0.29 10.8 3.6 2.1 1 0 0 1 1 1 0 RING-like zinc finger DUF16 PF01519.14 NM_009424.3_1 - 0.14 12.5 0.1 0.33 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 Tropomyosin PF00261.18 NM_009424.3_1 - 0.19 10.9 2.7 0.29 10.3 2.7 1.1 1 0 0 1 1 1 0 Tropomyosin PKcGMP_CC PF16808.3 NM_009424.3_1 - 3.3 7.5 5.2 0.88 9.3 1.3 2.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HECT PF00632.23 NM_001081359.3_1 - 2.2e-65 221.1 0.0 3.5e-65 220.4 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) E3_UbLigase_EDD PF11547.6 NM_001081359.3_1 - 8.2e-31 105.3 4.1 1.9e-30 104.2 4.1 1.7 1 0 0 1 1 1 1 E3 ubiquitin ligase EDD PABP PF00658.16 NM_001081359.3_1 - 4.9e-20 71.4 0.0 1e-19 70.4 0.0 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain PH PF00169.27 NM_013746.3_3 - 8.2e-08 32.6 0.0 1.3e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_013746.3_3 - 4.4e-05 23.7 0.2 9.7e-05 22.6 0.2 1.5 1 1 0 1 1 1 1 Pleckstrin homology domain TNFR_c6 PF00020.16 NM_008764.3_1 - 9.7e-24 83.4 31.2 3.8e-08 33.5 11.1 4.8 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Death PF00531.20 NM_008764.3_1 - 2e-16 59.8 5.2 1.3e-12 47.6 0.4 2.4 1 1 1 2 2 2 2 Death domain TC1 PF15063.4 NM_026931.2_3 - 1.3e-35 120.9 0.2 2.4e-35 120.1 0.2 1.4 1 0 0 1 1 1 1 Thyroid cancer protein 1 Ras PF00071.20 NM_008999.4_1 - 3.8e-51 172.8 0.7 5.2e-51 172.3 0.7 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_008999.4_1 - 7.7e-31 106.7 0.2 1.1e-30 106.2 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_008999.4_1 - 2.9e-08 33.2 0.3 4.4e-08 32.6 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_008999.4_1 - 8.9e-05 22.4 0.0 0.00014 21.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_008999.4_1 - 0.0015 18.3 0.3 0.16 11.7 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_008999.4_1 - 0.017 14.6 0.1 0.026 13.9 0.1 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 NM_008999.4_1 - 0.025 13.8 0.1 0.037 13.3 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Rho_GDI PF02115.15 NM_133796.7_2 - 2.2e-80 268.8 0.3 3e-80 268.4 0.3 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor PMP22_Claudin PF00822.18 NM_013805.4_3 - 7e-28 97.4 10.7 9e-28 97.1 10.7 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_013805.4_3 - 1.2e-08 34.8 14.5 1.7e-08 34.4 13.8 1.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Clc-like PF07062.10 NM_013805.4_3 - 0.0097 15.3 2.5 0.0097 15.3 2.5 1.8 1 1 0 2 2 2 1 Clc-like PHF5 PF03660.12 NM_026737.3_2 - 5.2e-48 161.4 13.9 5.2e-48 161.4 13.9 1.7 2 0 0 2 2 2 1 PHF5-like protein PolC_DP2 PF03833.11 NM_026737.3_2 - 1.4 6.5 8.2 1.9 6.1 8.2 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Fringe PF02434.14 NM_008494.3_1 - 4.8e-120 399.5 0.0 5.9e-120 399.3 0.0 1.1 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.19 NM_008494.3_1 - 0.041 13.6 0.0 0.065 12.9 0.0 1.2 1 0 0 1 1 1 0 Galactosyltransferase Fur_reg_FbpA PF13076.4 NM_008494.3_1 - 0.042 13.4 0.0 0.21 11.2 0.0 1.9 2 0 0 2 2 2 0 Fur-regulated basic protein A Ras PF00071.20 NM_019662.2_3 - 3.1e-26 91.8 0.0 4.2e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_019662.2_3 - 9.1e-05 22.6 0.0 0.00016 21.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_019662.2_3 - 0.0051 17.1 1.5 0.21 11.8 0.1 2.3 2 0 0 2 2 2 1 AAA ATPase domain FeoB_N PF02421.16 NM_019662.2_3 - 0.0092 15.4 0.0 0.18 11.2 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.14 NM_019662.2_3 - 0.038 13.7 0.0 3.9 7.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA PF00004.27 NM_019662.2_3 - 0.11 12.8 0.2 0.44 10.8 0.2 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.19 NM_019662.2_3 - 0.11 11.7 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 NM_019662.2_3 - 0.15 11.9 0.3 0.29 11.0 0.3 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RAWUL PF16207.3 NM_197992.1_3 - 6.6e-14 52.2 0.5 1.9e-13 50.7 0.5 1.8 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 NM_197992.1_3 - 2.5e-09 36.7 13.4 3.5e-09 36.2 12.7 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_197992.1_3 - 1.2e-08 34.6 13.4 3e-08 33.3 13.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_197992.1_3 - 3e-06 27.3 12.0 5.1e-06 26.5 11.2 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.4 NM_197992.1_3 - 1.5e-05 24.6 11.8 3.1e-05 23.6 11.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_197992.1_3 - 3.9e-05 23.7 7.2 8.7e-05 22.6 7.2 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain Rad60-SLD PF11976.6 NM_197992.1_3 - 0.001 18.7 0.3 0.0041 16.8 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like zf-RING_5 PF14634.4 NM_197992.1_3 - 0.0013 18.5 15.6 0.0062 16.3 14.8 2.3 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_197992.1_3 - 0.0016 18.3 9.0 0.0016 18.3 9.0 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-Nse PF11789.6 NM_197992.1_3 - 0.0095 15.6 6.9 0.019 14.6 6.9 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Atg8 PF02991.14 NM_197992.1_3 - 0.012 15.7 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like zf-ANAPC11 PF12861.5 NM_197992.1_3 - 0.035 14.0 3.8 0.063 13.2 3.8 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 NM_197992.1_3 - 0.067 13.2 13.8 0.16 12.0 13.8 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.4 NM_197992.1_3 - 0.16 11.7 15.0 0.3 10.8 13.4 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 NM_197992.1_3 - 0.48 10.5 10.8 0.27 11.2 8.2 2.0 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-RING_6 PF14835.4 NM_197992.1_3 - 3.1 7.6 8.9 0.23 11.2 3.9 1.7 2 0 0 2 2 2 0 zf-RING of BARD1-type protein fn3 PF00041.19 NM_001289498.1_1 - 1.8e-18 66.6 0.2 1.2e-11 44.6 0.0 2.4 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_001289498.1_1 - 0.002 18.5 0.0 0.016 15.6 0.0 2.2 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Laminin_G_2 PF02210.22 NM_001289498.1_2 - 4.3e-82 272.8 0.4 1.1e-28 100.2 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.21 NM_001289498.1_2 - 7.7e-82 271.9 0.1 2e-26 92.6 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_3 PF13385.4 NM_001289498.1_2 - 1.9e-11 44.2 0.2 0.028 14.4 0.0 3.3 3 0 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 NM_001289498.1_2 - 1.6e-07 31.4 20.9 1.8e-05 24.8 7.4 5.1 5 0 0 5 5 5 2 EGF-like domain hEGF PF12661.5 NM_001289498.1_2 - 0.00011 22.6 22.6 0.0076 16.8 0.7 5.1 4 0 0 4 4 4 2 Human growth factor-like EGF fn3 PF00041.19 NM_001289498.1_2 - 0.00018 21.7 0.0 0.00044 20.4 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Stirrup PF09061.4 NM_001289498.1_2 - 0.0017 18.4 0.1 2.5 8.2 0.0 3.3 3 0 0 3 3 3 1 Stirrup cEGF PF12662.5 NM_001289498.1_2 - 3.1 7.7 11.9 0.39 10.5 0.3 3.5 2 0 0 2 2 2 0 Complement Clr-like EGF-like RRM_1 PF00076.20 NM_008774.3_3 - 1.2e-91 300.4 1.9 8.8e-25 86.2 0.2 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.16 NM_008774.3_3 - 2.4e-32 110.8 0.7 1.5e-31 108.3 0.2 2.5 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.4 NM_008774.3_3 - 8.1e-09 35.0 0.1 0.16 11.4 0.1 4.2 1 1 2 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 NM_008774.3_3 - 1e-05 25.4 1.1 3.4 7.7 0.0 4.3 4 0 0 4 4 4 2 Limkain b1 Nup35_RRM_2 PF14605.4 NM_008774.3_3 - 1.5e-05 24.8 0.2 6.3 6.7 0.0 4.4 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif SET_assoc PF11767.6 NM_008774.3_3 - 4.7e-05 22.8 0.5 8.3 6.0 0.1 4.3 4 0 0 4 4 4 2 Histone lysine methyltransferase SET associated RRM_7 PF16367.3 NM_008774.3_3 - 0.00028 20.8 0.2 13 5.9 0.0 4.7 3 1 1 4 4 4 1 RNA recognition motif RRM_occluded PF16842.3 NM_008774.3_3 - 0.0009 18.9 0.0 0.5 10.1 0.0 3.5 3 0 0 3 3 3 1 Occluded RNA-recognition motif ATP-grasp_2 PF08442.8 NM_008774.3_3 - 0.0065 15.9 0.1 2.5 7.5 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain RRM_3 PF08777.9 NM_008774.3_3 - 0.01 15.7 10.1 0.49 10.3 1.0 3.9 5 0 0 5 5 5 0 RNA binding motif OB_RNB PF08206.9 NM_008774.3_3 - 0.069 12.7 3.0 6.5 6.4 0.1 3.3 3 0 0 3 3 3 0 Ribonuclease B OB domain YflT PF11181.6 NM_008774.3_3 - 0.073 13.5 0.4 3 8.3 0.2 2.7 2 0 0 2 2 2 0 Heat induced stress protein YflT GDNF PF02351.14 NM_001302094.1_2 - 4.1e-37 126.9 29.8 1e-23 84.0 5.0 2.6 2 0 0 2 2 2 2 GDNF/GAS1 domain SelP_N PF04592.12 NM_001302094.1_2 - 9.8 5.4 11.6 20 4.4 11.6 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region FhuF_C PF11575.6 NM_001190310.1_1 - 9.4 6.1 11.6 0.83 9.5 1.5 2.5 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain Lectin_C PF00059.19 NM_001190310.1_2 - 5.7e-21 75.1 4.1 8.1e-21 74.7 4.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain CHORD PF04968.10 NM_001190310.1_2 - 0.47 11.1 4.7 0.36 11.4 2.6 1.9 2 0 0 2 2 2 0 CHORD Comm PF15957.3 NM_001190310.1_2 - 0.53 10.5 3.5 0.88 9.8 3.5 1.6 1 1 0 1 1 1 0 Commissureless Trypsin PF00089.24 NM_001045521.1_3 - 2.1e-58 197.6 0.0 2.6e-58 197.3 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_001045521.1_3 - 2.1e-06 28.0 0.2 3.6e-06 27.2 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF938 PF06080.10 NM_026686.2_1 - 2.5e-91 304.9 0.0 2.9e-91 304.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_25 PF13649.4 NM_026686.2_1 - 4.2e-06 27.2 0.0 8.2e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 NM_026686.2_1 - 0.0079 15.6 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.15 NM_026686.2_1 - 0.0095 15.3 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.10 NM_026686.2_1 - 0.055 14.1 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.17 NM_026686.2_1 - 0.064 12.9 0.0 0.091 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CDV3 PF15359.4 NM_001134427.1_2 - 3.3e-40 137.4 8.2 4.5e-40 136.9 8.2 1.2 1 0 0 1 1 1 1 Carnitine deficiency-associated protein 3 YTH PF04146.13 NM_145393.4_1 - 6.8e-40 135.4 0.0 1.1e-39 134.7 0.0 1.3 1 0 0 1 1 1 1 YT521-B-like domain TFIIA PF03153.11 NM_145393.4_1 - 2.6 7.8 8.5 5.1 6.9 8.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Bax1-I PF01027.18 NM_001199122.1_2 - 8.6e-39 133.4 16.6 8.6e-39 133.4 16.6 1.7 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 SNF PF00209.16 NM_001142809.1_3 - 2e-241 802.1 38.4 2.4e-241 801.8 38.4 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Ly49 PF08391.8 NM_010651.3_2 - 4.2e-54 181.8 3.6 7.6e-54 181.0 3.6 1.4 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Lectin_C PF00059.19 NM_010651.3_2 - 6.8e-14 52.4 3.0 6.8e-14 52.4 3.0 1.7 2 0 0 2 2 2 1 Lectin C-type domain MFS_Mycoplasma PF07672.11 NM_010651.3_2 - 0.027 13.6 0.1 0.042 13.0 0.1 1.2 1 0 0 1 1 1 0 Mycoplasma MFS transporter Tetraspannin PF00335.18 NM_010651.3_2 - 0.062 13.0 2.5 0.11 12.1 2.6 1.5 1 1 0 1 1 1 0 Tetraspanin family HS1_rep PF02218.13 NM_007803.5_3 - 4.4e-127 414.1 74.6 6.2e-21 74.4 2.7 7.5 7 0 0 7 7 7 7 Repeat in HS1/Cortactin SH3_9 PF14604.4 NM_007803.5_3 - 6.8e-17 60.9 0.2 1.4e-16 59.9 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_007803.5_3 - 4.8e-16 58.0 0.2 1e-15 56.9 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_007803.5_3 - 2.4e-09 36.6 0.0 6.3e-09 35.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.4 NM_007803.5_3 - 1.3e-06 28.7 6.6 7.8 6.8 0.0 6.7 1 1 5 7 7 7 2 TMEM210 family FadA PF09403.8 NM_007803.5_3 - 0.27 11.6 8.7 0.6 10.5 8.7 1.5 1 0 0 1 1 1 0 Adhesion protein FadA Mnd1 PF03962.13 NM_007803.5_3 - 0.59 9.8 6.1 1.3 8.7 6.1 1.5 1 0 0 1 1 1 0 Mnd1 family PV-1 PF06637.9 NM_007803.5_3 - 4 6.0 8.0 6.1 5.4 8.0 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) NAPRTase PF04095.14 NM_021524.2_2 - 9.6e-73 244.6 0.0 1.6e-72 243.9 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family Lipase PF00151.17 NM_008280.2_3 - 3.2e-134 447.4 0.0 4.7e-134 446.8 0.0 1.2 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 NM_008280.2_3 - 1.2e-23 83.7 0.2 2.1e-23 83.0 0.2 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 NM_008280.2_3 - 0.067 13.7 0.1 0.1 13.1 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family VirJ PF06057.9 NM_008280.2_3 - 0.088 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) DUF3528 PF12045.6 NM_010450.3_2 - 1.8e-63 213.3 0.2 2.5e-63 212.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3528) Homeobox PF00046.27 NM_010450.3_2 - 1.5e-19 69.4 7.4 2.4e-19 68.8 7.4 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_010450.3_2 - 0.15 11.9 0.8 0.29 11.0 0.8 1.5 1 0 0 1 1 1 0 Homeobox KN domain 7tm_3 PF00003.20 NM_001102580.1_1 - 1.9e-56 191.3 30.9 1.9e-56 191.3 30.9 2.0 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001102580.1_1 - 2.5e-30 105.6 0.0 5e-30 104.7 0.0 1.3 1 1 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001102580.1_1 - 1.7e-19 69.4 10.2 3.4e-19 68.4 10.2 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR AzlD PF05437.10 NM_001102580.1_1 - 2.5 8.2 11.1 1.9 8.6 5.7 3.0 2 0 0 2 2 2 0 Branched-chain amino acid transport protein (AzlD) V-set PF07686.15 NM_007675.4_1 - 1.4e-19 70.1 0.0 5.6e-09 36.0 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_007675.4_1 - 8.9e-08 32.5 0.0 0.013 16.0 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_007675.4_1 - 0.01 15.7 0.0 3.1 7.8 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin I-set domain ig PF00047.23 NM_007675.4_1 - 0.11 12.6 0.1 3.5 7.7 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain NACHT PF05729.10 NM_177690.3_3 - 2.9e-28 98.8 0.0 8.2e-28 97.3 0.0 1.9 1 0 0 1 1 1 1 NACHT domain PYRIN PF02758.14 NM_177690.3_3 - 4.6e-15 55.4 0.3 2.2e-14 53.3 0.3 2.3 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain LRR_6 PF13516.4 NM_177690.3_3 - 1.8e-11 43.0 24.1 0.00045 19.9 0.8 6.4 6 0 0 6 6 5 3 Leucine Rich repeat AAA_22 PF13401.4 NM_177690.3_3 - 8e-05 22.8 0.0 0.00031 20.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 NM_177690.3_3 - 0.00016 21.9 0.0 0.0015 18.8 0.0 2.5 3 0 0 3 3 2 1 AAA ATPase domain AAA PF00004.27 NM_177690.3_3 - 0.00024 21.4 0.0 0.0014 19.0 0.0 2.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.19 NM_177690.3_3 - 0.0009 18.5 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.20 NM_177690.3_3 - 0.0011 19.2 0.8 0.017 15.3 0.0 3.4 4 0 0 4 4 3 1 RNA helicase AAA_33 PF13671.4 NM_177690.3_3 - 0.0027 17.8 0.0 0.0063 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.4 NM_177690.3_3 - 0.0034 17.6 0.0 0.012 15.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.4 NM_177690.3_3 - 0.0044 17.4 0.0 0.015 15.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.4 NM_177690.3_3 - 0.016 14.7 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 NM_177690.3_3 - 0.024 14.2 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.16 NM_177690.3_3 - 0.025 14.2 0.0 0.069 12.7 0.0 1.8 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TsaE PF02367.15 NM_177690.3_3 - 0.027 14.4 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.16 NM_177690.3_3 - 0.031 14.0 0.0 0.084 12.6 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_14 PF13173.4 NM_177690.3_3 - 0.035 14.0 0.0 0.35 10.8 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.4 NM_177690.3_3 - 0.048 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.8 NM_177690.3_3 - 0.058 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 cobW PF02492.17 NM_177690.3_3 - 0.084 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.4 NM_177690.3_3 - 0.089 12.9 0.0 0.29 11.2 0.0 1.9 2 0 0 2 2 1 0 AAA domain RuvB_N PF05496.10 NM_177690.3_3 - 0.099 11.8 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 NM_177690.3_3 - 0.13 12.2 0.0 0.39 10.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) LRR_4 PF12799.5 NM_177690.3_3 - 0.29 11.5 31.5 0.58 10.5 1.1 6.9 3 2 5 8 8 8 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_177690.3_3 - 2.6 7.8 20.6 0.45 10.2 0.3 5.2 5 0 0 5 5 4 0 Leucine rich repeat Beach PF02138.16 NM_001077688.1_1 - 6.7e-125 415.9 0.7 9.9e-125 415.3 0.7 1.3 1 0 0 1 1 1 1 Beige/BEACH domain DUF4704 PF15787.3 NM_001077688.1_1 - 4.5e-106 354.0 7.0 4.5e-106 354.0 7.0 2.8 1 1 2 3 3 3 1 Domain of unknown function (DUF4704) DUF1088 PF06469.9 NM_001077688.1_1 - 1.6e-84 281.6 3.9 3.2e-84 280.6 3.9 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) PH_BEACH PF14844.4 NM_001077688.1_1 - 1.8e-29 101.6 0.2 8.7e-28 96.2 0.0 2.9 3 0 0 3 3 3 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.4 NM_001077688.1_1 - 7.3e-12 45.5 0.2 9e-11 42.0 0.0 2.6 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.30 NM_001077688.1_1 - 0.00027 21.5 3.3 0.78 10.6 0.2 4.5 3 0 0 3 3 3 1 WD domain, G-beta repeat SUKH_6 PF14568.4 NM_001077688.1_1 - 0.087 13.1 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Interferon PF00143.17 NM_001243166.1_2 - 2.1e-26 92.9 0.0 3.2e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Interferon alpha/beta domain NAGLU_N PF12971.5 NM_001243166.1_2 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain S1 PF00575.21 NM_026329.2_1 - 2.5e-20 72.5 0.1 4.2e-20 71.7 0.1 1.4 1 0 0 1 1 1 1 S1 RNA binding domain SHS2_Rpb7-N PF03876.15 NM_026329.2_1 - 9.1e-15 54.7 0.0 1.8e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.10 NM_026329.2_1 - 0.00014 22.0 0.0 0.00023 21.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Kelch_1 PF01344.23 NM_001081403.1_1 - 1.9e-45 152.1 16.1 1.7e-12 46.6 0.1 7.2 6 1 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 NM_001081403.1_1 - 3.2e-33 112.8 11.1 5.7e-08 32.6 0.1 6.2 1 1 5 6 6 6 5 Kelch motif Kelch_2 PF07646.13 NM_001081403.1_1 - 2.8e-23 80.8 9.1 0.00042 20.1 0.0 6.9 7 0 0 7 7 7 6 Kelch motif BTB PF00651.29 NM_001081403.1_1 - 4.6e-23 81.4 0.0 1.6e-12 47.5 0.0 2.6 2 0 0 2 2 2 2 BTB/POZ domain Kelch_3 PF13415.4 NM_001081403.1_1 - 1.2e-22 79.5 2.8 2.3e-06 27.6 0.1 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.4 NM_001081403.1_1 - 9e-17 60.6 2.0 1.9e-07 30.8 0.0 5.5 5 1 1 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_001081403.1_1 - 2.5e-11 43.1 6.1 0.0015 18.3 0.1 5.4 5 0 0 5 5 5 4 Kelch motif BACK PF07707.13 NM_001081403.1_1 - 1.6e-09 37.6 0.6 3.9e-09 36.4 0.4 1.7 1 1 0 1 1 1 1 BTB And C-terminal Kelch SUIM_assoc PF16619.3 NM_001081403.1_1 - 0.023 14.7 6.8 0.048 13.6 6.8 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF4589 PF15252.4 NM_001081224.2_1 - 1.6e-75 254.2 5.1 2.6e-75 253.5 5.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4589) Reo_sigmaC PF04582.10 NM_001081224.2_1 - 1.1 8.4 3.5 1.8 7.7 3.5 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein LRR_8 PF13855.4 NM_001195544.1_3 - 8.3e-19 67.0 0.9 7.7e-17 60.7 0.2 2.1 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 NM_001195544.1_3 - 1.4e-08 34.7 0.0 0.00038 20.6 0.0 2.3 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001195544.1_3 - 1.3e-05 24.9 0.0 0.36 11.3 0.0 3.6 3 0 0 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.4 NM_001195544.1_3 - 0.0075 16.1 0.4 4.7 7.4 0.0 2.5 2 0 0 2 2 2 2 Leucine Rich repeat 7tm_1 PF00001.19 NM_201367.3_2 - 1.4e-28 99.7 29.3 2e-28 99.2 29.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3740 PF12548.6 NM_172294.1_2 - 5.4e-59 198.7 10.3 3.8e-53 179.8 0.1 2.4 2 0 0 2 2 2 2 Sulfatase protein Sulfatase PF00884.21 NM_172294.1_2 - 3.5e-56 190.7 0.5 5.7e-56 190.0 0.5 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.20 NM_172294.1_2 - 0.0053 16.2 4.3 0.033 13.6 1.8 2.5 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase TPR_12 PF13424.4 NM_001025361.2_3 - 1.2e-64 214.4 21.7 1.6e-19 69.9 1.7 5.4 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001025361.2_3 - 2.2e-61 202.0 15.9 1.2e-15 56.7 0.0 7.0 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001025361.2_3 - 5.1e-31 104.2 16.1 6.9e-06 25.6 0.0 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001025361.2_3 - 9.9e-27 91.5 29.9 2e-07 30.4 0.5 6.8 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001025361.2_3 - 2.1e-18 64.8 26.4 0.001 18.9 0.4 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001025361.2_3 - 3.7e-12 45.3 26.3 0.0022 18.0 0.1 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001025361.2_3 - 5.9e-12 45.8 8.0 0.00011 22.4 0.1 4.5 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001025361.2_3 - 3.4e-10 40.3 17.1 0.0015 19.0 2.2 6.4 3 1 3 6 6 5 4 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001025361.2_3 - 5.2e-09 35.8 7.3 0.2 12.0 0.0 6.3 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001025361.2_3 - 6.2e-09 35.8 9.0 1.7 9.5 0.4 7.0 3 1 3 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001025361.2_3 - 2.5e-06 27.5 11.0 0.031 14.3 0.5 4.2 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.12 NM_001025361.2_3 - 7.1e-06 26.0 2.2 14 6.5 0.1 6.9 9 0 0 9 9 6 0 Tetratricopeptide repeat PPR PF01535.18 NM_001025361.2_3 - 0.00023 21.0 0.3 0.19 11.9 0.0 4.0 5 0 0 5 5 3 1 PPR repeat JIP_LZII PF16471.3 NM_001025361.2_3 - 0.011 15.7 7.7 0.011 15.7 7.7 2.6 1 1 0 2 2 2 0 JNK-interacting protein leucine zipper II PPR_2 PF13041.4 NM_001025361.2_3 - 0.11 12.6 1.1 3.3 7.8 0.0 3.3 3 0 0 3 3 3 0 PPR repeat family GHL5 PF14872.4 NM_001025361.2_3 - 0.15 10.0 5.5 0.22 9.4 5.5 1.2 1 0 0 1 1 1 0 Hypothetical glycoside hydrolase 5 DUF4919 PF16266.3 NM_001025361.2_3 - 0.32 10.8 3.5 0.43 10.4 0.0 2.9 3 2 1 4 4 3 0 Domain of unknown function (DUF4919) COG2 PF06148.9 NM_001025361.2_3 - 0.79 9.7 8.8 0.4 10.6 5.9 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TMF_TATA_bd PF12325.6 NM_001025361.2_3 - 0.81 9.8 20.3 0.033 14.3 11.0 2.8 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding MIT PF04212.16 NM_001025361.2_3 - 1.1 9.2 11.0 37 4.4 1.9 5.3 4 1 1 5 5 4 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.7 NM_001025361.2_3 - 1.1 8.6 3.7 13 5.2 0.1 3.6 4 0 0 4 4 4 0 SHNi-TPR DUF627 PF04781.10 NM_001025361.2_3 - 1.2 9.0 5.8 4.2 7.3 0.0 3.4 3 1 1 4 4 3 0 Protein of unknown function (DUF627) Exonuc_VII_L PF02601.13 NM_001025361.2_3 - 6.7 6.0 10.5 20 4.5 10.5 1.8 1 0 0 1 1 1 0 Exonuclease VII, large subunit Period_C PF12114.6 NM_001289877.1_2 - 2.8e-31 108.5 3.7 2.8e-31 108.5 3.7 3.6 3 1 1 4 4 4 1 Period protein 2/3C-terminal region PAS_3 PF08447.10 NM_001289877.1_2 - 3e-14 52.9 0.0 6.2e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.4 NM_001289877.1_2 - 1.5e-08 34.6 0.0 3.4e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS PF00989.23 NM_001289877.1_2 - 1.6e-06 27.9 0.0 6.3e-06 26.0 0.0 2.0 2 0 0 2 2 2 1 PAS fold Ribul_P_3_epim PF00834.17 NM_001310644.1_2 - 0.015 14.5 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Ribul_P_3_epim PF00834.17 NM_001310644.1_3 - 1.3e-51 174.7 0.0 1.7e-51 174.3 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.17 NM_001310644.1_3 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain CASP_C PF08172.10 NM_001291240.1_3 - 2.6e-58 197.2 2.1 2.6e-58 197.2 2.1 5.4 2 2 2 4 4 4 1 CASP C terminal NDUF_B8 PF05821.9 NM_001291240.1_3 - 0.091 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) ZapB PF06005.10 NM_001291240.1_3 - 0.32 11.4 0.1 0.32 11.4 0.1 7.6 5 2 2 7 7 7 0 Cell division protein ZapB HOOK PF05622.10 NM_001291240.1_3 - 5.5 4.9 73.8 0.68 7.9 59.9 3.4 2 1 1 3 3 3 0 HOOK protein DUF4407 PF14362.4 NM_001291240.1_3 - 7.1 5.8 53.5 5.9 6.0 0.0 4.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4407) Serpin PF00079.18 NM_011456.2_2 - 1e-124 416.5 0.5 1.2e-124 416.3 0.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-C3HC PF07967.11 NM_172735.2_3 - 3.7e-35 120.7 6.2 5.1e-35 120.2 0.0 3.0 3 0 0 3 3 3 1 C3HC zinc finger-like Rsm1 PF08600.8 NM_172735.2_3 - 3.7e-16 58.9 4.6 1.9e-10 40.6 0.0 3.0 3 0 0 3 3 3 2 Rsm1-like Yippee-Mis18 PF03226.12 NM_172735.2_3 - 0.053 13.6 3.5 0.71 10.0 0.0 2.4 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Ion_trans PF00520.29 NM_133199.2_2 - 3.9e-251 828.5 102.1 2.7e-80 269.0 14.2 4.1 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.11 NM_133199.2_2 - 7.2e-57 192.6 2.2 1.6e-56 191.5 0.0 2.3 2 0 0 2 2 2 1 Sodium ion transport-associated PKD_channel PF08016.10 NM_133199.2_2 - 4.3e-06 25.6 83.1 0.00013 20.7 0.2 9.4 7 3 3 10 10 10 7 Polycystin cation channel GPHH PF16905.3 NM_133199.2_2 - 2.5e-05 23.8 0.0 6.7e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.25 NM_133199.2_2 - 0.007 15.9 1.0 0.018 14.7 1.0 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif Lustrin_cystein PF14625.4 NM_133199.2_2 - 1.2 9.5 6.0 0.22 11.8 0.3 2.5 2 0 0 2 2 2 0 Lustrin, cysteine-rich repeated domain Takusan PF04822.11 NM_001033214.2_1 - 0.16 11.8 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Takusan Filament PF00038.19 NM_001033214.2_2 - 0.027 13.9 37.7 0.43 10.0 23.6 2.3 1 1 1 2 2 2 0 Intermediate filament protein HOOK PF05622.10 NM_001033214.2_2 - 0.08 11.0 38.7 0.11 10.5 38.7 1.1 1 0 0 1 1 1 0 HOOK protein Baculo_PEP_C PF04513.10 NM_001033214.2_2 - 1.4 8.8 6.4 0.65 9.9 0.3 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.9 NM_001033214.2_2 - 2.9 8.2 12.7 5.3 7.4 0.4 4.0 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) FAM184 PF15665.3 NM_001033214.2_2 - 3.1 7.4 46.0 6 6.4 23.0 2.2 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B zf-C2HC PF01530.16 NM_001244693.1_1 - 1.7e-80 264.7 80.3 2.2e-15 56.4 7.4 6.6 6 0 0 6 6 6 6 Zinc finger, C2HC type MYT1 PF08474.9 NM_001244693.1_1 - 4.5e-74 249.2 0.8 8.8e-74 248.3 0.8 1.5 1 0 0 1 1 1 1 Myelin transcription factor 1 DUF812 PF05667.9 NM_001244693.1_1 - 0.018 13.9 4.7 0.029 13.1 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) ADIP PF11559.6 NM_001244693.1_1 - 0.047 13.6 3.4 0.1 12.6 3.4 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.9 NM_001244693.1_1 - 0.06 13.4 5.9 0.17 12.0 5.9 1.7 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF972 PF06156.11 NM_001244693.1_1 - 0.094 13.2 3.4 0.26 11.8 3.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF342 PF03961.11 NM_001244693.1_1 - 0.12 10.8 3.3 0.2 10.1 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) HAUS-augmin3 PF14932.4 NM_001244693.1_1 - 0.17 11.3 5.2 0.31 10.4 5.2 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 CENP-H PF05837.10 NM_001244693.1_1 - 0.18 12.1 5.1 0.12 12.7 2.7 2.0 2 0 0 2 2 1 0 Centromere protein H (CENP-H) DUF1664 PF07889.10 NM_001244693.1_1 - 0.19 11.6 0.9 0.44 10.4 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SlyX PF04102.10 NM_001244693.1_1 - 0.21 12.1 3.6 0.54 10.8 3.6 1.7 1 0 0 1 1 1 0 SlyX APG6 PF04111.10 NM_001244693.1_1 - 0.39 9.9 5.7 0.8 8.9 5.7 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 TMF_DNA_bd PF12329.6 NM_001244693.1_1 - 0.99 9.3 13.3 2.9 7.8 13.3 1.8 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.6 NM_001244693.1_1 - 1.9 7.6 5.2 3 6.9 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DivIC PF04977.13 NM_001244693.1_1 - 4.4 7.0 5.0 4.9 6.9 3.3 1.9 1 1 1 2 2 2 0 Septum formation initiator IBR PF01485.19 NM_001244693.1_1 - 7.4 6.8 16.7 31 4.8 0.1 5.5 4 1 1 5 5 5 0 IBR domain, a half RING-finger domain UQ_con PF00179.24 NM_001039158.2_3 - 1.4e-17 63.6 0.0 2.2e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SelR PF01641.16 NM_177092.4_1 - 5.2e-53 178.1 0.1 7.9e-53 177.5 0.1 1.3 1 0 0 1 1 1 1 SelR domain zf-ribbon_3 PF13248.4 NM_177092.4_1 - 0.2 11.0 1.9 6.3 6.2 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain RRM_1 PF00076.20 NM_001110232.1_1 - 3.2e-49 164.5 0.0 4.6e-17 61.5 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 NM_001110232.1_1 - 1.2e-07 31.5 0.0 0.6 10.0 0.0 3.5 3 0 0 3 3 3 3 RNA binding domain RRM_7 PF16367.3 NM_001110232.1_1 - 0.0035 17.3 0.0 1.5 8.9 0.0 3.1 3 0 0 3 3 3 1 RNA recognition motif PHM7_cyt PF14703.4 NM_001110232.1_1 - 0.093 12.8 0.9 4.6 7.3 0.0 3.1 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter PID PF00640.21 NM_001201415.1_2 - 7.7e-50 168.4 0.0 3.1e-37 127.6 0.0 2.3 2 0 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 NM_001201415.1_2 - 1.1e-06 28.7 0.0 0.00095 19.2 0.0 2.4 2 0 0 2 2 2 2 Phosphotyrosine-binding domain WW PF00397.24 NM_001201415.1_2 - 6.5e-06 25.9 2.9 1.3e-05 24.9 2.9 1.5 1 0 0 1 1 1 1 WW domain ST7 PF04184.10 NM_001289624.1_3 - 0 1058.0 3.2 0 1057.3 3.2 1.3 1 1 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 NM_001289624.1_3 - 0.00091 19.6 0.0 0.0041 17.5 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001289624.1_3 - 0.01 15.7 0.2 6 7.1 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Clathrin PF00637.18 NM_001289624.1_3 - 0.082 12.6 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 NM_001289624.1_3 - 0.22 11.9 4.5 0.5 10.8 0.4 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001289624.1_3 - 0.98 10.3 5.5 17 6.4 0.1 4.3 3 2 1 4 4 4 0 Tetratricopeptide repeat PRY PF13765.4 NM_001025599.3_2 - 2.1e-13 49.6 0.1 6.4e-13 48.0 0.0 2.0 2 0 0 2 2 1 1 SPRY-associated domain SPRY PF00622.26 NM_001025599.3_2 - 3.4e-12 46.4 0.0 1.3e-11 44.6 0.0 2.0 2 0 0 2 2 2 1 SPRY domain zf-C3HC4_4 PF15227.4 NM_001025599.3_2 - 1.1e-10 41.3 7.8 1.1e-10 41.3 7.8 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 NM_001025599.3_2 - 1.2e-09 37.7 5.8 1.2e-09 37.7 5.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001025599.3_2 - 3e-09 36.5 5.6 8e-09 35.1 5.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 NM_001025599.3_2 - 7.2e-09 35.5 4.0 7.2e-09 35.5 4.0 3.2 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_2 PF13923.4 NM_001025599.3_2 - 1.5e-08 34.2 6.5 3.8e-08 32.9 6.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001025599.3_2 - 2e-08 34.0 6.6 2.5e-08 33.7 3.3 2.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_001025599.3_2 - 4.2e-07 30.0 7.5 4.2e-07 30.0 7.5 2.2 2 0 0 2 2 1 1 Ring finger domain zf-RING_6 PF14835.4 NM_001025599.3_2 - 1.1e-06 28.3 3.4 2.6e-06 27.1 3.4 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.4 NM_001025599.3_2 - 1.8e-05 24.5 5.5 1.8e-05 24.5 5.5 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.4 NM_001025599.3_2 - 9.8e-05 22.0 7.3 9.8e-05 22.0 7.3 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Baculo_IE-1 PF05290.9 NM_001025599.3_2 - 0.0024 17.7 1.8 0.0048 16.7 1.8 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Nop14 PF04147.10 NM_001025599.3_2 - 0.0043 15.2 7.0 0.0062 14.7 7.0 1.1 1 0 0 1 1 1 1 Nop14-like family zf-RING_10 PF16685.3 NM_001025599.3_2 - 0.0073 16.3 3.8 0.0073 16.3 3.8 2.1 2 0 0 2 2 2 1 zinc RING finger of MSL2 CDC45 PF02724.12 NM_001025599.3_2 - 0.052 11.7 2.0 0.074 11.2 2.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Rtf2 PF04641.10 NM_001025599.3_2 - 0.086 12.1 0.1 0.086 12.1 0.1 1.8 2 0 0 2 2 2 0 Rtf2 RING-finger zf-RING_4 PF14570.4 NM_001025599.3_2 - 1.3 8.7 10.5 0.1 12.2 5.3 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Reprolysin PF01421.17 NM_007400.2_2 - 2.8e-72 242.7 0.0 5.5e-72 241.7 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_007400.2_2 - 3.1e-33 114.5 3.2 3.1e-33 114.5 3.2 3.7 3 0 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 NM_007400.2_2 - 5e-27 94.7 0.0 1.1e-26 93.6 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_007400.2_2 - 5.7e-22 78.7 0.0 1.1e-21 77.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 NM_007400.2_2 - 1.4e-18 67.4 30.6 1.4e-18 67.4 30.6 4.2 4 0 0 4 4 4 1 Disintegrin Reprolysin_3 PF13582.4 NM_007400.2_2 - 2.1e-13 50.7 0.0 3.6e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_007400.2_2 - 2.7e-12 46.9 0.0 4.3e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_007400.2_2 - 4.6e-12 45.9 0.0 8.8e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like T-box PF00907.20 NM_172798.1_2 - 5e-66 222.3 0.2 1e-65 221.3 0.1 1.5 2 0 0 2 2 2 1 T-box DOR PF14839.4 NM_021897.3_3 - 2.6e-81 273.1 11.2 5.8e-81 272.0 11.2 1.6 1 1 0 1 1 1 1 DOR family SYCE1 PF15233.4 NM_001048145.1_1 - 2.4e-45 154.2 35.1 2e-43 147.9 20.0 3.9 3 1 0 3 3 3 1 Synaptonemal complex central element protein 1 Unstab_antitox PF09720.8 NM_001048145.1_1 - 0.049 13.6 0.1 0.049 13.6 0.1 3.8 3 0 0 3 3 3 0 Putative addiction module component TEX12 PF15219.4 NM_001048145.1_1 - 0.05 13.8 1.8 0.2 11.9 0.4 2.2 2 0 0 2 2 2 0 Testis-expressed 12 Lebercilin PF15619.4 NM_001048145.1_1 - 0.32 10.5 36.7 0.7 9.4 6.3 3.0 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease YojJ PF10372.7 NM_001048145.1_1 - 0.36 10.8 0.0 0.36 10.8 0.0 3.3 3 3 1 4 4 4 0 Bacterial membrane-spanning protein N-terminus DUF342 PF03961.11 NM_001048145.1_1 - 0.4 9.1 15.9 0.023 13.2 4.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF342) GAS PF13851.4 NM_001048145.1_1 - 4.4 6.5 29.9 0.053 12.8 17.7 3.0 3 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding DUF4407 PF14362.4 NM_001048145.1_1 - 5.3 6.2 17.3 1.1 8.4 10.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) PRKG1_interact PF15898.3 NM_001048145.1_1 - 6.5 7.6 26.1 4 8.3 9.0 3.2 2 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain CutC PF03932.12 NM_025530.3_3 - 4.2e-68 228.7 0.0 7.5e-68 227.9 0.0 1.4 1 0 0 1 1 1 1 CutC family Calcyon PF06387.9 NM_001290681.1_3 - 4.1e-70 235.3 0.2 8.9e-70 234.2 0.2 1.5 1 1 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) AlbA_2 PF04326.12 NM_011409.1_3 - 2.6e-11 43.8 0.2 3.2e-08 33.8 0.0 2.8 3 0 0 3 3 3 2 Putative DNA-binding domain Ribosomal_S27e PF01667.15 NM_027015.4_1 - 3e-30 103.6 5.1 3.8e-30 103.2 5.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 ODC_AZ PF02100.15 NM_001301034.1_1 - 9e-21 73.9 0.0 1.4e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Mei5 PF10376.7 NM_026377.2_3 - 1.5e-69 233.9 15.4 3.5e-69 232.7 15.4 1.7 1 0 0 1 1 1 1 Double-strand recombination repair protein Mei5_like PF17021.3 NM_026377.2_3 - 0.047 13.6 3.6 0.094 12.6 3.6 1.5 1 1 0 1 1 1 0 Putative double-strand recombination repair-like G10 PF01125.15 NM_026377.2_3 - 0.23 11.1 4.3 0.45 10.1 3.9 1.5 1 1 0 1 1 1 0 G10 protein FAM76 PF16046.3 NM_026377.2_3 - 0.36 10.0 13.5 0.73 9.0 13.5 1.4 2 0 0 2 2 2 0 FAM76 protein TNF PF00229.16 NM_011614.3_3 - 2.3e-14 53.3 0.0 3.2e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 NM_011614.3_3 - 0.012 15.7 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 C1q domain SRPRB PF09439.8 NM_009275.4_1 - 4.6e-72 241.1 0.4 6.4e-72 240.6 0.4 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.19 NM_009275.4_1 - 1.3e-14 53.9 0.0 2e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_009275.4_1 - 4.1e-07 29.9 0.0 6.5e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 NM_009275.4_1 - 2.1e-05 24.0 0.0 0.00033 20.1 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.11 NM_009275.4_1 - 6e-05 23.1 0.0 9.3e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.16 NM_009275.4_1 - 0.00051 19.5 0.0 0.00091 18.6 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.20 NM_009275.4_1 - 0.0029 17.1 0.0 0.007 15.8 0.0 1.6 1 1 0 1 1 1 1 Ras family PDDEXK_1 PF12705.5 NM_028984.5_1 - 1.1e-06 28.6 0.0 3.8e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily NTP_transf_2 PF01909.21 NM_001164497.1_3 - 2.6e-15 56.4 0.2 4.4e-15 55.6 0.2 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.17 NM_001164497.1_3 - 2.7e-14 53.0 0.0 5.6e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase DDHD PF02862.15 NM_001024927.2_2 - 1.5e-43 149.6 1.0 1.3e-42 146.4 1.0 2.1 1 1 0 1 1 1 1 DDHD domain LNS2 PF08235.11 NM_001024927.2_2 - 0.013 14.9 0.0 0.03 13.7 0.0 1.5 1 1 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) Acid_phosphat_B PF03767.12 NM_001024927.2_2 - 0.024 14.1 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) RhoGEF PF00621.18 NM_153804.4_2 - 6.8e-45 153.4 0.6 1.2e-44 152.6 0.6 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 NM_153804.4_2 - 1.4e-07 31.8 0.1 3.3e-07 30.6 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 NM_153804.4_2 - 0.018 15.1 0.8 0.22 11.7 0.8 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.3 NM_153804.4_2 - 0.068 12.9 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain UCH PF00443.27 NM_001252486.1_1 - 4.4e-64 216.3 0.0 3.5e-63 213.3 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001252486.1_1 - 6.6e-33 114.5 1.3 2.2e-21 76.6 0.0 2.2 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.10 NM_001252486.1_1 - 1.7e-24 86.1 0.0 1e-13 51.6 0.0 2.7 2 0 0 2 2 2 2 DUSP domain zf-UBP PF02148.17 NM_001252486.1_1 - 3.8e-16 59.0 7.9 3.8e-16 59.0 7.9 3.5 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein RILP PF11461.6 NM_001252486.1_1 - 0.14 12.3 3.9 0.37 10.9 3.9 1.7 1 0 0 1 1 1 0 Rab interacting lysosomal protein 7tm_4 PF13853.4 NM_207571.2_3 - 1.5e-47 162.5 26.0 2.2e-47 162.0 26.0 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207571.2_3 - 9.4e-21 74.1 28.5 3.4e-20 72.3 28.5 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_207571.2_3 - 0.00099 18.4 25.2 0.0055 16.0 25.2 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Hormone_1 PF00103.18 NM_013766.2_2 - 5.4e-29 101.3 3.6 6.8e-29 101.0 3.6 1.1 1 0 0 1 1 1 1 Somatotropin hormone family HEAT_EZ PF13513.4 NM_001282443.1_1 - 0.0016 18.7 35.5 0.022 15.1 1.6 7.9 7 1 1 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.4 NM_001282443.1_1 - 1.4 9.2 14.1 0.38 11.0 1.3 4.5 2 1 3 5 5 5 0 HEAT repeats HEAT PF02985.20 NM_001282443.1_1 - 2.3 8.6 15.1 3.2 8.1 0.1 6.0 7 0 0 7 7 7 0 HEAT repeat RRM_1 PF00076.20 NM_001166371.1_3 - 2.8e-07 30.1 0.0 0.035 13.8 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001166371.1_3 - 6.4e-05 22.4 0.1 0.79 9.2 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_jaz PF12171.6 NM_001166371.1_3 - 0.00012 22.1 0.8 0.00012 22.1 0.8 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.10 NM_001166371.1_3 - 0.0021 18.2 1.0 1.5 8.9 0.1 2.7 2 0 0 2 2 2 2 A-kinase anchoring protein 95 (AKAP95) zf-met PF12874.5 NM_001166371.1_3 - 0.017 15.4 14.6 0.34 11.2 1.6 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type 7tm_4 PF13853.4 NM_146518.1_1 - 4.9e-50 170.7 11.8 5.6e-50 170.5 11.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146518.1_1 - 2.5e-23 82.6 19.8 5.4e-23 81.4 19.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_146518.1_1 - 0.02 14.3 1.0 0.036 13.5 0.1 1.9 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus Transglut_N PF00868.18 NM_177911.4_1 - 1.6e-24 86.3 0.2 1.1e-23 83.7 0.0 2.3 2 0 0 2 2 2 1 Transglutaminase family Transglut_C PF00927.20 NM_177911.4_1 - 7.3e-20 70.9 2.1 1.1e-17 64.0 0.2 2.6 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.17 NM_177911.4_1 - 1.5e-15 57.4 0.2 2.9e-15 56.6 0.2 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily ASH PF15780.3 NM_177911.4_1 - 0.012 15.7 0.7 0.032 14.3 0.1 2.1 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin BAR_3 PF16746.3 NM_001313755.1_2 - 2.5e-60 204.0 19.1 3.7e-31 108.5 9.5 2.2 1 1 1 2 2 2 2 BAR domain of APPL family RhoGAP PF00620.25 NM_001313755.1_2 - 3.8e-41 140.3 0.0 8.4e-41 139.2 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 NM_001313755.1_2 - 3.5e-08 33.8 0.0 1e-07 32.3 0.0 1.8 1 0 0 1 1 1 1 PH domain Sulfotransfer_2 PF03567.12 NM_001290467.1_1 - 2.1e-75 253.8 0.7 3.6e-75 253.0 0.1 1.7 2 0 0 2 2 2 1 Sulfotransferase family Trypan_PARP PF05887.9 NM_001290467.1_3 - 0.82 9.6 17.5 1.4 8.9 17.5 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) FXMRP1_C_core PF12235.6 NM_008031.3_1 - 7.5e-46 156.0 10.8 7.5e-46 156.0 10.8 3.2 3 1 1 4 4 4 1 Fragile X-related 1 protein core C terminal FXMR_C2 PF16098.3 NM_008031.3_1 - 1.4e-18 67.0 9.3 2.9e-15 56.4 5.5 3.6 2 1 0 2 2 2 1 Fragile X-related mental retardation protein C-terminal region 2 KH_1 PF00013.27 NM_008031.3_1 - 6.9e-15 54.5 1.8 2.1e-07 30.5 1.6 2.6 2 0 0 2 2 2 2 KH domain Agenet PF05641.10 NM_008031.3_1 - 7.5e-12 45.4 1.7 6.4e-06 26.4 0.5 2.7 2 0 0 2 2 2 2 Agenet domain KH_2 PF07650.15 NM_008031.3_1 - 0.03 14.0 1.3 1.9 8.2 0.0 2.4 2 0 0 2 2 2 0 KH domain ANF_receptor PF01094.26 NM_001113181.1_3 - 4.8e-64 216.5 0.0 5.9e-64 216.3 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.4 NM_001113181.1_3 - 0.003 17.2 0.0 0.0062 16.1 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding protein TPR_19 PF14559.4 NM_001005858.3_2 - 2.3e-16 59.9 4.6 1.3e-05 25.5 0.2 4.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001005858.3_2 - 4.3e-12 45.1 8.2 0.023 14.8 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001005858.3_2 - 4.9e-10 39.4 2.9 5.6e-05 23.2 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001005858.3_2 - 2.5e-09 36.4 10.5 0.1 12.6 0.0 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001005858.3_2 - 3.9e-08 32.7 9.0 0.074 12.8 0.0 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001005858.3_2 - 1.7e-07 31.3 6.7 0.18 12.6 0.0 6.3 2 2 4 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001005858.3_2 - 8.9e-07 28.4 0.2 3.1 7.4 0.0 5.1 5 0 0 5 5 5 2 TPR repeat TPR_17 PF13431.4 NM_001005858.3_2 - 1.5e-06 28.0 7.0 0.14 12.5 0.1 5.4 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001005858.3_2 - 0.00033 20.3 4.7 0.16 12.0 0.0 4.9 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001005858.3_2 - 0.00044 19.9 1.1 0.24 11.2 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.6 NM_001005858.3_2 - 0.00062 18.7 3.8 0.00064 18.6 0.0 2.6 3 1 0 3 3 3 1 NMDA receptor-regulated protein 1 ChAPs PF09295.8 NM_001005858.3_2 - 0.0036 16.2 0.1 0.006 15.5 0.1 1.3 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_6 PF13174.4 NM_001005858.3_2 - 0.0063 16.9 3.5 3.7 8.3 0.2 4.3 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001005858.3_2 - 0.01 16.4 0.0 3.6 8.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.4 NM_001005858.3_2 - 0.034 14.3 7.8 9.1 6.6 0.1 4.2 4 1 1 5 5 4 0 Tetratricopeptide repeat L27 PF02828.14 NM_001005858.3_2 - 0.04 13.5 0.3 0.57 9.8 0.0 2.6 2 0 0 2 2 2 0 L27 domain TPR_15 PF13429.4 NM_001005858.3_2 - 0.043 12.9 3.5 0.15 11.2 0.6 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001005858.3_2 - 0.058 13.5 8.2 11 6.1 0.0 4.5 2 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 CALM_bind PF16025.3 NM_001005858.3_2 - 0.062 13.6 0.6 0.19 12.0 0.6 1.9 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding DUF4810 PF16068.3 NM_001005858.3_2 - 0.079 13.4 0.0 0.24 11.8 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4810) Sec16_C PF12931.5 NM_001005858.3_2 - 0.094 12.2 0.3 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 Sec23-binding domain of Sec16 BBIP10 PF14777.4 NM_001195338.1_2 - 1.3e-30 104.6 6.8 2.1e-30 103.9 6.8 1.3 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 SHNi-TPR PF10516.7 NM_016777.3_3 - 4.5e-14 51.5 4.3 1.7e-13 49.7 2.0 2.7 2 0 0 2 2 2 1 SHNi-TPR TPR_2 PF07719.15 NM_016777.3_3 - 2.6e-09 36.4 2.8 0.016 15.1 0.1 4.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_016777.3_3 - 1.8e-08 34.4 3.8 1.8e-08 34.4 3.8 3.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.26 NM_016777.3_3 - 6e-08 32.0 2.5 0.0011 18.5 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_016777.3_3 - 4e-05 23.4 3.6 0.29 11.3 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_016777.3_3 - 0.011 16.3 2.7 0.23 12.3 0.1 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_016777.3_3 - 0.085 12.6 2.4 7 6.6 0.1 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.4 NM_016777.3_3 - 0.089 13.4 2.2 24 5.6 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 NM_016777.3_3 - 0.16 11.6 4.4 46 3.7 2.0 4.4 2 1 2 4 4 4 0 TPR repeat TPR_6 PF13174.4 NM_016777.3_3 - 0.25 11.9 3.7 24 5.7 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat WD40 PF00400.30 NM_008142.4_1 - 6.2e-41 137.5 21.4 5.8e-08 33.2 0.0 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_008142.4_1 - 3.9e-14 52.6 0.0 0.0013 18.9 0.0 5.4 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_008142.4_1 - 0.00024 20.4 0.0 0.0016 17.7 0.0 2.0 1 1 1 2 2 2 1 WD40-like domain eIF2A PF08662.9 NM_008142.4_1 - 0.00076 19.3 0.0 0.98 9.1 0.0 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Myc-LZ PF02344.13 NM_008142.4_1 - 0.093 12.7 0.5 0.19 11.7 0.5 1.4 1 0 0 1 1 1 0 Myc leucine zipper domain CALM_bind PF16025.3 NM_008142.4_1 - 0.16 12.3 0.7 0.29 11.5 0.7 1.3 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding DUF4407 PF14362.4 NM_008142.4_1 - 0.34 10.1 1.1 0.51 9.5 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Forkhead PF00250.16 NM_148935.2_3 - 6.6e-31 106.3 0.1 1.1e-30 105.7 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain SH2 PF00017.22 NM_001271603.1_1 - 4.1e-09 36.2 0.0 6e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 NM_001271603.1_1 - 3.8e-05 23.8 1.1 5.5e-05 23.3 0.1 1.8 2 0 0 2 2 2 1 SOCS box zf-C3Hc3H PF13891.4 NM_001289439.1_1 - 1.9e-13 50.4 10.3 4.3e-13 49.3 10.3 1.6 1 0 0 1 1 1 1 Potential DNA-binding domain zf-C3Hc3H PF13891.4 NM_001289439.1_2 - 2.9e-16 59.4 5.0 2.9e-16 59.4 5.0 2.8 3 0 0 3 3 3 1 Potential DNA-binding domain zf-TRM13_CCCH PF11722.6 NM_001289439.1_2 - 0.66 9.7 9.3 3.8 7.2 0.1 4.0 4 0 0 4 4 4 0 CCCH zinc finger in TRM13 protein ALMS_motif PF15309.4 NM_145223.2_2 - 6.1e-39 133.4 11.8 6.1e-39 133.4 11.8 2.7 2 0 0 2 2 2 1 ALMS motif PRIMA1 PF16101.3 NM_145223.2_2 - 9.5 6.2 9.3 37 4.2 9.3 2.0 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 TROVE PF05731.9 NM_009351.2_2 - 3.4e-133 444.4 5.7 4.9e-133 443.8 5.7 1.2 1 0 0 1 1 1 1 TROVE domain TEP1_N PF05386.9 NM_009351.2_2 - 2.8e-68 225.0 25.2 5.9e-17 60.8 1.4 5.2 5 0 0 5 5 5 4 TEP1 N-terminal domain WD40 PF00400.30 NM_009351.2_2 - 2.1e-44 148.5 33.5 1.4e-06 28.8 0.1 17.5 18 0 0 18 18 17 10 WD domain, G-beta repeat NACHT PF05729.10 NM_009351.2_2 - 1.5e-34 119.2 0.3 3.9e-34 117.8 0.3 1.8 1 0 0 1 1 1 1 NACHT domain DUF4062 PF13271.4 NM_009351.2_2 - 4.4e-19 68.5 0.0 1e-18 67.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) ANAPC4_WD40 PF12894.5 NM_009351.2_2 - 2.5e-17 62.8 0.0 0.0076 16.4 0.0 7.8 5 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain AAA_16 PF13191.4 NM_009351.2_2 - 2.5e-06 27.8 0.6 9.7e-06 25.9 0.6 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 NM_009351.2_2 - 1.7e-05 24.9 0.0 6e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain Ge1_WD40 PF16529.3 NM_009351.2_2 - 0.00016 20.6 0.0 5.9 5.6 0.0 4.2 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 NM_009351.2_2 - 0.00077 18.1 0.8 0.2 10.1 0.0 3.0 3 0 0 3 3 3 2 Nucleoporin Nup120/160 AAA_19 PF13245.4 NM_009351.2_2 - 0.00082 19.6 0.0 0.0025 18.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain Frtz PF11768.6 NM_009351.2_2 - 0.0063 14.8 0.0 0.046 11.9 0.0 2.4 3 0 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.3 NM_009351.2_2 - 0.0095 15.2 0.0 0.21 10.7 0.0 2.8 3 0 0 3 3 3 1 WD40-like domain AAA_25 PF13481.4 NM_009351.2_2 - 0.014 14.9 0.0 0.068 12.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.4 NM_009351.2_2 - 0.1 12.2 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain tRNA-synt_1b PF00579.23 NM_027462.4_1 - 1.5e-67 227.8 0.1 1.9e-67 227.5 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Tetraspannin PF00335.18 NM_019656.3_1 - 1.1e-47 162.4 10.5 1.6e-47 161.9 10.5 1.2 1 0 0 1 1 1 1 Tetraspanin family 4HB_MCP_1 PF12729.5 NM_019656.3_1 - 0.0073 15.7 0.6 0.027 13.9 0.0 1.9 2 0 0 2 2 2 1 Four helix bundle sensory module for signal transduction Phage_holin_3_6 PF07332.9 NM_019656.3_1 - 6.5 6.7 8.0 0.64 9.9 0.4 2.5 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III bZIP_1 PF00170.19 NM_001284373.1_1 - 2.5e-12 46.6 6.5 4e-12 45.9 6.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001284373.1_1 - 1.8e-08 34.2 6.8 3.8e-08 33.2 6.8 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001284373.1_1 - 0.018 15.4 6.6 0.035 14.5 6.6 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor ATG16 PF08614.9 NM_001284373.1_1 - 0.73 9.8 9.7 1.4 8.9 9.7 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) PRP21_like_P PF12230.6 NM_001037713.4_2 - 6.4e-05 22.8 15.7 0.0034 17.1 1.2 3.5 2 1 2 4 4 4 2 Pre-mRNA splicing factor PRP21 like protein Sgf11 PF08209.9 NM_001037713.4_2 - 0.011 15.2 15.2 0.04 13.3 0.6 4.1 4 0 0 4 4 4 0 Sgf11 (transcriptional regulation protein) zf-dskA_traR PF01258.15 NM_001037713.4_2 - 9.4 6.1 11.0 0.37 10.6 0.6 3.4 4 0 0 4 4 4 0 Prokaryotic dksA/traR C4-type zinc finger Calsarcin PF05556.9 NM_021508.3_2 - 8e-102 339.7 0.0 9.5e-102 339.5 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) DUF3000 PF11452.6 NM_021508.3_3 - 0.13 11.7 1.7 0.62 9.4 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3000) Pkinase_Tyr PF07714.15 NM_008011.2_1 - 3.8e-101 337.6 0.0 4.9e-101 337.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_008011.2_1 - 3.9e-43 147.6 0.0 5.3e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.4 NM_008011.2_1 - 5.8e-33 113.2 0.0 7.4e-13 48.8 0.0 3.9 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.14 NM_008011.2_1 - 1.7e-31 108.0 0.0 1.9e-13 50.2 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_008011.2_1 - 1.8e-21 76.1 0.0 1.3e-08 34.9 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_008011.2_1 - 1.3e-20 73.2 0.0 1.6e-10 40.9 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 NM_008011.2_1 - 2.1e-14 53.4 0.6 0.0011 18.9 0.1 5.8 3 3 1 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_008011.2_1 - 0.026 14.4 1.4 0.42 10.6 0.0 3.5 4 0 0 4 4 4 0 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 NM_008011.2_1 - 0.036 14.0 0.0 12 5.9 0.0 3.0 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Kinase-like PF14531.4 NM_008011.2_1 - 0.081 12.1 0.0 0.23 10.6 0.0 1.6 2 0 0 2 2 2 0 Kinase-like EF-hand_1 PF00036.30 NM_010860.4_1 - 5.6e-13 47.3 1.1 4.4e-05 22.6 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_010860.4_1 - 2.1e-12 45.8 0.2 4.5e-06 26.1 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 NM_010860.4_1 - 2e-07 31.3 0.1 0.0083 16.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 NM_010860.4_1 - 6.7e-05 22.5 1.3 0.26 11.0 0.1 3.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_010860.4_1 - 0.0016 17.7 0.8 0.028 13.8 0.3 2.8 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.4 NM_010860.4_1 - 0.0035 17.5 0.0 0.33 11.2 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain V-set PF07686.15 NM_009514.4_2 - 6.5e-16 58.3 0.0 7.9e-16 58.0 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_009514.4_2 - 0.00083 19.8 0.0 0.0015 18.9 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_009514.4_2 - 0.0015 18.5 0.0 0.0029 17.5 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_009514.4_2 - 0.13 12.3 0.0 0.77 9.8 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin domain 7tm_1 PF00001.19 NM_001104529.1_3 - 5.7e-32 110.9 18.4 5.7e-32 110.9 18.4 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001104529.1_3 - 0.00015 21.1 11.1 0.00015 21.1 11.1 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_001104529.1_3 - 0.0093 15.6 1.6 0.016 14.8 1.6 1.3 1 0 0 1 1 1 1 Olfactory receptor Pkinase_Tyr PF07714.15 NM_010513.2_3 - 1.7e-92 309.2 0.0 2.4e-92 308.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 NM_010513.2_3 - 1.5e-56 189.2 3.2 1.9e-28 98.7 0.8 2.3 2 0 0 2 2 2 2 Receptor L domain Pkinase PF00069.23 NM_010513.2_3 - 7e-39 133.6 0.0 1e-38 133.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 NM_010513.2_3 - 5.2e-37 126.9 38.6 5.2e-37 126.9 38.6 2.4 2 0 0 2 2 2 1 Furin-like cysteine rich region fn3 PF00041.19 NM_010513.2_3 - 5.5e-16 58.6 8.9 0.0001 22.4 0.1 4.6 4 0 0 4 4 4 4 Fibronectin type III domain Kinase-like PF14531.4 NM_010513.2_3 - 0.012 14.8 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like GH3 PF03321.11 NM_031871.1_3 - 9.1e-61 206.2 0.0 1.5e-59 202.2 0.0 2.0 2 0 0 2 2 2 2 GH3 auxin-responsive promoter CD20 PF04103.13 NM_001251849.1_1 - 7.8e-17 61.6 16.9 2.1e-16 60.2 16.9 1.7 1 1 0 1 1 1 1 CD20-like family TMEM70 PF06979.10 NM_026392.1_1 - 1.6e-53 180.4 4.9 2.2e-53 180.0 4.9 1.2 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex 7tm_4 PF13853.4 NM_146278.1_1 - 2.3e-45 155.4 25.2 2.9e-45 155.0 25.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146278.1_1 - 2.8e-18 66.0 29.4 7.2e-18 64.6 29.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146278.1_1 - 5e-05 22.7 26.6 9.5e-05 21.8 26.6 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Glyco_transf_8 PF01501.18 NM_001165930.1_3 - 1.6e-66 224.4 0.0 2e-66 224.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 Hormone_1 PF00103.18 NM_010088.2_2 - 2.7e-47 161.2 0.2 3.3e-47 160.9 0.2 1.1 1 0 0 1 1 1 1 Somatotropin hormone family AIG1 PF04548.14 NM_146167.3_1 - 7.2e-80 267.2 0.6 1.2e-79 266.4 0.6 1.3 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.21 NM_146167.3_1 - 2.6e-09 37.0 0.0 5.3e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 NM_146167.3_1 - 3.6e-05 23.7 6.2 0.079 12.9 0.3 3.3 3 1 1 4 4 4 2 Dynamin family FeoB_N PF02421.16 NM_146167.3_1 - 0.00061 19.2 0.0 0.0013 18.1 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.25 NM_146167.3_1 - 0.0073 16.7 3.0 0.023 15.1 0.0 2.3 1 1 0 2 2 2 1 ABC transporter DUF258 PF03193.14 NM_146167.3_1 - 0.011 15.5 1.8 0.042 13.6 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function, DUF258 AAA_10 PF12846.5 NM_146167.3_1 - 0.013 14.3 0.3 0.2 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain SMC_N PF02463.17 NM_146167.3_1 - 0.022 14.0 0.0 0.056 12.7 0.0 1.6 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.4 NM_146167.3_1 - 0.044 13.9 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.20 NM_146167.3_1 - 0.048 13.2 0.6 1.2 8.6 0.0 2.2 1 1 1 2 2 2 0 SRP54-type protein, GTPase domain T2SSE PF00437.18 NM_146167.3_1 - 0.058 12.3 0.0 0.12 11.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Sigma54_activat PF00158.24 NM_146167.3_1 - 0.066 12.8 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain FtsK_SpoIIIE PF01580.16 NM_146167.3_1 - 0.078 12.2 0.4 0.95 8.6 0.1 2.2 2 1 0 2 2 2 0 FtsK/SpoIIIE family AAA_18 PF13238.4 NM_146167.3_1 - 0.094 13.1 0.6 5.3 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 NM_146167.3_1 - 0.096 11.8 0.4 0.35 10.0 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin Lipase_GDSL_3 PF14606.4 NM_146167.3_1 - 0.28 11.2 1.2 0.51 10.3 1.2 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF3802 PF12290.6 NM_146167.3_1 - 0.31 11.4 3.1 0.24 11.8 1.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3802) AAA_23 PF13476.4 NM_146167.3_1 - 0.48 10.8 10.9 11 6.3 7.7 2.2 2 0 0 2 2 2 0 AAA domain OmpH PF03938.12 NM_146167.3_1 - 1.1 9.1 9.0 2.3 8.1 9.0 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF87 PF01935.15 NM_146167.3_1 - 9.7 6.0 10.7 0.54 10.1 0.5 2.6 2 1 0 2 2 2 0 Domain of unknown function DUF87 zf-C2H2_4 PF13894.4 NM_028326.1_2 - 1.3e-09 37.9 23.6 0.023 15.4 2.3 5.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_028326.1_2 - 2.6e-08 33.7 28.4 0.041 14.2 0.3 5.0 4 0 0 4 4 4 4 Zinc finger, C2H2 type Dimer_Tnp_hAT PF05699.12 NM_028326.1_2 - 0.00064 19.3 0.1 0.0019 17.8 0.1 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-H2C2_2 PF13465.4 NM_028326.1_2 - 0.0054 17.0 17.4 1.2 9.6 0.2 5.4 5 0 0 5 5 5 3 Zinc-finger double domain zf-met PF12874.5 NM_028326.1_2 - 0.84 10.0 24.2 0.095 13.0 0.4 4.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type C1_2 PF03107.14 NM_028326.1_2 - 1 9.6 29.2 0.73 10.1 0.8 5.3 5 0 0 5 5 5 0 C1 domain Rib_hydrolayse PF02267.15 NM_009763.3_2 - 2.5e-98 328.2 0.0 3.3e-98 327.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosyl cyclase MRG PF05712.11 NM_001326287.1_2 - 1.4e-54 184.3 0.8 2.1e-54 183.7 0.8 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.6 NM_001326287.1_2 - 1.1e-15 57.1 0.4 2.2e-15 56.2 0.4 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Sushi PF00084.18 NM_144926.5_3 - 1.3e-43 147.3 27.3 3.9e-09 36.9 0.3 5.5 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) CUB PF00431.18 NM_144926.5_3 - 4.1e-25 88.1 0.0 4.3e-12 46.2 0.0 3.8 3 1 0 3 3 3 3 CUB domain cEGF PF12662.5 NM_144926.5_3 - 0.59 10.0 10.7 7.4 6.5 0.1 4.9 5 0 0 5 5 5 0 Complement Clr-like EGF-like HSR PF03172.11 NM_001271558.1_1 - 3.5e-24 84.7 0.0 4.8e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 HSR domain PHD PF00628.27 NM_001271558.1_1 - 6.2e-09 35.5 10.7 6.2e-09 35.5 10.7 2.0 2 0 0 2 2 2 1 PHD-finger SAND PF01342.19 NM_001271558.1_1 - 2.1e-06 27.2 0.0 4.4e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 SAND domain PHD_2 PF13831.4 NM_001271558.1_1 - 0.04 13.3 5.0 0.11 11.9 5.0 1.8 1 0 0 1 1 1 0 PHD-finger zf-PHD-like PF15446.4 NM_001271558.1_1 - 0.27 10.7 7.2 0.15 11.5 2.8 2.2 1 1 1 2 2 2 0 PHD/FYVE-zinc-finger like domain DEAD PF00270.27 NM_012008.2_1 - 4.3e-50 169.8 0.0 7.2e-50 169.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_012008.2_1 - 8.3e-31 106.5 0.0 1.6e-30 105.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_012008.2_1 - 0.0012 18.7 0.0 0.0028 17.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1435 PF07256.10 NM_012008.2_2 - 1.4 8.9 8.6 1.3 9.1 2.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1435) Vasculin PF15337.4 NM_028487.4_1 - 8.5e-42 141.8 3.2 8.5e-42 141.8 3.2 2.3 2 0 0 2 2 2 1 Vascular protein family Vasculin-like 1 DUF4444 PF14563.4 NM_028487.4_2 - 0.53 9.8 1.6 0.95 9.0 1.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4444) ANF_receptor PF01094.26 NM_001143834.1_2 - 3.5e-96 322.3 0.0 4.5e-96 321.9 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 NM_001143834.1_2 - 5e-56 190.0 26.1 5e-56 190.0 26.1 2.2 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR GluR_Homer-bdg PF10606.7 NM_001143834.1_2 - 1.2e-23 82.9 9.5 2.9e-23 81.6 9.5 1.7 1 0 0 1 1 1 1 Homer-binding domain of metabotropic glutamate receptor NCD3G PF07562.12 NM_001143834.1_2 - 5.2e-15 55.0 13.3 1.4e-14 53.7 13.3 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 NM_001143834.1_2 - 1e-09 38.4 0.0 1.9e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein Transport_MerF PF11431.6 NM_145993.5_1 - 0.08 12.7 0.3 0.15 11.8 0.3 1.4 1 0 0 1 1 1 0 Membrane transport protein MerF MBT PF02820.16 NM_145993.5_2 - 1.6e-96 316.6 3.4 5e-28 97.1 0.2 4.5 4 0 0 4 4 4 4 mbt repeat Agenet PF05641.10 NM_145993.5_2 - 0.092 13.1 0.0 0.26 11.7 0.0 1.8 1 0 0 1 1 1 0 Agenet domain P2X_receptor PF00864.17 NM_001164833.1_3 - 6.1e-147 489.3 0.3 7.5e-147 489.1 0.3 1.0 1 0 0 1 1 1 1 ATP P2X receptor Ras PF00071.20 NM_029391.2_1 - 3.9e-57 192.3 0.0 4.9e-57 191.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_029391.2_1 - 1.3e-31 109.2 0.0 1.8e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_029391.2_1 - 1.7e-13 50.3 0.0 2.4e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 NM_029391.2_1 - 0.00018 20.9 0.0 0.0033 16.9 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 NM_029391.2_1 - 0.0012 18.8 0.0 0.0019 18.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_029391.2_1 - 0.0029 16.9 0.0 0.0037 16.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.4 NM_029391.2_1 - 0.038 14.2 0.0 0.072 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.14 NM_029391.2_1 - 0.054 13.3 0.1 8.9 6.0 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function, DUF258 SRPRB PF09439.8 NM_029391.2_1 - 0.059 12.7 0.0 0.085 12.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ATPase PF06745.11 NM_029391.2_1 - 0.094 11.9 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 KaiC Septin PF00735.16 NM_029391.2_1 - 0.19 10.8 0.0 0.26 10.3 0.0 1.1 1 0 0 1 1 1 0 Septin CTC1 PF15489.4 NM_001281464.1_1 - 0 2004.4 17.8 0 2004.1 17.8 1.0 1 0 0 1 1 1 1 CST, telomere maintenance, complex subunit CTC1 CTC1_2 PF15491.4 NM_001281464.1_1 - 1.5e-05 24.2 0.0 0.00054 19.2 0.0 2.5 3 0 0 3 3 3 1 CST, telomere maintenance, complex subunit CTC1 zf-4CXXC_R1 PF10497.7 NM_001281464.1_1 - 0.15 12.2 1.9 0.39 10.9 1.9 1.6 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 MIP PF00230.18 NM_001317729.1_2 - 3.5e-72 242.7 18.1 4.9e-72 242.2 18.1 1.1 1 0 0 1 1 1 1 Major intrinsic protein 7tm_3 PF00003.20 NM_001105076.1_1 - 2.3e-49 168.1 21.4 2.3e-49 168.1 21.4 1.8 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001105076.1_1 - 6.3e-35 120.8 0.1 9.3e-35 120.2 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001105076.1_1 - 1.4e-17 63.3 12.9 3.4e-17 62.0 12.9 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Cullin_binding PF03556.13 NM_001105076.1_1 - 0.048 14.1 0.3 0.28 11.6 0.1 2.4 2 0 0 2 2 2 0 Cullin binding Ephrin_rec_like PF07699.11 NM_001105076.1_1 - 0.096 12.3 6.9 0.43 10.2 6.9 2.1 1 1 0 1 1 1 0 Putative ephrin-receptor like Med27 PF11571.6 NM_026896.5_3 - 5.4e-27 93.9 0.2 1.2e-26 92.8 0.2 1.6 1 0 0 1 1 1 1 Mediator complex subunit 27 DSS1_SEM1 PF05160.11 NM_178242.2_1 - 0.023 14.6 0.8 0.2 11.6 0.1 2.3 2 0 0 2 2 2 0 DSS1/SEM1 family Helicase_C_2 PF13307.4 NM_178309.2_2 - 1.1e-54 185.0 0.0 1.7e-54 184.4 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.13 NM_178309.2_2 - 4.7e-51 172.8 0.3 1.3e-50 171.3 0.3 1.9 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.27 NM_178309.2_2 - 9.3e-05 22.1 0.0 0.00043 20.0 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase SNF2_N PF00176.21 NM_178309.2_2 - 0.013 14.1 0.0 0.023 13.3 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain ResIII PF04851.13 NM_178309.2_2 - 0.031 14.2 0.0 5.1 6.9 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit HBB PF06777.9 NM_178309.2_2 - 0.051 13.1 0.0 0.17 11.4 0.0 1.8 2 0 0 2 2 2 0 Helical and beta-bridge domain p450 PF00067.20 NM_001100181.1_2 - 2.3e-131 438.6 0.0 2.8e-131 438.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.19 NM_183031.2_1 - 2.1e-45 154.9 16.8 3.4e-45 154.3 16.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Plant_zn_clust PF10533.7 NM_183031.2_3 - 0.045 13.6 0.5 0.11 12.3 0.5 1.6 1 0 0 1 1 1 0 Plant zinc cluster domain 7tm_1 PF00001.19 NM_029771.3_2 - 2e-37 128.8 13.3 3e-37 128.2 13.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_029771.3_2 - 0.00068 19.0 10.1 0.001 18.4 10.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx BTB PF00651.29 NM_001007222.3_3 - 2.9e-28 98.2 0.4 5.3e-28 97.3 0.1 1.6 2 0 0 2 2 2 1 BTB/POZ domain MATH PF00917.24 NM_001007222.3_3 - 4e-07 30.0 0.6 1.5e-06 28.1 0.3 1.9 2 0 0 2 2 2 1 MATH domain BACK PF07707.13 NM_001007222.3_3 - 0.00093 19.1 0.1 0.031 14.2 0.0 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch Ald_Xan_dh_C2 PF02738.16 NM_023617.2_1 - 3.1e-187 623.2 0.0 4.4e-187 622.7 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 NM_023617.2_1 - 9e-41 139.3 0.1 2.9e-40 137.7 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.15 NM_023617.2_1 - 3.9e-30 103.9 0.0 1.3e-28 99.0 0.0 2.8 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.18 NM_023617.2_1 - 5.3e-30 103.1 0.3 1.4e-29 101.7 0.3 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.20 NM_023617.2_1 - 2.3e-27 95.4 1.8 4.6e-27 94.4 1.8 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2 PF00111.25 NM_023617.2_1 - 3.4e-07 30.0 1.8 4.1e-07 29.7 0.1 2.2 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain BTB PF00651.29 NM_153165.2_2 - 2.5e-23 82.3 1.9 2.5e-23 82.3 1.9 1.6 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.13 NM_153165.2_2 - 2.9e-15 56.1 0.1 5.8e-15 55.1 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch AbLIM_anchor PF16182.3 NM_001177696.1_1 - 8.4e-112 374.6 25.3 3.8e-76 257.2 22.6 2.4 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM LIM PF00412.20 NM_001177696.1_1 - 3.5e-41 139.1 41.6 8.1e-14 51.5 2.8 4.6 4 0 0 4 4 4 4 LIM domain VHP PF02209.17 NM_001177696.1_1 - 2.7e-16 59.2 1.0 4.6e-16 58.5 1.0 1.4 1 0 0 1 1 1 1 Villin headpiece domain zf-C2H2 PF00096.24 NM_177700.4_2 - 0.16 12.3 19.0 8.2 7.0 0.4 5.6 3 1 1 4 4 4 0 Zinc finger, C2H2 type zf-DHHC PF01529.18 NM_146073.3_2 - 1e-36 125.9 7.7 1e-36 125.9 7.7 2.3 3 0 0 3 3 3 1 DHHC palmitoyltransferase BTB PF00651.29 NM_001165997.1_1 - 1.1e-31 109.1 0.9 1.8e-31 108.5 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain MATH PF00917.24 NM_001165997.1_3 - 4.9e-05 23.3 0.0 8.8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 MATH domain PI-PLC-X PF00388.17 NM_008874.4_2 - 1.3e-56 190.1 0.0 2.4e-56 189.2 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PLC-beta_C PF08703.8 NM_008874.4_2 - 8.4e-54 182.1 33.1 8.4e-54 182.1 33.1 2.2 2 0 0 2 2 2 1 PLC-beta C terminal PI-PLC-Y PF00387.17 NM_008874.4_2 - 8e-42 142.1 0.6 8e-42 142.1 0.6 3.2 4 0 0 4 4 4 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.9 NM_008874.4_2 - 2.7e-09 37.3 0.0 1e-08 35.4 0.0 2.0 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.28 NM_008874.4_2 - 4.2e-07 30.1 0.0 1e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain DUF1154 PF06631.9 NM_008874.4_2 - 0.001 18.9 0.4 0.001 18.9 0.4 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1154) EMI PF07546.11 NM_024474.2_2 - 2.1e-17 63.5 11.0 2.1e-17 63.5 11.0 1.9 2 0 0 2 2 2 1 EMI domain Collagen PF01391.16 NM_024474.2_2 - 1.9e-15 56.2 63.0 4.7e-08 32.5 29.4 4.0 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Glyco_transf_10 PF00852.17 NM_001177366.1_2 - 3.3e-55 186.4 0.0 4.2e-55 186.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 NM_001177366.1_2 - 3.7e-35 120.6 0.0 6.2e-35 119.9 0.0 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal CARD_2 PF16739.3 NM_027835.3_2 - 1e-39 134.3 0.1 1.9e-18 66.1 0.0 2.6 2 0 0 2 2 2 2 Caspase recruitment domain RIG-I_C-RD PF11648.6 NM_027835.3_2 - 1.6e-38 131.4 1.9 4.6e-38 130.0 1.9 1.8 1 0 0 1 1 1 1 C-terminal domain of RIG-I Helicase_C PF00271.29 NM_027835.3_2 - 9.2e-20 70.9 2.0 9.7e-19 67.7 0.3 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_027835.3_2 - 4.6e-19 68.9 0.5 1.2e-18 67.6 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.27 NM_027835.3_2 - 5e-17 62.1 0.0 1.2e-16 60.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase CARD PF00619.19 NM_027835.3_2 - 4.8e-16 58.4 0.1 3.7e-12 46.0 0.1 2.6 2 0 0 2 2 2 2 Caspase recruitment domain DUF3638 PF12340.6 NM_027835.3_2 - 0.026 13.7 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) AAA_22 PF13401.4 NM_027835.3_2 - 0.035 14.2 0.6 0.28 11.3 0.1 2.7 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.4 NM_027835.3_2 - 0.07 13.3 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain Mtc PF03820.15 NM_027324.5_1 - 8.6e-150 497.9 1.4 1.1e-149 497.6 1.4 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier EF-hand_11 PF08976.9 NM_029946.4_2 - 5e-92 303.6 16.5 1.1e-65 218.9 0.1 10.8 11 0 0 11 11 11 6 EF-hand domain EF-hand_7 PF13499.4 NM_029946.4_2 - 8.7e-43 144.5 32.0 6.9e-08 32.7 0.1 12.6 11 1 0 11 11 11 9 EF-hand domain pair EF-hand_6 PF13405.4 NM_029946.4_2 - 4.8e-41 135.1 21.4 0.00016 21.2 0.0 16.0 18 0 0 18 18 18 10 EF-hand domain EF-hand_1 PF00036.30 NM_029946.4_2 - 3.4e-37 123.1 13.9 0.0021 17.3 0.0 16.8 18 0 0 18 18 18 8 EF hand EF-hand_8 PF13833.4 NM_029946.4_2 - 6.4e-25 86.6 1.5 0.0065 16.1 0.0 10.2 10 1 1 11 11 11 7 EF-hand domain pair EF-hand_5 PF13202.4 NM_029946.4_2 - 6.1e-16 57.0 9.4 0.001 18.3 0.0 9.3 10 0 0 10 10 10 3 EF hand GPHH PF16905.3 NM_029946.4_2 - 5.6e-07 29.1 0.0 0.6 9.8 0.0 5.8 5 0 0 5 5 5 2 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_9 PF14658.4 NM_029946.4_2 - 1.9e-05 24.8 2.5 4.5 7.5 0.0 6.5 9 0 0 9 9 9 1 EF-hand domain B5 PF03484.13 NM_029946.4_2 - 0.13 12.5 0.0 1.3 9.2 0.0 2.8 2 0 0 2 2 2 0 tRNA synthetase B5 domain Uteroglobin PF01099.15 NM_029946.4_2 - 0.53 10.4 3.3 58 3.9 0.0 4.5 4 0 0 4 4 4 0 Uteroglobin family YL1_C PF08265.9 NM_172625.2_1 - 2.1e-10 40.1 0.0 4.2e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DUF5077 PF16871.3 NM_172625.2_1 - 0.12 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5077) Interferon PF00143.17 NM_001085532.3_2 - 1.9e-26 93.0 0.0 3.1e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Interferon alpha/beta domain Ank_2 PF12796.5 NM_001164441.1_2 - 3.2e-16 59.5 0.0 8.5e-12 45.4 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_001164441.1_2 - 2.2e-15 56.3 1.1 2e-05 24.7 0.0 4.6 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_001164441.1_2 - 1.7e-14 53.8 0.1 2.8e-07 30.8 0.1 3.9 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001164441.1_2 - 2.7e-08 33.3 0.5 0.13 12.7 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.28 NM_001164441.1_2 - 4e-06 26.9 0.0 0.00092 19.4 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ig_3 PF13927.4 NM_028078.3_3 - 6.4e-06 26.6 0.2 1.2e-05 25.6 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_028078.3_3 - 1.7e-05 24.6 0.0 3.5e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Shisa PF13908.4 NM_028078.3_3 - 1.8e-05 24.9 1.2 2.3e-05 24.6 0.0 1.7 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator ig PF00047.23 NM_028078.3_3 - 7.7e-05 22.7 0.3 0.00019 21.4 0.3 1.7 1 1 0 1 1 1 1 Immunoglobulin domain WBP-1 PF11669.6 NM_028078.3_3 - 0.00054 20.4 0.0 0.0013 19.2 0.0 1.6 1 0 0 1 1 1 1 WW domain-binding protein 1 MAP17 PF15807.3 NM_028078.3_3 - 0.00085 19.4 0.0 0.0024 18.0 0.0 1.7 2 0 0 2 2 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Orthoreo_P10 PF07204.9 NM_028078.3_3 - 0.0065 16.3 0.1 0.013 15.3 0.1 1.5 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 LYRIC PF15686.3 NM_028078.3_3 - 0.007 15.8 0.0 0.007 15.8 0.0 1.4 2 0 0 2 2 1 1 Lysine-rich CEACAM1 co-isolated protein family EphA2_TM PF14575.4 NM_028078.3_3 - 0.0081 16.8 0.0 0.024 15.3 0.0 1.8 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Rax2 PF12768.5 NM_028078.3_3 - 0.013 15.0 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity TMEM154 PF15102.4 NM_028078.3_3 - 0.015 15.1 1.8 0.028 14.2 0.5 2.1 1 1 1 2 2 2 0 TMEM154 protein family Ig_2 PF13895.4 NM_028078.3_3 - 0.023 14.9 0.1 0.055 13.7 0.1 1.6 1 0 0 1 1 1 0 Immunoglobulin domain TMIE PF16038.3 NM_028078.3_3 - 0.027 14.2 0.3 0.069 12.9 0.3 1.7 1 0 0 1 1 1 0 TMIE protein TMEM52 PF14979.4 NM_028078.3_3 - 0.028 14.2 0.1 0.093 12.5 0.0 2.0 2 0 0 2 2 2 0 Transmembrane 52 tRNA_anti-like PF12869.5 NM_028078.3_3 - 0.029 14.0 0.0 0.067 12.8 0.0 1.5 1 0 0 1 1 1 0 tRNA_anti-like IncA PF04156.12 NM_028078.3_3 - 0.048 13.3 0.0 0.072 12.7 0.0 1.3 1 0 0 1 1 1 0 IncA protein V-set PF07686.15 NM_028078.3_3 - 0.06 13.4 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin V-set domain Sigma_reg_N PF13800.4 NM_028078.3_3 - 0.063 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Sigma factor regulator N-terminal ETRAMP PF09716.8 NM_028078.3_3 - 0.073 13.0 0.0 0.073 13.0 0.0 2.4 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) FAM176 PF14851.4 NM_028078.3_3 - 0.085 12.4 0.2 0.23 11.0 0.0 1.7 2 0 0 2 2 2 0 FAM176 family DUF4834 PF16118.3 NM_028078.3_3 - 0.1 13.4 0.0 0.25 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SIT PF15330.4 NM_028078.3_3 - 0.11 12.8 0.7 0.7 10.2 0.6 2.1 1 1 1 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT DUF843 PF05814.9 NM_028078.3_3 - 0.23 11.4 3.3 0.29 11.0 0.0 2.4 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) His_Phos_2 PF00328.20 NM_207668.2_1 - 4.2e-33 115.1 0.0 2e-31 109.6 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) NICE-1 PF15845.3 NM_028798.3_1 - 1.1e-31 109.2 73.1 1.1e-31 109.2 73.1 2.1 2 1 0 2 2 2 1 Cysteine-rich C-terminal 1 family 7tm_4 PF13853.4 NM_146274.1_1 - 5.4e-43 147.6 18.9 6.4e-43 147.3 18.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146274.1_1 - 2.6e-22 79.2 18.7 8.7e-22 77.5 18.7 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_146777.1_1 - 3.6e-47 161.3 23.4 4.8e-47 160.9 23.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146777.1_1 - 4.5e-22 78.4 24.6 1.1e-21 77.2 24.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3810 PF12725.5 NM_146777.1_1 - 7.2 5.7 12.4 0.14 11.4 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Bcl-2 PF00452.17 NM_177410.3_1 - 1.1e-31 109.2 0.1 1.8e-31 108.6 0.1 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.15 NM_177410.3_1 - 1.8e-13 49.8 0.3 3.7e-13 48.8 0.3 1.5 1 0 0 1 1 1 1 Bcl-2 homology region 4 Bcl-2_3 PF15286.4 NM_177410.3_1 - 0.019 15.5 0.0 0.033 14.7 0.0 1.3 1 0 0 1 1 1 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like TEA PF01285.16 NM_011567.2_3 - 2.5e-25 89.4 0.1 4.1e-25 88.7 0.1 1.2 1 0 0 1 1 1 1 TEA/ATTS domain family zf-H2C2_2 PF13465.4 NM_146259.3_2 - 1.2e-83 271.9 115.8 9.5e-08 32.0 0.4 18.9 19 0 0 19 19 19 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_146259.3_2 - 1.5e-70 229.7 108.1 9.4e-06 25.7 0.4 16.5 16 0 0 16 16 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_146259.3_2 - 5.7e-55 179.0 105.7 0.00011 22.6 0.8 16.7 16 0 0 16 16 16 16 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_146259.3_2 - 2.2e-23 81.8 39.9 0.08 13.1 0.0 15.4 16 0 0 16 16 16 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_146259.3_2 - 7.4e-23 79.9 89.1 0.0013 18.5 1.4 16.2 16 0 0 16 16 16 10 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_146259.3_2 - 0.00033 20.2 70.0 0.012 15.2 0.1 13.5 14 0 0 14 14 14 5 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 NM_146259.3_2 - 0.00079 19.4 77.2 0.023 14.7 1.9 12.4 4 2 10 15 15 15 6 Zinc ribbon domain zf-C2HC_2 PF13913.4 NM_146259.3_2 - 0.021 14.6 1.1 0.021 14.6 1.1 11.9 13 0 0 13 13 12 0 zinc-finger of a C2HC-type BDHCT_assoc PF16204.3 NM_146259.3_2 - 0.035 13.6 3.2 13 5.2 0.2 3.2 3 0 0 3 3 3 0 BDHCT-box associated domain on Bloom syndrome protein DUF3268 PF11672.6 NM_146259.3_2 - 0.038 14.2 22.0 3.2 8.0 0.1 6.7 7 0 0 7 7 7 0 zinc-finger-containing domain ADK_lid PF05191.12 NM_146259.3_2 - 0.054 13.4 29.9 1.1 9.2 0.8 8.5 6 3 4 10 10 10 0 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 NM_146259.3_2 - 0.22 12.2 44.3 0.6 10.8 0.1 8.3 6 2 2 8 8 8 0 zinc-ribbon family zf-LYAR PF08790.9 NM_146259.3_2 - 0.27 11.1 43.0 4.1 7.3 0.1 12.0 14 0 0 14 14 14 0 LYAR-type C2HC zinc finger zf-met PF12874.5 NM_146259.3_2 - 1.1 9.6 78.3 0.29 11.4 0.4 14.2 15 0 0 15 15 15 0 Zinc-finger of C2H2 type YhfH PF14149.4 NM_146259.3_2 - 1.3 8.9 24.4 94 3.0 0.0 9.7 10 0 0 10 10 10 0 YhfH-like protein zf-AN1 PF01428.14 NM_146259.3_2 - 3.6 7.7 71.8 5.4 7.1 0.3 15.4 15 1 0 16 16 16 0 AN1-like Zinc finger HypA PF01155.17 NM_146259.3_2 - 7.1 6.6 48.2 7.2 6.5 2.4 8.4 3 2 2 5 5 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA OCC1 PF15506.4 NM_001145198.1_2 - 8.1e-33 112.2 5.1 1.2e-32 111.7 5.1 1.3 1 0 0 1 1 1 1 OCC1 family 7tm_4 PF13853.4 NM_146710.1_1 - 1.1e-49 169.5 11.3 1.4e-49 169.2 11.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146710.1_1 - 1.4e-17 63.7 18.2 3.7e-17 62.3 18.2 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146710.1_1 - 8e-05 22.0 10.0 0.00025 20.4 10.0 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TrbC PF04956.11 NM_146710.1_1 - 0.017 15.2 0.8 0.043 13.9 0.8 1.8 1 0 0 1 1 1 0 TrbC/VIRB2 family 7TM_GPCR_Srx PF10328.7 NM_146710.1_1 - 0.31 10.2 5.1 0.58 9.3 4.0 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.7 NM_146710.1_1 - 1.1 8.6 9.0 0.037 13.4 3.0 1.7 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc YGGT PF02325.15 NM_146710.1_1 - 1.2 9.4 5.0 7.9 6.8 0.2 2.9 3 0 0 3 3 3 0 YGGT family LRR_8 PF13855.4 NM_007542.5_3 - 1.8e-32 110.8 23.7 1.9e-13 49.8 1.9 5.1 4 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.5 NM_007542.5_3 - 2.2e-13 50.0 20.3 9.5e-05 22.5 0.9 6.2 3 2 4 7 7 7 6 Leucine Rich repeats (2 copies) LRRNT PF01462.16 NM_007542.5_3 - 1.5e-10 40.3 2.6 1.5e-10 40.3 2.6 4.3 5 0 0 5 5 5 2 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 NM_007542.5_3 - 9.1e-09 34.9 7.3 0.00061 19.2 0.6 3.3 1 1 2 3 3 3 2 Leucine-rich repeat LRR_5 PF13306.4 NM_007542.5_3 - 0.0001 22.1 0.0 0.0011 18.8 0.0 2.2 1 1 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_1 PF00560.31 NM_007542.5_3 - 0.13 12.7 18.8 14 6.5 0.4 8.4 7 2 0 7 7 7 0 Leucine Rich Repeat Neurensin PF14927.4 NM_009513.2_2 - 1.4e-49 167.1 0.1 2e-49 166.6 0.1 1.2 1 0 0 1 1 1 1 Neurensin ABC_trans_CmpB PF06541.9 NM_178745.4_1 - 2.2e-08 34.3 11.0 3.8e-08 33.6 11.0 1.3 1 0 0 1 1 1 1 Putative ABC-transporter type IV DNA_pol_A_exo1 PF01612.18 NM_016699.2_3 - 1.8e-49 167.7 0.5 2.8e-49 167.1 0.5 1.3 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.10 NM_016699.2_3 - 3.4e-23 82.0 0.0 1.2e-22 80.2 0.0 2.0 1 0 0 1 1 1 1 PMC2NT (NUC016) domain HRDC PF00570.21 NM_016699.2_3 - 3.4e-14 52.4 0.4 8.1e-13 48.0 0.0 2.5 2 0 0 2 2 2 1 HRDC domain RRM_1 PF00076.20 NM_025682.3_2 - 4e-32 109.7 0.1 1.8e-15 56.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.9 NM_025682.3_2 - 1.6e-28 98.5 2.4 1.6e-28 98.5 2.4 2.0 2 0 0 2 2 2 1 NOPS (NUC059) domain RRM_7 PF16367.3 NM_025682.3_2 - 0.00091 19.2 0.0 0.0051 16.8 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif Aldedh PF00171.20 NM_025682.3_2 - 2.5 6.4 4.5 3.7 5.8 4.5 1.2 1 0 0 1 1 1 0 Aldehyde dehydrogenase family BAR PF03114.16 NM_001252471.1_2 - 7.2e-78 261.4 5.7 8.6e-78 261.1 5.7 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.7 NM_001252471.1_2 - 2e-11 43.4 5.1 6.4e-10 38.5 1.8 2.1 2 0 0 2 2 2 2 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.3 NM_001252471.1_2 - 0.013 15.1 4.7 0.031 13.8 4.6 1.8 1 1 0 1 1 1 0 BAR domain of APPL family Prefoldin_3 PF13758.4 NM_001252471.1_2 - 0.13 12.2 3.3 0.34 10.9 2.0 2.0 2 0 0 2 2 2 0 Prefoldin subunit SH3_1 PF00018.26 NM_001252471.1_3 - 1.8e-13 49.7 0.1 2.9e-13 49.0 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001252471.1_3 - 9.2e-13 47.7 0.1 1.4e-12 47.1 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001252471.1_3 - 4.5e-12 45.3 0.0 7.1e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Tropomyosin PF00261.18 NM_001164250.1_1 - 2.3e-92 308.6 83.9 1.2e-88 296.3 60.5 2.1 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 NM_001164250.1_1 - 2.2e-40 138.0 69.1 9.3e-37 126.2 39.8 3.2 2 1 1 3 3 3 2 Tropomyosin like CLZ PF16526.3 NM_001164250.1_1 - 1e-07 32.1 49.4 0.0001 22.5 10.5 4.7 2 2 2 4 4 4 4 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMF_DNA_bd PF12329.6 NM_001164250.1_1 - 0.001 18.9 13.8 0.001 18.9 13.8 5.8 2 1 3 5 5 5 3 TATA element modulatory factor 1 DNA binding Laminin_II PF06009.10 NM_001164250.1_1 - 0.0011 18.8 37.6 0.079 12.8 5.0 4.2 1 1 4 5 5 5 5 Laminin Domain II IncA PF04156.12 NM_001164250.1_1 - 0.0039 16.9 23.8 0.0039 16.9 23.8 2.7 1 1 2 3 3 3 1 IncA protein ERM PF00769.17 NM_001164250.1_1 - 0.87 9.2 70.5 4.6 6.9 25.1 3.1 1 1 2 3 3 3 0 Ezrin/radixin/moesin family AAA_13 PF13166.4 NM_001164250.1_1 - 1.2 7.6 44.9 1.9 6.9 27.5 2.1 1 1 1 2 2 2 0 AAA domain DUF1664 PF07889.10 NM_001164250.1_1 - 1.4 8.8 30.2 0.17 11.7 4.6 3.7 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) SNARE PF05739.17 NM_001164250.1_1 - 1.7 8.6 8.8 3.7 7.5 0.1 4.4 4 1 1 5 5 5 0 SNARE domain Fib_alpha PF08702.8 NM_001164250.1_1 - 4.9 7.2 30.7 0.29 11.2 8.7 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family COG2 PF06148.9 NM_001164250.1_1 - 5.1 7.0 29.1 0.74 9.8 5.8 4.2 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Flagellin_N PF00669.18 NM_001164250.1_1 - 8.6 6.3 21.5 2.1 8.3 5.4 3.9 1 1 2 4 4 4 0 Bacterial flagellin N-terminal helical region Laminin_I PF06008.12 NM_001164250.1_1 - 8.6 5.8 55.8 0.12 11.9 15.7 3.2 1 1 2 3 3 3 0 Laminin Domain I DUF745 PF05335.11 NM_001164250.1_1 - 9.4 5.8 48.3 0.91 9.1 13.8 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF745) ADIP PF11559.6 NM_001164250.1_1 - 9.5 6.1 50.8 0.71 9.8 5.5 4.2 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.7 NM_001164250.1_1 - 9.7 6.1 65.4 3.2 7.6 31.5 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Dynein_light PF01221.16 NM_017470.2_1 - 2.5e-26 91.7 0.1 3.7e-26 91.1 0.1 1.2 1 0 0 1 1 1 1 Dynein light chain type 1 DUF3109 PF11307.6 NM_017470.2_1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3109) zf-CCCH PF00642.22 NM_175341.4_2 - 2.1e-09 36.9 19.1 0.00094 18.9 0.6 4.7 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 NM_175341.4_2 - 0.0004 20.5 15.3 0.0066 16.6 0.6 3.1 3 0 0 3 3 3 2 Zinc-finger containing family zf-CCCH_2 PF14608.4 NM_175341.4_2 - 0.0038 17.5 24.1 1.1 9.7 1.4 5.3 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger Torus PF16131.3 NM_175341.4_2 - 0.48 11.0 19.4 1.3 9.7 0.2 4.3 2 2 2 4 4 4 0 Torus domain MRG PF05712.11 NM_001163833.1_3 - 2.2e-57 193.4 0.0 3e-57 193.0 0.0 1.1 1 0 0 1 1 1 1 MRG CX9C PF16860.3 NM_007878.2_2 - 0.2 11.6 0.1 0.2 11.6 0.1 2.0 2 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, 7tm_1 PF00001.19 NM_007878.2_3 - 4.5e-70 235.8 0.1 6.4e-70 235.3 0.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_007878.2_3 - 6.6e-11 41.9 6.1 3.7e-07 29.6 2.5 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_007878.2_3 - 2.4e-06 27.4 5.1 1.2e-05 25.1 0.7 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 NM_007878.2_3 - 0.00044 19.5 3.7 0.0018 17.5 2.2 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx IncA PF04156.12 NM_007878.2_3 - 0.36 10.5 3.1 0.66 9.6 3.1 1.4 1 0 0 1 1 1 0 IncA protein HCV_NS4a PF01006.18 NM_007878.2_3 - 3.2 7.4 7.3 8.8 6.0 1.3 2.5 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a Peptidase_M2 PF01401.16 NM_001101453.2_1 - 5.3e-243 807.7 2.4 6.2e-243 807.5 2.4 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme Cse1 PF08506.8 NM_001101453.2_1 - 0.014 14.1 0.8 0.014 14.1 0.8 1.8 2 0 0 2 2 2 0 Cse1 DUF4131 PF13567.4 NM_001101453.2_1 - 0.031 13.8 0.6 0.062 12.8 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) CopD PF05425.11 NM_001101453.2_1 - 0.039 14.2 0.9 4.4 7.6 0.0 2.7 3 0 0 3 3 3 0 Copper resistance protein D Complex1_LYR_2 PF13233.4 NM_001077713.1_1 - 1.4e-17 64.1 0.1 1.8e-17 63.7 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.13 NM_001077713.1_1 - 9.6e-07 28.6 0.4 1.6e-06 27.9 0.1 1.5 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Glycos_transf_2 PF00535.24 NM_198306.3_3 - 6.9e-24 84.4 0.0 1.1e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 NM_198306.3_3 - 1.2e-19 70.7 0.0 2.1e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 NM_198306.3_3 - 0.05 13.1 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase PDZ PF00595.22 NM_027726.1_3 - 2.6e-39 133.3 3.1 1e-10 41.6 0.2 4.5 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) Takusan PF04822.11 NM_027726.1_3 - 2.5e-31 107.3 0.2 2.5e-31 107.3 0.2 5.2 4 2 2 6 6 6 1 Takusan dbPDZ_assoc PF16610.3 NM_027726.1_3 - 1.4e-23 82.7 8.2 1.4e-23 82.7 8.2 3.8 3 0 0 3 3 3 1 Unstructured region between two PDZ domains on Dlg5 PDZ_2 PF13180.4 NM_027726.1_3 - 5.3e-23 81.0 0.1 9.9e-06 25.7 0.0 4.6 4 0 0 4 4 4 4 PDZ domain Guanylate_kin PF00625.19 NM_027726.1_3 - 1.5e-14 54.0 0.5 1.5e-14 54.0 0.5 3.1 2 0 0 2 2 2 1 Guanylate kinase SH3_2 PF07653.15 NM_027726.1_3 - 0.035 13.6 0.0 0.093 12.3 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain DUF4516 PF14990.4 NM_001135569.1_2 - 4.4e-25 87.0 1.6 8.9e-25 86.0 1.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4516) His_Phos_1 PF00300.20 NM_023418.2_1 - 3.9e-34 117.9 0.1 2.3e-26 92.6 0.1 2.2 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) TEX13 PF15186.4 NM_031381.2_2 - 3.6e-61 205.1 2.7 5.4e-61 204.5 2.7 1.3 1 0 0 1 1 1 1 Testis-expressed sequence 13 protein family zf-CCCH PF00642.22 NM_001282024.1_1 - 0.0002 21.1 7.2 0.0002 21.1 7.2 2.1 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.4 NM_001164569.1_2 - 8e-12 44.7 12.5 8e-12 44.7 12.5 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Armet PF10208.7 NM_001164569.1_2 - 2.6e-05 24.1 4.5 0.068 13.0 0.6 2.8 2 1 1 3 3 3 2 Degradation arginine-rich protein for mis-folding SAP PF02037.25 NM_001164569.1_2 - 0.0013 18.3 0.1 0.44 10.2 0.1 2.5 2 0 0 2 2 2 2 SAP domain Prok-RING_4 PF14447.4 NM_001164569.1_2 - 0.0018 18.0 12.2 0.0018 18.0 12.2 2.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 FYVE PF01363.19 NM_001164569.1_2 - 0.0031 17.5 7.4 0.0031 17.5 7.4 2.7 2 0 0 2 2 2 1 FYVE zinc finger HeH PF12949.5 NM_001164569.1_2 - 0.048 13.3 0.1 6.4 6.5 0.0 2.5 2 0 0 2 2 2 0 HeH/LEM domain FYVE_2 PF02318.14 NM_001164569.1_2 - 3.5 7.7 15.8 0.068 13.3 6.2 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger NTP_transf_2 PF01909.21 NM_198600.2_1 - 3.1e-17 62.5 0.0 5.9e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.17 NM_198600.2_1 - 1.5e-15 57.0 0.0 2.8e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase Endosulfine PF04667.15 NM_021548.4_3 - 8e-09 35.4 1.4 1.3e-08 34.7 1.4 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Rhomboid_SP PF12595.6 NM_001291818.1_1 - 1.8e-53 181.0 0.9 2.9e-53 180.3 0.9 1.3 1 0 0 1 1 1 1 Rhomboid serine protease Rhomboid PF01694.20 NM_001291818.1_1 - 1.2e-28 99.8 8.9 1.2e-28 99.8 8.9 1.6 2 0 0 2 2 2 1 Rhomboid family Rhomboid_SP PF12595.6 NM_001291818.1_3 - 1.2e-29 103.0 0.4 2e-29 102.4 0.4 1.2 1 0 0 1 1 1 1 Rhomboid serine protease DUF775 PF05603.10 NM_001291288.1_3 - 1.3e-53 181.4 0.1 2e-53 180.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF775) DUF3915 PF13054.4 NM_001311790.1_1 - 0.12 12.2 6.5 0.21 11.4 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 NM_001311790.1_1 - 0.19 12.2 11.9 0.31 11.5 11.9 1.2 1 0 0 1 1 1 0 FAM27 D and E protein family BES1_N PF05687.11 NM_001311790.1_1 - 2.6 8.3 4.2 4.1 7.6 4.2 1.2 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal CathepsinC_exc PF08773.9 NM_001311790.1_2 - 1.9e-27 95.8 0.1 3.5e-27 94.9 0.1 1.4 1 0 0 1 1 1 1 Cathepsin C exclusion domain DUF3915 PF13054.4 NM_001311790.1_2 - 0.00055 19.8 2.9 0.001 18.9 2.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) FAM27 PF15832.3 NM_001311790.1_2 - 0.0013 19.1 11.3 0.0023 18.3 11.3 1.3 1 0 0 1 1 1 1 FAM27 D and E protein family Atrophin-1 PF03154.13 NM_001311790.1_2 - 0.71 7.9 10.7 0.95 7.5 10.7 1.0 1 0 0 1 1 1 0 Atrophin-1 family PRP38_assoc PF12871.5 NM_001311790.1_2 - 2 8.9 12.1 3.5 8.1 12.1 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term FAM27 PF15832.3 NM_001311790.1_3 - 0.0015 18.9 7.6 0.0047 17.3 7.7 1.6 2 0 0 2 2 2 1 FAM27 D and E protein family DUF3915 PF13054.4 NM_001311790.1_3 - 0.044 13.6 3.8 0.076 12.9 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 NM_001311790.1_3 - 1.2 7.2 10.8 1.7 6.7 10.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family EABR PF12180.6 NM_028760.2_2 - 6.4e-18 63.9 1.7 6.4e-18 63.9 1.7 2.1 2 0 0 2 2 2 1 TSG101 and ALIX binding domain of CEP55 HTH_34 PF13601.4 NM_028760.2_2 - 0.051 13.6 2.5 0.1 12.7 0.2 2.6 2 0 0 2 2 2 0 Winged helix DNA-binding domain zf-C2H2_3 PF13878.4 NM_028760.2_2 - 0.094 12.4 0.4 0.2 11.4 0.4 1.5 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO Golgin_A5 PF09787.7 NM_028760.2_2 - 3.6 6.8 60.8 0.34 10.2 16.3 3.3 1 1 2 3 3 3 0 Golgin subfamily A member 5 Reo_sigmaC PF04582.10 NM_028760.2_2 - 9 5.5 11.6 2.1 7.6 0.7 2.9 2 1 1 3 3 3 0 Reovirus sigma C capsid protein DHR-2 PF06920.11 NM_001128307.1_3 - 3.5e-204 679.2 8.4 8.9e-204 677.9 8.4 1.7 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.4 NM_001128307.1_3 - 1.1e-53 181.9 0.0 2.3e-53 180.8 0.0 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 NM_001128307.1_3 - 2.7e-33 114.1 0.1 6.5e-33 112.8 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.27 NM_001128307.1_3 - 1.3e-13 51.3 0.2 3.4e-13 49.9 0.2 1.8 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 NM_001128307.1_3 - 0.00033 20.9 0.1 0.0013 19.0 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.4 NM_001128307.1_3 - 0.073 13.2 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Toxin_16 PF07945.9 NM_174995.3_1 - 0.033 14.0 3.0 0.13 12.0 3.0 2.1 1 0 0 1 1 1 0 Janus-atracotoxin MAPEG PF01124.16 NM_174995.3_2 - 1.4e-16 60.5 6.1 1.8e-16 60.1 6.1 1.1 1 0 0 1 1 1 1 MAPEG family 7tm_4 PF13853.4 NM_001011761.1_1 - 5.7e-50 170.5 15.6 7.8e-50 170.0 15.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011761.1_1 - 5.9e-17 61.7 18.4 3.8e-16 59.0 18.4 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Tom7 PF08038.10 NM_025394.3_1 - 5.3e-14 51.5 0.0 9.5e-14 50.7 0.0 1.4 1 0 0 1 1 1 1 TOM7 family V1R PF03402.12 NM_001166843.1_1 - 7e-20 71.6 7.6 9.3e-20 71.2 7.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001166843.1_1 - 1.9e-12 46.8 12.6 2.5e-12 46.4 12.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001166843.1_1 - 5.2e-05 22.5 12.4 6.5e-05 22.2 12.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Vpu PF00558.17 NM_001166843.1_1 - 0.14 11.8 0.3 3.7 7.2 0.1 2.3 2 0 0 2 2 2 0 Vpu protein Ski_Sno PF02437.15 NM_001038610.2_1 - 1.7e-38 130.6 0.1 3.1e-38 129.7 0.1 1.5 1 0 0 1 1 1 1 SKI/SNO/DAC family Methyltr_RsmB-F PF01189.15 NM_001302833.1_3 - 4.6e-07 29.5 0.9 2.1e-06 27.4 0.8 1.9 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F 7tm_3 PF00003.20 NM_001104639.1_1 - 8.2e-59 199.1 32.5 1.9e-58 197.9 32.5 1.6 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001104639.1_1 - 4.3e-32 111.5 0.0 6.9e-32 110.8 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001104639.1_1 - 4.4e-20 71.3 11.5 8.7e-20 70.3 11.5 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Reg_prop PF07494.9 NM_001104639.1_1 - 0.14 12.3 1.5 0.51 10.6 0.1 2.7 2 0 0 2 2 2 0 Two component regulator propeller 7tm_4 PF13853.4 NM_146875.2_1 - 1.2e-46 159.5 23.3 1.6e-46 159.2 23.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146875.2_1 - 9.2e-20 70.9 25.1 9.2e-20 70.9 25.1 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) ProSAAS PF07259.10 NM_013892.3_2 - 1.3e-106 354.5 26.4 1.3e-106 354.5 26.4 2.0 2 0 0 2 2 2 1 ProSAAS precursor RHD_DNA_bind PF00554.20 NM_023699.3_3 - 5.8e-21 75.0 0.1 1.3e-20 73.9 0.1 1.6 1 1 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 NM_023699.3_3 - 2.8e-19 68.9 0.0 4.3e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Rel homology dimerisation domain TIG PF01833.22 NM_023699.3_3 - 2.2e-06 27.5 0.0 4.8e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 IPT/TIG domain SAG PF04092.11 NM_023699.3_3 - 0.16 12.6 0.0 0.43 11.2 0.0 1.6 2 0 0 2 2 2 0 SRS domain PNP_UDP_1 PF01048.18 NM_013632.4_2 - 6.2e-52 176.1 0.1 7.9e-52 175.7 0.1 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily G-alpha PF00503.18 NM_019690.3_1 - 4.1e-05 22.8 0.0 5.6e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit NESP55 PF06390.10 NM_019690.3_2 - 3.6e-153 508.3 40.2 4.4e-153 508.0 40.2 1.1 1 0 0 1 1 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) RbcS PF12338.6 NM_001139512.1_1 - 0.53 10.4 4.2 0.69 10.0 2.7 1.9 2 0 0 2 2 2 0 Ribulose-1,5-bisphosphate carboxylase small subunit RRM_1 PF00076.20 NM_001139512.1_2 - 4.9e-12 45.4 0.0 7.7e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001139512.1_2 - 0.0066 15.9 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.9 NM_001139512.1_2 - 0.023 15.2 8.3 0.052 14.1 8.3 1.6 1 0 0 1 1 1 0 Glycine rich protein family Herpes_capsid PF06112.9 NM_001139512.1_2 - 8.6 6.3 12.0 14 5.5 12.0 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein UCH PF00443.27 NM_144937.4_2 - 3.9e-59 200.1 0.2 5.5e-59 199.6 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_144937.4_2 - 4.8e-20 72.3 0.0 3.8e-19 69.3 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 NM_144937.4_2 - 1.1e-19 70.4 13.7 1.1e-19 70.4 13.7 3.0 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein 7tm_1 PF00001.19 NM_008773.4_3 - 1.3e-36 126.1 23.4 2.6e-36 125.1 23.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) WH1 PF00568.21 NM_001083120.2_3 - 4e-39 132.9 0.2 6.8e-39 132.1 0.2 1.3 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 NM_001083120.2_3 - 1.2e-16 59.8 3.5 2e-16 59.1 3.5 1.3 1 0 0 1 1 1 1 VASP tetramerisation domain Ran_BP1 PF00638.16 NM_001083120.2_3 - 0.0049 17.0 0.0 0.0082 16.3 0.0 1.3 1 0 0 1 1 1 1 RanBP1 domain Lectin_C PF00059.19 NM_001014997.1_1 - 2.6e-16 60.2 1.5 5.2e-16 59.2 1.5 1.5 1 0 0 1 1 1 1 Lectin C-type domain Ly49 PF08391.8 NM_001014997.1_1 - 0.00067 19.9 14.4 0.0018 18.5 0.2 2.7 2 1 1 3 3 3 2 Ly49-like protein, N-terminal region DUF2371 PF10177.7 NM_001014997.1_1 - 0.22 11.6 0.7 0.59 10.2 0.7 1.7 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) AIB PF15334.4 NM_001081099.1_1 - 8.9e-131 435.9 2.3 1e-130 435.7 2.3 1.0 1 0 0 1 1 1 1 Aurora kinase A and ninein interacting protein zf-C4 PF00105.16 NM_001163700.1_1 - 1.5e-28 98.9 14.3 1.5e-28 98.9 14.3 2.0 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001163700.1_1 - 5.7e-25 88.0 1.6 1.1e-24 87.1 1.0 1.8 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor IIGP PF05049.11 NM_001024230.2_3 - 6.5e-176 584.8 0.5 1.6e-150 501.3 0.0 2.2 2 0 0 2 2 2 2 Interferon-inducible GTPase (IIGP) Dynamin_N PF00350.21 NM_001024230.2_3 - 1.7e-06 28.1 0.1 0.011 15.7 0.1 2.6 1 1 1 2 2 2 2 Dynamin family MMR_HSR1 PF01926.21 NM_001024230.2_3 - 1.8e-06 27.9 0.0 3.8e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.4 NM_001024230.2_3 - 0.0067 16.7 0.0 0.031 14.5 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain FeoB_N PF02421.16 NM_001024230.2_3 - 0.0092 15.4 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Sigma70_r4 PF04545.14 NM_001024230.2_3 - 0.012 15.0 0.1 4.4 6.8 0.0 2.5 2 0 0 2 2 2 0 Sigma-70, region 4 DUF258 PF03193.14 NM_001024230.2_3 - 0.012 15.4 0.1 0.036 13.8 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.25 NM_001024230.2_3 - 0.016 15.6 0.0 0.039 14.3 0.0 1.6 1 0 0 1 1 1 0 ABC transporter DUF4795 PF16043.3 NM_001024230.2_3 - 0.034 13.6 1.2 1.6 8.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) AAA_29 PF13555.4 NM_001024230.2_3 - 0.034 13.7 0.1 0.064 12.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.24 NM_001024230.2_3 - 0.045 13.3 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain T2SSE PF00437.18 NM_001024230.2_3 - 0.069 12.1 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AIG1 PF04548.14 NM_001024230.2_3 - 0.083 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 AIG1 family Roc PF08477.11 NM_001024230.2_3 - 0.089 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.16 NM_001024230.2_3 - 0.09 12.0 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.4 NM_001024230.2_3 - 0.12 12.5 0.1 0.46 10.6 0.0 2.0 2 0 0 2 2 1 0 AAA domain DUF2316 PF10078.7 NM_001024230.2_3 - 0.12 12.5 0.5 4.3 7.5 0.0 2.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) UPF0122 PF04297.12 NM_001024230.2_3 - 0.13 12.4 2.2 14 5.9 0.4 2.7 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like GP3_package PF16677.3 NM_001024230.2_3 - 0.16 11.9 0.1 0.45 10.5 0.1 1.7 1 0 0 1 1 1 0 DNA-packaging protein gp3 DUF1342 PF07072.9 NM_001024230.2_3 - 0.33 10.5 2.0 1.5 8.4 0.1 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF1342) Mga PF05043.11 NM_001024230.2_3 - 1.6 9.3 5.6 7.5 7.1 0.1 3.5 4 0 0 4 4 3 0 Mga helix-turn-helix domain AAA_23 PF13476.4 NM_001024230.2_3 - 3.3 8.0 9.2 0.73 10.2 2.4 2.7 1 1 1 2 2 2 0 AAA domain p450 PF00067.20 NM_024442.1_2 - 3.9e-131 437.9 0.0 4.8e-131 437.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Lipocalin PF00061.21 NM_001135127.2_1 - 2.7e-31 108.6 0.1 3.3e-31 108.3 0.1 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family ELH PF02323.13 NM_001135127.2_1 - 0.041 13.1 0.0 0.061 12.6 0.0 1.2 1 0 0 1 1 1 0 Egg-laying hormone precursor MEF2_binding PF09047.8 NM_172549.3_1 - 4.7e-23 80.6 5.4 1.2e-22 79.3 5.4 1.8 1 0 0 1 1 1 1 MEF2 binding TPR_2 PF07719.15 NM_172549.3_1 - 1.2e-08 34.3 19.4 0.38 10.9 0.1 7.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.4 NM_172549.3_1 - 5.9e-06 26.7 2.9 11 6.7 0.0 6.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_172549.3_1 - 2.4e-05 23.8 3.0 0.0029 17.1 0.0 4.3 5 0 0 5 5 5 1 TPR repeat TPR_1 PF00515.26 NM_172549.3_1 - 2.8e-05 23.6 22.9 0.041 13.6 0.1 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.4 NM_172549.3_1 - 2.9e-05 23.8 12.5 0.42 10.8 0.2 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat FAT PF02259.21 NM_172549.3_1 - 0.0021 17.2 0.2 0.0099 15.0 0.0 2.1 2 0 0 2 2 2 1 FAT domain TPR_17 PF13431.4 NM_172549.3_1 - 0.066 13.5 13.6 8 7.0 0.0 6.6 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_7 PF13176.4 NM_172549.3_1 - 0.15 12.0 4.0 1.7 8.7 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.4 NM_172549.3_1 - 0.33 11.0 2.5 1 9.4 0.9 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 NM_172549.3_1 - 1.7 8.8 15.8 5.5 7.2 0.1 4.7 3 1 0 3 3 3 0 Tetratricopeptide repeat RasGEF PF00617.17 NM_181318.4_2 - 3e-52 177.1 0.5 5.6e-52 176.3 0.5 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 NM_181318.4_2 - 8.8e-16 57.9 0.1 2e-15 56.8 0.1 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif IFT57 PF10498.7 NM_181318.4_2 - 0.051 12.4 0.4 0.077 11.8 0.4 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 UQ_con PF00179.24 NM_009455.3_3 - 2.5e-46 156.7 0.0 5.2e-46 155.6 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme SR-25 PF10500.7 NM_009455.3_3 - 0.014 14.9 6.1 0.019 14.4 6.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Prok-E2_B PF14461.4 NM_009455.3_3 - 0.016 14.8 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.20 NM_009455.3_3 - 0.034 14.3 0.0 0.055 13.6 0.0 1.4 1 0 0 1 1 1 0 RWD domain Pkinase PF00069.23 NM_207210.2_2 - 7.5e-55 186.0 0.1 1.4e-54 185.1 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_207210.2_2 - 6e-19 68.2 0.1 1.3e-18 67.1 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_207210.2_2 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family bZIP_2 PF07716.13 NM_001287515.1_1 - 1.9e-15 56.5 15.2 1.9e-15 56.5 15.2 1.6 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.19 NM_001287515.1_1 - 7.5e-05 22.6 7.1 0.00014 21.8 7.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor Taxilin PF09728.7 NM_001287515.1_1 - 0.018 14.2 1.7 0.024 13.8 1.7 1.1 1 0 0 1 1 1 0 Myosin-like coiled-coil protein bZIP_Maf PF03131.15 NM_001287515.1_1 - 0.046 14.1 6.4 0.08 13.3 6.4 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor Lipoprotein_20 PF13942.4 NM_001287515.1_1 - 0.05 13.4 3.7 0.087 12.6 3.7 1.2 1 0 0 1 1 1 0 YfhG lipoprotein TolA_bind_tri PF16331.3 NM_001287515.1_1 - 0.064 13.2 1.7 0.11 12.4 1.7 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation Nup54 PF13874.4 NM_001287515.1_1 - 0.26 11.2 3.6 0.41 10.6 3.6 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DivIC PF04977.13 NM_001287515.1_1 - 0.31 10.7 1.5 0.58 9.8 1.5 1.3 1 0 0 1 1 1 0 Septum formation initiator IBB PF01749.18 NM_001287515.1_1 - 2.2 8.5 9.4 5 7.4 9.4 1.5 1 0 0 1 1 1 0 Importin beta binding domain dCMP_cyt_deam_1 PF00383.21 NM_001168538.1_1 - 1.4e-17 63.3 0.6 1.3e-08 34.5 0.0 2.7 2 1 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 NM_001168538.1_1 - 1.1e-11 44.5 0.7 0.00013 21.6 0.2 2.8 2 1 0 2 2 2 2 MafB19-like deaminase RRM_1 PF00076.20 NM_001287015.1_3 - 2.3e-17 62.5 0.1 6.7e-08 32.1 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase_Tyr PF07714.15 NM_001037129.1_1 - 4.6e-93 311.1 0.0 6.2e-93 310.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.14 NM_001037129.1_1 - 3.6e-50 167.8 0.0 1.5e-21 76.1 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001037129.1_1 - 3.7e-44 149.1 0.6 1.7e-17 63.7 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Pkinase PF00069.23 NM_001037129.1_1 - 4.3e-39 134.3 0.0 7.2e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.4 NM_001037129.1_1 - 3.8e-28 97.5 0.1 9.3e-10 38.6 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_001037129.1_1 - 6.4e-23 80.6 0.0 3.5e-09 36.6 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Fz PF01392.20 NM_001037129.1_1 - 1.9e-13 51.0 2.4 4.1e-13 49.9 2.4 1.6 1 0 0 1 1 1 1 Fz domain C2-set_2 PF08205.10 NM_001037129.1_1 - 1.2e-09 38.0 0.1 0.2 11.6 0.0 3.6 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain V-set PF07686.15 NM_001037129.1_1 - 3.5e-08 33.4 2.6 0.0027 17.7 0.0 4.8 4 2 1 5 5 5 2 Immunoglobulin V-set domain CD34_antigen PF06365.10 NM_001037129.1_1 - 0.00017 21.2 0.1 0.00028 20.4 0.1 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family Izumo-Ig PF16706.3 NM_001037129.1_1 - 0.088 12.7 0.1 0.6 10.1 0.0 2.2 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Sin3a_C PF16879.3 NM_001110351.1_3 - 1.1e-100 337.0 9.5 1.1e-100 337.0 9.5 2.0 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein PAH PF02671.19 NM_001110351.1_3 - 1.7e-49 165.6 5.3 7.3e-19 67.5 0.0 3.9 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.10 NM_001110351.1_3 - 5.1e-42 141.8 0.2 1.2e-41 140.6 0.2 1.7 1 0 0 1 1 1 1 Sin3 family co-repressor Aha1_N PF09229.9 NM_146036.1_2 - 5.4e-38 130.1 1.2 8e-38 129.6 1.2 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.9 NM_146036.1_2 - 4e-25 88.3 0.5 9.2e-25 87.1 0.5 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Gal-bind_lectin PF00337.20 NM_173752.4_1 - 3e-27 94.7 0.0 4e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 Galactoside-binding lectin Mito_carr PF00153.25 NM_013770.2_1 - 6.7e-53 176.5 0.8 7.1e-17 61.0 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein DCAF17 PF15802.3 NM_001165982.1_1 - 1.2e-17 63.6 0.1 1.7e-17 63.1 0.1 1.1 1 0 0 1 1 1 1 DDB1- and CUL4-associated factor 17 DCAF17 PF15802.3 NM_001165982.1_2 - 1.2e-94 317.6 0.1 1.5e-94 317.2 0.1 1.1 1 0 0 1 1 1 1 DDB1- and CUL4-associated factor 17 Costars PF14705.4 NM_175456.4_2 - 2.1e-32 111.0 0.1 3.2e-32 110.4 0.1 1.3 1 0 0 1 1 1 1 Costars Ribosomal_L6 PF00347.21 NM_011292.2_1 - 9.7e-33 112.6 1.9 1.3e-15 57.7 0.4 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 HIN PF02760.13 NM_001302651.1_1 - 1.8e-69 232.6 0.0 2.6e-69 232.0 0.0 1.2 1 0 0 1 1 1 1 HIN-200/IF120x domain PYRIN PF02758.14 NM_001302651.1_1 - 3.6e-13 49.4 2.7 6.5e-13 48.6 2.7 1.4 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain TcdB_N PF12918.5 NM_001302651.1_2 - 0.11 12.6 2.8 0.16 12.1 1.8 1.8 1 1 0 1 1 1 0 TcdB toxin N-terminal helical domain Pkinase PF00069.23 NM_001166656.1_3 - 4.5e-74 249.0 0.0 7e-74 248.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001166656.1_3 - 8.2e-38 130.0 0.0 3.4e-37 128.0 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001166656.1_3 - 8.9e-07 28.4 0.0 1.6e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 NM_001166656.1_3 - 0.00014 21.3 0.1 0.00027 20.4 0.1 1.4 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.4 NM_001166656.1_3 - 0.00028 20.4 0.4 0.15 11.6 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 NM_001166656.1_3 - 0.00048 19.4 0.4 0.00089 18.5 0.4 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MdcG PF10620.7 NM_001166656.1_3 - 0.0094 15.6 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl-dephospho-CoA transferase MdcG APH PF01636.21 NM_001166656.1_3 - 0.075 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PARP PF00644.18 NM_001205239.1_3 - 9.9e-13 48.1 0.2 1.9e-12 47.1 0.2 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain V1R PF03402.12 NM_001167538.1_1 - 4.9e-15 55.7 10.5 6.5e-15 55.3 10.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001167538.1_1 - 3.4e-14 52.5 13.4 4.2e-14 52.2 13.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001167538.1_1 - 4.1e-06 26.1 13.1 5.5e-06 25.7 13.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1700 PF08006.9 NM_001167538.1_1 - 0.089 12.2 3.2 0.14 11.6 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Glyco_transf_11 PF01531.14 NM_001271993.1_1 - 1.5e-135 451.0 0.0 2e-135 450.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 11 UDPGP PF01704.16 NM_139297.6_2 - 5.3e-198 657.6 0.1 6.2e-198 657.4 0.1 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase PRORP PF16953.3 NM_025373.1_3 - 1.7e-102 341.9 0.3 3e-102 341.1 0.3 1.4 1 0 0 1 1 1 1 Protein-only RNase P PPR_2 PF13041.4 NM_025373.1_3 - 0.0024 17.9 0.1 0.56 10.3 0.1 3.3 1 1 2 3 3 3 2 PPR repeat family PPR PF01535.18 NM_025373.1_3 - 0.12 12.5 0.0 2.4 8.4 0.0 2.8 2 0 0 2 2 2 0 PPR repeat KH_1 PF00013.27 NM_198615.2_1 - 6.5e-25 86.6 2.0 8.7e-13 47.8 0.1 2.4 2 0 0 2 2 2 2 KH domain zf-C3HC4_3 PF13920.4 NM_198615.2_1 - 1e-10 41.2 8.7 2.2e-10 40.1 8.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_198615.2_1 - 2.1e-05 24.5 9.5 4.4e-05 23.5 9.5 1.6 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.4 NM_198615.2_1 - 0.00026 20.6 10.0 0.0005 19.7 10.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.23 NM_198615.2_1 - 0.0017 18.1 9.1 0.0033 17.1 9.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) KH_2 PF07650.15 NM_198615.2_1 - 0.016 14.9 0.2 1.7 8.4 0.0 2.2 2 0 0 2 2 2 0 KH domain KH_4 PF13083.4 NM_198615.2_1 - 0.04 13.7 0.0 4.5 7.1 0.0 2.2 2 0 0 2 2 2 0 KH domain zf-RING_4 PF14570.4 NM_198615.2_1 - 0.046 13.3 5.2 0.092 12.4 5.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.4 NM_198615.2_1 - 9.8 6.3 10.7 21 5.2 10.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING 7tm_1 PF00001.19 NM_019925.4_3 - 4.7e-31 107.9 23.5 7.8e-31 107.2 23.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2975 PF11188.6 NM_019925.4_3 - 2.8 7.7 8.3 0.53 10.0 3.9 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2975) MRP-S23 PF10484.7 NM_024174.6_1 - 3.8e-49 166.1 0.0 5e-49 165.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S23 MRP-S25 PF13741.4 NM_024174.6_1 - 2.1e-07 30.6 1.0 0.00012 21.6 0.0 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 Mg_trans_NIPA PF05653.12 NM_028995.3_3 - 2.7e-70 236.7 21.0 3.5e-70 236.3 21.0 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA DUF4131 PF13567.4 NM_028995.3_3 - 9.7 5.6 20.9 2.1 7.8 5.4 4.0 2 1 2 4 4 4 0 Domain of unknown function (DUF4131) Plant_zn_clust PF10533.7 NM_001290737.1_1 - 1.1 9.2 6.8 3.2 7.6 6.8 1.9 1 0 0 1 1 1 0 Plant zinc cluster domain Thg1C PF14413.4 NM_001290737.1_3 - 1.7e-46 157.2 0.2 2.6e-46 156.6 0.2 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain Thg1 PF04446.10 NM_001290737.1_3 - 6.9e-35 119.7 0.3 1.1e-34 119.0 0.3 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase TAS2R PF05296.11 NM_001166749.1_1 - 2.2e-14 53.1 19.7 2.8e-14 52.8 19.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 NM_001166749.1_1 - 4.8e-13 49.2 14.7 6.6e-13 48.7 14.7 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 NM_001166749.1_1 - 1.1e-06 28.0 16.9 1.4e-06 27.6 16.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PRP8_domainIV PF12134.6 NM_001166749.1_1 - 0.006 16.1 1.2 0.11 12.0 0.1 2.7 2 1 1 3 3 3 1 PRP8 domain IV core DUF1700 PF08006.9 NM_001166749.1_1 - 0.13 11.6 8.6 0.097 12.1 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) PhoLip_ATPase_C PF16212.3 NM_176999.3_1 - 1.1e-80 270.8 22.5 2.6e-80 269.6 22.5 1.7 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 NM_176999.3_1 - 1.8e-23 81.9 0.9 5.7e-23 80.3 0.9 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.24 NM_176999.3_1 - 7.1e-09 36.1 0.0 0.00022 21.4 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.4 NM_176999.3_1 - 4.2e-08 33.0 0.0 2e-07 30.9 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.18 NM_176999.3_1 - 2.3e-05 23.7 0.0 4.4e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.10 NM_176999.3_1 - 0.008 15.8 0.0 0.022 14.4 0.0 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Pkinase_Tyr PF07714.15 NM_001162366.1_2 - 3.1e-94 315.0 0.0 5e-94 314.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.11 NM_001162366.1_2 - 1.6e-52 176.8 3.2 3e-52 175.9 3.2 1.5 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.23 NM_001162366.1_2 - 9.4e-44 149.6 0.0 1.6e-43 148.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 NM_001162366.1_2 - 5.1e-12 46.1 1.4 1.6e-11 44.5 1.4 1.8 1 0 0 1 1 1 1 FERM central domain Kinase-like PF14531.4 NM_001162366.1_2 - 0.025 13.8 0.0 0.061 12.5 0.0 1.6 2 0 0 2 2 2 0 Kinase-like AMP-binding PF00501.26 NM_001033598.1_3 - 2.1e-109 365.8 0.0 3.1e-109 365.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 NM_001033598.1_3 - 8.3e-05 23.4 0.0 0.00021 22.1 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Pkinase_Tyr PF07714.15 NM_001281965.1_1 - 1.7e-91 305.9 0.0 2.3e-91 305.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001281965.1_1 - 3.8e-46 157.4 0.0 5.7e-46 156.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 NM_001281965.1_1 - 2.8e-21 75.2 0.0 5.2e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 NM_001281965.1_1 - 1.9e-12 46.4 0.1 4e-12 45.4 0.1 1.6 1 0 0 1 1 1 1 SH3 domain BTK PF00779.17 NM_001281965.1_1 - 2.2e-12 46.4 1.8 2.2e-12 46.4 1.8 2.4 2 0 0 2 2 2 1 BTK motif PH PF00169.27 NM_001281965.1_1 - 1.1e-11 45.1 0.2 3e-11 43.6 0.2 1.8 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.4 NM_001281965.1_1 - 3.4e-09 36.3 0.3 6.6e-09 35.4 0.3 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001281965.1_1 - 0.0005 19.6 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_8 PF15409.4 NM_001281965.1_1 - 0.0023 18.0 0.1 0.0056 16.8 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_3 PF08239.9 NM_001281965.1_1 - 0.0051 16.9 0.1 0.011 15.8 0.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.11 NM_001281965.1_1 - 0.088 12.5 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain Homeobox PF00046.27 NM_010835.2_1 - 9.2e-21 73.3 4.6 1.5e-20 72.6 4.6 1.4 1 0 0 1 1 1 1 Homeobox domain DUF2457 PF10446.7 NM_010835.2_1 - 2.4 7.1 7.2 3.7 6.5 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CP2 PF04516.13 NM_026496.4_1 - 2.5e-84 282.0 3.8 4.5e-84 281.2 3.8 1.4 1 0 0 1 1 1 1 CP2 transcription factor GTSE1_N PF15259.4 NM_001168672.1_3 - 4.1e-58 195.6 1.4 6.7e-58 194.9 0.1 2.0 2 0 0 2 2 2 1 G-2 and S-phase expressed 1 ABC_membrane PF00664.21 NM_145140.2_2 - 2.7e-55 187.8 4.4 1.7e-31 109.8 0.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 NM_145140.2_2 - 5e-53 179.2 0.0 1.6e-31 109.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 NM_145140.2_2 - 3e-09 36.5 5.3 0.015 14.6 0.1 4.1 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 NM_145140.2_2 - 8.9e-06 25.2 0.5 0.051 13.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.4 NM_145140.2_2 - 1.5e-05 24.8 0.6 2.2 7.9 0.1 3.5 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.21 NM_145140.2_2 - 1.8e-05 24.7 0.3 0.097 12.6 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.4 NM_145140.2_2 - 0.00061 20.1 4.8 0.78 10.0 0.1 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.4 NM_145140.2_2 - 0.0019 18.6 0.4 1.1 9.6 0.1 2.2 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.15 NM_145140.2_2 - 0.0023 17.9 0.9 0.034 14.0 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_30 PF13604.4 NM_145140.2_2 - 0.009 15.6 0.3 0.52 9.9 0.1 2.9 2 1 0 2 2 2 1 AAA domain DUF258 PF03193.14 NM_145140.2_2 - 0.016 15.0 0.2 0.88 9.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_22 PF13401.4 NM_145140.2_2 - 0.045 13.9 1.5 6.8 6.8 0.0 2.9 2 1 0 2 2 2 0 AAA domain KAP_NTPase PF07693.12 NM_145140.2_2 - 0.071 12.2 0.0 0.53 9.3 0.1 2.0 2 0 0 2 2 2 0 KAP family P-loop domain Dynamin_N PF00350.21 NM_145140.2_2 - 2.3 8.1 3.8 2.7 7.9 0.2 2.3 2 0 0 2 2 2 0 Dynamin family Cadherin PF00028.15 NM_033583.3_1 - 5.4e-80 263.8 0.0 9.1e-18 64.4 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_033583.3_1 - 3e-29 100.5 0.0 2.8e-27 94.2 0.0 3.7 4 0 0 4 4 4 1 Cadherin-like Cadherin_tail PF15974.3 NM_033583.3_1 - 1.4e-25 90.0 3.9 1.6e-25 89.8 2.8 1.7 2 0 0 2 2 2 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 NM_033583.3_1 - 2.3e-15 57.0 0.0 6.1e-15 55.7 0.0 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal LRR_8 PF13855.4 NM_212452.1_1 - 2.1e-46 155.4 32.5 9.5e-18 63.6 1.5 6.2 1 1 5 6 6 6 5 Leucine rich repeat 7tm_1 PF00001.19 NM_212452.1_1 - 1.9e-23 83.0 16.9 3.2e-23 82.2 16.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_4 PF12799.5 NM_212452.1_1 - 1.2e-18 66.7 27.8 1.6e-06 28.2 0.5 6.9 1 1 6 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_212452.1_1 - 2.8e-17 62.7 6.4 7.5e-10 38.7 4.1 2.8 2 1 0 3 3 3 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_212452.1_1 - 9.3e-10 38.1 13.4 0.0001 21.7 0.7 3.8 1 1 2 3 3 3 3 Leucine-rich repeat Ldl_recept_a PF00057.16 NM_212452.1_1 - 1.7e-06 28.0 3.7 1.7e-06 28.0 3.7 2.4 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A LRR_1 PF00560.31 NM_212452.1_1 - 0.00063 19.7 21.9 13 6.6 3.5 8.8 6 2 0 6 6 6 1 Leucine Rich Repeat LRRNT PF01462.16 NM_212452.1_1 - 0.0019 17.7 1.0 0.0045 16.5 1.0 1.7 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 NM_212452.1_1 - 0.007 16.2 8.6 5.6 7.1 0.1 5.5 5 0 0 5 5 5 1 Leucine Rich repeat Rep_fac-A_3 PF08661.9 NM_026632.4_2 - 3.9e-32 110.6 0.0 5.1e-32 110.2 0.0 1.1 1 0 0 1 1 1 1 Replication factor A protein 3 MFS_1 PF07690.14 NM_172499.2_3 - 1.5e-40 139.1 27.3 2e-40 138.7 27.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_172499.2_3 - 1.5e-05 24.0 12.0 1.5e-05 24.0 12.0 2.3 1 1 2 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.12 NM_172499.2_3 - 4.2e-05 22.9 6.9 4.2e-05 22.9 6.9 3.1 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB C2 PF00168.28 NM_001313977.1_2 - 1.9e-13 50.5 0.0 3.6e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 C2 domain Pkinase PF00069.23 NM_001313977.1_3 - 6.1e-64 215.8 0.0 8.5e-64 215.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001313977.1_3 - 2.3e-35 122.0 0.0 3.4e-35 121.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 NM_001313977.1_3 - 7.5e-29 99.3 37.2 1.1e-15 57.1 6.5 3.0 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 NM_001313977.1_3 - 2.6e-10 40.7 0.2 5.3e-10 39.7 0.2 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_001313977.1_3 - 1.8e-05 24.0 0.0 0.00013 21.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like C1_2 PF03107.14 NM_001313977.1_3 - 0.0031 17.7 17.0 0.084 13.1 2.5 2.9 2 0 0 2 2 2 2 C1 domain FTA2 PF13095.4 NM_001313977.1_3 - 0.004 16.7 0.1 0.4 10.1 0.0 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.21 NM_001313977.1_3 - 0.09 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Zf_RING PF16744.3 NM_001313977.1_3 - 1 9.4 14.3 6.3 6.9 0.9 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger Defensin_beta_2 PF13841.4 NM_001001444.2_2 - 3.5e-06 27.3 10.3 3.5e-06 27.3 10.3 2.2 3 0 0 3 3 3 1 Beta defensin TAS2R PF05296.11 NM_001167166.1_1 - 1.4e-15 57.1 19.2 1.8e-15 56.7 19.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 NM_001167166.1_1 - 4.4e-14 52.6 13.8 6e-14 52.2 13.8 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 NM_001167166.1_1 - 6.5e-07 28.7 16.7 8.4e-07 28.3 16.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PRP8_domainIV PF12134.6 NM_001167166.1_1 - 0.012 15.2 0.8 0.11 12.0 0.1 2.5 2 1 1 3 3 3 0 PRP8 domain IV core DUF1700 PF08006.9 NM_001167166.1_1 - 0.11 11.9 8.5 0.082 12.3 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Anoctamin PF04547.10 NM_001167166.1_1 - 0.78 8.3 10.0 0.7 8.5 9.2 1.5 1 1 0 1 1 1 0 Calcium-activated chloride channel Tmemb_cc2 PF10267.7 NM_001311108.1_3 - 1.6e-174 580.5 3.5 1.9e-174 580.3 3.5 1.0 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Exonuc_VII_L PF02601.13 NM_001311108.1_3 - 0.022 14.2 17.0 0.3 10.5 0.8 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit TraG_N PF07916.9 NM_001311108.1_3 - 0.03 13.0 0.3 0.051 12.3 0.3 1.3 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Prominin PF05478.9 NM_001311108.1_3 - 0.041 11.7 15.3 0.0082 14.0 5.0 2.3 2 0 0 2 2 2 0 Prominin Baculo_PEP_C PF04513.10 NM_001311108.1_3 - 0.92 9.4 11.4 0.073 13.0 0.7 3.2 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1479 PF07350.10 NM_001311108.1_3 - 1 7.9 5.1 0.83 8.2 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) Lipoprotein_20 PF13942.4 NM_001311108.1_3 - 1.7 8.4 17.3 3.6 7.4 5.5 2.4 2 0 0 2 2 2 0 YfhG lipoprotein Atg14 PF10186.7 NM_001311108.1_3 - 1.8 7.4 20.6 0.63 8.9 3.4 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0565 PF10561.7 NM_001311108.1_3 - 4.2 6.4 6.0 0.73 8.8 1.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 Lectin_C PF00059.19 NM_010775.2_1 - 1.4e-17 64.2 0.0 2.1e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 NM_010775.2_1 - 9.1e-08 31.6 24.2 1.5e-07 30.9 24.2 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Peptidase_M13_N PF05649.11 NM_001277925.1_1 - 1.6e-110 370.2 0.0 2.1e-110 369.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.19 NM_001277925.1_1 - 1.2e-69 233.9 0.1 2.2e-69 233.0 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M13 Ig_2 PF13895.4 NM_001290316.1_1 - 1.2e-23 83.1 0.0 2.7e-15 56.3 0.0 5.0 5 0 0 5 5 5 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001290316.1_1 - 6.4e-22 77.8 0.0 1.1e-06 29.0 0.0 4.9 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 NM_001290316.1_1 - 2.4e-15 56.2 0.0 0.00087 19.2 0.0 5.0 4 1 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.23 NM_001290316.1_1 - 7.5e-09 35.5 0.0 0.0019 18.2 0.0 4.8 5 1 0 5 5 5 2 Immunoglobulin domain V-set PF07686.15 NM_001290316.1_1 - 1.2e-05 25.3 0.0 3.3 7.8 0.0 4.5 4 2 1 5 5 5 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001290316.1_1 - 0.00049 20.0 3.7 4.1 7.4 0.0 4.7 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain DUF4690 PF15756.3 NM_001290316.1_1 - 0.008 16.6 0.1 0.019 15.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4690) CYYR1 PF10873.6 NM_001290316.1_1 - 0.029 14.7 0.1 0.067 13.5 0.1 1.6 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Herpes_gE PF02480.14 NM_001290316.1_1 - 0.1 11.2 0.0 0.3 9.6 0.0 1.6 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E DUF4514 PF14986.4 NM_001290316.1_1 - 1.4 8.8 3.0 2.8 7.8 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) CLCA PF08434.9 NM_207208.3_2 - 0 1203.0 1.3 0 1202.7 1.3 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel VWA PF00092.26 NM_207208.3_2 - 1.4e-13 51.3 1.1 5.2e-13 49.5 0.1 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.4 NM_207208.3_2 - 3.7e-13 49.9 0.0 1.6e-12 47.9 0.1 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 NM_207208.3_2 - 9e-06 25.1 0.0 1.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein A2M_N PF01835.17 NM_207208.3_2 - 0.13 12.6 0.1 1.2 9.6 0.0 2.3 2 0 0 2 2 2 0 MG2 domain RRM_1 PF00076.20 NM_029872.1_1 - 1.9e-30 104.3 0.2 5.3e-14 51.6 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_029872.1_1 - 3e-07 30.3 0.3 0.003 17.5 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif Ski_Sno PF02437.15 NM_172446.3_2 - 1.8e-38 130.5 0.1 3.3e-38 129.7 0.1 1.4 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.8 NM_172446.3_2 - 7e-31 106.2 1.1 7e-31 106.2 1.1 1.7 2 0 0 2 2 2 1 c-SKI Smad4 binding domain Trypsin PF00089.24 NM_001193631.1_3 - 1.3e-31 110.0 0.2 1.6e-31 109.7 0.2 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_001193631.1_3 - 0.08 13.2 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) HIN PF02760.13 NM_172648.3_3 - 2e-73 245.5 1.2 3.4e-73 244.7 1.2 1.4 1 0 0 1 1 1 1 HIN-200/IF120x domain PYRIN PF02758.14 NM_172648.3_3 - 2.9e-08 33.6 0.4 2.9e-08 33.6 0.4 2.0 2 0 0 2 2 2 1 PAAD/DAPIN/Pyrin domain ATG16 PF08614.9 NM_172648.3_3 - 1.9 8.5 11.6 0.046 13.8 4.4 1.9 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) TPR_12 PF13424.4 NM_025905.3_1 - 5.1e-14 52.2 18.9 7.3e-06 26.1 0.2 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.15 NM_025905.3_1 - 0.0002 21.1 24.3 2.6 8.2 0.1 7.4 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_025905.3_1 - 0.00024 21.0 19.3 0.095 12.8 0.1 6.7 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_025905.3_1 - 0.001 18.6 11.7 0.55 10.0 0.7 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.4 NM_025905.3_1 - 0.0019 17.9 10.2 9.5 6.1 0.0 6.6 8 0 0 8 8 8 2 Tetratricopeptide repeat SHNi-TPR PF10516.7 NM_025905.3_1 - 0.046 13.1 0.4 2 7.8 0.0 3.2 3 0 0 3 3 3 0 SHNi-TPR TPR_14 PF13428.4 NM_025905.3_1 - 0.35 11.7 14.4 18 6.3 0.0 6.6 6 2 1 7 7 7 0 Tetratricopeptide repeat HCO3_cotransp PF00955.19 NM_001253892.1_3 - 6.9e-214 711.3 4.6 9e-214 710.9 4.6 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 NM_001253892.1_3 - 1.5e-105 352.7 0.1 2.3e-105 352.1 0.1 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 NM_001253892.1_3 - 0.00022 21.0 0.0 0.0004 20.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Cytochrom_B_C PF00032.15 NM_001253892.1_3 - 0.87 9.8 6.0 3 8.1 0.3 3.4 3 0 0 3 3 3 0 Cytochrome b(C-terminal)/b6/petD PCM1_C PF15717.3 NM_023662.3_3 - 2e-279 928.5 41.4 2e-279 928.5 41.4 5.6 4 1 1 6 6 6 1 Pericentriolar material 1 C terminus Cys_rich_CPCC PF14206.4 NM_023662.3_3 - 0.85 9.3 5.5 12 5.7 0.1 3.5 4 0 0 4 4 4 0 Cysteine-rich CPCC Tmemb_cc2 PF10267.7 NM_178874.3_3 - 3.1e-174 579.6 3.5 3.1e-174 579.6 3.5 1.6 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein TraG_N PF07916.9 NM_178874.3_3 - 0.04 12.6 0.3 0.07 11.8 0.3 1.3 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Prominin PF05478.9 NM_178874.3_3 - 0.073 10.9 15.3 0.011 13.6 5.0 2.2 2 0 0 2 2 2 0 Prominin Baculo_PEP_C PF04513.10 NM_178874.3_3 - 1.1 9.1 10.7 0.093 12.6 0.6 3.1 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1479 PF07350.10 NM_178874.3_3 - 1.5 7.4 5.1 1.1 7.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) Lipoprotein_20 PF13942.4 NM_178874.3_3 - 1.8 8.4 16.8 3.3 7.5 5.0 2.5 2 0 0 2 2 2 0 YfhG lipoprotein Exonuc_VII_L PF02601.13 NM_178874.3_3 - 2.7 7.3 25.1 0.43 10.0 0.9 2.9 3 0 0 3 3 3 0 Exonuclease VII, large subunit SCAN PF02023.15 NM_001017955.2_1 - 4.5e-34 116.0 0.4 4.5e-34 116.0 0.4 2.4 2 0 0 2 2 2 1 SCAN domain zf-C2H2_6 PF13912.4 NM_001017955.2_1 - 0.012 15.4 2.1 0.022 14.6 0.3 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001017955.2_1 - 0.028 14.8 0.3 0.11 12.8 0.3 2.2 1 0 0 1 1 1 0 Zinc finger, C2H2 type Calsequestrin PF01216.15 NM_009813.2_2 - 5.9e-235 779.2 24.4 7.7e-235 778.8 24.4 1.1 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.4 NM_009813.2_2 - 1.4e-22 80.4 8.5 1.3e-17 64.2 2.2 2.9 2 1 1 3 3 3 2 Thioredoxin-like domain WGG PF10273.7 NM_009813.2_2 - 0.52 10.9 4.4 0.73 10.4 1.4 2.3 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 SDA1 PF05285.10 NM_009813.2_2 - 3.8 6.7 7.7 5.6 6.2 7.7 1.2 1 0 0 1 1 1 0 SDA1 LAX PF15681.3 NM_172842.3_1 - 5e-168 558.4 0.2 6.2e-168 558.1 0.2 1.1 1 0 0 1 1 1 1 Lymphocyte activation family X zf-H2C2_2 PF13465.4 NM_001163246.2_1 - 2.8e-206 659.6 291.5 2e-08 34.1 2.3 33.4 34 0 0 34 34 33 32 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001163246.2_1 - 7.6e-109 350.4 262.0 4.4e-05 23.6 2.1 33.1 33 0 0 33 33 33 30 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001163246.2_1 - 9.5e-75 240.6 263.6 0.0023 18.5 2.8 33.4 33 0 0 33 33 33 30 C2H2-type zinc finger BolA PF01722.16 NM_001163246.2_1 - 4.3e-26 90.9 42.7 0.2 11.9 0.0 18.5 9 7 9 19 19 19 9 BolA-like protein zf-C2H2_6 PF13912.4 NM_001163246.2_1 - 1.9e-22 78.6 212.6 0.0008 19.2 0.6 31.4 30 1 0 30 30 30 18 C2H2-type zinc finger KRAB PF01352.25 NM_001163246.2_1 - 2.9e-21 74.7 0.1 5.3e-21 73.9 0.1 1.4 1 0 0 1 1 1 1 KRAB box C1_1 PF00130.20 NM_001163246.2_1 - 1.7e-13 50.1 144.1 0.027 14.2 0.9 18.5 8 3 16 24 24 24 18 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.3 NM_001163246.2_1 - 5.8e-13 48.6 134.4 1.4 8.9 0.2 28.6 4 4 26 31 31 31 8 KIAA1045 RING finger Zn-ribbon_8 PF09723.8 NM_001163246.2_1 - 1.1e-12 47.7 159.4 0.23 11.5 3.0 21.6 8 5 17 27 27 27 15 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_001163246.2_1 - 3.9e-12 45.6 135.4 0.017 14.7 0.9 24.9 28 0 0 28 28 28 10 zinc-finger C2H2-type Desulfoferrod_N PF06397.10 NM_001163246.2_1 - 1.7e-10 40.2 172.4 0.21 11.1 0.4 29.7 31 0 0 31 31 31 18 Desulfoferrodoxin, N-terminal domain FYVE PF01363.19 NM_001163246.2_1 - 2.2e-05 24.4 134.1 0.6 10.2 3.7 17.3 2 1 9 11 11 9 4 FYVE zinc finger zf-C2HC_2 PF13913.4 NM_001163246.2_1 - 6.4e-05 22.6 173.9 0.015 15.1 0.8 28.9 32 0 0 32 32 32 8 zinc-finger of a C2HC-type XPA_N PF01286.16 NM_001163246.2_1 - 0.0051 16.7 138.0 0.43 10.5 0.2 29.4 31 0 0 31 31 31 4 XPA protein N-terminal C1_4 PF07975.10 NM_001163246.2_1 - 0.095 12.8 142.6 1.1 9.4 0.1 20.0 7 4 8 20 20 20 0 TFIIH C1-like domain zf-H2C2_2 PF13465.4 NM_001163246.2_3 - 6.7e-10 38.8 25.2 0.0046 17.2 3.3 5.5 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001163246.2_3 - 1 10.2 21.1 1.6 9.6 3.0 4.9 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001163246.2_3 - 2.5 8.6 19.8 1.1 9.7 0.2 5.0 4 0 0 4 4 4 0 Zinc finger, C2H2 type C2 PF00168.28 NM_001276681.1_2 - 6.8e-50 167.5 0.0 1.5e-23 82.9 0.0 2.4 2 0 0 2 2 2 2 C2 domain TRAM_LAG1_CLN8 PF03798.14 NM_029978.1_3 - 1.3e-44 152.1 12.8 1.9e-44 151.7 12.8 1.1 1 0 0 1 1 1 1 TLC domain DUF3487 PF11990.6 NM_029978.1_3 - 0.044 13.5 0.2 0.12 12.1 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) Pkinase PF00069.23 NM_001316368.1_1 - 1.2e-48 165.6 0.0 1.7e-48 165.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001316368.1_1 - 8e-32 110.4 0.0 1.2e-31 109.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001316368.1_1 - 4.9e-06 25.9 0.0 7.4e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.9 NM_001316368.1_1 - 0.0018 17.2 0.1 0.0028 16.6 0.1 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 fn3 PF00041.19 NM_001277106.1_2 - 0.0019 18.4 0.0 0.0032 17.7 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain PRP1_N PF06424.10 NM_001277106.1_2 - 0.16 12.3 0.2 0.31 11.3 0.2 1.4 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Cadherin PF00028.15 NM_001142743.1_2 - 1.9e-122 399.9 16.5 8.8e-17 61.2 0.0 10.8 11 0 0 11 11 11 10 Cadherin domain Cadherin_3 PF16184.3 NM_001142743.1_2 - 1.9e-07 30.9 3.9 0.86 9.5 0.0 6.9 8 0 0 8 8 8 2 Cadherin-like Cadherin_2 PF08266.10 NM_001142743.1_2 - 5.6e-05 22.7 0.0 7.5 6.3 0.0 5.0 6 0 0 6 6 6 2 Cadherin-like DUF4958 PF16319.3 NM_001142743.1_2 - 0.00024 19.2 0.2 0.045 11.7 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4958) PRIMA1 PF16101.3 NM_001142743.1_2 - 0.0064 16.4 4.5 0.0064 16.4 4.5 2.0 2 0 0 2 2 2 1 Proline-rich membrane anchor 1 Cadherin_pro PF08758.9 NM_001142743.1_2 - 0.043 13.8 0.0 20 5.3 0.0 4.2 4 0 0 4 4 4 0 Cadherin prodomain like CAP_N PF01213.17 NM_001142743.1_2 - 8 5.7 12.5 14 4.9 12.5 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal F-box-like_2 PF13013.4 NM_145363.2_1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 F-box-like domain Tetraspannin PF00335.18 NM_145363.2_2 - 6.5e-34 117.5 12.0 1.2e-33 116.5 12.0 1.5 1 0 0 1 1 1 1 Tetraspanin family Folate_rec PF03024.12 NM_001252552.1_2 - 3.3e-64 215.8 27.3 4.2e-64 215.4 27.3 1.1 1 0 0 1 1 1 1 Folate receptor family Atrophin-1 PF03154.13 NM_001177781.1_1 - 1.1 7.4 21.2 1.4 7.0 21.2 1.0 1 0 0 1 1 1 0 Atrophin-1 family 7tm_1 PF00001.19 NM_001177781.1_3 - 1.9e-37 128.8 18.5 1.9e-37 128.8 18.5 1.7 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Nop16 PF09420.8 NM_178605.4_3 - 6e-22 78.6 6.1 7e-15 55.5 1.3 2.1 1 1 1 2 2 2 2 Ribosome biogenesis protein Nop16 Baculo_p33 PF05214.10 NM_178605.4_3 - 0.13 11.8 0.1 0.23 11.0 0.1 1.3 1 0 0 1 1 1 0 Baculovirus P33 ABC_tran PF00005.25 NM_175210.3_2 - 7.1e-56 188.4 0.1 2.9e-27 95.7 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC2_membrane_3 PF12698.5 NM_175210.3_2 - 4e-53 180.6 43.9 1.5e-32 113.0 11.9 2.8 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.4 NM_175210.3_2 - 1e-23 84.5 8.0 1.8e-10 41.0 0.0 4.5 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.4 NM_175210.3_2 - 1.1e-06 28.4 3.6 0.37 10.2 0.0 4.0 4 0 0 4 4 4 3 AAA ATPase domain AAA_23 PF13476.4 NM_175210.3_2 - 6.9e-06 26.6 5.0 0.0024 18.3 0.1 3.0 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.4 NM_175210.3_2 - 0.0098 15.5 3.6 0.22 11.2 0.3 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.4 NM_175210.3_2 - 0.014 15.0 0.0 1.6 8.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.17 NM_175210.3_2 - 0.014 14.7 2.6 4.3 6.6 0.1 3.8 4 0 0 4 4 4 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 NM_175210.3_2 - 0.028 14.7 0.0 5.6 7.2 0.0 2.9 2 0 0 2 2 2 0 AAA ATPase domain p47_phox_C PF08944.9 NM_175210.3_2 - 0.084 12.2 1.9 1.8 7.9 0.2 2.5 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain DUF4162 PF13732.4 NM_175210.3_2 - 0.087 13.4 0.0 0.29 11.8 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) DUF258 PF03193.14 NM_175210.3_2 - 0.089 12.6 1.5 2.6 7.8 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SbcCD_C PF13558.4 NM_175210.3_2 - 0.095 12.8 0.0 22 5.2 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit MukB PF04310.10 NM_175210.3_2 - 0.11 12.2 1.2 7 6.3 0.2 2.5 2 0 0 2 2 2 0 MukB N-terminal SRP54 PF00448.20 NM_175210.3_2 - 0.12 11.8 3.5 1.4 8.4 0.6 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_22 PF13401.4 NM_175210.3_2 - 0.48 10.6 1.9 6.4 6.9 0.1 3.4 2 1 0 2 2 2 0 AAA domain AAA PF00004.27 NM_175210.3_2 - 7 6.9 6.3 52 4.1 0.4 3.8 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) DUF4471 PF14740.4 NM_001033548.2_1 - 3.1e-101 338.4 0.0 2.2e-100 335.6 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4471) DUF4470 PF14737.4 NM_001033548.2_1 - 2.1e-24 85.4 0.0 3.3e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) Reprolysin_5 PF13688.4 NM_009615.6_3 - 6.1e-35 121.0 0.0 1.1e-34 120.2 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.4 NM_009615.6_3 - 2e-31 109.3 0.0 3.2e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM17_MPD PF16698.3 NM_009615.6_3 - 9.3e-20 70.6 15.7 9.3e-20 70.6 15.7 3.6 2 1 1 3 3 3 1 Membrane-proximal domain, switch, for ADAM17 Disintegrin PF00200.21 NM_009615.6_3 - 5.8e-15 55.7 23.9 5.8e-15 55.7 23.9 3.4 3 0 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.4 NM_009615.6_3 - 2.2e-12 47.4 0.0 4.5e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.17 NM_009615.6_3 - 3.5e-11 43.3 0.4 2.2e-06 27.6 0.2 3.0 2 1 0 2 2 2 2 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 NM_009615.6_3 - 1.9e-07 31.3 0.0 3.8e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_4 PF13583.4 NM_009615.6_3 - 1.2e-05 24.9 0.1 2.1e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like TFIIB PF00382.17 NM_145546.1_2 - 4.5e-50 167.5 3.5 2.3e-24 85.1 0.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.10 NM_145546.1_2 - 3.8e-14 51.8 0.2 6.2e-14 51.1 0.2 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.21 NM_145546.1_2 - 1.2e-07 31.4 0.1 1.1e-05 25.1 0.0 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 NM_145546.1_2 - 0.0046 16.9 0.0 0.24 11.4 0.0 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain RB_B PF01857.18 NM_145546.1_2 - 0.0067 16.3 0.1 0.015 15.2 0.1 1.5 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Sigma70_r4 PF04545.14 NM_145546.1_2 - 0.025 14.0 0.0 0.15 11.5 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 A2L_zn_ribbon PF08792.8 NM_145546.1_2 - 0.15 11.7 0.9 1.5 8.5 0.0 2.5 2 0 0 2 2 2 0 A2L zinc ribbon domain Trefoil PF00088.16 NM_007901.5_2 - 0.012 15.3 0.7 0.042 13.6 0.7 1.8 1 0 0 1 1 1 0 Trefoil (P-type) domain 7tm_1 PF00001.19 NM_007901.5_3 - 1.2e-40 139.4 18.7 1.7e-40 138.8 18.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_007901.5_3 - 2.1e-06 27.2 20.5 2.8e-06 26.8 20.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_007901.5_3 - 0.013 15.2 19.1 0.026 14.1 19.1 1.4 1 1 0 1 1 1 0 Olfactory receptor JTB PF05439.10 NM_007901.5_3 - 0.1 12.5 1.1 0.22 11.4 1.1 1.5 1 0 0 1 1 1 0 Jumping translocation breakpoint protein (JTB) Homeobox PF00046.27 NM_001289828.1_3 - 3.8e-18 64.9 5.1 6.6e-18 64.2 5.1 1.4 1 0 0 1 1 1 1 Homeobox domain Galactosyl_T PF01762.19 NM_146184.4_2 - 1.2e-29 103.4 0.0 1.5e-29 103.1 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase ATG101 PF07855.10 NM_026566.2_3 - 9.6e-41 139.2 0.1 1.3e-40 138.8 0.1 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 Scramblase PF03803.13 NM_001195084.1_3 - 3.3e-90 301.1 0.0 4.4e-90 300.7 0.0 1.1 1 0 0 1 1 1 1 Scramblase DUF4796 PF16044.3 NM_001195084.1_3 - 0.099 12.1 3.4 0.8 9.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4796) C1q PF00386.19 NM_172633.4_3 - 2e-26 92.5 0.3 3.7e-26 91.7 0.3 1.4 1 0 0 1 1 1 1 C1q domain GATA PF00320.25 NM_001103168.1_3 - 8.6e-15 53.9 12.1 1.7e-14 53.0 4.2 3.5 2 1 1 3 3 3 1 GATA zinc finger DZR PF12773.5 NM_001103168.1_3 - 0.17 11.8 11.6 11 6.0 4.5 2.9 1 1 1 2 2 2 0 Double zinc ribbon ArfGap PF01412.16 NM_001103168.1_3 - 0.45 10.4 4.0 0.37 10.7 2.7 1.4 1 1 0 1 1 1 0 Putative GTPase activating protein for Arf NOB1_Zn_bind PF08772.9 NM_001103168.1_3 - 5 7.2 8.3 0.18 11.8 1.1 2.1 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Ribonucleas_3_3 PF14622.4 NM_026799.3_1 - 7.8e-44 148.8 0.5 1.7e-23 83.1 0.0 3.1 3 0 0 3 3 3 2 Ribonuclease-III-like Ribonuclease_3 PF00636.24 NM_026799.3_1 - 9.3e-43 145.0 0.4 9.3e-21 74.3 0.1 3.0 2 0 0 2 2 2 2 Ribonuclease III domain dsrm PF00035.24 NM_026799.3_1 - 8.9e-15 55.0 0.0 2.4e-14 53.6 0.0 1.8 1 0 0 1 1 1 1 Double-stranded RNA binding motif MIP-T3 PF10243.7 NM_026799.3_1 - 1.7 7.1 25.8 3.8 6.0 25.8 1.5 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Mito_carr PF00153.25 NM_138756.4_1 - 6.8e-67 221.3 1.3 5.7e-24 83.7 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein RhoGEF PF00621.18 NM_013710.4_3 - 7.2e-44 150.1 0.4 1.3e-43 149.3 0.4 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 NM_013710.4_3 - 6.7e-19 68.2 0.0 1.7e-08 34.8 0.0 2.8 3 0 0 3 3 3 2 PH domain FYVE PF01363.19 NM_013710.4_3 - 1.2e-18 66.8 9.9 3.3e-18 65.5 9.9 1.7 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.14 NM_013710.4_3 - 1.7e-05 24.8 5.1 4.7e-05 23.4 5.1 1.7 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.3 NM_013710.4_3 - 0.00024 20.9 0.0 0.31 10.8 0.0 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain Baculo_LEF5_C PF11792.6 NM_013710.4_3 - 0.002 17.6 0.7 0.01 15.4 0.0 2.5 2 0 0 2 2 2 1 Baculoviridae late expression factor 5 C-terminal domain IQ_SEC7_PH PF16453.3 NM_013710.4_3 - 0.0027 17.6 0.0 0.0059 16.5 0.0 1.5 1 0 0 1 1 1 1 PH domain C1_1 PF00130.20 NM_013710.4_3 - 0.017 14.9 6.2 0.046 13.5 6.2 1.7 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PH_6 PF15406.4 NM_013710.4_3 - 0.027 14.6 0.0 0.079 13.1 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain PH_9 PF15410.4 NM_013710.4_3 - 0.028 14.7 0.0 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain EF-hand_7 PF13499.4 NM_028889.2_3 - 8.4e-09 35.7 1.1 1.8e-08 34.6 1.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_028889.2_3 - 8.6e-09 34.2 7.8 5.4e-05 22.3 1.6 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_028889.2_3 - 9.7e-07 28.1 3.5 0.00044 19.8 0.5 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 NM_028889.2_3 - 1.2e-05 24.5 3.2 0.039 13.4 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 NM_028889.2_3 - 0.0019 17.8 5.5 0.032 13.9 4.5 2.3 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_028889.2_3 - 0.089 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Ferlin_C PF16165.3 NM_001285456.1_1 - 1 9.1 5.1 1.8 8.4 5.1 1.3 1 0 0 1 1 1 0 Ferlin C-terminus SART-1 PF03343.11 NM_001285456.1_1 - 2.2 6.6 8.1 3 6.1 8.1 1.1 1 0 0 1 1 1 0 SART-1 family Tubulin-binding PF00418.17 NM_001285456.1_3 - 3.1e-42 142.1 15.4 6e-15 54.8 0.3 4.7 4 0 0 4 4 4 4 Tau and MAP protein, tubulin-binding repeat Dynamin_N PF00350.21 NM_001195674.2_1 - 6e-14 52.3 0.0 2.7e-13 50.2 0.0 2.2 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.21 NM_001195674.2_1 - 1.5e-06 28.1 0.1 3.8e-05 23.6 0.1 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.4 NM_001195674.2_1 - 0.0022 18.3 5.0 0.042 14.1 0.0 3.3 4 0 0 4 4 4 1 AAA ATPase domain ABC_tran PF00005.25 NM_001195674.2_1 - 0.0025 18.2 0.1 0.014 15.8 0.0 2.2 2 0 0 2 2 2 1 ABC transporter DUF258 PF03193.14 NM_001195674.2_1 - 0.0035 17.1 0.4 0.032 14.0 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AIG1 PF04548.14 NM_001195674.2_1 - 0.019 14.2 1.7 0.27 10.4 0.1 3.2 3 1 0 3 3 3 0 AIG1 family Amidohydro_3 PF07969.9 NM_001195674.2_1 - 0.17 11.2 0.0 0.37 10.1 0.0 1.5 1 0 0 1 1 1 0 Amidohydrolase family Ku_PK_bind PF08785.9 NM_001195674.2_1 - 0.97 9.5 5.3 2.6 8.1 0.0 3.9 4 1 1 5 5 5 0 Ku C terminal domain like HS1_rep PF02218.13 NM_001252572.1_3 - 5.7e-109 356.1 61.5 2.1e-21 76.0 2.0 6.5 6 0 0 6 6 6 6 Repeat in HS1/Cortactin SH3_9 PF14604.4 NM_001252572.1_3 - 6.5e-17 61.0 0.2 1.4e-16 60.0 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001252572.1_3 - 4.6e-16 58.0 0.2 1e-15 56.9 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001252572.1_3 - 2.2e-09 36.7 0.0 6e-09 35.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.4 NM_001252572.1_3 - 3.4e-06 27.3 5.4 12 6.2 0.0 6.0 1 1 4 6 6 6 2 TMEM210 family FadA PF09403.8 NM_001252572.1_3 - 0.22 11.9 8.4 0.45 10.9 8.4 1.4 1 0 0 1 1 1 0 Adhesion protein FadA Mnd1 PF03962.13 NM_001252572.1_3 - 0.22 11.2 4.9 0.47 10.2 4.9 1.5 1 0 0 1 1 1 0 Mnd1 family PV-1 PF06637.9 NM_001252572.1_3 - 3.8 6.1 8.0 5.8 5.5 8.0 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) Pkinase PF00069.23 NM_009158.3_3 - 1.1e-62 211.7 0.0 1.5e-62 211.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_009158.3_3 - 2.3e-28 99.1 0.1 3.4e-28 98.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_009158.3_3 - 1.9e-06 27.2 0.2 3.1e-06 26.6 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_009158.3_3 - 0.00093 18.5 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 NM_009158.3_3 - 0.003 17.1 0.3 0.0052 16.3 0.3 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 NM_009158.3_3 - 0.0045 16.8 0.0 0.0078 16.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family zf-H2C2_2 PF13465.4 NM_183185.3_3 - 1.6e-88 287.3 86.9 2.5e-08 33.9 0.3 16.2 16 0 0 16 16 16 15 Zinc-finger double domain zf-C2H2 PF00096.24 NM_183185.3_3 - 8.3e-61 199.1 110.6 9e-06 25.7 3.1 16.1 17 0 0 17 17 16 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_183185.3_3 - 9.7e-33 109.9 97.5 0.0056 17.3 0.6 15.2 15 0 0 15 15 14 13 C2H2-type zinc finger KRAB PF01352.25 NM_183185.3_3 - 7.5e-25 86.2 0.4 1.4e-24 85.4 0.4 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_183185.3_3 - 1.4e-10 40.7 81.9 0.0056 16.5 0.0 14.2 14 0 0 14 14 14 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_183185.3_3 - 3e-07 30.3 67.0 0.012 15.6 0.5 9.5 7 2 3 10 10 10 6 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_183185.3_3 - 0.0039 17.8 54.8 0.29 11.8 1.3 7.6 3 2 4 7 7 7 4 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_183185.3_3 - 0.19 12.0 61.5 0.37 11.0 0.5 12.2 13 0 0 13 13 13 0 Zinc-finger double-stranded RNA-binding Chordopox_RPO7 PF05864.10 NM_183185.3_3 - 2.2 8.4 9.9 59 3.9 0.4 5.7 6 0 0 6 6 6 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) BolA PF01722.16 NM_183185.3_3 - 2.3 8.4 16.4 5.6 7.2 0.5 5.1 4 1 1 5 5 5 0 BolA-like protein DUF3268 PF11672.6 NM_183185.3_3 - 2.3 8.4 40.7 0.43 10.8 1.1 7.1 4 1 5 9 9 9 0 zinc-finger-containing domain RHD_dimer PF16179.3 NM_001291176.1_3 - 1.3e-24 86.1 0.3 2.1e-24 85.4 0.3 1.3 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.20 NM_001291176.1_3 - 9.6e-22 77.6 0.4 2e-21 76.6 0.4 1.5 1 1 0 1 1 1 1 Rel homology DNA-binding domain TIG PF01833.22 NM_001291176.1_3 - 1.1e-06 28.5 0.0 2.5e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 IPT/TIG domain Mab-21 PF03281.12 NM_010750.3_2 - 3.5e-98 328.5 0.0 4.5e-98 328.1 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein Forkhead PF00250.16 NM_008592.2_2 - 2.6e-39 133.3 0.1 5.1e-39 132.4 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain MMR_HSR1 PF01926.21 NM_178069.5_3 - 5.1e-14 52.2 0.1 5.3e-13 48.9 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_178069.5_3 - 1.7e-09 37.7 0.2 0.0011 18.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 FeoB_N PF02421.16 NM_178069.5_3 - 5e-07 29.3 0.2 0.00026 20.4 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B AIG1 PF04548.14 NM_178069.5_3 - 0.0016 17.6 0.0 0.0035 16.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family cobW PF02492.17 NM_178069.5_3 - 0.18 11.3 3.3 0.18 11.2 0.0 2.4 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain 7tm_4 PF13853.4 NM_001159775.1_1 - 9.6e-54 182.8 25.3 1.3e-53 182.5 25.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001159775.1_1 - 2.3e-24 86.0 26.5 8.1e-24 84.1 26.5 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001159775.1_1 - 2e-05 24.0 24.1 3.3e-05 23.3 24.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx FtsJ PF01728.17 NM_001290430.1_3 - 9e-68 227.7 0.1 1.3e-67 227.2 0.1 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase MACPF PF01823.17 NM_019540.2_3 - 1.5e-27 97.0 0.0 2.2e-27 96.4 0.0 1.2 1 0 0 1 1 1 1 MAC/Perforin domain LRR_8 PF13855.4 NM_015748.3_2 - 5.6e-115 375.0 112.0 3.5e-14 52.2 2.6 11.4 4 4 8 12 12 12 12 Leucine rich repeat LRR_5 PF13306.4 NM_015748.3_2 - 2.3e-44 150.3 1.2 6.3e-10 39.0 0.2 5.9 4 1 1 5 5 5 5 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_015748.3_2 - 2.3e-40 135.6 71.8 1.5e-05 25.1 0.5 13.0 12 2 1 13 13 11 10 Leucine Rich repeats (2 copies) EGF PF00008.25 NM_015748.3_2 - 2.5e-36 123.4 143.3 7.8e-08 32.3 3.9 12.0 12 0 0 12 12 11 9 EGF-like domain Laminin_G_2 PF02210.22 NM_015748.3_2 - 4e-27 95.2 0.0 7e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 NM_015748.3_2 - 1.1e-26 93.4 0.0 1.8e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain LRRNT PF01462.16 NM_015748.3_2 - 9.8e-25 85.6 57.5 3.6e-08 32.7 1.5 9.2 8 0 0 8 8 7 4 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 NM_015748.3_2 - 1.8e-23 82.8 27.8 0.0011 18.4 0.5 7.2 4 3 3 7 7 7 7 Leucine-rich repeat LRRCT PF01463.22 NM_015748.3_2 - 6.7e-17 60.5 25.1 0.00045 20.4 0.0 7.0 7 0 0 7 7 5 4 Leucine rich repeat C-terminal domain hEGF PF12661.5 NM_015748.3_2 - 4e-12 46.2 166.9 1.8e-05 25.1 2.8 14.6 15 1 0 15 15 12 8 Human growth factor-like EGF EGF_2 PF07974.11 NM_015748.3_2 - 0.00067 19.8 13.5 0.00067 19.8 13.5 14.6 14 2 1 15 15 14 6 EGF-like domain TPKR_C2 PF16920.3 NM_015748.3_2 - 0.084 12.9 17.3 6 7.0 0.3 6.1 5 0 0 5 5 5 0 Tyrosine-protein kinase receptor C2 Ig-like domain Laminin_G_3 PF13385.4 NM_015748.3_2 - 0.12 12.4 0.3 0.24 11.4 0.3 1.4 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily LRR_1 PF00560.31 NM_015748.3_2 - 0.88 10.2 59.6 6.9 7.4 0.2 14.9 17 2 1 18 18 15 0 Leucine Rich Repeat zf-H2C2_2 PF13465.4 NM_001290350.1_3 - 1.7e-87 284.1 126.0 8.8e-10 38.5 1.1 16.2 16 1 0 16 16 16 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001290350.1_3 - 2.5e-61 200.7 120.8 1.1e-06 28.6 0.9 14.9 15 1 1 16 16 16 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001290350.1_3 - 2.4e-31 105.5 110.3 0.0042 17.7 1.0 14.8 14 1 1 15 15 15 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001290350.1_3 - 1.6e-25 88.4 84.9 1.1e-05 25.1 0.4 13.4 13 0 0 13 13 13 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001290350.1_3 - 1.5e-11 44.1 62.4 0.019 15.1 0.9 12.7 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001290350.1_3 - 1.1e-08 34.9 64.9 0.057 13.4 4.3 9.0 4 1 7 11 11 11 9 Zinc ribbon domain KRAB PF01352.25 NM_001290350.1_3 - 5.7e-08 32.2 0.0 1.3e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_11 PF16622.3 NM_001290350.1_3 - 0.24 11.1 0.0 0.24 11.1 0.0 11.3 13 0 0 13 13 13 0 zinc-finger C2H2-type zf-LYAR PF08790.9 NM_001290350.1_3 - 0.39 10.5 37.5 1.1 9.0 0.2 9.9 10 0 0 10 10 10 0 LYAR-type C2HC zinc finger XPA_N PF01286.16 NM_001290350.1_3 - 0.86 9.6 60.3 1.5 8.8 0.2 12.1 13 0 0 13 13 13 0 XPA protein N-terminal 7tm_1 PF00001.19 NM_001318922.1_3 - 2.3e-56 190.8 8.5 4.5e-56 189.9 8.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 NM_001318922.1_3 - 5.9e-09 35.5 2.7 9.9e-09 34.8 2.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 NM_001318922.1_3 - 0.0002 21.0 7.9 0.0002 21.0 7.9 2.6 2 1 0 2 2 2 1 Olfactory receptor PqiA PF04403.11 NM_001318922.1_3 - 0.33 10.6 4.9 0.44 10.2 3.2 2.0 1 1 1 2 2 2 0 Paraquat-inducible protein A RabGAP-TBC PF00566.16 NM_198647.1_3 - 1.4e-51 175.1 2.3 1.9e-51 174.6 2.3 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4502 PF14950.4 NM_198647.1_3 - 0.036 13.4 0.6 0.055 12.8 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4502) Ank_2 PF12796.5 NM_001271469.1_1 - 1.2e-12 48.2 0.0 2.3e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_001271469.1_1 - 4e-11 42.8 0.2 0.00021 21.5 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.28 NM_001271469.1_1 - 4.4e-09 36.3 0.0 0.0013 18.9 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 NM_001271469.1_1 - 9.1e-09 34.7 0.0 0.024 15.0 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 NM_001271469.1_1 - 5.9e-08 33.0 0.0 2.7e-05 24.5 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Transcrip_act PF04949.11 NM_001271469.1_1 - 0.056 13.2 1.8 0.081 12.7 1.8 1.2 1 0 0 1 1 1 0 Transcriptional activator DUF501 PF04417.10 NM_001271469.1_1 - 1 9.0 3.5 1.7 8.3 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF501) GrpE PF01025.17 NM_001271469.1_1 - 2.7 7.5 7.5 4.1 6.9 7.5 1.1 1 0 0 1 1 1 0 GrpE SHIPPO-rpt PF07004.10 NM_028961.1_3 - 0.0011 19.6 17.4 2.1 9.3 0.1 5.0 5 0 0 5 5 5 3 Sperm-tail PG-rich repeat DENN PF02141.19 NM_153551.1_3 - 1.2e-42 145.8 0.5 3.6e-42 144.3 0.5 1.7 1 1 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 NM_153551.1_3 - 1.5e-11 44.8 2.3 5.3e-11 43.0 2.3 2.0 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 NM_153551.1_3 - 6.1e-08 32.4 1.7 1.2e-07 31.4 1.7 1.6 1 0 0 1 1 1 1 dDENN domain DnaJ PF00226.29 NM_001286972.1_2 - 0.00017 21.5 0.0 0.00028 20.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain EF-hand_7 PF13499.4 NM_021344.3_2 - 8.4e-10 38.9 7.4 7e-06 26.3 1.5 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_021344.3_2 - 2.7e-07 29.5 2.6 2.2e-05 23.5 0.1 3.2 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 NM_021344.3_2 - 0.00027 20.5 1.5 0.0007 19.2 0.1 2.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.4 NM_021344.3_2 - 0.00078 18.7 0.0 0.002 17.5 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 NM_021344.3_2 - 0.002 17.7 1.2 0.023 14.3 0.5 2.7 2 1 0 2 2 2 1 EF-hand domain pair M16C_assoc PF08367.9 NM_021344.3_2 - 0.051 12.6 0.0 0.076 12.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase M16C associated Integrin_alpha PF00357.18 NM_134025.3_1 - 0.086 12.7 0.5 0.25 11.3 0.5 1.8 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region Pex2_Pex12 PF04757.12 NM_134025.3_2 - 1.2e-46 159.0 2.9 1.6e-46 158.6 2.9 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.4 NM_134025.3_2 - 0.00036 20.2 1.3 0.0007 19.3 1.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_134025.3_2 - 0.00096 19.2 1.3 0.0026 17.8 1.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_134025.3_2 - 0.0035 17.0 1.0 0.0065 16.2 1.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_134025.3_2 - 0.013 15.2 1.1 0.026 14.2 1.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.30 NM_177602.3_2 - 4e-14 52.6 19.7 0.00012 22.6 0.1 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_177602.3_2 - 4.8e-06 26.7 0.0 1.3 9.3 0.0 3.6 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain zf-H2C2_2 PF13465.4 NM_001136496.1_1 - 2.2e-76 249.0 110.1 2.6e-09 36.9 0.2 15.9 16 1 0 16 16 16 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001136496.1_1 - 1.2e-34 116.7 133.0 6.4e-06 26.2 1.0 15.1 16 1 0 16 16 16 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001136496.1_1 - 7.8e-18 63.5 118.1 0.0018 18.8 0.7 14.7 16 0 0 16 16 16 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001136496.1_1 - 1.1e-10 41.1 80.1 0.021 14.6 1.2 13.0 13 1 0 13 13 13 8 C2H2-type zinc finger BHD_1 PF10403.7 NM_001136496.1_1 - 0.0022 17.6 0.2 0.35 10.6 0.0 3.0 1 1 1 2 2 2 1 Rad4 beta-hairpin domain 1 zf-C2HE PF16278.3 NM_001136496.1_1 - 0.0077 16.5 2.2 0.0077 16.5 2.2 10.9 4 1 7 11 11 11 5 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.6 NM_001136496.1_1 - 0.013 15.7 75.3 0.033 14.4 4.4 10.2 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.4 NM_001136496.1_1 - 1.4 9.1 42.8 11 6.2 0.0 11.1 9 1 2 11 11 11 0 zinc-ribbon C1_1 PF00130.20 NM_001136496.1_1 - 3.5 7.5 57.9 1.6 8.6 2.1 9.2 2 1 9 11 11 11 0 Phorbol esters/diacylglycerol binding domain (C1 domain) KRAB PF01352.25 NM_001136496.1_2 - 9.7e-22 76.2 0.1 2.5e-21 75.0 0.1 1.7 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 NM_001136496.1_2 - 5.9e-13 48.5 9.0 9.4e-08 32.0 0.9 2.9 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001136496.1_2 - 0.00017 21.7 15.4 0.00029 21.0 5.7 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type MMS19_N PF14500.4 NM_001136496.1_2 - 0.017 14.5 1.3 4.8 6.5 0.0 2.7 2 1 1 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II zf-C2H2_6 PF13912.4 NM_001136496.1_2 - 0.16 11.8 2.2 0.39 10.6 2.2 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_001136496.1_3 - 0.0092 16.3 1.5 0.0092 16.3 1.5 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001136496.1_3 - 0.43 11.0 17.4 0.15 12.5 1.0 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type Peptidase_M24 PF00557.22 NM_011119.3_3 - 6.1e-25 88.0 0.3 8.5e-25 87.5 0.3 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 TraC PF07820.10 NM_011119.3_3 - 0.11 12.7 2.0 0.24 11.6 0.9 2.1 2 0 0 2 2 2 0 TraC-like protein Nbas_N PF15492.4 NM_027706.1_1 - 4.6e-168 557.5 0.1 7.2e-168 556.9 0.1 1.3 1 0 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal Sec39 PF08314.9 NM_027706.1_1 - 2.1e-32 112.4 5.2 3.4e-30 105.0 5.2 2.2 1 1 0 1 1 1 1 Secretory pathway protein Sec39 Reticulon PF02453.15 NM_194053.3_1 - 5.5e-46 156.2 6.6 8.6e-46 155.6 6.6 1.3 1 0 0 1 1 1 1 Reticulon RabGAP-TBC PF00566.16 NM_001290759.1_2 - 7.7e-46 156.3 0.0 1.4e-45 155.4 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.18 NM_001290759.1_2 - 6.2e-45 151.6 0.1 9.7e-25 86.5 0.0 2.4 2 0 0 2 2 2 2 GRAM domain EF-hand_1 PF00036.30 NM_001290759.1_2 - 7.8e-05 21.8 0.4 0.00023 20.3 0.1 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 NM_001290759.1_2 - 0.068 13.0 0.1 0.22 11.4 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.4 NM_001290759.1_2 - 0.14 12.6 0.0 0.37 11.2 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair DSPc PF00782.18 NM_001166390.1_3 - 5.1e-06 26.2 0.0 7.8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 NM_001166390.1_3 - 1.1e-05 25.0 0.0 1.6e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Zona_pellucida PF00100.21 NM_001146348.1_1 - 1e-08 35.1 0.5 1e-08 35.1 0.5 1.7 2 0 0 2 2 2 1 Zona pellucida-like domain RabGAP-TBC PF00566.16 NM_172443.3_1 - 9.6e-46 156.0 0.8 1.6e-45 155.3 0.8 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4723 PF15851.3 NM_001167673.1_3 - 0.25 11.4 7.3 0.4 10.7 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) HTH_Tnp_1 PF01527.18 NM_001033776.2_3 - 2.7e-10 40.3 1.7 0.00021 21.4 0.0 4.3 4 0 0 4 4 4 2 Transposase HTH_23 PF13384.4 NM_001033776.2_3 - 9.6e-07 28.3 5.1 0.019 14.6 0.1 4.1 4 0 0 4 4 4 2 Homeodomain-like domain HTH_Tnp_1_2 PF13022.4 NM_001033776.2_3 - 6.9e-06 26.1 3.3 0.086 12.9 0.0 4.0 4 0 0 4 4 4 2 Helix-turn-helix of insertion element transposase DUF1492 PF07374.9 NM_001033776.2_3 - 7.3e-05 22.7 1.2 1.4 9.0 0.0 4.0 4 0 0 4 4 4 2 Protein of unknown function (DUF1492) HTH_29 PF13551.4 NM_001033776.2_3 - 0.026 14.4 0.8 4 7.4 0.0 3.7 4 0 0 4 4 4 0 Winged helix-turn helix HTH_24 PF13412.4 NM_001033776.2_3 - 0.14 11.6 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_17 PF12728.5 NM_001033776.2_3 - 0.32 11.1 1.8 28 4.9 0.0 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_28 PF13518.4 NM_001033776.2_3 - 0.37 10.8 10.3 18 5.4 0.3 4.8 5 0 0 5 5 5 0 Helix-turn-helix domain Cnl2_NKP2 PF09447.8 NM_001033776.2_3 - 5.5 7.1 5.3 3.8 7.6 0.3 3.1 4 0 0 4 4 4 0 Cnl2/NKP2 family protein Neurexophilin PF06312.10 NM_130858.3_2 - 3.9e-96 320.4 0.1 5.3e-96 320.0 0.1 1.1 1 0 0 1 1 1 1 Neurexophilin Toxin_24 PF08094.9 NM_130858.3_2 - 0.13 12.0 6.2 0.85 9.4 6.2 2.5 1 0 0 1 1 1 0 Conotoxin TVIIA/GS family 7tm_1 PF00001.19 NM_177322.3_2 - 1.6e-50 171.7 22.6 2.5e-50 171.0 22.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_177322.3_2 - 1.2e-07 31.3 21.4 1.9e-07 30.6 21.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_177322.3_2 - 0.33 10.1 27.3 1.3 8.1 26.3 2.2 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx PWWP PF00855.15 NM_175231.2_3 - 5.5e-43 145.2 4.1 4e-22 78.4 0.7 2.9 2 0 0 2 2 2 2 PWWP domain SET PF00856.26 NM_175231.2_3 - 2.1e-21 76.9 0.3 2.1e-21 76.9 0.3 2.6 2 1 0 2 2 2 1 SET domain PHD PF00628.27 NM_175231.2_3 - 9.6e-11 41.3 71.3 2.6e-06 27.1 9.4 6.9 4 2 2 6 6 6 4 PHD-finger HMG_box PF00505.17 NM_175231.2_3 - 1.4e-10 41.3 0.0 3.3e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_175231.2_3 - 0.00043 20.7 0.1 0.001 19.5 0.1 1.6 1 0 0 1 1 1 1 HMG-box domain zf-HC5HC2H PF13771.4 NM_175231.2_3 - 0.22 11.7 66.4 0.089 12.9 1.6 6.9 4 2 3 7 7 7 0 PHD-like zinc-binding domain Na_sulph_symp PF00939.17 NM_054055.2_1 - 5.2e-107 358.7 18.9 6.7e-107 358.3 18.9 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.14 NM_054055.2_1 - 3e-36 125.0 26.7 1.5e-19 70.2 0.4 3.2 2 1 1 3 3 3 3 Citrate transporter Enterotoxin_HS1 PF08090.9 NM_054055.2_1 - 0.02 14.7 3.5 0.053 13.3 3.5 1.7 1 0 0 1 1 1 0 Heat stable E.coli enterotoxin 1 CN_hydrolase PF00795.20 NM_001308095.1_1 - 4.6e-16 58.8 0.0 6.6e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.15 NM_001308095.1_3 - 1.9e-24 86.0 0.0 7e-24 84.1 0.0 1.8 1 1 0 1 1 1 1 NAD synthase CN_hydrolase PF00795.20 NM_001308095.1_3 - 6.9e-07 28.7 0.0 1.2e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase SPRR2 PF14820.4 NM_011469.3_3 - 6.5e-18 64.7 122.0 3.2e-13 49.7 56.1 2.7 2 1 1 3 3 3 2 Small proline-rich 2 MORN PF02493.18 NM_153386.3_2 - 0.27 11.1 1.6 0.84 9.5 1.6 1.9 1 0 0 1 1 1 0 MORN repeat DUF809 PF05663.9 NM_153386.3_2 - 1.6 8.8 7.3 2.9 7.9 7.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF809) ARID PF01388.19 NM_007880.4_3 - 8.3e-20 71.1 0.0 1.5e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain TRAP_alpha PF03896.14 NM_007880.4_3 - 1.2 8.1 2.7 2.5 7.1 2.7 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.10 NM_007880.4_3 - 5 5.1 9.7 9 4.2 9.7 1.3 1 0 0 1 1 1 0 Nop14-like family TFIIA PF03153.11 NM_007880.4_3 - 6.4 6.5 14.9 5.3 6.8 3.4 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RNA_pol_3_Rpc31 PF11705.6 NM_007880.4_3 - 8.2 6.4 15.8 0.057 13.5 7.4 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 VMA21 PF09446.8 NM_001081356.3_2 - 4.9e-22 77.7 10.5 1e-21 76.7 10.5 1.6 1 0 0 1 1 1 1 VMA21-like domain Ras PF00071.20 NM_008997.3_3 - 5.1e-62 208.1 0.1 6.9e-62 207.7 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_008997.3_3 - 1e-33 115.9 0.1 1.6e-33 115.3 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_008997.3_3 - 2.5e-11 43.2 0.1 3.9e-11 42.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_008997.3_3 - 8.3e-06 25.7 0.1 1.3e-05 25.1 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 NM_008997.3_3 - 0.006 16.7 0.0 0.017 15.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.25 NM_008997.3_3 - 0.0098 15.3 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 NM_008997.3_3 - 0.014 15.2 0.3 0.27 11.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SNF2_N PF00176.21 NM_007958.1_1 - 4.6e-60 203.1 0.5 7.8e-60 202.3 0.5 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 NM_007958.1_1 - 8.7e-18 64.6 0.1 6.2e-17 61.8 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_007958.1_1 - 8.5e-10 38.8 1.3 3e-09 37.0 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 NM_007958.1_1 - 7.4e-07 28.5 0.1 1.5e-06 27.4 0.1 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.27 NM_007958.1_1 - 7.3e-05 22.5 0.0 0.00021 21.0 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase CUE PF02845.14 NM_007958.1_1 - 0.00014 21.3 0.1 0.04 13.5 0.0 2.5 2 0 0 2 2 2 2 CUE domain Pox_D5 PF03288.14 NM_007958.1_1 - 0.61 10.5 3.4 1.6 9.2 3.4 1.6 1 0 0 1 1 1 0 Poxvirus D5 protein-like DUF4211 PF13926.4 NM_175022.2_1 - 9.7e-17 61.2 0.0 2.5e-16 59.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) I-set PF07679.14 NM_001293774.1_1 - 2.3e-63 210.1 0.0 1.2e-22 79.6 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001293774.1_1 - 1.8e-44 150.1 0.0 1.4e-13 51.1 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_001293774.1_1 - 3e-31 107.3 0.3 3.1e-10 40.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_001293774.1_1 - 3e-28 97.9 0.0 3.5e-08 33.5 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_001293774.1_1 - 2.6e-12 46.7 1.3 0.02 14.9 0.0 5.4 3 2 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001293774.1_1 - 1.7e-10 40.7 0.1 0.036 14.0 0.0 3.8 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_001293774.1_1 - 0.00034 20.9 0.0 1.3 9.4 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Receptor_2B4 PF11465.6 NM_001293774.1_1 - 0.0041 17.2 0.0 0.95 9.6 0.0 3.2 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 zf-TRAF PF02176.16 NM_011633.2_1 - 1.3e-30 105.7 20.6 2.4e-17 63.3 7.5 4.5 4 1 1 5 5 4 2 TRAF-type zinc finger zf-C3HC4 PF00097.23 NM_011633.2_1 - 4.9e-06 26.2 7.8 4.9e-06 26.2 7.8 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_011633.2_1 - 5.4e-06 26.0 8.2 5.4e-06 26.0 8.2 3.7 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) Sina PF03145.14 NM_011633.2_1 - 3.1e-05 23.9 17.6 0.014 15.3 2.7 3.2 1 1 2 3 3 3 2 Seven in absentia protein family zf-C3HC4_4 PF15227.4 NM_011633.2_1 - 3.7e-05 23.7 6.4 3.7e-05 23.7 6.4 3.5 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-TRAF_2 PF15965.3 NM_011633.2_1 - 5.1e-05 23.5 6.0 5.1e-05 23.5 6.0 3.8 4 1 0 4 4 2 2 TRAF-like zinc-finger zf-RING_UBOX PF13445.4 NM_011633.2_1 - 0.00041 20.2 7.1 0.00041 20.2 7.1 3.9 3 1 1 4 4 3 1 RING-type zinc-finger Med4 PF10018.7 NM_011633.2_1 - 0.0025 17.4 2.5 0.0025 17.4 2.5 2.0 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 zf-RING_6 PF14835.4 NM_011633.2_1 - 0.006 16.3 1.9 0.033 13.9 1.9 2.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.4 NM_011633.2_1 - 0.0074 16.4 8.0 0.0074 16.4 8.0 3.8 4 1 0 4 4 1 1 Ring finger domain ATG16 PF08614.9 NM_011633.2_1 - 0.014 15.5 5.0 0.014 15.5 5.0 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Prok-RING_4 PF14447.4 NM_011633.2_1 - 0.042 13.6 10.7 0.036 13.8 7.6 2.8 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 TF_AP-2 PF03299.12 NM_011633.2_1 - 0.075 12.9 1.8 0.18 11.7 1.6 1.7 1 1 0 1 1 1 0 Transcription factor AP-2 Reo_sigmaC PF04582.10 NM_011633.2_1 - 0.086 12.1 1.5 2.4 7.3 2.7 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Exonuc_VII_L PF02601.13 NM_011633.2_1 - 0.17 11.3 6.4 0.26 10.7 6.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit BLOC1_2 PF10046.7 NM_011633.2_1 - 0.44 10.8 10.9 1.8 8.8 5.4 2.8 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.10 NM_011633.2_1 - 0.93 9.4 6.2 1.3 8.9 1.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Mod_r PF07200.11 NM_011633.2_1 - 1.6 8.7 17.4 0.1 12.6 6.9 2.4 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein betaPIX_CC PF16523.3 NM_011633.2_1 - 3 7.6 7.5 1.6 8.5 0.4 2.5 2 0 0 2 2 2 0 betaPIX coiled coil CLZ PF16526.3 NM_011633.2_1 - 3 8.1 8.4 13 6.0 4.7 2.6 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Tropomyosin_1 PF12718.5 NM_011633.2_1 - 4.2 7.3 14.9 80 3.2 14.3 2.3 1 1 0 1 1 1 0 Tropomyosin like DUF2730 PF10805.6 NM_011633.2_1 - 5.2 7.1 6.2 27 4.8 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) FlaC_arch PF05377.9 NM_011633.2_1 - 7.2 6.9 6.1 2 8.7 1.1 2.6 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Prefoldin PF02996.15 NM_011633.2_1 - 7.9 6.3 9.0 7.7 6.3 4.1 2.4 2 0 0 2 2 2 0 Prefoldin subunit 7tm_1 PF00001.19 NM_027571.3_3 - 2.3e-30 105.6 19.4 3.5e-30 105.0 19.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MHC_II_beta PF00969.17 NM_207105.3_2 - 5.3e-38 128.9 0.2 8.3e-38 128.3 0.2 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 NM_207105.3_2 - 4.6e-26 91.0 0.6 7.7e-26 90.3 0.1 1.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 NM_207105.3_2 - 9.1e-06 26.1 0.0 2.4e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 NM_207105.3_2 - 0.00012 22.0 0.1 0.00025 20.9 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain MHC_I PF00129.16 NM_207105.3_2 - 0.007 15.8 0.2 0.012 15.1 0.2 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 ig PF00047.23 NM_207105.3_2 - 0.0071 16.4 0.1 0.014 15.4 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain DUF3592 PF12158.6 NM_207105.3_2 - 0.46 10.4 2.1 0.53 10.2 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3592) PROL5-SMR PF15621.4 NM_008644.2_3 - 0.012 15.9 9.8 0.012 15.9 9.8 3.9 1 1 1 2 2 2 0 Proline-rich submaxillary gland androgen-regulated family Oxysterol_BP PF01237.16 NM_001302630.1_3 - 2e-142 474.3 0.1 2.6e-142 473.9 0.1 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein betaPIX_CC PF16523.3 NM_001302630.1_3 - 1.2 8.8 5.3 0.19 11.4 0.5 2.0 2 0 0 2 2 2 0 betaPIX coiled coil MRG PF05712.11 NM_010832.5_3 - 1.3e-63 213.8 0.5 3.6e-63 212.3 0.1 1.8 2 0 0 2 2 2 1 MRG Synaptobrevin PF00957.19 NM_016872.4_2 - 1.1e-23 82.6 0.4 1.7e-23 82.1 0.4 1.2 1 0 0 1 1 1 1 Synaptobrevin Spore_III_AB PF09548.8 NM_016872.4_2 - 0.008 16.2 1.7 0.014 15.4 1.7 1.3 1 0 0 1 1 1 1 Stage III sporulation protein AB (spore_III_AB) SKG6 PF08693.8 NM_016872.4_2 - 3.1 7.2 8.9 5.7 6.3 8.9 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain ATP-synt_ab PF00006.23 NM_007505.2_2 - 1.4e-74 250.3 0.0 2.1e-74 249.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.25 NM_007505.2_2 - 3.1e-47 159.9 1.2 4.7e-47 159.3 1.2 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.21 NM_007505.2_2 - 2.4e-16 59.8 1.5 5.4e-16 58.7 1.5 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF4142 PF13628.4 NM_007505.2_2 - 0.00097 19.3 0.4 0.0019 18.3 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4142) zf-H2C2_2 PF13465.4 NM_001048204.1_3 - 1.2e-64 211.8 95.8 2.5e-07 30.7 1.8 13.1 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001048204.1_3 - 1.5e-45 151.0 109.6 2.2e-06 27.7 1.3 12.0 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001048204.1_3 - 2.7e-24 83.6 115.9 0.0029 18.2 2.7 13.0 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_001048204.1_3 - 2.1e-22 78.4 0.4 4e-22 77.5 0.4 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_11 PF16622.3 NM_001048204.1_3 - 1.5e-17 62.9 71.7 7.9e-06 25.4 2.9 11.1 11 0 0 11 11 11 7 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 NM_001048204.1_3 - 0.00055 20.1 63.2 0.03 14.5 5.7 7.5 1 1 7 8 8 8 5 C2H2-type zinc ribbon zf-C2H2_6 PF13912.4 NM_001048204.1_3 - 0.0018 18.0 1.1 0.0018 18.0 1.1 11.4 11 0 0 11 11 11 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001048204.1_3 - 0.003 17.7 64.8 0.42 10.9 1.2 11.4 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding BHD_1 PF10403.7 NM_001048204.1_3 - 0.021 14.5 6.4 5.6 6.7 0.0 5.6 6 1 1 7 7 7 0 Rad4 beta-hairpin domain 1 zf-met PF12874.5 NM_001048204.1_3 - 0.029 14.6 0.6 0.029 14.6 0.6 9.9 9 0 0 9 9 9 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 NM_001048204.1_3 - 0.038 14.0 70.9 0.059 13.4 5.7 7.3 5 2 4 9 9 9 0 Zinc ribbon domain zf-RING_7 PF02591.13 NM_001048204.1_3 - 8 6.6 34.0 12 6.1 0.0 8.0 8 0 0 8 8 8 0 C4-type zinc ribbon domain Scs3p PF10261.7 NM_026808.1_3 - 1.1e-12 47.8 21.2 1.1e-05 24.9 6.8 3.1 1 1 0 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM tRNA-synt_2b PF00587.23 NM_023637.3_1 - 3.3e-23 82.4 0.0 5e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.20 NM_023637.3_1 - 7e-07 29.3 1.1 1.1e-06 28.7 1.1 1.3 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Mod_r PF07200.11 NM_023637.3_1 - 0.011 15.7 2.1 0.02 14.9 2.1 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF2312 PF10073.7 NM_023637.3_1 - 0.1 12.1 0.4 0.19 11.3 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) HalX PF08663.8 NM_023637.3_1 - 0.34 11.1 2.2 0.92 9.7 0.1 2.2 1 1 1 2 2 2 0 HalX domain FUSC PF04632.10 NM_023637.3_1 - 2.8 6.3 4.5 4 5.7 4.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family zf-H2C2_2 PF13465.4 NM_001085415.1_1 - 8.5e-57 187.1 98.1 3.2e-08 33.5 1.7 15.5 16 0 0 16 16 15 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001085415.1_1 - 1.5e-48 160.5 106.7 3.7e-05 23.8 3.8 12.7 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001085415.1_1 - 2.7e-30 102.3 100.6 0.0032 18.0 2.9 12.9 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001085415.1_1 - 2.9e-07 30.5 36.5 0.1 12.8 0.2 10.5 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001085415.1_1 - 9.5e-05 22.1 84.6 0.049 13.5 1.1 13.1 13 1 0 13 13 13 5 C2H2-type zinc finger Yippee-Mis18 PF03226.12 NM_001085415.1_1 - 0.0036 17.3 0.0 0.0036 17.3 0.0 5.0 5 1 1 6 6 4 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-H2C2_5 PF13909.4 NM_001085415.1_1 - 0.0073 15.9 1.9 0.0073 15.9 1.9 9.9 10 0 0 10 10 9 1 C2H2-type zinc-finger domain FAM217 PF15344.4 NM_001085415.1_1 - 0.11 12.3 0.1 0.11 12.3 0.1 3.0 3 0 0 3 3 3 0 FAM217 family DUF4712 PF15830.3 NM_001085415.1_1 - 0.19 11.3 0.6 0.63 9.6 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4712) zf-met PF12874.5 NM_001085415.1_1 - 0.31 11.4 67.7 0.57 10.5 1.1 11.0 11 0 0 11 11 11 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 NM_001085415.1_1 - 0.35 10.9 57.4 0.26 11.3 4.0 8.9 4 2 6 10 10 10 0 Zinc ribbon domain zf-LYAR PF08790.9 NM_001085415.1_1 - 1 9.2 32.4 9.4 6.1 0.1 10.0 10 0 0 10 10 10 0 LYAR-type C2HC zinc finger zinc_ribbon_15 PF17032.3 NM_001085415.1_1 - 2.1 9.0 35.0 2.7 8.7 0.3 7.1 5 1 1 7 7 7 0 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_001085415.1_1 - 6.6 6.4 82.3 0.064 12.9 1.6 11.9 12 0 0 12 12 12 0 zinc-finger C2H2-type Filament PF00038.19 NM_001131020.1_3 - 4e-109 364.9 51.0 4.7e-109 364.6 51.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 NM_001131020.1_3 - 6.4e-06 26.8 0.9 1.3e-05 25.8 0.9 1.5 1 0 0 1 1 1 1 Intermediate filament head (DNA binding) region DUF1664 PF07889.10 NM_001131020.1_3 - 0.0019 18.0 10.7 0.094 12.6 0.4 3.0 2 1 0 3 3 3 2 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.10 NM_001131020.1_3 - 0.025 13.9 3.9 1.1 8.5 0.5 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Spc7 PF08317.9 NM_001131020.1_3 - 0.37 9.5 45.3 0.37 9.5 11.0 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 NM_001131020.1_3 - 1.9 8.5 47.7 0.23 11.6 15.3 3.3 2 1 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.4 NM_001131020.1_3 - 5.1 6.2 34.0 1.4 8.1 14.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.8 NM_001131020.1_3 - 9.1 6.3 19.9 1.6 8.8 4.9 3.0 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family RRM_1 PF00076.20 NM_001078167.2_2 - 8.3e-32 108.7 0.0 4.6e-16 58.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 NM_001078167.2_2 - 0.0028 17.4 0.0 0.02 14.7 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.3 NM_001078167.2_2 - 0.0074 16.0 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.9 NM_001078167.2_2 - 0.053 13.4 0.0 0.79 9.7 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif RRM_7 PF16367.3 NM_001078167.2_2 - 0.084 12.9 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif Cadherin PF00028.15 NM_033585.1_1 - 1.5e-85 281.6 0.1 6e-19 68.2 0.3 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_033585.1_1 - 2.3e-35 120.1 0.1 1.2e-32 111.4 0.0 4.2 6 0 0 6 6 6 1 Cadherin-like Cadherin_tail PF15974.3 NM_033585.1_1 - 8.3e-26 90.8 2.8 1.6e-25 89.9 2.8 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 NM_033585.1_1 - 1.2e-24 86.7 0.0 3.6e-24 85.2 0.0 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 NM_033585.1_1 - 0.0051 16.7 1.6 4.6 7.2 0.0 4.1 4 0 0 4 4 4 1 Cadherin-like IL1 PF00340.17 NM_031167.5_1 - 1.7e-38 130.8 0.2 4.4e-38 129.5 0.0 1.8 3 0 0 3 3 3 1 Interleukin-1 / 18 P2X_receptor PF00864.17 NM_001038839.2_2 - 2.6e-155 516.9 6.1 3.2e-155 516.6 6.1 1.1 1 0 0 1 1 1 1 ATP P2X receptor 7tm_4 PF13853.4 NM_146584.2_1 - 1.8e-57 195.1 21.8 2.1e-57 194.9 21.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146584.2_1 - 1.6e-24 86.5 21.0 2.7e-24 85.7 21.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CPSase_L_D2 PF02786.15 NM_001289522.1_2 - 5.3e-112 372.3 0.1 2.5e-83 278.6 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.20 NM_001289522.1_2 - 3.5e-50 169.0 0.0 6.4e-50 168.1 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.26 NM_001289522.1_2 - 1.9e-45 154.8 0.0 5e-45 153.5 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.17 NM_001289522.1_2 - 5.6e-39 133.1 0.0 1e-38 132.2 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.22 NM_001289522.1_2 - 4.5e-34 117.7 0.0 9.2e-34 116.7 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ATP-grasp PF02222.20 NM_001289522.1_2 - 2.2e-20 72.8 0.1 3e-10 39.8 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.20 NM_001289522.1_2 - 9.5e-18 64.0 0.0 3.4e-17 62.3 0.0 2.0 2 0 0 2 2 2 1 MGS-like domain ATPgrasp_Ter PF15632.4 NM_001289522.1_2 - 1.8e-16 59.6 0.0 0.00033 19.3 0.0 4.1 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.11 NM_001289522.1_2 - 4e-16 59.0 0.1 3.4e-08 33.1 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus OTCace_N PF02729.19 NM_001289522.1_2 - 4.9e-12 45.9 0.1 6.8e-09 35.7 0.0 2.7 1 1 1 2 2 2 2 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Amidohydro_1 PF01979.18 NM_001289522.1_2 - 2.8e-11 43.2 1.0 6.6e-10 38.7 0.1 3.4 3 1 0 3 3 3 1 Amidohydrolase family ATP-grasp_3 PF02655.12 NM_001289522.1_2 - 8.3e-06 25.8 0.0 0.052 13.4 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.11 NM_001289522.1_2 - 0.00025 20.8 3.0 0.02 14.5 0.4 3.3 2 1 0 2 2 2 1 Peptidase C26 ATP-grasp_5 PF13549.4 NM_001289522.1_2 - 0.0039 16.6 0.0 2.7 7.3 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.17 NM_001289522.1_2 - 0.0067 16.1 0.0 0.044 13.4 0.0 2.1 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RAWUL PF16207.3 NM_009545.2_2 - 9.8e-22 77.3 0.6 1.7e-21 76.5 0.6 1.4 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 NM_009545.2_2 - 3.6e-10 39.4 7.7 9.6e-10 38.0 7.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_009545.2_2 - 1.6e-09 37.3 8.0 4.3e-09 36.0 8.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_009545.2_2 - 7.5e-07 29.2 6.5 2.8e-06 27.4 6.5 2.1 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.5 NM_009545.2_2 - 1.7e-05 24.9 4.0 4.7e-05 23.5 4.0 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.4 NM_009545.2_2 - 2.2e-05 24.1 7.2 2.2e-05 24.1 7.2 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_009545.2_2 - 0.00019 21.2 7.7 0.0005 19.8 7.7 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_009545.2_2 - 0.0012 18.7 4.7 0.0044 16.9 4.7 2.1 1 0 0 1 1 1 1 RING-type zinc-finger Rad60-SLD PF11976.6 NM_009545.2_2 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like zf-Nse PF11789.6 NM_009545.2_2 - 0.2 11.4 4.2 0.47 10.2 4.2 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.5 NM_009545.2_2 - 0.2 11.6 3.2 0.37 10.7 3.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.3 NM_009545.2_2 - 0.67 10.0 6.8 0.77 9.8 4.9 2.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.4 NM_009545.2_2 - 0.94 9.6 15.0 0.07 13.2 9.2 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Trypan_PARP PF05887.9 NM_028629.1_2 - 5.4 6.9 60.2 0.87 9.5 27.2 2.6 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) Ery_res_leader2 PF08057.9 NM_028629.1_3 - 0.46 10.9 2.9 1.1e+02 3.7 0.1 4.9 4 0 0 4 4 4 0 Erythromycin resistance leader peptide 7tm_4 PF13853.4 NM_146447.1_1 - 3.8e-36 125.1 17.3 5.2e-36 124.7 17.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146447.1_1 - 1.8e-18 66.6 24.8 1.8e-18 66.6 24.8 2.1 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) AhpC-TSA PF00578.19 NM_007452.2_3 - 7.5e-37 125.9 0.0 1.1e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 NM_007452.2_3 - 3.6e-16 59.0 0.0 5.5e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.7 NM_007452.2_3 - 2.7e-13 49.4 0.1 4.8e-13 48.6 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Lectin_C PF00059.19 NM_139134.3_2 - 5.2e-15 56.0 0.2 1.1e-14 55.0 0.2 1.6 1 0 0 1 1 1 1 Lectin C-type domain Laminin_II PF06009.10 NM_144837.3_2 - 0.0033 17.3 3.4 0.0033 17.3 3.4 2.5 1 1 1 2 2 2 1 Laminin Domain II 7tm_4 PF13853.4 NM_147105.2_1 - 3.3e-55 187.7 14.5 4.3e-55 187.3 14.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147105.2_1 - 8.8e-24 84.0 16.0 1.5e-23 83.2 16.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147105.2_1 - 0.0014 18.0 8.4 0.0014 18.0 8.4 2.3 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srsx Rad60-SLD PF11976.6 NM_009460.2_3 - 1.1e-20 73.0 0.1 1.8e-20 72.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 NM_009460.2_3 - 2.1e-17 62.5 0.5 3.7e-17 61.7 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin family HNF-1B_C PF04812.11 NM_009327.3_3 - 6.8e-93 310.8 27.2 6.8e-93 310.8 27.2 1.7 2 0 0 2 2 2 1 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus HNF-1_N PF04814.11 NM_009327.3_3 - 1.4e-54 185.6 0.2 5e-54 183.8 0.0 2.1 2 0 0 2 2 2 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus HNF-1A_C PF04813.10 NM_009327.3_3 - 1.3e-34 118.7 15.4 1.3e-34 118.7 15.4 2.8 3 0 0 3 3 3 1 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus Homeobox PF00046.27 NM_009327.3_3 - 5e-06 26.1 0.2 1.7e-05 24.4 0.2 1.9 1 1 0 1 1 1 1 Homeobox domain Telethonin PF09470.8 NM_009327.3_3 - 0.016 15.0 0.4 0.033 14.0 0.4 1.4 1 0 0 1 1 1 0 Telethonin protein Homeobox_KN PF05920.9 NM_009327.3_3 - 0.045 13.5 0.0 0.15 11.9 0.0 1.9 1 0 0 1 1 1 0 Homeobox KN domain Jacalin PF01419.15 NM_001039238.2_2 - 0.00094 19.0 0.1 0.0014 18.4 0.1 1.2 1 0 0 1 1 1 1 Jacalin-like lectin domain GNT-I PF03071.13 NM_001110149.1_3 - 8.7e-203 673.8 0.0 1e-202 673.5 0.0 1.0 1 0 0 1 1 1 1 GNT-I family MHC_I PF00129.16 NM_010394.4_1 - 1.6e-94 314.4 1.9 2e-94 314.0 1.9 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_010394.4_1 - 1.5e-15 57.3 0.0 2.8e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ig PF00047.23 NM_010394.4_1 - 0.00023 21.1 0.0 0.00045 20.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_010394.4_1 - 0.00059 20.3 0.2 0.41 11.2 0.0 2.6 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 NM_010394.4_1 - 0.016 15.2 0.3 0.044 13.7 0.0 1.8 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 NM_010394.4_1 - 0.032 14.4 0.0 0.066 13.4 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain NAD_binding_4 PF07993.10 NM_178797.3_3 - 1.2e-73 247.4 0.0 1.9e-73 246.7 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.17 NM_178797.3_3 - 3.6e-33 113.5 0.7 7.1e-33 112.5 0.7 1.5 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.19 NM_178797.3_3 - 4.2e-07 29.6 0.0 1.7e-06 27.6 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.13 NM_178797.3_3 - 1.1e-05 24.6 0.1 1.9e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.17 NM_178797.3_3 - 3.8e-05 22.7 0.0 0.0001 21.3 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.22 NM_178797.3_3 - 0.0016 18.8 0.0 0.0026 18.1 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.15 NM_178797.3_3 - 0.006 15.6 0.3 3.9 6.4 0.2 3.5 3 1 0 3 3 3 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.3 NM_178797.3_3 - 0.012 14.9 0.1 0.024 13.9 0.1 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase MRP PF09387.8 NM_001256117.1_3 - 3.9e-95 317.3 3.5 5.8e-95 316.8 3.5 1.3 1 0 0 1 1 1 1 Mitochondrial RNA binding protein MRP Sad1_UNC PF07738.11 NM_001256117.1_3 - 1.1e-45 154.9 0.0 1.9e-45 154.1 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Lectin_N PF03954.12 NM_001256117.1_3 - 0.0025 17.4 1.3 0.17 11.5 0.6 2.6 2 0 0 2 2 2 1 Hepatic lectin, N-terminal domain JAKMIP_CC3 PF16034.3 NM_001256117.1_3 - 0.028 14.2 5.6 0.06 13.2 5.6 1.4 1 0 0 1 1 1 0 JAKMIP CC3 domain V_ATPase_I PF01496.17 NM_001256117.1_3 - 0.29 8.8 2.0 0.4 8.4 2.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Allexi_40kDa PF05549.9 NM_001256117.1_3 - 0.35 10.2 2.3 0.86 8.9 2.3 1.6 1 0 0 1 1 1 0 Allexivirus 40kDa protein Mnd1 PF03962.13 NM_001256117.1_3 - 1.8 8.2 7.9 0.67 9.7 4.9 1.6 2 0 0 2 2 2 0 Mnd1 family Astro_capsid_N PF03115.12 NM_001256117.1_3 - 2.1 6.9 5.8 0.51 8.9 2.2 1.7 2 0 0 2 2 2 0 Astrovirus capsid protein precursor FKBP_C PF00254.26 NM_001302080.1_3 - 1.5e-27 95.6 0.0 2.3e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase BCL_N PF04714.11 NM_029850.3_3 - 1.1e-27 95.7 7.3 1.1e-27 95.7 7.3 1.8 2 0 0 2 2 2 1 BCL7, N-terminal conserver region Ras PF00071.20 NM_001293653.1_3 - 4.1e-57 192.2 0.1 5.7e-57 191.7 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001293653.1_3 - 2.6e-31 108.2 0.0 4.6e-31 107.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001293653.1_3 - 1.2e-12 47.5 0.0 1.9e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001293653.1_3 - 1.7e-06 28.0 0.0 2.9e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_001293653.1_3 - 4.5e-05 22.8 0.0 7e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 NM_001293653.1_3 - 4.9e-05 23.1 0.0 0.012 15.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_001293653.1_3 - 0.00056 19.4 0.0 0.012 15.1 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Septin PF00735.16 NM_001293653.1_3 - 0.032 13.4 0.2 0.1 11.7 0.1 1.8 2 0 0 2 2 2 0 Septin cobW PF02492.17 NM_001293653.1_3 - 0.033 13.6 0.0 0.072 12.5 0.0 1.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.4 NM_001293653.1_3 - 0.037 14.2 0.0 0.08 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 NM_001293653.1_3 - 0.095 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 NM_001293653.1_3 - 0.096 12.9 0.0 0.21 11.8 0.0 1.5 2 0 0 2 2 1 0 AAA ATPase domain PduV-EutP PF10662.7 NM_001293653.1_3 - 0.099 12.3 0.1 0.54 9.9 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.8 NM_001293653.1_3 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit V-SNARE_C PF12352.6 NM_016800.3_2 - 2.2e-20 72.6 8.0 2.2e-20 72.6 8.0 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.13 NM_016800.3_2 - 3.5e-18 65.6 0.4 3.5e-18 65.6 0.4 2.1 2 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.11 NM_016800.3_2 - 9.9e-07 28.5 1.1 3e-06 26.9 1.2 1.7 2 0 0 2 2 2 1 Sec20 Laminin_II PF06009.10 NM_016800.3_2 - 0.0023 17.8 4.2 0.041 13.8 1.0 2.7 2 1 1 3 3 3 1 Laminin Domain II YqjK PF13997.4 NM_016800.3_2 - 0.0024 17.9 1.6 1.2 9.3 0.6 2.5 2 0 0 2 2 2 2 YqjK-like protein DUF3376 PF11856.6 NM_016800.3_2 - 0.052 12.4 2.3 0.05 12.4 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3376) KxDL PF10241.7 NM_016800.3_2 - 1.7 8.8 9.7 4 7.6 0.3 3.3 3 1 1 4 4 4 0 Uncharacterized conserved protein OmpH PF03938.12 NM_016800.3_2 - 1.8 8.5 5.8 0.5 10.2 0.3 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) CAP_N PF01213.17 NM_016800.3_3 - 0.12 11.7 1.7 0.16 11.3 1.7 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal zf-C2H2 PF00096.24 NM_010637.3_2 - 5.5e-15 54.8 23.2 2.7e-05 24.2 2.9 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_010637.3_2 - 1.2e-09 38.1 11.2 9.5e-07 28.9 3.4 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_010637.3_2 - 4.9e-07 29.9 19.8 0.032 14.9 2.7 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.3 NM_010637.3_2 - 1.9 9.0 6.3 24 5.5 2.0 3.0 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-met PF12874.5 NM_010637.3_2 - 4.9 7.5 7.9 7.5 6.9 1.3 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type JmjC PF02373.20 NM_177201.5_3 - 1.7e-11 44.4 0.5 8e-11 42.3 0.5 2.0 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.27 NM_177201.5_3 - 1.3e-08 34.4 6.6 3.1e-08 33.3 6.6 1.7 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.4 NM_177201.5_3 - 1.6e-08 34.5 0.0 5.2e-08 32.9 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain PHD_4 PF16866.3 NM_177201.5_3 - 0.33 10.9 4.2 0.98 9.4 4.2 1.7 1 0 0 1 1 1 0 PHD-finger PHD_2 PF13831.4 NM_177201.5_3 - 0.64 9.5 9.4 0.013 14.8 2.5 1.9 2 0 0 2 2 2 0 PHD-finger TSGP1 PF07771.9 NM_177201.5_3 - 2.8 8.0 5.6 9.4 6.3 1.1 2.5 2 0 0 2 2 2 0 Tick salivary peptide group 1 Hormone_1 PF00103.18 NM_181852.2_1 - 5.6e-71 238.6 1.5 6.6e-71 238.3 1.5 1.0 1 0 0 1 1 1 1 Somatotropin hormone family 7tm_4 PF13853.4 NM_207152.2_1 - 3.6e-54 184.3 21.0 4.4e-54 184.0 21.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207152.2_1 - 1.6e-25 89.7 25.3 1.6e-25 89.7 25.3 1.8 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_207152.2_1 - 1.2e-07 31.3 21.9 2.4e-07 30.3 21.9 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Glycoprotein_G PF00802.17 NM_207152.2_1 - 0.12 11.6 2.8 0.19 11.0 2.8 1.2 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G Histone PF00125.22 NM_178203.2_1 - 1.1e-54 184.3 2.4 1.2e-54 184.1 2.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 NM_178203.2_1 - 3.8e-05 23.6 0.1 7.4e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.4 NM_178203.2_1 - 0.00051 20.2 0.0 0.00078 19.6 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.21 NM_178203.2_1 - 0.014 15.5 0.1 0.027 14.6 0.1 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PAF PF15715.3 NM_178203.2_1 - 0.032 14.7 1.2 0.049 14.1 1.2 1.3 1 0 0 1 1 1 0 PCNA-associated factor TFIID-31kDa PF02291.13 NM_178203.2_1 - 0.11 12.4 0.1 0.19 11.7 0.0 1.4 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit ADH_zinc_N PF00107.24 NM_026994.1_3 - 8.1e-07 28.9 0.1 2e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 NM_026994.1_3 - 0.11 13.4 0.0 0.25 12.2 0.0 1.7 1 1 0 1 1 1 0 Zinc-binding dehydrogenase eIF-5_eIF-2B PF01873.15 NM_173363.5_2 - 8.9e-42 141.5 0.3 3.2e-41 139.8 0.1 2.0 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.16 NM_173363.5_2 - 2e-21 75.8 1.5 2e-21 75.8 1.5 2.0 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon NAD_Gly3P_dh_N PF01210.21 NM_010271.2_1 - 4.3e-55 185.8 0.2 8.2e-55 184.9 0.1 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.12 NM_010271.2_1 - 1.2e-48 164.8 0.1 1.8e-48 164.2 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.15 NM_010271.2_1 - 0.0052 17.2 0.4 0.1 13.1 0.4 2.5 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent SRP72 PF08492.10 NM_025691.1_3 - 5.2e-22 77.9 10.1 5.2e-22 77.9 10.1 2.5 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.4 NM_025691.1_3 - 9.8e-22 77.1 10.7 0.00025 21.4 0.0 6.5 4 2 3 7 7 7 6 Tetratricopeptide repeat SRP_TPR_like PF17004.3 NM_025691.1_3 - 4.2e-21 75.0 4.2 4.2e-21 75.0 4.2 3.3 3 1 0 3 3 3 1 Putative TPR-like repeat TPR_14 PF13428.4 NM_025691.1_3 - 1.4e-14 53.4 2.1 0.25 12.1 0.0 7.2 6 1 1 7 7 6 3 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_025691.1_3 - 4.4e-14 52.3 18.3 4.7e-05 23.4 2.3 6.4 5 2 1 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.15 NM_025691.1_3 - 1e-12 47.0 12.4 0.0034 17.2 0.0 8.1 8 1 1 9 9 8 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_025691.1_3 - 2.1e-10 40.6 14.7 0.0021 18.2 1.1 6.6 5 2 1 6 6 5 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_025691.1_3 - 6.6e-09 35.2 13.8 0.033 14.3 0.2 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_025691.1_3 - 3.3e-08 33.4 0.5 0.23 11.5 0.0 5.8 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_025691.1_3 - 1.6e-07 30.7 10.3 0.018 14.8 0.0 7.3 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_025691.1_3 - 4.6e-06 27.1 0.0 4.9 7.8 0.1 6.2 5 1 2 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_025691.1_3 - 4.9e-06 26.7 19.7 0.48 11.0 0.1 7.9 9 0 0 9 9 9 2 Tetratricopeptide repeat HrpB1_HrpK PF09613.8 NM_025691.1_3 - 2.3e-05 23.9 4.2 0.00059 19.3 0.2 4.2 4 2 1 5 5 4 1 Bacterial type III secretion protein (HrpB1_HrpK) BTAD PF03704.15 NM_025691.1_3 - 4.7e-05 23.7 7.6 0.013 15.8 0.2 4.1 4 1 0 4 4 4 2 Bacterial transcriptional activator domain PPR PF01535.18 NM_025691.1_3 - 0.00015 21.6 0.0 47 4.4 0.0 6.1 6 0 0 6 6 6 0 PPR repeat SNAP PF14938.4 NM_025691.1_3 - 0.00023 20.5 13.6 0.00075 18.9 0.2 3.9 3 1 1 4 4 4 2 Soluble NSF attachment protein, SNAP ATP13 PF12921.5 NM_025691.1_3 - 0.0004 20.1 0.6 3.5 7.4 0.0 4.7 4 1 1 5 5 4 1 Mitochondrial ATPase expression TPR_11 PF13414.4 NM_025691.1_3 - 0.00073 19.0 9.1 0.058 12.9 0.1 5.6 8 0 0 8 8 7 1 TPR repeat TPR_10 PF13374.4 NM_025691.1_3 - 0.03 14.1 5.2 2.3 8.1 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF627 PF04781.10 NM_025691.1_3 - 0.035 14.0 1.6 0.24 11.3 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF627) TPR_4 PF07721.12 NM_025691.1_3 - 0.097 13.2 0.5 12 6.7 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat CCDC-167 PF15188.4 NM_025691.1_3 - 0.81 9.9 3.3 1 9.6 0.3 2.5 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 HemY_N PF07219.11 NM_025691.1_3 - 6.4 6.9 8.5 17 5.5 0.0 3.8 5 0 0 5 5 4 0 HemY protein N-terminus RabGAP-TBC PF00566.16 NM_198664.3_1 - 1.6e-51 174.9 0.0 2.6e-51 174.2 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH PF00169.27 NM_198664.3_1 - 1.4e-10 41.5 0.1 2.7e-10 40.5 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_198664.3_1 - 0.0009 19.5 0.0 0.0026 18.0 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 NM_198664.3_1 - 0.0019 18.3 0.2 0.0042 17.2 0.0 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain PTPlike_phytase PF14566.4 NM_198664.3_1 - 0.15 12.0 1.8 0.37 10.8 1.8 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Fer4 PF00037.25 NM_198664.3_3 - 0.29 10.9 2.8 0.69 9.7 2.8 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain ELL PF10390.7 NM_138953.2_3 - 2e-109 365.3 0.2 2e-109 365.3 0.2 2.1 2 0 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.11 NM_138953.2_3 - 4.7e-33 113.8 10.7 4.7e-33 113.8 10.7 2.1 2 0 0 2 2 2 1 Occludin homology domain RhoGAP PF00620.25 NM_153820.3_3 - 2.5e-51 173.3 0.4 1.2e-50 171.1 0.0 2.3 3 0 0 3 3 3 1 RhoGAP domain PH PF00169.27 NM_153820.3_3 - 3e-11 43.6 2.5 5e-11 42.9 0.6 2.2 2 0 0 2 2 2 1 PH domain PH_9 PF15410.4 NM_153820.3_3 - 2.7e-05 24.4 1.4 4.3e-05 23.7 0.3 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain RPEL PF02755.13 NM_153820.3_3 - 0.092 12.4 0.5 0.25 11.0 0.5 1.8 1 0 0 1 1 1 0 RPEL repeat Pkinase PF00069.23 NM_001168513.1_3 - 1.5e-58 198.1 0.1 2.1e-58 197.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001168513.1_3 - 1.2e-26 93.4 0.0 1.9e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_001168513.1_3 - 0.00031 20.0 0.3 0.00048 19.4 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001168513.1_3 - 0.045 13.5 0.1 0.12 12.1 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Cadherin PF00028.15 NM_007665.3_3 - 2.6e-76 252.0 3.1 5.1e-20 71.6 0.1 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 NM_007665.3_3 - 1.9e-44 151.0 0.0 4.2e-44 149.9 0.0 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.10 NM_007665.3_3 - 0.0016 18.1 0.0 4.5 7.0 0.0 3.7 3 0 0 3 3 3 2 Cadherin-like Cadherin_3 PF16184.3 NM_007665.3_3 - 0.0062 16.4 5.5 0.15 12.0 0.1 3.7 3 1 1 4 4 4 1 Cadherin-like Calycin_like PF13944.4 NM_007665.3_3 - 0.84 9.9 5.4 0.62 10.3 1.5 2.5 1 1 0 2 2 2 0 Calycin-like beta-barrel domain RAI16-like PF10257.7 NM_001242363.2_1 - 2e-94 316.3 0.3 3.3e-94 315.6 0.3 1.4 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein SUIM_assoc PF16619.3 NM_001242363.2_1 - 0.35 10.8 10.2 0.75 9.8 10.2 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 AP3D1 PF06375.9 NM_001177380.1_3 - 1.5 9.0 12.0 2 8.5 12.0 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 PPARgamma_N PF12577.6 NM_001127330.2_2 - 2.2e-32 111.4 1.1 5.5e-32 110.1 1.1 1.7 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.16 NM_001127330.2_2 - 2.6e-27 94.9 15.0 4.5e-27 94.2 15.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001127330.2_2 - 4.1e-15 55.8 0.4 9.4e-15 54.6 0.4 1.6 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 NM_001127330.2_2 - 0.03 13.3 2.7 0.049 12.6 2.7 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A zf-C2H2 PF00096.24 NM_178803.2_2 - 3.8e-06 26.9 8.3 0.92 10.0 1.2 4.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_178803.2_2 - 0.00033 20.8 0.0 0.0021 18.3 0.0 2.6 1 0 0 1 1 1 1 Zinc-finger double domain DUF4764 PF15961.3 NM_178803.2_2 - 0.07 11.7 0.4 0.099 11.2 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4764) zf-C2H2_4 PF13894.4 NM_178803.2_2 - 8.7 7.3 24.2 0.99 10.3 0.1 5.5 5 0 0 5 5 5 0 C2H2-type zinc finger Voltage_CLC PF00654.18 NM_011929.3_2 - 1.2e-98 330.5 24.2 2.9e-98 329.2 20.9 2.2 2 0 0 2 2 2 2 Voltage gated chloride channel CBS PF00571.26 NM_011929.3_2 - 4.2e-15 55.8 0.4 4.9e-09 36.4 0.0 3.0 3 0 0 3 3 3 2 CBS domain Asp PF00026.21 NM_025973.3_2 - 3.7e-116 387.8 3.2 4.5e-116 387.5 3.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 NM_025973.3_2 - 2.3e-16 60.4 9.2 5.9e-10 39.6 0.5 2.7 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 NM_025973.3_2 - 2.3e-14 52.8 1.2 4e-14 52.0 1.2 1.4 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.4 NM_025973.3_2 - 3.8e-05 23.3 0.0 0.0002 21.0 0.0 2.2 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.4 NM_025973.3_2 - 0.0055 17.2 0.0 3.4 8.3 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.4 NM_025973.3_2 - 0.12 12.8 0.0 18 5.8 0.0 2.4 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Ctr PF04145.13 NM_001290518.1_1 - 4.8e-28 98.5 1.9 4.8e-28 98.5 1.9 1.5 2 0 0 2 2 2 1 Ctr copper transporter family Ank_2 PF12796.5 NM_029898.3_1 - 9.1e-40 135.0 0.5 1.1e-11 45.1 0.1 4.5 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_029898.3_1 - 8e-33 112.3 5.5 9.2e-09 35.5 0.1 7.0 2 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_029898.3_1 - 7.4e-31 105.6 6.4 1.6e-07 31.4 0.0 6.3 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 NM_029898.3_1 - 3.6e-27 93.4 5.8 1.1e-05 25.5 0.0 8.4 8 0 0 8 8 8 5 Ankyrin repeat Ank_3 PF13606.4 NM_029898.3_1 - 4.4e-26 88.0 0.5 0.00027 21.0 0.0 7.8 7 0 0 7 7 7 4 Ankyrin repeat LRR_8 PF13855.4 NM_008438.3_2 - 1.7e-30 104.4 31.0 6.5e-11 41.7 6.1 6.8 4 2 3 7 7 7 7 Leucine rich repeat LRR_4 PF12799.5 NM_008438.3_2 - 9e-12 44.8 34.4 0.00055 20.1 2.8 7.5 4 1 4 8 8 8 7 Leucine Rich repeats (2 copies) LRRNT PF01462.16 NM_008438.3_2 - 8.2e-07 28.4 3.3 8.2e-07 28.4 3.3 2.0 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 NM_008438.3_2 - 4.6e-05 22.9 14.7 0.033 13.6 2.3 3.8 1 1 3 4 4 4 3 Leucine-rich repeat LRR_5 PF13306.4 NM_008438.3_2 - 0.0002 21.2 0.4 0.009 15.8 0.1 2.7 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_6 PF13516.4 NM_008438.3_2 - 0.0033 17.2 18.1 3.2 7.9 0.6 7.3 8 0 0 8 8 8 2 Leucine Rich repeat LIM PF00412.20 NM_001083919.1_1 - 2e-08 34.2 9.9 5e-08 32.9 9.9 1.7 1 0 0 1 1 1 1 LIM domain Xin PF08043.10 NM_001083919.1_3 - 2.5e-169 544.6 80.2 8.8e-09 34.6 0.2 30.1 30 0 0 30 30 30 27 Xin repeat CagD PF16567.3 NM_001083919.1_3 - 0.048 13.3 0.1 0.19 11.4 0.0 2.0 2 0 0 2 2 2 0 Pathogenicity island component CagD Bacteroid_pep PF14406.4 NM_001083919.1_3 - 0.52 10.6 4.7 6.2 7.1 0.1 5.4 5 0 0 5 5 5 0 Ribosomally synthesized peptide in Bacteroidetes Ras PF00071.20 NM_001310589.1_3 - 1.2e-38 132.1 0.1 1.6e-38 131.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001310589.1_3 - 2.5e-26 92.1 0.1 3.7e-26 91.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001310589.1_3 - 3.7e-12 45.9 0.0 5e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_001310589.1_3 - 3e-05 23.4 0.1 4e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.18 NM_001310589.1_3 - 0.02 14.0 0.7 0.13 11.3 0.2 2.0 1 1 1 2 2 2 0 G-protein alpha subunit PduV-EutP PF10662.7 NM_001310589.1_3 - 0.05 13.2 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Pkinase PF00069.23 NM_001039139.2_1 - 4.4e-74 249.0 0.0 6.3e-74 248.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CaMKII_AD PF08332.8 NM_001039139.2_1 - 1.6e-59 199.5 0.0 2.6e-59 198.8 0.0 1.3 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.15 NM_001039139.2_1 - 5.7e-34 117.4 0.0 9.8e-34 116.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase SnoaL_3 PF13474.4 NM_001039139.2_1 - 2e-10 40.8 0.0 3.5e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.4 NM_001039139.2_1 - 2.3e-09 37.5 0.0 4.5e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Kdo PF06293.12 NM_001039139.2_1 - 0.018 14.3 0.2 0.035 13.3 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001039139.2_1 - 0.019 14.7 0.1 2.5 7.8 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family SnoaL_2 PF12680.5 NM_001039139.2_1 - 0.085 13.4 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain DcpS_C PF11969.6 NM_027030.2_2 - 5.5e-32 110.5 0.0 1e-31 109.6 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.10 NM_027030.2_2 - 6.4e-20 71.8 0.0 1.1e-19 71.0 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal F-box_4 PF15966.3 NM_027968.3_2 - 8.8e-49 164.1 0.8 1.6e-48 163.3 0.3 1.7 2 0 0 2 2 2 1 F-box zf-TRAF_2 PF15965.3 NM_027968.3_2 - 2.3e-38 130.4 16.5 2.3e-38 130.4 16.5 2.8 4 0 0 4 4 4 1 TRAF-like zinc-finger F-box PF00646.31 NM_027968.3_2 - 3.4e-06 26.6 0.2 1.4e-05 24.7 0.2 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 NM_027968.3_2 - 4.8e-05 23.0 0.5 0.00021 20.9 0.1 2.3 2 0 0 2 2 2 1 F-box-like DUF4644 PF15486.4 NM_027968.3_2 - 0.1 12.2 0.4 10 5.7 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4644) zf-TRAF PF02176.16 NM_027968.3_2 - 2.9 8.5 15.9 0.023 15.3 2.8 4.1 5 0 0 5 5 5 0 TRAF-type zinc finger Syja_N PF02383.16 NM_001113353.2_1 - 2.4e-65 220.8 0.0 3.3e-65 220.3 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain DUF1866 PF08952.9 NM_001113353.2_1 - 1.1e-59 200.3 0.1 1.8e-59 199.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.21 NM_001113353.2_1 - 2.6e-07 30.8 0.0 6.2e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Takusan PF04822.11 NM_182957.1_1 - 1.6e-28 98.3 8.2 1.6e-28 98.3 8.2 1.9 2 0 0 2 2 2 1 Takusan DUF3473 PF11959.6 NM_182957.1_1 - 0.037 13.9 0.2 0.064 13.1 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3473) PilJ PF13675.4 NM_182957.1_1 - 0.053 13.4 2.6 1 9.3 0.8 2.5 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term APG6 PF04111.10 NM_182957.1_1 - 5.6 6.1 21.6 12 5.0 20.8 1.9 1 1 0 1 1 1 0 Autophagy protein Apg6 zf-H2C2_2 PF13465.4 NM_001039532.2_2 - 2.3e-20 71.9 38.0 2.7e-07 30.6 0.4 7.1 7 0 0 7 7 7 3 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001039532.2_2 - 3.3e-14 52.3 50.4 3.1e-05 24.0 4.1 6.7 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001039532.2_2 - 2.7e-11 43.2 43.1 0.01 16.5 2.7 7.2 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001039532.2_2 - 1.1e-05 25.5 18.8 0.00012 22.2 1.8 5.2 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001039532.2_2 - 0.017 15.4 4.0 0.017 15.4 4.0 6.4 7 0 0 7 7 7 0 Zinc-finger of C2H2 type zf-BED PF02892.13 NM_001039532.2_2 - 7.9 6.5 9.5 6 6.9 1.5 3.7 1 1 2 3 3 3 0 BED zinc finger Filament PF00038.19 NM_008473.2_3 - 1.5e-102 343.3 36.1 1.7e-102 343.0 36.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 NM_008473.2_3 - 6.4e-33 114.1 83.3 6.4e-33 114.1 83.3 3.7 2 2 1 3 3 1 1 Keratin type II head Keratin_2_tail PF16210.3 NM_008473.2_3 - 3.7e-25 88.6 113.9 3.7e-25 88.6 113.9 3.7 2 1 1 3 3 1 1 Keratin type II cytoskeletal 1 tail TPR_MLP1_2 PF07926.10 NM_008473.2_3 - 2.8e-07 30.5 30.3 4.3e-05 23.4 5.1 3.5 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein Alanine_zipper PF11839.6 NM_008473.2_3 - 0.00079 19.5 1.0 0.00079 19.5 1.0 2.8 2 1 1 3 3 3 1 Alanine-zipper, major outer membrane lipoprotein DUF342 PF03961.11 NM_008473.2_3 - 0.0013 17.3 5.9 0.0013 17.3 5.9 2.2 1 1 0 2 2 2 1 Protein of unknown function (DUF342) Spc7 PF08317.9 NM_008473.2_3 - 0.0017 17.2 35.9 0.0082 14.9 4.1 4.0 1 1 3 4 4 4 3 Spc7 kinetochore protein She9_MDM33 PF05546.9 NM_008473.2_3 - 0.0074 16.0 13.6 0.44 10.2 5.0 2.7 2 1 0 2 2 2 2 She9 / Mdm33 family T3SSipB PF16535.3 NM_008473.2_3 - 0.011 16.0 10.5 0.13 12.6 1.9 2.6 2 0 0 2 2 2 0 Type III cell invasion protein SipB SAT PF16073.3 NM_008473.2_3 - 0.015 14.8 0.8 0.039 13.4 0.4 1.9 1 1 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis SesA PF17107.3 NM_008473.2_3 - 0.021 14.9 1.6 0.021 14.9 1.6 2.1 2 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF948 PF06103.9 NM_008473.2_3 - 0.039 14.1 0.6 0.039 14.1 0.6 3.7 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.4 NM_008473.2_3 - 0.046 12.9 20.2 0.061 12.5 6.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF812 PF05667.9 NM_008473.2_3 - 0.055 12.2 32.3 0.12 11.1 12.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Tropomyosin_1 PF12718.5 NM_008473.2_3 - 0.081 12.9 30.0 0.062 13.3 9.5 3.1 2 1 1 3 3 3 0 Tropomyosin like Reo_sigmaC PF04582.10 NM_008473.2_3 - 0.19 10.9 11.9 0.19 11.0 1.2 2.6 1 1 2 3 3 3 0 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.7 NM_008473.2_3 - 0.2 11.5 31.5 0.78 9.6 10.6 3.5 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.10 NM_008473.2_3 - 0.22 11.4 21.5 0.16 11.8 1.2 3.9 2 2 0 3 3 3 0 Protein of unknown function (DUF1664) TRAF_BIRC3_bd PF16673.3 NM_008473.2_3 - 0.26 11.0 9.4 1.5 8.5 0.1 3.5 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain YscO PF07321.10 NM_008473.2_3 - 0.27 11.0 17.0 0.12 12.2 5.6 2.6 2 1 0 2 2 2 0 Type III secretion protein YscO LPP PF04728.11 NM_008473.2_3 - 0.3 11.4 17.2 0.64 10.3 0.6 4.6 4 1 1 5 5 5 0 Lipoprotein leucine-zipper DUF3538 PF12057.6 NM_008473.2_3 - 0.37 10.4 4.6 0.5 9.9 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3538) Golgin_A5 PF09787.7 NM_008473.2_3 - 0.66 9.3 34.1 0.022 14.1 10.6 2.9 1 1 3 4 4 4 0 Golgin subfamily A member 5 Taxilin PF09728.7 NM_008473.2_3 - 0.72 8.9 31.4 8.7 5.4 31.2 2.4 1 1 0 1 1 1 0 Myosin-like coiled-coil protein Bcr-Abl_Oligo PF09036.8 NM_008473.2_3 - 0.74 9.7 5.3 6.9 6.6 0.4 2.9 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain DUF745 PF05335.11 NM_008473.2_3 - 0.85 9.2 18.1 1 8.9 6.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF745) CHDCT2 PF08074.9 NM_008473.2_3 - 0.87 9.6 15.7 2.2 8.3 2.9 2.7 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain ANAPC4 PF12896.5 NM_008473.2_3 - 0.95 8.8 11.1 1.4 8.3 0.4 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 4 FPP PF05911.9 NM_008473.2_3 - 1.1 7.3 31.8 0.2 9.7 13.5 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil GAS PF13851.4 NM_008473.2_3 - 1.8 7.8 35.3 0.011 15.0 3.4 3.7 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding Jnk-SapK_ap_N PF09744.7 NM_008473.2_3 - 2 8.5 30.8 0.92 9.6 6.5 3.2 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 FliJ PF02050.14 NM_008473.2_3 - 3.3 7.8 27.6 0.66 10.1 3.9 3.7 2 2 1 3 3 3 0 Flagellar FliJ protein UPF0184 PF03670.11 NM_008473.2_3 - 3.6 7.9 9.2 7.1 7.0 0.1 3.2 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) ATG16 PF08614.9 NM_008473.2_3 - 3.7 7.5 27.4 0.82 9.7 1.3 3.2 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) IncA PF04156.12 NM_008473.2_3 - 4.3 6.9 36.1 1.4 8.5 11.4 3.1 1 1 2 3 3 3 0 IncA protein Baculo_PEP_C PF04513.10 NM_008473.2_3 - 4.5 7.2 20.0 0.16 11.9 1.6 3.5 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HrpB7 PF09486.8 NM_008473.2_3 - 4.9 7.4 13.7 0.18 12.0 0.7 3.1 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) JIP_LZII PF16471.3 NM_008473.2_3 - 7 6.8 20.8 8.1 6.6 0.7 5.3 4 2 1 5 5 5 0 JNK-interacting protein leucine zipper II DUF1451 PF07295.9 NM_008473.2_3 - 7.5 6.5 13.3 3.8 7.4 1.5 2.8 2 1 1 3 3 3 0 Zinc-ribbon containing domain ABC_tran_CTD PF16326.3 NM_008473.2_3 - 7.7 6.7 15.8 0.1 12.7 5.1 3.1 2 1 1 3 3 3 0 ABC transporter C-terminal domain FlaC_arch PF05377.9 NM_008473.2_3 - 8.6 6.7 21.5 0.54 10.5 0.5 4.9 3 2 3 6 6 5 0 Flagella accessory protein C (FlaC) PACT_coil_coil PF10495.7 NM_008787.3_1 - 2e-24 85.8 0.1 2e-24 85.8 0.1 9.9 11 3 0 12 12 12 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Ribosomal_L22 PF00237.17 NM_175001.3_3 - 1.2e-27 96.2 0.5 1.6e-27 95.8 0.2 1.4 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e RRM_1 PF00076.20 NM_001080127.1_3 - 1.1e-17 63.4 0.0 1.7e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 NM_001080127.1_3 - 0.0012 18.7 0.0 0.0026 17.7 0.0 1.5 1 0 0 1 1 1 1 Limkain b1 RRM_7 PF16367.3 NM_001080127.1_3 - 0.0013 18.7 0.0 0.0025 17.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.4 NM_001080127.1_3 - 0.01 15.6 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 NM_001080127.1_3 - 0.012 15.1 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 NM_001080127.1_3 - 0.012 15.5 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 RNA binding motif Macoilin PF09726.7 NM_001080127.1_3 - 0.016 13.7 25.6 0.021 13.2 25.6 1.1 1 0 0 1 1 1 0 Transmembrane protein RRM_occluded PF16842.3 NM_001080127.1_3 - 0.032 13.9 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif LAP1C PF05609.10 NM_001080127.1_3 - 0.31 9.9 18.2 0.45 9.4 18.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Collagen PF01391.16 NM_172787.2_1 - 0.00037 20.1 23.9 0.00037 20.1 23.9 1.8 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) MBT PF02820.16 NM_172787.2_2 - 1.5e-92 303.8 4.1 1.5e-29 102.0 0.0 3.5 3 0 0 3 3 3 3 mbt repeat SAM_1 PF00536.28 NM_172787.2_2 - 1.7e-14 53.9 0.0 2.9e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_172787.2_2 - 9.6e-06 25.5 0.0 1.7e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C2HC PF01530.16 NM_172787.2_2 - 4.6e-05 23.4 4.1 0.00016 21.7 4.1 2.0 1 0 0 1 1 1 1 Zinc finger, C2HC type Glyco_hydro_2_N PF02837.16 NM_172787.2_2 - 0.0066 16.2 0.0 0.17 11.6 0.0 2.6 2 1 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain SOG2 PF10428.7 NM_172787.2_2 - 0.36 9.9 26.2 0.51 9.4 26.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein SPATA3 PF15662.3 NM_001122732.1_3 - 4.5e-92 307.8 28.7 6.1e-92 307.4 28.7 1.2 1 0 0 1 1 1 1 Spermatogenesis-associated protein 3 family GPS2_interact PF15784.3 NM_001252313.1_2 - 1.7e-34 118.2 7.4 1.7e-34 118.2 7.4 5.3 4 0 0 4 4 4 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 NM_001252313.1_2 - 5.9e-18 64.6 0.2 4.2e-12 45.9 0.2 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 NM_001252313.1_2 - 0.0031 17.6 1.8 0.064 13.4 0.3 2.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain MARVEL PF01284.21 NM_024217.3_3 - 1.7e-09 37.7 15.7 3.3e-09 36.8 15.7 1.5 1 0 0 1 1 1 1 Membrane-associating domain HMG_box PF00505.17 NM_011440.1_1 - 2.9e-28 97.9 5.0 5.6e-28 97.0 5.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_011440.1_1 - 9.5e-12 45.2 2.8 1.7e-11 44.4 2.8 1.4 1 0 0 1 1 1 1 HMG-box domain SOXp PF12336.6 NM_011440.1_1 - 2.9e-06 28.1 0.3 2.1e-05 25.3 0.3 2.2 1 1 0 1 1 1 1 SOX transcription factor Trypsin PF00089.24 NM_001164698.1_1 - 1.3e-72 244.1 0.4 1.6e-72 243.8 0.4 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_001164698.1_1 - 4e-10 40.0 0.0 7.3e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_001164698.1_1 - 7.7e-06 26.7 0.0 1.4e-05 25.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain 7tm_4 PF13853.4 NM_146949.1_1 - 1.1e-54 185.9 25.2 1.3e-54 185.7 25.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146949.1_1 - 6.6e-24 84.4 26.2 2.2e-23 82.7 26.2 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Plectin PF00681.18 NM_011117.2_1 - 1.4e-297 959.2 37.1 5e-21 74.2 0.0 29.8 26 5 6 32 32 32 26 Plectin repeat CH PF00307.29 NM_011117.2_1 - 2.3e-47 159.5 0.2 1.7e-22 79.6 0.2 3.3 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_011117.2_1 - 3e-05 23.7 0.1 0.016 14.9 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain Imm70 PF15601.4 NM_011117.2_1 - 0.72 9.3 3.7 0.89 9.0 0.0 3.2 3 0 0 3 3 3 0 Immunity protein 70 Spore_YhaL PF14147.4 NM_011117.2_1 - 7.1 6.3 8.2 70 3.1 8.2 2.9 1 0 0 1 1 1 0 Sporulation protein YhaL C2-set_2 PF08205.10 NM_001166027.1_1 - 0.0014 18.5 0.1 0.0026 17.7 0.1 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain DUF3810 PF12725.5 NM_001166027.1_1 - 2.1 7.5 6.0 1 8.5 3.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) 7tm_4 PF13853.4 NM_146764.1_1 - 4.6e-55 187.2 21.5 5.3e-55 187.0 21.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146764.1_1 - 1.9e-18 66.6 22.9 3.4e-18 65.7 22.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_146764.1_1 - 0.91 9.0 5.3 0.68 9.4 0.9 2.8 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus zf-C2H2_assoc3 PF16637.3 NM_001253691.1_1 - 2e-28 98.4 5.4 3.9e-28 97.5 5.4 1.5 1 0 0 1 1 1 1 Putative zinc-finger between two C2H2 zinc-fingers on Patz zf-C2H2 PF00096.24 NM_001253691.1_1 - 0.00021 21.5 0.8 0.00021 21.5 0.8 5.5 6 0 0 6 6 6 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001253691.1_1 - 0.0073 16.9 0.8 0.0073 16.9 0.8 6.0 6 0 0 6 6 6 2 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001253691.1_1 - 0.023 14.5 0.2 0.023 14.5 0.2 4.8 5 0 0 5 5 5 0 C2H2-type zinc finger ARS2 PF04959.11 NM_001253691.1_1 - 0.2 11.9 0.7 0.31 11.3 0.0 1.6 2 0 0 2 2 2 0 Arsenite-resistance protein 2 zf-C2H2_11 PF16622.3 NM_001253691.1_1 - 6.3 6.5 9.1 0.94 9.2 0.1 2.9 2 0 0 2 2 2 0 zinc-finger C2H2-type BTB PF00651.29 NM_001253691.1_2 - 1.6e-25 89.4 0.0 2.4e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 NM_001253691.1_2 - 2.3e-14 52.7 27.0 0.0015 19.0 0.3 5.3 5 0 0 5 5 4 4 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001253691.1_2 - 3.4e-14 52.3 23.9 0.00067 19.8 0.4 5.3 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001253691.1_2 - 1.9e-11 43.7 21.3 9.2e-06 25.7 2.3 5.5 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_jaz PF12171.6 NM_001253691.1_2 - 3.8e-07 30.1 8.0 0.73 10.1 0.4 4.9 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001253691.1_2 - 7.1e-07 29.3 7.2 1.5 9.2 0.0 4.8 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 NM_001253691.1_2 - 0.00033 20.4 14.3 0.0098 15.7 0.3 4.6 4 0 0 4 4 4 1 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001253691.1_2 - 0.012 15.6 7.4 0.14 12.2 0.5 3.7 3 0 0 3 3 3 0 Zinc ribbon domain zf-Di19 PF05605.10 NM_001253691.1_2 - 0.027 14.6 5.7 0.12 12.5 0.4 3.4 2 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.13 NM_001253691.1_2 - 1.6 8.7 8.3 23 5.0 0.2 3.9 4 0 0 4 4 4 0 BED zinc finger zf-C2H2_2 PF12756.5 NM_001253691.1_2 - 5.1 7.3 7.1 1.3e+02 2.9 0.1 4.0 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) SP_C-Propep PF08999.8 NM_011359.2_3 - 5.3e-49 163.8 2.0 7.1e-49 163.4 2.0 1.2 1 0 0 1 1 1 1 Surfactant protein C, N terminal propeptide BRICHOS PF04089.12 NM_011359.2_3 - 9.4e-22 76.8 0.0 1.4e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain DUF945 PF06097.9 NM_011359.2_3 - 0.22 10.4 0.7 0.32 9.9 0.7 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) DRMBL PF07522.12 NM_001110214.1_1 - 7.1e-20 71.2 0.2 1.2e-19 70.5 0.2 1.4 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.5 NM_001110214.1_1 - 2.9e-06 26.8 0.0 4.8e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.25 NM_001110214.1_1 - 0.023 14.6 0.1 1.7 8.5 0.0 2.3 3 0 0 3 3 3 0 Metallo-beta-lactamase superfamily Autophagy_act_C PF03987.13 NM_025770.3_1 - 2.6e-18 66.2 0.6 5e-18 65.3 0.6 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Guanylate_kin PF00625.19 NM_001243046.1_2 - 4.5e-65 218.6 0.1 6.5e-65 218.1 0.1 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 NM_001243046.1_2 - 7.9e-20 70.9 0.6 1.2e-19 70.3 0.6 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_2 PF07653.15 NM_001243046.1_2 - 2e-08 33.7 0.0 4.2e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001243046.1_2 - 3.5e-08 32.8 0.0 6.8e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain PDZ_2 PF13180.4 NM_001243046.1_2 - 0.00016 21.8 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.4 NM_001243046.1_2 - 0.0066 16.2 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain TTL PF03133.13 NM_001014974.1_2 - 7.2e-104 346.9 0.2 7.2e-104 346.9 0.2 1.7 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 NM_001014974.1_2 - 6.7e-05 22.1 0.0 0.0022 17.2 0.0 2.7 2 0 0 2 2 2 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 NM_001014974.1_2 - 0.0068 15.6 0.0 0.046 12.8 0.0 2.0 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp SR-25 PF10500.7 NM_001014974.1_3 - 0.29 10.6 26.6 0.44 10.0 26.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4604 PF15377.4 NM_001014974.1_3 - 0.87 9.9 17.8 1.2 9.4 17.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) OB_NTP_bind PF07717.14 NM_026987.2_3 - 4.3e-22 78.2 0.0 1.2e-21 76.8 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 NM_026987.2_3 - 2.2e-20 72.8 0.0 2.2e-20 72.8 0.0 3.0 2 1 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 NM_026987.2_3 - 5.2e-12 46.0 0.0 1.3e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 NM_026987.2_3 - 4.1e-07 29.8 0.0 1.2e-06 28.3 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_30 PF13604.4 NM_026987.2_3 - 2.6e-05 23.9 0.0 7.5e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 NM_026987.2_3 - 0.0014 18.7 0.0 0.0055 16.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.4 NM_026987.2_3 - 0.0098 16.1 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.18 NM_026987.2_3 - 0.012 14.6 0.0 0.042 12.8 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein SecA_DEAD PF07517.12 NM_026987.2_3 - 0.02 14.1 0.1 0.058 12.5 0.0 1.7 2 0 0 2 2 2 0 SecA DEAD-like domain Flavi_DEAD PF07652.12 NM_026987.2_3 - 0.031 14.1 0.0 0.07 13.0 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain SRP54 PF00448.20 NM_026987.2_3 - 0.062 12.8 0.1 0.2 11.1 0.1 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ResIII PF04851.13 NM_026987.2_3 - 0.12 12.2 0.4 5 6.9 0.0 3.0 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_23 PF13476.4 NM_026987.2_3 - 1.8 8.9 0.0 1.8 8.9 0.0 2.6 2 0 0 2 2 1 0 AAA domain MMR_HSR1_Xtn PF16897.3 NM_007879.1_2 - 3.1e-45 152.4 0.3 5.1e-45 151.7 0.3 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.19 NM_007879.1_2 - 7e-25 86.7 0.0 1.4e-24 85.7 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.21 NM_007879.1_2 - 1.6e-19 69.9 0.0 3.6e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 NM_007879.1_2 - 2.2e-10 40.2 0.1 1.9e-09 37.1 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B ArgK PF03308.14 NM_007879.1_2 - 0.0063 15.4 0.2 0.032 13.1 0.0 1.9 2 0 0 2 2 2 1 ArgK protein Dynamin_N PF00350.21 NM_007879.1_2 - 0.0094 15.9 0.4 3.5 7.5 0.2 2.3 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.25 NM_007879.1_2 - 0.022 14.2 0.1 6.1 6.2 0.0 3.5 2 2 1 3 3 3 0 Elongation factor Tu GTP binding domain 7tm_4 PF13853.4 NM_146684.1_1 - 2e-51 175.3 15.9 2.6e-51 174.9 15.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146684.1_1 - 1.1e-20 73.9 15.5 2.1e-20 72.9 15.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) WD40 PF00400.30 NM_001286466.1_3 - 4.6e-34 115.7 23.7 8.6e-06 26.3 0.2 8.1 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.5 NM_001286466.1_3 - 8.3e-10 38.3 0.1 1.9e-09 37.1 0.1 1.7 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.5 NM_001286466.1_3 - 4.7e-07 29.9 1.5 0.14 12.3 0.2 3.9 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.31 NM_001286466.1_3 - 3.8e-06 26.5 0.1 9e-06 25.3 0.1 1.6 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.3 NM_001286466.1_3 - 0.0003 20.1 0.2 0.049 12.8 0.2 2.1 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.6 NM_001286466.1_3 - 0.0098 14.4 6.3 0.57 8.6 0.1 3.6 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Arm PF00514.21 NM_008466.5_1 - 4.2e-84 274.2 16.4 2.5e-12 46.2 0.3 9.1 8 1 1 9 9 9 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.3 NM_008466.5_1 - 3.6e-23 80.7 2.5 8.4e-22 76.3 3.2 2.2 2 0 0 2 2 2 1 Atypical Arm repeat IBB PF01749.18 NM_008466.5_1 - 1.5e-22 79.6 4.4 2.7e-22 78.8 4.4 1.4 1 0 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.4 NM_008466.5_1 - 1.1e-20 73.5 8.6 2.6e-08 34.0 0.3 6.8 6 1 1 7 7 7 5 HEAT-like repeat HEAT PF02985.20 NM_008466.5_1 - 1.4e-15 55.9 5.7 0.0074 16.3 0.0 6.3 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.4 NM_008466.5_1 - 2.6e-15 56.5 0.3 3e-06 27.4 0.0 5.2 2 2 2 5 5 5 3 HEAT repeats Atx10homo_assoc PF09759.7 NM_008466.5_1 - 0.00033 20.5 0.8 2 8.4 0.0 4.4 2 1 3 5 5 5 1 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.5 NM_008466.5_1 - 0.00053 19.9 0.4 0.96 9.3 0.0 3.1 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.6 NM_008466.5_1 - 0.0026 17.8 0.9 7.5 6.6 0.1 3.9 4 0 0 4 4 4 1 V-ATPase subunit H Arm_2 PF04826.11 NM_008466.5_1 - 0.0026 17.1 0.9 20 4.4 0.0 3.8 2 1 2 4 4 4 0 Armadillo-like CCDC106 PF15794.3 NM_201361.2_2 - 0.022 14.4 1.1 0.042 13.4 1.1 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Spore_III_AB PF09548.8 NM_201361.2_2 - 0.05 13.6 1.5 0.13 12.3 0.7 2.2 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) HMG_box_2 PF09011.8 NM_008253.4_1 - 6.4e-48 161.1 10.2 1.8e-29 102.0 7.2 2.4 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.17 NM_008253.4_1 - 2.1e-44 149.6 9.6 4e-27 94.3 0.1 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_5 PF14887.4 NM_008253.4_1 - 0.0003 20.6 8.5 0.035 14.0 0.3 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box 5 Ribosomal_60s PF00428.17 NM_008253.4_1 - 1 9.8 18.3 2.3 8.7 18.3 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein YABBY PF04690.11 NM_008253.4_1 - 3 8.3 5.2 2.3 8.6 0.8 2.3 1 1 2 3 3 3 0 YABBY protein Xan_ur_permease PF00860.18 NM_011397.4_1 - 1.6e-87 293.7 25.7 2e-87 293.3 25.7 1.1 1 0 0 1 1 1 1 Permease family RRM_7 PF16367.3 NM_001290828.1_2 - 3.9e-35 119.7 0.0 6.9e-34 115.7 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.3 NM_001290828.1_2 - 1.3e-19 70.0 5.9 1.3e-19 70.0 5.9 2.3 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.20 NM_001290828.1_2 - 1.2e-10 41.0 0.0 4.4e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 PF06220.10 NM_001290828.1_2 - 0.099 12.3 0.6 0.25 11.0 0.6 1.6 1 0 0 1 1 1 0 U1 zinc finger DUF4644 PF15486.4 NM_028484.2_3 - 1.3e-89 297.9 9.9 2.2e-89 297.2 9.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4644) RhoGEF PF00621.18 NM_019867.2_2 - 4.5e-35 121.4 6.4 9.9e-35 120.3 6.4 1.6 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 NM_019867.2_2 - 6.9e-12 44.7 0.0 1.5e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_019867.2_2 - 7.1e-12 44.9 0.0 1.4e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_019867.2_2 - 4.6e-07 29.3 0.0 9e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 NM_019867.2_2 - 1.1e-05 25.8 0.0 2.9e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 PH domain SesA PF17107.3 NM_019867.2_2 - 0.12 12.4 0.2 0.32 11.1 0.2 1.6 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Cor1 PF04803.10 NM_027510.2_3 - 3.5e-37 127.4 22.9 3.5e-37 127.4 22.9 1.6 2 0 0 2 2 2 1 Cor1/Xlr/Xmr conserved region Mgr1 PF08602.8 NM_027510.2_3 - 0.03 13.0 5.9 0.042 12.5 5.9 1.2 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Exonuc_VII_L PF02601.13 NM_027510.2_3 - 0.2 11.0 5.5 0.26 10.7 5.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Amidoligase_2 PF12224.6 NM_027510.2_3 - 0.25 10.8 4.2 0.11 12.0 1.8 1.7 2 0 0 2 2 2 0 Putative amidoligase enzyme DUF4168 PF13767.4 NM_027510.2_3 - 0.92 10.6 9.5 0.75 10.9 6.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4168) Cu_amine_oxid PF01179.18 NM_001161621.1_3 - 2.1e-120 402.2 0.0 2.9e-120 401.8 0.0 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.14 NM_001161621.1_3 - 1.9e-27 95.1 0.0 3.8e-27 94.2 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.14 NM_001161621.1_3 - 9.1e-21 74.0 0.0 2.2e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain DUF1965 PF09248.8 NM_001161621.1_3 - 1.8e-06 27.5 0.0 4.7e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) HOOK PF05622.10 NM_001081291.1_1 - 5.1e-13 48.0 21.9 5.1e-13 48.0 21.9 5.8 3 2 1 5 5 5 1 HOOK protein TMF_TATA_bd PF12325.6 NM_001081291.1_1 - 0.0024 18.0 15.2 0.0024 18.0 15.2 11.6 4 3 7 12 12 12 2 TATA element modulatory factor 1 TATA binding Pkinase_Tyr PF07714.15 NM_009184.2_1 - 1.4e-90 303.0 0.0 1.8e-90 302.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_009184.2_1 - 6.6e-48 163.2 0.0 9.6e-48 162.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 NM_009184.2_1 - 4.6e-18 64.9 0.1 8.9e-18 64.0 0.1 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 NM_009184.2_1 - 1.9e-08 33.6 0.2 4.8e-08 32.3 0.2 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_009184.2_1 - 4.6e-08 32.7 0.1 1.2e-07 31.3 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_009184.2_1 - 4.2e-07 29.4 0.0 9.3e-07 28.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain CTF_NFI PF00859.16 NM_001297601.1_3 - 9.5e-71 239.0 20.9 2.7e-47 162.0 2.5 2.9 2 1 1 3 3 3 2 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.7 NM_001297601.1_3 - 3.3e-26 90.8 4.4 7.1e-26 89.7 4.4 1.6 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.14 NM_001297601.1_3 - 4.4e-10 39.6 0.1 7.4e-10 38.8 0.1 1.4 1 0 0 1 1 1 1 MH1 domain PMP22_Claudin PF00822.18 NM_001302257.1_2 - 9e-47 158.9 17.8 1.4e-46 158.3 17.8 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001302257.1_2 - 1.3e-07 31.4 12.6 1.3e-07 31.4 12.6 2.6 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction L_HMGIC_fpl PF10242.7 NM_001302257.1_2 - 0.0019 18.3 10.8 0.0035 17.4 10.8 1.5 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DUF973 PF06157.9 NM_001302257.1_2 - 9 5.1 8.3 14 4.5 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF973) Serpin PF00079.18 NM_201376.1_1 - 7.7e-129 430.1 17.2 8.7e-129 429.9 17.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PH PF00169.27 NM_201376.1_1 - 0.042 14.2 2.5 17 5.8 0.1 3.2 3 0 0 3 3 3 0 PH domain zf-C2H2 PF00096.24 NM_175099.3_2 - 5.8e-64 209.0 109.5 1.2e-07 31.6 0.3 15.6 15 0 0 15 15 15 15 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_175099.3_2 - 2.7e-58 191.8 89.1 5.1e-09 36.0 0.7 15.4 17 0 0 17 17 15 9 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_175099.3_2 - 6.7e-36 119.7 111.2 0.0013 19.3 0.4 15.5 15 0 0 15 15 15 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_175099.3_2 - 2e-17 62.5 81.2 0.01 15.6 0.1 15.4 15 0 0 15 15 15 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_175099.3_2 - 1.3e-10 41.0 56.5 0.027 14.4 2.7 9.8 9 2 0 9 9 9 5 Zinc ribbon domain ADK_lid PF05191.12 NM_175099.3_2 - 2.9e-06 27.0 20.9 0.68 9.9 0.0 8.7 5 5 1 7 7 7 1 Adenylate kinase, active site lid zf-C2H2_8 PF15909.3 NM_175099.3_2 - 0.00065 19.8 47.2 0.11 12.7 1.9 8.5 3 3 5 8 8 8 3 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.6 NM_175099.3_2 - 0.0024 18.0 39.4 0.34 11.2 0.1 11.4 13 0 0 13 13 13 2 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_175099.3_2 - 0.0079 16.4 15.7 1.3 9.2 0.2 5.6 5 1 1 6 6 6 1 zinc-finger-containing domain zf-LYAR PF08790.9 NM_175099.3_2 - 0.022 14.5 44.5 5.5 6.9 0.1 13.0 15 0 0 15 15 15 0 LYAR-type C2HC zinc finger zf-met PF12874.5 NM_175099.3_2 - 0.025 14.8 0.0 0.025 14.8 0.0 13.4 15 0 0 15 15 15 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_175099.3_2 - 0.031 13.9 0.1 0.031 13.9 0.1 11.9 13 0 0 13 13 13 0 zinc-finger C2H2-type GAGA PF09237.9 NM_175099.3_2 - 0.072 12.8 16.2 0.2 11.3 1.2 5.3 3 2 2 5 5 5 0 GAGA factor zf-C2HC_2 PF13913.4 NM_175099.3_2 - 0.14 11.9 0.1 0.14 11.9 0.1 11.2 14 0 0 14 14 10 0 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.3 NM_175099.3_2 - 0.23 12.1 36.5 3.2 8.4 1.4 7.7 2 2 8 10 10 10 0 zinc-ribbon family DZR PF12773.5 NM_175099.3_2 - 0.26 11.2 64.0 4.6e+02 0.8 3.5 8.8 2 2 1 3 3 2 0 Double zinc ribbon FYDLN_acid PF09538.8 NM_175099.3_2 - 3.6 8.2 43.0 11 6.7 0.2 10.5 7 2 4 12 12 10 0 Protein of unknown function (FYDLN_acid) HypA PF01155.17 NM_175099.3_2 - 5.6 6.9 42.8 2.2 8.2 2.3 7.9 2 2 3 5 5 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CpXC PF14353.4 NM_175099.3_2 - 6.2 6.7 46.0 31 4.5 1.1 11.8 7 4 1 9 9 9 0 CpXC protein TPR_2 PF07719.15 NM_053081.2_1 - 1.3e-09 37.3 7.3 0.0076 16.2 0.0 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.26 NM_053081.2_1 - 1.8e-06 27.3 0.0 0.00075 19.1 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.4 NM_053081.2_1 - 9.8e-05 22.4 12.8 0.0058 16.8 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_053081.2_1 - 0.022 14.8 6.1 1.6 9.0 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.4 NM_053081.2_1 - 0.084 12.8 6.7 0.73 9.9 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.4 NM_053081.2_1 - 0.17 12.1 1.8 4.5 7.5 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.4 NM_053081.2_1 - 0.27 11.7 6.2 23 5.4 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_053081.2_1 - 0.32 10.8 0.0 0.32 10.8 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat COX4 PF02936.12 NM_001293559.1_1 - 4.9e-59 198.1 1.4 6.5e-59 197.8 1.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV 7tm_4 PF13853.4 NM_001011820.1_1 - 7.8e-55 186.4 13.9 1e-54 186.0 13.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011820.1_1 - 1.8e-30 105.9 16.2 3.2e-30 105.1 16.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011820.1_1 - 0.00074 18.8 17.7 0.0011 18.3 17.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF3512 PF12024.6 NM_001308041.1_3 - 4.6e-82 274.9 0.0 4.6e-82 274.9 0.0 2.0 2 0 0 2 2 1 1 Domain of unknown function (DUF3512) Bromodomain PF00439.23 NM_001308041.1_3 - 5e-24 84.0 0.1 6e-23 80.6 0.1 2.4 2 0 0 2 2 2 1 Bromodomain NPR3 PF03666.11 NM_001308041.1_3 - 0.12 11.0 2.7 0.24 10.0 2.7 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SR-25 PF10500.7 NM_001308041.1_3 - 0.78 9.2 22.1 0.067 12.7 16.7 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein U79_P34 PF03064.14 NM_001308041.1_3 - 0.81 8.9 18.7 1.4 8.1 18.7 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF1510 PF07423.9 NM_001308041.1_3 - 1.5 8.1 11.0 2.7 7.2 11.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Coilin_N PF15862.3 NM_001308041.1_3 - 1.6 8.4 15.1 3.9 7.1 15.1 1.6 1 0 0 1 1 1 0 Coilin N-terminus RR_TM4-6 PF06459.10 NM_001308041.1_3 - 2 8.0 10.4 3.8 7.1 10.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.12 NM_001308041.1_3 - 3.6 5.6 12.0 5.2 5.1 12.0 1.1 1 0 0 1 1 1 0 CDC45-like protein NARP1 PF12569.6 NM_001308041.1_3 - 8.5 5.0 14.6 15 4.2 14.6 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Presenilin PF01080.15 NM_001308041.1_3 - 9.4 4.7 6.6 14 4.1 6.6 1.2 1 0 0 1 1 1 0 Presenilin OATP PF03137.18 NM_175316.3_3 - 1.1e-192 641.0 9.4 1.4e-192 640.7 9.4 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 NM_175316.3_3 - 1.5e-15 56.9 17.9 1.5e-15 56.9 17.9 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.13 NM_175316.3_3 - 0.51 10.4 8.3 1.2 9.3 8.3 1.7 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Ets PF00178.20 NM_008026.5_2 - 2.4e-35 120.7 0.3 5.1e-35 119.7 0.3 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 NM_008026.5_2 - 9.4e-28 95.9 0.1 2.2e-27 94.7 0.1 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Acylphosphatase PF00708.16 NM_029344.3_3 - 4.6e-23 81.3 0.0 6.2e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 Acylphosphatase COesterase PF00135.26 NM_133660.3_1 - 4.4e-167 556.9 0.0 5.1e-167 556.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 NM_133660.3_1 - 6.4e-11 42.4 2.7 6.2e-10 39.2 1.2 2.7 1 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_133660.3_1 - 0.0041 16.5 0.1 0.0076 15.6 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.7 NM_133660.3_1 - 0.021 13.5 0.0 0.047 12.4 0.0 1.4 1 1 0 1 1 1 0 Steryl acetyl hydrolase Esterase PF00756.18 NM_133660.3_1 - 0.061 12.8 0.4 0.19 11.2 0.4 1.7 1 1 0 1 1 1 0 Putative esterase UPF0121 PF03661.11 NM_028975.4_1 - 2.4e-95 318.3 12.7 5.3e-95 317.2 12.7 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Filamin PF00630.17 NM_001081185.1_1 - 0 1322.1 38.6 2.7e-19 69.7 0.0 24.2 24 0 0 24 24 24 24 Filamin/ABP280 repeat CH PF00307.29 NM_001081185.1_1 - 3.8e-39 133.1 0.4 3.6e-20 72.0 0.2 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain Y_Y_Y PF07495.11 NM_001081185.1_1 - 3.2e-21 74.9 12.8 1.3 8.9 0.0 14.4 16 0 0 16 16 16 5 Y_Y_Y domain Big_3_5 PF16640.3 NM_001081185.1_1 - 1.8e-17 63.1 42.7 0.014 15.4 0.1 15.3 18 1 0 18 18 18 5 Bacterial Ig-like domain (group 3) DUF5060 PF16586.3 NM_001081185.1_1 - 2.9e-15 56.2 1.8 3.7 7.8 0.0 14.5 18 0 0 18 18 18 1 Domain of unknown function (DUF5060) YtkA PF13115.4 NM_001081185.1_1 - 6.1e-14 52.3 18.0 0.41 11.2 0.1 14.1 17 0 0 17 17 15 3 YtkA-like EMP24_GP25L PF01105.22 NM_001081185.1_1 - 2.2e-05 24.3 3.6 14 5.4 0.0 8.6 10 0 0 10 10 10 0 emp24/gp25L/p24 family/GOLD Invasin_D3 PF09134.8 NM_001081185.1_1 - 0.00031 20.3 9.0 21 4.8 0.0 8.1 8 0 0 8 8 8 0 Invasin, domain 3 CAMSAP_CH PF11971.6 NM_001081185.1_1 - 0.0015 18.2 0.0 1.5 8.6 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain PapC_N PF13954.4 NM_001081185.1_1 - 0.0075 16.1 0.0 4.9 7.0 0.0 5.5 6 0 0 6 6 6 1 PapC N-terminal domain CH_2 PF06294.9 NM_001081185.1_1 - 0.011 15.7 0.1 2.6 8.1 0.0 2.3 2 0 0 2 2 2 0 CH-like domain in sperm protein SH2 PF00017.22 NM_001081185.1_1 - 0.014 15.3 0.0 4.6 7.2 0.0 4.6 3 0 0 3 3 3 0 SH2 domain DUF4369 PF14289.4 NM_001081185.1_1 - 0.036 14.6 0.1 4.6 7.8 0.0 4.6 5 0 0 5 5 3 0 Domain of unknown function (DUF4369) CBM_35 PF16990.3 NM_001081185.1_1 - 0.22 11.6 1.2 8.8 6.5 0.0 4.4 5 0 0 5 5 5 0 Carbohydrate binding module (family 35) Big_3 PF07523.10 NM_001081185.1_1 - 5.3 7.3 34.7 14 5.9 0.5 12.2 11 4 4 15 15 14 0 Bacterial Ig-like domain (group 3) Aldo_ket_red PF00248.19 NM_134066.2_1 - 9.1e-52 175.9 0.0 1.1e-51 175.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Mtf2_C PF14061.4 NM_028716.4_1 - 1.5e-26 92.2 0.0 2.7e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 PHD PF00628.27 NM_028716.4_1 - 6.4e-11 41.8 19.6 9.7e-07 28.5 4.2 2.7 2 0 0 2 2 2 2 PHD-finger Prok-RING_1 PF14446.4 NM_028716.4_1 - 0.012 15.4 2.5 0.012 15.4 2.5 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 DUF4537 PF15057.4 NM_028716.4_1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) LBR_tudor PF09465.8 NM_028716.4_1 - 0.19 11.4 0.2 0.46 10.2 0.2 1.6 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain ADK_lid PF05191.12 NM_028716.4_1 - 0.25 11.3 1.9 11 6.0 0.3 2.9 2 0 0 2 2 2 0 Adenylate kinase, active site lid C1_1 PF00130.20 NM_028716.4_1 - 6 6.7 22.7 0.036 13.8 1.0 3.4 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.4 NM_028716.4_1 - 9.9 5.7 20.3 0.93 8.9 6.6 3.5 2 2 0 2 2 2 0 PHD-finger ART PF01129.16 NM_026639.2_1 - 3.2e-47 160.5 0.0 5.7e-47 159.7 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Ras PF00071.20 NM_019566.3_2 - 1e-56 190.9 0.0 1.3e-56 190.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_019566.3_2 - 1.6e-21 76.6 0.0 2.2e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_019566.3_2 - 2.2e-08 33.6 0.0 3e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_019566.3_2 - 0.11 11.6 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Anti-TRAP PF15777.3 NM_019566.3_3 - 0.021 14.6 0.4 0.045 13.6 0.4 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-C2H2 PF00096.24 NM_007963.2_1 - 7e-40 133.2 57.1 7e-07 29.2 1.4 8.7 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_007963.2_1 - 3.4e-30 103.0 55.8 4.7e-08 33.0 1.2 9.9 10 0 0 10 10 10 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_007963.2_1 - 4e-27 92.4 51.7 0.001 19.6 0.7 9.2 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_007963.2_1 - 1.4e-12 47.4 42.2 0.003 17.7 0.8 8.7 8 0 0 8 8 8 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_007963.2_1 - 1.1e-11 44.2 44.1 6.7e-05 22.6 0.1 8.2 8 0 0 8 8 8 5 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_007963.2_1 - 2.5e-09 36.6 47.0 5.8e-05 22.6 2.4 7.7 7 1 0 7 7 7 5 C2H2-type zinc-finger domain zf-BED PF02892.13 NM_007963.2_1 - 0.00023 21.0 34.5 0.00089 19.1 0.7 5.8 3 2 3 6 6 6 3 BED zinc finger zf-C2H2_11 PF16622.3 NM_007963.2_1 - 0.0016 18.0 35.0 0.067 12.8 0.8 7.4 8 0 0 8 8 8 3 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 NM_007963.2_1 - 0.012 15.6 1.6 0.012 15.6 1.6 6.6 6 1 0 6 6 6 0 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_007963.2_1 - 0.019 15.6 24.8 0.41 11.3 0.6 5.6 3 2 2 5 5 5 0 zinc-ribbon family PyrI_C PF02748.13 NM_007963.2_1 - 0.13 12.0 21.4 0.45 10.3 0.0 5.5 5 1 1 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain GAGA PF09237.9 NM_007963.2_1 - 0.3 10.8 14.2 3.3 7.4 0.1 4.7 2 1 2 4 4 4 0 GAGA factor BolA PF01722.16 NM_007963.2_1 - 0.31 11.2 2.1 26 5.1 0.1 3.9 3 2 0 3 3 3 0 BolA-like protein zf-C2H2_8 PF15909.3 NM_007963.2_1 - 1.3 9.2 24.4 0.49 10.6 1.1 4.3 2 1 2 4 4 4 0 C2H2-type zinc ribbon zf-met PF12874.5 NM_007963.2_1 - 2 8.8 47.3 0.47 10.8 0.3 8.0 8 0 0 8 8 7 0 Zinc-finger of C2H2 type S6OS1 PF15676.3 NM_029444.2_1 - 1.6e-272 904.9 51.5 1.8e-272 904.7 51.5 1.0 1 0 0 1 1 1 1 Six6 opposite strand transcript 1 family KIX_2 PF16987.3 NM_029444.2_1 - 2.9 7.8 10.0 5.3 7.0 5.9 3.1 2 1 0 2 2 2 0 KIX domain CDC45 PF02724.12 NM_001161623.1_3 - 8.5e-136 453.7 13.6 2.9e-116 389.1 8.5 3.0 1 1 1 2 2 2 2 CDC45-like protein V1R PF03402.12 NM_001166718.1_1 - 2.6e-18 66.5 12.8 3.6e-18 66.0 12.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R DUF4501 PF14946.4 NM_001166718.1_1 - 0.048 13.6 1.7 0.15 12.0 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4501) FA_desaturase PF00487.22 NM_021890.3_2 - 3.8e-32 112.0 25.1 3.8e-32 112.0 25.1 2.5 2 1 1 3 3 3 2 Fatty acid desaturase Cyt-b5 PF00173.26 NM_021890.3_2 - 2.4e-18 65.9 0.0 5e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Kelch_1 PF01344.23 NM_178633.3_3 - 1.6e-84 277.2 22.1 1.3e-15 56.6 0.1 6.6 6 0 0 6 6 6 6 Kelch motif BACK PF07707.13 NM_178633.3_3 - 1.6e-35 121.1 1.3 3e-35 120.3 0.9 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.4 NM_178633.3_3 - 3.6e-35 119.0 2.7 2.2e-06 27.6 0.0 6.6 4 2 2 6 6 6 6 Kelch motif BTB PF00651.29 NM_178633.3_3 - 3.4e-31 107.6 0.1 6e-31 106.8 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.4 NM_178633.3_3 - 8.5e-29 99.1 14.7 2.7e-05 24.2 0.1 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_178633.3_3 - 5.3e-25 86.3 6.8 1e-05 25.2 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.4 NM_178633.3_3 - 2e-23 82.0 5.2 0.0016 18.2 0.1 6.4 4 1 2 6 6 6 6 Galactose oxidase, central domain PQQ_3 PF13570.4 NM_178633.3_3 - 0.21 12.0 12.2 19 5.8 0.0 4.9 5 0 0 5 5 5 0 PQQ-like domain Kelch_5 PF13854.4 NM_178633.3_3 - 6.5 6.7 14.9 22 5.0 0.3 5.0 5 0 0 5 5 5 0 Kelch motif MscS_porin PF12795.5 NM_027159.2_2 - 0.021 14.2 0.6 5.6 6.3 0.1 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain OAD_gamma PF04277.11 NM_144925.3_1 - 0.35 11.4 1.3 0.91 10.0 1.3 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TNRC6-PABC_bdg PF16608.3 NM_144925.3_3 - 7.3e-123 409.8 31.9 7.3e-123 409.8 31.9 7.6 7 2 2 9 9 9 1 TNRC6-PABC binding domain Ago_hook PF10427.7 NM_144925.3_3 - 3.5e-19 69.8 20.1 3.5e-19 69.8 20.1 9.9 4 1 1 7 7 7 1 Argonaute hook RRM_1 PF00076.20 NM_144925.3_3 - 0.0023 17.6 0.0 0.005 16.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fis1_TPR_C PF14853.4 NM_025744.2_3 - 0.015 15.3 0.1 0.028 14.4 0.1 1.4 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat OTU PF02338.17 NM_027715.1_1 - 1.4e-24 86.8 0.0 2.5e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Phage_FRD3 PF05798.9 NM_198619.2_1 - 0.067 13.3 7.4 9 6.5 0.1 4.7 4 1 1 5 5 5 0 Bacteriophage FRD3 protein zf-H2C2_2 PF13465.4 NM_198619.2_3 - 5e-103 333.2 106.0 2.2e-09 37.2 1.8 16.7 15 1 1 16 16 16 16 Zinc-finger double domain zf-C2H2 PF00096.24 NM_198619.2_3 - 2.4e-58 191.3 106.8 5e-06 26.6 2.2 15.1 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_198619.2_3 - 1.9e-36 121.4 94.8 0.0012 19.3 1.4 15.4 15 0 0 15 15 14 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_198619.2_3 - 3.3e-28 96.9 80.4 0.0043 16.8 2.6 14.5 13 0 0 13 13 13 13 C2H2-type zinc finger KRAB PF01352.25 NM_198619.2_3 - 1.4e-20 72.6 0.1 2.3e-20 71.9 0.1 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_198619.2_3 - 1.9e-05 24.5 70.6 0.11 12.5 2.3 10.1 4 2 10 14 14 14 9 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_198619.2_3 - 0.0037 17.8 60.1 0.34 11.6 2.1 7.4 4 2 1 7 7 7 5 zinc-ribbon family DUF3268 PF11672.6 NM_198619.2_3 - 0.029 14.6 47.9 0.28 11.4 1.1 7.3 2 2 7 10 10 10 0 zinc-finger-containing domain XPA_N PF01286.16 NM_198619.2_3 - 0.056 13.4 51.4 11 6.0 0.1 13.1 13 0 0 13 13 13 0 XPA protein N-terminal zinc_ribbon_9 PF14369.4 NM_198619.2_3 - 0.93 9.7 37.9 17 5.6 0.0 11.5 13 0 0 13 13 13 0 zinc-ribbon CpXC PF14353.4 NM_198619.2_3 - 1.3 9.0 49.1 32 4.4 0.1 11.7 8 2 2 12 12 12 0 CpXC protein zf-C2H2_11 PF16622.3 NM_198619.2_3 - 2.1 8.0 54.8 0.47 10.1 0.5 11.5 12 0 0 12 12 12 0 zinc-finger C2H2-type 7tm_4 PF13853.4 NM_001005569.1_1 - 1.4e-61 208.5 20.3 1.7e-61 208.2 20.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005569.1_1 - 2e-25 89.4 26.9 1.1e-24 87.0 26.9 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001005569.1_1 - 0.00021 20.6 22.1 0.00048 19.5 22.1 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Abi PF02517.14 NM_023131.1_1 - 8.6e-16 58.0 3.7 2.1e-15 56.8 3.7 1.6 1 0 0 1 1 1 1 CAAX protease self-immunity FUSC-like PF12805.5 NM_023131.1_1 - 0.39 9.6 1.9 0.85 8.5 1.9 1.5 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS Arylesterase PF01731.18 NM_011134.3_3 - 4.8e-39 132.3 0.4 9.3e-39 131.4 0.4 1.5 1 0 0 1 1 1 1 Arylesterase SGL PF08450.10 NM_011134.3_3 - 5.9e-11 42.3 0.0 1.3e-10 41.1 0.0 1.5 1 1 1 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.14 NM_011134.3_3 - 0.00057 19.8 0.0 0.0015 18.4 0.0 1.7 1 0 0 1 1 1 1 Strictosidine synthase WD40 PF00400.30 NM_028759.1_3 - 3.9e-17 62.2 9.6 0.013 16.2 0.1 7.8 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_028759.1_3 - 1.8e-08 34.4 0.0 0.029 14.5 0.0 4.3 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_028759.1_3 - 0.051 12.8 0.1 0.084 12.1 0.1 1.3 1 0 0 1 1 1 0 WD40-like domain TAS2R PF05296.11 NM_207020.1_1 - 1.2e-82 277.3 41.7 1.4e-82 277.1 41.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF809 PF05663.9 NM_207020.1_1 - 0.027 14.5 0.4 0.027 14.5 0.4 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF809) PEX11 PF05648.12 NM_011069.3_1 - 1.1e-72 244.0 0.0 1.4e-72 243.6 0.0 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Glyco_transf_29 PF00777.16 NM_145838.1_2 - 7.8e-76 254.9 0.1 1e-75 254.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) CREPT PF16566.3 NM_145838.1_2 - 0.055 13.5 0.1 0.093 12.8 0.1 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Pkinase PF00069.23 NM_145621.2_1 - 1.4e-61 208.1 0.1 1.7e-61 207.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_145621.2_1 - 3.2e-22 78.9 0.0 4.4e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_145621.2_1 - 0.00011 21.5 0.0 0.0069 15.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.12 NM_145621.2_1 - 0.12 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ig_2 PF13895.4 NM_008816.3_2 - 1.7e-37 127.5 7.8 6.6e-13 48.7 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin domain Ig_3 PF13927.4 NM_008816.3_2 - 1.5e-30 105.5 6.7 2.1e-07 31.3 0.2 6.6 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 NM_008816.3_2 - 1.8e-12 47.1 15.1 5.1e-05 23.2 0.3 7.1 6 1 0 6 6 6 3 Immunoglobulin domain I-set PF07679.14 NM_008816.3_2 - 2.4e-11 43.4 13.0 0.0015 18.4 0.2 6.5 5 2 0 5 5 5 3 Immunoglobulin I-set domain Izumo-Ig PF16706.3 NM_008816.3_2 - 7.4e-05 22.6 8.0 0.15 12.0 0.6 4.3 5 0 0 5 5 4 2 Izumo-like Immunoglobulin domain MAP17 PF15807.3 NM_008816.3_2 - 0.0039 17.3 0.7 0.013 15.6 0.3 1.9 1 1 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Shisa PF13908.4 NM_008816.3_2 - 0.031 14.4 0.1 0.077 13.1 0.1 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Ig_4 PF16680.3 NM_008816.3_2 - 0.055 13.7 8.9 5.6 7.3 0.0 4.9 6 0 0 6 6 6 0 T-cell surface glycoprotein CD3 delta chain EVC2_like PF12297.6 NM_008816.3_2 - 0.13 10.8 0.0 0.22 10.0 0.0 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein FixG_C PF11614.6 NM_008816.3_2 - 0.14 12.2 0.5 0.95 9.6 0.4 2.5 3 1 0 3 3 2 0 IG-like fold at C-terminal of FixG, putative oxidoreductase C2-set_2 PF08205.10 NM_008816.3_2 - 3.4 7.7 7.2 7.7 6.5 0.1 4.2 5 0 0 5 5 5 0 CD80-like C2-set immunoglobulin domain PsbL PF02419.15 NM_008816.3_2 - 8.4 6.3 7.0 3.7 7.5 3.0 2.6 2 0 0 2 2 2 0 PsbL protein Myb_DNA-binding PF00249.29 NM_001177601.1_3 - 0.0007 19.6 0.1 0.0012 18.8 0.1 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 NM_001177601.1_3 - 0.00086 19.0 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.4 NM_001177601.1_3 - 0.038 14.1 0.0 0.062 13.4 0.0 1.3 1 0 0 1 1 1 0 Myb-like DNA-binding domain SOXp PF12336.6 NM_009237.2_1 - 1.4e-30 106.1 0.1 1.4e-30 106.1 0.1 2.5 2 0 0 2 2 2 1 SOX transcription factor HMG_box PF00505.17 NM_009237.2_1 - 1.8e-26 92.2 1.5 2.9e-26 91.5 1.5 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_009237.2_1 - 1.8e-09 37.9 1.0 2.9e-09 37.3 1.0 1.3 1 0 0 1 1 1 1 HMG-box domain adh_short_C2 PF13561.4 NM_023523.5_3 - 7e-52 176.2 0.0 9.3e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 NM_023523.5_3 - 5.8e-45 153.0 0.9 7.9e-45 152.6 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 NM_023523.5_3 - 2.1e-08 34.1 0.0 3.5e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.17 NM_023523.5_3 - 0.0012 18.1 0.0 0.0019 17.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.16 NM_023523.5_3 - 0.0059 16.7 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.15 NM_023523.5_3 - 0.027 14.9 0.0 0.075 13.5 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Macoilin PF09726.7 NM_001113405.1_1 - 0.37 9.2 13.1 0.48 8.8 13.1 1.0 1 0 0 1 1 1 0 Transmembrane protein SR-25 PF10500.7 NM_001113405.1_1 - 2.6 7.5 16.1 4.1 6.8 16.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.10 NM_001113405.1_1 - 7.5 6.1 11.4 13 5.3 11.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PDEase_I PF00233.17 NM_001310750.1_3 - 4.7e-94 314.4 2.9 7.7e-94 313.7 2.9 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase NadA PF02445.14 NM_001310750.1_3 - 0.13 11.3 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Quinolinate synthetase A protein 7tm_4 PF13853.4 NM_146414.1_1 - 2.5e-55 188.1 19.2 2.9e-55 187.8 19.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146414.1_1 - 6.6e-18 64.8 22.0 6.6e-18 64.8 22.0 1.7 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 NM_001167537.1_1 - 7.3e-29 101.1 16.9 9.6e-29 100.7 16.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001167537.1_1 - 1.8e-12 46.9 26.6 2.1e-12 46.6 26.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001167537.1_1 - 0.0045 16.1 16.9 0.0071 15.5 16.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) YdjM PF04307.12 NM_001167537.1_1 - 0.024 13.8 1.9 0.13 11.4 1.7 2.4 1 1 1 2 2 2 0 LexA-binding, inner membrane-associated putative hydrolase 7tm_4 PF13853.4 NM_020515.1_1 - 6.1e-47 160.5 18.9 7.1e-47 160.3 18.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_020515.1_1 - 5.3e-19 68.4 23.2 1.3e-18 67.1 23.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cu2_monoox_C PF03712.13 NM_138942.3_1 - 2e-64 215.7 0.7 3.6e-64 214.9 0.7 1.4 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.18 NM_138942.3_1 - 2.7e-46 156.9 0.0 4.9e-46 156.1 0.0 1.4 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain DOMON PF03351.15 NM_138942.3_1 - 2.3e-29 102.0 0.0 4.3e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 DOMON domain EF-hand_1 PF00036.30 NM_145399.1_2 - 4.5e-22 75.8 7.0 6.8e-06 25.1 0.0 5.6 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.4 NM_145399.1_2 - 7.3e-19 65.9 10.0 0.00021 20.8 0.1 5.7 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.4 NM_145399.1_2 - 3.6e-17 62.4 8.2 6.9e-09 35.9 0.6 3.7 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 NM_145399.1_2 - 5.2e-12 44.6 0.1 0.02 14.3 0.2 3.8 3 0 0 3 3 3 3 EF hand GPHH PF16905.3 NM_145399.1_2 - 3.9e-06 26.4 0.1 0.0071 16.0 0.0 2.8 2 0 0 2 2 2 2 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_10 PF14788.4 NM_145399.1_2 - 5.9e-06 25.9 4.8 0.09 12.5 0.0 5.0 4 1 1 5 5 5 1 EF hand EF-hand_8 PF13833.4 NM_145399.1_2 - 0.0006 19.4 6.9 0.017 14.8 0.3 4.3 4 1 1 5 5 5 1 EF-hand domain pair Caleosin PF05042.11 NM_145399.1_2 - 0.0086 15.9 1.6 1.9 8.2 0.0 3.7 2 2 1 4 4 4 1 Caleosin related protein SPARC_Ca_bdg PF10591.7 NM_145399.1_2 - 0.012 15.8 6.7 0.45 10.7 0.1 3.9 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DUF543 PF04418.10 NM_001163006.2_3 - 8.7e-23 80.0 0.6 1.5e-22 79.2 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF543) Ribonuc_red_lgC PF02867.13 NM_009103.3_1 - 5e-192 639.0 0.0 6.5e-192 638.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.19 NM_009103.3_1 - 5.1e-23 80.8 0.0 1.1e-22 79.6 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.14 NM_009103.3_1 - 3.4e-18 65.9 0.0 8.1e-18 64.6 0.0 1.7 1 0 0 1 1 1 1 ATP cone domain SPRY PF00622.26 NM_001177551.1_3 - 3.3e-15 56.1 0.0 7e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_001177551.1_3 - 8e-13 47.7 0.0 1.9e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_4 PF15227.4 NM_001177551.1_3 - 5.8e-12 45.4 8.7 1.5e-11 44.1 8.7 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 NM_001177551.1_3 - 3.8e-08 32.9 6.9 1.1e-07 31.5 6.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001177551.1_3 - 2.3e-05 24.0 7.2 5.5e-05 22.8 7.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001177551.1_3 - 6.2e-05 22.8 5.7 6.2e-05 22.8 5.7 2.0 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_001177551.1_3 - 0.0018 18.0 9.2 0.0046 16.7 9.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001177551.1_3 - 0.026 14.4 7.0 0.076 12.9 7.0 1.9 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.4 NM_001177551.1_3 - 0.058 13.5 8.2 0.15 12.2 8.2 1.7 1 0 0 1 1 1 0 Ring finger domain zf-RING_4 PF14570.4 NM_001177551.1_3 - 0.28 10.8 4.1 0.24 11.0 1.3 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.4 NM_001177551.1_3 - 1.4 8.7 4.7 2.8 7.7 4.7 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 NM_001177551.1_3 - 2.2 8.4 10.0 1.2 9.2 7.1 2.1 2 0 0 2 2 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 NM_001177551.1_3 - 8.1 6.3 13.6 1.6 8.5 9.9 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 RNase_PH PF01138.19 NM_138586.3_3 - 1.5e-22 80.4 0.1 2.9e-22 79.5 0.1 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 NM_138586.3_3 - 1.4e-07 31.3 0.0 2.2e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Fez1 PF06818.13 NM_001109684.1_3 - 0.00024 21.5 15.7 0.0031 17.8 10.0 2.3 2 0 0 2 2 2 2 Fez1 DUF148 PF02520.15 NM_001109684.1_3 - 0.027 14.4 5.5 0.059 13.3 5.5 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF148 Baculo_PEP_C PF04513.10 NM_001109684.1_3 - 7.2 6.5 6.6 6.5 6.7 0.4 2.9 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fumble PF03630.12 NM_001305804.1_3 - 4.6e-131 436.8 0.2 5.9e-131 436.4 0.2 1.1 1 0 0 1 1 1 1 Fumble DUF89 PF01937.17 NM_001305804.1_3 - 9.2e-61 205.7 0.0 1.3e-60 205.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF89 HAP1_N PF04849.11 NM_001310526.1_1 - 0.00098 18.3 4.1 0.00098 18.3 4.1 4.7 2 1 2 4 4 4 2 HAP1 N-terminal conserved region Fez1 PF06818.13 NM_001310526.1_1 - 0.0034 17.7 2.8 0.0034 17.7 2.8 4.6 2 1 2 4 4 4 1 Fez1 DUF4200 PF13863.4 NM_001310526.1_1 - 0.0065 16.7 13.6 0.0065 16.7 13.6 7.1 4 2 3 7 7 7 1 Domain of unknown function (DUF4200) Cytochrom_C_2 PF01322.18 NM_001310526.1_1 - 1.8 9.3 13.5 0.71 10.7 2.4 3.2 3 0 0 3 3 3 0 Cytochrome C' Kinesin PF00225.21 NM_008440.4_1 - 3.8e-116 387.5 1.4 5.3e-116 387.0 1.4 1.2 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.3 NM_008440.4_1 - 8.5e-85 283.3 2.3 3.8e-82 274.7 2.3 2.7 1 1 0 1 1 1 1 Kinesin-associated DUF3694 PF12473.6 NM_008440.4_1 - 9.4e-37 126.9 0.0 1.9e-36 125.9 0.0 1.6 1 0 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.3 NM_008440.4_1 - 3.9e-25 88.4 0.5 1e-24 87.1 0.5 1.7 1 0 0 1 1 1 1 Microtubule binding PH PF00169.27 NM_008440.4_1 - 2.2e-12 47.3 0.0 1.3e-11 44.8 0.0 2.4 2 0 0 2 2 2 1 PH domain KIF1B PF12423.6 NM_008440.4_1 - 1.4e-11 44.6 0.0 1.4e-11 44.6 0.0 2.5 2 0 0 2 2 2 1 Kinesin protein 1B FHA PF00498.24 NM_008440.4_1 - 5.2e-07 29.8 0.2 1.9e-06 28.0 0.0 2.1 2 0 0 2 2 2 1 FHA domain PH_11 PF15413.4 NM_008440.4_1 - 0.14 12.5 0.1 0.53 10.6 0.1 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain Pkinase_Tyr PF07714.15 NM_001025395.2_1 - 4.7e-92 307.8 0.0 6e-92 307.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001025395.2_1 - 2.8e-45 154.6 0.0 3.9e-45 154.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 NM_001025395.2_1 - 4.4e-27 93.8 0.2 7.7e-27 93.1 0.2 1.4 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 NM_001025395.2_1 - 3.6e-17 61.6 0.1 1.4e-16 59.6 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 NM_001025395.2_1 - 4.7e-14 51.8 0.0 1.4e-13 50.4 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001025395.2_1 - 8.3e-09 34.9 0.0 1.8e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 NM_001025395.2_1 - 0.071 13.3 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain hSH3 PF14603.4 NM_001025395.2_1 - 0.19 12.2 0.0 0.36 11.3 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain ApoO PF09769.7 NM_001199338.1_3 - 7e-39 132.6 0.0 1.1e-38 132.0 0.0 1.3 1 0 0 1 1 1 1 Apolipoprotein O COX4 PF02936.12 NM_053091.2_2 - 3e-50 169.7 2.7 3.9e-50 169.3 2.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF566 PF04484.10 NM_010262.3_1 - 0.39 10.3 3.4 0.93 9.1 3.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF566) Homeobox PF00046.27 NM_010262.3_2 - 1.9e-23 81.9 6.0 3.8e-23 80.9 6.0 1.5 1 0 0 1 1 1 1 Homeobox domain CEP170_C PF15308.4 NM_010262.3_2 - 1.7 6.9 6.2 2.1 6.6 4.8 1.7 1 1 1 2 2 2 0 CEP170 C-terminus Metallophos PF00149.26 NM_019411.4_1 - 7.1e-34 118.0 0.5 1.1e-33 117.4 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 NM_019411.4_1 - 0.0096 16.2 0.3 0.02 15.1 0.3 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain YqzH PF14164.4 NM_019411.4_1 - 0.17 11.8 3.6 0.22 11.5 2.3 1.8 2 0 0 2 2 2 0 YqzH-like protein 7tm_4 PF13853.4 NM_001011798.1_1 - 2.2e-50 171.8 24.9 2.8e-50 171.5 24.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011798.1_1 - 7.9e-24 84.2 25.1 1.5e-23 83.3 25.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011798.1_1 - 8.2e-06 25.2 21.2 1e-05 25.0 21.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Pkinase PF00069.23 NM_001013833.3_2 - 5e-70 235.7 0.0 9.1e-70 234.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.27 NM_001013833.3_2 - 1.7e-38 130.4 0.1 5.2e-19 67.9 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.15 NM_001013833.3_2 - 9.7e-35 120.0 0.0 1.8e-34 119.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PKcGMP_CC PF16808.3 NM_001013833.3_2 - 2.3e-14 52.8 16.9 4.7e-14 51.8 16.9 1.6 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Kinase-like PF14531.4 NM_001013833.3_2 - 0.00043 19.6 0.0 0.00065 19.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 NM_001013833.3_2 - 0.0073 16.9 0.5 0.015 15.8 0.5 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Wtap PF17098.3 NM_001013833.3_2 - 0.019 14.8 0.6 0.031 14.1 0.6 1.2 1 0 0 1 1 1 0 WTAP/Mum2p family IncA PF04156.12 NM_001013833.3_2 - 0.13 11.9 1.3 0.23 11.1 1.3 1.4 1 0 0 1 1 1 0 IncA protein DUF641 PF04859.10 NM_001013833.3_2 - 0.14 12.3 1.8 0.36 11.0 1.8 1.6 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) OmpH PF03938.12 NM_001013833.3_2 - 0.84 9.5 2.6 1.6 8.6 2.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Asp-B-Hydro_N PF05279.9 NM_001177854.1_3 - 1.5e-70 237.9 30.7 2e-45 155.6 14.8 2.2 1 1 1 2 2 2 2 Aspartyl beta-hydroxylase N-terminal region ATG27 PF09451.8 NM_001177854.1_3 - 0.02 14.6 0.2 0.033 13.9 0.2 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 DUF2897 PF11446.6 NM_001177854.1_3 - 2.6 7.9 9.7 5 7.0 9.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) Kelch_1 PF01344.23 NM_145479.4_3 - 1.1e-41 140.0 9.3 5.7e-11 41.7 0.1 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.4 NM_145479.4_3 - 1.5e-37 126.5 4.0 4e-07 29.9 0.0 5.7 5 1 1 6 6 6 5 Kelch motif BTB PF00651.29 NM_145479.4_3 - 1.3e-27 96.1 1.8 3.3e-25 88.4 0.3 2.4 1 1 1 2 2 2 2 BTB/POZ domain Kelch_3 PF13415.4 NM_145479.4_3 - 9.9e-24 83.0 3.2 1.9e-09 37.5 0.1 5.3 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_145479.4_3 - 9e-22 76.0 6.0 6.3e-06 25.8 0.0 5.9 5 1 0 5 5 5 4 Kelch motif BACK PF07707.13 NM_145479.4_3 - 1.1e-15 57.5 0.5 2.2e-15 56.5 0.5 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_4 PF13418.4 NM_145479.4_3 - 6e-15 54.8 1.2 0.0044 16.8 0.0 5.5 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_145479.4_3 - 2.7e-06 27.1 3.7 1.6 8.6 0.0 5.3 6 0 0 6 6 6 2 Kelch motif RRM_1 PF00076.20 NM_139065.3_1 - 6.7e-36 121.8 0.2 5.1e-14 51.7 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_139065.3_1 - 0.00057 19.8 0.1 0.29 11.2 0.0 3.4 3 0 0 3 3 3 1 RNA recognition motif RRM_5 PF13893.4 NM_139065.3_1 - 0.0007 19.1 0.0 0.078 12.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET PF00856.26 NM_001035123.3_1 - 2.2e-20 73.6 0.0 4.4e-20 72.6 0.0 1.5 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.9 NM_001035123.3_1 - 6e-15 56.0 0.8 1.2e-14 55.0 0.8 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding 7tm_4 PF13853.4 NM_146829.2_2 - 1e-48 166.4 25.6 1.3e-48 166.0 25.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146829.2_2 - 3.9e-20 72.1 26.8 7.1e-20 71.2 26.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DJ-1_PfpI PF01965.22 NM_172116.4_1 - 0.011 15.4 0.0 0.041 13.5 0.0 1.8 1 1 0 1 1 1 0 DJ-1/PfpI family Acyl_transf_3 PF01757.20 NM_177028.3_3 - 4.4e-21 75.2 36.6 6.7e-21 74.6 36.6 1.2 1 0 0 1 1 1 1 Acyltransferase family IL8 PF00048.18 NM_008176.3_1 - 1.4e-14 53.8 0.3 2.8e-14 52.9 0.3 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Defensin_beta_2 PF13841.4 NM_008176.3_1 - 0.21 11.9 3.6 0.6 10.5 3.6 1.8 1 0 0 1 1 1 0 Beta defensin DUF1664 PF07889.10 NM_001165253.1_3 - 0.0013 18.5 0.3 0.0013 18.5 0.3 4.4 3 1 1 4 4 4 2 Protein of unknown function (DUF1664) NPIP PF06409.9 NM_001165253.1_3 - 0.38 9.8 6.7 0.84 8.7 6.7 1.5 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) HrpB7 PF09486.8 NM_001165253.1_3 - 0.45 10.7 32.6 0.97 9.7 1.8 3.9 2 2 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) Reo_sigmaC PF04582.10 NM_001165253.1_3 - 0.7 9.1 16.5 0.74 9.0 2.3 2.5 2 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF3584 PF12128.6 NM_001165253.1_3 - 2.4 5.4 58.5 6.7 4.0 58.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Trypsin_2 PF13365.4 NM_001272092.1_1 - 4.3e-10 40.5 5.9 4.5e-06 27.5 0.4 2.7 3 0 0 3 3 3 2 Trypsin-like peptidase domain Trypsin PF00089.24 NM_001272092.1_1 - 0.059 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Trypsin Keratin_B2_2 PF13885.4 NM_027568.2_3 - 1.9e-10 40.4 166.3 1.5e-06 27.9 57.2 4.4 2 1 1 4 4 4 3 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_027568.2_3 - 1.2 8.9 125.7 4.8 7.0 36.9 3.3 1 1 2 3 3 3 0 Keratin, high sulfur B2 protein C1q PF00386.19 NM_001204152.1_2 - 1.3e-30 106.1 0.0 1.8e-30 105.6 0.0 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 NM_001204152.1_3 - 5.3 6.7 8.0 0.36 10.5 1.9 2.1 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) Mg_chelatase PF01078.19 NM_007860.4_1 - 0.089 12.0 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI T4_deiodinase PF00837.15 NM_007860.4_3 - 9.9e-96 319.5 0.1 1.3e-95 319.1 0.1 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase Zip PF02535.20 NM_001290765.1_2 - 3.6e-51 174.2 4.8 2e-48 165.2 4.8 2.1 1 1 0 1 1 1 1 ZIP Zinc transporter 7tm_4 PF13853.4 NM_146927.1_1 - 1.6e-45 155.9 21.2 2.1e-45 155.5 21.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146927.1_1 - 9.6e-24 83.9 23.0 2.5e-23 82.6 23.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146927.1_1 - 3.2e-06 26.6 24.1 4.1e-06 26.2 24.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CHDCT2 PF08074.9 NM_145979.2_1 - 1.2e-87 292.3 0.4 2.9e-87 291.1 0.4 1.7 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF1086 PF06461.9 NM_145979.2_1 - 5.2e-61 204.4 0.0 1.5e-60 202.9 0.0 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.21 NM_145979.2_1 - 2.9e-59 200.4 0.1 7.2e-59 199.1 0.0 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain DUF1087 PF06465.11 NM_145979.2_1 - 3e-26 91.1 6.0 3e-26 91.1 6.0 2.9 3 0 0 3 3 2 1 Domain of Unknown Function (DUF1087) CHDNT PF08073.10 NM_145979.2_1 - 7e-26 89.8 0.1 1.8e-25 88.5 0.1 1.8 1 0 0 1 1 1 1 CHDNT (NUC034) domain Helicase_C PF00271.29 NM_145979.2_1 - 1.3e-22 80.1 0.0 2.7e-22 79.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 NM_145979.2_1 - 2.7e-21 75.0 27.9 2e-10 40.3 8.8 2.6 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.22 NM_145979.2_1 - 1.8e-18 66.0 5.6 3.4e-12 45.9 0.9 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 NM_145979.2_1 - 2.8e-10 40.3 0.9 1.5e-09 37.9 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 NM_145979.2_1 - 5.6e-07 28.9 0.0 1.5e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 PHD_2 PF13831.4 NM_145979.2_1 - 0.003 16.9 11.7 0.086 12.3 2.8 2.6 2 0 0 2 2 2 2 PHD-finger HMG_box PF00505.17 NM_145979.2_1 - 0.0056 16.9 0.1 0.021 15.1 0.1 2.0 1 0 0 1 1 1 1 HMG (high mobility group) box DEAD PF00270.27 NM_145979.2_1 - 0.039 13.6 0.0 0.22 11.1 0.0 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase C2 PF00168.28 NM_009025.2_3 - 2e-35 121.1 0.0 1.1e-18 67.3 0.0 3.0 2 1 0 2 2 2 2 C2 domain RasGAP PF00616.17 NM_009025.2_3 - 1.6e-33 116.1 0.2 8.9e-20 71.1 0.1 2.3 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase BTK PF00779.17 NM_009025.2_3 - 2.9e-13 49.2 4.5 7e-13 48.0 4.5 1.7 1 0 0 1 1 1 1 BTK motif PH PF00169.27 NM_009025.2_3 - 1.3e-12 48.0 0.3 1.3e-12 48.0 0.3 2.0 2 0 0 2 2 2 1 PH domain Filament PF00038.19 NM_001003668.2_2 - 2.1e-94 316.5 30.0 2.4e-94 316.3 30.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 NM_001003668.2_2 - 1.8e-10 41.1 8.3 1.8e-10 41.1 8.3 2.7 2 1 0 2 2 2 1 Keratin type II head TPR_MLP1_2 PF07926.10 NM_001003668.2_2 - 7.4e-06 25.9 28.8 6.6e-05 22.8 3.4 3.4 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein DUF4924 PF16271.3 NM_001003668.2_2 - 0.0072 16.2 1.2 0.014 15.3 1.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4924) BAT PF15915.3 NM_001003668.2_2 - 0.025 14.3 0.8 0.053 13.3 0.8 1.5 1 0 0 1 1 1 0 GAF and HTH_10 associated domain DUF1635 PF07795.9 NM_001003668.2_2 - 0.063 13.1 4.1 0.12 12.2 4.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Glutaredoxin2_C PF04399.11 NM_001003668.2_2 - 0.11 12.2 0.3 0.29 10.8 0.3 1.7 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Spc7 PF08317.9 NM_001003668.2_2 - 0.14 10.9 23.4 0.035 12.8 6.4 2.9 1 1 0 2 2 2 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 NM_001003668.2_2 - 0.23 10.7 2.5 0.42 9.8 1.9 1.7 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Spc42p PF11544.6 NM_001003668.2_2 - 0.34 10.8 3.8 0.14 12.0 0.4 2.1 2 0 0 2 2 2 0 Spindle pole body component Spc42p CALCOCO1 PF07888.9 NM_001003668.2_2 - 0.65 8.4 25.3 1.7 6.9 23.7 1.8 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like MCC-bdg_PDZ PF10506.7 NM_001003668.2_2 - 0.7 9.8 9.8 0.13 12.2 2.9 3.2 2 2 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome TSC22 PF01166.16 NM_001003668.2_2 - 1.4 9.2 11.8 5.1 7.4 2.0 3.6 3 1 0 3 3 3 0 TSC-22/dip/bun family DUF1759 PF03564.13 NM_001003668.2_2 - 1.5 8.6 5.5 3.4 7.4 0.5 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1759) DUF2205 PF10224.7 NM_001003668.2_2 - 1.8 8.5 6.6 1.3 8.9 0.1 3.1 3 0 0 3 3 2 0 Predicted coiled-coil protein (DUF2205) CENP-F_leu_zip PF10473.7 NM_001003668.2_2 - 2.6 7.9 29.0 0.63 9.9 5.2 4.2 2 2 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DASH_Duo1 PF08651.8 NM_001003668.2_2 - 2.8 7.6 7.2 0.81 9.4 2.3 2.6 3 0 0 3 3 3 0 DASH complex subunit Duo1 IFT20 PF14931.4 NM_001003668.2_2 - 3 7.9 13.2 0.72 9.9 7.0 2.5 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 BRE1 PF08647.9 NM_001003668.2_2 - 3.5 7.6 14.4 1.3 9.0 1.6 3.4 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase DUF2927 PF11150.6 NM_001003668.2_2 - 4.3 7.2 9.5 0.15 12.0 2.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2927) V_ATPase_I PF01496.17 NM_001003668.2_2 - 7.5 4.2 17.0 0.64 7.7 3.8 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family FlaC_arch PF05377.9 NM_001003668.2_2 - 8.8 6.7 7.2 40 4.6 1.5 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF1192 PF06698.9 NM_001003668.2_2 - 8.9 6.3 8.4 0.68 9.9 0.6 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF1192) DUF1664 PF07889.10 NM_001003668.2_2 - 9.9 6.0 7.8 7.5 6.4 1.3 3.2 1 1 1 4 4 4 0 Protein of unknown function (DUF1664) Agouti PF05039.10 NM_001271806.1_3 - 2.3e-33 114.6 7.4 4.3e-33 113.7 7.4 1.4 1 0 0 1 1 1 1 Agouti protein Toxin_9 PF02819.13 NM_001271806.1_3 - 1.7 8.8 15.5 3.3 7.9 15.5 1.5 1 0 0 1 1 1 0 Spider toxin Pkinase_Tyr PF07714.15 NM_031880.3_1 - 4.8e-72 242.2 0.0 7.5e-72 241.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_031880.3_1 - 7.4e-32 110.6 0.0 1e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain UBA_4 PF14555.4 NM_031880.3_1 - 0.0045 16.6 0.0 0.04 13.6 0.0 2.1 2 0 0 2 2 2 1 UBA-like domain HOIP-UBA PF16678.3 NM_031880.3_1 - 0.0053 16.7 0.0 0.009 15.9 0.0 1.3 1 0 0 1 1 1 1 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase SH3_1 PF00018.26 NM_031880.3_1 - 0.03 13.8 0.0 0.059 12.8 0.0 1.5 1 0 0 1 1 1 0 SH3 domain SH3_2 PF07653.15 NM_031880.3_1 - 0.13 11.8 0.0 0.48 10.0 0.0 2.0 1 0 0 1 1 1 0 Variant SH3 domain SH3_9 PF14604.4 NM_031880.3_1 - 0.14 11.9 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain FH2 PF02181.21 NM_001285458.1_2 - 8.9e-91 304.6 7.5 8.9e-91 304.6 7.5 1.8 2 0 0 2 2 2 1 Formin Homology 2 Domain Lectin_C PF00059.19 NM_001190321.1_3 - 4e-21 75.6 3.2 4e-21 75.6 3.2 1.5 1 1 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 NM_001190321.1_3 - 0.095 12.2 3.5 0.14 11.6 3.5 1.2 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like RabGAP-TBC PF00566.16 NM_001081278.2_3 - 5.5e-52 176.4 1.4 1.3e-51 175.2 1.4 1.7 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3350 PF11830.6 NM_001081278.2_3 - 1.1e-27 96.0 5.3 1.1e-27 96.0 5.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3350) PID PF00640.21 NM_001081278.2_3 - 5.2e-15 55.6 2.5 4.8e-07 29.8 0.4 2.5 2 0 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) RecR PF02132.13 NM_001081278.2_3 - 0.033 13.6 0.7 0.11 12.0 0.7 1.9 1 0 0 1 1 1 0 RecR protein Autophagy_N PF03986.11 NM_026402.3_2 - 3.4e-52 175.9 0.7 5e-52 175.3 0.7 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.13 NM_026402.3_2 - 3.8e-20 72.1 4.1 9.5e-20 70.8 4.1 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.7 NM_026402.3_2 - 1.3e-15 56.4 0.7 2.4e-15 55.6 0.7 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal zf-H2C2_2 PF13465.4 NM_013744.3_1 - 6.8e-90 291.7 90.3 3.7e-09 36.5 0.5 14.8 15 0 0 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_013744.3_1 - 8.3e-69 224.3 99.4 1.2e-06 28.5 0.9 13.7 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_013744.3_1 - 3.3e-42 139.3 93.4 0.00074 20.0 3.3 13.9 13 0 0 13 13 13 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_013744.3_1 - 1.4e-26 91.8 84.4 0.0071 16.1 0.1 13.6 13 0 0 13 13 13 13 C2H2-type zinc finger KRAB PF01352.25 NM_013744.3_1 - 9.6e-23 79.5 0.1 1.7e-22 78.6 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_013744.3_1 - 1.6e-13 50.4 58.4 0.3 11.3 3.0 13.5 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_013744.3_1 - 1.3e-11 44.3 56.2 0.03 14.3 0.9 9.8 6 4 3 10 10 10 7 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_013744.3_1 - 2e-08 33.7 93.8 7.2e-05 22.3 0.3 13.5 14 0 0 14 14 14 7 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_013744.3_1 - 3.1e-06 27.7 57.1 0.24 12.1 3.7 7.5 2 2 6 8 8 8 7 zinc-ribbon family zf-met PF12874.5 NM_013744.3_1 - 0.00048 20.3 91.7 0.4 11.0 1.2 13.7 13 1 1 14 14 14 6 Zinc-finger of C2H2 type XPA_N PF01286.16 NM_013744.3_1 - 0.0071 16.2 61.0 3.7 7.5 0.1 13.0 13 0 0 13 13 13 2 XPA protein N-terminal C1_4 PF07975.10 NM_013744.3_1 - 0.17 12.0 58.8 1.2 9.4 3.1 9.3 3 3 7 11 11 11 0 TFIIH C1-like domain zf-H2C2_5 PF13909.4 NM_013744.3_1 - 1.5 8.5 0.0 1.5 8.5 0.0 14.1 13 4 0 13 13 13 0 C2H2-type zinc-finger domain HypA PF01155.17 NM_013744.3_1 - 1.8 8.5 53.5 4.8 7.1 0.7 7.6 2 2 4 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1-set PF07654.13 NM_001190325.1_1 - 9.4e-26 90.0 0.3 1.5e-25 89.3 0.3 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ig PF00047.23 NM_001190325.1_1 - 0.0055 16.7 0.4 0.0095 15.9 0.4 1.3 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 NM_001190325.1_1 - 0.047 13.6 0.1 0.076 13.0 0.1 1.3 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain SPRY PF00622.26 NM_001290506.1_3 - 6.9e-15 55.1 0.0 1.2e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_001290506.1_3 - 2.1e-10 39.9 0.0 5.2e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain fn3 PF00041.19 NM_001290506.1_3 - 2.2e-08 34.2 0.3 4.8e-08 33.1 0.3 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_UBOX PF13445.4 NM_001290506.1_3 - 6e-07 29.2 9.5 6e-07 29.2 9.5 4.4 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_001290506.1_3 - 1e-06 28.4 8.5 1e-06 28.4 8.5 4.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001290506.1_3 - 3.9e-06 26.5 11.7 3.9e-06 26.5 11.7 4.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001290506.1_3 - 1.7e-05 24.8 24.8 6.4e-05 23.0 11.5 3.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.4 NM_001290506.1_3 - 1.9e-05 24.6 12.3 1.9e-05 24.6 12.3 4.3 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 NM_001290506.1_3 - 0.00069 19.3 12.3 0.00069 19.3 12.3 6.1 10 1 0 10 10 9 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001290506.1_3 - 0.0035 17.1 10.8 0.0035 17.1 10.8 3.7 3 0 0 3 3 3 1 zinc-RING finger domain Pur_ac_phosph_N PF16656.3 NM_001290506.1_3 - 0.0089 16.5 0.3 0.017 15.5 0.3 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 NM_001290506.1_3 - 0.0091 16.3 0.0 0.024 15.0 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2369) Serine_rich PF08824.8 NM_001290506.1_3 - 0.84 9.5 4.9 2.8 7.8 4.9 1.7 1 1 0 1 1 1 0 Serine rich protein interaction domain Pkinase PF00069.23 NM_008857.3_2 - 4.8e-67 226.0 0.0 6.3e-67 225.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_008857.3_2 - 9.6e-34 116.7 0.0 1.4e-33 116.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 NM_008857.3_2 - 8e-15 54.4 0.0 1.6e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 PB1 domain C1_1 PF00130.20 NM_008857.3_2 - 3.2e-14 52.4 9.5 3.2e-14 52.4 9.5 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 NM_008857.3_2 - 8e-05 23.1 2.1 0.00017 22.1 2.1 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_008857.3_2 - 0.00017 20.9 0.0 0.00025 20.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like C1_2 PF03107.14 NM_008857.3_2 - 0.025 14.8 2.8 0.094 12.9 2.8 2.0 1 0 0 1 1 1 0 C1 domain Kdo PF06293.12 NM_008857.3_2 - 0.083 12.1 0.0 0.18 11.0 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_008857.3_2 - 0.14 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sugar_tr PF00083.22 NM_178934.4_3 - 2.8e-99 332.9 28.5 2.3e-73 247.5 17.9 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 NM_178934.4_3 - 1.6e-29 102.8 28.5 2.5e-25 89.0 19.4 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_3 PF16080.3 NM_178934.4_3 - 1.5 8.5 4.8 1.5 8.5 0.0 2.9 3 0 0 3 3 3 0 Bacteriophage holin family HP1 Peptidase_C2 PF00648.19 NM_001110504.1_2 - 4.5e-129 429.6 0.0 6.9e-129 429.0 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 NM_001110504.1_2 - 7e-53 178.6 0.0 2.1e-52 177.0 0.0 1.8 2 0 0 2 2 2 1 Calpain large subunit, domain III EF-hand_8 PF13833.4 NM_001110504.1_2 - 6.4e-13 48.1 7.6 4.8e-10 38.9 0.1 4.0 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_001110504.1_2 - 6e-10 37.8 4.6 0.011 15.1 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_001110504.1_2 - 6e-10 38.1 6.2 0.011 15.4 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 NM_001110504.1_2 - 1.1e-07 32.1 4.8 0.034 14.5 1.5 3.6 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_001110504.1_2 - 0.15 11.5 7.8 3.3 7.3 0.0 4.1 4 0 0 4 4 4 0 EF hand EF-hand_7 PF13499.4 NM_001111331.1_3 - 5.3e-20 71.5 1.2 1.7e-15 57.1 0.3 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_001111331.1_3 - 3.2e-19 66.8 5.7 4.4e-07 28.9 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 NM_001111331.1_3 - 5.3e-15 53.9 6.5 0.00014 21.4 0.0 4.1 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.4 NM_001111331.1_3 - 6e-12 44.4 2.7 0.00055 19.2 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 NM_001111331.1_3 - 9.3e-12 44.4 5.2 2.7e-06 26.9 0.2 3.1 2 1 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_001111331.1_3 - 0.00035 20.7 1.3 0.014 15.5 0.3 3.1 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_001111331.1_3 - 0.0021 17.9 0.8 0.058 13.2 0.0 2.5 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand IncA PF04156.12 NM_001111331.1_3 - 0.16 11.6 0.1 0.26 10.9 0.1 1.2 1 0 0 1 1 1 0 IncA protein ETX_MTX2 PF03318.11 NM_001111331.1_3 - 0.17 11.5 0.9 0.26 10.9 0.9 1.1 1 0 0 1 1 1 0 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Caleosin PF05042.11 NM_001111331.1_3 - 4.7 7.0 5.9 12 5.6 0.1 3.4 2 1 2 4 4 4 0 Caleosin related protein DUF4133 PF13571.4 NM_001111331.1_3 - 4.9 7.4 4.7 0.65 10.2 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) HLH PF00010.24 NM_009480.3_1 - 9.2e-18 63.8 0.2 1.4e-17 63.2 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Rootletin PF15035.4 NM_009480.3_1 - 0.013 15.5 4.3 0.02 14.8 4.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion HALZ PF02183.16 NM_009480.3_1 - 4.2 7.5 8.4 1.8 8.7 2.1 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper Kinesin PF00225.21 NM_010628.3_3 - 3.9e-97 325.0 0.7 7e-97 324.2 0.7 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 NM_010628.3_3 - 4e-23 81.9 0.1 1.4e-22 80.2 0.1 2.0 1 0 0 1 1 1 1 Microtubule binding AAA_22 PF13401.4 NM_010628.3_3 - 0.0031 17.6 2.9 0.13 12.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.4 NM_010628.3_3 - 0.0091 15.6 0.3 0.049 13.2 0.1 2.0 2 0 0 2 2 2 1 AAA domain Prismane PF03063.18 NM_010628.3_3 - 0.045 12.3 0.1 0.093 11.3 0.1 1.5 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family Laminin_II PF06009.10 NM_010628.3_3 - 0.05 13.5 8.8 0.14 12.1 4.6 2.6 2 0 0 2 2 2 0 Laminin Domain II ResIII PF04851.13 NM_010628.3_3 - 0.21 11.4 0.1 0.21 11.4 0.1 3.5 3 1 1 4 4 4 0 Type III restriction enzyme, res subunit KxDL PF10241.7 NM_010628.3_3 - 0.24 11.6 6.0 4.4 7.5 1.3 3.1 2 0 0 2 2 2 0 Uncharacterized conserved protein Mnd1 PF03962.13 NM_010628.3_3 - 0.36 10.6 11.3 0.076 12.7 5.9 2.2 2 0 0 2 2 2 0 Mnd1 family LEM PF03020.13 NM_007927.3_2 - 1.5e-15 56.3 0.0 2.2e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 LEM domain V-set PF07686.15 NM_145967.2_3 - 7.7e-09 35.6 0.0 1.4e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_145967.2_3 - 1.5e-07 31.8 0.0 2.8e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_145967.2_3 - 2.8e-07 30.4 0.5 7.3e-07 29.0 0.5 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_145967.2_3 - 3.6e-07 30.1 0.0 7.5e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_145967.2_3 - 0.063 13.5 0.2 1.4 9.2 0.2 2.3 1 1 0 1 1 1 0 Immunoglobulin domain Nipped-B_C PF12830.5 NM_201232.2_2 - 4.3e-67 225.6 1.9 4.3e-67 225.6 1.9 4.4 5 0 0 5 5 5 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.5 NM_201232.2_2 - 5.4e-13 48.7 1.5 4.2e-11 42.7 0.2 3.3 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.4 NM_201232.2_2 - 1e-05 25.7 0.1 9 6.6 0.0 4.6 4 1 1 5 5 5 4 HEAT repeats HEAT PF02985.20 NM_201232.2_2 - 0.00014 21.7 1.1 0.22 11.7 0.0 5.7 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.4 NM_201232.2_2 - 0.00034 20.9 0.3 1.5 9.3 0.1 4.8 4 1 1 5 5 5 1 HEAT-like repeat Cnd1 PF12717.5 NM_201232.2_2 - 0.00093 19.1 8.8 0.09 12.6 1.5 5.0 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.5 NM_201232.2_2 - 0.0035 16.5 7.5 0.014 14.5 0.0 3.8 4 0 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain DNA_repr_REX1B PF14966.4 NM_201232.2_2 - 0.017 15.7 0.1 0.25 11.9 0.0 3.0 3 0 0 3 3 3 0 DNA repair REX1-B Trypsin PF00089.24 NM_145561.2_3 - 6.7e-67 225.4 0.6 8.8e-67 225.0 0.6 1.1 1 0 0 1 1 1 1 Trypsin SEA PF01390.18 NM_145561.2_3 - 4.1e-23 81.5 1.0 2.2e-22 79.2 1.0 2.1 2 0 0 2 2 2 1 SEA domain DUF1986 PF09342.9 NM_145561.2_3 - 7.7e-07 29.4 0.1 1.7e-06 28.3 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_145561.2_3 - 5.8e-06 27.1 0.2 9.8e-06 26.4 0.2 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain HLH PF00010.24 NM_013904.1_1 - 6.3e-17 61.1 2.9 1.2e-16 60.3 2.9 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.11 NM_013904.1_1 - 9.2e-15 54.4 0.1 4.7e-14 52.2 0.1 2.1 2 0 0 2 2 2 1 Hairy Orange dCache_2 PF08269.9 NM_013904.1_1 - 0.077 12.0 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Cache domain I-set PF07679.14 NM_026831.1_3 - 1.6e-28 98.5 0.0 2.1e-14 53.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_026831.1_3 - 1.5e-18 67.0 0.2 1.4e-08 35.1 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain fn3 PF00041.19 NM_026831.1_3 - 1.5e-12 47.6 0.0 2.4e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Fibronectin type III domain Ig_2 PF13895.4 NM_026831.1_3 - 3.2e-10 40.1 0.2 0.00016 21.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_026831.1_3 - 2e-08 34.2 0.3 0.00033 20.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_026831.1_3 - 1.2e-06 28.5 0.2 0.17 11.9 0.0 3.3 2 2 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_026831.1_3 - 0.0089 15.9 0.1 5.6 7.0 0.0 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain DnaJ PF00226.29 NM_025489.3_1 - 1.8e-26 91.9 0.4 2.6e-26 91.4 0.4 1.3 1 0 0 1 1 1 1 DnaJ domain Prominin PF05478.9 NM_025489.3_1 - 3.5 5.3 12.4 4.9 4.8 12.4 1.1 1 0 0 1 1 1 0 Prominin EF_assoc_2 PF08356.10 NM_021536.7_2 - 3.3e-35 119.8 0.0 1.9e-34 117.4 0.0 2.3 2 0 0 2 2 2 1 EF hand associated EF_assoc_1 PF08355.10 NM_021536.7_2 - 3.6e-29 100.1 1.7 1.1e-28 98.5 0.9 2.1 2 0 0 2 2 2 1 EF hand associated Ras PF00071.20 NM_021536.7_2 - 8.3e-27 93.6 0.1 4.7e-19 68.4 0.0 2.5 2 1 0 2 2 2 2 Ras family Roc PF08477.11 NM_021536.7_2 - 5.6e-11 42.6 0.0 4.7e-08 33.1 0.0 3.1 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_021536.7_2 - 1e-06 28.2 0.0 0.00048 19.5 0.0 3.1 3 0 0 3 3 3 1 ADP-ribosylation factor family EF-hand_7 PF13499.4 NM_021536.7_2 - 1.2e-05 25.5 0.1 0.024 15.0 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair DUF258 PF03193.14 NM_021536.7_2 - 3.8e-05 23.5 0.5 0.75 9.5 0.1 4.1 4 0 0 4 4 4 1 Protein of unknown function, DUF258 SRPRB PF09439.8 NM_021536.7_2 - 4.1e-05 22.9 0.8 0.00048 19.5 0.0 2.4 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit EF-hand_1 PF00036.30 NM_021536.7_2 - 5.9e-05 22.2 2.9 0.17 11.4 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_021536.7_2 - 8.1e-05 22.1 2.6 0.034 14.0 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain PduV-EutP PF10662.7 NM_021536.7_2 - 0.00027 20.6 0.2 0.16 11.6 0.0 2.8 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.4 NM_021536.7_2 - 0.0028 17.8 0.0 1.4 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.4 NM_021536.7_2 - 0.0037 17.5 0.0 0.52 10.5 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.21 NM_021536.7_2 - 0.0048 16.8 0.1 0.06 13.3 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase Rad4 PF03835.13 NM_021536.7_2 - 0.0066 16.0 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain RNA_helicase PF00910.20 NM_021536.7_2 - 0.011 15.9 0.0 6 7.2 0.0 3.2 3 0 0 3 3 3 0 RNA helicase Septin PF00735.16 NM_021536.7_2 - 0.016 14.3 0.0 4 6.4 0.0 2.3 2 0 0 2 2 2 0 Septin ABC_tran PF00005.25 NM_021536.7_2 - 0.029 14.7 0.0 13 6.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_14 PF13173.4 NM_021536.7_2 - 0.034 14.0 0.0 6 6.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain EF-hand_8 PF13833.4 NM_021536.7_2 - 0.11 12.2 0.6 2.3 8.0 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain pair AAA PF00004.27 NM_021536.7_2 - 0.13 12.6 0.0 4.2 7.7 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.21 NM_021536.7_2 - 0.16 11.9 0.1 14 5.5 0.0 2.4 2 0 0 2 2 2 0 Dynamin family AAA_5 PF07728.12 NM_021536.7_2 - 0.18 11.7 0.0 3.7 7.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) EF-hand_5 PF13202.4 NM_021536.7_2 - 0.38 10.2 2.5 4.3 6.9 0.1 2.5 2 0 0 2 2 2 0 EF hand 7tm_4 PF13853.4 NM_146312.2_1 - 1.8e-73 247.6 18.3 2.2e-73 247.3 18.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146312.2_1 - 3.8e-15 55.7 19.4 1.7e-14 53.6 19.4 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146312.2_1 - 2.1e-08 33.7 18.9 8.4e-08 31.8 18.9 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_146312.2_1 - 0.00041 19.6 9.7 0.00041 19.6 9.7 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Ldl_recept_a PF00057.16 NM_001290784.1_1 - 3.2e-32 110.3 40.2 7.5e-12 45.1 8.6 3.5 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Paralemmin PF03285.13 NM_023128.4_3 - 3.7e-122 407.7 8.4 3.7e-122 407.7 8.4 1.6 2 0 0 2 2 2 1 Paralemmin RhoGAP PF00620.25 NM_001316713.1_1 - 4.3e-43 146.6 0.0 7.2e-43 145.9 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Spt20 PF12090.6 NM_001316713.1_1 - 1.1 8.7 13.2 2 7.8 13.2 1.4 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.11 NM_001316713.1_1 - 6 6.6 22.5 9.2 6.0 22.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BAR PF03114.16 NM_001316713.1_2 - 4.5e-57 193.3 5.9 6.2e-57 192.8 5.9 1.1 1 0 0 1 1 1 1 BAR domain FliJ PF02050.14 NM_001316713.1_2 - 0.34 11.0 0.1 0.34 11.0 0.1 2.3 2 1 0 2 2 2 0 Flagellar FliJ protein BAR_2 PF10455.7 NM_001316713.1_2 - 0.56 9.2 2.1 2.2 7.2 2.1 1.7 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking WD40 PF00400.30 NM_001014981.1_2 - 1.4e-17 63.6 19.9 0.00031 21.4 0.2 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001014981.1_2 - 2.5e-08 34.0 0.0 0.19 11.9 0.0 6.3 4 3 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 NM_001014981.1_2 - 0.00015 20.8 1.2 0.33 9.8 0.3 3.3 4 0 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein RhoGAP PF00620.25 NM_020260.2_3 - 1.2e-44 151.7 0.0 1.9e-44 151.0 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Oxysterol_BP PF01237.16 NM_027881.3_3 - 3.3e-133 444.0 0.1 5.4e-133 443.3 0.1 1.3 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.4 NM_027881.3_3 - 1.1e-11 44.7 0.2 1.9e-11 43.9 0.2 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 NM_027881.3_3 - 2.2e-07 31.2 1.6 4.8e-07 30.1 1.6 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_027881.3_3 - 1.1 9.5 4.7 39 4.6 4.7 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain Abhydrolase_3 PF07859.11 NM_001101531.1_1 - 2.2e-46 158.2 0.0 4.8e-33 114.7 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.26 NM_001101531.1_1 - 3.3e-09 36.1 0.0 1.3e-08 34.1 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.7 NM_001101531.1_1 - 0.00012 20.9 0.0 0.00018 20.4 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Esterase PF00756.18 NM_001101531.1_1 - 0.00094 18.8 0.0 0.0034 16.9 0.0 1.8 1 1 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.19 NM_001101531.1_1 - 0.0093 15.3 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Lipase_3 PF01764.23 NM_001101531.1_1 - 0.1 12.3 0.0 0.41 10.4 0.0 1.8 2 0 0 2 2 2 0 Lipase (class 3) Esterase_phd PF10503.7 NM_001101531.1_1 - 0.12 11.8 0.0 0.84 8.9 0.0 2.0 2 0 0 2 2 2 0 Esterase PHB depolymerase TAS2R PF05296.11 NM_001167169.1_1 - 1.3e-15 57.2 12.6 1.7e-15 56.8 12.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 NM_001167169.1_1 - 6.9e-14 52.0 10.9 8.9e-14 51.6 10.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 NM_001167169.1_1 - 8.8e-06 25.0 13.3 1.2e-05 24.5 13.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1700 PF08006.9 NM_001167169.1_1 - 0.12 11.8 0.2 0.12 11.8 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1700) Fer4_9 PF13187.4 NM_001167169.1_3 - 0.11 12.5 8.0 1.7 8.7 0.5 3.3 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_16 PF13484.4 NM_001167169.1_3 - 0.34 11.7 7.9 8.3 7.3 0.5 3.2 3 0 0 3 3 3 0 4Fe-4S double cluster binding domain Fer4_4 PF12800.5 NM_001167169.1_3 - 0.48 10.9 0.1 0.48 10.9 0.1 4.2 4 0 0 4 4 4 0 4Fe-4S binding domain Fer4_6 PF12837.5 NM_001167169.1_3 - 0.51 10.4 16.1 1.3 9.1 0.5 3.6 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_3 PF12798.5 NM_001167169.1_3 - 0.63 11.0 20.9 2.8 8.9 1.7 4.3 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4 PF00037.25 NM_001167169.1_3 - 1.5 8.6 14.4 0.84 9.4 1.2 3.6 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_7 PF12838.5 NM_001167169.1_3 - 5.4 7.5 13.6 10 6.7 0.5 3.3 3 0 0 3 3 3 0 4Fe-4S dicluster domain 7tm_4 PF13853.4 NM_146725.1_1 - 1.8e-59 201.6 16.0 2.1e-59 201.4 16.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146725.1_1 - 1.5e-23 83.3 16.6 2.7e-23 82.4 16.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146725.1_1 - 9e-05 21.8 19.4 0.00013 21.4 19.4 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Antimicrobial_5 PF08026.9 NM_146725.1_2 - 7.8 6.4 6.6 1.1 9.2 1.4 2.2 2 0 0 2 2 2 0 Bee antimicrobial peptide TAS2R PF05296.11 NM_020503.2_2 - 5.8e-89 298.0 31.4 6.6e-89 297.9 31.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) ig PF00047.23 NM_001113474.1_1 - 0.082 13.0 0.2 0.082 13.0 0.2 2.0 3 0 0 3 3 3 0 Immunoglobulin domain 7tm_4 PF13853.4 NM_146838.2_1 - 6.7e-51 173.5 16.9 8.3e-51 173.2 16.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146838.2_1 - 6.5e-19 68.1 17.7 2.5e-18 66.2 17.7 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Defensin_propep PF00879.16 NM_001177481.1_2 - 4e-22 78.2 0.1 4.9e-22 77.9 0.1 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 NM_001177481.1_2 - 4.5e-08 33.4 17.2 6.7e-08 32.8 17.2 1.3 1 0 0 1 1 1 1 Mammalian defensin MF_alpha_N PF05436.9 NM_001177481.1_2 - 0.036 13.8 0.0 0.048 13.4 0.0 1.1 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus zf-RING_2 PF13639.4 NM_001290556.1_1 - 5.7e-10 39.2 13.8 1.1e-09 38.2 13.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 NM_001290556.1_1 - 4.8e-06 26.2 10.0 8.9e-06 25.4 10.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_001290556.1_1 - 6.5e-06 26.2 10.0 1.4e-05 25.1 10.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 NM_001290556.1_1 - 1.8e-05 24.4 13.7 3.1e-05 23.6 13.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001290556.1_1 - 2.2e-05 24.2 6.5 2.2e-05 24.2 6.5 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.3 NM_001290556.1_1 - 4.3e-05 23.0 7.8 0.00011 21.6 7.8 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.4 NM_001290556.1_1 - 0.025 14.4 15.7 0.045 13.6 15.7 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-ANAPC11 PF12861.5 NM_001290556.1_1 - 0.038 13.9 10.2 0.086 12.8 10.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.4 NM_001290556.1_1 - 0.12 12.1 14.5 0.2 11.4 14.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.3 NM_001290556.1_1 - 0.34 10.4 12.7 0.6 9.6 12.7 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Cathelicidins PF00666.15 NM_027852.2_2 - 0.00073 19.7 0.7 0.0014 18.8 0.7 1.4 1 1 0 1 1 1 1 Cathelicidin Cystatin PF00031.19 NM_027852.2_2 - 0.066 13.3 0.0 0.092 12.9 0.0 1.2 1 0 0 1 1 1 0 Cystatin domain Dynein_heavy PF03028.13 NM_019536.1_2 - 7.1e-241 801.2 0.0 2.7e-240 799.2 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.10 NM_019536.1_2 - 5e-160 533.7 14.8 2.7e-159 531.2 14.8 2.5 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.11 NM_019536.1_2 - 7.3e-138 459.9 7.9 7.3e-138 459.9 7.9 4.3 3 2 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 NM_019536.1_2 - 4e-101 337.5 0.3 1.7e-100 335.4 0.1 2.1 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.5 NM_019536.1_2 - 2.5e-86 288.2 1.1 2.5e-86 288.2 1.1 4.1 4 0 0 4 4 3 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 NM_019536.1_2 - 1.9e-84 282.9 0.0 5.5e-84 281.4 0.0 1.9 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 NM_019536.1_2 - 1.1e-58 198.6 0.6 7.7e-58 195.8 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 MT PF12777.5 NM_019536.1_2 - 2.6e-50 171.3 12.8 4.7e-50 170.4 12.8 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 NM_019536.1_2 - 6.1e-27 94.2 2.7 5.2e-07 29.6 0.0 5.9 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 NM_019536.1_2 - 9.7e-10 38.7 0.2 0.021 15.0 0.0 5.3 4 0 0 4 4 4 2 AAA domain AAA PF00004.27 NM_019536.1_2 - 2.8e-08 34.1 0.2 0.56 10.5 0.0 5.3 5 0 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 NM_019536.1_2 - 9.3e-08 32.5 0.2 2.6 8.2 0.0 6.1 4 1 1 5 5 5 2 AAA ATPase domain DUF258 PF03193.14 NM_019536.1_2 - 1.4e-05 24.9 1.5 0.0014 18.4 0.0 3.9 4 0 0 4 4 4 1 Protein of unknown function, DUF258 AAA_18 PF13238.4 NM_019536.1_2 - 5.5e-05 23.5 0.0 0.32 11.4 0.0 4.4 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.18 NM_019536.1_2 - 0.00029 19.8 0.5 0.74 8.7 0.0 3.0 2 0 0 2 2 2 2 Type II/IV secretion system protein Sigma54_activat PF00158.24 NM_019536.1_2 - 0.00079 19.0 0.3 1.5 8.4 0.0 3.6 3 0 0 3 3 3 1 Sigma-54 interaction domain RNA_helicase PF00910.20 NM_019536.1_2 - 0.0011 19.2 0.1 7.1 6.9 0.0 3.8 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.4 NM_019536.1_2 - 0.0016 18.5 0.7 32 4.5 0.0 5.1 5 0 0 5 5 5 0 AAA domain Plasmid_RAQPRD PF09686.8 NM_019536.1_2 - 0.034 14.2 1.2 4 7.6 0.0 4.1 3 0 0 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Spo7_2_N PF15407.4 NM_019536.1_2 - 0.037 13.6 0.0 0.37 10.4 0.0 2.7 2 0 0 2 2 2 0 Sporulation protein family 7 FtsK_SpoIIIE PF01580.16 NM_019536.1_2 - 0.046 12.9 0.1 0.63 9.2 0.1 2.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_29 PF13555.4 NM_019536.1_2 - 0.087 12.4 0.1 6.3 6.5 0.0 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain PhoH PF02562.14 NM_019536.1_2 - 0.12 11.7 1.4 1.4 8.2 0.0 3.2 3 0 0 3 3 3 0 PhoH-like protein AAA_30 PF13604.4 NM_019536.1_2 - 0.14 11.7 4.1 5.7 6.5 0.0 3.6 3 0 0 3 3 3 0 AAA domain TSC22 PF01166.16 NM_001310647.1_1 - 2.4e-28 98.1 5.9 3.5e-28 97.6 5.9 1.2 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.11 NM_001310647.1_1 - 0.0003 21.2 1.3 0.00049 20.5 1.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF972) ZapB PF06005.10 NM_001310647.1_1 - 0.015 15.6 6.1 0.026 14.8 6.1 1.3 1 0 0 1 1 1 0 Cell division protein ZapB K-box PF01486.15 NM_001310647.1_1 - 0.017 15.2 2.6 0.029 14.4 2.6 1.3 1 0 0 1 1 1 0 K-box region DivIC PF04977.13 NM_001310647.1_1 - 0.025 14.2 4.0 0.043 13.4 4.0 1.4 1 0 0 1 1 1 0 Septum formation initiator Fzo_mitofusin PF04799.11 NM_001310647.1_1 - 0.54 9.6 2.3 0.78 9.1 2.3 1.1 1 0 0 1 1 1 0 fzo-like conserved region bZIP_2 PF07716.13 NM_001310647.1_1 - 1.4 9.0 5.9 2.7 8.0 5.9 1.4 1 0 0 1 1 1 0 Basic region leucine zipper TLD PF07534.14 NM_001130163.1_2 - 5.1e-38 130.3 0.4 9.1e-38 129.5 0.4 1.4 1 0 0 1 1 1 1 TLD LysM PF01476.18 NM_001130163.1_2 - 5.8e-07 29.4 0.0 1.2e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 LysM domain GRAM PF02893.18 NM_001130163.1_2 - 0.023 14.4 0.0 0.057 13.1 0.0 1.6 1 0 0 1 1 1 0 GRAM domain PX PF00787.22 NM_021429.3_1 - 6.9e-15 54.9 0.0 1.3e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 PX domain CASP_C PF08172.10 NM_198602.3_2 - 2.2e-58 197.5 2.1 2.2e-58 197.5 2.1 5.5 2 2 2 4 4 4 1 CASP C terminal DUF2205 PF10224.7 NM_198602.3_2 - 0.006 16.4 0.1 0.006 16.4 0.1 6.5 5 2 1 6 6 6 1 Predicted coiled-coil protein (DUF2205) NDUF_B8 PF05821.9 NM_198602.3_2 - 0.079 12.7 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) ZapB PF06005.10 NM_198602.3_2 - 0.28 11.5 0.0 0.28 11.5 0.0 7.7 5 2 1 6 6 6 0 Cell division protein ZapB HOOK PF05622.10 NM_198602.3_2 - 7.1 4.5 74.5 0.6 8.0 58.7 3.4 2 1 1 3 3 3 0 HOOK protein DUF4407 PF14362.4 NM_198602.3_2 - 9.7 5.3 54.9 5.3 6.2 0.0 4.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) RNase_T PF00929.22 NM_001162939.1_3 - 2.9e-15 57.1 0.0 4.4e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.18 NM_001162939.1_3 - 0.0019 17.8 0.0 0.0039 16.8 0.0 1.4 1 1 0 1 1 1 1 3'-5' exonuclease HMG_box PF00505.17 NM_020618.4_2 - 9.5e-18 64.2 1.7 9.5e-18 64.2 1.7 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_020618.4_2 - 1.4e-05 25.5 0.6 1.4e-05 25.5 0.6 2.4 2 0 0 2 2 2 1 HMG-box domain ApoM PF11032.6 NM_018816.1_3 - 5.4e-95 316.3 0.0 6.2e-95 316.1 0.0 1.0 1 0 0 1 1 1 1 ApoM domain Lipocalin PF00061.21 NM_018816.1_3 - 0.023 14.8 0.0 0.094 12.8 0.0 1.8 1 1 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family XRCC1_N PF01834.14 NM_011644.3_3 - 1.2e-51 174.6 0.0 1.9e-51 173.9 0.0 1.3 1 0 0 1 1 1 1 XRCC1 N terminal domain Ion_trans PF00520.29 NM_011644.3_3 - 7.8e-25 87.4 22.8 7.8e-25 87.4 22.8 1.9 2 1 0 2 2 2 1 Ion transport protein TRP_2 PF08344.9 NM_011644.3_3 - 2.4e-22 78.8 1.6 4.9e-22 77.8 1.6 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II PKD_channel PF08016.10 NM_011644.3_3 - 2e-10 39.8 12.2 2.9e-10 39.3 12.2 1.2 1 0 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.5 NM_011644.3_3 - 2.7e-06 27.7 0.0 0.0097 16.3 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_011644.3_3 - 0.15 12.5 0.3 12 6.7 0.0 3.7 3 0 0 3 3 3 0 Ankyrin repeat Ank PF00023.28 NM_011644.3_3 - 0.35 11.3 1.9 0.81 10.1 0.0 2.6 3 0 0 3 3 3 0 Ankyrin repeat DUF4749 PF15936.3 NM_001039076.2_3 - 1.2e-20 74.3 0.1 2.8e-20 73.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.22 NM_001039076.2_3 - 3.9e-16 59.0 0.0 7e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001039076.2_3 - 8e-05 22.8 0.0 0.00016 21.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain DUF3854 PF12965.5 NM_001039076.2_3 - 0.079 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) Ephrin PF00812.15 NM_007909.3_3 - 6.1e-35 120.1 0.0 8.4e-35 119.6 0.0 1.2 1 0 0 1 1 1 1 Ephrin NHR2 PF08788.9 NM_001111026.2_2 - 7.8e-39 131.2 8.8 7.8e-39 131.2 8.8 2.1 2 0 0 2 2 2 1 NHR2 domain like TAFH PF07531.12 NM_001111026.2_2 - 5.5e-34 115.9 1.6 1.2e-33 114.9 1.6 1.6 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.16 NM_001111026.2_2 - 4e-07 29.9 18.2 1.4e-06 28.2 18.2 2.0 1 0 0 1 1 1 1 MYND finger DUF3731 PF12531.6 NM_001111026.2_2 - 0.076 12.7 0.8 0.13 11.9 0.8 1.3 1 0 0 1 1 1 0 DNA-K related protein Efg1 PF10153.7 NM_001111026.2_2 - 0.16 12.2 1.9 0.39 11.0 1.9 1.5 1 0 0 1 1 1 0 rRNA-processing protein Efg1 vATP-synt_E PF01991.16 NM_001111026.2_2 - 5.8 6.1 11.1 9 5.5 11.1 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit DUF485 PF04341.10 NM_001111026.2_3 - 0.1 12.4 2.0 0.17 11.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF485 VWC PF00093.16 NM_001029985.4_3 - 1.8e-112 367.5 414.3 5.1e-11 42.6 13.1 21.0 20 1 1 21 21 21 19 von Willebrand factor type C domain VWD PF00094.23 NM_001029985.4_3 - 2e-37 128.8 0.0 3.3e-37 128.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain TILa PF12714.5 NM_001029985.4_3 - 6.1e-21 74.0 332.0 0.0018 18.1 7.3 22.0 21 0 0 21 21 21 15 TILa domain ATG16 PF08614.9 NM_001029985.4_3 - 0.047 13.7 1.0 0.067 13.2 1.0 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DivIC PF04977.13 NM_001029985.4_3 - 0.26 10.9 0.3 0.42 10.3 0.3 1.2 1 0 0 1 1 1 0 Septum formation initiator Nnf1 PF03980.12 NM_001029985.4_3 - 0.36 11.1 1.4 0.6 10.4 1.4 1.3 1 0 0 1 1 1 0 Nnf1 bZIP_2 PF07716.13 NM_001029985.4_3 - 1.5 8.8 3.6 2.6 8.0 3.6 1.3 1 0 0 1 1 1 0 Basic region leucine zipper Exo_endo_phos PF03372.21 NM_001199020.1_1 - 9.3e-14 51.5 0.0 1.4e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Filament PF00038.19 NM_201639.2_1 - 5.4e-34 118.1 33.0 5.4e-34 118.1 33.0 1.7 2 0 0 2 2 2 1 Intermediate filament protein DUF3450 PF11932.6 NM_201639.2_1 - 5.1 6.2 25.9 6.1 5.9 14.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) THDPS_M PF14789.4 NM_001162933.1_1 - 0.036 14.0 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase middle Ribosomal_L16 PF00252.16 NM_001162933.1_3 - 6.7e-44 149.0 0.3 6.7e-44 149.0 0.3 2.1 2 0 0 2 2 2 1 Ribosomal protein L16p/L10e DUF1669 PF07894.10 NM_134087.2_1 - 7.5e-102 340.4 0.0 1.1e-101 339.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) PLDc_2 PF13091.4 NM_134087.2_1 - 9.8e-06 25.4 0.0 0.0001 22.1 0.0 2.1 2 0 0 2 2 2 1 PLD-like domain CTD PF12815.5 NM_134087.2_1 - 0.033 14.6 18.3 0.14 12.6 18.3 2.1 1 1 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 Regulator_TrmB PF11495.6 NM_134087.2_1 - 0.22 10.6 0.1 0.34 9.9 0.1 1.2 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB zf-Di19 PF05605.10 NM_019715.2_3 - 3.1e-22 78.5 1.6 3.1e-22 78.5 1.6 2.5 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding ZZ PF00569.15 NM_019715.2_3 - 1.3e-10 40.8 6.5 1.3e-10 40.8 6.5 2.8 3 0 0 3 3 3 1 Zinc finger, ZZ type Di19_C PF14571.4 NM_019715.2_3 - 0.014 15.8 1.2 0.014 15.8 1.2 2.1 1 1 1 2 2 2 0 Stress-induced protein Di19, C-terminal zf-C2H2 PF00096.24 NM_019715.2_3 - 0.03 14.6 0.3 0.03 14.6 0.3 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type TFIIA PF03153.11 NM_019715.2_3 - 3.7 7.3 8.1 5.2 6.8 8.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ion_trans PF00520.29 NM_001042528.2_1 - 2.8e-248 819.1 82.8 1.8e-67 227.0 0.9 4.3 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 NM_001042528.2_1 - 7.9e-38 128.0 0.0 4.2e-37 125.6 0.0 2.3 3 0 0 3 3 3 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 NM_001042528.2_1 - 8.5e-32 109.1 0.0 1.8e-31 108.1 0.0 1.6 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 NM_001042528.2_1 - 7e-09 34.7 26.2 6.4e-07 28.3 7.7 9.1 6 4 3 10 10 10 5 Polycystin cation channel Ferlin_C PF16165.3 NM_001042528.2_1 - 1.2 8.9 0.0 1.2 8.9 0.0 3.2 3 0 0 3 3 3 0 Ferlin C-terminus DSPc PF00782.18 NM_001159376.1_3 - 1.6e-29 102.2 0.0 2.4e-29 101.7 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 NM_001159376.1_3 - 0.00024 21.2 0.0 0.00036 20.6 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 NM_001159376.1_3 - 0.0013 18.2 0.1 0.002 17.6 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RRM_1 PF00076.20 NM_010771.6_2 - 1.9e-08 33.9 0.0 0.0021 17.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_jaz PF12171.6 NM_010771.6_2 - 5.5 7.3 16.3 1.5 9.1 1.1 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding 7tm_4 PF13853.4 NM_146477.2_2 - 2.1e-51 175.2 8.0 2.7e-51 174.8 8.0 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146477.2_2 - 1.1e-26 93.5 12.0 1.9e-26 92.7 12.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146477.2_2 - 0.00023 20.5 12.2 0.00061 19.1 12.2 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 NM_146477.2_2 - 0.00029 20.3 5.8 0.00061 19.3 5.8 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srv PF10323.7 NM_146477.2_2 - 0.005 16.1 14.6 0.011 15.0 14.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF872 PF05915.10 NM_146477.2_2 - 0.019 15.0 3.4 0.61 10.2 0.2 2.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) ubiquitin PF00240.21 NM_018798.2_1 - 5.7e-18 64.3 1.7 9.2e-18 63.6 1.7 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.29 NM_018798.2_1 - 2.3e-07 30.4 1.0 5.8e-07 29.2 1.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.6 NM_018798.2_1 - 4.7e-07 29.4 0.9 7.8e-07 28.7 0.9 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.8 NM_018798.2_1 - 0.0016 19.0 0.0 0.0033 17.9 0.0 1.6 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD Rad60-SLD_2 PF13881.4 NM_018798.2_1 - 0.0016 18.4 0.4 0.0034 17.4 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 NM_018798.2_1 - 0.0071 16.8 0.1 0.017 15.6 0.1 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Atg8 PF02991.14 NM_018798.2_1 - 0.01 15.9 0.1 0.02 15.0 0.1 1.4 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like Tir_receptor_C PF07489.9 NM_018798.2_1 - 0.038 13.8 17.6 0.054 13.3 5.6 2.7 3 0 0 3 3 3 0 Translocated intimin receptor (Tir) C-terminus HOIP-UBA PF16678.3 NM_018798.2_1 - 0.15 11.9 0.1 0.35 10.7 0.1 1.6 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase zf-B_box PF00643.22 NM_001039466.1_3 - 6.9e-10 38.8 6.4 6.9e-10 38.8 6.4 4.5 3 1 0 3 3 3 2 B-box zinc finger zf-RING_UBOX PF13445.4 NM_001039466.1_3 - 2.3e-07 30.6 2.3 2.3e-07 30.6 2.3 3.6 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_001039466.1_3 - 3.3e-07 29.9 2.4 3.3e-07 29.9 2.4 4.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001039466.1_3 - 3.7e-07 29.8 1.3 3.7e-07 29.8 1.3 4.0 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001039466.1_3 - 5.3e-06 26.1 2.6 5.3e-06 26.1 2.6 4.5 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_001039466.1_3 - 4.1e-05 23.5 3.5 4.1e-05 23.5 3.5 4.0 5 0 0 5 5 5 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 NM_001039466.1_3 - 0.00015 21.5 1.8 0.00015 21.5 1.8 4.7 4 1 0 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_001039466.1_3 - 0.003 17.6 1.7 0.003 17.6 1.7 5.4 4 1 0 4 4 4 1 Ring finger domain fn3 PF00041.19 NM_001039466.1_3 - 0.0032 17.6 0.0 0.0058 16.8 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain zf-piccolo PF05715.11 NM_001039466.1_3 - 0.25 11.4 22.2 3.3 7.8 1.7 4.2 3 0 0 3 3 3 0 Piccolo Zn-finger Trypsin PF00089.24 NM_001081688.2_1 - 6.1e-202 667.0 0.0 1.5e-68 230.8 0.0 3.2 3 0 0 3 3 3 3 Trypsin DUF1986 PF09342.9 NM_001081688.2_1 - 1e-13 51.6 0.0 0.0024 18.1 0.0 3.7 3 1 0 3 3 3 3 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_001081688.2_1 - 3.5e-13 50.5 0.0 0.0026 18.5 0.0 3.7 3 0 0 3 3 3 3 Trypsin-like peptidase domain SEA PF01390.18 NM_001081688.2_1 - 8.8e-08 32.3 0.0 1.6e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 SEA domain Ldl_recept_a PF00057.16 NM_001081688.2_1 - 2.2e-06 27.6 14.2 5.1e-06 26.5 14.2 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF4951 PF16309.3 NM_001081688.2_1 - 0.41 10.6 1.9 14 5.6 0.0 3.8 5 0 0 5 5 5 0 Domian of unknown function (DUF4951) BTB PF00651.29 NM_028356.2_3 - 6.4e-20 71.3 0.3 2.6e-19 69.3 0.2 2.0 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2 PF00096.24 NM_028356.2_3 - 1.9e-05 24.7 21.1 0.0037 17.5 6.7 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.5 NM_028356.2_3 - 0.00011 22.3 3.4 0.15 12.2 0.1 2.8 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.4 NM_028356.2_3 - 0.00021 21.7 19.6 0.014 16.1 4.9 3.3 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2HE PF16278.3 NM_028356.2_3 - 0.07 13.5 0.2 0.07 13.5 0.2 3.3 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-FCS PF06467.12 NM_028356.2_3 - 0.15 11.9 2.7 2.3 8.1 0.3 2.5 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif PyrI_C PF02748.13 NM_028356.2_3 - 0.28 11.0 2.1 6.8 6.6 0.1 2.7 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.13 NM_028356.2_3 - 2.4 8.1 15.5 1 9.4 2.4 2.5 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_6 PF13912.4 NM_028356.2_3 - 2.6 8.0 15.5 0.096 12.5 5.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger FYVE PF01363.19 NM_028356.2_3 - 2.7 8.1 7.1 19 5.4 2.7 2.4 2 0 0 2 2 2 0 FYVE zinc finger Zn_ribbon_recom PF13408.4 NM_028356.2_3 - 4.3 7.8 6.1 2.5 8.5 2.0 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-C2H2_jaz PF12171.6 NM_028356.2_3 - 7.9 6.8 8.8 5.9 7.2 1.2 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding SNF2_N PF00176.21 NM_172937.3_1 - 1.2e-121 405.6 0.1 1.2e-121 405.6 0.1 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain Linker_histone PF00538.17 NM_172937.3_1 - 8.2e-16 58.0 0.0 3.5e-15 56.0 0.0 2.2 1 0 0 1 1 1 1 linker histone H1 and H5 family Helicase_C PF00271.29 NM_172937.3_1 - 2.1e-07 31.2 0.0 6e-07 29.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 NM_172937.3_1 - 8e-06 25.5 9.8 8e-06 25.5 9.8 4.1 3 1 0 3 3 3 1 PHD-finger zf-C3HC4_3 PF13920.4 NM_172937.3_1 - 0.00019 21.1 10.2 0.00019 21.1 10.2 3.2 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_172937.3_1 - 0.0015 18.4 7.3 0.0015 18.4 7.3 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_172937.3_1 - 0.0026 17.8 11.0 0.0026 17.8 11.0 3.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.23 NM_172937.3_1 - 0.0053 16.5 11.0 0.0053 16.5 11.0 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_172937.3_1 - 0.22 11.3 12.2 0.43 10.3 9.9 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Pentaxin PF00354.15 NM_025470.3_2 - 2e-72 242.8 0.0 2.6e-72 242.5 0.0 1.1 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 NM_025470.3_2 - 5.7e-06 26.4 0.0 7.7e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Cys_rich_FGFR PF00839.15 NM_009149.2_1 - 1.8e-203 658.8 121.5 2.4e-16 59.5 1.1 16.3 16 0 0 16 16 16 16 Cysteine rich repeat Spt20 PF12090.6 NM_009149.2_1 - 0.096 12.2 6.5 0.27 10.7 6.5 1.7 1 0 0 1 1 1 0 Spt20 family CRAL_TRIO_2 PF13716.4 NM_010269.3_1 - 1e-32 113.0 2.8 1.7e-32 112.2 2.8 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Macro PF01661.19 NM_010269.3_1 - 6.1e-29 100.3 0.0 1.2e-28 99.4 0.0 1.5 1 0 0 1 1 1 1 Macro domain CRAL_TRIO PF00650.18 NM_010269.3_1 - 0.00015 21.4 1.2 0.00026 20.6 1.2 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain Homeobox PF00046.27 NM_001294278.1_3 - 4.3e-23 80.8 4.4 6.8e-23 80.1 4.4 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_001294278.1_3 - 0.065 13.0 0.1 0.065 13.0 0.1 2.1 2 0 0 2 2 2 0 Homeobox KN domain TFIIE_beta PF02186.13 NM_001167921.1_2 - 3.7e-24 84.7 1.3 9.4e-24 83.4 0.2 2.2 2 0 0 2 2 2 1 TFIIE beta subunit core domain 7tm_4 PF13853.4 NM_001011804.1_1 - 2.5e-48 165.1 18.2 3.3e-48 164.7 18.2 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011804.1_1 - 2.8e-15 56.2 23.4 5.7e-14 51.9 23.4 3.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_001011804.1_1 - 0.9 9.0 4.0 2 7.9 0.3 2.9 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus FEZ PF07763.11 NM_001285949.1_1 - 1.8e-91 306.0 11.4 2.4e-91 305.6 11.4 1.1 1 0 0 1 1 1 1 FEZ-like protein DUF5102 PF17104.3 NM_001285949.1_1 - 3.4e-06 27.2 2.7 0.014 15.3 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF5102) fn3 PF00041.19 NM_018776.2_2 - 0.0016 18.6 0.0 0.0034 17.6 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_2 PF13639.4 NM_001316728.1_2 - 3.6e-14 52.6 4.7 9.1e-14 51.3 4.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.3 NM_001316728.1_2 - 8.4e-12 44.5 1.7 1.9e-11 43.3 0.6 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 NM_001316728.1_2 - 1.4e-09 37.5 4.5 3.2e-09 36.4 4.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001316728.1_2 - 1.2e-08 34.5 3.5 2.8e-08 33.4 3.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001316728.1_2 - 9e-08 31.8 2.8 2.3e-07 30.5 2.8 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.5 NM_001316728.1_2 - 1.6e-06 28.1 6.4 6.4e-06 26.2 6.4 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.4 NM_001316728.1_2 - 2.8e-06 27.0 3.1 5.7e-06 26.0 3.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001316728.1_2 - 1.3e-05 25.0 5.8 5.5e-05 23.0 0.4 3.1 3 0 0 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.4 NM_001316728.1_2 - 0.00043 19.9 4.2 0.00093 18.9 4.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 PA PF02225.20 NM_001316728.1_2 - 0.00097 19.1 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 PA domain zf-ANAPC11 PF12861.5 NM_001316728.1_2 - 0.0036 17.2 4.0 0.012 15.5 4.0 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.27 NM_001316728.1_2 - 0.047 13.5 3.7 0.12 12.1 3.7 1.8 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.5 NM_001316728.1_2 - 0.072 13.1 3.9 0.25 11.4 3.9 2.0 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.3 NM_001316728.1_2 - 0.12 11.9 2.9 0.26 10.8 2.9 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.3 NM_001316728.1_2 - 0.42 10.6 3.8 1.3 9.0 3.8 1.9 1 1 0 1 1 1 0 Zinc-finger zf-RING_4 PF14570.4 NM_001316728.1_2 - 0.42 10.2 5.2 1.2 8.8 5.2 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.9 NM_001316728.1_2 - 0.56 10.4 3.9 1.5 9.0 3.9 1.8 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.6 NM_001316728.1_2 - 1.3 9.2 5.6 6.3 6.9 5.6 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-LITAF-like PF10601.7 NM_025670.4_3 - 1.6e-20 73.0 16.5 1.6e-20 73.0 16.5 2.0 2 0 0 2 2 2 1 LITAF-like zinc ribbon domain NUDIX_4 PF14815.4 NM_001159581.1_3 - 1.7e-23 82.5 0.1 4.9e-23 81.1 0.1 1.8 1 0 0 1 1 1 1 NUDIX domain HhH-GPD PF00730.23 NM_001159581.1_3 - 7e-22 77.8 0.0 1.6e-21 76.6 0.0 1.7 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.21 NM_001159581.1_3 - 2.1e-09 36.7 0.2 3.6e-08 32.7 0.0 2.7 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.7 NM_001159581.1_3 - 0.00033 20.8 4.5 0.00081 19.5 4.5 1.7 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III PHF12_MRG_bd PF16737.3 NM_174852.3_2 - 1.9e-18 65.8 0.9 4.8e-18 64.4 0.9 1.8 1 0 0 1 1 1 1 PHD finger protein 12 MRG binding domain PHD PF00628.27 NM_174852.3_2 - 4.4e-16 58.4 27.7 3.7e-09 36.2 13.3 3.4 3 0 0 3 3 3 2 PHD-finger FHA PF00498.24 NM_174852.3_2 - 0.00058 20.0 0.0 0.0015 18.7 0.0 1.7 1 0 0 1 1 1 1 FHA domain C1_1 PF00130.20 NM_174852.3_2 - 0.007 16.1 15.8 0.014 15.1 1.6 2.9 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.4 NM_174852.3_2 - 0.13 11.7 0.1 0.13 11.7 0.1 4.5 6 0 0 6 6 6 0 PHD-finger Glyco_transf_10 PF00852.17 NM_001286422.1_1 - 8.1e-35 120.0 0.0 1.4e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 NM_001286422.1_1 - 4.1e-10 40.0 0.0 9.3e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal zn-ribbon_14 PF16503.3 NM_001286422.1_2 - 0.043 13.2 0.5 0.15 11.5 0.5 1.9 1 0 0 1 1 1 0 Zinc-ribbon CH PF00307.29 NM_001111016.1_2 - 1.4e-15 57.3 0.2 2.7e-15 56.4 0.2 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain AAA_22 PF13401.4 NM_001111016.1_2 - 3.4e-05 24.0 0.9 0.0017 18.5 0.2 3.2 2 1 0 2 2 2 1 AAA domain AAA PF00004.27 NM_001111016.1_2 - 0.00055 20.2 0.1 0.0037 17.5 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.4 NM_001111016.1_2 - 0.00067 19.6 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 NM_001111016.1_2 - 0.0013 19.1 0.0 0.0041 17.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 NM_001111016.1_2 - 0.0022 18.2 0.1 0.18 12.1 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain CAMSAP_CH PF11971.6 NM_001111016.1_2 - 0.0053 16.4 0.4 0.037 13.7 0.0 2.3 2 0 0 2 2 2 1 CAMSAP CH domain IstB_IS21 PF01695.15 NM_001111016.1_2 - 0.0059 16.3 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein PhoH PF02562.14 NM_001111016.1_2 - 0.015 14.6 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.18 NM_001111016.1_2 - 0.016 14.1 0.0 0.038 12.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.4 NM_001111016.1_2 - 0.039 14.1 0.0 0.081 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 NM_001111016.1_2 - 0.049 13.2 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.4 NM_001111016.1_2 - 0.062 13.5 0.2 0.17 12.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_5 PF07728.12 NM_001111016.1_2 - 0.091 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.4 NM_001111016.1_2 - 0.092 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Lon_2 PF13337.4 NM_001111016.1_2 - 0.15 10.4 0.0 0.24 9.8 0.0 1.1 1 0 0 1 1 1 0 Putative ATP-dependent Lon protease ResIII PF04851.13 NM_001111016.1_2 - 0.24 11.2 1.4 1.2 8.9 0.0 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2205 PF10224.7 NM_001111016.1_2 - 0.39 10.6 3.2 1.3 9.0 3.2 1.8 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) DUF4407 PF14362.4 NM_001111016.1_2 - 2.5 7.3 14.4 0.053 12.7 2.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) SlyX PF04102.10 NM_001111016.1_2 - 3 8.4 11.1 0.99 9.9 0.2 3.8 2 1 1 3 3 3 0 SlyX APG6 PF04111.10 NM_001111016.1_2 - 5.9 6.0 19.8 0.41 9.8 1.4 3.0 3 0 0 3 3 2 0 Autophagy protein Apg6 C2 PF00168.28 NM_027909.2_2 - 0.013 15.6 0.0 0.025 14.7 0.0 1.5 1 0 0 1 1 1 0 C2 domain PetN PF03742.12 NM_027909.2_2 - 0.11 12.3 0.9 0.29 10.9 0.9 1.7 1 0 0 1 1 1 0 PetN tRNA-synt_1d PF00750.17 NM_181406.3_1 - 2e-96 322.8 1.0 3.1e-96 322.2 1.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.13 NM_181406.3_1 - 5.9e-21 74.7 0.0 1.6e-20 73.3 0.0 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain EABR PF12180.6 NM_139064.2_2 - 8.7e-18 63.5 2.1 2.3e-17 62.1 2.1 1.8 1 0 0 1 1 1 1 TSG101 and ALIX binding domain of CEP55 CC2-LZ PF16516.3 NM_139064.2_2 - 8.4e-09 35.6 11.1 8.4e-09 35.6 11.1 4.2 2 2 2 4 4 4 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator QLQ PF08880.9 NM_139064.2_2 - 1.1 8.9 8.9 0.29 10.8 1.0 2.6 2 0 0 2 2 2 0 QLQ BST2 PF16716.3 NM_139064.2_2 - 3.7 8.1 33.3 0.22 12.0 3.4 4.7 2 2 1 4 4 4 0 Bone marrow stromal antigen 2 HSBP1 PF06825.10 NM_139064.2_2 - 6.2 6.7 7.5 13 5.7 0.0 3.2 3 1 0 3 3 3 0 Heat shock factor binding protein 1 GAS PF13851.4 NM_139064.2_2 - 6.6 5.9 42.1 0.88 8.8 4.6 3.8 1 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding BNR PF02012.18 NM_139064.2_3 - 0.035 14.0 0.6 0.14 12.1 0.1 2.4 2 0 0 2 2 2 0 BNR/Asp-box repeat Lectin_C PF00059.19 NM_001109750.1_1 - 2.6e-20 73.0 0.6 4.3e-20 72.3 0.6 1.4 1 0 0 1 1 1 1 Lectin C-type domain Ldl_recept_a PF00057.16 NM_001109750.1_1 - 8e-11 41.8 5.3 8e-11 41.8 5.3 3.0 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A UL45 PF05473.10 NM_001109750.1_1 - 0.0024 17.4 0.0 0.0053 16.3 0.0 1.5 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like RRM_1 PF00076.20 NM_207686.1_1 - 3.2e-65 215.8 0.2 1.3e-20 72.9 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_207686.1_1 - 8.5e-12 44.6 0.0 0.00057 19.4 0.0 3.3 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_207686.1_1 - 0.024 14.6 0.0 2 8.5 0.0 3.1 3 0 0 3 3 3 0 RNA recognition motif RRM_occluded PF16842.3 NM_207686.1_1 - 0.032 14.0 0.1 4.2 7.2 0.0 3.0 3 0 0 3 3 3 0 Occluded RNA-recognition motif BNR_2 PF13088.4 NM_001160163.1_1 - 5.9e-40 137.2 0.0 8e-40 136.7 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 NM_001160163.1_1 - 1.1e-05 24.7 0.0 1.5e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 NM_001160163.1_1 - 3.1e-05 23.2 0.9 0.39 10.8 0.2 2.8 2 0 0 2 2 2 2 BNR/Asp-box repeat CHB_HEX_C PF03174.11 NM_001160163.1_1 - 0.12 12.2 0.0 0.37 10.7 0.0 1.8 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain V1R PF03402.12 NM_011911.1_1 - 1.9e-162 539.0 23.9 2.2e-162 538.8 23.9 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_011911.1_1 - 0.00084 18.4 27.3 0.0013 17.8 27.3 1.3 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Gar1 PF04410.12 NM_001163564.1_1 - 2e-44 150.9 0.6 3.2e-44 150.3 0.6 1.2 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region NYD-SP28 PF14772.4 NM_001163564.1_1 - 0.37 10.8 3.1 0.6 10.1 3.1 1.2 1 0 0 1 1 1 0 Sperm tail SR-25 PF10500.7 NM_001163564.1_1 - 8.5 5.8 19.5 1.7 8.1 10.8 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein 7tm_4 PF13853.4 NM_001011824.1_1 - 1.2e-50 172.7 27.8 1.4e-50 172.5 27.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011824.1_1 - 2e-19 69.7 26.4 4e-19 68.8 26.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011824.1_1 - 5.2e-06 25.9 28.4 2.1e-05 23.9 28.4 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx fn3 PF00041.19 NM_001113386.1_2 - 2.6e-17 62.8 4.5 9.7e-07 28.9 0.2 4.6 5 0 0 5 5 5 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_001113386.1_2 - 8.1e-06 26.2 0.6 4.8e-05 23.7 0.3 2.4 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain IL6Ra-bind PF09240.8 NM_001113386.1_2 - 0.00021 21.5 0.6 0.12 12.7 0.0 3.2 3 0 0 3 3 3 2 Interleukin-6 receptor alpha chain, binding PhoD_N PF16655.3 NM_001113386.1_2 - 0.02 15.3 0.0 0.046 14.1 0.0 1.6 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain E1-E2_ATPase PF00122.18 NM_175025.4_2 - 3.4e-60 203.0 1.0 7.3e-60 201.9 1.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 NM_175025.4_2 - 2.2e-45 154.5 3.9 2.2e-45 154.5 3.9 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.24 NM_175025.4_2 - 3.3e-21 76.4 2.4 1.1e-20 74.8 2.4 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 NM_175025.4_2 - 1.6e-17 62.8 0.1 3.2e-17 61.8 0.1 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.4 NM_175025.4_2 - 3e-16 59.2 0.1 4.3e-15 55.4 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.10 NM_175025.4_2 - 0.00087 19.0 3.1 0.0017 18.0 3.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase 7tm_2 PF00002.22 NM_001083936.1_2 - 1.6e-90 302.5 13.0 2.1e-90 302.2 13.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_001083936.1_2 - 3.9e-19 68.6 2.9 8e-19 67.6 2.9 1.6 1 0 0 1 1 1 1 Hormone receptor domain Methyltransf_23 PF13489.4 NM_001110512.1_1 - 2e-13 50.4 0.0 3.3e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_001110512.1_1 - 2.1e-13 50.7 0.0 3.9e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001110512.1_1 - 1.6e-11 44.5 0.0 2.7e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_001110512.1_1 - 5.3e-11 43.0 0.0 8.8e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001110512.1_1 - 5.7e-06 26.1 0.0 8.6e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 NM_001110512.1_1 - 2.3e-05 23.7 0.0 4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CheR PF01739.16 NM_001110512.1_1 - 0.032 13.6 0.0 1.8 7.9 0.0 2.2 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain Tcp11 PF05794.11 NM_027952.3_1 - 4e-105 352.3 1.6 4e-105 352.3 1.6 1.4 2 0 0 2 2 2 1 T-complex protein 11 UBA_e1_thiolCys PF10585.7 NM_027952.3_1 - 0.75 9.5 0.0 0.75 9.5 0.0 2.6 3 0 0 3 3 3 0 Ubiquitin-activating enzyme active site CFC PF09443.8 NM_011562.2_1 - 1.2e-15 56.9 12.9 2.6e-15 55.8 12.9 1.6 1 0 0 1 1 1 1 Cripto_Frl-1_Cryptic (CFC) EGF PF00008.25 NM_011562.2_1 - 0.007 16.5 6.1 0.026 14.7 6.1 2.0 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.11 NM_011562.2_1 - 0.0085 16.3 8.0 0.0085 16.3 8.0 2.7 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.5 NM_011562.2_1 - 0.0092 16.5 5.2 0.033 14.7 5.2 2.0 1 0 0 1 1 1 1 Human growth factor-like EGF ICAT PF06384.9 NM_026963.5_1 - 1.4e-31 108.4 0.5 1.4e-31 108.4 0.5 2.0 2 0 0 2 2 2 1 Beta-catenin-interacting protein ICAT Dynamin_M PF01031.18 NM_026963.5_1 - 0.0017 17.5 1.7 0.0031 16.7 1.7 1.3 1 0 0 1 1 1 1 Dynamin central region CAMP_factor PF07373.9 NM_026963.5_1 - 0.0025 17.3 0.9 0.0038 16.7 0.9 1.2 1 0 0 1 1 1 1 CAMP factor (Cfa) Serine_rich PF08824.8 NM_026963.5_1 - 0.0088 15.9 1.6 0.016 15.1 1.6 1.4 1 0 0 1 1 1 1 Serine rich protein interaction domain GvpG PF05120.10 NM_026963.5_1 - 0.011 15.6 1.0 0.011 15.6 1.0 2.3 2 0 0 2 2 2 0 Gas vesicle protein G DUF3313 PF11769.6 NM_026963.5_1 - 0.025 14.4 0.1 0.04 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) Swi5 PF07061.9 NM_026963.5_1 - 0.087 12.8 2.0 0.19 11.7 2.0 1.5 1 0 0 1 1 1 0 Swi5 IncA PF04156.12 NM_026963.5_1 - 0.49 10.0 11.5 0.034 13.8 6.6 1.4 2 0 0 2 2 2 0 IncA protein DUF2408 PF10303.7 NM_026963.5_1 - 0.59 10.6 8.3 0.52 10.7 6.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) DUF342 PF03961.11 NM_026963.5_1 - 0.74 8.2 2.0 1.1 7.7 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) FlxA PF14282.4 NM_026963.5_1 - 0.74 9.7 9.1 0.76 9.7 7.2 1.9 1 1 1 2 2 2 0 FlxA-like protein dsrm PF00035.24 NM_033324.2_2 - 3.8e-20 72.2 2.1 2.4e-12 47.2 0.0 3.5 3 0 0 3 3 3 2 Double-stranded RNA binding motif WW PF00397.24 NM_033324.2_2 - 0.0029 17.4 0.0 0.0062 16.3 0.0 1.6 1 0 0 1 1 1 1 WW domain PA28_beta PF02252.16 NM_011190.3_1 - 3.6e-53 179.0 0.0 4.7e-53 178.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.16 NM_011190.3_1 - 6.8e-24 83.7 1.8 1.1e-23 83.1 0.3 2.0 2 0 0 2 2 2 1 Proteasome activator pa28 alpha subunit CBFD_NFYB_HMF PF00808.21 NM_001277095.1_2 - 0.00055 20.0 0.8 0.0019 18.3 0.5 2.0 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PI-PLC-X PF00388.17 NM_013880.3_2 - 7.2e-61 203.9 0.1 1.4e-60 203.0 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 NM_013880.3_2 - 5.5e-39 133.0 0.3 1.9e-38 131.3 0.3 2.0 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_12 PF16457.3 NM_013880.3_2 - 1.4e-21 77.3 0.7 3.1e-21 76.2 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain EF-hand_like PF09279.9 NM_013880.3_2 - 1.5e-16 60.6 0.0 2.9e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.28 NM_013880.3_2 - 4.5e-16 58.9 0.0 1e-15 57.8 0.0 1.6 1 0 0 1 1 1 1 C2 domain PH PF00169.27 NM_013880.3_2 - 3.7e-06 27.3 0.1 1.1e-05 25.7 0.1 1.8 1 0 0 1 1 1 1 PH domain Mcp5_PH PF12814.5 NM_013880.3_2 - 0.0027 17.7 0.0 0.0061 16.5 0.0 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology EF-hand_7 PF13499.4 NM_013880.3_2 - 0.02 15.2 0.0 0.071 13.5 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.30 NM_013880.3_2 - 0.057 12.9 0.1 1.4 8.6 0.0 2.9 2 0 0 2 2 2 0 EF hand Histone PF00125.22 NM_175666.2_2 - 1.1e-24 87.2 0.7 1.3e-24 87.0 0.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_175666.2_2 - 1.9e-06 27.9 0.8 3.1e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 NM_175666.2_2 - 0.0054 17.1 0.0 0.0098 16.2 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.3 NM_175666.2_2 - 0.011 15.7 0.1 0.013 15.4 0.1 1.1 1 0 0 1 1 1 0 YscO-like protein ABC_tran PF00005.25 NM_031884.2_1 - 1.2e-26 93.7 0.0 1.9e-26 93.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.22 NM_031884.2_1 - 1.9e-22 79.6 10.9 2.9e-22 79.0 10.9 1.3 1 0 0 1 1 1 1 ABC-2 type transporter AAA_21 PF13304.4 NM_031884.2_1 - 6.2e-07 29.4 0.1 0.013 15.2 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 NM_031884.2_1 - 2.5e-05 23.8 0.1 5.1e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.4 NM_031884.2_1 - 0.00061 20.2 0.0 0.0013 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.17 NM_031884.2_1 - 0.0026 17.1 0.1 0.23 10.8 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 NM_031884.2_1 - 0.0027 18.0 0.0 0.0049 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 NM_031884.2_1 - 0.0029 17.4 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 NACHT PF05729.10 NM_031884.2_1 - 0.0071 16.1 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.4 NM_031884.2_1 - 0.031 14.4 0.0 0.16 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.13 NM_031884.2_1 - 0.044 13.6 0.0 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.12 NM_031884.2_1 - 0.05 13.5 0.2 1.6 8.6 0.1 2.5 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) PIF1 PF05970.12 NM_031884.2_1 - 0.053 12.5 0.0 0.091 11.8 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase MobB PF03205.12 NM_031884.2_1 - 0.083 12.7 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.4 NM_031884.2_1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.23 NM_031884.2_1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase_2 PF01637.16 NM_031884.2_1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_19 PF13245.4 NM_031884.2_1 - 0.15 12.2 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.17 NM_031884.2_1 - 0.16 11.4 0.1 0.39 10.2 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.18 NM_031884.2_1 - 0.16 10.8 0.0 0.31 9.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.15 NM_031884.2_1 - 0.17 11.5 0.1 0.71 9.5 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein ArgK PF03308.14 NM_031884.2_1 - 0.19 10.6 0.0 0.39 9.5 0.0 1.4 1 0 0 1 1 1 0 ArgK protein Cluap1 PF10234.7 NM_029738.2_1 - 8.9e-118 392.4 12.8 1.3e-117 391.8 12.8 1.3 1 0 0 1 1 1 1 Clusterin-associated protein-1 Ndc80_HEC PF03801.11 NM_029738.2_1 - 0.034 13.6 0.1 0.2 11.1 0.0 2.1 1 1 1 2 2 2 0 HEC/Ndc80p family SseC PF04888.10 NM_029738.2_1 - 0.06 12.7 3.2 0.09 12.1 3.2 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family TFIIA PF03153.11 NM_029738.2_1 - 0.062 13.1 12.0 0.078 12.8 12.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.8 NM_029738.2_1 - 0.16 11.1 23.2 0.26 10.4 23.2 1.3 1 0 0 1 1 1 0 BUD22 RasGAP_C PF03836.13 NM_029738.2_1 - 0.32 11.0 10.5 0.89 9.6 10.4 1.8 1 1 0 1 1 1 0 RasGAP C-terminus Tweety PF04906.11 NM_029738.2_1 - 2.8 6.4 4.2 1.7 7.1 1.9 1.7 1 1 0 1 1 1 0 Tweety GPS PF01825.19 NM_029738.2_2 - 0.37 11.3 7.1 0.38 11.3 2.3 3.1 3 0 0 3 3 3 0 GPCR proteolysis site, GPS, motif 7tm_4 PF13853.4 NM_146424.1_1 - 2.3e-48 165.2 22.6 3e-48 164.8 22.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146424.1_1 - 5.9e-24 84.6 22.3 1.1e-23 83.7 22.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146424.1_1 - 0.00031 20.1 22.6 0.00046 19.5 22.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PRK PF00485.16 NM_011675.2_3 - 9e-50 169.0 0.1 1.2e-49 168.7 0.1 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.4 NM_011675.2_3 - 6.2e-06 26.6 0.0 1e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain CoaE PF01121.18 NM_011675.2_3 - 2.5e-05 23.9 0.1 4.4e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_17 PF13207.4 NM_011675.2_3 - 0.017 15.4 0.6 1.4 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 NM_011675.2_3 - 0.019 14.1 0.0 0.028 13.6 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin T2SSE PF00437.18 NM_011675.2_3 - 0.16 10.8 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein MutL_C PF08676.9 NM_001304475.1_2 - 3e-13 49.7 0.5 2.8e-12 46.5 0.5 2.3 1 1 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.17 NM_001304475.1_2 - 1.2e-11 44.2 0.0 1.7e-10 40.5 0.0 2.3 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.4 NM_001304475.1_2 - 9e-07 28.7 0.1 2.6e-06 27.2 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 NM_001304475.1_2 - 2.4e-06 28.0 0.0 6.6e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IL6Ra-bind PF09240.8 NM_133990.5_3 - 3.1e-25 88.3 1.3 3.1e-25 88.3 1.3 2.3 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.19 NM_133990.5_3 - 1.2e-05 25.4 1.5 0.074 13.3 0.0 3.3 3 0 0 3 3 3 2 Fibronectin type III domain EpoR_lig-bind PF09067.8 NM_133990.5_3 - 3.5e-05 23.8 0.6 9e-05 22.5 0.6 1.6 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding Tissue_fac PF01108.15 NM_133990.5_3 - 0.0041 16.8 8.0 0.87 9.3 0.4 3.5 3 0 0 3 3 3 3 Tissue factor EOS1 PF12326.6 NM_198607.1_1 - 0.21 11.4 0.1 0.24 11.2 0.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein Fer4_18 PF13746.4 NM_198607.1_1 - 0.23 11.5 1.6 0.4 10.8 1.6 1.3 1 0 0 1 1 1 0 4Fe-4S dicluster domain 4HBT_2 PF13279.4 NM_198607.1_2 - 7.7e-22 77.9 0.0 1.1e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.20 NM_198607.1_2 - 0.0013 18.9 0.3 0.0026 18.0 0.3 1.5 1 0 0 1 1 1 1 Thioesterase superfamily Mito_fiss_reg PF05308.9 NM_198607.1_3 - 0.26 11.2 14.5 0.4 10.6 14.5 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator zf-HC5HC2H PF13771.4 NM_172603.3_1 - 2e-18 66.3 3.5 2e-18 66.3 3.5 2.2 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 NM_172603.3_1 - 4.2e-06 26.7 4.7 4.2e-06 26.7 4.7 1.8 2 0 0 2 2 2 1 PHD-zinc-finger like domain C1_2 PF03107.14 NM_172603.3_1 - 0.11 12.8 3.1 1 9.6 0.8 2.7 2 0 0 2 2 2 0 C1 domain Zf_RING PF16744.3 NM_172603.3_1 - 0.19 11.7 2.8 2 8.4 0.4 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger hemP PF10636.7 NM_172603.3_2 - 0.092 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Hemin uptake protein hemP UCH PF00443.27 NM_001033291.2_2 - 1.5e-37 129.4 0.1 1.7e-32 112.8 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001033291.2_2 - 6.9e-20 71.7 0.0 1.3e-19 70.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Pkinase_Tyr PF07714.15 NM_007377.4_2 - 9.8e-62 208.4 0.0 1.3e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_007377.4_2 - 6.2e-32 110.9 0.0 1.1e-31 110.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain FAM199X PF15814.3 NM_146261.2_1 - 8.6e-201 665.7 24.0 1.1e-200 665.3 24.0 1.2 1 0 0 1 1 1 1 Protein family FAM199X zf-C2H2 PF00096.24 NM_011813.3_2 - 8.6e-33 110.8 73.6 1.5e-05 25.0 0.9 11.7 11 0 0 11 11 11 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_011813.3_2 - 7.5e-27 92.4 85.8 1.2e-07 31.7 0.4 13.1 14 1 0 14 14 12 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_011813.3_2 - 1.3e-22 78.4 90.4 0.00084 19.8 0.9 12.4 13 0 0 13 13 12 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_011813.3_2 - 4.3e-12 45.9 18.7 0.82 9.9 0.0 9.3 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_011813.3_2 - 0.0008 20.0 14.4 0.61 10.7 0.2 5.4 4 1 0 5 5 5 1 zinc-ribbon family zf-C2H2_6 PF13912.4 NM_011813.3_2 - 0.0016 18.2 77.0 0.02 14.7 2.5 10.5 13 0 0 13 13 12 6 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_011813.3_2 - 0.0047 16.5 49.1 0.28 10.9 4.9 9.3 9 0 0 9 9 9 4 zinc-finger C2H2-type zf-Di19 PF05605.10 NM_011813.3_2 - 0.022 14.9 32.3 0.93 9.7 2.0 6.8 7 0 0 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 NM_011813.3_2 - 0.072 13.4 51.5 1.5 9.2 1.1 10.0 11 0 0 11 11 10 0 Zinc-finger of C2H2 type GAGA PF09237.9 NM_011813.3_2 - 0.86 9.3 15.6 7.6 6.3 0.2 5.4 3 1 1 5 5 5 0 GAGA factor zf-C2H2_9 PF16293.3 NM_011813.3_2 - 2.1 8.1 11.0 71 3.2 0.1 5.8 7 0 0 7 7 7 0 C2H2 type zinc-finger (1 copy) VEGF_C PF14554.4 NM_001317041.1_2 - 7e-28 96.4 21.3 7e-28 96.4 21.3 2.2 2 0 0 2 2 2 1 VEGF heparin-binding domain PDGF PF00341.15 NM_001317041.1_2 - 8.8e-26 89.9 6.3 8.8e-26 89.9 6.3 2.3 3 0 0 3 3 3 1 PDGF/VEGF domain bZIP_1 PF00170.19 NM_001110853.2_3 - 4.7e-20 71.3 10.5 7.9e-20 70.6 10.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.15 NM_001110853.2_3 - 6.2e-18 63.9 2.3 1.1e-17 63.0 2.3 1.4 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.13 NM_001110853.2_3 - 1.1e-06 28.4 11.2 1.8e-06 27.8 11.2 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001110853.2_3 - 0.019 15.3 6.4 0.034 14.5 6.4 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor Tropomyosin_1 PF12718.5 NM_001033243.2_3 - 0.0024 17.9 2.4 0.0024 17.9 2.4 5.2 3 2 1 4 4 4 1 Tropomyosin like Seryl_tRNA_N PF02403.20 NM_001033243.2_3 - 0.015 15.3 9.7 0.015 15.3 9.7 3.7 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.10 NM_001033243.2_3 - 7.3 6.5 42.5 2.3 8.1 9.6 4.0 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein V1R PF03402.12 NM_134228.1_1 - 1.3e-29 103.5 18.9 2.1e-29 102.8 18.9 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_134228.1_1 - 2.3e-07 30.1 22.2 2.7e-07 29.9 22.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_134228.1_1 - 0.00012 21.3 22.5 0.00016 20.9 22.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2663 PF10864.6 NM_134228.1_1 - 1 9.6 6.2 1.5 9.1 0.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2663) SepA PF17080.3 NM_134228.1_1 - 3.7 7.7 10.5 7 6.9 0.3 3.2 3 1 0 3 3 3 0 Multidrug Resistance efflux pump FAD_binding_1 PF00667.18 NM_001082476.2_1 - 1.4e-44 152.2 0.0 1.9e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 NM_001082476.2_1 - 5.5e-30 104.3 0.0 8.5e-30 103.7 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 NM_001082476.2_1 - 1.1e-11 45.2 0.0 1.9e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain zf-RING_2 PF13639.4 NM_001082476.2_1 - 2.4e-07 30.8 9.6 2.4e-07 30.8 9.6 2.2 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_001082476.2_1 - 8.2e-07 28.8 7.7 8.2e-07 28.8 7.7 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 NM_001082476.2_1 - 5.6e-05 22.8 8.1 0.00016 21.4 8.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.4 NM_001082476.2_1 - 0.00027 20.5 5.8 0.0007 19.1 5.8 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.23 NM_001082476.2_1 - 0.00054 19.6 11.3 0.00058 19.6 8.3 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001082476.2_1 - 0.0039 17.0 10.6 0.015 15.2 10.6 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.3 NM_001082476.2_1 - 0.03 13.9 1.1 0.11 12.1 1.1 2.0 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.4 NM_001082476.2_1 - 0.088 12.6 8.0 0.67 9.7 8.5 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.4 NM_001082476.2_1 - 0.17 11.9 7.6 0.57 10.3 7.6 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 NM_001082476.2_1 - 1 9.1 9.9 4.2 7.2 9.9 2.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPD52 PF04201.13 NM_001291197.1_2 - 1.6e-64 216.3 5.5 3.3e-34 117.7 1.2 2.2 1 1 1 2 2 2 2 Tumour protein D52 family ERM PF00769.17 NM_001252250.1_2 - 4.3e-63 213.3 36.0 4.3e-63 213.3 36.0 2.9 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_M PF00373.16 NM_001252250.1_2 - 5.3e-26 91.2 0.9 5.3e-26 91.2 0.9 2.8 2 1 0 2 2 2 1 FERM central domain FERM_C PF09380.8 NM_001252250.1_2 - 6.8e-24 84.0 1.4 1.2e-23 83.2 0.0 2.2 3 0 0 3 3 3 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_001252250.1_2 - 7.8e-11 41.6 0.6 7.8e-11 41.6 0.6 2.5 3 0 0 3 3 3 1 FERM N-terminal domain CUT PF02376.13 NM_139226.3_1 - 5e-31 106.6 0.3 7.9e-31 105.9 0.3 1.3 1 0 0 1 1 1 1 CUT domain Homeobox PF00046.27 NM_139226.3_1 - 2.4e-09 36.7 1.2 4.6e-09 35.8 1.2 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_139226.3_1 - 0.00045 19.9 0.1 0.0013 18.5 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain DUF3915 PF13054.4 NM_139226.3_1 - 0.41 10.5 1.8 1.3 8.9 1.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) MnmE_helical PF12631.5 NM_032544.3_2 - 5.9e-45 153.8 0.0 7.4e-45 153.5 0.0 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.7 NM_032544.3_2 - 9.6e-35 119.2 0.0 1.5e-34 118.5 0.0 1.3 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.21 NM_032544.3_2 - 4.7e-19 68.4 0.0 7.9e-19 67.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 NM_032544.3_2 - 4.6e-06 26.7 0.1 0.00073 19.5 0.2 2.2 1 1 1 2 2 2 1 Dynamin family FeoB_N PF02421.16 NM_032544.3_2 - 3.2e-05 23.4 0.0 4.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.14 NM_032544.3_2 - 0.00063 19.6 0.0 0.25 11.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_28 PF13521.4 NM_032544.3_2 - 0.01 16.0 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 NM_032544.3_2 - 0.017 15.4 4.6 0.019 15.2 0.4 2.8 1 1 2 3 3 3 0 AAA ATPase domain AAA_18 PF13238.4 NM_032544.3_2 - 0.1 13.0 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Guanylate_cyc PF00211.18 NM_173029.3_1 - 4.1e-25 88.3 1.6 1.7e-12 47.2 0.1 2.6 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.4 NM_173029.3_1 - 1.7e-05 25.1 0.0 3.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 NM_173029.3_1 - 0.00023 21.3 0.0 0.00086 19.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain TPR_8 PF13181.4 NM_173029.3_1 - 0.00035 20.4 5.1 1 9.6 0.1 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF577 PF04510.10 NM_173029.3_1 - 0.011 15.6 0.3 0.058 13.2 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF577) TPR_12 PF13424.4 NM_173029.3_1 - 0.011 15.9 3.3 7.4 6.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA_19 PF13245.4 NM_173029.3_1 - 0.013 15.7 0.1 0.036 14.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain TPR_1 PF00515.26 NM_173029.3_1 - 0.63 9.8 5.4 0.8 9.5 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_173029.3_1 - 6.2 7.1 7.3 9.3 6.5 0.0 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat Ion_trans PF00520.29 NM_021275.4_3 - 9e-49 165.8 8.4 1.4e-48 165.2 8.4 1.3 1 0 0 1 1 1 1 Ion transport protein K_channel_TID PF07941.9 NM_021275.4_3 - 6.3e-39 132.2 19.2 1.6e-38 130.9 19.2 1.7 1 0 0 1 1 1 1 Potassium channel Kv1.4 tandem inactivation domain BTB_2 PF02214.20 NM_021275.4_3 - 1.7e-27 95.4 0.1 3.7e-27 94.4 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_021275.4_3 - 1.2e-12 47.5 5.4 1.2e-12 47.5 5.4 2.2 2 0 0 2 2 2 1 Ion channel Adaptin_N PF01602.18 NM_001163552.1_3 - 6.4e-87 292.2 0.1 8.4e-87 291.8 0.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 NM_001163552.1_3 - 1.2e-35 122.7 0.8 2e-34 118.8 0.0 2.9 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.8 NM_001163552.1_3 - 1.1e-26 93.0 0.1 2e-26 92.1 0.1 1.5 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.4 NM_001163552.1_3 - 3.6e-08 33.5 0.0 0.009 16.2 0.0 5.0 3 2 2 5 5 5 3 HEAT repeats HEAT PF02985.20 NM_001163552.1_3 - 2.8e-06 27.0 8.8 0.59 10.4 0.1 6.0 7 0 0 7 7 7 3 HEAT repeat RTP1_C1 PF10363.7 NM_001163552.1_3 - 0.038 14.0 0.2 4 7.5 0.0 4.0 4 1 1 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Peptidase_C48 PF02902.17 NM_001172071.1_3 - 3.8e-11 43.1 0.4 1.1e-10 41.6 0.4 1.7 1 1 1 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain Ion_trans PF00520.29 NM_008421.3_2 - 8.5e-44 149.5 13.6 1.2e-43 149.0 13.6 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_008421.3_2 - 7.8e-27 93.3 0.0 1.3e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_008421.3_2 - 3.3e-10 39.7 2.6 3.3e-10 39.7 2.6 2.4 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.3 NM_008421.3_2 - 0.03 14.3 0.0 0.054 13.5 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain Plant_zn_clust PF10533.7 NM_001080969.3_1 - 1.1 9.1 6.8 3.3 7.6 6.8 1.9 1 0 0 1 1 1 0 Plant zinc cluster domain Thg1 PF04446.10 NM_001080969.3_3 - 8.6e-50 167.9 0.2 1.3e-49 167.3 0.2 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.4 NM_001080969.3_3 - 1.7e-46 157.2 0.2 2.6e-46 156.6 0.2 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain Forkhead PF00250.16 NM_001034894.3_2 - 1.8e-23 82.5 0.0 3.8e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 Forkhead domain Spectrin PF00435.19 NM_001177667.1_2 - 0 1544.0 272.0 4.5e-30 104.1 6.9 23.1 23 0 0 23 23 23 22 Spectrin repeat EFhand_Ca_insen PF08726.8 NM_001177667.1_2 - 2.1e-28 98.1 1.0 1.7e-26 92.0 0.1 3.8 3 0 0 3 3 3 1 Ca2+ insensitive EF hand SH3_1 PF00018.26 NM_001177667.1_2 - 4.3e-15 54.9 0.0 9.5e-15 53.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain EF-hand_1 PF00036.30 NM_001177667.1_2 - 2.6e-13 48.3 0.3 5.2e-07 28.6 0.1 3.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 NM_001177667.1_2 - 3.6e-12 46.4 0.7 4.8e-10 39.6 0.0 4.3 2 1 1 3 3 2 1 EF-hand domain pair SH3_9 PF14604.4 NM_001177667.1_2 - 6.5e-11 41.8 0.0 1.3e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain EF-hand_6 PF13405.4 NM_001177667.1_2 - 1.4e-09 36.9 0.3 7.3e-05 22.3 0.2 4.9 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.4 NM_001177667.1_2 - 2.1e-08 33.7 0.0 0.0065 16.1 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain pair SH3_2 PF07653.15 NM_001177667.1_2 - 8.2e-07 28.5 0.0 1.8e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain EF-hand_5 PF13202.4 NM_001177667.1_2 - 1.8e-06 27.1 0.0 0.026 13.9 0.0 3.4 2 0 0 2 2 2 2 EF hand SH3_3 PF08239.9 NM_001177667.1_2 - 0.00043 20.4 0.0 0.0014 18.7 0.0 2.0 1 0 0 1 1 1 1 Bacterial SH3 domain GvpG PF05120.10 NM_001177667.1_2 - 0.0039 17.0 15.1 1.9 8.4 0.5 6.9 5 0 0 5 5 5 2 Gas vesicle protein G Vip3A_N PF12495.6 NM_001177667.1_2 - 0.0044 16.8 5.0 10 5.8 0.1 4.3 3 0 0 3 3 3 1 Vegetative insecticide protein 3A N terminal Peroxidase_2 PF01328.15 NM_001177667.1_2 - 0.008 15.2 0.7 0.68 8.9 0.2 2.6 2 0 0 2 2 2 1 Peroxidase, family 2 Tetrabrachion PF11401.6 NM_001177667.1_2 - 0.12 12.3 0.4 0.5 10.3 0.1 2.2 3 0 0 3 3 2 0 Tetrabrachion ER_lumen_recept PF00810.16 NM_133950.2_1 - 1.1e-56 191.6 9.9 1.8e-56 190.9 9.9 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.12 NM_133950.2_1 - 6 6.6 14.2 1.1 9.0 0.3 3.3 4 0 0 4 4 4 0 PQ loop repeat Ig_3 PF13927.4 NM_001293673.1_2 - 8.4e-21 74.2 2.2 4.3e-12 46.3 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_001293673.1_2 - 3.8e-15 55.6 0.2 1.2e-11 44.4 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001293673.1_2 - 3.3e-12 46.4 1.1 2e-05 24.7 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001293673.1_2 - 6.4e-09 35.7 1.4 0.0036 17.3 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_001293673.1_2 - 6.9e-05 22.8 5.1 0.36 10.9 0.0 3.6 2 2 1 3 3 3 2 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_001293673.1_2 - 0.0052 17.1 0.1 1.4 9.2 0.0 2.5 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain FBA PF04300.11 NM_001163706.1_1 - 4.8e-75 251.2 0.0 6.1e-75 250.9 0.0 1.1 1 0 0 1 1 1 1 F-box associated region F-box-like PF12937.5 NM_001163706.1_1 - 2.3e-09 36.9 3.7 4.9e-09 35.8 3.7 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_001163706.1_1 - 9.7e-07 28.4 4.2 2.2e-06 27.3 4.2 1.6 1 0 0 1 1 1 1 F-box domain zf-H2C2_2 PF13465.4 NM_027547.2_2 - 1.8e-65 214.5 114.6 3.9e-09 36.4 0.8 15.4 15 0 0 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_027547.2_2 - 8.4e-58 189.6 107.2 1.5e-05 25.0 0.6 15.3 15 0 0 15 15 15 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_027547.2_2 - 1.6e-51 168.4 105.7 0.00016 22.1 0.3 15.4 15 0 0 15 15 15 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_027547.2_2 - 4.2e-26 90.5 83.9 0.00052 20.1 0.4 14.9 15 0 0 15 15 15 9 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_027547.2_2 - 9.8e-25 85.9 90.0 0.00087 19.0 0.6 15.8 14 2 1 15 15 15 10 C2H2-type zinc finger zf-met PF12874.5 NM_027547.2_2 - 2.7e-19 68.8 85.7 0.0019 18.4 0.7 14.8 15 0 0 15 15 15 9 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_027547.2_2 - 3.8e-11 42.4 60.2 0.024 14.3 0.1 12.8 14 0 0 14 14 14 6 zinc-finger C2H2-type zf-Di19 PF05605.10 NM_027547.2_2 - 2.4e-09 37.2 78.2 0.0083 16.3 1.9 9.2 4 2 3 9 9 9 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.3 NM_027547.2_2 - 0.0001 22.4 57.9 0.00026 21.1 1.4 7.8 1 1 8 9 9 9 3 C2H2-type zinc ribbon DUF4428 PF14471.4 NM_027547.2_2 - 0.013 15.3 2.0 0.013 15.3 2.0 5.6 7 1 0 7 7 5 0 Domain of unknown function (DUF4428) zf-C2H2_9 PF16293.3 NM_027547.2_2 - 0.061 13.0 25.0 6.9 6.5 0.0 8.5 7 2 2 9 9 9 0 C2H2 type zinc-finger (1 copy) Rad50_zn_hook PF04423.12 NM_027547.2_2 - 0.096 12.4 8.4 13 5.6 0.1 4.1 3 0 0 3 3 3 0 Rad50 zinc hook motif BolA PF01722.16 NM_027547.2_2 - 0.1 12.8 18.5 1.4 9.1 0.1 6.6 4 3 1 5 5 5 0 BolA-like protein zinc_ribbon_15 PF17032.3 NM_027547.2_2 - 0.14 12.8 63.1 1.7 9.3 1.8 7.9 2 1 4 6 6 6 0 zinc-ribbon family GAGA PF09237.9 NM_027547.2_2 - 1.3 8.8 19.0 0.29 10.8 0.3 5.8 5 2 1 7 7 7 0 GAGA factor zf-C2H2_2 PF12756.5 NM_027547.2_2 - 1.4 9.1 82.4 3.2 8.0 2.7 12.2 1 1 9 12 12 12 0 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.13 NM_027547.2_2 - 4 7.3 54.9 0.66 9.8 0.1 10.3 9 3 2 11 11 10 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-FCS PF06467.12 NM_027547.2_2 - 4.1 7.3 47.3 0.93 9.4 0.1 9.8 11 1 0 11 11 11 0 MYM-type Zinc finger with FCS sequence motif Zn-ribbon_8 PF09723.8 NM_027547.2_2 - 6.7 6.8 70.9 0.048 13.7 1.6 10.3 5 2 6 12 12 12 0 Zinc ribbon domain Glyoxalase_4 PF13669.4 NM_028626.1_1 - 6.7e-18 64.8 0.0 9.1e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.23 NM_028626.1_1 - 1.1e-11 44.8 0.0 1.5e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.4 NM_028626.1_1 - 6e-06 26.4 0.0 8.1e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.5 NM_028626.1_1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 0 Glyoxalase-like domain Kinesin PF00225.21 NM_010626.3_2 - 1.1e-103 346.5 1.6 1.7e-102 342.7 0.0 2.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 NM_010626.3_2 - 2.7e-18 66.2 0.1 1.4e-17 63.9 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding Peptidase_A25 PF03418.12 NM_010626.3_2 - 1.9 7.2 7.3 3.3 6.4 7.3 1.3 1 0 0 1 1 1 0 Germination protease Peptidase_C101 PF16218.3 NM_001013792.2_1 - 8.1e-125 415.3 0.7 9.8e-125 415.0 0.7 1.1 1 0 0 1 1 1 1 Peptidase family C101 Peptidase_C65 PF10275.7 NM_001013792.2_1 - 6.8e-05 22.3 0.2 0.00015 21.2 0.2 1.6 1 1 0 1 1 1 1 Peptidase C65 Otubain 7tm_4 PF13853.4 NM_001011759.2_1 - 2.9e-55 187.8 18.6 3.6e-55 187.5 18.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011759.2_1 - 1e-22 80.6 20.0 2e-22 79.6 20.0 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011759.2_1 - 0.006 15.9 20.7 0.019 14.2 20.7 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Keratin_B2_2 PF13885.4 NM_001099311.2_1 - 3e-41 139.0 318.6 6e-11 42.0 67.7 5.9 1 1 4 5 5 5 5 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_001099311.2_1 - 1.5e-15 57.5 237.8 9e-08 32.1 64.1 4.3 1 1 3 4 4 4 4 Keratin, high sulfur B2 protein NeuB PF03102.12 NM_053179.3_1 - 2e-77 259.7 0.0 2.9e-77 259.2 0.0 1.2 1 0 0 1 1 1 1 NeuB family SAF PF08666.10 NM_053179.3_1 - 1.3e-05 25.6 0.1 2.3e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 SAF domain BAT2_N PF07001.9 NM_001159634.1_1 - 2.3e-65 220.6 9.6 2.3e-65 220.6 9.6 5.0 5 0 0 5 5 5 1 BAT2 N-terminus ABC_tran PF00005.25 NM_013790.2_2 - 4.4e-52 176.1 0.0 2.2e-30 105.8 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.21 NM_013790.2_2 - 2.7e-50 171.4 35.2 1.1e-33 116.9 12.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.17 NM_013790.2_2 - 1.9e-10 40.4 5.3 0.017 14.5 0.0 4.3 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 NM_013790.2_2 - 0.00084 18.9 2.1 0.51 10.0 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.21 NM_013790.2_2 - 0.0063 16.5 2.1 1 9.4 0.2 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.4 NM_013790.2_2 - 0.011 16.2 3.4 0.71 10.2 0.1 2.7 3 0 0 3 3 2 0 AAA domain Dynamin_N PF00350.21 NM_013790.2_2 - 0.011 15.6 1.5 0.13 12.2 0.0 2.5 2 0 0 2 2 2 0 Dynamin family DUF258 PF03193.14 NM_013790.2_2 - 0.012 15.4 1.0 0.39 10.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_21 PF13304.4 NM_013790.2_2 - 0.02 14.6 9.0 3.5 7.2 0.1 3.9 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.4 NM_013790.2_2 - 0.02 14.5 0.2 0.24 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.15 NM_013790.2_2 - 0.059 13.0 0.0 3.1 7.4 0.0 2.8 2 0 0 2 2 2 0 IstB-like ATP binding protein NB-ARC PF00931.20 NM_013790.2_2 - 0.075 11.9 0.2 2.4 7.0 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain DUF87 PF01935.15 NM_013790.2_2 - 0.1 12.5 3.6 2.6 7.9 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_18 PF13238.4 NM_013790.2_2 - 0.13 12.6 0.1 16 5.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain TsaE PF02367.15 NM_013790.2_2 - 0.15 12.0 0.6 0.34 10.8 0.1 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.10 NM_013790.2_2 - 0.16 11.1 0.6 6.2 5.9 0.1 2.6 3 0 0 3 3 3 0 Zeta toxin cobW PF02492.17 NM_013790.2_2 - 0.6 9.5 3.2 0.31 10.5 0.2 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.4 NM_013790.2_2 - 3.1 8.0 4.6 30 4.8 0.3 3.0 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.23 NM_134062.2_1 - 1.8e-73 247.1 0.0 2.6e-73 246.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.5 NM_134062.2_1 - 3.6e-51 171.5 2.4 9.2e-15 54.9 0.1 5.1 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_134062.2_1 - 2.4e-40 135.8 11.2 1.7e-07 31.2 0.4 7.6 2 1 5 8 8 7 7 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_134062.2_1 - 3.1e-38 129.5 6.1 1.6e-08 34.7 0.0 7.2 2 2 4 7 7 7 7 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.15 NM_134062.2_1 - 1.6e-35 122.5 0.0 2.7e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.28 NM_134062.2_1 - 2.8e-35 119.1 8.5 1.1e-05 25.5 0.0 8.8 9 0 0 9 9 9 6 Ankyrin repeat Ank_3 PF13606.4 NM_134062.2_1 - 6.4e-35 115.1 10.2 0.00022 21.3 0.1 9.1 8 0 0 8 8 8 7 Ankyrin repeat Death PF00531.20 NM_134062.2_1 - 1.5e-21 76.2 0.2 1.3e-20 73.2 0.0 2.8 3 1 0 3 3 3 1 Death domain COR PF16095.3 NM_134062.2_1 - 2.4e-07 30.6 0.0 6.1e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Kdo PF06293.12 NM_134062.2_1 - 2.2e-06 27.1 0.0 4.6e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 NM_134062.2_1 - 0.00012 21.6 0.0 0.00023 20.7 0.0 1.3 1 0 0 1 1 1 1 RIO1 family AAA_29 PF13555.4 NM_134062.2_1 - 0.02 14.5 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 NM_134062.2_1 - 0.047 14.1 0.1 0.14 12.6 0.1 1.7 1 0 0 1 1 1 0 ABC transporter APH PF01636.21 NM_134062.2_1 - 0.049 13.4 0.0 0.25 11.1 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family AAA_23 PF13476.4 NM_134062.2_1 - 0.076 13.4 0.1 0.4 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Choline_kinase PF01633.18 NM_134062.2_1 - 0.079 12.4 0.0 0.2 11.1 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Spore_III_AB PF09548.8 NM_134062.2_1 - 0.099 12.6 0.0 2.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DUF258 PF03193.14 NM_134062.2_1 - 0.18 11.6 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 TMEM52 PF14979.4 NM_001101640.1_1 - 2.3e-06 27.5 4.9 7.1e-06 25.9 3.0 2.3 2 0 0 2 2 2 1 Transmembrane 52 P66_CC PF16563.3 NM_001113346.1_2 - 9.3e-20 69.8 11.3 1.9e-19 68.9 11.3 1.5 1 0 0 1 1 1 1 Coiled-coil and interaction region of P66A and P66B with MBD2 GATA PF00320.25 NM_001113346.1_2 - 0.00016 21.1 6.6 0.00041 19.8 6.6 1.8 1 0 0 1 1 1 1 GATA zinc finger DUF3752 PF12572.6 NM_026177.3_1 - 1.4e-25 90.4 15.8 1.4e-25 90.4 15.8 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) BTB PF00651.29 NM_001085551.1_2 - 5.4e-12 45.8 0.0 3.1e-10 40.1 0.0 3.2 1 1 2 3 3 3 1 BTB/POZ domain Calx-beta PF03160.12 NM_148946.2_1 - 2.7e-63 210.3 0.5 1.7e-31 108.2 0.0 2.4 2 0 0 2 2 2 2 Calx-beta domain Na_Ca_ex PF01699.22 NM_148946.2_1 - 6.1e-57 191.7 32.2 4.5e-32 111.0 14.7 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.3 NM_148946.2_1 - 4.9e-47 159.4 0.0 7.5e-47 158.8 0.0 1.3 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain Ion_trans PF00520.29 NM_008227.1_3 - 2.4e-22 79.3 11.5 2.4e-22 79.3 11.5 1.7 2 0 0 2 2 2 1 Ion transport protein Ion_trans_N PF08412.8 NM_008227.1_3 - 1e-19 69.7 0.0 1.9e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.27 NM_008227.1_3 - 1e-15 57.4 0.0 2.1e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 NM_008227.1_3 - 0.0023 17.8 0.1 0.0023 17.8 0.1 2.2 2 0 0 2 2 2 1 Ion channel LUC7 PF03194.13 NM_025881.3_2 - 3.3e-82 275.7 15.5 5.3e-82 275.0 15.5 1.3 1 0 0 1 1 1 1 LUC7 N_terminus TSC22 PF01166.16 NM_025881.3_2 - 0.92 9.7 4.0 13 6.0 0.1 2.7 2 1 0 2 2 2 0 TSC-22/dip/bun family DUF972 PF06156.11 NM_025881.3_2 - 6.1 7.4 9.3 1.7 9.2 2.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF972) 7tm_4 PF13853.4 NM_146373.1_1 - 1e-44 153.3 22.4 1.2e-44 153.0 22.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146373.1_1 - 4.3e-19 68.7 21.1 1.2e-18 67.2 21.1 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_146373.1_1 - 5.9 6.4 10.9 0.51 9.8 0.1 2.9 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus PH PF00169.27 NM_031256.3_2 - 2.3e-12 47.2 0.0 4.1e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_031256.3_2 - 4.8e-06 26.8 0.2 1.8e-05 25.0 0.2 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 NM_031256.3_2 - 0.00014 21.9 0.0 0.00023 21.2 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain HLH PF00010.24 NM_133917.3_1 - 4e-08 33.0 1.6 1.1e-07 31.6 1.6 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ZapB PF06005.10 NM_133917.3_1 - 0.043 14.1 1.0 0.088 13.1 1.0 1.4 1 0 0 1 1 1 0 Cell division protein ZapB Seryl_tRNA_N PF02403.20 NM_133917.3_1 - 0.073 13.2 3.0 0.13 12.3 3.0 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF724 PF05266.12 NM_133917.3_1 - 0.092 12.4 3.6 0.15 11.7 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4416 PF14385.4 NM_133917.3_1 - 0.16 11.8 0.1 0.27 11.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4416) RPW8 PF05659.9 NM_133917.3_1 - 0.16 11.6 1.6 0.24 10.9 0.7 1.6 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF342 PF03961.11 NM_133917.3_1 - 0.68 8.3 2.7 1 7.8 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Troponin PF00992.18 NM_133917.3_1 - 0.79 9.9 4.1 1.3 9.2 4.1 1.2 1 0 0 1 1 1 0 Troponin Nod_GRP PF07806.9 NM_026865.2_3 - 0.56 10.0 4.7 1.4 8.7 4.7 1.6 1 0 0 1 1 1 0 Nodule-specific GRP repeat Abhydrolase_3 PF07859.11 NM_001126316.1_3 - 5.8e-32 111.1 0.0 7.6e-20 71.5 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_001126316.1_3 - 0.043 13.2 0.0 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family QCR10 PF09796.7 NM_001126316.1_3 - 0.087 12.8 0.0 0.087 12.8 0.0 2.0 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) DUF4131 PF13567.4 NM_001126316.1_3 - 0.45 10.0 3.2 5.9 6.3 4.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) 7tm_4 PF13853.4 NM_146868.2_2 - 2.5e-46 158.6 21.7 3.1e-46 158.2 21.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146868.2_2 - 9.9e-18 64.2 30.0 3.4e-17 62.4 30.0 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Phage_holin_3_2 PF04550.10 NM_146868.2_2 - 0.24 11.7 2.6 2 8.7 1.3 2.2 2 0 0 2 2 2 0 Phage holin family 2 BRI3BP PF14965.4 NM_134142.1_2 - 4.3e-52 176.1 9.0 4.3e-52 176.1 9.0 1.6 2 0 0 2 2 2 1 Negative regulator of p53/TP53 NfeD PF01957.16 NM_134142.1_2 - 0.44 10.8 9.3 0.21 11.9 0.9 2.7 1 1 2 3 3 3 0 NfeD-like C-terminal, partner-binding Aminotran_4 PF01063.17 NM_001243053.1_1 - 1.8e-30 106.4 0.0 2.5e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV NMU PF02070.13 NM_001311788.1_3 - 0.031 14.0 1.5 0.031 14.0 1.5 2.3 2 0 0 2 2 2 0 Neuromedin U TEA PF01285.16 NM_011566.4_2 - 1.8e-26 93.1 0.2 3.7e-26 92.1 0.1 1.4 2 0 0 2 2 2 1 TEA/ATTS domain family 7tm_4 PF13853.4 NM_146913.1_1 - 5e-49 167.4 22.1 6e-49 167.1 22.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146913.1_1 - 9.6e-21 74.1 24.6 2.1e-20 72.9 24.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UPF0197 PF05251.10 NM_146913.1_1 - 0.059 13.3 0.1 0.059 13.3 0.1 3.5 4 1 0 4 4 4 0 Uncharacterised protein family (UPF0197) Myotub-related PF06602.12 NM_016985.2_3 - 6.1e-148 492.2 0.1 7.8e-148 491.8 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.18 NM_016985.2_3 - 1.6e-08 34.3 0.0 2.7e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 GRAM domain 3-PAP PF12578.6 NM_016985.2_3 - 0.0047 16.5 0.1 0.0096 15.5 0.1 1.5 1 0 0 1 1 1 1 Myotubularin-associated protein Myb_CC_LHEQLE PF14379.4 NM_016985.2_3 - 0.0067 16.0 2.6 0.13 11.8 0.5 2.4 2 0 0 2 2 2 1 MYB-CC type transfactor, LHEQLE motif Y_phosphatase PF00102.25 NM_016985.2_3 - 0.043 13.2 0.0 0.078 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 NM_016985.2_3 - 0.069 13.0 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family HTH_IclR PF09339.8 NM_001039120.2_1 - 0.0011 18.5 2.0 14 5.5 0.0 4.1 1 1 3 4 4 4 3 IclR helix-turn-helix domain XPC-binding PF09280.9 NM_001039120.2_1 - 0.15 11.7 4.9 0.45 10.2 4.5 2.0 1 1 0 1 1 1 0 XPC-binding domain GluR_Homer-bdg PF10606.7 NM_001039120.2_2 - 2 8.5 8.3 29 4.8 0.9 3.6 2 1 1 3 3 3 0 Homer-binding domain of metabotropic glutamate receptor Defensin_beta_2 PF13841.4 NM_001039120.2_3 - 8.2e-08 32.5 13.8 1.2e-07 32.0 13.8 1.2 1 0 0 1 1 1 1 Beta defensin 7tm_1 PF00001.19 NM_001010839.1_1 - 6.1e-56 189.5 14.5 7.5e-56 189.2 14.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001010839.1_1 - 2.7e-08 33.4 17.4 3.5e-08 33.0 17.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001010839.1_1 - 5.8e-05 22.4 13.0 5.8e-05 22.4 13.0 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 NM_001010839.1_1 - 0.00018 21.2 12.7 0.0032 17.1 12.7 2.5 1 1 0 1 1 1 1 Olfactory receptor Ninjurin PF04923.10 NM_001010839.1_1 - 0.1 12.4 1.1 0.73 9.7 0.4 2.3 1 1 0 2 2 2 0 Ninjurin Thiolase_N PF00108.21 NM_009338.3_3 - 6.2e-96 320.6 2.0 9e-96 320.1 2.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 NM_009338.3_3 - 6.1e-50 167.9 1.0 1.3e-49 166.8 1.0 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 NM_009338.3_3 - 5e-05 22.9 3.9 0.015 14.8 2.1 3.1 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.8 NM_009338.3_3 - 0.00021 21.3 0.1 0.0045 17.0 0.1 2.7 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.8 NM_009338.3_3 - 0.06 13.1 0.3 8.9 6.1 0.0 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Dodecin PF07311.10 NM_009338.3_3 - 0.07 13.2 0.4 0.16 12.1 0.4 1.5 1 0 0 1 1 1 0 Dodecin UCH PF00443.27 NM_024258.2_1 - 6.9e-52 176.4 5.0 6.9e-52 176.4 5.0 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 NM_024258.2_1 - 7.9e-21 74.0 9.2 7.9e-21 74.0 9.2 2.2 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 NM_024258.2_1 - 4.7e-17 62.4 13.0 2.3e-15 56.9 13.0 3.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RbpA PF13397.4 NM_024258.2_1 - 0.05 14.1 0.3 0.22 12.0 0.3 2.1 1 0 0 1 1 1 0 RNA polymerase-binding protein BRCT_assoc PF12820.5 NM_024258.2_1 - 0.05 13.3 8.5 0.011 15.4 3.7 2.5 3 0 0 3 3 3 0 Serine-rich domain associated with BRCT zinc_ribbon_10 PF10058.7 NM_024258.2_1 - 0.67 9.6 7.0 0.083 12.5 0.3 2.9 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein RasGAP PF00616.17 NM_024258.2_1 - 6.3 6.3 17.7 2.1 7.8 0.5 3.5 3 0 0 3 3 3 0 GTPase-activator protein for Ras-like GTPase PRF PF06875.9 NM_001310038.2_1 - 1.9e-06 27.3 0.0 2.7e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Plethodontid receptivity factor PRF CNTF PF01110.15 NM_001310038.2_1 - 0.00071 18.9 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 Ciliary neurotrophic factor PAX PF00292.16 NM_001244202.2_2 - 3.1e-71 237.0 0.8 5.4e-71 236.2 0.8 1.4 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 NM_001244202.2_2 - 2e-22 78.6 4.5 4.3e-22 77.6 4.5 1.6 1 0 0 1 1 1 1 Homeobox domain HTH_23 PF13384.4 NM_001244202.2_2 - 0.007 16.0 0.2 0.034 13.8 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.5 NM_001244202.2_2 - 0.017 14.6 0.0 0.052 13.0 0.0 1.8 1 0 0 1 1 1 0 InsA C-terminal domain Keratin_B2_2 PF13885.4 NM_001024709.3_2 - 4e-23 81.0 264.6 1.4e-07 31.2 67.9 6.3 1 1 5 6 6 6 6 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_001024709.3_2 - 0.00059 19.7 192.1 0.039 13.8 81.7 4.1 1 1 2 3 3 3 2 Keratin, high sulfur B2 protein zf-H2C2_2 PF13465.4 NM_001309216.1_2 - 2.5e-150 482.7 158.1 2.6e-10 40.1 0.2 20.3 20 0 0 20 20 20 20 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001309216.1_2 - 3.5e-77 250.6 184.9 1.4e-06 28.3 2.2 19.4 19 0 0 19 19 19 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001309216.1_2 - 4.8e-45 148.2 168.0 0.0032 18.0 0.9 19.5 19 0 0 19 19 19 17 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001309216.1_2 - 1.4e-30 104.5 135.6 0.0031 17.3 1.1 18.8 19 0 0 19 19 19 16 C2H2-type zinc finger KRAB PF01352.25 NM_001309216.1_2 - 3.3e-20 71.3 0.2 5e-20 70.8 0.2 1.3 1 0 0 1 1 1 1 KRAB box DUF3268 PF11672.6 NM_001309216.1_2 - 3.9e-16 59.3 65.9 0.034 14.3 1.2 9.2 9 0 0 9 9 9 8 zinc-finger-containing domain Zn-ribbon_8 PF09723.8 NM_001309216.1_2 - 1.1e-12 47.8 96.6 0.021 14.8 2.8 12.5 3 2 14 17 17 17 14 Zinc ribbon domain GATA PF00320.25 NM_001309216.1_2 - 4.9e-09 35.5 72.9 1.7 8.2 0.1 16.4 17 0 0 17 17 16 3 GATA zinc finger zf-C2H2_11 PF16622.3 NM_001309216.1_2 - 3e-08 33.2 91.6 0.13 11.9 0.2 17.4 18 0 0 18 18 18 6 zinc-finger C2H2-type zf-trcl PF13451.4 NM_001309216.1_2 - 2.5e-07 30.3 66.8 3.8 7.4 1.8 16.4 13 4 1 15 15 15 2 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 NM_001309216.1_2 - 3.5e-05 24.3 74.4 0.95 10.1 2.0 9.3 1 1 11 12 12 12 8 zinc-ribbon family XPA_N PF01286.16 NM_001309216.1_2 - 9.4e-05 22.2 64.8 8.1 6.5 0.1 16.8 17 0 0 17 17 17 1 XPA protein N-terminal C1_4 PF07975.10 NM_001309216.1_2 - 0.00023 21.2 96.3 0.33 11.1 4.2 12.4 2 2 10 14 14 14 6 TFIIH C1-like domain SprT-like PF10263.7 NM_001309216.1_2 - 0.00074 19.2 97.7 0.87 9.3 9.6 9.3 1 1 9 10 10 10 7 SprT-like family BHD_1 PF10403.7 NM_001309216.1_2 - 0.019 14.6 16.6 13 5.6 0.0 8.4 7 2 3 10 10 10 0 Rad4 beta-hairpin domain 1 BDHCT_assoc PF16204.3 NM_001309216.1_2 - 0.02 14.4 2.4 7.8 6.0 0.0 4.3 3 3 3 6 6 6 0 BDHCT-box associated domain on Bloom syndrome protein ZZ PF00569.15 NM_001309216.1_2 - 0.14 11.9 94.1 2.7 7.8 0.2 17.3 18 0 0 18 18 18 0 Zinc finger, ZZ type zinc_ribbon_9 PF14369.4 NM_001309216.1_2 - 0.48 10.6 59.0 26 5.0 0.1 16.8 17 2 1 18 18 18 0 zinc-ribbon zf-C2HE PF16278.3 NM_001309216.1_2 - 9.1 6.7 110.2 11 6.5 1.2 17.0 2 2 12 14 14 14 0 C2HE / C2H2 / C2HC zinc-binding finger NCD1 PF04904.11 NM_001309216.1_3 - 1.6e-09 37.5 13.2 11 6.0 0.0 9.3 5 4 4 9 9 9 6 NAB conserved region 1 (NCD1) zf-C2H2 PF00096.24 NM_001309216.1_3 - 0.0066 16.7 9.8 0.079 13.3 4.0 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type DUF2108 PF09881.7 NM_001309216.1_3 - 0.082 12.7 0.3 0.3 11.0 0.3 2.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2108) Baculo_LEF-11 PF06385.10 NM_001309216.1_3 - 1.1 9.7 44.6 0.85 10.0 0.9 9.2 3 3 8 11 11 11 0 Baculovirus LEF-11 protein zf-C2H2_4 PF13894.4 NM_001309216.1_3 - 3.2 8.7 9.0 10 7.1 2.9 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_001309216.1_3 - 3.4 8.2 14.4 7.5 7.1 3.7 3.8 3 0 0 3 3 3 0 Zinc-finger double domain FANCI_S4 PF14678.4 NM_145946.2_2 - 2.5e-90 301.9 1.3 2.5e-90 301.9 1.3 2.5 2 1 0 2 2 2 1 FANCI solenoid 4 FANCI_HD2 PF14680.4 NM_145946.2_2 - 2.4e-83 278.8 5.7 2.4e-83 278.8 5.7 2.2 2 0 0 2 2 2 1 FANCI helical domain 2 FANCI_S3 PF14677.4 NM_145946.2_2 - 8.7e-78 260.8 3.8 8.7e-78 260.8 3.8 4.7 5 0 0 5 5 5 1 FANCI solenoid 3 FANCI_S1 PF14675.4 NM_145946.2_2 - 7.1e-76 254.4 1.0 2.9e-75 252.4 0.2 2.5 2 0 0 2 2 2 1 FANCI solenoid 1 FANCI_S2 PF14676.4 NM_145946.2_2 - 1.8e-60 203.8 1.3 1.8e-60 203.8 1.3 3.4 2 1 0 3 3 3 1 FANCI solenoid 2 FANCI_HD1 PF14679.4 NM_145946.2_2 - 4e-35 119.5 0.3 2.3e-34 117.1 0.3 2.5 1 0 0 1 1 1 1 FANCI helical domain 1 FANCI_S1-cap PF14674.4 NM_145946.2_2 - 9.7e-24 83.1 5.1 2.9e-23 81.6 3.2 2.9 2 0 0 2 2 2 1 FANCI solenoid 1 cap Mak16 PF04874.12 NM_145946.2_2 - 3.7 8.1 5.4 75 3.9 0.0 4.1 4 0 0 4 4 4 0 Mak16 protein C-terminal region GspH PF12019.6 NM_001190718.1_2 - 0.031 14.6 0.1 0.055 13.8 0.1 1.3 1 0 0 1 1 1 0 Type II transport protein GspH WD40 PF00400.30 NM_001190718.1_3 - 1.4e-05 25.6 2.4 0.0092 16.7 0.8 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat Ribosomal_L4 PF00573.20 NM_024212.4_3 - 9.7e-42 142.7 0.1 2.1e-41 141.6 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.4 NM_024212.4_3 - 4.1e-31 106.7 9.0 1.1e-30 105.3 9.0 1.8 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain PDZ PF00595.22 NM_015823.3_1 - 1.9e-59 197.9 10.0 5.8e-15 55.3 0.0 5.8 6 0 0 6 6 6 5 PDZ domain (Also known as DHR or GLGF) MAGI_u1 PF16663.3 NM_015823.3_1 - 1.9e-27 94.9 2.9 5.8e-27 93.3 2.9 1.9 1 0 0 1 1 1 1 Unstructured region on MAGI PDZ_2 PF13180.4 NM_015823.3_1 - 6.2e-25 87.2 0.2 7e-05 22.9 0.0 5.4 5 0 0 5 5 5 5 PDZ domain WW PF00397.24 NM_015823.3_1 - 2.9e-15 55.8 8.0 1.4e-09 37.6 0.3 2.9 3 0 0 3 3 3 2 WW domain MAGI_u5 PF16666.3 NM_015823.3_1 - 2.1e-13 50.5 6.4 2.1e-13 50.5 6.4 6.0 5 1 0 5 5 5 1 Unstructured region on MAGI Guanylate_kin PF00625.19 NM_015823.3_1 - 1e-09 38.2 0.0 2.4e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.4 NM_015823.3_1 - 4.3e-05 23.3 2.2 3.7 7.5 0.0 4.6 5 0 0 5 5 5 2 Tricorn protease PDZ domain DUF3915 PF13054.4 NM_015823.3_2 - 2.7 7.9 12.6 5 7.0 12.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 NM_015823.3_3 - 0.32 10.8 12.3 0.84 9.5 12.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Olfactory_mark PF06554.10 NM_011010.2_3 - 1.1e-76 255.6 0.4 1.7e-76 255.0 0.4 1.3 1 0 0 1 1 1 1 Olfactory marker protein C1q PF00386.19 NM_009777.2_1 - 2.2e-32 111.8 0.1 2.7e-32 111.5 0.1 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 NM_009777.2_1 - 1.1e-15 57.0 54.4 3.6e-09 36.1 20.4 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) LIM PF00412.20 NM_001289618.1_2 - 6e-31 106.3 29.2 1.2e-14 54.1 5.0 3.7 4 0 0 4 4 4 3 LIM domain zf-dskA_traR PF01258.15 NM_001289618.1_2 - 0.022 14.6 1.9 0.022 14.6 1.9 5.1 4 1 1 5 5 5 0 Prokaryotic dksA/traR C4-type zinc finger PRY PF13765.4 NM_001289615.1_2 - 6.4e-24 83.2 0.7 1.3e-23 82.2 0.7 1.6 1 0 0 1 1 1 1 SPRY-associated domain V-set PF07686.15 NM_001289615.1_2 - 6.1e-14 52.0 0.0 1.6e-13 50.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain SPRY PF00622.26 NM_001289615.1_2 - 4.3e-13 49.3 0.0 9.2e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 SPRY domain I-set PF07679.14 NM_001289615.1_2 - 3.3e-06 27.0 0.0 0.094 12.7 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001289615.1_2 - 1.9e-05 25.0 0.0 0.0061 17.0 0.0 3.0 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 NM_001289615.1_2 - 9.1e-05 22.6 0.1 0.0054 16.9 0.0 3.4 3 1 0 3 3 3 1 Immunoglobulin domain C2-set_2 PF08205.10 NM_001289615.1_2 - 0.0054 16.7 0.1 0.016 15.1 0.0 1.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 NM_001289615.1_2 - 0.035 14.1 1.1 0.39 10.8 0.1 2.9 2 1 0 2 2 2 0 Immunoglobulin domain Amnionless PF14828.4 NM_033603.3_3 - 2.5e-140 468.2 0.0 2.8e-140 468.0 0.0 1.0 1 0 0 1 1 1 1 Amnionless VWC PF00093.16 NM_033603.3_3 - 6.2 7.1 8.6 13 6.1 8.6 1.5 1 0 0 1 1 1 0 von Willebrand factor type C domain Tmemb_161AB PF10268.7 NM_001293797.1_2 - 6.7e-159 529.4 3.6 8.3e-159 529.1 3.6 1.0 1 0 0 1 1 1 1 Predicted transmembrane protein 161AB MAGE PF01454.17 NM_010882.3_3 - 3.1e-18 66.1 0.0 3.2e-15 56.3 0.0 2.2 1 1 0 1 1 1 1 MAGE family SHIPPO-rpt PF07004.10 NM_029604.3_3 - 5.1e-05 23.9 5.8 0.0046 17.7 0.7 3.8 3 1 0 3 3 3 2 Sperm-tail PG-rich repeat zf-H2C2_5 PF13909.4 NM_178267.3_2 - 2.3e-25 87.9 86.8 5.6e-06 25.9 0.2 11.2 11 0 0 11 11 11 9 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 NM_178267.3_2 - 5.3e-12 45.4 123.2 0.0009 19.4 0.2 14.1 14 0 0 14 14 14 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_178267.3_2 - 4.4e-08 33.1 125.6 5e-05 23.4 3.0 16.2 17 1 0 17 17 17 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_178267.3_2 - 3.8e-05 24.0 121.0 0.0056 17.3 0.3 15.3 14 0 0 14 14 14 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_178267.3_2 - 0.0019 18.0 0.2 0.0019 18.0 0.2 7.9 10 1 0 10 10 10 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_178267.3_2 - 1.5 9.1 0.0 0.13 12.5 0.9 8.0 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding DHO_dh PF01180.19 NM_020046.3_2 - 3.9e-115 384.0 0.0 4.8e-115 383.7 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Trp_syntA PF00290.18 NM_020046.3_2 - 0.036 12.8 0.0 0.054 12.2 0.0 1.2 1 0 0 1 1 1 0 Tryptophan synthase alpha chain FMN_dh PF01070.16 NM_020046.3_2 - 0.051 12.4 0.8 0.72 8.7 0.8 2.2 2 1 0 2 2 2 0 FMN-dependent dehydrogenase Hus1 PF04005.10 NM_153072.2_1 - 7.6e-74 248.3 0.1 9e-74 248.1 0.1 1.0 1 0 0 1 1 1 1 Hus1-like protein Xlink PF00193.15 NM_007789.3_2 - 5.9e-59 196.3 0.0 1.7e-29 101.9 0.0 2.9 2 0 0 2 2 2 2 Extracellular link domain Lectin_C PF00059.19 NM_007789.3_2 - 4e-24 85.3 6.1 1.2e-22 80.5 0.8 3.5 3 0 0 3 3 3 1 Lectin C-type domain Sushi PF00084.18 NM_007789.3_2 - 8.3e-10 39.0 0.4 8.3e-10 39.0 0.4 2.2 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) V-set PF07686.15 NM_007789.3_2 - 1.6e-09 37.7 0.0 2.8e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain hEGF PF12661.5 NM_007789.3_2 - 5.1e-05 23.7 3.8 5.1e-05 23.7 3.8 6.3 5 0 0 5 5 5 2 Human growth factor-like EGF EGF PF00008.25 NM_007789.3_2 - 5.3e-05 23.3 29.7 0.0003 20.9 13.2 5.3 5 0 0 5 5 5 2 EGF-like domain DMP1 PF07263.9 NM_016779.2_1 - 2e-201 670.3 160.3 2.3e-201 670.1 160.3 1.0 1 0 0 1 1 1 1 Dentin matrix protein 1 (DMP1) DUF2448 PF10476.7 NM_016779.2_1 - 2.2 8.0 0.0 2.2 8.0 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function C-terminus (DUF2448) Ion_trans_2 PF07885.14 NM_001281847.1_1 - 5e-37 125.6 25.4 1e-18 66.9 13.3 3.6 3 1 1 4 4 4 3 Ion channel bZIP_Maf PF03131.15 NM_001281847.1_1 - 0.063 13.7 1.5 0.12 12.8 1.5 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor zf-C2H2 PF00096.24 NM_172993.3_2 - 0.00039 20.6 2.6 0.00039 20.6 2.6 7.2 9 0 0 9 9 9 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_172993.3_2 - 0.0013 19.3 8.4 0.0041 17.7 2.6 8.9 10 0 0 10 10 10 4 C2H2-type zinc finger zf-met PF12874.5 NM_172993.3_2 - 0.031 14.5 5.8 2 8.7 0.2 4.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.5 NM_172993.3_2 - 0.13 12.5 25.6 0.65 10.2 0.7 5.4 3 2 1 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_aberr PF17017.3 NM_172993.3_2 - 0.17 11.9 17.0 4.2 7.4 0.4 4.1 3 1 1 4 4 4 0 Aberrant zinc-finger zf-FCS PF06467.12 NM_172993.3_2 - 0.88 9.5 9.1 0.44 10.4 0.2 4.0 4 0 0 4 4 4 0 MYM-type Zinc finger with FCS sequence motif zf-BED PF02892.13 NM_172993.3_2 - 2 8.4 37.7 2.4 8.1 0.1 6.9 6 2 1 7 7 7 0 BED zinc finger zf-C2HE PF16278.3 NM_172993.3_2 - 3.9 7.9 28.1 1.1 9.6 0.2 5.5 5 2 1 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger DUF629 PF04780.10 NM_172993.3_2 - 6.8 5.0 12.2 6.8 5.0 1.8 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF629) SH2 PF00017.22 NM_007707.3_2 - 3.2e-09 36.6 0.0 5.5e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 NM_007707.3_2 - 0.00023 21.3 0.0 0.00054 20.1 0.0 1.7 1 0 0 1 1 1 1 SOCS box zf-H2C2_2 PF13465.4 NM_029869.1_2 - 1.7e-42 141.8 32.9 2.4e-09 37.1 0.4 7.5 6 0 0 6 6 6 5 Zinc-finger double domain SCAN PF02023.15 NM_029869.1_2 - 8.9e-40 134.3 2.0 2.1e-39 133.1 2.0 1.7 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 NM_029869.1_2 - 6.2e-33 111.3 48.6 1.6e-06 28.1 0.4 7.9 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_029869.1_2 - 2.8e-09 36.6 30.6 0.17 11.7 1.6 6.9 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_4 PF13894.4 NM_029869.1_2 - 3.5e-06 27.2 55.4 0.038 14.7 0.4 8.6 9 0 0 9 9 6 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_029869.1_2 - 6.3e-06 26.1 24.4 0.012 15.5 1.4 4.9 3 1 2 5 5 5 4 Zinc ribbon domain zf-C2H2_11 PF16622.3 NM_029869.1_2 - 0.00044 19.8 3.4 0.00044 19.8 3.4 6.9 7 0 0 7 7 7 3 zinc-finger C2H2-type Roughex PF06020.9 NM_029869.1_2 - 0.074 12.0 4.1 0.12 11.4 4.1 1.1 1 0 0 1 1 1 0 Drosophila roughex protein C1_4 PF07975.10 NM_029869.1_2 - 0.94 9.7 19.6 0.93 9.7 1.4 4.5 2 2 2 4 4 4 0 TFIIH C1-like domain XPA_N PF01286.16 NM_029869.1_2 - 5 7.1 40.0 11 6.1 0.3 8.3 8 0 0 8 8 8 0 XPA protein N-terminal DUF3268 PF11672.6 NM_029869.1_2 - 8.4 6.6 11.6 9.5 6.5 0.2 3.2 3 0 0 3 3 3 0 zinc-finger-containing domain SecE PF00584.18 NM_029869.1_3 - 0.017 14.9 0.0 0.017 14.9 0.0 1.8 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex zf-RING_2 PF13639.4 NM_013876.3_1 - 1.9e-11 43.9 6.0 4.2e-11 42.8 6.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.3 NM_013876.3_1 - 2.3e-10 39.8 4.4 2.3e-10 39.8 4.4 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.4 NM_013876.3_1 - 4.8e-07 29.5 2.5 1.4e-06 28.1 2.5 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_013876.3_1 - 4.3e-06 26.3 6.0 1e-05 25.1 6.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_013876.3_1 - 1.1e-05 25.5 5.6 3.4e-05 23.9 5.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 NM_013876.3_1 - 3.4e-05 23.5 3.5 8.9e-05 22.1 3.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_013876.3_1 - 5.2e-05 22.9 2.2 0.00011 21.9 2.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_013876.3_1 - 0.00025 20.8 1.7 0.00065 19.5 1.7 1.8 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.3 NM_013876.3_1 - 0.00078 18.9 2.8 0.0016 17.9 2.8 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.4 NM_013876.3_1 - 0.0016 18.1 2.2 0.0033 17.1 2.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Engrail_1_C_sig PF10525.7 NM_013876.3_2 - 0.44 9.7 2.2 0.97 8.6 2.2 1.5 1 0 0 1 1 1 0 Engrailed homeobox C-terminal signature domain Hist_deacetyl PF00850.17 NM_010411.2_1 - 1.3e-78 264.5 0.1 1.8e-78 264.0 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Lectin_C PF00059.19 NM_023134.4_3 - 7.1e-20 71.6 0.0 1.3e-19 70.7 0.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 NM_023134.4_3 - 2.2e-10 40.0 35.2 3.8e-05 23.2 15.7 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Cadherin PF00028.15 NM_033577.1_1 - 2e-85 281.3 0.0 1e-20 73.8 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_033577.1_1 - 5.1e-32 109.4 0.1 4.7e-28 96.7 0.0 4.5 5 0 0 5 5 5 2 Cadherin-like Cadherin_tail PF15974.3 NM_033577.1_1 - 8.8e-26 90.7 2.8 1.6e-25 89.9 2.8 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 NM_033577.1_1 - 7e-19 68.3 0.5 1.9e-18 66.9 0.2 2.0 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 NM_033577.1_1 - 9.3e-06 25.5 1.3 4.9 7.1 0.0 5.2 5 0 0 5 5 5 2 Cadherin-like PQQ PF01011.19 NM_033577.1_1 - 0.15 11.9 0.0 32 4.5 0.0 3.3 3 0 0 3 3 3 0 PQQ enzyme repeat He_PIG PF05345.10 NM_033577.1_1 - 0.17 11.9 1.5 27 4.9 0.0 3.6 3 0 0 3 3 3 0 Putative Ig domain Cadherin PF00028.15 NM_130448.3_3 - 1.2e-83 275.5 1.1 7.7e-18 64.6 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_130448.3_3 - 1.1e-15 57.1 0.0 2e-14 53.0 0.0 3.1 4 0 0 4 4 4 1 Cadherin-like Cadherin_3 PF16184.3 NM_130448.3_3 - 8.6e-06 25.6 2.8 1.8 8.4 0.0 5.2 5 0 0 5 5 5 3 Cadherin-like Cadherin_C_2 PF16492.3 NM_130448.3_3 - 0.0012 19.4 0.4 0.0038 17.8 0.4 1.9 1 1 0 1 1 1 1 Cadherin cytoplasmic C-terminal BBS1 PF14779.4 NM_130448.3_3 - 0.089 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 TMEM154 PF15102.4 NM_130448.3_3 - 0.12 12.2 0.1 0.3 10.9 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family Pkinase PF00069.23 NM_001177973.1_3 - 1.8e-38 132.3 0.0 2.7e-38 131.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001177973.1_3 - 5.4e-35 120.8 0.0 3.2e-34 118.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Death PF00531.20 NM_001177973.1_3 - 1.5e-10 41.0 1.2 2.7e-10 40.2 1.2 1.5 1 0 0 1 1 1 1 Death domain RAMP PF04901.11 NM_001177973.1_3 - 0.011 15.6 0.1 0.021 14.7 0.1 1.4 1 0 0 1 1 1 0 Receptor activity modifying family APH PF01636.21 NM_001177973.1_3 - 0.032 14.0 1.0 0.044 13.6 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family RhoGEF PF00621.18 NM_001310594.1_3 - 2e-45 155.1 3.8 2.8e-45 154.7 3.8 1.2 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 NM_001310594.1_3 - 4.8e-10 38.8 2.4 8.3e-10 38.0 2.4 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001310594.1_3 - 1.8e-09 37.1 0.1 3.7e-09 36.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 NM_001310594.1_3 - 2.4e-07 31.1 0.2 4.2e-07 30.3 0.2 1.4 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.15 NM_001310594.1_3 - 6.3e-07 28.9 0.0 1.3e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Myosin_TH1 PF06017.11 NM_001310594.1_3 - 0.091 12.3 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding p450 PF00067.20 NM_028191.2_1 - 1.7e-158 528.1 0.0 1.9e-158 527.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-H2C2_2 PF13465.4 NM_011762.3_2 - 0.0021 18.3 29.0 0.011 16.1 2.8 5.9 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.24 NM_011762.3_2 - 0.017 15.4 4.6 0.017 15.4 0.1 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_011762.3_2 - 0.99 10.3 6.2 1.9 9.4 0.1 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_011762.3_3 - 9.5e-94 303.9 136.4 1.1e-07 31.8 0.7 19.8 19 0 0 19 19 19 18 Zinc-finger double domain zf-C2H2 PF00096.24 NM_011762.3_3 - 6.8e-63 205.7 124.0 1.6e-05 24.9 1.7 17.4 17 0 0 17 17 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_011762.3_3 - 3.5e-33 111.3 135.0 0.01 16.5 0.8 18.1 18 0 0 18 18 17 16 C2H2-type zinc finger KRAB PF01352.25 NM_011762.3_3 - 6.9e-22 76.7 0.5 1.3e-21 75.9 0.5 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_011762.3_3 - 4.1e-17 61.5 107.6 0.0018 18.0 0.3 17.1 16 0 0 16 16 16 11 C2H2-type zinc finger zf-C2H2_8 PF15909.3 NM_011762.3_3 - 1.5e-09 37.9 65.8 0.01 16.0 2.8 7.6 1 1 6 7 7 7 5 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.6 NM_011762.3_3 - 1.7e-07 31.2 76.7 0.013 15.7 0.1 15.2 16 0 0 16 16 16 5 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_011762.3_3 - 4.9e-05 23.9 58.1 0.52 11.0 2.0 8.8 4 2 5 9 9 9 6 zinc-ribbon family Zn-ribbon_8 PF09723.8 NM_011762.3_3 - 0.00082 19.3 101.7 0.083 12.9 2.9 12.1 4 3 12 16 16 15 9 Zinc ribbon domain zf-met PF12874.5 NM_011762.3_3 - 0.0011 19.1 0.3 0.0011 19.1 0.3 12.5 15 0 0 15 15 14 3 Zinc-finger of C2H2 type DUF1495 PF07381.9 NM_011762.3_3 - 0.004 16.8 0.0 0.87 9.3 0.0 2.5 2 0 0 2 2 2 1 Winged helix DNA-binding domain (DUF1495) Cys_rich_CPXG PF14255.4 NM_011762.3_3 - 0.032 14.0 0.1 0.032 14.0 0.1 4.2 4 0 0 4 4 3 0 Cysteine-rich CPXCG Zn_Tnp_IS1595 PF12760.5 NM_011762.3_3 - 0.74 9.7 81.9 1.1 9.2 1.3 11.6 7 4 5 12 12 12 0 Transposase zinc-ribbon domain zf-C2H2_11 PF16622.3 NM_011762.3_3 - 0.92 9.2 0.0 0.92 9.2 0.0 15.3 17 0 0 17 17 16 0 zinc-finger C2H2-type Exo70 PF03081.13 NM_016857.2_3 - 1.6e-77 261.0 2.1 1.6e-77 261.0 2.1 1.6 2 0 0 2 2 2 1 Exo70 exocyst complex subunit COG5 PF10392.7 NM_016857.2_3 - 0.017 15.1 3.4 0.063 13.3 3.4 2.0 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Vps52 PF04129.10 NM_016857.2_3 - 0.019 13.6 6.8 0.064 11.9 1.2 2.2 2 0 0 2 2 2 0 Vps52 / Sac2 family RolB_RolC PF02027.15 NM_016857.2_3 - 0.1 12.2 0.1 0.28 10.7 0.1 1.8 1 0 0 1 1 1 0 RolB/RolC glucosidase family Ank_5 PF13857.4 NM_009878.3_3 - 1.6e-18 66.3 0.3 3.7e-09 36.6 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_009878.3_3 - 5.4e-16 58.8 0.0 8.6e-09 35.7 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_009878.3_3 - 3.3e-15 56.1 0.0 4.5e-06 27.0 0.0 4.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_009878.3_3 - 1.8e-10 40.7 0.7 0.0097 16.2 0.0 4.6 5 1 1 6 6 6 3 Ankyrin repeat Ank_3 PF13606.4 NM_009878.3_3 - 8.8e-07 28.6 0.0 0.48 11.0 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Sugar_tr PF00083.22 NM_001012363.2_1 - 4.2e-104 348.8 17.0 5.3e-104 348.5 17.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 NM_001012363.2_1 - 1.9e-23 82.8 29.7 1.4e-14 53.7 11.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Atrophin-1 PF03154.13 NM_001291028.1_1 - 0.02 13.1 16.9 0.045 11.9 16.9 1.5 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 NM_001291028.1_1 - 4.6 7.1 19.8 25 4.7 19.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 NM_001291028.1_2 - 0.16 11.8 10.9 0.29 11.0 10.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Fez1 PF06818.13 NM_001291028.1_3 - 5.5e-60 203.1 10.1 5.5e-60 203.1 10.1 3.0 3 0 0 3 3 3 2 Fez1 DUF812 PF05667.9 NM_001291028.1_3 - 6.2e-05 22.0 12.8 6.2e-05 22.0 12.8 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF812) Atg14 PF10186.7 NM_001291028.1_3 - 0.0027 16.7 0.8 0.0027 16.7 0.8 3.1 1 1 2 3 3 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 ADH_zinc_N PF00107.24 NM_025297.2_3 - 4e-17 62.2 0.0 6.7e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 NM_025297.2_3 - 1.3e-08 34.6 0.0 2.8e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 NM_025297.2_3 - 3e-05 24.9 0.0 6.9e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pkinase_Tyr PF07714.15 NM_001277217.1_3 - 1.1e-36 126.4 0.0 1.5e-36 125.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001277217.1_3 - 2.2e-35 122.2 0.0 3.2e-35 121.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 NM_001277217.1_3 - 4.2e-15 54.8 0.9 9e-15 53.7 0.9 1.6 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 NM_001277217.1_3 - 1.1e-12 48.6 11.3 3.9e-12 46.9 11.3 2.0 1 0 0 1 1 1 1 Activin types I and II receptor domain FTA2 PF13095.4 NM_001277217.1_3 - 0.04 13.4 0.0 0.069 12.6 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 eIF-5a PF01287.18 NM_001166590.1_3 - 5.2e-25 87.2 0.2 7.5e-25 86.7 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.10 NM_001166590.1_3 - 0.025 14.5 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain SRCR PF00530.16 NM_009852.3_2 - 5.1e-57 190.5 29.5 2.6e-26 91.9 4.8 3.4 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 NM_009852.3_2 - 7.1e-10 39.2 14.6 0.0052 17.2 1.4 3.7 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain DAG1 PF05454.9 NM_009852.3_2 - 0.092 12.0 0.0 0.092 12.0 0.0 1.9 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) PROCN PF08083.9 NM_138659.2_1 - 1.1e-235 781.8 8.6 1.1e-235 781.8 8.6 1.6 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.6 NM_138659.2_1 - 1.9e-130 433.3 0.6 3.5e-130 432.4 0.6 1.5 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.7 NM_138659.2_1 - 1.6e-93 310.7 4.3 5.1e-92 305.8 3.7 2.5 1 1 1 2 2 2 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.9 NM_138659.2_1 - 2.3e-87 290.5 3.7 7.1e-87 288.9 3.7 1.9 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.7 NM_138659.2_1 - 2.5e-74 247.6 0.0 5e-74 246.6 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.9 NM_138659.2_1 - 1e-53 180.3 0.0 2.4e-53 179.1 0.0 1.7 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.7 NM_138659.2_1 - 2.1e-48 162.5 0.7 5.2e-48 161.2 0.7 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.19 NM_138659.2_1 - 5.9e-14 51.9 0.0 1.6e-13 50.5 0.0 1.8 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Pkinase PF00069.23 NM_001293639.1_3 - 1.1e-69 234.6 0.0 2.2e-69 233.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001293639.1_3 - 1.2e-44 152.5 0.0 2.4e-44 151.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001293639.1_3 - 1.8e-05 24.1 0.0 1.8e-05 24.1 0.0 2.5 3 0 0 3 3 3 1 Kinase-like APH PF01636.21 NM_001293639.1_3 - 0.00076 19.3 2.2 0.14 11.9 0.0 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family muHD PF10291.7 NM_001285859.1_2 - 4.8e-71 239.1 0.0 6.5e-71 238.7 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Adap_comp_sub PF00928.19 NM_001285859.1_2 - 8.8e-07 28.4 0.0 2.3e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Adaptor complexes medium subunit family ANAPC4_WD40 PF12894.5 NM_025793.3_2 - 0.00028 21.0 0.0 0.11 12.7 0.0 3.3 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 NM_025793.3_2 - 0.065 14.0 1.9 2 9.3 0.2 3.6 2 1 1 3 3 3 0 WD domain, G-beta repeat GON PF08685.9 NM_175314.3_2 - 5.2e-82 274.4 0.4 5.2e-82 274.4 0.4 2.5 2 0 0 2 2 2 1 GON domain TSP_1 PF00090.17 NM_175314.3_2 - 7.5e-62 205.2 213.3 1e-06 28.7 6.7 16.6 15 2 2 17 17 17 13 Thrombospondin type 1 domain ADAM_spacer1 PF05986.12 NM_175314.3_2 - 1.9e-32 111.5 0.0 2.9e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 DUF4602 PF15375.4 NM_025615.2_1 - 2.2e-32 112.1 20.5 2.2e-32 112.1 20.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4602) Whib PF02467.14 NM_025615.2_3 - 5.7 7.5 8.4 1.2 9.7 2.8 2.3 2 0 0 2 2 2 0 Transcription factor WhiB GSK-3_bind PF05350.10 NM_013788.2_2 - 9.2e-116 385.1 12.9 1.2e-115 384.7 12.9 1.2 1 0 0 1 1 1 1 Glycogen synthase kinase-3 binding ubiquitin PF00240.21 NM_026261.2_3 - 4.7e-15 54.9 0.0 7.3e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 NM_026261.2_3 - 0.00023 20.8 0.0 0.00036 20.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF4351 PF14261.4 NM_026261.2_3 - 0.033 14.1 3.6 0.073 13.0 3.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4351) TTC5_OB PF16669.3 NM_001080949.2_3 - 1.3e-40 137.5 0.0 2.1e-40 136.9 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat protein 5 OB fold domain TPR_11 PF13414.4 NM_001080949.2_3 - 1.4e-07 31.0 5.4 8.5e-05 22.0 0.0 4.3 4 1 1 5 5 5 1 TPR repeat TPR_2 PF07719.15 NM_001080949.2_3 - 3.1e-07 29.9 9.9 0.0017 18.2 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001080949.2_3 - 9.9e-07 29.2 4.9 0.062 13.9 0.0 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001080949.2_3 - 4.9e-06 26.0 9.4 0.099 12.4 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001080949.2_3 - 0.00019 21.5 0.4 0.083 13.2 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001080949.2_3 - 0.0037 17.6 3.4 0.083 13.3 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001080949.2_3 - 0.0065 16.5 9.0 0.045 13.8 0.0 4.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001080949.2_3 - 0.0095 16.6 0.2 0.64 10.9 0.0 3.5 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001080949.2_3 - 0.057 13.6 3.9 0.45 10.7 0.0 3.3 3 2 0 3 3 3 0 Tetratricopeptide repeat Abi_C PF14355.4 NM_001080949.2_3 - 0.12 12.3 0.0 20 5.3 0.0 2.9 2 0 0 2 2 2 0 Abortive infection C-terminus Interfer-bind PF09294.8 NM_008349.5_3 - 2.6e-30 104.7 0.3 3.3e-29 101.1 0.0 2.2 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.15 NM_008349.5_3 - 4e-15 55.4 1.5 9.1e-15 54.3 0.0 2.2 2 0 0 2 2 2 1 Tissue factor fn3 PF00041.19 NM_008349.5_3 - 2.4e-06 27.7 3.4 0.0039 17.4 1.0 2.7 2 1 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_008349.5_3 - 0.039 14.4 2.0 1.7 9.1 0.1 2.4 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain HemY_N PF07219.11 NM_008349.5_3 - 5.7 7.0 5.7 0.33 11.0 0.3 1.7 2 0 0 2 2 2 0 HemY protein N-terminus Pkinase PF00069.23 NM_175093.2_1 - 3.3e-25 88.8 0.0 4.5e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_175093.2_1 - 7.3e-09 35.1 0.0 1.1e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_175093.2_1 - 0.069 12.3 0.0 0.094 11.9 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Fascin PF06268.11 NM_007984.2_2 - 3.4e-123 403.8 1.0 3.1e-34 117.4 0.0 4.1 4 0 0 4 4 4 4 Fascin domain FRG1 PF06229.10 NM_007984.2_2 - 1e-17 64.4 0.1 0.0089 15.6 0.0 6.3 3 3 4 7 7 7 6 FRG1-like domain DUF569 PF04601.11 NM_007984.2_2 - 0.01 15.4 0.0 0.44 10.1 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF569) Macro PF01661.19 NM_001289490.1_1 - 8.8e-06 25.6 0.0 1.5e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Macro domain PSII_Pbs27 PF13326.4 NM_001289490.1_1 - 0.16 12.1 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Photosystem II Pbs27 IBR PF01485.19 NM_001146349.1_2 - 2.7e-13 49.8 24.9 5e-08 32.9 8.5 3.6 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain IncA PF04156.12 NM_001146349.1_2 - 0.063 12.9 2.4 0.11 12.2 2.4 1.3 1 0 0 1 1 1 0 IncA protein Anoctamin PF04547.10 NM_207031.2_1 - 6.4e-161 535.8 7.0 9.3e-161 535.3 7.0 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 NM_207031.2_1 - 8.5e-62 208.7 0.0 1.2e-61 208.2 0.0 1.2 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Ank_2 PF12796.5 NM_011266.2_1 - 5.9e-20 71.5 0.0 6.5e-11 42.5 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_011266.2_1 - 1.1e-16 60.5 0.5 7.1e-09 35.7 0.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_011266.2_1 - 6.6e-14 52.0 0.1 5.8e-08 33.0 0.0 2.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_011266.2_1 - 3.4e-13 48.3 0.0 0.013 15.9 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.28 NM_011266.2_1 - 1.5e-12 47.2 0.0 0.0049 17.1 0.1 4.2 4 0 0 4 4 4 3 Ankyrin repeat Hormone_recep PF00104.28 NM_009473.3_1 - 9.5e-28 97.1 0.3 1.5e-27 96.4 0.3 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_009473.3_1 - 6.4e-25 87.3 14.4 1.1e-24 86.5 14.4 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) PSS PF03034.13 NM_008959.3_1 - 3.1e-105 351.7 23.0 3.1e-105 351.7 23.0 1.7 2 0 0 2 2 2 1 Phosphatidyl serine synthase Cyt_b-c1_8 PF10890.6 NM_008959.3_1 - 0.12 12.7 0.1 0.25 11.6 0.1 1.5 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 zf-H2C2_2 PF13465.4 NM_001081007.1_3 - 1.1e-55 183.5 54.2 2.2e-08 34.0 1.7 11.4 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001081007.1_3 - 7.9e-46 151.9 69.1 4.4e-06 26.7 0.7 10.3 11 0 0 11 11 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001081007.1_3 - 3.3e-30 102.0 63.4 0.0014 19.2 0.3 10.2 10 0 0 10 10 10 9 C2H2-type zinc finger KRAB PF01352.25 NM_001081007.1_3 - 1.9e-24 84.9 0.1 3.7e-24 84.0 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001081007.1_3 - 8e-10 38.3 53.7 0.095 12.6 2.8 9.8 9 0 0 9 9 9 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001081007.1_3 - 4.2e-07 29.8 43.0 0.0055 16.7 1.0 6.9 5 1 3 8 8 8 4 Zinc ribbon domain DUF3268 PF11672.6 NM_001081007.1_3 - 0.00014 22.1 31.5 0.25 11.6 1.6 5.3 3 2 1 5 5 5 3 zinc-finger-containing domain zf-Di19 PF05605.10 NM_001081007.1_3 - 0.019 15.1 2.6 0.019 15.1 2.6 5.6 2 1 4 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.4 NM_001081007.1_3 - 0.023 14.4 0.6 0.023 14.4 0.6 7.0 9 0 0 9 9 8 0 zinc-finger of a C2HC-type FYDLN_acid PF09538.8 NM_001081007.1_3 - 0.061 13.9 21.7 4.1 8.0 0.0 7.5 1 1 6 7 7 7 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_15 PF17032.3 NM_001081007.1_3 - 0.1 13.2 36.2 0.86 10.3 2.2 5.2 1 1 7 8 8 8 0 zinc-ribbon family zf-LYAR PF08790.9 NM_001081007.1_3 - 1.1 9.1 44.0 0.094 12.5 0.4 9.1 9 0 0 9 9 9 0 LYAR-type C2HC zinc finger C1_4 PF07975.10 NM_001081007.1_3 - 2.7 8.2 38.9 0.24 11.6 3.4 6.4 3 2 4 8 8 8 0 TFIIH C1-like domain zf-C4_ClpX PF06689.11 NM_001081007.1_3 - 5.7 6.8 14.4 0.44 10.4 0.1 4.3 4 0 0 4 4 3 0 ClpX C4-type zinc finger zf-UBP PF02148.17 NM_001081007.1_3 - 5.9 7.2 38.9 9.4 6.5 6.0 6.6 1 1 2 3 3 3 0 Zn-finger in ubiquitin-hydrolases and other protein Transthyretin PF00576.19 NM_029821.2_3 - 5.3e-38 130.0 0.0 7e-38 129.6 0.0 1.2 1 0 0 1 1 1 1 HIUase/Transthyretin family EF-hand_2 PF09068.9 NM_001314035.1_2 - 8.5e-41 138.8 1.3 1.7e-40 137.9 1.3 1.5 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.9 NM_001314035.1_2 - 1.7e-39 134.0 0.0 4.4e-39 132.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand ZZ PF00569.15 NM_001314035.1_2 - 2.2e-19 68.8 4.2 4.7e-19 67.8 4.2 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type Miff PF05644.9 NM_001314035.1_2 - 0.0017 18.0 3.9 0.0031 17.1 3.9 1.4 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff DUF972 PF06156.11 NM_001314035.1_2 - 0.0093 16.4 4.7 2.8 8.5 1.5 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF972) bZIP_1 PF00170.19 NM_001314035.1_2 - 0.12 12.4 8.2 1.7 8.7 0.8 2.6 2 0 0 2 2 2 0 bZIP transcription factor LRRFIP PF09738.7 NM_001314035.1_2 - 0.14 11.5 7.9 0.64 9.3 1.4 2.2 2 0 0 2 2 2 0 LRRFIP family SOGA PF11365.6 NM_001314035.1_2 - 0.25 12.4 9.7 1.3 10.1 1.8 2.5 1 1 1 2 2 2 0 Protein SOGA CEP63 PF17045.3 NM_001314035.1_2 - 0.53 10.0 8.6 4.8 6.9 0.9 2.4 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa Nnf1 PF03980.12 NM_001314035.1_2 - 0.68 10.2 10.8 4 7.7 2.5 2.5 1 1 1 2 2 2 0 Nnf1 IncA PF04156.12 NM_001314035.1_2 - 1.5 8.4 12.0 5.7 6.5 1.8 2.5 2 0 0 2 2 2 0 IncA protein Rootletin PF15035.4 NM_001314035.1_2 - 3.9 7.4 11.0 7.6 6.4 1.6 2.3 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Lectin_C PF00059.19 NM_010653.4_1 - 6e-12 46.1 4.2 1.1e-11 45.3 4.2 1.5 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 NM_010653.4_1 - 1.3 8.5 4.9 2.5 7.6 4.9 1.8 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like CREPT PF16566.3 NM_027434.3_3 - 6.2e-62 208.0 6.2 1.4e-61 206.8 6.2 1.7 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour CTD_bind PF04818.11 NM_027434.3_3 - 1.2e-21 77.2 0.1 6.5e-21 74.8 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CTK3 PF12243.6 NM_027434.3_3 - 0.038 13.9 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 Edc3_linker PF16598.3 NM_153799.3_2 - 7.8e-44 148.2 8.9 1.4e-43 147.4 8.9 1.4 1 0 0 1 1 1 1 Linker region of enhancer of mRNA-decapping protein 3 YjeF_N PF03853.13 NM_153799.3_2 - 9.1e-19 67.8 0.0 1.4e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.8 NM_153799.3_2 - 6.5e-17 62.2 0.0 1.7e-16 60.8 0.0 1.7 2 0 0 2 2 2 1 FDF domain LSM14 PF12701.5 NM_153799.3_2 - 2.6e-09 36.9 0.0 5.2e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain DUF5096 PF17019.3 NM_153799.3_2 - 0.15 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5096) NTF2 PF02136.18 NM_001080797.2_1 - 5e-32 110.8 0.1 7.6e-32 110.2 0.1 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.20 NM_001080797.2_1 - 2.9e-13 49.3 0.1 5.7e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001080797.2_1 - 3.1e-05 23.9 0.0 6.2e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif DUF986 PF06173.10 NM_026325.3_2 - 0.03 14.2 0.2 0.059 13.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF986) DUF3333 PF11812.6 NM_026325.3_2 - 0.38 10.8 3.2 0.32 11.1 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3333) A_deaminase PF00962.20 NM_001290811.1_2 - 1.4e-26 93.5 0.0 1.8e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Arm PF00514.21 NM_026163.2_2 - 1.1e-31 107.8 0.5 4.1e-07 29.7 0.1 6.3 6 0 0 6 6 6 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 NM_026163.2_2 - 0.0059 16.8 0.3 0.076 13.3 0.1 2.5 2 0 0 2 2 2 1 HEAT repeats Atx10homo_assoc PF09759.7 NM_026163.2_2 - 0.017 15.0 1.0 0.093 12.7 0.4 2.5 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_N PF03224.12 NM_026163.2_2 - 0.021 14.0 0.4 1.1 8.4 0.0 2.2 2 0 0 2 2 2 0 V-ATPase subunit H SelP_C PF04593.12 NM_026163.2_2 - 0.077 12.9 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 Selenoprotein P, C terminal region HEAT_EZ PF13513.4 NM_026163.2_2 - 0.097 13.0 0.1 1.3 9.4 0.1 2.8 3 0 0 3 3 3 0 HEAT-like repeat HEAT PF02985.20 NM_026163.2_2 - 0.13 12.4 0.3 33 4.9 0.1 3.2 3 0 0 3 3 3 0 HEAT repeat DUF383 PF04063.12 NM_026163.2_2 - 0.21 11.1 2.3 1.2 8.7 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF383) Claudin_2 PF13903.4 NM_001004182.3_2 - 1.2e-10 41.4 0.4 1.2e-10 41.4 0.4 2.9 3 1 0 3 3 3 1 PMP-22/EMP/MP20/Claudin tight junction 7tm_1 PF00001.19 NM_001310734.1_1 - 2.7e-29 102.1 23.1 3.1e-21 75.7 13.9 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001310734.1_1 - 1.6e-08 34.1 17.3 9.2e-05 21.8 7.6 2.2 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx APG9 PF04109.14 NM_001002897.3_3 - 5.6e-98 328.3 0.0 7.1e-98 328.0 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Calreticulin PF00262.16 NM_007591.3_2 - 1.4e-80 270.8 15.2 9.8e-62 208.8 4.9 2.9 2 1 1 3 3 3 2 Calreticulin family Astro_capsid_p PF12226.6 NM_007591.3_2 - 2.4 7.1 17.0 4.2 6.3 17.0 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Presenilin PF01080.15 NM_007591.3_2 - 5.7 5.4 8.9 8.2 4.9 8.9 1.1 1 0 0 1 1 1 0 Presenilin Nucleo_P87 PF07267.9 NM_007591.3_2 - 7.6 5.1 14.1 12 4.5 14.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SAPS PF04499.13 NM_007591.3_2 - 7.6 5.1 9.8 10 4.6 9.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein 7tm_4 PF13853.4 NM_001011871.1_1 - 3e-53 181.2 22.4 3.6e-53 181.0 22.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011871.1_1 - 5.9e-20 71.5 26.1 1.1e-19 70.6 26.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Shisa PF13908.4 NM_001011871.1_1 - 0.19 11.8 3.1 0.4 10.8 3.1 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator I-set PF07679.14 NM_001205343.1_3 - 6.3e-38 128.6 0.0 1.5e-14 53.7 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001205343.1_3 - 3.8e-37 126.6 0.0 7.6e-15 55.2 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Papilin_u7 PF16626.3 NM_001205343.1_3 - 1.2e-36 125.0 17.4 1.2e-36 125.0 17.4 2.8 2 0 0 2 2 1 1 Linking region between Kunitz_BPTI and I-set on papilin ADAM_spacer1 PF05986.12 NM_001205343.1_3 - 8.8e-36 122.3 0.0 1.2e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.17 NM_001205343.1_3 - 1.2e-34 118.2 69.5 1.7e-10 40.8 11.1 6.3 5 0 0 5 5 5 5 Thrombospondin type 1 domain Ig_2 PF13895.4 NM_001205343.1_3 - 1.1e-27 96.0 0.0 6e-10 39.2 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_001205343.1_3 - 6.6e-27 93.4 0.0 2.9e-09 36.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_001205343.1_3 - 4.4e-24 84.6 0.0 9.2e-05 22.4 0.0 6.0 3 3 1 4 4 4 3 Immunoglobulin V-set domain Kunitz_BPTI PF00014.21 NM_001205343.1_3 - 4.9e-18 65.0 8.1 2.6e-17 62.7 8.1 2.4 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain PLAC PF08686.9 NM_001205343.1_3 - 2.8e-11 43.8 6.1 1.1e-10 41.9 6.1 2.2 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Ig_5 PF16681.3 NM_001205343.1_3 - 4e-09 36.6 0.0 0.0036 17.6 0.0 3.7 3 0 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 NM_001205343.1_3 - 5.7e-05 23.0 0.0 0.017 15.0 0.0 2.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_001205343.1_3 - 0.0004 20.7 0.0 1 9.7 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Serum_albumin PF00273.18 NM_001252661.1_1 - 2.5e-131 434.3 43.0 4.9e-49 166.3 9.7 3.1 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 NM_001252661.1_1 - 0.00044 20.0 18.9 0.019 14.8 0.3 5.9 6 0 0 6 6 6 3 Vitamin D binding protein, domain III RhoGAP PF00620.25 NM_001113246.2_3 - 8.4e-50 168.4 0.0 1.3e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 NM_001113246.2_3 - 7.5e-16 57.6 7.5 2.5e-15 55.9 7.5 2.0 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH2 PF00017.22 NM_001113246.2_3 - 5e-13 48.8 0.1 1.1e-12 47.7 0.1 1.5 1 0 0 1 1 1 1 SH2 domain FYVE_2 PF02318.14 NM_001113246.2_3 - 0.12 12.4 2.0 0.28 11.3 2.0 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger DUF1343 PF07075.9 NM_146071.2_2 - 0.052 12.8 0.3 0.18 11.0 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1343) V-set PF07686.15 NM_001102474.1_3 - 1.3e-14 54.2 0.0 2.5e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001102474.1_3 - 5.2e-09 36.5 0.0 6.2e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_001102474.1_3 - 2.6e-06 27.2 0.0 0.01 15.8 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.10 NM_001102474.1_3 - 8.5e-06 25.6 0.0 2.2e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 NM_001102474.1_3 - 0.00066 19.8 0.1 0.83 9.9 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001102474.1_3 - 0.00091 19.2 0.0 0.038 14.0 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain PMP22_Claudin PF00822.18 NM_001102474.1_3 - 3.5 7.3 10.1 0.1 12.4 0.5 2.8 2 1 1 3 3 3 0 PMP-22/EMP/MP20/Claudin family DUF4231 PF14015.4 NM_001102474.1_3 - 5 7.5 5.3 39 4.7 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) MITF_TFEB_C_3_N PF15951.3 NM_172472.3_3 - 1.7e-54 184.4 3.5 1.7e-54 184.4 3.5 1.8 2 0 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 NM_172472.3_3 - 2.6e-17 63.9 3.4 2.6e-17 63.9 3.4 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.24 NM_172472.3_3 - 9.1e-16 57.4 0.7 9.1e-16 57.4 0.7 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Josephin PF02099.15 NM_029705.3_3 - 2.1e-53 180.6 0.0 3.2e-53 180.0 0.0 1.3 1 0 0 1 1 1 1 Josephin SUIM_assoc PF16619.3 NM_029705.3_3 - 1.7e-23 82.4 6.5 3e-23 81.5 6.5 1.4 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 UIM PF02809.18 NM_029705.3_3 - 1.6e-06 27.5 30.1 0.00031 20.3 0.8 4.4 5 0 0 5 5 5 3 Ubiquitin interaction motif Pkinase_Tyr PF07714.15 NM_007939.2_1 - 7.1e-91 303.9 0.0 9.3e-91 303.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 NM_007939.2_1 - 5.7e-64 215.3 0.0 8.1e-64 214.8 0.0 1.2 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 NM_007939.2_1 - 3.1e-42 144.6 0.0 4.5e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 NM_007939.2_1 - 4.5e-30 103.7 0.1 8.9e-18 64.3 0.1 3.0 2 1 0 2 2 2 2 Fibronectin type III domain SAM_1 PF00536.28 NM_007939.2_1 - 1.7e-19 69.9 0.0 2.9e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_007939.2_1 - 3.6e-14 52.5 0.0 7.1e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.4 NM_007939.2_1 - 6.1e-08 33.2 0.0 1.2e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Pur_ac_phosph_N PF16656.3 NM_007939.2_1 - 7.8e-07 29.5 0.1 1.8e-06 28.3 0.1 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 NM_007939.2_1 - 5.1e-06 26.4 0.4 0.0018 18.2 0.0 2.4 2 0 0 2 2 2 1 Fibronectin type III domain Ephrin_rec_like PF07699.11 NM_007939.2_1 - 0.00078 19.0 3.6 0.00078 19.0 3.6 3.2 3 0 0 3 3 3 1 Putative ephrin-receptor like Kdo PF06293.12 NM_007939.2_1 - 0.0031 16.8 0.0 0.0051 16.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SusE PF14292.4 NM_007939.2_1 - 0.0065 16.7 0.1 0.25 11.6 0.1 2.2 2 0 0 2 2 2 1 SusE outer membrane protein VSP PF03302.11 NM_007939.2_1 - 0.085 11.6 8.2 0.011 14.5 3.8 1.6 1 1 0 1 1 1 0 Giardia variant-specific surface protein C2 PF00168.28 NM_009306.3_3 - 3.9e-54 181.1 0.6 8e-27 93.4 0.0 2.4 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.4 NM_009306.3_3 - 0.019 14.4 0.0 2.4 7.6 0.0 2.3 2 0 0 2 2 2 0 CEP76 C2 domain MAP17 PF15807.3 NM_009306.3_3 - 0.037 14.1 0.2 0.078 13.1 0.2 1.5 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Comm PF15957.3 NM_009306.3_3 - 0.044 14.0 0.0 0.044 14.0 0.0 2.5 3 0 0 3 3 3 0 Commissureless EphA2_TM PF14575.4 NM_009306.3_3 - 0.14 12.9 0.0 0.34 11.6 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TAS2R PF05296.11 NM_207018.1_1 - 7e-76 255.1 47.2 8e-76 254.9 47.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Co_AT_N PF12557.6 NM_207018.1_3 - 0.17 11.7 2.7 0.26 11.1 2.7 1.2 1 0 0 1 1 1 0 Cob(I)alamin adenosyltransferase N terminal UPF0029 PF01205.17 NM_207018.1_3 - 0.34 11.1 1.9 0.5 10.6 1.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein family UPF0029 Neur_chan_memb PF02932.14 NM_009602.4_2 - 7.8e-84 281.3 0.0 1.1e-83 280.8 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 NM_009602.4_2 - 2.2e-72 242.9 1.7 3.1e-72 242.4 1.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.7 NM_009602.4_2 - 1.4 8.2 9.8 0.14 11.4 5.2 1.6 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Ets PF00178.20 NM_001322268.1_3 - 1.7e-33 114.8 2.7 3.1e-33 113.9 2.7 1.5 1 0 0 1 1 1 1 Ets-domain DEAD PF00270.27 NM_001024922.2_1 - 2.7e-47 160.7 0.0 7.3e-47 159.3 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001024922.2_1 - 6.5e-28 97.2 0.1 2.3e-27 95.4 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_001024922.2_1 - 3.2e-06 27.1 0.0 6.8e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.4 NM_001024922.2_1 - 0.028 14.6 2.8 0.24 11.5 0.1 3.1 3 1 0 3 3 3 0 AAA domain CAP_N PF01213.17 NM_001024922.2_2 - 9.6 5.4 6.6 14 4.9 6.6 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal NACHT PF05729.10 NM_153595.3_3 - 2.1e-08 34.1 0.0 4.1e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.4 NM_153595.3_3 - 0.00014 22.1 0.0 0.0004 20.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 NM_153595.3_3 - 0.00035 20.7 0.0 0.0008 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF4062 PF13271.4 NM_153595.3_3 - 0.00099 19.3 0.0 0.0046 17.2 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4062) Rad17 PF03215.13 NM_153595.3_3 - 0.0016 17.3 1.9 0.087 11.6 0.1 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein ATPase_2 PF01637.16 NM_153595.3_3 - 0.006 16.4 0.1 0.1 12.3 0.0 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_14 PF13173.4 NM_153595.3_3 - 0.045 13.7 0.0 0.15 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 NM_153595.3_3 - 0.053 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.11 NM_153595.3_3 - 0.064 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA PF00004.27 NM_153595.3_3 - 0.082 13.2 0.0 0.31 11.3 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Guanylate_cyc PF00211.18 NM_001037724.4_1 - 1.5e-119 396.2 0.0 5.2e-62 208.6 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.12 NM_001037724.4_1 - 1.1e-32 112.6 0.0 1.7e-32 111.9 0.0 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) AC_N PF16214.3 NM_001037724.4_1 - 1.2e-16 60.7 11.0 1.2e-16 60.7 11.0 2.0 3 0 0 3 3 3 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1170 PF06663.11 NM_177751.3_1 - 2.5e-63 213.5 9.3 1.1e-62 211.3 9.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1170) CRIC_ras_sig PF10534.7 NM_177751.3_1 - 1.1e-38 131.1 0.5 3e-38 129.7 0.1 2.0 2 0 0 2 2 2 1 Connector enhancer of kinase suppressor of ras SAM_1 PF00536.28 NM_177751.3_1 - 9.6e-20 70.7 0.4 9.6e-20 70.7 0.4 2.1 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) PH PF00169.27 NM_177751.3_1 - 2.9e-14 53.3 6.2 5e-14 52.6 4.2 2.4 2 0 0 2 2 2 1 PH domain SAM_2 PF07647.15 NM_177751.3_1 - 9.3e-14 51.2 0.4 4.1e-13 49.1 0.2 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PDZ PF00595.22 NM_177751.3_1 - 1.3e-08 34.9 0.0 3.2e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_177751.3_1 - 0.03 14.5 0.0 0.065 13.4 0.0 1.5 1 0 0 1 1 1 0 PDZ domain SAM_PNT PF02198.14 NM_177751.3_1 - 0.031 14.1 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain ATG11 PF10377.7 NM_177751.3_1 - 0.033 14.1 1.0 0.073 13.0 1.0 1.5 1 0 0 1 1 1 0 Autophagy-related protein 11 PH_9 PF15410.4 NM_177751.3_1 - 0.046 14.0 4.7 0.91 9.8 2.2 3.5 3 1 0 3 3 2 0 Pleckstrin homology domain PH_11 PF15413.4 NM_177751.3_1 - 0.58 10.5 14.6 0.25 11.6 9.9 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain KH_1 PF00013.27 NM_023670.3_1 - 2e-55 184.4 9.0 1.2e-14 53.8 0.1 4.4 4 0 0 4 4 4 4 KH domain RRM_1 PF00076.20 NM_023670.3_1 - 1.3e-14 53.6 0.0 1.3e-08 34.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_2 PF07650.15 NM_023670.3_1 - 5e-14 51.7 7.2 0.011 15.4 0.2 4.5 4 0 0 4 4 4 4 KH domain KH_4 PF13083.4 NM_023670.3_1 - 5.2e-14 51.7 0.1 0.0091 15.7 0.0 5.1 5 0 0 5 5 5 4 KH domain KH_5 PF13184.4 NM_023670.3_1 - 1.6e-05 24.7 4.7 1.2 9.1 0.1 3.9 4 0 0 4 4 4 3 NusA-like KH domain MOEP19 PF16005.3 NM_023670.3_1 - 0.00032 20.5 0.1 0.29 11.1 0.0 3.7 4 0 0 4 4 4 1 KH-like RNA-binding domain Pkinase PF00069.23 NM_080442.2_3 - 1.3e-65 221.3 0.0 1.5e-65 221.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_080442.2_3 - 1.5e-33 116.1 0.0 1.8e-33 115.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_080442.2_3 - 3.5e-06 26.4 0.0 5.2e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_080442.2_3 - 0.049 12.9 0.0 0.072 12.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Rdx PF10262.7 NM_080442.2_3 - 0.1 12.7 0.1 0.28 11.3 0.1 1.8 1 1 0 1 1 1 0 Rdx family Pkinase PF00069.23 NM_001080773.2_3 - 1.3e-67 227.9 0.0 1.6e-67 227.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001080773.2_3 - 5.2e-34 117.6 0.0 7e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH_3 PF14593.4 NM_001080773.2_3 - 1.2e-29 102.4 0.0 2.4e-29 101.4 0.0 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.4 NM_001080773.2_3 - 6.4e-07 28.8 0.0 2.5e-06 26.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.4 NM_001080773.2_3 - 0.0019 17.7 0.0 1.5 8.3 0.0 2.3 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 NM_001080773.2_3 - 0.0056 15.9 0.0 0.01 15.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001080773.2_3 - 0.0094 15.8 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family YukC PF10140.7 NM_001080773.2_3 - 0.11 11.2 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC ETRAMP PF09716.8 NM_170690.2_1 - 0.025 14.5 0.0 1.5 8.8 0.0 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Ank_2 PF12796.5 NM_170690.2_2 - 1.3e-144 471.1 48.6 1.3e-16 60.8 1.2 11.7 2 2 9 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.28 NM_170690.2_2 - 2.1e-133 429.4 64.7 1.8e-07 31.2 0.1 23.3 22 1 1 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 NM_170690.2_2 - 2.8e-120 391.1 56.1 9.8e-11 41.8 0.4 16.4 4 3 12 18 18 18 18 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_170690.2_2 - 3.9e-113 367.4 44.7 9.7e-12 44.8 0.0 16.4 4 4 13 18 18 18 18 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_170690.2_2 - 8.1e-107 336.0 35.9 0.00019 21.5 0.0 24.1 24 0 0 24 24 24 21 Ankyrin repeat ZU5 PF00791.18 NM_170690.2_2 - 4.9e-33 113.2 0.9 5.9e-27 93.7 0.0 2.6 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 NM_170690.2_2 - 3.5e-21 75.0 0.0 7.9e-21 73.9 0.0 1.6 1 0 0 1 1 1 1 Death domain Porin_3 PF01459.20 NM_011694.5_1 - 2.1e-82 276.5 4.2 2.7e-82 276.1 4.2 1.1 1 0 0 1 1 1 1 Eukaryotic porin GRP PF07172.9 NM_010200.3_1 - 3 8.4 5.7 0.3 11.7 0.9 1.7 2 0 0 2 2 2 0 Glycine rich protein family FGF PF00167.16 NM_010200.3_2 - 2.2e-42 144.0 0.3 3.4e-42 143.3 0.3 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 NM_010200.3_2 - 0.017 15.2 0.1 0.052 13.6 0.0 1.7 2 0 0 2 2 2 0 Fascin domain DUF4775 PF16001.3 NM_010200.3_2 - 0.57 9.4 4.8 0.91 8.7 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) RhoGEF PF00621.18 NM_178076.3_3 - 2.2e-39 135.4 3.3 2.2e-39 135.4 3.3 3.2 3 0 0 3 3 3 1 RhoGEF domain CRAL_TRIO_2 PF13716.4 NM_178076.3_3 - 5.7e-09 36.1 0.0 1.3e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PH PF00169.27 NM_178076.3_3 - 1.1e-08 35.4 0.1 3.9e-08 33.6 0.2 2.0 2 0 0 2 2 2 1 PH domain Spectrin PF00435.19 NM_178076.3_3 - 1.7e-08 34.8 0.2 1.7e-08 34.8 0.2 4.9 5 1 0 5 5 5 1 Spectrin repeat SH3_1 PF00018.26 NM_178076.3_3 - 9.4e-05 21.8 0.6 0.0002 20.7 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 NM_178076.3_3 - 0.001 18.7 0.5 0.0036 17.0 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain PH_10 PF15411.4 NM_178076.3_3 - 0.0084 16.2 2.4 0.016 15.3 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain MCPsignal PF00015.19 NM_178076.3_3 - 0.061 13.0 1.6 0.2 11.3 0.0 2.5 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain HR1 PF02185.14 NM_178076.3_3 - 2.4 8.2 5.6 0.98 9.4 1.1 2.7 2 0 0 2 2 2 0 Hr1 repeat Runt PF00853.17 NM_001111022.2_2 - 4.1e-72 239.7 0.1 6.5e-72 239.1 0.1 1.3 1 0 0 1 1 1 1 Runt domain RunxI PF08504.9 NM_001111022.2_2 - 4.3e-39 133.1 2.2 9.8e-39 131.9 2.2 1.6 1 0 0 1 1 1 1 Runx inhibition domain MACPF PF01823.17 NM_001145807.1_3 - 4.5e-08 33.3 0.6 1.1e-07 32.0 0.0 1.9 2 0 0 2 2 2 1 MAC/Perforin domain ASC PF00858.22 NM_011325.2_1 - 4.9e-102 341.8 10.1 6.6e-102 341.4 10.1 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Pyr_redox_2 PF07992.12 NM_001162503.1_3 - 7.3e-16 58.1 0.0 1.8e-08 33.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.10 NM_001162503.1_3 - 0.025 13.5 0.1 0.1 11.5 0.1 1.9 1 1 1 2 2 2 0 Lycopene cyclase protein Pyr_redox_3 PF13738.4 NM_001162503.1_3 - 0.1 11.7 0.3 1.6 7.8 0.1 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Spermine_synth PF01564.15 NM_001162503.1_3 - 0.12 11.2 0.1 0.2 10.5 0.1 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase FAD_binding_2 PF00890.22 NM_001162503.1_3 - 0.16 10.9 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Kinetochor_Ybp2 PF08568.8 NM_133248.2_1 - 2.4e-97 326.8 12.4 2.8e-97 326.6 12.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin Ras PF00071.20 NM_181548.2_1 - 6.6e-34 116.7 0.0 8.5e-34 116.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_181548.2_1 - 5.1e-11 42.7 0.0 8.1e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_181548.2_1 - 7.8e-07 28.6 0.0 1.1e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 NM_181548.2_1 - 1.3e-06 28.3 0.0 0.044 13.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 NM_181548.2_1 - 0.00019 21.3 0.0 0.00039 20.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_25 PF13481.4 NM_181548.2_1 - 0.00042 19.8 0.0 0.00064 19.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.16 NM_181548.2_1 - 0.0013 18.2 0.0 0.011 15.1 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B DAP3 PF10236.7 NM_181548.2_1 - 0.051 12.6 0.2 0.1 11.6 0.0 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 TPP_enzyme_M PF00205.20 NM_181548.2_1 - 0.13 11.9 0.1 0.22 11.2 0.1 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain DUF459 PF04311.11 NM_181548.2_1 - 0.13 11.1 0.0 0.23 10.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF459) AAA_16 PF13191.4 NM_181548.2_1 - 0.16 12.2 0.5 0.35 11.1 0.5 1.7 1 1 0 1 1 1 0 AAA ATPase domain CAP_GLY PF01302.23 NM_001039162.2_1 - 4.1e-47 157.9 5.1 9.1e-25 86.3 0.4 2.4 2 0 0 2 2 2 2 CAP-Gly domain Kinetocho_Slk19 PF12709.5 NM_001039162.2_1 - 0.0036 17.6 4.7 0.0036 17.6 4.7 8.4 5 4 3 10 10 10 1 Central kinetochore-associated Reo_sigmaC PF04582.10 NM_001039162.2_1 - 3.8 6.7 25.5 0.21 10.8 5.4 4.0 2 2 2 4 4 4 0 Reovirus sigma C capsid protein FlaC_arch PF05377.9 NM_001039162.2_1 - 6 7.2 21.5 12 6.2 0.1 6.0 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) SCP2 PF02036.15 NM_026942.3_2 - 4.9e-18 65.4 0.2 5.5e-17 62.0 0.0 2.3 2 1 0 2 2 2 1 SCP-2 sterol transfer family Band_7 PF01145.23 NM_026942.3_2 - 8.8e-15 55.0 0.0 1.8e-14 54.1 0.0 1.4 2 0 0 2 2 2 1 SPFH domain / Band 7 family DHQS PF01959.14 NM_026942.3_2 - 0.074 11.8 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 3-dehydroquinate synthase (EC 4.6.1.3) JAB PF01398.19 NM_001166459.1_2 - 2.3e-44 150.0 1.7 2.3e-44 150.0 1.7 2.6 2 1 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 NM_001166459.1_2 - 1.3e-06 28.1 0.1 2.2e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain HNH_5 PF14279.4 NM_001166459.1_3 - 0.15 11.8 1.8 8 6.3 2.2 2.5 2 0 0 2 2 2 0 HNH endonuclease Y_phosphatase PF00102.25 NM_001146199.1_1 - 4.1e-72 242.4 0.0 5.7e-72 242.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_M PF00373.16 NM_001146199.1_1 - 3.8e-21 75.5 2.4 9.5e-21 74.3 2.4 1.7 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.8 NM_001146199.1_1 - 2.9e-17 62.7 0.1 5.9e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_001146199.1_1 - 5.5e-16 58.1 0.5 1.3e-15 57.0 0.2 1.8 2 0 0 2 2 2 1 FERM N-terminal domain DSPc PF00782.18 NM_001146199.1_1 - 0.00042 20.0 0.0 0.00082 19.1 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_001146199.1_1 - 0.0039 17.0 0.0 0.0067 16.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family 7tm_1 PF00001.19 NM_001305392.1_1 - 1.7e-16 60.1 2.1 2.5e-16 59.6 2.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.19 NM_001305392.1_2 - 1.1e-31 110.0 4.9 1.6e-31 109.4 4.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 NM_001305392.1_2 - 0.00023 20.4 0.3 0.00036 19.8 0.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Orexin_rec2 PF03827.11 NM_001305392.1_2 - 0.018 14.9 0.8 0.035 14.0 0.8 1.4 1 0 0 1 1 1 0 Orexin receptor type 2 TP6A_N PF04406.12 NM_001305434.1_2 - 4e-25 87.4 0.1 7.3e-25 86.6 0.1 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase SPO11_like PF03533.12 NM_001305434.1_2 - 9.3e-24 83.1 4.5 1.6e-23 82.4 4.5 1.4 1 0 0 1 1 1 1 SPO11 homologue Y_phosphatase PF00102.25 NM_001252456.1_1 - 1.6e-165 548.1 0.1 4e-85 285.0 0.0 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.19 NM_001252456.1_1 - 1.5e-50 169.3 12.2 1e-14 54.5 2.7 5.5 5 0 0 5 5 5 4 Fibronectin type III domain I-set PF07679.14 NM_001252456.1_1 - 2.7e-41 139.4 0.0 2.6e-16 59.3 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001252456.1_1 - 4.1e-39 132.9 2.6 8.4e-12 45.4 0.0 5.5 5 0 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.4 NM_001252456.1_1 - 8.3e-23 80.4 0.1 5.9e-08 32.8 0.0 4.0 4 0 0 4 4 3 3 Immunoglobulin domain ig PF00047.23 NM_001252456.1_1 - 1.7e-16 60.0 0.0 0.00027 20.9 0.0 5.0 5 0 0 5 5 5 3 Immunoglobulin domain DSPc PF00782.18 NM_001252456.1_1 - 1.2e-08 34.7 0.0 0.0045 16.7 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain V-set PF07686.15 NM_001252456.1_1 - 6.4e-08 32.6 1.9 1.2 9.2 0.0 6.6 6 2 0 6 6 6 2 Immunoglobulin V-set domain Y_phosphatase3 PF13350.4 NM_001252456.1_1 - 5.6e-07 29.6 0.0 0.037 13.9 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_001252456.1_1 - 1.1e-05 25.5 0.0 0.0088 16.1 0.0 2.7 2 0 0 2 2 2 2 Inositol hexakisphosphate Pur_ac_phosph_N PF16656.3 NM_001252456.1_1 - 1.4e-05 25.5 9.6 0.87 10.1 1.3 6.0 5 2 0 5 5 5 2 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.10 NM_001252456.1_1 - 2.9e-05 23.9 0.0 1.3 9.0 0.0 3.7 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Interfer-bind PF09294.8 NM_001252456.1_1 - 0.0089 16.2 0.0 0.64 10.2 0.0 3.1 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Thymidylate_kin PF02223.15 NM_023136.2_3 - 6.6e-19 68.2 0.0 8.6e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase Dickkopf_N PF04706.10 NM_010051.3_1 - 2.8e-17 62.8 16.3 2.8e-17 62.8 16.3 3.1 3 1 0 3 3 3 2 Dickkopf N-terminal cysteine-rich region RRM_1 PF00076.20 NM_001029979.2_2 - 2e-13 49.8 0.0 4.3e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.25 NM_001029979.2_2 - 1.6e-11 43.6 2.1 2.2e-10 39.9 0.6 2.9 3 0 0 3 3 3 1 SAP domain RRM_5 PF13893.4 NM_001029979.2_2 - 0.0025 17.3 0.0 0.0049 16.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Exonuc_VII_L PF02601.13 NM_001029979.2_2 - 3.7 6.9 18.3 6.9 6.0 18.3 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Y_phosphatase PF00102.25 NM_001291149.1_3 - 2.7e-144 478.7 0.2 1e-78 264.0 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase MAM PF00629.21 NM_001291149.1_3 - 2.4e-27 95.6 0.0 4.6e-27 94.7 0.0 1.5 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu fn3 PF00041.19 NM_001291149.1_3 - 1e-25 89.7 2.9 2.5e-10 40.4 0.0 5.2 5 0 0 5 5 5 3 Fibronectin type III domain DSPc PF00782.18 NM_001291149.1_3 - 4e-07 29.8 0.1 0.03 14.0 0.1 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_001291149.1_3 - 0.00052 19.9 0.0 0.065 13.0 0.0 2.2 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_001291149.1_3 - 0.00096 19.2 0.0 1.6 8.7 0.0 2.4 2 0 0 2 2 2 2 Inositol hexakisphosphate EphA2_TM PF14575.4 NM_001291149.1_3 - 0.091 13.4 0.0 0.29 11.8 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain BAF250_C PF12031.6 NM_001080819.1_1 - 2.6e-114 380.7 0.1 3.9e-114 380.1 0.1 1.3 1 0 0 1 1 1 1 SWI/SNF-like complex subunit BAF250/Osa ARID PF01388.19 NM_001080819.1_1 - 1.8e-14 54.0 0.1 3.7e-14 53.0 0.1 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain GCFC PF07842.10 NM_177884.3_3 - 3.1e-31 108.9 0.7 7.4e-30 104.4 0.7 2.3 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein IMD PF08397.9 NM_177884.3_3 - 4 6.6 10.9 4.2 6.6 1.5 2.6 1 1 1 2 2 2 0 IRSp53/MIM homology domain Tubulin PF00091.23 NM_001080971.2_1 - 8.5e-70 234.8 0.0 1.2e-69 234.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_001080971.2_1 - 5.9e-41 139.5 0.0 9.2e-41 138.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 NM_001080971.2_1 - 7.6e-05 22.9 0.0 0.00021 21.4 0.0 1.6 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.4 NM_001080971.2_1 - 0.0036 16.4 0.0 0.0058 15.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.4 NM_001080971.2_1 - 0.016 14.7 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain ART PF01129.16 NM_001080971.2_1 - 0.13 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase TPR_11 PF13414.4 NM_177625.4_3 - 4.6e-05 22.9 0.0 0.00012 21.6 0.0 1.7 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.15 NM_177625.4_3 - 7.9e-05 22.4 0.0 0.0023 17.8 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_177625.4_3 - 0.00062 20.3 0.0 0.09 13.4 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_177625.4_3 - 0.0081 16.2 0.1 0.062 13.4 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.26 NM_177625.4_3 - 0.0096 15.6 0.1 0.14 11.9 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_177625.4_3 - 0.035 14.5 0.0 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.4 NM_177625.4_3 - 0.045 14.0 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.4 NM_177625.4_3 - 0.11 13.3 0.0 0.9 10.4 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat PseudoU_synth_1 PF01416.18 NM_001033490.1_2 - 2.7e-33 114.5 0.0 8.5e-25 87.2 0.0 2.2 2 0 0 2 2 2 2 tRNA pseudouridine synthase Homeobox PF00046.27 NM_008936.1_1 - 1.2e-22 79.4 1.6 2.3e-22 78.4 1.6 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_008936.1_1 - 0.00071 19.3 0.2 0.0019 17.9 0.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain MRP-L20 PF12824.5 NM_008936.1_1 - 0.1 12.7 0.1 0.1 12.7 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal protein subunit L20 FAM27 PF15832.3 NM_008936.1_2 - 0.19 12.1 16.6 0.37 11.2 16.6 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family Pkinase PF00069.23 NM_001145803.1_1 - 2.8e-79 266.1 0.0 3.6e-79 265.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001145803.1_1 - 7.2e-36 123.7 0.3 2.4e-35 121.9 0.3 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase SRCR PF00530.16 NM_007650.3_3 - 1.5e-19 70.2 25.5 3.1e-09 37.1 6.9 3.8 3 1 0 3 3 3 3 Scavenger receptor cysteine-rich domain Comm PF15957.3 NM_007650.3_3 - 0.015 15.5 0.0 0.034 14.3 0.0 1.5 1 0 0 1 1 1 0 Commissureless Afaf PF15339.4 NM_007650.3_3 - 0.17 11.5 0.1 0.29 10.7 0.1 1.3 1 0 0 1 1 1 0 Acrosome formation-associated factor BCOR PF15808.3 NM_175046.3_2 - 1.3e-74 251.0 19.2 4.5e-74 249.2 19.2 2.0 1 0 0 1 1 1 1 BCL-6 co-repressor, non-ankyrin-repeat region PUFD PF16553.3 NM_175046.3_2 - 6e-51 171.3 1.2 1.2e-50 170.3 1.2 1.5 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain Ank_2 PF12796.5 NM_175046.3_2 - 7.4e-16 58.4 0.6 3.6e-15 56.2 0.4 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_175046.3_2 - 7.7e-14 50.3 1.4 8.8e-05 22.5 0.2 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.4 NM_175046.3_2 - 1.6e-12 47.3 4.6 2.7e-09 37.0 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_175046.3_2 - 2.4e-11 43.8 6.9 1.6e-06 28.4 0.4 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_175046.3_2 - 9.7e-10 38.3 1.2 0.0017 18.6 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeat EamA PF00892.18 NM_019871.2_2 - 4.2e-09 36.6 25.4 6.2e-05 23.1 4.0 2.3 2 1 0 2 2 2 2 EamA-like transporter family 2-oxoacid_dh PF00198.21 NM_145614.4_3 - 1.6e-79 266.5 0.1 2e-79 266.2 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 NM_145614.4_3 - 2.9e-31 107.0 1.0 1.2e-14 53.7 0.1 2.3 2 0 0 2 2 2 2 Biotin-requiring enzyme E3_binding PF02817.15 NM_145614.4_3 - 7.3e-16 58.1 0.8 1.5e-15 57.1 0.3 1.9 1 1 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.4 NM_145614.4_3 - 0.00015 21.4 0.0 0.068 12.9 0.0 2.5 2 0 0 2 2 2 2 Biotin-lipoyl like ECSCR PF15820.3 NM_001033141.1_1 - 2.2e-56 187.9 4.7 3.8e-56 187.1 4.7 1.4 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.4 NM_001033141.1_1 - 0.015 16.0 0.0 0.034 14.8 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Rifin_STEVOR PF02009.14 NM_001033141.1_1 - 0.13 12.0 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Rifin/stevor family Suf PF05843.12 NM_001033141.1_1 - 0.18 11.6 1.5 0.25 11.1 1.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4834 PF16118.3 NM_001033141.1_1 - 0.54 11.1 0.1 0.54 11.1 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Miga PF10265.7 NM_001033141.1_1 - 0.6 8.9 2.9 2.9 6.6 1.2 2.0 1 1 1 2 2 2 0 Mitoguardin TMEM154 PF15102.4 NM_001033141.1_1 - 8.8 6.1 12.7 3.5 7.4 6.4 2.7 1 1 1 2 2 2 0 TMEM154 protein family V-set PF07686.15 NM_001162523.1_1 - 1.6e-13 50.6 0.0 8.5e-08 32.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001162523.1_1 - 6.9e-08 32.9 0.0 8e-06 26.3 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 NM_001162523.1_1 - 5.6e-06 26.2 0.0 0.00023 21.0 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 NM_001162523.1_1 - 0.037 14.1 0.1 4.2 7.5 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin domain Receptor_2B4 PF11465.6 NM_001162523.1_1 - 0.043 13.9 0.0 0.2 11.8 0.0 2.0 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 7tm_4 PF13853.4 NM_207133.2_2 - 5.4e-55 187.0 16.4 8e-55 186.4 16.4 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207133.2_2 - 1.5e-19 70.2 20.8 1.5e-19 70.2 20.8 2.0 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Palm_thioest PF02089.13 NM_008917.3_3 - 4.4e-204 675.5 0.3 5.5e-204 675.2 0.3 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Hormone_recep PF00104.28 NM_013708.4_1 - 9.8e-32 110.1 0.0 1.5e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_013708.4_1 - 5.9e-27 93.8 14.6 1.3e-26 92.6 13.8 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) C1_2 PF03107.14 NM_013708.4_1 - 3.2 8.0 8.0 0.61 10.3 0.8 2.5 2 0 0 2 2 2 0 C1 domain LAP1C PF05609.10 NM_001160019.1_2 - 1e-166 555.5 6.2 9.1e-162 539.1 0.8 2.0 1 1 1 2 2 2 2 Lamina-associated polypeptide 1C (LAP1C) V-set PF07686.15 NM_178796.6_3 - 4.9e-14 52.3 0.5 8.3e-14 51.5 0.5 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_178796.6_3 - 0.097 13.2 0.2 0.27 11.7 0.2 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Tubulin PF00091.23 NM_023279.2_1 - 2.3e-69 233.4 0.0 3.4e-69 232.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_023279.2_1 - 4.2e-42 143.2 0.1 6.5e-42 142.6 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 NM_023279.2_1 - 3.2e-06 27.3 0.0 8.3e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 NM_023279.2_1 - 0.021 14.4 0.0 0.039 13.5 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 NM_023279.2_1 - 0.065 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Tubulin like PI-PLC-X PF00388.17 NM_019588.2_3 - 7.5e-59 197.4 0.0 1.8e-58 196.1 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 NM_019588.2_3 - 8.5e-35 119.5 0.0 6.7e-33 113.4 0.0 2.7 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain RasGEF PF00617.17 NM_019588.2_3 - 4.7e-22 78.8 0.1 9e-22 77.9 0.1 1.4 1 0 0 1 1 1 1 RasGEF domain RA PF00788.21 NM_019588.2_3 - 1.3e-20 73.7 0.6 6.2e-20 71.5 0.2 2.3 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain C2 PF00168.28 NM_019588.2_3 - 1.4e-08 34.9 0.0 2.5e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.9 NM_019588.2_3 - 0.00015 22.1 0.0 0.00059 20.1 0.0 2.0 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like Use1 PF09753.7 NM_025917.4_1 - 8.1e-92 307.3 8.2 9.3e-92 307.1 8.2 1.0 1 0 0 1 1 1 1 Membrane fusion protein Use1 MCU PF04678.11 NM_025917.4_1 - 0.0019 18.2 7.6 0.0054 16.7 7.2 2.0 1 1 0 1 1 1 1 Mitochondrial calcium uniporter Collectrin PF16959.3 NM_025917.4_1 - 0.014 15.0 0.1 0.022 14.3 0.1 1.2 1 0 0 1 1 1 0 Renal amino acid transporter Amnionless PF14828.4 NM_025917.4_1 - 0.024 13.3 0.1 0.035 12.8 0.1 1.1 1 0 0 1 1 1 0 Amnionless CCB2_CCB4 PF11152.6 NM_025917.4_1 - 0.045 12.9 0.8 0.081 12.1 0.5 1.6 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 AAR2 PF05282.9 NM_025917.4_1 - 0.085 12.1 2.1 1.8 7.7 0.0 2.1 2 0 0 2 2 2 0 AAR2 protein DUF912 PF06024.10 NM_025917.4_1 - 0.094 12.9 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) SapB_1 PF05184.13 NM_011179.3_2 - 3.4e-41 138.6 20.6 6.5e-14 51.5 1.3 5.1 4 0 0 4 4 4 4 Saposin-like type B, region 1 SapB_2 PF03489.15 NM_011179.3_2 - 3.4e-35 119.7 33.9 2.1e-10 40.4 0.3 7.0 7 0 0 7 7 7 4 Saposin-like type B, region 2 SapA PF02199.13 NM_011179.3_2 - 8.1e-29 99.4 26.7 2.8e-17 62.4 9.4 4.0 4 0 0 4 4 4 2 Saposin A-type domain Ion_trans PF00520.29 NM_013568.6_1 - 1.7e-49 168.2 1.1 2.5e-49 167.6 1.1 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_013568.6_1 - 4e-26 91.1 0.0 6.2e-26 90.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_013568.6_1 - 8.5e-12 44.8 7.0 8.5e-12 44.8 7.0 2.1 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.10 NM_013568.6_1 - 0.047 12.2 2.8 0.085 11.4 2.8 1.4 1 1 0 1 1 1 0 Polycystin cation channel SCA7 PF08313.10 NM_001033436.3_3 - 4.4e-28 96.8 2.6 1.1e-27 95.6 2.6 1.7 1 0 0 1 1 1 1 SCA7, zinc-binding domain SET PF00856.26 NM_001290716.1_3 - 2.2e-23 83.4 0.2 3.9e-23 82.5 0.2 1.4 1 0 0 1 1 1 1 SET domain Pre-SET PF05033.14 NM_001290716.1_3 - 9.3e-17 61.5 4.4 9.3e-17 61.5 4.4 2.3 3 0 0 3 3 3 1 Pre-SET motif Chromo PF00385.22 NM_001290716.1_3 - 8.8e-13 47.8 2.1 1.7e-12 46.9 2.1 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Ribonuc_L-PSP PF01042.19 NM_008287.3_1 - 6.3e-43 145.5 0.1 7.9e-43 145.2 0.1 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Corona_6B_7B PF03262.11 NM_008287.3_1 - 0.073 12.4 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Coronavirus 6B/7B protein Smg8_Smg9 PF10220.7 NM_024262.1_1 - 0 1153.7 0.0 0 1153.4 0.0 1.0 1 0 0 1 1 1 1 Smg8_Smg9 7tm_4 PF13853.4 NM_001011769.2_1 - 6.3e-50 170.3 10.4 7.8e-50 170.0 10.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011769.2_1 - 1.1e-23 83.7 10.2 2e-23 82.8 10.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 NM_001011769.2_1 - 0.0028 16.9 9.2 0.006 15.8 9.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 NM_001011769.2_1 - 0.0062 15.8 2.8 0.0062 15.8 2.8 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001011769.2_1 - 0.013 14.7 2.2 0.064 12.4 2.2 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Bd3614_N PF14442.4 NM_001011769.2_1 - 0.29 11.3 1.4 1.1 9.4 0.4 2.1 2 0 0 2 2 2 0 Bd3614-like deaminase N-terminal zf-H2C2_2 PF13465.4 NM_001256493.1_1 - 0.00013 22.1 3.3 0.00013 22.1 3.3 3.3 3 0 0 3 3 3 2 Zinc-finger double domain Katanin_con80 PF13925.4 NM_001256493.1_1 - 0.012 15.5 4.7 12 5.7 0.1 3.8 1 1 3 4 4 4 0 con80 domain of Katanin Phage_min_tail PF05939.11 NM_001256493.1_1 - 0.056 13.7 0.1 63 3.9 0.0 3.8 2 2 3 5 5 5 0 Phage minor tail protein zf-H2C2_2 PF13465.4 NM_001256493.1_3 - 1.8e-65 214.5 103.0 7.3e-09 35.6 2.7 12.0 13 0 0 13 13 13 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001256493.1_3 - 7.3e-42 139.4 98.9 1.3e-05 25.2 1.2 11.1 11 0 0 11 11 11 9 Zinc finger, C2H2 type KRAB PF01352.25 NM_001256493.1_3 - 5.4e-23 80.3 1.7 9.7e-23 79.5 1.7 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001256493.1_3 - 1.1e-20 72.4 90.1 0.0093 16.6 3.0 10.9 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001256493.1_3 - 1.2e-14 53.6 56.8 0.011 15.4 0.4 10.0 9 0 0 9 9 9 9 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 NM_001256493.1_3 - 4e-05 23.3 72.2 0.15 12.0 2.4 9.9 9 0 0 9 9 9 5 C2H2-type zinc finger C1_1 PF00130.20 NM_001256493.1_3 - 0.0018 18.0 62.9 0.022 14.5 4.5 8.2 3 1 7 10 10 10 6 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3850 PF12961.5 NM_001256493.1_3 - 0.01 15.9 0.5 50 4.1 0.0 4.8 3 1 4 7 7 7 0 Domain of Unknown Function with PDB structure (DUF3850) zf-met PF12874.5 NM_001256493.1_3 - 1.4 9.3 62.8 0.5 10.7 2.3 8.4 8 0 0 8 8 8 0 Zinc-finger of C2H2 type 7tm_4 PF13853.4 NM_207141.1_1 - 3.4e-46 158.1 28.8 4.2e-46 157.8 28.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207141.1_1 - 2.1e-19 69.7 28.4 3.7e-19 68.9 28.4 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_207141.1_1 - 0.0032 16.8 29.8 0.0065 15.7 29.8 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Iron_traffic PF04362.12 NM_025760.4_2 - 0.018 14.6 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial Fe(2+) trafficking PTPLA PF04387.12 NM_025760.4_3 - 6.8e-34 116.9 11.0 1.1e-33 116.2 11.0 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA UCH PF00443.27 NM_001038589.2_3 - 1.5e-49 168.7 0.8 2e-49 168.3 0.8 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001038589.2_3 - 1.7e-14 54.0 4.1 3.2e-14 53.1 4.1 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.21 NM_001038589.2_3 - 0.051 13.2 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family UQ_con PF00179.24 NM_001276396.1_1 - 7.5e-52 174.6 0.1 9.6e-52 174.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 NM_001276396.1_1 - 0.015 15.5 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 RWD domain Tho2 PF11262.6 NM_001166581.1_1 - 5e-101 337.7 5.2 5e-101 337.7 5.2 4.5 6 0 0 6 6 6 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.3 NM_001166581.1_1 - 6.5e-88 295.8 5.2 1.9e-61 208.4 1.9 4.3 3 1 1 4 4 4 2 THO complex subunit 2 N-terminus Thoc2 PF11732.6 NM_001166581.1_1 - 1e-36 124.7 0.2 5.6e-36 122.3 0.2 2.3 2 0 0 2 2 2 1 Transcription- and export-related complex subunit I-set PF07679.14 NM_001081390.1_3 - 2.4e-113 370.3 0.0 3.1e-23 81.5 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001081390.1_3 - 3.7e-76 251.6 0.1 6e-14 52.3 0.0 5.9 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 NM_001081390.1_3 - 1.2e-53 179.2 0.5 4e-10 39.8 0.0 5.7 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 NM_001081390.1_3 - 3.2e-51 171.3 3.6 2.5e-10 40.3 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.15 NM_001081390.1_3 - 1.6e-22 79.6 5.2 0.0014 18.6 0.0 8.4 5 4 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001081390.1_3 - 2.2e-19 69.2 0.8 0.022 14.7 0.1 6.0 5 1 0 5 5 5 5 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_001081390.1_3 - 4.4e-09 36.6 0.4 1.1 9.7 0.0 5.4 5 0 0 5 5 5 3 Immunoglobulin C1-set domain Receptor_2B4 PF11465.6 NM_001081390.1_3 - 7.9e-05 22.7 0.0 0.38 10.9 0.0 4.7 5 0 0 5 5 5 1 Natural killer cell receptor 2B4 CG-1 PF03859.14 NM_001081557.3_1 - 3.6e-42 142.7 2.8 7e-42 141.8 2.8 1.5 1 0 0 1 1 1 1 CG-1 domain TIG PF01833.22 NM_001081557.3_1 - 1.3e-10 41.0 0.2 5.3e-10 39.1 0.1 2.1 2 0 0 2 2 2 1 IPT/TIG domain Ank_2 PF12796.5 NM_001081557.3_1 - 2.2e-09 37.6 0.2 4.8e-05 23.7 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_001081557.3_1 - 3.6e-05 23.9 0.1 0.54 10.6 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) IQ PF00612.25 NM_001081557.3_1 - 0.00042 19.7 12.9 1.1 9.1 0.2 4.8 4 0 0 4 4 4 3 IQ calmodulin-binding motif Ank_3 PF13606.4 NM_001081557.3_1 - 0.00086 19.5 0.6 1.9 9.2 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 NM_001081557.3_1 - 0.0013 19.2 0.5 0.078 13.5 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 NM_001081557.3_1 - 0.035 14.5 0.3 6.4 7.3 0.1 2.7 2 0 0 2 2 2 0 Ankyrin repeat HCO3_cotransp PF00955.19 NM_001166067.1_1 - 7.6e-224 744.2 6.8 9.6e-224 743.8 6.8 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 NM_001166067.1_1 - 2.3e-104 348.8 0.0 3.6e-104 348.2 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Xan_ur_permease PF00860.18 NM_001166067.1_1 - 0.07 11.7 7.8 0.3 9.6 0.7 2.4 2 0 0 2 2 2 0 Permease family DUF4519 PF15012.4 NM_001166067.1_1 - 1.6 8.8 3.4 4.5 7.4 3.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) Alpha_E3_glycop PF01563.14 NM_001166067.1_2 - 0.029 14.3 4.3 0.078 12.9 4.3 1.7 1 0 0 1 1 1 0 Alphavirus E3 glycoprotein Paxillin PF03535.11 NM_011223.3_1 - 1.1e-93 312.7 17.9 1.1e-93 312.7 17.9 1.6 2 0 0 2 2 2 1 Paxillin family LIM PF00412.20 NM_011223.3_1 - 4.3e-65 215.7 37.3 9.1e-18 64.1 1.9 4.4 4 0 0 4 4 4 4 LIM domain VIR_N PF15912.3 NM_011223.3_1 - 1.5 8.3 4.0 4.6 6.7 4.0 1.8 1 0 0 1 1 1 0 Virilizer, N-terminal CtaG_Cox11 PF04442.12 NM_199008.2_1 - 6.7e-62 207.8 0.4 9.4e-62 207.4 0.4 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 UCR_Fe-S_N PF10399.7 NM_199008.2_1 - 0.015 14.5 0.2 0.033 13.4 0.2 1.5 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Fox-1_C PF12414.6 NM_199008.2_3 - 0.13 12.5 0.6 0.22 11.7 0.6 1.3 1 0 0 1 1 1 0 Calcitonin gene-related peptide regulator C terminal COX17 PF05051.11 NM_001017429.2_1 - 4.7e-21 74.7 6.8 6.7e-21 74.3 6.8 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CPCFC PF17223.1 NM_001310456.1_1 - 0.14 11.8 2.8 0.43 10.3 2.8 1.9 1 0 0 1 1 1 0 Cuticle protein CPCFC Pkinase PF00069.23 NM_001310456.1_3 - 6.4e-70 235.4 0.0 9.6e-70 234.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001310456.1_3 - 5.1e-34 117.6 0.0 7.5e-34 117.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001310456.1_3 - 1.2e-05 24.7 0.0 1.7e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001310456.1_3 - 0.0043 16.3 0.2 0.0081 15.4 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.9 NM_001310456.1_3 - 0.15 11.0 0.1 0.31 9.9 0.0 1.4 2 0 0 2 2 2 0 Seadornavirus VP7 fn3 PF00041.19 NM_001081432.1_3 - 5.5e-161 523.2 62.2 1.4e-14 54.1 0.6 19.4 19 0 0 19 19 19 18 Fibronectin type III domain Y_phosphatase PF00102.25 NM_001081432.1_3 - 9e-76 254.4 0.0 2.3e-75 253.1 0.0 1.8 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pur_ac_phosph_N PF16656.3 NM_001081432.1_3 - 1.1e-21 77.0 57.6 8.2e-05 23.0 0.0 16.8 15 4 0 15 15 15 6 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 NM_001081432.1_3 - 1.3e-10 41.4 2.4 4.6 7.5 0.0 10.7 12 0 0 12 12 12 2 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.3 NM_001081432.1_3 - 0.00013 21.9 16.4 0.58 10.2 0.0 10.0 11 1 0 11 11 11 1 Fibronectin type III domain Y_phosphatase3 PF13350.4 NM_001081432.1_3 - 0.00082 19.3 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family CBM_4_9 PF02018.15 NM_001081432.1_3 - 0.0047 17.0 0.6 4.6 7.3 0.0 5.6 6 0 0 6 6 6 1 Carbohydrate binding domain SusE PF14292.4 NM_001081432.1_3 - 0.04 14.2 16.1 4.8 7.5 0.3 7.9 9 1 2 11 11 11 0 SusE outer membrane protein DSPc PF00782.18 NM_001081432.1_3 - 0.086 12.5 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 NM_001081432.1_3 - 0.11 12.6 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Myosin_head PF00063.19 NM_001161817.2_3 - 6.2e-265 880.5 5.4 8.2e-265 880.1 5.4 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 NM_001161817.2_3 - 1.4e-42 145.3 3.6 1.4e-42 145.3 3.6 2.6 3 0 0 3 3 3 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 NM_001161817.2_3 - 8.9e-08 31.1 30.7 0.00035 20.0 0.8 6.7 6 0 0 6 6 6 3 IQ calmodulin-binding motif AAA_16 PF13191.4 NM_001161817.2_3 - 0.012 15.8 0.3 0.04 14.2 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain Hpr_kinase_C PF07475.10 NM_001161817.2_3 - 0.036 13.5 0.9 3 7.2 0.0 2.6 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain RNA_pol PF00940.17 NM_001161817.2_3 - 0.036 12.7 0.6 0.072 11.8 0.6 1.4 1 0 0 1 1 1 0 DNA-dependent RNA polymerase AAA_22 PF13401.4 NM_001161817.2_3 - 0.046 13.9 0.0 0.16 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain EGF PF00008.25 NM_032002.2_3 - 0.0035 17.5 5.7 0.0094 16.1 5.7 1.8 1 0 0 1 1 1 1 EGF-like domain Sulfotransfer_1 PF00685.25 NM_001252072.1_1 - 8.9e-43 146.5 0.0 1.2e-42 146.1 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_001252072.1_1 - 1.3e-12 48.5 0.0 5.9e-09 36.5 0.0 2.4 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.12 NM_001252072.1_1 - 0.082 12.7 0.0 0.36 10.6 0.0 1.8 2 0 0 2 2 2 0 Sulfotransferase family Yae1_N PF09811.7 NM_001252072.1_2 - 5.1 6.8 15.0 5.4 6.7 4.6 2.4 2 0 0 2 2 2 0 Essential protein Yae1, N terminal Yae1_N PF09811.7 NM_001252072.1_3 - 2.3 7.8 10.0 4.7 6.9 0.8 2.6 2 0 0 2 2 2 0 Essential protein Yae1, N terminal IGFBP PF00219.16 NM_018865.2_3 - 6.6e-09 36.2 20.1 6.6e-09 36.2 20.1 4.8 5 1 0 5 5 5 1 Insulin-like growth factor binding protein VWC PF00093.16 NM_018865.2_3 - 1.6e-07 31.4 11.5 1.6e-07 31.4 11.5 5.9 6 0 0 6 6 6 1 von Willebrand factor type C domain TSP_1 PF00090.17 NM_018865.2_3 - 8.1e-06 25.8 5.1 3.9e-05 23.6 5.1 2.2 1 0 0 1 1 1 1 Thrombospondin type 1 domain Hormone_6 PF00236.16 NM_130453.3_3 - 8.3e-05 22.4 5.8 0.00015 21.5 5.8 1.5 1 1 0 1 1 1 1 Glycoprotein hormone Cys_knot PF00007.20 NM_130453.3_3 - 0.0012 18.9 6.7 0.0022 18.1 6.7 1.5 1 0 0 1 1 1 1 Cystine-knot domain Mito_carr PF00153.25 NM_001290705.1_3 - 1.1e-66 220.6 1.0 1.5e-21 76.0 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein 7tm_4 PF13853.4 NM_001012266.1_1 - 4.8e-47 160.9 24.7 6.1e-47 160.5 24.7 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001012266.1_1 - 1.3e-23 83.4 23.1 2.8e-23 82.4 23.1 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001012266.1_1 - 2e-06 27.3 20.3 2e-06 27.3 20.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Keratin_matx PF04579.10 NM_025524.2_1 - 4.1e-46 155.1 40.4 4.1e-46 155.1 40.4 1.5 2 0 0 2 2 2 1 Keratin, high-sulphur matrix protein Lys PF00062.18 NM_017372.3_1 - 5.5e-56 188.0 4.2 8.5e-56 187.4 4.2 1.3 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.18 NM_017372.3_1 - 0.00039 19.9 0.0 0.00062 19.3 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain Lectin_C PF00059.19 NM_181549.3_2 - 1.1e-17 64.5 0.7 1.1e-17 64.5 0.7 2.4 3 0 0 3 3 3 1 Lectin C-type domain CAP PF00188.24 NM_181549.3_2 - 1.9e-17 64.2 1.8 3.4e-17 63.3 1.1 1.8 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Asp_Glu_race_2 PF14669.4 NM_001199736.1_1 - 3.4e-154 510.7 0.3 6.6e-154 509.8 0.3 1.5 1 0 0 1 1 1 1 Putative aspartate racemase DUF4721 PF15848.3 NM_001199736.1_1 - 0.044 14.1 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4721) Striatin PF08232.10 NM_052973.2_2 - 1.7e-48 165.0 5.4 4.5e-48 163.6 5.4 1.8 1 1 0 1 1 1 1 Striatin family WD40 PF00400.30 NM_052973.2_2 - 8.8e-34 114.9 11.2 6.1e-08 33.1 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_052973.2_2 - 2.3e-06 27.7 0.1 0.22 11.7 0.0 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_052973.2_2 - 0.00099 17.7 0.0 1.2 7.6 0.0 2.7 3 0 0 3 3 3 2 Nucleoporin Nup120/160 DUF4482 PF14818.4 NM_052973.2_2 - 0.1 13.3 3.1 0.33 11.7 3.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) DNA_ligase_A_M PF01068.19 NM_010715.2_3 - 5.8e-67 225.1 0.3 1e-66 224.4 0.3 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 NM_010715.2_3 - 4.3e-39 134.5 0.0 9.3e-39 133.4 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.13 NM_010715.2_3 - 2.9e-25 88.6 0.0 1.5e-24 86.3 0.0 2.3 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DDR PF08841.8 NM_010715.2_3 - 0.0038 16.1 0.2 0.013 14.4 0.1 1.8 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain DNA_ligase_OB_2 PF14743.4 NM_010715.2_3 - 0.012 15.5 0.3 2.4 8.2 0.0 2.6 2 0 0 2 2 2 0 DNA ligase OB-like domain PucR PF07905.9 NM_010715.2_3 - 0.016 15.3 0.0 0.052 13.7 0.0 1.8 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family HTH_43 PF09904.7 NM_010715.2_3 - 0.026 14.3 0.0 6.5 6.6 0.0 2.4 2 0 0 2 2 2 0 Winged helix-turn helix DDHD PF02862.15 NM_019569.2_1 - 0.0075 16.3 9.6 0.0094 16.0 9.6 1.1 1 0 0 1 1 1 1 DDHD domain DUF1510 PF07423.9 NM_019569.2_1 - 0.075 12.3 27.8 0.097 12.0 27.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Zip PF02535.20 NM_019569.2_1 - 0.24 10.5 15.9 0.34 10.0 15.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF789 PF05623.10 NM_019569.2_1 - 0.3 10.6 11.5 0.41 10.2 11.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF789) NPR3 PF03666.11 NM_019569.2_1 - 1.6 7.3 31.8 2.1 6.9 31.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2052 PF09747.7 NM_019569.2_1 - 1.7 8.6 17.7 2.2 8.3 17.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RNA_pol_Rpc4 PF05132.12 NM_019569.2_1 - 5.4 7.3 31.0 10 6.4 31.0 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Fascin PF06268.11 NM_019569.2_2 - 1.8e-61 205.1 0.1 1.1e-26 93.2 0.1 4.8 4 1 0 4 4 4 4 Fascin domain FRG1 PF06229.10 NM_019569.2_2 - 4e-05 23.3 38.0 0.17 11.4 0.0 6.2 4 2 2 6 6 6 5 FRG1-like domain DDHD PF02862.15 NM_019569.2_3 - 1.5 8.8 20.2 2.1 8.3 20.2 1.2 1 0 0 1 1 1 0 DDHD domain Ribosomal_60s PF00428.17 NM_026020.6_3 - 6.7e-26 90.5 7.8 8.7e-26 90.2 7.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Glyco_tranf_2_3 PF13641.4 NM_008216.3_2 - 1.1e-18 67.8 0.1 1e-14 54.9 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.13 NM_008216.3_2 - 4.5e-18 65.0 2.7 1e-14 54.0 0.4 3.0 2 1 0 2 2 2 2 Chitin synthase Glycos_transf_2 PF00535.24 NM_008216.3_2 - 7.9e-09 35.4 0.0 9.3e-05 22.2 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.4 NM_008216.3_2 - 2.1e-08 34.2 5.6 2.1e-08 34.2 5.6 2.1 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.4 NM_008216.3_2 - 0.013 14.8 0.0 0.026 13.9 0.0 1.5 1 1 0 1 1 1 0 Glycosyl transferase family 21 Reprolysin PF01421.17 NM_033615.3_1 - 3.2e-61 206.6 0.0 5.9e-61 205.7 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_033615.3_1 - 2e-29 102.2 0.4 2e-29 102.2 0.4 3.2 3 0 0 3 3 1 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 NM_033615.3_1 - 1e-22 80.7 0.0 2.2e-22 79.7 0.0 1.5 2 0 0 2 2 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_033615.3_1 - 2.8e-20 73.2 0.0 5.3e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 NM_033615.3_1 - 5e-19 68.8 25.8 5e-19 68.8 25.8 3.7 4 1 0 4 4 2 1 Disintegrin Reprolysin_3 PF13582.4 NM_033615.3_1 - 2.5e-15 56.9 0.0 4.6e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_033615.3_1 - 3.6e-11 43.2 0.0 5.7e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_033615.3_1 - 6.5e-07 29.1 0.0 1e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 NM_033615.3_1 - 0.034 13.9 0.0 0.053 13.2 0.0 1.2 1 0 0 1 1 1 0 Matrixin Peptidase_M43 PF05572.11 NM_033615.3_1 - 0.053 13.3 0.2 0.11 12.2 0.2 1.4 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A DUF4953 PF16313.3 NM_033615.3_1 - 0.28 10.2 0.5 0.43 9.6 0.5 1.1 1 0 0 1 1 1 0 Met-zincin Peptidase_M54 PF07998.9 NM_033615.3_1 - 0.31 10.9 0.4 0.55 10.0 0.4 1.3 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M66 PF10462.7 NM_033615.3_1 - 0.42 9.4 0.9 0.63 8.8 0.9 1.1 1 0 0 1 1 1 0 Peptidase M66 Metallopep PF12044.6 NM_033615.3_1 - 0.96 7.9 2.5 1.3 7.4 2.5 1.1 1 0 0 1 1 1 0 Putative peptidase family SMC_N PF02463.17 NM_001301412.1_3 - 1.8e-54 184.4 47.5 3.2e-53 180.3 47.5 3.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 NM_001301412.1_3 - 1.9e-22 79.6 0.4 1.9e-22 79.6 0.4 2.0 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.4 NM_001301412.1_3 - 5.8e-10 39.3 10.0 5.1e-05 23.1 0.7 3.0 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system ATG16 PF08614.9 NM_001301412.1_3 - 0.00029 21.0 30.9 0.00029 21.0 30.9 6.0 3 2 3 6 6 6 2 Autophagy protein 16 (ATG16) AAA_29 PF13555.4 NM_001301412.1_3 - 0.00097 18.7 0.0 0.0024 17.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.25 NM_001301412.1_3 - 0.018 15.4 0.1 0.018 15.4 0.1 6.2 5 2 1 6 6 6 0 ABC transporter 7tm_4 PF13853.4 NM_001011782.2_2 - 2.4e-69 234.0 19.8 2.9e-69 233.8 19.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011782.2_2 - 1.7e-14 53.6 16.2 2.8e-14 52.9 16.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011782.2_2 - 1.2e-07 31.3 12.2 3.7e-07 29.6 12.2 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DNA_ligase_A_N PF04675.12 NM_001011782.2_2 - 0.19 11.9 0.0 0.32 11.2 0.0 1.3 1 0 0 1 1 1 0 DNA ligase N terminus WH1 PF00568.21 NM_001282022.1_1 - 3.4e-36 123.4 0.0 5.5e-36 122.8 0.0 1.2 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 NM_001282022.1_1 - 2.4e-16 58.8 11.8 4.2e-16 58.1 11.8 1.4 1 0 0 1 1 1 1 VASP tetramerisation domain ASD2 PF08687.9 NM_001282022.1_1 - 0.025 14.0 3.7 0.035 13.6 3.7 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Ran_BP1 PF00638.16 NM_001282022.1_1 - 0.089 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 RanBP1 domain DUF4686 PF15742.3 NM_029286.2_2 - 4.5e-151 503.2 91.3 4.5e-151 503.2 91.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4686) Plant_tran PF04827.12 NM_029286.2_2 - 0.11 12.0 0.5 0.43 10.0 0.1 2.1 3 0 0 3 3 3 0 Plant transposon protein T7SS_ESX_EspC PF10824.6 NM_029286.2_2 - 0.13 12.6 0.6 1 9.7 0.0 2.7 2 1 1 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm Trypsin PF00089.24 NM_008693.2_3 - 2.1e-73 246.6 0.0 2.5e-73 246.4 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_008693.2_3 - 3.2e-07 31.2 0.0 5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_008693.2_3 - 8.1e-07 29.3 0.2 0.0014 18.8 0.5 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) DUF316 PF03761.13 NM_008693.2_3 - 0.056 12.9 0.0 1.9 7.8 0.0 2.1 2 0 0 2 2 2 0 Chymotrypsin family Peptidase-S1 PhoLip_ATPase_C PF16212.3 NM_029570.3_1 - 1.6e-78 263.8 35.4 1.6e-78 263.8 35.4 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 NM_029570.3_1 - 1.4e-21 75.8 3.5 1.4e-21 75.8 3.5 2.8 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.24 NM_029570.3_1 - 1.2e-13 51.7 0.2 1.7e-08 34.9 0.1 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.4 NM_029570.3_1 - 3.5e-11 42.9 0.0 1.7e-10 40.7 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.18 NM_029570.3_1 - 8.2e-11 41.5 0.3 8.2e-11 41.5 0.3 2.4 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.10 NM_029570.3_1 - 0.0013 18.4 0.0 0.029 14.0 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ion_trans PF00520.29 NM_001271704.1_3 - 1.4e-41 142.2 3.9 1.4e-41 142.2 3.9 1.6 2 0 0 2 2 2 1 Ion transport protein BTB_2 PF02214.20 NM_001271704.1_3 - 2.9e-29 101.1 0.2 1e-28 99.4 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_001271704.1_3 - 3.7e-13 49.1 4.1 1.1e-12 47.6 4.1 1.9 1 0 0 1 1 1 1 Ion channel DUF3915 PF13054.4 NM_001082960.1_1 - 0.0061 16.4 6.6 0.011 15.6 6.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 NM_001082960.1_1 - 0.075 11.2 11.8 0.12 10.5 11.8 1.2 1 0 0 1 1 1 0 Atrophin-1 family VWA PF00092.26 NM_001082960.1_2 - 4.2e-43 147.5 0.5 6.3e-43 146.9 0.5 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_alpha2 PF08441.10 NM_001082960.1_2 - 2.5e-38 132.0 0.1 2.5e-38 132.0 0.1 1.7 2 0 0 2 2 2 1 Integrin alpha FG-GAP PF01839.21 NM_001082960.1_2 - 2.1e-20 72.3 2.1 1e-08 35.0 0.9 3.8 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 NM_001082960.1_2 - 2.6e-15 56.9 0.0 5.3e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_alpha PF00357.18 NM_001082960.1_2 - 2.6e-05 23.7 0.9 7.8e-05 22.2 0.9 1.9 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region VCBS PF13517.4 NM_001082960.1_2 - 0.00014 22.3 0.1 0.35 11.4 0.1 3.4 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 NM_001082960.1_2 - 0.0028 17.7 6.5 0.84 9.8 0.0 4.5 5 0 0 5 5 5 2 FG-GAP repeat DUF3915 PF13054.4 NM_001082960.1_2 - 1.4 8.8 10.9 6.1 6.7 10.9 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 NM_001082960.1_2 - 1.6 6.8 14.4 2.9 5.9 14.4 1.3 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 NM_001082960.1_3 - 0.0011 18.8 6.4 0.0021 17.9 6.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 NM_001082960.1_3 - 0.12 10.6 15.2 0.16 10.1 15.2 1.1 1 0 0 1 1 1 0 Atrophin-1 family Carb_anhydrase PF00194.19 NM_007608.2_3 - 5.1e-85 284.9 0.0 6.5e-85 284.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Proteasome PF00227.24 NM_013640.3_2 - 2.3e-47 160.8 0.0 3e-47 160.5 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.6 NM_013640.3_2 - 5.4e-14 51.2 0.5 1.1e-13 50.2 0.5 1.5 1 0 0 1 1 1 1 Proteasome beta subunits C terminal 7tm_4 PF13853.4 NM_146277.1_1 - 2.2e-46 158.7 13.8 2.7e-46 158.4 13.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146277.1_1 - 3.2e-26 92.0 6.6 4.2e-26 91.7 6.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146277.1_1 - 0.0011 18.3 18.1 0.0016 17.7 18.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Cyclin_N PF00134.21 NM_146277.1_1 - 0.017 14.8 0.4 0.031 13.9 0.4 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Basic PF01586.14 NM_008657.2_2 - 1.2e-22 80.8 0.0 2.8e-22 79.5 0.0 1.7 1 0 0 1 1 1 1 Myogenic Basic domain HLH PF00010.24 NM_008657.2_2 - 1.3e-12 47.4 5.8 1.3e-12 47.4 5.8 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Myf5 PF12232.6 NM_008657.2_2 - 0.0025 18.4 0.4 0.0025 18.4 0.4 1.9 2 0 0 2 2 2 1 Myogenic determination factor 5 adh_short PF00106.23 NM_183286.2_3 - 4.4e-31 107.7 0.0 5.3e-30 104.2 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_183286.2_3 - 2.3e-22 79.6 0.0 1.7e-21 76.7 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_183286.2_3 - 1.1e-08 35.0 0.0 1.7e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 NM_183286.2_3 - 3.4e-05 23.3 0.0 4.7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PEPCK PF00821.16 NM_011044.2_3 - 2.5e-274 910.9 0.0 2.9e-274 910.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase 7tm_1 PF00001.19 NM_181753.4_2 - 1e-39 136.3 9.4 1.4e-39 135.8 9.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SOCS_box PF07525.14 NM_181753.4_3 - 0.9 9.8 3.7 6.7 7.0 0.6 2.5 2 0 0 2 2 2 0 SOCS box 7tm_2 PF00002.22 NM_021332.2_2 - 2.8e-81 272.3 19.7 4.1e-81 271.7 19.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_021332.2_2 - 7.8e-17 61.2 2.7 2.5e-16 59.6 2.7 2.0 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.9 NM_021332.2_2 - 0.008 15.2 15.2 0.014 14.4 15.2 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor WD40 PF00400.30 NM_201357.2_1 - 2.5e-16 59.6 9.6 2.3e-05 24.9 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat Mon2_C PF16206.3 NM_153395.2_1 - 0 1335.6 0.5 0 1334.6 0.7 1.3 2 0 0 2 2 2 1 C-terminal region of Mon2 protein DCB PF16213.3 NM_153395.2_1 - 3.1e-69 232.0 7.8 1e-68 230.4 7.8 2.0 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.5 NM_153395.2_1 - 4.2e-54 182.7 2.7 4.2e-54 182.7 2.7 2.5 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.8 NM_153395.2_1 - 1.8e-18 66.0 0.2 1.7e-16 59.7 0.0 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) HEAT PF02985.20 NM_153395.2_1 - 0.0029 17.6 1.3 40 4.7 0.0 5.0 4 0 0 4 4 4 0 HEAT repeat Pkinase_Tyr PF07714.15 NM_019392.2_1 - 1e-89 300.2 0.0 1.3e-89 299.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_019392.2_1 - 6.9e-37 127.1 0.0 9.8e-37 126.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.4 NM_019392.2_1 - 5.3e-20 71.7 0.1 1.1e-11 45.1 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_019392.2_1 - 4.1e-16 58.7 0.6 1e-13 51.0 0.2 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_019392.2_1 - 1e-14 54.5 0.0 3e-09 36.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain fn3 PF00041.19 NM_019392.2_1 - 1e-13 51.3 0.0 8.7e-06 25.9 0.0 2.5 2 0 0 2 2 2 2 Fibronectin type III domain ig PF00047.23 NM_019392.2_1 - 1.4e-11 44.2 0.2 2.8e-07 30.5 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_019392.2_1 - 1.1e-08 35.1 0.2 1.1e-06 28.6 0.1 3.1 2 1 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.13 NM_019392.2_1 - 0.015 15.6 0.0 0.048 14.0 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin C1-set domain DUF4229 PF14012.4 NM_019392.2_1 - 0.12 12.4 0.1 0.31 11.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) Ig_5 PF16681.3 NM_019392.2_1 - 0.16 12.2 0.2 0.43 10.9 0.2 1.7 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain KRAB PF01352.25 NM_001001737.2_2 - 6.1e-20 70.5 0.2 1e-19 69.8 0.2 1.4 1 0 0 1 1 1 1 KRAB box SLY PF12485.6 NM_001313749.1_1 - 2.3e-46 158.2 4.5 3.8e-46 157.5 4.5 1.3 1 0 0 1 1 1 1 Lymphocyte signaling adaptor protein SAM_1 PF00536.28 NM_001313749.1_1 - 5e-08 33.1 0.1 9.4e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001313749.1_1 - 5.4e-08 32.7 0.2 8.6e-08 32.1 0.2 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.15 NM_001313749.1_1 - 3.2e-06 26.6 0.0 5.8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001313749.1_1 - 0.026 14.0 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 SH3 domain SH3_9 PF14604.4 NM_001313749.1_1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain 7tm_4 PF13853.4 NM_147115.1_1 - 1.4e-129 431.6 25.5 1.7e-129 431.3 25.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147115.1_1 - 4.8e-21 75.1 18.1 8.5e-21 74.2 18.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147115.1_1 - 9e-07 28.4 15.0 1.5e-06 27.7 15.0 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Dus PF01207.15 NM_028002.2_2 - 2.6e-72 243.4 0.1 3.4e-72 243.0 0.1 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.19 NM_028002.2_2 - 0.0011 18.3 0.0 0.0018 17.6 0.0 1.3 1 0 0 1 1 1 1 Histidine biosynthesis protein TMP-TENI PF02581.15 NM_028002.2_2 - 0.017 14.4 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Thiamine monophosphate synthase/TENI ThiG PF05690.12 NM_028002.2_2 - 0.03 13.5 0.0 0.045 12.9 0.0 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG zf-H2C2_2 PF13465.4 NM_001033159.2_2 - 9.3e-27 92.1 52.1 3.4e-07 30.3 0.9 8.7 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001033159.2_2 - 6.8e-24 82.8 52.8 7.7e-05 22.8 0.5 8.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001033159.2_2 - 2e-14 52.9 50.5 0.0056 17.3 1.1 8.3 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001033159.2_2 - 7.1e-12 44.8 41.5 0.0046 16.7 3.0 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger KRAB PF01352.25 NM_001033159.2_2 - 2.8e-11 42.7 0.0 5.4e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001033159.2_2 - 0.0012 18.9 34.5 0.39 10.9 1.2 6.4 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001033159.2_2 - 0.0023 18.1 41.7 0.0063 16.7 3.2 6.9 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 NM_001033159.2_2 - 0.65 10.6 22.8 0.16 12.6 1.5 4.1 3 1 0 3 3 3 0 zinc-ribbon family 7tm_4 PF13853.4 NM_146502.2_1 - 1.9e-44 152.4 21.5 2.4e-44 152.0 21.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146502.2_1 - 1.5e-27 96.4 20.8 3.1e-27 95.4 20.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146502.2_1 - 3.5e-05 23.2 17.6 5.6e-05 22.5 17.6 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx cNMP_binding PF00027.27 NM_011158.3_3 - 7.1e-36 122.0 0.1 8.5e-18 64.0 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 NM_011158.3_3 - 1.9e-16 59.3 0.7 3.5e-16 58.4 0.7 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit BBIP10 PF14777.4 NM_001195348.1_2 - 1.2e-30 104.8 6.8 1.8e-30 104.1 6.8 1.3 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 DUF4616 PF15394.4 NM_028890.2_3 - 3.3e-259 861.1 0.0 3.9e-259 860.9 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4616) Homeobox_KN PF05920.9 NM_010573.2_2 - 1.1e-15 57.1 0.4 2e-15 56.3 0.4 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 NM_010573.2_2 - 1e-06 28.3 0.4 2e-06 27.4 0.4 1.4 1 0 0 1 1 1 1 Homeobox domain MRP-S32 PF10210.7 NM_010573.2_2 - 0.14 12.6 0.3 0.28 11.7 0.3 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 PAF-AH_p_II PF03403.11 NM_133880.3_1 - 6.4e-153 508.6 0.0 7.7e-153 508.3 0.0 1.1 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.5 NM_133880.3_1 - 6e-06 25.2 0.0 1.5e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.19 NM_133880.3_1 - 9.4e-06 25.1 0.1 2.5e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.6 NM_133880.3_1 - 5.2e-05 22.5 0.1 0.27 10.3 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase PF07224.9 NM_133880.3_1 - 0.00017 20.6 0.1 0.3 9.9 0.0 2.2 2 0 0 2 2 2 2 Chlorophyllase DLH PF01738.16 NM_133880.3_1 - 0.00017 21.0 0.0 0.00038 20.0 0.0 1.4 1 1 0 1 1 1 1 Dienelactone hydrolase family Esterase PF00756.18 NM_133880.3_1 - 0.003 17.1 0.0 0.034 13.7 0.0 2.0 2 0 0 2 2 2 1 Putative esterase Abhydrolase_6 PF12697.5 NM_133880.3_1 - 0.003 18.1 0.0 0.013 16.1 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 NM_133880.3_1 - 0.013 15.2 0.0 0.079 12.6 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.23 NM_133880.3_1 - 0.019 14.7 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_3 PF07859.11 NM_133880.3_1 - 0.06 13.1 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.10 NM_133880.3_1 - 0.084 11.4 0.0 1 7.8 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Abhydrolase_5 PF12695.5 NM_133880.3_1 - 0.15 11.7 0.0 0.5 10.0 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family Chordopox_A30L PF06015.10 NM_001289809.1_2 - 0.048 13.4 0.2 0.19 11.4 0.2 2.1 1 0 0 1 1 1 0 Chordopoxvirus A30L protein DUF3560 PF12083.6 NM_001289809.1_2 - 1.3 9.0 12.2 0.58 10.2 5.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3560) PRANC PF09372.8 NM_001289809.1_2 - 4.3 7.6 7.7 3.6 7.8 2.1 2.7 2 1 0 2 2 2 0 PRANC domain ADK PF00406.20 NM_025647.3_3 - 1.4e-43 148.5 0.0 1.8e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.4 NM_025647.3_3 - 1.7e-37 128.7 0.0 2.3e-37 128.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 NM_025647.3_3 - 2.4e-07 31.2 0.0 3.4e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.15 NM_025647.3_3 - 1.8e-06 27.6 0.2 6.8e-05 22.5 0.2 2.1 1 1 0 1 1 1 1 Thymidylate kinase Zeta_toxin PF06414.10 NM_025647.3_3 - 0.00037 19.7 0.0 0.00052 19.2 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.4 NM_025647.3_3 - 0.00075 19.5 0.0 0.0014 18.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain PROL5-SMR PF15621.4 NM_021289.2_1 - 1.4e-32 112.1 7.8 2.5e-32 111.3 7.8 1.5 1 0 0 1 1 1 1 Proline-rich submaxillary gland androgen-regulated family Forkhead PF00250.16 NM_010446.3_1 - 5.4e-37 125.8 0.2 8.5e-37 125.2 0.2 1.3 1 0 0 1 1 1 1 Forkhead domain HNF_C PF09354.8 NM_010446.3_1 - 1.6e-24 86.5 7.6 1.6e-24 86.5 7.6 4.1 3 1 0 3 3 3 1 HNF3 C-terminal domain Forkhead_N PF08430.10 NM_010446.3_1 - 5.8e-23 81.9 39.3 5.8e-23 81.9 39.3 3.1 2 1 0 3 3 3 1 Forkhead N-terminal region THEG PF14912.4 NM_027970.1_1 - 2.3e-50 168.7 22.7 3e-18 65.9 2.5 6.0 4 1 0 5 5 5 5 Testicular haploid expressed repeat DDHD PF02862.15 NM_027970.1_1 - 0.077 13.0 11.7 0.017 15.1 5.5 2.2 2 0 0 2 2 2 0 DDHD domain Connexin PF00029.17 NM_027970.1_1 - 3.7 7.1 18.3 7.3 6.2 18.3 1.4 1 0 0 1 1 1 0 Connexin Afi1 PF07792.10 NM_027970.1_1 - 6.5 7.1 15.1 0.38 11.1 9.1 2.0 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RNA_pol_Rpc4 PF05132.12 NM_027970.1_2 - 0.03 14.6 16.3 0.048 14.0 16.3 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DDHD PF02862.15 NM_027970.1_2 - 4.2 7.3 10.9 6.1 6.8 10.9 1.2 1 0 0 1 1 1 0 DDHD domain EOS1 PF12326.6 NM_027970.1_2 - 6.1 6.6 9.6 9.8 5.9 9.6 1.3 1 0 0 1 1 1 0 N-glycosylation protein 7tm_1 PF00001.19 NM_027970.1_3 - 0.11 11.6 1.2 0.12 11.4 1.2 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) EOS1 PF12326.6 NM_027970.1_3 - 3.6 7.3 7.3 5.4 6.8 7.3 1.3 1 0 0 1 1 1 0 N-glycosylation protein DUF1443 PF07280.9 NM_138312.1_1 - 1.6 8.5 4.5 3.9 7.2 4.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1443) Arb2 PF09757.7 NM_138312.1_3 - 7.3e-09 35.3 0.3 9e-06 25.2 0.1 2.2 2 0 0 2 2 2 2 Arb2 domain Hydrolase_4 PF12146.6 NM_138312.1_3 - 0.032 13.3 0.0 0.058 12.5 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 7tm_4 PF13853.4 NM_146866.1_1 - 5.5e-46 157.4 24.1 6.4e-46 157.2 24.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146866.1_1 - 3.2e-14 52.7 24.8 7.4e-14 51.5 24.8 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146866.1_1 - 0.014 14.7 27.5 0.067 12.4 27.5 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Pkinase_Tyr PF07714.15 NM_010612.2_3 - 5.8e-101 337.0 0.0 8e-101 336.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 NM_010612.2_3 - 3.9e-59 197.1 12.1 9.8e-16 58.0 0.2 6.6 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 NM_010612.2_3 - 8.6e-51 169.8 1.8 5.5e-16 58.3 0.0 6.6 6 1 0 6 6 6 6 Immunoglobulin I-set domain Pkinase PF00069.23 NM_010612.2_3 - 9.8e-42 143.0 0.7 3.1e-30 105.3 0.0 2.5 3 0 0 3 3 3 2 Protein kinase domain Ig_2 PF13895.4 NM_010612.2_3 - 2.2e-38 130.3 18.8 2e-12 47.1 0.1 9.0 7 2 0 7 7 7 5 Immunoglobulin domain ig PF00047.23 NM_010612.2_3 - 1.1e-30 105.5 13.6 1.5e-10 40.9 0.2 6.6 7 0 0 7 7 7 5 Immunoglobulin domain V-set PF07686.15 NM_010612.2_3 - 1.1e-17 64.1 13.7 0.00019 21.4 0.0 8.7 6 2 2 8 8 8 4 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_010612.2_3 - 2e-09 37.2 4.5 0.0055 16.6 0.1 5.0 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 NM_010612.2_3 - 8.9e-08 31.9 3.8 13 5.7 0.0 6.6 6 1 0 6 6 6 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 NM_010612.2_3 - 4.9e-06 26.7 5.8 0.44 10.9 0.3 6.4 7 1 0 7 7 6 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 NM_010612.2_3 - 4.1e-05 23.7 6.1 1.1 9.5 0.0 5.8 5 1 1 6 6 6 1 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR1 PF02440.13 NM_010612.2_3 - 0.34 10.6 9.2 33 4.2 0.1 5.1 5 0 0 5 5 5 0 Adenovirus E3 region protein CR1 TSP_1 PF00090.17 NM_008823.4_3 - 2.7e-66 219.5 90.5 1.7e-17 63.2 15.2 6.8 6 1 0 6 6 6 6 Thrombospondin type 1 domain 7tm_4 PF13853.4 NM_213721.2_1 - 5.9e-57 193.4 12.3 7.2e-57 193.1 12.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_213721.2_1 - 4.2e-25 88.3 16.5 4.1e-24 85.1 16.5 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_213721.2_1 - 2.2e-05 23.8 15.2 4.7e-05 22.8 15.2 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 NM_213721.2_1 - 0.00015 21.1 2.4 0.00015 21.1 2.4 2.6 3 2 1 4 4 4 1 Serpentine type 7TM GPCR chemoreceptor Srv Lectin_C PF00059.19 NM_001253747.1_2 - 1.7e-25 89.7 0.7 5.5e-25 88.1 0.7 1.9 1 0 0 1 1 1 1 Lectin C-type domain Ly49 PF08391.8 NM_001253747.1_2 - 0.015 15.5 2.3 0.015 15.5 2.3 2.5 2 1 1 3 3 2 0 Ly49-like protein, N-terminal region Macoilin PF09726.7 NM_001253747.1_2 - 0.053 11.9 17.2 0.08 11.4 17.2 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF1664 PF07889.10 NM_001253747.1_2 - 0.064 13.1 9.3 0.12 12.2 9.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) UL45 PF05473.10 NM_001253747.1_2 - 0.096 12.2 0.1 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like ATG16 PF08614.9 NM_001253747.1_2 - 0.17 11.9 20.2 0.34 10.9 20.2 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DegS PF05384.9 NM_001253747.1_2 - 0.18 11.2 9.5 0.29 10.5 9.5 1.3 1 0 0 1 1 1 0 Sensor protein DegS Golgin_A5 PF09787.7 NM_001253747.1_2 - 0.19 11.0 16.7 0.33 10.2 16.7 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 Reo_sigmaC PF04582.10 NM_001253747.1_2 - 0.19 10.9 6.1 0.3 10.3 6.1 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Dynactin_p22 PF07426.9 NM_001253747.1_2 - 0.22 11.2 12.8 0.095 12.4 4.9 2.3 1 1 1 2 2 2 0 Dynactin subunit p22 Laminin_II PF06009.10 NM_001253747.1_2 - 0.27 11.1 14.1 0.39 10.6 13.4 1.5 1 1 0 1 1 1 0 Laminin Domain II APG6 PF04111.10 NM_001253747.1_2 - 0.33 10.2 15.5 0.49 9.6 15.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 HemX PF04375.12 NM_001253747.1_2 - 0.35 10.0 16.5 0.63 9.2 16.5 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase AAA_23 PF13476.4 NM_001253747.1_2 - 0.55 10.6 14.1 0.83 10.0 14.1 1.2 1 0 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.13 NM_001253747.1_2 - 0.63 9.4 10.6 0.9 8.9 10.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CtIP_N PF10482.7 NM_001253747.1_2 - 0.66 9.9 13.9 1.3 9.0 13.9 1.4 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Prominin PF05478.9 NM_001253747.1_2 - 1.2 6.9 11.4 1.6 6.4 11.4 1.1 1 0 0 1 1 1 0 Prominin ADIP PF11559.6 NM_001253747.1_2 - 1.9 8.4 20.2 4.3 7.3 20.2 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding IncA PF04156.12 NM_001253747.1_2 - 4.1 7.0 21.0 15 5.2 20.9 1.9 1 1 0 1 1 1 0 IncA protein Spc7 PF08317.9 NM_001253747.1_2 - 5.4 5.7 18.2 9 4.9 18.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF972 PF06156.11 NM_001253747.1_2 - 8.8 6.9 12.5 4.9 7.7 10.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF972) SH3_2 PF07653.15 NM_007764.5_2 - 1.3e-22 79.1 0.1 2.4e-11 43.0 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.22 NM_007764.5_2 - 9.2e-21 73.6 0.0 1.5e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 NM_007764.5_2 - 2e-19 68.8 0.3 4.6e-15 54.8 0.1 2.7 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 NM_007764.5_2 - 2.4e-15 55.9 0.1 2.6e-08 33.4 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain hSH3 PF14603.4 NM_007764.5_2 - 0.094 13.1 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain TFIIA_gamma_N PF02268.14 NM_001282084.1_3 - 2.4e-23 81.8 0.4 3.9e-23 81.1 0.4 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain Forkhead PF00250.16 NM_022378.3_1 - 7.3e-35 119.0 0.0 1.2e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain CTP_synth_N PF06418.12 NM_016748.2_1 - 3.5e-133 442.7 0.1 4.5e-133 442.4 0.1 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.26 NM_016748.2_1 - 9.8e-53 178.6 0.0 1.6e-52 177.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.11 NM_016748.2_1 - 1.4e-08 34.7 0.0 2.4e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 CbiA PF01656.21 NM_016748.2_1 - 0.04 13.9 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Transket_pyr PF02779.22 NM_016748.2_1 - 0.073 12.6 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain FAM177 PF14774.4 NM_001100116.1_1 - 2.4e-44 150.3 0.1 4e-44 149.6 0.1 1.3 1 0 0 1 1 1 1 FAM177 family TNF PF00229.16 NM_009425.2_2 - 4.9e-44 149.2 1.0 7.7e-44 148.6 1.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family EB1 PF03271.15 NM_001162941.1_2 - 2.7e-15 56.2 0.9 5.3e-15 55.2 0.9 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.29 NM_001162941.1_2 - 3.6e-11 43.1 0.2 6.2e-11 42.3 0.2 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_001162941.1_2 - 0.013 15.2 0.1 0.029 14.1 0.1 1.5 1 0 0 1 1 1 0 CAMSAP CH domain ING PF12998.5 NM_001162941.1_2 - 0.052 14.0 1.0 0.099 13.1 1.0 1.4 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding IL11 PF07400.9 NM_008350.4_3 - 1.3e-100 334.6 16.3 1.9e-100 334.0 16.3 1.2 1 0 0 1 1 1 1 Interleukin 11 DUF4560 PF15118.4 NM_001271583.1_2 - 1.1e-34 118.1 0.3 1.9e-34 117.4 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4560) CAF1 PF04857.18 NM_001271542.1_3 - 8.8e-21 74.3 0.2 1.8e-10 40.4 0.1 2.4 1 1 0 2 2 2 2 CAF1 family ribonuclease DUF4078 PF13300.4 NM_172730.2_3 - 9.8e-28 96.2 12.0 9.8e-28 96.2 12.0 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) DUF4516 PF14990.4 NM_001135567.1_1 - 7e-25 86.4 1.6 1.5e-24 85.3 1.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4516) Glyco_hydro_35 PF01301.17 NM_029010.1_3 - 1.9e-120 402.1 0.0 2.4e-120 401.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.13 NM_029010.1_3 - 2.2e-10 40.3 0.1 2.9e-09 36.6 0.1 2.0 1 1 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.4 NM_029010.1_3 - 0.025 15.0 0.1 0.071 13.5 0.1 1.7 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain Pyr_redox_2 PF07992.12 NM_021507.5_1 - 1.3e-15 57.3 0.0 2.5e-08 33.4 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.10 NM_021507.5_1 - 0.037 12.9 0.1 0.13 11.2 0.1 1.8 1 1 1 2 2 2 0 Lycopene cyclase protein Spermine_synth PF01564.15 NM_021507.5_1 - 0.15 10.8 0.1 0.25 10.2 0.1 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase Pyr_redox_3 PF13738.4 NM_021507.5_1 - 0.16 11.0 0.2 2 7.5 0.1 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase WD40 PF00400.30 NM_001111279.1_1 - 3.4e-18 65.5 8.4 0.00015 22.4 0.6 6.1 5 0 0 5 5 5 5 WD domain, G-beta repeat FYVE PF01363.19 NM_001111279.1_1 - 6.2e-14 51.7 7.4 1.8e-13 50.3 7.4 1.8 1 0 0 1 1 1 1 FYVE zinc finger ANAPC4_WD40 PF12894.5 NM_001111279.1_1 - 0.0021 18.2 0.1 1.2 9.3 0.0 2.7 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Patched PF02460.16 NM_001312903.1_2 - 1.9e-70 237.8 3.2 5.1e-38 130.6 0.0 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.6 NM_001312903.1_2 - 8.6e-47 158.7 2.0 8.6e-47 158.7 2.0 2.4 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.13 NM_001312903.1_2 - 0.026 13.3 18.8 0.38 9.5 3.2 2.2 2 0 0 2 2 2 0 MMPL family Josephin PF02099.15 NM_001205071.1_1 - 1e-25 90.5 0.0 2.5e-24 86.1 0.0 2.0 1 1 0 1 1 1 1 Josephin DAGK_cat PF00781.22 NM_203280.3_2 - 4.1e-27 94.1 0.0 5.9e-27 93.6 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain V1R PF03402.12 NM_145844.1_1 - 2.3e-33 115.8 5.6 3.4e-33 115.3 5.6 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_145844.1_1 - 0.00021 20.4 16.2 0.00066 18.8 16.2 1.7 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_145844.1_1 - 0.013 14.7 3.2 0.032 13.3 3.2 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Lectin_C PF00059.19 NM_001290660.1_2 - 2.2e-10 41.1 0.4 3.4e-10 40.5 0.4 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 NM_001290660.1_2 - 0.0016 18.0 0.0 0.0038 16.8 0.0 1.6 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Cupin_8 PF13621.4 NM_001302962.1_1 - 1.8e-40 139.2 0.0 2.5e-40 138.8 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.10 NM_001302962.1_1 - 1.8e-08 34.1 0.0 4.8e-08 32.7 0.0 1.7 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.20 NM_001302962.1_1 - 0.02 15.2 0.0 0.04 14.3 0.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase Pou PF00157.15 NM_011138.2_3 - 8.9e-38 128.0 0.2 1.7e-37 127.1 0.2 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 NM_011138.2_3 - 1.8e-16 59.6 3.7 3.9e-16 58.5 3.7 1.6 1 0 0 1 1 1 1 Homeobox domain Peptidase_S9 PF00326.19 NM_145984.3_2 - 9.2e-33 113.4 0.0 1.4e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.13 NM_145984.3_2 - 8.2e-27 93.9 0.4 1.3e-26 93.3 0.4 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain B-block_TFIIIC PF04182.10 NM_207239.1_3 - 9e-21 73.7 0.2 4.6e-20 71.4 0.0 2.4 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC HAGH_C PF16123.3 NM_001271435.1_3 - 6.1e-18 65.0 0.0 1e-17 64.3 0.0 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 NM_001271435.1_3 - 7.9e-08 32.4 4.7 1.9e-06 27.9 4.7 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 NM_001271435.1_3 - 0.0098 15.3 0.2 0.022 14.2 0.2 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Nuc_deoxyrib_tr PF05014.13 NM_207161.3_1 - 2.9e-18 66.0 0.0 3.9e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase HATPase_c_3 PF13589.4 NM_177719.4_3 - 1.5e-29 102.5 0.0 3e-29 101.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-CW PF07496.13 NM_177719.4_3 - 9.1e-14 51.1 0.7 2.5e-13 49.7 0.7 1.8 1 0 0 1 1 1 1 CW-type Zinc Finger HATPase_c PF02518.24 NM_177719.4_3 - 0.00059 20.3 0.1 0.0027 18.1 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Snapin_Pallidin PF14712.4 NM_177719.4_3 - 2.5 8.5 11.3 3.7 7.9 3.2 2.7 2 0 0 2 2 2 0 Snapin/Pallidin HlyIII PF03006.18 NM_001310597.1_1 - 5.1e-20 72.0 10.0 1.8e-17 63.7 0.4 2.6 2 1 1 3 3 3 2 Haemolysin-III related OppC_N PF12911.5 NM_001310597.1_1 - 0.12 12.3 1.0 11 6.0 0.0 2.5 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Cu_amine_oxid PF01179.18 NM_001029987.1_1 - 1.2e-88 297.6 2.2 1.6e-88 297.2 2.2 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.14 NM_001029987.1_1 - 9.7e-24 83.3 0.0 1.8e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.14 NM_001029987.1_1 - 1e-13 51.4 0.0 2.3e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain DUF1965 PF09248.8 NM_001029987.1_1 - 3.8e-05 23.3 0.0 9.2e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) RGS PF00615.17 NM_134257.3_3 - 6.4e-36 123.1 3.4 1.1e-35 122.4 3.4 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain PDZ PF00595.22 NM_134257.3_3 - 7.9e-07 29.2 0.0 1.5e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_134257.3_3 - 0.00015 21.9 0.0 0.0003 20.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Y_phosphatase PF00102.25 NM_001161838.1_2 - 4.8e-74 248.7 0.1 6.6e-74 248.3 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 NM_001161838.1_2 - 0.00049 19.8 0.0 0.001 18.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_001161838.1_2 - 0.00099 19.0 0.0 0.0023 17.8 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Trypsin PF00089.24 NM_001302499.1_2 - 7.7e-41 140.2 0.0 9.6e-41 139.9 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_001302499.1_2 - 0.00065 20.5 0.0 0.00098 19.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S29 PF02907.13 NM_001302499.1_2 - 0.019 14.6 0.1 0.03 13.9 0.1 1.3 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease 7tm_4 PF13853.4 NM_147106.2_2 - 5.5e-55 186.9 17.2 6.8e-55 186.6 17.2 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147106.2_2 - 1.3e-22 80.2 20.9 2.7e-22 79.2 20.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147106.2_2 - 0.036 13.3 18.2 0.17 11.1 18.2 2.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx RRM_1 PF00076.20 NM_011251.3_2 - 0.00016 21.3 0.0 0.007 16.0 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pentapeptide_4 PF13599.4 NM_011251.3_2 - 0.00036 20.5 0.1 0.018 15.1 0.0 2.5 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) G-patch PF01585.21 NM_011251.3_2 - 0.0017 18.1 4.8 0.0039 17.0 4.8 1.6 1 0 0 1 1 1 1 G-patch domain zf-C2H2_jaz PF12171.6 NM_011251.3_2 - 0.088 13.0 0.1 0.23 11.7 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding ArfGap PF01412.16 NM_001276463.1_2 - 8.5e-35 119.2 0.0 1.7e-34 118.2 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.3 NM_001276463.1_2 - 1.8e-26 93.2 12.6 2.9e-26 92.5 12.6 1.3 1 0 0 1 1 1 1 BAR domain of APPL family Ank_2 PF12796.5 NM_001276463.1_2 - 4.4e-17 62.3 0.6 6e-09 36.2 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PH PF00169.27 NM_001276463.1_2 - 7.5e-10 39.1 0.3 1.8e-09 37.9 0.3 1.7 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.26 NM_001276463.1_2 - 3.1e-09 36.2 0.3 6.3e-09 35.2 0.3 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001276463.1_2 - 5.1e-09 35.7 0.1 9.4e-09 34.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.28 NM_001276463.1_2 - 9.7e-09 35.2 0.1 0.00045 20.4 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat BAR PF03114.16 NM_001276463.1_2 - 1.4e-08 34.6 7.1 2.3e-08 33.9 7.1 1.3 1 0 0 1 1 1 1 BAR domain SH3_2 PF07653.15 NM_001276463.1_2 - 7.4e-07 28.6 0.2 1.5e-06 27.7 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_4 PF13637.4 NM_001276463.1_2 - 3.2e-06 27.4 0.0 0.00042 20.7 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001276463.1_2 - 3.8e-05 23.6 0.0 0.12 12.8 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 NM_001276463.1_2 - 0.0027 17.9 0.5 0.037 14.3 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeats (many copies) DUF4404 PF14357.4 NM_001276463.1_2 - 0.087 13.4 5.3 0.35 11.4 2.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Fib_alpha PF08702.8 NM_001276463.1_2 - 3.3 7.8 7.4 23 5.0 2.3 2.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FXa_inhibition PF14670.4 NM_207109.2_1 - 5.6e-10 39.2 4.3 5.6e-10 39.2 4.3 4.0 4 0 0 4 4 4 2 Coagulation Factor Xa inhibitory site MACPF PF01823.17 NM_207109.2_1 - 2.3e-08 34.3 1.5 4.5e-07 30.1 0.3 2.4 2 0 0 2 2 2 1 MAC/Perforin domain cEGF PF12662.5 NM_207109.2_1 - 0.0062 16.3 5.1 0.17 11.7 0.4 3.1 2 0 0 2 2 2 2 Complement Clr-like EGF-like Herpes_gE PF02480.14 NM_207109.2_1 - 0.015 14.0 0.0 0.025 13.2 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E P53 PF00870.16 NM_001126330.1_2 - 6.2e-112 371.8 0.2 1.1e-111 371.0 0.2 1.4 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 NM_001126330.1_2 - 1.7e-17 62.3 0.4 3.2e-17 61.4 0.4 1.4 1 0 0 1 1 1 1 P53 tetramerisation motif SAM_2 PF07647.15 NM_001126330.1_2 - 6.2e-08 32.5 0.0 1e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_001126330.1_2 - 0.0049 17.1 0.0 0.0087 16.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Nucleoside_tran PF01733.16 NM_001199116.1_2 - 7.1e-127 422.9 2.5 7.1e-127 422.9 2.5 2.2 1 1 2 3 3 3 1 Nucleoside transporter RRM_1 PF00076.20 NM_001164079.1_3 - 3.9e-56 186.6 0.0 1.1e-22 79.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001164079.1_3 - 5.8e-06 26.2 0.1 1.3 9.1 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif RRM_occluded PF16842.3 NM_001164079.1_3 - 0.0025 17.5 0.0 0.02 14.6 0.0 2.3 3 0 0 3 3 3 1 Occluded RNA-recognition motif Ig_3 PF13927.4 NM_013489.3_3 - 6.5e-08 32.9 1.7 0.00034 21.0 2.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_013489.3_3 - 3.2e-06 27.1 2.7 0.29 11.2 1.8 3.4 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_013489.3_3 - 3.7e-06 26.9 0.3 0.00088 19.3 0.0 2.4 1 1 1 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.14 NM_013489.3_3 - 6.8e-05 22.7 0.4 0.08 12.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_013489.3_3 - 0.00016 21.8 3.9 0.0014 18.8 3.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ets PF00178.20 NM_001291062.1_1 - 5.7e-34 116.3 1.2 1e-33 115.5 1.2 1.4 1 0 0 1 1 1 1 Ets-domain Elf-1_N PF12310.6 NM_001291062.1_1 - 8.6e-06 26.1 0.1 2e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 Transcription factor protein N terminal CTP_transf_1 PF01148.18 NM_001291040.1_3 - 2.6e-09 37.1 4.8 3.5e-09 36.7 4.8 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family CBF_beta PF02312.15 NM_022309.4_3 - 1.2e-83 278.6 3.5 1.6e-83 278.2 3.5 1.1 1 0 0 1 1 1 1 Core binding factor beta subunit RmlD_sub_bind PF04321.15 NM_001199274.1_3 - 7.7e-87 290.9 0.0 9.3e-87 290.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.19 NM_001199274.1_3 - 1.8e-22 79.9 0.0 2.6e-22 79.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 NM_001199274.1_3 - 8.9e-09 35.0 0.1 1.6e-08 34.2 0.1 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 NM_001199274.1_3 - 8.7e-08 31.5 0.1 1.9e-05 23.8 0.0 2.6 1 1 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.10 NM_001199274.1_3 - 0.00083 18.5 0.1 0.079 12.0 0.0 2.5 1 1 1 2 2 2 1 Male sterility protein DapB_N PF01113.18 NM_001199274.1_3 - 0.13 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus UBA_5 PF16577.3 NM_011018.3_1 - 1.2e-43 146.9 0.2 2.2e-43 146.1 0.2 1.4 1 0 0 1 1 1 1 UBA domain PB1 PF00564.22 NM_011018.3_1 - 4.8e-12 45.5 0.0 9.4e-12 44.6 0.0 1.5 1 0 0 1 1 1 1 PB1 domain ZZ PF00569.15 NM_011018.3_1 - 1.1e-11 44.2 4.0 2.3e-11 43.2 4.0 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.14 NM_011018.3_1 - 0.0015 18.6 3.6 0.0039 17.4 3.6 1.7 1 0 0 1 1 1 1 C1 domain PSP PF04046.14 NM_011018.3_2 - 0.043 13.6 0.2 0.088 12.6 0.2 1.5 1 0 0 1 1 1 0 PSP Thyroglobulin_1 PF00086.16 NM_008341.4_2 - 2.3e-23 81.5 2.7 4.1e-23 80.7 2.7 1.4 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 NM_008341.4_2 - 1.6e-08 34.9 21.0 7.5e-08 32.8 21.0 2.3 1 0 0 1 1 1 1 Insulin-like growth factor binding protein DUF1566 PF07603.9 NM_008341.4_2 - 0.075 13.3 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1566) Cor1 PF04803.10 NM_001099325.2_1 - 1.4e-08 34.9 8.0 1.4e-08 34.9 8.0 1.9 2 0 0 2 2 2 1 Cor1/Xlr/Xmr conserved region HATPase_c_3 PF13589.4 NM_198162.1_1 - 0.012 15.4 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 NM_198162.1_2 - 7.8e-17 61.3 0.0 1.6e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-CW PF07496.13 NM_198162.1_2 - 4.2e-15 55.4 3.5 8.7e-15 54.4 3.5 1.6 1 0 0 1 1 1 1 CW-type Zinc Finger YscO PF07321.10 NM_028804.1_3 - 0.0017 18.2 6.8 0.0017 18.2 6.8 2.0 2 0 0 2 2 2 1 Type III secretion protein YscO IncA PF04156.12 NM_028804.1_3 - 1.8 8.2 8.0 3.6 7.2 8.0 1.4 1 0 0 1 1 1 0 IncA protein SR-25 PF10500.7 NM_028804.1_3 - 2 7.8 46.8 0.063 12.8 36.1 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SlyX PF04102.10 NM_028804.1_3 - 3.2 8.3 4.6 5 7.7 3.8 1.6 1 1 0 1 1 1 0 SlyX LIM PF00412.20 NM_001190854.1_1 - 3.2e-37 126.4 27.7 2.6e-14 53.0 2.2 3.7 3 0 0 3 3 3 3 LIM domain PDZ PF00595.22 NM_001190854.1_1 - 1.4e-12 47.7 0.0 2.4e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DUF4749 PF15936.3 NM_001190854.1_1 - 9e-07 29.9 0.4 1.7e-06 29.0 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ_2 PF13180.4 NM_001190854.1_1 - 0.019 15.1 0.0 0.035 14.3 0.0 1.3 1 0 0 1 1 1 0 PDZ domain PI3_PI4_kinase PF00454.25 NM_001293716.1_2 - 7.7e-34 117.5 0.2 2.7e-23 82.9 0.2 2.2 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.4 NM_001293716.1_2 - 0.028 13.6 0.0 0.041 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) ParcG PF10274.7 NM_025755.3_1 - 8.4e-50 169.3 0.0 1.1e-49 168.9 0.0 1.2 1 0 0 1 1 1 1 Parkin co-regulated protein HEAT_EZ PF13513.4 NM_025755.3_1 - 0.16 12.4 0.6 1.6 9.1 0.1 2.4 1 1 1 2 2 2 0 HEAT-like repeat Maf1 PF09174.8 NM_001164608.1_1 - 4.8e-63 211.9 0.0 6.4e-63 211.5 0.0 1.2 1 0 0 1 1 1 1 Maf1 regulator DUF3585 PF12130.6 NM_138315.2_2 - 1.4e-31 109.3 24.8 1.4e-31 109.3 24.8 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF3585) CH PF00307.29 NM_138315.2_2 - 1e-18 67.3 0.0 2.3e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain Pyr_redox_2 PF07992.12 NM_138315.2_2 - 3.7e-07 29.6 1.4 0.00059 19.0 0.1 1.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.17 NM_138315.2_2 - 3e-06 26.6 0.0 5.4e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.22 NM_138315.2_2 - 0.00018 20.6 1.3 0.00019 20.5 0.2 1.6 2 0 0 2 2 2 1 FAD binding domain LIM PF00412.20 NM_138315.2_2 - 0.00021 21.3 10.2 0.00021 21.3 10.2 1.8 2 0 0 2 2 1 1 LIM domain DAO PF01266.22 NM_138315.2_2 - 0.00026 20.6 0.6 0.057 12.9 0.6 3.3 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.4 NM_138315.2_2 - 0.00094 18.4 0.0 0.0018 17.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 NM_138315.2_2 - 0.0016 17.1 0.1 0.0028 16.3 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein CAMSAP_CH PF11971.6 NM_138315.2_2 - 0.0021 17.7 0.0 0.0049 16.5 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain FAD_oxidored PF12831.5 NM_138315.2_2 - 0.0037 16.5 0.5 0.0083 15.4 0.5 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.4 NM_138315.2_2 - 0.0045 17.3 0.0 0.0099 16.2 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_8 PF13450.4 NM_138315.2_2 - 0.0045 17.1 0.2 0.0097 16.0 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.20 NM_138315.2_2 - 0.0046 16.0 0.0 0.0078 15.2 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.25 NM_138315.2_2 - 0.011 16.2 0.1 0.032 14.7 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.15 NM_138315.2_2 - 0.012 14.8 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Glyco_transf_10 PF00852.17 NM_138315.2_2 - 0.049 13.2 0.1 0.1 12.2 0.1 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 10 (fucosyltransferase) C-term AlaDh_PNT_C PF01262.19 NM_138315.2_2 - 0.052 12.7 0.0 0.095 11.8 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.19 NM_138315.2_2 - 0.097 11.9 0.1 0.2 10.8 0.1 1.4 1 0 0 1 1 1 0 ThiF family Lycopene_cycl PF05834.10 NM_138315.2_2 - 0.13 11.1 0.0 0.23 10.3 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein DUF4778 PF16008.3 NM_138315.2_2 - 0.17 11.8 4.2 0.29 11.0 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Radial_spoke PF04712.10 NM_138315.2_2 - 1.7 7.4 12.0 0.014 14.3 3.9 1.5 2 0 0 2 2 1 0 Radial spokehead-like protein HSP70 PF00012.18 NM_028306.3_1 - 0.00082 17.5 0.3 0.12 10.4 0.0 2.6 2 1 0 2 2 2 2 Hsp70 protein Peptidase_M49 PF03571.13 NM_133803.2_2 - 7.6e-233 773.7 0.0 8.9e-233 773.5 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M49 DUF1107 PF06526.10 NM_133803.2_2 - 0.11 12.3 0.0 7.2 6.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1107) IRF-3 PF10401.7 NM_001301811.1_2 - 4.6e-64 215.4 0.2 6.6e-64 214.9 0.2 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 NM_001301811.1_2 - 9.3e-42 141.4 0.6 1.5e-41 140.8 0.6 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor MH2 PF03166.12 NM_001301811.1_2 - 0.00042 20.4 0.0 0.00069 19.7 0.0 1.2 1 0 0 1 1 1 1 MH2 domain Ig_3 PF13927.4 NM_198610.2_3 - 7.6e-16 58.4 0.0 1.6e-05 25.3 0.0 3.9 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_198610.2_3 - 5.9e-10 39.2 0.0 0.043 14.0 0.0 4.8 5 1 0 5 5 5 3 Immunoglobulin domain I-set PF07679.14 NM_198610.2_3 - 1.6e-08 34.3 0.0 0.0033 17.3 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.15 NM_198610.2_3 - 2e-07 31.0 0.0 1.7e-06 28.0 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_198610.2_3 - 2.4e-06 27.4 0.0 0.049 13.6 0.0 3.2 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain ig PF00047.23 NM_198610.2_3 - 3.6e-06 26.9 0.0 0.8 9.8 0.0 3.7 4 0 0 4 4 4 2 Immunoglobulin domain PGAP1 PF07819.11 NM_001111017.1_3 - 0.034 13.7 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Hydrolase_4 PF12146.6 NM_001111017.1_3 - 0.086 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Gaa1 PF04114.12 NM_010331.2_1 - 6.7e-152 506.7 1.0 9.6e-152 506.2 1.0 1.2 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component DUF4530 PF15039.4 NM_010331.2_1 - 0.042 13.9 0.3 0.094 12.7 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) 7tm_1 PF00001.19 NM_001271716.1_3 - 1.3e-29 103.2 29.1 6.3e-28 97.6 29.1 2.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001271716.1_3 - 1.3e-12 47.5 20.4 5.5e-11 42.2 20.4 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001271716.1_3 - 2.2e-06 27.1 14.9 2.2e-06 27.1 14.9 2.3 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 NM_001271716.1_3 - 1.2e-05 25.1 18.3 4.5e-05 23.2 12.7 2.4 1 1 1 2 2 2 2 Olfactory receptor Ets PF00178.20 NM_008065.2_3 - 6.1e-33 113.0 0.3 1.1e-32 112.2 0.3 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 NM_008065.2_3 - 5.6e-29 99.8 0.2 1.1e-28 98.9 0.2 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain GABP-alpha PF11620.6 NM_008065.2_3 - 9.3e-29 99.3 0.6 1.8e-28 98.4 0.6 1.5 1 0 0 1 1 1 1 GA-binding protein alpha chain 5_nucleotid PF05761.12 NM_001164365.1_1 - 1.1e-175 584.8 0.0 1.3e-175 584.6 0.0 1.1 1 0 0 1 1 1 1 5' nucleotidase family DUF3923 PF13061.4 NM_001164365.1_1 - 1.6 8.8 5.5 0.19 11.7 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3923) Piwi PF02171.15 NM_153177.3_1 - 1.7e-102 342.6 0.0 2.3e-102 342.1 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 NM_153177.3_1 - 2.7e-32 110.7 0.1 6.5e-32 109.5 0.1 1.7 1 0 0 1 1 1 1 Mid domain of argonaute PAZ PF02170.20 NM_153177.3_1 - 3.2e-29 101.4 1.7 4.9e-29 100.8 1.7 1.3 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.3 NM_153177.3_1 - 2e-27 96.3 0.0 3.6e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 NM_153177.3_1 - 1.5e-22 78.8 0.1 2.8e-22 77.9 0.1 1.5 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.3 NM_153177.3_1 - 6.3e-15 55.1 0.0 1.3e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain 7tm_4 PF13853.4 NM_019473.1_2 - 5.3e-58 196.8 15.0 6.6e-58 196.5 15.0 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_019473.1_2 - 7.9e-25 87.5 16.8 1.6e-24 86.4 16.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MMS1_N PF10433.7 NM_133953.2_2 - 1.1e-184 614.4 0.0 2.7e-184 613.2 0.0 1.6 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.13 NM_133953.2_2 - 7.1e-103 344.2 0.0 2.8e-101 338.9 0.0 2.4 2 0 0 2 2 2 2 CPSF A subunit region DUF4533 PF15047.4 NM_178776.3_3 - 2.8e-93 311.6 11.6 3.5e-93 311.3 11.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4533) DUF3463 PF11946.6 NM_178776.3_3 - 0.027 14.2 0.3 0.086 12.5 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3463) Ank_2 PF12796.5 NM_001277281.2_1 - 1.3e-151 493.4 35.7 4.2e-18 65.6 0.3 12.3 1 1 9 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.28 NM_001277281.2_1 - 1.6e-129 417.1 65.5 1.6e-07 31.3 0.0 22.9 22 1 1 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 NM_001277281.2_1 - 8.6e-126 408.7 33.6 6.1e-12 45.7 0.0 16.2 5 4 10 17 17 17 17 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001277281.2_1 - 2.3e-120 390.4 45.3 9.2e-12 44.8 0.0 18.4 4 3 15 20 20 20 18 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001277281.2_1 - 1.7e-117 368.8 39.0 5.2e-06 26.3 0.0 23.6 23 0 0 23 23 23 20 Ankyrin repeat ZU5 PF00791.18 NM_001277281.2_1 - 1.4e-33 114.9 0.1 1e-26 92.9 0.0 2.7 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 NM_001277281.2_1 - 1.9e-27 95.1 0.6 3.8e-27 94.2 0.6 1.5 1 0 0 1 1 1 1 Death domain DUF927 PF06048.9 NM_001277281.2_1 - 0.16 11.3 0.2 9.6 5.5 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF927) 7tm_3 PF00003.20 NM_001081448.1_1 - 2.5e-59 200.8 26.5 2.5e-59 200.8 26.5 1.9 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001081448.1_1 - 2e-34 119.1 1.0 3e-34 118.5 1.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001081448.1_1 - 5.1e-18 64.7 14.0 5.1e-18 64.7 14.0 2.0 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peptidase_M14 PF00246.22 NM_001289657.1_2 - 2.6e-17 63.4 0.0 6.2e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 Zinc carboxypeptidase C_Hendra PF16821.3 NM_001289657.1_2 - 0.1 12.4 4.6 0.25 11.1 4.6 1.6 1 0 0 1 1 1 0 C protein from hendra and measles viruses Sulfotransfer_2 PF03567.12 NM_001077202.2_1 - 1.7e-74 250.8 0.5 3.1e-74 249.9 0.1 1.7 2 0 0 2 2 2 1 Sulfotransferase family Trypan_PARP PF05887.9 NM_001077202.2_3 - 0.84 9.5 17.5 1.4 8.8 17.5 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4207 PF13904.4 NM_001081230.1_2 - 4.4e-06 26.5 81.6 6.7e-05 22.6 49.2 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF4207) Cor1 PF04803.10 NM_029181.1_1 - 2.6e-05 24.3 4.3 0.00013 22.0 2.8 2.4 1 1 1 2 2 2 1 Cor1/Xlr/Xmr conserved region zf-C4 PF00105.16 NM_013646.2_1 - 1.3e-32 112.0 12.9 4.7e-32 110.1 12.9 2.1 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_013646.2_1 - 8.7e-23 80.9 4.4 1.5e-22 80.1 4.4 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DSPc PF00782.18 NM_010146.2_3 - 1.2e-13 50.8 0.0 2.6e-13 49.8 0.0 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CBM_20 PF00686.17 NM_010146.2_3 - 9.7e-08 31.7 0.0 3.4e-07 29.9 0.0 1.9 1 1 0 1 1 1 1 Starch binding domain Y_phosphatase2 PF03162.11 NM_010146.2_3 - 0.018 14.5 0.0 0.046 13.2 0.0 1.6 2 0 0 2 2 2 0 Tyrosine phosphatase family AlaDh_PNT_N PF05222.13 NM_010146.2_3 - 0.025 14.8 0.0 0.06 13.5 0.0 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, N-terminal domain CDKN3 PF05706.10 NM_010146.2_3 - 0.12 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Feld-I_B PF09252.8 NM_001281523.1_2 - 2.8e-05 23.9 0.0 4e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Allergen Fel d I-B chain Cyclin_N PF00134.21 NM_026484.3_3 - 5e-14 52.1 0.2 7.8e-14 51.4 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.9 NM_026484.3_3 - 7.4e-11 42.5 0.1 1.2e-10 41.9 0.1 1.3 1 0 0 1 1 1 1 Cyclin V-set PF07686.15 NM_015790.3_2 - 4.5e-08 33.1 0.5 1.7e-07 31.2 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_015790.3_2 - 2.2e-07 30.7 0.4 1.1e-06 28.5 0.1 2.4 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 NM_015790.3_2 - 7.8e-06 26.3 1.6 0.062 13.8 0.1 3.0 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_015790.3_2 - 0.00027 20.9 0.5 0.007 16.4 0.1 2.8 3 0 0 3 3 3 1 Immunoglobulin domain DUF4519 PF15012.4 NM_015790.3_2 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) RINGv PF12906.5 NM_001293784.1_3 - 2.5e-15 56.2 16.4 6.9e-15 54.8 16.4 1.9 1 0 0 1 1 1 1 RING-variant domain MIP PF00230.18 NM_001308645.1_1 - 3.6e-72 242.6 18.1 5.1e-72 242.1 18.1 1.1 1 0 0 1 1 1 1 Major intrinsic protein Cation_efflux PF01545.19 NM_144798.6_2 - 9.8e-31 106.9 13.4 1.5e-30 106.3 13.4 1.3 1 0 0 1 1 1 1 Cation efflux family zf-LYAR PF08790.9 NM_144798.6_3 - 0.21 11.4 3.4 0.73 9.7 0.6 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Homeobox PF00046.27 NM_001025567.1_1 - 1.4e-21 75.9 3.6 2.8e-21 74.9 3.6 1.5 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 NM_001025567.1_1 - 3.8e-05 23.2 1.2 8e-05 22.2 1.2 1.6 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 NM_001025567.1_1 - 0.06 13.1 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain BLM_N PF16202.3 NM_007550.4_2 - 2.4e-158 526.9 29.4 2.4e-158 526.9 29.4 1.9 2 0 0 2 2 2 1 N-terminal region of Bloom syndrome protein BDHCT_assoc PF16204.3 NM_007550.4_2 - 3.2e-104 347.3 8.2 3.2e-104 347.3 8.2 2.2 2 0 0 2 2 2 1 BDHCT-box associated domain on Bloom syndrome protein BDHCT PF08072.9 NM_007550.4_2 - 7.1e-22 77.1 1.2 1.6e-21 75.9 1.2 1.7 1 0 0 1 1 1 1 BDHCT (NUC031) domain DEAD PF00270.27 NM_007550.4_2 - 9.6e-20 70.9 0.0 2e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.3 NM_007550.4_2 - 2.3e-16 60.1 3.6 2.3e-16 60.1 3.6 2.9 2 0 0 2 2 2 1 RecQ zinc-binding Helicase_C PF00271.29 NM_007550.4_2 - 1.9e-15 57.1 0.0 1.2e-14 54.4 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RQC PF09382.8 NM_007550.4_2 - 6.4e-15 54.8 0.0 1.3e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 RQC domain HRDC PF00570.21 NM_007550.4_2 - 5.9e-12 45.2 0.0 1.2e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.13 NM_007550.4_2 - 0.0022 17.9 0.0 0.0095 15.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Y_Y_Y PF07495.11 NM_133886.2_3 - 2e-12 46.7 1.6 0.016 15.0 0.0 5.3 5 0 0 5 5 5 3 Y_Y_Y domain PKD PF00801.18 NM_133886.2_3 - 3.7e-08 33.0 15.9 0.0038 16.9 1.0 5.7 5 0 0 5 5 5 2 PKD domain DUF4625 PF15418.4 NM_133886.2_3 - 9.3e-08 32.3 1.3 0.44 10.6 0.0 4.6 5 0 0 5 5 5 3 Domain of unknown function (DUF4625) He_PIG PF05345.10 NM_133886.2_3 - 1.1e-05 25.4 6.3 5 7.2 0.0 5.6 5 0 0 5 5 5 2 Putative Ig domain Big_3_2 PF12245.6 NM_133886.2_3 - 0.00034 20.2 0.4 0.76 9.5 0.1 3.3 3 0 0 3 3 3 2 Bacterial Ig-like domain (group 3) Wzt_C PF14524.4 NM_133886.2_3 - 0.00038 20.4 0.2 10 6.0 0.0 4.5 5 0 0 5 5 5 0 Wzt C-terminal domain DUF5013 PF16405.3 NM_133886.2_3 - 0.0018 18.4 4.7 1 9.5 0.1 4.7 4 1 0 5 5 5 1 Domain of unknown function (DUF5013) Cupredoxin_1 PF13473.4 NM_133886.2_3 - 0.0055 16.7 0.4 1.9 8.5 0.0 4.3 3 1 2 5 5 5 1 Cupredoxin-like domain DUF4998 PF16389.3 NM_133886.2_3 - 0.0059 16.1 1.3 4.3 6.7 0.0 3.7 4 0 0 4 4 4 1 Domain of unknown function EGF_2 PF07974.11 NM_133886.2_3 - 0.0075 16.5 4.2 0.046 14.0 4.2 2.4 1 0 0 1 1 1 1 EGF-like domain Fungus-induced PF10917.6 NM_133886.2_3 - 0.053 13.7 0.0 1.5 9.1 0.0 2.7 2 0 0 2 2 2 0 Fungus-induced protein CHU_C PF13585.4 NM_133886.2_3 - 0.055 13.4 0.7 46 4.0 0.0 4.1 5 0 0 5 5 4 0 C-terminal domain of CHU protein family BiPBP_C PF06832.10 NM_133886.2_3 - 0.063 13.2 0.1 28 4.7 0.0 3.8 3 0 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family DUF5011 PF16403.3 NM_133886.2_3 - 0.072 13.1 9.4 8.6 6.4 0.1 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) SHS2_Rpb7-N PF03876.15 NM_133886.2_3 - 0.14 12.4 0.1 0.41 10.9 0.1 1.8 1 0 0 1 1 1 0 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 AMPK1_CBM PF16561.3 NM_133886.2_3 - 0.17 12.0 0.3 4.8 7.3 0.0 3.2 4 0 0 4 4 2 0 Glycogen recognition site of AMP-activated protein kinase CopC PF04234.10 NM_133886.2_3 - 0.42 11.6 6.2 13 6.8 0.0 4.3 4 0 0 4 4 4 0 CopC domain SH3_9 PF14604.4 NM_009166.3_3 - 1.7e-37 126.9 1.1 2.3e-14 52.8 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 NM_009166.3_3 - 2.7e-36 122.8 0.2 3.7e-11 42.3 0.0 3.5 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 NM_009166.3_3 - 1.7e-29 101.2 0.2 3.7e-12 45.6 0.0 3.5 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 NM_009166.3_3 - 1.2e-22 79.1 0.7 2.3e-22 78.3 0.7 1.5 1 0 0 1 1 1 1 Sorbin homologous domain Ras PF00071.20 NM_028712.4_2 - 1.6e-54 183.7 0.0 2.2e-54 183.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_028712.4_2 - 2.9e-18 66.1 0.0 4.2e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_028712.4_2 - 1.9e-08 33.8 0.0 2.6e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 NM_028712.4_2 - 0.00041 20.2 0.2 0.12 12.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_028712.4_2 - 0.001 18.5 0.0 0.0021 17.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 NM_028712.4_2 - 0.008 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase zf-H2C2_2 PF13465.4 NM_029162.2_2 - 9.9e-41 136.3 54.7 2.4e-08 33.9 2.8 8.4 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_029162.2_2 - 4.8e-35 117.9 48.0 6.6e-06 26.2 1.1 7.7 7 0 0 7 7 7 7 Zinc finger, C2H2 type BTB PF00651.29 NM_029162.2_2 - 3.9e-26 91.3 0.7 7.3e-26 90.4 0.7 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 NM_029162.2_2 - 8.1e-23 79.0 49.8 0.001 19.6 0.9 8.3 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_029162.2_2 - 5.1e-16 58.4 19.8 0.0051 16.9 0.3 7.9 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_029162.2_2 - 1.1e-11 44.2 42.3 0.0015 18.3 0.4 7.4 7 0 0 7 7 7 4 C2H2-type zinc finger zf-met PF12874.5 NM_029162.2_2 - 4.2e-10 39.5 33.7 0.0087 16.3 0.4 7.8 7 0 0 7 7 7 3 Zinc-finger of C2H2 type GAGA PF09237.9 NM_029162.2_2 - 2.5e-06 27.1 9.7 0.04 13.6 0.1 4.5 2 2 2 4 4 4 2 GAGA factor Zn-ribbon_8 PF09723.8 NM_029162.2_2 - 0.00039 20.3 24.0 0.25 11.4 3.6 4.9 3 1 0 4 4 4 3 Zinc ribbon domain FYVE PF01363.19 NM_029162.2_2 - 0.14 12.2 26.0 0.48 10.5 8.3 4.0 1 1 1 2 2 2 0 FYVE zinc finger zf-C2H2_8 PF15909.3 NM_029162.2_2 - 0.23 11.6 16.3 0.35 11.1 0.9 3.9 1 1 2 3 3 3 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.3 NM_029162.2_2 - 0.33 10.6 39.4 0.1 12.2 0.7 7.1 8 0 0 8 8 8 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_029162.2_2 - 0.54 10.9 19.2 2.1 9.0 0.4 4.3 1 1 5 6 6 6 0 zinc-ribbon family BolA PF01722.16 NM_029162.2_2 - 0.92 9.7 10.2 3.7 7.8 0.2 3.8 3 1 0 3 3 3 0 BolA-like protein ARS2 PF04959.11 NM_029162.2_2 - 1.2 9.3 10.7 9.9 6.4 0.1 3.8 1 1 0 3 3 3 0 Arsenite-resistance protein 2 zf-RING_7 PF02591.13 NM_029162.2_2 - 6.6 6.9 12.0 1.1 9.3 0.0 4.6 5 0 0 5 5 4 0 C4-type zinc ribbon domain Endomucin PF07010.10 NM_001163522.1_1 - 4.3e-108 361.1 24.8 5.7e-108 360.7 24.8 1.2 1 0 0 1 1 1 1 Endomucin DUF2207 PF09972.7 NM_001163522.1_1 - 0.059 12.0 0.1 0.088 11.4 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) IPP-2 PF04979.12 NM_001163522.1_1 - 2.4 8.8 5.8 0.31 11.7 0.9 1.9 2 0 0 2 2 2 0 Protein phosphatase inhibitor 2 (IPP-2) ABC1 PF03109.14 NM_001277296.1_3 - 1.7e-39 134.5 0.1 2.5e-39 134.0 0.1 1.3 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.23 NM_001277296.1_3 - 2.1e-06 27.2 0.1 0.00016 21.0 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.21 NM_001277296.1_3 - 0.00065 19.6 0.1 0.17 11.7 0.1 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family Neur_chan_LBD PF02931.21 NM_009603.1_2 - 2.4e-63 213.3 0.0 3.5e-63 212.8 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_009603.1_2 - 7.1e-57 193.1 0.0 1.1e-56 192.4 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF3377 PF11857.6 NM_009603.1_2 - 6.9 6.5 7.2 8.8 6.2 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) MCM PF00493.21 NM_001291054.1_2 - 1.8e-125 418.3 0.0 2.4e-125 417.9 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 NM_001291054.1_2 - 3.8e-25 88.0 0.4 6.4e-25 87.3 0.4 1.3 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.19 NM_001291054.1_2 - 8e-08 31.8 0.0 0.00014 21.2 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 NM_001291054.1_2 - 2.6e-07 30.6 0.0 6.3e-07 29.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.9 NM_001291054.1_2 - 5.3e-05 22.9 0.0 0.00022 20.9 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 NM_001291054.1_2 - 0.045 14.0 0.0 0.2 11.9 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.13 NM_001291054.1_2 - 0.049 13.4 1.1 1.4 8.7 0.1 2.8 3 0 0 3 3 3 0 NTPase AAA PF00004.27 NM_001291054.1_2 - 0.059 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.16 NM_001291054.1_2 - 0.1 11.8 0.0 0.31 10.2 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family EMI PF07546.11 NM_001289601.1_1 - 3.7e-06 27.5 1.9 1.7e-05 25.4 1.9 2.2 1 0 0 1 1 1 1 EMI domain Laminin_EGF PF00053.22 NM_001289601.1_3 - 7.7e-31 105.9 233.8 0.00022 21.2 14.4 14.3 6 4 8 14 14 14 11 Laminin EGF domain hEGF PF12661.5 NM_001289601.1_3 - 0.00013 22.4 52.1 0.0014 19.1 2.0 19.4 18 4 3 21 21 21 10 Human growth factor-like EGF EGF_2 PF07974.11 NM_001289601.1_3 - 0.00029 21.0 276.2 0.0031 17.7 15.1 20.3 16 8 0 16 16 16 9 EGF-like domain EGF PF00008.25 NM_001289601.1_3 - 0.005 17.0 14.9 0.005 17.0 14.9 18.0 17 1 0 17 17 17 7 EGF-like domain MOZ_SAS PF01853.16 NM_001199249.1_3 - 5.3e-54 182.4 0.6 8.8e-54 181.7 0.6 1.3 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.6 NM_001199249.1_3 - 1.3e-18 66.4 0.1 2.9e-18 65.4 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.5 NM_001199249.1_3 - 0.00086 19.6 0.0 0.0016 18.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 NM_001199249.1_3 - 0.013 15.6 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family KH_1 PF00013.27 NM_028307.1_3 - 9.1e-34 115.0 5.7 2.7e-16 59.0 0.4 2.4 2 0 0 2 2 2 2 KH domain TUDOR PF00567.22 NM_028307.1_3 - 3.7e-29 101.1 0.0 5.8e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 Tudor domain KH_2 PF07650.15 NM_028307.1_3 - 1.6e-07 30.9 2.8 0.0048 16.6 0.4 2.7 2 0 0 2 2 2 2 KH domain KH_4 PF13083.4 NM_028307.1_3 - 7.5e-06 25.6 0.8 0.028 14.2 0.0 2.6 2 0 0 2 2 2 2 KH domain KH_5 PF13184.4 NM_028307.1_3 - 0.031 14.2 0.9 8.3 6.4 0.1 2.3 2 0 0 2 2 2 0 NusA-like KH domain HD-ZIP_N PF04618.10 NM_001271690.1_1 - 1.4 9.4 9.5 6.3 7.2 0.1 3.5 3 0 0 3 3 3 0 HD-ZIP protein N terminus IRK PF01007.18 NM_001271690.1_3 - 1.4e-135 451.4 2.7 1.9e-135 450.9 2.7 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_001271690.1_3 - 0.017 15.0 3.8 0.047 13.5 3.8 1.8 1 0 0 1 1 1 0 Ion channel DUF2182 PF09948.7 NM_001271690.1_3 - 0.068 12.9 0.4 0.18 11.6 0.4 1.6 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) HD-ZIP_N PF04618.10 NM_001271690.1_3 - 0.16 12.3 0.3 8 6.9 0.0 2.5 2 0 0 2 2 2 0 HD-ZIP protein N terminus zf-CSL PF05207.11 NM_172254.4_2 - 5.4e-23 80.4 1.6 1.2e-22 79.3 1.6 1.6 1 0 0 1 1 1 1 CSL zinc finger TNF PF00229.16 NM_001159503.2_3 - 2.1e-20 72.8 0.0 2.1e-10 40.5 0.0 2.3 2 0 0 2 2 2 2 TNF(Tumour Necrosis Factor) family C1q PF00386.19 NM_001159503.2_3 - 0.0005 20.1 0.0 0.027 14.6 0.0 2.2 2 0 0 2 2 2 1 C1q domain DIRP PF06584.11 NM_001103182.2_2 - 5.9e-47 158.1 0.2 1.2e-46 157.1 0.2 1.5 1 0 0 1 1 1 1 DIRP FTA4 PF13093.4 NM_001103182.2_2 - 0.028 14.2 0.2 0.075 12.8 0.2 1.7 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF2664 PF10867.6 NM_001103182.2_2 - 0.074 13.4 0.3 0.18 12.1 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2664) ApoL PF05461.9 NM_001024848.2_2 - 1.1e-130 435.5 21.3 2.1e-119 398.4 11.6 2.0 1 1 1 2 2 2 2 Apolipoprotein L Chlorosome_CsmC PF11098.6 NM_001024848.2_2 - 0.14 12.0 2.4 0.26 11.2 2.4 1.4 1 0 0 1 1 1 0 Chlorosome envelope protein C MotA_ExbB PF01618.14 NM_001024848.2_2 - 0.37 10.5 2.3 1.5 8.5 2.3 2.0 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family Lactamase_B PF00753.25 NM_145381.2_3 - 1.8e-17 63.9 0.0 2.5e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 NM_145381.2_3 - 3.2e-05 23.4 0.0 5.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain UCH PF00443.27 NM_198092.2_2 - 4e-72 242.7 0.0 5.7e-72 242.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_198092.2_2 - 2e-18 66.9 0.0 2.9e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CENP-M PF11111.6 NM_178269.3_1 - 5.3e-11 41.9 0.0 7.7e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 Centromere protein M (CENP-M) CENP-M PF11111.6 NM_178269.3_3 - 2.3e-48 163.5 0.1 3.2e-48 163.1 0.1 1.1 1 0 0 1 1 1 1 Centromere protein M (CENP-M) Inhibitor_Mig-6 PF11555.6 NM_133753.1_3 - 3.6e-14 52.5 9.7 3.6e-14 52.5 9.7 3.2 3 0 0 3 3 3 1 EGFR receptor inhibitor Mig-6 GTPase_binding PF09027.8 NM_133753.1_3 - 5.6e-05 22.9 0.0 0.00012 21.9 0.0 1.5 1 0 0 1 1 1 1 GTPase binding Folate_carrier PF01770.16 NM_030556.2_2 - 1.3e-174 580.7 19.9 1.6e-174 580.4 19.9 1.1 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.14 NM_030556.2_2 - 2e-15 56.5 9.9 2e-15 56.5 9.9 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Zip PF02535.20 NM_144808.4_1 - 2e-67 227.7 7.6 3.5e-67 226.9 7.6 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter Kinesin PF00225.21 NM_053173.2_1 - 1.2e-93 313.5 0.0 1.7e-93 313.0 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 NM_053173.2_1 - 5.4e-51 172.3 0.0 9.9e-51 171.5 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding CENP-F_leu_zip PF10473.7 NM_053173.2_1 - 1.6e-06 28.0 21.9 1.6e-06 28.0 21.9 2.3 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.12 NM_053173.2_1 - 0.004 16.8 32.4 0.043 13.5 11.0 2.4 1 1 1 2 2 2 2 IncA protein Filament PF00038.19 NM_053173.2_1 - 0.0082 15.6 20.5 0.015 14.8 20.5 1.4 1 0 0 1 1 1 1 Intermediate filament protein C2-set PF05790.13 NM_053173.2_1 - 0.029 14.4 0.9 0.16 12.1 0.8 2.2 2 0 0 2 2 2 0 Immunoglobulin C2-set domain DUF2312 PF10073.7 NM_053173.2_1 - 0.085 12.4 4.7 0.16 11.5 1.9 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) ATG16 PF08614.9 NM_053173.2_1 - 0.19 11.8 32.3 0.17 11.9 26.6 2.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.10 NM_053173.2_1 - 0.2 10.9 0.7 0.46 9.7 0.7 1.6 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Spc7 PF08317.9 NM_053173.2_1 - 0.29 9.8 22.9 0.28 9.9 21.4 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein PI3K_P85_iSH2 PF16454.3 NM_053173.2_1 - 0.3 10.5 15.8 1.2 8.5 4.4 2.4 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Myosin_tail_1 PF01576.17 NM_053173.2_1 - 0.45 8.1 28.6 0.65 7.6 28.6 1.1 1 0 0 1 1 1 0 Myosin tail DUF724 PF05266.12 NM_053173.2_1 - 0.54 9.9 12.4 0.24 11.1 9.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Phage_Nu1 PF07471.10 NM_053173.2_1 - 0.67 9.6 3.8 1.6 8.4 3.8 1.7 1 0 0 1 1 1 0 Phage DNA packaging protein Nu1 GAS PF13851.4 NM_053173.2_1 - 0.69 9.1 21.4 5.3 6.2 20.3 2.3 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF2353 PF09789.7 NM_053173.2_1 - 0.7 9.1 20.3 4.6 6.4 9.4 2.2 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) SYCE1 PF15233.4 NM_053173.2_1 - 0.89 9.5 26.0 0.76 9.7 23.7 2.0 1 1 1 2 2 2 0 Synaptonemal complex central element protein 1 HOOK PF05622.10 NM_053173.2_1 - 1 7.3 22.5 1.8 6.5 22.5 1.3 1 0 0 1 1 1 0 HOOK protein SlyX PF04102.10 NM_053173.2_1 - 1 9.9 25.3 0.97 10.0 1.5 3.6 2 1 1 3 3 3 0 SlyX Macoilin PF09726.7 NM_053173.2_1 - 1.8 6.9 12.2 2.5 6.4 12.2 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF972 PF06156.11 NM_053173.2_1 - 2 8.9 20.0 1.3 9.5 3.6 4.4 3 1 1 5 5 4 0 Protein of unknown function (DUF972) DUF4407 PF14362.4 NM_053173.2_1 - 2.6 7.2 9.9 5.5 6.1 9.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KxDL PF10241.7 NM_053173.2_1 - 3.2 7.9 0.0 3.2 7.9 0.0 3.4 2 1 1 3 3 3 0 Uncharacterized conserved protein APG6 PF04111.10 NM_053173.2_1 - 4 6.6 26.0 1.7 7.8 7.7 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 Exonuc_VII_L PF02601.13 NM_053173.2_1 - 6.7 6.0 11.7 17 4.7 11.7 1.7 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF342 PF03961.11 NM_053173.2_1 - 9.7 4.5 9.1 13 4.1 8.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Innexin PF00876.16 NM_172454.2_3 - 1.4e-09 37.6 0.6 2.2e-09 37.0 0.6 1.2 1 0 0 1 1 1 1 Innexin Collagen PF01391.16 NM_053185.2_3 - 1.7e-185 600.9 629.4 2.6e-09 36.5 19.7 26.6 8 7 17 25 25 25 25 Collagen triple helix repeat (20 copies) C4 PF01413.17 NM_053185.2_3 - 7.1e-80 264.5 4.7 7.1e-43 145.4 0.3 2.2 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen MBD_C PF14048.4 NM_001306143.1_1 - 8.9e-34 115.9 0.0 1.9e-33 114.9 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of methyl-CpG binding protein 2 and 3 MBDa PF16564.3 NM_001306143.1_1 - 1.5e-28 98.7 1.0 2.9e-28 97.7 1.0 1.5 1 0 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD MBD PF01429.17 NM_001306143.1_1 - 1.5e-07 30.8 0.2 0.00099 18.6 0.0 2.5 2 0 0 2 2 2 2 Methyl-CpG binding domain RasGAP PF00616.17 NM_001306143.1_1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase HCO3_cotransp PF00955.19 NM_001242380.1_2 - 4.8e-247 820.7 6.2 6.3e-247 820.3 6.2 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 NM_001242380.1_2 - 2.1e-105 352.2 0.0 3.2e-105 351.6 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Chorein_N PF12624.5 NM_029166.2_3 - 1e-18 67.4 0.1 7.2e-18 64.7 0.1 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.3 NM_029166.2_3 - 0.0074 16.0 1.2 0.0074 16.0 1.2 2.7 3 1 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal CARD PF00619.19 NM_001037747.1_1 - 3.7e-19 68.4 0.0 3.7e-19 68.4 0.0 2.9 4 0 0 4 4 4 1 Caspase recruitment domain CARD_2 PF16739.3 NM_001037747.1_1 - 0.0004 20.2 0.1 0.0024 17.7 0.0 2.5 2 0 0 2 2 2 1 Caspase recruitment domain DUF4287 PF14117.4 NM_001037747.1_1 - 0.16 12.0 0.4 1.5 8.9 0.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4287) L_lactis_ph-MCP PF06673.9 NM_001037747.1_1 - 0.62 8.9 5.1 1 8.1 0.8 2.2 2 0 0 2 2 2 0 Lactococcus lactis bacteriophage major capsid protein Metal_resist PF13801.4 NM_001037747.1_1 - 3.5 7.7 16.0 0.96 9.5 3.6 4.0 2 1 1 3 3 3 0 Heavy-metal resistance BMP2K_C PF15282.4 NM_177762.6_2 - 6.2e-39 134.3 13.0 1.7e-37 129.6 13.0 2.3 1 1 0 1 1 1 1 BMP-2-inducible protein kinase C-terminus Pkinase PF00069.23 NM_177762.6_3 - 4.8e-42 144.0 0.0 6.7e-42 143.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_177762.6_3 - 1.2e-24 86.9 0.0 1.8e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_177762.6_3 - 1.8e-05 24.1 0.0 2.8e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 NM_177762.6_3 - 0.1 12.4 0.1 0.6 9.8 0.2 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF4483 PF14825.4 NM_001166705.1_2 - 2e-49 167.3 0.0 3.1e-49 166.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4483) CLCA PF08434.9 NM_001166705.1_2 - 0.057 11.2 0.0 0.077 10.8 0.0 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel Glyco_transf_8 PF01501.18 NM_013755.3_2 - 1.5e-18 67.2 0.1 2.1e-16 60.1 0.1 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.6 NM_013755.3_2 - 0.019 14.2 0.0 0.027 13.6 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative SdpI PF13630.4 NM_180962.2_2 - 0.13 12.3 0.4 0.13 12.3 0.4 2.5 2 0 0 2 2 2 0 SdpI/YhfL protein family Crystall PF00030.17 NM_007774.3_3 - 3.3e-63 209.7 5.2 1.9e-32 111.1 2.2 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin UCH PF00443.27 NM_001290994.1_2 - 8.3e-48 163.0 0.2 1.3e-47 162.3 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_N PF16674.3 NM_001290994.1_2 - 1.6e-33 114.7 0.2 3.2e-33 113.7 0.2 1.5 1 0 0 1 1 1 1 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 UCH_1 PF13423.4 NM_001290994.1_2 - 3.1e-18 66.3 2.4 8.6e-14 51.7 1.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase BTB PF00651.29 NM_001039059.1_2 - 2.5e-23 82.3 1.9 2.5e-23 82.3 1.9 1.6 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.13 NM_001039059.1_2 - 2.8e-15 56.1 0.1 5.7e-15 55.1 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch MRP-L27 PF09809.7 NM_001031808.2_1 - 7.4e-43 144.8 0.2 1e-42 144.4 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 Pkinase PF00069.23 NM_012040.3_2 - 2.5e-75 253.1 0.0 3e-75 252.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_012040.3_2 - 1e-34 119.9 0.0 1.2e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_012040.3_2 - 2.7e-06 26.8 0.0 3.7e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_012040.3_2 - 0.0015 17.8 0.0 0.0027 17.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_012040.3_2 - 0.077 12.8 0.0 1.4 8.6 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.20 NM_012040.3_2 - 0.16 11.5 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 RIO1 family 7tm_4 PF13853.4 NM_001005488.1_1 - 1.5e-51 175.6 21.5 1.8e-51 175.4 21.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005488.1_1 - 2.5e-23 82.5 22.7 6.2e-23 81.2 22.7 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001005488.1_1 - 2.8e-06 26.8 19.6 6e-06 25.7 19.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx GRDA PF04723.12 NM_001005488.1_1 - 0.11 12.2 0.1 0.22 11.1 0.1 1.5 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A NDUF_B6 PF09782.7 NM_001033305.3_1 - 5.8e-51 172.6 0.9 6.9e-51 172.3 0.9 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit WD40 PF00400.30 NM_001081477.1_2 - 2.1e-34 116.8 20.9 5.6e-06 26.9 0.4 8.7 8 0 0 8 8 8 7 WD domain, G-beta repeat Bromodomain PF00439.23 NM_001081477.1_2 - 1.4e-33 114.7 3.0 2e-18 66.1 0.0 3.5 2 1 0 2 2 2 2 Bromodomain ANAPC4_WD40 PF12894.5 NM_001081477.1_2 - 0.00054 20.1 0.4 0.92 9.7 0.3 4.8 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Auxin_resp PF06507.11 NM_001081477.1_2 - 0.053 13.6 0.1 0.15 12.2 0.1 1.8 1 0 0 1 1 1 0 Auxin response factor G6PD_C PF02781.14 NM_019468.2_3 - 3.4e-113 377.5 0.0 1.2e-112 375.8 0.0 1.7 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.20 NM_019468.2_3 - 2.2e-58 197.6 0.1 7.4e-58 196.0 0.0 1.9 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain LRR_8 PF13855.4 NM_007689.4_1 - 1.3e-46 156.1 22.4 1.2e-18 66.4 0.2 5.2 3 2 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 NM_007689.4_1 - 6.1e-22 77.1 25.0 1.1e-05 25.5 0.1 6.4 4 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_007689.4_1 - 2.4e-15 56.5 0.0 2.1e-06 27.6 0.0 3.0 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_1 PF00560.31 NM_007689.4_1 - 1.4e-07 30.8 23.6 1.8 9.2 0.1 10.6 10 1 0 10 10 10 1 Leucine Rich Repeat LRRNT PF01462.16 NM_007689.4_1 - 1.6e-07 30.7 3.0 1.6e-07 30.7 3.0 2.5 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 NM_007689.4_1 - 2.7e-06 26.9 5.1 0.0032 16.9 0.2 3.4 1 1 3 4 4 4 3 Leucine-rich repeat LRRCT PF01463.22 NM_007689.4_1 - 0.0061 16.9 0.0 0.023 15.1 0.0 2.1 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain Chorein_N PF12624.5 NM_007689.4_1 - 0.095 12.7 0.2 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 N-terminal region of Chorein or VPS13 RNA_pol_Rbc25 PF08292.10 NM_030229.4_3 - 5.4e-42 142.9 0.0 8e-42 142.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.15 NM_030229.4_3 - 4.1e-19 68.6 0.0 7.6e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Pyridoxal_deC PF00282.17 NM_001312900.1_2 - 3.8e-16 58.6 0.0 5.1e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain bZIP_1 PF00170.19 NM_001311066.1_1 - 1.1e-18 67.0 13.0 1.8e-18 66.3 13.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001311066.1_1 - 6.4e-07 29.2 13.6 1.1e-06 28.4 13.6 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001311066.1_1 - 0.039 14.3 6.7 0.067 13.6 6.7 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor bZIP_1 PF00170.19 NM_001311066.1_2 - 2.4e-15 56.2 4.4 4.3e-15 55.4 4.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001311066.1_2 - 3.4e-05 23.7 5.1 5.2e-05 23.1 5.1 1.3 1 0 0 1 1 1 1 Basic region leucine zipper REC114-like PF15165.4 NM_028598.1_3 - 1.8e-101 338.8 0.0 2e-101 338.6 0.0 1.0 1 0 0 1 1 1 1 Meiotic recombination protein REC114-like RA PF00788.21 NM_001243748.1_1 - 1.7e-18 66.9 0.1 3.8e-18 65.8 0.1 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.3 NM_001243748.1_1 - 3.7e-18 65.1 4.7 7.1e-18 64.2 4.7 1.5 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain C1_1 PF00130.20 NM_001243748.1_1 - 1.3e-07 31.2 14.2 2.6e-07 30.3 14.2 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Mst1_SARAH PF11629.6 NM_001243748.1_1 - 0.017 15.1 0.9 0.053 13.5 0.9 1.8 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 Plectin PF00681.18 NM_201389.2_1 - 4e-297 957.8 37.1 5.2e-21 74.1 0.0 29.8 26 5 6 32 32 32 26 Plectin repeat CH PF00307.29 NM_201389.2_1 - 2.6e-47 159.4 0.2 1.7e-22 79.5 0.2 3.3 2 0 0 2 2 2 2 Calponin homology (CH) domain S10_plectin PF03501.13 NM_201389.2_1 - 1.9e-36 123.9 0.3 1.5e-35 121.1 0.0 2.7 2 0 0 2 2 2 1 Plectin/S10 domain CAMSAP_CH PF11971.6 NM_201389.2_1 - 3.2e-05 23.5 0.1 0.017 14.8 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain Imm70 PF15601.4 NM_201389.2_1 - 0.8 9.1 3.7 0.92 8.9 0.0 3.2 3 0 0 3 3 3 0 Immunity protein 70 Spore_YhaL PF14147.4 NM_201389.2_1 - 7.7 6.2 8.2 72 3.1 8.2 2.9 1 0 0 1 1 1 0 Sporulation protein YhaL Syntaxin-6_N PF09177.9 NM_021433.3_2 - 2.5e-37 127.3 0.3 2.5e-37 127.3 0.3 2.1 2 1 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.17 NM_021433.3_2 - 3.9e-12 45.9 1.0 3.9e-12 45.9 1.0 1.7 2 0 0 2 2 2 1 SNARE domain FliD_C PF07195.10 NM_021433.3_2 - 0.0048 16.2 0.9 0.22 10.8 0.0 2.3 2 1 0 2 2 2 1 Flagellar hook-associated protein 2 C-terminus Pox_EPC_I2-L1 PF12575.6 NM_021433.3_2 - 0.23 11.6 0.5 0.47 10.6 0.5 1.5 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 Prominin PF05478.9 NM_021433.3_2 - 0.59 7.9 3.4 1.6 6.4 3.1 1.6 1 1 1 2 2 2 0 Prominin TBPIP PF07106.11 NM_021433.3_2 - 7.1 6.2 6.5 1.6 8.3 0.2 2.1 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TAF1D PF15333.4 NM_175312.4_1 - 0.2 11.2 6.7 0.33 10.5 6.7 1.2 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D Bmt2 PF11968.6 NM_175312.4_2 - 0.0016 18.2 8.4 0.0016 18.2 0.3 2.5 2 1 1 3 3 3 2 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Coilin_N PF15862.3 NM_175312.4_3 - 0.0015 18.2 1.2 0.0026 17.4 1.2 1.3 1 0 0 1 1 1 1 Coilin N-terminus AP3D1 PF06375.9 NM_175312.4_3 - 6.1 7.0 15.0 9.7 6.3 15.0 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Vps16_C PF04840.10 NM_001142581.1_1 - 3.3e-12 46.0 2.5 2.8e-06 26.5 0.2 2.1 2 0 0 2 2 2 2 Vps16, C-terminal region CEP209_CC5 PF16574.3 NM_001142581.1_1 - 0.12 12.4 1.1 0.6 10.2 0.1 2.2 2 0 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 DUF1899 PF08953.9 NM_139130.2_1 - 1.1e-30 105.1 0.0 2.4e-30 104.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 NM_139130.2_1 - 3.8e-22 77.7 0.2 1e-21 76.4 0.2 1.8 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 NM_139130.2_1 - 3.3e-16 59.2 8.1 5e-05 23.9 0.3 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_139130.2_1 - 1.2e-09 38.2 0.2 0.00092 19.3 0.0 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Trimer_CC PF08954.9 NM_139130.2_1 - 0.0061 16.0 1.9 0.67 9.4 1.9 2.4 2 0 0 2 2 2 1 Trimerisation motif Coatomer_WDAD PF04053.12 NM_139130.2_1 - 0.069 12.1 0.0 0.09 11.7 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region PALB2_WD40 PF16756.3 NM_139130.2_1 - 0.08 11.7 0.1 0.22 10.3 0.0 1.6 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain DUF4140 PF13600.4 NM_139130.2_1 - 0.14 12.4 0.5 0.28 11.5 0.5 1.4 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Serinc PF03348.13 NM_172588.2_1 - 2.4e-150 501.1 26.3 3.5e-150 500.5 26.3 1.2 1 0 0 1 1 1 1 Serine incorporator (Serinc) Glyco_transf_7N PF13733.4 NM_019835.2_3 - 9.8e-54 180.5 0.0 1.5e-53 179.9 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 NM_019835.2_3 - 2.6e-28 97.3 0.4 2.6e-28 97.3 0.4 2.0 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase 7tm_1 PF00001.19 NM_016977.4_1 - 4.8e-30 104.5 37.3 1.8e-29 102.7 37.3 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_016977.4_1 - 5.1e-10 39.4 21.3 1.1e-07 31.7 21.3 2.5 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 NM_016977.4_1 - 8.3e-10 38.3 31.4 1.8e-09 37.2 31.4 1.6 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF737 PF05300.9 NM_001167736.1_3 - 1.2e-30 107.3 8.6 1.1e-26 94.3 3.5 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF737) CHCH PF06747.11 NM_001167736.1_3 - 8.7e-06 25.6 0.2 1.7e-05 24.7 0.2 1.5 1 0 0 1 1 1 1 CHCH domain NDUF_B7 PF05676.11 NM_001167736.1_3 - 0.055 13.1 0.8 0.13 11.9 0.8 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF342 PF03961.11 NM_001167736.1_3 - 0.11 11.0 1.0 0.14 10.6 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Activator-TraM PF11657.6 NM_001167736.1_3 - 0.23 11.2 5.0 0.36 10.5 5.0 1.3 1 0 0 1 1 1 0 Transcriptional activator TraM AAA PF00004.27 NM_011835.2_3 - 4.4e-39 133.8 0.0 1.1e-38 132.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 NM_011835.2_3 - 2.5e-09 36.8 0.1 9.6e-09 35.0 0.0 2.1 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_2 PF07724.12 NM_011835.2_3 - 2.5e-05 24.3 0.0 4.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.4 NM_011835.2_3 - 3.3e-05 23.9 0.0 0.00021 21.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.10 NM_011835.2_3 - 3.4e-05 23.1 0.0 8.1e-05 21.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.15 NM_011835.2_3 - 0.00018 21.2 0.0 0.008 15.8 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_5 PF07728.12 NM_011835.2_3 - 0.0002 21.2 0.2 0.0014 18.5 0.2 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.11 NM_011835.2_3 - 0.0013 17.6 0.0 0.0024 16.8 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus Mg_chelatase PF01078.19 NM_011835.2_3 - 0.0038 16.5 0.0 0.0085 15.4 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.4 NM_011835.2_3 - 0.0054 17.0 0.1 0.012 15.8 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.4 NM_011835.2_3 - 0.0062 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 NM_011835.2_3 - 0.0067 16.6 0.3 0.078 13.1 0.3 2.6 1 1 0 1 1 1 1 AAA domain TsaE PF02367.15 NM_011835.2_3 - 0.0077 16.1 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.11 NM_011835.2_3 - 0.015 14.5 0.2 1.3 8.1 0.1 2.7 1 1 1 2 2 2 0 KaiC PhoH PF02562.14 NM_011835.2_3 - 0.028 13.8 0.1 0.062 12.6 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.4 NM_011835.2_3 - 0.041 14.3 0.6 0.2 12.0 0.6 2.2 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 NM_011835.2_3 - 0.078 13.2 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase TPR_1 PF00515.26 NM_011835.2_3 - 0.1 12.3 0.2 0.66 9.8 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_011835.2_3 - 0.11 12.5 1.0 1.3 9.1 0.3 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 NM_011835.2_3 - 0.12 12.5 0.6 0.47 10.7 0.1 2.3 2 0 0 2 2 1 0 Tetratricopeptide repeat ABC_tran PF00005.25 NM_011835.2_3 - 0.13 12.6 0.2 0.52 10.7 0.0 2.1 2 1 0 2 2 2 0 ABC transporter Guanylate_kin PF00625.19 NM_011835.2_3 - 0.62 9.6 2.8 1.2 8.7 0.0 2.7 4 0 0 4 4 4 0 Guanylate kinase LRR_4 PF12799.5 NM_029948.2_1 - 0.27 11.6 11.6 0.92 9.9 0.4 4.7 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_029948.2_1 - 0.83 10.2 6.1 29 5.6 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat zf-H2C2_2 PF13465.4 NM_001166497.1_1 - 1.6e-62 205.2 105.9 1.3e-09 37.9 1.2 12.8 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001166497.1_1 - 4.1e-44 146.5 114.4 4.2e-06 26.8 3.0 12.5 13 0 0 13 13 13 10 Zinc finger, C2H2 type KRAB PF01352.25 NM_001166497.1_1 - 5.9e-23 80.1 0.8 1.1e-22 79.3 0.8 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001166497.1_1 - 6.7e-20 69.9 105.3 0.0088 16.7 2.6 12.3 12 0 0 12 12 12 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001166497.1_1 - 6.6e-13 48.1 82.8 0.00037 20.3 0.8 10.8 10 0 0 10 10 10 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001166497.1_1 - 0.017 15.1 56.1 0.087 12.8 4.0 7.6 2 2 5 8 8 8 0 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001166497.1_1 - 0.018 15.2 69.7 0.045 14.0 1.9 9.8 10 0 0 10 10 10 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001166497.1_1 - 0.46 10.8 78.3 0.091 13.0 1.4 9.5 9 0 0 9 9 9 0 Zinc-finger of C2H2 type HJURP_mid PF12346.6 NM_198652.2_3 - 1.1e-49 167.6 4.9 2.8e-49 166.3 4.9 1.8 1 0 0 1 1 1 1 Holliday junction recognition protein-associated repeat HJURP_C PF12347.6 NM_198652.2_3 - 4.9e-42 141.6 0.4 3.6e-22 78.0 0.1 2.9 2 0 0 2 2 2 2 Holliday junction regulator protein family C-terminal repeat Scm3 PF10384.7 NM_198652.2_3 - 2.2e-06 27.2 0.0 4.1e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Centromere protein Scm3 TFIIE_beta PF02186.13 NM_001167922.1_2 - 4.4e-24 84.4 1.3 1e-23 83.2 0.2 2.1 2 0 0 2 2 2 1 TFIIE beta subunit core domain WRNPLPNID PF15017.4 NM_177640.4_2 - 4.8e-06 27.2 0.2 8.8e-06 26.4 0.2 1.4 1 0 0 1 1 1 1 Putative WW-binding domain and destruction box TPR_1 PF00515.26 NM_001291155.1_2 - 1.7e-26 90.8 15.7 1.2e-07 31.1 0.1 6.3 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001291155.1_2 - 1.9e-22 77.4 14.7 2.8e-05 23.8 0.1 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001291155.1_2 - 2e-10 40.7 14.0 0.031 14.4 0.4 5.5 3 2 1 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001291155.1_2 - 2.9e-09 36.3 15.3 0.0032 17.0 0.6 4.6 4 0 0 4 4 4 3 TPR repeat TPR_8 PF13181.4 NM_001291155.1_2 - 6.9e-09 35.1 13.4 0.05 13.7 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001291155.1_2 - 6.4e-07 29.7 2.0 0.0042 17.4 0.2 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_001291155.1_2 - 1.9e-06 27.7 5.3 4e-05 23.5 0.3 3.4 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.4 NM_001291155.1_2 - 7.1e-05 22.8 8.3 0.036 14.3 0.2 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001291155.1_2 - 0.00011 22.6 7.1 0.33 11.7 0.4 4.9 4 1 1 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001291155.1_2 - 0.00013 22.0 15.6 0.018 15.1 6.9 2.6 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.4 NM_001291155.1_2 - 0.0011 18.6 0.8 1.6 8.6 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001291155.1_2 - 0.0042 17.1 2.6 1.8 8.6 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.16 NM_001291155.1_2 - 0.0055 16.6 13.5 0.9 9.5 0.3 5.2 4 1 1 5 5 5 1 MIT (microtubule interacting and transport) domain TPR_16 PF13432.4 NM_001291155.1_2 - 0.035 14.7 0.0 0.16 12.5 0.1 3.6 3 1 1 4 4 3 0 Tetratricopeptide repeat BTAD PF03704.15 NM_001291155.1_2 - 0.039 14.3 0.9 15 5.9 0.1 3.0 2 1 0 2 2 2 0 Bacterial transcriptional activator domain DUF4919 PF16266.3 NM_001291155.1_2 - 0.046 13.5 0.1 0.36 10.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4919) SHNi-TPR PF10516.7 NM_001291155.1_2 - 0.088 12.2 4.1 4.1 6.8 0.0 3.8 4 0 0 4 4 4 0 SHNi-TPR TPR_7 PF13176.4 NM_001291155.1_2 - 0.23 11.4 11.0 14 5.9 0.2 5.1 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001291155.1_2 - 9 7.0 11.7 14 6.5 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat CH PF00307.29 NM_153396.3_1 - 4.2e-21 75.1 0.0 9.7e-21 73.9 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_153396.3_1 - 2.4e-13 49.6 0.0 5.8e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.20 NM_153396.3_1 - 2.7e-06 27.4 2.9 5.7e-06 26.3 2.9 1.6 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.17 NM_153396.3_1 - 7.1e-06 25.4 0.0 1.4e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.4 NM_153396.3_1 - 1.5e-05 24.2 0.1 5.1e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 NM_153396.3_1 - 6.8e-05 22.1 0.0 0.00013 21.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 NM_153396.3_1 - 0.00048 19.7 0.0 0.00082 19.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.4 NM_153396.3_1 - 0.001 19.3 0.0 0.0035 17.6 0.0 1.9 2 0 0 2 2 1 1 Putative NAD(P)-binding FAD_binding_2 PF00890.22 NM_153396.3_1 - 0.0011 18.0 0.0 0.002 17.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.12 NM_153396.3_1 - 0.0012 17.5 0.0 0.0021 16.7 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.4 NM_153396.3_1 - 0.0016 18.5 0.0 0.0044 17.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 NM_153396.3_1 - 0.0043 17.4 0.0 0.016 15.6 0.0 2.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.15 NM_153396.3_1 - 0.035 13.2 0.0 0.065 12.3 0.0 1.3 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.19 NM_153396.3_1 - 0.049 12.8 0.0 0.095 11.9 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.10 NM_153396.3_1 - 0.066 12.1 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pkinase PF00069.23 NM_001080389.2_1 - 4.8e-76 255.5 0.0 6.3e-76 255.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001080389.2_1 - 1.3e-44 152.4 0.0 2e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 NM_001080389.2_1 - 1.2e-20 72.9 0.0 2.7e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.4 NM_001080389.2_1 - 1.6e-06 27.5 0.0 3e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like UBA PF00627.29 NM_001080389.2_1 - 3.5e-05 23.5 0.0 5.8e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain UBA_2 PF08587.9 NM_001080389.2_1 - 0.0019 18.2 0.1 0.0038 17.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) RIO1 PF01163.20 NM_001080389.2_1 - 0.0019 17.7 0.3 0.0039 16.7 0.3 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 NM_001080389.2_1 - 0.022 14.0 0.1 0.039 13.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Melibiase_2 PF16499.3 NM_013463.2_3 - 3.3e-189 628.2 2.4 4e-189 627.9 2.4 1.1 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase PF02065.16 NM_013463.2_3 - 2.4e-05 23.3 0.0 5e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Melibiase AA_permease_2 PF13520.4 NM_001038660.2_1 - 1.8e-54 185.1 43.5 1.8e-54 185.1 43.5 1.5 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.19 NM_001038660.2_1 - 1.1e-18 67.0 39.2 1.6e-18 66.4 39.2 1.2 1 0 0 1 1 1 1 Amino acid permease Defensin_beta PF00711.17 NM_183038.2_1 - 1.7e-12 47.0 10.0 2.2e-12 46.7 10.0 1.1 1 0 0 1 1 1 1 Beta defensin RRM_1 PF00076.20 NM_145625.3_2 - 1.9e-12 46.7 0.0 3.1e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_145625.3_2 - 0.059 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif Na_H_Exchanger PF00999.19 NM_001033289.2_1 - 6e-93 311.5 43.8 7.3e-93 311.2 43.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.3 NM_001033289.2_1 - 1.6e-41 141.0 10.2 2.7e-41 140.2 10.2 1.4 1 0 0 1 1 1 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Fer4 PF00037.25 NM_144870.5_3 - 1.3e-13 50.0 17.5 2.8e-08 33.1 4.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.5 NM_144870.5_3 - 1.8e-12 47.5 10.5 3.5e-12 46.6 10.5 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.4 NM_144870.5_3 - 2.1e-10 41.3 6.8 7.1e-05 23.5 0.2 2.5 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.4 NM_144870.5_3 - 2.9e-08 33.6 10.3 5.1e-08 32.8 10.3 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.4 NM_144870.5_3 - 8.4e-08 32.1 32.2 1.8e-05 24.6 12.5 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.4 NM_144870.5_3 - 1.4e-07 31.4 21.4 9e-06 25.6 12.6 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.5 NM_144870.5_3 - 8.2e-07 28.7 17.8 0.00064 19.6 5.4 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.5 NM_144870.5_3 - 3.5e-06 26.7 12.1 0.0046 16.9 1.9 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.4 NM_144870.5_3 - 3.5e-06 27.2 19.0 0.00041 20.6 11.4 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.5 NM_144870.5_3 - 3.8e-05 23.7 12.3 0.00079 19.6 2.5 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.4 NM_144870.5_3 - 0.00062 20.1 11.9 0.059 13.8 12.9 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.8 NM_144870.5_3 - 0.018 15.2 5.8 0.85 9.8 0.5 2.4 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_18 PF13746.4 NM_144870.5_3 - 0.12 12.5 8.8 1.8 8.7 1.4 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.4 NM_144870.5_3 - 0.29 11.6 18.1 0.92 10.0 2.6 2.7 3 0 0 3 3 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.5 NM_144870.5_3 - 0.47 11.4 16.4 0.54 11.2 4.1 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_22 PF17179.2 NM_144870.5_3 - 2.9 8.7 12.2 4.2 8.1 1.8 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.11 NM_144870.5_3 - 3 7.9 8.1 2.7 8.1 0.7 2.6 2 1 1 3 3 3 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Homeobox PF00046.27 NM_008701.2_1 - 3.8e-19 68.1 8.2 7e-19 67.3 8.2 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_008701.2_1 - 0.036 13.9 0.1 0.077 12.8 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain Serpin PF00079.18 NM_011111.4_1 - 7.3e-126 420.3 1.0 8.8e-126 420.0 1.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) GDE_C PF06202.12 NM_011111.4_1 - 0.13 11.1 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase Filament PF00038.19 NM_010667.2_2 - 6.3e-95 318.2 29.0 7.4e-95 318.0 29.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 NM_010667.2_2 - 1.2e-12 48.2 2.3 1.2e-12 48.2 2.3 1.9 2 0 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 NM_010667.2_2 - 1.2e-05 25.2 27.2 0.00015 21.7 2.1 3.4 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein CALCOCO1 PF07888.9 NM_010667.2_2 - 0.11 11.0 23.3 0.12 10.8 10.9 2.1 1 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.9 NM_010667.2_2 - 0.12 11.0 22.8 0.17 10.6 11.0 2.8 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF1635 PF07795.9 NM_010667.2_2 - 0.16 11.8 3.9 0.29 11.0 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Spc42p PF11544.6 NM_010667.2_2 - 0.34 10.8 3.5 0.17 11.8 0.3 2.1 2 0 0 2 2 2 0 Spindle pole body component Spc42p MCC-bdg_PDZ PF10506.7 NM_010667.2_2 - 0.34 10.8 7.7 0.15 11.9 2.9 2.9 2 1 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF1759 PF03564.13 NM_010667.2_2 - 0.44 10.3 5.4 7.6 6.3 0.5 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1759) TSC22 PF01166.16 NM_010667.2_2 - 1.2 9.4 9.7 5.5 7.2 2.0 3.6 3 0 0 3 3 3 0 TSC-22/dip/bun family Prefoldin PF02996.15 NM_010667.2_2 - 1.3 8.9 8.3 2.4 8.0 0.2 3.6 2 1 0 3 3 3 0 Prefoldin subunit DivIC PF04977.13 NM_010667.2_2 - 1.7 8.3 13.5 0.17 11.5 3.0 3.2 3 1 0 3 3 3 0 Septum formation initiator DUF342 PF03961.11 NM_010667.2_2 - 1.8 6.9 8.9 1.9 6.8 4.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF342) CENP-F_leu_zip PF10473.7 NM_010667.2_2 - 1.9 8.4 27.1 1.7 8.6 4.7 4.1 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2205 PF10224.7 NM_010667.2_2 - 3.1 7.7 6.9 1.4 8.8 0.1 3.0 3 0 0 3 3 2 0 Predicted coiled-coil protein (DUF2205) BRE1 PF08647.9 NM_010667.2_2 - 4.3 7.4 13.6 1.5 8.8 2.0 3.3 2 2 1 3 3 3 0 BRE1 E3 ubiquitin ligase DASH_Duo1 PF08651.8 NM_010667.2_2 - 5.8 6.6 7.7 0.88 9.3 2.3 2.5 3 0 0 3 3 3 0 DASH complex subunit Duo1 DUF4472 PF14739.4 NM_010667.2_2 - 6.5 7.4 14.0 7.5 7.2 1.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4472) HIP1_clath_bdg PF16515.3 NM_010667.2_2 - 7.1 7.2 12.8 3 8.4 4.8 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ADIP PF11559.6 NM_010667.2_2 - 7.2 6.5 18.7 0.078 12.9 8.0 2.7 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding IFT20 PF14931.4 NM_010667.2_2 - 7.3 6.7 12.9 0.83 9.7 6.7 2.3 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Y_phosphatase PF00102.25 NM_011206.2_1 - 4.8e-76 255.3 0.0 6.1e-76 254.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 NM_011206.2_1 - 0.001 19.0 0.0 0.0015 18.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF2828 PF11443.6 NM_011206.2_1 - 0.02 13.0 0.0 0.029 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DSPc PF00782.18 NM_011206.2_1 - 0.14 11.8 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain fn2 PF00040.17 NM_001033418.4_2 - 2.3e-25 88.4 26.3 5.2e-15 55.3 10.1 2.3 2 0 0 2 2 2 2 Fibronectin type II domain UBA_4 PF14555.4 NM_001033418.4_3 - 0.09 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain WAP PF00095.19 NM_183271.2_1 - 9.9e-08 32.1 9.3 9.9e-08 32.1 9.3 1.6 2 0 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' La PF05383.15 NM_001080948.2_2 - 6e-17 61.3 0.3 1.2e-16 60.3 0.3 1.6 1 0 0 1 1 1 1 La domain ENTH PF01417.18 NM_001252454.1_2 - 7.4e-52 174.5 0.2 1.1e-51 174.0 0.2 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.14 NM_001252454.1_2 - 3.4e-05 22.8 0.3 4.7e-05 22.4 0.3 1.1 1 0 0 1 1 1 1 ANTH domain UIM PF02809.18 NM_001252454.1_2 - 0.00076 19.1 23.3 0.015 15.0 1.3 3.4 3 0 0 3 3 3 2 Ubiquitin interaction motif VHS PF00790.17 NM_001252454.1_2 - 0.0056 16.4 0.2 0.0085 15.8 0.2 1.2 1 0 0 1 1 1 1 VHS domain fn3 PF00041.19 NM_001081416.1_1 - 6e-39 132.1 10.9 1e-11 44.9 0.0 5.7 4 1 1 5 5 5 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_001081416.1_1 - 4.1e-11 43.2 18.3 0.0013 19.1 0.1 5.2 5 1 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 NM_001081416.1_1 - 6.2e-07 29.6 0.0 0.21 11.8 0.0 4.2 4 0 0 4 4 4 2 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.7 NM_001081416.1_1 - 0.00025 21.3 0.0 0.69 10.3 0.0 4.2 4 0 0 4 4 4 1 Uncharacterised conserved protein (DUF2369) Sterile PF03015.17 NM_001081416.1_1 - 0.15 12.1 0.0 19 5.4 0.0 2.3 2 0 0 2 2 2 0 Male sterility protein HIF-1a_CTAD PF08778.8 NM_001313689.1_1 - 0.096 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain SH2 PF00017.22 NM_001313689.1_3 - 1.6e-09 37.6 0.0 2.4e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 SH2 domain TSP_C PF05735.10 NM_013691.2_3 - 5e-96 320.2 0.3 6.6e-96 319.8 0.3 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 NM_013691.2_3 - 1.2e-58 194.3 133.9 2.3e-13 49.5 11.8 9.5 7 2 1 8 8 8 7 Thrombospondin type 3 repeat COMP PF11598.6 NM_013691.2_3 - 2e-19 69.6 4.3 4.2e-19 68.6 4.3 1.6 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein EGF_CA PF07645.13 NM_013691.2_3 - 5.2e-12 45.6 18.2 2.8e-07 30.5 1.2 5.5 5 0 0 5 5 5 2 Calcium-binding EGF domain cEGF PF12662.5 NM_013691.2_3 - 5.4e-09 35.7 24.8 0.00011 21.9 0.5 5.5 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_3 PF12947.5 NM_013691.2_3 - 5.2e-06 26.4 17.5 2.1e-05 24.5 3.4 6.7 4 3 0 5 5 5 3 EGF domain EGF PF00008.25 NM_013691.2_3 - 0.015 15.4 5.2 0.015 15.4 5.2 5.2 4 0 0 4 4 4 0 EGF-like domain DUF2012 PF09430.8 NM_133749.2_2 - 1.2e-33 115.7 0.0 1.7e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.4 NM_133749.2_2 - 0.042 14.0 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Pkinase PF00069.23 NM_001163432.2_1 - 6.7e-50 169.8 0.1 8.4e-50 169.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001163432.2_1 - 1.9e-20 73.1 0.0 3.8e-20 72.1 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Peptidase_M19 PF01244.19 NM_001301205.1_2 - 1.1e-107 359.7 0.0 1.4e-107 359.4 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Pyr_excise PF03013.12 NM_001301205.1_2 - 0.054 13.3 0.0 14 5.6 0.0 3.1 3 0 0 3 3 3 0 Pyrimidine dimer DNA glycosylase CD20 PF04103.13 NM_025658.4_2 - 1.2e-15 57.7 25.5 5.7e-15 55.6 16.0 2.2 1 1 1 2 2 2 2 CD20-like family Hol_Tox PF16935.3 NM_025658.4_2 - 0.41 10.4 0.0 0.41 10.4 0.0 3.0 3 1 1 4 4 4 0 Putative Holin-like Toxin (Hol-Tox) CENP-R PF06729.10 NM_026348.3_2 - 6.3e-59 197.7 7.4 8.7e-59 197.3 7.4 1.2 1 0 0 1 1 1 1 Kinetochore component, CENP-R ATP-gua_PtransN PF02807.13 NM_026348.3_2 - 0.12 12.6 0.5 0.22 11.8 0.5 1.4 1 0 0 1 1 1 0 ATP:guanido phosphotransferase, N-terminal domain EF-hand_7 PF13499.4 NM_001291276.1_3 - 7.9e-11 42.1 3.4 1.3e-10 41.4 2.1 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_001291276.1_3 - 2.9e-10 38.8 6.0 9.1e-05 21.6 0.1 3.3 3 1 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 NM_001291276.1_3 - 5.2e-09 35.2 3.9 0.0001 21.8 0.4 3.4 3 1 1 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 NM_001291276.1_3 - 2.5e-07 30.2 4.8 0.0039 16.8 1.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_001291276.1_3 - 5.7e-07 28.7 4.2 0.0059 15.9 0.5 2.9 2 1 1 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.7 NM_001291276.1_3 - 0.014 15.6 0.3 0.094 12.9 0.3 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_001291276.1_3 - 0.071 12.9 2.7 0.44 10.4 0.2 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand S_100 PF01023.17 NM_001291276.1_3 - 0.16 11.6 1.0 7.1 6.3 0.0 3.3 4 0 0 4 4 4 0 S-100/ICaBP type calcium binding domain DUF4196 PF13846.4 NM_025534.3_3 - 3.5e-46 156.1 11.1 3.5e-46 156.1 11.1 3.0 3 1 0 3 3 3 1 Domain of unknown function (DUF4196) DUF4211 PF13926.4 NM_025534.3_3 - 8.1e-31 106.9 1.0 1.9e-30 105.7 1.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) Dickkopf_N PF04706.10 NM_020265.4_1 - 9.5e-16 57.9 19.6 9.5e-16 57.9 19.6 3.3 3 1 0 3 3 3 2 Dickkopf N-terminal cysteine-rich region DUF4501 PF14946.4 NM_020265.4_1 - 0.24 11.3 5.8 0.65 9.9 5.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) NPR3 PF03666.11 NM_020265.4_2 - 0.46 9.1 14.0 0.78 8.3 14.0 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.10 NM_020265.4_2 - 1.8 8.2 18.6 3.2 7.4 18.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.15 NM_020265.4_2 - 5.9 6.8 8.2 11 5.9 8.2 1.3 1 0 0 1 1 1 0 DDHD domain DDHD PF02862.15 NM_020265.4_3 - 2.4 8.1 6.1 3.8 7.4 6.1 1.2 1 0 0 1 1 1 0 DDHD domain EMP24_GP25L PF01105.22 NM_134020.1_2 - 1.1e-51 175.2 0.0 1.5e-51 174.8 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RNA_pol_A_bac PF01000.24 NM_009090.5_2 - 1.1e-39 135.1 0.0 1.8e-39 134.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.22 NM_009090.5_2 - 8.9e-15 53.8 0.0 1.4e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain CAMSAP_CKK PF08683.9 NM_001276359.1_3 - 7.6e-55 184.1 0.0 1.3e-54 183.4 0.0 1.4 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH PF11971.6 NM_001276359.1_3 - 1.1e-34 118.0 0.2 2.7e-34 116.7 0.2 1.7 1 0 0 1 1 1 1 CAMSAP CH domain CAMSAP_CC1 PF17095.3 NM_001276359.1_3 - 6.6e-26 89.8 3.7 6.6e-26 89.8 3.7 3.0 2 1 0 2 2 2 1 Spectrin-binding region of Ca2+-Calmodulin F420_oxidored PF03807.15 NM_001103157.2_2 - 4.2e-15 56.0 0.0 6.8e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.17 NM_001103157.2_2 - 9e-13 48.3 6.0 9e-13 48.3 6.0 2.0 1 1 1 2 2 2 1 Ferric reductase like transmembrane component 2-Hacid_dh_C PF02826.17 NM_001103157.2_2 - 0.034 13.4 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.13 NM_001103157.2_2 - 0.047 13.7 0.0 0.071 13.1 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase IQ PF00612.25 NM_029067.1_3 - 2.8e-11 42.1 18.0 0.00083 18.8 0.2 3.6 3 0 0 3 3 3 3 IQ calmodulin-binding motif zf-CCCH PF00642.22 NM_001253713.2_2 - 3.1e-06 26.8 13.5 0.0011 18.7 1.1 4.4 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 NM_001253713.2_2 - 0.00072 19.7 0.3 0.00072 19.7 0.3 3.8 4 0 0 4 4 4 1 Zinc-finger containing family zf-CCCH_2 PF14608.4 NM_001253713.2_2 - 0.43 11.0 26.1 4.5 7.8 2.2 6.0 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger zf-C3HC4 PF00097.23 NM_001034906.2_1 - 4.9e-07 29.4 8.5 4.9e-07 29.4 8.5 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001034906.2_1 - 9.9e-07 28.5 9.8 3.2e-06 26.9 4.0 3.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_001034906.2_1 - 1.4e-06 27.9 6.0 1.4e-06 27.9 6.0 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_001034906.2_1 - 3.1e-06 27.1 11.0 3.1e-06 27.1 11.0 2.4 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 NM_001034906.2_1 - 4.1e-05 23.2 8.2 4.1e-05 23.2 8.2 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 NM_001034906.2_1 - 0.00019 21.1 2.0 0.00019 21.1 2.0 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein SPRY PF00622.26 NM_001034906.2_1 - 0.00036 20.5 0.1 0.0012 18.9 0.0 1.9 2 0 0 2 2 2 1 SPRY domain zf-RING_5 PF14634.4 NM_001034906.2_1 - 0.00052 19.8 7.5 0.00052 19.8 7.5 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_001034906.2_1 - 0.00053 20.1 8.1 0.00053 20.1 8.1 3.1 3 0 0 3 3 2 1 Ring finger domain zf-B_box PF00643.22 NM_001034906.2_1 - 0.0013 18.7 12.1 0.0013 18.7 12.1 3.2 3 1 0 3 3 3 1 B-box zinc finger Prok-RING_4 PF14447.4 NM_001034906.2_1 - 0.0092 15.7 6.0 0.0092 15.7 6.0 2.9 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 UCH PF00443.27 NM_198421.1_2 - 3.9e-56 190.3 0.2 5.5e-56 189.8 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 NM_198421.1_2 - 1.3e-18 66.9 9.7 1.3e-18 66.9 9.7 3.3 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 NM_198421.1_2 - 3.8e-16 59.4 1.4 1.1e-11 44.9 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase IL1 PF00340.17 NM_019450.3_3 - 6.1e-15 54.8 0.0 1e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 V-ATPase_G PF03179.13 NM_177397.3_2 - 1.7e-33 115.1 11.4 2.3e-33 114.7 11.4 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.6 NM_177397.3_2 - 0.31 10.3 10.7 0.45 9.8 10.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF883 PF05957.11 NM_177397.3_2 - 1.3 9.5 7.5 2.5 8.6 7.1 1.6 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Muted PF14942.4 NM_177397.3_2 - 1.9 8.7 10.4 2.9 8.1 10.4 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein OmpH PF03938.12 NM_177397.3_2 - 9.7 6.0 12.9 14 5.5 12.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Syntaxin-6_N PF09177.9 NM_026412.3_3 - 8 7.0 8.1 1.6 9.2 2.8 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal GTF2I PF02946.12 NM_053266.1_2 - 1.1e-53 179.1 0.0 4.3e-28 97.0 0.0 2.5 2 0 0 2 2 2 2 GTF2I-like repeat Med25_NR-box PF11244.6 NM_053266.1_2 - 0.00037 20.7 0.0 0.00083 19.6 0.0 1.6 1 0 0 1 1 1 1 Mediator complex subunit 25 C-terminal NR box-containing DUF4371 PF14291.4 NM_053266.1_2 - 0.025 14.2 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) Trypsin PF00089.24 NM_144938.2_2 - 6.8e-57 192.7 0.0 9.8e-57 192.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 NM_144938.2_2 - 5.4e-42 142.5 0.2 7e-23 80.9 0.0 2.4 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 NM_144938.2_2 - 8.4e-14 51.8 8.3 1.7e-06 28.4 0.8 3.2 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 NM_144938.2_2 - 9.9e-09 35.2 6.0 3.7e-08 33.4 6.0 2.1 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 NM_144938.2_2 - 1.3e-05 25.2 8.2 5.7e-05 23.1 8.2 2.2 1 0 0 1 1 1 1 Calcium-binding EGF domain CUB_2 PF02408.18 NM_144938.2_2 - 0.00025 20.7 0.8 0.15 11.7 0.2 2.7 2 0 0 2 2 2 2 CUB-like domain Trypsin_2 PF13365.4 NM_144938.2_2 - 0.0037 18.0 0.0 0.0067 17.2 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain hEGF PF12661.5 NM_144938.2_2 - 0.032 14.8 3.1 0.25 12.0 3.1 2.7 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.25 NM_144938.2_2 - 0.096 12.9 8.5 0.46 10.7 8.5 2.3 1 0 0 1 1 1 0 EGF-like domain C1q PF00386.19 NM_026161.3_2 - 1.9e-71 238.0 0.0 1.4e-34 118.9 0.0 2.1 2 0 0 2 2 2 2 C1q domain RhgB_N PF09284.8 NM_026161.3_2 - 0.14 11.5 0.0 7.2 5.9 0.0 2.1 2 0 0 2 2 2 0 Rhamnogalacturonan lyase B, N-terminal PLN_propep PF16485.3 NM_011625.1_1 - 0.087 12.5 0.2 0.18 11.4 0.2 1.5 1 0 0 1 1 1 0 Protealysin propeptide Ank_2 PF12796.5 NM_011625.1_3 - 2.3e-16 60.0 0.0 4.1e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_011625.1_3 - 6.5e-14 52.0 0.2 2.9e-08 34.0 0.2 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) SH3_1 PF00018.26 NM_011625.1_3 - 3.9e-13 48.6 1.0 3.9e-13 48.6 1.0 1.9 2 0 0 2 2 2 1 SH3 domain Ank PF00023.28 NM_011625.1_3 - 5.5e-12 45.4 1.0 2.5e-05 24.4 0.2 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 NM_011625.1_3 - 5.8e-12 44.6 0.4 4e-05 23.6 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat SH3_9 PF14604.4 NM_011625.1_3 - 1.9e-10 40.3 0.2 4.7e-10 39.0 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_011625.1_3 - 1.4e-09 37.4 0.0 3.3e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Ank_5 PF13857.4 NM_011625.1_3 - 1.3e-08 34.8 0.2 3.6e-07 30.2 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Lectin_leg-like PF03388.11 NM_001310517.1_3 - 1.4e-80 269.8 0.0 2.8e-80 268.9 0.0 1.5 1 1 0 1 1 1 1 Legume-like lectin family eIF3_p135 PF12807.5 NM_001310517.1_3 - 0.043 13.7 0.6 0.07 13.0 0.6 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 PMP1_2 PF08114.9 NM_001310517.1_3 - 0.14 11.8 1.4 0.24 11.0 0.3 2.0 2 0 0 2 2 2 0 ATPase proteolipid family DUF2053 PF09767.7 NM_027215.2_1 - 9.8e-67 223.9 5.6 9.8e-67 223.9 5.6 1.9 2 0 0 2 2 2 1 Predicted membrane protein (DUF2053) zf-H2C2_2 PF13465.4 NM_001003666.2_1 - 8.9e-117 376.7 183.2 2.8e-08 33.7 3.1 20.3 20 0 0 20 20 20 20 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001003666.2_1 - 5.6e-59 193.3 158.7 0.00018 21.6 2.6 19.3 19 0 0 19 19 19 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001003666.2_1 - 1.2e-49 162.5 152.7 0.0034 18.0 0.5 19.4 19 0 0 19 19 19 18 C2H2-type zinc finger KRAB PF01352.25 NM_001003666.2_1 - 9.8e-20 69.8 0.3 1.5e-19 69.2 0.3 1.3 1 0 0 1 1 1 1 KRAB box C1_1 PF00130.20 NM_001003666.2_1 - 1.3e-13 50.5 86.4 0.028 14.2 1.0 11.3 8 4 3 11 11 11 8 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_6 PF13912.4 NM_001003666.2_1 - 3.1e-12 46.0 134.4 0.19 11.6 0.0 19.7 19 1 0 19 19 19 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001003666.2_1 - 1e-11 44.6 98.9 0.1 12.6 3.4 13.6 8 4 9 17 17 17 10 Zinc ribbon domain Zf_RING PF16744.3 NM_001003666.2_1 - 1.8e-11 43.8 80.4 1.3 9.1 0.3 17.4 3 3 13 19 19 19 7 KIAA1045 RING finger BolA PF01722.16 NM_001003666.2_1 - 1.8e-11 44.0 14.2 2 8.6 0.0 10.1 2 2 8 11 11 11 4 BolA-like protein zf-C2HC_2 PF13913.4 NM_001003666.2_1 - 6.4e-08 32.2 110.7 0.12 12.2 0.7 18.5 18 1 1 19 19 19 9 zinc-finger of a C2HC-type Desulfoferrod_N PF06397.10 NM_001003666.2_1 - 2.3e-06 27.0 107.2 1.7 8.2 0.2 17.7 18 0 0 18 18 17 9 Desulfoferrodoxin, N-terminal domain zf-C2H2_jaz PF12171.6 NM_001003666.2_1 - 1.2e-05 25.3 111.1 0.0031 17.6 0.4 18.8 19 0 0 19 19 19 3 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 NM_001003666.2_1 - 0.00027 20.8 79.7 4.3 7.3 0.2 17.8 18 0 0 18 18 18 2 XPA protein N-terminal zf-trcl PF13451.4 NM_001003666.2_1 - 0.00089 19.0 77.0 3.4 7.5 0.4 16.5 16 2 1 17 17 17 2 Probable zinc-ribbon domain zf-Sec23_Sec24 PF04810.13 NM_001003666.2_1 - 0.023 14.6 67.1 0.57 10.2 0.5 16.5 14 4 4 18 18 18 0 Sec23/Sec24 zinc finger FYVE PF01363.19 NM_001003666.2_1 - 0.027 14.5 77.3 0.84 9.7 1.3 10.7 2 2 6 8 8 8 0 FYVE zinc finger zinc_ribbon_15 PF17032.3 NM_001003666.2_1 - 0.21 12.2 72.6 0.2 12.3 1.3 9.6 6 3 3 10 10 10 0 zinc-ribbon family DUF2790 PF10976.6 NM_001003666.2_1 - 0.97 9.4 7.7 29 4.6 0.2 5.8 3 2 5 8 8 8 0 Protein of unknown function (DUF2790) zf-met PF12874.5 NM_001003666.2_1 - 2.1 8.7 109.8 0.47 10.8 0.5 18.6 19 0 0 19 19 19 0 Zinc-finger of C2H2 type DUF35_N PF12172.6 NM_001003666.2_1 - 2.2 8.1 60.5 2.9 7.7 0.2 12.6 14 0 0 14 14 14 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Ribosomal_S19 PF00203.19 NM_001003666.2_2 - 0.061 13.1 4.8 8.5 6.2 0.1 4.8 5 1 0 5 5 5 0 Ribosomal protein S19 Glyco_transf_29 PF00777.16 NM_001161774.2_1 - 6.3e-69 232.2 0.0 7.9e-69 231.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Ribosomal_L16 PF00252.16 NM_025606.3_2 - 8.4e-30 103.4 0.0 1.2e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e WH1 PF00568.21 NM_001163396.2_3 - 1.8e-34 117.9 0.4 2.8e-34 117.2 0.4 1.3 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 NM_001163396.2_3 - 2.4e-18 65.3 5.7 2.4e-18 65.3 5.7 1.8 2 0 0 2 2 2 1 VASP tetramerisation domain Ran_BP1 PF00638.16 NM_001163396.2_3 - 0.0079 16.3 0.0 0.016 15.3 0.0 1.5 1 1 0 1 1 1 1 RanBP1 domain Kelch_1 PF01344.23 NM_001163396.2_3 - 0.075 12.5 0.1 0.24 10.9 0.0 1.9 2 0 0 2 2 2 0 Kelch motif AhpC-TSA PF00578.19 NM_177256.5_2 - 5.7e-27 94.0 0.0 1e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.7 NM_177256.5_2 - 1.2e-09 37.7 0.2 2.1e-09 36.9 0.2 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.8 NM_177256.5_2 - 2.7e-06 27.0 0.0 4.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Redoxin Cast PF10174.7 NM_177814.4_2 - 0 1275.9 155.3 0 1275.7 155.3 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone IncA PF04156.12 NM_177814.4_2 - 0.0025 17.5 18.4 0.0025 17.5 18.4 8.6 2 1 7 9 9 9 3 IncA protein PKcGMP_CC PF16808.3 NM_177814.4_2 - 0.0028 17.3 0.7 0.0028 17.3 0.7 11.4 12 1 1 13 13 13 3 Coiled-coil N-terminus of cGMP-dependent protein kinase EnY2 PF10163.7 NM_175009.3_1 - 2.9e-34 117.1 0.8 3.9e-34 116.7 0.8 1.2 1 0 0 1 1 1 1 Transcription factor e(y)2 SPRY PF00622.26 NM_031172.2_2 - 1.7e-14 53.9 0.0 2.9e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-RING_UBOX PF13445.4 NM_031172.2_2 - 1.5e-13 50.4 4.5 5.7e-13 48.5 4.5 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 NM_031172.2_2 - 1.1e-12 47.8 4.9 1.1e-12 47.8 4.9 2.2 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 NM_031172.2_2 - 1e-10 41.4 2.3 1e-10 41.4 2.3 2.8 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_2 PF13923.4 NM_031172.2_2 - 2.7e-10 39.8 3.2 2.7e-10 39.8 3.2 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_031172.2_2 - 4.5e-10 39.1 6.8 4.5e-10 39.1 6.8 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_031172.2_2 - 2.6e-07 30.6 5.7 2.6e-07 30.6 5.7 2.7 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 NM_031172.2_2 - 1.6e-05 24.6 6.8 1.6e-05 24.6 6.8 2.6 2 0 0 2 2 2 1 zinc-RING finger domain PRY PF13765.4 NM_031172.2_2 - 6.8e-05 22.3 0.0 0.00023 20.6 0.0 1.9 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_3 PF13920.4 NM_031172.2_2 - 0.00031 20.4 7.8 0.00031 20.4 7.8 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 NM_031172.2_2 - 0.0038 16.9 0.6 0.0083 15.8 0.6 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Nse PF11789.6 NM_031172.2_2 - 0.004 16.8 2.2 0.0084 15.8 2.2 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.4 NM_031172.2_2 - 0.065 13.0 10.2 0.019 14.6 4.9 2.8 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 U-box PF04564.13 NM_031172.2_2 - 0.13 12.3 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 U-box domain zf-RING_11 PF17123.3 NM_031172.2_2 - 0.35 10.5 8.1 0.2 11.2 4.7 2.5 3 0 0 3 3 3 0 RING-like zinc finger zf-4CXXC_R1 PF10497.7 NM_031172.2_2 - 3.8 7.7 9.3 1 9.6 5.5 1.9 1 1 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RING_10 PF16685.3 NM_031172.2_2 - 5.9 7.0 11.2 0.73 9.9 4.9 2.6 2 1 0 2 2 2 0 zinc RING finger of MSL2 zf-rbx1 PF12678.5 NM_031172.2_2 - 9 6.5 10.3 0.56 10.4 3.1 2.6 2 0 0 2 2 2 0 RING-H2 zinc finger domain GMP_PDE_delta PF05351.9 NM_008801.2_3 - 3.8e-45 153.6 0.0 5.6e-45 153.1 0.0 1.2 1 0 0 1 1 1 1 GMP-PDE, delta subunit hSH3 PF14603.4 NM_001278269.1_3 - 3.3e-50 168.4 4.5 2.2e-42 143.3 1.0 4.9 6 0 0 6 6 6 3 Helically-extended SH3 domain SH3_2 PF07653.15 NM_001278269.1_3 - 1.3e-12 47.1 0.1 1.3e-09 37.5 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 NM_001278269.1_3 - 0.00045 19.6 0.3 0.26 10.8 0.0 2.5 2 0 0 2 2 2 2 SH3 domain DUF4651 PF15513.4 NM_001278269.1_3 - 0.014 15.0 0.1 0.13 11.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4651) UBN_AB PF14075.4 NM_001278269.1_3 - 9.9 5.7 12.9 4.3 6.9 0.4 2.4 2 0 0 2 2 2 0 Ubinuclein conserved middle domain Linker_histone PF00538.17 NM_030609.3_2 - 8.4e-22 77.2 0.7 8.4e-22 77.2 0.7 2.2 2 1 0 2 2 2 1 linker histone H1 and H5 family Ank_2 PF12796.5 NM_001039126.2_3 - 6.2e-18 65.0 0.1 2.3e-12 47.2 0.0 3.4 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 NM_001039126.2_3 - 1.8e-13 50.2 3.5 0.037 14.4 0.0 6.4 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.4 NM_001039126.2_3 - 3.6e-12 45.2 1.6 0.066 13.7 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.4 NM_001039126.2_3 - 1.9e-10 40.6 3.7 0.0027 17.9 0.0 4.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) SOCS_box PF07525.14 NM_001039126.2_3 - 1.2e-09 38.2 4.7 3.6e-09 36.7 4.7 1.9 1 0 0 1 1 1 1 SOCS box Ank_4 PF13637.4 NM_001039126.2_3 - 3.6e-07 30.5 5.1 0.0005 20.5 0.0 5.0 3 1 4 7 7 7 3 Ankyrin repeats (many copies) PI31_Prot_N PF11566.6 NM_212446.2_1 - 1.2e-26 93.3 0.0 1.9e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.9 NM_212446.2_1 - 2.4e-08 34.9 7.7 5.6e-08 33.7 7.7 1.6 1 0 0 1 1 1 1 PI31 proteasome regulator DUF4618 PF15397.4 NM_183293.1_3 - 1.6 8.0 32.5 4.5 6.5 32.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) Arc_PepC_II PF06847.9 NM_183293.1_3 - 7.3 7.1 8.6 0.25 11.7 0.7 2.6 2 1 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II 7tm_1 PF00001.19 NM_001010835.1_1 - 8.8e-57 192.2 13.8 1.1e-56 191.9 13.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001010835.1_1 - 5.9e-08 32.3 16.5 7.7e-08 31.9 16.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001010835.1_1 - 2e-05 23.9 13.2 2e-05 23.9 13.2 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 NM_001010835.1_1 - 6.7e-05 22.6 9.6 0.0005 19.7 9.6 2.1 1 1 0 1 1 1 1 Olfactory receptor Ninjurin PF04923.10 NM_001010835.1_1 - 0.064 13.1 1.6 0.29 11.0 0.5 2.3 1 1 1 2 2 2 0 Ninjurin FIIND PF13553.4 NM_001162414.1_3 - 1.5e-101 338.9 0.2 2.2e-101 338.3 0.2 1.3 1 0 0 1 1 1 1 Function to find NACHT PF05729.10 NM_001162414.1_3 - 7.1e-39 133.2 0.1 1.4e-38 132.2 0.1 1.6 1 0 0 1 1 1 1 NACHT domain CARD PF00619.19 NM_001162414.1_3 - 2.1e-20 72.4 1.0 5.2e-20 71.1 1.0 1.7 1 0 0 1 1 1 1 Caspase recruitment domain LRR_6 PF13516.4 NM_001162414.1_3 - 1.3e-06 27.9 3.3 0.00041 20.0 0.3 3.4 3 0 0 3 3 3 2 Leucine Rich repeat AAA_16 PF13191.4 NM_001162414.1_3 - 0.00015 22.1 0.1 0.00093 19.5 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.20 NM_001162414.1_3 - 0.0022 17.0 0.0 0.0053 15.7 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_30 PF13604.4 NM_001162414.1_3 - 0.015 14.9 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.4 NM_001162414.1_3 - 0.019 15.1 0.0 0.053 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sina PF03145.14 NM_001162414.1_3 - 0.037 13.9 0.4 0.082 12.7 0.4 1.5 1 0 0 1 1 1 0 Seven in absentia protein family AAA_14 PF13173.4 NM_001162414.1_3 - 0.074 13.0 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.10 NM_001162414.1_3 - 0.1 11.7 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.4 NM_001162414.1_3 - 0.11 12.6 0.1 0.56 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain LRR_4 PF12799.5 NM_001162414.1_3 - 0.79 10.1 3.7 40 4.7 0.1 3.4 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) 7tm_4 PF13853.4 NM_146367.2_2 - 5.2e-47 160.8 12.7 7.9e-47 160.2 12.7 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146367.2_2 - 5.8e-21 74.8 16.5 9.6e-21 74.1 16.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-H2C2_2 PF13465.4 NM_028319.1_3 - 0.0012 19.0 1.4 0.0012 19.0 1.4 7.2 7 0 0 7 7 7 4 Zinc-finger double domain zf-H2C2_5 PF13909.4 NM_028319.1_3 - 0.0056 16.3 0.8 0.0056 16.3 0.8 5.2 5 0 0 5 5 5 3 C2H2-type zinc-finger domain Hormone_2 PF00123.18 NM_009625.3_1 - 3.2e-23 81.2 1.0 2.8e-11 43.0 0.2 2.9 2 0 0 2 2 2 2 Peptide hormone Reprolysin PF01421.17 NM_009614.3_1 - 1.1e-52 178.7 0.0 1.8e-52 178.1 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_009614.3_1 - 1.5e-27 96.2 1.3 1.5e-27 96.2 1.3 2.5 2 0 0 2 2 2 1 ADAM cysteine-rich Disintegrin PF00200.21 NM_009614.3_1 - 1.8e-21 76.6 24.5 1.8e-21 76.6 24.5 5.1 5 0 0 5 5 5 1 Disintegrin Reprolysin_5 PF13688.4 NM_009614.3_1 - 1.3e-13 51.5 0.0 2.6e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Pep_M12B_propep PF01562.17 NM_009614.3_1 - 1.4e-12 47.9 0.0 2.7e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_3 PF13582.4 NM_009614.3_1 - 5.1e-10 39.8 0.0 8.2e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_009614.3_1 - 1.3e-07 31.5 0.0 2.2e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_009614.3_1 - 0.0001 21.9 0.0 0.00016 21.3 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like CD20 PF04103.13 NM_009614.3_1 - 0.021 14.8 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 CD20-like family Peptidase_M10 PF00413.22 NM_009614.3_1 - 0.022 14.5 0.1 0.032 14.0 0.1 1.2 1 0 0 1 1 1 0 Matrixin Myelin_MBP PF01669.15 NM_010777.3_1 - 6.6e-42 143.6 10.9 6.6e-42 143.6 10.9 2.7 2 1 1 3 3 3 2 Myelin basic protein SOCS PF12610.6 NM_019654.2_2 - 1.9e-16 60.0 3.7 6.8e-16 58.3 3.7 2.0 1 0 0 1 1 1 1 Suppressor of cytokine signalling SOCS_box PF07525.14 NM_019654.2_2 - 5.2e-09 36.2 0.0 1.3e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 SOCS box SH2 PF00017.22 NM_019654.2_2 - 3e-08 33.5 0.0 5.5e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 SH2 domain DUF3915 PF13054.4 NM_019724.4_1 - 0.85 9.5 3.4 1.5 8.7 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Peptidase_M10 PF00413.22 NM_019724.4_3 - 2.4e-59 199.6 0.0 3.5e-59 199.0 0.0 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 NM_019724.4_3 - 1.9e-55 184.4 16.8 1.5e-16 59.9 0.5 4.7 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.6 NM_019724.4_3 - 1.1e-29 102.0 0.2 2.3e-29 101.0 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.16 NM_019724.4_3 - 7.6e-09 35.5 0.1 2e-08 34.2 0.0 1.7 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Astacin PF01400.22 NM_019724.4_3 - 0.00063 19.3 0.6 0.95 8.9 0.0 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Peptidase_M66 PF10462.7 NM_019724.4_3 - 0.1 11.4 0.1 0.15 10.8 0.1 1.1 1 0 0 1 1 1 0 Peptidase M66 Metallopep PF12044.6 NM_019724.4_3 - 0.17 10.3 0.0 0.25 9.8 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase family Bombesin PF02044.15 NM_175012.4_2 - 8.8e-07 28.4 4.3 2e-06 27.3 4.3 1.6 1 0 0 1 1 1 1 Bombesin-like peptide Pkinase PF00069.23 NM_007661.3_3 - 6.3e-66 222.3 0.0 6.3e-66 222.3 0.0 1.9 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_007661.3_3 - 6.8e-31 107.4 0.2 2.3e-30 105.6 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_007661.3_3 - 0.0036 16.5 0.0 0.0036 16.5 0.0 2.6 2 1 1 3 3 3 2 Kinase-like LRR_9 PF14580.4 NM_028959.3_3 - 4e-11 42.6 0.8 1.7e-10 40.6 0.8 2.0 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 NM_028959.3_3 - 1.7e-05 24.9 2.0 5.7e-05 23.2 0.7 2.6 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_028959.3_3 - 0.00013 21.6 5.6 0.00062 19.4 2.0 2.5 1 1 1 2 2 2 2 Leucine rich repeat GOLGA2L5 PF15070.4 NM_028959.3_3 - 0.005 15.4 13.2 0.0085 14.7 13.2 1.2 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 Filament PF00038.19 NM_028959.3_3 - 0.0081 15.6 12.5 0.014 14.8 12.5 1.3 1 0 0 1 1 1 1 Intermediate filament protein FadA PF09403.8 NM_028959.3_3 - 0.036 14.4 7.0 0.065 13.6 7.0 1.4 1 0 0 1 1 1 0 Adhesion protein FadA LRR_1 PF00560.31 NM_028959.3_3 - 0.055 13.8 1.7 14 6.5 0.0 3.6 2 0 0 2 2 2 0 Leucine Rich Repeat Sec34 PF04136.13 NM_028959.3_3 - 0.11 12.3 10.9 0.31 10.8 10.9 1.8 1 0 0 1 1 1 0 Sec34-like family DUF641 PF04859.10 NM_028959.3_3 - 0.11 12.7 16.8 0.12 12.6 4.1 2.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Spc7 PF08317.9 NM_028959.3_3 - 0.19 10.5 17.0 0.3 9.8 17.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein MCPsignal PF00015.19 NM_028959.3_3 - 0.2 11.3 5.3 0.32 10.6 5.3 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Ntox28 PF15605.4 NM_028959.3_3 - 0.21 11.7 4.1 0.28 11.3 0.1 2.3 1 1 0 2 2 2 0 Bacterial toxin 28 DUF4407 PF14362.4 NM_028959.3_3 - 0.24 10.6 8.8 0.38 9.9 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Reo_sigmaC PF04582.10 NM_028959.3_3 - 0.3 10.3 7.9 0.72 9.1 7.6 1.7 1 1 0 1 1 1 0 Reovirus sigma C capsid protein DUF972 PF06156.11 NM_028959.3_3 - 0.35 11.4 20.0 0.25 11.8 5.8 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF972) HIP1_clath_bdg PF16515.3 NM_028959.3_3 - 0.49 10.9 17.2 0.21 12.1 4.8 2.7 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 COG5 PF10392.7 NM_028959.3_3 - 0.68 10.0 13.7 1.6 8.8 13.1 1.9 1 1 0 1 1 1 0 Golgi transport complex subunit 5 DUF1664 PF07889.10 NM_028959.3_3 - 0.85 9.5 13.3 1 9.2 5.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.8 NM_028959.3_3 - 1.1 9.3 9.9 1.2 9.2 8.6 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family LRR_6 PF13516.4 NM_028959.3_3 - 2.4 8.3 4.4 7.3 6.8 0.1 3.1 2 1 1 3 3 3 0 Leucine Rich repeat Dynactin_p22 PF07426.9 NM_028959.3_3 - 2.7 7.7 16.7 5 6.8 16.7 1.4 1 0 0 1 1 1 0 Dynactin subunit p22 TMF_DNA_bd PF12329.6 NM_028959.3_3 - 3.2 7.7 16.3 0.92 9.4 5.9 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding PPR_2 PF13041.4 NM_027275.3_2 - 4.2e-22 78.0 0.9 1.4e-07 31.5 0.2 5.5 5 0 0 5 5 5 3 PPR repeat family PPR_3 PF13812.4 NM_027275.3_2 - 6.2e-12 45.3 4.3 4.6e-07 29.7 0.1 4.5 2 1 3 5 5 5 3 Pentatricopeptide repeat domain PPR_long PF17177.2 NM_027275.3_2 - 3.6e-06 26.4 0.1 5.6e-05 22.5 0.0 2.4 1 1 1 2 2 2 1 Pentacotripeptide-repeat region of PROPR PPR_1 PF12854.5 NM_027275.3_2 - 1.4e-05 24.6 0.0 1.1 8.9 0.0 4.9 6 0 0 6 6 6 2 PPR repeat RPM2 PF08579.9 NM_027275.3_2 - 0.0027 17.9 0.1 0.011 15.9 0.1 2.0 2 0 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) PPR PF01535.18 NM_027275.3_2 - 3.2 8.1 13.5 1.3 9.3 0.1 6.1 9 0 0 9 9 9 0 PPR repeat Rrp15p PF07890.10 NM_026041.2_3 - 8e-32 110.1 14.0 8e-32 110.1 14.0 2.2 2 0 0 2 2 2 1 Rrp15p MctB PF11382.6 NM_026041.2_3 - 0.00066 19.3 1.7 0.00085 19.0 1.1 1.5 1 1 0 1 1 1 1 Copper transport outer membrane protein, MctB UPF0524 PF15823.3 NM_026041.2_3 - 0.41 9.9 5.3 0.63 9.3 5.3 1.3 1 0 0 1 1 1 0 UPF0524 of C3orf70 OmpH PF03938.12 NM_026041.2_3 - 2.4 8.0 12.2 0.62 9.9 7.4 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Ras PF00071.20 NM_001081105.1_1 - 6.2e-43 146.1 0.0 9.3e-43 145.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001081105.1_1 - 1.3e-21 76.9 0.0 1.9e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001081105.1_1 - 1.8e-06 27.4 0.0 2.8e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001081105.1_1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase 7tm_4 PF13853.4 NM_146936.1_1 - 9.1e-53 179.7 22.5 1.1e-52 179.3 22.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146936.1_1 - 3.7e-22 78.7 24.2 1e-21 77.3 24.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-H2C2_2 PF13465.4 NM_172738.3_3 - 8.6e-40 133.3 57.7 1.8e-08 34.3 3.2 9.2 9 0 0 9 9 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 NM_172738.3_3 - 3.7e-37 124.6 70.5 1.4e-06 28.2 1.4 10.0 11 0 0 11 11 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_172738.3_3 - 3.2e-26 89.6 69.1 0.00013 22.4 0.8 10.0 11 0 0 11 11 9 8 C2H2-type zinc finger KRAB PF01352.25 NM_172738.3_3 - 4e-17 61.5 2.2 8.1e-17 60.5 2.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_172738.3_3 - 1.9e-14 53.1 41.6 0.0029 17.4 0.3 7.9 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_172738.3_3 - 8.5e-13 47.7 42.4 0.00082 19.0 1.3 8.8 9 0 0 9 9 9 5 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 NM_172738.3_3 - 8e-09 35.5 38.2 0.084 13.1 0.3 8.7 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.3 NM_172738.3_3 - 6.1e-05 23.1 30.5 0.1 12.8 3.0 4.4 1 1 3 4 4 4 4 C2H2-type zinc ribbon zf-C2HE PF16278.3 NM_172738.3_3 - 9.6e-05 22.6 36.7 0.23 11.8 1.5 7.3 2 2 5 7 7 7 2 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.5 NM_172738.3_3 - 0.0029 17.8 50.8 2.9 8.3 0.9 9.3 9 0 0 9 9 9 4 Zinc-finger of C2H2 type zf-AN1 PF01428.14 NM_172738.3_3 - 0.0066 16.5 41.9 0.73 9.9 1.2 8.3 7 1 1 8 8 8 3 AN1-like Zinc finger zinc_ribbon_15 PF17032.3 NM_172738.3_3 - 0.021 15.4 30.2 0.4 11.3 0.6 4.7 2 1 3 5 5 4 0 zinc-ribbon family Zn-ribbon_8 PF09723.8 NM_172738.3_3 - 0.024 14.6 36.7 0.12 12.4 3.8 6.5 2 2 5 7 7 7 0 Zinc ribbon domain HypA PF01155.17 NM_172738.3_3 - 0.12 12.3 26.5 0.48 10.3 0.4 5.1 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_1 PF00130.20 NM_172738.3_3 - 0.44 10.4 34.4 0.24 11.2 1.0 6.3 2 1 5 7 7 7 0 Phorbol esters/diacylglycerol binding domain (C1 domain) YhfH PF14149.4 NM_172738.3_3 - 0.75 9.7 26.6 5.1 7.0 0.3 7.3 7 0 0 7 7 7 0 YhfH-like protein Zn_Tnp_IS1595 PF12760.5 NM_172738.3_3 - 2 8.3 36.6 0.4 10.6 1.6 5.7 1 1 6 7 7 7 0 Transposase zinc-ribbon domain zf-3CxxC PF13695.4 NM_172738.3_3 - 8.4 6.8 30.2 3.1 8.2 0.4 5.2 3 1 2 5 5 4 0 Zinc-binding domain 7tm_3 PF00003.20 NM_001104578.1_1 - 8.3e-61 205.6 32.8 8.3e-61 205.6 32.8 2.0 2 1 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001104578.1_1 - 1.7e-29 102.9 2.8 2.6e-29 102.3 2.8 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001104578.1_1 - 4.5e-18 64.8 9.2 1e-17 63.7 9.2 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Rad10 PF03834.12 NM_001104578.1_1 - 0.056 13.3 0.3 0.29 11.0 0.2 2.3 1 1 1 2 2 2 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Ephrin_rec_like PF07699.11 NM_001104578.1_1 - 2.1 8.0 7.7 18 5.1 7.9 2.3 1 1 0 1 1 1 0 Putative ephrin-receptor like ubiquitin PF00240.21 NM_001166062.2_1 - 4.5e-05 23.0 0.2 0.00016 21.2 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.4 NM_001166062.2_1 - 0.0012 19.2 0.2 0.0048 17.2 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Palm_thioest PF02089.13 NM_001302393.1_3 - 3.9e-15 55.6 0.0 5.5e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.18 NM_001302393.1_3 - 3.3e-06 26.8 0.1 1.2e-05 24.9 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF676 PF05057.12 NM_001302393.1_3 - 0.0014 18.0 0.0 0.0045 16.4 0.0 1.7 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.11 NM_001302393.1_3 - 0.0063 16.1 0.0 0.021 14.4 0.0 1.7 1 1 0 2 2 2 1 PGAP1-like protein Lipase_2 PF01674.16 NM_001302393.1_3 - 0.03 13.7 0.0 0.35 10.2 0.0 2.1 1 1 0 1 1 1 0 Lipase (class 2) Cbl_N3 PF02762.12 NM_001161844.1_1 - 1.2e-41 140.3 0.0 2.1e-41 139.5 0.0 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N PF02262.14 NM_001161844.1_1 - 2.2e-41 140.7 0.0 3.5e-41 140.0 0.0 1.3 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N2 PF02761.12 NM_001161844.1_1 - 1.4e-32 112.1 0.0 2.2e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Sin_N PF04801.11 NM_025298.3_1 - 2.2e-157 524.5 5.4 6.5e-157 523.0 2.6 2.2 2 0 0 2 2 2 1 Sin-like protein conserved region zf-TFIIB PF13453.4 NM_025298.3_1 - 0.027 13.6 2.2 0.15 11.3 2.2 2.4 1 0 0 1 1 1 0 Transcription factor zinc-finger DEAD PF00270.27 NM_001145885.1_3 - 4.8e-49 166.4 0.0 1e-48 165.3 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001145885.1_3 - 2.4e-30 105.0 0.3 7.3e-30 103.5 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_001145885.1_3 - 0.011 15.7 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NCD1 PF04904.11 NM_001177399.1_1 - 0.01 15.7 0.4 2.4 8.1 0.0 3.0 3 0 0 3 3 3 0 NAB conserved region 1 (NCD1) DUF3505 PF12013.6 NM_001177399.1_1 - 0.017 15.4 16.6 1.8 8.9 0.2 5.4 2 1 5 7 7 7 0 Protein of unknown function (DUF3505) DUF5132 PF17195.2 NM_001177399.1_1 - 0.056 13.4 1.0 43 4.2 0.0 5.5 8 0 0 8 8 8 0 Protein of unknown function (DUF5132) zf-H2C2_2 PF13465.4 NM_001177399.1_1 - 0.12 12.7 0.6 0.72 10.3 0.6 2.5 1 0 0 1 1 1 0 Zinc-finger double domain zf-Di19 PF05605.10 NM_001177399.1_1 - 4.2 7.6 10.8 41 4.4 0.0 5.1 2 1 5 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding RFC1 PF08519.10 NM_001177399.1_1 - 4.2 7.4 14.5 8.1 6.5 0.4 4.4 3 1 2 5 5 5 0 Replication factor RFC1 C terminal domain zf-H2C2_2 PF13465.4 NM_001177399.1_3 - 9.3e-115 370.3 137.5 1.2e-09 38.0 1.6 18.1 18 0 0 18 18 18 16 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001177399.1_3 - 3.2e-59 194.1 125.7 5e-06 26.6 0.7 16.0 16 0 0 16 16 16 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001177399.1_3 - 3e-40 133.3 118.4 0.00017 22.0 0.9 16.0 15 0 0 15 15 15 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001177399.1_3 - 2e-23 81.7 117.4 8.6e-05 22.3 1.2 15.8 15 1 0 15 15 15 12 C2H2-type zinc finger KRAB PF01352.25 NM_001177399.1_3 - 3.3e-19 68.2 0.1 5.8e-19 67.4 0.1 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_001177399.1_3 - 7e-08 32.3 78.4 0.17 11.9 5.0 9.5 2 2 10 12 12 12 12 Zinc ribbon domain XPA_N PF01286.16 NM_001177399.1_3 - 8.3e-07 28.8 63.8 6.5 6.8 0.1 13.6 14 0 0 14 14 13 8 XPA protein N-terminal C1_4 PF07975.10 NM_001177399.1_3 - 2.3e-06 27.6 67.3 0.16 12.1 4.2 10.4 1 1 9 11 11 11 7 TFIIH C1-like domain zf-C2H2_jaz PF12171.6 NM_001177399.1_3 - 0.0029 17.8 5.3 0.01 16.0 0.7 13.5 15 0 0 15 15 15 6 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_001177399.1_3 - 0.03 14.5 61.0 0.061 13.5 1.2 8.0 1 1 7 11 11 11 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 NM_001177399.1_3 - 0.084 13.5 71.7 0.22 12.1 3.0 7.5 1 1 12 13 13 13 0 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_001177399.1_3 - 0.098 12.3 73.3 0.3 10.8 0.1 12.9 13 0 0 13 13 13 0 zinc-finger C2H2-type FYVE PF01363.19 NM_001177399.1_3 - 1 9.4 79.1 0.66 10.0 5.8 8.2 1 1 6 7 7 6 0 FYVE zinc finger zf-H2C2_2 PF13465.4 NM_177226.5_3 - 4.3e-104 336.6 140.9 1.1e-08 35.0 1.2 22.5 23 0 0 23 23 22 15 Zinc-finger double domain zf-C2H2 PF00096.24 NM_177226.5_3 - 5.8e-96 309.8 129.1 2.8e-07 30.5 0.7 19.6 19 0 0 19 19 19 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_177226.5_3 - 1e-58 190.7 127.1 0.00015 22.1 0.6 19.9 19 0 0 19 19 19 18 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_177226.5_3 - 1.4e-20 72.6 111.6 0.00032 20.4 0.1 19.3 19 0 0 19 19 19 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_177226.5_3 - 2.3e-19 69.0 76.3 0.23 11.7 0.0 18.3 19 0 0 19 19 19 9 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_177226.5_3 - 6.7e-12 45.2 81.9 0.026 14.5 2.4 13.6 7 2 8 17 17 17 9 Zinc ribbon domain ADK_lid PF05191.12 NM_177226.5_3 - 1.4e-05 24.9 42.2 0.6 10.1 0.3 11.3 8 2 2 10 10 10 2 Adenylate kinase, active site lid zf-Di19 PF05605.10 NM_177226.5_3 - 0.00028 20.9 0.9 0.00028 20.9 0.9 11.5 6 1 8 15 15 15 5 Drought induced 19 protein (Di19), zinc-binding FYDLN_acid PF09538.8 NM_177226.5_3 - 0.00047 20.7 46.6 8.5 7.0 0.0 13.5 6 1 8 15 15 13 3 Protein of unknown function (FYDLN_acid) TF_Zn_Ribbon PF08271.10 NM_177226.5_3 - 0.0012 18.2 0.7 0.0012 18.2 0.7 12.1 13 3 0 13 13 13 4 TFIIB zinc-binding C1_4 PF07975.10 NM_177226.5_3 - 0.0032 17.6 55.8 2.1 8.5 0.3 10.6 7 1 8 15 15 14 4 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 NM_177226.5_3 - 0.0071 16.9 57.8 0.49 11.1 0.8 9.3 4 1 10 14 14 13 6 zinc-ribbon family DZR PF12773.5 NM_177226.5_3 - 0.011 15.6 75.9 1.6e+04 -6.6 11.6 11.0 2 2 0 2 2 0 0 Double zinc ribbon CpXC PF14353.4 NM_177226.5_3 - 0.17 11.8 58.7 1.7 8.6 0.5 14.1 9 5 2 13 13 13 0 CpXC protein XPA_N PF01286.16 NM_177226.5_3 - 0.57 10.1 82.9 3.3 7.7 0.2 17.8 19 0 0 19 19 19 0 XPA protein N-terminal DUF329 PF03884.12 NM_177226.5_3 - 1.6 8.4 20.4 42 3.9 0.5 7.5 7 0 0 7 7 6 0 Domain of unknown function (DUF329) GAGA PF09237.9 NM_177226.5_3 - 2 8.2 24.7 5.2 6.8 0.3 7.2 4 2 3 7 7 7 0 GAGA factor DUF3268 PF11672.6 NM_177226.5_3 - 5.1 7.3 47.5 0.93 9.7 0.1 8.0 6 2 1 10 10 7 0 zinc-finger-containing domain Calcipressin PF04847.10 NM_019466.4_1 - 1.1e-60 204.5 0.9 1.5e-60 204.0 0.9 1.2 1 0 0 1 1 1 1 Calcipressin ThiF PF00899.19 NM_172712.2_3 - 7.9e-91 303.6 0.0 6.8e-62 208.9 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.7 NM_172712.2_3 - 4.5e-79 265.8 2.4 7.2e-79 265.1 2.4 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.3 NM_172712.2_3 - 1.3e-25 89.2 0.0 2.8e-25 88.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.3 NM_172712.2_3 - 1.2e-17 63.7 0.6 3.1e-17 62.4 0.6 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_UFD PF09358.8 NM_172712.2_3 - 6.2e-16 58.8 0.0 5.4e-15 55.8 0.0 2.6 3 0 0 3 3 3 1 Ubiquitin fold domain Troponin PF00992.18 NM_001163668.1_2 - 2.4e-33 115.2 34.7 2.4e-33 115.2 34.7 3.2 2 1 1 3 3 3 2 Troponin CHGN PF05679.14 NM_133913.2_2 - 8.7e-145 483.3 0.0 1e-144 483.1 0.0 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.14 NM_133913.2_2 - 1.4e-08 34.4 0.0 2.4e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Fringe-like Filament PF00038.19 NM_001291061.1_3 - 4.9e-14 52.5 36.0 3.2e-11 43.3 11.9 2.2 2 0 0 2 2 2 2 Intermediate filament protein DUF1664 PF07889.10 NM_001291061.1_3 - 0.021 14.6 2.2 0.11 12.3 2.2 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Spc7 PF08317.9 NM_001291061.1_3 - 0.2 10.3 32.5 0.0066 15.2 14.3 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF247 PF03140.13 NM_001291061.1_3 - 0.41 9.8 6.0 1.2 8.3 6.0 1.5 1 1 0 1 1 1 0 Plant protein of unknown function Baculo_PEP_C PF04513.10 NM_001291061.1_3 - 0.46 10.4 8.8 0.026 14.4 1.3 2.6 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5082 PF16888.3 NM_001291061.1_3 - 1.1 9.5 11.9 0.57 10.4 7.9 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) AAA_13 PF13166.4 NM_001291061.1_3 - 1.5 7.2 17.1 2.6 6.5 17.1 1.3 1 0 0 1 1 1 0 AAA domain LemA PF04011.10 NM_001291061.1_3 - 2.1 7.6 12.3 0.059 12.7 3.3 2.3 1 1 1 2 2 2 0 LemA family Homeobox_KN PF05920.9 NM_001301137.1_3 - 1.2e-15 57.0 0.4 2.7e-15 55.8 0.4 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 NM_001301137.1_3 - 3.6e-07 29.8 0.6 6.3e-07 29.0 0.6 1.4 1 0 0 1 1 1 1 Homeobox domain ADAM_CR PF08516.10 NM_027665.2_1 - 2.6e-30 105.0 3.5 2.6e-30 105.0 3.5 3.9 3 2 0 3 3 3 1 ADAM cysteine-rich Reprolysin PF01421.17 NM_027665.2_1 - 7.2e-30 104.3 0.0 1.8e-29 103.0 0.0 1.7 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 NM_027665.2_1 - 3.2e-20 72.7 0.0 6.2e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 NM_027665.2_1 - 1.7e-18 67.1 28.6 1.7e-18 67.1 28.6 4.1 5 1 0 5 5 5 1 Disintegrin Reprolysin_5 PF13688.4 NM_027665.2_1 - 6e-06 26.4 0.1 4.2e-05 23.7 0.0 2.1 1 1 1 2 2 2 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 NM_027665.2_1 - 0.014 15.8 0.1 0.052 13.9 0.0 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Caldesmon PF02029.13 NM_001271508.1_2 - 4.4e-26 91.6 27.9 1.2e-24 86.9 3.6 3.2 3 0 0 3 3 3 2 Caldesmon Myb_DNA-bind_4 PF13837.4 NM_001085538.2_1 - 2.1e-05 24.7 0.5 0.0069 16.6 0.3 2.3 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain MFS_1 PF07690.14 NM_144836.2_3 - 3.1e-42 144.6 37.0 4.5e-42 144.1 37.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Trypsin PF00089.24 NM_001302485.1_2 - 1.3e-61 208.1 0.0 1.5e-61 207.9 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_001302485.1_2 - 6.1e-08 33.5 0.0 9.6e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_001302485.1_2 - 0.00013 22.2 0.0 0.0003 21.0 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Peptidase_S29 PF02907.13 NM_001302485.1_2 - 0.034 13.7 0.1 0.059 13.0 0.1 1.3 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease PTB PF08416.11 NM_153533.2_1 - 2.5e-39 134.3 0.0 4.2e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PTEN_C2 PF10409.7 NM_153533.2_1 - 2.4e-25 88.7 0.0 3.5e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein SH2 PF00017.22 NM_153533.2_1 - 1.1e-09 38.1 0.0 1.9e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 SH2 domain C1_1 PF00130.20 NM_153533.2_1 - 5.6e-06 26.0 5.5 1.4e-05 24.8 5.5 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.3 NM_153533.2_1 - 0.017 15.1 5.3 0.032 14.2 3.2 2.2 2 0 0 2 2 2 0 KIAA1045 RING finger Zn_ribbon_17 PF17120.3 NM_153533.2_1 - 0.062 12.8 6.1 0.17 11.4 6.1 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type C1_2 PF03107.14 NM_153533.2_1 - 3.1 8.0 9.6 0.06 13.5 1.3 2.5 3 0 0 3 3 3 0 C1 domain PHD PF00628.27 NM_153533.2_1 - 5.1 6.9 10.0 0.68 9.7 5.1 2.2 2 0 0 2 2 2 0 PHD-finger Homeobox PF00046.27 NM_008584.3_1 - 2.7e-22 78.2 7.5 5.9e-22 77.1 7.5 1.6 1 0 0 1 1 1 1 Homeobox domain SelP_N PF04592.12 NM_008584.3_1 - 0.74 9.0 17.7 1.5 8.0 17.7 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF2475 PF10629.7 NM_026624.3_3 - 5.5e-23 80.8 4.2 7.7e-13 48.3 0.6 3.4 3 0 0 3 3 3 3 Protein of unknown function (DUF2475) OB_NTP_bind PF07717.14 NM_026624.3_3 - 0.0061 16.5 0.0 4.1 7.4 0.0 2.3 2 0 0 2 2 2 2 Oligonucleotide/oligosaccharide-binding (OB)-fold RINGv PF12906.5 NM_175188.4_1 - 2.9e-15 56.0 16.4 6.8e-15 54.8 16.4 1.7 1 0 0 1 1 1 1 RING-variant domain Hist_deacetyl PF00850.17 NM_008229.2_2 - 2e-83 280.3 0.1 2.8e-83 279.8 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Glycos_transf_2 PF00535.24 NM_027864.2_3 - 1e-27 96.9 0.0 1.8e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 NM_027864.2_3 - 1.4e-22 80.2 2.2 2.4e-22 79.4 2.2 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.4 NM_027864.2_3 - 1.3e-07 31.6 0.0 2.2e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.7 NM_027864.2_3 - 6e-06 25.8 0.0 1.2e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.12 NM_027864.2_3 - 0.011 15.2 0.1 0.021 14.3 0.1 1.4 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase DUF4519 PF15012.4 NM_027864.2_3 - 0.19 11.8 0.0 0.19 11.8 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) KRTAP PF11759.6 NM_028621.3_2 - 0.0001 22.6 165.9 0.0047 17.3 87.8 3.3 1 1 1 2 2 2 1 Keratin-associated matrix DUF4929 PF16283.3 NM_028621.3_3 - 7.3 5.3 8.4 1.1 8.1 1.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4929) N_BRCA1_IG PF16158.3 NM_001252220.1_3 - 1.8e-30 105.6 0.4 3.7e-30 104.5 0.4 1.6 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.22 NM_001252220.1_3 - 8.8e-13 47.8 0.0 1.6e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 PB1 domain ZZ PF00569.15 NM_001252220.1_3 - 5.7e-05 22.7 6.9 0.00013 21.5 6.9 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.14 NM_001252220.1_3 - 0.1 12.8 5.3 0.26 11.5 5.3 1.7 1 0 0 1 1 1 0 C1 domain NHL PF01436.19 NM_172501.2_2 - 1.8e-09 37.0 5.4 1.8e-06 27.6 0.1 5.1 6 0 0 6 6 6 1 NHL repeat SGL PF08450.10 NM_172501.2_2 - 7.2e-06 25.6 0.1 0.0065 16.0 0.1 3.3 1 1 1 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region Lactonase PF10282.7 NM_172501.2_2 - 0.061 12.4 0.0 1.5 7.8 0.0 2.1 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller Tachylectin PF14517.4 NM_172501.2_2 - 0.081 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Tachylectin DENN PF02141.19 NM_001166501.1_2 - 4.2e-48 163.6 3.6 7.2e-48 162.9 3.6 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 NM_001166501.1_2 - 1.2e-12 48.3 0.6 4e-12 46.6 0.6 2.0 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 NM_001166501.1_2 - 4.9e-09 35.9 0.9 9.2e-09 35.0 0.9 1.5 1 0 0 1 1 1 1 dDENN domain C2 PF00168.28 NM_001285858.1_2 - 2.2e-31 108.0 0.0 1.7e-17 63.5 0.0 2.2 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.22 NM_001285858.1_2 - 0.0016 18.4 0.0 0.89 9.5 0.0 2.2 2 0 0 2 2 2 2 Phosphoinositide 3-kinase C2 UPF0560 PF10577.7 NM_001285858.1_2 - 0.014 13.8 0.2 0.019 13.4 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 EphA2_TM PF14575.4 NM_001285858.1_2 - 0.014 16.0 0.0 0.031 14.9 0.0 1.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain 7tm_4 PF13853.4 NM_146596.1_1 - 4.9e-47 160.9 13.4 6.3e-47 160.5 13.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146596.1_1 - 2.5e-27 95.6 13.6 4.9e-27 94.7 13.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146596.1_1 - 1.3e-07 31.2 11.0 1.7e-07 30.8 11.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_146596.1_1 - 0.11 11.7 6.1 0.2 10.8 6.1 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx V1R PF03402.12 NM_053219.2_1 - 1.3e-124 415.0 31.6 1.6e-124 414.7 31.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R DNA_methylase PF00145.15 NM_010066.4_1 - 1e-47 163.0 1.6 6e-47 160.5 0.0 2.8 2 2 0 2 2 2 1 C-5 cytosine-specific DNA methylase DNMT1-RFD PF12047.6 NM_010066.4_1 - 2.5e-45 153.9 0.0 1.5e-44 151.4 0.0 2.2 2 0 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain BAH PF01426.16 NM_010066.4_1 - 6.6e-43 145.3 0.3 9.6e-21 73.7 0.1 3.0 3 0 0 3 3 3 2 BAH domain DMAP_binding PF06464.9 NM_010066.4_1 - 8e-20 71.6 2.1 8e-20 71.6 2.1 3.0 3 1 0 3 3 3 1 DMAP1-binding Domain zf-CXXC PF02008.18 NM_010066.4_1 - 1.7e-14 53.4 21.1 1.7e-14 53.4 21.1 2.3 2 0 0 2 2 2 1 CXXC zinc finger domain HTH_12 PF08461.8 NM_010066.4_1 - 0.14 12.0 2.9 0.076 12.8 0.2 1.9 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain ANF_receptor PF01094.26 NM_001081097.2_1 - 1e-71 241.8 0.0 1.3e-71 241.4 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 NM_001081097.2_1 - 1.7e-52 177.1 0.1 3e-52 176.3 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_001081097.2_1 - 1.1e-45 154.4 0.0 2.3e-45 153.4 0.0 1.6 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_001081097.2_1 - 5e-18 65.2 0.0 8.5e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 NM_001081097.2_1 - 5.4e-06 26.2 0.0 8.4e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein EF-hand_7 PF13499.4 NM_001199242.1_3 - 2.4e-23 82.3 2.7 4.7e-17 62.1 0.3 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_001199242.1_3 - 8.7e-20 68.6 9.2 2e-07 30.0 0.2 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_001199242.1_3 - 4.4e-17 60.4 7.1 3.4e-05 23.3 0.1 4.0 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.4 NM_001199242.1_3 - 2.2e-15 55.3 4.0 9.3e-05 21.7 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 NM_001199242.1_3 - 1.1e-12 47.4 6.5 7.2e-06 25.5 0.2 3.6 1 1 2 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_001199242.1_3 - 1.4e-06 28.4 1.5 0.00012 22.2 0.5 3.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_001199242.1_3 - 0.014 15.2 1.0 0.053 13.3 0.1 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.4 NM_001199242.1_3 - 0.043 14.0 0.3 4.5 7.5 0.0 3.3 1 1 1 2 2 2 0 EF-hand domain Caleosin PF05042.11 NM_001199242.1_3 - 1.1 9.1 5.9 21 4.8 0.1 3.2 2 1 1 3 3 3 0 Caleosin related protein SCAN PF02023.15 NM_030713.2_1 - 3.3e-41 138.9 2.8 7e-41 137.8 2.8 1.6 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 NM_030713.2_1 - 1.7e-34 116.2 80.5 1.1e-05 25.5 3.1 9.0 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_030713.2_1 - 2.7e-33 112.8 81.1 1.7e-08 34.4 2.4 10.7 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_030713.2_1 - 9.5e-18 63.2 78.7 0.011 16.4 4.2 9.2 9 0 0 9 9 8 8 C2H2-type zinc finger KRAB PF01352.25 NM_030713.2_1 - 7.2e-12 44.7 0.1 1.4e-11 43.7 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_030713.2_1 - 2.1e-07 30.9 40.8 0.11 12.7 0.2 8.8 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_030713.2_1 - 0.0023 18.1 57.1 0.23 11.8 5.0 7.4 8 0 0 8 8 7 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 NM_030713.2_1 - 0.011 15.6 62.4 0.038 13.8 1.3 9.0 9 0 0 9 9 9 0 C2H2-type zinc finger ADK_lid PF05191.12 NM_030713.2_1 - 0.027 14.4 0.3 0.027 14.4 0.3 5.3 4 1 2 6 6 6 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 NM_030713.2_1 - 0.13 12.2 32.6 0.88 9.6 2.1 5.1 4 1 1 5 5 5 0 Zinc ribbon domain DZR PF12773.5 NM_030713.2_1 - 0.32 10.9 32.6 7.5 6.5 1.9 5.0 2 1 0 2 2 1 0 Double zinc ribbon zinc_ribbon_15 PF17032.3 NM_030713.2_1 - 0.96 10.1 27.2 0.2 12.3 2.3 4.5 1 1 1 4 4 4 0 zinc-ribbon family zf-trcl PF13451.4 NM_030713.2_1 - 1.4 8.7 27.5 0.15 11.8 0.2 5.9 5 1 1 6 6 6 0 Probable zinc-ribbon domain Chordopox_RPO7 PF05864.10 NM_030713.2_1 - 3.4 7.9 7.2 8 6.7 0.4 3.3 3 1 1 4 4 3 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) YhfH PF14149.4 NM_030713.2_1 - 9 6.2 20.1 3.6 7.5 0.1 6.0 6 0 0 6 6 6 0 YhfH-like protein Tetraspannin PF00335.18 NM_133655.2_3 - 2.9e-47 161.1 13.5 2.9e-47 161.1 13.5 1.4 2 0 0 2 2 2 1 Tetraspanin family Smac_DIABLO PF09057.8 NM_023232.3_3 - 1.5e-101 338.4 10.4 1.9e-101 338.0 10.4 1.1 1 0 0 1 1 1 1 Second Mitochondria-derived Activator of Caspases Myosin_head PF00063.19 NM_001039546.2_3 - 1.3e-239 796.8 4.5 1.3e-239 796.8 4.5 1.5 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin-VI_CBD PF16521.3 NM_001039546.2_3 - 1.3e-43 146.8 0.3 7.8e-43 144.4 0.0 2.5 3 0 0 3 3 3 1 Myosin VI cargo binding domain Myosin_N PF02736.17 NM_001039546.2_3 - 0.0015 18.2 0.0 0.0029 17.2 0.0 1.5 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain BUD22 PF09073.8 NM_001039546.2_3 - 0.0018 17.6 25.8 0.0027 17.0 25.8 1.2 1 0 0 1 1 1 1 BUD22 IQ PF00612.25 NM_001039546.2_3 - 0.013 15.1 1.2 0.038 13.6 1.2 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif RNase_H2-Ydr279 PF09468.8 NM_001039546.2_3 - 0.25 10.7 10.0 0.58 9.5 10.0 1.7 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) AAA_16 PF13191.4 NM_001039546.2_3 - 0.88 9.8 0.0 0.88 9.8 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain PseudoU_synth_2 PF00849.20 NM_001039546.2_3 - 1.9 8.5 5.7 5.2 7.0 5.7 1.7 1 0 0 1 1 1 0 RNA pseudouridylate synthase Macoilin PF09726.7 NM_001039546.2_3 - 9.5 4.5 35.4 15 3.8 35.4 1.2 1 0 0 1 1 1 0 Transmembrane protein ApoO PF09769.7 NM_001199339.1_3 - 1e-38 132.1 0.0 1.5e-38 131.6 0.0 1.2 1 0 0 1 1 1 1 Apolipoprotein O LIM PF00412.20 NM_001142335.1_1 - 7.8e-27 93.1 20.7 8.5e-15 54.6 9.0 2.3 2 0 0 2 2 2 2 LIM domain CAP_N PF01213.17 NM_001142335.1_1 - 2.5 7.4 6.1 3.5 6.9 6.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Myosin_head PF00063.19 NM_177376.4_3 - 3e-203 676.7 0.5 3.6e-203 676.4 0.5 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Pkinase PF00069.23 NM_177376.4_3 - 1.5e-58 198.1 0.0 2.3e-58 197.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_177376.4_3 - 1.6e-40 138.9 0.0 2.4e-40 138.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase IQ PF00612.25 NM_177376.4_3 - 3.4e-06 26.2 3.2 5.7e-05 22.4 0.1 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif APH PF01636.21 NM_177376.4_3 - 0.00036 20.4 0.0 0.9 9.3 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_177376.4_3 - 0.00072 18.8 0.0 0.0014 17.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like AAA_22 PF13401.4 NM_177376.4_3 - 0.03 14.5 0.0 0.066 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 NM_177376.4_3 - 0.07 13.4 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain SKI PF01202.20 NM_198004.3_3 - 4.2e-11 43.1 0.0 7.8e-11 42.2 0.0 1.4 1 1 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.4 NM_198004.3_3 - 0.00074 19.6 0.0 0.001 19.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 NM_198004.3_3 - 0.0015 18.9 0.0 0.0039 17.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.16 NM_198004.3_3 - 0.0054 16.4 0.0 0.0081 15.8 0.0 1.2 1 0 0 1 1 1 1 Cytidylate kinase APS_kinase PF01583.18 NM_198004.3_3 - 0.0079 16.0 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase Cytidylate_kin2 PF13189.4 NM_198004.3_3 - 0.034 14.2 0.0 0.055 13.5 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase-like family AAA_16 PF13191.4 NM_198004.3_3 - 0.051 13.8 0.0 0.077 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.4 NM_198004.3_3 - 0.053 13.1 0.5 0.1 12.2 0.5 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.4 NM_198004.3_3 - 0.06 13.5 0.0 0.099 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain dNK PF01712.17 NM_198004.3_3 - 0.13 12.0 0.0 0.28 10.9 0.0 1.5 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_17 PF13207.4 NM_198004.3_3 - 0.17 12.2 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain G6PD_C PF02781.14 NM_008062.2_3 - 6.2e-117 389.8 0.0 1.7e-116 388.3 0.0 1.6 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.20 NM_008062.2_3 - 8.9e-61 205.5 0.0 1.5e-60 204.8 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain BCL_N PF04714.11 NM_009746.2_3 - 5.7e-27 93.4 7.7 1e-26 92.6 7.7 1.4 1 0 0 1 1 1 1 BCL7, N-terminal conserver region zf-H2C2_2 PF13465.4 NM_001289836.1_3 - 4.9e-68 222.6 145.6 3.7e-08 33.3 0.2 21.0 20 1 1 21 21 21 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001289836.1_3 - 1.3e-60 198.5 147.0 1.2e-05 25.4 1.5 18.4 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001289836.1_3 - 1.5e-23 81.3 156.4 0.012 16.2 2.4 18.8 19 0 0 19 19 19 13 C2H2-type zinc finger KRAB PF01352.25 NM_001289836.1_3 - 5e-06 26.0 3.7 1e-05 25.0 3.7 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001289836.1_3 - 0.0064 16.3 115.1 0.32 10.9 2.9 17.4 17 2 0 17 17 17 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001289836.1_3 - 0.3 11.1 96.6 0.013 15.4 3.2 12.7 6 3 8 15 15 15 0 Zinc ribbon domain BHD_1 PF10403.7 NM_001289836.1_3 - 0.91 9.3 3.3 60 3.5 0.0 4.9 4 1 0 4 4 4 0 Rad4 beta-hairpin domain 1 BolA PF01722.16 NM_001289836.1_3 - 1.3 9.2 30.8 0.21 11.8 0.4 6.4 6 1 0 6 6 6 0 BolA-like protein adh_short_C2 PF13561.4 NM_026172.3_1 - 1.2e-44 152.5 0.0 1.7e-44 152.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 NM_026172.3_1 - 2e-31 108.9 0.3 2.8e-31 108.4 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 NM_026172.3_1 - 6.6e-07 29.3 0.1 1e-06 28.6 0.1 1.2 1 0 0 1 1 1 1 KR domain SR-25 PF10500.7 NM_026172.3_1 - 0.21 11.0 42.6 5.2 6.5 41.3 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RNA_pol_Rpc4 PF05132.12 NM_026172.3_2 - 1.7 8.9 12.1 2.6 8.4 12.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 AA_permease_2 PF13520.4 NM_001199016.1_1 - 1.5e-63 215.0 48.9 2.2e-63 214.4 48.9 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 NM_001199016.1_1 - 4.6e-22 78.1 46.0 7.1e-22 77.5 46.0 1.2 1 0 0 1 1 1 1 Amino acid permease PDEase_I PF00233.17 NM_018779.1_1 - 2e-64 217.5 1.0 2.4e-60 204.1 0.0 2.2 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase DUF3915 PF13054.4 NM_018779.1_2 - 4.7 7.1 8.6 14 5.6 8.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) zf-H2C2_2 PF13465.4 NM_013844.2_3 - 5.1e-59 194.1 94.3 6.2e-08 32.6 0.5 12.2 11 1 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_013844.2_3 - 6e-34 114.5 101.5 2.4e-06 27.5 0.5 12.5 13 0 0 13 13 13 9 Zinc finger, C2H2 type KRAB PF01352.25 NM_013844.2_3 - 2.9e-21 74.7 1.2 7.9e-21 73.3 1.2 1.8 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_013844.2_3 - 2.3e-17 62.0 88.2 0.014 16.1 6.3 11.1 10 0 0 10 10 10 9 C2H2-type zinc finger BolA PF01722.16 NM_013844.2_3 - 0.48 10.6 16.5 2.3 8.4 0.4 5.4 4 2 1 5 5 5 0 BolA-like protein RecU PF03838.12 NM_013844.2_3 - 5.2 6.9 9.9 0.91 9.4 3.5 2.7 3 0 0 3 3 3 0 Recombination protein U MOZ_SAS PF01853.16 NM_001195004.1_3 - 2.5e-85 284.5 1.4 3.7e-85 284.0 1.4 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-C2HC PF01530.16 NM_001195004.1_3 - 2.4e-13 49.9 5.9 2.4e-13 49.9 5.9 2.6 2 0 0 2 2 2 1 Zinc finger, C2HC type Acetyltransf_7 PF13508.5 NM_001195004.1_3 - 0.13 12.6 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Guanylate_kin PF00625.19 NM_007864.3_1 - 4.2e-68 228.5 0.1 6e-68 228.0 0.1 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 NM_007864.3_1 - 3.4e-66 219.5 10.1 1.8e-21 76.1 0.1 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_assoc PF10600.7 NM_007864.3_1 - 2.7e-27 95.3 6.5 7.5e-27 93.8 6.5 1.9 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 NM_007864.3_1 - 1.8e-18 66.5 1.8 1.1e-06 28.7 0.0 3.4 3 0 0 3 3 3 3 PDZ domain MAGUK_N_PEST PF10608.7 NM_007864.3_1 - 2e-13 50.7 4.9 1.4e-09 38.4 0.8 2.5 1 1 1 2 2 2 2 Polyubiquitination (PEST) N-terminal domain of MAGUK SH3_1 PF00018.26 NM_007864.3_1 - 2.7e-08 33.2 0.0 6.5e-08 31.9 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_007864.3_1 - 2.8e-08 33.2 0.0 8e-08 31.7 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_007864.3_1 - 0.01 15.6 0.1 0.03 14.0 0.1 1.9 1 0 0 1 1 1 0 Variant SH3 domain Crystall PF00030.17 NM_007773.4_2 - 1.7e-59 197.8 0.3 3.5e-30 103.9 0.0 2.2 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 NM_007773.4_2 - 1.8e-06 27.7 0.0 0.0099 15.7 0.0 2.3 2 0 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 NM_007773.4_2 - 3.7e-05 23.7 0.3 0.16 12.0 0.1 3.3 3 0 0 3 3 3 2 Beta/Gamma crystallin CTP_transf_like PF01467.24 NM_001163159.1_1 - 6.4e-31 107.3 0.0 1.1e-30 106.6 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like DUF1664 PF07889.10 NM_001163159.1_1 - 0.2 11.5 1.2 0.34 10.8 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) YtxH PF12732.5 NM_001163159.1_1 - 1.4 9.4 3.4 2.6 8.5 3.4 1.4 1 0 0 1 1 1 0 YtxH-like protein ubiquitin PF00240.21 NM_023137.3_1 - 2.9e-23 81.3 5.1 5e-11 42.0 1.5 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.6 NM_023137.3_1 - 6.3e-08 32.2 0.5 6.3e-05 22.6 0.2 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 NM_023137.3_1 - 0.06 13.7 2.4 2.1 8.7 0.1 2.6 2 2 0 2 2 2 0 Ubiquitin-like domain DAGK_acc PF00609.17 NM_019505.3_1 - 2.1e-49 167.8 0.0 3.1e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 NM_019505.3_1 - 1.6e-21 76.1 0.0 2.5e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 NM_019505.3_1 - 1.9e-09 37.1 38.3 4.9e-06 26.2 13.5 3.2 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) LMBR1 PF04791.14 NM_177178.3_3 - 1.7e-186 620.9 19.7 2.2e-186 620.5 19.7 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein NAD_binding_5 PF07994.10 NM_177178.3_3 - 3 7.0 4.5 0.55 9.4 0.3 1.7 2 0 0 2 2 2 0 Myo-inositol-1-phosphate synthase SH3_1 PF00018.26 NM_001082414.2_3 - 7.8e-58 191.7 2.6 1.6e-13 49.8 0.0 6.1 6 0 0 6 6 6 5 SH3 domain SH3_9 PF14604.4 NM_001082414.2_3 - 6.7e-53 176.2 1.0 2.4e-12 46.4 0.0 5.7 5 0 0 5 5 5 5 Variant SH3 domain SH3_2 PF07653.15 NM_001082414.2_3 - 5.6e-47 157.1 0.2 1.7e-09 37.1 0.0 5.5 5 0 0 5 5 5 5 Variant SH3 domain Trypsin PF00089.24 NM_011178.2_1 - 1.8e-58 197.8 0.0 2.3e-58 197.5 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_011178.2_1 - 1.8e-07 31.4 0.0 4.5e-07 30.1 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_011178.2_1 - 1.8e-05 25.6 0.0 2.6e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Pyocin_S PF06958.10 NM_177777.5_2 - 0.027 14.9 0.5 0.078 13.4 0.5 1.8 1 0 0 1 1 1 0 S-type Pyocin BTB PF00651.29 NM_001145038.1_3 - 3.2e-12 46.5 0.0 2.5e-10 40.4 0.0 3.3 1 1 2 3 3 3 1 BTB/POZ domain SOGA PF11365.6 NM_001114098.1_3 - 5.2e-65 216.5 50.9 7.1e-36 123.1 1.4 5.8 5 1 1 6 6 6 4 Protein SOGA DUF4482 PF14818.4 NM_001114098.1_3 - 4.1e-37 128.0 6.8 4.1e-37 128.0 6.8 5.4 4 1 0 5 5 5 1 Domain of unknown function (DUF4482) TSC22 PF01166.16 NM_001114098.1_3 - 0.88 9.8 40.7 0.15 12.3 2.1 7.2 6 0 0 6 6 6 0 TSC-22/dip/bun family zf-H2C2_2 PF13465.4 NM_011759.3_2 - 1.5e-21 75.7 39.0 1e-07 31.9 3.2 5.6 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 NM_011759.3_2 - 1e-15 57.1 32.5 8e-05 22.7 3.4 5.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_011759.3_2 - 4.3e-10 39.4 29.1 0.0077 16.8 1.5 5.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_011759.3_2 - 0.0004 20.1 23.8 0.4 10.6 1.9 4.8 4 0 0 4 4 4 3 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_011759.3_2 - 0.0073 16.3 17.0 0.39 10.8 3.1 3.3 1 1 2 3 3 3 3 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_011759.3_2 - 0.033 14.8 9.2 0.27 11.9 0.7 2.7 1 1 1 2 2 2 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_011759.3_2 - 6.1 7.2 15.1 5.4 7.3 0.3 4.3 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Toxin_2 PF00451.17 NM_011759.3_3 - 3.8 7.8 8.2 0.71 10.1 1.7 3.0 2 0 0 2 2 2 0 Scorpion short toxin, BmKK2 Sema PF01403.17 NM_001304329.1_2 - 9.1e-150 499.0 0.0 1.8e-149 498.0 0.0 1.5 1 1 1 2 2 2 1 Sema domain PSI PF01437.23 NM_001304329.1_2 - 1.1e-06 28.9 3.4 3e-06 27.5 3.4 1.8 1 0 0 1 1 1 1 Plexin repeat I-set PF07679.14 NM_001304329.1_2 - 0.00074 19.4 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001304329.1_2 - 0.00088 19.7 0.0 0.0033 17.9 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 NM_001304329.1_2 - 0.037 14.0 0.0 0.095 12.7 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain DUF1049 PF06305.9 NM_001304329.1_2 - 0.57 9.9 2.0 1.3 8.8 2.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) CLU PF13236.4 NM_001081158.2_2 - 7.8e-86 287.3 0.0 1.2e-85 286.7 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.5 NM_001081158.2_2 - 2.1e-56 190.6 0.0 4.2e-56 189.6 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.4 NM_001081158.2_2 - 2.9e-22 78.6 7.1 1.7e-09 37.7 0.2 3.6 1 1 1 3 3 3 3 Tetratricopeptide repeat CLU_N PF15044.4 NM_001081158.2_2 - 4.5e-16 58.9 0.1 1e-15 57.8 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.4 NM_001081158.2_2 - 3.9e-09 36.0 3.4 2e-05 24.2 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF727 PF05303.10 NM_001081158.2_2 - 0.0063 16.4 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_2 PF07719.15 NM_001081158.2_2 - 0.022 14.7 0.9 0.2 11.7 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Pex16 PF08610.8 NM_145122.2_2 - 3.3e-88 295.8 3.1 3.9e-88 295.6 3.1 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) DDDD PF10161.7 NM_026914.1_3 - 9.6e-37 124.5 0.2 1.7e-36 123.7 0.2 1.4 1 0 0 1 1 1 1 Putative mitochondrial precursor protein Hox9_act PF04617.11 NM_013555.4_3 - 1.7e-47 162.5 8.9 2.8e-46 158.5 8.1 2.6 2 1 0 2 2 2 1 Hox9 activation region Homeobox PF00046.27 NM_013555.4_3 - 6.5e-20 70.6 6.1 9.8e-20 70.0 6.1 1.3 1 0 0 1 1 1 1 Homeobox domain HTH_23 PF13384.4 NM_013555.4_3 - 0.058 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Ada3 PF10198.7 NM_013555.4_3 - 0.21 11.6 0.1 0.36 10.8 0.1 1.3 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 Glyco_transf_29 PF00777.16 NM_009181.2_3 - 2.2e-72 243.6 0.3 4.6e-72 242.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase family 29 (sialyltransferase) RRM_1 PF00076.20 NM_001166637.1_1 - 3.6e-13 49.0 0.0 5.8e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.4 NM_001166637.1_1 - 0.00032 21.1 14.9 0.00032 21.1 14.9 3.5 2 2 2 4 4 3 1 C-terminal duplication domain of Friend of PRMT1 FYTT PF07078.9 NM_001166637.1_1 - 0.00064 19.1 0.1 0.00064 19.1 0.1 2.4 2 0 0 2 2 1 1 Forty-two-three protein DUF2360 PF10152.7 NM_001166637.1_1 - 0.0025 18.1 11.5 0.0034 17.7 11.5 1.2 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein (DUF2360) TFIIA PF03153.11 NM_001166637.1_1 - 0.0046 16.9 30.3 0.0056 16.6 30.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CPSF100_C PF13299.4 NM_001166637.1_1 - 0.0077 16.3 8.9 0.011 15.7 8.9 1.3 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Coilin_N PF15862.3 NM_001166637.1_1 - 0.009 15.7 15.3 0.014 15.1 15.3 1.3 1 0 0 1 1 1 1 Coilin N-terminus Pex14_N PF04695.11 NM_001166637.1_1 - 0.011 16.4 14.8 0.034 14.7 15.2 1.6 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DDHD PF02862.15 NM_001166637.1_1 - 0.012 15.6 11.9 0.016 15.2 11.9 1.2 1 0 0 1 1 1 0 DDHD domain eIF-3_zeta PF05091.10 NM_001166637.1_1 - 0.074 11.9 19.9 0.092 11.6 19.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Borrelia_P83 PF05262.9 NM_001166637.1_1 - 0.13 10.6 13.2 0.15 10.4 13.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SID-1_RNA_chan PF13965.4 NM_001166637.1_1 - 0.16 10.3 2.6 0.17 10.2 2.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NPR3 PF03666.11 NM_001166637.1_1 - 0.2 10.3 16.7 0.25 10.0 16.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_U57 PF05582.10 NM_001166637.1_1 - 0.28 10.3 10.6 0.4 9.8 10.6 1.2 1 0 0 1 1 1 0 YabG peptidase U57 EOS1 PF12326.6 NM_001166637.1_1 - 0.34 10.7 6.1 0.48 10.2 6.1 1.3 1 0 0 1 1 1 0 N-glycosylation protein DUF1510 PF07423.9 NM_001166637.1_1 - 0.47 9.7 21.7 0.66 9.2 21.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF913 PF06025.10 NM_001166637.1_1 - 0.48 9.2 8.0 0.59 8.9 8.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Gti1_Pac2 PF09729.7 NM_001166637.1_1 - 0.97 9.3 16.3 1.5 8.7 16.3 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4407 PF14362.4 NM_001166637.1_1 - 1.2 8.2 15.7 2 7.5 15.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MAJIN PF15077.4 NM_001166637.1_1 - 1.3 8.8 13.6 1.8 8.3 13.6 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein FAM60A PF15396.4 NM_001166637.1_1 - 3 7.6 13.7 4.5 7.1 13.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SpoIIP PF07454.9 NM_001166637.1_1 - 3 7.1 20.2 4.3 6.6 20.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.10 NM_001166637.1_1 - 3.2 7.4 22.9 4.6 6.8 22.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1764 PF08576.8 NM_001166637.1_1 - 3.9 8.2 19.5 8.4 7.2 19.5 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) LMBR1 PF04791.14 NM_001166637.1_1 - 4.4 5.9 4.9 5.1 5.7 4.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein EPL1 PF10513.7 NM_001166637.1_1 - 5.4 7.2 22.7 8.3 6.6 22.7 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF3306 PF11748.6 NM_001166637.1_1 - 7.7 7.3 18.4 16 6.3 18.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DUF2052 PF09747.7 NM_001166637.1_1 - 8.9 6.3 26.5 13 5.7 26.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Apt1 PF10351.7 NM_001166637.1_2 - 4.1 6.0 14.8 5.1 5.7 14.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Glyco_hydro_9 PF00759.17 NM_001166637.1_3 - 0.71 9.1 12.1 1 8.6 12.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 Filament PF00038.19 NM_001313949.1_2 - 1.8e-93 313.4 27.7 2.2e-93 313.1 27.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 NM_001313949.1_2 - 0.0023 17.8 2.9 0.0023 17.8 2.9 3.3 2 1 1 3 3 3 1 TPR/MLP1/MLP2-like protein RasGAP_C PF03836.13 NM_001313949.1_2 - 0.025 14.6 17.4 0.088 12.8 0.3 3.2 2 1 1 3 3 3 0 RasGAP C-terminus Prefoldin PF02996.15 NM_001313949.1_2 - 0.055 13.3 16.5 0.14 11.9 2.7 3.5 3 1 0 3 3 3 0 Prefoldin subunit Spc7 PF08317.9 NM_001313949.1_2 - 0.061 12.1 23.1 0.043 12.5 12.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Bacillus_HBL PF05791.9 NM_001313949.1_2 - 0.071 12.7 10.6 0.1 12.2 2.7 2.4 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Atg14 PF10186.7 NM_001313949.1_2 - 0.075 12.0 17.2 0.69 8.8 14.7 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlxA PF14282.4 NM_001313949.1_2 - 0.31 10.9 17.5 3.3 7.6 10.6 2.8 2 1 0 2 2 2 0 FlxA-like protein DUF4407 PF14362.4 NM_001313949.1_2 - 0.46 9.6 14.7 4.1 6.5 11.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF2461 PF09365.8 NM_001313949.1_2 - 0.5 10.1 4.1 23 4.7 0.0 2.9 3 0 0 3 3 3 0 Conserved hypothetical protein (DUF2461) DUF1664 PF07889.10 NM_001313949.1_2 - 0.58 10.0 15.7 0.87 9.5 2.0 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) ATG16 PF08614.9 NM_001313949.1_2 - 1.4 8.9 24.5 1.8 8.6 1.2 3.2 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.9 NM_001313949.1_2 - 3.1 8.1 17.7 2.1 8.6 0.7 3.8 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) GTP-bdg_M PF16360.3 NM_001313949.1_2 - 8.7 6.9 9.7 18 5.9 2.8 2.8 2 1 0 2 2 2 0 GTP-binding GTPase Middle Region SLY PF12485.6 NM_023380.2_3 - 1.5e-53 181.5 13.9 2.9e-53 180.6 13.9 1.5 1 0 0 1 1 1 1 Lymphocyte signaling adaptor protein SAM_2 PF07647.15 NM_023380.2_3 - 3.9e-10 39.6 0.2 7.3e-10 38.7 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_023380.2_3 - 5.7e-09 36.2 0.1 1e-08 35.3 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.15 NM_023380.2_3 - 3.7e-05 23.2 0.0 9.6e-05 21.9 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 NM_023380.2_3 - 0.015 14.7 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 SH3 domain GTSE1_N PF15259.4 NM_013882.2_3 - 4e-58 195.6 1.4 6.6e-58 194.9 0.1 2.0 2 0 0 2 2 2 1 G-2 and S-phase expressed 1 RGS-like PF09128.9 NM_001130150.1_3 - 3.2e-75 251.8 0.1 3.2e-75 251.8 0.1 1.7 2 0 0 2 2 2 1 Regulator of G protein signalling-like domain RhoGEF PF00621.18 NM_001130150.1_3 - 4.7e-36 124.6 0.0 9e-36 123.7 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.3 NM_001130150.1_3 - 0.001 18.8 0.1 0.0022 17.8 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_7 PF13499.4 NM_028483.1_1 - 1.3e-09 38.3 4.9 1.4e-09 38.2 3.5 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_028483.1_1 - 3.5e-09 35.4 2.1 0.00029 20.0 0.7 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_028483.1_1 - 5.6e-08 32.0 2.5 7.4e-05 22.3 0.4 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.4 NM_028483.1_1 - 0.0017 17.9 3.3 0.0045 16.6 3.1 1.8 1 1 1 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_028483.1_1 - 0.012 15.8 0.9 0.041 14.1 0.9 1.8 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.4 NM_028483.1_1 - 0.013 14.9 1.3 0.11 11.9 0.4 2.4 2 0 0 2 2 2 0 EF hand EF-hand_4 PF12763.5 NM_028483.1_1 - 0.032 14.0 1.0 0.093 12.6 0.5 1.9 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand LXG PF04740.10 NM_028483.1_1 - 0.065 12.8 0.1 0.096 12.3 0.1 1.2 1 0 0 1 1 1 0 LXG domain of WXG superfamily Spore_III_AB PF09548.8 NM_028483.1_1 - 0.12 12.3 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) HLH PF00010.24 NM_019544.1_1 - 2.4e-12 46.5 0.7 4.3e-12 45.7 0.7 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Sushi PF00084.18 NM_001252567.1_3 - 9.4e-44 147.7 27.3 3.7e-09 36.9 0.3 5.5 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) CUB PF00431.18 NM_001252567.1_3 - 3.3e-25 88.4 0.0 4e-12 46.3 0.0 3.8 3 1 0 3 3 3 3 CUB domain cEGF PF12662.5 NM_001252567.1_3 - 0.47 10.3 10.7 7 6.6 0.1 4.9 5 0 0 5 5 5 0 Complement Clr-like EGF-like BTB_3 PF16017.3 NM_133700.2_3 - 3.7e-50 168.3 0.0 6.1e-50 167.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.20 NM_133700.2_3 - 0.0023 18.1 0.0 0.0065 16.7 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain Mito_carr PF00153.25 NM_001290558.1_1 - 1.2e-71 236.6 2.9 3.9e-24 84.2 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.4 NM_001290558.1_1 - 5.5e-14 52.3 1.3 1.9e-10 40.9 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_001290558.1_1 - 3.3e-12 44.9 3.2 0.0041 16.4 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 NM_001290558.1_1 - 2.9e-10 39.1 3.4 0.00076 19.1 0.2 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.4 NM_001290558.1_1 - 1.3e-06 28.0 1.6 0.021 14.5 0.1 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_001290558.1_1 - 2.7e-06 26.5 1.6 0.005 16.2 0.1 3.2 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.7 NM_001290558.1_1 - 0.006 16.8 1.4 0.011 15.9 1.4 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.4 NM_001290558.1_1 - 0.012 15.3 0.5 2.4 7.9 0.0 3.1 2 1 1 3 3 3 0 EF hand DUF2624 PF11116.6 NM_001290558.1_1 - 0.16 12.7 0.0 0.3 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) EF-hand_4 PF12763.5 NM_001290558.1_1 - 0.25 11.2 2.4 1.2 9.0 0.2 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand PHD PF00628.27 NM_172705.2_1 - 7.5e-07 28.8 8.1 7.5e-07 28.8 8.1 2.5 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.4 NM_172705.2_1 - 1e-05 24.8 4.8 3.7e-05 23.0 4.8 2.0 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.20 NM_172705.2_1 - 1.2 9.0 9.4 0.15 11.8 2.8 2.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) NUDE_C PF04880.11 NM_172705.2_1 - 3.9 7.8 7.4 0.11 12.8 0.8 1.7 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region DUF4594 PF15266.4 NM_001136471.1_2 - 1.1e-57 195.1 26.5 1.1e-57 195.1 26.5 3.1 3 1 1 4 4 4 1 Domain of unknown function (DUF4594) TRAP_alpha PF03896.14 NM_001136471.1_2 - 6.3 5.8 7.9 13 4.7 7.9 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit 7tm_4 PF13853.4 NM_147029.1_1 - 3.4e-54 184.3 18.7 4e-54 184.1 18.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147029.1_1 - 4.5e-18 65.3 18.9 2e-17 63.2 18.9 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PWWP PF00855.15 NM_008739.3_1 - 7.5e-34 115.9 4.2 9.5e-18 64.3 0.2 2.9 2 0 0 2 2 2 2 PWWP domain SET PF00856.26 NM_008739.3_1 - 7.4e-21 75.1 0.2 3.3e-20 73.0 0.2 2.3 1 0 0 1 1 1 1 SET domain PHD PF00628.27 NM_008739.3_1 - 7.8e-12 44.8 67.1 5.2e-06 26.1 10.2 6.6 4 2 2 6 6 6 4 PHD-finger NGP1NT PF08153.10 NM_008739.3_1 - 0.035 14.1 0.3 0.095 12.7 0.3 1.7 1 0 0 1 1 1 0 NGP1NT (NUC091) domain PHD_2 PF13831.4 NM_008739.3_1 - 2.9 7.3 45.3 0.0048 16.3 2.0 5.6 6 0 0 6 6 6 0 PHD-finger ubiquitin PF00240.21 NM_172809.3_2 - 0.0013 18.3 0.0 0.013 15.1 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family Pro-kuma_activ PF09286.9 NM_172809.3_2 - 0.011 15.9 0.2 1 9.5 0.1 2.3 2 0 0 2 2 2 0 Pro-kumamolisin, activation domain Tmemb_185A PF10269.7 NM_177601.3_2 - 2.9e-13 50.0 4.2 3.8e-13 49.6 4.2 1.2 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein Interfer-bind PF09294.8 NM_001110498.1_1 - 5.9e-17 61.8 0.2 1.7e-16 60.2 0.0 1.8 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.15 NM_001110498.1_1 - 9.7e-16 57.4 0.1 1.6e-15 56.6 0.1 1.3 1 0 0 1 1 1 1 Tissue factor fn3 PF00041.19 NM_001110498.1_1 - 0.0049 17.1 0.2 2.5 8.4 0.1 2.3 2 0 0 2 2 2 2 Fibronectin type III domain IL6Ra-bind PF09240.8 NM_001110498.1_1 - 0.088 13.1 0.3 0.15 12.3 0.3 1.3 1 0 0 1 1 1 0 Interleukin-6 receptor alpha chain, binding Med21 PF11221.6 NM_025315.3_3 - 1.7e-26 93.1 1.9 3.2e-26 92.2 1.9 1.4 1 1 0 1 1 1 1 Subunit 21 of Mediator complex 7tm_3 PF00003.20 NM_001105188.1_1 - 5.3e-57 193.2 33.2 5.3e-57 193.2 33.2 1.8 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001105188.1_1 - 2.2e-30 105.8 1.5 1.4e-29 103.1 1.5 2.0 1 1 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001105188.1_1 - 1e-18 66.9 9.8 2.4e-18 65.7 9.8 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR SCAN PF02023.15 NM_026107.3_3 - 3.7e-38 129.1 2.0 3.7e-38 129.1 2.0 2.1 3 0 0 3 3 3 1 SCAN domain zf-H2C2_2 PF13465.4 NM_026107.3_3 - 5.8e-29 99.1 45.2 1.9e-08 34.2 1.7 6.6 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.24 NM_026107.3_3 - 2.3e-20 71.7 47.7 7.3e-06 26.0 1.7 6.0 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_026107.3_3 - 3.1e-12 46.1 49.2 0.0025 18.4 2.8 6.0 6 0 0 6 6 5 5 C2H2-type zinc finger KRAB PF01352.25 NM_026107.3_3 - 1.3e-07 31.0 2.0 3.7e-07 29.6 2.0 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_026107.3_3 - 1.6e-06 28.1 29.6 0.013 15.7 1.6 5.8 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 NM_026107.3_3 - 0.0022 18.1 2.9 0.0022 18.1 2.9 3.6 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 NM_026107.3_3 - 0.0048 16.7 33.2 0.12 12.2 3.5 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_026107.3_3 - 0.028 14.1 0.5 0.028 14.1 0.5 4.0 4 0 0 4 4 4 0 zinc-finger C2H2-type Rpr2 PF04032.14 NM_026107.3_3 - 0.23 11.7 10.0 38 4.6 8.6 3.4 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Ta0938 PF11494.6 NM_026107.3_3 - 0.72 10.0 3.6 11 6.2 0.1 2.6 1 1 1 2 2 2 0 Ta0938 DUF3268 PF11672.6 NM_026107.3_3 - 0.73 10.1 12.1 3.7 7.8 0.4 3.2 2 1 1 3 3 3 0 zinc-finger-containing domain BolA PF01722.16 NM_026107.3_3 - 6.7 6.9 7.1 14 5.9 0.3 2.5 2 0 0 2 2 2 0 BolA-like protein Y_phosphatase PF00102.25 NM_011207.2_1 - 5e-78 261.8 1.3 6.8e-78 261.3 0.2 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase FERM_C PF09380.8 NM_011207.2_1 - 5.9e-24 84.1 1.5 1.4e-23 82.9 1.5 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain PDZ PF00595.22 NM_011207.2_1 - 1.3e-19 70.1 0.0 2.6e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FERM_M PF00373.16 NM_011207.2_1 - 3.9e-19 69.1 0.1 7.8e-19 68.1 0.1 1.5 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.8 NM_011207.2_1 - 8.7e-15 54.3 0.0 1.5e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 FERM N-terminal domain DSPc PF00782.18 NM_011207.2_1 - 4.1e-05 23.3 0.0 8e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_011207.2_1 - 0.00029 20.7 0.0 0.00051 19.9 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_011207.2_1 - 0.013 15.5 0.1 0.024 14.6 0.1 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate SRCR PF00530.16 NM_001128146.1_1 - 1.4e-172 561.2 91.8 2.5e-32 111.2 7.2 9.3 9 0 0 9 9 9 9 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 NM_001128146.1_1 - 3e-11 43.6 48.4 0.0034 17.7 0.4 8.2 9 0 0 9 9 9 5 Scavenger receptor cysteine-rich domain Gelsolin PF00626.20 NM_153153.3_3 - 2.1e-21 75.4 0.0 1.1e-06 28.3 0.0 5.8 5 0 0 5 5 5 4 Gelsolin repeat VHP PF02209.17 NM_153153.3_3 - 1.5e-15 56.8 0.8 1.5e-15 56.8 0.8 2.0 2 0 0 2 2 2 1 Villin headpiece domain DUF4695 PF15766.3 NM_153153.3_3 - 0.00025 21.1 11.4 0.14 12.3 0.1 4.0 2 1 1 3 3 3 3 Domain of unknown function (DUF4695) FinO_N PF12602.6 NM_153153.3_3 - 0.034 14.3 0.8 0.87 9.8 0.0 2.9 2 0 0 2 2 2 0 Fertility inhibition protein N terminal KAR PF15222.4 NM_153153.3_3 - 0.084 13.0 0.8 0.43 10.8 0.8 2.2 1 0 0 1 1 1 0 Kidney androgen-regulated 7tm_4 PF13853.4 NM_146877.1_1 - 2.4e-50 171.7 14.2 3.5e-50 171.2 14.2 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146877.1_1 - 3.3e-28 98.6 15.6 5.7e-28 97.8 15.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146877.1_1 - 3.4e-05 23.2 12.7 3.4e-05 23.2 12.7 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF3810 PF12725.5 NM_146877.1_1 - 0.0045 16.2 1.0 0.0045 16.2 1.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3810) DUF2096 PF09869.7 NM_172405.3_1 - 0.024 14.6 0.9 0.048 13.6 0.5 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) DUF3461 PF11944.6 NM_172405.3_1 - 0.045 13.7 0.8 0.087 12.8 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) DUF948 PF06103.9 NM_172405.3_1 - 0.71 10.0 2.2 0.94 9.7 0.5 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Pkinase PF00069.23 NM_027874.2_3 - 1.3e-26 93.4 0.0 1.8e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_027874.2_3 - 2.6e-16 59.6 0.0 3.4e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_027874.2_3 - 0.0021 17.9 0.0 0.0051 16.6 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 NM_027874.2_3 - 0.18 10.6 0.1 0.28 10.0 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ASC PF00858.22 NM_001310474.1_1 - 1.9e-58 198.3 0.0 2.3e-58 198.0 0.0 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel ASC PF00858.22 NM_001310474.1_3 - 4.3e-18 65.4 0.0 6.2e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel HMG_box PF00505.17 NM_001098799.1_3 - 1.4e-17 63.7 0.4 2.5e-17 62.9 0.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_001098799.1_3 - 9.4e-13 48.4 0.7 1.7e-12 47.6 0.7 1.4 1 0 0 1 1 1 1 HMG-box domain GET2 PF08690.8 NM_001098799.1_3 - 0.22 11.0 4.9 0.32 10.5 4.9 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 CNDH2_C PF16858.3 NM_001098799.1_3 - 0.23 11.2 4.6 0.36 10.6 4.6 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term YABBY PF04690.11 NM_001098799.1_3 - 0.47 10.9 2.3 0.51 10.7 1.5 1.4 1 1 0 1 1 1 0 YABBY protein Methyltransf_4 PF02390.15 NM_010792.1_3 - 1.1e-60 204.0 0.0 1.3e-60 203.6 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.4 NM_010792.1_3 - 0.013 16.1 0.0 0.024 15.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.10 NM_010792.1_3 - 0.18 12.4 0.0 0.36 11.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Neur_chan_LBD PF02931.21 NM_008066.3_1 - 2.7e-49 167.4 0.0 3.9e-49 166.9 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_008066.3_1 - 4.9e-38 131.4 6.2 1.4e-30 107.0 5.1 2.3 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Bac_surface_Ag PF01103.21 NM_008066.3_1 - 0.018 14.4 0.1 1.1 8.6 0.0 2.2 2 0 0 2 2 2 0 Surface antigen Serpin PF00079.18 NM_011453.6_1 - 8.4e-120 400.3 0.3 2.9e-119 398.6 0.0 1.7 2 0 0 2 2 2 1 Serpin (serine protease inhibitor) HLH PF00010.24 NM_033218.1_3 - 2.4e-16 59.3 0.7 6.1e-16 58.0 0.7 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Branch PF02485.19 NM_008105.3_1 - 4.8e-58 196.4 0.0 7.1e-58 195.9 0.0 1.3 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Pkinase_Tyr PF07714.15 NM_010143.1_1 - 2.6e-93 311.9 0.0 3.6e-93 311.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 NM_010143.1_1 - 8.8e-72 240.7 0.2 1.3e-71 240.2 0.2 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 NM_010143.1_1 - 8e-45 153.1 0.0 1.1e-44 152.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 NM_010143.1_1 - 3.9e-32 110.3 4.1 4.3e-15 55.7 0.0 3.3 4 0 0 4 4 4 2 Fibronectin type III domain SAM_1 PF00536.28 NM_010143.1_1 - 1.7e-21 76.3 0.0 3.1e-21 75.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.4 NM_010143.1_1 - 1.9e-21 76.5 0.2 4.8e-21 75.2 0.2 1.7 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_2 PF07647.15 NM_010143.1_1 - 1.3e-20 73.1 0.0 2.3e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.11 NM_010143.1_1 - 4.1e-06 26.3 9.2 4.1e-06 26.3 9.2 2.7 2 1 1 3 3 3 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.3 NM_010143.1_1 - 2.7e-05 24.5 0.0 0.0013 19.1 0.1 2.5 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 NM_010143.1_1 - 0.00057 19.9 0.0 0.31 11.1 0.0 2.7 3 0 0 3 3 3 1 Fibronectin type III domain Interfer-bind PF09294.8 NM_010143.1_1 - 0.007 16.5 0.0 0.29 11.3 0.0 2.6 3 0 0 3 3 2 1 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.7 NM_010143.1_1 - 0.018 15.4 0.0 9.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) Cadherin_C_2 PF16492.3 NM_010143.1_1 - 0.14 12.8 0.4 0.75 10.5 0.0 2.4 3 0 0 3 3 2 0 Cadherin cytoplasmic C-terminal DEC-1_N PF04625.11 NM_010143.1_3 - 9.5 5.0 6.9 15 4.3 6.9 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Guanylate_cyc PF00211.18 NM_001291910.1_1 - 5.3e-115 381.3 0.8 2.8e-62 209.5 0.2 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF512 PF04459.10 NM_001291910.1_1 - 0.064 12.4 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF512) DUF1053 PF06327.12 NM_001291910.1_1 - 0.087 13.3 0.2 0.24 11.8 0.2 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) AC_N PF16214.3 NM_001291910.1_1 - 0.19 10.7 0.0 0.19 10.7 0.0 2.7 4 0 0 4 4 4 0 Adenylyl cyclase N-terminal extracellular and transmembrane region zf-DBF PF07535.10 NM_001285937.1_3 - 6.7e-06 26.0 0.9 6.7e-06 26.0 0.9 2.1 2 0 0 2 2 2 1 DBF zinc finger DUF4187 PF13821.4 NM_001285937.1_3 - 0.62 9.8 8.3 5.1 6.8 2.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4187) Ig_3 PF13927.4 NM_172506.2_1 - 1.5e-51 172.8 1.8 7.5e-15 55.2 0.0 5.4 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 NM_172506.2_1 - 4e-48 161.3 0.0 6.6e-17 61.2 0.0 4.8 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_172506.2_1 - 9.4e-37 125.1 0.1 5.3e-11 42.6 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 NM_172506.2_1 - 5e-34 116.2 0.0 4.2e-09 36.3 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain fn3 PF00041.19 NM_172506.2_1 - 4.2e-33 113.4 2.4 2.6e-12 46.8 0.0 3.8 3 0 0 3 3 3 3 Fibronectin type III domain ISET-FN3_linker PF16625.3 NM_172506.2_1 - 8.2e-26 90.2 14.4 8.2e-26 90.2 14.4 3.5 3 0 0 3 3 2 1 Unstructured linking region I-set and fnIII on Brother of CDO V-set PF07686.15 NM_172506.2_1 - 1.5e-15 57.2 5.4 0.011 15.8 0.0 8.6 5 3 1 6 6 6 3 Immunoglobulin V-set domain C1-set PF07654.13 NM_172506.2_1 - 1.3e-08 35.0 0.9 0.15 12.4 0.1 4.6 4 0 0 4 4 4 3 Immunoglobulin C1-set domain Ig_5 PF16681.3 NM_172506.2_1 - 7.1e-08 32.6 0.0 0.085 13.2 0.0 4.4 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 NM_172506.2_1 - 2e-07 30.9 0.6 0.019 14.9 0.0 4.1 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.3 NM_172506.2_1 - 4.7e-06 26.9 0.8 2 8.9 0.0 4.1 4 0 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain Ig_4 PF16680.3 NM_172506.2_1 - 1.3e-05 25.3 0.0 0.63 10.3 0.0 4.6 5 0 0 5 5 4 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 NM_172506.2_1 - 7.3e-05 22.6 0.0 1.2 9.1 0.0 4.0 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain Y_Y_Y PF07495.11 NM_172506.2_1 - 0.026 14.3 0.0 0.084 12.7 0.0 1.9 1 0 0 1 1 1 0 Y_Y_Y domain Trypsin PF00089.24 NM_001081063.1_1 - 2.4e-60 204.0 0.0 2.9e-60 203.7 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_001081063.1_1 - 2.4e-05 24.5 0.0 4.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) UPAR_LY6 PF00021.19 NM_001135689.1_2 - 5.8e-18 65.2 13.2 5.8e-18 65.2 13.2 1.5 2 0 0 2 2 2 1 u-PAR/Ly-6 domain Toxin_1 PF00087.19 NM_001135689.1_2 - 0.3 11.2 19.2 0.085 13.0 15.4 2.0 2 1 0 2 2 2 0 Snake toxin WD40 PF00400.30 NM_011941.3_3 - 5.5e-35 118.7 23.9 0.011 16.4 0.0 12.8 12 0 0 12 12 12 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_011941.3_3 - 1.7e-12 47.3 0.0 0.022 14.9 0.0 6.2 5 2 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_011941.3_3 - 0.00027 20.7 0.0 0.0029 17.3 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.3 NM_011941.3_3 - 0.03 13.5 1.4 4.6 6.4 0.1 3.7 4 0 0 4 4 4 0 WD40-like domain p450 PF00067.20 NM_022434.2_2 - 1.2e-134 449.4 0.0 1.5e-134 449.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PIP5K PF01504.16 NM_001293707.1_3 - 1.3e-92 309.7 0.0 1.8e-92 309.4 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Zip PF02535.20 NM_033509.4_1 - 5.1 6.1 12.4 8.5 5.3 12.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Strabismus PF06638.9 NM_033509.4_2 - 8.4e-250 829.6 0.2 1.2e-249 829.0 0.2 1.2 1 0 0 1 1 1 1 Strabismus protein Cor1 PF04803.10 NM_001293680.1_3 - 3.7e-37 127.4 14.8 5.1e-37 126.9 14.8 1.2 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region YlbD_coat PF14071.4 NM_001293680.1_3 - 0.013 15.6 3.9 0.029 14.5 3.4 1.8 1 1 0 1 1 1 0 Putative coat protein KxDL PF10241.7 NM_001293680.1_3 - 0.41 10.8 6.7 0.4 10.9 5.1 1.7 1 1 1 2 2 2 0 Uncharacterized conserved protein HSCB_C PF07743.11 NM_001293680.1_3 - 0.82 10.1 4.4 1.6 9.2 3.9 1.7 1 1 0 1 1 1 0 HSCB C-terminal oligomerisation domain Ecm29 PF13001.5 NM_172381.2_1 - 2e-151 504.9 0.2 2e-151 504.9 0.2 3.9 5 0 0 5 5 5 1 Proteasome stabiliser HEAT PF02985.20 NM_172381.2_1 - 9.2e-16 56.4 11.1 0.19 11.9 0.1 11.7 13 0 0 13 13 12 4 HEAT repeat HEAT_2 PF13646.4 NM_172381.2_1 - 7.9e-14 51.7 4.5 0.17 12.1 0.0 8.7 8 1 1 9 9 9 3 HEAT repeats Vac14_Fab1_bd PF12755.5 NM_172381.2_1 - 1e-11 45.1 0.4 0.00062 20.2 0.1 7.4 7 1 1 8 8 8 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.4 NM_172381.2_1 - 6.6e-11 42.3 18.4 0.47 10.8 0.0 12.6 13 2 1 14 14 14 2 HEAT-like repeat Adaptin_N PF01602.18 NM_172381.2_1 - 6.7e-05 21.5 10.8 0.18 10.2 0.3 6.2 6 2 0 7 7 7 2 Adaptin N terminal region CLASP_N PF12348.6 NM_172381.2_1 - 0.0073 15.8 8.5 6.2 6.2 0.1 5.4 5 1 1 6 6 6 2 CLASP N terminal IFRD PF05004.11 NM_172381.2_1 - 0.014 14.4 12.4 0.16 11.0 0.0 5.5 5 0 0 5 5 5 0 Interferon-related developmental regulator (IFRD) SapB_2 PF03489.15 NM_172381.2_1 - 0.13 12.3 0.2 0.55 10.3 0.2 2.3 1 0 0 1 1 1 0 Saposin-like type B, region 2 DUF2205 PF10224.7 NM_172381.2_1 - 0.13 12.2 1.9 20 5.1 0.3 3.3 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) RTP1_C1 PF10363.7 NM_172381.2_1 - 0.32 11.0 4.7 11 6.1 0.1 5.4 7 0 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_C PF12460.6 NM_172381.2_1 - 1.1 8.2 14.1 0.067 12.2 0.4 5.1 7 0 0 7 7 7 0 RNAPII transcription regulator C-terminal Glyco_hydro_31 PF01055.24 NM_008064.4_3 - 6.3e-164 546.2 0.1 7.6e-164 545.9 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.3 NM_008064.4_3 - 5.6e-31 107.0 0.0 9.4e-31 106.3 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.16 NM_008064.4_3 - 2.7e-15 55.8 7.0 6.6e-15 54.6 7.0 1.7 1 0 0 1 1 1 1 Trefoil (P-type) domain Gal_mutarotas_2 PF13802.4 NM_008064.4_3 - 6.4e-13 48.7 0.0 1.9e-12 47.2 0.0 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.2 NM_008064.4_3 - 0.002 18.3 0.0 0.0042 17.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) RabGAP-TBC PF00566.16 NM_194334.2_2 - 2.5e-58 197.1 3.4 2.5e-58 197.1 3.4 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain PH PF00169.27 NM_194334.2_2 - 6.1e-07 29.8 0.0 1.3e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 PH domain DUF1664 PF07889.10 NM_194334.2_2 - 0.024 14.5 4.0 2.6 7.9 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Trimer_CC PF08954.9 NM_194334.2_2 - 0.035 13.5 0.5 0.15 11.5 0.5 2.2 1 0 0 1 1 1 0 Trimerisation motif PH_8 PF15409.4 NM_194334.2_2 - 0.069 13.3 0.0 0.21 11.8 0.0 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain KRAB PF01352.25 NM_194334.2_2 - 0.083 12.5 0.1 0.22 11.1 0.1 1.6 1 0 0 1 1 1 0 KRAB box DUF722 PF05263.9 NM_194334.2_2 - 0.25 11.4 1.0 17 5.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF722) Mnd1 PF03962.13 NM_194334.2_2 - 0.36 10.5 9.1 3.4 7.4 1.7 2.4 2 0 0 2 2 2 0 Mnd1 family Spc29 PF17082.3 NM_194334.2_2 - 0.59 9.8 3.9 1.8 8.2 0.1 2.6 3 0 0 3 3 3 0 Spindle Pole Component 29 T4SS PF07996.9 NM_194334.2_2 - 0.82 9.9 5.9 0.12 12.7 2.1 1.5 2 0 0 2 2 1 0 Type IV secretion system proteins TMF_DNA_bd PF12329.6 NM_194334.2_2 - 0.96 9.4 21.3 0.44 10.4 0.5 3.7 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Med9 PF07544.11 NM_194334.2_2 - 1 9.4 8.1 1 9.4 4.3 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 HAP1_N PF04849.11 NM_194334.2_2 - 6.6 5.7 21.4 8 5.4 10.4 2.5 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Ras PF00071.20 NM_026967.4_1 - 1.4e-42 144.9 0.0 1.8e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_026967.4_1 - 2.2e-16 60.0 0.0 3.4e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_026967.4_1 - 3.4e-05 23.2 0.0 5e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_026967.4_1 - 0.0014 18.5 0.0 0.0021 18.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 NM_026967.4_1 - 0.0078 15.6 0.0 0.026 13.9 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 NM_026967.4_1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF258 PF03193.14 NM_026967.4_1 - 0.035 13.9 0.0 0.83 9.4 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function, DUF258 AAA_14 PF13173.4 NM_026967.4_1 - 0.08 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Peptidase_S24 PF00717.21 NM_019951.1_3 - 2.7e-09 36.7 0.1 4.2e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like FGGY_N PF00370.19 NM_010293.3_2 - 3.3e-87 292.0 0.1 4.6e-87 291.5 0.1 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.14 NM_010293.3_2 - 6.8e-63 211.9 1.4 1.1e-62 211.2 0.8 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain RA PF00788.21 NM_027760.2_3 - 3.9e-08 33.7 0.0 8.8e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SWI-SNF_Ssr4 PF08549.8 NM_027760.2_3 - 0.00025 19.7 11.0 0.00035 19.2 11.0 1.1 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1750) TBPIP PF07106.11 NM_027760.2_3 - 0.014 15.0 32.1 0.018 14.7 9.3 3.1 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Reo_sigmaC PF04582.10 NM_027760.2_3 - 0.02 14.2 1.7 1.7 7.8 0.1 2.4 1 1 0 2 2 2 0 Reovirus sigma C capsid protein ABM PF03992.14 NM_027760.2_3 - 0.034 14.1 1.4 5.8 7.0 0.0 2.9 3 0 0 3 3 3 0 Antibiotic biosynthesis monooxygenase Tropomyosin PF00261.18 NM_027760.2_3 - 0.2 10.9 32.6 0.69 9.1 19.5 2.1 1 1 1 2 2 2 0 Tropomyosin DUF2746 PF10874.6 NM_027760.2_3 - 0.58 10.4 2.5 1 9.7 0.8 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2746) Prefoldin PF02996.15 NM_027760.2_3 - 0.91 9.3 18.7 0.96 9.2 0.2 4.4 3 2 1 4 4 4 0 Prefoldin subunit Baculo_PEP_C PF04513.10 NM_027760.2_3 - 1 9.3 10.3 4.7 7.1 0.3 3.3 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Flagellin_N PF00669.18 NM_027760.2_3 - 1.1 9.2 5.0 12 5.9 0.2 2.5 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region DIT1_PvcA PF05141.10 NM_027760.2_3 - 1.8 7.8 5.3 3.2 7.0 5.3 1.4 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein Fib_alpha PF08702.8 NM_027760.2_3 - 2.1 8.4 21.9 0.52 10.3 3.8 3.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family GPW_gp25 PF04965.12 NM_027760.2_3 - 7.9 6.2 8.0 1.4 8.6 2.7 2.5 2 1 1 3 3 3 0 Gene 25-like lysozyme FUSC PF04632.10 NM_027760.2_3 - 8.4 4.7 7.6 1.2 7.4 0.1 2.2 2 0 0 2 2 2 0 Fusaric acid resistance protein family PID PF00640.21 NM_001202446.1_1 - 1.2e-34 119.2 0.2 1.8e-34 118.6 0.2 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH3_9 PF14604.4 NM_001202446.1_1 - 2.6e-14 52.6 0.2 1.1e-13 50.7 0.2 2.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001202446.1_1 - 2.7e-06 26.7 0.0 5.6e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001202446.1_1 - 0.0034 16.9 0.0 0.0087 15.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PID_2 PF14719.4 NM_001202446.1_1 - 0.0046 16.7 0.0 0.0075 16.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) zf-H2C2_2 PF13465.4 NM_001289634.1_3 - 8.8e-93 300.8 91.7 1.2e-08 34.8 0.5 13.5 13 0 0 13 13 12 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001289634.1_3 - 2.7e-68 222.6 101.2 1.1e-06 28.7 2.6 13.2 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001289634.1_3 - 5e-33 110.8 114.1 0.0011 19.5 2.5 14.0 13 0 0 13 13 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001289634.1_3 - 1.3e-23 82.3 76.5 0.0016 18.2 0.9 12.9 12 0 0 12 12 12 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001289634.1_3 - 1.9e-14 53.3 49.8 0.011 15.7 0.8 8.4 3 3 8 11 11 11 9 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001289634.1_3 - 3.7e-06 27.0 71.1 0.59 10.4 0.8 12.4 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_001289634.1_3 - 5.8e-06 26.5 38.8 0.19 11.9 0.6 6.4 6 0 0 6 6 6 4 zinc-finger-containing domain CpXC PF14353.4 NM_001289634.1_3 - 9.1e-06 25.6 44.0 0.97 9.3 0.1 10.6 10 2 1 11 11 11 5 CpXC protein XPA_N PF01286.16 NM_001289634.1_3 - 0.00091 19.1 54.7 1.7 8.6 0.1 12.1 12 0 0 12 12 12 4 XPA protein N-terminal Csm1 PF12539.6 NM_001289634.1_3 - 0.0087 16.5 7.8 13 6.4 0.2 5.7 5 1 1 6 6 5 0 Chromosome segregation protein Csm1/Pcs1 KRAB PF01352.25 NM_001289634.1_3 - 0.01 15.3 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 0 KRAB box zf-AN1 PF01428.14 NM_001289634.1_3 - 0.12 12.5 57.5 12 6.0 0.3 12.6 11 1 1 12 12 12 0 AN1-like Zinc finger zf-trcl PF13451.4 NM_001289634.1_3 - 0.13 12.1 42.7 8.3 6.3 0.1 11.5 11 1 1 12 12 12 0 Probable zinc-ribbon domain DAGK_cat PF00781.22 NM_020011.5_3 - 4.4e-27 94.1 0.0 6.4e-27 93.5 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain SNCAIP_SNCA_bd PF16700.3 NM_026408.4_1 - 3.5e-24 84.1 8.7 8.2e-24 82.9 8.7 1.7 1 0 0 1 1 1 1 Synphilin-1 alpha-Synuclein-binding domain Ank_2 PF12796.5 NM_026408.4_1 - 2.4e-16 59.9 1.2 6.2e-07 29.8 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_026408.4_1 - 3.9e-15 55.9 0.4 3e-05 24.3 0.0 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_026408.4_1 - 1e-13 51.0 0.8 0.0011 19.1 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_026408.4_1 - 1e-06 28.8 1.4 0.035 14.4 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 NM_026408.4_1 - 7.2e-05 22.8 0.3 1 10.0 0.2 4.1 4 0 0 4 4 4 2 Ankyrin repeat DAN PF03045.13 NM_201227.3_3 - 1.1e-20 73.5 3.9 1.8e-20 72.9 3.9 1.2 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.20 NM_201227.3_3 - 0.87 9.8 4.2 1.5 9.0 4.2 1.3 1 0 0 1 1 1 0 Cystine-knot domain Sclerostin PF05463.9 NM_201227.3_3 - 1.9 8.0 6.1 8.2 5.9 6.1 1.8 1 1 0 1 1 1 0 Sclerostin (SOST) Kinesin PF00225.21 NM_001102615.1_3 - 7.7e-110 366.8 1.3 1.3e-109 366.0 1.3 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 NM_001102615.1_3 - 6.9e-25 87.6 0.1 2.3e-24 85.9 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding Fib_alpha PF08702.8 NM_001102615.1_3 - 0.028 14.4 5.6 0.4 10.7 0.1 3.4 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family IstB_IS21 PF01695.15 NM_001102615.1_3 - 0.032 13.9 0.0 0.14 11.8 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein CIF PF16374.3 NM_001102615.1_3 - 0.034 14.1 0.0 0.21 11.5 0.0 2.0 2 0 0 2 2 2 0 Cycle inhibiting factor (CIF) TMF_DNA_bd PF12329.6 NM_001102615.1_3 - 0.11 12.4 4.1 0.19 11.6 1.3 2.9 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Peptidase_S49_N PF08496.8 NM_001102615.1_3 - 0.77 9.7 3.9 0.53 10.2 0.1 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DivIC PF04977.13 NM_001102615.1_3 - 3.3 7.4 6.8 5.6 6.7 1.4 2.7 2 0 0 2 2 2 0 Septum formation initiator eIF3g PF12353.6 NM_016876.3_1 - 6.4e-43 146.0 2.9 1e-42 145.4 2.9 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.20 NM_016876.3_1 - 7.8e-19 67.1 0.0 1.9e-18 65.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDV3 PF15359.4 NM_016876.3_1 - 0.0015 18.9 0.7 0.005 17.2 0.7 1.8 1 1 0 1 1 1 1 Carnitine deficiency-associated protein 3 RRM_occluded PF16842.3 NM_016876.3_1 - 0.031 14.0 0.0 0.064 13.0 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif RNA_bind PF08675.9 NM_016876.3_1 - 0.063 13.2 0.0 0.16 11.9 0.0 1.6 1 1 0 1 1 1 0 RNA binding domain Nup35_RRM_2 PF14605.4 NM_016876.3_1 - 0.067 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif CBM_21 PF03370.11 NM_001167908.1_2 - 2.4e-21 75.9 0.0 3.3e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 NM_001167908.1_2 - 1.7e-08 34.7 0.0 3e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) NUC129 PF08157.9 NM_023554.2_3 - 7.3e-31 106.2 0.2 2.2e-30 104.7 0.2 1.9 1 0 0 1 1 1 1 NUC129 domain TruB_N PF01509.16 NM_028115.3_3 - 3.8e-50 170.0 0.1 5.6e-50 169.5 0.1 1.2 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.3 NM_028115.3_3 - 9.5e-06 25.5 0.0 1.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain OGG_N PF07934.10 NM_010957.4_2 - 1.3e-34 118.8 0.3 1.8e-34 118.3 0.3 1.2 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.23 NM_010957.4_2 - 4.5e-20 72.0 0.0 2.8e-19 69.4 0.0 2.0 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.21 NM_010957.4_2 - 0.0012 18.5 0.1 0.0092 15.7 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix motif Trypsin PF00089.24 NM_010644.3_1 - 2.1e-68 230.3 0.0 2.4e-68 230.1 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_010644.3_1 - 3.1e-07 30.7 0.0 0.00011 22.4 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_010644.3_1 - 3.4e-05 24.6 0.0 8.7e-05 23.3 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.13 NM_010644.3_1 - 0.0041 16.6 0.0 1.6 8.1 0.0 2.1 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 HSP70 PF00012.18 NM_031165.4_1 - 4.8e-264 877.0 12.4 5.5e-264 876.8 12.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 NM_031165.4_1 - 1.4e-18 66.7 0.3 4.2e-17 61.8 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 NM_031165.4_1 - 0.00048 20.4 2.4 1.4 9.2 0.0 3.6 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 NM_031165.4_1 - 0.002 17.7 0.0 0.0051 16.4 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.18 NM_031165.4_1 - 0.014 14.8 0.1 5 6.4 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DDR PF08841.8 NM_031165.4_1 - 0.038 12.9 0.4 0.18 10.6 0.3 2.0 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain HORMA PF02301.16 NM_031165.4_1 - 0.073 12.5 1.2 0.17 11.3 1.2 1.6 1 0 0 1 1 1 0 HORMA domain Radial_spoke_3 PF06098.9 NM_031165.4_1 - 0.12 11.5 8.2 0.25 10.4 8.2 1.5 1 0 0 1 1 1 0 Radial spoke protein 3 Membralin PF09746.7 NM_031165.4_1 - 5 5.9 4.8 8.6 5.2 4.8 1.3 1 0 0 1 1 1 0 Tumour-associated protein LANC_like PF05147.11 NM_021295.3_3 - 1.1e-102 343.2 0.5 1.3e-102 342.9 0.5 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Glyco_hydro_127 PF07944.10 NM_021295.3_3 - 0.084 11.2 0.1 9 4.5 0.0 2.1 2 0 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_88 PF07470.11 NM_021295.3_3 - 0.2 10.6 0.1 0.91 8.4 0.1 1.8 2 0 0 2 2 2 0 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.11 NM_021295.3_3 - 0.52 9.7 2.4 11 5.3 0.1 3.0 2 1 1 3 3 3 0 D-glucuronyl C5-epimerase C-terminus VEGF_C PF14554.4 NM_009505.4_2 - 7e-28 96.4 21.3 7e-28 96.4 21.3 2.2 2 0 0 2 2 2 1 VEGF heparin-binding domain PDGF PF00341.15 NM_009505.4_2 - 8.8e-26 89.9 6.3 8.8e-26 89.9 6.3 2.3 3 0 0 3 3 3 1 PDGF/VEGF domain LRR_8 PF13855.4 NM_026253.4_3 - 1.7e-15 56.4 11.0 4.1e-09 35.9 2.1 3.2 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_026253.4_3 - 8.9e-14 51.2 17.1 2.3e-05 24.5 0.1 4.5 5 1 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_026253.4_3 - 0.011 15.9 8.0 31 5.4 0.0 5.8 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.4 NM_026253.4_3 - 8 6.7 9.9 14 5.9 0.4 4.8 5 0 0 5 5 5 0 Leucine Rich repeat IL6Ra-bind PF09240.8 NM_007781.3_3 - 3.7e-10 40.0 4.5 1.3e-06 28.6 0.1 2.6 2 0 0 2 2 2 2 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.8 NM_007781.3_3 - 6.1e-09 35.9 6.3 2.1e-06 27.7 0.0 2.8 3 0 0 3 3 3 2 Erythropoietin receptor, ligand binding IL4Ra_N PF09238.8 NM_007781.3_3 - 9.6e-08 32.1 3.0 0.0034 17.6 0.0 2.6 2 0 0 2 2 2 2 Interleukin-4 receptor alpha chain, N-terminal fn3 PF00041.19 NM_007781.3_3 - 4.2e-06 26.9 5.0 0.00012 22.2 0.3 3.5 4 0 0 4 4 4 1 Fibronectin type III domain Interfer-bind PF09294.8 NM_007781.3_3 - 6.2e-05 23.1 0.3 0.00015 21.9 0.3 1.6 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.3 NM_007781.3_3 - 0.0018 18.7 1.5 0.0052 17.2 1.5 1.8 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Voltage_CLC PF00654.18 NM_001302386.1_2 - 8e-109 364.0 18.8 1.7e-108 362.9 18.8 1.6 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.26 NM_001302386.1_2 - 2.5e-12 46.9 0.7 1.2e-06 28.7 0.1 2.4 2 0 0 2 2 2 2 CBS domain DUF4757 PF15949.3 NM_201529.2_2 - 1.7e-54 184.8 23.9 2.1e-44 151.9 17.1 6.3 4 1 2 6 6 6 2 Domain of unknown function (DUF4757) CH PF00307.29 NM_201529.2_2 - 4.9e-14 52.3 0.1 1.2e-13 51.0 0.1 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain LIM PF00412.20 NM_201529.2_2 - 5.7e-08 32.7 6.1 1.2e-07 31.7 6.1 1.6 1 0 0 1 1 1 1 LIM domain PDZ PF00595.22 NM_201529.2_2 - 2.7e-07 30.7 0.0 5.8e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_201529.2_2 - 5.1e-07 29.8 0.0 1.2e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain BAR PF03114.16 NM_001122641.1_2 - 5.9e-65 219.1 9.4 1.1e-64 218.2 9.4 1.4 1 0 0 1 1 1 1 BAR domain RhoGAP PF00620.25 NM_001122641.1_2 - 2.7e-43 147.3 0.0 6.6e-43 146.0 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain BAR_2 PF10455.7 NM_001122641.1_2 - 0.014 14.5 3.6 0.055 12.5 3.6 1.9 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Spt20 PF12090.6 NM_001122641.1_2 - 0.86 9.0 13.2 1.9 7.9 13.2 1.5 1 0 0 1 1 1 0 Spt20 family PT PF04886.10 NM_001253358.1_1 - 0.0006 19.2 4.0 0.0019 17.6 4.0 1.9 1 0 0 1 1 1 1 PT repeat BK_channel_a PF03493.16 NM_001253358.1_3 - 1.1e-32 112.1 0.2 2.3e-32 111.0 0.2 1.6 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.29 NM_001253358.1_3 - 1.1e-17 64.0 20.1 2.6e-17 62.8 20.1 1.5 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 NM_001253358.1_3 - 1.1e-13 50.8 4.1 1.1e-13 50.8 4.1 2.6 2 0 0 2 2 2 1 Ion channel TrkA_N PF02254.16 NM_001253358.1_3 - 4e-05 23.7 0.0 0.00023 21.2 0.0 2.2 2 0 0 2 2 2 1 TrkA-N domain PT PF04886.10 NM_001253358.1_3 - 0.00073 18.9 8.7 0.0015 17.9 8.7 1.4 1 0 0 1 1 1 1 PT repeat Lig_chan PF00060.24 NM_001253358.1_3 - 0.27 10.9 3.9 0.89 9.2 1.1 2.5 2 0 0 2 2 2 0 Ligand-gated ion channel SAM_1 PF00536.28 NM_144531.3_3 - 4.6e-27 94.1 3.4 5.1e-12 45.9 0.7 3.4 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_144531.3_3 - 1.6e-26 92.0 0.8 9.1e-11 41.6 0.0 3.5 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) Fez1 PF06818.13 NM_144531.3_3 - 0.00033 21.0 15.7 0.0045 17.3 10.0 2.6 2 0 0 2 2 2 2 Fez1 SAM_PNT PF02198.14 NM_144531.3_3 - 0.025 14.4 1.3 3.4 7.6 0.1 3.0 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain DUF148 PF02520.15 NM_144531.3_3 - 0.033 14.2 5.5 0.08 12.9 5.5 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF148 Pkinase PF00069.23 NM_194446.2_3 - 3.1e-66 223.3 0.0 3.8e-66 223.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_194446.2_3 - 7.1e-32 110.6 0.0 9.5e-32 110.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_194446.2_3 - 2e-07 30.5 0.1 0.00032 20.0 0.0 2.1 1 1 1 2 2 2 2 Kinase-like RIO1 PF01163.20 NM_194446.2_3 - 0.027 14.0 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family zf-FPG_IleRS PF06827.12 NM_194446.2_3 - 0.053 13.3 0.6 0.12 12.1 0.6 1.7 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS Kdo PF06293.12 NM_194446.2_3 - 0.17 11.1 0.0 0.54 9.4 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Myotub-related PF06602.12 NM_001164191.1_2 - 6.4e-147 488.8 0.2 8.9e-147 488.4 0.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.18 NM_001164191.1_2 - 5e-20 71.3 0.0 9.9e-20 70.3 0.0 1.5 1 0 0 1 1 1 1 GRAM domain DSPc PF00782.18 NM_001164191.1_2 - 0.00031 20.4 0.0 0.00064 19.4 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 NM_001164191.1_2 - 0.00086 18.8 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase 3-PAP PF12578.6 NM_001164191.1_2 - 0.0011 18.6 0.1 0.002 17.7 0.1 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein Y_phosphatase3 PF13350.4 NM_001164191.1_2 - 0.031 14.1 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family PDEase_I PF00233.17 NM_019840.2_1 - 2.7e-93 312.0 4.8 2.7e-93 312.0 4.8 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase TM140 PF14985.4 NM_197986.2_3 - 5e-89 296.5 9.5 8e-89 295.9 9.5 1.3 1 0 0 1 1 1 1 TM140 protein family Gram_pos_anchor PF00746.19 NM_197986.2_3 - 5.9 6.9 6.2 1e+02 3.0 0.0 3.7 3 0 0 3 3 3 0 Gram positive anchor Mpv17_PMP22 PF04117.10 NM_001289562.1_3 - 1.6e-17 63.3 1.9 1.6e-17 63.3 1.9 2.2 2 0 0 2 2 2 1 Mpv17 / PMP22 family MAGP PF05507.9 NM_001161799.1_3 - 1.3e-42 145.3 0.6 1.9e-42 144.8 0.6 1.2 1 0 0 1 1 1 1 Microfibril-associated glycoprotein (MAGP) ShK PF01549.22 NM_001161799.1_3 - 0.0012 19.2 5.5 0.0012 19.2 5.5 1.9 2 0 0 2 2 2 1 ShK domain-like RUN PF02759.17 NM_027530.3_1 - 1.4e-31 109.1 0.4 5.5e-31 107.2 0.0 2.0 2 0 0 2 2 2 1 RUN domain Trimer_CC PF08954.9 NM_027530.3_1 - 0.00097 18.5 1.4 0.21 11.0 0.0 2.7 2 0 0 2 2 2 2 Trimerisation motif DUF2344 PF10105.7 NM_027530.3_1 - 0.51 10.0 3.0 1.1 8.9 3.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) EF-hand_7 PF13499.4 NM_001286083.1_3 - 7.5e-26 90.3 3.8 1.7e-17 63.5 0.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 NM_001286083.1_3 - 8.8e-24 81.1 5.1 1e-06 27.7 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.4 NM_001286083.1_3 - 2.7e-20 70.7 2.5 6.4e-07 28.5 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_001286083.1_3 - 5.5e-20 69.4 2.7 2.1e-05 24.0 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 NM_001286083.1_3 - 1.1e-16 60.2 2.3 4.5e-08 32.6 0.1 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.5 NM_001286083.1_3 - 1.8e-05 24.5 0.7 0.42 10.5 0.0 3.3 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 NM_001286083.1_3 - 2.8e-05 24.3 2.3 0.016 15.3 0.1 3.5 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.4 NM_001286083.1_3 - 0.016 14.9 0.2 6.6 6.5 0.0 2.6 2 0 0 2 2 2 0 EF hand Ephrin PF00812.15 NM_010108.1_2 - 4.9e-40 136.6 1.0 8.1e-40 135.9 1.0 1.3 1 0 0 1 1 1 1 Ephrin FLYWCH PF04500.14 NM_010108.1_2 - 1 9.4 4.7 9.8 6.3 0.4 2.3 2 0 0 2 2 2 0 FLYWCH zinc finger domain DUF4187 PF13821.4 NM_181649.6_1 - 9.8e-21 73.2 2.5 2.2e-20 72.1 2.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.21 NM_181649.6_1 - 1.4e-12 47.2 1.0 2.6e-12 46.3 1.0 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 NM_181649.6_1 - 2.7e-05 24.1 0.1 2.7e-05 24.1 0.1 2.1 2 0 0 2 2 2 1 G-patch domain SNF PF00209.16 NM_009320.4_1 - 3.4e-238 791.4 30.7 4.3e-238 791.1 30.7 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Ferlin_C PF16165.3 NM_010838.4_1 - 1.1 9.1 5.1 1.8 8.3 5.1 1.3 1 0 0 1 1 1 0 Ferlin C-terminus SART-1 PF03343.11 NM_010838.4_1 - 3.1 6.1 8.6 4.4 5.6 8.6 1.1 1 0 0 1 1 1 0 SART-1 family Tubulin-binding PF00418.17 NM_010838.4_3 - 5.6e-59 195.7 26.5 1.4e-16 60.1 3.3 5.6 5 0 0 5 5 5 4 Tau and MAP protein, tubulin-binding repeat Tmemb_cc2 PF10267.7 NM_010838.4_3 - 0.42 9.6 1.7 2.5 7.0 1.7 1.9 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Cylicin_N PF15241.4 NM_001162865.1_2 - 8.7e-43 144.7 0.1 8.7e-43 144.7 0.1 4.5 3 2 1 4 4 4 1 Cylicin N-terminus zf-C2H2 PF00096.24 NM_001110328.1_3 - 9.1e-33 110.8 73.6 1.5e-05 25.0 0.9 11.8 11 0 0 11 11 11 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001110328.1_3 - 8.1e-27 92.3 85.8 1.2e-07 31.7 0.4 13.1 14 1 0 14 14 12 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001110328.1_3 - 1.4e-22 78.3 90.4 0.00085 19.8 0.9 12.4 13 0 0 13 13 12 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001110328.1_3 - 4.5e-12 45.8 18.7 0.83 9.9 0.0 9.3 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001110328.1_3 - 0.00084 19.9 14.4 0.61 10.7 0.2 5.4 4 1 0 5 5 5 1 zinc-ribbon family zf-C2H2_6 PF13912.4 NM_001110328.1_3 - 0.0017 18.1 77.0 0.02 14.7 2.5 10.5 13 0 0 13 13 12 6 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001110328.1_3 - 0.0049 16.5 49.1 0.28 10.8 4.9 9.3 9 0 0 9 9 9 4 zinc-finger C2H2-type zf-Di19 PF05605.10 NM_001110328.1_3 - 0.023 14.8 32.3 0.93 9.7 2.0 6.8 7 0 0 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 NM_001110328.1_3 - 0.076 13.3 51.5 1.5 9.1 1.1 10.0 11 0 0 11 11 10 0 Zinc-finger of C2H2 type GAGA PF09237.9 NM_001110328.1_3 - 0.88 9.3 15.6 7.6 6.3 0.2 5.4 3 1 1 5 5 5 0 GAGA factor Cript PF10235.7 NM_001110328.1_3 - 1.6 9.2 0.0 1.6 9.2 0.0 3.0 3 0 0 3 3 2 0 Microtubule-associated protein CRIPT zf-C2H2_9 PF16293.3 NM_001110328.1_3 - 2.2 8.1 11.0 72 3.2 0.1 5.8 7 0 0 7 7 7 0 C2H2 type zinc-finger (1 copy) 7tm_4 PF13853.4 NM_001011534.1_1 - 2.4e-50 171.7 21.9 2.8e-50 171.5 21.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011534.1_1 - 9.9e-19 67.5 21.2 2.1e-18 66.4 21.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011534.1_1 - 6.1e-06 25.7 22.3 1.1e-05 24.9 22.3 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PNTB_4TM PF12769.5 NM_001011534.1_1 - 2.1 8.8 17.5 7.1 7.0 4.9 4.0 2 2 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch Metallothio PF00131.18 NM_013603.2_2 - 4e-20 71.6 61.5 4e-20 71.6 61.5 2.1 2 0 0 2 2 2 1 Metallothionein CASP_C PF08172.10 NM_001291238.1_2 - 2.2e-58 197.5 2.1 2.2e-58 197.5 2.1 5.5 2 2 2 4 4 4 1 CASP C terminal NDUF_B8 PF05821.9 NM_001291238.1_2 - 0.079 12.7 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) ZapB PF06005.10 NM_001291238.1_2 - 0.28 11.5 0.0 0.28 11.5 0.0 7.8 5 2 1 6 6 6 0 Cell division protein ZapB HOOK PF05622.10 NM_001291238.1_2 - 6.1 4.7 75.6 0.44 8.5 59.3 3.4 2 1 1 3 3 3 0 HOOK protein DUF4407 PF14362.4 NM_001291238.1_2 - 7.7 5.6 54.8 5.3 6.2 0.0 4.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) p450 PF00067.20 NM_145499.2_1 - 5.7e-157 523.0 0.2 6.5e-157 522.8 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 EF-hand_1 PF00036.30 NM_001310712.1_3 - 2.6e-29 98.4 12.4 2.2e-09 36.0 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 NM_001310712.1_3 - 5.1e-25 87.6 6.3 1.1e-14 54.5 0.8 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_001310712.1_3 - 1.6e-24 83.6 2.0 1e-08 34.3 0.1 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 NM_001310712.1_3 - 1.9e-21 75.4 7.4 8.2e-12 44.6 0.5 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 NM_001310712.1_3 - 7.6e-19 66.2 8.7 1.2e-07 30.7 0.1 3.6 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.4 NM_001310712.1_3 - 4.7e-08 33.1 0.1 0.0047 17.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.7 NM_001310712.1_3 - 0.0019 18.3 0.0 0.033 14.4 0.0 2.1 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.11 NM_001310712.1_3 - 0.0078 16.1 0.0 1.4 8.8 0.0 2.3 2 0 0 2 2 2 1 Tellurite resistance protein TerB EF-hand_4 PF12763.5 NM_001310712.1_3 - 0.065 13.0 0.2 0.39 10.6 0.0 2.1 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DIMCO_N PF16844.3 NM_001310712.1_3 - 0.077 13.2 0.0 0.23 11.7 0.0 1.8 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal POTRA_2 PF08479.9 NM_001310712.1_3 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 POTRA domain, ShlB-type Caleosin PF05042.11 NM_001310712.1_3 - 0.24 11.2 0.0 6.5 6.5 0.0 2.2 2 0 0 2 2 2 0 Caleosin related protein Med8 PF10232.7 NM_173719.3_3 - 1.3e-76 257.1 1.5 3.3e-75 252.5 1.5 2.0 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Baculo_PEP_C PF04513.10 NM_173719.3_3 - 0.081 12.8 0.0 16 5.4 0.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-Q PF13094.4 NM_173719.3_3 - 0.38 10.8 4.4 1.1 9.3 0.5 2.4 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit Defensin_propep PF00879.16 NM_001170955.1_1 - 3.7e-19 68.6 0.1 4.8e-19 68.3 0.1 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 NM_001170955.1_1 - 2.6e-10 40.5 17.2 3.4e-10 40.2 17.2 1.1 1 0 0 1 1 1 1 Mammalian defensin MF_alpha_N PF05436.9 NM_001170955.1_1 - 0.0023 17.7 0.0 0.0029 17.4 0.0 1.2 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus Voltage_CLC PF00654.18 NM_011930.4_3 - 1.2e-94 317.3 29.5 7.4e-94 314.7 27.4 2.1 2 0 0 2 2 2 2 Voltage gated chloride channel CBS PF00571.26 NM_011930.4_3 - 2.7e-16 59.6 0.1 1.1e-09 38.4 0.0 2.5 2 0 0 2 2 2 2 CBS domain Neuropep_like PF15161.4 NM_001310547.1_3 - 9.4e-40 134.0 2.6 1.4e-39 133.4 2.6 1.3 1 0 0 1 1 1 1 Neuropeptide-like TMEM132 PF16070.3 NM_175432.3_3 - 1.1e-141 472.0 3.4 1.5e-141 471.6 3.4 1.2 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_N PF15705.3 NM_175432.3_3 - 5.8e-53 178.1 0.0 1.9e-52 176.4 0.0 1.9 2 0 0 2 2 2 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term TMEM132D_C PF15706.3 NM_175432.3_3 - 5e-36 122.2 0.0 1.2e-35 121.0 0.0 1.7 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term PrmA PF06325.11 NM_177101.5_3 - 1.2e-10 41.2 0.1 1.8e-10 40.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.7 NM_177101.5_3 - 5.5e-08 32.6 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.12 NM_177101.5_3 - 7.8e-06 25.4 0.0 1.2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.14 NM_177101.5_3 - 0.00077 19.1 0.0 0.0013 18.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.4 NM_177101.5_3 - 0.0041 16.9 0.0 0.0095 15.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_177101.5_3 - 0.015 15.9 0.0 0.025 15.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.4 NM_177101.5_3 - 0.17 11.5 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TRM PF02005.14 NM_177101.5_3 - 0.18 10.8 0.0 0.25 10.3 0.0 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Fz PF01392.20 NM_011356.4_2 - 8e-29 100.5 4.0 8e-29 100.5 4.0 1.9 2 0 0 2 2 2 1 Fz domain NTR PF01759.19 NM_011356.4_2 - 1.9e-20 72.5 1.6 3.7e-20 71.6 1.6 1.5 1 0 0 1 1 1 1 UNC-6/NTR/C345C module stn_TNFRSF12A PF12191.6 NM_009259.5_1 - 0.048 13.8 0.2 0.13 12.4 0.2 1.7 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain R3H-assoc PF13902.4 NM_177994.4_2 - 1.4e-34 119.2 0.1 2e-34 118.7 0.1 1.2 1 0 0 1 1 1 1 R3H-associated N-terminal domain R3H PF01424.20 NM_177994.4_2 - 2e-06 27.6 0.0 3.8e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 R3H domain PRT_C PF08372.8 NM_177994.4_2 - 1.7 8.2 4.6 30 4.2 2.7 2.3 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal Btz PF09405.8 NM_138660.2_3 - 1.3e-23 83.6 6.3 1.3e-23 83.6 6.3 2.4 1 1 1 2 2 2 1 CASC3/Barentsz eIF4AIII binding TIG PF01833.22 NM_138674.2_1 - 4.2e-180 584.2 102.4 1.1e-16 60.5 1.0 15.4 14 0 0 14 14 14 14 IPT/TIG domain G8 PF10162.7 NM_138674.2_1 - 6.3e-70 232.8 0.2 5.4e-35 120.0 0.1 3.1 2 0 0 2 2 2 2 G8 domain Beta_helix PF13229.4 NM_138674.2_1 - 2e-12 47.1 29.4 1e-07 31.8 7.2 6.2 4 1 1 5 5 5 3 Right handed beta helix region PA14 PF07691.10 NM_138674.2_1 - 9.1e-11 41.6 0.3 5.6e-10 39.1 0.5 2.3 2 0 0 2 2 2 1 PA14 domain NosD PF05048.11 NM_138674.2_1 - 0.0059 15.8 5.6 0.65 9.1 0.6 3.5 2 1 1 3 3 3 2 Periplasmic copper-binding protein (NosD) INT_SG_DDX_CT_C PF15300.4 NM_172779.4_2 - 6.3e-31 105.8 3.1 1.3e-30 104.9 3.1 1.5 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus VWA_2 PF13519.4 NM_172779.4_2 - 4.6e-21 75.4 0.0 8.7e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 NM_172779.4_2 - 0.00063 19.9 0.0 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Reprolysin PF01421.17 NM_010085.3_1 - 3.3e-46 157.6 2.3 3.3e-46 157.6 2.3 3.1 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_010085.3_1 - 1.1e-33 115.9 10.4 1.1e-33 115.9 10.4 3.2 3 1 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 NM_010085.3_1 - 5e-21 75.2 28.3 5e-21 75.2 28.3 4.7 4 1 0 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.17 NM_010085.3_1 - 1e-16 61.3 0.1 1.8e-16 60.5 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_010085.3_1 - 2.6e-13 50.4 1.0 5.7e-13 49.3 1.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 NM_010085.3_1 - 2.2e-12 47.4 0.2 4.9e-12 46.3 0.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_010085.3_1 - 1.9e-09 37.6 2.6 7.6e-09 35.6 2.6 2.0 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_010085.3_1 - 4.6e-07 29.5 0.1 8.6e-07 28.7 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 NM_010085.3_1 - 0.033 13.9 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Matrixin Peptidase_M57 PF12388.6 NM_010085.3_1 - 0.047 13.2 0.1 0.1 12.0 0.1 1.5 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Hist_rich_Ca-bd PF10529.7 NM_010473.2_3 - 6.6e-05 22.8 8.7 6.6e-05 22.8 8.7 24.1 23 3 1 24 24 24 10 Histidine-rich Calcium-binding repeat region EpoR_lig-bind PF09067.8 NM_011169.5_2 - 1.1e-23 83.2 0.0 1.1e-23 83.2 0.0 3.2 3 0 0 3 3 3 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.8 NM_011169.5_2 - 2.4e-07 30.9 0.2 5.8e-07 29.7 0.2 1.7 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.19 NM_011169.5_2 - 1.1e-05 25.5 3.2 0.0015 18.7 0.3 2.5 2 0 0 2 2 2 2 Fibronectin type III domain SNF2_N PF00176.21 NM_001285945.1_1 - 3.3e-29 101.6 0.0 5.5e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 NM_001285945.1_1 - 2e-14 53.8 0.1 8.5e-14 51.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HNH PF01844.21 NM_001285945.1_1 - 1.2e-09 38.0 1.0 3.2e-09 36.7 0.1 2.2 2 0 0 2 2 2 1 HNH endonuclease ResIII PF04851.13 NM_001285945.1_1 - 7.8e-08 32.4 0.0 8.2e-07 29.0 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit zf-RanBP PF00641.16 NM_001285945.1_1 - 0.00056 19.0 1.0 0.00056 19.0 1.0 2.8 4 0 0 4 4 4 1 Zn-finger in Ran binding protein and others Flavi_DEAD PF07652.12 NM_001285945.1_1 - 0.0017 18.2 0.0 0.0031 17.4 0.0 1.3 1 0 0 1 1 1 1 Flavivirus DEAD domain DEAD PF00270.27 NM_001285945.1_1 - 0.0029 17.3 0.0 0.0051 16.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.3 NM_001285945.1_1 - 0.059 12.4 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase HNH_5 PF14279.4 NM_001285945.1_1 - 0.1 12.3 0.1 0.1 12.3 0.1 1.9 2 0 0 2 2 2 0 HNH endonuclease HELP PF03451.12 NM_001162996.1_2 - 1.5e-29 101.6 0.0 2.6e-29 100.7 0.0 1.5 1 0 0 1 1 1 1 HELP motif WD40 PF00400.30 NM_001162996.1_2 - 2.3e-26 91.4 38.2 0.0034 18.1 0.5 11.4 11 1 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001162996.1_2 - 5.2e-10 39.3 0.2 0.084 13.1 0.0 5.8 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 NM_001162996.1_2 - 0.014 14.2 0.0 0.043 12.6 0.0 1.8 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CPSF_A PF03178.13 NM_001162996.1_2 - 0.12 11.5 0.0 2.2 7.4 0.0 2.7 2 1 1 3 3 3 0 CPSF A subunit region PRMT5 PF05185.14 NM_001313907.1_2 - 4.3e-180 599.5 0.2 5.4e-180 599.1 0.2 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase SAMBD PF16950.3 NM_001313907.1_2 - 2.4e-103 345.7 1.0 1.8e-78 264.0 0.2 2.1 1 1 1 2 2 2 2 SAM-binding_domain Met_10 PF02475.14 NM_001313907.1_2 - 0.0075 15.9 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.12 NM_001313907.1_2 - 0.0096 15.3 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain 7tm_1 PF00001.19 NM_053244.5_3 - 5.5e-47 160.1 8.4 7.9e-47 159.6 8.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_053244.5_3 - 2e-05 24.4 1.7 2.9e-05 23.8 1.7 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 NM_053244.5_3 - 8.5e-05 21.9 2.2 0.00014 21.2 2.2 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_053244.5_3 - 0.048 12.8 4.6 0.072 12.3 4.6 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx BCL_N PF04714.11 NM_009745.2_1 - 7.9e-28 96.1 6.6 1.4e-27 95.4 6.6 1.4 1 0 0 1 1 1 1 BCL7, N-terminal conserver region 7tm_4 PF13853.4 NM_001011741.2_1 - 5.9e-49 167.1 8.0 8.2e-49 166.7 8.0 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011741.2_1 - 1.6e-23 83.2 9.9 3.6e-23 82.0 9.9 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011741.2_1 - 6.7e-05 22.3 7.2 0.00013 21.3 7.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx NRN1 PF15056.4 NM_153529.2_2 - 1.1e-37 127.9 1.5 1.7e-37 127.3 1.5 1.3 1 0 0 1 1 1 1 Neuritin protein family BTD PF09270.8 NM_001080928.1_1 - 2.3e-74 248.6 0.0 3.6e-74 248.0 0.0 1.3 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.9 NM_001080928.1_1 - 1.3e-50 171.8 0.9 2.5e-50 170.9 0.9 1.5 1 0 0 1 1 1 1 LAG1, DNA binding TIG PF01833.22 NM_001080928.1_1 - 0.0038 17.1 0.0 0.01 15.7 0.0 1.7 1 0 0 1 1 1 1 IPT/TIG domain V1R PF03402.12 NM_134212.1_1 - 1.3e-35 123.2 8.1 1.7e-35 122.8 8.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_134212.1_1 - 5.8e-07 28.8 16.0 7.9e-07 28.3 16.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Mago-bind PF09282.8 NM_001170869.2_1 - 1.2e-13 50.5 1.8 2.5e-13 49.5 1.8 1.6 1 0 0 1 1 1 1 Mago binding Nif11 PF07862.9 NM_001170869.2_1 - 0.16 12.2 1.4 0.29 11.3 1.4 1.4 1 0 0 1 1 1 0 Nitrogen fixation protein of unknown function Cobalamin_bind PF01122.17 NM_008118.3_2 - 1.5e-106 355.7 0.0 2e-106 355.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein DUF4430 PF14478.4 NM_008118.3_2 - 1.7e-05 25.2 0.1 2.9e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) Gemini_AL3 PF01407.15 NM_008118.3_2 - 0.12 12.1 0.1 0.43 10.3 0.1 2.0 2 0 0 2 2 2 0 Geminivirus AL3 protein ILEI PF15711.3 NM_031997.4_2 - 2.3e-33 114.4 0.0 3.8e-21 75.2 0.0 2.7 2 0 0 2 2 2 2 Interleukin-like EMT inducer G8 PF10162.7 NM_031997.4_2 - 1.8e-28 98.9 0.0 3.3e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 G8 domain JAB PF01398.19 NM_013715.2_3 - 1.2e-33 115.5 0.0 2.1e-33 114.7 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 NM_013715.2_3 - 0.00036 20.2 0.0 0.00063 19.4 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.11 NM_013715.2_3 - 0.012 15.6 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) COX14 PF14880.4 NM_183256.3_3 - 1.8e-10 40.4 0.1 3e-10 39.7 0.1 1.3 1 0 0 1 1 1 1 Cytochrome oxidase c assembly Antimicrobial_4 PF08024.9 NM_183256.3_3 - 0.48 10.4 3.7 0.79 9.7 3.7 1.3 1 0 0 1 1 1 0 Ant antimicrobial peptide Guanylate_kin PF00625.19 NM_001290402.1_3 - 4.9e-65 218.5 0.5 7.2e-65 217.9 0.5 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 NM_001290402.1_3 - 4.4e-62 206.3 9.4 1.5e-20 73.2 0.3 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_assoc PF10600.7 NM_001290402.1_3 - 8.6e-28 96.8 3.1 2.3e-27 95.5 3.1 1.8 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 NM_001290402.1_3 - 1.9e-16 60.0 1.1 0.0001 22.4 0.0 3.3 3 0 0 3 3 3 3 PDZ domain SH3_1 PF00018.26 NM_001290402.1_3 - 3e-08 33.0 0.0 1.1e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 NM_001290402.1_3 - 2e-07 30.4 0.0 5.6e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_001290402.1_3 - 0.0074 16.0 0.0 0.022 14.5 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain Yippee-Mis18 PF03226.12 NM_026875.2_2 - 3.7e-12 46.2 0.2 5.9e-12 45.6 0.2 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.6 NM_026875.2_2 - 0.1 12.7 0.4 0.2 11.8 0.4 1.4 1 1 0 1 1 1 0 C-terminal domain of RIG-I Yippee-Mis18 PF03226.12 NM_027166.5_2 - 9.8e-13 48.1 0.1 1.9e-12 47.2 0.1 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.16 NM_027166.5_2 - 0.032 14.1 0.3 0.065 13.2 0.0 1.5 2 0 0 2 2 2 0 SelR domain CBFB_NFYA PF02045.13 NM_001110832.1_3 - 1e-26 93.3 8.9 2e-26 92.3 8.9 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B K_channel_TID PF07941.9 NM_001110832.1_3 - 0.13 12.6 4.1 0.39 11.1 4.1 1.9 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain PET PF06297.12 NM_001034864.3_1 - 2e-38 130.4 1.4 3.8e-38 129.5 1.4 1.5 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 NM_001034864.3_1 - 1.1e-26 92.7 57.5 1e-13 51.2 9.4 4.6 4 2 0 4 4 4 3 LIM domain SET PF00856.26 NM_178391.4_1 - 1e-19 71.4 0.0 3.2e-18 66.6 0.0 2.1 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.14 NM_178391.4_1 - 3.1e-13 50.2 7.8 4.4e-13 49.7 2.6 2.3 2 0 0 2 2 2 1 Pre-SET motif Arm_2 PF04826.11 NM_001098222.1_1 - 6e-90 301.0 4.9 8.9e-90 300.4 4.9 1.2 1 0 0 1 1 1 1 Armadillo-like Insulin PF00049.16 NM_010512.5_2 - 1.6e-12 48.1 3.9 1.1e-10 42.2 3.9 2.7 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family EF-hand_4 PF12763.5 NM_001122832.1_2 - 3.9e-40 135.9 0.0 1.4e-22 79.5 0.0 3.7 4 0 0 4 4 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.30 NM_001122832.1_2 - 2.6e-14 51.5 0.6 0.0036 16.6 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_001122832.1_2 - 1.3e-08 34.0 1.6 0.47 10.4 0.2 4.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.4 NM_001122832.1_2 - 3.7e-07 30.4 1.1 0.053 13.9 0.1 3.9 2 2 1 3 3 3 2 EF-hand domain pair EzrA PF06160.10 NM_001122832.1_2 - 4.9e-05 21.6 34.0 0.00012 20.4 34.0 1.5 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA Macoilin PF09726.7 NM_001122832.1_2 - 0.0001 20.9 12.2 0.00015 20.4 12.2 1.2 1 0 0 1 1 1 1 Transmembrane protein EF-hand_8 PF13833.4 NM_001122832.1_2 - 0.0018 17.8 1.0 0.31 10.7 0.2 3.5 4 0 0 4 4 4 1 EF-hand domain pair CALCOCO1 PF07888.9 NM_001122832.1_2 - 0.0065 15.0 30.4 0.0088 14.5 30.4 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like ERM PF00769.17 NM_001122832.1_2 - 0.0073 16.0 31.3 0.014 15.1 31.3 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family ATG16 PF08614.9 NM_001122832.1_2 - 0.0076 16.3 44.9 0.2 11.7 30.1 2.4 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) KASH_CCD PF14662.4 NM_001122832.1_2 - 0.008 15.9 8.9 0.008 15.9 8.9 2.1 1 1 1 2 2 1 1 Coiled-coil region of CCDC155 or KASH IFT57 PF10498.7 NM_001122832.1_2 - 0.0092 14.9 26.0 0.016 14.1 26.0 1.3 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 MscS_porin PF12795.5 NM_001122832.1_2 - 0.011 15.2 53.1 0.025 14.0 22.2 2.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Reo_sigmaC PF04582.10 NM_001122832.1_2 - 0.012 14.8 14.9 0.025 13.8 11.4 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Tropomyosin PF00261.18 NM_001122832.1_2 - 0.016 14.5 33.3 0.008 15.4 18.8 2.1 1 1 1 2 2 2 0 Tropomyosin EF-hand_5 PF13202.4 NM_001122832.1_2 - 0.033 13.6 2.2 0.44 10.0 0.1 2.7 2 0 0 2 2 2 0 EF hand Spc7 PF08317.9 NM_001122832.1_2 - 0.052 12.3 40.6 0.42 9.3 15.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF16 PF01519.14 NM_001122832.1_2 - 0.054 13.9 25.3 0.2 12.0 9.3 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF4201 PF13870.4 NM_001122832.1_2 - 0.075 12.5 33.9 0.041 13.4 17.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) EF-hand_9 PF14658.4 NM_001122832.1_2 - 0.1 12.8 0.0 0.44 10.8 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain Fez1 PF06818.13 NM_001122832.1_2 - 0.1 12.9 35.9 0.57 10.5 20.9 2.1 1 1 1 2 2 2 0 Fez1 Med30 PF11315.6 NM_001122832.1_2 - 0.11 12.7 19.6 0.11 12.6 18.1 1.7 1 1 1 2 2 2 0 Mediator complex subunit 30 Atg14 PF10186.7 NM_001122832.1_2 - 0.12 11.3 37.4 0.38 9.7 8.0 2.4 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 MPS2 PF17060.3 NM_001122832.1_2 - 0.14 11.3 16.6 0.22 10.6 16.6 1.3 1 0 0 1 1 1 0 Monopolar spindle protein 2 Transposase_22 PF02994.12 NM_001122832.1_2 - 0.15 10.7 15.0 0.24 10.1 15.0 1.2 1 0 0 1 1 1 0 L1 transposable element WEMBL PF05701.9 NM_001122832.1_2 - 0.15 10.5 29.0 0.21 10.1 29.0 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light DUF4763 PF15960.3 NM_001122832.1_2 - 0.16 11.1 38.1 0.055 12.6 7.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) DUF745 PF05335.11 NM_001122832.1_2 - 0.17 11.5 28.7 0.91 9.1 3.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) HrpB7 PF09486.8 NM_001122832.1_2 - 0.19 11.9 32.0 0.89 9.8 19.9 3.0 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) BicD PF09730.7 NM_001122832.1_2 - 0.2 9.9 28.1 0.28 9.4 28.1 1.0 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D HMMR_N PF15905.3 NM_001122832.1_2 - 0.3 10.4 38.3 0.96 8.7 22.5 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal FliJ PF02050.14 NM_001122832.1_2 - 0.35 11.0 41.1 0.2 11.8 20.6 3.2 1 1 2 3 3 3 0 Flagellar FliJ protein TMF_DNA_bd PF12329.6 NM_001122832.1_2 - 0.72 9.8 41.7 0.46 10.4 16.0 3.6 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF3584 PF12128.6 NM_001122832.1_2 - 0.8 7.0 32.1 1.3 6.3 32.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3377 PF11857.6 NM_001122832.1_2 - 0.8 9.5 5.3 2.6 7.9 5.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Leu_zip PF15294.4 NM_001122832.1_2 - 0.8 9.0 29.4 0.25 10.7 26.0 1.6 1 1 0 1 1 1 0 Leucine zipper Mucin15 PF15672.3 NM_001122832.1_2 - 0.93 8.8 4.3 2 7.7 4.3 1.5 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 Prominin PF05478.9 NM_001122832.1_2 - 1.8 6.3 25.2 9.9 3.8 22.9 2.0 1 1 0 1 1 1 0 Prominin CCDC144C PF14915.4 NM_001122832.1_2 - 2.1 7.3 40.7 0.099 11.6 16.3 2.1 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region TPR_MLP1_2 PF07926.10 NM_001122832.1_2 - 2.5 8.0 43.4 1.1 9.2 18.3 3.0 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF948 PF06103.9 NM_001122832.1_2 - 2.9 8.1 14.5 3.5 7.8 0.4 3.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) AAA_13 PF13166.4 NM_001122832.1_2 - 3.2 6.2 25.1 18 3.6 25.2 1.8 1 1 0 1 1 1 0 AAA domain ADIP PF11559.6 NM_001122832.1_2 - 3.6 7.5 41.5 0.28 11.1 17.8 2.8 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding MAD PF05557.11 NM_001122832.1_2 - 3.7 5.7 40.1 7.9 4.5 39.8 1.5 1 1 0 1 1 1 0 Mitotic checkpoint protein IncA PF04156.12 NM_001122832.1_2 - 4 7.0 59.6 0.017 14.8 26.7 3.1 2 1 1 3 3 2 0 IncA protein CENP-F_leu_zip PF10473.7 NM_001122832.1_2 - 4.6 7.1 40.9 13 5.6 18.2 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6 PF04111.10 NM_001122832.1_2 - 6.2 6.0 41.0 7.2 5.8 27.2 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 Filament PF00038.19 NM_001122832.1_2 - 6.7 6.1 35.7 1.5 8.2 10.7 2.3 1 1 1 2 2 2 0 Intermediate filament protein Gly_acyl_tr_N PF06021.9 NM_001167907.1_2 - 1.1e-86 290.0 0.2 1.5e-86 289.6 0.2 1.2 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.8 NM_001167907.1_2 - 8.3e-43 144.4 1.6 1e-42 144.1 0.4 1.8 2 0 0 2 2 2 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region MFS_2 PF13347.4 NM_001033219.3_1 - 7.8e-08 31.1 1.0 7.8e-08 31.1 1.0 3.0 3 1 0 3 3 3 1 MFS/sugar transport protein Pkinase PF00069.23 NM_183294.2_2 - 8.1e-83 277.7 0.0 1e-82 277.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_183294.2_2 - 2.5e-33 115.3 0.0 5.9e-33 114.1 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_183294.2_2 - 0.02 14.0 0.0 0.68 9.1 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Seadorna_VP7 PF07387.9 NM_183294.2_2 - 0.071 12.0 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Keratin_B2_2 PF13885.4 NM_001126323.1_1 - 1.1e-07 31.6 139.3 5.3e-05 22.9 37.7 4.3 3 1 0 3 3 3 2 Keratin, high sulfur B2 protein UCH PF00443.27 NM_001168373.2_3 - 1.7e-76 257.0 0.0 2.4e-76 256.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP19_linker PF16602.3 NM_001168373.2_3 - 5.3e-54 181.8 7.5 5.3e-54 181.8 7.5 2.4 2 0 0 2 2 2 1 Linker region of USP19 deubiquitinase UCH_1 PF13423.4 NM_001168373.2_3 - 2e-19 70.2 0.0 7.9e-09 35.4 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase CS PF04969.14 NM_001168373.2_3 - 2e-17 63.8 0.0 4.2e-13 50.0 0.0 2.5 2 0 0 2 2 2 2 CS domain zf-MYND PF01753.16 NM_001168373.2_3 - 2.3e-07 30.6 16.5 2.3e-07 30.6 16.5 3.1 5 0 0 5 5 5 1 MYND finger USP7_C2 PF14533.4 NM_001168373.2_3 - 0.013 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal Aa_trans PF01490.16 NM_001164802.1_1 - 1.1e-54 185.6 30.0 1.4e-54 185.3 30.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ABC2_membrane_3 PF12698.5 NM_001166557.1_1 - 4.1e-27 95.1 12.4 6e-27 94.5 12.4 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein DASH_Dam1 PF08653.8 NM_001166557.1_1 - 7.9 6.2 7.8 12 5.7 0.4 3.5 4 0 0 4 4 4 0 DASH complex subunit Dam1 GDPD PF03009.15 NM_001305941.1_1 - 1.9e-23 83.4 0.0 2e-22 80.0 0.0 2.0 1 1 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.4 NM_001305941.1_1 - 0.0019 18.5 0.1 0.0045 17.4 0.1 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family dNK PF01712.17 NM_007832.4_1 - 1.4e-75 253.5 0.7 1.8e-75 253.2 0.7 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.4 NM_007832.4_1 - 0.031 14.7 0.0 0.4 11.1 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.4 NM_007832.4_1 - 0.043 13.9 0.0 0.071 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.15 NM_007832.4_1 - 0.071 12.6 0.0 0.46 10.0 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase MFS_1 PF07690.14 NM_001170638.1_1 - 2.2e-48 164.9 32.1 1.5e-46 158.8 29.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Arm PF00514.21 NM_001001334.2_1 - 8.9e-42 139.8 22.5 8e-08 31.9 0.1 9.0 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 NM_001001334.2_1 - 3.6e-15 56.0 8.4 7.1e-05 23.0 1.2 5.2 3 2 2 5 5 5 5 HEAT repeats HEAT PF02985.20 NM_001001334.2_1 - 1.2e-14 53.0 13.2 0.0013 18.6 0.0 7.4 8 0 0 8 8 7 4 HEAT repeat Cnd1 PF12717.5 NM_001001334.2_1 - 2.2e-14 53.6 2.0 7.7e-06 25.9 0.2 4.6 2 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 NM_001001334.2_1 - 3.3e-12 46.5 16.3 0.0043 17.4 0.0 6.5 6 2 2 8 8 7 4 HEAT-like repeat DNA_alkylation PF08713.9 NM_001001334.2_1 - 1.2e-08 34.8 0.1 0.025 14.2 0.0 4.4 2 1 1 5 5 5 2 DNA alkylation repair enzyme Adaptin_N PF01602.18 NM_001001334.2_1 - 5.4e-08 31.7 5.3 0.0025 16.3 1.1 3.6 1 1 2 3 3 3 2 Adaptin N terminal region CHASE6_C PF17150.2 NM_001001334.2_1 - 1.4e-06 28.7 4.5 6.6 7.3 0.0 7.0 6 1 0 7 7 7 1 C-terminal domain of two-partite extracellular sensor domain Atx10homo_assoc PF09759.7 NM_001001334.2_1 - 0.00011 22.1 0.6 0.65 10.0 0.1 4.5 4 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain Proteasom_PSMB PF10508.7 NM_001001334.2_1 - 0.00012 20.6 5.4 0.001 17.5 0.7 2.9 1 1 0 2 2 2 1 Proteasome non-ATPase 26S subunit V-ATPase_H_C PF11698.6 NM_001001334.2_1 - 0.0002 21.3 1.5 0.48 10.4 0.1 3.8 3 1 0 4 4 4 1 V-ATPase subunit H NopRA1 PF16201.3 NM_001001334.2_1 - 0.00079 18.9 0.3 0.16 11.4 0.0 3.4 3 2 0 4 4 3 1 Nucleolar pre-ribosomal-associated protein 1 CLASP_N PF12348.6 NM_001001334.2_1 - 0.0021 17.6 0.2 1.8 7.9 0.0 3.2 2 1 2 4 4 4 1 CLASP N terminal RTP1_C1 PF10363.7 NM_001001334.2_1 - 0.0069 16.4 0.5 0.033 14.2 0.2 2.3 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.5 NM_001001334.2_1 - 0.0084 16.5 0.1 0.23 11.9 0.1 3.1 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region MMS19_C PF12460.6 NM_001001334.2_1 - 0.0085 15.1 1.6 0.088 11.8 0.3 2.7 2 0 0 2 2 2 1 RNAPII transcription regulator C-terminal Arm_2 PF04826.11 NM_001001334.2_1 - 0.014 14.7 1.4 3.9 6.7 0.2 3.7 1 1 3 4 4 4 0 Armadillo-like Rcd1 PF04078.11 NM_001001334.2_1 - 0.015 14.5 0.2 0.076 12.2 0.2 2.1 2 1 1 3 3 3 0 Cell differentiation family, Rcd1-like DUF3361 PF11841.6 NM_001001334.2_1 - 0.043 13.6 4.0 0.5 10.2 0.7 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF3361) HEAT_PBS PF03130.14 NM_001001334.2_1 - 0.048 14.2 12.1 1.1 10.0 0.3 5.1 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat API5 PF05918.9 NM_001001334.2_1 - 0.19 10.4 4.0 2.9 6.5 1.3 2.9 2 1 1 3 3 3 0 Apoptosis inhibitory protein 5 (API5) zf-HC5HC2H_2 PF13832.4 NM_029404.3_1 - 1.3e-26 92.7 1.6 1.3e-26 92.7 1.6 3.7 4 0 0 4 4 4 1 PHD-zinc-finger like domain PHD PF00628.27 NM_029404.3_1 - 9e-18 63.8 45.8 6.2e-10 38.7 8.5 4.3 5 0 0 5 5 5 3 PHD-finger zf-HC5HC2H PF13771.4 NM_029404.3_1 - 4.1e-17 62.1 1.4 4.1e-17 62.1 1.4 4.1 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.4 NM_029404.3_1 - 9.5e-06 24.9 23.2 2.4e-05 23.7 6.2 4.7 3 1 0 3 3 3 2 PHD-finger Prok-RING_1 PF14446.4 NM_029404.3_1 - 0.15 11.9 25.1 0.039 13.7 4.0 3.7 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 DUF3915 PF13054.4 NM_029404.3_1 - 0.61 9.9 3.1 2.2 8.2 3.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) ANAPC10 PF03256.14 NM_026904.2_2 - 3.3e-80 268.0 0.1 4.5e-80 267.5 0.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.23 NM_026904.2_2 - 0.0016 18.4 0.1 0.0025 17.8 0.1 1.2 1 0 0 1 1 1 1 F5/8 type C domain PITH PF06201.11 NM_026904.2_2 - 0.066 13.3 0.1 0.17 11.9 0.1 1.6 1 1 0 1 1 1 0 PITH domain Ion_trans PF00520.29 NM_183179.1_1 - 7.9e-37 126.7 1.3 1.3e-36 125.9 1.3 1.3 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_183179.1_1 - 4.2e-20 71.8 0.0 1.1e-19 70.4 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_183179.1_1 - 2.3e-13 49.8 3.9 5.4e-13 48.6 3.9 1.6 1 0 0 1 1 1 1 Ion channel PKD_channel PF08016.10 NM_183179.1_1 - 0.00028 19.6 0.4 0.0005 18.7 0.4 1.3 1 0 0 1 1 1 1 Polycystin cation channel DUF4672 PF15716.3 NM_183179.1_2 - 0.8 9.2 4.2 1.9 7.9 4.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) Beta-Casp PF10996.6 NM_028020.3_1 - 7e-26 90.6 0.0 2.5e-25 88.8 0.0 2.0 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_6 PF16661.3 NM_028020.3_1 - 8.1e-23 80.7 0.0 1.6e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.10 NM_028020.3_1 - 5.2e-17 61.4 0.0 1e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.25 NM_028020.3_1 - 1.4e-10 41.4 0.0 6e-08 32.8 0.0 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 NM_028020.3_1 - 5.1e-08 32.5 0.7 1.3e-07 31.2 0.1 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.4 NM_028020.3_1 - 9.1e-05 22.3 0.0 0.0012 18.6 0.0 2.5 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.3 NM_028020.3_1 - 0.00047 19.3 0.0 0.0013 17.9 0.0 1.6 1 1 0 1 1 1 1 Putative beta-lactamase-like family zf-H2C2_2 PF13465.4 NM_001199048.1_1 - 5.1e-79 257.3 120.2 1.8e-08 34.3 2.7 13.2 12 0 0 12 12 12 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001199048.1_1 - 2.1e-44 147.4 152.1 2.5e-06 27.5 2.8 13.0 12 0 0 12 12 12 11 Zinc finger, C2H2 type KRAB PF01352.25 NM_001199048.1_1 - 9.6e-22 76.3 2.1 2e-21 75.2 2.1 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001199048.1_1 - 1.9e-16 59.2 137.4 0.018 15.7 1.8 13.0 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001199048.1_1 - 2.4e-09 36.6 94.5 0.0023 17.5 1.0 12.9 12 0 0 12 12 12 8 zinc-finger C2H2-type zf-met PF12874.5 NM_001199048.1_1 - 0.013 15.7 2.5 0.013 15.7 2.5 12.3 12 0 0 12 12 12 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 NM_001199048.1_2 - 1.2e-15 57.0 17.2 1.2e-07 31.7 0.3 3.8 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001199048.1_2 - 2.1e-06 27.7 1.6 2.1e-06 27.7 1.6 4.4 5 0 0 5 5 5 1 Zinc finger, C2H2 type zf-H2C2_5 PF13909.4 NM_001199048.1_2 - 0.0092 15.6 1.1 0.0092 15.6 1.1 2.9 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.4 NM_001199048.1_2 - 0.015 15.9 1.2 0.015 15.9 1.2 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001199048.1_2 - 0.08 12.8 5.3 0.46 10.4 0.4 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Viral_Rep PF02407.14 NM_001199048.1_2 - 0.15 12.2 1.7 11 6.2 0.0 3.2 3 0 0 3 3 3 0 Putative viral replication protein Zn-ribbon_8 PF09723.8 NM_001199048.1_2 - 4.2 7.4 9.1 12 6.0 4.8 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-H2C2_2 PF13465.4 NM_001199048.1_3 - 4.4e-06 26.8 15.5 0.00017 21.8 0.7 4.0 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001199048.1_3 - 6.2e-05 23.1 17.5 0.027 14.8 1.3 4.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001199048.1_3 - 6.9 7.7 15.2 1.2 10.0 1.2 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger EF-hand_1 PF00036.30 NM_001085387.2_2 - 1.5e-08 33.5 4.5 2e-05 23.7 0.2 3.6 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.4 NM_001085387.2_2 - 2.2e-08 33.3 5.4 1.1e-05 24.9 0.5 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 NM_001085387.2_2 - 2.7e-08 34.0 1.7 1.6e-06 28.3 0.8 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 NM_001085387.2_2 - 4.4e-08 32.6 1.6 0.0039 16.8 0.1 3.5 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 NM_001085387.2_2 - 0.0004 19.7 0.4 0.0004 19.7 0.4 2.7 3 0 0 3 3 3 1 EF hand NCD2 PF04905.11 NM_008667.3_1 - 2.3e-64 216.0 0.5 4.2e-64 215.1 0.5 1.4 1 0 0 1 1 1 1 NAB conserved region 2 (NCD2) Nab1 PF04902.10 NM_008667.3_1 - 7.2e-51 173.0 0.2 1.1e-50 172.5 0.2 1.3 1 0 0 1 1 1 1 Conserved region in Nab1 NCD1 PF04904.11 NM_008667.3_1 - 9e-41 137.6 0.0 1.5e-40 136.9 0.0 1.3 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) Glyoxalase PF00903.23 NM_001113560.1_1 - 4.3e-23 81.8 0.0 5.4e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.4 NM_001113560.1_1 - 2.4e-06 27.7 0.0 6.6e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 7tm_1 PF00001.19 NM_001285484.1_3 - 4.5e-74 248.9 14.0 6.8e-74 248.3 14.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001285484.1_3 - 6.2e-10 38.8 8.5 1.5e-09 37.5 8.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_001285484.1_3 - 1.9e-05 24.4 11.9 0.0006 19.5 9.1 2.4 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 NM_001285484.1_3 - 0.4 9.8 16.8 0.046 12.9 11.2 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Metallophos PF00149.26 NM_017374.3_3 - 2.1e-34 119.7 0.5 3.1e-34 119.1 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 NM_017374.3_3 - 0.013 15.8 0.3 0.027 14.8 0.3 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain DUF3585 PF12130.6 NM_001114596.1_1 - 2.3e-40 137.8 26.8 4.3e-40 136.9 26.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) CH PF00307.29 NM_001114596.1_1 - 1.4e-21 76.6 0.0 2.8e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain NT-C2 PF10358.7 NM_001114596.1_1 - 6.1e-21 74.5 0.0 9.7e-21 73.9 0.0 1.3 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins CAMSAP_CH PF11971.6 NM_001114596.1_1 - 0.00027 20.6 0.0 0.00051 19.7 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain Glyco_transf_11 PF01531.14 NM_001271578.1_1 - 8.1e-143 474.9 0.0 1e-142 474.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 11 DCX PF03607.15 NM_010025.2_2 - 1.6e-41 140.1 0.1 3.5e-21 74.9 0.0 2.7 2 0 0 2 2 2 2 Doublecortin DUF2457 PF10446.7 NM_010025.2_2 - 2.1 7.3 4.5 3.3 6.7 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) bZIP_1 PF00170.19 NM_001253686.1_1 - 0.78 9.7 3.6 1.6 8.7 3.6 1.4 1 0 0 1 1 1 0 bZIP transcription factor Mitofilin PF09731.7 NM_001253686.1_2 - 3.5e-207 690.0 32.6 4.2e-207 689.7 32.6 1.0 1 0 0 1 1 1 1 Mitochondrial inner membrane protein F-box-like PF12937.5 NM_013911.3_2 - 5.1e-13 48.5 4.9 1.2e-12 47.4 4.9 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_013911.3_2 - 2.1e-11 43.3 5.3 2.1e-11 43.3 5.3 2.0 2 0 0 2 2 2 1 F-box domain IL17 PF06083.9 NM_019508.1_2 - 1.4e-26 92.6 2.4 2.1e-26 92.1 2.4 1.2 1 0 0 1 1 1 1 Interleukin-17 RUN PF02759.17 NM_001289775.1_2 - 1.2e-31 109.4 0.4 4.8e-31 107.4 0.0 2.0 2 0 0 2 2 2 1 RUN domain Trimer_CC PF08954.9 NM_001289775.1_2 - 0.00074 18.9 1.4 0.19 11.2 0.0 2.7 2 0 0 2 2 2 2 Trimerisation motif DUF2344 PF10105.7 NM_001289775.1_2 - 0.49 10.1 3.1 1 9.0 3.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) WD40 PF00400.30 NM_080848.2_2 - 6e-59 194.5 19.9 1.8e-09 37.9 0.2 8.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_080848.2_2 - 8.5e-24 83.5 1.7 0.00016 21.8 0.1 6.2 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_080848.2_2 - 2.3e-12 46.2 4.1 0.0049 15.4 0.2 4.4 1 1 3 4 4 4 4 Nucleoporin Nup120/160 eIF2A PF08662.9 NM_080848.2_2 - 1.1e-09 38.3 0.3 9.2e-05 22.3 0.0 3.3 1 1 4 5 5 5 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.3 NM_080848.2_2 - 8.7e-05 21.8 0.1 0.021 14.0 0.0 2.8 1 1 3 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.3 NM_080848.2_2 - 0.00016 20.6 4.5 0.19 10.6 0.6 3.6 1 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.3 NM_080848.2_2 - 0.00061 18.7 1.1 7.4 5.3 0.0 3.9 1 1 2 4 4 4 3 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.6 NM_080848.2_2 - 0.008 14.4 0.0 0.1 10.7 0.0 2.0 1 1 1 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz TRPM_tetra PF16519.3 NM_177341.4_1 - 3.7e-24 84.4 5.4 9.6e-24 83.1 5.4 1.8 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.29 NM_177341.4_1 - 2.7e-18 66.0 17.2 4.6e-18 65.2 17.2 1.3 1 0 0 1 1 1 1 Ion transport protein DUF3552 PF12072.6 NM_177341.4_1 - 0.03 13.6 4.3 0.062 12.6 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Reo_sigmaC PF04582.10 NM_177341.4_1 - 0.11 11.7 0.9 0.2 10.9 0.9 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DegS PF05384.9 NM_177341.4_1 - 4.4 6.6 8.6 0.43 9.9 2.2 2.4 3 0 0 3 3 3 0 Sensor protein DegS SMK-1 PF04802.13 NM_001160214.1_2 - 7.4e-81 270.5 6.2 1.4e-80 269.6 6.2 1.5 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.21 NM_001160214.1_2 - 0.0034 17.2 0.0 0.0068 16.2 0.0 1.5 1 0 0 1 1 1 1 WH1 domain Ran_BP1 PF00638.16 NM_001160214.1_2 - 0.035 14.2 0.0 0.087 13.0 0.0 1.6 1 0 0 1 1 1 0 RanBP1 domain NUDIX PF00293.26 NM_177197.4_3 - 2.4e-16 59.8 0.0 3.4e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain SSDP PF04503.11 NM_023672.2_1 - 4.1e-97 325.8 75.8 4.1e-97 325.8 75.8 2.2 2 0 0 2 2 2 1 Single-stranded DNA binding protein, SSDP Mod_r PF07200.11 NM_033560.3_3 - 1.7e-35 122.1 17.3 3.8e-35 121.0 17.3 1.6 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein UEV PF05743.11 NM_033560.3_3 - 0.011 15.5 0.7 0.023 14.4 0.7 1.5 1 0 0 1 1 1 0 UEV domain Kunitz_BPTI PF00014.21 NM_007443.4_1 - 1.4e-33 114.7 23.9 8.9e-17 60.9 6.3 2.5 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Lipocalin PF00061.21 NM_007443.4_1 - 6.1e-30 104.2 0.1 8.7e-30 103.7 0.1 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Citrate_bind PF16114.3 NM_134037.3_2 - 5.6e-92 306.0 0.1 9.7e-92 305.2 0.1 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.19 NM_134037.3_2 - 1.8e-22 79.8 0.0 7.6e-20 71.1 0.0 2.9 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.17 NM_134037.3_2 - 1.1e-13 51.2 0.0 2e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.17 NM_134037.3_2 - 2.4e-12 47.3 0.0 4.8e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.8 NM_134037.3_2 - 1.4e-05 24.6 0.0 2.6e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.4 NM_134037.3_2 - 0.00096 18.8 0.0 0.0027 17.4 0.0 1.8 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain DEAD PF00270.27 NM_053183.2_1 - 1.8e-47 161.3 0.0 2.9e-47 160.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_053183.2_1 - 2.3e-31 108.3 0.2 3.1e-28 98.2 0.0 3.5 2 1 1 3 3 3 1 Helicase conserved C-terminal domain GUCT PF08152.10 NM_053183.2_1 - 5.2e-28 97.0 0.0 1.1e-27 96.0 0.0 1.6 1 0 0 1 1 1 1 GUCT (NUC152) domain ResIII PF04851.13 NM_053183.2_1 - 2.4e-10 40.5 0.0 5.6e-10 39.3 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.4 NM_053183.2_1 - 2.6e-06 26.8 0.0 2.6e-06 26.8 0.0 2.6 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.3 NM_053183.2_1 - 0.00056 19.0 0.0 0.0011 18.1 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.4 NM_053183.2_1 - 0.014 15.0 0.0 0.033 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.4 NM_053183.2_1 - 0.31 10.6 0.0 0.31 10.6 0.0 2.5 1 1 1 2 2 2 0 AAA domain Keratin_B2_2 PF13885.4 NM_001199309.1_1 - 0.0032 17.3 85.9 0.0032 17.3 85.9 6.3 1 1 2 3 3 3 2 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_001199309.1_1 - 0.0061 16.4 64.2 0.0061 16.4 64.2 4.3 1 1 3 4 4 4 1 Keratin, high sulfur B2 protein zf-H2C2_2 PF13465.4 NM_172918.4_3 - 3.5e-88 286.3 108.7 6.8e-09 35.6 0.9 16.2 17 0 0 17 17 16 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_172918.4_3 - 4.8e-54 177.8 123.8 2.1e-05 24.6 0.4 16.0 17 0 0 17 17 16 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_172918.4_3 - 3.1e-37 123.9 102.2 0.00065 20.2 1.3 15.6 15 0 0 15 15 15 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_172918.4_3 - 1.6e-28 98.0 89.2 0.00057 19.6 0.2 14.7 14 0 0 14 14 14 11 C2H2-type zinc finger KRAB PF01352.25 NM_172918.4_3 - 4.5e-23 80.5 0.1 9.4e-23 79.5 0.1 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_172918.4_3 - 3.1e-14 52.7 63.1 0.0028 17.8 0.2 12.9 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_172918.4_3 - 6.1e-07 29.3 63.3 0.0094 15.9 1.4 10.1 7 4 3 11 11 11 6 Zinc ribbon domain zf-C2HE PF16278.3 NM_172918.4_3 - 0.00047 20.4 70.1 0.97 9.8 7.9 11.5 3 2 5 8 8 8 4 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.3 NM_172918.4_3 - 0.014 16.0 55.1 0.36 11.5 0.7 7.7 3 2 2 7 7 7 0 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_172918.4_3 - 0.027 14.1 79.4 0.075 12.7 0.3 13.3 14 0 0 14 14 14 0 zinc-finger C2H2-type zf-met PF12874.5 NM_172918.4_3 - 0.062 13.6 0.4 0.062 13.6 0.4 11.4 13 0 0 13 13 12 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.5 NM_172918.4_3 - 0.14 12.3 62.1 1.3 9.2 2.0 9.4 1 1 4 8 8 8 0 C2H2 type zinc-finger (2 copies) DUF3268 PF11672.6 NM_172918.4_3 - 0.18 12.0 31.8 0.16 12.2 0.6 5.9 5 1 1 6 6 6 0 zinc-finger-containing domain XPA_N PF01286.16 NM_172918.4_3 - 2.3 8.2 58.4 12 5.9 0.5 13.5 14 0 0 14 14 14 0 XPA protein N-terminal Spin-Ssty PF02513.15 NM_001283030.1_3 - 2.1e-73 241.7 6.6 3.6e-26 90.5 0.1 3.5 3 0 0 3 3 3 3 Spin/Ssty Family E1_DerP2_DerF2 PF02221.13 NM_010745.2_2 - 0.00026 21.3 0.0 0.00037 20.8 0.0 1.2 1 0 0 1 1 1 1 ML domain PARP PF00644.18 NM_001163575.1_3 - 9e-36 123.3 0.0 2.1e-35 122.1 0.0 1.6 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain 7tm_4 PF13853.4 NM_001081301.2_1 - 1.9e-38 132.7 8.9 2.3e-38 132.4 8.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001081301.2_1 - 5.4e-18 65.1 5.6 9.5e-18 64.2 5.7 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Prokineticin PF06607.9 NM_015768.2_1 - 4.4e-44 148.6 4.9 6.8e-44 148.0 4.9 1.3 1 0 0 1 1 1 1 Prokineticin BTB PF00651.29 NM_028125.3_1 - 2.8e-24 85.3 1.1 4.1e-24 84.8 1.1 1.2 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.6 NM_028125.3_1 - 5e-06 26.5 0.2 8.6e-06 25.7 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BTB_3 PF16017.3 NM_028125.3_1 - 0.024 14.6 0.1 0.046 13.7 0.1 1.4 1 0 0 1 1 1 0 BTB/POZ domain Radial_spoke_3 PF06098.9 NM_025789.5_2 - 4.6e-127 423.0 6.6 5.9e-127 422.7 6.6 1.1 1 0 0 1 1 1 1 Radial spoke protein 3 AICARFT_IMPCHas PF01808.16 NM_025789.5_2 - 0.29 10.4 1.0 0.45 9.8 1.0 1.1 1 0 0 1 1 1 0 AICARFT/IMPCHase bienzyme CDC50 PF03381.13 NM_027651.1_2 - 7.7e-82 274.8 0.9 1.1e-81 274.3 0.1 1.5 1 1 1 2 2 2 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF4501 PF14946.4 NM_027651.1_2 - 0.04 13.9 0.1 0.086 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) DUF2614 PF11023.6 NM_027651.1_2 - 0.13 12.2 0.1 0.13 12.2 0.1 1.6 2 0 0 2 2 2 0 Zinc-ribbon containing domain Promethin PF16015.3 NM_027651.1_2 - 8.7 6.2 9.5 0.35 10.7 1.1 2.2 2 0 0 2 2 2 0 Promethin NGF PF00243.16 NM_001048139.1_2 - 3.6e-47 159.1 2.3 6e-47 158.4 2.3 1.4 1 0 0 1 1 1 1 Nerve growth factor family CYLD_phos_site PF16607.3 NM_001128170.2_1 - 4.8e-84 280.1 10.8 7.1e-84 279.5 10.8 1.3 1 0 0 1 1 1 1 Phosphorylation region of CYLD, unstructured CAP_GLY PF01302.23 NM_001128170.2_1 - 1.7e-33 114.3 4.5 1.6e-13 50.3 0.0 3.8 4 0 0 4 4 4 3 CAP-Gly domain UCH PF00443.27 NM_001128170.2_1 - 4.1e-09 36.2 0.1 7.3e-09 35.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-HIT PF04438.14 NM_001128170.2_1 - 1.1 9.0 5.4 4.3 7.2 5.4 2.1 1 0 0 1 1 1 0 HIT zinc finger Glyco_transf_29 PF00777.16 NM_009178.3_3 - 1.5e-60 204.7 0.0 2e-60 204.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Serpin PF00079.18 NM_009243.4_1 - 8.4e-118 393.7 3.2 1e-117 393.5 3.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) LON_substr_bdg PF02190.14 NM_009243.4_1 - 0.072 12.8 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 ATP-dependent protease La (LON) substrate-binding domain Cor1 PF04803.10 NM_001293678.1_3 - 3.5e-37 127.4 14.8 4.8e-37 127.0 14.8 1.2 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region YlbD_coat PF14071.4 NM_001293678.1_3 - 0.012 15.7 3.9 0.026 14.6 3.5 1.8 1 1 0 1 1 1 0 Putative coat protein KxDL PF10241.7 NM_001293678.1_3 - 0.49 10.6 7.1 0.43 10.7 5.2 1.7 1 1 1 2 2 2 0 Uncharacterized conserved protein HSCB_C PF07743.11 NM_001293678.1_3 - 0.65 10.4 4.2 1.5 9.3 3.9 1.8 1 1 0 1 1 1 0 HSCB C-terminal oligomerisation domain EF-hand_7 PF13499.4 NM_011154.2_3 - 2.1e-20 72.8 0.7 5.5e-19 68.3 0.4 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.4 NM_011154.2_3 - 0.00012 21.4 8.4 0.00039 19.7 0.1 3.5 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.4 NM_011154.2_3 - 0.011 15.5 1.1 0.44 10.5 0.1 3.6 3 0 0 3 3 3 0 EF-hand domain EF-hand_1 PF00036.30 NM_011154.2_3 - 0.011 15.1 0.9 0.76 9.3 0.2 3.9 5 0 0 5 5 5 0 EF hand EF-hand_8 PF13833.4 NM_011154.2_3 - 0.024 14.3 3.5 0.34 10.6 0.7 3.7 4 1 0 4 4 4 0 EF-hand domain pair RhoGEF PF00621.18 NM_133197.4_3 - 8.5e-40 136.8 1.4 8.5e-40 136.8 1.4 2.6 2 1 1 3 3 3 1 RhoGEF domain CRAL_TRIO_2 PF13716.4 NM_133197.4_3 - 1.3e-06 28.4 0.0 3.5e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PH PF00169.27 NM_133197.4_3 - 2.6e-06 27.7 0.6 6.1e-06 26.6 0.1 1.9 2 0 0 2 2 2 1 PH domain Not3 PF04065.13 NM_133197.4_3 - 0.058 12.7 0.1 0.058 12.7 0.1 3.2 3 0 0 3 3 3 0 Not1 N-terminal domain, CCR4-Not complex component MYCBPAP PF14646.4 NM_170671.2_1 - 1.3e-143 479.0 0.5 2.1e-143 478.3 0.5 1.4 1 0 0 1 1 1 1 MYCBP-associated protein family Sec7 PF01369.18 NM_001112699.1_1 - 1.4e-68 230.1 0.1 1.9e-68 229.7 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 NM_001112699.1_1 - 3.9e-29 101.1 0.1 6.7e-29 100.3 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_001112699.1_1 - 2e-05 24.8 0.0 3.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain CEP170_C PF15308.4 NM_001112699.1_1 - 0.0045 15.5 0.4 0.0063 15.0 0.4 1.1 1 0 0 1 1 1 1 CEP170 C-terminus WEMBL PF05701.9 NM_001112699.1_1 - 0.032 12.8 1.7 0.044 12.3 1.7 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light DUF342 PF03961.11 NM_001112699.1_1 - 0.034 12.6 1.3 0.048 12.1 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) PH_3 PF14593.4 NM_001112699.1_1 - 0.039 13.9 0.1 0.099 12.6 0.1 1.7 1 1 0 1 1 1 0 PH domain DUF812 PF05667.9 NM_001112699.1_1 - 0.16 10.7 3.7 0.24 10.1 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) BBS2_C PF14782.4 NM_001112699.1_1 - 0.19 10.3 1.9 1.8 7.1 1.4 2.0 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal APG6 PF04111.10 NM_001112699.1_1 - 0.19 10.9 3.9 0.22 10.8 2.3 1.7 2 0 0 2 2 2 0 Autophagy protein Apg6 GPS2_interact PF15784.3 NM_001112699.1_1 - 0.68 10.5 6.5 0.22 12.1 2.6 2.1 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain Rhodanese PF00581.18 NM_001162492.1_1 - 9e-29 100.0 0.0 1.8e-14 54.0 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain FAD_binding_7 PF03441.12 NM_009963.4_2 - 1.4e-67 226.8 0.1 2.1e-67 226.2 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.16 NM_009963.4_2 - 2.4e-47 160.9 0.0 4.5e-47 160.0 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase Peripla_BP_6 PF13458.4 NM_009963.4_2 - 0.016 14.8 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein zf-C3HC4 PF00097.23 NM_001177858.1_2 - 7e-07 28.9 7.0 7e-07 28.9 7.0 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001177858.1_2 - 2.9e-06 26.9 8.5 2.9e-06 26.9 8.5 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_001177858.1_2 - 2.9e-06 27.2 10.1 2.9e-06 27.2 10.1 2.3 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 NM_001177858.1_2 - 4.5e-06 26.4 3.3 4.5e-06 26.4 3.3 2.5 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_001177858.1_2 - 6.6e-05 22.5 8.6 6.6e-05 22.5 8.6 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001177858.1_2 - 7e-05 22.9 7.6 7e-05 22.9 7.6 2.8 3 0 0 3 3 2 1 Ring finger domain SPRY PF00622.26 NM_001177858.1_2 - 0.00022 21.2 0.1 0.00063 19.7 0.1 1.8 1 0 0 1 1 1 1 SPRY domain zf-RING_5 PF14634.4 NM_001177858.1_2 - 0.00031 20.5 6.7 0.00031 20.5 6.7 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-B_box PF00643.22 NM_001177858.1_2 - 0.0015 18.5 12.0 0.0015 18.5 12.0 3.6 2 1 1 3 3 3 1 B-box zinc finger zf-RING_6 PF14835.4 NM_001177858.1_2 - 0.0039 16.9 3.9 0.0039 16.9 3.9 1.8 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.4 NM_001177858.1_2 - 0.41 10.3 6.7 1.2 8.8 6.7 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Pou PF00157.15 NM_001252452.1_1 - 5.2e-38 128.8 1.0 1.2e-37 127.6 1.0 1.6 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 NM_001252452.1_1 - 1.4e-18 66.3 1.1 2.5e-18 65.5 1.1 1.4 1 0 0 1 1 1 1 Homeobox domain DUF521 PF04412.11 NM_001252452.1_1 - 0.091 11.3 0.1 0.13 10.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Homeobox_KN PF05920.9 NM_001252452.1_1 - 0.1 12.4 0.0 0.25 11.1 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain LIM PF00412.20 NM_001025565.2_2 - 5.8e-29 100.0 30.0 4.5e-16 58.7 3.6 3.5 3 0 0 3 3 3 2 LIM domain Homeobox PF00046.27 NM_001025565.2_2 - 9.1e-10 38.1 0.3 1.9e-09 37.1 0.3 1.5 1 0 0 1 1 1 1 Homeobox domain Forkhead PF00250.16 NM_008593.3_3 - 7.9e-37 125.3 0.0 1.3e-36 124.6 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain Tcf25 PF04910.12 NM_001037878.3_1 - 1.7e-116 388.9 1.2 2.1e-116 388.6 1.2 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 ABC_membrane PF00664.21 NM_008576.3_3 - 2.8e-92 309.1 27.3 3.3e-50 171.1 5.9 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 NM_008576.3_3 - 5.5e-53 179.0 0.0 1e-28 100.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 NM_008576.3_3 - 1.5e-08 34.3 1.6 0.0011 18.3 0.0 3.9 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.21 NM_008576.3_3 - 2.3e-05 24.3 0.5 0.18 11.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.4 NM_008576.3_3 - 0.00011 22.5 0.1 0.044 14.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.14 NM_008576.3_3 - 0.00015 21.6 0.3 0.051 13.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_25 PF13481.4 NM_008576.3_3 - 0.00037 20.0 0.9 0.0098 15.3 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.4 NM_008576.3_3 - 0.0017 17.9 1.5 0.37 10.4 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.4 NM_008576.3_3 - 0.0018 18.4 0.7 0.58 10.3 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_21 PF13304.4 NM_008576.3_3 - 0.0034 17.1 0.0 2.1 7.9 0.0 3.0 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.10 NM_008576.3_3 - 0.007 15.5 1.1 0.032 13.4 0.1 2.1 2 0 0 2 2 2 1 Zeta toxin ABC_ATPase PF09818.7 NM_008576.3_3 - 0.025 13.2 0.1 1 7.9 0.0 2.5 3 0 0 3 3 3 0 Predicted ATPase of the ABC class Roc PF08477.11 NM_008576.3_3 - 0.029 14.5 0.6 28 4.8 0.0 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.21 NM_008576.3_3 - 0.074 13.0 2.4 0.25 11.2 0.1 2.4 2 0 0 2 2 2 0 Dynamin family AAA_23 PF13476.4 NM_008576.3_3 - 0.088 13.2 0.2 21 5.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.15 NM_008576.3_3 - 0.12 12.3 2.3 5.7 6.8 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 Filament PF00038.19 NM_010277.3_3 - 4.3e-109 364.7 51.0 5.2e-109 364.5 51.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 NM_010277.3_3 - 1.4e-05 25.7 0.9 1.4e-05 25.7 0.9 2.0 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region DUF1664 PF07889.10 NM_010277.3_3 - 0.013 15.4 13.1 0.22 11.4 0.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.10 NM_010277.3_3 - 0.035 13.4 4.4 1.1 8.4 0.4 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Spc7 PF08317.9 NM_010277.3_3 - 0.41 9.4 45.2 0.38 9.4 10.9 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 NM_010277.3_3 - 2.4 8.2 47.8 0.28 11.3 15.5 3.3 2 1 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.4 NM_010277.3_3 - 6 6.0 33.9 0.58 9.3 12.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.8 NM_010277.3_3 - 8.5 6.4 19.7 2 8.5 5.1 3.0 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Cadherin PF00028.15 NM_023370.3_3 - 0 1443.1 35.4 8.5e-21 74.1 0.0 27.2 27 0 0 27 27 27 27 Cadherin domain Cadherin_2 PF08266.10 NM_023370.3_3 - 1.9e-30 104.3 0.0 0.0095 15.6 0.0 15.5 18 0 0 18 18 18 10 Cadherin-like Cadherin_3 PF16184.3 NM_023370.3_3 - 6e-18 64.7 40.2 0.011 15.6 0.0 19.0 22 0 0 22 22 22 7 Cadherin-like Cadherin_pro PF08758.9 NM_023370.3_3 - 3.4e-07 30.2 0.0 3.4 7.8 0.0 8.8 11 0 0 11 11 11 1 Cadherin prodomain like Metallothio PF00131.18 NM_013602.3_1 - 5.4e-18 64.7 65.5 9.3e-18 64.0 65.5 1.4 1 0 0 1 1 1 1 Metallothionein SMN PF06003.10 NM_009627.1_1 - 0.36 9.9 6.3 28 3.7 0.0 2.1 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) Calc_CGRP_IAPP PF00214.17 NM_009627.1_2 - 6.5e-28 97.4 0.0 1.2e-27 96.5 0.0 1.4 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family MFS_1 PF07690.14 NM_028140.4_3 - 1.9e-36 125.6 30.0 4.6e-29 101.3 15.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_028140.4_3 - 6.6e-11 41.6 8.0 6.6e-11 41.6 8.0 3.4 3 1 0 3 3 3 3 Sugar (and other) transporter SSF PF00474.15 NM_019810.4_2 - 1.6e-171 570.6 23.7 2.8e-171 569.7 23.7 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family TMEM239 PF15841.3 NM_019810.4_2 - 0.013 15.2 0.1 1 9.1 0.1 2.8 2 0 0 2 2 2 0 Transmembrane protein 239 family Augurin PF15187.4 NM_024283.3_2 - 3.3e-52 175.4 3.7 4.6e-52 174.9 3.7 1.2 1 0 0 1 1 1 1 Oesophageal cancer-related gene 4 RRM_1 PF00076.20 NM_011252.4_2 - 7.5e-23 80.0 0.1 1.2e-22 79.4 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 NM_011252.4_2 - 3.1e-22 78.2 12.2 3.1e-22 78.2 12.2 8.3 5 2 3 8 8 8 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 NM_011252.4_2 - 0.0067 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.4 NM_011252.4_2 - 0.044 13.2 0.0 0.097 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_011252.4_2 - 0.15 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Exo_endo_phos PF03372.21 NM_033134.3_3 - 6.3e-07 29.5 0.0 9.8e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Glyco_transf_18 PF15024.4 NM_172948.3_2 - 2.7e-265 881.2 0.0 3.2e-265 880.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 Hormone_recep PF00104.28 NM_008261.3_1 - 7.5e-40 136.6 0.1 1.1e-39 136.0 0.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_008261.3_1 - 1.9e-29 101.7 18.4 4e-29 100.7 18.4 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Ion_trans PF00520.29 NM_181317.4_2 - 7e-42 143.2 3.9 1.5e-41 142.1 3.9 1.6 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_181317.4_2 - 3.4e-29 100.9 0.2 1.1e-28 99.2 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_181317.4_2 - 4.2e-13 48.9 4.1 1.2e-12 47.4 4.1 1.9 1 0 0 1 1 1 1 Ion channel Ig_3 PF13927.4 NM_001190911.1_2 - 1.8e-44 150.1 2.3 3.3e-11 43.5 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.14 NM_001190911.1_2 - 8.6e-39 131.4 0.0 1.5e-11 44.1 0.0 5.7 5 1 0 5 5 5 4 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001190911.1_2 - 2.5e-35 120.5 0.4 5.1e-07 29.8 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 NM_001190911.1_2 - 5.6e-22 77.6 2.9 2.1e-05 24.5 0.0 5.2 4 1 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 NM_001190911.1_2 - 1.3e-10 41.2 0.1 0.12 12.5 0.0 6.4 5 2 1 6 6 6 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001190911.1_2 - 1.3e-10 41.0 0.2 1e-06 28.6 0.0 4.0 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 NM_001190911.1_2 - 4.8e-07 30.0 0.0 0.0042 17.4 0.0 4.1 4 0 0 4 4 4 1 Immunoglobulin C1-set domain Ig_5 PF16681.3 NM_001190911.1_2 - 0.00083 19.6 0.0 3 8.2 0.0 4.8 6 0 0 6 6 6 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 NM_001190911.1_2 - 0.0084 16.3 0.1 1.4 9.2 0.0 4.0 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 NM_001190911.1_2 - 0.045 13.7 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Mid2 PF04478.10 NM_001190911.1_2 - 0.048 13.4 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF572 PF04502.11 NM_026350.3_1 - 7.8e-98 327.9 7.8 9.5e-98 327.6 7.8 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Lon_C PF05362.11 NM_028782.2_1 - 3.1e-70 235.8 0.0 9.4e-70 234.2 0.0 1.9 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.14 NM_028782.2_1 - 1.8e-32 112.8 2.8 3.9e-32 111.7 2.8 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.27 NM_028782.2_1 - 2.1e-24 86.3 0.0 8.2e-24 84.4 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 NM_028782.2_1 - 3.8e-08 33.3 0.0 1.3e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.10 NM_028782.2_1 - 5.4e-07 29.0 0.0 1.8e-05 24.0 0.0 2.5 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.12 NM_028782.2_1 - 6.2e-07 29.6 0.0 1.9e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ChlI PF13541.4 NM_028782.2_1 - 8.3e-07 28.7 0.1 3.2e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.4 NM_028782.2_1 - 1.9e-06 28.3 1.8 1.5e-05 25.3 0.1 3.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_PrkA PF08298.9 NM_028782.2_1 - 2.4e-05 23.3 0.0 4.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_14 PF13173.4 NM_028782.2_1 - 7e-05 22.7 0.4 0.018 15.0 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_22 PF13401.4 NM_028782.2_1 - 0.0012 19.0 4.4 0.0038 17.4 0.0 3.5 4 1 0 4 4 3 1 AAA domain RNA_helicase PF00910.20 NM_028782.2_1 - 0.0063 16.8 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.4 NM_028782.2_1 - 0.0087 16.1 0.0 0.021 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.15 NM_028782.2_1 - 0.0089 15.7 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Viral_helicase1 PF01443.16 NM_028782.2_1 - 0.012 15.2 0.0 0.08 12.5 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.4 NM_028782.2_1 - 0.021 15.2 2.7 0.05 14.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_3 PF07726.9 NM_028782.2_1 - 0.021 14.5 0.0 0.24 11.1 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.15 NM_028782.2_1 - 0.021 14.7 0.0 0.055 13.3 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.10 NM_028782.2_1 - 0.024 14.4 0.1 0.11 12.3 0.0 2.1 3 0 0 3 3 2 0 NACHT domain DUF258 PF03193.14 NM_028782.2_1 - 0.033 14.0 0.0 0.13 12.0 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NB-ARC PF00931.20 NM_028782.2_1 - 0.036 12.9 1.3 0.069 12.0 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.4 NM_028782.2_1 - 0.07 12.7 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.4 NM_028782.2_1 - 0.084 13.2 0.0 0.084 13.2 0.0 2.7 2 1 0 2 2 1 0 AAA domain Torsin PF06309.9 NM_028782.2_1 - 0.1 12.6 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 Torsin SVIP PF15811.3 NM_001160345.1_3 - 1.1e-21 76.8 1.7 1.7e-21 76.3 1.7 1.2 1 0 0 1 1 1 1 Small VCP/p97-interacting protein Trypsin PF00089.24 NM_178855.4_1 - 9.5e-69 231.4 0.1 1.6e-68 230.7 0.1 1.4 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 NM_178855.4_1 - 5.5e-43 145.7 0.0 1.1e-26 93.2 0.0 2.8 3 0 0 3 3 3 2 CUB domain MAM PF00629.21 NM_178855.4_1 - 3.3e-38 130.9 1.1 6.7e-38 129.9 1.1 1.6 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu SEA PF01390.18 NM_178855.4_1 - 2.8e-20 72.4 1.0 5.7e-20 71.4 1.0 1.5 1 0 0 1 1 1 1 SEA domain Ldl_recept_a PF00057.16 NM_178855.4_1 - 2.5e-12 46.6 32.5 3e-09 36.8 10.8 2.9 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A SRCR PF00530.16 NM_178855.4_1 - 3.3e-09 37.0 2.3 4.2e-09 36.7 0.2 2.2 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 NM_178855.4_1 - 1.1e-06 28.9 0.4 3.3e-06 27.4 0.4 1.8 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF1986 PF09342.9 NM_178855.4_1 - 8.3e-06 26.0 0.2 2.1e-05 24.7 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) PRKCSH-like PF12999.5 NM_178855.4_1 - 0.33 10.6 8.6 2.1 8.0 2.3 2.4 2 0 0 2 2 2 0 Glucosidase II beta subunit-like Laminin_EGF PF00053.22 NM_001004157.2_2 - 3.7e-18 65.3 165.8 0.00022 21.1 6.8 10.6 4 2 6 10 10 10 8 Laminin EGF domain EGF_2 PF07974.11 NM_001004157.2_2 - 1.5e-05 25.1 183.7 0.002 18.3 6.9 13.7 10 5 2 12 12 12 7 EGF-like domain WD40 PF00400.30 NM_001039088.1_3 - 9.8e-12 45.1 30.6 0.0006 20.4 1.9 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001039088.1_3 - 2e-06 27.9 4.5 0.079 13.1 0.0 3.6 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 NM_001039088.1_3 - 3.3e-05 22.9 1.1 1 8.2 0.0 3.2 3 0 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Lectin_C PF00059.19 NM_020001.2_3 - 5.1e-21 75.3 3.3 5.1e-21 75.3 3.3 1.8 1 1 1 2 2 2 1 Lectin C-type domain Histone PF00125.22 NM_178196.4_1 - 1.9e-25 89.7 0.3 2.4e-25 89.3 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_178196.4_1 - 1.5e-06 28.3 0.6 2.7e-06 27.4 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 NM_178196.4_1 - 0.0048 17.2 0.0 0.0087 16.4 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.3 NM_178196.4_1 - 0.0063 16.4 0.2 0.0079 16.1 0.2 1.1 1 0 0 1 1 1 1 YscO-like protein Yae1_N PF09811.7 NM_178196.4_3 - 0.17 11.5 3.9 0.36 10.4 3.9 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Piwi PF02171.15 NM_021308.1_3 - 4.6e-86 288.6 0.1 6.3e-86 288.2 0.1 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.20 NM_021308.1_3 - 3e-32 111.2 0.4 5e-32 110.4 0.4 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.8 NM_021308.1_3 - 1e-08 34.5 0.0 2.5e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.3 NM_021308.1_3 - 0.0016 19.0 0.0 0.0029 18.2 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute tRNA-synt_2b PF00587.23 NM_033074.3_3 - 2.7e-37 128.3 0.0 4.6e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.18 NM_033074.3_3 - 3.7e-20 71.7 0.1 7.3e-20 70.8 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.19 NM_033074.3_3 - 1e-16 60.6 0.1 3.4e-16 58.9 0.0 1.9 2 0 0 2 2 2 1 TGS domain tRNA_SAD PF07973.12 NM_033074.3_3 - 4.4e-12 45.8 0.1 9.7e-12 44.7 0.1 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF2347 PF09804.7 NM_175528.4_3 - 7.5e-75 252.0 0.0 1.4e-74 251.1 0.0 1.4 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.8 NM_175528.4_3 - 1.8e-12 47.1 0.1 3.3e-12 46.2 0.1 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.7 NM_175528.4_3 - 1.8e-10 39.9 1.5 0.007 15.0 0.0 3.1 3 0 0 3 3 3 3 Transport protein Avl9 Baculo_LEF-11 PF06385.10 NM_175528.4_3 - 0.2 12.0 0.8 0.38 11.2 0.8 1.4 1 0 0 1 1 1 0 Baculovirus LEF-11 protein Aldolase_II PF00596.19 NM_001271858.1_1 - 2.6e-36 125.2 0.1 3.9e-36 124.6 0.1 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF3614 PF12267.6 NM_001271858.1_1 - 1 9.7 5.1 2.1 8.7 4.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3614) Peptidase_M19 PF01244.19 NM_007876.2_3 - 1.2e-118 395.8 0.0 1.4e-118 395.6 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) PI-PLC-X PF00388.17 NM_021280.3_3 - 1.8e-65 218.8 0.0 4.5e-65 217.5 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain SH2 PF00017.22 NM_021280.3_3 - 4.6e-47 157.8 0.1 3.8e-24 84.4 0.0 2.8 2 0 0 2 2 2 2 SH2 domain PI-PLC-Y PF00387.17 NM_021280.3_3 - 7.2e-39 132.6 0.0 1.7e-38 131.3 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.28 NM_021280.3_3 - 2.2e-15 56.6 0.0 7.4e-15 55.0 0.0 1.9 2 0 0 2 2 2 1 C2 domain SH3_1 PF00018.26 NM_021280.3_3 - 4.3e-15 54.9 1.3 9e-15 53.9 0.5 2.0 2 0 0 2 2 2 1 SH3 domain PH PF00169.27 NM_021280.3_3 - 3.7e-14 53.0 0.4 0.00048 20.5 0.1 4.0 3 0 0 3 3 3 3 PH domain SH3_9 PF14604.4 NM_021280.3_3 - 7.4e-09 35.2 1.5 8.1e-09 35.1 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 NM_021280.3_3 - 5.8e-08 32.2 0.0 1.4e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH_12 PF16457.3 NM_021280.3_3 - 8e-05 23.0 0.2 0.00031 21.1 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain GDPD PF03009.15 NM_021280.3_3 - 0.00079 19.1 0.0 0.0021 17.7 0.0 1.7 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PH_9 PF15410.4 NM_021280.3_3 - 0.14 12.4 0.1 2.7 8.2 0.0 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain 7tm_4 PF13853.4 NM_001005520.2_1 - 2.9e-62 210.8 21.6 3.5e-62 210.5 21.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001005520.2_1 - 1e-20 74.0 27.7 2.5e-20 72.7 27.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-HC5HC2H PF13771.4 NM_001167963.1_1 - 2.4e-18 66.0 3.9 2.4e-18 66.0 3.9 4.2 4 0 0 4 4 4 1 PHD-like zinc-binding domain HECT PF00632.23 NM_001167963.1_1 - 3.4e-10 39.8 0.2 8.5e-10 38.5 0.2 1.6 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) zf-HC5HC2H_2 PF13832.4 NM_001167963.1_1 - 7.4e-07 29.2 8.0 7.4e-07 29.2 8.0 3.2 3 1 1 4 4 4 1 PHD-zinc-finger like domain Synaptobrevin PF00957.19 NM_016796.3_1 - 3.9e-30 103.3 5.1 6e-30 102.8 5.1 1.3 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.11 NM_016796.3_1 - 0.065 13.3 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Fzo_mitofusin PF04799.11 NM_016796.3_1 - 0.16 11.3 1.6 0.25 10.7 1.6 1.2 1 0 0 1 1 1 0 fzo-like conserved region SSF PF00474.15 NM_001177621.1_2 - 5.3e-38 130.8 24.5 7.2e-38 130.4 24.5 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family FIST_C PF10442.7 NM_028049.2_1 - 1.2e-10 41.3 0.0 2.6e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 FIST C domain F-box PF00646.31 NM_028049.2_1 - 3.9e-05 23.3 0.7 7.3e-05 22.4 0.7 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 NM_028049.2_1 - 5.8e-05 22.8 0.4 0.00012 21.7 0.4 1.5 1 0 0 1 1 1 1 F-box-like FIST PF08495.8 NM_028049.2_1 - 0.00063 19.7 0.2 0.17 11.8 0.0 2.6 3 0 0 3 3 3 2 FIST N domain zf-C2H2_2 PF12756.5 NM_178845.3_2 - 9e-48 160.7 22.6 1e-22 80.2 4.4 3.6 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.4 NM_178845.3_2 - 8.3e-10 38.5 30.6 0.0022 18.6 0.6 6.5 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_178845.3_2 - 5.9e-05 23.1 2.8 5.9e-05 23.1 2.8 4.4 5 0 0 5 5 5 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.24 NM_178845.3_2 - 0.0011 19.2 2.1 0.0011 19.2 2.1 6.0 6 1 0 6 6 6 2 Zinc finger, C2H2 type zf-met PF12874.5 NM_178845.3_2 - 0.0049 17.1 18.6 0.039 14.2 2.1 3.9 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-BED PF02892.13 NM_178845.3_2 - 0.064 13.2 27.2 0.056 13.4 2.5 5.5 6 0 0 6 6 6 0 BED zinc finger zf-RVT PF13966.4 NM_178845.3_2 - 0.089 13.5 0.1 0.089 13.5 0.1 3.1 3 0 0 3 3 3 0 zinc-binding in reverse transcriptase BIR PF00653.19 NM_178845.3_2 - 0.56 10.8 12.1 1 10.0 0.7 4.7 5 0 0 5 5 5 0 Inhibitor of Apoptosis domain zf-C2H2_11 PF16622.3 NM_178845.3_2 - 1.8 8.3 11.6 4.5 7.0 3.2 3.7 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-DBF PF07535.10 NM_178845.3_2 - 4.2 7.4 9.3 16 5.6 1.4 3.0 2 0 0 2 2 2 0 DBF zinc finger SNF PF00209.16 NM_001040692.3_2 - 3.4e-179 596.8 24.6 4.4e-179 596.4 24.6 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family zf-CCHC_3 PF13917.4 NM_026075.3_2 - 7.7e-07 28.9 0.0 2e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.21 NM_026075.3_2 - 0.094 12.7 2.7 0.26 11.3 2.7 1.8 1 0 0 1 1 1 0 Zinc knuckle Spt5_N PF11942.6 NM_026075.3_2 - 2 9.3 23.1 1.8 9.4 21.9 1.4 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Chromo PF00385.22 NM_007625.2_2 - 1.7e-14 53.3 0.3 4.1e-14 52.1 0.3 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CBX7_C PF17218.1 NM_007625.2_2 - 1.8e-12 46.7 1.0 4e-12 45.5 1.0 1.6 1 0 0 1 1 1 1 CBX family C-terminal motif zf-H2C2_2 PF13465.4 NM_001083918.1_2 - 2.7e-91 296.1 123.1 8.9e-09 35.3 0.5 15.6 15 0 0 15 15 15 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001083918.1_2 - 3.3e-53 175.2 147.7 1.9e-05 24.7 5.6 15.6 15 0 0 15 15 15 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001083918.1_2 - 6.6e-22 76.2 123.1 0.0072 16.9 1.7 14.0 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 NM_001083918.1_2 - 6.2e-19 67.3 2.4 1.2e-18 66.3 2.4 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_11 PF16622.3 NM_001083918.1_2 - 7.9e-16 57.4 86.2 0.002 17.7 0.6 14.5 15 0 0 15 15 15 10 zinc-finger C2H2-type UXS1_N PF11803.6 NM_001083918.1_2 - 0.00056 20.1 0.0 19 5.5 0.0 4.8 3 2 0 3 3 3 1 UDP-glucuronate decarboxylase N-terminal zf-C2H2_6 PF13912.4 NM_001083918.1_2 - 0.62 10.0 101.3 0.34 10.8 0.4 13.1 12 0 0 12 12 12 0 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_001083918.1_2 - 2.6 7.7 117.2 0.094 12.4 0.9 14.7 12 2 0 12 12 12 0 C2H2-type zinc-finger domain Caldesmon PF02029.13 NM_145575.3_1 - 7.7e-180 598.7 80.9 9.2e-180 598.5 80.9 1.1 1 0 0 1 1 1 1 Caldesmon Frag1 PF10277.7 NM_001025582.2_2 - 1.6e-27 96.4 10.0 1.2e-26 93.5 1.9 2.6 2 1 1 3 3 3 2 Frag1/DRAM/Sfk1 family SLAIN PF15301.4 NM_001113423.2_3 - 4.6e-167 556.5 40.2 6.4e-167 556.1 40.2 1.2 1 0 0 1 1 1 1 SLAIN motif-containing family GIT_CC PF16559.3 NM_001113423.2_3 - 0.44 10.5 5.2 0.52 10.3 3.6 2.0 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor bZIP_1 PF00170.19 NM_001113423.2_3 - 1 9.4 5.0 0.19 11.7 1.1 1.8 2 0 0 2 2 2 0 bZIP transcription factor BIR PF00653.19 NM_001291503.1_3 - 4.8e-64 212.8 6.6 6.8e-21 74.6 0.7 3.8 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain CARD PF00619.19 NM_001291503.1_3 - 6.2e-22 77.3 0.8 1.4e-21 76.2 0.8 1.6 1 0 0 1 1 1 1 Caspase recruitment domain zf-C3HC4_3 PF13920.4 NM_001291503.1_3 - 2e-14 53.0 8.3 2e-14 53.0 8.3 4.0 6 0 0 6 6 6 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_001291503.1_3 - 2e-07 30.6 7.8 8.3e-07 28.6 7.8 2.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF2039 PF10217.7 NM_001291503.1_3 - 0.12 12.6 3.7 0.39 10.9 3.7 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) CENP-K PF11802.6 NM_181061.5_1 - 3.5e-82 275.8 15.8 5.3e-82 275.2 15.8 1.2 1 0 0 1 1 1 1 Centromere-associated protein K Baculo_PEP_C PF04513.10 NM_181061.5_1 - 0.25 11.3 6.8 0.11 12.4 2.3 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus KLRAQ PF10205.7 NM_181061.5_1 - 3.9 7.7 10.3 0.54 10.4 5.7 1.9 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Laminin_II PF06009.10 NM_181061.5_1 - 6.2 6.7 8.7 2 8.3 2.6 2.3 2 0 0 2 2 2 0 Laminin Domain II HIP1_clath_bdg PF16515.3 NM_181061.5_1 - 7 7.2 12.9 0.49 10.9 5.3 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Histone PF00125.22 NM_178195.2_1 - 6.7e-26 91.1 0.7 8.8e-26 90.7 0.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_178195.2_1 - 8.3e-07 29.1 1.0 1.1e-06 28.6 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 NM_178195.2_1 - 0.0014 19.0 0.0 0.0025 18.2 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.3 NM_178195.2_1 - 0.0027 17.6 0.3 0.0033 17.3 0.3 1.1 1 0 0 1 1 1 1 YscO-like protein Yae1_N PF09811.7 NM_178195.2_3 - 0.11 12.0 3.9 0.32 10.6 3.9 1.8 1 0 0 1 1 1 0 Essential protein Yae1, N terminal SCAPER_N PF16501.3 NM_001081341.1_1 - 2.5e-43 146.0 0.4 2.5e-43 146.0 0.4 2.5 2 0 0 2 2 2 1 S phase cyclin A-associated protein in the endoplasmic reticulum zf-met PF12874.5 NM_001081341.1_1 - 1e-05 25.6 0.6 3.2e-05 24.0 0.6 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type 7tm_4 PF13853.4 NM_146510.1_1 - 2.5e-52 178.2 13.4 3.2e-52 177.9 13.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146510.1_1 - 2.7e-20 72.6 16.6 7e-20 71.2 16.6 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146510.1_1 - 4.5e-05 22.8 12.1 0.00013 21.3 12.1 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Glutaredoxin PF00462.22 NM_028419.3_2 - 3.1e-18 65.6 0.0 6.1e-18 64.7 0.0 1.5 2 0 0 2 2 2 1 Glutaredoxin Sporozoite_P67 PF05642.9 NM_028419.3_2 - 0.77 7.6 1.8 0.89 7.4 1.8 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DIX PF00778.15 NM_178118.2_2 - 3.1e-30 103.7 0.0 5.6e-30 102.9 0.0 1.4 1 0 0 1 1 1 1 DIX domain CH PF00307.29 NM_178118.2_2 - 1.4e-15 57.3 0.0 2.4e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_178118.2_2 - 0.0078 15.9 0.6 0.023 14.4 0.0 2.1 3 0 0 3 3 3 1 CAMSAP CH domain Thiamine_BP PF01910.15 NM_178118.2_2 - 0.01 15.6 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 0 Thiamine-binding protein adh_short PF00106.23 NM_008290.2_3 - 5.6e-47 159.6 0.0 7.7e-47 159.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_008290.2_3 - 1.8e-28 99.6 0.0 2.4e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.8 NM_008290.2_3 - 6.3e-11 42.0 0.0 3.5e-10 39.6 0.0 1.8 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.8 NM_008290.2_3 - 1.2e-05 25.2 0.0 2.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 KR domain IBR PF01485.19 NM_146042.4_1 - 5.8e-16 58.3 26.5 1.3e-12 47.6 10.2 5.0 5 0 0 5 5 5 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.4 NM_146042.4_1 - 6.1 6.8 29.0 2.3 8.2 8.7 3.9 2 0 0 2 2 2 0 RING-type zinc-finger EGF PF00008.25 NM_010928.2_3 - 2.9e-216 698.7 561.0 1.8e-10 40.8 7.7 37.4 37 0 0 37 37 36 35 EGF-like domain hEGF PF12661.5 NM_010928.2_3 - 3.3e-133 430.3 478.1 2.2e-06 28.0 6.5 38.1 36 0 0 36 36 36 34 Human growth factor-like EGF EGF_CA PF07645.13 NM_010928.2_3 - 1.7e-62 207.3 545.2 2e-08 34.1 5.6 37.7 21 9 16 37 37 33 24 Calcium-binding EGF domain DUF3454 PF11936.6 NM_010928.2_3 - 2.2e-27 95.1 21.5 7.1e-27 93.5 21.5 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3454) Notch PF00066.15 NM_010928.2_3 - 9.8e-25 86.6 57.7 2.4e-11 43.7 16.6 15.8 18 0 0 18 18 5 3 LNR domain Ank_2 PF12796.5 NM_010928.2_3 - 1.6e-24 86.1 15.7 2.2e-12 47.3 1.9 3.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) NOD PF06816.11 NM_010928.2_3 - 4.4e-24 83.7 0.0 7.1e-24 83.1 0.0 1.3 1 0 0 1 1 1 1 NOTCH protein EGF_2 PF07974.11 NM_010928.2_3 - 8.8e-24 83.4 627.3 0.00086 19.5 1.4 37.8 36 2 2 38 38 35 26 EGF-like domain Ank PF00023.28 NM_010928.2_3 - 2e-22 78.4 11.7 2.7e-05 24.3 0.0 6.8 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.4 NM_010928.2_3 - 8.8e-21 73.5 14.5 1.5e-06 28.2 1.1 5.7 3 2 2 5 5 5 4 Ankyrin repeats (many copies) NODP PF07684.10 NM_010928.2_3 - 9.1e-17 60.8 0.1 9.1e-17 60.8 0.1 3.8 3 0 0 3 3 1 1 NOTCH protein Ank_3 PF13606.4 NM_010928.2_3 - 8e-14 50.3 5.1 0.069 13.6 0.0 6.7 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.4 NM_010928.2_3 - 1.6e-13 50.7 3.8 1.3e-05 25.5 0.0 5.0 2 1 2 5 5 5 4 Ankyrin repeats (many copies) EGF_3 PF12947.5 NM_010928.2_3 - 0.005 16.9 3.7 0.005 16.9 3.7 37.7 33 6 6 39 39 34 15 EGF domain Hydrolase PF00702.24 NM_133900.4_3 - 4.2e-15 56.5 0.0 5.7e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 NM_133900.4_3 - 2.4e-12 47.5 0.0 3.9e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.10 NM_133900.4_3 - 0.0001 21.8 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD_2 PF13419.4 NM_133900.4_3 - 0.00029 20.8 0.0 0.048 13.6 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.10 NM_133900.4_3 - 0.00093 18.5 0.0 0.0024 17.2 0.0 1.6 1 1 0 1 1 1 1 Putative Phosphatase StbA PF06406.9 NM_133900.4_3 - 0.066 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 StbA protein V-set PF07686.15 NM_144960.2_1 - 2e-12 47.1 0.0 4.2e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain LRR_8 PF13855.4 NM_001313761.1_1 - 5.4e-43 144.5 70.1 3.3e-09 36.2 6.1 9.4 5 3 3 9 9 9 9 Leucine rich repeat LRR_4 PF12799.5 NM_001313761.1_1 - 3.1e-20 71.7 66.4 0.00023 21.3 0.8 11.3 4 3 10 14 14 14 13 Leucine Rich repeats (2 copies) TIR PF01582.18 NM_001313761.1_1 - 2.6e-14 53.3 0.7 5.7e-14 52.2 0.7 1.6 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 NM_001313761.1_1 - 4.1e-06 26.9 0.1 7.7e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 NM_001313761.1_1 - 0.018 15.3 61.6 0.4 11.2 1.1 14.5 14 2 0 14 14 14 0 Leucine Rich Repeat LRR_9 PF14580.4 NM_001313761.1_1 - 0.021 14.2 18.8 1.2 8.5 1.5 5.1 2 2 3 5 5 5 0 Leucine-rich repeat PDE6_gamma PF04868.10 NM_012065.3_2 - 2.8e-46 155.6 0.2 3.8e-46 155.1 0.2 1.2 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit TNF PF00229.16 NM_033622.1_1 - 1.2e-10 41.3 0.0 2.1e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family 3Beta_HSD PF01073.17 NM_133943.2_2 - 1.4e-96 322.7 0.0 1.8e-96 322.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 NM_133943.2_2 - 3.6e-23 82.2 0.0 5.2e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 NM_133943.2_2 - 7.1e-15 54.7 0.1 4.8e-13 48.7 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 NM_133943.2_2 - 1.8e-14 53.7 0.0 3.4e-14 52.8 0.0 1.4 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 NM_133943.2_2 - 6e-11 42.5 0.0 8.7e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.13 NM_133943.2_2 - 6.8e-11 41.7 0.1 1.1e-10 41.0 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.8 NM_133943.2_2 - 1.3e-08 34.8 0.0 2.7e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.15 NM_133943.2_2 - 1.7e-07 30.5 0.0 2.9e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.11 NM_133943.2_2 - 6.2e-07 29.1 0.0 8.8e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.23 NM_133943.2_2 - 0.0001 21.7 0.1 0.00017 21.0 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.16 NM_133943.2_2 - 0.003 17.7 0.1 0.037 14.1 0.1 2.1 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Occludin_ELL PF07303.11 NM_029865.2_3 - 1e-24 87.0 0.0 1.4e-24 86.6 0.0 1.1 1 0 0 1 1 1 1 Occludin homology domain RabGAP-TBC PF00566.16 NM_013862.5_3 - 1e-57 195.1 3.8 1.9e-57 194.2 3.8 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3694 PF12473.6 NM_013862.5_3 - 4.9e-39 134.3 0.0 1.3e-38 132.9 0.0 1.8 1 0 0 1 1 1 1 Kinesin protein PID PF00640.21 NM_013862.5_3 - 0.0021 18.0 0.4 0.0021 18.0 0.4 2.0 2 1 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 NM_013862.5_3 - 0.0022 18.0 0.0 0.0046 17.0 0.0 1.6 1 0 0 1 1 1 1 Phosphotyrosine-binding domain CRR7 PF12095.6 NM_013862.5_3 - 0.096 13.0 0.8 13 6.1 0.2 2.7 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 PRIMA1 PF16101.3 NM_013862.5_3 - 0.99 9.3 3.0 1.3 9.0 1.7 1.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Ion_trans PF00520.29 NM_001083616.2_1 - 4.5e-258 851.2 86.4 2.5e-71 239.6 18.0 4.2 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 NM_001083616.2_1 - 9.2e-68 229.4 1.8 9.2e-68 229.4 1.8 2.3 2 1 0 2 2 2 1 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 NM_001083616.2_1 - 8.8e-36 121.4 0.0 2e-35 120.3 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 NM_001083616.2_1 - 1.5e-30 105.1 0.1 3.4e-30 104.0 0.1 1.6 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 NM_001083616.2_1 - 3.7e-08 32.3 78.9 1.5e-07 30.3 3.3 9.1 7 3 2 9 9 9 4 Polycystin cation channel Rer1 PF03248.11 NM_001083616.2_1 - 0.76 9.4 10.2 1.3 8.6 2.7 4.0 4 0 0 4 4 4 0 Rer1 family DUF1510 PF07423.9 NM_001083616.2_1 - 2.3 7.4 8.6 0.18 11.1 0.7 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1510) SNF2_N PF00176.21 NM_008234.3_2 - 4.7e-59 199.7 0.1 1.4e-58 198.2 0.1 1.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 NM_008234.3_2 - 2.2e-21 76.1 0.4 6.9e-21 74.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_008234.3_2 - 4.9e-08 33.0 0.3 9.6e-07 28.8 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 NM_008234.3_2 - 0.006 15.7 0.0 0.006 15.7 0.0 2.4 2 1 0 3 3 3 1 ERCC3/RAD25/XPB C-terminal helicase AAA_19 PF13245.4 NM_008234.3_2 - 0.13 12.5 0.0 0.37 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Shugoshin_C PF07557.9 NM_008234.3_2 - 0.14 11.9 2.2 0.31 10.7 2.2 1.6 1 0 0 1 1 1 0 Shugoshin C terminus Atg14 PF10186.7 NM_008234.3_2 - 4.5 6.1 15.7 9 5.1 15.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MCM_bind PF09739.7 NM_173409.4_2 - 0.072 11.4 1.0 0.093 11.0 1.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Sec1 PF00995.21 NM_001306178.1_1 - 7.5e-82 276.2 0.2 9.4e-82 275.9 0.2 1.1 1 0 0 1 1 1 1 Sec1 family cwf21 PF08312.10 NM_001306178.1_1 - 0.2 11.7 0.5 0.51 10.4 0.0 1.9 2 0 0 2 2 2 0 cwf21 domain PALP PF00291.23 NM_178224.3_2 - 2.4e-65 220.7 0.0 2.9e-65 220.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.26 NM_178224.3_2 - 3.5e-09 36.8 0.0 2.1e-07 31.1 0.0 3.0 2 0 0 2 2 2 1 CBS domain DUF4195 PF13836.4 NM_146224.5_1 - 2e-78 262.6 18.9 2e-78 262.6 18.9 3.2 3 1 0 3 3 3 1 Domain of unknown function (DUF4195) zf-Di19 PF05605.10 NM_146224.5_1 - 0.013 15.6 0.3 0.013 15.6 0.3 6.4 5 2 2 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 NM_146224.5_1 - 0.15 11.9 0.0 0.15 11.9 0.0 7.4 9 0 0 9 9 9 0 C2H2-type zinc finger zf-C2H2_9 PF16293.3 NM_146224.5_1 - 9.6 6.0 16.1 10 5.9 1.2 5.2 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) TSP_1 PF00090.17 NM_001301705.1_3 - 7.8e-29 99.5 94.6 3.9e-06 26.9 9.0 9.3 8 0 0 8 8 8 8 Thrombospondin type 1 domain ADAM_spacer1 PF05986.12 NM_001301705.1_3 - 9.4e-29 99.6 0.0 1.5e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 PLAC PF08686.9 NM_001301705.1_3 - 5.6e-10 39.6 10.5 5.8e-10 39.6 8.1 2.4 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain DEAD PF00270.27 NM_001159375.1_3 - 4.3e-44 150.2 0.3 6.5e-44 149.7 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001159375.1_3 - 2.2e-26 92.2 0.3 1.1e-25 90.0 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_001159375.1_3 - 9.3e-07 28.9 0.0 1.5e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 NM_001159375.1_3 - 0.0011 19.1 0.5 0.0025 18.0 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 NM_001159375.1_3 - 0.0049 16.5 0.0 0.0077 15.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.12 NM_001159375.1_3 - 0.085 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Helicase Flavi_DEAD PF07652.12 NM_001159375.1_3 - 0.11 12.3 0.0 0.58 10.0 0.0 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain FKBP_C PF00254.26 NM_008020.3_1 - 1.3e-34 118.2 0.0 2.1e-34 117.6 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Ank_4 PF13637.4 NM_001310533.1_1 - 0.12 12.8 0.1 0.27 11.8 0.1 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_001310533.1_1 - 0.15 12.5 0.1 0.36 11.3 0.1 1.6 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001310533.1_2 - 1.8e-21 76.1 3.1 4.8e-08 33.3 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_001310533.1_2 - 4.4e-18 65.5 0.1 1.8e-09 37.9 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 NM_001310533.1_2 - 6.5e-16 57.9 1.0 8.1e-07 29.1 0.1 3.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.4 NM_001310533.1_2 - 2.9e-14 51.6 2.1 1.9e-05 24.5 0.0 5.2 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.4 NM_001310533.1_2 - 2.9e-12 46.4 3.4 1.1e-06 28.6 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Rhomboid PF01694.20 NM_029777.3_3 - 7.7e-21 74.5 1.8 1.5e-20 73.6 1.8 1.3 1 0 0 1 1 1 1 Rhomboid family DUF523 PF04463.10 NM_029777.3_3 - 0.097 12.6 0.2 0.18 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF523) UIM PF02809.18 NM_029777.3_3 - 0.41 10.6 1.7 0.79 9.6 1.7 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif BRO1 PF03097.16 NM_001164677.1_3 - 7.2e-113 377.2 4.8 1.4e-112 376.2 4.8 1.5 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.4 NM_001164677.1_3 - 1.7e-92 309.7 11.5 1.7e-92 309.7 11.5 2.0 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV PH PF00169.27 NM_001163185.1_2 - 6.9e-08 32.8 0.0 1.1e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_001163185.1_2 - 3.5e-05 24.0 0.2 8.1e-05 22.9 0.2 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain 7tm_4 PF13853.4 NM_146550.1_1 - 1.9e-49 168.8 21.8 2.5e-49 168.4 21.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146550.1_1 - 7e-24 84.3 22.8 1.4e-23 83.3 22.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-RNPHF PF08080.10 NM_146550.1_1 - 0.071 12.9 0.4 1.9 8.4 0.0 2.5 2 0 0 2 2 2 0 RNPHF zinc finger Pkinase_Tyr PF07714.15 NM_001190974.1_1 - 3.5e-89 298.4 0.0 4.5e-89 298.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001190974.1_1 - 1.5e-36 126.0 0.0 2e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 NM_001190974.1_1 - 1.7e-19 69.8 0.3 3e-10 40.2 0.0 2.5 2 0 0 2 2 2 2 Fibronectin type III domain Ig_3 PF13927.4 NM_001190974.1_1 - 3.1e-16 59.6 1.1 1.4e-07 31.9 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 NM_001190974.1_1 - 7.2e-13 48.6 0.0 3.9e-06 27.0 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001190974.1_1 - 1.4e-10 41.1 2.3 2.3e-06 27.5 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 NM_001190974.1_1 - 5.4e-09 35.9 0.0 2.5e-05 24.1 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.15 NM_001190974.1_1 - 0.00017 21.5 0.0 0.00046 20.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain C1-set PF07654.13 NM_001190974.1_1 - 0.0056 17.0 0.0 0.062 13.7 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin C1-set domain DUF4381 PF14316.4 NM_001190974.1_1 - 0.025 14.7 0.1 0.053 13.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF3915 PF13054.4 NM_001190974.1_1 - 2.4 8.0 9.4 4.6 7.1 9.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Peptidase_M28 PF04389.15 NM_001289511.1_1 - 1.8e-13 50.5 0.0 2.8e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.20 NM_001289511.1_1 - 1.1e-09 38.1 0.0 2.2e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 PA domain TFR_dimer PF04253.13 NM_001289511.1_1 - 5.8e-06 26.3 0.0 1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Collectrin PF16959.3 NM_020626.2_3 - 2.8e-66 221.9 1.0 9.3e-66 220.2 0.2 2.0 2 0 0 2 2 2 1 Renal amino acid transporter PufQ PF05398.9 NM_020626.2_3 - 0.099 12.7 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 PufQ cytochrome subunit Phage_holin_2_3 PF16080.3 NM_020626.2_3 - 1.1 9.0 3.8 2.2 8.0 3.8 1.4 1 0 0 1 1 1 0 Bacteriophage holin family HP1 HPIP PF15226.4 NM_181821.1_1 - 1.4e-54 183.9 9.4 2.3e-53 180.1 9.4 2.3 1 1 0 1 1 1 1 HCF-1 beta-propeller-interacting protein family RRM_5 PF13893.4 NM_177301.5_1 - 5.2e-60 200.4 0.0 8.5e-50 167.4 0.0 3.2 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 NM_177301.5_1 - 4.2e-22 77.6 0.4 3.2e-08 33.1 0.0 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_177301.5_1 - 6.2e-07 29.0 0.0 0.22 11.3 0.0 3.3 3 0 0 3 3 3 3 Occluded RNA-recognition motif DUF4523 PF15023.4 NM_177301.5_1 - 0.00013 21.8 0.1 0.00048 19.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4523) Limkain-b1 PF11608.6 NM_177301.5_1 - 0.00023 21.0 0.0 0.54 10.2 0.0 2.7 2 0 0 2 2 2 2 Limkain b1 Dscam_C PF12355.6 NM_177301.5_1 - 0.00033 21.5 0.4 0.00088 20.1 0.4 1.7 1 0 0 1 1 1 1 Down syndrome cell adhesion molecule C terminal RRM_3 PF08777.9 NM_177301.5_1 - 0.074 13.0 0.0 0.82 9.6 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif MA3 PF02847.15 NM_001033457.2_3 - 1.4e-23 82.9 0.7 2.8e-23 81.9 0.7 1.6 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.17 NM_001033457.2_3 - 2e-17 63.4 0.5 2e-17 63.4 0.5 2.2 2 0 0 2 2 2 1 MIF4G domain DDE_Tnp_1_7 PF13843.4 NM_001162919.1_2 - 6.2e-47 160.5 1.7 2.4e-41 142.1 0.3 2.1 2 0 0 2 2 2 2 Transposase IS4 DDE_Tnp_1_7 PF13843.4 NM_001162919.1_3 - 6.8e-12 45.2 0.0 1e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 ABC1 PF03109.14 NM_023341.3_2 - 5.1e-32 110.4 0.0 8.6e-32 109.7 0.0 1.4 1 0 0 1 1 1 1 ABC1 family TMC PF07810.11 NM_177695.4_3 - 2.6e-40 137.3 1.7 2.6e-40 137.3 1.7 2.8 3 0 0 3 3 3 1 TMC domain DUF3671 PF12420.6 NM_177695.4_3 - 0.82 9.6 6.2 0.42 10.6 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function SH2 PF00017.22 NM_009168.2_2 - 1.4e-14 53.8 0.0 2.1e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 SH2 domain GKAP PF03359.11 NM_001128180.1_1 - 2e-153 510.9 4.2 2e-153 510.9 4.2 2.5 2 1 0 2 2 2 1 Guanylate-kinase-associated protein (GKAP) protein zf-DHHC PF01529.18 NM_027476.3_1 - 7.7e-25 87.4 5.8 1.8e-24 86.3 5.8 1.6 1 0 0 1 1 1 1 DHHC palmitoyltransferase Gasdermin PF04598.10 NM_028992.1_1 - 3.1e-159 530.8 0.2 3.6e-159 530.5 0.2 1.0 1 0 0 1 1 1 1 Gasdermin family Orthopox_A47 PF06334.9 NM_028992.1_1 - 0.023 13.8 0.3 0.037 13.2 0.3 1.3 1 0 0 1 1 1 0 Orthopoxvirus A47 protein Trypsin PF00089.24 NM_015775.2_3 - 2.8e-67 226.6 0.1 4.1e-67 226.1 0.1 1.3 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.4 NM_015775.2_3 - 9e-31 106.2 1.5 1.7e-30 105.3 1.5 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF1986 PF09342.9 NM_015775.2_3 - 8.5e-10 38.9 0.1 1.6e-09 38.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SRCR PF00530.16 NM_015775.2_3 - 1e-06 29.1 0.1 2.6e-06 27.7 0.1 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Ldl_recept_a PF00057.16 NM_015775.2_3 - 1.3e-06 28.4 9.9 3e-06 27.2 9.9 1.7 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Trypsin_2 PF13365.4 NM_015775.2_3 - 0.00016 22.5 0.0 0.00035 21.4 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Syntaxin PF00804.23 NM_001025307.1_2 - 4.5e-60 202.6 13.7 8.6e-60 201.7 13.7 1.5 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.17 NM_001025307.1_2 - 1.2e-16 60.3 3.4 1.2e-16 60.3 3.4 3.1 3 0 0 3 3 3 1 SNARE domain Syntaxin_2 PF14523.4 NM_001025307.1_2 - 1.2e-08 35.1 3.8 1.2e-08 35.1 3.8 2.0 2 0 0 2 2 2 1 Syntaxin-like protein Branch PF02485.19 NM_001025307.1_2 - 0.011 15.1 0.2 0.02 14.3 0.2 1.3 1 0 0 1 1 1 0 Core-2/I-Branching enzyme SIMPL PF04402.12 NM_001025307.1_2 - 0.06 13.7 1.1 0.11 12.8 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF541) Ion_trans PF00520.29 NM_020277.2_1 - 3.3e-11 42.7 18.3 7.9e-11 41.5 18.3 1.6 1 1 0 1 1 1 1 Ion transport protein Sina PF03145.14 NM_001308385.1_3 - 3.5e-89 297.9 0.2 4.6e-89 297.6 0.2 1.1 1 0 0 1 1 1 1 Seven in absentia protein family TRAF_BIRC3_bd PF16673.3 NM_001326601.1_3 - 5.1e-15 54.9 3.6 8.5e-15 54.2 3.6 1.3 1 0 0 1 1 1 1 TNF receptor-associated factor BIRC3 binding domain Sld5 PF05916.9 NM_030198.3_1 - 1.6e-07 31.6 0.0 3.3e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 GINS complex protein Ribosomal_L21e PF01157.16 NM_030198.3_2 - 7.2e-18 64.2 4.1 1.3e-17 63.4 4.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e Ribosomal_L21e PF01157.16 NM_030198.3_3 - 1.8e-12 46.8 0.1 3.8e-12 45.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L21e LRR_4 PF12799.5 NM_001085412.2_2 - 0.00052 20.2 14.6 4.4 7.7 1.3 6.4 5 1 0 6 6 6 3 Leucine Rich repeats (2 copies) Sushi PF00084.18 NM_133836.2_1 - 0.00032 21.1 0.4 0.00076 19.9 0.4 1.7 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) DUF3180 PF11377.6 NM_133836.2_1 - 0.033 14.2 0.2 0.056 13.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3180) DUF1640 PF07798.9 NM_025515.3_1 - 1.7e-58 197.4 14.6 2.2e-58 197.0 14.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) JAKMIP_CC3 PF16034.3 NM_025515.3_1 - 0.00056 19.8 9.2 0.00079 19.3 9.2 1.2 1 0 0 1 1 1 1 JAKMIP CC3 domain Ion_trans PF00520.29 NM_001081023.1_1 - 1.4e-257 849.6 83.8 1.4e-72 243.7 16.7 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 NM_001081023.1_1 - 2.3e-35 120.1 0.0 5.7e-35 118.8 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 NM_001081023.1_1 - 6e-29 100.0 0.1 1.4e-28 98.8 0.1 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 NM_001081023.1_1 - 1.2e-12 47.2 21.8 1.2e-10 40.6 6.6 9.5 6 4 3 9 9 9 3 Polycystin cation channel CAC1F_C PF16885.3 NM_001081023.1_1 - 1.1e-07 31.7 0.1 1.3e-05 24.9 0.0 2.5 2 0 0 2 2 2 2 Voltage-gated calcium channel subunit alpha, C-term DUF2670 PF10875.6 NM_001081023.1_1 - 0.7 9.9 3.1 2.9 7.8 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2670) Pkinase PF00069.23 NM_001171005.1_1 - 4.5e-70 235.9 0.0 6.7e-70 235.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001171005.1_1 - 2e-32 112.4 0.0 2.7e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 NM_001171005.1_1 - 1.7e-24 85.3 19.1 5.7e-14 51.6 3.0 3.5 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 NM_001171005.1_1 - 5.4e-10 39.6 4.1 1.8e-08 34.7 0.1 3.8 3 1 1 4 4 4 1 PH domain Kinase-like PF14531.4 NM_001171005.1_1 - 1.9e-06 27.2 0.0 8.8e-06 25.1 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.12 NM_001171005.1_1 - 4.8e-05 22.7 0.0 8.4e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family C1_2 PF03107.14 NM_001171005.1_1 - 0.00021 21.4 18.6 0.017 15.3 1.6 3.5 3 0 0 3 3 3 2 C1 domain PHD PF00628.27 NM_001171005.1_1 - 0.68 9.7 18.9 3.3 7.5 3.2 3.4 2 0 0 2 2 2 0 PHD-finger p450 PF00067.20 NM_177307.3_2 - 7.5e-122 407.3 0.0 9.1e-122 407.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Mito_fiss_reg PF05308.9 NM_001253391.1_3 - 1.8e-79 267.2 1.7 2.4e-79 266.7 1.7 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator zf-RING_2 PF13639.4 NM_001025309.1_2 - 4.7e-10 39.4 15.1 1.8e-09 37.6 15.1 2.1 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.5 NM_001025309.1_2 - 3.2e-05 24.0 11.9 8.9e-05 22.6 11.9 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 NM_001025309.1_2 - 4e-05 23.3 10.9 4e-05 23.3 10.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001025309.1_2 - 0.00017 21.2 14.6 0.00047 19.8 14.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001025309.1_2 - 0.00068 19.4 12.3 0.0023 17.7 12.3 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_001025309.1_2 - 0.00099 18.9 10.0 0.00099 18.9 10.0 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 NM_001025309.1_2 - 0.0065 16.2 11.8 0.0065 16.2 11.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 NM_001025309.1_2 - 0.0083 16.0 8.3 0.019 14.9 8.3 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 NM_001025309.1_2 - 0.011 15.3 9.9 0.034 13.7 9.9 1.9 1 0 0 1 1 1 0 RING-like zinc finger Rad50_zn_hook PF04423.12 NM_001025309.1_2 - 7.2 6.4 7.5 1.7 8.4 0.1 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-H2C2_2 PF13465.4 NM_001204908.1_3 - 5.8e-67 219.2 59.0 1.4e-08 34.7 1.0 11.3 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001204908.1_3 - 3.8e-52 171.8 66.6 1.3e-06 28.4 2.1 10.5 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001204908.1_3 - 6.2e-32 107.4 64.5 0.00093 19.7 1.2 10.6 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001204908.1_3 - 1.1e-13 50.5 48.5 0.057 13.0 0.2 9.7 9 0 0 9 9 9 7 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 NM_001204908.1_3 - 3.7e-10 39.7 17.2 0.11 12.8 0.1 9.3 10 0 0 10 10 9 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001204908.1_3 - 7.2e-08 32.3 42.4 0.064 13.3 1.0 7.6 4 3 5 9 9 9 7 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_001204908.1_3 - 0.0009 19.8 24.8 0.95 10.1 0.3 5.8 1 1 5 6 6 6 3 zinc-ribbon family zf-C2H2_6 PF13912.4 NM_001204908.1_3 - 0.013 15.3 47.9 1.3 8.9 0.1 10.2 10 0 0 10 10 10 0 C2H2-type zinc finger HypA PF01155.17 NM_001204908.1_3 - 0.052 13.4 26.7 3.4 7.6 1.8 5.6 1 1 4 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA SprT-like PF10263.7 NM_001204908.1_3 - 0.066 12.9 39.8 1.5 8.5 6.5 5.8 1 1 3 4 4 3 0 SprT-like family ADK_lid PF05191.12 NM_001204908.1_3 - 0.1 12.5 18.7 36 4.4 0.0 6.8 4 3 4 8 8 8 0 Adenylate kinase, active site lid zf-met PF12874.5 NM_001204908.1_3 - 0.12 12.6 42.3 0.28 11.5 0.7 9.0 9 0 0 9 9 9 0 Zinc-finger of C2H2 type zf-LYAR PF08790.9 NM_001204908.1_3 - 0.2 11.5 27.5 1.9 8.3 0.1 8.6 9 0 0 9 9 9 0 LYAR-type C2HC zinc finger FYDLN_acid PF09538.8 NM_001204908.1_3 - 0.4 11.2 22.3 68 4.1 0.7 8.1 2 2 6 8 8 8 0 Protein of unknown function (FYDLN_acid) zf-trcl PF13451.4 NM_001204908.1_3 - 0.48 10.2 39.7 13 5.6 0.1 9.5 8 2 1 9 9 9 0 Probable zinc-ribbon domain zf-C2HC_2 PF13913.4 NM_001204908.1_3 - 0.61 9.9 46.3 0.21 11.4 0.2 9.3 10 0 0 10 10 10 0 zinc-finger of a C2HC-type BolA PF01722.16 NM_001204908.1_3 - 1 9.6 11.6 34 4.7 0.1 4.6 3 1 1 4 4 4 0 BolA-like protein zf-Di19 PF05605.10 NM_001204908.1_3 - 1.9 8.7 40.4 0.049 13.8 1.7 6.3 3 1 5 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding DUF3268 PF11672.6 NM_001204908.1_3 - 2.1 8.5 22.5 0.23 11.6 0.5 5.0 1 1 6 8 8 8 0 zinc-finger-containing domain zf-H2C2_5 PF13909.4 NM_001204908.1_3 - 2.7 7.7 53.9 0.054 13.1 3.4 9.5 10 0 0 10 10 9 0 C2H2-type zinc-finger domain Peptidase_M14 PF00246.22 NM_018867.5_3 - 2.7e-74 250.4 0.1 3.9e-74 249.9 0.1 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase F5_F8_type_C PF00754.23 NM_018867.5_3 - 3.2e-30 104.7 0.1 6e-30 103.8 0.1 1.5 1 0 0 1 1 1 1 F5/8 type C domain CarboxypepD_reg PF13620.4 NM_018867.5_3 - 1.3e-12 47.7 0.0 2.6e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 NM_018867.5_3 - 0.02 14.7 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 CarboxypepD_reg-like domain TUDOR PF00567.22 NM_001277730.1_1 - 9.3e-21 74.0 0.1 2.2e-20 72.8 0.1 1.6 1 0 0 1 1 1 1 Tudor domain OST-HTH PF12872.5 NM_001277730.1_1 - 4.9e-20 71.1 0.4 3.9e-09 36.1 0.0 2.6 2 0 0 2 2 2 2 OST-HTH/LOTUS domain MAP65_ASE1 PF03999.10 NM_028386.1_1 - 5.4 5.5 5.1 7.3 5.0 5.1 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Asp_Arg_Hydrox PF05118.13 NM_028386.1_3 - 5.2e-49 165.9 0.0 7.1e-49 165.5 0.0 1.2 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Cystatin PF00031.19 NM_001102410.1_1 - 3.4e-68 225.8 0.5 1.8e-27 95.3 0.0 3.2 3 0 0 3 3 3 3 Cystatin domain Cathelicidins PF00666.15 NM_001102410.1_1 - 7.8e-16 58.1 5.3 2.4e-05 24.5 0.6 3.4 3 0 0 3 3 3 3 Cathelicidin SQAPI PF16845.3 NM_001102410.1_1 - 0.00016 21.9 0.0 0.21 11.8 0.0 2.6 2 0 0 2 2 2 2 Aspartic acid proteinase inhibitor Spp-24 PF07448.9 NM_001102410.1_1 - 0.00019 21.4 2.0 0.97 9.5 0.0 3.5 3 0 0 3 3 3 2 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Bradykinin PF06753.10 NM_001102410.1_1 - 0.027 14.0 4.3 0.053 13.1 4.3 1.5 1 0 0 1 1 1 0 Bradykinin DnaJ_CXXCXGXG PF00684.17 NM_001102410.1_1 - 3.7 7.9 7.0 2.2 8.6 2.7 2.5 2 0 0 2 2 2 0 DnaJ central domain Ig_2 PF13895.4 NM_011090.2_3 - 1.7e-33 114.7 20.5 3.2e-07 30.5 0.2 6.2 6 0 0 6 6 6 6 Immunoglobulin domain Ig_3 PF13927.4 NM_011090.2_3 - 8.4e-31 106.3 9.9 6.2e-06 26.6 0.1 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 NM_011090.2_3 - 1.4e-24 85.9 16.8 9.6e-07 28.8 0.2 6.3 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 NM_011090.2_3 - 8.4e-09 35.3 0.8 0.097 12.6 0.0 5.7 6 0 0 6 6 6 2 Immunoglobulin I-set domain V-set PF07686.15 NM_011090.2_3 - 1.4e-06 28.3 15.4 0.36 10.9 0.1 6.4 5 2 1 6 6 6 4 Immunoglobulin V-set domain Izumo-Ig PF16706.3 NM_011090.2_3 - 4.4e-05 23.3 1.3 0.22 11.5 0.1 4.2 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Zona_pellucida PF00100.21 NM_010959.2_1 - 3.1e-44 151.5 0.0 5.6e-44 150.7 0.0 1.4 1 0 0 1 1 1 1 Zona pellucida-like domain FXa_inhibition PF14670.4 NM_010959.2_1 - 7.1e-17 61.3 60.4 8.6e-10 38.6 13.3 4.6 5 0 0 5 5 5 3 Coagulation Factor Xa inhibitory site cEGF PF12662.5 NM_010959.2_1 - 2.8e-05 23.8 24.0 0.0028 17.4 0.7 4.4 4 0 0 4 4 4 3 Complement Clr-like EGF-like Glyco_transf_54 PF04666.11 NM_001205098.1_1 - 4.8e-93 311.0 2.5 7.9e-93 310.3 2.5 1.3 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF3915 PF13054.4 NM_001170333.1_1 - 0.0049 16.7 9.7 0.0077 16.1 9.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 NM_001170333.1_1 - 1.2 7.2 18.5 1.6 6.8 18.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family Lectin_C PF00059.19 NM_001170333.1_3 - 2e-19 70.2 5.3 2e-19 70.2 5.3 2.1 2 0 0 2 2 2 1 Lectin C-type domain DUF3915 PF13054.4 NM_001170333.1_3 - 9.1e-07 28.8 1.6 1.7e-06 27.9 1.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) WBP-1 PF11669.6 NM_001170333.1_3 - 0.016 15.7 2.4 0.082 13.4 1.0 2.4 2 0 0 2 2 2 0 WW domain-binding protein 1 EphA2_TM PF14575.4 NM_001170333.1_3 - 0.14 12.8 0.3 2.9 8.6 0.1 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Atrophin-1 PF03154.13 NM_001170333.1_3 - 0.21 9.7 18.1 0.31 9.2 18.1 1.1 1 0 0 1 1 1 0 Atrophin-1 family Apis_Csd PF11671.6 NM_001170333.1_3 - 0.24 11.3 2.8 0.44 10.4 2.8 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein Conotoxin PF02950.15 NM_001170333.1_3 - 0.26 12.2 3.0 0.46 11.4 0.3 2.4 2 0 0 2 2 2 0 Conotoxin Tektin PF03148.12 NM_027660.1_2 - 7.3e-146 485.7 34.1 8.4e-146 485.5 34.1 1.0 1 0 0 1 1 1 1 Tektin family Cellulose_synt PF03552.12 NM_027660.1_2 - 0.053 11.9 0.0 0.073 11.4 0.0 1.2 1 0 0 1 1 1 0 Cellulose synthase LOH1CR12 PF10158.7 NM_027660.1_2 - 0.12 12.3 10.3 0.74 9.7 1.6 3.4 2 1 1 3 3 3 0 Tumour suppressor protein DASH_Dad4 PF08650.8 NM_027660.1_2 - 0.48 10.3 4.1 5.1 7.0 1.3 2.9 2 1 0 2 2 2 0 DASH complex subunit Dad4 Baculo_PEP_C PF04513.10 NM_027660.1_2 - 0.71 9.8 10.5 1.2 9.1 5.5 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus JIP_LZII PF16471.3 NM_027660.1_2 - 0.85 9.7 11.5 11 6.2 2.1 4.1 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II Sin3_corepress PF08295.10 NM_027660.1_2 - 4.3 7.3 8.1 1.7 8.6 0.5 3.4 3 1 0 3 3 3 0 Sin3 family co-repressor 7tm_4 PF13853.4 NM_146636.1_1 - 1.3e-54 185.7 22.8 1.7e-54 185.4 22.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146636.1_1 - 1.6e-18 66.8 23.0 2.8e-18 66.0 23.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146636.1_1 - 4.6e-06 26.1 24.1 7e-06 25.5 24.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx GST_C_2 PF13410.4 NM_146636.1_1 - 0.19 11.5 0.2 0.53 10.1 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF1772 PF08592.9 NM_146636.1_1 - 8.5 6.6 13.1 0.27 11.4 3.7 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) zf-CCHC PF00098.21 NM_029158.2_1 - 7.1e-47 155.4 73.1 7.1e-08 32.1 2.8 8.1 8 0 0 8 8 8 7 Zinc knuckle zf-CCHC_4 PF14392.4 NM_029158.2_1 - 1.3e-11 43.9 46.8 0.0018 17.8 0.3 7.3 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.4 NM_029158.2_1 - 1.9e-07 30.6 50.5 0.063 12.9 1.9 7.3 5 1 2 7 7 7 5 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.4 NM_029158.2_1 - 5.7e-07 29.3 58.5 0.0032 17.3 1.6 8.2 4 1 4 8 8 8 5 Zinc knuckle zf-CCHC_2 PF13696.4 NM_029158.2_1 - 0.045 13.4 1.5 0.045 13.4 1.5 7.5 8 0 0 8 8 8 0 Zinc knuckle Abhydrolase_1 PF00561.18 NM_022419.3_3 - 5.3e-23 81.8 0.1 1.6e-17 63.9 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 NM_022419.3_3 - 6e-16 58.3 1.5 9.3e-15 54.4 1.5 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.5 NM_022419.3_3 - 1.4e-15 58.4 0.1 3.5e-15 57.1 0.1 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 NM_022419.3_3 - 0.0033 17.1 0.3 1.6 8.4 0.0 2.8 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase DUF2920 PF11144.6 NM_022419.3_3 - 0.0092 15.0 0.0 2.9 6.8 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF2920) FSH1 PF03959.11 NM_022419.3_3 - 0.031 13.8 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Peptidase_S9 PF00326.19 NM_022419.3_3 - 0.036 13.4 0.0 0.18 11.1 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family Peptidase_S15 PF02129.16 NM_022419.3_3 - 0.049 13.1 0.0 3 7.2 0.0 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_4 PF08386.8 NM_022419.3_3 - 0.051 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_8 PF06259.10 NM_022419.3_3 - 0.086 12.3 0.1 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Ser_hydrolase PF06821.11 NM_022419.3_3 - 0.13 12.0 0.0 13 5.4 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase DLH PF01738.16 NM_022419.3_3 - 0.19 11.1 0.0 16 4.8 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF4663 PF15668.3 NM_022419.3_3 - 0.2 10.6 0.6 0.3 10.0 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) ERG4_ERG24 PF01222.15 NM_133815.2_3 - 5.1e-157 522.9 1.8 7.6e-157 522.3 1.8 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family LBR_tudor PF09465.8 NM_133815.2_3 - 1.3e-30 104.9 0.4 2.1e-30 104.2 0.4 1.4 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain DUF1295 PF06966.10 NM_133815.2_3 - 4.1e-06 26.4 0.2 7.7e-06 25.5 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.12 NM_133815.2_3 - 0.0033 17.7 2.1 0.0061 16.8 0.1 2.3 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family MAJIN PF15077.4 NM_133815.2_3 - 0.98 9.1 4.5 0.79 9.4 3.1 1.5 1 1 0 1 1 1 0 Membrane-anchored junction protein Corona_nucleoca PF00937.16 NM_133815.2_3 - 2.4 7.0 7.1 3.5 6.4 7.1 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein LRR_4 PF12799.5 NM_028149.1_2 - 1e-13 51.0 10.0 0.13 12.6 0.0 6.7 6 0 0 6 6 6 5 Leucine Rich repeats (2 copies) F-box-like PF12937.5 NM_028149.1_2 - 9.7e-12 44.5 0.6 9.7e-12 44.5 0.6 2.7 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.4 NM_028149.1_2 - 3.5e-10 39.0 20.4 0.026 14.5 0.1 8.3 10 0 0 10 10 10 4 Leucine Rich repeat F-box PF00646.31 NM_028149.1_2 - 1.9e-06 27.5 0.7 1.9e-06 27.5 0.7 2.4 2 0 0 2 2 2 1 F-box domain LRR_8 PF13855.4 NM_028149.1_2 - 0.0074 15.9 0.7 2.5 7.8 0.1 3.7 3 0 0 3 3 3 1 Leucine rich repeat F-box_4 PF15966.3 NM_028149.1_2 - 0.034 13.9 0.0 0.094 12.5 0.0 1.7 1 0 0 1 1 1 0 F-box RRM_1 PF00076.20 NM_001109913.1_2 - 3.8e-53 177.0 0.1 6.5e-19 67.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M PF11532.6 NM_001109913.1_2 - 6.5e-19 67.7 10.5 1.3e-18 66.7 10.5 1.6 1 0 0 1 1 1 1 Heterogeneous nuclear ribonucleoprotein M RRM_5 PF13893.4 NM_001109913.1_2 - 6e-05 22.5 0.5 0.045 13.2 0.0 3.2 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 NM_001109913.1_2 - 0.0001 22.2 0.2 0.0094 15.9 0.0 2.6 2 1 0 2 2 2 1 Limkain b1 Collagen_mid PF15984.3 NM_001109913.1_2 - 0.00014 21.5 0.0 0.00014 21.5 0.0 2.9 2 1 1 3 3 3 1 Bacterial collagen, middle region RRM_occluded PF16842.3 NM_001109913.1_2 - 0.002 17.8 0.0 0.13 12.1 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif XS PF03468.12 NM_001109913.1_2 - 0.029 14.5 0.1 26 5.0 0.0 3.1 3 0 0 3 3 3 0 XS domain I-set PF07679.14 NM_172290.3_3 - 1.6e-41 140.1 1.1 4.1e-14 52.3 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_172290.3_3 - 1.9e-38 130.8 5.0 1.2e-14 54.5 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_172290.3_3 - 2.2e-32 110.9 3.5 1.6e-14 53.7 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 NM_172290.3_3 - 3.3e-30 104.1 2.5 1.8e-11 44.1 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_172290.3_3 - 5.6e-15 55.3 7.6 5.8e-08 32.7 0.7 5.5 3 3 1 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_172290.3_3 - 1.1e-08 35.3 0.4 0.035 14.4 0.0 3.9 3 2 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 NM_172290.3_3 - 3.7e-06 26.7 0.2 0.023 14.6 0.2 4.0 3 1 0 3 3 3 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 NM_172290.3_3 - 0.0013 18.7 0.1 0.51 10.3 0.0 2.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.9 NM_172290.3_3 - 0.027 14.3 0.6 3.4 7.5 0.1 2.8 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain MRG PF05712.11 NM_001168225.1_3 - 3e-52 176.7 0.2 4.4e-52 176.1 0.2 1.2 1 0 0 1 1 1 1 MRG zf-LITAF-like PF10601.7 NM_001324517.1_3 - 6.9e-21 74.2 14.1 9e-21 73.8 14.1 1.1 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Zn_Tnp_IS1595 PF12760.5 NM_001324517.1_3 - 0.0057 16.5 1.8 0.47 10.3 0.1 2.2 2 0 0 2 2 2 2 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.10 NM_001324517.1_3 - 0.21 11.5 3.5 0.94 9.4 0.8 2.4 2 0 0 2 2 2 0 PhnA Zinc-Ribbon Chon_Sulph_att PF06566.9 NM_001166273.1_1 - 1.2e-119 398.6 21.4 2.2e-119 397.8 21.4 1.4 1 0 0 1 1 1 1 Chondroitin sulphate attachment domain Neural_ProG_Cyt PF06567.9 NM_001166273.1_1 - 2.3e-69 231.0 0.6 3.6e-69 230.3 0.6 1.3 1 0 0 1 1 1 1 Neural chondroitin sulphate proteoglycan cytoplasmic domain I-set PF07679.14 NM_001164259.1_3 - 3.6e-27 94.1 0.0 9.1e-17 60.8 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001164259.1_3 - 3.2e-26 91.6 0.8 1e-14 54.7 0.0 2.6 3 0 0 3 3 2 2 Immunoglobulin domain ig PF00047.23 NM_001164259.1_3 - 4.7e-22 77.8 0.1 9.1e-12 44.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_001164259.1_3 - 3.6e-15 55.9 0.0 6.5e-11 42.3 0.0 3.1 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_001164259.1_3 - 1.8e-12 47.2 0.0 0.00086 19.3 0.0 3.3 2 1 1 3 3 3 3 Immunoglobulin V-set domain Receptor_2B4 PF11465.6 NM_001164259.1_3 - 0.00029 20.9 0.0 0.079 13.0 0.0 2.2 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_5 PF16681.3 NM_001164259.1_3 - 0.00063 20.0 0.1 0.0028 17.9 0.0 2.0 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 NM_001164259.1_3 - 0.00084 19.2 0.1 0.0031 17.4 0.0 2.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 NM_001164259.1_3 - 0.0036 17.5 0.2 0.081 13.2 0.0 2.6 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 NM_001164259.1_3 - 0.095 12.6 0.0 0.73 9.8 0.0 2.0 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain C1-set PF07654.13 NM_001164259.1_3 - 0.11 12.8 0.1 0.31 11.4 0.0 1.7 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Guanylate_cyc PF00211.18 NM_007406.2_3 - 1.6e-119 396.1 0.0 5.4e-62 208.5 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.12 NM_007406.2_3 - 1.1e-32 112.5 0.0 1.8e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) AC_N PF16214.3 NM_007406.2_3 - 1.3e-16 60.7 11.0 1.3e-16 60.7 11.0 2.0 3 0 0 3 3 3 1 Adenylyl cyclase N-terminal extracellular and transmembrane region zf-H2C2_2 PF13465.4 NM_001161818.1_3 - 1.4e-12 47.3 42.6 7.6e-05 22.9 0.1 9.7 9 0 0 9 9 9 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001161818.1_3 - 3.8e-12 45.8 56.9 0.038 14.3 2.9 10.2 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001161818.1_3 - 3.7e-11 42.7 59.2 0.069 13.9 0.9 10.6 10 0 0 10 10 10 5 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_001161818.1_3 - 6.1e-09 35.3 44.6 0.00047 19.7 0.3 7.6 8 0 0 8 8 8 3 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.3 NM_001161818.1_3 - 0.24 12.0 30.8 0.52 11.0 3.4 5.2 4 1 1 5 5 5 0 zinc-ribbon family zf-C2H2_8 PF15909.3 NM_001161818.1_3 - 0.26 11.5 29.1 0.13 12.4 3.0 5.2 2 2 4 6 6 6 0 C2H2-type zinc ribbon DZR PF12773.5 NM_001161818.1_3 - 0.8 9.6 19.6 7.5 6.5 0.7 4.8 3 1 1 4 4 4 0 Double zinc ribbon CarbpepA_inh PF02977.13 NM_001161818.1_3 - 1.5 8.6 7.5 14 5.5 0.1 4.0 4 0 0 4 4 4 0 Carboxypeptidase A inhibitor Vault PF01505.16 NM_010837.3_3 - 0.0097 16.0 9.9 16 5.8 0.2 4.6 4 0 0 4 4 4 4 Major Vault Protein repeat SAGA-Tad1 PF12767.5 NM_010837.3_3 - 4.3 6.9 8.0 13 5.3 8.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Hydrolase_4 PF12146.6 NM_145421.2_1 - 2.1e-14 53.2 0.0 9.9e-08 31.4 0.0 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 NM_145421.2_1 - 6.3e-08 32.4 0.3 0.0033 17.0 0.4 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_145421.2_1 - 5.2e-06 26.0 0.0 0.00015 21.2 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.5 NM_145421.2_1 - 0.00047 20.7 0.0 0.00047 20.7 0.0 3.1 2 2 1 3 3 2 1 Alpha/beta hydrolase family DLH PF01738.16 NM_145421.2_1 - 0.0022 17.5 0.0 0.0034 16.8 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.11 NM_145421.2_1 - 0.0024 17.5 0.0 0.0036 16.9 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) UPF0227 PF05728.10 NM_145421.2_1 - 0.01 15.6 0.0 0.078 12.8 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Abhydrolase_5 PF12695.5 NM_145421.2_1 - 0.025 14.2 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF818 PF05677.10 NM_145421.2_1 - 0.027 13.3 0.1 0.041 12.7 0.1 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Abhydrolase_2 PF02230.14 NM_145421.2_1 - 0.031 13.9 0.0 0.12 12.0 0.0 1.9 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Asp2 PF16929.3 NM_145421.2_1 - 0.058 12.3 0.0 0.081 11.8 0.0 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Septin PF00735.16 NM_017461.2_1 - 1.1e-121 405.3 0.0 1.4e-121 404.9 0.0 1.1 1 0 0 1 1 1 1 Septin DUF258 PF03193.14 NM_017461.2_1 - 1.9e-08 34.2 0.2 1.9e-06 27.8 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 NM_017461.2_1 - 3.4e-08 33.4 0.0 7.5e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 NM_017461.2_1 - 5e-07 29.3 0.3 0.018 14.5 0.0 2.7 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain AAA_23 PF13476.4 NM_017461.2_1 - 0.00085 19.8 0.0 0.0076 16.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AIG1 PF04548.14 NM_017461.2_1 - 0.0043 16.3 0.0 0.0097 15.1 0.0 1.6 1 0 0 1 1 1 1 AIG1 family AAA_22 PF13401.4 NM_017461.2_1 - 0.02 15.1 0.6 0.13 12.4 0.0 2.5 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.4 NM_017461.2_1 - 0.02 15.1 0.5 0.083 13.1 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.4 NM_017461.2_1 - 0.034 13.7 0.0 0.063 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.11 NM_017461.2_1 - 0.042 14.0 0.0 0.09 12.9 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_017461.2_1 - 0.067 12.6 0.0 0.19 11.2 0.0 1.7 1 0 0 1 1 1 0 Ras family ABC_tran PF00005.25 NM_017461.2_1 - 0.069 13.5 0.1 0.2 12.0 0.0 1.8 2 0 0 2 2 2 0 ABC transporter Pet20 PF08692.8 NM_017461.2_1 - 0.084 13.5 0.2 0.47 11.0 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial protein Pet20 IIGP PF05049.11 NM_017461.2_1 - 0.26 10.2 0.0 0.26 10.2 0.0 1.8 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) Dynamin_N PF00350.21 NM_017461.2_1 - 0.82 9.6 6.9 9.6 6.1 0.2 3.4 3 1 1 4 4 4 0 Dynamin family SUIM_assoc PF16619.3 NM_017461.2_1 - 2.5 8.1 5.1 7.5 6.6 5.1 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF4694 PF15765.3 NM_001145759.1_3 - 4.8e-22 78.5 4.7 8e-22 77.8 4.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4694) DUF4174 PF13778.4 NM_026838.4_3 - 6.3e-33 113.6 0.2 9e-33 113.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4174) HYR PF02494.14 NM_026838.4_3 - 1.2e-28 99.1 0.0 2.1e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 HYR domain Sushi PF00084.18 NM_026838.4_3 - 8.4e-22 77.4 25.1 5.2e-10 39.7 6.3 3.8 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) La PF05383.15 NM_001040399.1_3 - 1.5e-22 79.2 0.2 5.6e-22 77.4 0.1 2.0 2 0 0 2 2 2 1 La domain DUF4551 PF15087.4 NM_001040399.1_3 - 3.1 6.4 11.8 4.7 5.8 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) BEX PF04538.10 NM_177919.2_3 - 1.1e-40 139.0 33.9 1.1e-38 132.5 33.9 2.1 1 1 0 1 1 1 1 Brain expressed X-linked like family Mtc PF03820.15 NM_053196.3_1 - 1.4e-134 448.0 1.9 1.7e-134 447.7 1.9 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier 7tm_4 PF13853.4 NM_146326.3_3 - 3.1e-54 184.4 23.0 4e-54 184.1 23.0 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146326.3_3 - 1.1e-23 83.7 23.5 1.9e-23 83.0 23.5 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 NM_146326.3_3 - 0.00011 21.6 14.4 0.00011 21.6 14.4 2.2 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv AA_permease_2 PF13520.4 NM_001253680.1_1 - 1.2e-61 208.7 42.3 1.5e-61 208.4 42.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 NM_001253680.1_1 - 2.7e-25 88.8 35.3 3.9e-25 88.2 35.3 1.2 1 0 0 1 1 1 1 Amino acid permease Integrin_alpha2 PF08441.10 NM_133721.2_1 - 8.7e-91 305.0 0.0 1.3e-90 304.4 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 NM_133721.2_1 - 1.1e-23 82.9 16.0 2.6e-10 40.1 0.0 4.6 4 0 0 4 4 4 3 FG-GAP repeat VCBS PF13517.4 NM_133721.2_1 - 8e-10 39.0 3.8 1.3e-07 32.0 1.1 2.9 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 NM_133721.2_1 - 0.0022 17.7 0.2 0.0064 16.3 0.2 1.9 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.4 NM_133721.2_1 - 0.011 15.9 8.5 0.041 14.0 0.5 4.2 4 0 0 4 4 4 0 FG-GAP repeat Na_sulph_symp PF00939.17 NM_019481.2_2 - 1.1e-97 328.0 28.8 1.3e-97 327.7 28.8 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.14 NM_019481.2_2 - 1.1e-25 90.3 51.4 1.1e-12 47.7 9.3 3.2 2 1 1 3 3 3 3 Citrate transporter MAPKK1_Int PF08923.8 NM_019920.2_3 - 3.8e-48 162.1 0.0 5.6e-48 161.5 0.0 1.2 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting 7tm_1 PF00001.19 NM_001310430.1_1 - 1.3e-44 152.3 19.2 1.8e-44 151.8 19.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 NM_001310430.1_1 - 0.00095 18.4 14.8 0.0015 17.8 14.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx V-set_2 PF15910.3 NM_017480.2_1 - 1.1e-54 183.2 0.3 2e-54 182.4 0.3 1.5 1 0 0 1 1 1 1 ICOS V-set domain HlyIII PF03006.18 NM_028748.2_2 - 7.8e-56 189.2 17.1 1.3e-55 188.4 17.1 1.4 1 0 0 1 1 1 1 Haemolysin-III related Defensin_propep PF00879.16 NM_007849.1_1 - 6.3e-21 74.3 0.1 8.2e-21 74.0 0.1 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 NM_007849.1_1 - 4.6e-08 33.3 15.5 6.3e-08 32.9 15.5 1.2 1 0 0 1 1 1 1 Mammalian defensin MF_alpha_N PF05436.9 NM_007849.1_1 - 0.024 14.4 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus Pkinase PF00069.23 NM_001195496.1_1 - 1.1e-71 241.2 0.0 1.6e-71 240.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DCX PF03607.15 NM_001195496.1_1 - 4.5e-43 145.0 0.2 1.1e-22 79.7 0.0 2.5 2 0 0 2 2 2 2 Doublecortin Pkinase_Tyr PF07714.15 NM_001195496.1_1 - 1.6e-32 112.7 0.0 2.2e-32 112.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001195496.1_1 - 2.4e-05 23.7 0.0 0.00012 21.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 NM_001195496.1_1 - 0.0091 15.2 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family GTF2I PF02946.12 NM_001081468.2_2 - 5.9e-158 513.1 11.5 1.3e-31 108.3 0.1 6.3 6 0 0 6 6 6 6 GTF2I-like repeat AAA_25 PF13481.4 NM_001081468.2_2 - 0.034 13.6 0.0 8.8 5.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF4806 PF16064.3 NM_001081468.2_2 - 0.035 14.3 0.0 35 4.7 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4806) Bax1-I PF01027.18 NM_029141.4_1 - 6.6e-34 117.4 29.1 8.2e-34 117.1 29.1 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.5 NM_029141.4_1 - 2e-07 30.7 14.7 2.9e-07 30.2 14.7 1.2 1 0 0 1 1 1 1 Bax inhibitor 1 like UcrQ PF02939.14 NM_001326614.1_1 - 7e-31 105.9 0.1 1e-30 105.4 0.1 1.2 1 0 0 1 1 1 1 UcrQ family NUT PF12881.5 NM_001033400.2_2 - 1.4e-273 909.7 15.6 1.9e-273 909.2 15.6 1.2 1 0 0 1 1 1 1 NUT protein LIM PF00412.20 NM_021318.3_2 - 3.3e-46 155.2 71.0 1.3e-11 44.4 6.3 5.1 5 0 0 5 5 5 5 LIM domain TNFR_c6 PF00020.16 NM_021318.3_2 - 0.49 10.7 0.1 0.49 10.7 0.1 9.4 9 3 0 9 9 9 0 TNFR/NGFR cysteine-rich region Sulfotransfer_1 PF00685.25 NM_178870.5_1 - 3.2e-44 151.3 0.0 4.4e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_178870.5_1 - 1.8e-16 61.1 0.0 1.4e-11 45.1 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family Apo-CIII PF05778.10 NM_001289756.1_3 - 2e-34 116.9 0.2 2.6e-34 116.5 0.2 1.1 1 0 0 1 1 1 1 Apolipoprotein CIII (Apo-CIII) CLPTM1 PF05602.10 NM_019649.2_2 - 1.4e-146 488.8 0.0 1.7e-146 488.5 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.12 NM_019649.2_2 - 0.17 11.6 2.7 1.4 8.6 0.2 2.7 2 0 0 2 2 2 0 PQ loop repeat AMPK1_CBM PF16561.3 NM_182997.2_1 - 7.5e-35 118.9 0.1 1.2e-34 118.3 0.1 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.13 NM_182997.2_1 - 1.9e-26 92.0 3.8 3.9e-26 91.0 3.8 1.5 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.16 NM_182997.2_1 - 0.025 14.8 0.0 0.046 14.0 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) RabGAP-TBC PF00566.16 NM_144517.4_2 - 1.5e-14 54.0 6.7 2.1e-13 50.3 6.7 2.1 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF4604 PF15377.4 NM_001159908.1_1 - 4.4 7.6 19.1 6 7.2 19.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) zf-AN1 PF01428.14 NM_001159908.1_2 - 7.7e-21 73.9 28.0 1.7e-10 40.8 9.2 3.6 2 0 0 2 2 2 2 AN1-like Zinc finger Transp_Tc5_C PF04236.13 NM_001159908.1_2 - 0.45 10.8 20.2 1.2 9.4 5.1 2.7 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain DUF4604 PF15377.4 NM_001159908.1_2 - 1.4 9.2 17.8 2.2 8.5 17.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) RNA_polI_A34 PF08208.9 NM_001159908.1_2 - 5.8 6.8 24.2 8.5 6.3 24.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF3464 PF11947.6 NM_001159908.1_2 - 8.7 6.0 8.1 14 5.3 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) DUF4604 PF15377.4 NM_001159908.1_3 - 4.9 7.4 18.7 7 6.9 18.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) BRF1 PF07741.11 NM_001159908.1_3 - 8.9 6.6 17.2 14 6.0 17.2 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Oxysterol_BP PF01237.16 NM_001033174.1_2 - 1.1e-146 488.3 0.4 1.8e-146 487.6 0.4 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 NM_001033174.1_2 - 1.5e-15 57.4 0.1 3.5e-15 56.2 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 NM_001033174.1_2 - 2e-11 43.9 0.3 3.9e-11 42.9 0.3 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.4 NM_001033174.1_2 - 3.6e-05 23.9 0.0 0.00012 22.2 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.4 NM_001033174.1_2 - 8.6e-05 22.8 4.0 0.0051 17.1 4.0 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain betaPIX_CC PF16523.3 NM_001033174.1_2 - 0.06 13.0 0.4 0.17 11.6 0.4 1.7 1 0 0 1 1 1 0 betaPIX coiled coil Syntaxin-6_N PF09177.9 NM_001033174.1_2 - 0.26 11.7 3.4 1.1 9.7 1.9 2.4 2 0 0 2 2 2 0 Syntaxin 6, N-terminal 7tm_4 PF13853.4 NM_146374.1_1 - 6e-45 154.0 8.7 7.8e-45 153.6 8.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146374.1_1 - 1.9e-16 60.0 11.4 3.2e-16 59.2 11.4 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146374.1_1 - 0.02 14.1 11.4 0.098 11.9 11.4 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx nlz1 PF12402.6 NM_001101502.1_1 - 1.2e-20 73.5 9.9 1.2e-20 73.5 9.9 3.9 3 0 0 3 3 3 1 NocA-like zinc-finger protein 1 zf-C2H2 PF00096.24 NM_001101502.1_1 - 0.012 15.9 0.1 0.036 14.4 0.1 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001101502.1_1 - 0.063 14.0 0.1 0.25 12.1 0.1 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger SCAN PF02023.15 NM_172941.4_1 - 7.6e-39 131.3 2.9 1.4e-38 130.5 2.9 1.5 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 NM_172941.4_1 - 5.7e-16 57.9 46.3 0.00037 20.7 2.5 6.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_172941.4_1 - 3.3e-11 42.9 36.9 0.0077 16.9 1.5 6.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_172941.4_1 - 2.1e-07 30.9 42.5 0.0037 17.5 0.2 7.3 8 0 0 8 8 7 4 Zinc-finger double domain KRAB PF01352.25 NM_172941.4_1 - 1.3e-05 24.6 0.0 2.6e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 KRAB box ADK_lid PF05191.12 NM_172941.4_1 - 0.003 17.4 2.5 0.018 14.9 0.4 2.8 2 0 0 2 2 2 1 Adenylate kinase, active site lid DUF2039 PF10217.7 NM_172941.4_1 - 0.0066 16.6 0.3 0.0066 16.6 0.3 2.5 3 0 0 3 3 2 1 Uncharacterized conserved protein (DUF2039) zinc_ribbon_15 PF17032.3 NM_172941.4_1 - 0.009 16.6 12.7 0.024 15.2 2.0 3.5 2 1 1 3 3 3 1 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_172941.4_1 - 0.016 15.4 12.0 5.8 7.2 0.0 5.3 4 1 1 5 5 5 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.3 NM_172941.4_1 - 0.03 14.8 9.9 0.43 11.1 4.8 3.2 2 1 1 3 3 3 0 FOXP coiled-coil domain CpXC PF14353.4 NM_172941.4_1 - 0.044 13.7 10.6 1.1 9.2 0.1 3.9 1 1 3 4 4 4 0 CpXC protein zf-C2H2_6 PF13912.4 NM_172941.4_1 - 0.051 13.4 34.3 0.095 12.5 0.2 5.7 5 1 0 5 5 5 0 C2H2-type zinc finger C1_1 PF00130.20 NM_172941.4_1 - 0.097 12.4 0.0 0.097 12.4 0.0 3.8 2 2 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.8 NM_172941.4_1 - 0.18 11.8 18.2 0.079 13.0 0.3 4.8 4 1 0 4 4 4 0 Zinc ribbon domain FYDLN_acid PF09538.8 NM_172941.4_1 - 0.27 11.8 4.1 2.2 8.8 0.1 3.5 1 1 3 4 4 3 0 Protein of unknown function (FYDLN_acid) HypA PF01155.17 NM_172941.4_1 - 0.38 10.6 9.6 12 5.9 0.8 3.5 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-met PF12874.5 NM_172941.4_1 - 1.1 9.6 16.8 7.9 6.9 0.9 4.5 4 0 0 4 4 4 0 Zinc-finger of C2H2 type TF_Zn_Ribbon PF08271.10 NM_172941.4_1 - 2.9 7.4 4.5 16 5.0 0.1 3.2 2 1 0 2 2 2 0 TFIIB zinc-binding zf-ribbon_3 PF13248.4 NM_172941.4_1 - 3.3 7.1 6.2 5.9 6.3 0.1 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Pro_isomerase PF00160.19 NM_008908.4_1 - 7.6e-47 159.4 0.1 9.9e-47 159.0 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Aminotran_5 PF00266.17 NM_016702.3_1 - 2.8e-62 210.7 0.0 3.3e-62 210.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.19 NM_016702.3_1 - 0.0035 16.4 0.0 0.037 13.1 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class I and II Aldedh PF00171.20 NM_138600.4_3 - 7.3e-129 430.1 0.0 9e-129 429.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family FoP_duplication PF13865.4 NM_001293778.1_2 - 4.3e-21 75.1 6.6 4.3e-21 75.1 6.6 2.1 2 1 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 Sbi-IV PF11621.6 NM_001293778.1_2 - 8.7 6.7 8.3 26 5.1 0.0 3.7 2 2 2 4 4 4 0 C3 binding domain 4 of IgG-bind protein SBI V1R PF03402.12 NM_001166753.1_1 - 5.7e-15 55.5 10.5 7.6e-15 55.1 10.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001166753.1_1 - 7.5e-15 54.7 13.0 9.4e-15 54.4 13.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001166753.1_1 - 6.3e-06 25.5 12.9 8.5e-06 25.1 12.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1700 PF08006.9 NM_001166753.1_1 - 0.086 12.2 3.2 0.14 11.6 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Fer4 PF00037.25 NM_001166753.1_3 - 0.31 10.8 6.4 0.58 9.9 1.2 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_4 PF12800.5 NM_001166753.1_3 - 0.67 10.5 0.1 0.67 10.5 0.1 3.6 3 0 0 3 3 3 0 4Fe-4S binding domain Pkinase PF00069.23 NM_001271566.1_2 - 2.8e-45 154.6 0.0 1.5e-25 89.9 0.2 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001271566.1_2 - 8.8e-16 57.8 0.0 5.8e-13 48.6 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.21 NM_001271566.1_2 - 0.034 13.9 0.0 1.4 8.7 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Peptidase_C74 PF12387.6 NM_001271566.1_3 - 0.013 14.9 1.2 0.02 14.2 1.2 1.2 1 0 0 1 1 1 0 Pestivirus NS2 peptidase PDZ PF00595.22 NM_001198985.1_1 - 1.3e-44 150.2 6.2 5e-15 55.5 0.2 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001198985.1_1 - 6e-16 58.4 2.5 0.00028 21.0 0.1 3.5 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.19 NM_001198985.1_1 - 6.2e-11 42.2 0.0 1.3e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.15 NM_001198985.1_1 - 8.3e-08 31.7 0.4 8.9e-07 28.4 0.0 3.0 4 0 0 4 4 4 1 Variant SH3 domain SH3_1 PF00018.26 NM_001198985.1_1 - 0.00047 19.6 0.0 0.0038 16.7 0.0 2.6 2 0 0 2 2 2 1 SH3 domain 7tm_4 PF13853.4 NM_207560.1_1 - 1.3e-53 182.4 24.2 1.6e-53 182.1 24.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207560.1_1 - 4e-21 75.3 24.8 7e-21 74.5 24.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_207560.1_1 - 3.2e-06 26.6 24.4 4.6e-06 26.1 24.1 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx RCC1 PF00415.16 NM_001177951.1_1 - 6.8e-67 221.8 11.2 7.3e-11 42.4 0.0 7.9 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 NM_001177951.1_1 - 4.8e-29 99.4 34.1 5e-09 35.6 0.0 8.4 9 1 0 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.4 NM_001177951.1_1 - 0.0017 18.1 9.1 0.19 11.6 0.9 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_001177951.1_1 - 0.074 12.9 0.0 37 4.4 0.0 3.8 3 0 0 3 3 3 0 Kelch motif Abi_HHR PF07815.12 NM_025659.4_3 - 1.6e-27 95.3 0.0 3e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.4 NM_025659.4_3 - 5e-12 45.3 0.3 1.2e-11 44.1 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 NM_025659.4_3 - 3.1e-09 36.2 0.0 5.7e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_025659.4_3 - 5.5e-08 32.2 0.1 1.1e-07 31.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain AAA_2 PF07724.12 NM_001044389.2_3 - 5.1e-41 140.5 0.0 8.3e-41 139.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.7 NM_001044389.2_3 - 2.7e-14 52.8 0.1 5.9e-14 51.8 0.1 1.6 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.27 NM_001044389.2_3 - 1.9e-13 50.9 0.0 3.4e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 NM_001044389.2_3 - 2.3e-05 24.3 0.0 5.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.24 NM_001044389.2_3 - 3.9e-05 23.3 0.0 0.00024 20.7 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.19 NM_001044389.2_3 - 9.4e-05 21.7 0.5 0.016 14.4 0.0 3.2 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.4 NM_001044389.2_3 - 0.00049 20.3 0.1 0.002 18.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 NM_001044389.2_3 - 0.0055 17.0 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Sigma54_activ_2 PF14532.4 NM_001044389.2_3 - 0.0096 15.9 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain T2SSE PF00437.18 NM_001044389.2_3 - 0.01 14.8 0.0 0.016 14.1 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.4 NM_001044389.2_3 - 0.011 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.15 NM_001044389.2_3 - 0.011 15.3 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RuvB_N PF05496.10 NM_001044389.2_3 - 0.013 14.6 0.0 0.027 13.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus TsaE PF02367.15 NM_001044389.2_3 - 0.031 14.1 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.10 NM_001044389.2_3 - 0.051 13.4 0.3 0.12 12.2 0.3 1.7 1 1 0 1 1 1 0 NACHT domain AAA_24 PF13479.4 NM_001044389.2_3 - 0.097 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.4 NM_001044389.2_3 - 0.12 12.8 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain zinc_ribbon_4 PF13717.4 NM_001044389.2_3 - 0.47 10.3 4.9 13 5.6 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.5 NM_001044389.2_3 - 0.52 10.2 4.6 1.4 8.9 4.6 1.7 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF737 PF05300.9 NM_025336.1_1 - 4.1e-45 154.5 37.8 3e-32 112.5 29.6 2.4 2 1 1 3 3 3 2 Protein of unknown function (DUF737) CHCH PF06747.11 NM_025336.1_1 - 0.00025 20.9 3.0 0.00047 20.1 3.0 1.4 1 0 0 1 1 1 1 CHCH domain NDUF_B7 PF05676.11 NM_025336.1_1 - 0.064 12.9 4.1 0.24 11.0 4.1 2.0 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF1690 PF07956.9 NM_025336.1_1 - 0.5 10.6 23.2 2.2 8.6 10.9 2.3 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) ECH_2 PF16113.3 NM_025336.1_1 - 0.5 9.7 6.4 0.72 9.2 6.4 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase zf-H2C2_2 PF13465.4 NM_183167.4_2 - 3e-78 254.9 91.6 1.2e-08 34.9 0.5 13.6 13 0 0 13 13 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_183167.4_2 - 8.3e-47 155.0 99.0 2.1e-05 24.6 2.5 12.6 12 0 0 12 12 12 10 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_183167.4_2 - 3.3e-24 84.2 74.4 0.001 18.8 2.9 12.1 12 1 0 12 12 11 9 C2H2-type zinc finger zf-C2H2_4 PF13894.4 NM_183167.4_2 - 5.6e-20 70.2 99.0 0.0063 17.1 2.8 12.4 13 0 0 13 13 12 9 C2H2-type zinc finger KRAB PF01352.25 NM_183167.4_2 - 6.4e-20 70.4 0.0 1.1e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_183167.4_2 - 1.1e-07 31.7 52.0 0.014 15.3 2.9 7.7 5 3 2 8 8 7 6 Zinc ribbon domain XPA_N PF01286.16 NM_183167.4_2 - 1.2e-05 25.1 31.8 0.84 9.6 0.2 9.4 9 0 0 9 9 9 2 XPA protein N-terminal GATA PF00320.25 NM_183167.4_2 - 2e-05 24.0 26.5 0.62 9.6 0.2 7.6 7 1 0 7 7 7 3 GATA zinc finger DUF3268 PF11672.6 NM_183167.4_2 - 0.00058 20.1 30.8 0.087 13.0 1.5 5.8 2 1 4 7 7 7 4 zinc-finger-containing domain C1_4 PF07975.10 NM_183167.4_2 - 0.0015 18.7 42.9 1.7 8.9 4.8 7.6 2 1 5 8 8 8 3 TFIIH C1-like domain SprT-like PF10263.7 NM_183167.4_2 - 0.042 13.5 66.8 0.8 9.4 4.3 5.7 2 1 1 4 4 3 0 SprT-like family BHD_1 PF10403.7 NM_183167.4_2 - 0.058 13.1 0.4 1.1 9.1 0.1 2.5 2 0 0 2 2 2 0 Rad4 beta-hairpin domain 1 zf-C2H2_jaz PF12171.6 NM_183167.4_2 - 0.095 12.9 66.5 0.2 11.9 0.6 10.6 11 0 0 11 11 10 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_183167.4_2 - 0.54 10.9 46.8 1 10.0 1.4 5.9 4 2 3 7 7 6 0 zinc-ribbon family HypA PF01155.17 NM_183167.4_2 - 0.7 9.8 34.3 5 7.0 1.5 5.7 1 1 4 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ZZ PF00569.15 NM_183167.4_2 - 1 9.1 37.0 16 5.2 0.3 9.1 9 0 0 9 9 9 0 Zinc finger, ZZ type zf-C2H2_11 PF16622.3 NM_183167.4_2 - 1.5 8.5 44.2 2 8.1 0.5 10.2 10 0 0 10 10 10 0 zinc-finger C2H2-type TFIIS_C PF01096.16 NM_183167.4_2 - 2.5 7.9 42.2 0.026 14.2 2.9 7.7 7 1 0 7 7 7 0 Transcription factor S-II (TFIIS) CpXC PF14353.4 NM_183167.4_2 - 2.6 7.9 37.4 10 6.0 0.2 8.6 5 3 2 8 8 8 0 CpXC protein zf-LYAR PF08790.9 NM_183167.4_2 - 6.1 6.7 40.3 6.6 6.6 0.3 10.0 10 0 0 10 10 10 0 LYAR-type C2HC zinc finger U-box PF04564.13 NM_183167.4_3 - 0.3 11.2 3.2 31 4.7 0.1 3.8 4 0 0 4 4 4 0 U-box domain SWIB PF02201.16 NM_183167.4_3 - 1.3 8.8 7.3 5.7 6.8 0.0 4.8 6 0 0 6 6 6 0 SWIB/MDM2 domain Ion_trans PF00520.29 NM_010601.3_1 - 2.4e-32 112.0 0.2 3.1e-32 111.6 0.2 1.1 1 0 0 1 1 1 1 Ion transport protein PAS_9 PF13426.5 NM_010601.3_1 - 4.1e-18 65.4 0.0 9.5e-18 64.2 0.0 1.6 1 0 0 1 1 1 1 PAS domain Ion_trans_2 PF07885.14 NM_010601.3_1 - 2.2e-11 43.4 1.1 1.3e-10 41.0 1.0 2.3 2 0 0 2 2 2 1 Ion channel cNMP_binding PF00027.27 NM_010601.3_1 - 2e-07 30.8 0.0 4.9e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PAS_4 PF08448.8 NM_010601.3_1 - 1.3e-06 28.5 0.0 2.7e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.10 NM_010601.3_1 - 3.5e-06 27.1 0.0 5.8e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS PF00989.23 NM_010601.3_1 - 8.2e-06 25.7 0.0 1.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 PAS fold S6PP PF05116.11 NM_010601.3_1 - 0.071 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase TTD PF12148.6 NM_144873.2_3 - 6.3e-63 211.2 0.2 6.3e-63 211.2 0.2 1.7 2 0 0 2 2 2 1 Tandem tudor domain within UHRF1 SAD_SRA PF02182.15 NM_144873.2_3 - 2e-48 163.7 0.1 4.7e-48 162.5 0.0 1.7 2 0 0 2 2 2 1 SAD/SRA domain ubiquitin PF00240.21 NM_144873.2_3 - 9e-14 50.8 0.0 2.1e-13 49.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family PHD PF00628.27 NM_144873.2_3 - 6.7e-09 35.4 12.5 6.7e-09 35.4 12.5 3.8 2 2 1 3 3 3 1 PHD-finger zf-C3HC4_2 PF13923.4 NM_144873.2_3 - 7e-05 22.5 14.0 7e-05 22.5 14.0 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_144873.2_3 - 0.00013 21.6 11.3 0.00013 21.6 11.3 4.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_144873.2_3 - 0.0017 18.1 13.5 0.0017 18.1 13.5 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_144873.2_3 - 0.0069 16.1 11.0 0.0069 16.1 11.0 3.1 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 NM_144873.2_3 - 9.3 6.2 35.1 0.013 15.3 14.6 3.3 2 1 1 3 3 3 0 zinc-RING finger domain Pkinase_Tyr PF07714.15 NM_001190975.1_1 - 3.2e-89 298.5 0.0 4.2e-89 298.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001190975.1_1 - 1.4e-36 126.1 0.0 1.9e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.4 NM_001190975.1_1 - 2.4e-16 60.0 0.9 1.3e-07 32.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 NM_001190975.1_1 - 6.3e-13 48.7 0.0 3.7e-06 27.1 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001190975.1_1 - 9.6e-11 41.6 2.0 2.2e-06 27.6 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 NM_001190975.1_1 - 4.8e-09 36.0 0.0 2.3e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain fn3 PF00041.19 NM_001190975.1_1 - 1.3e-06 28.5 0.0 2.6e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain V-set PF07686.15 NM_001190975.1_1 - 0.00016 21.7 0.0 0.00044 20.3 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin V-set domain C1-set PF07654.13 NM_001190975.1_1 - 0.0051 17.1 0.0 0.058 13.7 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin C1-set domain DUF4381 PF14316.4 NM_001190975.1_1 - 0.025 14.7 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF3915 PF13054.4 NM_001190975.1_1 - 2.3 8.1 9.4 4.4 7.2 9.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Collagen PF01391.16 NM_015734.2_2 - 1.4e-158 514.7 717.3 2.6e-08 33.4 24.7 23.0 4 1 14 18 18 18 14 Collagen triple helix repeat (20 copies) COLFI PF01410.16 NM_015734.2_2 - 5.7e-97 323.5 0.0 7.4e-97 323.1 0.0 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Laminin_G_2 PF02210.22 NM_015734.2_2 - 5.4e-05 23.6 0.0 9.6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 NM_015734.2_2 - 0.036 14.2 0.0 0.065 13.3 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain Nebulin PF00880.16 NM_028757.2_1 - 4.4e-28 96.7 1.7 5.4e-12 45.3 0.1 3.5 3 0 0 3 3 3 3 Nebulin repeat SH3_9 PF14604.4 NM_028757.2_1 - 1.2e-15 57.0 0.1 1.9e-15 56.3 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_028757.2_1 - 4.9e-12 45.1 0.0 8.9e-12 44.3 0.0 1.4 1 0 0 1 1 1 1 SH3 domain LIM PF00412.20 NM_028757.2_1 - 2.2e-11 43.6 10.7 2.2e-11 43.6 10.7 2.1 2 0 0 2 2 2 1 LIM domain SH3_2 PF07653.15 NM_028757.2_1 - 8.4e-05 22.1 0.0 0.00016 21.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ferritin PF00210.22 NM_010239.2_3 - 4.4e-38 130.3 2.8 5.5e-38 130.0 2.8 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.15 NM_010239.2_3 - 0.011 16.0 0.1 0.017 15.4 0.1 1.3 1 0 0 1 1 1 0 Rubrerythrin Zip PF02535.20 NM_028064.2_2 - 1.5e-63 214.9 12.7 1e-62 212.1 7.9 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter T-box PF00907.20 NM_011535.3_1 - 2.5e-81 272.2 0.2 4.6e-81 271.3 0.2 1.4 1 0 0 1 1 1 1 T-box TBX PF12598.6 NM_011535.3_1 - 7.5e-16 58.6 6.5 3.5e-15 56.4 6.5 2.3 1 0 0 1 1 1 1 T-box transcription factor CAF1 PF04857.18 NM_001034866.1_3 - 1.1e-78 264.5 0.0 1.3e-78 264.2 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease Prenyltransf PF01255.17 NM_030250.2_1 - 1.7e-08 34.1 0.0 1.1e-06 28.2 0.0 2.1 1 1 1 2 2 2 2 Putative undecaprenyl diphosphate synthase Y_phosphatase PF00102.25 NM_001163565.1_2 - 9.2e-74 247.8 0.4 1.5e-73 247.1 0.4 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 NM_001163565.1_2 - 0.0012 18.5 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_001163565.1_2 - 0.022 14.6 0.0 0.041 13.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family TAS2R PF05296.11 NM_053212.1_1 - 1.9e-87 293.1 40.2 2.4e-87 292.8 40.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) CD225 PF04505.10 NM_053212.1_1 - 0.35 10.9 0.1 0.35 10.9 0.1 3.0 3 1 0 3 3 3 0 Interferon-induced transmembrane protein F-box-like PF12937.5 NM_001286529.1_2 - 0.00039 20.1 1.8 0.0011 18.7 1.8 1.8 1 0 0 1 1 1 1 F-box-like MORN PF02493.18 NM_153384.3_2 - 0.3 10.9 1.6 0.92 9.4 1.6 1.9 1 0 0 1 1 1 0 MORN repeat DUF809 PF05663.9 NM_153384.3_2 - 1.6 8.7 7.3 3.2 7.8 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF809) 7tm_4 PF13853.4 NM_146789.1_1 - 1.6e-43 149.3 21.7 2e-43 149.0 21.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146789.1_1 - 6.9e-19 68.0 24.0 2.4e-18 66.2 24.0 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_146789.1_1 - 0.012 15.0 0.2 0.052 13.0 0.2 2.1 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus bZIP_1 PF00170.19 NM_016767.2_3 - 3.8e-12 46.0 8.2 6.2e-12 45.3 8.2 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_016767.2_3 - 3.4e-10 39.7 11.9 4.7e-10 39.3 11.9 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_016767.2_3 - 1.6e-06 28.4 8.5 2.6e-06 27.7 8.5 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor PKK PF12474.6 NM_016767.2_3 - 0.0029 17.5 6.0 0.0045 16.9 6.0 1.2 1 0 0 1 1 1 1 Polo kinase kinase Sec34 PF04136.13 NM_016767.2_3 - 0.025 14.3 0.9 0.036 13.8 0.9 1.1 1 0 0 1 1 1 0 Sec34-like family Phlebovirus_NSM PF07246.9 NM_016767.2_3 - 0.025 13.8 0.8 0.034 13.4 0.8 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M HALZ PF02183.16 NM_016767.2_3 - 0.048 13.7 5.0 0.079 13.1 5.0 1.3 1 0 0 1 1 1 0 Homeobox associated leucine zipper APG6 PF04111.10 NM_016767.2_3 - 0.076 12.3 2.3 0.1 11.9 2.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_11 PF13086.4 NM_016767.2_3 - 0.11 12.0 3.5 0.15 11.6 3.5 1.1 1 0 0 1 1 1 0 AAA domain TMCO5 PF14992.4 NM_016767.2_3 - 0.13 11.7 4.4 0.17 11.3 4.4 1.1 1 0 0 1 1 1 0 TMCO5 family IncA PF04156.12 NM_016767.2_3 - 0.15 11.7 2.6 0.2 11.3 2.6 1.1 1 0 0 1 1 1 0 IncA protein CtIP_N PF10482.7 NM_016767.2_3 - 0.23 11.4 6.1 0.43 10.5 6.1 1.3 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain DivIC PF04977.13 NM_016767.2_3 - 2 8.1 6.5 4 7.2 6.5 1.5 1 1 0 1 1 1 0 Septum formation initiator TNFR_c6 PF00020.16 NM_011610.3_1 - 4.8e-17 61.9 52.9 8.7e-07 29.1 9.4 6.0 5 0 0 5 5 5 4 TNFR/NGFR cysteine-rich region ACC_epsilon PF13822.4 NM_011610.3_2 - 5.4 7.6 8.6 0.69 10.5 1.7 2.8 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit TNFR_c6 PF00020.16 NM_010736.3_3 - 5e-19 68.3 38.4 7.2e-08 32.6 5.7 4.5 4 0 0 4 4 4 3 TNFR/NGFR cysteine-rich region Tubulin PF00091.23 NM_001313723.1_1 - 2.3e-33 115.9 0.0 2.9e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_001313723.1_3 - 3.6e-51 172.5 0.0 5.9e-51 171.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.23 NM_001313723.1_3 - 5.4e-07 29.9 0.0 8.1e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Cystatin PF00031.19 NM_027024.3_1 - 2.7e-16 59.5 0.3 3.7e-16 59.1 0.3 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 NM_027024.3_1 - 0.0051 17.0 0.2 0.0082 16.4 0.2 1.2 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cathelicidins PF00666.15 NM_027024.3_1 - 0.031 14.5 0.1 0.043 14.0 0.1 1.2 1 0 0 1 1 1 0 Cathelicidin Metallophos PF00149.26 NM_172707.3_3 - 3.5e-38 132.0 0.1 4.7e-38 131.6 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 NM_172707.3_3 - 1e-19 70.5 0.5 1.9e-19 69.7 0.5 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Amidohydro_1 PF01979.18 NM_022722.3_1 - 2.8e-37 128.7 0.1 3.6e-37 128.4 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 NM_022722.3_1 - 1.2e-15 57.8 1.7 7.8e-08 32.1 0.0 3.2 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_2 PF04909.12 NM_022722.3_1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Amidohydrolase 7tm_4 PF13853.4 NM_146489.1_1 - 3.5e-58 197.4 23.0 4e-58 197.2 23.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146489.1_1 - 3.7e-21 75.4 29.0 1.5e-20 73.4 29.0 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3915 PF13054.4 NM_011537.3_2 - 7.1 6.5 35.2 1.4 8.8 9.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3915) T-box PF00907.20 NM_011537.3_3 - 7.1e-81 270.7 0.0 1.1e-80 270.1 0.0 1.3 1 0 0 1 1 1 1 T-box LRR_8 PF13855.4 NM_021355.3_2 - 1.5e-32 111.0 26.7 2.5e-12 46.2 5.3 5.6 3 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 NM_021355.3_2 - 2.1e-20 72.3 25.8 2.5e-05 24.4 0.4 6.5 4 2 2 6 6 6 6 Leucine Rich repeats (2 copies) LRRNT PF01462.16 NM_021355.3_2 - 3.4e-08 32.8 2.5 3.4e-08 32.8 2.5 2.9 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 NM_021355.3_2 - 5.2e-07 29.2 3.1 0.018 14.4 0.4 3.7 1 1 3 4 4 4 2 Leucine-rich repeat LRR_6 PF13516.4 NM_021355.3_2 - 8.4e-05 22.2 26.8 1.1 9.4 0.3 8.8 8 0 0 8 8 8 3 Leucine Rich repeat LRR_1 PF00560.31 NM_021355.3_2 - 0.00023 21.0 26.3 1.1 9.9 0.2 9.4 6 2 3 9 9 9 2 Leucine Rich Repeat BTB_2 PF02214.20 NM_183285.3_1 - 3.9e-22 78.3 0.0 6.3e-22 77.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.29 NM_183285.3_1 - 0.036 14.1 0.0 0.056 13.5 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain BTB_3 PF16017.3 NM_183285.3_1 - 0.13 12.2 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain FAM180 PF15173.4 NM_173375.1_3 - 5.9e-56 188.1 0.2 8.1e-56 187.6 0.2 1.2 1 0 0 1 1 1 1 FAM180 family AKAP2_C PF15304.4 NM_009649.3_1 - 1.1e-06 28.1 0.2 2.5e-06 26.9 0.2 1.6 1 0 0 1 1 1 1 A-kinase anchor protein 2 C-terminus XK-related PF09815.7 NM_173393.2_1 - 1.1e-122 409.0 21.7 1.3e-122 408.7 21.7 1.1 1 0 0 1 1 1 1 XK-related protein ECF_trnsprt PF12822.5 NM_173393.2_1 - 0.67 9.9 9.5 1.4 8.8 9.5 1.5 1 0 0 1 1 1 0 ECF transporter, substrate-specific component NHR2 PF08788.9 NM_009823.1_3 - 3.9e-37 125.7 9.6 7.1e-37 124.9 9.6 1.4 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 NM_009823.1_3 - 2.4e-34 117.1 2.2 4.7e-34 116.2 2.2 1.5 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.16 NM_009823.1_3 - 1.2e-06 28.3 15.7 1.2e-06 28.3 15.7 2.5 2 0 0 2 2 2 1 MYND finger BBS1 PF14779.4 NM_009823.1_3 - 0.023 14.0 0.6 0.038 13.3 0.6 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 Ribosomal_L17 PF01196.17 NM_025301.2_2 - 4.2e-24 85.1 0.0 7e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 DUF667 PF05018.11 NM_008187.2_2 - 2.8e-95 317.2 0.9 3.5e-95 316.9 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Cathelicidins PF00666.15 NM_008694.2_1 - 5.1e-31 106.9 1.3 7.6e-31 106.3 1.3 1.2 1 0 0 1 1 1 1 Cathelicidin Cystatin PF00031.19 NM_008694.2_1 - 3.7e-07 30.2 0.1 1.2e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 Cystatin domain Spp-24 PF07448.9 NM_008694.2_1 - 0.0075 16.3 0.4 0.0075 16.3 0.4 1.7 2 0 0 2 2 2 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain DNA_repr_REX1B PF14966.4 NM_025577.2_1 - 5.4e-26 91.0 1.7 8.9e-26 90.3 1.7 1.3 1 0 0 1 1 1 1 DNA repair REX1-B FliJ PF02050.14 NM_025577.2_1 - 0.0014 18.7 4.4 0.56 10.3 0.5 2.4 2 1 0 2 2 2 2 Flagellar FliJ protein Cbl_N3 PF02762.12 NM_023224.5_1 - 1.4e-41 140.1 0.0 2.4e-41 139.3 0.0 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N PF02262.14 NM_023224.5_1 - 2.5e-41 140.5 0.0 4.1e-41 139.8 0.0 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N2 PF02761.12 NM_023224.5_1 - 1.5e-32 112.0 0.0 2.5e-32 111.3 0.0 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Prok-RING_4 PF14447.4 NM_023224.5_1 - 1.5e-11 43.8 12.4 3.9e-11 42.5 12.4 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 NM_023224.5_1 - 1e-09 38.0 12.4 3e-09 36.5 12.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_023224.5_1 - 1.1e-06 28.3 10.9 2.9e-06 26.9 10.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_023224.5_1 - 3.1e-06 27.2 12.0 3.1e-06 27.2 12.0 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_023224.5_1 - 0.00016 21.3 11.5 0.00041 20.0 11.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_023224.5_1 - 0.021 14.7 13.1 0.064 13.1 13.1 1.9 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_023224.5_1 - 0.14 12.0 13.2 0.22 11.5 10.6 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_4 PF14570.4 NM_023224.5_1 - 1.3 8.7 13.2 3.2 7.4 13.0 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.4 NM_023224.5_1 - 1.9 8.6 11.1 5.3 7.1 11.1 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING HemX PF04375.12 NM_024201.3_1 - 0.011 14.9 4.8 0.015 14.5 4.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Exonuc_VII_L PF02601.13 NM_024201.3_1 - 3.2 7.1 9.1 4.7 6.5 9.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Gtr1_RagA PF04670.10 NM_001004154.2_2 - 4.6e-105 350.0 1.6 6.5e-105 349.5 1.6 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.11 NM_001004154.2_2 - 3.9e-06 27.0 0.6 0.0015 18.6 0.5 2.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_001004154.2_2 - 5.2e-06 26.0 0.8 0.00029 20.3 0.8 2.3 1 1 0 1 1 1 1 Ras family Arf PF00025.19 NM_001004154.2_2 - 2.3e-05 23.8 1.2 9e-05 21.9 0.1 2.2 1 1 1 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001004154.2_2 - 0.0013 18.7 0.0 0.0041 17.1 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.25 NM_001004154.2_2 - 0.095 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter PduV-EutP PF10662.7 NM_001004154.2_2 - 0.11 12.2 0.1 0.24 11.0 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Mit_proteolip PF08039.9 NM_001004154.2_3 - 2.9 8.1 7.2 7.4 6.8 7.2 1.7 1 0 0 1 1 1 0 Mitochondrial proteolipid Defensin_propep PF00879.16 NM_001079933.2_1 - 2.3e-21 75.7 0.3 3.2e-21 75.3 0.3 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 NM_001079933.2_1 - 5.8e-09 36.2 17.4 7.9e-09 35.8 17.4 1.2 1 0 0 1 1 1 1 Mammalian defensin MF_alpha_N PF05436.9 NM_001079933.2_1 - 0.011 15.4 0.1 0.015 15.1 0.1 1.2 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus DUF3316 PF11777.6 NM_001079933.2_1 - 0.11 12.4 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3316) DUF1640 PF07798.9 NM_001162918.1_1 - 1.2e-38 132.8 14.2 3.1e-27 95.6 7.7 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1640) LIM PF00412.20 NM_001109043.1_1 - 0.013 15.6 16.0 0.026 14.6 16.0 1.5 1 0 0 1 1 1 0 LIM domain Endonuclease_7 PF02945.13 NM_001109043.1_1 - 0.11 12.4 7.6 0.24 11.2 7.6 1.5 1 0 0 1 1 1 0 Recombination endonuclease VII Keratin_B2_2 PF13885.4 NM_001126320.2_1 - 7.6e-31 105.7 279.4 4.5e-13 48.8 69.7 5.6 1 1 4 5 5 5 4 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_001126320.2_1 - 4.9e-08 33.0 134.5 4e-05 23.5 70.7 3.9 1 1 3 4 4 4 3 Keratin, high sulfur B2 protein Homeobox PF00046.27 NM_175730.5_3 - 1.1e-20 73.1 9.6 1.8e-20 72.4 9.6 1.4 1 0 0 1 1 1 1 Homeobox domain Somatostatin PF03002.13 NM_175730.5_3 - 0.12 12.2 2.4 0.39 10.6 2.4 1.8 1 0 0 1 1 1 0 Somatostatin/Cortistatin family FAM222A PF15258.4 NM_145430.2_1 - 8e-256 850.1 31.0 9.7e-256 849.8 31.0 1.1 1 0 0 1 1 1 1 Protein family of FAM222A DUF2981 PF11200.6 NM_145430.2_1 - 1.1 8.3 5.8 0.79 8.7 3.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2981) TMEM215 PF15746.3 NM_001166009.1_2 - 2.7e-112 373.6 0.0 3.6e-112 373.2 0.0 1.1 1 0 0 1 1 1 1 TMEM215 family zf-C2H2 PF00096.24 NM_009578.3_1 - 1.3e-11 44.1 40.3 3.7e-05 23.8 0.4 6.2 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_009578.3_1 - 4.7e-11 42.5 34.0 9.9e-06 25.6 3.9 6.3 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_009578.3_1 - 0.00082 19.9 0.4 0.00082 19.9 0.4 7.2 7 0 0 7 7 7 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_009578.3_1 - 0.02 14.5 0.2 0.02 14.5 0.2 3.8 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 NM_009578.3_1 - 0.022 14.4 0.1 0.022 14.4 0.1 5.2 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2HE PF16278.3 NM_009578.3_1 - 5.2 7.5 16.4 0.56 10.6 0.1 4.1 3 1 1 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger Filament PF00038.19 NM_001033314.3_1 - 0.017 14.6 3.6 0.034 13.6 3.6 1.4 1 0 0 1 1 1 0 Intermediate filament protein DRMBL PF07522.12 NM_001033314.3_1 - 0.12 12.5 1.5 0.23 11.6 0.2 2.0 2 0 0 2 2 2 0 DNA repair metallo-beta-lactamase Spc24 PF08286.9 NM_001033314.3_1 - 0.7 10.0 3.3 18 5.5 0.1 2.7 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Golgin_A5 PF09787.7 NM_001033314.3_1 - 1.2 8.4 7.6 0.16 11.2 2.4 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 TACI-CRD2 PF09305.8 NM_021349.1_1 - 1.3e-21 76.2 23.1 9.2e-21 73.5 9.8 2.9 3 0 0 3 3 3 2 TACI, cysteine-rich domain BCMA-Tall_bind PF09257.8 NM_021349.1_1 - 3.7e-07 30.0 20.4 0.0011 18.9 5.5 2.8 2 0 0 2 2 2 2 BCMA, TALL-1 binding Mago-bind PF09282.8 NM_021349.1_2 - 0.11 12.3 1.5 0.11 12.3 0.2 1.7 2 0 0 2 2 2 0 Mago binding SOAR PF16533.3 NM_009287.4_1 - 5.4e-43 144.9 2.3 5.4e-43 144.9 2.3 3.1 2 1 0 2 2 2 1 STIM1 Orai1-activating region SAM_2 PF07647.15 NM_009287.4_1 - 4.7e-07 29.7 0.4 1.2e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_009287.4_1 - 0.00043 20.5 0.1 0.001 19.3 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) AAA_11 PF13086.4 NM_009287.4_1 - 0.054 13.1 3.6 0.096 12.3 3.6 1.5 1 0 0 1 1 1 0 AAA domain Ste50p-SAM PF09235.8 NM_009287.4_1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Prominin PF05478.9 NM_009287.4_1 - 0.24 9.2 7.5 0.39 8.5 7.5 1.2 1 0 0 1 1 1 0 Prominin DUF4446 PF14584.4 NM_009287.4_1 - 1.7 8.5 5.7 0.36 10.7 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) APG6 PF04111.10 NM_009287.4_1 - 2.9 7.1 21.4 4.5 6.4 21.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_23 PF13476.4 NM_009287.4_1 - 4.2 7.7 19.2 15 5.9 14.1 3.1 2 1 0 2 2 2 0 AAA domain TMPIT PF07851.11 NM_009287.4_1 - 5.3 6.1 11.1 9.3 5.2 11.1 1.4 1 0 0 1 1 1 0 TMPIT-like protein adh_short PF00106.23 NM_175372.4_3 - 5.4e-35 120.5 0.1 2.3e-34 118.4 0.1 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_175372.4_3 - 5.5e-24 84.9 0.0 1.6e-23 83.4 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_175372.4_3 - 9.5e-05 22.2 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 NM_175372.4_3 - 0.00012 21.5 0.0 0.00017 21.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.16 NM_175372.4_3 - 0.0098 16.0 0.2 0.016 15.4 0.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Ca_hom_mod PF14798.4 NM_001081271.1_1 - 1.1e-91 306.3 4.4 1.4e-91 306.0 4.4 1.1 1 0 0 1 1 1 1 Calcium homeostasis modulator Nucleotid_trans PF03407.14 NM_001081271.1_1 - 0.13 12.1 0.0 1.7 8.4 0.0 2.1 2 0 0 2 2 2 0 Nucleotide-diphospho-sugar transferase Spindle_Spc25 PF08234.10 NM_025565.4_3 - 1.6e-20 72.9 0.2 3.1e-20 72.0 0.2 1.5 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Spc7 PF08317.9 NM_025565.4_3 - 0.00028 19.7 13.0 0.00039 19.2 13.0 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Viral_P18 PF04521.11 NM_025565.4_3 - 0.031 13.9 1.1 0.11 12.1 0.4 1.9 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein ALIX_LYPXL_bnd PF13949.4 NM_025565.4_3 - 0.11 11.6 9.6 0.17 11.0 9.6 1.1 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV MADF_DNA_bdg PF10545.7 NM_025565.4_3 - 0.13 12.4 2.8 0.27 11.5 2.8 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Atg14 PF10186.7 NM_025565.4_3 - 0.19 10.7 12.8 0.26 10.2 12.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF848 PF05852.9 NM_025565.4_3 - 1.9 8.4 8.3 3.2 7.7 8.3 1.3 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) GvpL_GvpF PF06386.9 NM_025565.4_3 - 2.2 8.0 4.7 3.2 7.5 4.7 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF573 PF04504.12 NM_025565.4_3 - 2.7 8.6 6.6 5.8 7.5 4.9 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF573 IncA PF04156.12 NM_025565.4_3 - 3.4 7.3 12.3 5.3 6.6 12.3 1.2 1 0 0 1 1 1 0 IncA protein PH_13 PF16652.3 NM_011365.4_3 - 2.4e-72 241.8 0.9 2.4e-72 241.8 0.9 3.7 3 2 1 4 4 3 1 Pleckstrin homology domain SH3_9 PF14604.4 NM_011365.4_3 - 1.4e-63 210.4 4.0 1.6e-15 56.6 0.0 5.5 5 0 0 5 5 5 5 Variant SH3 domain SH3_1 PF00018.26 NM_011365.4_3 - 6.6e-61 201.6 9.3 6e-14 51.2 0.1 5.5 5 0 0 5 5 5 5 SH3 domain SH3_2 PF07653.15 NM_011365.4_3 - 4.1e-57 189.6 0.9 1.6e-13 50.0 0.1 5.4 5 0 0 5 5 5 5 Variant SH3 domain RhoGEF PF00621.18 NM_011365.4_3 - 1.7e-42 145.6 0.6 1.7e-42 145.6 0.6 2.7 2 0 0 2 2 1 1 RhoGEF domain EF-hand_4 PF12763.5 NM_011365.4_3 - 6.4e-29 99.8 0.0 3.2e-13 49.4 0.0 3.0 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand C2 PF00168.28 NM_011365.4_3 - 2e-22 79.3 0.0 5.5e-22 77.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_1 PF00036.30 NM_011365.4_3 - 6.3e-09 34.6 0.1 0.0039 16.5 0.1 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_011365.4_3 - 6.2e-07 28.7 0.4 0.87 9.6 0.0 4.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 NM_011365.4_3 - 2.3e-06 27.9 0.0 0.006 16.9 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain pair PH PF00169.27 NM_011365.4_3 - 0.0068 16.8 0.0 0.026 14.9 0.0 2.1 1 0 0 1 1 1 1 PH domain EF-hand_8 PF13833.4 NM_011365.4_3 - 0.063 12.9 0.0 2.9 7.6 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.4 NM_011365.4_3 - 0.074 12.5 0.8 15 5.2 0.1 2.7 2 0 0 2 2 2 0 EF hand LRIF1 PF15741.3 NM_028081.2_3 - 3.7e-72 243.9 18.2 4.7e-72 243.5 18.2 1.0 1 0 0 1 1 1 1 Ligand-dependent nuclear receptor-interacting factor 1 DUF4342 PF14242.4 NM_028081.2_3 - 0.038 13.8 0.7 0.092 12.6 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) PKcGMP_CC PF16808.3 NM_028081.2_3 - 0.18 11.5 6.6 0.43 10.3 6.6 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase CAP_N PF01213.17 NM_001301067.1_3 - 6.7e-112 373.9 0.0 1.1e-111 373.2 0.0 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.9 NM_001301067.1_3 - 4.6e-64 214.6 4.6 6.7e-64 214.1 4.6 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.10 NM_001301067.1_3 - 0.0071 15.9 2.6 0.012 15.2 2.6 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C WH2 PF02205.18 NM_001301067.1_3 - 0.02 14.6 2.7 0.098 12.4 0.0 2.5 2 0 0 2 2 2 0 WH2 motif SMN PF06003.10 NM_001301067.1_3 - 0.26 10.4 3.6 0.47 9.5 3.6 1.4 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) bZIP_1 PF00170.19 NM_001307935.1_1 - 8.5e-12 44.9 15.2 1.6e-11 44.0 13.3 2.2 1 1 1 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.13 NM_001307935.1_1 - 4.4e-07 29.7 13.2 4.4e-07 29.7 13.2 2.3 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001307935.1_1 - 3e-06 27.5 10.3 5.3e-06 26.7 10.3 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.10 NM_001307935.1_1 - 4.3e-05 23.7 4.9 0.00014 22.1 4.9 1.8 1 0 0 1 1 1 1 Cell division protein ZapB DUF737 PF05300.9 NM_001307935.1_1 - 0.0014 18.9 0.1 0.002 18.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF737) EMP24_GP25L PF01105.22 NM_001307935.1_1 - 0.0043 16.9 1.5 0.0072 16.2 1.5 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ATG16 PF08614.9 NM_001307935.1_1 - 0.011 15.8 8.2 0.021 14.9 8.2 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) CASP_C PF08172.10 NM_001307935.1_1 - 0.013 14.7 3.4 0.022 14.0 3.4 1.3 1 0 0 1 1 1 0 CASP C terminal KASH_CCD PF14662.4 NM_001307935.1_1 - 0.016 14.9 10.5 0.016 14.9 10.5 1.6 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH SOGA PF11365.6 NM_001307935.1_1 - 0.028 15.4 5.2 0.069 14.1 5.2 1.6 1 0 0 1 1 1 0 Protein SOGA DUF4407 PF14362.4 NM_001307935.1_1 - 0.037 13.3 1.7 0.053 12.7 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2207 PF09972.7 NM_001307935.1_1 - 0.15 10.6 0.0 0.19 10.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Spc7 PF08317.9 NM_001307935.1_1 - 0.49 9.1 8.7 0.7 8.6 8.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HAUS6_N PF14661.4 NM_001307935.1_1 - 1.5 8.3 7.5 2.2 7.7 7.5 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF724 PF05266.12 NM_001307935.1_1 - 1.6 8.4 6.8 2.7 7.7 6.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Atg14 PF10186.7 NM_001307935.1_1 - 5.6 5.8 12.7 8.8 5.2 12.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ADIP PF11559.6 NM_001307935.1_1 - 9.6 6.1 15.2 17 5.3 15.2 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding SspP PF08179.10 NM_001307935.1_3 - 1.4 9.3 3.7 18 5.7 0.7 2.5 2 0 0 2 2 2 0 Small acid-soluble spore protein P family Claudin_2 PF13903.4 NM_001081198.1_3 - 3.7e-61 206.1 8.8 4.7e-61 205.8 8.8 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 NM_001081198.1_3 - 0.0047 16.7 9.7 0.11 12.2 4.5 2.4 2 0 0 2 2 2 2 PMP-22/EMP/MP20/Claudin family 7tm_1 PF00001.19 NM_175668.4_2 - 2e-37 128.7 10.0 3.3e-37 128.0 10.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_175668.4_2 - 1.3e-05 25.0 2.5 1.3e-05 25.0 2.5 1.8 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srv PF10323.7 NM_175668.4_2 - 0.0014 17.9 3.2 0.0023 17.2 3.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 NM_175668.4_2 - 0.0017 17.6 4.0 0.0025 17.0 4.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx PgaD PF13994.4 NM_175668.4_2 - 0.044 13.6 1.7 0.86 9.4 1.2 2.5 2 0 0 2 2 2 0 PgaD-like protein Gal-bind_lectin PF00337.20 NM_001291057.1_1 - 1.1e-66 222.3 0.3 6.4e-33 113.0 0.0 2.2 2 0 0 2 2 2 2 Galactoside-binding lectin Plexin_cytopl PF08337.10 NM_008883.2_1 - 5.4e-251 834.0 1.0 6.5e-251 833.7 1.0 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.17 NM_008883.2_1 - 5e-72 242.9 0.0 6.8e-72 242.4 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 NM_008883.2_1 - 9e-40 134.5 12.2 2.5e-10 40.1 0.1 5.9 6 0 0 6 6 6 4 IPT/TIG domain PSI PF01437.23 NM_008883.2_1 - 3.9e-18 65.6 58.1 2.6e-08 34.2 13.1 3.7 3 0 0 3 3 3 3 Plexin repeat 7tm_4 PF13853.4 NM_146895.1_1 - 6.6e-46 157.2 22.7 8.5e-46 156.8 22.7 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146895.1_1 - 4.3e-21 75.2 27.9 1.2e-20 73.8 27.9 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146895.1_1 - 4.2e-05 22.9 25.5 0.00023 20.5 25.5 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SLC3A2_N PF16028.3 NM_146895.1_1 - 0.051 13.0 4.6 1.2 8.6 0.2 2.6 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus PTS_EIIB PF00367.18 NM_146895.1_1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 phosphotransferase system, EIIB Pro_isomerase PF00160.19 NM_177356.3_1 - 6.2e-06 26.4 0.0 9.1e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.26 NM_177356.3_1 - 0.0044 16.6 0.0 0.013 15.2 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat Lamp PF01299.15 NM_177356.3_3 - 1.7e-71 241.3 9.3 1.7e-71 241.3 9.3 1.6 1 1 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) Pro_isomerase PF00160.19 NM_177356.3_3 - 5.1e-23 82.0 0.1 8.4e-23 81.2 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ATP-synt_S1 PF05827.10 NM_177356.3_3 - 0.00031 20.4 1.5 0.00059 19.5 1.5 1.3 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) TPR_1 PF00515.26 NM_177356.3_3 - 0.00093 18.8 0.3 0.023 14.4 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 NM_177356.3_3 - 0.092 12.8 0.1 0.47 10.6 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4519 PF15012.4 NM_177356.3_3 - 5.5 7.1 6.1 13 5.9 4.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) GCM PF03615.13 NM_008104.2_2 - 1.5e-69 232.2 1.9 2.3e-69 231.6 1.9 1.3 1 0 0 1 1 1 1 GCM motif protein SCAMP PF04144.11 NM_020270.3_3 - 4.2e-68 229.0 17.6 7.3e-68 228.2 17.6 1.4 1 0 0 1 1 1 1 SCAMP family Tubulin PF00091.23 NM_009446.2_1 - 1.6e-67 227.4 0.0 2.2e-67 227.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_009446.2_1 - 2.3e-51 173.1 0.0 3.7e-51 172.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 NM_009446.2_1 - 0.0016 18.0 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Kinesin PF00225.21 NM_001145832.1_1 - 9.3e-107 356.7 0.1 1.8e-106 355.7 0.0 1.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 NM_001145832.1_1 - 2.9e-45 153.8 0.1 1.1e-44 151.9 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding Spc7 PF08317.9 NM_001145832.1_1 - 0.00051 18.9 18.5 0.00051 18.9 18.5 3.3 1 1 2 3 3 3 1 Spc7 kinetochore protein Reo_sigmaC PF04582.10 NM_001145832.1_1 - 0.61 9.3 8.3 0.47 9.7 0.4 3.0 1 1 2 3 3 3 0 Reovirus sigma C capsid protein DUF4407 PF14362.4 NM_001145832.1_1 - 1.1 8.4 23.3 0.15 11.3 7.1 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) AAA_22 PF13401.4 NM_001145832.1_1 - 1.5 9.0 5.2 6 7.0 0.0 3.1 2 1 0 2 2 2 0 AAA domain Golgin_A5 PF09787.7 NM_001145832.1_1 - 9.4 5.5 51.3 1.6 8.0 28.0 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 Fez1 PF06818.13 NM_001145832.1_1 - 9.8 6.4 48.9 4.4 7.6 17.4 3.4 1 1 0 2 2 2 0 Fez1 Pkinase PF00069.23 NM_009097.5_1 - 1.2e-149 496.8 0.0 9.2e-77 257.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_009097.5_1 - 2.8e-77 259.4 0.0 2.6e-41 141.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 NM_009097.5_1 - 1.3e-14 54.1 0.0 3.3e-07 29.8 0.0 3.3 3 1 1 4 4 4 2 Kinase-like Kdo PF06293.12 NM_009097.5_1 - 2.8e-10 39.8 0.0 8e-06 25.2 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.22 NM_009097.5_1 - 2.9e-07 31.0 1.6 8.8e-07 29.4 1.6 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.21 NM_009097.5_1 - 0.00011 22.1 0.0 0.41 10.4 0.0 2.8 2 1 0 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.4 NM_009097.5_1 - 0.00082 18.9 0.0 4.7 6.7 0.0 3.3 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.7 NM_009097.5_1 - 0.0028 17.0 0.0 0.37 10.2 0.0 2.6 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL p47_phox_C PF08944.9 NM_009097.5_3 - 2 7.7 5.9 5.7 6.3 5.9 1.8 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain Gasdermin PF04598.10 NM_026960.4_1 - 1.2e-171 571.6 0.4 1.4e-171 571.4 0.4 1.0 1 0 0 1 1 1 1 Gasdermin family EKR PF10371.7 NM_026960.4_1 - 0.13 12.0 0.0 0.41 10.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function GBP PF02263.17 NM_194336.2_3 - 8.7e-115 382.3 0.0 8.7e-115 382.3 0.0 2.3 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 NM_194336.2_3 - 2.4e-114 381.6 28.2 3.2e-114 381.2 28.2 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain RHD3 PF05879.10 NM_194336.2_3 - 0.022 12.8 0.0 0.022 12.8 0.0 2.8 2 1 2 4 4 4 0 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.21 NM_194336.2_3 - 0.13 12.3 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF1943 PF09172.9 NM_194336.2_3 - 2.2 7.4 12.1 4.1 6.5 12.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) PMP22_Claudin PF00822.18 NM_001193619.1_2 - 8.1e-53 178.6 10.4 1e-52 178.3 10.4 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001193619.1_2 - 2.1e-12 47.1 9.6 4.8e-11 42.6 9.6 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.9 NM_001193619.1_2 - 0.031 14.0 4.2 0.046 13.4 4.2 1.3 1 0 0 1 1 1 0 Amastin surface glycoprotein DUF4064 PF13273.4 NM_001193619.1_2 - 0.15 12.3 5.4 3.8 7.8 5.6 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) SUR7 PF06687.10 NM_001193619.1_2 - 0.19 11.2 3.3 0.15 11.5 1.7 1.6 1 1 0 1 1 1 0 SUR7/PalI family Clc-like PF07062.10 NM_001193619.1_2 - 0.28 10.5 0.1 0.28 10.5 0.1 2.0 2 1 0 2 2 2 0 Clc-like WD40 PF00400.30 NM_026789.4_1 - 4.1e-14 52.6 5.9 0.0099 16.6 0.0 8.8 9 0 0 9 9 9 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_026789.4_1 - 7e-05 22.9 0.1 1 9.6 0.1 5.4 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain ATG16 PF08614.9 NM_026789.4_1 - 0.0011 19.1 27.2 0.0011 19.1 27.2 4.5 2 1 2 4 4 4 2 Autophagy protein 16 (ATG16) PQQ_2 PF13360.4 NM_026789.4_1 - 0.005 16.3 0.1 1 8.8 0.0 2.5 2 0 0 2 2 2 2 PQQ-like domain DUF972 PF06156.11 NM_026789.4_1 - 0.0083 16.6 8.1 0.0083 16.6 8.1 7.2 3 2 4 7 7 7 1 Protein of unknown function (DUF972) Reo_sigmaC PF04582.10 NM_026789.4_1 - 0.056 12.7 3.3 0.089 12.0 0.3 2.5 2 1 2 4 4 4 0 Reovirus sigma C capsid protein PQQ_3 PF13570.4 NM_026789.4_1 - 0.26 11.7 2.1 20 5.7 0.0 4.3 5 1 1 6 6 6 0 PQQ-like domain Turandot PF07240.9 NM_026789.4_1 - 0.43 10.5 8.8 0.46 10.3 1.1 3.3 2 1 0 2 2 2 0 Stress-inducible humoral factor Turandot FUSC PF04632.10 NM_026789.4_1 - 1.4 7.3 6.3 0.15 10.5 0.3 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family Lectin_C PF00059.19 NM_001037800.3_2 - 9.9e-21 74.4 5.8 1.9e-20 73.5 5.8 1.5 1 0 0 1 1 1 1 Lectin C-type domain DUF1719 PF08224.9 NM_001037800.3_2 - 0.43 9.5 4.5 1.5 7.8 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1719) IncA PF04156.12 NM_001037800.3_2 - 0.68 9.6 9.7 1.5 8.4 9.7 1.5 1 0 0 1 1 1 0 IncA protein Galactosyl_T PF01762.19 NM_198611.2_1 - 4.2e-41 140.8 0.0 5.1e-41 140.5 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 NM_198611.2_1 - 1.4e-08 34.3 0.0 2.2e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Fringe-like DUF604 PF04646.10 NM_198611.2_1 - 0.016 14.5 0.0 0.024 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF604 tRNA-synt_1g PF09334.9 NM_001003913.2_2 - 4.1e-146 486.6 0.0 5.3e-146 486.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) WHEP-TRS PF00458.18 NM_001003913.2_2 - 3e-16 59.2 7.4 3e-16 59.2 7.4 1.7 2 0 0 2 2 2 1 WHEP-TRS domain tRNA-synt_1 PF00133.20 NM_001003913.2_2 - 4.1e-07 28.5 0.2 0.0047 15.1 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) GST_C PF00043.23 NM_001003913.2_2 - 6.2e-05 23.0 0.0 0.00014 21.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 NM_001003913.2_2 - 0.00025 20.8 0.0 0.0012 18.7 0.0 2.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Anticodon_1 PF08264.11 NM_001003913.2_2 - 0.00084 19.2 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA GST_C_3 PF14497.4 NM_001003913.2_2 - 0.045 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 NM_001003913.2_2 - 0.068 13.4 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DUF16 PF01519.14 NM_001003913.2_2 - 0.18 12.1 0.7 0.42 11.0 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 Laminin_EGF PF00053.22 NM_001003913.2_2 - 7.9 6.6 8.5 20 5.3 8.1 1.9 1 1 0 1 1 1 0 Laminin EGF domain LINES_N PF14694.4 NM_152815.2_1 - 1.3e-145 485.2 6.5 1.3e-145 485.2 6.5 1.8 2 0 0 2 2 2 1 Lines N-terminus LINES_C PF14695.4 NM_152815.2_1 - 1.1e-17 63.1 0.1 2.5e-17 61.9 0.1 1.7 1 0 0 1 1 1 1 Lines C-terminus Chromosome_seg PF13889.4 NM_172691.3_1 - 1.4e-17 63.4 0.2 2.5e-17 62.6 0.2 1.4 1 0 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.4 NM_172691.3_1 - 1.4e-13 51.1 0.0 2.7e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) IGFBP PF00219.16 NM_023612.3_2 - 2.2e-07 31.3 21.9 2.2e-07 31.3 21.9 4.6 5 0 0 5 5 5 1 Insulin-like growth factor binding protein Pkinase PF00069.23 NM_001166655.1_3 - 4.5e-74 249.0 0.0 6e-74 248.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001166655.1_3 - 7.4e-38 130.2 0.0 3e-37 128.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001166655.1_3 - 8.8e-07 28.4 0.0 1.6e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.20 NM_001166655.1_3 - 0.00015 21.3 0.1 0.00025 20.6 0.1 1.2 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.4 NM_001166655.1_3 - 0.00026 20.5 0.4 0.13 11.7 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 NM_001166655.1_3 - 0.00046 19.5 0.4 0.00081 18.7 0.4 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MdcG PF10620.7 NM_001166655.1_3 - 0.0089 15.7 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl-dephospho-CoA transferase MdcG APH PF01636.21 NM_001166655.1_3 - 0.068 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family CCDC85 PF10226.7 NM_181577.5_3 - 3.1e-94 314.0 11.6 4.7e-94 313.4 10.5 1.8 2 0 0 2 2 2 1 CCDC85 family AMH_N PF04709.10 NM_181577.5_3 - 0.034 13.0 0.2 0.059 12.2 0.2 1.3 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region TSC22 PF01166.16 NM_181577.5_3 - 1.4 9.2 8.3 10 6.4 0.0 3.3 3 0 0 3 3 3 0 TSC-22/dip/bun family bZIP_1 PF00170.19 NM_181577.5_3 - 5.3 7.1 11.6 1.4 9.0 0.1 3.2 3 0 0 3 3 3 0 bZIP transcription factor Kinesin PF00225.21 NM_001166407.1_3 - 3.9e-105 351.3 0.1 3.9e-105 351.3 0.1 1.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 NM_001166407.1_3 - 3.9e-15 56.0 0.0 3.5e-13 49.6 0.0 2.8 2 0 0 2 2 2 1 Microtubule binding DUF2383 PF09537.8 NM_001166407.1_3 - 0.055 13.7 5.9 0.25 11.6 2.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) Bcl-2 PF00452.17 NM_153516.2_1 - 3e-10 40.4 0.0 5.1e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family C2 PF00168.28 NM_001136117.1_1 - 7e-07 29.4 0.0 1.4e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.4 NM_001136117.1_1 - 0.16 11.3 0.1 0.26 10.7 0.1 1.2 1 0 0 1 1 1 0 CEP76 C2 domain Leu_zip PF15294.4 NM_033322.2_3 - 9.2e-122 405.7 33.8 1.1e-121 405.4 33.8 1.1 1 0 0 1 1 1 1 Leucine zipper SesA PF17107.3 NM_033322.2_3 - 0.95 9.5 9.2 0.13 12.3 3.8 2.2 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_1 PF00515.26 NM_001163638.1_1 - 8.8e-19 66.3 20.1 0.00062 19.3 0.0 8.2 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001163638.1_1 - 4.4e-17 60.7 17.3 0.00016 21.5 0.0 7.9 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001163638.1_1 - 2.7e-16 58.1 21.6 0.018 15.0 0.0 7.8 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001163638.1_1 - 2.8e-12 46.2 6.6 0.0051 17.4 0.4 7.2 2 2 5 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001163638.1_1 - 1.6e-08 34.6 19.6 0.0091 16.1 0.2 5.7 2 1 4 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001163638.1_1 - 5.5e-08 33.2 4.4 0.32 11.6 0.0 5.7 4 2 1 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001163638.1_1 - 5.3e-07 29.6 21.0 0.0003 20.8 1.2 4.4 2 1 1 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.4 NM_001163638.1_1 - 8.6e-07 28.4 0.2 2.1 8.0 0.1 5.4 5 0 0 5 5 5 1 TPR repeat TPR_19 PF14559.4 NM_001163638.1_1 - 3.5e-06 27.3 10.7 0.69 10.3 0.0 5.2 2 2 4 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001163638.1_1 - 3.4e-05 23.8 12.3 0.94 9.9 0.0 6.0 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_15 PF13429.4 NM_001163638.1_1 - 0.0014 17.8 0.2 0.0054 15.8 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001163638.1_1 - 0.013 15.5 0.8 38 4.4 0.0 4.3 3 2 1 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.10 NM_001163638.1_1 - 0.029 14.9 1.2 15 6.3 0.0 3.4 3 1 0 3 3 2 0 Sel1 repeat TPR_21 PF09976.7 NM_001163638.1_1 - 0.11 12.1 0.3 2.7 7.6 0.1 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain TPR_7 PF13176.4 NM_001163638.1_1 - 0.28 11.2 15.0 2 8.5 0.0 6.1 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001163638.1_1 - 0.46 11.1 6.0 26 5.6 0.0 4.7 6 0 0 6 6 5 0 Tetratricopeptide repeat Ras PF00071.20 NM_133717.3_2 - 1e-34 119.4 0.0 1.6e-34 118.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_133717.3_2 - 6e-17 61.9 0.0 1.1e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_133717.3_2 - 0.00022 20.6 0.0 0.00033 20.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family 7tm_4 PF13853.4 NM_146702.1_1 - 3.1e-53 181.2 17.2 3.9e-53 180.9 17.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146702.1_1 - 3.7e-22 78.7 18.8 6.8e-22 77.8 18.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1772 PF08592.9 NM_146702.1_1 - 2 8.6 10.9 0.047 13.9 1.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Halogen_Hydrol PF10112.7 NM_146702.1_1 - 3.3 7.5 8.4 0.11 12.4 2.1 1.8 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein PMP22_Claudin PF00822.18 NM_001194923.1_2 - 6.7e-28 97.5 15.5 8.9e-27 93.8 15.5 2.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001194923.1_2 - 3.4e-07 30.1 16.4 3.4e-07 30.1 16.4 2.7 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.4 NM_001194923.1_2 - 0.00037 20.7 1.5 0.00037 20.7 1.5 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF4064) HgmA PF04209.11 NM_013547.3_2 - 9.7e-223 739.3 0.0 1.1e-222 739.1 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase TOH_N PF12549.6 NM_013547.3_3 - 0.063 13.0 0.9 0.19 11.5 0.9 1.9 1 0 0 1 1 1 0 Tyrosine hydroxylase N terminal DUF1899 PF08953.9 NM_139128.1_1 - 1.1e-30 105.1 0.0 2.4e-30 104.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 NM_139128.1_1 - 3.9e-22 77.7 0.2 1e-21 76.4 0.2 1.8 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 NM_139128.1_1 - 1.6e-17 63.4 6.9 5e-05 23.9 0.3 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_139128.1_1 - 1.4e-09 38.0 0.2 0.0013 18.9 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Trimer_CC PF08954.9 NM_139128.1_1 - 0.0061 16.0 1.9 0.67 9.4 1.9 2.4 2 0 0 2 2 2 1 Trimerisation motif Coatomer_WDAD PF04053.12 NM_139128.1_1 - 0.049 12.6 0.0 0.063 12.2 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region PALB2_WD40 PF16756.3 NM_139128.1_1 - 0.079 11.7 0.1 0.21 10.3 0.0 1.6 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain DUF4140 PF13600.4 NM_139128.1_1 - 0.14 12.5 0.5 0.28 11.5 0.5 1.4 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Pkinase PF00069.23 NM_001276315.1_2 - 3.7e-75 252.6 0.0 5e-75 252.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001276315.1_2 - 4.1e-37 127.7 0.1 2.3e-36 125.3 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.20 NM_001276315.1_2 - 0.00077 19.0 0.1 0.0015 18.0 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.4 NM_001276315.1_2 - 0.024 13.8 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.12 NM_001276315.1_2 - 0.08 12.2 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Prion PF00377.16 NM_011170.3_2 - 2.2e-33 114.4 2.6 3.1e-33 114.0 2.6 1.2 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 NM_011170.3_2 - 2.2e-16 59.2 2.0 4.5e-16 58.2 2.0 1.5 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal Gly-zipper_Omp PF13488.4 NM_011170.3_2 - 0.017 15.0 5.7 0.035 14.0 5.7 1.5 1 0 0 1 1 1 0 Glycine zipper Aldedh PF00171.20 NM_153543.2_1 - 5.3e-172 572.3 0.0 6.6e-172 572.0 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Formyl_trans_N PF00551.17 NM_153543.2_1 - 2.2e-44 151.3 0.0 3.9e-44 150.4 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.16 NM_153543.2_1 - 3.4e-15 55.9 0.0 6.8e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain PP-binding PF00550.23 NM_153543.2_1 - 9.2e-05 22.6 0.0 0.00016 21.8 0.0 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF1487 PF07368.9 NM_153543.2_1 - 0.0077 15.6 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) 7tm_4 PF13853.4 NM_146852.2_1 - 7.8e-53 179.9 15.1 9.5e-53 179.6 15.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146852.2_1 - 3.2e-21 75.6 21.6 8.8e-21 74.2 21.6 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146852.2_1 - 3.6e-06 26.4 19.1 3.6e-06 26.4 19.1 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx Abhydrolase_1 PF00561.18 NM_021460.3_3 - 1.3e-28 100.2 0.5 1.6e-28 99.9 0.5 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.14 NM_021460.3_3 - 1.5e-24 85.2 0.0 3.3e-24 84.1 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.6 NM_021460.3_3 - 9.8e-05 21.6 0.0 0.0018 17.5 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.5 NM_021460.3_3 - 0.1 13.1 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF900 PF05990.10 NM_021460.3_3 - 0.21 11.0 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Forkhead PF00250.16 NM_183298.1_1 - 1.3e-36 124.6 0.0 1.8e-36 124.2 0.0 1.2 1 0 0 1 1 1 1 Forkhead domain 7tm_4 PF13853.4 NM_001011771.2_1 - 5.3e-46 157.5 28.5 6.2e-46 157.2 28.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011771.2_1 - 1.1e-19 70.6 30.3 2e-19 69.8 30.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011771.2_1 - 0.19 10.9 31.1 0.41 9.8 31.1 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx COG4 PF08318.10 NM_133973.2_1 - 9.4e-95 317.4 4.1 2.2e-94 316.2 4.1 1.7 1 0 0 1 1 1 1 COG4 transport protein RINT1_TIP1 PF04437.11 NM_133973.2_1 - 6.2e-07 28.5 0.9 1.6e-06 27.2 0.9 1.6 1 0 0 1 1 1 1 RINT-1 / TIP-1 family Vps53_N PF04100.10 NM_133973.2_1 - 0.013 14.3 8.0 0.025 13.4 3.8 3.1 3 0 0 3 3 3 0 Vps53-like, N-terminal Spc24 PF08286.9 NM_133973.2_1 - 0.29 11.3 1.6 0.95 9.6 0.4 2.6 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Dynamin_N PF00350.21 NM_001039160.2_1 - 0.00035 20.5 0.0 0.00035 20.5 0.0 3.4 4 0 0 4 4 4 1 Dynamin family MMR_HSR1 PF01926.21 NM_001039160.2_1 - 0.0021 18.0 0.1 0.014 15.4 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Arrestin_N PF00339.27 NM_001271360.1_2 - 6.5e-43 146.2 0.0 2.2e-39 134.7 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 NM_001271360.1_2 - 5.4e-27 94.7 0.1 8.6e-27 94.0 0.1 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain DUF912 PF06024.10 NM_026293.3_3 - 0.012 15.8 0.6 0.081 13.1 0.1 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) COX2_TM PF02790.13 NM_026293.3_3 - 0.038 14.0 0.3 0.069 13.2 0.3 1.4 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain DUF4834 PF16118.3 NM_026293.3_3 - 0.044 14.6 0.8 1.3 9.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF1510 PF07423.9 NM_026293.3_3 - 2.7 7.2 9.1 1.2 8.4 1.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1510) PGAP1 PF07819.11 NM_177311.4_3 - 0.034 13.7 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Hydrolase_4 PF12146.6 NM_177311.4_3 - 0.087 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 zf-C3HC4_2 PF13923.4 NM_001304270.1_1 - 1.9e-10 40.2 6.0 1.2e-09 37.8 6.0 2.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001304270.1_1 - 1.1e-09 38.2 6.0 1.1e-09 38.2 6.0 3.3 4 0 0 4 4 1 1 Ring finger domain zf-RING_UBOX PF13445.4 NM_001304270.1_1 - 3.2e-09 36.5 3.7 3.2e-09 36.5 3.7 2.2 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_001304270.1_1 - 1e-08 34.8 6.6 1e-08 34.8 6.6 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001304270.1_1 - 1.6e-08 34.2 6.7 1.6e-08 34.2 6.7 2.9 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 NM_001304270.1_1 - 3.4e-08 33.1 7.1 3.4e-08 33.1 7.1 3.0 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_001304270.1_1 - 4.8e-06 26.2 11.4 0.00022 20.9 11.6 3.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 NM_001304270.1_1 - 6.5e-05 22.4 5.2 0.00036 20.1 5.2 2.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.5 NM_001304270.1_1 - 6.8e-05 22.9 6.2 0.00041 20.5 6.2 2.4 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.4 NM_001304270.1_1 - 0.0032 17.5 7.1 0.0032 17.5 7.1 3.2 3 1 0 3 3 1 1 zinc finger of C3HC4-type, RING Rtf2 PF04641.10 NM_001304270.1_1 - 0.0036 16.6 0.2 0.006 15.9 0.2 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-UDP PF14569.4 NM_001304270.1_1 - 0.047 13.7 9.1 0.018 15.0 3.3 2.8 3 0 0 3 3 3 0 Zinc-binding RING-finger TerY_C PF15616.4 NM_001304270.1_1 - 0.21 11.6 6.3 0.41 10.6 1.8 2.4 2 0 0 2 2 2 0 TerY-C metal binding domain UPF0139 PF03669.11 NM_001304270.1_1 - 1.8 8.3 5.2 0.16 11.7 0.5 1.6 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0139) zf-RING_10 PF16685.3 NM_001304270.1_1 - 9.9 6.3 14.0 0.3 11.1 5.5 2.5 2 0 0 2 2 2 0 zinc RING finger of MSL2 RnaseA PF00074.18 NM_021472.4_3 - 1.7e-39 135.0 7.2 2.5e-39 134.4 7.2 1.3 1 0 0 1 1 1 1 Pancreatic ribonuclease PAS_3 PF08447.10 NM_016868.3_3 - 5e-21 74.7 0.0 4.2e-15 55.6 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 NM_016868.3_3 - 2.3e-18 66.2 0.0 5.4e-15 55.4 0.0 2.4 2 0 0 2 2 2 2 PAS domain HIF-1 PF11413.6 NM_016868.3_3 - 2.7e-14 52.1 5.9 5.4e-14 51.2 5.9 1.5 1 0 0 1 1 1 1 Hypoxia-inducible factor-1 PAS PF00989.23 NM_016868.3_3 - 5.7e-14 51.9 0.0 4.6e-06 26.5 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.8 NM_016868.3_3 - 5.9e-07 29.6 0.0 0.025 14.7 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.5 NM_016868.3_3 - 8.6e-06 25.8 0.0 0.11 12.7 0.0 2.3 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 NM_016868.3_3 - 0.049 13.5 0.3 0.088 12.6 0.3 1.4 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain NDK PF00334.17 NM_001077529.2_2 - 4e-56 188.6 0.0 4.9e-56 188.3 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Trypsin PF00089.24 NM_178372.2_2 - 2.1e-60 204.1 0.1 2.5e-60 203.9 0.1 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_178372.2_2 - 0.0001 22.5 0.1 0.00024 21.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_178372.2_2 - 0.00036 21.3 0.1 0.00066 20.4 0.1 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain Plectin PF00681.18 NM_201391.2_2 - 1.8e-297 959.0 37.1 5e-21 74.2 0.0 29.8 26 5 6 32 32 32 26 Plectin repeat CH PF00307.29 NM_201391.2_2 - 2.4e-47 159.5 0.2 1.7e-22 79.6 0.2 3.3 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_201391.2_2 - 3e-05 23.6 0.1 0.016 14.9 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain Imm70 PF15601.4 NM_201391.2_2 - 0.73 9.2 3.7 0.9 9.0 0.0 3.2 3 0 0 3 3 3 0 Immunity protein 70 Spore_YhaL PF14147.4 NM_201391.2_2 - 7.2 6.3 8.2 70 3.1 8.2 2.9 1 0 0 1 1 1 0 Sporulation protein YhaL Myosin_head PF00063.19 NM_001164573.1_1 - 5.4e-236 784.9 0.0 7e-236 784.5 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 NM_001164573.1_1 - 5.1e-29 101.1 0.3 5.1e-29 101.1 0.3 1.6 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding Zeta_toxin PF06414.10 NM_001164573.1_1 - 0.032 13.4 0.0 0.057 12.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin IQ PF00612.25 NM_001164573.1_1 - 0.11 12.2 13.1 0.12 12.1 0.2 4.1 4 0 0 4 4 4 0 IQ calmodulin-binding motif TsaE PF02367.15 NM_001164573.1_1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sushi PF00084.18 NM_001025575.2_1 - 3.7e-28 97.8 36.6 1.2e-09 38.5 1.5 5.3 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) ITI_HC_C PF06668.10 NM_001306078.1_3 - 2e-65 219.9 0.0 3.4e-65 219.1 0.0 1.4 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.8 NM_001306078.1_3 - 1.1e-26 93.1 0.5 2.2e-26 92.2 0.5 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.26 NM_001306078.1_3 - 1.8e-20 73.8 0.0 2.8e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 NM_001306078.1_3 - 8.6e-17 61.3 0.0 1.5e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 NM_001306078.1_3 - 5.3e-10 39.8 0.0 1.2e-09 38.6 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 NM_001306078.1_3 - 0.0016 17.8 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Sars6 PF12133.6 NM_027453.2_2 - 0.16 11.8 0.4 0.29 11.0 0.4 1.3 1 0 0 1 1 1 0 Open reading frame 6 from SARS coronavirus NAC PF01849.16 NM_027453.2_3 - 1.6e-24 85.5 0.1 2.9e-24 84.7 0.1 1.4 1 0 0 1 1 1 1 NAC domain Vps16_N PF04841.11 NM_030559.3_1 - 2.9e-163 543.3 0.0 3.7e-163 542.9 0.0 1.1 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.10 NM_030559.3_1 - 8.7e-147 488.2 0.8 1.2e-146 487.7 0.8 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region 7tm_4 PF13853.4 NM_146491.1_1 - 2.7e-49 168.3 17.7 3.4e-49 167.9 17.7 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146491.1_1 - 5.6e-19 68.3 23.6 9e-19 67.6 23.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146491.1_1 - 0.00018 20.9 23.3 0.0003 20.1 23.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Plectin PF00681.18 NM_201393.2_2 - 1.5e-297 959.1 37.1 5e-21 74.2 0.0 29.8 26 5 6 32 32 32 26 Plectin repeat CH PF00307.29 NM_201393.2_2 - 2.3e-47 159.5 0.2 1.7e-22 79.6 0.2 3.3 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_201393.2_2 - 3e-05 23.6 0.1 0.016 14.9 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain Imm70 PF15601.4 NM_201393.2_2 - 0.72 9.3 3.7 0.89 9.0 0.0 3.2 3 0 0 3 3 3 0 Immunity protein 70 Spore_YhaL PF14147.4 NM_201393.2_2 - 7.1 6.3 8.2 70 3.1 8.2 2.9 1 0 0 1 1 1 0 Sporulation protein YhaL zf-C2H2 PF00096.24 NM_020497.2_3 - 7.9e-10 38.5 49.1 0.00039 20.6 1.9 8.0 8 0 0 8 8 8 5 Zinc finger, C2H2 type zf-AD PF07776.13 NM_020497.2_3 - 1.2e-09 38.1 0.5 1.2e-09 38.1 0.5 3.7 4 0 0 4 4 4 1 Zinc-finger associated domain (zf-AD) zf-C2H2_4 PF13894.4 NM_020497.2_3 - 4.7e-07 30.0 56.5 0.013 16.1 0.7 9.0 9 0 0 9 9 9 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_020497.2_3 - 0.00019 21.6 42.4 0.0091 16.3 0.7 7.0 8 0 0 8 8 8 4 Zinc-finger double domain CpXC PF14353.4 NM_020497.2_3 - 0.0029 17.5 8.3 0.17 11.8 0.2 3.6 1 1 2 3 3 3 1 CpXC protein Zn-ribbon_8 PF09723.8 NM_020497.2_3 - 0.024 14.6 14.2 0.88 9.6 3.5 4.5 4 0 0 4 4 4 0 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_020497.2_3 - 0.19 11.6 11.8 0.14 12.1 0.2 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger INO80_Ies4 PF08193.9 NM_020497.2_3 - 1.9 8.3 14.2 0.031 14.1 6.8 1.7 2 0 0 2 2 2 0 INO80 complex subunit Ies4 DUF2197 PF09963.7 NM_020497.2_3 - 3.6 7.8 5.7 1.6 8.9 0.3 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2197) ig PF00047.23 NM_145426.2_2 - 9e-07 28.9 0.1 2.2e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_145426.2_2 - 4.2e-06 27.1 0.0 9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_145426.2_2 - 6.1e-06 26.1 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.15 NM_145426.2_2 - 0.0081 16.2 0.5 1.4 8.9 0.5 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 NM_145426.2_2 - 0.009 16.2 0.0 0.025 14.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Lectin_C PF00059.19 NM_001288664.1_1 - 1.9e-11 44.5 6.6 3.6e-11 43.6 2.6 2.5 3 0 0 3 3 3 1 Lectin C-type domain Pkinase_Tyr PF07714.15 NM_001110204.1_2 - 3.2e-35 121.6 0.0 4.6e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001110204.1_2 - 3.6e-35 121.5 0.0 5.4e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 NM_001110204.1_2 - 1.7e-16 59.3 0.3 1.7e-16 59.3 0.3 1.8 2 0 0 2 2 2 1 Transforming growth factor beta type I GS-motif APH PF01636.21 NM_001110204.1_2 - 0.052 13.3 0.1 0.19 11.5 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.4 NM_001110204.1_2 - 0.061 12.8 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Filament PF00038.19 NM_009751.2_3 - 2e-13 50.5 38.1 1.6e-10 40.9 14.4 2.2 1 1 1 2 2 2 2 Intermediate filament protein Spc7 PF08317.9 NM_009751.2_3 - 0.0028 16.5 14.3 0.0028 16.5 14.3 2.4 1 1 1 2 2 2 1 Spc7 kinetochore protein DUF1664 PF07889.10 NM_009751.2_3 - 0.28 11.1 5.9 0.16 11.8 2.6 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 NM_009751.2_3 - 0.49 10.3 8.9 0.027 14.4 1.4 2.6 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus NAD_binding_1 PF00175.19 NM_009751.2_3 - 0.58 10.7 5.8 0.42 11.1 1.3 2.7 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain AAA_13 PF13166.4 NM_009751.2_3 - 1.6 7.1 18.2 2.8 6.4 18.2 1.3 1 0 0 1 1 1 0 AAA domain DUF5082 PF16888.3 NM_009751.2_3 - 1.8 8.8 12.6 0.77 10.0 8.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) DIT1_PvcA PF05141.10 NM_009751.2_3 - 2 7.7 5.7 2.5 7.4 5.0 1.5 1 1 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein LemA PF04011.10 NM_009751.2_3 - 2.4 7.5 11.8 0.093 12.1 3.1 2.4 1 1 1 2 2 2 0 LemA family NPV_P10 PF05531.10 NM_009751.2_3 - 9.6 6.6 7.9 2.5 8.5 0.2 3.6 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.4 NM_009751.2_3 - 9.6 5.3 23.1 0.044 13.0 5.7 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) MOEP19 PF16005.3 NM_001113187.1_1 - 9.9e-23 79.9 0.0 1.7e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 KH-like RNA-binding domain CD36 PF01130.19 NM_001159556.1_3 - 2.6e-148 494.3 0.5 3.3e-148 493.9 0.5 1.1 1 0 0 1 1 1 1 CD36 family N_BRCA1_IG PF16158.3 NM_001252222.1_3 - 1.6e-30 105.7 0.4 3.5e-30 104.6 0.4 1.6 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.22 NM_001252222.1_3 - 8.1e-13 47.9 0.0 1.5e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 PB1 domain ZZ PF00569.15 NM_001252222.1_3 - 5.2e-05 22.8 6.9 0.00012 21.6 6.9 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.14 NM_001252222.1_3 - 0.096 12.9 5.3 0.24 11.6 5.3 1.7 1 0 0 1 1 1 0 C1 domain SIR2 PF02146.15 NM_001122766.1_2 - 9.6e-58 194.9 0.0 1.2e-57 194.5 0.0 1.1 1 0 0 1 1 1 1 Sir2 family YdjO PF14169.4 NM_001122766.1_2 - 0.0018 17.9 1.7 0.0036 16.9 1.7 1.4 1 0 0 1 1 1 1 Cold-inducible protein YdjO PUF PF00806.17 NM_001159603.1_1 - 1.6e-67 219.4 13.3 9.3e-09 34.4 0.1 8.9 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat CPL PF08144.9 NM_001159603.1_1 - 0.15 12.2 0.7 15 5.8 0.0 3.4 1 1 2 3 3 3 0 CPL (NUC119) domain 7tm_3 PF00003.20 NM_177764.4_1 - 3.7e-57 193.7 29.9 8.3e-57 192.5 29.9 1.6 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_177764.4_1 - 6.4e-41 140.5 0.1 9.5e-41 139.9 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_177764.4_1 - 3.1e-20 71.7 12.9 6.3e-20 70.8 12.9 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 NM_177764.4_1 - 0.29 10.8 4.1 0.91 9.2 4.1 1.8 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 NM_001081405.1_1 - 6.6e-61 206.0 27.0 1.6e-60 204.7 27.0 1.7 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001081405.1_1 - 1.1e-31 110.1 1.0 1.5e-31 109.6 1.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001081405.1_1 - 1.5e-17 63.1 12.3 5.3e-17 61.4 12.3 2.0 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 NM_001081405.1_1 - 0.25 11.0 6.3 0.93 9.2 6.3 1.9 1 0 0 1 1 1 0 Putative ephrin-receptor like Alpha_kinase PF02816.16 NM_001267711.1_3 - 9.5e-54 182.3 0.0 1.5e-53 181.6 0.0 1.3 1 0 0 1 1 1 1 Alpha-kinase family Sel1 PF08238.10 NM_001267711.1_3 - 9.5e-07 29.2 5.0 0.19 12.3 0.0 5.2 5 0 0 5 5 5 3 Sel1 repeat Myosin_head PF00063.19 NM_008659.3_2 - 1.7e-245 816.3 0.0 2.1e-245 815.9 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 NM_008659.3_2 - 1.8e-31 109.1 0.0 3.3e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 NM_008659.3_2 - 1.8e-07 30.2 17.7 0.00071 19.0 1.7 3.8 3 0 0 3 3 3 2 IQ calmodulin-binding motif AAA_16 PF13191.4 NM_008659.3_2 - 0.039 14.2 0.0 0.097 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 NM_008659.3_2 - 0.05 13.7 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain ECH_1 PF00378.18 NM_001254754.1_1 - 3e-50 170.7 0.3 3.7e-50 170.5 0.3 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 NM_001254754.1_1 - 4e-28 98.8 0.3 1.6e-27 96.8 0.2 1.7 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase IF4E PF01652.16 NM_001039683.2_1 - 5.9e-09 35.8 0.2 8.7e-09 35.2 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E IF4E PF01652.16 NM_001039683.2_3 - 3.5e-31 108.0 1.0 5.5e-31 107.4 1.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Lectin_C PF00059.19 NM_001190320.1_3 - 4.7e-21 75.4 3.4 4.7e-21 75.4 3.4 1.9 1 1 1 2 2 2 1 Lectin C-type domain adh_short PF00106.23 NM_173047.3_2 - 4.4e-36 124.1 0.0 2.6e-27 95.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 NM_173047.3_2 - 2e-28 99.4 0.0 1.4e-19 70.5 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_173047.3_2 - 4.3e-08 33.1 0.0 8.1e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.16 NM_173047.3_2 - 0.11 12.6 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Cadherin PF00028.15 NM_001081377.2_1 - 3.2e-99 325.5 11.9 8.3e-20 70.9 0.2 7.4 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.9 NM_001081377.2_1 - 4.9e-82 275.0 0.5 8e-82 274.3 0.5 1.3 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.10 NM_001081377.2_1 - 1.5e-17 63.1 0.0 2.8e-08 33.3 0.0 5.7 6 0 0 6 6 6 3 Cadherin-like Cadherin_3 PF16184.3 NM_001081377.2_1 - 8.1e-07 28.9 17.2 0.86 9.5 0.0 5.9 6 0 0 6 6 6 4 Cadherin-like EphA2_TM PF14575.4 NM_001081377.2_1 - 0.01 16.5 0.3 0.027 15.1 0.3 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain He_PIG PF05345.10 NM_001081377.2_1 - 0.016 15.2 8.5 1.6 8.9 0.0 5.1 5 0 0 5 5 5 0 Putative Ig domain DUF1510 PF07423.9 NM_001081377.2_1 - 0.03 13.6 0.2 0.056 12.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) AP3D1 PF06375.9 NM_001081377.2_1 - 0.051 13.7 0.8 0.15 12.2 0.8 1.8 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 PDEase_I PF00233.17 NM_008806.2_2 - 1.1e-78 264.1 4.2 1.1e-78 264.1 4.2 2.1 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 NM_008806.2_2 - 4.1e-25 88.7 0.0 1.3e-12 48.3 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.4 NM_008806.2_2 - 2.3e-11 44.0 0.0 4.4e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.4 NM_008806.2_2 - 8.9e-09 35.6 0.0 0.0012 19.0 0.0 3.3 2 1 0 2 2 2 2 GAF domain OB_NTP_bind PF07717.14 NM_008806.2_2 - 0.011 15.8 0.1 0.11 12.5 0.1 2.3 1 1 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold NARG2_C PF10505.7 NM_145618.3_2 - 1e-82 276.7 0.2 1.6e-82 276.0 0.2 1.3 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus Peptidase_C14 PF00656.20 NM_009812.2_1 - 4.7e-52 177.3 2.5 5.2e-52 177.1 1.4 1.6 2 0 0 2 2 2 1 Caspase domain DED PF01335.19 NM_009812.2_1 - 7.3e-44 147.8 17.0 3.1e-23 81.7 2.5 2.4 2 0 0 2 2 2 2 Death effector domain PYRIN PF02758.14 NM_009812.2_1 - 0.83 9.8 5.0 0.33 11.1 0.8 2.3 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain Dynamin_N PF00350.21 NM_001199177.1_3 - 3.1e-37 128.1 0.1 3.1e-37 128.1 0.1 2.1 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.21 NM_001199177.1_3 - 0.00014 21.8 0.0 0.001 19.0 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 NM_001199177.1_3 - 0.0076 15.6 0.0 0.2 11.0 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF1593 PF07632.9 NM_001199177.1_3 - 0.0095 15.3 0.0 0.021 14.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) Roc PF08477.11 NM_001199177.1_3 - 0.077 13.1 0.0 1.3 9.2 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF2267 PF10025.7 NM_001199177.1_3 - 0.13 12.4 1.2 0.5 10.5 1.2 2.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) DUF3338 PF11819.6 NM_001199177.1_3 - 0.2 11.6 4.1 9.9 6.0 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3338) Ephrin_rec_like PF07699.11 NM_001199177.1_3 - 0.33 10.6 3.0 1.7 8.4 0.4 2.6 2 0 0 2 2 2 0 Putative ephrin-receptor like KxDL PF10241.7 NM_001199177.1_3 - 3.5 7.8 9.8 2.1 8.5 3.0 3.0 2 0 0 2 2 2 0 Uncharacterized conserved protein NPV_P10 PF05531.10 NM_001199177.1_3 - 8 6.9 8.6 0.64 10.4 0.5 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TBPIP PF07106.11 NM_008949.3_3 - 9.2e-66 220.6 6.5 1.2e-65 220.3 6.5 1.1 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Mnd1 PF03962.13 NM_008949.3_3 - 2.2e-11 43.9 9.3 2.7e-11 43.6 9.3 1.1 1 0 0 1 1 1 1 Mnd1 family Penicillinase_R PF03965.14 NM_008949.3_3 - 8e-05 22.8 0.1 0.00018 21.7 0.1 1.6 1 0 0 1 1 1 1 Penicillinase repressor Snapin_Pallidin PF14712.4 NM_008949.3_3 - 0.00019 21.7 1.3 0.00035 20.8 1.3 1.3 1 0 0 1 1 1 1 Snapin/Pallidin SlyX PF04102.10 NM_008949.3_3 - 0.00088 19.7 3.4 0.05 14.1 3.9 2.4 1 1 1 2 2 2 2 SlyX Spc24 PF08286.9 NM_008949.3_3 - 0.0022 18.1 4.5 0.55 10.4 4.5 2.4 1 1 0 1 1 1 1 Spc24 subunit of Ndc80 FUR PF01475.17 NM_008949.3_3 - 0.0023 17.9 0.0 0.0071 16.3 0.0 1.7 1 0 0 1 1 1 1 Ferric uptake regulator family HAP1_N PF04849.11 NM_008949.3_3 - 0.0023 17.0 4.2 0.0033 16.5 4.2 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region DivIC PF04977.13 NM_008949.3_3 - 0.0026 17.3 4.8 0.13 11.9 0.0 2.4 1 1 1 2 2 2 1 Septum formation initiator HAUS-augmin3 PF14932.4 NM_008949.3_3 - 0.01 15.2 7.1 0.014 14.8 7.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Ax_dynein_light PF10211.7 NM_008949.3_3 - 0.013 15.3 10.3 0.18 11.6 7.6 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain FlxA PF14282.4 NM_008949.3_3 - 0.014 15.2 5.1 0.11 12.4 1.2 2.5 1 1 1 2 2 2 0 FlxA-like protein HBM PF16591.3 NM_008949.3_3 - 0.015 14.6 1.7 0.027 13.8 1.7 1.4 1 0 0 1 1 1 0 Helical bimodular sensor domain Seryl_tRNA_N PF02403.20 NM_008949.3_3 - 0.016 15.3 2.5 0.016 15.3 2.5 2.1 2 1 0 2 2 1 0 Seryl-tRNA synthetase N-terminal domain CENP-F_leu_zip PF10473.7 NM_008949.3_3 - 0.018 15.0 5.0 0.035 14.0 5.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ZapB PF06005.10 NM_008949.3_3 - 0.026 14.8 6.8 0.033 14.5 4.1 2.2 1 1 1 2 2 2 0 Cell division protein ZapB Prefoldin_2 PF01920.18 NM_008949.3_3 - 0.027 14.3 7.3 1.5 8.7 2.2 2.5 1 1 1 2 2 2 0 Prefoldin subunit ATG16 PF08614.9 NM_008949.3_3 - 0.028 14.5 6.7 0.046 13.8 6.5 1.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.10 NM_008949.3_3 - 0.028 13.7 0.3 0.038 13.2 0.3 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein IncA PF04156.12 NM_008949.3_3 - 0.031 13.9 5.5 0.044 13.4 5.5 1.3 1 0 0 1 1 1 0 IncA protein Syntaxin_2 PF14523.4 NM_008949.3_3 - 0.039 14.2 1.1 0.086 13.1 1.1 1.5 1 0 0 1 1 1 0 Syntaxin-like protein SKA1 PF07160.10 NM_008949.3_3 - 0.048 13.4 4.2 0.073 12.8 4.2 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Fmp27_WPPW PF10359.7 NM_008949.3_3 - 0.057 12.1 5.8 0.072 11.8 5.8 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain CorA PF01544.16 NM_008949.3_3 - 0.065 12.4 0.5 0.092 11.9 0.5 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein GCR PF02155.13 NM_008949.3_3 - 0.083 11.8 0.4 0.11 11.4 0.4 1.1 1 0 0 1 1 1 0 Glucocorticoid receptor SesA PF17107.3 NM_008949.3_3 - 0.086 12.9 2.0 0.16 12.0 2.0 1.4 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Uds1 PF15456.4 NM_008949.3_3 - 0.092 12.8 5.2 3.1 7.8 1.2 2.3 2 0 0 2 2 2 0 Up-regulated During Septation Vps51 PF08700.9 NM_008949.3_3 - 0.094 12.7 1.5 11 6.1 1.5 2.4 1 1 0 1 1 1 0 Vps51/Vps67 TMF_TATA_bd PF12325.6 NM_008949.3_3 - 0.1 12.7 5.8 0.16 12.0 4.7 1.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding LPP PF04728.11 NM_008949.3_3 - 0.11 12.7 0.7 4.8 7.5 0.7 2.4 1 1 1 2 2 2 0 Lipoprotein leucine-zipper TMPIT PF07851.11 NM_008949.3_3 - 0.12 11.5 5.2 0.16 11.0 5.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein Syntaxin-6_N PF09177.9 NM_008949.3_3 - 0.12 12.8 2.6 0.22 12.0 2.6 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF1664 PF07889.10 NM_008949.3_3 - 0.12 12.2 0.8 0.23 11.3 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) TFIIE_beta PF02186.13 NM_008949.3_3 - 0.13 12.5 0.8 2.3 8.4 0.0 2.4 2 0 0 2 2 2 0 TFIIE beta subunit core domain GIT_CC PF16559.3 NM_008949.3_3 - 0.13 12.2 3.7 1.8 8.5 3.7 2.3 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Cnn_1N PF07989.9 NM_008949.3_3 - 0.13 12.3 5.8 5.2 7.1 1.9 2.5 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 ABC_tran_CTD PF16326.3 NM_008949.3_3 - 0.17 12.0 4.0 1.2 9.3 4.0 2.3 1 1 0 1 1 1 0 ABC transporter C-terminal domain CENP-H PF05837.10 NM_008949.3_3 - 0.22 11.8 3.9 0.53 10.6 3.9 1.7 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF972 PF06156.11 NM_008949.3_3 - 0.38 11.3 5.4 1.5 9.4 5.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF4363 PF14276.4 NM_008949.3_3 - 0.43 10.5 3.8 1.8 8.5 1.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4363) NPA PF16469.3 NM_008949.3_3 - 0.43 11.1 13.1 0.057 14.0 8.5 1.8 2 1 0 2 2 1 0 Nematode polyprotein allergen ABA-1 Swi5 PF07061.9 NM_008949.3_3 - 0.44 10.5 8.4 5.6 7.0 0.6 2.6 1 1 1 2 2 2 0 Swi5 SKA2 PF16740.3 NM_008949.3_3 - 0.44 10.2 6.2 0.9 9.2 4.6 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF342 PF03961.11 NM_008949.3_3 - 0.62 8.5 6.4 0.52 8.7 5.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF342) APG6 PF04111.10 NM_008949.3_3 - 0.8 8.9 11.3 2.1 7.5 11.2 1.6 1 1 0 1 1 1 0 Autophagy protein Apg6 TMF_DNA_bd PF12329.6 NM_008949.3_3 - 0.83 9.6 7.9 0.059 13.2 2.7 1.7 2 0 0 2 2 1 0 TATA element modulatory factor 1 DNA binding ADIP PF11559.6 NM_008949.3_3 - 0.9 9.5 11.4 10 6.0 10.8 2.5 1 1 1 2 2 1 0 Afadin- and alpha -actinin-Binding AAA_23 PF13476.4 NM_008949.3_3 - 2.4 8.5 7.2 0.63 10.4 3.6 1.7 1 1 1 2 2 2 0 AAA domain VGPC1_C PF16799.3 NM_008949.3_3 - 5.1 7.0 6.4 0.54 10.1 0.2 2.4 3 0 0 3 3 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 CCDC-167 PF15188.4 NM_008949.3_3 - 5.7 7.2 7.3 4.4 7.6 3.6 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 7tm_4 PF13853.4 NM_146859.2_1 - 2.7e-54 184.7 18.5 3.2e-54 184.4 18.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146859.2_1 - 7.6e-27 94.1 20.9 2.7e-26 92.3 20.9 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146859.2_1 - 1.5e-07 30.9 17.3 2.3e-07 30.3 17.3 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_146859.2_1 - 1.8e-05 24.0 18.6 9.4e-05 21.7 18.6 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx JmjC PF02373.20 NM_172382.2_1 - 1.4e-42 144.6 0.6 3.3e-42 143.4 0.1 1.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.4 NM_172382.2_1 - 5.1e-33 113.4 8.3 5.1e-33 113.4 8.3 2.7 2 1 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 NM_172382.2_1 - 2.3e-15 56.4 4.8 2.3e-15 56.4 4.8 3.8 2 1 2 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.4 NM_172382.2_1 - 1.5e-14 53.1 4.8 1.5e-14 53.1 4.8 3.1 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.15 NM_172382.2_1 - 2.3e-14 52.9 0.0 7.3e-14 51.3 0.0 2.0 1 0 0 1 1 1 1 jmjN domain PHD PF00628.27 NM_172382.2_1 - 3.4e-08 33.1 24.6 5.2e-07 29.3 1.4 4.3 4 0 0 4 4 4 2 PHD-finger Herpes_pp85 PF04637.10 NM_172382.2_1 - 0.18 10.0 0.1 0.29 9.4 0.1 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF3498 PF12004.6 NM_001114125.1_2 - 2.2e-194 647.4 9.6 3.7e-194 646.6 9.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3498) RasGAP PF00616.17 NM_001114125.1_2 - 1.1e-26 93.6 5.6 2e-14 53.7 0.0 3.0 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.28 NM_001114125.1_2 - 5.5e-08 32.9 0.0 9.3e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain Bacillus_HBL PF05791.9 NM_001114125.1_2 - 0.00027 20.6 5.0 0.00049 19.7 5.0 1.3 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) PH_2 PF08458.8 NM_001114125.1_2 - 0.022 15.0 0.0 0.048 13.9 0.0 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH PF00169.27 NM_001114125.1_2 - 0.03 14.7 0.4 0.082 13.3 0.0 2.0 2 0 0 2 2 2 0 PH domain EMP24_GP25L PF01105.22 NM_001114125.1_2 - 1.8 8.3 4.3 3.3 7.5 4.3 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Gly_acyl_tr_N PF06021.9 NM_001114125.1_2 - 2 8.4 4.9 3.5 7.5 4.9 1.3 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase XLF PF09302.9 NM_001114125.1_2 - 9.5 6.2 7.1 21 5.1 7.1 1.5 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component 7tm_4 PF13853.4 NM_207137.3_1 - 6.1e-45 154.0 13.1 7.5e-45 153.7 13.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207137.3_1 - 5.9e-19 68.2 14.9 5.9e-19 68.2 14.9 1.9 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) VIR_N PF15912.3 NM_001081183.1_2 - 4.7e-106 354.1 11.8 4.7e-106 354.1 11.8 1.7 2 0 0 2 2 2 1 Virilizer, N-terminal Mpp10 PF04006.10 NM_001081183.1_2 - 1.3 7.3 17.0 2.2 6.5 17.0 1.3 1 0 0 1 1 1 0 Mpp10 protein 7tm_4 PF13853.4 NM_146653.1_1 - 8.9e-61 205.9 17.6 1.1e-60 205.7 17.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146653.1_1 - 1.3e-29 103.2 23.7 1.3e-29 103.2 23.7 1.9 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146653.1_1 - 0.0006 19.1 14.9 0.0006 19.1 14.9 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx UPF0197 PF05251.10 NM_146653.1_1 - 0.047 13.6 0.1 0.047 13.6 0.1 2.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0197) SLC3A2_N PF16028.3 NM_146653.1_1 - 3.6 7.1 6.5 53 3.3 0.1 3.5 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus HH_signal PF01085.16 NM_007857.5_2 - 3.9e-82 273.6 0.0 5.2e-82 273.1 0.0 1.2 1 0 0 1 1 1 1 Hedgehog amino-terminal signalling domain Hint PF01079.18 NM_007857.5_2 - 2.8e-70 236.0 0.0 3.8e-70 235.6 0.0 1.2 1 0 0 1 1 1 1 Hint module Peptidase_M15_3 PF08291.9 NM_007857.5_2 - 0.00055 19.9 0.2 0.00098 19.1 0.2 1.3 1 0 0 1 1 1 1 Peptidase M15 Vint PF14623.4 NM_007857.5_2 - 0.0027 17.4 0.0 0.0056 16.4 0.0 1.5 2 0 0 2 2 2 1 Hint-domain Syncollin PF15138.4 NM_026716.3_2 - 1.8e-56 189.0 0.2 2.3e-56 188.7 0.2 1.1 1 0 0 1 1 1 1 Syncollin DDOST_48kD PF03345.12 NM_007838.2_1 - 1.5e-151 504.8 0.0 1.7e-151 504.6 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta ELM2 PF01448.22 NM_001286223.1_3 - 3e-09 37.4 2.9 4.5e-09 36.8 0.0 2.4 2 0 0 2 2 2 1 ELM2 domain Myb_DNA-binding PF00249.29 NM_001286223.1_3 - 1.6e-05 24.8 0.1 3.6e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 NM_001286223.1_3 - 0.018 14.7 0.6 0.037 13.8 0.0 1.7 2 0 0 2 2 2 0 Myb DNA-binding like Peptidase_C2 PF00648.19 NM_007601.3_2 - 3.9e-135 449.5 0.0 5.7e-135 448.9 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 NM_007601.3_2 - 3.3e-56 189.4 0.0 6.1e-56 188.5 0.0 1.5 1 0 0 1 1 1 1 Calpain large subunit, domain III Calpain_u2 PF16648.3 NM_007601.3_2 - 1.8e-28 98.6 8.5 3.3e-28 97.8 8.5 1.4 1 0 0 1 1 1 1 Unstructured region on Calpain-3 EF-hand_1 PF00036.30 NM_007601.3_2 - 9.4e-18 62.3 1.8 2e-05 23.7 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_007601.3_2 - 1.1e-14 52.9 2.5 0.0002 20.9 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 NM_007601.3_2 - 6e-11 41.8 6.4 1.7e-07 30.7 0.2 4.0 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.4 NM_007601.3_2 - 6.5e-09 36.0 7.6 0.0017 18.7 0.5 4.2 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 NM_007601.3_2 - 1.2e-08 34.0 2.2 0.13 11.7 2.6 3.9 4 0 0 4 4 4 3 EF hand PAP2_C PF14360.4 NM_001168525.1_1 - 3.6e-27 94.5 14.6 3.6e-27 94.5 14.6 2.8 3 1 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.19 NM_001168525.1_1 - 1.6e-06 27.8 6.9 1.6e-06 27.8 6.9 2.3 2 0 0 2 2 2 1 PAP2 superfamily SAM_1 PF00536.28 NM_001168525.1_1 - 0.0003 21.0 0.1 0.00071 19.8 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAP2_3 PF14378.4 NM_001168525.1_1 - 0.0046 16.5 15.4 0.018 14.6 15.4 1.9 1 1 0 1 1 1 1 PAP2 superfamily SAM_2 PF07647.15 NM_001168525.1_1 - 0.046 13.7 0.0 0.088 12.8 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 NM_001168525.1_1 - 0.047 13.5 0.0 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain O-FucT PF10250.7 NM_080463.3_2 - 6.6e-75 252.6 0.0 9.1e-75 252.1 0.0 1.2 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Pkinase_Tyr PF07714.15 NM_001283045.1_1 - 9.5e-99 329.7 0.0 1.3e-98 329.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001283045.1_1 - 3.4e-48 164.2 0.0 5.1e-48 163.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain F_actin_bind PF08919.8 NM_001283045.1_1 - 9.4e-28 96.4 0.2 1.6e-27 95.6 0.2 1.4 1 0 0 1 1 1 1 F-actin binding SH2 PF00017.22 NM_001283045.1_1 - 2.6e-23 81.8 0.2 5e-23 80.8 0.2 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 NM_001283045.1_1 - 2.8e-12 45.9 0.0 5.2e-12 45.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001283045.1_1 - 2.2e-08 33.7 0.0 4e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001283045.1_1 - 2.9e-07 29.9 0.0 5.6e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 NM_001283045.1_1 - 0.00011 22.3 0.2 0.00028 20.9 0.2 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain Pkinase PF00069.23 NM_011161.5_1 - 1e-62 211.8 0.0 1.3e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_011161.5_1 - 1.3e-28 99.9 0.0 1.7e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_011161.5_1 - 7.8e-07 28.5 0.0 1.2e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_011161.5_1 - 0.00075 19.3 0.5 0.026 14.3 0.0 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.20 NM_011161.5_1 - 0.032 13.7 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Cas_CT1975 PF09344.8 NM_011161.5_1 - 0.033 13.5 0.0 0.047 13.0 0.0 1.1 1 0 0 1 1 1 0 CT1975-like protein Kinase-like PF14531.4 NM_011161.5_1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like 2-Hacid_dh_C PF02826.17 NM_001198860.1_2 - 2.5e-55 186.4 0.0 3.5e-55 186.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 NM_001198860.1_2 - 3.1e-28 98.0 0.0 4.1e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 NM_001198860.1_2 - 9.9e-05 22.4 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Cellsynth_D PF03500.11 NM_001198860.1_2 - 0.17 11.7 0.0 0.46 10.2 0.0 1.7 1 0 0 1 1 1 0 Cellulose synthase subunit D RGS PF00615.17 NM_009063.4_3 - 7.9e-34 116.3 4.6 1.2e-33 115.7 4.6 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain Calsarcin PF05556.9 NM_133363.3_3 - 3.7e-32 111.6 0.0 6.3e-32 110.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) SH2 PF00017.22 NM_177816.3_1 - 4.6e-14 52.1 0.0 9.8e-14 51.0 0.0 1.6 1 0 0 1 1 1 1 SH2 domain CDC45 PF02724.12 NM_177816.3_1 - 9.1 4.3 14.4 13 3.8 14.4 1.3 1 0 0 1 1 1 0 CDC45-like protein S_100 PF01023.17 NM_011313.2_1 - 2.9e-17 62.0 0.5 4.8e-17 61.3 0.5 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 NM_011313.2_1 - 8.5e-07 29.2 0.4 1.3e-06 28.7 0.4 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_011313.2_1 - 0.00056 19.1 0.6 0.0042 16.4 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 NM_011313.2_1 - 0.029 14.2 0.2 7.3 6.7 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain WD40 PF00400.30 NM_028032.3_1 - 1.7e-06 28.5 4.4 10 7.0 0.1 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_028032.3_1 - 0.00052 20.1 0.1 1.1 9.5 0.0 3.5 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Chorion_S16 PF05836.10 NM_028032.3_2 - 1.2 9.2 7.3 1.9 8.6 7.3 1.2 1 0 0 1 1 1 0 Chorion protein S16 Ribosomal_S4e PF00900.18 NM_009094.2_2 - 2.1e-40 136.3 0.5 1.1e-39 134.1 0.5 2.0 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.3 NM_009094.2_2 - 1.3e-30 104.6 0.1 2.3e-30 103.8 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.10 NM_009094.2_2 - 3.9e-22 77.9 6.2 9.9e-22 76.6 6.2 1.8 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.23 NM_009094.2_2 - 6.5e-06 25.6 0.0 1.1e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 S4 domain KOW PF00467.27 NM_009094.2_2 - 9.7e-06 25.2 0.2 2.9e-05 23.7 0.2 1.9 1 0 0 1 1 1 1 KOW motif WND PF07861.9 NM_009094.2_2 - 0.14 11.4 0.8 0.24 10.7 0.8 1.3 1 0 0 1 1 1 0 WisP family N-Terminal Region DEAD PF00270.27 NM_134059.2_2 - 6.5e-44 149.6 0.0 2.9e-43 147.6 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_134059.2_2 - 8.1e-32 109.8 0.0 5.1e-30 104.0 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain zf-CCHC PF00098.21 NM_134059.2_2 - 0.0016 18.3 1.5 0.003 17.5 1.5 1.5 1 0 0 1 1 1 1 Zinc knuckle ResIII PF04851.13 NM_134059.2_2 - 0.031 14.2 0.0 0.078 12.8 0.0 1.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SecA_DEAD PF07517.12 NM_134059.2_2 - 0.082 12.1 0.0 0.23 10.6 0.0 1.7 2 0 0 2 2 2 0 SecA DEAD-like domain UTP25 PF06862.10 NM_134059.2_2 - 0.11 11.1 0.0 0.32 9.6 0.0 1.6 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 zf-CCHC_4 PF14392.4 NM_134059.2_2 - 0.15 11.6 1.3 0.32 10.6 1.3 1.6 1 0 0 1 1 1 0 Zinc knuckle ERCC3_RAD25_C PF16203.3 NM_134059.2_2 - 0.25 10.4 0.0 0.25 10.4 0.0 1.8 3 0 0 3 3 3 0 ERCC3/RAD25/XPB C-terminal helicase Erf4 PF10256.7 NM_009767.2_2 - 2e-08 34.2 0.0 4e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Tim54 PF11711.6 NM_009767.2_2 - 0.15 10.7 3.0 0.23 10.0 3.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SCHIP-1 PF10148.7 NM_009767.2_2 - 0.44 10.0 5.3 0.68 9.4 5.3 1.1 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 Myc_N PF01056.16 NM_009767.2_2 - 0.58 9.8 10.5 0.85 9.3 10.5 1.1 1 0 0 1 1 1 0 Myc amino-terminal region PPP4R2 PF09184.9 NM_009767.2_2 - 1.3 8.4 13.1 2 7.8 13.1 1.2 1 0 0 1 1 1 0 PPP4R2 TFIIA PF03153.11 NM_009767.2_2 - 4.8 6.9 8.5 6.8 6.4 8.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Radial_spoke PF04712.10 NM_009767.2_2 - 7.1 5.3 12.9 11 4.7 12.9 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein DUF2360 PF10152.7 NM_009767.2_2 - 9.3 6.5 7.0 15 5.9 7.0 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) RabGAP-TBC PF00566.16 NM_026254.2_2 - 9.2e-19 67.8 1.3 1.4e-18 67.2 1.3 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.18 NM_026254.2_2 - 3.9e-07 30.4 0.0 8.5e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain SSXT PF05030.10 NM_178750.5_3 - 2.1e-31 107.2 5.0 3.7e-31 106.4 5.0 1.4 1 0 0 1 1 1 1 SSXT protein (N-terminal region) DUF2205 PF10224.7 NM_019708.4_1 - 2e-26 91.7 3.6 2.9e-26 91.1 3.6 1.2 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) IncA PF04156.12 NM_019708.4_1 - 0.028 14.1 2.1 0.039 13.6 2.1 1.1 1 0 0 1 1 1 0 IncA protein bZIP_1 PF00170.19 NM_019708.4_1 - 0.055 13.4 0.8 0.11 12.5 0.8 1.5 1 0 0 1 1 1 0 bZIP transcription factor DUF972 PF06156.11 NM_019708.4_1 - 0.17 12.4 3.4 0.26 11.8 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) HALZ PF02183.16 NM_019708.4_1 - 0.18 11.9 7.4 0.65 10.1 2.3 2.6 1 1 1 2 2 2 0 Homeobox associated leucine zipper FlaC_arch PF05377.9 NM_019708.4_1 - 0.23 11.8 1.1 0.41 10.9 1.1 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) CENP-H PF05837.10 NM_019708.4_1 - 0.28 11.5 3.2 0.42 10.9 3.2 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 NM_019708.4_1 - 1.6 9.1 9.1 1.6 9.1 6.4 2.0 2 0 0 2 2 2 0 Cell division protein ZapB Arm PF00514.21 NM_008729.2_1 - 8.7e-46 152.5 5.7 1.1e-08 34.7 0.1 8.7 8 0 0 8 8 8 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 NM_008729.2_1 - 7.1e-07 29.4 0.5 0.013 15.7 0.1 3.3 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.20 NM_008729.2_1 - 0.00064 19.6 2.7 0.85 9.9 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.4 NM_008729.2_1 - 0.017 15.5 3.3 22 5.5 0.1 4.7 4 1 0 4 4 4 0 HEAT-like repeat Atx10homo_assoc PF09759.7 NM_008729.2_1 - 0.059 13.3 0.6 1.3 9.0 0.0 3.1 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Adaptin_N PF01602.18 NM_008729.2_1 - 0.066 11.6 0.0 1 7.7 0.0 2.0 2 0 0 2 2 2 0 Adaptin N terminal region Lectin_C PF00059.19 NM_001161741.1_1 - 1.8e-07 31.7 2.1 2.5e-07 31.3 1.4 1.6 1 1 1 2 2 2 1 Lectin C-type domain Collagen PF01391.16 NM_007733.2_2 - 3.5e-96 314.8 416.2 3.5e-09 36.2 27.2 15.3 4 4 11 15 15 15 15 Collagen triple helix repeat (20 copies) Laminin_G_3 PF13385.4 NM_007733.2_2 - 0.024 14.7 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily PIP5K PF01504.16 NM_198191.2_2 - 9e-63 211.9 0.0 1.2e-62 211.6 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase SH3_1 PF00018.26 NM_001313936.1_1 - 1e-33 114.5 0.9 1.4e-15 56.5 0.0 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 NM_001313936.1_1 - 3.3e-31 106.8 0.2 2.5e-14 52.7 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.15 NM_001313936.1_1 - 5.8e-27 93.0 0.0 7.1e-15 54.3 0.0 2.8 3 0 0 3 3 3 2 Variant SH3 domain SH2 PF00017.22 NM_001313936.1_1 - 5.5e-24 83.9 0.0 9.2e-24 83.2 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.4 NM_001313936.1_1 - 0.021 14.1 0.0 0.034 13.4 0.0 1.2 1 0 0 1 1 1 0 SH2 domain hSH3 PF14603.4 NM_001313936.1_1 - 0.062 13.7 0.0 0.18 12.2 0.0 1.7 2 0 0 2 2 2 0 Helically-extended SH3 domain UBA_5 PF16577.3 NM_001313936.1_1 - 0.13 12.3 0.0 0.35 10.9 0.0 1.7 1 0 0 1 1 1 0 UBA domain SH3_3 PF08239.9 NM_001313936.1_1 - 0.16 12.1 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain Glyco_transf_64 PF09258.8 NM_010163.3_3 - 5.7e-98 327.0 0.2 8.3e-98 326.5 0.2 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.13 NM_010163.3_3 - 7.5e-57 192.7 0.0 1e-56 192.3 0.0 1.2 1 0 0 1 1 1 1 Exostosin family 7tm_4 PF13853.4 NM_146297.2_1 - 2.1e-53 181.7 18.8 2.6e-53 181.4 18.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146297.2_1 - 4.1e-23 81.8 20.8 1.1e-22 80.4 20.8 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_146870.2_2 - 1.2e-45 156.3 23.6 1.7e-45 155.8 23.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146870.2_2 - 3e-17 62.6 31.8 1.3e-16 60.5 31.7 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FRG2 PF15315.4 NM_001004178.1_2 - 5.6e-33 114.5 13.4 4.6e-31 108.3 13.4 2.2 1 1 0 1 1 1 1 Facioscapulohumeral muscular dystrophy candidate 2 CDC45 PF02724.12 NM_001004178.1_2 - 0.22 9.6 1.8 0.3 9.2 1.8 1.1 1 0 0 1 1 1 0 CDC45-like protein V1R PF03402.12 NM_134171.1_1 - 4.9e-52 177.0 22.7 5.9e-52 176.8 22.7 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TctB PF07331.9 NM_134171.1_1 - 0.018 15.2 1.7 0.018 15.2 1.7 2.4 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family VIT_2 PF13757.4 NM_182636.4_3 - 1.4e-30 104.9 0.0 2.7e-30 103.9 0.0 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.4 NM_182636.4_3 - 7.1e-28 97.3 0.0 1.1e-27 96.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.8 NM_182636.4_3 - 5e-05 23.4 0.0 8.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain NAD_Gly3P_dh_N PF01210.21 NM_175380.5_1 - 2e-51 174.0 0.3 3.2e-51 173.3 0.3 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.12 NM_175380.5_1 - 5.5e-49 166.0 0.1 8.7e-49 165.3 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus FH2 PF02181.21 NM_001205355.1_2 - 1.3e-92 310.7 12.8 1.7e-92 310.3 12.8 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain TPX2 PF06886.9 NM_001205355.1_2 - 2.5 8.3 8.2 6.1 7.0 8.2 1.6 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) Ribosomal_L34 PF00468.15 NM_026121.3_2 - 0.026 14.4 0.5 0.062 13.1 0.5 1.6 1 0 0 1 1 1 0 Ribosomal protein L34 BAG PF02179.14 NM_026121.3_3 - 1.7e-16 60.2 3.2 2.6e-16 59.7 3.2 1.3 1 0 0 1 1 1 1 BAG domain Peptidase_M24 PF00557.22 NM_025633.3_1 - 3.4e-54 183.6 0.0 4.2e-54 183.3 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 7tm_4 PF13853.4 NM_147087.2_1 - 1.6e-108 362.6 24.6 1.8e-108 362.4 24.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147087.2_1 - 5.3e-22 78.2 20.7 8.4e-22 77.5 20.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147087.2_1 - 8.3e-05 21.9 20.1 0.00013 21.3 20.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Serpentine_r_xa PF03383.13 NM_147087.2_1 - 0.011 15.6 4.6 0.011 15.6 4.6 2.9 1 1 1 3 3 3 0 Caenorhabditis serpentine receptor-like protein, class xa zf-H2C2_2 PF13465.4 NM_001039231.3_1 - 3.2e-87 283.3 126.5 1.9e-09 37.4 1.7 18.4 17 1 0 17 17 17 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001039231.3_1 - 2.5e-26 90.5 157.2 0.00013 22.1 4.2 16.1 16 0 0 16 16 16 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001039231.3_1 - 4.5e-22 76.7 158.8 0.0011 19.5 2.7 17.2 18 0 0 18 18 17 10 C2H2-type zinc finger KRAB PF01352.25 NM_001039231.3_1 - 9.7e-21 73.0 0.0 1.8e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 KRAB box Csm1 PF12539.6 NM_001039231.3_1 - 0.0024 18.3 3.5 39 4.8 0.1 5.2 2 2 1 5 5 5 0 Chromosome segregation protein Csm1/Pcs1 Zn-ribbon_8 PF09723.8 NM_001039231.3_1 - 0.0061 16.5 77.0 0.1 12.6 3.7 9.1 5 2 4 9 9 9 7 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001039231.3_1 - 0.0093 16.1 1.0 0.0093 16.1 1.0 13.5 16 0 0 16 16 15 3 Zinc-finger double-stranded RNA-binding C1_4 PF07975.10 NM_001039231.3_1 - 0.015 15.5 3.8 0.015 15.5 3.8 9.2 4 3 5 9 9 9 0 TFIIH C1-like domain zf-C2H2_6 PF13912.4 NM_001039231.3_1 - 0.015 15.1 123.2 0.13 12.1 0.9 15.8 15 1 0 15 15 14 0 C2H2-type zinc finger DUF3268 PF11672.6 NM_001039231.3_1 - 0.4 10.9 61.8 0.5 10.6 2.2 7.7 5 2 2 8 8 8 0 zinc-finger-containing domain RNA_POL_M_15KD PF02150.14 NM_001039231.3_1 - 0.83 9.5 42.1 24 4.8 0.1 11.4 11 0 0 11 11 11 0 RNA polymerases M/15 Kd subunit DnaB PF00772.19 NM_001039231.3_2 - 0.00097 19.0 5.7 24 4.9 0.1 6.3 7 0 0 7 7 7 1 DnaB-like helicase N terminal domain Baculo_LEF-11 PF06385.10 NM_001039231.3_2 - 0.05 14.0 19.1 32 5.0 0.2 6.8 2 2 5 7 7 7 0 Baculovirus LEF-11 protein ATR13 PF16829.3 NM_001039231.3_2 - 0.18 12.0 8.5 14 6.0 0.5 4.7 2 2 1 4 4 4 0 Avirulence protein ATR13, RxLR effector Linker_histone PF00538.17 NM_001039231.3_2 - 2.2 8.5 9.1 90 3.4 0.0 6.0 6 1 2 8 8 8 0 linker histone H1 and H5 family zf-H2C2_2 PF13465.4 NM_001039231.3_3 - 7.7e-11 41.8 59.7 8e-05 22.8 4.8 7.2 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001039231.3_3 - 6.7e-07 29.3 58.8 0.00027 21.1 3.0 6.2 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001039231.3_3 - 0.2 12.5 47.2 0.13 13.0 2.6 6.1 5 0 0 5 5 5 0 C2H2-type zinc finger FAM117 PF15388.4 NM_001286729.1_2 - 4.5e-128 426.8 17.9 7.8e-128 426.0 17.9 1.4 1 0 0 1 1 1 1 Protein Family FAM117 ETRAMP PF09716.8 NM_170688.2_1 - 0.021 14.7 0.0 1.4 8.9 0.0 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Ank_2 PF12796.5 NM_170688.2_2 - 6.4e-145 472.0 48.6 1.3e-16 60.8 1.2 11.8 2 2 9 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.28 NM_170688.2_2 - 5.5e-134 431.2 64.7 1.7e-07 31.3 0.1 23.3 22 1 1 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 NM_170688.2_2 - 4.1e-123 400.2 58.6 9.1e-11 41.9 0.4 16.4 4 3 14 19 19 19 19 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_170688.2_2 - 2.4e-113 368.0 45.3 9.1e-12 44.9 0.0 16.5 4 4 13 18 18 18 18 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_170688.2_2 - 2e-107 337.9 35.9 0.00018 21.6 0.0 24.1 24 0 0 24 24 24 21 Ankyrin repeat ZU5 PF00791.18 NM_170688.2_2 - 4.3e-33 113.4 0.9 5.6e-27 93.8 0.0 2.6 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 NM_170688.2_2 - 3.5e-21 75.0 0.0 7.5e-21 74.0 0.0 1.6 1 0 0 1 1 1 1 Death domain AdoHcyase PF05221.15 NM_021414.6_3 - 1.2e-121 405.3 0.0 5e-65 219.4 0.1 2.1 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.19 NM_021414.6_3 - 8e-81 269.7 2.1 1.1e-80 269.3 2.1 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.17 NM_021414.6_3 - 1.1e-08 34.5 0.1 1.9e-08 33.7 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.17 NM_021414.6_3 - 0.0012 18.1 0.6 0.0027 16.9 0.6 1.4 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.18 NM_021414.6_3 - 0.0018 18.2 0.1 0.0037 17.2 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.10 NM_021414.6_3 - 0.0025 17.3 0.0 0.0041 16.6 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.4 NM_021414.6_3 - 0.027 14.8 0.4 0.052 13.9 0.4 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.16 NM_021414.6_3 - 0.046 13.9 0.1 0.095 12.8 0.1 1.5 1 1 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.19 NM_021414.6_3 - 0.06 12.5 0.2 0.13 11.4 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SR-25 PF10500.7 NM_021414.6_3 - 0.56 9.6 12.0 0.82 9.1 12.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DEC-1_N PF04625.11 NM_021414.6_3 - 0.83 8.5 7.4 1.2 7.9 7.4 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region GTP-bdg_M PF16360.3 NM_145147.5_3 - 6.3e-14 52.2 6.8 6.3e-14 52.2 6.8 1.9 2 0 0 2 2 2 1 GTP-binding GTPase Middle Region MMR_HSR1 PF01926.21 NM_145147.5_3 - 2.8e-13 49.8 0.0 5.2e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP-bdg_N PF13167.4 NM_145147.5_3 - 2.8e-11 43.8 0.0 6.4e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal FeoB_N PF02421.16 NM_145147.5_3 - 0.0087 15.5 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B PduV-EutP PF10662.7 NM_145147.5_3 - 0.01 15.4 0.0 0.053 13.1 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.4 NM_145147.5_3 - 0.032 14.5 0.2 0.068 13.4 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain Dynamin_N PF00350.21 NM_145147.5_3 - 0.049 13.5 0.0 0.12 12.3 0.0 1.6 1 1 0 1 1 1 0 Dynamin family MobB PF03205.12 NM_145147.5_3 - 0.061 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TniB PF05621.9 NM_145147.5_3 - 0.096 11.7 0.0 0.2 10.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.25 NM_145147.5_3 - 0.12 12.8 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.4 NM_145147.5_3 - 0.26 11.6 0.0 0.44 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain BNR PF02012.18 NM_011261.2_1 - 5.6e-23 77.0 47.8 0.53 10.4 0.2 16.0 15 0 0 15 15 15 10 BNR/Asp-box repeat EGF_2 PF07974.11 NM_011261.2_1 - 5.4e-22 77.7 163.9 0.00044 20.4 10.4 9.4 9 0 0 9 9 9 8 EGF-like domain CHB_HEX_C PF03174.11 NM_011261.2_1 - 7.7e-08 32.1 0.1 5.9 6.8 0.0 10.3 14 0 0 14 14 14 1 Chitobiase/beta-hexosaminidase C-terminal domain Reeler PF02014.14 NM_011261.2_1 - 1.7e-07 31.9 0.0 5.5e-07 30.3 0.0 1.9 1 0 0 1 1 1 1 Reeler domain hEGF PF12661.5 NM_011261.2_1 - 0.75 10.4 114.9 0.0092 16.5 9.0 9.7 9 0 0 9 9 9 0 Human growth factor-like EGF EB PF01683.16 NM_011261.2_1 - 4 7.6 91.2 0.043 13.9 3.4 9.7 9 0 0 9 9 9 0 EB module Pro_isomerase PF00160.19 NM_001252445.1_1 - 2.7e-51 173.8 0.1 6.8e-51 172.5 0.0 1.7 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.10 NM_001252445.1_1 - 1.5e-05 24.4 0.9 4.5e-05 22.8 0.0 2.1 2 1 0 2 2 2 1 Rtf2 RING-finger zf-NOSIP PF15906.3 NM_001252445.1_1 - 0.0082 16.1 0.1 0.041 13.9 0.0 2.1 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.13 NM_001252445.1_1 - 0.011 15.7 0.0 0.042 13.9 0.0 2.0 1 0 0 1 1 1 0 U-box domain RRP7 PF12923.5 NM_001252445.1_1 - 1.7 8.7 5.1 18 5.4 0.2 2.4 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) zf-C4 PF00105.16 NM_001043354.2_3 - 5.3e-32 110.0 12.3 5.3e-32 110.0 12.3 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001043354.2_3 - 2.5e-23 82.6 1.5 4.6e-23 81.7 1.5 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C3HC4_2 PF13923.4 NM_026205.3_1 - 6.1e-09 35.5 14.0 6.1e-09 35.5 14.0 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_026205.3_1 - 1e-07 32.0 15.4 1e-07 32.0 15.4 3.6 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_3 PF13920.4 NM_026205.3_1 - 1.3e-07 31.2 12.8 1.3e-07 31.2 12.8 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_026205.3_1 - 2.2e-07 30.7 9.0 2.2e-07 30.7 9.0 2.4 2 0 0 2 2 2 1 RING-type zinc-finger U-box PF04564.13 NM_026205.3_1 - 6.8e-07 29.3 0.0 7.4e-06 25.9 0.0 2.4 2 0 0 2 2 2 1 U-box domain zf-C3HC4 PF00097.23 NM_026205.3_1 - 1.8e-06 27.6 14.0 1.8e-06 27.6 14.0 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.16 NM_026205.3_1 - 1.2e-05 25.8 5.3 1.2e-05 25.8 5.3 3.2 1 1 2 3 3 3 1 TRAF-type zinc finger zf-RING_5 PF14634.4 NM_026205.3_1 - 2e-05 24.3 13.6 2e-05 24.3 13.6 3.1 2 1 1 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 NM_026205.3_1 - 2.1e-05 24.5 12.8 7.1e-05 22.8 12.3 2.3 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.4 NM_026205.3_1 - 2.7e-05 23.8 11.8 2.7e-05 23.8 11.8 2.8 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 Sina PF03145.14 NM_026205.3_1 - 0.00014 21.8 7.1 0.00014 21.8 7.1 1.7 2 0 0 2 2 2 1 Seven in absentia protein family zf-rbx1 PF12678.5 NM_026205.3_1 - 0.00034 20.7 13.1 0.00034 20.7 13.1 3.2 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.5 NM_026205.3_1 - 0.0031 17.4 6.2 0.0031 17.4 6.2 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.4 NM_026205.3_1 - 0.043 13.6 8.2 0.069 12.9 6.9 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein HTH_Tnp_IS630 PF01710.14 NM_026205.3_1 - 0.053 13.4 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 Transposase Peptidase_M23 PF01551.20 NM_010702.2_3 - 1.9e-05 24.6 0.0 2.7e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M23 LSM PF01423.20 NM_026032.1_1 - 2.7e-14 52.4 0.2 4.2e-14 51.8 0.2 1.3 1 0 0 1 1 1 1 LSM domain SNF2_N PF00176.21 NM_001284354.1_1 - 1e-121 405.9 0.1 1e-121 405.9 0.1 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain Linker_histone PF00538.17 NM_001284354.1_1 - 7.1e-16 58.2 0.0 3.2e-15 56.1 0.0 2.3 1 0 0 1 1 1 1 linker histone H1 and H5 family Helicase_C PF00271.29 NM_001284354.1_1 - 1.8e-07 31.4 0.0 5.4e-07 29.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 NM_001284354.1_1 - 7.3e-06 25.6 9.8 7.3e-06 25.6 9.8 4.2 3 1 0 3 3 3 1 PHD-finger zf-C3HC4_3 PF13920.4 NM_001284354.1_1 - 0.00017 21.2 10.2 0.00017 21.2 10.2 3.2 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001284354.1_1 - 0.0014 18.5 7.3 0.0014 18.5 7.3 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_001284354.1_1 - 0.0024 18.0 11.0 0.0024 18.0 11.0 3.7 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.23 NM_001284354.1_1 - 0.0048 16.6 11.0 0.0048 16.6 11.0 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_001284354.1_1 - 0.18 11.5 12.2 0.39 10.5 9.9 2.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 NM_001284354.1_1 - 2.6 7.9 24.9 0.0091 15.8 10.6 3.6 2 1 0 2 2 2 0 zinc-RING finger domain Grg1 PF11034.6 NM_001003963.4_2 - 0.15 12.1 3.3 0.25 11.5 3.3 1.2 1 0 0 1 1 1 0 Glucose-repressible protein Grg1 DNA_methylase PF00145.15 NM_001003963.4_3 - 3.1e-14 52.9 0.0 3.6e-12 46.1 0.0 2.5 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase PWWP PF00855.15 NM_001003963.4_3 - 2.1e-11 44.0 0.4 2.1e-11 44.0 0.4 2.1 3 0 0 3 3 3 1 PWWP domain Peptidase_C2 PF00648.19 NM_009794.3_1 - 3.1e-129 430.1 0.0 4.3e-129 429.6 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 NM_009794.3_1 - 3.7e-54 182.7 0.0 6e-54 182.0 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 NM_009794.3_1 - 2.5e-09 35.9 2.4 0.019 14.4 0.0 4.4 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.4 NM_009794.3_1 - 7.9e-09 34.6 0.8 0.06 13.2 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 NM_009794.3_1 - 1.5e-08 34.1 1.0 2.1e-07 30.5 0.2 2.7 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.4 NM_009794.3_1 - 0.0023 18.3 6.9 2.6 8.4 0.5 4.1 4 1 0 4 4 4 2 EF-hand domain pair Methyltransf_3 PF01596.15 NM_026965.2_3 - 8e-55 185.2 0.0 1.2e-54 184.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 NM_026965.2_3 - 4.7e-11 43.5 0.0 8.1e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_026965.2_3 - 0.0049 17.4 0.0 0.0091 16.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.5 NM_026965.2_3 - 0.015 15.1 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.4 NM_026965.2_3 - 0.018 14.7 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.17 NM_026965.2_3 - 0.052 13.2 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TFIIIC_delta PF12657.5 NM_172977.3_2 - 1.2e-42 145.8 0.0 7.4e-42 143.2 0.0 2.0 2 0 0 2 2 2 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.5 NM_172977.3_2 - 1.5e-09 37.6 1.7 4.2e-09 36.1 1.7 1.7 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex TSP_C PF05735.10 NM_016685.2_1 - 1.4e-97 325.2 0.6 1.9e-97 324.9 0.6 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 NM_016685.2_1 - 6.5e-61 201.6 134.4 1.8e-12 46.6 12.6 9.3 7 2 1 8 8 8 7 Thrombospondin type 3 repeat COMP PF11598.6 NM_016685.2_1 - 1.2e-18 67.2 2.6 2.2e-18 66.3 2.6 1.5 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein EGF_CA PF07645.13 NM_016685.2_1 - 2.5e-14 53.1 55.9 1.2e-10 41.2 8.8 6.0 5 0 0 5 5 5 3 Calcium-binding EGF domain cEGF PF12662.5 NM_016685.2_1 - 5.9e-09 35.6 27.1 5.3e-05 22.9 0.2 5.3 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_3 PF12947.5 NM_016685.2_1 - 0.0004 20.4 16.7 0.0019 18.2 5.4 6.0 6 0 0 6 6 6 3 EGF domain EGF_MSP1_1 PF12946.5 NM_016685.2_1 - 0.0037 17.1 2.4 0.0037 17.1 2.4 4.6 4 0 0 4 4 4 1 MSP1 EGF domain 1 RsfS PF02410.13 NM_029353.1_3 - 3.5e-26 91.3 0.0 4.5e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation Glyco_hydro_18 PF00704.26 NM_001293672.1_3 - 2.6e-34 119.3 2.0 3.6e-34 118.8 2.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Esterase PF00756.18 NM_001285423.1_2 - 3.8e-70 236.2 0.0 4.9e-70 235.9 0.0 1.1 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.5 NM_001285423.1_2 - 8.9e-05 21.4 0.0 0.00014 20.7 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.19 NM_001285423.1_2 - 0.00013 21.3 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.7 NM_001285423.1_2 - 0.00034 20.1 0.0 0.0016 17.8 0.0 1.9 1 1 0 1 1 1 1 Esterase PHB depolymerase AXE1 PF05448.10 NM_001285423.1_2 - 0.00097 17.8 0.0 0.0014 17.2 0.0 1.1 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.6 NM_001285423.1_2 - 0.0021 17.3 0.0 0.0031 16.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.14 NM_001285423.1_2 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.11 NM_001285423.1_2 - 0.13 12.0 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Haemadin PF09065.8 NM_001285423.1_3 - 0.91 9.2 5.9 2 8.2 0.2 2.7 2 0 0 2 2 2 0 Haemadin Gal-bind_lectin PF00337.20 NM_010706.2_2 - 1.5e-77 257.5 0.5 6.9e-40 135.6 0.2 2.1 2 0 0 2 2 2 2 Galactoside-binding lectin zf-C4 PF00105.16 NM_001163504.1_1 - 1.7e-28 98.7 14.3 1.7e-28 98.7 14.3 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001163504.1_1 - 7.1e-25 87.7 1.5 1.2e-24 87.0 1.0 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor MAP17 PF15807.3 NM_001164557.1_1 - 2.1e-31 108.6 0.0 3.3e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Phage_holin_3_6 PF07332.9 NM_001164557.1_1 - 4.4 7.3 6.9 7.8 6.4 6.9 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Bap31 PF05529.10 NM_007530.3_1 - 9e-66 221.2 7.0 1.4e-65 220.6 7.0 1.3 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like Lebercilin PF15619.4 NM_007530.3_1 - 0.24 10.9 20.9 0.37 10.3 20.9 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease IncA PF04156.12 NM_007530.3_1 - 0.63 9.7 8.6 1.4 8.5 8.6 1.6 1 0 0 1 1 1 0 IncA protein Syntaxin_2 PF14523.4 NM_007530.3_1 - 7.4 6.9 15.3 7.9 6.8 12.7 2.0 1 1 1 2 2 2 0 Syntaxin-like protein V-set PF07686.15 NM_009857.1_1 - 3e-14 52.9 0.2 5.1e-14 52.2 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_009857.1_1 - 2.4e-05 24.7 0.0 6.8e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_009857.1_1 - 4.9e-05 23.2 0.1 0.00029 20.7 0.1 2.0 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_009857.1_1 - 0.00016 21.7 0.1 0.00032 20.7 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_5 PF16681.3 NM_009857.1_1 - 0.026 14.8 0.1 0.05 13.9 0.1 1.4 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain LRR_4 PF12799.5 NM_183320.3_2 - 0.21 11.9 11.5 11 6.4 0.1 5.4 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) Pkinase PF00069.23 NM_001162540.1_3 - 3.8e-63 213.2 0.0 5.8e-63 212.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001162540.1_3 - 2.6e-34 118.6 0.1 3.5e-34 118.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001162540.1_3 - 2.5e-10 40.0 0.1 3.3e-10 39.6 0.1 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001162540.1_3 - 0.0079 15.4 0.3 0.016 14.4 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001162540.1_3 - 0.015 15.1 0.2 0.031 14.0 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family V-set PF07686.15 NM_178687.2_3 - 3.6e-19 68.8 1.5 1.7e-08 34.4 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_178687.2_3 - 7.3e-14 52.0 2.0 7.6e-07 29.5 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_178687.2_3 - 3.1e-08 33.4 0.1 0.0012 18.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 NM_178687.2_3 - 3.4e-08 33.4 1.7 0.00097 19.1 0.1 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_178687.2_3 - 8e-07 29.2 4.7 0.0027 17.9 0.3 3.2 2 2 0 2 2 2 2 Immunoglobulin domain Herpes_gE PF02480.14 NM_178687.2_3 - 0.0096 14.6 0.0 3.1 6.3 0.0 2.8 2 1 1 3 3 3 1 Alphaherpesvirus glycoprotein E stn_TNFRSF12A PF12191.6 NM_178687.2_3 - 0.012 15.7 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain TMEM154 PF15102.4 NM_178687.2_3 - 0.031 14.0 0.9 0.058 13.2 0.9 1.3 1 0 0 1 1 1 0 TMEM154 protein family LAX PF15681.3 NM_178687.2_3 - 0.04 12.5 0.1 0.069 11.7 0.1 1.3 1 0 0 1 1 1 0 Lymphocyte activation family X Syndecan PF01034.18 NM_178687.2_3 - 0.12 12.2 0.1 0.23 11.2 0.1 1.4 1 0 0 1 1 1 0 Syndecan domain Adeno_E3_CR2 PF02439.13 NM_178687.2_3 - 0.18 11.5 1.5 0.39 10.4 1.5 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Lamp PF01299.15 NM_178687.2_3 - 3.4 7.0 6.2 0.5 9.7 2.3 1.5 2 0 0 2 2 2 0 Lysosome-associated membrane glycoprotein (Lamp) FSIP1 PF15554.4 NM_027759.3_1 - 3.7e-153 510.2 19.5 3.6e-152 507.0 19.5 1.9 1 1 0 1 1 1 1 FSIP1 family ArfGap PF01412.16 NM_001177706.1_1 - 7.2e-33 113.0 0.1 1.8e-32 111.7 0.1 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-piccolo PF05715.11 NM_001177706.1_1 - 0.025 14.6 0.6 0.095 12.7 0.6 2.0 1 0 0 1 1 1 0 Piccolo Zn-finger LRR_8 PF13855.4 NM_178005.4_3 - 6.5e-45 150.6 39.3 1.2e-15 56.8 6.2 4.4 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 NM_178005.4_3 - 3.7e-23 81.0 38.7 4.8e-05 23.5 0.3 6.5 5 1 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_178005.4_3 - 3.8e-09 36.1 12.6 0.0006 19.2 0.5 3.3 1 1 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.31 NM_178005.4_3 - 0.76 10.3 35.6 6.9 7.4 1.4 9.3 8 2 1 9 9 9 0 Leucine Rich Repeat LRRNT PF01462.16 NM_178005.4_3 - 9.8 5.8 10.9 0.092 12.3 2.2 2.3 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain zf-H2C2_2 PF13465.4 NM_001243118.1_1 - 2.3e-98 318.5 113.2 9.4e-10 38.4 1.9 13.7 13 0 0 13 13 13 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001243118.1_1 - 1.3e-45 151.3 135.6 4.5e-06 26.7 1.1 13.3 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001243118.1_1 - 9.4e-31 103.7 129.5 0.00099 19.6 2.5 13.7 13 0 0 13 13 13 12 C2H2-type zinc finger KRAB PF01352.25 NM_001243118.1_1 - 3.3e-20 71.3 0.1 5.2e-20 70.7 0.1 1.3 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001243118.1_1 - 7.7e-15 54.3 109.2 5.7e-05 22.8 0.8 13.6 12 2 0 12 12 12 8 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 NM_001243118.1_1 - 1.3e-05 25.8 56.8 0.41 11.3 2.3 6.5 4 2 2 6 6 6 6 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_001243118.1_1 - 1.9e-05 24.2 77.4 0.052 13.2 1.3 12.3 12 0 0 12 12 12 7 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 NM_001243118.1_1 - 7.2e-05 22.7 73.0 0.048 13.7 3.9 9.6 5 4 4 10 10 10 4 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001243118.1_1 - 0.00054 20.1 2.0 0.00054 20.1 2.0 11.7 12 0 0 12 12 11 5 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_001243118.1_1 - 0.011 15.9 56.8 0.28 11.4 4.5 7.0 3 2 5 8 8 8 0 zinc-finger-containing domain GATA PF00320.25 NM_001243118.1_1 - 0.33 10.5 53.7 0.37 10.3 0.3 11.1 11 1 0 11 11 11 0 GATA zinc finger SprT-like PF10263.7 NM_001243118.1_1 - 0.79 9.4 82.2 0.2 11.3 3.5 6.7 1 1 5 6 6 6 0 SprT-like family zf-H2C2_2 PF13465.4 NM_001243118.1_2 - 5.2e-05 23.4 9.7 0.0013 18.9 2.8 3.6 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001243118.1_2 - 0.00012 22.2 8.1 0.0029 17.9 0.5 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001243118.1_2 - 0.7 10.7 12.3 0.31 11.8 0.3 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger 7tm_4 PF13853.4 NM_146706.1_1 - 2.7e-50 171.5 8.4 3.2e-50 171.3 8.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146706.1_1 - 3.7e-25 88.6 12.6 6.6e-25 87.7 12.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146706.1_1 - 0.00069 18.9 8.6 0.00093 18.5 8.5 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx IL7 PF01415.14 NM_001313888.1_2 - 5.9e-45 152.5 8.2 9.2e-45 151.8 8.2 1.3 1 0 0 1 1 1 1 Interleukin 7/9 family 7tm_4 PF13853.4 NM_146597.2_1 - 1.8e-52 178.7 19.4 2.8e-52 178.1 19.4 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146597.2_1 - 2.3e-26 92.5 22.1 1.1e-25 90.3 22.1 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146597.2_1 - 2.2e-07 30.4 21.8 4.7e-07 29.3 21.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4577 PF15145.4 NM_146597.2_1 - 0.065 13.1 3.1 0.22 11.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) MITF_TFEB_C_3_N PF15951.3 NM_001105197.1_1 - 1.5e-54 184.6 3.5 1.5e-54 184.6 3.5 1.8 2 0 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 NM_001105197.1_1 - 2.2e-17 64.1 3.4 2.2e-17 64.1 3.4 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.24 NM_001105197.1_1 - 8.1e-16 57.6 0.7 8.1e-16 57.6 0.7 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF4205 PF13898.4 NM_024185.4_2 - 5.2e-54 183.3 0.0 2.6e-51 174.5 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4205) CK_II_beta PF01214.16 NM_001303446.1_2 - 3.9e-86 287.4 0.0 4.8e-86 287.1 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CCDC24 PF15669.3 NM_001303446.1_2 - 0.17 11.6 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Pkinase PF00069.23 NM_028778.4_1 - 2.5e-75 253.1 0.0 3.4e-75 252.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_028778.4_1 - 7e-43 146.6 0.0 1e-42 146.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_028778.4_1 - 3.7e-05 23.0 0.0 5.6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_028778.4_1 - 0.0002 20.6 0.2 0.00042 19.6 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 NM_028778.4_1 - 0.00029 20.4 0.1 0.00047 19.7 0.1 1.2 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.4 NM_028778.4_1 - 0.0054 16.3 0.6 0.86 9.1 0.0 2.2 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.21 NM_028778.4_1 - 0.088 12.6 1.9 0.17 11.7 0.3 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family Ras PF00071.20 NM_001161773.1_3 - 2.4e-55 186.4 0.0 3e-55 186.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001161773.1_3 - 1.3e-21 76.9 0.0 1.9e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001161773.1_3 - 4.6e-06 26.1 0.0 8.9e-06 25.1 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family T-box_assoc PF16176.3 NM_010136.3_1 - 8.2e-98 326.8 0.4 1.7e-97 325.8 0.4 1.6 1 0 0 1 1 1 1 T-box transcription factor-associated T-box PF00907.20 NM_010136.3_1 - 2.6e-75 252.6 1.1 4.6e-75 251.7 1.1 1.4 1 0 0 1 1 1 1 T-box NqrM PF04400.11 NM_010136.3_1 - 4.9 6.8 5.8 12 5.6 5.8 1.6 1 0 0 1 1 1 0 (Na+)-NQR maturation NqrM Yae1_N PF09811.7 NM_010136.3_3 - 0.018 14.6 5.0 0.036 13.6 5.0 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal DAN PF03045.13 NM_009887.2_3 - 5e-28 97.2 7.2 7.9e-28 96.6 7.2 1.3 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.20 NM_009887.2_3 - 0.0017 18.5 8.0 0.003 17.7 8.0 1.3 1 0 0 1 1 1 1 Cystine-knot domain EF-hand_7 PF13499.4 NM_145549.1_3 - 6.4e-14 52.0 1.2 1.4e-08 35.0 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_145549.1_3 - 9.2e-10 37.2 4.6 0.00076 18.7 0.2 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 NM_145549.1_3 - 4.1e-06 26.3 5.0 0.033 13.8 0.1 3.7 2 1 2 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_145549.1_3 - 4.6e-06 26.0 5.1 0.047 13.5 0.2 4.2 4 1 1 5 5 5 2 EF-hand domain EF-hand_5 PF13202.4 NM_145549.1_3 - 6.1e-06 25.4 4.0 0.0038 16.6 0.2 3.0 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.5 NM_145549.1_3 - 0.00019 21.2 1.1 0.17 11.7 0.1 3.4 2 1 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF_assoc_2 PF08356.10 NM_145549.1_3 - 0.024 14.5 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 EF hand associated EFhand_Ca_insen PF08726.8 NM_145549.1_3 - 0.033 14.1 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 Ca2+ insensitive EF hand CC2-LZ PF16516.3 NM_021327.4_1 - 2e-07 31.2 19.9 2e-07 31.2 19.9 5.3 3 2 2 5 5 5 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FlxA PF14282.4 NM_021327.4_1 - 0.0065 16.3 15.3 0.0065 16.3 15.3 4.2 3 1 0 4 4 4 1 FlxA-like protein NPV_P10 PF05531.10 NM_021327.4_1 - 1.8 9.0 15.8 8.8 6.7 0.4 4.3 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein G-gamma PF00631.20 NM_010320.3_3 - 7.9e-15 54.5 0.0 1.4e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 GGL domain MRP-S23 PF10484.7 NM_001291270.1_3 - 8.3e-43 145.6 0.0 1.2e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S23 MRP-S25 PF13741.4 NM_001291270.1_3 - 1.1e-06 28.3 1.3 0.00044 19.7 0.0 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 Ig_2 PF13895.4 NM_001113238.1_2 - 2.1e-40 136.8 2.4 3.1e-10 40.1 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 NM_001113238.1_2 - 7.4e-37 125.7 0.1 1.6e-12 47.7 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 NM_001113238.1_2 - 7e-19 67.6 0.1 7.1e-10 38.7 0.0 4.7 4 0 0 4 4 4 2 Immunoglobulin I-set domain ig PF00047.23 NM_001113238.1_2 - 1.6e-17 63.3 7.6 1.4e-07 31.5 0.0 5.3 4 2 0 4 4 4 2 Immunoglobulin domain Izumo-Ig PF16706.3 NM_001113238.1_2 - 2.1e-05 24.3 0.3 0.052 13.5 0.0 3.7 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain V-set PF07686.15 NM_001113238.1_2 - 4.7e-05 23.4 6.9 0.07 13.2 0.1 5.2 4 2 1 5 5 5 1 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_001113238.1_2 - 0.00011 22.4 3.9 0.11 12.9 0.0 4.5 5 0 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 NM_001113238.1_2 - 0.0027 17.6 0.0 0.88 9.5 0.0 3.3 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 NM_001113238.1_2 - 0.28 11.4 0.1 0.28 11.4 0.1 4.9 5 1 0 5 5 5 0 T-cell surface glycoprotein CD3 delta chain WD40 PF00400.30 NM_146039.3_2 - 1.9e-06 28.3 0.6 0.059 14.1 0.1 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_146039.3_2 - 0.011 15.8 0.0 0.12 12.6 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Stork_head PF10264.7 NM_001114311.1_2 - 2.5e-31 107.5 0.1 4.4e-31 106.7 0.1 1.4 1 0 0 1 1 1 1 Winged helix Storkhead-box1 domain E1_DerP2_DerF2 PF02221.13 NM_010299.3_3 - 1.4e-31 109.6 0.2 2e-31 109.0 0.2 1.3 1 0 0 1 1 1 1 ML domain zf-H2C2_2 PF13465.4 NM_001310531.1_1 - 6.6e-41 136.8 29.5 3.1e-07 30.4 0.1 8.6 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001310531.1_1 - 5.3e-36 121.0 38.8 1.1e-06 28.7 0.3 8.1 8 0 0 8 8 7 6 Zinc finger, C2H2 type KRAB PF01352.25 NM_001310531.1_1 - 9.5e-22 76.3 0.6 1.7e-21 75.5 0.6 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001310531.1_1 - 1.2e-19 69.1 41.9 0.009 16.6 0.3 8.2 8 0 0 8 8 7 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001310531.1_1 - 1.2e-17 63.2 26.8 0.0021 17.8 0.2 6.6 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001310531.1_1 - 1.1e-11 44.6 15.8 0.17 12.1 0.0 6.9 7 0 0 7 7 6 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001310531.1_1 - 7.3e-09 35.5 20.9 0.0043 17.0 0.7 4.7 2 1 3 5 5 5 4 Zinc ribbon domain XPA_N PF01286.16 NM_001310531.1_1 - 2e-07 30.8 17.2 1.7 8.7 0.2 6.7 6 0 0 6 6 6 1 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001310531.1_1 - 0.00066 20.2 13.9 0.27 11.9 0.6 3.4 1 1 2 3 3 3 2 zinc-ribbon family DZR PF12773.5 NM_001310531.1_1 - 0.003 17.4 18.4 1.3e+02 2.6 14.4 4.2 2 1 0 2 2 2 0 Double zinc ribbon ADK_lid PF05191.12 NM_001310531.1_1 - 0.0041 17.0 11.2 0.16 11.9 0.9 3.9 3 1 1 4 4 4 1 Adenylate kinase, active site lid zf-C2HE PF16278.3 NM_001310531.1_1 - 0.0046 17.2 25.9 3 8.2 0.2 6.9 1 1 6 7 7 7 1 C2HE / C2H2 / C2HC zinc-binding finger PknG_rubred PF16919.3 NM_001310531.1_1 - 0.0056 16.7 8.7 0.25 11.3 0.2 3.4 1 1 1 3 3 3 1 Protein kinase G rubredoxin domain zf-BED PF02892.13 NM_001310531.1_1 - 0.0095 15.8 30.1 2.4 8.2 0.2 7.7 3 2 4 7 7 7 1 BED zinc finger zf-met PF12874.5 NM_001310531.1_1 - 0.0097 16.1 29.3 3.1 8.2 0.2 7.0 7 0 0 7 7 7 1 Zinc-finger of C2H2 type zf-trcl PF13451.4 NM_001310531.1_1 - 0.015 15.1 20.5 6.1 6.7 0.1 6.9 7 0 0 7 7 7 0 Probable zinc-ribbon domain MRP-S23 PF10484.7 NM_001310531.1_1 - 0.019 15.0 0.0 64 3.7 0.0 4.7 2 2 4 6 6 5 0 Mitochondrial ribosomal protein S23 zf-AN1 PF01428.14 NM_001310531.1_1 - 0.021 14.8 19.1 16 5.6 0.1 6.4 6 0 0 6 6 6 0 AN1-like Zinc finger DNA_RNApol_7kD PF03604.11 NM_001310531.1_1 - 0.21 11.2 16.8 7.9 6.1 0.1 6.1 6 0 0 6 6 6 0 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.17 NM_001310531.1_1 - 0.22 11.4 14.1 4.6 7.2 0.6 3.8 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.6 NM_001310531.1_1 - 0.58 10.4 11.0 1.7 8.9 0.1 3.5 2 1 1 4 4 4 0 zinc-finger-containing domain zf-C2H2_11 PF16622.3 NM_001310531.1_1 - 0.74 9.5 28.5 1.9 8.2 2.6 6.3 6 0 0 6 6 6 0 zinc-finger C2H2-type CpXC PF14353.4 NM_001310531.1_1 - 1.5 8.7 13.7 39 4.2 1.0 5.5 1 1 4 5 5 5 0 CpXC protein Ribosomal_L44 PF00935.17 NM_001310531.1_1 - 2.1 8.7 10.9 92 3.5 0.1 5.2 5 0 0 5 5 5 0 Ribosomal protein L44 zf-LYAR PF08790.9 NM_001310531.1_1 - 2.5 8.0 22.8 15 5.5 0.1 6.7 7 0 0 7 7 6 0 LYAR-type C2HC zinc finger TFIIS_C PF01096.16 NM_001310531.1_1 - 2.5 7.9 21.7 15 5.4 0.2 6.3 6 0 0 6 6 6 0 Transcription factor S-II (TFIIS) LIM PF00412.20 NM_001310531.1_1 - 5.3 7.2 19.3 8 6.6 0.7 4.6 3 2 0 3 3 3 0 LIM domain Zn_ribbon_recom PF13408.4 NM_001310531.1_1 - 5.4 7.5 19.0 35 4.9 0.5 5.1 2 1 2 4 4 4 0 Recombinase zinc beta ribbon domain YhfH PF14149.4 NM_001310531.1_1 - 6.4 6.7 20.2 24 4.9 0.1 6.3 7 0 0 7 7 7 0 YhfH-like protein OSTMP1 PF09777.7 NM_001310531.1_1 - 7 5.8 8.0 24 4.1 0.3 2.9 1 1 1 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor MAGE PF01454.17 NM_020280.2_1 - 1.8e-09 37.5 0.0 5.5e-09 35.9 0.0 1.7 1 1 0 1 1 1 1 MAGE family MAGE_N PF12440.6 NM_020280.2_1 - 1.5e-07 31.8 7.0 2.7e-07 31.0 7.0 1.4 1 0 0 1 1 1 1 Melanoma associated antigen family N terminal V-set PF07686.15 NM_001101657.2_3 - 4.9e-14 52.3 0.3 7.2e-14 51.7 0.3 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain V-set_2 PF15910.3 NM_001101657.2_3 - 0.065 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 ICOS V-set domain ig PF00047.23 NM_001101657.2_3 - 0.066 13.3 1.3 1.5 8.9 0.0 3.0 3 0 0 3 3 3 0 Immunoglobulin domain MFAP1 PF06991.9 NM_026220.4_2 - 3.3e-77 259.1 30.4 3.3e-77 259.1 30.4 2.1 2 0 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing PDEase_I PF00233.17 NM_001159956.1_3 - 2.5e-81 272.8 4.2 4.2e-81 272.0 4.2 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.10 NM_001159956.1_3 - 3.1e-31 106.9 0.1 6.4e-31 105.9 0.1 1.6 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal DUF4501 PF14946.4 NM_145557.3_3 - 5.8e-89 296.7 0.0 8.3e-89 296.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4501) Spy1 PF11357.6 NM_001142631.1_1 - 2.6e-59 199.1 6.6 3.6e-59 198.6 6.6 1.2 1 0 0 1 1 1 1 Cell cycle regulatory protein GBP_C PF02841.12 NM_018734.3_2 - 2.3e-123 411.2 23.2 3.4e-123 410.7 23.2 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain GBP PF02263.17 NM_018734.3_2 - 9.6e-122 405.1 0.1 9.6e-122 405.1 0.1 2.0 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain RHD3 PF05879.10 NM_018734.3_2 - 0.0022 16.1 0.0 0.0022 16.1 0.0 2.6 2 1 0 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) Phlebovirus_NSM PF07246.9 NM_018734.3_2 - 0.003 16.8 7.7 0.003 16.8 7.7 1.7 2 0 0 2 2 2 1 Phlebovirus nonstructural protein NS-M MMR_HSR1 PF01926.21 NM_018734.3_2 - 0.0057 16.6 0.0 0.017 15.1 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Pkinase PF00069.23 NM_148945.2_3 - 2.6e-145 482.5 0.0 5.7e-73 245.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_148945.2_3 - 6.8e-77 258.1 0.0 4.4e-41 140.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 NM_148945.2_3 - 7.5e-13 48.3 0.0 1.5e-06 27.6 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.12 NM_148945.2_3 - 1.2e-09 37.6 0.1 6.7e-05 22.2 0.0 2.5 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.22 NM_148945.2_3 - 8.2e-07 29.5 1.8 1.9e-06 28.4 1.8 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.21 NM_148945.2_3 - 0.00034 20.5 0.0 0.49 10.1 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.7 NM_148945.2_3 - 0.014 14.8 0.1 1.2 8.5 0.0 2.5 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL FTA2 PF13095.4 NM_148945.2_3 - 0.017 14.6 0.1 9.1 5.7 0.0 3.0 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 TLD PF07534.14 NM_130885.2_2 - 5.2e-38 130.3 0.4 9.3e-38 129.5 0.4 1.4 1 0 0 1 1 1 1 TLD LysM PF01476.18 NM_130885.2_2 - 5.9e-07 29.4 0.0 1.2e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 LysM domain GRAM PF02893.18 NM_130885.2_2 - 0.023 14.4 0.0 0.058 13.1 0.0 1.6 1 0 0 1 1 1 0 GRAM domain DUF3350 PF11830.6 NM_130885.2_2 - 5.5 7.3 6.7 3 8.1 2.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3350) CBM_21 PF03370.11 NM_138605.3_1 - 1.2e-26 92.9 0.0 2.1e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 NM_138605.3_1 - 4.6e-07 30.2 0.0 1.1e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) ATAD4 PF15321.4 NM_146026.1_3 - 6.8e-22 78.5 0.1 6.8e-22 78.5 0.1 2.4 2 0 0 2 2 2 1 ATPase family AAA domain containing 4 TGS PF02824.19 NM_017404.4_2 - 0.0011 18.9 0.0 0.0053 16.6 0.0 2.0 2 0 0 2 2 2 1 TGS domain Dynamin_M PF01031.18 NM_001276340.1_2 - 2.1e-103 345.3 0.0 3.5e-103 344.6 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.21 NM_001276340.1_2 - 2.7e-54 183.6 0.3 5.8e-54 182.5 0.1 1.7 2 0 0 2 2 2 1 Dynamin family GED PF02212.16 NM_001276340.1_2 - 3.1e-32 110.5 1.5 3.1e-32 110.5 1.5 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 NM_001276340.1_2 - 0.0001 22.2 0.3 0.0006 19.8 0.3 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.4 NM_001276340.1_2 - 0.027 14.7 0.1 0.39 10.9 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain RGS PF00615.17 NM_001199003.1_2 - 6.1e-35 119.9 0.0 1.5e-34 118.7 0.0 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.19 NM_001199003.1_2 - 1.2e-18 66.8 0.0 4.2e-18 65.1 0.0 2.0 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.20 NM_001199003.1_2 - 1.3e-13 50.5 0.1 3.3e-13 49.3 0.1 1.6 1 0 0 1 1 1 1 GGL domain RGS-like PF09128.9 NM_001199003.1_2 - 0.062 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain Fer2 PF00111.25 NM_007996.2_1 - 4.5e-07 29.6 1.0 1.7e-06 27.8 0.3 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain V-set PF07686.15 NM_016982.2_1 - 1.3e-22 79.9 0.0 1.8e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_016982.2_1 - 0.00014 22.3 0.0 0.00032 21.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain NIF PF03031.16 NM_153088.2_2 - 4.6e-51 172.5 0.0 6.1e-51 172.2 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase POM121 PF15229.4 NM_148932.2_3 - 1.1e-108 362.3 23.4 1.1e-108 362.3 23.4 4.1 3 1 2 5 5 5 1 POM121 family BNIP2 PF12496.6 NM_181348.4_2 - 1.5e-39 135.4 2.8 1.5e-39 135.4 2.8 7.0 7 2 1 8 8 8 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 NM_181348.4_2 - 1.4e-32 112.5 0.2 2.3e-32 111.9 0.2 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DHHA2 PF02833.12 NM_181348.4_2 - 1e-13 51.5 0.1 1.8e-13 50.7 0.1 1.4 1 0 0 1 1 1 1 DHHA2 domain CRAL_TRIO PF00650.18 NM_181348.4_2 - 5.3e-07 29.4 0.3 9.8e-07 28.5 0.3 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain HLH PF00010.24 NM_013685.2_3 - 2e-11 43.6 1.0 5.4e-11 42.2 1.0 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 NM_013685.2_3 - 3 5.9 9.6 5.2 5.1 9.6 1.2 1 0 0 1 1 1 0 CDC45-like protein zf-H2C2_2 PF13465.4 NM_001142411.2_1 - 0.13 12.7 0.1 0.13 12.7 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zf-H2C2_2 PF13465.4 NM_001142411.2_2 - 1.5e-101 328.5 130.1 3.9e-09 36.4 1.4 16.8 18 0 0 18 18 18 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001142411.2_2 - 1.1e-46 154.5 127.1 0.00012 22.2 0.8 16.0 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001142411.2_2 - 6.8e-37 122.8 118.8 0.00016 22.1 4.1 15.7 15 0 0 15 15 15 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001142411.2_2 - 4.8e-32 109.2 108.6 3.6e-05 23.4 1.9 15.0 14 0 0 14 14 14 14 C2H2-type zinc finger KRAB PF01352.25 NM_001142411.2_2 - 1.6e-22 78.7 0.1 2.9e-22 77.9 0.1 1.4 1 0 0 1 1 1 1 KRAB box DUF3268 PF11672.6 NM_001142411.2_2 - 0.024 14.8 54.1 0.44 10.7 3.9 7.3 4 1 1 7 7 7 0 zinc-finger-containing domain HA2 PF04408.21 NM_145742.2_2 - 1.3e-19 70.3 0.0 2.8e-19 69.3 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 NM_145742.2_2 - 2.6e-13 50.2 0.1 5.3e-13 49.2 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.14 NM_145742.2_2 - 1.1e-06 28.6 0.1 9.7e-06 25.5 0.0 2.3 1 1 2 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold ABC_tran PF00005.25 NM_145742.2_2 - 0.0012 19.2 0.1 0.034 14.5 0.1 2.4 1 1 0 2 2 2 1 ABC transporter AAA_22 PF13401.4 NM_145742.2_2 - 0.0024 18.0 0.1 0.0086 16.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain DEAD PF00270.27 NM_145742.2_2 - 0.01 15.5 0.9 0.05 13.2 0.3 2.3 2 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_30 PF13604.4 NM_145742.2_2 - 0.024 14.2 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.4 NM_145742.2_2 - 0.086 13.0 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain V1R PF03402.12 NM_011683.2_2 - 5.4e-135 449.0 29.9 7.8e-135 448.5 29.9 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R RIIa PF02197.15 NM_011683.2_2 - 0.094 12.3 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit Sulfate_transp PF00916.18 NM_177615.3_1 - 1.3e-100 336.7 15.2 1.6e-100 336.4 15.2 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 NM_177615.3_1 - 3.1e-17 62.1 0.0 5.3e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 STAS domain zf-H2C2_2 PF13465.4 NM_011769.4_3 - 5.5e-58 190.8 102.5 4.7e-08 33.0 2.7 12.5 12 0 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_011769.4_3 - 3.4e-44 146.8 106.3 6.7e-06 26.1 2.1 11.9 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_011769.4_3 - 1.3e-29 100.2 95.9 0.0012 19.4 1.0 12.2 11 0 0 11 11 11 11 C2H2-type zinc finger KRAB PF01352.25 NM_011769.4_3 - 1.8e-24 85.0 0.3 3.3e-24 84.2 0.3 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_011769.4_3 - 1.6e-14 53.3 76.7 0.08 12.8 2.2 11.9 11 0 0 11 11 11 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_011769.4_3 - 5.4e-08 32.7 57.2 0.031 14.3 2.0 8.3 5 1 3 8 8 8 6 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_011769.4_3 - 0.0068 17.0 45.3 1.4 9.6 3.7 6.8 3 1 3 6 6 6 4 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_011769.4_3 - 0.013 15.6 0.8 0.013 15.6 0.8 12.2 13 0 0 13 13 13 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_011769.4_3 - 0.019 14.6 0.5 0.019 14.6 0.5 10.5 11 0 0 11 11 11 0 zinc-finger C2H2-type XPA_N PF01286.16 NM_011769.4_3 - 0.14 12.1 58.1 0.47 10.4 0.2 11.0 11 0 0 11 11 11 0 XPA protein N-terminal LRR_6 PF13516.4 NM_198019.2_2 - 1.8e-12 46.1 9.7 0.016 15.1 0.0 5.8 5 0 0 5 5 5 4 Leucine Rich repeat LRR_1 PF00560.31 NM_198019.2_2 - 0.007 16.5 0.1 81 4.2 0.1 5.2 5 0 0 5 5 5 0 Leucine Rich Repeat Cortex-I_coil PF09304.8 NM_198019.2_2 - 0.0093 16.0 3.6 0.026 14.6 3.6 1.8 1 0 0 1 1 1 1 Cortexillin I, coiled coil LRR_4 PF12799.5 NM_198019.2_2 - 0.3 11.4 3.9 18 5.8 0.1 3.8 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) NUDIX PF00293.26 NM_001291046.1_3 - 3.7e-16 59.2 0.2 5.2e-16 58.7 0.2 1.2 1 0 0 1 1 1 1 NUDIX domain Motile_Sperm PF00635.24 NM_019806.5_3 - 7.8e-31 106.0 0.1 1.2e-30 105.4 0.1 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ZapB PF06005.10 NM_019806.5_3 - 0.063 13.6 0.8 0.11 12.9 0.8 1.2 1 0 0 1 1 1 0 Cell division protein ZapB Cupin_8 PF13621.4 NM_178659.6_3 - 1.9e-18 67.1 0.2 2.9e-18 66.5 0.2 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.20 NM_178659.6_3 - 9.6e-18 64.6 0.3 1.8e-17 63.7 0.3 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.10 NM_178659.6_3 - 0.11 11.8 0.1 0.17 11.2 0.1 1.1 1 0 0 1 1 1 0 Cupin superfamily protein S1 PF00575.21 NM_011053.2_3 - 5.7e-64 212.3 9.0 1.5e-12 47.5 0.0 13.2 13 0 0 13 13 13 8 S1 RNA binding domain Suf PF05843.12 NM_011053.2_3 - 1.4e-09 38.2 0.7 1.4e-09 38.2 0.7 4.0 2 1 2 4 4 4 3 Suppressor of forked protein (Suf) TPR_14 PF13428.4 NM_011053.2_3 - 1e-07 32.0 0.1 0.36 11.6 0.0 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_011053.2_3 - 3.9e-07 30.4 0.1 0.32 11.4 0.0 3.8 3 1 0 3 3 3 3 Tetratricopeptide repeat NRDE-2 PF08424.8 NM_011053.2_3 - 3.9e-05 22.8 3.7 0.46 9.4 0.0 3.8 1 1 2 3 3 3 3 NRDE-2, necessary for RNA interference TPR_15 PF13429.4 NM_011053.2_3 - 0.0016 17.6 5.4 0.13 11.3 0.1 3.2 1 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_011053.2_3 - 0.002 18.1 0.9 2.7 8.3 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_011053.2_3 - 0.002 18.2 0.7 0.56 10.4 0.2 4.0 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.4 NM_011053.2_3 - 0.0074 16.1 0.1 0.17 11.9 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_011053.2_3 - 0.011 16.1 2.9 0.48 11.0 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.4 NM_011053.2_3 - 0.013 16.0 0.1 31 5.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_011053.2_3 - 0.018 15.0 4.0 1.7 8.8 0.2 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 NM_011053.2_3 - 0.092 12.5 0.5 0.61 9.9 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3915 PF13054.4 NM_029935.5_1 - 1.1 9.1 7.1 1.9 8.3 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 NM_029935.5_2 - 0.053 13.4 8.4 0.11 12.4 8.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 NM_029935.5_2 - 0.15 10.2 14.3 0.22 9.6 14.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family Sulfotransfer_1 PF00685.25 NM_029935.5_3 - 1.6e-14 53.9 0.0 2e-13 50.3 0.0 2.1 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_029935.5_3 - 1.3e-12 48.4 0.1 3.6e-12 47.0 0.1 1.8 1 1 0 1 1 1 1 Sulfotransferase family DUF3915 PF13054.4 NM_029935.5_3 - 0.17 11.7 8.1 0.33 10.8 8.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Rap_GAP PF02145.13 NM_001164482.1_2 - 4.7e-61 205.5 0.0 6.4e-61 205.0 0.0 1.2 1 0 0 1 1 1 1 Rap/ran-GAP PDZ PF00595.22 NM_001164482.1_2 - 1e-08 35.3 0.0 1.7e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) CREPT PF16566.3 NM_001164482.1_2 - 0.11 12.5 0.3 0.28 11.2 0.1 1.7 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour ZapB PF06005.10 NM_001164482.1_2 - 0.14 12.5 5.1 0.26 11.6 5.1 1.4 1 0 0 1 1 1 0 Cell division protein ZapB ALIX_LYPXL_bnd PF13949.4 NM_001164482.1_2 - 0.16 11.1 3.5 5.8 6.0 0.1 2.2 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV Lzipper-MIP1 PF14389.4 NM_001164482.1_2 - 0.28 11.3 4.7 0.8 9.9 4.0 2.1 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 PI3K_P85_iSH2 PF16454.3 NM_001164482.1_2 - 0.59 9.6 2.4 0.8 9.1 0.9 1.8 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain IncA PF04156.12 NM_001164482.1_2 - 1.4 8.6 7.7 2.8 7.6 7.7 1.4 1 1 0 1 1 1 0 IncA protein FF PF01846.17 NM_183289.3_3 - 7.5e-21 73.9 9.6 4.2e-11 42.7 0.6 2.4 2 0 0 2 2 2 2 FF domain WW PF00397.24 NM_183289.3_3 - 1.5e-05 24.7 0.1 1.5e-05 24.7 0.1 2.1 2 0 0 2 2 2 1 WW domain TEX33 PF15400.4 NM_028522.1_2 - 1.5e-69 232.8 0.9 2.8e-69 231.9 0.9 1.5 1 0 0 1 1 1 1 Testis-expressed sequence 33 protein family TIMP PF00965.15 NM_011593.2_3 - 5.4e-60 202.2 1.6 6.5e-60 201.9 1.6 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase DUF3906 PF13046.4 NM_011593.2_3 - 0.1 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) Ion_trans PF00520.29 NM_001044308.2_1 - 2.6e-255 842.2 78.4 9.9e-80 267.2 12.4 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.10 NM_001044308.2_1 - 1.1e-14 53.9 83.7 3e-08 32.6 3.4 9.5 6 3 3 9 9 9 6 Polycystin cation channel DUF788 PF05620.9 NM_001044308.2_1 - 1.2 8.9 7.3 3.2 7.5 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF788) Sec7 PF01369.18 NM_001112700.1_1 - 1.3e-68 230.2 0.1 1.9e-68 229.7 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 NM_001112700.1_1 - 2.5e-29 101.7 0.1 4.3e-29 101.0 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_001112700.1_1 - 9.9e-05 22.6 0.0 0.00019 21.6 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain CEP170_C PF15308.4 NM_001112700.1_1 - 0.015 13.7 0.2 0.021 13.3 0.2 1.1 1 0 0 1 1 1 0 CEP170 C-terminus PH_8 PF15409.4 NM_001112700.1_1 - 0.019 15.1 0.0 0.049 13.8 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain WEMBL PF05701.9 NM_001112700.1_1 - 0.023 13.2 3.9 0.032 12.7 3.9 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light DUF342 PF03961.11 NM_001112700.1_1 - 0.046 12.2 2.2 0.063 11.8 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) PH_3 PF14593.4 NM_001112700.1_1 - 0.047 13.7 0.1 0.13 12.3 0.1 1.7 1 1 0 1 1 1 0 PH domain FlxA PF14282.4 NM_001112700.1_1 - 0.1 12.5 2.1 0.2 11.5 2.1 1.4 1 0 0 1 1 1 0 FlxA-like protein Spc7 PF08317.9 NM_001112700.1_1 - 0.11 11.2 2.2 0.2 10.3 2.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein BBS2_C PF14782.4 NM_001112700.1_1 - 0.3 9.7 3.0 2.7 6.5 2.5 2.0 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal APG6 PF04111.10 NM_001112700.1_1 - 0.46 9.7 5.5 0.48 9.6 3.8 1.7 2 0 0 2 2 2 0 Autophagy protein Apg6 DUF812 PF05667.9 NM_001112700.1_1 - 0.48 9.1 5.9 0.72 8.5 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) GPS2_interact PF15784.3 NM_001112700.1_1 - 1.2 9.8 7.9 0.32 11.6 3.8 2.1 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain Lectin_C PF00059.19 NM_001289706.1_1 - 5.5e-11 43.0 0.3 1.1e-10 42.0 0.3 1.5 1 0 0 1 1 1 1 Lectin C-type domain Epimerase PF01370.19 NM_031201.1_1 - 1.6e-57 194.6 0.0 2.2e-57 194.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 NM_031201.1_1 - 4e-14 52.6 0.2 1e-13 51.3 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.15 NM_031201.1_1 - 1.3e-07 30.9 0.1 2.5e-07 30.0 0.1 1.4 2 0 0 2 2 2 1 RmlD substrate binding domain 3Beta_HSD PF01073.17 NM_031201.1_1 - 0.0007 18.5 0.1 0.016 14.1 0.0 2.2 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.13 NM_031201.1_1 - 0.0017 17.4 1.7 0.012 14.6 0.0 2.5 2 1 1 3 3 3 1 Polysaccharide biosynthesis protein NICE-3 PF07406.9 NM_031201.1_1 - 0.0072 16.2 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 NICE-3 protein Ric8 PF10165.7 NM_183172.2_1 - 1.7e-125 419.5 4.9 2.1e-125 419.2 4.9 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn ApoL PF05461.9 NM_001134802.1_2 - 1.3e-128 428.6 20.5 2.6e-117 391.6 10.8 2.0 1 1 1 2 2 2 2 Apolipoprotein L DUF677 PF05055.10 NM_001134802.1_2 - 0.015 14.1 0.6 0.021 13.6 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF677) MotA_ExbB PF01618.14 NM_001134802.1_2 - 0.29 10.8 2.5 1 9.1 2.5 2.0 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family Keratin_B2_2 PF13885.4 NM_001037822.1_1 - 0.00014 21.6 82.0 0.00014 21.6 82.0 7.4 1 1 4 5 5 5 3 Keratin, high sulfur B2 protein UCH PF00443.27 NM_130879.2_3 - 6.9e-41 140.3 1.4 1.1e-40 139.6 1.4 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_130879.2_3 - 1.3e-21 77.4 0.3 2.9e-21 76.3 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.10 NM_130879.2_3 - 5.9e-08 33.1 0.3 0.0032 17.9 0.0 3.8 3 1 0 3 3 3 2 DUSP domain ubiquitin PF00240.21 NM_130879.2_3 - 0.00052 19.5 0.0 0.0012 18.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Shisa PF13908.4 NM_172737.4_2 - 1.7e-22 80.4 8.3 1.8e-21 77.2 8.3 2.4 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator Lipocalin_2 PF08212.10 NM_007470.4_2 - 1e-24 87.0 0.0 1.4e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Lipocalin-like domain Lipocalin PF00061.21 NM_007470.4_2 - 5.6e-22 78.4 0.0 7.3e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 NM_007470.4_2 - 0.0012 18.6 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 Triabin Ets PF00178.20 NM_001083318.2_3 - 6.8e-33 112.9 2.6 1.2e-32 112.1 2.6 1.4 1 0 0 1 1 1 1 Ets-domain Sulfate_transp PF00916.18 NM_178743.3_3 - 8.3e-95 317.6 14.3 1.1e-94 317.2 14.3 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 NM_178743.3_3 - 7.4e-12 44.8 0.0 1.4e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 STAS domain Na_H_antiport_2 PF13726.4 NM_178743.3_3 - 3.7 7.6 6.2 0.57 10.2 1.5 2.1 2 0 0 2 2 2 0 Na+-H+ antiporter family TruB_C PF09142.9 NM_001252588.1_2 - 0.64 9.7 2.6 12 5.6 0.2 2.5 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal Tetraspannin PF00335.18 NM_001252588.1_3 - 1.6e-51 174.9 15.2 2.1e-51 174.6 15.2 1.1 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.13 NM_001252588.1_3 - 0.29 11.1 11.7 0.21 11.5 7.4 2.4 1 1 1 2 2 2 0 CD20-like family BTB PF00651.29 NM_029773.2_3 - 1.1e-31 109.2 0.9 1.7e-31 108.5 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain MATH PF00917.24 NM_029773.2_3 - 1.8e-05 24.7 0.0 3.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 MATH domain VPS9 PF02204.16 NM_001199059.1_3 - 3.4e-29 101.0 0.0 7.7e-29 99.8 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain zf-A20 PF01754.14 NM_001199059.1_3 - 4.8e-12 45.5 6.8 1.6e-11 43.8 6.8 2.0 1 0 0 1 1 1 1 A20-like zinc finger HEAT PF02985.20 NM_001034085.2_2 - 1.5e-47 155.3 27.4 0.00033 20.5 0.0 13.9 15 0 0 15 15 15 12 HEAT repeat HEAT_2 PF13646.4 NM_001034085.2_2 - 2.1e-41 140.1 11.3 1e-13 51.3 0.0 7.7 3 1 4 8 8 8 7 HEAT repeats Vac14_Fab1_bd PF12755.5 NM_001034085.2_2 - 1e-13 51.5 1.9 0.028 14.9 0.0 7.7 4 2 5 9 9 9 5 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.4 NM_001034085.2_2 - 8.9e-11 41.9 13.2 0.0039 17.5 0.2 7.7 9 2 2 11 11 11 3 HEAT-like repeat Cnd1 PF12717.5 NM_001034085.2_2 - 3.1e-10 40.2 7.0 0.0005 20.0 0.2 4.3 2 2 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.18 NM_001034085.2_2 - 1.8e-09 36.6 5.2 0.0024 16.4 0.0 3.3 1 1 2 3 3 3 3 Adaptin N terminal region CLASP_N PF12348.6 NM_001034085.2_2 - 1.1e-05 24.9 2.9 0.0019 17.7 0.1 4.6 2 2 3 5 5 5 1 CLASP N terminal TAF6_C PF07571.11 NM_001034085.2_2 - 0.0003 21.0 0.4 3.3 8.0 0.0 4.2 4 1 1 5 5 5 2 TAF6 C-terminal HEAT repeat domain Sugar_tr PF00083.22 NM_031197.2_1 - 5.4e-163 542.9 18.1 6.5e-163 542.6 18.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 NM_031197.2_1 - 9.2e-23 80.6 29.9 7.8e-21 74.2 24.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_3 PF16080.3 NM_031197.2_1 - 1.3 8.7 8.5 0.34 10.6 0.6 2.9 2 0 0 2 2 2 0 Bacteriophage holin family HP1 DUF2054 PF10218.7 NM_001081236.1_2 - 1.2e-43 148.2 19.1 1.2e-43 148.2 19.1 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2054) Cid2 PF09774.7 NM_001159421.1_2 - 2.5e-09 37.6 5.4 3.2e-08 34.0 5.2 2.0 1 1 0 1 1 1 1 Caffeine-induced death protein 2 Feld-I_B PF09252.8 NM_001281508.1_2 - 2.9e-28 97.5 0.0 4.1e-28 97.0 0.0 1.2 1 0 0 1 1 1 1 Allergen Fel d I-B chain IL8 PF00048.18 NM_009141.3_2 - 6.3e-12 45.3 1.6 1.1e-11 44.5 1.6 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Pkinase PF00069.23 NM_001285806.1_3 - 3.2e-68 229.8 0.0 5e-68 229.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001285806.1_3 - 4.7e-26 91.5 0.0 6.6e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 NM_001285806.1_3 - 5.3e-13 49.1 5.7 1.6e-12 47.6 5.7 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain PH PF00169.27 NM_001285806.1_3 - 6.8e-10 39.3 0.2 1.2e-09 38.4 0.2 1.4 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.4 NM_001285806.1_3 - 0.046 12.9 0.0 0.068 12.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like MCD PF05292.9 NM_019966.2_1 - 1.6e-117 392.4 0.0 2e-117 392.1 0.0 1.1 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase (MCD) PET PF06297.12 NM_144799.2_3 - 7.2e-36 122.2 0.1 1.2e-35 121.5 0.1 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 NM_144799.2_3 - 1.3e-18 66.8 13.1 1.6e-10 40.9 2.7 3.5 4 1 0 4 4 4 2 LIM domain zf-C2H2 PF00096.24 NM_001037916.3_1 - 0.026 14.9 0.1 0.056 13.8 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type IncA PF04156.12 NM_001037916.3_1 - 0.89 9.2 19.3 0.034 13.8 5.7 3.1 2 2 1 3 3 3 0 IncA protein Troponin PF00992.18 NM_001037916.3_1 - 5.4 7.2 10.1 0.44 10.7 1.1 2.2 2 0 0 2 2 2 0 Troponin Guanylate_kin PF00625.19 NM_007862.3_2 - 7.9e-66 221.1 1.3 1.4e-65 220.3 1.3 1.4 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 NM_007862.3_2 - 4.2e-61 203.1 8.0 2.1e-19 69.5 0.1 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) MAGUK_N_PEST PF10608.7 NM_007862.3_2 - 8.4e-55 184.2 8.7 8.4e-55 184.2 8.7 1.8 2 0 0 2 2 2 1 Polyubiquitination (PEST) N-terminal domain of MAGUK L27_1 PF09058.8 NM_007862.3_2 - 1.4e-29 101.8 4.3 3.4e-29 100.6 4.3 1.7 1 0 0 1 1 1 1 L27_1 PDZ_assoc PF10600.7 NM_007862.3_2 - 2.1e-24 86.0 3.3 8e-24 84.1 3.3 2.1 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 NM_007862.3_2 - 4.6e-16 58.8 0.5 0.00034 20.8 0.1 3.6 3 0 0 3 3 3 3 PDZ domain SH3_1 PF00018.26 NM_007862.3_2 - 8.3e-08 31.6 0.1 1.9e-07 30.4 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_007862.3_2 - 1.2e-07 31.2 0.0 2.7e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_007862.3_2 - 0.014 15.1 0.0 0.032 13.9 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Med15 PF09606.8 NM_001285884.1_2 - 1.3e-158 530.0 130.6 1.7e-158 529.6 130.6 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal YjgP_YjgQ PF03739.12 NM_001285884.1_2 - 0.17 10.5 4.1 0.3 9.8 4.1 1.4 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Med15 PF09606.8 NM_001285884.1_3 - 8.8e-15 54.3 0.1 8.8e-15 54.3 0.1 1.4 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal DFF-C PF09033.8 NM_001025296.2_2 - 2.2e-70 235.7 10.3 3.6e-70 235.0 10.3 1.3 1 0 0 1 1 1 1 DNA Fragmentation factor 45kDa, C terminal domain CIDE-N PF02017.13 NM_001025296.2_2 - 2.4e-25 88.2 0.1 6.1e-25 86.9 0.0 1.7 2 0 0 2 2 2 1 CIDE-N domain MITF_TFEB_C_3_N PF15951.3 NM_178657.5_2 - 0.073 13.6 0.0 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 MITF/TFEB/TFEC/TFE3 N-terminus LRR_4 PF12799.5 NM_178657.5_2 - 3.6 8.0 20.7 4.3 7.7 0.2 5.1 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) DC_STAMP PF07782.11 NM_029422.4_1 - 4.3e-55 186.4 0.9 1.1e-54 185.1 0.9 1.8 1 0 0 1 1 1 1 DC-STAMP-like protein Ammonium_transp PF00909.19 NM_011270.3_3 - 1.1e-47 162.5 26.9 1.5e-47 162.1 26.9 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family MIP PF00230.18 NM_001109045.1_1 - 1e-48 165.9 12.1 1.3e-48 165.5 12.1 1.1 1 0 0 1 1 1 1 Major intrinsic protein fn3 PF00041.19 NM_028004.2_2 - 0 6270.3 325.1 4.6e-18 65.2 0.0 133.7 132 0 0 132 132 132 132 Fibronectin type III domain I-set PF07679.14 NM_028004.2_2 - 0 5060.9 195.5 6e-24 83.8 0.0 118.0 115 0 0 115 115 115 111 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_028004.2_2 - 0 2963.6 56.9 5.8e-15 55.5 0.4 111.8 110 0 0 110 110 110 107 Immunoglobulin domain ig PF00047.23 NM_028004.2_2 - 0 1423.0 145.2 6.5e-11 42.1 0.9 105.1 105 0 0 105 105 105 78 Immunoglobulin domain Ig_2 PF13895.4 NM_028004.2_2 - 0 1338.7 67.9 4.4e-09 36.4 0.2 102.5 103 0 0 103 103 102 74 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 NM_028004.2_2 - 6.7e-160 520.1 230.6 0.0031 17.9 0.0 108.2 117 4 0 117 117 106 28 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 NM_028004.2_2 - 1.8e-114 374.0 0.0 0.0032 17.5 0.0 71.5 88 0 0 88 88 76 13 Fibronectin type III domain V-set PF07686.15 NM_028004.2_2 - 5.3e-98 322.5 139.5 0.014 15.5 0.0 85.3 88 16 0 88 88 85 16 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_028004.2_2 - 1.4e-66 220.4 87.8 0.13 12.2 0.0 58.4 69 1 1 70 70 63 11 CD80-like C2-set immunoglobulin domain Pkinase PF00069.23 NM_028004.2_2 - 9.4e-57 192.2 0.3 2.3e-56 191.0 0.3 1.7 1 0 0 1 1 1 1 Protein kinase domain fn3_4 PF16794.3 NM_028004.2_2 - 1.8e-53 178.6 0.0 0.63 9.8 0.0 46.4 54 0 0 54 54 48 4 Fibronectin-III type domain Titin_Z PF09042.9 NM_028004.2_2 - 2e-51 171.5 87.2 6.5e-10 38.7 9.6 6.8 6 0 0 6 6 6 6 Titin Z Receptor_2B4 PF11465.6 NM_028004.2_2 - 1.5e-47 160.1 74.4 0.43 10.7 0.0 56.7 69 1 1 70 70 60 4 Natural killer cell receptor 2B4 Tissue_fac PF01108.15 NM_028004.2_2 - 3.2e-35 120.0 96.7 0.17 11.6 0.0 52.3 69 0 0 69 69 56 4 Tissue factor DUF2369 PF10179.7 NM_028004.2_2 - 1.5e-28 98.9 14.6 1.3 9.4 0.0 31.5 36 0 0 36 36 26 2 Uncharacterised conserved protein (DUF2369) Pkinase_Tyr PF07714.15 NM_028004.2_2 - 2.2e-27 95.8 0.2 4e-27 95.0 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Izumo-Ig PF16706.3 NM_028004.2_2 - 1.8e-11 43.8 82.1 1 9.3 0.0 33.3 42 0 0 42 42 32 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 NM_028004.2_2 - 8.1e-10 38.9 71.9 1.1 9.5 0.0 30.5 36 0 0 36 36 28 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.13 NM_028004.2_2 - 2.9e-08 33.9 66.7 6.6 7.1 0.1 27.6 32 0 0 32 32 26 0 Immunoglobulin C1-set domain Y_Y_Y PF07495.11 NM_028004.2_2 - 5.2e-08 32.6 78.8 8.8 6.2 0.0 39.7 52 0 0 52 52 43 0 Y_Y_Y domain Membrane_bind PF14564.4 NM_028004.2_2 - 0.11 12.8 0.3 10 6.5 0.1 4.7 3 0 0 3 3 2 0 Membrane binding Kelch_1 PF01344.23 NM_028004.2_2 - 0.2 11.1 0.8 0.86 9.1 0.8 2.2 1 0 0 1 1 1 0 Kelch motif PKD_3 PF16820.3 NM_028004.2_2 - 2 8.1 33.1 8.9 6.0 0.1 15.3 21 0 0 21 21 18 0 PKD-like domain DUF11 PF01345.16 NM_028004.2_2 - 2.2 8.5 110.8 1.2 9.3 0.4 32.4 39 1 0 39 39 27 0 Domain of unknown function DUF11 CBX7_C PF17218.1 NM_028004.2_2 - 3 7.5 16.2 8.5 6.1 0.0 7.4 7 0 0 7 7 6 0 CBX family C-terminal motif zf-Di19 PF05605.10 NM_030743.5_1 - 5.4e-16 58.5 2.3 5.4e-16 58.5 2.3 3.4 4 1 0 4 4 1 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_UBOX PF13445.4 NM_030743.5_1 - 3.1e-08 33.4 11.1 3.1e-08 33.4 11.1 3.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_030743.5_1 - 2.3e-07 30.4 11.4 2.3e-07 30.4 11.4 4.1 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_030743.5_1 - 3.9e-07 29.7 9.9 3.9e-07 29.7 9.9 4.2 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_030743.5_1 - 8e-07 29.0 14.0 8e-07 29.0 14.0 3.2 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 NM_030743.5_1 - 1.2e-06 28.1 13.1 1.2e-06 28.1 13.1 3.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_030743.5_1 - 1.9e-06 27.9 11.5 1.9e-06 27.9 11.5 4.2 4 1 0 4 4 2 1 Ring finger domain zf-RING_5 PF14634.4 NM_030743.5_1 - 7.5e-06 25.7 11.2 7.5e-06 25.7 11.2 5.5 6 0 0 6 6 4 1 zinc-RING finger domain zf-RING_6 PF14835.4 NM_030743.5_1 - 0.00036 20.2 3.4 0.00036 20.2 3.4 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 NM_030743.5_1 - 0.011 15.4 11.1 0.011 15.4 11.1 4.7 6 0 0 6 6 5 0 Prokaryotic RING finger family 4 U-box PF04564.13 NM_030743.5_1 - 0.014 15.4 0.0 0.03 14.4 0.0 1.5 1 0 0 1 1 1 0 U-box domain zf-RING_11 PF17123.3 NM_030743.5_1 - 0.074 12.7 4.4 0.42 10.2 4.4 2.5 1 0 0 1 1 1 0 RING-like zinc finger zf-C2H2 PF00096.24 NM_030743.5_1 - 0.19 12.1 11.7 17 5.9 0.9 6.0 5 0 0 5 5 5 0 Zinc finger, C2H2 type Rtf2 PF04641.10 NM_030743.5_1 - 1.8 7.7 7.5 2 7.5 6.5 1.6 1 1 0 1 1 1 0 Rtf2 RING-finger zf-H2C2_2 PF13465.4 NM_030743.5_1 - 3.5 8.1 14.8 11 6.6 0.3 4.9 4 0 0 4 4 4 0 Zinc-finger double domain PAP_assoc PF03828.17 NM_133905.2_3 - 5.9e-15 55.1 0.0 1.4e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.21 NM_133905.2_3 - 0.014 15.5 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain Cor1 PF04803.10 NM_133905.2_3 - 2.5 8.2 6.5 16 5.6 0.3 2.3 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region CHZ PF09649.8 NM_172746.3_1 - 1.2e-09 37.4 0.5 2.9e-09 36.1 0.5 1.8 1 0 0 1 1 1 1 Histone chaperone domain CHZ zf-H2C2_2 PF13465.4 NM_009560.2_1 - 1.5e-116 376.0 158.7 2.9e-07 30.5 1.4 21.7 22 0 0 22 22 22 20 Zinc-finger double domain zf-C2H2 PF00096.24 NM_009560.2_1 - 1.1e-76 249.1 165.9 4e-06 26.9 0.8 22.4 22 0 0 22 22 22 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_009560.2_1 - 3.4e-44 145.5 158.5 0.0036 17.9 1.1 21.3 22 0 0 22 22 20 19 C2H2-type zinc finger KRAB PF01352.25 NM_009560.2_1 - 7.5e-22 76.6 0.5 1.4e-21 75.8 0.5 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_009560.2_1 - 9.1e-22 76.4 126.9 0.00054 19.7 0.2 20.9 21 0 0 21 21 21 14 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_009560.2_1 - 7.2e-18 64.3 100.3 0.012 15.6 2.0 15.5 8 5 8 17 17 17 12 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_009560.2_1 - 2.2e-08 34.1 104.3 0.11 12.7 0.0 18.8 20 0 0 20 20 18 8 Zinc-finger double-stranded RNA-binding BolA PF01722.16 NM_009560.2_1 - 0.0028 17.8 20.6 9.3 6.5 0.4 7.4 4 2 2 6 6 6 1 BolA-like protein zinc_ribbon_15 PF17032.3 NM_009560.2_1 - 0.04 14.5 77.8 1.1 10.0 2.7 10.4 2 1 4 9 9 9 0 zinc-ribbon family MRP-S23 PF10484.7 NM_009560.2_1 - 0.12 12.5 0.0 46 4.1 0.0 4.3 4 2 2 6 6 6 0 Mitochondrial ribosomal protein S23 HypA PF01155.17 NM_009560.2_1 - 0.51 10.2 71.0 3 7.8 4.0 10.3 2 1 8 10 10 10 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA adh_short PF00106.23 NM_080436.3_2 - 2.4e-40 138.0 0.0 3.4e-40 137.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_080436.3_2 - 2.4e-25 89.3 0.0 3.5e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.8 NM_080436.3_2 - 0.0028 16.9 0.0 0.0052 16.1 0.0 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.8 NM_080436.3_2 - 0.005 16.6 0.0 0.0083 15.9 0.0 1.2 1 0 0 1 1 1 1 KR domain WD40 PF00400.30 NM_001253844.1_2 - 9.8e-31 105.2 11.0 1.8e-07 31.6 0.0 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat Prp19 PF08606.9 NM_001253844.1_2 - 3.2e-22 78.1 3.2 6.7e-22 77.1 3.2 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.5 NM_001253844.1_2 - 2.1e-11 43.8 0.0 0.015 15.5 0.0 4.3 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_001253844.1_2 - 0.005 16.6 0.0 3.3 7.4 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.14 NM_001253844.1_2 - 0.0059 15.0 0.0 2.1 6.6 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.3 NM_001253844.1_2 - 0.0092 14.9 0.2 6 5.6 0.0 3.1 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 NM_001253844.1_2 - 0.012 14.1 0.9 0.58 8.6 0.2 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 NPC1_N PF16414.3 NM_008720.2_3 - 1.6e-80 270.0 8.1 1.6e-80 270.0 8.1 1.9 2 0 0 2 2 2 1 Niemann-Pick C1 N terminus Patched PF02460.16 NM_008720.2_3 - 1.2e-78 265.0 30.0 2.7e-48 164.6 2.8 2.7 3 0 0 3 3 3 2 Patched family Sterol-sensing PF12349.6 NM_008720.2_3 - 3.3e-55 186.0 5.5 3.3e-55 186.0 5.5 2.9 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.13 NM_008720.2_3 - 1.6e-05 23.9 2.6 1.6e-05 23.9 2.6 2.4 2 1 0 2 2 2 1 MMPL family ACR_tran PF00873.17 NM_008720.2_3 - 0.00021 19.0 4.8 0.00021 19.0 4.8 2.0 2 0 0 2 2 2 1 AcrB/AcrD/AcrF family CCDC92 PF14916.4 NM_144819.2_3 - 1.3e-21 75.9 3.7 1.3e-21 75.9 3.7 2.4 2 0 0 2 2 2 1 Coiled-coil domain of unknown function Exonuc_VII_L PF02601.13 NM_144819.2_3 - 0.076 12.4 6.6 0.11 11.9 6.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATG16 PF08614.9 NM_144819.2_3 - 0.17 11.9 21.6 2.2 8.3 15.7 3.1 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) ADIP PF11559.6 NM_144819.2_3 - 0.96 9.4 17.1 1 9.3 14.4 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding APG6 PF04111.10 NM_144819.2_3 - 1.5 8.0 16.8 2.2 7.4 16.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Fez1 PF06818.13 NM_144819.2_3 - 2 8.7 15.7 2.2 8.5 13.8 1.8 1 1 0 1 1 1 0 Fez1 Atg14 PF10186.7 NM_144819.2_3 - 2.6 6.9 16.9 2.3 7.1 15.0 1.7 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 IncA PF04156.12 NM_144819.2_3 - 3.5 7.3 22.5 8.3 6.0 17.7 2.2 1 1 1 2 2 2 0 IncA protein Reo_sigmaC PF04582.10 NM_144819.2_3 - 5.2 6.2 5.3 7.1 5.8 3.6 1.8 1 1 1 2 2 2 0 Reovirus sigma C capsid protein SPATA19 PF15212.4 NM_029299.3_3 - 4.5e-75 250.0 9.4 5.4e-75 249.7 9.4 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated protein 19, mitochondrial AAA_12 PF13087.4 NM_001163441.1_1 - 1.9e-46 158.1 0.0 3e-46 157.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.4 NM_001163441.1_1 - 2e-23 83.3 1.3 2.4e-11 43.8 0.0 2.8 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.4 NM_001163441.1_1 - 6.9e-12 45.4 0.0 1.3e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.4 NM_001163441.1_1 - 1.8e-08 34.7 0.0 3.5e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.13 NM_001163441.1_1 - 2.1e-07 31.0 0.0 5.7e-07 29.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.4 NM_001163441.1_1 - 0.00016 21.8 0.0 0.00046 20.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.12 NM_001163441.1_1 - 0.017 14.8 0.0 0.044 13.5 0.0 1.7 1 0 0 1 1 1 0 Helicase AAA_16 PF13191.4 NM_001163441.1_1 - 0.032 14.5 0.0 0.092 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.18 NM_001163441.1_1 - 0.088 11.7 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.16 NM_001163441.1_1 - 0.092 12.5 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PIF1 PF05970.12 NM_001163441.1_1 - 0.11 11.5 0.0 11 4.9 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA PF00004.27 NM_001163441.1_1 - 0.17 12.2 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ank_4 PF13637.4 NM_133346.2_1 - 1e-18 67.3 3.8 2.6e-05 24.6 0.0 5.3 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 NM_133346.2_1 - 2.6e-16 59.1 3.6 1.5e-06 28.3 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.4 NM_133346.2_1 - 1.4e-14 53.8 3.1 9.9e-07 28.8 0.1 5.0 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_133346.2_1 - 5.3e-14 52.4 1.5 1.6e-06 28.5 0.0 3.7 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_133346.2_1 - 5.7e-12 44.6 2.5 6.8e-06 25.9 0.0 6.0 6 0 0 6 6 6 2 Ankyrin repeat SOCS_box PF07525.14 NM_133346.2_1 - 9.2e-12 45.0 5.0 3e-11 43.3 5.0 1.9 1 0 0 1 1 1 1 SOCS box Tetraspannin PF00335.18 NM_009842.3_2 - 9.2e-50 169.2 13.0 1.3e-49 168.8 13.0 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF4199 PF13858.4 NM_009842.3_2 - 1.1e-05 25.8 1.1 2.1e-05 24.8 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) CD20 PF04103.13 NM_009842.3_2 - 6.2e-05 23.0 7.2 0.00012 22.0 7.0 1.6 1 1 0 1 1 1 1 CD20-like family SUR7 PF06687.10 NM_009842.3_2 - 0.0024 17.4 3.4 0.0047 16.5 3.4 1.4 1 0 0 1 1 1 1 SUR7/PalI family DUF2569 PF10754.7 NM_009842.3_2 - 0.21 11.9 6.6 0.43 10.9 6.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) DUF373 PF04123.11 NM_009842.3_2 - 1.7 7.8 5.1 3.1 7.0 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF308 PF03729.11 NM_009842.3_2 - 2.7 8.3 17.2 0.39 11.0 7.4 2.7 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) Rubi_NSP_C PF12601.6 NM_009842.3_3 - 0.045 13.7 0.3 0.21 11.6 0.2 2.1 2 0 0 2 2 2 0 Rubivirus non-structural protein BTB PF00651.29 NM_001085507.1_3 - 3.1e-25 88.4 0.2 5.7e-25 87.6 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 NM_001085507.1_3 - 8.4e-15 54.2 17.0 0.00023 21.3 1.3 4.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001085507.1_3 - 1.3e-12 47.4 17.5 8e-07 29.1 0.6 5.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001085507.1_3 - 2.4e-09 37.1 20.6 0.0021 18.6 0.3 5.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 NM_001085507.1_3 - 4.7e-06 26.7 9.7 0.015 15.6 0.4 4.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type DUF3342 PF11822.6 NM_001085507.1_3 - 6.1e-05 23.0 0.1 0.00013 22.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2_11 PF16622.3 NM_001085507.1_3 - 7.8e-05 22.2 10.1 0.02 14.5 0.2 4.4 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 NM_001085507.1_3 - 0.0013 18.9 6.4 1 9.6 0.4 3.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-BED PF02892.13 NM_001085507.1_3 - 0.015 15.2 16.7 1.2 9.1 0.8 4.7 2 1 1 3 3 3 0 BED zinc finger zf-C2H2_6 PF13912.4 NM_001085507.1_3 - 0.67 9.8 9.7 3.2 7.7 0.4 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.5 NM_001085507.1_3 - 1.1 9.6 11.2 0.76 10.0 0.1 3.8 2 1 2 4 4 3 0 C2H2 type zinc-finger (2 copies) TAF1_subA PF14929.4 NM_001277957.1_3 - 2.4e-120 402.2 15.7 3.2e-120 401.8 15.7 1.1 1 0 0 1 1 1 1 TAF RNA Polymerase I subunit A Nrf1_DNA-bind PF10491.7 NM_001164230.1_1 - 4e-116 386.0 0.1 5.5e-116 385.5 0.1 1.2 1 0 0 1 1 1 1 NLS-binding and DNA-binding and dimerisation domains of Nrf1 DUF5008 PF16400.3 NM_001164230.1_1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5008) 2OG-FeII_Oxy_3 PF13640.4 NM_028133.2_2 - 9.4e-19 68.0 0.0 1.6e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.4 NM_028133.2_2 - 2.8e-09 37.4 0.0 4.7e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-SAP30 PF13866.4 NM_021788.2_1 - 5.2e-36 122.4 3.7 1.1e-35 121.4 3.7 1.4 1 0 0 1 1 1 1 SAP30 zinc-finger SAP30_Sin3_bdg PF13867.4 NM_021788.2_1 - 2e-22 79.1 0.0 3e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Titin_Z PF09042.9 NM_021788.2_1 - 3.2 7.6 7.6 5.5 6.9 7.6 1.3 1 0 0 1 1 1 0 Titin Z CUE PF02845.14 NM_138667.3_2 - 5.2e-09 35.5 0.2 9e-09 34.7 0.2 1.4 1 0 0 1 1 1 1 CUE domain zf-RanBP PF00641.16 NM_138667.3_2 - 3.7e-05 22.8 1.2 0.00011 21.3 1.2 1.8 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Spc29 PF17082.3 NM_138667.3_2 - 0.0055 16.4 1.3 0.012 15.4 1.3 1.5 1 0 0 1 1 1 1 Spindle Pole Component 29 IncA PF04156.12 NM_138667.3_2 - 0.028 14.1 0.4 0.047 13.3 0.4 1.2 1 0 0 1 1 1 0 IncA protein Mnd1 PF03962.13 NM_138667.3_2 - 0.23 11.2 3.8 0.39 10.4 3.8 1.3 1 0 0 1 1 1 0 Mnd1 family DivIC PF04977.13 NM_138667.3_2 - 1.8 8.2 6.9 1.1 9.0 3.6 2.1 1 1 1 2 2 2 0 Septum formation initiator XhlA PF10779.7 NM_138667.3_2 - 3.4 7.8 4.8 5.9 7.0 4.8 1.3 1 0 0 1 1 1 0 Haemolysin XhlA SlyX PF04102.10 NM_138667.3_2 - 3.6 8.1 5.3 3.1 8.4 3.5 1.8 1 1 0 1 1 1 0 SlyX Reprolysin PF01421.17 NM_001048175.2_3 - 1.2e-67 227.6 1.0 1.2e-67 227.6 1.0 2.2 2 0 0 2 2 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 NM_001048175.2_3 - 3.7e-31 108.1 0.1 7.9e-31 107.0 0.1 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.10 NM_001048175.2_3 - 3.2e-20 72.6 8.8 3.2e-20 72.6 8.8 3.4 3 0 0 3 3 1 1 ADAM cysteine-rich Disintegrin PF00200.21 NM_001048175.2_3 - 3.6e-19 69.2 30.2 3.6e-19 69.2 30.2 4.1 3 0 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.4 NM_001048175.2_3 - 3.6e-18 66.2 0.7 7.5e-18 65.1 0.7 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 NM_001048175.2_3 - 8.1e-17 61.9 0.6 1.7e-16 60.9 0.6 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.4 NM_001048175.2_3 - 1.3e-12 47.9 0.2 2.6e-12 46.9 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_001048175.2_3 - 5.7e-10 39.0 0.1 1.1e-09 38.2 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.6 NM_001048175.2_3 - 0.0054 16.2 0.2 0.011 15.2 0.2 1.4 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase 7tm_1 PF00001.19 NM_001048175.2_3 - 0.017 14.3 0.0 0.039 13.1 0.0 1.5 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) FAM176 PF14851.4 NM_001048175.2_3 - 0.37 10.3 0.0 0.37 10.3 0.0 2.4 2 0 0 2 2 1 0 FAM176 family LSM14 PF12701.5 NM_177727.4_2 - 8.9e-31 105.7 0.0 1.5e-30 104.9 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.8 NM_177727.4_2 - 2.3e-25 89.3 9.4 4.3e-25 88.5 9.4 1.5 1 0 0 1 1 1 1 FDF domain SM-ATX PF14438.4 NM_177727.4_2 - 4.9e-08 32.9 0.0 9.6e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain SH3_9 PF14604.4 NM_001034964.1_2 - 1.6e-37 127.0 1.1 2.2e-14 52.9 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 NM_001034964.1_2 - 2.3e-36 123.0 0.2 3.5e-11 42.4 0.0 3.6 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 NM_001034964.1_2 - 1.2e-29 101.6 0.2 3.6e-12 45.7 0.0 3.7 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 NM_001034964.1_2 - 1.2e-22 79.2 0.7 2.2e-22 78.3 0.7 1.5 1 0 0 1 1 1 1 Sorbin homologous domain HA2 PF04408.21 NM_001286031.1_3 - 6.3e-20 71.3 0.0 1.1e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.14 NM_001286031.1_3 - 6.7e-14 51.8 0.0 1.4e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold zf-RING_2 PF13639.4 NM_153504.3_3 - 2.6e-10 40.2 12.6 7.6e-10 38.8 12.6 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_153504.3_3 - 4.9e-06 26.3 10.2 1.2e-05 25.0 10.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 NM_153504.3_3 - 7.1e-05 22.4 9.3 0.00019 21.1 9.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_153504.3_3 - 0.00013 21.7 9.9 0.00013 21.7 9.9 2.6 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 NM_153504.3_3 - 0.00068 19.6 11.4 0.0024 17.9 11.4 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.4 NM_153504.3_3 - 0.095 12.3 7.6 0.14 11.8 6.2 2.0 1 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.23 NM_153504.3_3 - 0.13 12.0 15.1 0.025 14.3 11.1 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_153504.3_3 - 0.29 10.9 16.2 0.073 12.8 12.2 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 NM_153504.3_3 - 1.3 8.7 9.1 2.7 7.6 9.1 1.6 1 0 0 1 1 1 0 RING-like zinc finger 7tm_1 PF00001.19 NM_001302377.1_1 - 2e-22 79.6 5.8 5e-21 75.0 5.8 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ELP6 PF09807.7 NM_001081381.1_3 - 1.3e-112 375.1 0.3 1.7e-112 374.8 0.3 1.1 1 0 0 1 1 1 1 Elongation complex protein 6 Frataxin_Cyay PF01491.14 NM_008044.2_1 - 1.4e-37 127.9 0.0 2e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Frataxin-like domain S1FA PF04689.11 NM_008044.2_1 - 0.37 10.8 2.8 0.68 10.0 2.8 1.3 1 0 0 1 1 1 0 DNA binding protein S1FA FIBP PF05427.9 NM_021438.4_1 - 1.1e-170 567.7 0.9 1.2e-170 567.5 0.9 1.0 1 0 0 1 1 1 1 Acidic fibroblast growth factor binding (FIBP) RRM_1 PF00076.20 NM_001166636.1_1 - 3.6e-13 49.0 0.0 5.8e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.4 NM_001166636.1_1 - 0.00032 21.1 14.9 0.00032 21.1 14.9 3.5 2 2 2 4 4 3 1 C-terminal duplication domain of Friend of PRMT1 FYTT PF07078.9 NM_001166636.1_1 - 0.00064 19.1 0.1 0.00064 19.1 0.1 2.4 2 0 0 2 2 1 1 Forty-two-three protein DUF2360 PF10152.7 NM_001166636.1_1 - 0.0025 18.1 11.5 0.0034 17.7 11.5 1.2 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein (DUF2360) TFIIA PF03153.11 NM_001166636.1_1 - 0.0046 16.9 30.3 0.0056 16.6 30.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CPSF100_C PF13299.4 NM_001166636.1_1 - 0.0077 16.3 8.9 0.011 15.7 8.9 1.3 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Coilin_N PF15862.3 NM_001166636.1_1 - 0.009 15.7 15.3 0.014 15.1 15.3 1.3 1 0 0 1 1 1 1 Coilin N-terminus Pex14_N PF04695.11 NM_001166636.1_1 - 0.011 16.4 14.8 0.034 14.7 15.2 1.6 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DDHD PF02862.15 NM_001166636.1_1 - 0.012 15.6 11.9 0.016 15.2 11.9 1.2 1 0 0 1 1 1 0 DDHD domain eIF-3_zeta PF05091.10 NM_001166636.1_1 - 0.074 11.9 19.9 0.092 11.6 19.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Borrelia_P83 PF05262.9 NM_001166636.1_1 - 0.13 10.6 13.2 0.15 10.4 13.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SID-1_RNA_chan PF13965.4 NM_001166636.1_1 - 0.16 10.3 2.6 0.17 10.2 2.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NPR3 PF03666.11 NM_001166636.1_1 - 0.2 10.3 16.7 0.25 10.0 16.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_U57 PF05582.10 NM_001166636.1_1 - 0.28 10.3 10.6 0.4 9.8 10.6 1.2 1 0 0 1 1 1 0 YabG peptidase U57 EOS1 PF12326.6 NM_001166636.1_1 - 0.34 10.7 6.1 0.48 10.2 6.1 1.3 1 0 0 1 1 1 0 N-glycosylation protein DUF1510 PF07423.9 NM_001166636.1_1 - 0.47 9.7 21.7 0.66 9.2 21.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF913 PF06025.10 NM_001166636.1_1 - 0.48 9.2 8.0 0.59 8.9 8.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Gti1_Pac2 PF09729.7 NM_001166636.1_1 - 0.97 9.3 16.3 1.5 8.7 16.3 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4407 PF14362.4 NM_001166636.1_1 - 1.2 8.2 15.7 2 7.5 15.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MAJIN PF15077.4 NM_001166636.1_1 - 1.3 8.8 13.6 1.8 8.3 13.6 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein FAM60A PF15396.4 NM_001166636.1_1 - 3 7.6 13.7 4.5 7.1 13.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SpoIIP PF07454.9 NM_001166636.1_1 - 3 7.1 20.2 4.3 6.6 20.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.10 NM_001166636.1_1 - 3.2 7.4 22.9 4.6 6.8 22.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1764 PF08576.8 NM_001166636.1_1 - 3.9 8.2 19.5 8.4 7.2 19.5 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) LMBR1 PF04791.14 NM_001166636.1_1 - 4.4 5.9 4.9 5.1 5.7 4.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein EPL1 PF10513.7 NM_001166636.1_1 - 5.4 7.2 22.7 8.3 6.6 22.7 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF3306 PF11748.6 NM_001166636.1_1 - 7.7 7.3 18.4 16 6.3 18.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DUF2052 PF09747.7 NM_001166636.1_1 - 8.9 6.3 26.5 13 5.7 26.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Apt1 PF10351.7 NM_001166636.1_2 - 4.1 6.0 14.8 5.1 5.7 14.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Glyco_hydro_9 PF00759.17 NM_001166636.1_3 - 0.71 9.1 12.1 1 8.6 12.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 RMP PF14996.4 NM_026005.3_1 - 4.1e-56 189.4 6.4 6.1e-56 188.8 6.4 1.2 1 0 0 1 1 1 1 Retinal Maintenance PDEase_I PF00233.17 NM_001170669.1_1 - 5.5e-91 304.4 1.5 9.5e-91 303.6 1.5 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDE8 PF08629.8 NM_001170669.1_1 - 7.4e-29 99.4 2.7 7.4e-29 99.4 2.7 2.3 3 0 0 3 3 3 1 PDE8 phosphodiesterase EF-hand_7 PF13499.4 NM_145144.1_1 - 0.036 14.4 0.1 0.054 13.8 0.1 1.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.4 NM_145144.1_1 - 0.092 12.6 0.2 0.25 11.3 0.1 1.7 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.30 NM_145144.1_1 - 0.3 10.6 1.3 1.6 8.3 0.6 2.2 2 0 0 2 2 2 0 EF hand Dec-1 PF04624.12 NM_145144.1_3 - 0.13 12.0 1.1 0.37 10.5 1.1 1.8 1 0 0 1 1 1 0 Dec-1 repeat RhoGEF PF00621.18 NM_001033272.2_2 - 2.3e-45 154.9 3.8 4.2e-45 154.1 3.8 1.5 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 NM_001033272.2_2 - 6.6e-10 38.3 2.4 1.2e-09 37.5 2.4 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001033272.2_2 - 2.3e-09 36.8 0.1 5.2e-09 35.7 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 NM_001033272.2_2 - 2.6e-07 31.0 0.2 6.1e-07 29.8 0.2 1.6 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.15 NM_001033272.2_2 - 8.9e-07 28.4 0.0 1.9e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Myosin_TH1 PF06017.11 NM_001033272.2_2 - 0.13 11.8 0.1 0.21 11.1 0.1 1.2 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding OCIA PF07051.9 NM_026950.4_1 - 1.2e-34 118.0 0.0 1.9e-34 117.4 0.0 1.3 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) Fox-1_C PF12414.6 NM_001286418.1_2 - 1.1e-43 147.3 22.7 2.7e-43 146.1 22.7 1.7 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal O-FucT PF10250.7 NM_030262.3_3 - 6.9e-67 226.2 0.0 8.8e-67 225.9 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Asp PF00026.21 NM_011792.6_1 - 2.4e-44 151.9 0.0 3.1e-44 151.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.4 NM_011792.6_1 - 1.6e-10 40.8 0.0 2.4e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.4 NM_011792.6_1 - 5.7e-06 26.6 0.0 0.011 15.9 0.0 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal ADH_N_2 PF16884.3 NM_025968.3_1 - 1e-37 128.2 0.0 1.6e-37 127.5 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.24 NM_025968.3_1 - 2e-23 82.6 0.0 3.1e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 NM_025968.3_1 - 9.9e-10 39.4 0.0 2.2e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ANXA2R PF15721.3 NM_001302966.1_3 - 2.9e-62 210.5 10.9 4.3e-62 209.9 10.9 1.3 1 0 0 1 1 1 1 Annexin-2 receptor PPI_Ypi1 PF07491.9 NM_029632.3_2 - 9.4e-21 73.3 4.3 2.2e-20 72.1 4.3 1.5 1 0 0 1 1 1 1 Protein phosphatase inhibitor Histone PF00125.22 NM_178199.2_1 - 6.6e-26 91.1 0.7 8.8e-26 90.7 0.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_178199.2_1 - 8.2e-07 29.1 1.0 1.1e-06 28.6 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 NM_178199.2_1 - 0.0014 19.0 0.0 0.0025 18.2 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.3 NM_178199.2_1 - 0.0027 17.6 0.3 0.0033 17.3 0.3 1.1 1 0 0 1 1 1 1 YscO-like protein Yae1_N PF09811.7 NM_178199.2_3 - 0.14 11.7 4.1 0.42 10.2 4.1 1.9 1 0 0 1 1 1 0 Essential protein Yae1, N terminal COMM_domain PF07258.12 NM_133850.2_3 - 2.1e-17 62.8 0.1 4.2e-17 61.9 0.1 1.5 1 0 0 1 1 1 1 COMM domain Ets PF00178.20 NM_001302179.1_2 - 8.4e-36 122.2 0.5 1.5e-35 121.4 0.5 1.4 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 NM_001302179.1_2 - 3e-25 87.9 0.0 5.5e-25 87.0 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain V1R PF03402.12 NM_001167148.1_1 - 2.7e-15 56.6 12.4 3.7e-15 56.2 12.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001167148.1_1 - 2.8e-14 52.8 14.7 3.9e-14 52.3 14.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001167148.1_1 - 1.1e-05 24.7 13.2 1.5e-05 24.2 13.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PRP8_domainIV PF12134.6 NM_001167148.1_1 - 0.084 12.4 0.2 0.97 8.9 0.0 2.4 3 0 0 3 3 3 0 PRP8 domain IV core DUF1700 PF08006.9 NM_001167148.1_1 - 0.091 12.2 6.6 0.18 11.2 1.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Peptidase_M7 PF02031.14 NM_001167148.1_1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family AgrB PF04647.13 NM_001167148.1_1 - 4.5 6.4 15.2 1.4 8.1 0.6 2.7 3 0 0 3 3 3 0 Accessory gene regulator B Fer4_4 PF12800.5 NM_001167148.1_3 - 0.5 10.9 0.1 0.5 10.9 0.1 4.8 5 0 0 5 5 5 0 4Fe-4S binding domain Fer4 PF00037.25 NM_001167148.1_3 - 1.4 8.8 8.7 0.85 9.4 1.2 3.3 3 0 0 3 3 3 0 4Fe-4S binding domain Adaptin_N PF01602.18 NM_007455.5_1 - 3.1e-149 497.8 0.2 3.7e-149 497.5 0.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.18 NM_007455.5_1 - 1.2e-29 102.7 0.1 2.9e-29 101.4 0.1 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.5 NM_007455.5_1 - 2.7e-11 43.6 0.5 1.1e-06 28.6 0.0 3.3 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Kinetochor_Ybp2 PF08568.8 NM_007455.5_1 - 0.013 13.8 0.3 0.022 13.1 0.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family, YAP/Alf4/glomulin Sdh_cyt PF01127.20 NM_007455.5_1 - 0.14 12.1 0.1 0.28 11.1 0.1 1.5 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit GDNF PF02351.14 NM_205844.3_1 - 2.8e-19 69.7 49.2 2.3e-10 41.2 11.9 3.5 3 1 0 3 3 3 2 GDNF/GAS1 domain Hormone_recep PF00104.28 NM_011306.4_1 - 6.1e-39 133.6 0.0 9.2e-39 133.0 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_011306.4_1 - 1.7e-31 108.3 16.7 2.9e-31 107.6 16.7 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Nuc_recep-AF1 PF11825.6 NM_011306.4_1 - 1.4e-05 25.0 14.0 2.6e-05 24.1 14.0 1.4 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 TUDOR PF00567.22 NM_028034.2_1 - 2.3e-25 88.9 1.6 4.6e-25 87.9 1.6 1.5 1 0 0 1 1 1 1 Tudor domain Guanylate_kin PF00625.19 NM_016695.3_3 - 1.2e-45 155.4 0.0 1.9e-45 154.7 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase L27 PF02828.14 NM_016695.3_3 - 4.5e-29 99.9 3.8 5e-17 61.3 1.5 2.8 3 0 0 3 3 3 2 L27 domain SH3_2 PF07653.15 NM_016695.3_3 - 4.3e-10 39.0 0.1 1.1e-09 37.7 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain PDZ PF00595.22 NM_016695.3_3 - 4.9e-08 33.1 1.0 8.7e-08 32.3 0.5 1.7 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) SH3_1 PF00018.26 NM_016695.3_3 - 7.3e-06 25.4 0.0 1.4e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain PDZ_2 PF13180.4 NM_016695.3_3 - 0.00013 22.1 0.0 0.00028 21.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 NM_016695.3_3 - 0.00056 19.7 0.0 0.024 14.5 0.0 2.6 2 1 0 2 2 2 1 Tricorn protease PDZ domain SH3_9 PF14604.4 NM_016695.3_3 - 0.013 15.2 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain AstE_AspA PF04952.12 NM_023113.5_1 - 4.5e-69 232.6 0.0 5.3e-69 232.4 0.0 1.1 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF3709 PF12493.6 NM_023113.5_2 - 0.02 14.8 2.7 0.052 13.5 2.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3709) IRK PF01007.18 NM_001110227.2_3 - 9.9e-90 300.7 0.0 1.6e-89 300.0 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_001110227.2_3 - 0.00011 22.0 0.6 0.00011 22.0 0.6 2.1 2 0 0 2 2 2 1 Ion channel NYD-SP28 PF14772.4 NM_153518.1_2 - 1e-28 99.2 10.1 1e-28 99.2 10.1 4.7 5 1 1 6 6 6 1 Sperm tail FANCI_S2 PF14676.4 NM_153518.1_2 - 0.13 12.4 2.2 8.5 6.5 0.0 2.6 2 0 0 2 2 2 0 FANCI solenoid 2 PDGF PF00341.15 NM_011057.3_1 - 3.1e-22 78.5 10.4 3.1e-22 78.5 10.4 2.3 2 0 0 2 2 2 1 PDGF/VEGF domain PDGF_N PF04692.11 NM_011057.3_1 - 4e-17 62.7 0.3 8e-17 61.7 0.3 1.5 1 0 0 1 1 1 1 Platelet-derived growth factor, N terminal region ELO PF01151.16 NM_148941.2_1 - 6.3e-66 222.3 21.5 1e-65 221.6 21.5 1.3 1 0 0 1 1 1 1 GNS1/SUR4 family UPAR_LY6 PF00021.19 NM_029806.1_1 - 3.7e-18 65.8 14.5 4.4e-17 62.4 10.5 2.7 2 1 0 2 2 2 2 u-PAR/Ly-6 domain WAC_Acf1_DNA_bd PF10537.7 NM_011714.2_1 - 1e-25 90.0 2.2 5.3e-25 87.7 2.2 2.4 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal Bromodomain PF00439.23 NM_011714.2_1 - 6.4e-21 74.1 0.1 1.3e-20 73.1 0.1 1.5 1 0 0 1 1 1 1 Bromodomain WSD PF15613.4 NM_011714.2_1 - 6.6e-21 74.6 0.1 6.6e-21 74.6 0.1 4.3 4 0 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD PF00628.27 NM_011714.2_1 - 3.7e-13 49.0 5.8 1.4e-12 47.1 5.8 2.2 1 0 0 1 1 1 1 PHD-finger WHIM1 PF15612.4 NM_011714.2_1 - 2.5e-08 33.2 0.2 8.9e-08 31.4 0.2 2.1 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 zf-HC5HC2H PF13771.4 NM_011714.2_1 - 0.0063 16.6 1.6 0.026 14.6 1.6 2.0 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-RING_2 PF13639.4 NM_011714.2_1 - 0.024 14.8 5.7 0.078 13.1 5.7 2.0 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.5 NM_011714.2_1 - 0.092 12.9 6.7 0.27 11.4 6.7 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain DDT PF02791.15 NM_011714.2_1 - 0.28 11.4 1.9 0.31 11.3 0.3 1.9 2 0 0 2 2 2 0 DDT domain Prok-RING_1 PF14446.4 NM_011714.2_1 - 2.6 7.9 13.1 0.041 13.7 1.5 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 GSHPx PF00255.17 NM_030677.2_3 - 3.7e-39 132.5 0.1 4.8e-39 132.1 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Mab-21 PF03281.12 NM_001163528.1_1 - 1.5e-12 47.3 0.1 8.9e-12 44.8 0.1 2.0 1 1 0 1 1 1 1 Mab-21 protein UEV PF05743.11 NM_021884.3_3 - 1.6e-47 160.2 0.5 3e-46 156.1 0.2 2.3 2 0 0 2 2 2 1 UEV domain Vps23_core PF09454.8 NM_021884.3_3 - 6.5e-28 96.3 0.1 1.2e-27 95.5 0.1 1.4 1 0 0 1 1 1 1 Vps23 core domain DUF3450 PF11932.6 NM_021884.3_3 - 0.0011 18.2 7.5 0.0021 17.2 7.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) APG6 PF04111.10 NM_021884.3_3 - 0.0012 18.2 3.5 0.0018 17.6 3.5 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 GPS2_interact PF15784.3 NM_021884.3_3 - 0.019 15.5 5.8 0.019 15.5 5.8 1.7 2 0 0 2 2 1 0 G-protein pathway suppressor 2-interacting domain UQ_con PF00179.24 NM_021884.3_3 - 0.028 14.0 1.9 0.041 13.4 0.4 2.1 2 0 0 2 2 2 0 Ubiquitin-conjugating enzyme DUF1640 PF07798.9 NM_021884.3_3 - 0.063 13.2 6.7 0.064 13.2 5.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) IncA PF04156.12 NM_021884.3_3 - 0.066 12.9 3.5 0.12 12.0 3.5 1.4 1 0 0 1 1 1 0 IncA protein Macoilin PF09726.7 NM_021884.3_3 - 0.088 11.2 2.5 0.12 10.8 2.5 1.1 1 0 0 1 1 1 0 Transmembrane protein Fzo_mitofusin PF04799.11 NM_021884.3_3 - 0.09 12.2 3.6 0.17 11.3 3.6 1.4 1 0 0 1 1 1 0 fzo-like conserved region Spc7 PF08317.9 NM_021884.3_3 - 0.13 11.0 9.2 0.19 10.4 9.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein TBPIP PF07106.11 NM_021884.3_3 - 0.17 11.5 6.7 0.29 10.8 6.7 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ERM PF00769.17 NM_021884.3_3 - 0.18 11.4 12.4 0.32 10.6 12.4 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF342 PF03961.11 NM_021884.3_3 - 0.28 9.6 4.2 0.41 9.1 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Nsp1_C PF05064.11 NM_021884.3_3 - 0.31 10.7 4.7 0.81 9.4 4.7 1.7 1 0 0 1 1 1 0 Nsp1-like C-terminal region DUF3552 PF12072.6 NM_021884.3_3 - 0.57 9.4 10.4 0.95 8.7 10.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF3782 PF12644.5 NM_021884.3_3 - 0.59 10.2 4.0 9.7 6.3 0.0 3.3 1 1 3 4 4 4 0 Protein of unknown function (DUF3782) Fib_alpha PF08702.8 NM_021884.3_3 - 0.69 10.0 4.0 1.6 8.8 4.0 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family SlyX PF04102.10 NM_021884.3_3 - 0.8 10.2 10.0 0.25 11.9 3.5 2.9 2 1 1 3 3 3 0 SlyX Spc24 PF08286.9 NM_021884.3_3 - 0.83 9.8 11.4 1.3 9.1 5.2 2.5 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF1664 PF07889.10 NM_021884.3_3 - 1.1 9.1 4.0 2 8.3 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4164 PF13747.4 NM_021884.3_3 - 2.5 8.3 8.9 0.77 9.9 1.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) FlaC_arch PF05377.9 NM_021884.3_3 - 3.4 8.0 10.3 7.6 6.9 0.4 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF4140 PF13600.4 NM_021884.3_3 - 3.4 8.0 5.8 28 5.1 5.8 2.2 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF724 PF05266.12 NM_021884.3_3 - 4.2 7.0 8.3 7.6 6.2 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DivIC PF04977.13 NM_021884.3_3 - 6.3 6.5 11.7 4.8 6.9 0.9 2.5 1 1 1 2 2 2 0 Septum formation initiator HrpB7 PF09486.8 NM_021884.3_3 - 8 6.7 8.6 1.1 9.6 4.6 1.5 2 0 0 2 2 1 0 Bacterial type III secretion protein (HrpB7) F-box-like PF12937.5 NM_001081490.2_2 - 1.2e-09 37.8 1.8 2.2e-09 36.9 1.8 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_001081490.2_2 - 9.8e-08 31.6 2.1 1.8e-07 30.7 2.1 1.5 1 0 0 1 1 1 1 F-box domain MIT PF04212.16 NM_001081490.2_2 - 0.00041 20.2 0.2 0.00076 19.4 0.2 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_2 PF07719.15 NM_001081490.2_2 - 0.034 14.1 0.9 0.19 11.8 0.4 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001081490.2_2 - 0.13 12.0 0.1 0.34 10.7 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-CXXC PF02008.18 NM_001004367.4_1 - 1.3e-06 28.1 18.9 1.3e-06 28.1 18.9 2.3 2 0 0 2 2 2 1 CXXC zinc finger domain RCDG1 PF15725.3 NM_001004367.4_3 - 1.8 8.9 9.9 4.6 7.6 9.9 1.7 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein CAP_N PF01213.17 NM_001004367.4_3 - 4.7 6.5 6.6 8.3 5.7 6.6 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CTF_NFI PF00859.16 NM_010906.3_2 - 3.3e-06 27.1 0.1 6.6e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region CTF_NFI PF00859.16 NM_010906.3_3 - 9.1e-71 239.1 22.1 2.4e-47 162.2 3.4 2.8 2 1 1 3 3 3 2 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.7 NM_010906.3_3 - 5.3e-27 93.3 2.6 9.2e-27 92.6 2.6 1.4 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.14 NM_010906.3_3 - 3.8e-10 39.8 0.1 6.5e-10 39.0 0.1 1.4 1 0 0 1 1 1 1 MH1 domain UPF0693 PF16088.3 NM_025563.3_1 - 3.7e-35 120.2 0.8 5.4e-35 119.6 0.8 1.2 1 0 0 1 1 1 1 UPF0693 family Ion_trans_2 PF07885.14 NM_010609.2_1 - 5.6e-25 87.0 1.0 3e-12 46.2 0.0 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.29 NM_010609.2_1 - 0.0017 17.5 0.0 0.47 9.5 0.0 2.3 1 1 1 2 2 2 2 Ion transport protein NEMP PF10225.7 NM_001113211.1_1 - 1.7e-90 303.0 5.9 2.9e-90 302.2 5.9 1.4 1 0 0 1 1 1 1 NEMP family Carn_acyltransf PF00755.18 NM_013495.2_1 - 5.4e-196 652.6 0.0 6.4e-196 652.3 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 NM_013495.2_1 - 2.6e-27 94.4 0.1 5e-27 93.5 0.1 1.5 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus FKBP_C PF00254.26 NM_008019.3_1 - 2.3e-33 114.2 0.0 3.5e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase V-set PF07686.15 NM_001310738.1_1 - 3e-08 33.7 0.3 1.5e-07 31.4 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001310738.1_1 - 0.00012 22.5 0.2 0.025 15.1 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 NM_001310738.1_1 - 0.0035 17.3 0.4 0.012 15.5 0.2 2.0 1 1 1 2 2 2 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 NM_001310738.1_1 - 0.042 13.8 0.0 0.14 12.1 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin I-set domain Presenilin PF01080.15 NM_001310738.1_2 - 8.7 4.8 10.8 12 4.4 10.8 1.1 1 0 0 1 1 1 0 Presenilin LRR_4 PF12799.5 NM_028821.3_1 - 1.6e-09 37.7 11.5 0.00025 21.2 6.4 3.4 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_028821.3_1 - 1.8e-07 30.7 0.7 0.00031 20.2 0.0 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.4 NM_028821.3_1 - 0.00022 20.8 8.1 0.055 13.1 3.4 2.7 2 1 0 2 2 2 2 Leucine rich repeat Yae1_N PF09811.7 NM_028821.3_3 - 4.3 7.0 17.0 60 3.3 17.0 2.5 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Ion_trans PF00520.29 NM_001109897.2_3 - 8.1e-25 87.3 23.6 8.1e-25 87.3 23.6 2.1 2 1 0 2 2 2 1 Ion transport protein TRP_2 PF08344.9 NM_001109897.2_3 - 1.7e-22 79.2 1.6 3.4e-22 78.3 1.6 1.5 1 0 0 1 1 1 1 Transient receptor ion channel II PKD_channel PF08016.10 NM_001109897.2_3 - 1.3e-10 40.5 12.2 1.8e-10 39.9 12.2 1.2 1 0 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.5 NM_001109897.2_3 - 1.3e-06 28.8 0.0 0.0066 16.9 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_001109897.2_3 - 0.052 14.0 0.2 8.7 7.1 0.0 3.9 4 0 0 4 4 4 0 Ankyrin repeat Ank PF00023.28 NM_001109897.2_3 - 0.17 12.3 1.9 0.58 10.6 0.0 2.9 3 0 0 3 3 3 0 Ankyrin repeat Glyco_transf_29 PF00777.16 NM_145933.4_1 - 9.5e-35 120.1 0.0 1.5e-34 119.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) zf-CCCH PF00642.22 NM_001282013.1_3 - 0.00019 21.2 7.2 0.00019 21.2 7.2 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) K_channel_TID PF07941.9 NM_001282013.1_3 - 0.71 10.2 7.8 1.4 9.3 7.8 1.4 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Troponin PF00992.18 NM_011620.3_2 - 2.2e-33 115.3 34.7 2.2e-33 115.3 34.7 3.0 2 1 1 3 3 3 2 Troponin FAM177 PF14774.4 NM_028527.1_1 - 2.4e-44 150.3 0.1 4e-44 149.6 0.1 1.3 1 0 0 1 1 1 1 FAM177 family LIM PF00412.20 NM_024223.2_1 - 1.2e-26 92.5 19.9 4.9e-14 52.2 4.7 2.4 2 0 0 2 2 2 2 LIM domain DiS_P_DiS PF06750.11 NM_024223.2_1 - 0.034 14.1 3.4 1.8 8.6 0.3 2.7 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain Mut7-C PF01927.14 NM_024223.2_1 - 0.3 11.1 7.0 2.6 8.0 0.9 2.3 2 0 0 2 2 2 0 Mut7-C RNAse domain Pea-VEAacid PF08111.9 NM_024223.2_1 - 0.67 10.3 2.6 39 4.7 0.2 2.6 2 0 0 2 2 2 0 Pea-VEAacid family Metallothio_Pro PF02069.14 NM_024223.2_1 - 3.6 7.8 12.2 8.3 6.6 0.8 3.5 2 1 1 3 3 3 0 Prokaryotic metallothionein zf-DNA_Pol PF08996.8 NM_024223.2_1 - 3.8 7.1 7.6 5.6 6.5 1.1 2.2 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger DUF329 PF03884.12 NM_024223.2_1 - 5.3 6.7 19.5 21 4.8 0.1 4.5 3 1 1 4 4 4 0 Domain of unknown function (DUF329) Laminin_N PF00055.15 NM_133488.1_1 - 6.1e-54 183.0 0.0 6.1e-54 183.0 0.0 2.0 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.22 NM_133488.1_1 - 2.5e-06 27.4 11.3 2.5e-06 27.4 11.3 3.7 3 0 0 3 3 3 1 Laminin EGF domain EGF_2 PF07974.11 NM_133488.1_1 - 0.52 10.6 26.8 0.014 15.6 8.4 3.8 3 0 0 3 3 3 0 EGF-like domain EVI2A PF05399.9 NM_010161.3_1 - 4.8e-102 340.3 3.2 6.2e-102 340.0 3.2 1.1 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) HemY_N PF07219.11 NM_010161.3_1 - 0.063 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 HemY protein N-terminus TMEM154 PF15102.4 NM_010161.3_1 - 0.074 12.8 0.9 0.12 12.1 0.6 1.5 1 1 0 1 1 1 0 TMEM154 protein family Peptidase_M56 PF05569.9 NM_010161.3_1 - 0.085 11.9 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 V1R PF03402.12 NM_001167163.1_1 - 8e-16 58.3 10.4 1e-15 57.9 10.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001167163.1_1 - 1.3e-14 54.0 12.9 1.6e-14 53.6 12.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001167163.1_1 - 5.7e-05 22.4 12.5 8e-05 21.9 12.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1700 PF08006.9 NM_001167163.1_1 - 0.026 13.9 4.2 0.1 12.0 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Anoctamin PF04547.10 NM_001167163.1_1 - 0.17 10.5 5.5 0.061 12.0 2.9 1.4 1 1 0 1 1 1 0 Calcium-activated chloride channel Fer4_4 PF12800.5 NM_001167163.1_3 - 0.17 12.3 8.2 20 5.9 1.1 4.0 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_6 PF12837.5 NM_001167163.1_3 - 1.3 9.1 6.8 0.4 10.7 0.7 3.0 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_3 PF12798.5 NM_001167163.1_3 - 4.9 8.2 14.0 2.9 8.9 3.0 4.2 3 0 0 3 3 3 0 4Fe-4S binding domain Isochorismatase PF00857.18 NM_001101598.1_1 - 3.5e-25 89.0 0.0 6.2e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family C6_DPF PF10170.7 NM_001164625.1_2 - 9.5e-37 125.2 4.1 1.4e-36 124.7 4.1 1.2 1 0 0 1 1 1 1 Cysteine-rich domain Nup88 PF10168.7 NM_001276406.1_2 - 0 1020.2 0.0 0 1020.0 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore component BLOC1_2 PF10046.7 NM_001276406.1_2 - 1.5 9.0 6.4 15 5.8 2.4 2.7 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FliJ PF02050.14 NM_001276406.1_2 - 1.9 8.6 17.8 1.5 8.9 9.8 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein APG6 PF04111.10 NM_001276406.1_2 - 2.6 7.2 11.2 4.1 6.6 11.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Latarcin PF10279.7 NM_001276406.1_2 - 5.7 7.3 7.7 5.6 7.3 5.3 2.1 2 0 0 2 2 2 0 Latarcin precursor Exonuc_VII_L PF02601.13 NM_001276406.1_2 - 8.8 5.7 7.5 16 4.8 7.5 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4195 PF13836.4 NM_177475.3_2 - 5.1e-35 121.1 14.7 9.1e-35 120.3 14.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4195) zf-H2C2_2 PF13465.4 NM_177475.3_2 - 0.00012 22.2 27.3 0.045 14.1 0.4 6.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-Di19 PF05605.10 NM_177475.3_2 - 0.0071 16.5 0.9 0.0071 16.5 0.9 4.6 2 1 1 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 NM_177475.3_2 - 0.14 12.4 0.1 0.14 12.4 0.1 3.9 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_177475.3_2 - 6.1 7.2 17.3 1.4 9.3 0.1 4.7 4 0 0 4 4 4 0 Zinc-finger of C2H2 type ACBP PF00887.17 NM_026683.1_3 - 5.7e-24 84.0 0.4 8.3e-24 83.5 0.4 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein RasGAP PF00616.17 NM_027711.1_1 - 4.5e-58 196.3 0.0 4.5e-58 196.3 0.0 2.7 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.13 NM_027711.1_1 - 5.9e-37 126.7 9.7 5.9e-37 126.7 9.7 4.0 3 0 0 3 3 3 1 RasGAP C-terminus CH PF00307.29 NM_027711.1_1 - 1.4e-16 60.5 0.0 1.2e-15 57.5 0.0 2.8 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ PF00612.25 NM_027711.1_1 - 7.6e-14 50.0 0.1 0.00029 20.2 0.0 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif Cadherin PF00028.15 NM_017392.3_1 - 1.1e-174 567.3 11.9 2.6e-22 78.9 0.0 9.4 9 0 0 9 9 9 9 Cadherin domain GAIN PF16489.3 NM_017392.3_1 - 1.8e-61 207.1 0.0 3.3e-61 206.2 0.0 1.5 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Laminin_G_2 PF02210.22 NM_017392.3_1 - 3.7e-46 156.6 0.2 2.1e-25 89.6 0.0 2.7 2 0 0 2 2 2 2 Laminin G domain 7tm_2 PF00002.22 NM_017392.3_1 - 1.5e-44 152.0 7.9 2.4e-44 151.4 7.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Laminin_G_1 PF00054.21 NM_017392.3_1 - 1.9e-23 83.0 0.1 2e-14 53.8 0.0 3.5 2 1 0 2 2 2 2 Laminin G domain GPS PF01825.19 NM_017392.3_1 - 2e-15 57.0 3.4 2e-15 57.0 3.4 2.4 2 0 0 2 2 1 1 GPCR proteolysis site, GPS, motif Cadherin_3 PF16184.3 NM_017392.3_1 - 1.7e-11 44.0 13.0 0.013 15.4 0.2 8.0 9 0 0 9 9 9 2 Cadherin-like EGF PF00008.25 NM_017392.3_1 - 2.4e-11 43.6 110.5 9.8e-06 25.6 6.7 9.3 10 0 0 10 10 9 6 EGF-like domain Laminin_EGF PF00053.22 NM_017392.3_1 - 5.2e-09 36.0 12.5 5.2e-09 36.0 12.5 8.7 6 2 3 9 9 9 2 Laminin EGF domain Cadherin_2 PF08266.10 NM_017392.3_1 - 1.2e-06 28.1 0.1 3 7.6 0.0 6.7 8 0 0 8 8 8 1 Cadherin-like Cadherin_pro PF08758.9 NM_017392.3_1 - 7.5e-06 25.9 0.0 0.19 11.8 0.0 4.4 5 0 0 5 5 5 1 Cadherin prodomain like hEGF PF12661.5 NM_017392.3_1 - 0.00022 21.6 21.6 0.00079 19.9 6.8 9.3 9 0 0 9 9 7 4 Human growth factor-like EGF Dicty_CAR PF05462.9 NM_017392.3_1 - 0.0028 16.7 1.3 0.0051 15.8 1.3 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor TNFR_c6 PF00020.16 NM_001033126.2_1 - 1.6e-05 25.1 8.0 1.6e-05 25.1 8.0 4.4 4 0 0 4 4 4 2 TNFR/NGFR cysteine-rich region UPA PF17217.1 NM_001293561.1_1 - 1.8e-71 238.5 0.5 3.2e-71 237.7 0.5 1.4 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.18 NM_001293561.1_1 - 5.7e-33 113.0 0.0 1.2e-32 112.0 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain Death PF00531.20 NM_001293561.1_1 - 9.8e-14 51.2 0.0 2.3e-13 50.0 0.0 1.6 1 0 0 1 1 1 1 Death domain Ig_3 PF13927.4 NM_001293561.1_1 - 4.3e-11 43.1 0.2 7.7e-08 32.7 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 NM_001293561.1_1 - 1.4e-10 40.9 1.7 9.3e-10 38.3 0.0 2.7 3 0 0 3 3 3 1 Immunoglobulin I-set domain TSP_1 PF00090.17 NM_001293561.1_1 - 9.3e-09 35.2 31.3 1.5e-07 31.4 8.8 3.5 3 0 0 3 3 3 2 Thrombospondin type 1 domain Ig_2 PF13895.4 NM_001293561.1_1 - 1.3e-05 25.3 0.0 0.00022 21.4 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.23 NM_001293561.1_1 - 9.4e-05 22.4 0.0 0.00048 20.1 0.0 2.3 3 0 0 3 3 3 1 Immunoglobulin domain CLCA PF08434.9 NM_030601.3_2 - 0 1096.8 0.2 0 1096.4 0.2 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel VWA_2 PF13519.4 NM_030601.3_2 - 8.9e-13 48.7 0.2 2.3e-12 47.4 0.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 NM_030601.3_2 - 9.8e-13 48.6 0.1 1.7e-12 47.8 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 NM_030601.3_2 - 0.00013 21.3 0.0 0.00025 20.4 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein A2M_N PF01835.17 NM_030601.3_2 - 0.00085 19.6 0.0 0.0029 17.9 0.0 1.9 1 0 0 1 1 1 1 MG2 domain vWA-TerF-like PF10138.7 NM_030601.3_2 - 0.13 12.2 0.0 0.38 10.7 0.0 1.7 2 0 0 2 2 2 0 vWA found in TerF C terminus P2X_receptor PF00864.17 NM_145526.2_2 - 1.1e-147 491.8 1.1 1.4e-147 491.5 1.1 1.1 1 0 0 1 1 1 1 ATP P2X receptor zf-RING_6 PF14835.4 NM_145526.2_2 - 0.0028 17.4 0.0 0.0065 16.2 0.0 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein DUF2798 PF11391.6 NM_145526.2_2 - 1.7 8.6 7.6 4.6 7.2 7.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2798) Myb_DNA-bind_4 PF13837.4 NM_001277487.1_1 - 8.7e-06 25.9 0.6 0.0065 16.7 0.3 2.4 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain Homeobox PF00046.27 NM_010920.2_1 - 4.2e-20 71.2 4.5 7.4e-20 70.4 4.5 1.4 1 0 0 1 1 1 1 Homeobox domain Abhydrolase_1 PF00561.18 NM_023475.3_2 - 5.7e-18 65.3 0.1 9.2e-18 64.7 0.1 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_023475.3_2 - 2.3e-11 44.6 0.0 3.2e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 NM_023475.3_2 - 2.8e-08 33.2 0.0 4e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 NM_023475.3_2 - 0.00085 18.0 0.0 0.0016 17.0 0.0 1.4 1 0 0 1 1 1 1 Ndr family PGAP1 PF07819.11 NM_023475.3_2 - 0.021 14.4 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.5 NM_023475.3_2 - 0.041 13.5 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.23 NM_023475.3_2 - 0.089 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) ITAM PF02189.13 NM_001113391.2_2 - 3.6e-19 67.8 4.1 1.3e-05 25.2 0.1 3.4 3 0 0 3 3 3 3 Immunoreceptor tyrosine-based activation motif TCR_zetazeta PF11628.6 NM_001113391.2_2 - 2.1e-17 62.4 1.5 2.1e-17 62.4 1.5 1.9 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 zeta chain 7tm_4 PF13853.4 NM_011002.2_3 - 6.7e-58 196.5 18.8 8.1e-58 196.2 18.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_011002.2_3 - 3.2e-26 92.0 24.2 6.6e-26 91.0 24.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_011002.2_3 - 0.00073 18.9 20.8 0.0011 18.3 20.8 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_011002.2_3 - 0.14 11.3 18.8 0.1 11.7 17.0 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx RRM_1 PF00076.20 NM_001253759.1_1 - 1.3e-08 34.4 0.0 2.9e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001253759.1_1 - 0.009 16.0 0.1 0.066 13.2 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif SesA PF17107.3 NM_001253759.1_1 - 0.56 10.3 11.2 8.8 6.4 6.6 2.7 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Pkinase PF00069.23 NM_011950.2_1 - 9.1e-70 234.9 0.0 1.2e-69 234.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_011950.2_1 - 5.7e-29 101.1 0.1 8.1e-29 100.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_011950.2_1 - 0.00056 19.8 0.1 0.0013 18.6 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_011950.2_1 - 0.0016 17.7 0.1 0.0033 16.7 0.1 1.6 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_011950.2_1 - 0.013 14.7 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BNR_2 PF13088.4 NM_173772.3_1 - 8.2e-31 107.2 0.0 7e-26 91.0 0.0 2.1 2 0 0 2 2 2 2 BNR repeat-like domain BNR_3 PF13859.4 NM_173772.3_1 - 9.4e-06 25.0 0.0 1.3e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 NM_173772.3_1 - 0.28 11.2 6.1 0.15 12.1 0.9 3.3 4 0 0 4 4 4 0 BNR/Asp-box repeat Pro-rich_19 PF15455.4 NM_001081294.1_3 - 2.9e-192 638.5 30.4 3.4e-192 638.3 30.4 1.0 1 0 0 1 1 1 1 Proline-rich 19 Drf_FH1 PF06346.10 NM_001286016.1_1 - 0.011 15.3 13.0 0.018 14.6 13.0 1.3 1 0 0 1 1 1 0 Formin Homology Region 1 Casein PF00363.16 NM_001286016.1_2 - 4.7e-10 39.8 6.9 4.7e-10 39.8 6.9 3.8 3 1 1 4 4 4 1 Casein NupH_GANP PF16768.3 NM_001286016.1_2 - 0.019 14.6 12.3 0.1 12.2 12.3 2.1 1 1 0 1 1 1 0 Nucleoporin homology of Germinal-centre associated nuclear protein RNA_pol_Rbc25 PF08292.10 NM_001286016.1_2 - 0.56 10.3 2.6 1.3 9.1 2.6 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 FAM110_C PF14160.4 NM_001286016.1_2 - 0.96 10.4 6.3 0.54 11.2 3.8 1.8 2 0 0 2 2 2 0 Centrosome-associated C terminus TRAM_LAG1_CLN8 PF03798.14 NM_001291235.1_3 - 1.6e-15 57.3 12.0 2e-15 56.9 12.0 1.1 1 0 0 1 1 1 1 TLC domain adh_short PF00106.23 NM_013786.2_2 - 6.4e-38 130.1 0.0 8.7e-38 129.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_013786.2_2 - 1.1e-22 80.6 0.0 1.6e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_013786.2_2 - 0.0067 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 KR domain MAJIN PF15077.4 NM_001165919.1_1 - 9e-127 421.8 0.3 1.1e-126 421.5 0.3 1.1 1 0 0 1 1 1 1 Membrane-anchored junction protein Ig_3 PF13927.4 NM_001160317.1_3 - 1.9e-74 246.1 0.1 2.8e-14 53.4 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 NM_001160317.1_3 - 1.5e-70 233.2 0.0 6.7e-14 51.6 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001160317.1_3 - 5.1e-47 158.0 0.0 7e-09 35.8 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 NM_001160317.1_3 - 1.2e-40 137.4 0.1 5.1e-07 29.6 0.0 7.2 7 0 0 7 7 7 6 Immunoglobulin domain fn3 PF00041.19 NM_001160317.1_3 - 9.3e-37 125.1 12.4 4e-12 46.2 0.1 4.6 4 0 0 4 4 4 4 Fibronectin type III domain Bravo_FIGEY PF13882.4 NM_001160317.1_3 - 7.8e-27 94.4 5.2 7.8e-27 94.4 5.2 1.8 2 0 0 2 2 1 1 Bravo-like intracellular region V-set PF07686.15 NM_001160317.1_3 - 1.2e-16 60.7 4.9 0.0022 18.0 0.0 8.6 7 3 2 9 9 9 3 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_001160317.1_3 - 1.1e-09 38.4 0.0 0.036 14.4 0.0 4.8 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 NM_001160317.1_3 - 2.8e-05 24.3 0.5 1.3 9.3 0.0 4.7 6 0 0 6 6 4 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.10 NM_001160317.1_3 - 4.8e-05 23.2 8.0 0.96 9.4 0.0 6.2 8 0 0 8 8 7 2 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 NM_001160317.1_3 - 0.0042 17.0 0.2 16 5.5 0.0 3.6 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain BiPBP_C PF06832.10 NM_001160317.1_3 - 0.0044 16.9 0.0 0.11 12.5 0.0 2.6 2 0 0 2 2 2 1 Penicillin-Binding Protein C-terminus Family Mpv17_PMP22 PF04117.10 NM_183170.2_1 - 1.2e-29 102.1 0.1 2.1e-29 101.4 0.1 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family Folate_rec PF03024.12 NM_144929.2_3 - 3.1e-36 124.7 2.1 4.6e-36 124.1 2.1 1.2 1 0 0 1 1 1 1 Folate receptor family LRR_8 PF13855.4 NM_001146021.1_3 - 6.5e-16 57.7 13.5 1.6e-09 37.2 2.2 3.6 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_001146021.1_3 - 2.9e-14 52.7 20.7 9.2e-06 25.8 0.1 4.9 2 2 3 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001146021.1_3 - 0.005 17.0 13.0 13 6.6 0.0 6.5 6 3 0 6 6 6 1 Leucine Rich Repeat LEDGF PF11467.6 NM_001146021.1_3 - 0.015 14.8 0.1 0.81 9.2 0.0 2.5 2 1 0 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) YgbA_NO PF11756.6 NM_001146021.1_3 - 0.081 13.2 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Nitrous oxide-stimulated promoter LRR_6 PF13516.4 NM_001146021.1_3 - 0.21 11.6 9.9 6.1 7.0 0.4 5.4 5 0 0 5 5 5 0 Leucine Rich repeat ABC_tran_Xtn PF12848.5 NM_001081395.1_2 - 0.27 11.1 5.8 0.46 10.4 5.8 1.3 1 0 0 1 1 1 0 ABC transporter Angiomotin_C PF12240.6 NM_001081395.1_3 - 3.2e-92 307.6 10.8 3.2e-92 307.6 10.8 3.8 3 1 0 3 3 3 2 Angiomotin C terminal DUF2967 PF11179.6 NM_001081395.1_3 - 0.97 8.7 22.3 0.32 10.3 19.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2967) BIR PF00653.19 NM_001301639.1_1 - 1.3e-60 201.8 9.6 3.6e-21 75.5 2.4 4.3 4 0 0 4 4 4 3 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.4 NM_001301639.1_1 - 4.2e-12 45.6 8.9 4.2e-12 45.6 8.9 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_001301639.1_1 - 1.1e-05 25.0 8.0 3.3e-05 23.5 8.0 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 V-set PF07686.15 NM_145391.2_3 - 8.4e-12 45.1 0.0 9.4e-11 41.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 NM_145391.2_3 - 8.8e-12 44.9 0.0 1.7e-07 31.2 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.13 NM_145391.2_3 - 7.1e-09 35.9 0.0 2.3e-08 34.3 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 NM_145391.2_3 - 7.8e-08 32.7 0.0 0.00011 22.6 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_145391.2_3 - 3.1e-05 24.1 0.0 0.033 14.4 0.0 3.0 1 1 1 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_145391.2_3 - 4.3e-05 23.4 0.0 0.0005 19.9 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin I-set domain Izumo-Ig PF16706.3 NM_145391.2_3 - 0.016 15.1 0.0 0.096 12.6 0.0 2.3 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.9 NM_145391.2_3 - 0.087 12.7 0.0 0.46 10.3 0.0 2.0 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Defensin_propep PF00879.16 NM_001177482.1_1 - 5.7e-22 77.7 0.7 1e-21 76.8 0.7 1.5 1 0 0 1 1 1 1 Defensin propeptide MF_alpha_N PF05436.9 NM_001177482.1_1 - 0.0035 17.1 0.1 0.0056 16.4 0.1 1.3 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus Peptidase_A22B PF04258.11 NM_010376.4_2 - 1.9e-102 342.5 7.7 2.5e-102 342.1 7.7 1.1 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.9 NM_010376.4_2 - 0.00014 21.3 6.5 0.00022 20.7 6.5 1.2 1 0 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease Presenilin PF01080.15 NM_010376.4_2 - 0.0039 15.9 2.0 0.007 15.0 2.0 1.4 1 0 0 1 1 1 1 Presenilin DUF4345 PF14248.4 NM_010376.4_2 - 0.0047 16.7 0.5 0.0047 16.7 0.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4345) 2TM PF13239.4 NM_010376.4_2 - 8.7 6.6 6.6 4.4 7.5 0.5 2.5 2 0 0 2 2 2 0 2TM domain UDPGT PF00201.16 NM_009467.3_2 - 3.3e-257 854.0 0.2 4.1e-257 853.7 0.2 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 NM_009467.3_2 - 6.9e-06 26.0 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_4 PF13579.4 NM_009467.3_2 - 0.09 13.1 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Methyltransf_8 PF05148.13 NM_025897.2_3 - 1.4e-103 345.4 0.0 1.8e-103 345.0 0.0 1.1 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.10 NM_025897.2_3 - 3.9e-07 30.5 0.1 1.1e-06 29.1 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_025897.2_3 - 7.3e-05 23.3 0.2 0.00049 20.6 0.2 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 NM_025897.2_3 - 0.054 12.7 0.0 0.086 12.0 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.10 NM_025897.2_3 - 0.24 12.0 1.1 6.5 7.4 0.0 2.6 2 1 1 3 3 3 0 Methyltransferase domain DUF3456 PF11938.6 NM_001305990.1_3 - 1e-20 74.7 1.4 1.6e-20 74.1 1.4 1.2 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP Opiods_neuropep PF01160.16 NM_001002927.2_3 - 1.8e-16 59.8 5.2 3.4e-16 58.9 5.2 1.5 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide Op_neuropeptide PF08035.9 NM_001002927.2_3 - 0.17 11.6 40.0 0.25 11.1 0.2 7.2 7 0 0 7 7 7 0 Opioids neuropeptide Filamin PF00630.17 NM_010227.3_3 - 0 1284.9 60.3 9.6e-20 71.2 0.6 24.2 24 0 0 24 24 24 24 Filamin/ABP280 repeat CH PF00307.29 NM_010227.3_3 - 1.9e-39 134.1 0.6 5.1e-21 74.8 0.8 2.5 2 0 0 2 2 2 2 Calponin homology (CH) domain Y_Y_Y PF07495.11 NM_010227.3_3 - 2.9e-18 65.5 15.1 0.18 11.6 0.0 13.3 14 0 0 14 14 14 4 Y_Y_Y domain DUF5060 PF16586.3 NM_010227.3_3 - 8.9e-14 51.5 0.3 12 6.3 0.0 13.9 18 0 0 18 18 16 1 Domain of unknown function (DUF5060) Big_3_5 PF16640.3 NM_010227.3_3 - 6.1e-12 45.4 49.8 0.58 10.2 0.0 16.6 18 0 0 18 18 18 5 Bacterial Ig-like domain (group 3) YtkA PF13115.4 NM_010227.3_3 - 3e-09 37.2 8.3 0.27 11.7 0.2 10.8 12 0 0 12 12 12 2 YtkA-like PapC_N PF13954.4 NM_010227.3_3 - 5.6e-05 23.0 0.0 2.4 8.0 0.0 6.6 5 1 1 6 6 6 1 PapC N-terminal domain EMP24_GP25L PF01105.22 NM_010227.3_3 - 0.0056 16.5 7.0 3.2 7.5 0.1 7.2 10 0 0 10 10 10 1 emp24/gp25L/p24 family/GOLD Invasin_D3 PF09134.8 NM_010227.3_3 - 0.011 15.4 8.2 9.8 5.9 0.0 8.1 10 0 0 10 10 10 0 Invasin, domain 3 CAMSAP_CH PF11971.6 NM_010227.3_3 - 0.032 13.9 0.1 2.3 8.0 0.1 2.6 2 0 0 2 2 2 0 CAMSAP CH domain CH_2 PF06294.9 NM_010227.3_3 - 0.16 11.9 0.4 3.4 7.7 0.2 2.2 2 0 0 2 2 2 0 CH-like domain in sperm protein CBM60 PF16841.3 NM_010227.3_3 - 0.65 10.3 4.4 21 5.5 0.1 5.1 5 0 0 5 5 4 0 Ca-dependent carbohydrate-binding module xylan-binding Rib PF08428.8 NM_010227.3_3 - 1.9 8.4 13.6 3.6 7.5 1.5 5.8 5 0 0 5 5 5 0 Rib/alpha-like repeat Glyoxalase PF00903.23 NM_026029.3_2 - 7.4e-07 29.3 0.0 0.0097 16.0 0.0 2.6 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.4 NM_026029.3_2 - 0.02 15.0 0.0 0.45 10.7 0.0 2.5 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.4 NM_026029.3_2 - 0.21 11.5 0.1 2.7 7.9 0.0 2.2 2 0 0 2 2 2 0 CppA N-terminal Collagen PF01391.16 NM_026778.2_1 - 1.8e-06 27.5 7.7 3e-06 26.8 7.7 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) V-set PF07686.15 NM_001128132.1_3 - 0.0002 21.4 0.0 0.00037 20.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001128132.1_3 - 0.00052 20.4 0.8 0.84 10.2 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_001128132.1_3 - 0.0062 16.7 0.7 1 9.6 0.0 2.5 1 1 1 2 2 2 2 Immunoglobulin domain CHGN PF05679.14 NM_001001565.2_3 - 2.2e-148 495.2 0.0 2.5e-148 495.0 0.0 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.14 NM_001001565.2_3 - 0.009 15.3 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 1 Fringe-like 7tm_4 PF13853.4 NM_146763.2_1 - 6.8e-54 183.4 20.0 8.3e-54 183.1 20.0 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146763.2_1 - 5.2e-16 58.5 21.3 5.2e-16 58.5 21.3 1.6 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_146763.2_1 - 0.99 8.9 5.8 0.19 11.1 1.2 2.2 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus zf-C2H2_assoc PF16606.3 NM_172385.2_3 - 3.8e-39 132.6 16.5 1.2e-38 131.0 16.5 2.0 1 0 0 1 1 1 1 Unstructured conserved, between two C2H2-type zinc-fingers zf-C2H2 PF00096.24 NM_172385.2_3 - 3.8e-31 105.7 73.3 2.4e-05 24.4 4.0 9.8 10 0 0 10 10 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_172385.2_3 - 1.3e-24 84.6 74.8 0.0023 18.5 2.8 10.6 10 0 0 10 10 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_172385.2_3 - 2.5e-21 75.0 77.3 9.7e-08 32.0 2.4 12.4 12 0 0 12 12 12 5 Zinc-finger double domain zf-H2C2_5 PF13909.4 NM_172385.2_3 - 1.9e-15 56.1 51.2 2.9e-07 30.0 0.9 9.6 9 0 0 9 9 9 3 C2H2-type zinc-finger domain zf-Di19 PF05605.10 NM_172385.2_3 - 1.8e-06 28.0 49.5 0.0094 16.1 1.9 7.7 6 3 1 7 7 7 4 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.9 NM_172385.2_3 - 0.0039 16.8 11.3 0.74 9.5 0.1 5.7 5 2 2 7 7 7 1 GAGA factor CpXC PF14353.4 NM_172385.2_3 - 0.01 15.7 23.1 8 6.4 0.3 6.8 4 3 2 6 6 6 0 CpXC protein zf-C2H2_2 PF12756.5 NM_172385.2_3 - 0.027 14.7 40.9 6.5 7.0 6.5 9.8 5 3 4 9 9 9 0 C2H2 type zinc-finger (2 copies) TerY_C PF15616.4 NM_172385.2_3 - 0.055 13.5 3.5 9.5 6.2 0.0 3.3 3 0 0 3 3 3 0 TerY-C metal binding domain DUF3268 PF11672.6 NM_172385.2_3 - 0.18 12.0 16.2 0.036 14.3 1.2 3.6 4 0 0 4 4 3 0 zinc-finger-containing domain Zn-ribbon_8 PF09723.8 NM_172385.2_3 - 0.19 11.8 35.7 0.94 9.5 3.8 6.1 5 1 0 5 5 5 0 Zinc ribbon domain DZR PF12773.5 NM_172385.2_3 - 0.74 9.8 22.5 0.12 12.2 0.4 5.4 5 1 0 5 5 5 0 Double zinc ribbon Actin_micro PF17003.3 NM_172385.2_3 - 0.87 8.6 19.5 17 4.3 7.5 5.3 4 1 1 5 5 5 0 Putative actin-like family zf-C2HE PF16278.3 NM_172385.2_3 - 3 8.3 42.5 0.59 10.5 0.3 7.7 6 3 1 7 7 6 0 C2HE / C2H2 / C2HC zinc-binding finger ARS2 PF04959.11 NM_172385.2_3 - 8.6 6.5 13.3 9.9 6.3 0.0 4.4 3 1 1 4 4 4 0 Arsenite-resistance protein 2 COesterase PF00135.26 NM_145603.2_3 - 1.8e-168 561.5 0.0 2.1e-168 561.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 NM_145603.2_3 - 1.8e-08 34.4 0.4 8.8e-08 32.1 0.4 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_145603.2_3 - 3e-05 23.5 0.1 5.3e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family BTB PF00651.29 NM_028603.4_1 - 6.9e-27 93.7 0.2 1.2e-26 93.0 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 NM_028603.4_1 - 3.6e-08 33.4 2.3 3.6e-08 33.4 2.3 3.9 3 0 0 3 3 3 1 Zinc-finger double domain DUF3342 PF11822.6 NM_028603.4_1 - 4e-06 26.8 0.1 9e-06 25.7 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-H2C2_5 PF13909.4 NM_028603.4_1 - 9.2e-05 22.0 2.9 0.00036 20.1 2.9 2.1 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 NM_028603.4_1 - 0.00015 21.9 23.1 0.00045 20.4 2.1 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_028603.4_1 - 0.00066 20.2 17.8 0.006 17.2 1.8 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger BTB_2 PF02214.20 NM_028603.4_1 - 0.0024 18.0 0.1 0.0043 17.2 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain zinc_ribbon_10 PF10058.7 NM_028603.4_1 - 0.044 13.4 4.6 7.3 6.3 0.0 3.2 2 1 1 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-met PF12874.5 NM_028603.4_1 - 0.047 14.0 3.4 0.21 11.9 0.3 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 NM_028603.4_1 - 6.1 6.9 9.5 0.36 10.8 1.0 2.8 2 1 0 2 2 2 0 Zinc ribbon domain zf-Di19 PF05605.10 NM_028603.4_1 - 6.6 7.0 12.1 0.97 9.6 6.4 2.5 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Xpo1 PF08389.10 NM_001081056.1_2 - 2.9e-41 140.8 1.1 2.9e-41 140.8 1.1 3.5 4 0 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.17 NM_001081056.1_2 - 3.7e-06 26.6 0.6 1.2e-05 25.0 0.6 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain DUF310 PF03750.11 NM_001081056.1_2 - 0.078 13.7 0.8 1.2 9.9 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF310) ELO PF01151.16 NM_134255.3_3 - 1e-64 218.4 23.8 1.5e-64 217.8 23.8 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family Pkinase PF00069.23 NM_001310448.1_1 - 6.2e-67 225.6 0.0 8.1e-67 225.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001310448.1_1 - 3.2e-31 108.4 0.0 4.7e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001310448.1_1 - 0.013 14.7 0.0 0.025 13.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Lipocalin PF00061.21 NM_011255.3_1 - 1.1e-18 67.7 0.0 1.6e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 NM_011255.3_1 - 8.8e-06 25.6 0.0 1.4e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.11 NM_011255.3_1 - 0.089 12.5 0.2 0.24 11.1 0.2 1.8 1 1 0 1 1 1 0 Triabin zf-C2H2 PF00096.24 NM_001033299.3_3 - 2e-16 59.3 59.5 0.00016 21.8 1.1 10.0 10 0 0 10 10 10 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001033299.3_3 - 3.2e-15 55.4 57.1 0.006 17.2 0.7 10.1 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_001033299.3_3 - 2.2e-07 30.9 0.3 2.2e-07 30.9 0.3 11.3 12 0 0 12 12 12 3 Zinc-finger double domain zf-H2C2_5 PF13909.4 NM_001033299.3_3 - 7.8e-05 22.2 3.1 7.8e-05 22.2 3.1 8.4 10 1 0 10 10 10 2 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.5 NM_001033299.3_3 - 0.00013 22.1 0.1 0.00013 22.1 0.1 5.9 4 2 2 6 6 6 2 C2H2 type zinc-finger (2 copies) GAGA PF09237.9 NM_001033299.3_3 - 0.098 12.3 5.4 1.8 8.3 0.2 4.2 3 1 1 4 4 4 0 GAGA factor zinc_ribbon_15 PF17032.3 NM_001033299.3_3 - 0.22 12.1 8.4 3.4 8.3 0.1 4.5 4 0 0 4 4 4 0 zinc-ribbon family zf-C2H2_8 PF15909.3 NM_001033299.3_3 - 2.3 8.4 22.3 4.5 7.5 0.3 5.7 4 1 2 6 6 6 0 C2H2-type zinc ribbon PKI PF02827.14 NM_008862.3_3 - 4.4e-27 94.0 0.8 6.9e-27 93.3 0.8 1.3 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor EF1_GNE PF00736.17 NM_018796.3_1 - 9.2e-37 125.0 0.6 1.5e-36 124.3 0.6 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 NM_018796.3_1 - 1.5e-12 47.6 9.7 2.9e-12 46.6 9.7 1.5 1 0 0 1 1 1 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.4 NM_018796.3_1 - 0.091 12.8 0.2 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 NM_018796.3_1 - 0.11 12.2 0.0 0.3 10.8 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Allantoicase PF03561.13 NM_053156.2_1 - 1e-88 294.5 0.0 4.4e-49 166.0 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat Spt4 PF06093.11 NM_011509.2_1 - 1e-30 105.5 0.4 1.3e-30 105.1 0.4 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Sacchrp_dh_NADP PF03435.16 NM_178653.3_3 - 2.8e-25 88.9 0.0 4.1e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain LVIVD PF08309.9 NM_178653.3_3 - 0.11 11.6 0.1 0.31 10.3 0.1 1.7 1 0 0 1 1 1 0 LVIVD repeat TUTF7_u4 PF16631.3 NM_153538.3_3 - 1.7e-38 130.9 19.5 1.7e-38 130.9 19.5 2.9 2 0 0 2 2 2 1 Unstructured region 4 on terminal uridylyltransferase 7 PAP_assoc PF03828.17 NM_153538.3_3 - 8e-28 96.3 0.2 4.1e-14 52.4 0.1 2.9 2 0 0 2 2 2 2 Cid1 family poly A polymerase zf-CCHC PF00098.21 NM_153538.3_3 - 8.1e-14 50.8 19.6 3.9e-05 23.4 2.3 4.1 3 0 0 3 3 3 3 Zinc knuckle NTP_transf_2 PF01909.21 NM_153538.3_3 - 2.1e-06 27.8 0.0 1.1e-05 25.5 0.0 2.2 2 0 0 2 2 2 1 Nucleotidyltransferase domain zf-CCHC_4 PF14392.4 NM_153538.3_3 - 4.5e-05 22.9 15.4 0.0098 15.4 0.7 3.7 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.4 NM_153538.3_3 - 4.9e-05 22.9 28.0 0.018 14.7 5.9 4.6 4 0 0 4 4 4 2 Zinc knuckle tRNA_NucTransf2 PF09249.9 NM_153538.3_3 - 0.0024 18.0 0.0 3 8.0 0.0 2.6 2 0 0 2 2 2 2 tRNA nucleotidyltransferase, second domain zf-C2H2_2 PF12756.5 NM_153538.3_3 - 0.27 11.5 5.6 0.43 10.8 1.4 3.0 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) RAMP4 PF06624.10 NM_153538.3_3 - 0.29 11.1 3.7 2 8.4 0.0 3.2 3 0 0 3 3 3 0 Ribosome associated membrane protein RAMP4 AF-4 PF05110.11 NM_133919.4_3 - 0 1432.6 104.8 0 1432.4 104.8 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein DUF2603 PF10788.7 NM_001286003.1_2 - 0.17 11.7 0.5 0.28 11.0 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2603) NGF PF00243.16 NM_008742.3_2 - 3.1e-51 172.2 3.4 4.5e-51 171.7 3.4 1.2 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.3 NM_008742.3_2 - 0.0012 19.2 0.5 0.002 18.4 0.5 1.4 1 0 0 1 1 1 1 Spaetzle HPS3_C PF14763.4 NM_001146323.1_1 - 9.4e-172 571.1 2.2 1.4e-171 570.5 2.2 1.3 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3, C-terminal HPS3_Mid PF14762.4 NM_001146323.1_1 - 1e-163 544.5 5.4 1e-163 544.5 5.4 2.0 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3, middle region HPS3_N PF14761.4 NM_001146323.1_1 - 1.4e-18 67.2 0.0 2.6e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3 Nucleoporin_N PF08801.9 NM_133227.3_2 - 2e-104 349.6 0.0 2.7e-104 349.2 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.12 NM_133227.3_2 - 1e-19 70.6 8.3 1.5e-19 70.0 8.3 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal BPS PF08947.8 NM_001177629.1_1 - 1e-27 95.6 0.5 1.8e-27 94.8 0.5 1.4 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 NM_001177629.1_1 - 1.5e-13 50.4 0.0 2.9e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 NM_001177629.1_1 - 1.6e-10 41.4 1.4 2.5e-10 40.7 0.2 2.0 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 NM_001177629.1_1 - 2.1e-08 34.5 0.1 4e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 PH domain UDPGT PF00201.16 NM_201642.4_1 - 7.7e-232 770.3 0.0 9.3e-232 770.1 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 NM_201642.4_1 - 8.4e-07 29.0 0.0 1.6e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain LRR_8 PF13855.4 NM_133212.3_3 - 1.2e-68 226.6 107.1 4e-09 36.0 6.1 14.5 8 4 6 14 14 14 14 Leucine rich repeat LRR_4 PF12799.5 NM_133212.3_3 - 7.4e-33 111.8 100.8 0.0003 21.0 0.9 15.3 7 4 11 18 18 18 17 Leucine Rich repeats (2 copies) TIR PF01582.18 NM_133212.3_3 - 3.3e-14 52.9 0.7 7.3e-14 51.8 0.7 1.5 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 NM_133212.3_3 - 5.2e-06 26.6 0.1 9.7e-06 25.7 0.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 NM_133212.3_3 - 0.00055 19.9 94.1 0.49 10.9 1.1 21.2 21 3 0 21 21 21 3 Leucine Rich Repeat MPC PF03650.11 NM_018819.4_1 - 2.6e-33 114.3 0.0 4.3e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) SR-25 PF10500.7 NM_153782.1_1 - 3.7 7.0 25.9 5.4 6.4 25.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Fam20C PF06702.10 NM_153782.1_2 - 3.5e-99 330.9 0.0 5.7e-99 330.2 0.0 1.3 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.4 NM_153782.1_2 - 0.0025 16.7 0.0 0.0052 15.6 0.0 1.4 1 0 0 1 1 1 1 FAM198 protein DUF4604 PF15377.4 NM_153782.1_2 - 0.22 11.8 13.3 0.43 10.9 13.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF1442 PF07279.9 NM_001286448.1_2 - 0.19 10.9 0.2 0.29 10.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1442) Reticulon PF02453.15 NM_001286448.1_3 - 4.1e-44 150.2 9.8 6.1e-44 149.6 9.8 1.3 1 0 0 1 1 1 1 Reticulon Actin PF00022.17 NM_019785.2_3 - 6.8e-48 163.1 0.0 3.5e-46 157.5 0.0 2.2 1 1 0 1 1 1 1 Actin NAC PF01849.16 NM_013608.3_2 - 1e-24 86.1 0.9 2.2e-24 85.1 0.3 1.9 2 0 0 2 2 2 1 NAC domain RNA_pol_Rpo13 PF12136.6 NM_013608.3_2 - 0.094 12.5 3.9 0.23 11.3 3.9 1.6 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain SPRR2 PF14820.4 NM_001309382.1_2 - 1.5e-09 37.9 61.3 1.2e-06 28.7 39.0 2.4 1 1 1 2 2 2 2 Small proline-rich 2 DUF1981 PF09324.8 NM_001033258.4_2 - 1.9e-12 46.7 0.8 2.8e-11 43.0 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) DCB PF16213.3 NM_001033258.4_2 - 1e-11 44.7 3.8 1e-11 44.7 3.8 2.1 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.5 NM_001033258.4_2 - 0.0047 16.8 1.2 0.0047 16.8 1.2 3.1 3 1 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal SWIRM-assoc_1 PF16495.3 NM_001033258.4_2 - 0.15 12.0 1.9 0.36 10.8 1.9 1.7 1 0 0 1 1 1 0 SWIRM-associated region 1 Orn_Arg_deC_N PF02784.14 NM_172875.4_3 - 5.1e-68 229.0 0.0 6.5e-68 228.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 NM_172875.4_3 - 4.9e-19 68.3 0.0 8.7e-19 67.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 NM_172875.4_3 - 0.00024 20.4 0.0 0.00049 19.5 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF4636 PF15468.4 NM_027073.1_3 - 5.7e-95 317.5 15.3 7e-95 317.2 15.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4636) CDV3 PF15359.4 NM_027073.1_3 - 9.9 6.5 13.0 2.2 8.6 2.4 2.2 1 1 1 2 2 2 0 Carnitine deficiency-associated protein 3 HIT PF01230.21 NM_008248.2_2 - 1.3e-30 105.8 0.0 1.7e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.6 NM_008248.2_2 - 2.4e-22 79.4 0.0 3e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Abhydrolase_1 PF00561.18 NM_001111100.1_2 - 1.3e-28 100.2 0.5 1.6e-28 99.9 0.5 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.14 NM_001111100.1_2 - 1.5e-24 85.2 0.0 3.3e-24 84.1 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.6 NM_001111100.1_2 - 9.8e-05 21.6 0.0 0.0018 17.5 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.5 NM_001111100.1_2 - 0.099 13.1 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF900 PF05990.10 NM_001111100.1_2 - 0.21 11.0 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DAD PF02109.14 NM_001113358.1_1 - 6.1e-47 158.3 1.7 8.6e-47 157.8 1.7 1.2 1 0 0 1 1 1 1 DAD family 7tm_4 PF13853.4 NM_001011847.1_1 - 2.8e-104 348.7 17.9 3.2e-104 348.4 17.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011847.1_1 - 7.9e-21 74.4 19.7 2e-20 73.0 19.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011847.1_1 - 2.8e-07 30.0 12.0 5e-07 29.2 11.7 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_001162940.1_1 - 7.8e-56 189.7 16.0 9.2e-56 189.5 16.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001162940.1_1 - 1.1e-25 90.3 23.2 2.7e-25 89.0 23.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001162940.1_1 - 1.5e-06 27.6 18.9 4e-06 26.3 18.9 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4577 PF15145.4 NM_001162940.1_1 - 0.028 14.3 0.2 0.028 14.3 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) ANF_receptor PF01094.26 NM_008165.4_3 - 2.6e-70 237.1 0.1 2.8e-69 233.8 0.0 2.1 2 0 0 2 2 2 1 Receptor family ligand binding region Lig_chan PF00060.24 NM_008165.4_3 - 4.9e-59 198.3 0.1 7.8e-59 197.6 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_008165.4_3 - 5.2e-44 149.0 0.0 1e-43 148.0 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_008165.4_3 - 4e-23 81.9 0.0 7.4e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF659 PF04937.13 NM_008165.4_3 - 0.16 11.6 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) Atrophin-1 PF03154.13 NM_008165.4_3 - 4.4 5.3 24.8 6 4.9 24.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF1777 PF08648.10 NM_008165.4_3 - 7.9 6.6 20.4 13 5.9 20.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) Sds3 PF08598.9 NM_134155.1_2 - 9.8e-20 71.4 1.3 9.8e-20 71.4 1.3 2.1 2 1 0 2 2 2 1 Sds3-like Vps55 PF04133.12 NM_175036.4_1 - 2.2e-38 130.7 4.9 3.8e-38 129.9 4.9 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Glypican PF01153.17 NM_011821.3_1 - 9.1e-249 826.8 0.7 1.3e-248 826.3 0.7 1.1 1 0 0 1 1 1 1 Glypican SPX PF03105.17 NM_011821.3_2 - 2.7 7.7 20.3 4.2 7.1 20.3 1.1 1 0 0 1 1 1 0 SPX domain UBA PF00627.29 NM_001290492.1_1 - 1.5e-05 24.7 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Rhomboid PF01694.20 NM_001290492.1_1 - 5.8e-05 23.0 8.9 0.0001 22.2 8.9 1.4 1 0 0 1 1 1 1 Rhomboid family HEAT PF02985.20 NM_001305882.1_2 - 2.7e-07 30.1 1.5 0.11 12.6 0.0 4.0 4 0 0 4 4 4 3 HEAT repeat HEAT_EZ PF13513.4 NM_001305882.1_2 - 0.0033 17.7 0.1 2.5 8.5 0.0 2.7 3 0 0 3 3 3 2 HEAT-like repeat Cnd1 PF12717.5 NM_001305882.1_2 - 0.14 12.0 0.0 0.53 10.1 0.0 1.8 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 TGF_beta_GS PF08515.10 NM_172414.4_1 - 8.7 5.8 8.1 0.34 10.3 1.2 2.1 2 0 0 2 2 2 0 Transforming growth factor beta type I GS-motif zf-C2HC_2 PF13913.4 NM_172414.4_2 - 2.2e-15 56.0 11.7 1.3e-07 31.2 4.2 2.6 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.4 NM_172414.4_2 - 0.04 14.6 5.8 1.6 9.6 0.6 3.3 2 0 0 2 2 2 0 C2H2-type zinc finger FYVE PF01363.19 NM_172414.4_2 - 0.052 13.6 2.0 0.36 10.9 0.0 2.9 2 0 0 2 2 2 0 FYVE zinc finger DUF3776 PF12618.6 NM_172414.4_2 - 0.081 13.3 0.9 0.21 12.0 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3776) zf-RING_7 PF02591.13 NM_172414.4_2 - 0.21 11.7 1.9 26 5.0 0.1 3.4 3 0 0 3 3 3 0 C4-type zinc ribbon domain OmpH PF03938.12 NM_172414.4_2 - 0.86 9.5 7.5 1.5 8.7 7.5 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Orai-1 PF07856.10 NM_198424.3_1 - 4.8e-67 224.9 2.5 8.8e-67 224.1 2.5 1.4 1 1 0 1 1 1 1 Mediator of CRAC channel activity Apc13p PF05839.9 NM_181394.3_1 - 1.5e-18 66.6 0.3 2.4e-18 66.0 0.3 1.3 1 0 0 1 1 1 1 Apc13p protein FYVE_2 PF02318.14 NM_001039365.2_2 - 9.3e-10 38.6 5.7 1.6e-09 37.9 5.7 1.3 1 0 0 1 1 1 1 FYVE-type zinc finger DUF3725 PF12523.6 NM_001039365.2_2 - 0.52 10.5 2.6 0.36 11.0 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3725) Sema PF01403.17 NM_013658.3_1 - 2.2e-134 448.3 0.0 2.6e-134 448.1 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 NM_013658.3_1 - 1.9e-06 28.2 7.3 1.9e-06 28.2 7.3 2.5 2 0 0 2 2 2 1 Plexin repeat LEM PF03020.13 NM_013658.3_2 - 0.17 11.3 0.0 0.34 10.4 0.0 1.5 1 0 0 1 1 1 0 LEM domain CDK5_activator PF03261.13 NM_009871.2_2 - 2.1e-100 336.7 11.6 1.8e-96 323.7 0.7 2.1 1 1 1 2 2 2 2 Cyclin-dependent kinase 5 activator protein MTBP_C PF14920.4 NM_009871.2_2 - 0.77 9.3 4.9 1.2 8.7 4.9 1.1 1 0 0 1 1 1 0 MDM2-binding DUF4710 PF15828.3 NM_009871.2_3 - 6.3 6.9 11.6 1.6 8.8 1.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Arm PF00514.21 NM_001165902.1_1 - 4.4e-41 137.6 19.5 1.3e-07 31.2 0.1 11.9 13 0 0 13 13 13 7 Armadillo/beta-catenin-like repeat Cnd1 PF12717.5 NM_001165902.1_1 - 1.6e-08 34.6 1.8 0.0054 16.6 0.3 4.3 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 NM_001165902.1_1 - 3.9e-06 27.0 4.8 0.04 14.2 0.2 4.8 5 0 0 5 5 5 1 HEAT repeats HEAT_EZ PF13513.4 NM_001165902.1_1 - 6.1e-06 26.4 6.9 1.6 9.1 0.0 6.2 5 1 1 6 6 6 2 HEAT-like repeat Adaptin_N PF01602.18 NM_001165902.1_1 - 8e-06 24.5 2.5 0.0014 17.1 1.1 3.0 3 0 0 3 3 3 1 Adaptin N terminal region HEAT PF02985.20 NM_001165902.1_1 - 8.4e-06 25.5 1.5 24 5.4 0.0 5.9 5 0 0 5 5 5 0 HEAT repeat Atx10homo_assoc PF09759.7 NM_001165902.1_1 - 0.0017 18.3 0.9 0.017 15.1 0.2 3.0 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain RasGEF_N_2 PF14663.4 NM_001165902.1_1 - 0.0031 17.7 3.8 7.9 6.7 0.0 4.7 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF3361 PF11841.6 NM_001165902.1_1 - 0.0032 17.3 2.0 2.8 7.8 0.0 4.4 2 1 1 5 5 5 1 Domain of unknown function (DUF3361) Queuosine_synth PF02547.13 NM_001165902.1_1 - 0.034 13.1 0.6 0.055 12.4 0.1 1.5 2 0 0 2 2 2 0 Queuosine biosynthesis protein Arm_2 PF04826.11 NM_001165902.1_1 - 0.041 13.2 3.3 1.1 8.6 0.0 3.3 2 1 1 3 3 3 0 Armadillo-like Myelin_PLP PF01275.17 NM_001177962.1_2 - 1.9e-100 335.4 20.7 2.5e-100 335.1 20.7 1.1 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) NID PF07292.11 NM_001141948.1_1 - 3.1e-62 207.1 4.1 4.7e-30 104.0 0.3 3.0 3 0 0 3 3 3 2 Nmi/IFP 35 domain (NID) IFP_35_N PF07334.11 NM_001141948.1_1 - 5.1e-38 128.9 5.7 1.8e-37 127.1 4.3 2.2 2 0 0 2 2 2 1 Interferon-induced 35 kDa protein (IFP 35) N-terminus Seryl_tRNA_N PF02403.20 NM_001141948.1_1 - 0.094 12.8 3.7 0.18 11.9 3.7 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain M PF02370.14 NM_001141948.1_1 - 0.73 10.5 3.5 2.2 9.0 3.5 1.8 1 0 0 1 1 1 0 M protein repeat MFS_1 PF07690.14 NM_001313747.1_2 - 2.6e-07 29.8 8.5 2.6e-07 29.8 8.5 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2375 PF09558.8 NM_001313747.1_3 - 0.085 12.8 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2375) Hormone_1 PF00103.18 NM_008865.3_3 - 4.3e-53 180.1 0.2 5.7e-53 179.7 0.2 1.1 1 0 0 1 1 1 1 Somatotropin hormone family GBP PF02263.17 NM_001163505.1_1 - 3.1e-95 318.2 0.1 4.4e-95 317.7 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 NM_001163505.1_1 - 4.7e-06 26.1 0.2 6.9e-06 25.5 0.2 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain IRK PF01007.18 NM_010605.4_2 - 2.2e-143 477.1 1.3 3.1e-143 476.6 1.3 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_010605.4_2 - 0.014 15.2 6.0 0.043 13.7 6.0 1.9 1 0 0 1 1 1 0 Ion channel IBN_N PF03810.17 NM_023146.2_2 - 2.8e-11 43.0 0.8 1.4e-10 40.8 0.2 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Trypsin PF00089.24 NM_199471.1_1 - 2.1e-54 184.5 0.2 2.9e-54 184.1 0.2 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_199471.1_1 - 0.00059 20.1 0.2 0.0012 19.1 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_199471.1_1 - 0.0074 17.0 0.0 0.015 16.0 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.13 NM_199471.1_1 - 0.012 15.1 0.2 0.84 9.0 0.2 2.6 1 1 1 2 2 2 0 Chymotrypsin family Peptidase-S1 MHC_I PF00129.16 NM_008204.2_1 - 4.5e-74 247.7 2.3 6.3e-74 247.3 2.3 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_008204.2_1 - 6.1e-14 52.1 0.1 1.9e-13 50.5 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin C1-set domain ig PF00047.23 NM_008204.2_1 - 0.00011 22.1 0.0 0.00037 20.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Yae1_N PF09811.7 NM_008204.2_1 - 0.11 12.0 3.2 0.28 10.8 3.2 1.7 1 0 0 1 1 1 0 Essential protein Yae1, N terminal FOXP-CC PF16159.3 NM_008204.2_1 - 7.9 7.1 6.6 17 6.0 0.3 2.4 2 0 0 2 2 2 0 FOXP coiled-coil domain Yae1_N PF09811.7 NM_008204.2_2 - 0.099 12.2 1.3 0.18 11.4 1.3 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Cu_amine_oxid PF01179.18 NM_001081273.2_2 - 1.6e-90 303.8 5.8 2.2e-90 303.4 5.8 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.14 NM_001081273.2_2 - 2.4e-22 78.8 0.0 4.2e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.14 NM_001081273.2_2 - 3.4e-13 49.7 0.0 9.1e-13 48.4 0.0 1.8 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain DUF1965 PF09248.8 NM_001081273.2_2 - 9.1e-05 22.0 0.0 0.00022 20.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Fcf2 PF08698.9 NM_153806.1_3 - 2.1e-37 127.3 0.4 2.1e-37 127.3 0.4 3.0 3 1 2 5 5 5 1 Fcf2 pre-rRNA processing HMG_CoA_synt_C PF08540.8 NM_008256.4_3 - 2.1e-127 424.4 1.0 2.6e-127 424.1 1.0 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.15 NM_008256.4_3 - 6.2e-108 358.2 0.1 8.4e-108 357.8 0.1 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III PF08545.8 NM_008256.4_3 - 0.03 14.1 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Dysbindin PF04440.14 NM_001048228.1_2 - 5.4e-29 101.1 1.5 8.2e-29 100.5 1.5 1.2 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) 7tm_1 PF00001.19 NM_153524.2_2 - 2.1e-14 53.3 32.9 8.6e-07 28.3 20.7 3.1 2 1 1 3 3 3 3 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 NM_153524.2_2 - 8.1e-05 21.9 21.5 8.1e-05 21.9 21.5 2.5 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx EPO_TPO PF00758.16 NM_009379.3_2 - 3.8e-45 153.6 0.1 6.7e-45 152.8 0.1 1.4 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin PEHE PF15275.4 NM_028722.2_3 - 3.8e-27 95.3 0.5 3.8e-27 95.3 0.5 2.8 3 0 0 3 3 3 1 PEHE domain MSL1_dimer PF16801.3 NM_028722.2_3 - 2.1e-18 65.6 14.7 4.4e-18 64.6 14.7 1.6 1 0 0 1 1 1 1 Dimerisation domain of Male-specific-Lethal 1 Herpes_UL6 PF01763.14 NM_028722.2_3 - 0.077 11.4 1.1 0.11 10.8 1.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like ALO PF04030.12 NM_178747.3_2 - 6.3e-89 298.1 3.8 9.2e-89 297.6 3.8 1.2 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.21 NM_178747.3_2 - 2.9e-33 114.4 1.5 4.1e-33 113.9 1.5 1.2 1 0 0 1 1 1 1 FAD binding domain FKBP_C PF00254.26 NM_016666.3_1 - 9.2e-09 35.4 0.0 1.8e-08 34.4 0.0 1.5 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.15 NM_016666.3_1 - 3.4e-05 23.5 3.5 0.0019 18.1 0.4 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_016666.3_1 - 0.24 11.6 1.4 0.36 11.0 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat YfiO PF13525.4 NM_016666.3_1 - 0.52 9.9 2.1 8 6.0 0.2 2.1 1 1 0 2 2 2 0 Outer membrane lipoprotein TPR_11 PF13414.4 NM_016666.3_1 - 1.2 8.7 7.9 6.7 6.4 1.3 2.9 3 0 0 3 3 3 0 TPR repeat Xpo1 PF08389.10 NM_177296.4_3 - 4.5e-28 98.1 5.8 1.4e-26 93.2 0.7 3.9 3 1 1 4 4 4 2 Exportin 1-like protein IFRD PF05004.11 NM_177296.4_3 - 0.017 14.1 0.4 1.4 7.8 0.0 2.7 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.5 NM_177296.4_3 - 0.1 13.1 0.0 40 4.7 0.0 3.5 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region HEAT PF02985.20 NM_177296.4_3 - 0.97 9.7 5.8 1.5e+02 2.9 0.0 5.8 6 0 0 6 6 6 0 HEAT repeat KH_1 PF00013.27 NM_031397.2_1 - 1e-38 130.8 4.5 1.3e-15 56.8 0.3 5.5 5 0 0 5 5 5 4 KH domain SAM_1 PF00536.28 NM_031397.2_1 - 3.2e-14 53.0 0.1 6.1e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_031397.2_1 - 4.9e-11 42.5 0.1 9.9e-11 41.5 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) KH_2 PF07650.15 NM_031397.2_1 - 0.0064 16.2 0.0 0.75 9.5 0.0 2.6 2 0 0 2 2 2 1 KH domain EGF_alliinase PF04863.11 NM_031397.2_1 - 0.04 14.1 0.3 0.1 12.8 0.3 1.7 1 0 0 1 1 1 0 Alliinase EGF-like domain IGR PF09597.8 NM_031397.2_1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 IGR protein motif Cadherin PF00028.15 NM_181564.2_3 - 3.5e-58 193.9 0.0 4.1e-18 65.5 0.0 5.2 5 0 0 5 5 5 4 Cadherin domain Cadherin_C PF01049.15 NM_181564.2_3 - 3.2e-06 27.3 0.0 8.1e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 NM_181564.2_3 - 0.00045 20.1 0.2 0.012 15.5 0.1 2.7 2 0 0 2 2 2 1 Cadherin-like zf-RING_UBOX PF13445.4 NM_001164220.1_2 - 8.5e-11 41.6 10.0 8.5e-11 41.6 10.0 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_001164220.1_2 - 1.3e-07 31.2 8.9 1.3e-07 31.2 8.9 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 NM_001164220.1_2 - 1.3e-07 31.5 0.2 1.3e-07 31.5 0.2 2.9 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_3 PF13920.4 NM_001164220.1_2 - 2.9e-07 30.1 6.4 2.9e-07 30.1 6.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001164220.1_2 - 6.3e-07 29.1 8.1 6.3e-07 29.1 8.1 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_001164220.1_2 - 2.2e-06 27.7 10.4 2.2e-06 27.7 10.4 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.4 NM_001164220.1_2 - 4.9e-06 26.5 10.6 4.9e-06 26.5 10.6 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 NM_001164220.1_2 - 0.00018 21.2 13.2 0.00018 21.2 13.2 2.8 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.4 NM_001164220.1_2 - 0.035 13.7 6.4 0.13 11.9 6.5 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain ATP-synt_E_2 PF08112.9 NM_001164220.1_2 - 0.14 12.3 3.2 0.25 11.5 0.5 2.4 2 0 0 2 2 2 0 ATP synthase epsilon subunit Prok-RING_4 PF14447.4 NM_001164220.1_2 - 0.2 11.4 16.0 0.054 13.2 11.0 2.6 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 RecG_N PF17190.2 NM_001164220.1_2 - 0.31 11.6 4.0 4 8.1 2.3 2.9 2 1 0 2 2 2 0 RecG N-terminal helical domain zf-Nse PF11789.6 NM_001164220.1_2 - 0.47 10.2 4.2 0.95 9.2 4.2 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.3 NM_001164220.1_2 - 8.8 6.4 13.5 0.86 9.6 8.4 2.0 1 1 1 2 2 2 0 zinc RING finger of MSL2 AIG1 PF04548.14 NM_175048.3_1 - 6.7e-12 45.0 5.8 5.7e-07 29.0 0.4 2.2 1 1 1 2 2 2 2 AIG1 family Motilin_assoc PF04643.10 NM_001286404.1_2 - 1.4e-33 114.4 0.3 2.1e-33 113.8 0.3 1.3 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide Motilin_ghrelin PF04644.10 NM_001286404.1_2 - 4.8e-11 42.2 3.6 7.6e-11 41.5 3.6 1.3 1 0 0 1 1 1 1 Motilin/ghrelin Histone PF00125.22 NM_178198.2_1 - 6e-26 91.3 0.7 8.7e-26 90.8 0.7 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_178198.2_1 - 8e-07 29.1 1.0 1.1e-06 28.6 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 NM_178198.2_1 - 0.0013 19.0 0.0 0.0024 18.2 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.3 NM_178198.2_1 - 0.0026 17.7 0.3 0.0033 17.4 0.3 1.2 1 0 0 1 1 1 1 YscO-like protein Yae1_N PF09811.7 NM_178198.2_3 - 0.17 11.5 4.1 0.42 10.2 4.1 1.7 1 0 0 1 1 1 0 Essential protein Yae1, N terminal DARPP-32 PF05395.10 NM_001290744.1_2 - 3.4e-20 72.8 1.5 4.9e-20 72.2 1.5 1.2 1 0 0 1 1 1 1 Protein phosphatase inhibitor 1/DARPP-32 Cor1 PF04803.10 NM_001100610.2_1 - 6e-09 36.1 8.0 1.4e-08 34.9 8.0 1.5 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region WWE PF02825.18 NM_026518.4_2 - 1.3e-15 57.5 2.5 2.3e-15 56.8 2.5 1.4 1 0 0 1 1 1 1 WWE domain zf-C3HC4_3 PF13920.4 NM_026518.4_2 - 1.3e-06 28.0 10.7 4.5e-06 26.3 10.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_026518.4_2 - 0.00022 21.3 12.6 0.00065 19.8 12.6 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 NM_026518.4_2 - 0.00037 20.2 11.6 0.001 18.8 11.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_026518.4_2 - 0.00056 19.7 10.3 0.0023 17.7 10.3 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 NM_026518.4_2 - 0.0017 18.0 12.0 0.0042 16.8 12.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_026518.4_2 - 0.019 14.7 10.2 0.043 13.5 10.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.4 NM_026518.4_2 - 0.026 14.6 10.9 0.096 12.7 10.9 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 NM_026518.4_2 - 0.066 13.1 11.4 0.15 11.9 11.4 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_10 PF16685.3 NM_026518.4_2 - 0.14 12.2 7.5 0.34 11.0 7.5 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.3 NM_026518.4_2 - 4.8 6.8 10.8 17 5.1 10.8 2.1 1 0 0 1 1 1 0 RING-like zinc finger UPAR_LY6 PF00021.19 NM_011837.3_2 - 1e-17 64.4 13.2 1e-17 64.4 13.2 1.6 2 0 0 2 2 2 1 u-PAR/Ly-6 domain Toxin_1 PF00087.19 NM_011837.3_2 - 0.039 14.1 15.5 0.17 12.0 15.5 2.1 1 1 0 1 1 1 0 Snake toxin STAT_bind PF02864.13 NM_009283.4_3 - 5.1e-79 265.5 0.4 5.1e-79 265.5 0.4 1.6 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 NM_009283.4_3 - 2.4e-53 180.5 19.3 2.4e-53 180.5 19.3 1.7 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 NM_009283.4_3 - 6.4e-39 133.1 8.0 6.4e-39 133.1 8.0 2.5 3 0 0 3 3 3 1 STAT protein, protein interaction domain STAT1_TAZ2bind PF12162.6 NM_009283.4_3 - 3.8e-14 51.8 0.6 7.1e-14 50.9 0.6 1.5 1 0 0 1 1 1 1 STAT1 TAZ2 binding domain SH2 PF00017.22 NM_009283.4_3 - 6.1e-09 35.7 0.0 2e-08 34.0 0.0 1.9 1 0 0 1 1 1 1 SH2 domain NPV_P10 PF05531.10 NM_009283.4_3 - 0.73 10.2 4.2 2.3 8.6 0.9 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3523 PF12037.6 NM_009283.4_3 - 2 7.6 9.8 3.3 6.9 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Sec20 PF03908.11 NM_009283.4_3 - 9 6.2 7.0 12 5.8 0.1 3.0 3 0 0 3 3 3 0 Sec20 DUF1049 PF06305.9 NM_001198794.1_2 - 0.14 11.9 0.3 0.27 11.0 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) HisKA_4TM PF16926.3 NM_001198794.1_2 - 0.17 11.3 0.1 0.3 10.5 0.1 1.3 1 0 0 1 1 1 0 Archaeal 4TM region of histidine kinase FERM_M PF00373.16 NM_013512.2_1 - 3.3e-21 75.8 0.1 8.4e-21 74.4 0.1 1.7 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.8 NM_013512.2_1 - 1.2e-19 69.9 0.8 4.4e-19 68.0 0.2 2.1 2 0 0 2 2 2 1 FERM N-terminal domain FERM_C PF09380.8 NM_013512.2_1 - 2.2e-17 63.1 0.4 4.6e-17 62.1 0.4 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.9 NM_013512.2_1 - 4.7e-12 45.7 2.1 4.7e-12 45.7 2.1 2.7 2 0 0 2 2 2 1 FERM adjacent (FA) ADAM_spacer1 PF05986.12 NM_029981.1_3 - 9.9e-26 89.9 0.1 1.7e-25 89.1 0.1 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.17 NM_029981.1_3 - 1.6e-24 85.7 99.3 1.7e-06 28.0 4.9 9.2 8 0 0 8 8 8 7 Thrombospondin type 1 domain PLAC PF08686.9 NM_029981.1_3 - 2.8e-10 40.6 7.7 1.4e-09 38.3 7.7 2.4 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Actin PF00022.17 NM_019673.2_2 - 4.1e-148 493.2 0.0 4.7e-148 493.0 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.11 NM_019673.2_2 - 0.0098 14.6 0.0 0.034 12.8 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein DAP PF15228.4 NM_146057.3_1 - 1.4e-29 102.9 7.0 2.4e-29 102.2 7.0 1.4 1 0 0 1 1 1 1 Death-associated protein Homeobox PF00046.27 NM_175686.3_2 - 5.6e-22 77.2 6.1 1.1e-21 76.3 6.1 1.5 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 NM_175686.3_2 - 1.5e-06 27.7 0.2 3.1e-06 26.7 0.2 1.6 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 NM_175686.3_2 - 0.0055 16.4 2.3 0.027 14.2 0.2 2.5 2 0 0 2 2 2 1 Homeobox KN domain A_deamin PF02137.16 NM_001024837.2_3 - 3.5e-113 378.2 0.0 4.5e-113 377.8 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 NM_001024837.2_3 - 2e-26 92.3 0.0 8.2e-13 48.7 0.0 2.6 2 0 0 2 2 2 2 Double-stranded RNA binding motif 7tm_4 PF13853.4 NM_207253.1_1 - 2.2e-47 162.0 14.6 2.7e-47 161.7 14.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207253.1_1 - 8.6e-20 70.9 15.7 1.6e-19 70.0 15.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_207253.1_1 - 0.0014 17.9 12.1 0.0025 17.1 12.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 NM_207253.1_1 - 0.0044 16.4 5.7 0.0076 15.7 5.7 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc DUF717 PF05338.10 NM_207253.1_1 - 0.024 14.6 0.1 0.047 13.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF717) AT_hook PF02178.17 NM_001166541.1_1 - 7.8 6.6 39.0 6.7 6.8 10.1 3.8 3 0 0 3 3 3 0 AT hook motif LRR_8 PF13855.4 NM_001172481.1_3 - 8.7e-34 115.0 14.3 1.1e-12 47.4 2.1 5.0 4 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.5 NM_001172481.1_3 - 4.6e-18 64.8 23.4 5.5e-05 23.3 0.1 7.4 3 2 4 8 8 8 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_001172481.1_3 - 2e-10 40.6 3.6 5e-06 26.4 0.1 3.9 3 1 0 3 3 3 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_001172481.1_3 - 2.3e-09 36.9 8.3 0.00013 21.4 0.1 2.5 2 1 0 2 2 2 2 Leucine-rich repeat LRRNT PF01462.16 NM_001172481.1_3 - 2.8e-07 29.9 10.8 6e-07 28.8 3.0 3.9 4 0 0 4 4 4 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 NM_001172481.1_3 - 0.0095 16.1 14.4 1.6 9.4 0.1 7.4 8 1 1 9 9 9 1 Leucine Rich Repeat LRR_6 PF13516.4 NM_001172481.1_3 - 1.6 8.8 12.1 19 5.5 0.0 5.8 8 0 0 8 8 8 0 Leucine Rich repeat 7tm_4 PF13853.4 NM_146955.1_1 - 3.2e-50 171.3 15.9 4.1e-50 170.9 15.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146955.1_1 - 3.3e-21 75.6 20.6 5.9e-21 74.8 20.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146955.1_1 - 1.2e-07 31.2 7.1 1.2e-07 31.2 7.1 1.8 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx SWIB PF02201.16 NM_001025373.2_1 - 0.0097 15.6 1.7 5 6.9 0.1 4.5 2 2 2 6 6 6 1 SWIB/MDM2 domain FCH PF00611.21 NM_001025373.2_1 - 0.022 14.9 5.5 25 5.1 0.0 5.0 5 0 0 5 5 5 0 Fes/CIP4, and EFC/F-BAR homology domain tRNA_bind_3 PF17176.2 NM_001025373.2_1 - 0.047 13.8 0.0 5.4 7.2 0.0 2.8 1 1 2 3 3 3 0 tRNA-binding domain zf-H2C2_2 PF13465.4 NM_001025373.2_1 - 6.4 7.3 6.4 1.4 9.3 1.8 2.3 2 0 0 2 2 2 0 Zinc-finger double domain Fer2_BFD PF04324.13 NM_001025373.2_1 - 8.2 6.7 8.3 2.6e+02 1.9 0.0 5.8 6 0 0 6 6 6 0 BFD-like [2Fe-2S] binding domain zf-H2C2_2 PF13465.4 NM_001025373.2_3 - 2.8e-79 258.1 112.9 2e-09 37.3 3.4 14.4 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001025373.2_3 - 1.7e-51 169.7 133.8 5.4e-06 26.4 3.6 14.9 15 0 0 15 15 15 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001025373.2_3 - 1.3e-25 87.7 108.7 0.0063 17.1 1.2 13.9 12 0 0 12 12 12 11 C2H2-type zinc finger KRAB PF01352.25 NM_001025373.2_3 - 4.5e-21 74.1 1.7 4.5e-21 74.1 1.7 1.7 2 0 0 2 2 2 1 KRAB box zf-C2H2_11 PF16622.3 NM_001025373.2_3 - 2.5e-13 49.4 89.9 0.0013 18.4 0.4 13.4 13 0 0 13 13 13 10 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 NM_001025373.2_3 - 0.00014 21.4 11.1 0.0015 18.1 1.1 15.2 13 4 0 13 13 13 4 C2H2-type zinc-finger domain DUF3850 PF12961.5 NM_001025373.2_3 - 0.00041 20.4 0.5 9 6.5 0.0 5.3 3 2 3 6 6 6 1 Domain of Unknown Function with PDB structure (DUF3850) UBX PF00789.18 NM_001285930.1_1 - 3.2e-09 36.7 0.0 5.2e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 UBX domain MNNL PF07657.11 NM_001285930.1_1 - 0.32 10.9 1.4 0.97 9.4 1.4 1.8 1 0 0 1 1 1 0 N terminus of Notch ligand Guanylate_kin PF00625.19 NM_008621.3_2 - 6.1e-64 214.9 0.2 1e-63 214.2 0.2 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 NM_008621.3_2 - 1.3e-19 70.2 0.7 3e-19 69.0 0.7 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_2 PF07653.15 NM_008621.3_2 - 5.2e-10 38.7 0.0 1e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_008621.3_2 - 9.1e-08 31.5 1.0 3.1e-07 29.7 1.0 1.9 1 1 0 1 1 1 1 SH3 domain PDZ_2 PF13180.4 NM_008621.3_2 - 0.0001 22.4 0.3 0.00027 21.1 0.1 1.8 2 0 0 2 2 2 1 PDZ domain SH3_9 PF14604.4 NM_008621.3_2 - 0.00085 19.0 0.0 0.0016 18.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF258 PF03193.14 NM_008621.3_2 - 0.015 15.1 0.0 0.067 13.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 IKI3 PF04762.10 NM_026079.3_1 - 0 1017.9 0.0 0 1017.6 0.0 1.1 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.5 NM_026079.3_1 - 1.5e-05 25.1 3.3 0.33 11.2 0.0 5.5 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain LRR_8 PF13855.4 NM_175522.3_2 - 1.1e-31 108.2 14.4 4.3e-14 51.9 1.9 3.3 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 NM_175522.3_2 - 3.9e-08 33.3 5.8 0.0027 17.9 0.9 3.5 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_175522.3_2 - 8.4e-08 32.1 0.0 1.7e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_175522.3_2 - 0.031 13.6 0.2 0.49 9.7 0.0 2.1 1 1 1 2 2 2 0 Leucine-rich repeat UQ_con PF00179.24 NM_001081661.1_3 - 2e-51 173.2 0.0 2.5e-51 172.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 NM_001081661.1_3 - 0.024 14.8 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 RWD domain Jagunal PF07086.10 NM_001243739.1_1 - 9.2e-45 152.9 10.1 1.2e-44 152.6 10.1 1.1 1 0 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis DUF3810 PF12725.5 NM_001243739.1_1 - 0.4 9.8 2.6 0.54 9.4 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Jagunal PF07086.10 NM_001243739.1_3 - 2.2e-13 50.6 0.5 3.5e-13 49.9 0.5 1.2 1 0 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis CCDC50_N PF15295.4 NM_001289436.1_2 - 1.8e-29 102.3 4.8 2.8e-29 101.7 4.8 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 50 N-terminus CCDC50_N PF15295.4 NM_001289436.1_3 - 5.2e-13 49.2 25.7 5.3e-09 36.2 12.9 2.2 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 50 N-terminus DUF1462 PF07315.9 NM_001289436.1_3 - 0.088 12.9 0.2 0.17 12.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) WAP PF00095.19 NM_001081957.1_1 - 4.4e-11 42.8 18.9 4.4e-11 42.8 18.9 1.7 2 0 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' PX PF00787.22 NM_178279.2_1 - 1.4e-18 66.8 0.0 4.5e-18 65.1 0.0 1.9 1 0 0 1 1 1 1 PX domain Pkinase PF00069.23 NM_178279.2_1 - 3.2e-09 36.4 0.0 5.9e-08 32.3 0.0 2.6 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_178279.2_1 - 1.3e-07 31.0 0.0 1.1e-05 24.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase WH2 PF02205.18 NM_178279.2_1 - 2.9e-07 30.0 0.2 8.7e-07 28.5 0.1 1.9 2 0 0 2 2 2 1 WH2 motif Rrn6 PF10214.7 NM_178279.2_1 - 0.01 14.2 2.8 0.014 13.7 2.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Kelch_1 PF01344.23 NM_001122830.1_3 - 1.6e-33 113.8 8.6 1.4e-07 30.9 0.5 5.9 5 1 0 5 5 5 5 Kelch motif Kelch_6 PF13964.4 NM_001122830.1_3 - 4e-29 99.8 0.2 1e-05 25.5 0.0 5.7 2 1 3 5 5 5 5 Kelch motif BACK PF07707.13 NM_001122830.1_3 - 1.7e-26 92.2 0.4 2.6e-26 91.6 0.4 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 NM_001122830.1_3 - 1.9e-15 56.5 0.4 0.0011 19.0 0.0 5.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_001122830.1_3 - 1.1e-13 50.4 0.2 0.0016 18.2 0.0 5.7 5 1 0 5 5 5 3 Kelch motif Kelch_4 PF13418.4 NM_001122830.1_3 - 1.2e-12 47.5 5.4 0.00058 19.6 0.0 6.2 5 1 1 6 6 6 3 Galactose oxidase, central domain BTB PF00651.29 NM_001122830.1_3 - 8.3e-11 42.0 0.0 1.5e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.4 NM_001122830.1_3 - 1.2e-07 31.4 6.5 0.64 9.9 0.1 5.4 5 0 0 5 5 5 4 Kelch motif GCV_H PF01597.17 NM_026572.3_3 - 4.3e-49 165.3 0.4 5.6e-49 165.0 0.4 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein AMMECR1 PF01871.15 NM_153515.4_2 - 8.8e-49 165.2 0.0 1.3e-48 164.7 0.0 1.2 1 0 0 1 1 1 1 AMMECR1 THEG PF14912.4 NM_199226.1_2 - 5.9e-43 145.0 22.2 6.2e-18 64.9 3.9 5.3 3 2 3 6 6 6 6 Testicular haploid expressed repeat Aa_trans PF01490.16 NM_001164799.1_1 - 2.2e-52 178.0 35.5 2.8e-52 177.7 35.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CD36 PF01130.19 NM_001205082.1_3 - 9.7e-153 508.9 0.5 1.2e-152 508.6 0.5 1.0 1 0 0 1 1 1 1 CD36 family DUF3068 PF11271.6 NM_001205082.1_3 - 0.013 14.7 2.7 0.076 12.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3068) F-box-like PF12937.5 NM_001042485.1_1 - 0.14 12.0 1.3 0.29 10.9 1.3 1.5 1 0 0 1 1 1 0 F-box-like Arrestin_N PF00339.27 NM_029799.1_2 - 3.7e-20 72.3 0.0 3.7e-20 72.3 0.0 3.6 3 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 NM_029799.1_2 - 2.5e-19 69.9 0.2 5e-18 65.7 0.1 3.2 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.8 NM_029799.1_2 - 0.0061 15.7 0.3 0.0061 15.7 0.3 3.1 1 1 2 3 3 3 2 Rgp1 SR-25 PF10500.7 NM_029799.1_3 - 0.064 12.7 31.5 0.1 12.0 31.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RNA_polI_A34 PF08208.9 NM_029799.1_3 - 0.39 10.7 33.4 0.5 10.3 33.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Rxt3 PF08642.8 NM_029799.1_3 - 4.2 8.0 6.8 5.8 7.6 6.8 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Eapp_C PF10238.7 NM_029799.1_3 - 7.1 6.6 11.3 10 6.0 11.3 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein UCH PF00443.27 NM_027804.4_3 - 1.8e-76 256.9 0.0 2.4e-76 256.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP19_linker PF16602.3 NM_027804.4_3 - 4.3e-58 195.0 7.9 4.3e-58 195.0 7.9 2.3 2 0 0 2 2 2 1 Linker region of USP19 deubiquitinase UCH_1 PF13423.4 NM_027804.4_3 - 2e-19 70.2 0.0 7.9e-09 35.4 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase CS PF04969.14 NM_027804.4_3 - 2e-17 63.8 0.0 4.2e-13 50.0 0.0 2.5 2 0 0 2 2 2 2 CS domain zf-MYND PF01753.16 NM_027804.4_3 - 2.3e-07 30.6 16.5 2.3e-07 30.6 16.5 3.1 5 0 0 5 5 5 1 MYND finger USP7_C2 PF14533.4 NM_027804.4_3 - 0.013 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal SSF PF00474.15 NM_001003915.2_1 - 9.1e-40 136.6 21.4 1.2e-39 136.2 21.4 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family Hamartin PF04388.10 NM_001289576.1_3 - 3.5e-288 958.1 0.0 3.5e-288 958.1 0.0 2.7 3 0 0 3 3 3 1 Hamartin protein zf-C2H2_assoc PF16606.3 NM_001289576.1_3 - 0.00048 20.2 0.9 0.0019 18.3 0.9 2.0 1 0 0 1 1 1 1 Unstructured conserved, between two C2H2-type zinc-fingers V-SNARE PF05008.13 NM_001293686.1_2 - 6.1e-25 87.3 0.5 1.1e-24 86.4 0.5 1.5 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.6 NM_001293686.1_2 - 1.4e-19 69.9 6.4 1.5e-19 69.9 5.1 1.8 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Exonuc_VII_L PF02601.13 NM_001293686.1_2 - 0.32 10.4 3.0 0.63 9.4 3.0 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_S46 PF10459.7 NM_001293686.1_2 - 1 7.8 2.7 1.4 7.3 2.7 1.0 1 0 0 1 1 1 0 Peptidase S46 Myelin_MBP PF01669.15 NM_001025256.2_1 - 8e-45 153.0 13.3 9.5e-44 149.5 13.3 2.7 1 1 0 1 1 1 1 Myelin basic protein zf-C2H2 PF00096.24 NM_147221.2_3 - 1.3e-13 50.5 24.7 0.0021 18.3 0.7 5.7 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_147221.2_3 - 5.3e-11 42.3 20.4 2.7e-05 24.3 0.8 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_147221.2_3 - 1.4e-06 28.5 23.8 0.0068 17.0 0.2 5.9 5 0 0 5 5 5 3 C2H2-type zinc finger FOXP-CC PF16159.3 NM_147221.2_3 - 8.2e-06 26.2 16.2 0.01 16.3 0.6 4.9 1 1 4 5 5 5 3 FOXP coiled-coil domain zf-C2H2_8 PF15909.3 NM_147221.2_3 - 0.00096 19.3 8.8 0.086 13.0 0.9 3.3 2 2 1 3 3 3 2 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.6 NM_147221.2_3 - 2.5 8.4 6.2 67 3.8 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_147221.2_3 - 3.2 7.7 5.4 2.5 8.0 0.2 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.5 NM_147221.2_3 - 4.2 7.7 8.5 3.2 8.1 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.3 NM_147221.2_3 - 6.7 6.7 11.9 18 5.3 0.1 4.0 1 1 4 5 5 5 0 Aberrant zinc-finger Myc_N PF01056.16 NM_001177353.1_3 - 4e-114 381.8 10.9 6e-114 381.2 10.9 1.3 1 0 0 1 1 1 1 Myc amino-terminal region Myc-LZ PF02344.13 NM_001177353.1_3 - 4.4e-16 58.5 8.1 1.2e-15 57.1 8.1 1.8 1 0 0 1 1 1 1 Myc leucine zipper domain HLH PF00010.24 NM_001177353.1_3 - 5.4e-14 51.8 9.7 7.4e-14 51.3 2.1 2.4 2 0 0 2 2 2 2 Helix-loop-helix DNA-binding domain RabGAP-TBC PF00566.16 NM_178650.3_2 - 3.3e-53 180.4 0.0 5e-53 179.8 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain IL1 PF00340.17 NM_153511.3_1 - 1.9e-12 46.8 0.0 4.3e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Interleukin-1 / 18 zf-RING_2 PF13639.4 NM_001146026.1_3 - 2.7e-13 49.8 6.3 9.2e-13 48.1 6.3 2.0 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.5 NM_001146026.1_3 - 1.2e-08 35.0 5.7 3.9e-08 33.3 5.7 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 NM_001146026.1_3 - 2.9e-08 33.3 5.6 7e-08 32.1 5.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001146026.1_3 - 4.8e-08 32.6 4.9 1.1e-07 31.4 4.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 NM_001146026.1_3 - 7e-08 31.9 3.4 7e-08 31.9 3.4 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.4 NM_001146026.1_3 - 1e-06 28.4 3.6 2.9e-06 26.9 3.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001146026.1_3 - 1.3e-06 28.2 3.9 3.2e-06 26.9 3.9 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_001146026.1_3 - 0.00012 21.8 2.7 0.00041 20.2 2.7 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 NM_001146026.1_3 - 0.0022 17.9 1.1 0.0022 17.9 1.1 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.3 NM_001146026.1_3 - 0.15 11.6 4.5 0.33 10.5 4.5 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.5 NM_001146026.1_3 - 0.96 9.5 5.4 2.1 8.4 5.4 1.6 1 0 0 1 1 1 0 RING-variant domain V1R PF03402.12 NM_134245.1_1 - 1.5e-33 116.4 19.1 1.8e-33 116.1 19.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_134245.1_1 - 1.2e-05 24.4 26.1 1.6e-05 24.0 26.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_134245.1_1 - 0.036 13.1 16.9 0.06 12.4 16.9 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) ISK_Channel PF02060.13 NM_001190869.1_2 - 1.3e-06 28.0 0.0 2.6e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Slow voltage-gated potassium channel DUF2371 PF10177.7 NM_029881.3_2 - 2e-61 206.1 0.0 3.3e-61 205.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2371) RasGEF_N PF00618.18 NM_175008.3_1 - 1.9e-14 53.7 0.3 5e-14 52.3 0.1 1.7 2 0 0 2 2 2 1 RasGEF N-terminal motif LRR_6 PF13516.4 NM_153521.2_3 - 0.00099 18.8 12.9 0.28 11.2 0.0 5.0 6 0 0 6 6 6 3 Leucine Rich repeat CH PF00307.29 NM_022321.4_1 - 2.5e-28 98.3 2.3 1.1e-14 54.4 0.0 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_022321.4_1 - 0.00071 19.2 0.1 1.1 9.1 0.0 2.5 2 0 0 2 2 2 2 CAMSAP CH domain REV1_C PF16727.3 NM_022321.4_1 - 0.14 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain zf-C2H2 PF00096.24 NM_175433.5_3 - 3.4e-43 143.6 105.6 0.00038 20.6 2.8 11.8 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_175433.5_3 - 1e-41 139.4 88.6 5.9e-06 26.4 1.3 12.8 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_175433.5_3 - 8.7e-34 113.1 97.5 0.0035 17.9 1.9 11.9 11 0 0 11 11 11 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_175433.5_3 - 1e-07 32.0 62.3 0.15 12.2 0.1 11.5 10 1 1 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_175433.5_3 - 5.6e-06 26.0 70.9 8.5e-05 22.3 1.1 11.4 11 0 0 11 11 11 5 C2H2-type zinc finger HypA PF01155.17 NM_175433.5_3 - 0.0014 18.5 0.6 0.0014 18.5 0.6 5.2 1 1 2 3 3 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-H2C2_5 PF13909.4 NM_175433.5_3 - 0.002 17.7 0.9 0.002 17.7 0.9 10.1 9 0 0 9 9 9 3 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.3 NM_175433.5_3 - 0.012 15.2 0.1 0.012 15.2 0.1 9.6 10 0 0 10 10 10 0 zinc-finger C2H2-type BolA PF01722.16 NM_175433.5_3 - 0.06 13.5 11.3 2.5 8.3 0.5 4.5 2 1 1 4 4 4 0 BolA-like protein zf-met PF12874.5 NM_175433.5_3 - 0.21 11.9 79.0 0.19 12.0 0.9 10.8 11 0 0 11 11 11 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 NM_175433.5_3 - 0.89 9.6 40.3 0.86 9.6 0.5 7.9 7 1 0 7 7 7 0 Zinc ribbon domain Scramblase PF03803.13 NM_175433.5_3 - 2.9 7.0 5.4 0.95 8.6 2.2 1.8 2 1 0 2 2 2 0 Scramblase Pkinase PF00069.23 NM_133220.2_2 - 2.7e-65 220.2 0.0 3.6e-65 219.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_133220.2_2 - 6.5e-32 110.7 0.0 9.3e-32 110.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PX PF00787.22 NM_133220.2_2 - 2.6e-22 78.8 0.2 5e-22 77.9 0.2 1.5 1 0 0 1 1 1 1 PX domain Pkinase_C PF00433.22 NM_133220.2_2 - 2.4e-05 24.8 2.5 0.00014 22.4 0.2 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_133220.2_2 - 0.00079 18.7 0.0 0.0019 17.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like S36_mt PF10937.6 NM_133220.2_2 - 0.059 14.8 0.1 0.14 13.6 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein S36, mitochondrial FTA2 PF13095.4 NM_133220.2_2 - 0.11 12.0 0.0 3 7.3 0.1 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 NM_133220.2_2 - 0.14 11.4 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family OCRL_clath_bd PF16726.3 NM_177215.3_3 - 9.9e-44 147.6 0.4 2e-43 146.7 0.4 1.5 1 0 0 1 1 1 1 Inositol polyphosphate 5-phosphatase clathrin binding domain RhoGAP PF00620.25 NM_177215.3_3 - 6.8e-26 90.8 0.2 1.3e-25 89.9 0.2 1.5 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.21 NM_177215.3_3 - 9e-09 35.5 0.0 1.7e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DuoxA PF10204.7 NM_001305262.1_1 - 4.5e-111 370.2 7.9 5.2e-111 370.0 7.9 1.0 1 0 0 1 1 1 1 Dual oxidase maturation factor Ion_trans PF00520.29 NM_008434.2_1 - 2.2e-25 89.1 13.0 3.1e-25 88.7 13.0 1.1 1 0 0 1 1 1 1 Ion transport protein KCNQ_channel PF03520.12 NM_008434.2_1 - 1.6e-24 86.7 1.7 3.3e-24 85.6 1.7 1.5 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel Ion_trans_2 PF07885.14 NM_008434.2_1 - 4.3e-11 42.5 6.8 4.3e-11 42.5 6.8 2.4 2 0 0 2 2 2 1 Ion channel DUF4613 PF15390.4 NM_008434.2_1 - 0.01 14.1 0.2 0.015 13.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) 2TM PF13239.4 NM_008434.2_1 - 3.7 7.8 6.3 1.5 9.0 2.8 2.1 2 0 0 2 2 2 0 2TM domain THF_DHG_CYH_C PF02882.17 NM_008638.2_1 - 1.1e-61 206.7 3.3 1.8e-61 206.0 3.3 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.21 NM_008638.2_1 - 2.1e-41 140.7 0.5 3.2e-41 140.1 0.5 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AlaDh_PNT_C PF01262.19 NM_008638.2_1 - 0.048 12.8 0.2 0.077 12.1 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Neil1-DNA_bind PF09292.8 NM_028347.2_1 - 2e-24 85.1 0.2 3.5e-24 84.3 0.2 1.4 1 0 0 1 1 1 1 Endonuclease VIII-like 1, DNA bind Fapy_DNA_glyco PF01149.22 NM_028347.2_1 - 7e-18 65.2 0.0 1.7e-17 64.0 0.0 1.7 2 0 0 2 2 2 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.12 NM_028347.2_1 - 4.4e-09 36.1 0.0 9.1e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Cullin PF00888.20 NM_029402.3_1 - 1.1e-172 575.7 20.9 1.4e-172 575.4 20.9 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 NM_029402.3_1 - 2.3e-26 91.5 4.7 2.3e-26 91.5 4.7 2.8 3 0 0 3 3 3 1 Cullin protein neddylation domain Rio2_N PF09202.9 NM_029402.3_1 - 0.009 16.1 1.1 0.021 14.9 0.2 2.0 2 0 0 2 2 2 1 Rio2, N-terminal Atrophin-1 PF03154.13 NM_007881.4_2 - 5.3e-235 782.9 160.9 2.6e-208 694.6 123.3 3.6 1 1 2 3 3 3 2 Atrophin-1 family MIP-T3 PF10243.7 NM_007881.4_2 - 0.0052 15.4 1.1 0.0052 15.4 1.1 3.1 3 1 0 3 3 3 1 Microtubule-binding protein MIP-T3 DUF4778 PF16008.3 NM_007881.4_2 - 5.7 6.8 8.7 24 4.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4778) HMG_box PF00505.17 NM_011438.2_1 - 3.6e-24 84.8 1.6 3.6e-24 84.8 1.6 2.3 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_011438.2_1 - 8.4e-07 29.4 0.3 8.4e-07 29.4 0.3 1.9 2 0 0 2 2 2 1 HMG-box domain OAR PF03826.15 NM_011438.2_1 - 0.2 11.4 0.6 0.42 10.4 0.6 1.6 1 0 0 1 1 1 0 OAR domain RAG1 PF12940.5 NM_009019.2_3 - 0 1255.1 0.2 0 1254.6 0.2 1.1 1 0 0 1 1 1 1 Recombination-activation protein 1 (RAG1), recombinase RAG1_imp_bd PF12560.6 NM_009019.2_3 - 2.1e-116 388.3 15.8 3.8e-116 387.5 15.8 1.4 1 0 0 1 1 1 1 RAG1 importin binding zf-RAG1 PF10426.7 NM_009019.2_3 - 2.5e-17 62.5 4.3 2.5e-17 62.5 4.3 3.3 3 0 0 3 3 3 2 Recombination-activating protein 1 zinc-finger domain zf-C3HC4 PF00097.23 NM_009019.2_3 - 1e-05 25.1 13.9 1e-05 25.1 13.9 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_009019.2_3 - 1.7e-05 24.5 13.1 1.7e-05 24.5 13.1 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 NM_009019.2_3 - 0.00029 20.5 7.9 0.0013 18.5 7.9 2.1 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.4 NM_009019.2_3 - 0.29 11.1 15.6 0.047 13.6 10.4 2.5 2 0 0 2 2 2 0 RING-type zinc-finger ELM2 PF01448.22 NM_027422.3_2 - 1.1e-07 32.4 0.0 3.3e-07 30.9 0.0 1.9 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-binding PF00249.29 NM_027422.3_2 - 3.9e-05 23.6 0.6 0.0001 22.3 0.6 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Laminin_N PF00055.15 NM_008484.2_1 - 2.5e-50 171.2 0.0 2.5e-50 171.2 0.0 2.4 2 1 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.22 NM_008484.2_1 - 5.9e-45 151.1 127.3 2e-11 43.7 11.0 7.2 7 0 0 7 7 7 6 Laminin EGF domain Laminin_II PF06009.10 NM_008484.2_1 - 8.7e-05 22.4 17.3 0.023 14.6 0.3 4.9 3 1 2 5 5 5 2 Laminin Domain II F5_F8_type_C PF00754.23 NM_008484.2_1 - 0.0037 17.2 0.0 0.0069 16.4 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Alanine_zipper PF11839.6 NM_008484.2_1 - 0.17 12.0 21.8 0.11 12.7 3.7 3.7 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein BNR_6 PF15899.3 NM_008484.2_1 - 0.19 11.7 0.5 0.55 10.3 0.5 1.7 1 0 0 1 1 1 0 BNR-Asp box repeat NPV_P10 PF05531.10 NM_008484.2_1 - 4.1 7.8 7.8 6.4 7.2 0.1 4.5 4 2 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DASH_Duo1 PF08651.8 NM_008484.2_1 - 8 6.2 6.5 3.8 7.2 0.7 3.3 4 0 0 4 4 4 0 DASH complex subunit Duo1 Tropomyosin_1 PF12718.5 NM_008484.2_1 - 8.7 6.3 28.4 0.78 9.7 0.2 4.8 4 1 0 5 5 5 0 Tropomyosin like Reprolysin PF01421.17 NM_172126.2_3 - 7e-69 231.6 0.0 1.9e-68 230.2 0.0 1.8 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_172126.2_3 - 2.1e-29 102.1 2.2 2.1e-29 102.1 2.2 3.6 3 2 0 3 3 1 1 ADAM cysteine-rich Disintegrin PF00200.21 NM_172126.2_3 - 1.5e-17 64.1 29.5 1.5e-17 64.1 29.5 4.6 5 1 0 5 5 3 1 Disintegrin Pep_M12B_propep PF01562.17 NM_172126.2_3 - 8.1e-17 61.6 0.1 1.6e-16 60.7 0.1 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_172126.2_3 - 3.6e-13 50.0 0.2 3.6e-13 50.0 0.2 1.8 2 0 0 2 2 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 NM_172126.2_3 - 1.6e-09 38.2 0.0 2.8e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_172126.2_3 - 9.1e-07 28.6 0.0 1.5e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_172126.2_3 - 0.046 13.5 0.4 0.088 12.6 0.4 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 NM_172126.2_3 - 0.12 12.1 0.2 0.19 11.4 0.2 1.3 1 0 0 1 1 1 0 Matrixin DUF3377 PF11857.6 NM_172126.2_3 - 0.4 10.5 1.8 1 9.2 1.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Col_cuticle_N PF01484.15 NM_172126.2_3 - 4.7 7.3 5.3 18 5.4 0.9 2.5 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain Latrophilin PF02354.14 NM_181039.2_2 - 2.4e-144 480.9 3.9 6.8e-144 479.4 3.9 1.7 1 1 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region OLF PF02191.14 NM_181039.2_2 - 2.5e-84 282.6 2.8 3.5e-84 282.1 2.8 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain 7tm_2 PF00002.22 NM_181039.2_2 - 4.4e-66 222.5 18.9 6.5e-66 222.0 18.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.3 NM_181039.2_2 - 8.5e-54 182.0 0.7 1.2e-53 181.5 0.7 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.16 NM_181039.2_2 - 1e-22 80.2 0.8 2.5e-22 79.0 0.8 1.7 1 0 0 1 1 1 1 Galactose binding lectin domain GPS PF01825.19 NM_181039.2_2 - 9.6e-14 51.6 5.8 2.4e-13 50.4 5.8 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 NM_181039.2_2 - 2.2e-08 34.1 1.2 6.2e-08 32.7 0.3 2.3 2 0 0 2 2 2 1 Hormone receptor domain UQ_con PF00179.24 NM_001271016.1_1 - 2.2e-10 40.2 0.0 3.5e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UQ_con PF00179.24 NM_001271016.1_3 - 2.2e-05 24.0 0.1 3.3e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RRM_1 PF00076.20 NM_001122604.1_1 - 3.1e-36 122.9 0.2 1.8e-17 62.8 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001122604.1_1 - 3.4e-14 52.6 0.2 2.2e-07 30.7 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 NM_001122604.1_1 - 8.6e-06 25.5 0.1 0.029 14.2 0.1 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.4 NM_001122604.1_1 - 0.0016 18.6 0.1 1.3 9.1 0.0 2.8 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter CSD PF00313.20 NM_001122604.1_1 - 0.11 12.2 1.4 2.6 7.9 0.1 2.4 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain Band_7 PF01145.23 NM_023231.2_3 - 5.2e-30 104.6 2.4 1.1e-29 103.6 2.4 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.3 NM_023231.2_3 - 5.6e-25 87.1 0.5 1.3e-24 85.9 0.5 1.7 1 0 0 1 1 1 1 C-terminal region of band_7 DUF4769 PF15992.3 NM_023231.2_3 - 0.038 13.6 0.2 0.057 13.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) Band_7_1 PF13421.4 NM_023231.2_3 - 0.12 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family FlgN PF05130.10 NM_023231.2_3 - 0.16 12.3 5.1 0.31 11.4 5.1 1.4 1 0 0 1 1 1 0 FlgN protein Peptidase_M19 PF01244.19 NM_027960.2_3 - 8.5e-108 360.2 0.0 1e-107 359.8 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) zf-C4 PF00105.16 NM_011584.4_2 - 2.7e-30 104.5 15.7 2.7e-30 104.5 15.7 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_011584.4_2 - 3e-24 85.6 0.3 5.4e-24 84.8 0.3 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor LpxD PF04613.12 NM_011584.4_2 - 0.11 12.1 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD WD40 PF00400.30 NM_011931.3_2 - 1.7e-19 69.6 5.0 0.1 13.4 0.0 7.3 7 0 0 7 7 6 5 WD domain, G-beta repeat zf-C3HC4_2 PF13923.4 NM_011931.3_2 - 2.4e-15 56.0 10.8 5.9e-15 54.7 10.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_011931.3_2 - 1.9e-09 37.1 12.1 5.1e-09 35.7 12.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_011931.3_2 - 3.9e-08 32.9 7.5 9.4e-08 31.7 7.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_011931.3_2 - 7.8e-08 32.1 7.2 2.1e-07 30.7 7.2 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_011931.3_2 - 7.8e-08 32.3 9.9 7.8e-08 32.3 9.9 2.5 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 NM_011931.3_2 - 2.5e-07 30.4 10.7 2.5e-07 30.4 10.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 NM_011931.3_2 - 6.6e-06 26.1 10.9 1.7e-05 24.8 10.9 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.5 NM_011931.3_2 - 0.00024 21.2 6.2 0.00096 19.3 6.2 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain ANAPC4_WD40 PF12894.5 NM_011931.3_2 - 0.00087 19.4 0.4 5.3 7.3 0.1 3.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_011931.3_2 - 0.0045 16.2 0.0 0.012 14.8 0.0 1.6 1 1 1 2 2 2 1 WD40-like domain Prok-RING_4 PF14447.4 NM_011931.3_2 - 0.018 14.7 8.6 0.076 12.8 8.3 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 NM_011931.3_2 - 0.03 13.9 9.8 0.095 12.3 9.8 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.3 NM_011931.3_2 - 0.1 12.6 4.2 0.25 11.4 4.2 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.3 NM_011931.3_2 - 0.36 10.4 6.8 1.6 8.4 6.8 2.2 1 0 0 1 1 1 0 RING-like zinc finger DZR PF12773.5 NM_011931.3_2 - 0.53 10.2 5.6 1.4 8.9 5.6 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-Nse PF11789.6 NM_011931.3_2 - 4.5 7.0 9.2 1.4 8.6 6.0 1.8 2 0 0 2 2 1 0 Zinc-finger of the MIZ type in Nse subunit DUF1265 PF06887.12 NM_011931.3_3 - 0.15 11.9 1.1 0.44 10.4 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1265) Noc2 PF03715.11 NM_021303.2_3 - 4.5e-125 416.8 3.9 6.2e-125 416.3 3.9 1.2 1 0 0 1 1 1 1 Noc2p family Imm49 PF15575.4 NM_021303.2_3 - 0.017 14.8 0.3 0.68 9.5 0.1 2.8 2 0 0 2 2 2 0 Immunity protein 49 RRM_1 PF00076.20 NM_001177883.1_1 - 5.1e-65 215.1 0.2 1.4e-20 72.7 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001177883.1_1 - 1.3e-11 44.1 0.0 0.00065 19.2 0.0 3.3 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001177883.1_1 - 0.034 14.1 0.0 2.2 8.3 0.0 3.0 3 0 0 3 3 3 0 RNA recognition motif LRR_8 PF13855.4 NM_008148.4_3 - 4.5e-78 256.8 91.6 1.2e-12 47.3 1.4 7.0 1 1 8 9 9 9 9 Leucine rich repeat LRR_4 PF12799.5 NM_008148.4_3 - 2.7e-21 75.1 49.3 0.0023 18.1 7.7 8.7 3 3 6 10 10 10 9 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_008148.4_3 - 1.9e-19 69.8 0.0 4e-05 23.5 0.0 3.4 1 1 1 3 3 3 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_008148.4_3 - 2.4e-09 36.8 17.7 0.0023 17.3 3.6 5.0 2 2 3 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.31 NM_008148.4_3 - 0.00036 20.5 37.7 5.1 7.8 0.2 11.0 10 1 0 10 10 10 2 Leucine Rich Repeat LRRCT PF01463.22 NM_008148.4_3 - 0.033 14.6 1.2 0.033 14.6 1.2 3.3 3 0 0 3 3 3 0 Leucine rich repeat C-terminal domain PTR2 PF00854.19 NM_133895.1_3 - 2.1e-124 415.2 2.8 2.7e-124 414.9 2.8 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.14 NM_133895.1_3 - 1.4e-11 43.9 24.8 5.1e-11 42.0 24.8 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.5 NM_133895.1_3 - 0.059 12.1 10.2 0.065 11.9 2.6 3.4 3 1 1 4 4 4 0 MFS_1 like family CHCH PF06747.11 NM_001110242.1_1 - 0.0037 17.2 0.1 0.0079 16.2 0.1 1.6 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.3 NM_001110242.1_1 - 0.037 13.9 0.3 0.12 12.3 0.0 2.0 2 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Acyltransferase PF01553.19 NM_008149.3_2 - 3.6e-21 75.1 0.0 7.9e-21 74.0 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase TNFR_c6 PF00020.16 NM_001308111.1_1 - 0.0049 17.1 1.8 0.015 15.5 1.8 1.9 1 0 0 1 1 1 1 TNFR/NGFR cysteine-rich region TNFR_c6 PF00020.16 NM_001308111.1_2 - 0.0011 19.2 33.1 0.013 15.8 1.5 5.7 6 0 0 6 6 6 2 TNFR/NGFR cysteine-rich region GST_N_3 PF13417.4 NM_010267.3_1 - 8e-16 58.1 0.0 1.5e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 NM_010267.3_1 - 4.5e-12 46.0 0.0 7.9e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 NM_010267.3_1 - 7.5e-10 38.5 0.0 1.4e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 NM_010267.3_1 - 4.6e-09 36.4 0.0 8.3e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 NM_010267.3_1 - 5.9e-07 29.5 0.0 1.1e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_010267.3_1 - 3.2e-06 27.1 0.1 7.1e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.7 NM_010267.3_1 - 0.085 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Gal-3-0_sulfotr PF06990.9 NM_001039219.2_3 - 3.8e-146 486.9 8.6 5.1e-146 486.5 8.6 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.12 NM_001039219.2_3 - 0.0011 18.8 0.1 0.0027 17.5 0.1 1.5 1 0 0 1 1 1 1 Sulfotransferase family MTS PF05175.12 NM_133984.2_2 - 1.2e-11 44.3 0.0 4.6e-11 42.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.4 NM_133984.2_2 - 3.2e-10 39.9 0.0 4.8e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_133984.2_2 - 2.1e-09 37.9 0.0 4e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.11 NM_133984.2_2 - 3.4e-07 29.8 0.0 5.1e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.13 NM_133984.2_2 - 2.4e-06 27.2 0.0 3.7e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.10 NM_133984.2_2 - 4.3e-05 24.0 0.0 7.2e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_133984.2_2 - 0.00015 22.2 0.0 0.00029 21.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.15 NM_133984.2_2 - 0.00026 20.4 0.0 0.00051 19.4 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase UPF0020 PF01170.16 NM_133984.2_2 - 0.00029 20.5 0.0 0.00062 19.4 0.0 1.4 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_24 PF13578.4 NM_133984.2_2 - 0.0025 18.7 0.0 0.0047 17.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.7 NM_133984.2_2 - 0.0039 16.8 0.0 0.0061 16.2 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltr_RsmB-F PF01189.15 NM_133984.2_2 - 0.0039 16.7 0.0 0.0061 16.1 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_32 PF13679.4 NM_133984.2_2 - 0.0039 17.0 0.0 0.0072 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.5 NM_133984.2_2 - 0.0043 16.9 0.0 0.0076 16.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.8 NM_133984.2_2 - 0.0057 16.3 0.0 0.0099 15.5 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_23 PF13489.4 NM_133984.2_2 - 0.017 14.9 0.0 0.045 13.5 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain PCMT PF01135.17 NM_133984.2_2 - 0.038 13.6 0.0 0.055 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.18 NM_133984.2_2 - 0.047 12.6 0.0 0.076 11.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase GCD14 PF08704.8 NM_133984.2_2 - 0.048 13.2 0.0 0.074 12.6 0.0 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit zf-MIZ PF02891.18 NM_001005867.1_1 - 4.5e-23 80.6 4.5 4.5e-23 80.6 4.5 2.5 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 NM_001005867.1_1 - 1.4e-05 24.7 1.1 1.4e-05 24.7 1.1 2.3 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit 7tm_4 PF13853.4 NM_146600.1_1 - 7.9e-46 156.9 11.4 9.3e-46 156.7 11.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146600.1_1 - 4.6e-24 84.9 13.5 1.1e-23 83.7 13.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146600.1_1 - 0.00017 20.9 11.2 0.00024 20.4 11.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CD34_antigen PF06365.10 NM_001286641.1_3 - 0.0013 18.3 0.0 0.0021 17.6 0.0 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family TLD PF07534.14 NM_028883.2_2 - 2.3e-36 125.0 0.3 3.7e-36 124.3 0.3 1.3 1 0 0 1 1 1 1 TLD LRR_8 PF13855.4 NM_183141.2_1 - 5.5e-23 80.4 11.5 5e-13 48.5 2.8 2.9 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_183141.2_1 - 3.8e-06 27.0 9.1 0.0079 16.4 0.1 3.2 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_183141.2_1 - 3.9e-06 26.7 0.0 8.5e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_183141.2_1 - 0.08 12.3 0.1 0.26 10.6 0.1 1.6 1 1 1 2 2 2 0 Leucine-rich repeat fn3 PF00041.19 NM_183141.2_1 - 0.083 13.1 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 Fibronectin type III domain Bunya_G2 PF03563.11 NM_183141.2_1 - 0.12 11.4 0.4 0.2 10.7 0.4 1.2 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 7tm_4 PF13853.4 NM_001011776.1_1 - 4.6e-45 154.4 15.5 6.1e-45 154.0 15.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011776.1_1 - 1.3e-22 80.2 17.8 2.1e-22 79.5 17.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011776.1_1 - 6.2e-07 28.9 6.1 6.2e-07 28.9 6.1 2.2 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001011776.1_1 - 0.0003 20.1 8.3 0.0003 20.1 8.3 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Vps26 PF03643.13 NM_001113355.1_3 - 2.8e-133 443.0 4.5 3.5e-133 442.6 4.5 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 EB1 PF03271.15 NM_001162942.1_2 - 2.6e-15 56.2 0.9 5.2e-15 55.3 0.9 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.29 NM_001162942.1_2 - 3.5e-11 43.1 0.2 6.1e-11 42.3 0.2 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_001162942.1_2 - 0.012 15.3 0.1 0.028 14.1 0.1 1.5 1 0 0 1 1 1 0 CAMSAP CH domain ING PF12998.5 NM_001162942.1_2 - 0.051 14.0 1.0 0.098 13.1 1.0 1.4 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding SH3BP5 PF05276.12 NM_001308167.1_1 - 2.5e-90 302.2 19.9 3.3e-90 301.8 19.9 1.1 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) Tropomyosin_1 PF12718.5 NM_001308167.1_1 - 0.0089 16.0 4.8 0.0089 16.0 4.8 2.4 2 1 0 2 2 2 1 Tropomyosin like FlaC_arch PF05377.9 NM_001308167.1_1 - 0.78 10.0 2.9 2 8.7 0.2 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) PDZ PF00595.22 NM_001324521.1_1 - 2.3e-14 53.3 0.8 3.6e-14 52.7 0.8 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001324521.1_1 - 0.00044 20.4 0.1 0.0008 19.5 0.1 1.3 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 NM_001324521.1_1 - 0.14 12.0 0.1 2.1 8.3 0.1 2.2 2 0 0 2 2 2 0 Tricorn protease PDZ domain PH PF00169.27 NM_001324521.1_2 - 0.00014 22.2 0.0 0.26 11.7 0.0 2.8 2 1 0 2 2 2 2 PH domain BTB_2 PF02214.20 NM_177715.4_3 - 1.7e-14 53.8 0.0 2.8e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain TPH PF13868.4 NM_029992.2_3 - 2.6e-31 108.3 142.3 2.6e-31 108.3 142.3 2.6 2 1 0 2 2 2 1 Trichohyalin-plectin-homology domain Ig_Tie2_1 PF10430.7 NM_029992.2_3 - 1.7 9.0 8.7 0.11 12.8 1.2 2.9 3 0 0 3 3 3 0 Tie-2 Ig-like domain 1 CH PF00307.29 NM_001281818.1_1 - 1.1e-20 73.8 0.0 2.5e-20 72.6 0.0 1.7 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_001281818.1_1 - 3.1e-06 26.8 0.0 7.3e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain HAP1_N PF04849.11 NM_001281818.1_1 - 0.0011 18.1 4.1 0.0011 18.1 4.1 4.6 2 1 2 4 4 4 1 HAP1 N-terminal conserved region Fez1 PF06818.13 NM_001281818.1_1 - 0.0039 17.5 2.8 0.0039 17.5 2.8 4.5 2 1 2 4 4 4 1 Fez1 DUF4200 PF13863.4 NM_001281818.1_1 - 0.0053 17.0 13.0 0.0053 17.0 13.0 6.9 4 2 3 7 7 7 2 Domain of unknown function (DUF4200) Cytochrom_C_2 PF01322.18 NM_001281818.1_1 - 1.8 9.3 13.1 0.81 10.5 2.4 3.3 3 0 0 3 3 3 0 Cytochrome C' 7tm_4 PF13853.4 NM_146688.1_1 - 6.7e-55 186.7 25.4 8e-55 186.4 25.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146688.1_1 - 3.5e-20 72.2 30.2 3.5e-20 72.2 30.2 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) VEGF_C PF14554.4 NM_001110267.1_2 - 5.4e-28 96.7 21.3 5.4e-28 96.7 21.3 2.2 2 0 0 2 2 2 1 VEGF heparin-binding domain 7tm_4 PF13853.4 NM_146360.2_1 - 4.2e-95 318.5 24.5 5e-95 318.3 24.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146360.2_1 - 6.4e-17 61.5 27.6 2.2e-16 59.8 27.6 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146360.2_1 - 2.6e-07 30.1 13.4 2.6e-07 30.1 13.4 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx eIF-5a PF01287.18 NM_001166594.1_1 - 4.4e-25 87.4 0.2 6.4e-25 86.9 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.10 NM_001166594.1_1 - 0.02 14.8 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain TAS2R PF05296.11 NM_207021.1_1 - 7.7e-84 281.2 44.9 1e-83 280.8 44.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Pkinase PF00069.23 NM_009445.2_3 - 2.5e-65 220.3 1.2 3.8e-65 219.8 1.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_009445.2_3 - 1.7e-31 109.4 0.3 2.5e-31 108.8 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_009445.2_3 - 5.1e-05 22.6 0.1 0.0018 17.5 0.0 2.3 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.20 NM_009445.2_3 - 0.0021 17.5 2.1 0.009 15.5 0.3 2.2 1 1 1 2 2 2 1 RIO1 family FTA2 PF13095.4 NM_009445.2_3 - 0.0026 17.3 0.4 0.055 12.9 0.0 2.3 1 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.21 NM_009445.2_3 - 0.0036 17.1 0.0 2.4 7.9 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 NM_009445.2_3 - 0.0045 16.2 0.1 0.0081 15.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Mad3_BUB1_I PF08311.10 NM_009445.2_3 - 0.0084 15.9 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_I_2 PF17014.3 NM_009445.2_3 - 0.03 14.3 1.1 0.049 13.6 0.1 1.9 2 0 0 2 2 2 0 Putative Mad3/BUB1 like region 1 protein Tubulin PF00091.23 NM_009445.2_3 - 0.038 14.0 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain TPR_14 PF13428.4 NM_009445.2_3 - 0.11 13.2 0.1 33 5.5 0.0 2.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.4 NM_009445.2_3 - 0.16 12.2 0.2 31 4.8 0.0 2.7 2 1 0 3 3 2 0 Tetratricopeptide repeat BORG_CEP PF14957.4 NM_021454.3_1 - 6.7e-09 36.8 0.0 1.1e-08 36.0 0.0 1.4 1 0 0 1 1 1 1 Cdc42 effector PBD PF00786.26 NM_021454.3_1 - 4.3e-06 26.9 0.1 7.6e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain C2-set_2 PF08205.10 NM_021495.4_2 - 3.3e-18 65.4 0.1 4.7e-17 61.7 0.0 2.5 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 NM_021495.4_2 - 1.7e-16 60.5 1.3 3e-06 27.6 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_021495.4_2 - 2.4e-13 50.1 0.3 4.1e-11 42.9 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 NM_021495.4_2 - 2.8e-12 46.5 0.6 0.00029 20.8 0.2 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_021495.4_2 - 4.6e-11 42.5 3.0 3e-07 30.3 0.1 3.7 4 1 0 4 4 4 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_021495.4_2 - 4e-09 36.6 0.9 0.0056 16.9 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.3 NM_021495.4_2 - 0.016 15.5 0.5 5.8 7.3 0.0 3.4 3 1 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.13 NM_021495.4_2 - 0.045 14.1 0.2 0.2 12.0 0.0 2.3 3 0 0 3 3 3 0 Immunoglobulin C1-set domain PDGLE PF13190.4 NM_021495.4_2 - 0.086 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 PDGLE domain DUF321 PF03778.11 NM_021495.4_3 - 0.53 9.9 3.4 0.14 11.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF321) LCE PF14672.4 NM_026822.1_1 - 5.1e-14 52.5 127.6 2.2e-08 34.5 52.2 4.7 1 1 2 3 3 3 2 Late cornified envelope Caveolin PF01146.15 NM_007617.3_2 - 2e-57 192.7 1.3 2.7e-57 192.3 1.3 1.1 1 0 0 1 1 1 1 Caveolin adh_short PF00106.23 NM_019573.3_1 - 6.9e-26 90.8 0.0 5e-22 78.2 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase WW PF00397.24 NM_019573.3_1 - 8.4e-18 63.9 11.9 2.2e-09 37.0 7.3 2.6 2 0 0 2 2 2 2 WW domain adh_short_C2 PF13561.4 NM_019573.3_1 - 7.5e-16 58.3 0.1 6.1e-14 52.0 0.1 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_019573.3_1 - 3.8e-07 30.1 0.1 5.7e-07 29.5 0.1 1.2 1 0 0 1 1 1 1 KR domain PerB PF06590.9 NM_019573.3_1 - 0.13 12.7 0.0 0.66 10.4 0.0 2.1 3 0 0 3 3 3 0 PerB protein zf-H2C2_2 PF13465.4 NM_001309388.1_1 - 1.7e-70 230.4 125.5 1.4e-08 34.7 2.7 14.5 15 0 0 15 15 15 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001309388.1_1 - 2.6e-47 156.6 133.5 1e-05 25.6 1.3 14.9 15 0 0 15 15 14 10 Zinc finger, C2H2 type KRAB PF01352.25 NM_001309388.1_1 - 8.2e-23 79.7 0.1 1.5e-22 78.8 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_001309388.1_1 - 1.6e-21 75.0 125.4 0.0053 17.3 0.5 14.7 15 0 0 15 15 13 10 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001309388.1_1 - 9.1e-14 50.8 64.8 0.018 14.7 0.2 11.8 12 0 0 12 12 12 8 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 NM_001309388.1_1 - 1.3e-13 50.4 107.2 0.0069 16.2 3.6 14.2 14 0 0 14 14 13 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001309388.1_1 - 4e-08 33.2 63.2 0.076 13.2 0.6 11.5 12 0 0 12 12 11 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001309388.1_1 - 4.6e-07 29.7 78.1 0.038 14.0 3.7 10.9 7 4 6 14 14 14 9 Zinc ribbon domain zf-trcl PF13451.4 NM_001309388.1_1 - 0.0041 16.9 65.0 2.9 7.7 0.1 13.0 12 2 1 13 13 13 4 Probable zinc-ribbon domain zf-met PF12874.5 NM_001309388.1_1 - 0.0089 16.3 96.6 0.0096 16.2 1.1 12.4 12 0 0 12 12 12 5 Zinc-finger of C2H2 type ADK_lid PF05191.12 NM_001309388.1_1 - 0.013 15.3 39.7 0.54 10.2 2.9 6.8 5 1 0 6 6 6 0 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 NM_001309388.1_1 - 0.28 11.8 66.4 0.6 10.8 2.2 8.0 3 1 4 7 7 7 0 zinc-ribbon family XPA_N PF01286.16 NM_001309388.1_1 - 0.35 10.8 67.1 2.4 8.1 0.1 12.6 14 0 0 14 14 13 0 XPA protein N-terminal HypA PF01155.17 NM_001309388.1_1 - 2.3 8.1 51.7 0.082 12.8 0.9 7.0 3 1 4 7 7 7 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Apolipoprotein PF01442.16 NM_001305819.1_1 - 1.4e-56 191.4 15.6 1.4e-56 191.4 15.6 1.6 2 0 0 2 2 2 1 Apolipoprotein A1/A4/E domain DUF883 PF05957.11 NM_001305819.1_1 - 9.5e-06 26.0 25.0 0.11 12.9 3.4 4.6 1 1 4 5 5 5 5 Bacterial protein of unknown function (DUF883) Baculo_PEP_C PF04513.10 NM_001305819.1_1 - 0.00013 21.9 1.3 4.8 7.1 0.4 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ApoLp-III PF07464.9 NM_001305819.1_1 - 0.0002 21.3 8.7 0.013 15.4 1.3 2.9 2 1 0 2 2 2 2 Apolipophorin-III precursor (apoLp-III) GldM_N PF12081.6 NM_001305819.1_1 - 0.0026 17.7 1.9 0.011 15.7 0.7 2.2 2 0 0 2 2 2 1 GldM N-terminal domain DUF948 PF06103.9 NM_001305819.1_1 - 0.026 14.6 2.8 9.5 6.4 0.4 3.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1690 PF07956.9 NM_001305819.1_1 - 0.046 14.0 12.4 0.18 12.1 4.6 3.0 2 1 1 3 3 3 0 Protein of Unknown function (DUF1690) Lectin_N PF03954.12 NM_001305819.1_1 - 0.061 12.9 4.2 0.18 11.4 0.9 2.6 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain DUF1043 PF06295.10 NM_001305819.1_1 - 0.076 12.9 0.3 0.076 12.9 0.3 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1043) BshC PF10079.7 NM_001305819.1_1 - 0.084 11.5 10.8 0.37 9.3 3.0 2.6 2 1 0 2 2 2 0 Bacillithiol biosynthesis BshC DUF1664 PF07889.10 NM_001305819.1_1 - 0.089 12.7 7.8 1.5 8.7 0.6 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) CAP_N PF01213.17 NM_001305819.1_1 - 0.091 12.1 2.4 1.2 8.4 0.0 2.1 1 1 1 2 2 2 0 Adenylate cyclase associated (CAP) N terminal YtxH PF12732.5 NM_001305819.1_1 - 0.11 12.9 13.8 0.49 10.8 0.3 4.4 1 1 2 3 3 3 0 YtxH-like protein PrkA PF06798.10 NM_001305819.1_1 - 0.14 11.6 6.9 0.022 14.2 2.2 1.8 2 0 0 2 2 2 0 PrkA serine protein kinase C-terminal domain Prominin PF05478.9 NM_001305819.1_1 - 0.19 9.5 3.7 0.59 7.9 3.6 1.8 1 1 0 1 1 1 0 Prominin DUF4795 PF16043.3 NM_001305819.1_1 - 0.19 11.2 14.0 2.9 7.3 0.3 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) Phasin PF05597.9 NM_001305819.1_1 - 0.31 10.9 15.1 0.66 9.9 1.1 3.2 1 1 2 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DIT1_PvcA PF05141.10 NM_001305819.1_1 - 0.35 10.1 5.8 0.11 11.8 2.1 1.8 2 0 0 2 2 2 0 Pyoverdine/dityrosine biosynthesis protein YojJ PF10372.7 NM_001305819.1_1 - 0.36 10.8 6.0 6.9 6.7 0.4 3.6 2 1 1 3 3 3 0 Bacterial membrane-spanning protein N-terminus Fib_alpha PF08702.8 NM_001305819.1_1 - 0.39 10.8 9.6 4.6 7.3 2.0 2.9 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Phage_Mu_Gam PF07352.10 NM_001305819.1_1 - 0.42 10.4 8.4 5.8 6.7 0.5 3.2 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein RmuC PF02646.14 NM_001305819.1_1 - 0.79 8.7 10.0 1.9 7.4 0.2 3.1 2 1 1 3 3 3 0 RmuC family Snapin_Pallidin PF14712.4 NM_001305819.1_1 - 0.82 10.0 14.8 1.5 9.2 2.2 3.4 2 1 1 3 3 3 0 Snapin/Pallidin Stathmin PF00836.17 NM_001305819.1_1 - 1 9.2 14.1 0.57 10.0 1.4 2.7 2 1 1 3 3 3 0 Stathmin family AKNA PF12443.6 NM_001305819.1_1 - 1.2 9.7 8.8 2 9.0 0.7 3.0 2 1 1 3 3 3 0 AT-hook-containing transcription factor Exonuc_VII_L PF02601.13 NM_001305819.1_1 - 1.3 8.4 16.1 7.3e+02 -0.6 16.1 2.2 1 1 0 1 1 1 0 Exonuclease VII, large subunit Syntaxin_2 PF14523.4 NM_001305819.1_1 - 1.3 9.3 8.0 9.7 6.5 1.3 3.1 2 1 1 3 3 3 0 Syntaxin-like protein CREPT PF16566.3 NM_001305819.1_1 - 1.5 8.8 13.6 6 6.9 6.0 3.0 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF2884 PF11101.6 NM_001305819.1_1 - 1.6 8.0 15.7 1.7 8.0 6.4 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF2884) DUF1451 PF07295.9 NM_001305819.1_1 - 1.6 8.6 12.9 0.73 9.7 0.6 3.0 2 1 1 3 3 3 0 Zinc-ribbon containing domain DUF2130 PF09903.7 NM_001305819.1_1 - 2.1 7.4 7.1 2.2 7.4 0.3 2.8 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2130) OmpH PF03938.12 NM_001305819.1_1 - 2.2 8.2 22.1 2.9 7.7 7.8 3.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) RRF PF01765.17 NM_001305819.1_1 - 2.4 8.0 9.6 4.5 7.1 0.8 2.7 2 1 0 2 2 2 0 Ribosome recycling factor TBPIP PF07106.11 NM_001305819.1_1 - 2.7 7.6 10.7 11 5.6 0.1 3.0 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Uso1_p115_C PF04871.11 NM_001305819.1_1 - 3.6 7.8 17.3 1.4 9.1 0.6 3.2 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region CorA PF01544.16 NM_001305819.1_1 - 4.2 6.5 11.6 2.6 7.2 3.1 2.3 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Fzo_mitofusin PF04799.11 NM_001305819.1_1 - 4.4 6.7 14.1 2 7.8 4.0 3.3 2 1 1 3 3 3 0 fzo-like conserved region Ku_C PF03730.12 NM_001305819.1_1 - 4.5 7.9 6.8 61 4.3 0.1 3.7 2 2 2 4 4 3 0 Ku70/Ku80 C-terminal arm Phe_tRNA-synt_N PF02912.16 NM_001305819.1_1 - 8.3 6.3 11.9 1.8 8.5 0.7 3.7 2 1 2 4 4 4 0 Aminoacyl tRNA synthetase class II, N-terminal domain BEX PF04538.10 NM_001305819.1_1 - 8.6 6.9 17.4 2.2 8.8 5.3 2.3 1 1 0 2 2 2 0 Brain expressed X-linked like family Phage_GPO PF05929.9 NM_001305819.1_1 - 9.3 5.7 12.6 4.4 6.7 0.5 2.5 1 1 2 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase V-set PF07686.15 NM_001289915.1_1 - 1.1e-05 25.5 0.5 3.9e-05 23.6 0.5 1.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 NM_001289915.1_1 - 1.5e-05 25.0 0.8 2.6e-05 24.2 0.2 1.7 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 NM_001289915.1_1 - 2.1e-05 24.4 0.0 3.5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001289915.1_1 - 0.0011 19.4 1.6 0.0015 18.9 0.5 1.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 NM_001289915.1_1 - 0.017 15.3 0.1 0.032 14.4 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin domain EPTP PF03736.15 NM_020278.2_3 - 2.3e-67 222.6 19.6 2e-12 46.7 0.1 7.6 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.4 NM_020278.2_3 - 2.6e-21 75.0 11.9 3.9e-15 55.2 4.6 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 NM_020278.2_3 - 2.6e-08 33.9 8.4 0.00044 20.4 2.6 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_020278.2_3 - 3.2e-07 30.2 1.6 7.7e-07 29.0 1.6 1.5 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_020278.2_3 - 0.019 14.3 0.1 0.035 13.5 0.1 1.4 1 0 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.31 NM_020278.2_3 - 4.8 7.9 7.9 7.4 7.3 0.5 3.9 3 0 0 3 3 3 0 Leucine Rich Repeat GDNF PF02351.14 NM_008086.2_1 - 1.2e-05 26.1 30.7 0.00047 20.9 10.2 2.7 3 0 0 3 3 3 2 GDNF/GAS1 domain Cadherin PF00028.15 NM_153508.4_1 - 2.9e-13 49.9 0.0 1.1e-06 28.8 0.0 2.4 2 0 0 2 2 2 2 Cadherin domain Laminin_G_3 PF13385.4 NM_153508.4_1 - 0.00018 21.6 0.0 0.00042 20.3 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily ETRAMP PF09716.8 NM_010404.3_1 - 0.28 11.1 5.4 0.43 10.5 5.4 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) HAP1_N PF04849.11 NM_010404.3_2 - 2e-106 355.5 17.2 3.4e-106 354.8 17.2 1.3 1 0 0 1 1 1 1 HAP1 N-terminal conserved region GIT1_C PF12205.6 NM_010404.3_2 - 6.1 6.9 8.9 5.3 7.1 3.4 2.5 1 1 1 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term SR-25 PF10500.7 NM_010404.3_3 - 1.6 8.1 21.9 0.16 11.4 13.2 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RNA_pol_Rpc4 PF05132.12 NM_025945.3_1 - 6.3e-29 101.2 0.1 6.3e-29 101.2 0.1 3.0 3 0 0 3 3 3 1 RNA polymerase III RPC4 FXMRP1_C_core PF12235.6 NM_011814.2_3 - 2.4e-33 115.5 8.5 2.4e-33 115.5 8.5 3.3 2 1 2 4 4 4 1 Fragile X-related 1 protein core C terminal FXR_C1 PF16096.3 NM_011814.2_3 - 7.3e-33 112.5 3.2 7.3e-33 112.5 3.2 3.4 2 1 1 3 3 3 1 Fragile X-related 1 protein C-terminal region 2 KH_1 PF00013.27 NM_011814.2_3 - 2.1e-18 65.8 0.8 3.1e-11 42.8 0.4 2.5 2 0 0 2 2 2 2 KH domain Agenet PF05641.10 NM_011814.2_3 - 1.3e-13 51.1 2.7 2.5e-09 37.4 0.1 3.0 3 0 0 3 3 3 2 Agenet domain KH_2 PF07650.15 NM_011814.2_3 - 0.0032 17.1 0.8 0.97 9.2 0.0 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.4 NM_011814.2_3 - 0.031 14.0 0.1 1.9 8.3 0.0 2.6 2 0 0 2 2 2 0 KH domain DUF3252 PF11623.6 NM_011814.2_3 - 0.12 12.0 0.1 0.23 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3252) DUF4347 PF14252.4 NM_001039387.1_1 - 0.00058 19.6 0.0 0.00097 18.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) IQ PF00612.25 NM_001039387.1_1 - 0.0034 16.9 4.4 0.23 11.2 0.1 3.0 3 0 0 3 3 3 2 IQ calmodulin-binding motif HMG_box PF00505.17 NM_023434.3_3 - 1.5e-17 63.6 0.7 2.5e-17 62.9 0.7 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_023434.3_3 - 1.4e-11 44.7 1.1 2.8e-11 43.7 1.1 1.5 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.11 NM_023434.3_3 - 0.079 13.4 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 YABBY protein VWA PF00092.26 NM_013592.4_2 - 1.7e-94 314.9 0.0 2.2e-49 167.9 0.0 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 NM_013592.4_2 - 3.8e-34 117.4 0.0 1.3e-15 57.8 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain FXa_inhibition PF14670.4 NM_013592.4_2 - 6.3e-30 103.0 55.9 1.1e-09 38.3 7.8 4.5 4 0 0 4 4 4 4 Coagulation Factor Xa inhibitory site cEGF PF12662.5 NM_013592.4_2 - 3.2e-18 65.2 25.8 5.4e-06 26.1 0.5 4.8 4 0 0 4 4 4 4 Complement Clr-like EGF-like EGF_CA PF07645.13 NM_013592.4_2 - 1.8e-12 47.1 44.3 2.1e-05 24.5 5.7 4.5 4 0 0 4 4 4 4 Calcium-binding EGF domain Matrilin_ccoil PF10393.7 NM_013592.4_2 - 3.6e-12 45.8 0.9 9.2e-12 44.5 0.9 1.7 1 0 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin EGF PF00008.25 NM_013592.4_2 - 2.3e-10 40.4 41.6 0.0015 18.7 4.3 4.8 4 0 0 4 4 4 4 EGF-like domain DUF1194 PF06707.9 NM_013592.4_2 - 0.0019 17.3 0.0 0.12 11.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1194) hEGF PF12661.5 NM_013592.4_2 - 0.02 15.4 2.3 0.02 15.4 2.3 5.1 4 0 0 4 4 4 0 Human growth factor-like EGF zf-C2H2 PF00096.24 NM_001289481.1_1 - 1.7e-63 207.5 121.0 3.6e-06 27.0 2.2 13.6 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001289481.1_1 - 8.8e-59 193.3 92.6 6.7e-08 32.5 0.8 14.8 14 1 0 14 14 14 11 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001289481.1_1 - 1.5e-40 134.2 112.4 0.00044 20.7 1.7 13.8 14 0 0 14 14 13 13 C2H2-type zinc finger SCAN PF02023.15 NM_001289481.1_1 - 2.5e-29 100.8 0.1 6.2e-29 99.5 0.1 1.7 1 0 0 1 1 1 1 SCAN domain zf-C2H2_jaz PF12171.6 NM_001289481.1_1 - 4.1e-11 42.8 43.4 0.33 11.2 0.0 12.2 12 0 0 12 12 12 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001289481.1_1 - 8e-10 38.5 56.2 0.015 15.3 1.1 10.0 7 1 3 10 10 10 6 Zinc ribbon domain zf-met PF12874.5 NM_001289481.1_1 - 8.7e-08 32.2 77.1 0.0019 18.4 1.2 11.9 12 0 0 12 12 12 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 NM_001289481.1_1 - 2.4e-07 30.4 92.3 0.21 11.5 2.8 13.5 13 0 0 13 13 13 8 C2H2-type zinc finger ADK_lid PF05191.12 NM_001289481.1_1 - 0.00042 20.1 30.0 1.2 9.1 0.2 8.9 5 3 3 8 8 8 2 Adenylate kinase, active site lid zf-C2H2_11 PF16622.3 NM_001289481.1_1 - 0.03 14.0 0.4 0.03 14.0 0.4 12.5 13 0 0 13 13 13 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_001289481.1_1 - 0.08 13.6 46.3 1.2 9.8 0.9 6.8 3 3 4 7 7 7 0 zinc-ribbon family zf-C2H2_9 PF16293.3 NM_001289481.1_1 - 0.89 9.3 26.5 14 5.5 0.0 8.6 8 1 1 9 9 9 0 C2H2 type zinc-finger (1 copy) GAGA PF09237.9 NM_001289481.1_1 - 2 8.2 60.4 0.32 10.7 0.8 8.8 3 1 6 10 10 10 0 GAGA factor FYDLN_acid PF09538.8 NM_001289481.1_1 - 5.6 7.6 27.8 26 5.4 1.2 9.0 2 2 8 10 10 9 0 Protein of unknown function (FYDLN_acid) zf-LYAR PF08790.9 NM_001289481.1_1 - 8.1 6.3 46.2 0.98 9.3 1.2 10.8 12 0 0 12 12 12 0 LYAR-type C2HC zinc finger zf-C2H2_2 PF12756.5 NM_001289481.1_1 - 8.4 6.7 61.0 1.9 8.7 0.1 9.7 1 1 9 10 10 10 0 C2H2 type zinc-finger (2 copies) GPHH PF16905.3 NM_001289481.1_3 - 0.15 11.7 0.2 0.38 10.5 0.2 1.6 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated Filament PF00038.19 NM_008471.3_2 - 2.3e-118 395.2 23.2 2.6e-118 395.0 23.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein DivIC PF04977.13 NM_008471.3_2 - 0.00083 18.9 14.7 0.2 11.3 0.8 4.5 4 0 0 4 4 4 2 Septum formation initiator POX PF07526.9 NM_008471.3_2 - 0.0076 16.7 0.2 0.17 12.4 0.4 2.5 2 0 0 2 2 2 1 Associated with HOX Bacillus_HBL PF05791.9 NM_008471.3_2 - 0.0089 15.6 4.0 0.0089 15.6 4.0 2.9 1 1 0 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) BRE1 PF08647.9 NM_008471.3_2 - 0.009 15.9 0.7 0.009 15.9 0.7 4.1 3 1 1 4 4 4 1 BRE1 E3 ubiquitin ligase Taxilin PF09728.7 NM_008471.3_2 - 0.03 13.5 16.4 0.068 12.3 8.7 2.8 2 1 0 2 2 2 0 Myosin-like coiled-coil protein TPR_MLP1_2 PF07926.10 NM_008471.3_2 - 0.045 13.7 22.5 0.062 13.2 0.1 3.7 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.4 NM_008471.3_2 - 0.056 12.7 17.0 0.032 13.5 9.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) Jnk-SapK_ap_N PF09744.7 NM_008471.3_2 - 0.062 13.4 0.6 0.062 13.4 0.6 3.4 3 1 1 4 4 4 0 JNK_SAPK-associated protein-1 TPD52 PF04201.13 NM_008471.3_2 - 0.071 12.6 8.9 0.37 10.3 1.3 3.5 3 1 1 4 4 3 0 Tumour protein D52 family DUF2461 PF09365.8 NM_008471.3_2 - 0.16 11.8 0.4 22 4.8 0.0 2.4 2 1 0 2 2 2 0 Conserved hypothetical protein (DUF2461) Prefoldin PF02996.15 NM_008471.3_2 - 0.19 11.5 16.8 0.18 11.6 8.7 3.7 3 1 0 3 3 2 0 Prefoldin subunit SlyX PF04102.10 NM_008471.3_2 - 0.24 11.9 20.3 3.5 8.2 3.1 4.7 3 1 1 4 4 4 0 SlyX Lectin_N PF03954.12 NM_008471.3_2 - 0.32 10.6 8.0 0.25 11.0 1.3 3.1 2 1 1 3 3 2 0 Hepatic lectin, N-terminal domain ADIP PF11559.6 NM_008471.3_2 - 0.44 10.5 24.7 1.3 8.9 1.4 3.9 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.10 NM_008471.3_2 - 0.51 10.2 17.8 2.9 7.7 2.4 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) PHA_gran_rgn PF09650.8 NM_008471.3_2 - 0.67 10.2 4.9 13 6.1 0.1 3.8 1 1 4 5 5 5 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) CC2-LZ PF16516.3 NM_008471.3_2 - 0.69 10.1 14.7 1.2 9.4 0.3 3.3 2 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator RasGAP_C PF03836.13 NM_008471.3_2 - 0.8 9.7 15.7 0.43 10.6 0.7 3.3 2 1 2 4 4 4 0 RasGAP C-terminus CHDCT2 PF08074.9 NM_008471.3_2 - 0.93 9.5 7.0 0.57 10.2 4.4 1.9 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain T2SSM PF04612.10 NM_008471.3_2 - 0.93 9.4 9.2 6.9 6.6 0.0 3.4 1 1 3 4 4 4 0 Type II secretion system (T2SS), protein M Spc7 PF08317.9 NM_008471.3_2 - 0.93 8.2 23.9 1.1 8.0 2.7 2.9 1 1 1 3 3 3 0 Spc7 kinetochore protein SseC PF04888.10 NM_008471.3_2 - 1.3 8.3 9.4 0.064 12.6 4.0 1.5 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Rab_bind PF16704.3 NM_008471.3_2 - 1.4 8.9 6.6 39 4.2 0.1 3.4 2 1 1 3 3 3 0 Rab binding domain Baculo_PEP_C PF04513.10 NM_008471.3_2 - 1.4 8.8 16.2 5.2 7.0 0.3 3.9 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prefoldin_2 PF01920.18 NM_008471.3_2 - 2.8 7.8 19.4 3.7 7.4 0.5 4.6 4 1 0 4 4 4 0 Prefoldin subunit DUF641 PF04859.10 NM_008471.3_2 - 2.9 8.1 16.5 6.5 7.0 0.4 3.6 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) IncA PF04156.12 NM_008471.3_2 - 5 6.7 27.5 15 5.2 14.2 3.5 1 1 1 3 3 3 0 IncA protein FlaC_arch PF05377.9 NM_008471.3_2 - 6.3 7.1 16.2 1.2 9.4 0.3 4.3 5 0 0 5 5 3 0 Flagella accessory protein C (FlaC) Atg14 PF10186.7 NM_008471.3_2 - 8.6 5.2 15.5 3.8 6.4 2.0 2.8 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF972 PF06156.11 NM_008471.3_2 - 9.1 6.8 19.9 3.8 8.0 0.5 4.7 2 2 3 5 5 5 0 Protein of unknown function (DUF972) ERG2_Sigma1R PF04622.10 NM_001286538.1_3 - 8.1e-40 136.3 0.1 1.2e-39 135.8 0.1 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein DUF2810 PF10928.6 NM_001286538.1_3 - 0.039 13.8 0.0 0.094 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2810) CD20 PF04103.13 NM_001166376.1_2 - 8.1e-09 35.6 1.7 1.2e-08 35.1 1.7 1.2 1 0 0 1 1 1 1 CD20-like family Spore_YhcN_YlaJ PF09580.8 NM_001081354.2_2 - 0.77 9.7 16.9 4 7.3 16.8 2.1 1 1 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) PNRC PF15365.4 NM_001081354.2_2 - 0.98 9.9 0.0 0.98 9.9 0.0 6.9 5 1 0 5 5 5 0 Proline-rich nuclear receptor coactivator MecA PF05389.10 NM_001081354.2_2 - 1.5 8.2 13.5 0.92 9.0 1.4 2.3 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) EOS1 PF12326.6 NM_001081354.2_2 - 2.8 7.7 9.7 7.2 6.4 0.1 2.4 2 0 0 2 2 2 0 N-glycosylation protein VMA21 PF09446.8 NM_001290781.1_3 - 5.2e-22 77.6 10.5 1.1e-21 76.6 10.5 1.6 1 0 0 1 1 1 1 VMA21-like domain BTB PF00651.29 NM_001039511.1_1 - 2.5e-27 95.2 0.2 4.3e-27 94.4 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 NM_001039511.1_1 - 3.6e-12 46.2 0.4 8.5e-12 45.0 0.2 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch CTP_synth_N PF06418.12 NM_001168571.1_3 - 4.7e-130 432.5 0.5 5.9e-130 432.2 0.5 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.26 NM_001168571.1_3 - 1.3e-35 122.8 0.0 2.8e-28 98.8 0.0 2.2 1 1 1 2 2 2 2 Glutamine amidotransferase class-I CbiA PF01656.21 NM_001168571.1_3 - 0.029 14.3 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Peptidase_C26 PF07722.11 NM_001168571.1_3 - 0.029 14.0 0.6 1 8.9 0.1 2.2 2 0 0 2 2 2 0 Peptidase C26 ATP1G1_PLM_MAT8 PF02038.14 NM_022004.6_1 - 3.2e-26 90.3 0.2 5.3e-26 89.6 0.2 1.4 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family OTCace PF00185.22 NM_008769.4_1 - 1.5e-51 174.5 0.0 2.2e-51 173.9 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.19 NM_008769.4_1 - 1.8e-41 141.4 0.0 2.6e-41 140.9 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain TM2 PF05154.14 NM_027194.3_3 - 7.2e-15 54.9 12.2 1.8e-14 53.6 12.2 1.7 1 0 0 1 1 1 1 TM2 domain LRR_8 PF13855.4 NM_001012324.2_1 - 2.2e-45 152.1 29.0 1.1e-15 57.0 0.9 6.9 4 2 3 7 7 7 7 Leucine rich repeat LRR_4 PF12799.5 NM_001012324.2_1 - 1.6e-22 79.0 33.0 3.5e-05 23.9 0.9 9.1 6 1 3 9 9 9 7 Leucine Rich repeats (2 copies) VWC PF00093.16 NM_001012324.2_1 - 6.9e-11 42.2 14.1 6.9e-11 42.2 14.1 1.8 2 0 0 2 2 2 1 von Willebrand factor type C domain LRR_5 PF13306.4 NM_001012324.2_1 - 2.1e-10 40.5 3.4 1.6e-05 24.7 0.0 3.6 2 1 0 3 3 3 2 Leucine rich repeats (6 copies) LRR_1 PF00560.31 NM_001012324.2_1 - 0.00011 22.1 39.8 0.18 12.3 0.1 12.4 11 2 1 12 12 12 2 Leucine Rich Repeat FNIP PF05725.10 NM_001012324.2_1 - 0.00055 19.9 4.9 4.5 7.4 0.2 5.0 5 1 1 6 6 6 2 FNIP Repeat LRR_9 PF14580.4 NM_001012324.2_1 - 0.00088 18.7 16.1 1.2 8.5 2.1 4.7 2 2 2 5 5 5 3 Leucine-rich repeat LRR_6 PF13516.4 NM_001012324.2_1 - 0.013 15.4 0.5 0.087 12.8 0.2 7.8 10 0 0 10 10 10 0 Leucine Rich repeat Amnionless PF14828.4 NM_001012324.2_1 - 3.8 6.1 17.5 5.5 5.6 16.6 1.5 1 1 0 1 1 1 0 Amnionless TFIIA PF03153.11 NM_001012324.2_1 - 7.9 6.2 10.0 14 5.4 10.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Xlink PF00193.15 NM_001039151.1_2 - 7.6e-19 67.8 0.0 1.6e-18 66.8 0.0 1.6 1 0 0 1 1 1 1 Extracellular link domain EF-hand_7 PF13499.4 NM_001290690.1_2 - 7.8e-22 77.4 1.3 1e-16 61.0 0.6 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_001290690.1_2 - 6.4e-17 59.6 5.2 1.2e-06 27.5 0.2 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_001290690.1_2 - 4e-13 48.0 5.8 0.0015 18.2 0.1 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 NM_001290690.1_2 - 1.6e-12 46.8 3.1 6.6e-06 25.7 0.1 3.5 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 NM_001290690.1_2 - 1e-11 43.6 1.8 0.00018 20.7 0.2 3.6 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.7 NM_001290690.1_2 - 0.00022 21.4 0.6 0.0069 16.6 0.5 2.4 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.4 NM_001290690.1_2 - 0.037 14.2 0.2 3.9 7.7 0.0 3.1 2 1 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.5 NM_001290690.1_2 - 0.065 13.1 0.3 0.28 11.0 0.2 2.0 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand UCH PF00443.27 NM_001076676.2_1 - 4.4e-64 216.3 0.0 3.5e-63 213.4 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001076676.2_1 - 6.5e-33 114.5 1.3 2.2e-21 76.6 0.0 2.2 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.10 NM_001076676.2_1 - 1.9e-23 82.8 0.1 1.1e-12 48.3 0.0 2.8 2 0 0 2 2 2 2 DUSP domain zf-UBP PF02148.17 NM_001076676.2_1 - 3.8e-16 59.0 7.9 3.8e-16 59.0 7.9 3.5 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein RILP PF11461.6 NM_001076676.2_1 - 0.14 12.3 3.9 0.37 10.9 3.9 1.7 1 0 0 1 1 1 0 Rab interacting lysosomal protein IMD PF08397.9 NM_001310591.1_1 - 4.2e-101 336.8 1.6 5.6e-101 336.4 1.6 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain Sushi PF00084.18 NM_013499.2_2 - 1.5e-48 163.1 22.3 4.4e-11 43.1 0.2 5.5 5 1 0 5 5 5 5 Sushi repeat (SCR repeat) PspB PF06667.10 NM_013499.2_2 - 0.0031 17.4 0.4 0.0062 16.4 0.4 1.4 1 0 0 1 1 1 1 Phage shock protein B DUF1201 PF06716.9 NM_013499.2_2 - 0.014 15.3 0.4 0.014 15.3 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) Rifin_STEVOR PF02009.14 NM_013499.2_2 - 0.025 14.3 0.1 0.038 13.7 0.1 1.2 1 0 0 1 1 1 0 Rifin/stevor family DUF3290 PF11694.6 NM_013499.2_2 - 0.066 13.0 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) ASFV_J13L PF05568.9 NM_013499.2_2 - 0.071 12.7 0.2 0.13 11.9 0.2 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein cEGF PF12662.5 NM_013499.2_2 - 0.18 11.7 9.9 16 5.4 0.0 4.5 4 0 0 4 4 4 0 Complement Clr-like EGF-like Vpu PF00558.17 NM_013499.2_2 - 0.29 10.8 1.5 0.5 10.0 1.5 1.3 1 0 0 1 1 1 0 Vpu protein Adeno_E3_CR2 PF02439.13 NM_013499.2_2 - 0.39 10.4 5.1 0.75 9.5 5.1 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 2OG-FeII_Oxy_3 PF13640.4 NM_025402.2_3 - 1.3e-09 38.7 0.1 2.4e-09 37.8 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pkinase PF00069.23 NM_001271370.1_3 - 1e-49 169.2 0.0 1.8e-49 168.4 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001271370.1_3 - 1.1e-21 77.1 0.0 1.6e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_001271370.1_3 - 0.072 12.9 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Laminin_N PF00055.15 NM_021320.3_1 - 5.4e-67 225.7 0.4 5.4e-67 225.7 0.4 2.1 2 1 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.22 NM_021320.3_1 - 1.9e-26 91.8 62.9 1.2e-10 41.2 6.9 6.4 4 1 1 5 5 5 3 Laminin EGF domain NTR PF01759.19 NM_021320.3_1 - 8.8e-23 80.0 0.7 2.8e-22 78.4 0.1 2.1 2 0 0 2 2 2 1 UNC-6/NTR/C345C module F5_F8_type_C PF00754.23 NM_021320.3_1 - 0.0021 18.1 0.0 0.0039 17.2 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain BNR_6 PF15899.3 NM_021320.3_1 - 0.18 11.9 0.0 0.43 10.7 0.0 1.6 1 0 0 1 1 1 0 BNR-Asp box repeat MITF_TFEB_C_3_N PF15951.3 NM_001105254.1_3 - 0.039 14.4 0.0 0.063 13.8 0.0 1.2 1 0 0 1 1 1 0 MITF/TFEB/TFEC/TFE3 N-terminus LRR_4 PF12799.5 NM_001105254.1_3 - 4.2 7.8 21.3 5.2 7.5 0.2 5.1 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) Cation_efflux PF01545.19 NM_172816.3_1 - 3.5e-44 150.8 16.1 3.5e-44 150.8 16.1 1.9 2 0 0 2 2 2 1 Cation efflux family fn3 PF00041.19 NM_139299.2_2 - 3.6e-18 65.6 13.1 8.8e-07 29.1 0.1 6.1 7 0 0 7 7 7 3 Fibronectin type III domain Tissue_fac PF01108.15 NM_139299.2_2 - 3.8e-05 23.3 5.1 0.58 9.9 0.0 4.8 5 0 0 5 5 5 2 Tissue factor EpoR_lig-bind PF09067.8 NM_139299.2_2 - 0.007 16.4 0.4 0.022 14.8 0.4 1.8 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.8 NM_139299.2_2 - 0.012 15.8 0.5 0.34 11.2 0.2 2.8 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding Ribosomal_L22e PF01776.15 NM_001277114.1_2 - 5.6e-21 74.8 3.0 8.8e-21 74.2 3.0 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family Ribosomal_L22e PF01776.15 NM_001277114.1_3 - 3.4e-22 78.8 0.0 5.5e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family Laminin_G_2 PF02210.22 NM_172544.3_1 - 1.5e-129 426.2 10.6 4.3e-28 98.3 0.0 5.3 5 0 0 5 5 5 5 Laminin G domain Laminin_G_1 PF00054.21 NM_172544.3_1 - 1.4e-91 303.4 6.9 6.6e-25 87.7 0.0 5.8 6 0 0 6 6 6 5 Laminin G domain Laminin_G_3 PF13385.4 NM_172544.3_1 - 5.6e-20 71.9 6.9 0.00024 21.1 0.1 5.7 5 0 0 5 5 5 5 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 NM_172544.3_1 - 1.4e-07 31.5 19.1 0.00013 22.0 6.2 3.0 2 0 0 2 2 2 2 EGF-like domain Syndecan PF01034.18 NM_172544.3_1 - 2.9e-07 30.1 0.0 7e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 Syndecan domain DUF1080 PF06439.9 NM_172544.3_1 - 3.2e-05 24.0 0.1 3.6 7.5 0.0 4.5 4 0 0 4 4 4 2 Domain of Unknown Function (DUF1080) hEGF PF12661.5 NM_172544.3_1 - 0.0033 17.9 12.2 0.35 11.5 2.8 3.1 2 0 0 2 2 2 2 Human growth factor-like EGF DUF202 PF02656.13 NM_172544.3_1 - 0.096 13.0 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) COX14 PF14880.4 NM_172544.3_1 - 0.14 11.9 1.6 2.3 8.0 0.2 2.7 2 0 0 2 2 2 0 Cytochrome oxidase c assembly Holin_BhlA PF10960.6 NM_172544.3_1 - 0.44 10.4 2.6 24 4.9 1.3 2.5 2 0 0 2 2 2 0 BhlA holin family RasGEF PF00617.17 NM_001252494.1_2 - 1.8e-51 174.6 0.2 3.4e-51 173.7 0.2 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 NM_001252494.1_2 - 1.4e-12 47.7 0.7 2.4e-11 43.7 0.7 2.5 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 NM_001252494.1_2 - 3.4e-12 46.7 0.0 8.8e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ PF00595.22 NM_001252494.1_2 - 9.4e-12 45.0 0.0 2.5e-11 43.7 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) cNMP_binding PF00027.27 NM_001252494.1_2 - 1.7e-11 43.9 0.0 7.4e-08 32.2 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_2 PF13180.4 NM_001252494.1_2 - 0.00018 21.7 0.0 0.00044 20.4 0.0 1.6 1 0 0 1 1 1 1 PDZ domain START PF01852.17 NM_001194940.2_1 - 8.4e-51 172.2 0.1 1.4e-50 171.5 0.1 1.4 1 0 0 1 1 1 1 START domain RhoGAP PF00620.25 NM_001194940.2_1 - 4e-41 140.2 0.9 1.2e-40 138.7 0.9 1.9 2 0 0 2 2 2 1 RhoGAP domain SAM_2 PF07647.15 NM_001194940.2_1 - 9.1e-06 25.6 0.0 2.6e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4561 PF15120.4 NM_001194940.2_1 - 0.5 10.0 3.4 2.3 7.8 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4561) Septin PF00735.16 NM_001310671.1_3 - 1.3e-97 326.3 1.2 2.1e-97 325.6 1.2 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 NM_001310671.1_3 - 3.5e-06 27.0 0.0 7.5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.11 NM_001310671.1_3 - 0.0052 16.9 0.0 0.0099 16.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_001310671.1_3 - 0.0085 16.4 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 NM_001310671.1_3 - 0.011 15.8 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF3080 PF11279.6 NM_001310671.1_3 - 0.018 14.1 6.3 0.028 13.5 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3080) Ras PF00071.20 NM_001310671.1_3 - 0.033 13.7 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 Ras family AAA_29 PF13555.4 NM_001310671.1_3 - 0.098 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.4 NM_001310671.1_3 - 0.37 11.1 19.3 1 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.14 NM_001310671.1_3 - 2.9 7.6 5.3 1.5 8.5 0.0 2.4 3 0 0 3 3 2 0 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_001310671.1_3 - 5.3 6.4 8.2 9.2 5.6 0.2 2.7 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Atg14 PF10186.7 NM_001310671.1_3 - 6.5 5.6 17.2 11 4.8 17.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fzo_mitofusin PF04799.11 NM_001310671.1_3 - 9.3 5.6 9.0 18 4.7 9.0 1.3 1 0 0 1 1 1 0 fzo-like conserved region Ras PF00071.20 NM_001243769.1_3 - 2.8e-52 176.4 0.0 3.5e-52 176.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001243769.1_3 - 6.3e-19 68.2 0.0 9.5e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001243769.1_3 - 2.2e-07 30.4 0.0 3.4e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PET117 PF15786.3 NM_001243769.1_3 - 0.0014 18.7 0.0 0.0024 18.0 0.0 1.3 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial GTP_EFTU PF00009.25 NM_001243769.1_3 - 0.18 11.2 0.0 0.62 9.4 0.0 1.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Alveol-reg_P311 PF11092.6 NM_001109989.2_3 - 6.9e-33 112.5 0.0 1.1e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 Neuronal protein 3.1 (p311) Ion_trans_N PF08412.8 NM_010408.3_1 - 1.7e-20 72.2 0.1 3.2e-20 71.3 0.1 1.5 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.27 NM_010408.3_1 - 3.9e-17 61.9 0.0 6.5e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 NM_010408.3_1 - 0.012 15.4 0.1 0.04 13.8 0.1 1.9 1 0 0 1 1 1 0 Ion channel Peptidase_S49_N PF08496.8 NM_010408.3_1 - 0.054 13.4 5.4 0.11 12.4 5.4 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4746 PF15928.3 NM_010408.3_1 - 0.12 11.7 6.3 0.29 10.4 6.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) UPF0560 PF10577.7 NM_010408.3_1 - 0.14 10.5 21.6 0.2 10.0 21.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DDHD PF02862.15 NM_010408.3_1 - 0.14 12.1 12.7 0.24 11.3 12.7 1.3 1 0 0 1 1 1 0 DDHD domain YABBY PF04690.11 NM_010408.3_1 - 0.15 12.5 14.0 0.31 11.5 14.0 1.4 1 0 0 1 1 1 0 YABBY protein TFIIA PF03153.11 NM_010408.3_1 - 0.19 11.5 57.0 0.3 10.9 57.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.7 NM_010408.3_1 - 0.23 9.6 34.7 0.36 8.9 34.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EPL1 PF10513.7 NM_010408.3_1 - 0.37 11.0 14.4 0.84 9.9 14.4 1.5 1 0 0 1 1 1 0 Enhancer of polycomb-like Hamartin PF04388.10 NM_010408.3_1 - 0.39 9.2 25.7 0.55 8.7 25.7 1.1 1 0 0 1 1 1 0 Hamartin protein Het-C PF07217.9 NM_010408.3_1 - 1.9 6.8 9.6 2.8 6.2 9.6 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Nucleo_P87 PF07267.9 NM_010408.3_1 - 2.1 7.0 17.2 3.3 6.3 17.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 eIF-3_zeta PF05091.10 NM_010408.3_1 - 2.3 7.0 23.0 4 6.2 23.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1387 PF07139.9 NM_010408.3_1 - 2.8 7.4 19.0 4.4 6.8 19.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Tim54 PF11711.6 NM_010408.3_1 - 5.3 5.6 19.6 8.9 4.8 19.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SpoIIP PF07454.9 NM_010408.3_1 - 9.3 5.5 21.0 15 4.8 21.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Secretin_N_2 PF07655.11 NM_010408.3_2 - 9.1 6.8 20.9 18 5.8 20.9 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain DUF3337 PF11816.6 NM_026236.3_1 - 6.9e-47 159.2 0.2 1.5e-46 158.1 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.30 NM_026236.3_1 - 1e-26 92.5 11.6 5.3e-05 23.8 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_026236.3_1 - 5.3e-06 26.5 2.5 0.094 12.9 0.2 3.7 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain RAWUL PF16207.3 NM_026236.3_1 - 0.012 16.1 0.0 0.025 15.1 0.0 1.5 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like Nucleoporin_N PF08801.9 NM_026236.3_1 - 0.02 13.6 0.3 1.3 7.6 0.0 2.7 1 1 2 3 3 3 0 Nup133 N terminal like WD40_like PF17005.3 NM_026236.3_1 - 0.049 12.8 0.0 0.092 11.9 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain CXCXC PF03128.12 NM_026236.3_1 - 0.27 11.6 4.3 9.2 6.8 0.0 3.6 2 0 0 2 2 2 0 CXCXC repeat Nup160 PF11715.6 NM_026236.3_1 - 0.41 9.1 6.8 1.8 7.0 0.7 3.5 2 1 2 4 4 4 0 Nucleoporin Nup120/160 REPA_OB_2 PF16900.3 NM_175326.5_1 - 0.018 14.9 0.0 0.13 12.0 0.0 2.3 2 0 0 2 2 2 0 Replication protein A OB domain BRCA-2_OB1 PF09103.8 NM_175326.5_1 - 0.021 14.6 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Kelch_1 PF01344.23 NM_001160178.1_1 - 5.9e-27 92.9 14.0 1e-09 37.7 0.1 6.3 6 2 0 6 6 6 4 Kelch motif Kelch_6 PF13964.4 NM_001160178.1_1 - 4.2e-23 80.7 5.1 1.7e-05 24.8 0.0 6.1 2 2 4 6 6 6 5 Kelch motif Kelch_4 PF13418.4 NM_001160178.1_1 - 1.8e-10 40.5 6.1 0.0092 15.8 0.0 5.8 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.4 NM_001160178.1_1 - 2.2e-08 34.0 3.2 0.0032 17.6 0.0 5.5 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_001160178.1_1 - 1.7e-07 30.8 0.1 0.51 10.3 0.0 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.4 NM_001160178.1_1 - 0.013 15.3 0.2 6 6.8 0.2 3.4 3 0 0 3 3 3 0 Kelch motif IIGP PF05049.11 NM_001114679.1_3 - 6.1e-276 914.0 0.4 7.9e-151 502.2 0.0 2.2 2 0 0 2 2 2 2 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.21 NM_001114679.1_3 - 2.1e-19 69.5 0.0 1.6e-10 40.9 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Transposase_22 PF02994.12 NM_001114679.1_3 - 1.5e-12 46.9 0.8 1.5e-12 46.9 0.8 2.0 2 0 0 2 2 1 1 L1 transposable element Dynamin_N PF00350.21 NM_001114679.1_3 - 6.9e-12 45.6 1.1 0.018 15.0 0.1 4.6 2 2 2 4 4 4 2 Dynamin family DUF258 PF03193.14 NM_001114679.1_3 - 1.2e-10 41.4 0.6 1.7e-05 24.7 0.1 2.9 2 0 0 2 2 2 2 Protein of unknown function, DUF258 ABC_tran PF00005.25 NM_001114679.1_3 - 5.7e-10 39.7 0.0 0.00036 20.9 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.4 NM_001114679.1_3 - 6.9e-09 36.2 0.2 0.0091 16.3 0.0 3.7 2 2 0 2 2 2 2 AAA ATPase domain FeoB_N PF02421.16 NM_001114679.1_3 - 1.6e-07 30.9 0.0 0.019 14.4 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B AAA_29 PF13555.4 NM_001114679.1_3 - 1.4e-06 27.7 0.9 0.046 13.3 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AIG1 PF04548.14 NM_001114679.1_3 - 7.2e-06 25.3 0.0 0.082 12.1 0.0 2.5 2 0 0 2 2 2 2 AIG1 family Roc PF08477.11 NM_001114679.1_3 - 1.5e-05 25.1 0.0 0.24 11.5 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.4 NM_001114679.1_3 - 2.3e-05 24.6 0.0 0.22 11.7 0.0 3.0 2 0 0 2 2 2 2 AAA domain DLIC PF05783.9 NM_001114679.1_3 - 3.7e-05 22.6 0.5 0.04 12.6 0.1 2.3 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) Sigma54_activat PF00158.24 NM_001114679.1_3 - 8.6e-05 22.2 0.4 0.083 12.5 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain FtsK_SpoIIIE PF01580.16 NM_001114679.1_3 - 0.00024 20.4 0.7 0.23 10.7 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family Sigma54_activ_2 PF14532.4 NM_001114679.1_3 - 0.00062 19.8 0.1 1.2 9.1 0.0 3.6 4 0 0 4 4 4 1 Sigma-54 interaction domain T2SSE PF00437.18 NM_001114679.1_3 - 0.00067 18.7 0.2 0.13 11.1 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein KAP_NTPase PF07693.12 NM_001114679.1_3 - 0.0009 18.4 0.0 0.19 10.8 0.0 2.4 2 0 0 2 2 2 1 KAP family P-loop domain Septin PF00735.16 NM_001114679.1_3 - 0.0011 18.1 0.1 1.2 8.2 0.0 2.4 2 0 0 2 2 2 2 Septin AAA_21 PF13304.4 NM_001114679.1_3 - 0.0017 18.1 0.7 2.5 7.7 0.0 3.3 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF815 PF05673.11 NM_001114679.1_3 - 0.0029 16.7 0.1 2.1 7.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) RNA_helicase PF00910.20 NM_001114679.1_3 - 0.0029 17.8 0.0 1.2 9.5 0.0 2.7 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.15 NM_001114679.1_3 - 0.0044 16.7 0.1 2.7 7.6 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_24 PF13479.4 NM_001114679.1_3 - 0.0074 15.9 0.1 3 7.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 NM_001114679.1_3 - 0.011 15.3 0.8 0.5 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma70_r4 PF04545.14 NM_001114679.1_3 - 0.018 14.4 0.0 5.9 6.4 0.0 2.7 2 0 0 2 2 2 0 Sigma-70, region 4 AAA_23 PF13476.4 NM_001114679.1_3 - 0.02 15.3 12.5 0.67 10.3 0.0 4.0 3 1 1 4 4 3 0 AAA domain SMC_N PF02463.17 NM_001114679.1_3 - 0.031 13.6 0.1 7.2 5.8 0.0 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain DUF87 PF01935.15 NM_001114679.1_3 - 0.033 14.1 4.4 4.5 7.1 0.1 3.6 4 0 0 4 4 3 0 Domain of unknown function DUF87 PI-PLC-C1 PF16670.3 NM_001114679.1_3 - 0.063 12.2 0.8 4.8 6.0 0.1 2.4 2 0 0 2 2 2 0 Phosphoinositide phospholipase C, Ca2+-dependent AAA_18 PF13238.4 NM_001114679.1_3 - 0.11 12.9 1.6 13 6.2 0.1 2.8 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 NM_001114679.1_3 - 0.13 11.4 4.4 1.6 7.9 0.2 2.8 3 0 0 3 3 3 0 Zeta toxin DUF2316 PF10078.7 NM_001114679.1_3 - 0.15 12.3 0.3 5.6 7.2 0.0 3.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) AAA_10 PF12846.5 NM_001114679.1_3 - 0.18 10.6 2.4 6.7 5.4 0.2 2.7 3 0 0 3 3 3 0 AAA-like domain PRK PF00485.16 NM_001114679.1_3 - 0.31 10.6 1.1 15 5.1 0.1 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.4 NM_001114679.1_3 - 0.31 11.1 1.8 22 5.1 0.1 2.6 2 0 0 2 2 2 0 AAA domain UPF0122 PF04297.12 NM_001114679.1_3 - 0.43 10.7 2.4 26 5.0 0.3 2.6 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like DUF4795 PF16043.3 NM_001114679.1_3 - 2.4 7.5 7.1 3 7.2 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4795) HLH PF00010.24 NM_024469.2_1 - 4.2e-11 42.5 1.4 7.7e-11 41.7 1.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.11 NM_024469.2_1 - 1.1e-09 38.2 0.3 2.7e-09 36.9 0.3 1.7 1 0 0 1 1 1 1 Hairy Orange Ig_2 PF13895.4 NM_175632.3_3 - 6.5e-14 51.9 0.0 1.1e-08 35.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_175632.3_3 - 0.0002 21.8 0.0 0.011 16.2 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 NM_175632.3_3 - 0.00036 20.5 0.1 0.16 12.0 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin domain GSDH PF07995.9 NM_001308052.1_3 - 7e-38 130.6 0.0 9.6e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Folate_rec PF03024.12 NM_001308052.1_3 - 3.5e-06 26.9 0.5 6.2e-06 26.1 0.5 1.4 1 0 0 1 1 1 1 Folate receptor family PMT PF02366.16 NM_153415.4_2 - 8.7e-88 293.9 16.2 1.3e-87 293.3 16.2 1.3 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.3 NM_153415.4_2 - 1.6e-54 184.4 3.2 1.6e-54 184.4 3.2 1.8 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.17 NM_153415.4_2 - 1.9e-22 79.9 0.1 3.2e-22 79.1 0.1 1.2 1 0 0 1 1 1 1 MIR domain MYT1 PF08474.9 NM_001093775.1_1 - 4e-119 396.7 9.1 4e-119 396.7 9.1 2.8 2 1 0 2 2 2 1 Myelin transcription factor 1 zf-C2HC PF01530.16 NM_001093775.1_1 - 7.2e-84 275.4 88.3 2.5e-15 56.2 7.2 7.7 7 0 0 7 7 7 6 Zinc finger, C2HC type DUF342 PF03961.11 NM_001093775.1_1 - 0.056 11.9 7.3 0.1 11.1 7.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DivIC PF04977.13 NM_001093775.1_1 - 0.82 9.4 12.5 1.2 8.8 2.8 2.5 1 1 1 2 2 2 0 Septum formation initiator bZIP_1 PF00170.19 NM_001093775.1_1 - 9.3 6.3 12.0 4.1 7.4 3.6 2.9 1 1 1 2 2 2 0 bZIP transcription factor zf-DHHC PF01529.18 NM_172151.4_1 - 2.4e-34 118.2 8.9 2.4e-34 118.2 8.9 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase Histone_H2A_C PF16211.3 NM_175658.2_1 - 2.1e-20 72.0 0.9 2.1e-20 72.0 0.9 1.7 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.22 NM_175658.2_1 - 2.5e-18 66.6 0.0 3.6e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_175658.2_1 - 4.2e-06 26.8 0.0 5.8e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Laminin_G_2 PF02210.22 NM_020252.3_1 - 9.1e-155 507.7 6.6 8.4e-28 97.3 0.0 6.3 6 0 0 6 6 6 6 Laminin G domain Laminin_G_1 PF00054.21 NM_020252.3_1 - 4e-104 344.0 0.7 2.9e-24 85.6 0.0 6.4 6 0 0 6 6 6 6 Laminin G domain Laminin_G_3 PF13385.4 NM_020252.3_1 - 7.4e-19 68.3 4.9 0.057 13.4 0.1 6.7 7 0 0 7 7 7 6 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 NM_020252.3_1 - 6.4e-11 42.2 27.2 2.7e-05 24.2 6.8 3.7 3 0 0 3 3 3 3 EGF-like domain Syndecan PF01034.18 NM_020252.3_1 - 5.4e-07 29.3 0.0 1.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Syndecan domain hEGF PF12661.5 NM_020252.3_1 - 0.0049 17.4 26.6 0.22 12.1 4.8 4.1 3 0 0 3 3 3 2 Human growth factor-like EGF DUF1080 PF06439.9 NM_020252.3_1 - 0.023 14.7 0.0 21 5.0 0.0 3.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1080) DUF202 PF02656.13 NM_020252.3_1 - 0.15 12.4 0.0 0.31 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF202) RhoGAP PF00620.25 NM_001166064.1_1 - 2.9e-45 153.6 0.1 5.2e-45 152.9 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain VOMI PF03762.15 NM_001013607.1_3 - 1.3e-61 207.4 0.5 1.6e-61 207.2 0.5 1.1 1 0 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) Spectrin PF00435.19 NM_013456.2_2 - 6.4e-72 238.6 23.8 1.1e-23 83.6 9.2 4.3 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.29 NM_013456.2_2 - 9.5e-56 186.5 0.1 6.2e-29 100.2 0.0 2.9 2 0 0 2 2 2 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.8 NM_013456.2_2 - 1e-25 89.5 0.0 3.9e-25 87.6 0.0 2.1 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.6 NM_013456.2_2 - 3.2e-10 39.6 0.0 7.6e-09 35.2 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_1 PF00036.30 NM_013456.2_2 - 9.1e-07 27.9 0.2 0.0097 15.3 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 NM_013456.2_2 - 7.6e-06 26.2 0.1 5.2e-05 23.5 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_013456.2_2 - 0.00012 21.6 0.0 0.024 14.4 0.0 3.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.4 NM_013456.2_2 - 0.0036 16.9 1.0 0.3 10.7 0.3 3.6 3 1 1 4 4 4 1 EF-hand domain pair BLOC1_2 PF10046.7 NM_013456.2_2 - 0.5 10.6 5.7 7.3 6.9 0.1 3.8 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Serpin PF00079.18 NM_011458.2_3 - 1.2e-119 399.8 2.6 1.5e-119 399.5 2.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF531 PF04407.10 NM_011458.2_3 - 0.0016 18.4 0.1 0.0045 17.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF531) KRAB PF01352.25 NM_001205057.2_1 - 2.1e-20 72.0 0.1 3.5e-20 71.3 0.1 1.4 1 0 0 1 1 1 1 KRAB box AgrD PF05931.9 NM_001205057.2_1 - 0.069 13.1 0.8 0.14 12.1 0.8 1.5 1 0 0 1 1 1 0 Staphylococcal AgrD protein Dus PF01207.15 NM_144858.2_1 - 3.9e-57 193.5 0.0 5.6e-57 193.1 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH PF00642.22 NM_144858.2_1 - 0.00018 21.2 11.5 0.00064 19.4 0.1 3.6 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 NM_144858.2_1 - 6.4 7.3 6.5 1.6 9.1 0.2 3.1 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger TNF PF00229.16 NM_026125.3_1 - 0.00043 20.1 0.1 0.054 13.3 0.1 2.2 2 0 0 2 2 2 2 TNF(Tumour Necrosis Factor) family C1q PF00386.19 NM_026125.3_1 - 0.0049 17.0 0.1 0.11 12.5 0.1 2.2 1 1 0 1 1 1 1 C1q domain Collagen PF01391.16 NM_026125.3_1 - 0.007 16.0 8.8 0.017 14.7 8.8 1.6 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) TF_Otx PF03529.11 NM_001286483.1_2 - 6.2e-32 109.7 14.7 6.2e-32 109.7 14.7 2.4 2 1 1 3 3 3 1 Otx1 transcription factor Homeobox PF00046.27 NM_001286483.1_2 - 1.8e-21 75.5 2.2 3.1e-21 74.8 2.2 1.4 1 0 0 1 1 1 1 Homeobox domain NUDE_C PF04880.11 NM_001286483.1_2 - 0.3 11.4 4.4 0.58 10.5 4.4 1.4 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Abhydrolase_3 PF07859.11 NM_001085542.1_1 - 3.1e-43 147.9 0.1 2.6e-31 109.0 0.2 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.26 NM_001085542.1_1 - 0.0009 18.1 0.3 0.0047 15.8 0.3 1.9 1 1 0 1 1 1 1 Carboxylesterase family Lipase_3 PF01764.23 NM_001085542.1_1 - 0.034 13.9 0.0 0.055 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Esterase_phd PF10503.7 NM_001085542.1_1 - 0.11 11.8 0.1 0.19 11.1 0.1 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase Iso_dh PF00180.18 NM_130884.4_2 - 4.5e-76 256.1 0.3 5.5e-76 255.8 0.3 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase AAA_3 PF07726.9 NM_130884.4_2 - 0.056 13.2 0.0 0.097 12.4 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TRAM_LAG1_CLN8 PF03798.14 NM_001291156.1_3 - 4.3e-15 55.9 4.1 6e-15 55.4 4.1 1.2 1 0 0 1 1 1 1 TLC domain Phage_holin_3_3 PF16083.3 NM_001291156.1_3 - 0.014 15.5 0.0 8.3 6.5 0.0 2.5 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III SBF PF01758.14 NM_011388.3_3 - 8.1e-44 149.5 17.6 8.1e-44 149.5 17.6 2.0 2 0 0 2 2 2 1 Sodium Bile acid symporter family T-box PF00907.20 NM_011532.2_1 - 5.4e-80 267.8 0.1 6.9e-80 267.5 0.1 1.1 1 0 0 1 1 1 1 T-box Transport_MerF PF11431.6 NM_001289711.1_1 - 0.061 13.1 0.3 0.11 12.3 0.3 1.3 1 0 0 1 1 1 0 Membrane transport protein MerF MBT PF02820.16 NM_001289711.1_2 - 3.7e-97 318.6 3.4 3.5e-28 97.6 0.2 4.5 4 0 0 4 4 4 4 mbt repeat Agenet PF05641.10 NM_001289711.1_2 - 0.05 14.0 0.0 0.18 12.2 0.0 2.0 1 0 0 1 1 1 0 Agenet domain UDPGP PF01704.16 NM_001290634.1_1 - 4.5e-198 657.9 0.1 5.3e-198 657.6 0.1 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Zip PF02535.20 NM_001039676.2_2 - 3.1e-57 194.2 18.8 6.7e-56 189.8 18.8 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter Radial_spoke PF04712.10 NM_029338.3_3 - 1.3e-13 50.6 0.0 2.3e-06 26.7 0.0 2.3 2 0 0 2 2 2 2 Radial spokehead-like protein Ribosomal_L34 PF00468.15 NM_053162.2_3 - 2.4e-17 62.5 1.5 4.6e-17 61.6 1.5 1.5 1 0 0 1 1 1 1 Ribosomal protein L34 7tm_4 PF13853.4 NM_146399.2_1 - 1.3e-52 179.2 18.4 1.5e-52 178.9 18.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146399.2_1 - 8.6e-26 90.6 24.7 1.7e-25 89.7 24.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146399.2_1 - 1.2e-06 28.0 21.0 2.1e-06 27.2 21.0 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Glycoprotein_G PF00802.17 NM_146399.2_1 - 0.2 10.9 1.4 0.3 10.3 1.4 1.2 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G NAAA-beta PF15508.4 NM_025972.4_2 - 8.3e-15 54.7 0.0 1.4e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase CBAH PF02275.16 NM_025972.4_2 - 2.9e-08 33.6 0.0 1.8e-06 27.7 0.0 2.2 1 1 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family MPC PF03650.11 NM_001101484.1_1 - 1.4e-30 105.6 0.0 2.1e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) ECR1_N PF14382.4 NM_001320232.1_3 - 1.6e-08 34.0 0.0 4.4e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.7 NM_001320232.1_3 - 1.4e-05 25.6 0.4 0.0029 18.2 0.1 2.2 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 F5_F8_type_C PF00754.23 NM_001037987.3_1 - 5.5e-61 204.2 4.7 3.3e-31 107.9 0.7 2.2 2 0 0 2 2 2 2 F5/8 type C domain EGF PF00008.25 NM_001037987.3_1 - 4.5e-15 55.5 51.9 7.5e-09 35.6 7.7 5.4 5 0 0 5 5 5 3 EGF-like domain hEGF PF12661.5 NM_001037987.3_1 - 6.7e-08 32.8 36.6 0.0022 18.5 4.5 6.3 4 1 0 4 4 4 3 Human growth factor-like EGF EGF_2 PF07974.11 NM_001037987.3_1 - 0.014 15.6 47.3 0.1 12.9 8.3 4.9 4 0 0 4 4 4 0 EGF-like domain zf-C2H2 PF00096.24 NM_008453.5_3 - 4.2e-15 55.1 23.0 4.7e-06 26.6 2.7 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_008453.5_3 - 1.6e-11 44.0 8.8 9.9e-09 35.1 1.1 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_008453.5_3 - 1.3e-07 31.7 20.0 0.0054 17.3 1.9 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.5 NM_008453.5_3 - 0.014 15.7 5.2 0.87 9.9 0.3 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 NM_008453.5_3 - 0.081 12.8 8.5 0.086 12.7 0.5 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_008453.5_3 - 0.79 10.0 3.8 23 5.3 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding 7tm_4 PF13853.4 NM_207695.1_1 - 3.2e-47 161.5 19.8 3.9e-47 161.2 19.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207695.1_1 - 1.9e-28 99.3 18.5 4.3e-28 98.2 18.5 1.6 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_207695.1_1 - 2.6e-06 26.9 16.4 3.5e-06 26.4 16.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Cyt-b5 PF00173.26 NM_001045525.1_3 - 4.8e-08 32.9 0.0 1e-07 31.8 0.0 1.7 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Rad60-SLD PF11976.6 NM_001045525.1_3 - 0.0097 15.6 0.0 0.025 14.3 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Collagen PF01391.16 NM_130449.2_1 - 3.9e-24 84.1 97.4 2.5e-09 36.6 29.9 3.3 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Lectin_C PF00059.19 NM_130449.2_1 - 8.9e-23 81.0 3.0 2.8e-22 79.4 3.0 1.9 1 0 0 1 1 1 1 Lectin C-type domain Filament PF00038.19 NM_130449.2_1 - 0.00049 19.6 24.6 0.00049 19.6 24.6 2.1 1 1 1 2 2 2 1 Intermediate filament protein Reo_sigmaC PF04582.10 NM_130449.2_1 - 0.0045 16.3 37.8 0.049 12.9 8.1 3.2 1 1 2 3 3 3 2 Reovirus sigma C capsid protein IncA PF04156.12 NM_130449.2_1 - 0.024 14.3 26.8 0.92 9.1 17.2 3.5 2 1 0 2 2 2 0 IncA protein Spc7 PF08317.9 NM_130449.2_1 - 0.19 10.4 30.4 0.46 9.2 9.1 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Alpha-2-MRAP_C PF06401.9 NM_130449.2_1 - 0.64 9.8 20.4 0.061 13.1 9.7 2.3 1 1 0 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain Golgin_A5 PF09787.7 NM_130449.2_1 - 0.7 9.2 34.0 0.8 9.0 8.0 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 Tropomyosin PF00261.18 NM_130449.2_1 - 0.97 8.6 15.6 0.85 8.8 3.3 2.4 2 1 0 2 2 2 0 Tropomyosin Fib_alpha PF08702.8 NM_130449.2_1 - 1.8 8.6 38.2 0.11 12.6 4.9 4.2 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Atg14 PF10186.7 NM_130449.2_1 - 4.3 6.2 28.8 0.73 8.7 8.2 2.9 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4208 PF13907.4 NM_130449.2_1 - 7.7 6.9 7.5 1.6 9.1 1.1 3.0 2 1 2 4 4 4 0 Domain of unknown function (DUF4208) Sterol-sensing PF12349.6 NM_001103162.2_1 - 6.3e-53 178.6 4.4 1.1e-52 177.8 4.4 1.3 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.16 NM_001103162.2_1 - 1.4e-20 72.9 0.7 2e-20 72.4 0.7 1.1 1 0 0 1 1 1 1 Patched family WD40 PF00400.30 NM_001103162.2_1 - 8.4e-10 39.0 19.8 0.00052 20.6 0.2 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001103162.2_1 - 0.00063 19.9 0.0 0.53 10.5 0.0 3.6 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.9 NM_001103162.2_1 - 0.055 12.4 0.0 4.5 6.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) Cullin_binding PF03556.13 NM_001205361.1_3 - 1.2e-35 122.3 0.7 1.2e-35 122.3 0.7 1.6 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.4 NM_001205361.1_3 - 1.7e-09 37.2 0.1 3.7e-09 36.1 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain Tropomyosin PF00261.18 NM_009416.4_3 - 1e-96 322.8 87.2 1.8e-94 315.5 60.3 2.1 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 NM_009416.4_3 - 7.4e-38 129.8 73.9 2.2e-34 118.5 44.6 3.2 1 1 0 2 2 2 2 Tropomyosin like CLZ PF16526.3 NM_009416.4_3 - 5e-06 26.6 43.1 0.00014 22.0 10.2 4.6 3 2 1 4 4 4 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.10 NM_009416.4_3 - 0.00026 20.9 34.4 0.0025 17.7 6.1 3.2 1 1 2 3 3 3 2 Laminin Domain II YscO PF07321.10 NM_009416.4_3 - 0.0083 16.0 3.9 0.0083 16.0 3.9 4.2 1 1 3 4 4 4 1 Type III secretion protein YscO SlyX PF04102.10 NM_009416.4_3 - 0.08 13.4 0.4 0.08 13.4 0.4 5.3 1 1 3 5 5 5 0 SlyX Reo_sigmaC PF04582.10 NM_009416.4_3 - 0.091 12.0 7.1 0.88 8.8 0.6 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.7 NM_009416.4_3 - 0.16 11.9 65.5 0.25 11.2 28.6 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.17 NM_009416.4_3 - 0.23 11.1 72.1 1.4 8.5 14.1 2.9 1 1 2 3 3 3 0 Ezrin/radixin/moesin family SNARE PF05739.17 NM_009416.4_3 - 0.83 9.6 7.7 8 6.4 0.1 3.4 3 0 0 3 3 3 0 SNARE domain IncA PF04156.12 NM_009416.4_3 - 1.3 8.6 59.7 0.9 9.2 27.3 3.1 1 1 1 2 2 1 0 IncA protein Baculo_PEP_C PF04513.10 NM_009416.4_3 - 1.3 8.9 8.7 4.9 7.1 2.4 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ATG16 PF08614.9 NM_009416.4_3 - 2.2 8.3 62.8 0.038 14.0 22.4 3.3 1 1 2 3 3 2 0 Autophagy protein 16 (ATG16) MscS_porin PF12795.5 NM_009416.4_3 - 2.3 7.5 45.1 15 4.9 29.3 2.7 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Golgin_A5 PF09787.7 NM_009416.4_3 - 3.2 7.0 55.2 1.3 8.3 17.2 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF1664 PF07889.10 NM_009416.4_3 - 7.6 6.4 28.9 0.3 10.9 7.9 3.4 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) HrpB7 PF09486.8 NM_009416.4_3 - 8.9 6.6 48.5 37 4.5 1.3 4.3 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) Sad1_UNC PF07738.11 NM_001205345.1_1 - 8.8e-47 158.4 0.0 1.6e-46 157.5 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal MRP PF09387.8 NM_001205345.1_1 - 0.0024 17.7 2.5 0.0034 17.3 1.4 1.6 1 1 0 1 1 1 1 Mitochondrial RNA binding protein MRP SHE3 PF17078.3 NM_001205345.1_1 - 0.22 11.1 5.7 0.6 9.6 2.2 2.0 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 FAM76 PF16046.3 NM_001205345.1_1 - 3 7.0 5.7 6.7 5.8 5.7 1.6 1 0 0 1 1 1 0 FAM76 protein KH_1 PF00013.27 NM_001301364.1_3 - 1.3e-183 595.0 58.9 3.5e-15 55.4 0.8 15.9 15 1 0 15 15 15 15 KH domain SLS PF14611.4 NM_001301364.1_3 - 1e-18 67.9 15.8 3.3e-05 23.7 0.4 8.5 4 2 4 8 8 8 6 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.15 NM_001301364.1_3 - 3e-14 52.5 40.2 0.0071 16.0 0.2 12.2 12 1 1 13 13 13 7 KH domain KH_5 PF13184.4 NM_001301364.1_3 - 1.2e-06 28.4 22.1 1.9 8.5 0.3 10.0 11 0 0 11 11 11 3 NusA-like KH domain DUF4530 PF15039.4 NM_001301364.1_3 - 0.055 13.5 0.0 18 5.4 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4530) DUF2096 PF09869.7 NM_001301364.1_3 - 2.6 8.0 16.1 10 6.0 0.4 6.1 6 2 0 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2096) DUF2067 PF09840.7 NM_001301364.1_3 - 4.3 6.8 12.0 0.33 10.4 0.2 4.4 6 0 0 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2067) 7tm_4 PF13853.4 NM_146541.2_1 - 2.2e-51 175.1 11.0 2.7e-51 174.8 11.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146541.2_1 - 4.3e-25 88.3 13.4 4.3e-25 88.3 13.4 1.7 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 NM_146541.2_1 - 1.7e-08 34.0 15.4 3.5e-08 33.0 15.4 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 NM_146541.2_1 - 0.00031 20.1 2.7 0.00031 20.1 2.7 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx TNFR_c6 PF00020.16 NM_001271758.1_1 - 5.7 7.3 11.6 1.2 9.5 0.5 3.6 3 1 0 3 3 3 0 TNFR/NGFR cysteine-rich region wnt PF00110.17 NM_001271758.1_3 - 2e-119 398.5 22.3 2.5e-119 398.2 22.3 1.1 1 0 0 1 1 1 1 wnt family SEA PF01390.18 NM_013605.2_2 - 2.2e-11 43.8 1.1 5.6e-11 42.5 1.1 1.7 1 0 0 1 1 1 1 SEA domain DUF4381 PF14316.4 NM_013605.2_2 - 0.14 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) bZIP_Maf PF03131.15 NM_008736.3_1 - 4e-30 104.0 11.5 6e-30 103.5 11.5 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Maf_N PF08383.9 NM_008736.3_1 - 1e-14 53.8 3.3 2.4e-14 52.7 3.3 1.6 1 0 0 1 1 1 1 Maf N-terminal region DivIC PF04977.13 NM_008736.3_1 - 0.038 13.6 0.8 0.073 12.7 0.8 1.4 1 0 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.19 NM_008736.3_1 - 0.1 12.6 13.0 0.17 11.9 13.0 1.3 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.13 NM_008736.3_1 - 0.17 11.8 14.2 0.33 10.9 14.2 1.4 1 0 0 1 1 1 0 Basic region leucine zipper DUF4164 PF13747.4 NM_008736.3_1 - 0.21 11.8 5.4 0.35 11.0 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) SHR3_chaperone PF08229.9 NM_008736.3_2 - 0.16 10.8 0.8 0.26 10.1 0.8 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 Xlink PF00193.15 NM_007529.2_2 - 6.8e-59 196.1 0.9 4.5e-29 100.6 0.0 3.7 3 1 1 4 4 4 2 Extracellular link domain Lectin_C PF00059.19 NM_007529.2_2 - 7e-22 78.1 4.4 3.5e-19 69.4 0.9 3.5 3 0 0 3 3 3 1 Lectin C-type domain V-set PF07686.15 NM_007529.2_2 - 6.1e-10 39.1 0.0 1.2e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain EGF PF00008.25 NM_007529.2_2 - 7.3e-07 29.2 7.4 3.1e-06 27.2 7.4 2.2 1 0 0 1 1 1 1 EGF-like domain Sushi PF00084.18 NM_007529.2_2 - 1.6e-05 25.3 0.0 7.7e-05 23.1 0.0 2.3 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) hEGF PF12661.5 NM_007529.2_2 - 5.8e-05 23.5 3.4 5.8e-05 23.5 3.4 3.9 4 0 0 4 4 4 1 Human growth factor-like EGF I-set PF07679.14 NM_007529.2_2 - 0.026 14.5 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.23 NM_007529.2_2 - 0.041 13.9 0.0 0.12 12.5 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin domain EGF_2 PF07974.11 NM_007529.2_2 - 0.046 14.0 11.0 0.025 14.8 7.5 2.5 2 0 0 2 2 2 0 EGF-like domain Izumo-Ig PF16706.3 NM_007529.2_2 - 0.048 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Sp38 PF07354.10 NM_007529.2_2 - 0.066 11.9 0.0 0.14 10.9 0.0 1.4 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Ig_2 PF13895.4 NM_007529.2_2 - 0.073 13.3 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain EGF_3 PF12947.5 NM_007529.2_2 - 0.13 12.3 1.0 0.36 10.9 1.0 1.7 1 0 0 1 1 1 0 EGF domain EGF_CA PF07645.13 NM_007529.2_2 - 0.32 11.1 8.7 0.31 11.1 5.0 3.0 3 1 0 3 3 3 0 Calcium-binding EGF domain Laminin_EGF PF00053.22 NM_007529.2_2 - 9.6 6.3 7.6 36 4.5 7.6 2.0 1 0 0 1 1 1 0 Laminin EGF domain PH PF00169.27 NM_027185.3_3 - 2.1e-18 66.6 0.2 4.4e-18 65.6 0.2 1.6 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 NM_027185.3_3 - 1.5e-05 25.0 0.0 4.2e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.8 NM_027185.3_3 - 0.00048 20.3 0.1 0.0018 18.5 0.1 2.1 1 1 0 1 1 1 1 Plant pleckstrin homology-like region PH_11 PF15413.4 NM_027185.3_3 - 0.0032 17.8 2.6 0.0032 17.8 2.6 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain EF-hand_6 PF13405.4 NM_027185.3_3 - 0.027 14.3 0.0 0.1 12.5 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.4 NM_027185.3_3 - 0.066 13.6 0.0 0.35 11.2 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain pair Harakiri PF15196.4 NM_027185.3_3 - 0.17 12.2 1.5 0.61 10.5 1.5 2.0 1 0 0 1 1 1 0 Activator of apoptosis harakiri OTU PF02338.17 NM_178691.4_2 - 6e-05 23.4 0.0 9.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Ubiquitin_2 PF14560.4 NM_178691.4_2 - 0.051 13.9 0.0 0.098 13.0 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain Ion_trans PF00520.29 NM_025734.2_2 - 3.4e-38 131.1 2.2 4.9e-38 130.6 2.2 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_025734.2_2 - 1.7e-23 82.7 0.0 2.8e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_025734.2_2 - 9.3e-12 44.6 2.8 9.3e-12 44.6 2.8 1.8 2 0 0 2 2 2 1 Ion channel 7tm_4 PF13853.4 NM_146287.1_1 - 5.5e-43 147.6 15.3 7e-43 147.2 15.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146287.1_1 - 3.8e-19 68.8 20.3 8.8e-19 67.6 20.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146287.1_1 - 1.3e-05 24.6 16.2 2.5e-05 23.7 16.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_146998.1_1 - 1.2e-52 179.3 17.8 1.4e-52 179.0 17.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146998.1_1 - 1.3e-16 60.6 15.7 2.4e-16 59.6 15.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146998.1_1 - 1.8e-07 30.6 7.5 1.8e-07 30.6 7.5 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 3Beta_HSD PF01073.17 NM_028725.3_1 - 2.5e-66 223.4 0.0 3.2e-66 223.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 NM_028725.3_1 - 1.1e-25 90.3 0.0 1.5e-25 89.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.15 NM_028725.3_1 - 1.2e-10 40.8 0.0 1.7e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.10 NM_028725.3_1 - 8.3e-09 34.8 0.0 1.3e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.13 NM_028725.3_1 - 1.2e-08 34.4 0.0 2.1e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.3 NM_028725.3_1 - 2.2e-07 30.4 0.0 1.4e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 NM_028725.3_1 - 2.7e-05 24.0 0.0 3.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.23 NM_028725.3_1 - 0.007 15.7 0.1 0.01 15.2 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Arm PF00514.21 NM_001272030.1_3 - 7e-39 130.6 7.8 2.8e-09 36.5 0.0 7.6 7 0 0 7 7 7 6 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 NM_001272030.1_3 - 2e-11 44.0 12.9 0.00055 20.2 0.4 6.6 6 0 0 6 6 6 3 HEAT-like repeat HEAT PF02985.20 NM_001272030.1_3 - 7.6e-08 31.8 10.9 0.025 14.7 0.1 5.3 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.4 NM_001272030.1_3 - 4.2e-07 30.1 15.9 8.8e-05 22.7 1.0 4.1 4 1 1 5 5 5 3 HEAT repeats Arm_2 PF04826.11 NM_001272030.1_3 - 0.0065 15.8 0.0 1.7 7.9 0.0 2.8 2 2 0 2 2 2 1 Armadillo-like Atx10homo_assoc PF09759.7 NM_001272030.1_3 - 0.0082 16.1 0.1 0.093 12.7 0.0 2.5 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain DUF4456 PF14644.4 NM_001272030.1_3 - 0.14 11.6 0.8 0.23 11.0 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) SPAN-X PF07458.10 NM_001177377.1_2 - 0.00034 20.8 6.1 0.0005 20.3 6.1 1.2 1 0 0 1 1 1 1 Sperm protein associated with nucleus, mapped to X chromosome Tautomerase PF01361.19 NM_001177377.1_2 - 0.0083 15.9 0.8 0.013 15.2 0.8 1.3 1 0 0 1 1 1 1 Tautomerase enzyme PA28_beta PF02252.16 NM_011189.1_1 - 7.8e-60 200.6 0.4 1e-59 200.2 0.4 1.2 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.16 NM_011189.1_1 - 5e-24 84.1 1.0 5e-24 84.1 1.0 1.8 2 0 0 2 2 2 1 Proteasome activator pa28 alpha subunit RNase_H2-Ydr279 PF09468.8 NM_011189.1_1 - 0.013 14.9 0.6 0.016 14.6 0.6 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) DUF1917 PF08939.8 NM_011189.1_1 - 0.057 13.1 0.4 0.08 12.7 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) Ribosomal_60s PF00428.17 NM_011189.1_1 - 0.87 10.0 6.1 1.9 9.0 5.6 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Methyltransf_16 PF10294.7 NM_028576.2_3 - 1.8e-18 66.8 0.0 2.5e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_11 PF08241.10 NM_028576.2_3 - 0.0095 16.4 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_028576.2_3 - 0.01 16.4 0.0 0.019 15.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.10 NM_028576.2_3 - 0.089 13.4 0.0 0.22 12.1 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain IL7 PF01415.14 NM_001313889.1_1 - 5.8e-36 123.4 8.0 1e-35 122.6 8.0 1.3 1 0 0 1 1 1 1 Interleukin 7/9 family zf-C3HC4_3 PF13920.4 NM_001302802.1_3 - 3.3e-09 36.3 4.7 3.3e-09 36.3 4.7 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RanBP PF00641.16 NM_001302802.1_3 - 4.5e-08 32.1 6.2 4.5e-08 32.1 6.2 2.2 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others SWIB PF02201.16 NM_001302802.1_3 - 1e-06 28.3 0.0 2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain 7tm_4 PF13853.4 NM_207665.1_1 - 4.4e-50 170.9 24.5 5.7e-50 170.5 24.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207665.1_1 - 7.4e-20 71.2 27.3 1.4e-19 70.3 27.3 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Lys PF00062.18 NM_001085393.2_1 - 5.3e-41 139.6 4.0 6.5e-41 139.3 4.0 1.1 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family MAM33 PF02330.14 NM_007573.2_2 - 4.8e-42 144.1 3.3 5.8e-42 143.8 3.3 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein Snf7 PF03357.19 NM_029814.1_2 - 7e-55 185.1 12.9 8.9e-55 184.8 12.9 1.1 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.10 NM_029814.1_2 - 0.00049 20.4 1.3 0.0036 17.6 0.5 2.4 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Prefoldin_2 PF01920.18 NM_029814.1_2 - 0.029 14.2 17.9 0.45 10.4 0.3 3.2 1 1 1 2 2 2 0 Prefoldin subunit Spc7 PF08317.9 NM_029814.1_2 - 0.15 10.8 11.5 0.25 10.1 11.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF848 PF05852.9 NM_029814.1_2 - 0.67 9.9 6.7 0.45 10.5 4.8 1.6 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) PDGF PF00341.15 NM_001308489.1_3 - 1.2e-23 83.0 9.0 4.6e-23 81.2 9.0 2.0 1 0 0 1 1 1 1 PDGF/VEGF domain CXCXC PF03128.12 NM_001308489.1_3 - 0.041 14.2 4.1 0.041 14.2 4.1 5.1 5 0 0 5 5 5 0 CXCXC repeat TMEM219 PF14940.4 NM_001081394.1_1 - 5.6e-82 274.7 0.0 7.5e-82 274.3 0.0 1.2 1 0 0 1 1 1 1 Transmembrane 219 PH_TFIIH PF08567.9 NM_008186.4_1 - 6.9e-25 87.1 0.0 1.3e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.15 NM_008186.4_1 - 1.8e-22 78.9 1.4 3.2e-16 58.9 0.0 3.0 2 0 0 2 2 2 2 BSD domain Crystall PF00030.17 NM_009967.2_2 - 3e-61 203.4 2.0 2.6e-30 104.3 0.1 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 NM_009967.2_2 - 0.00042 20.1 1.9 0.023 14.5 0.4 2.9 2 2 0 2 2 2 1 Peptidase inhibitor family I36 Crystall_3 PF08964.8 NM_009967.2_2 - 0.0037 17.3 0.2 1.4 9.0 0.0 3.1 3 0 0 3 3 3 1 Beta/Gamma crystallin BCLP PF12304.6 NM_133881.1_1 - 2.2e-46 157.6 14.9 7.6e-31 107.0 5.6 2.1 1 1 1 2 2 2 2 Beta-casein like protein CTD PF12815.5 NM_133881.1_2 - 0.038 14.4 3.7 0.073 13.5 3.7 1.5 1 0 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 V1R PF03402.12 NM_206869.2_1 - 7.4e-16 58.4 11.2 1.2e-15 57.8 11.2 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_206869.2_1 - 2.8e-13 49.5 14.4 3.7e-13 49.1 14.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_206869.2_1 - 6.2e-08 32.1 15.1 8.5e-08 31.6 15.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1700 PF08006.9 NM_206869.2_1 - 0.097 12.1 0.2 0.097 12.1 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1700) CcmE PF03100.13 NM_206869.2_1 - 0.14 12.0 0.3 16 5.4 0.1 2.4 2 0 0 2 2 2 0 CcmE DUF912 PF06024.10 NM_206869.2_1 - 3.4 7.9 4.9 32 4.7 0.1 2.9 2 1 1 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Fer4_6 PF12837.5 NM_206869.2_3 - 0.17 11.9 6.8 1.1 9.4 0.2 2.9 2 0 0 2 2 2 0 4Fe-4S binding domain ketoacyl-synt PF00109.24 NM_027695.3_1 - 1.3e-58 198.4 0.6 6e-58 196.3 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.20 NM_027695.3_1 - 1.5e-37 128.1 0.4 2.5e-37 127.4 0.4 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.21 NM_027695.3_1 - 0.0012 18.2 0.1 0.0041 16.4 0.1 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain RMI1_N PF08585.10 NM_001253755.1_1 - 9.2e-26 90.8 0.0 5.1e-23 81.8 0.0 2.4 1 1 0 1 1 1 1 RecQ mediated genome instability protein SMN PF06003.10 NM_001253755.1_1 - 1.7e-08 33.9 0.0 4.1e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.22 NM_001253755.1_1 - 2.4e-08 33.9 0.0 4.5e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Tudor domain UBA PF00627.29 NM_001253755.1_1 - 2.5e-06 27.1 0.2 4.4e-06 26.3 0.2 1.4 1 0 0 1 1 1 1 UBA/TS-N domain DUF1325 PF07039.9 NM_001253755.1_1 - 0.17 11.9 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 SGF29 tudor-like domain ISK_Channel PF02060.13 NM_021342.1_3 - 1.4e-07 31.1 0.0 2.7e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Slow voltage-gated potassium channel PMP22_Claudin PF00822.18 NM_001194922.1_2 - 1.4e-26 93.3 14.5 1.8e-25 89.6 14.5 2.3 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001194922.1_2 - 3.9e-08 33.1 14.9 3.9e-08 33.1 14.9 2.6 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction NIF PF03031.16 NM_025616.3_3 - 1.1e-34 119.3 0.0 1.6e-34 118.8 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase MEIOC PF15189.4 NM_001127576.2_1 - 2.2e-85 284.2 2.4 3.6e-85 283.5 2.4 1.3 1 0 0 1 1 1 1 Meiosis-specific coiled-coil domain-containing protein MEIOC CAMSAP_CC1 PF17095.3 NM_001127576.2_1 - 0.16 11.7 1.9 0.21 11.3 0.3 1.9 2 0 0 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin F-box-like PF12937.5 NM_015795.1_1 - 7.7e-10 38.4 4.0 1.9e-09 37.1 4.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_015795.1_1 - 9.2e-08 31.6 1.9 2.6e-07 30.2 1.9 1.8 1 0 0 1 1 1 1 F-box domain Tub PF01167.16 NM_021478.1_3 - 9.3e-80 267.3 0.0 1.2e-79 266.9 0.0 1.2 1 0 0 1 1 1 1 Tub family DUF4611 PF15387.4 NM_021478.1_3 - 0.68 10.1 21.0 0.047 13.8 10.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF3527 PF12043.6 NM_021478.1_3 - 0.84 9.0 2.7 0.65 9.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3527) GWT1 PF06423.10 NM_001011535.2_2 - 9.3 6.2 7.0 4.2 7.4 3.6 1.9 2 0 0 2 2 2 0 GWT1 7tm_4 PF13853.4 NM_001011535.2_3 - 8.1e-49 166.7 19.6 1.1e-48 166.2 19.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011535.2_3 - 1e-13 51.0 22.8 4e-13 49.1 22.8 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011535.2_3 - 4.8 6.4 29.6 0.34 10.1 21.8 2.3 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx MFS_1 PF07690.14 NM_028123.3_3 - 8.1e-39 133.4 26.9 1.1e-33 116.5 19.2 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_028123.3_3 - 1.2e-06 27.6 22.1 0.0002 20.2 4.7 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter Defensin_beta_2 PF13841.4 NM_001039122.1_3 - 1.5e-09 38.0 5.9 1.9e-09 37.7 5.9 1.1 1 0 0 1 1 1 1 Beta defensin VEFS-Box PF09733.7 NM_001163018.1_2 - 9.7e-54 180.7 3.1 1.9e-53 179.8 3.1 1.5 1 0 0 1 1 1 1 VEFS-Box of polycomb protein DUF2070 PF09843.7 NM_001163018.1_2 - 0.0073 14.5 0.1 0.0073 14.5 0.1 1.5 2 0 0 2 2 2 1 Predicted membrane protein (DUF2070) PDZ PF00595.22 NM_001029850.4_2 - 1.4e-66 220.7 5.3 5.3e-14 52.2 0.1 6.4 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) MAGI_u5 PF16666.3 NM_001029850.4_2 - 1.4e-44 151.4 9.1 1.4e-44 151.4 9.1 3.8 4 0 0 4 4 4 1 Unstructured region on MAGI MAGI_u1 PF16663.3 NM_001029850.4_2 - 1.7e-32 111.0 3.1 6.3e-32 109.2 3.1 2.1 1 0 0 1 1 1 1 Unstructured region on MAGI PDZ_2 PF13180.4 NM_001029850.4_2 - 4.3e-29 100.5 0.1 4.6e-05 23.5 0.0 6.6 7 0 0 7 7 7 5 PDZ domain WW PF00397.24 NM_001029850.4_2 - 4.1e-18 64.9 4.7 7.7e-10 38.4 0.4 2.7 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 NM_001029850.4_2 - 4.4e-10 39.4 0.0 1e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.4 NM_001029850.4_2 - 7.7e-07 28.9 7.4 0.19 11.6 0.0 5.4 6 0 0 6 6 6 3 Tricorn protease PDZ domain Serglycin PF04360.10 NM_001029850.4_2 - 0.094 12.5 0.4 0.2 11.5 0.4 1.5 1 0 0 1 1 1 0 Serglycin Arm_APC_u3 PF16629.3 NM_007462.3_3 - 2.6e-166 552.3 24.6 2.6e-166 552.3 24.6 2.9 3 0 0 3 3 3 1 Armadillo-associated region on APC APC_basic PF05956.9 NM_007462.3_3 - 1.6e-106 356.5 69.7 1.6e-106 356.5 69.7 9.1 7 3 2 9 9 2 1 APC basic domain EB1_binding PF05937.9 NM_007462.3_3 - 1.2e-84 283.1 25.5 1.2e-84 283.1 25.5 7.2 7 3 2 9 9 3 1 EB-1 Binding Domain APC_r PF05923.10 NM_007462.3_3 - 1.3e-66 219.0 56.3 2.3e-11 42.9 1.6 9.1 9 0 0 9 9 8 7 APC repeat APC_u5 PF16630.3 NM_007462.3_3 - 6.3e-51 171.4 7.8 6.3e-51 171.4 7.8 4.3 4 0 0 4 4 1 1 Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u14 PF16635.3 NM_007462.3_3 - 1.3e-38 131.2 11.6 1.3e-38 131.2 11.6 4.4 4 0 0 4 4 1 1 Unstructured region on APC between SAMP and APC_crr APC_u15 PF16636.3 NM_007462.3_3 - 2.2e-36 124.0 7.1 2.2e-36 124.0 7.1 5.2 3 0 0 3 3 2 1 Unstructured region on APC between APC_crr regions 5 and 6 APC_u9 PF16633.3 NM_007462.3_3 - 2.3e-30 105.4 8.4 2.3e-30 105.4 8.4 4.7 5 0 0 5 5 1 1 Unstructured region on APC between 1st two creatine-rich regions APC_N_CC PF16689.3 NM_007462.3_3 - 2.5e-28 97.8 7.3 2.5e-28 97.8 7.3 2.6 3 0 0 3 3 2 1 Coiled-coil N-terminus of APC, dimerisation domain SAMP PF05924.9 NM_007462.3_3 - 2.8e-28 96.2 16.2 3e-10 38.9 2.0 3.8 3 0 0 3 3 3 3 SAMP Motif Arm PF00514.21 NM_007462.3_3 - 4.4e-26 89.9 14.9 2.5e-07 30.4 0.5 6.6 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat APC_u13 PF16634.3 NM_007462.3_3 - 4.7e-26 90.3 1.5 4.7e-26 90.3 1.5 2.4 2 0 0 2 2 2 1 Unstructured region on APC between APC_crr and SAMP APC_15aa PF05972.9 NM_007462.3_3 - 1.6e-21 75.0 25.8 1.5e-05 24.8 0.1 5.4 5 0 0 5 5 5 4 APC 15 residue motif Suppressor_APC PF11414.6 NM_007462.3_3 - 8.1e-21 73.8 3.4 8.1e-21 73.8 3.4 3.1 3 0 0 3 3 3 1 Adenomatous polyposis coli tumour suppressor protein HALZ PF02183.16 NM_007462.3_3 - 0.36 10.9 8.5 0.071 13.2 2.0 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper JIP_LZII PF16471.3 NM_007462.3_3 - 1.2 9.2 10.1 0.094 12.8 3.3 2.7 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Baculo_PEP_C PF04513.10 NM_007462.3_3 - 3 7.8 7.1 12 5.7 0.6 3.4 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus RRM_1 PF00076.20 NM_028234.1_3 - 0.026 14.2 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4407 PF14362.4 NM_028234.1_3 - 5.1 6.2 8.9 11 5.2 8.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MFS_1 PF07690.14 NM_021053.4_1 - 2.2e-15 56.3 22.8 4.8e-15 55.2 20.7 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Iso_dh PF00180.18 NM_172901.2_1 - 1.1e-66 225.2 0.5 1.5e-66 224.8 0.5 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF4427 PF14468.4 NM_172901.2_1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4427) UCH PF00443.27 NM_001198573.1_2 - 1.7e-37 129.2 0.1 1.8e-32 112.7 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001198573.1_2 - 7.8e-20 71.6 0.0 1.4e-19 70.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase 7tm_1 PF00001.19 NM_001287119.1_2 - 1.4e-34 119.5 16.8 2e-34 118.9 16.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ni_hydr_CYTB PF01292.18 NM_001287119.1_2 - 0.072 12.6 5.8 1.7 8.1 3.5 2.9 2 1 1 3 3 3 0 Prokaryotic cytochrome b561 PDR_CDR PF06422.10 NM_001287119.1_2 - 6.3 6.6 6.7 36 4.2 3.4 2.6 1 1 1 2 2 2 0 CDR ABC transporter PTB PF08416.11 NM_007945.3_1 - 5.6e-54 181.7 0.5 9.4e-54 181.0 0.5 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SH3_1 PF00018.26 NM_007945.3_1 - 4.3e-11 42.1 0.0 8.4e-11 41.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_007945.3_1 - 3.1e-07 30.0 0.0 6.3e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PID PF00640.21 NM_007945.3_1 - 1.7e-06 28.0 0.2 4.1e-06 26.7 0.2 1.6 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH3_2 PF07653.15 NM_007945.3_1 - 3.5e-06 26.5 0.0 7.4e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 NM_007945.3_1 - 0.0035 17.5 0.1 0.032 14.4 0.0 2.4 2 0 0 2 2 2 1 Bacterial SH3 domain GBP PF02263.17 NM_178628.5_2 - 2.5e-100 334.9 0.2 3.3e-100 334.5 0.2 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 NM_178628.5_2 - 2.6e-05 23.7 0.1 3.7e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain PDEase_I PF00233.17 NM_001009979.1_3 - 4.7e-82 275.1 4.9 7.1e-82 274.6 4.9 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.10 NM_001009979.1_3 - 3.6e-32 109.9 0.1 6.8e-32 109.0 0.1 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal LSM PF01423.20 NM_001110101.2_2 - 4.4e-16 58.2 0.1 6e-16 57.8 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.4 NM_001110101.2_2 - 0.014 15.4 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain Muted PF14942.4 NM_139063.1_3 - 1e-50 171.7 6.3 1.4e-50 171.3 6.3 1.2 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein PAD PF03068.13 NM_011061.2_3 - 4.4e-173 575.6 0.0 5.7e-173 575.2 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) PAD_M PF08527.8 NM_011061.2_3 - 2.3e-60 202.7 0.0 4.4e-60 201.8 0.0 1.5 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) middle domain PAD_N PF08526.8 NM_011061.2_3 - 2.5e-35 121.1 0.0 4.1e-35 120.4 0.0 1.4 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain Glyco_transf_54 PF04666.11 NM_173771.4_3 - 5.5e-76 255.1 0.1 8.2e-76 254.5 0.1 1.2 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Sec34 PF04136.13 NM_173771.4_3 - 0.013 15.2 1.3 0.023 14.5 1.3 1.3 1 0 0 1 1 1 0 Sec34-like family fn3 PF00041.19 NM_172904.2_1 - 9.2e-17 61.0 1.0 1.6e-10 41.1 0.3 2.4 2 0 0 2 2 2 2 Fibronectin type III domain SPRY PF00622.26 NM_172904.2_1 - 2e-10 40.7 0.0 4.3e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 NM_172904.2_1 - 6.4e-07 28.8 0.0 1.3e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 SPRY-associated domain Pur_ac_phosph_N PF16656.3 NM_172904.2_1 - 0.01 16.2 1.4 0.02 15.3 0.7 1.7 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Apolipoprotein PF01442.16 NM_172904.2_1 - 0.057 13.2 2.2 0.096 12.5 2.2 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF3552 PF12072.6 NM_172904.2_1 - 0.33 10.2 6.3 0.53 9.5 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) C2 PF00168.28 NM_053271.2_3 - 5.4e-37 126.1 0.1 4.6e-19 68.5 0.0 3.0 3 0 0 3 3 3 2 C2 domain FYVE_2 PF02318.14 NM_053271.2_3 - 7e-10 39.0 18.6 1.5e-09 38.0 8.8 2.5 2 0 0 2 2 2 2 FYVE-type zinc finger PDZ PF00595.22 NM_053271.2_3 - 1.1e-05 25.5 0.0 2.3e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) BTB PF00651.29 NM_007528.3_3 - 1.2e-24 86.6 0.0 1.6e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 NM_007528.3_3 - 2.4e-23 81.3 46.3 1.5e-06 28.2 0.6 6.3 7 0 0 7 7 5 5 Zinc-finger double domain zf-C2H2 PF00096.24 NM_007528.3_3 - 1.8e-15 56.3 37.1 0.00016 21.8 0.4 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-met PF12874.5 NM_007528.3_3 - 6.9e-07 29.3 21.7 0.00093 19.4 0.2 5.5 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 NM_007528.3_3 - 4.2e-06 27.0 46.4 0.006 17.2 0.3 6.9 7 0 0 7 7 7 4 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_007528.3_3 - 0.0047 16.9 1.1 0.0047 16.9 1.1 4.5 1 1 5 6 6 6 3 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_007528.3_3 - 0.018 14.9 0.1 0.018 14.9 0.1 5.7 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_007528.3_3 - 0.061 13.5 7.4 18 5.7 0.3 4.8 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_007528.3_3 - 2.7 8.2 8.6 8.6 6.6 0.6 3.3 2 1 1 4 4 4 0 zinc-finger-containing domain zinc_ribbon_9 PF14369.4 NM_007528.3_3 - 4.4 7.5 7.7 41 4.4 0.1 4.3 4 0 0 4 4 4 0 zinc-ribbon ADK_lid PF05191.12 NM_007528.3_3 - 7 6.6 8.7 3.6 7.6 0.6 2.8 2 0 0 2 2 2 0 Adenylate kinase, active site lid HypA PF01155.17 NM_007528.3_3 - 7.3 6.5 9.5 37 4.2 5.8 3.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_9 PF16293.3 NM_007528.3_3 - 7.3 6.4 5.7 5.6 6.8 0.3 3.2 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_15 PF17032.3 NM_007528.3_3 - 7.6 7.2 10.6 32 5.2 0.6 3.5 1 1 1 3 3 3 0 zinc-ribbon family PWWP PF00855.15 NM_027557.1_3 - 2.2e-11 43.9 0.4 1.1e-10 41.7 0.0 2.2 2 0 0 2 2 2 1 PWWP domain TFB6 PF17110.3 NM_027557.1_3 - 2.6 7.6 5.4 6.7 6.3 5.4 1.7 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DIM1 PF02966.14 NM_001042408.1_1 - 6.6e-19 67.9 0.0 9.6e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 Mitosis protein DIM1 Acetyltransf_1 PF00583.23 NM_001042408.1_3 - 1.1e-14 54.6 0.0 1.7e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 NM_001042408.1_3 - 2.8e-10 40.1 0.0 4.7e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 NM_001042408.1_3 - 6.3e-08 32.8 0.0 1.2e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 NM_001042408.1_3 - 2.9e-07 30.2 0.0 5.5e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.5 NM_001042408.1_3 - 0.0052 16.7 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.4 NM_001042408.1_3 - 0.01 15.7 0.1 0.02 14.8 0.1 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.3 NM_001042408.1_3 - 0.026 13.8 0.2 0.044 13.1 0.2 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_3 PF13302.5 NM_001042408.1_3 - 0.037 14.6 0.0 0.073 13.6 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain RCC1 PF00415.16 NM_001081282.2_2 - 3.8e-37 126.5 11.2 7.2e-12 45.6 1.7 4.6 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.29 NM_001081282.2_2 - 5e-31 107.1 11.4 6.1e-16 58.5 0.2 2.7 3 0 0 3 3 3 2 BTB/POZ domain Ank_5 PF13857.4 NM_001081282.2_2 - 3.6e-09 36.6 0.0 0.00065 19.9 0.0 4.0 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_001081282.2_2 - 1.3e-08 35.1 0.0 1.1e-05 25.7 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_001081282.2_2 - 2.8e-08 34.1 0.0 8.5e-08 32.5 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) RCC1_2 PF13540.4 NM_001081282.2_2 - 3.9e-07 29.6 11.2 0.012 15.2 0.1 5.6 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat Ank PF00023.28 NM_001081282.2_2 - 7.3e-05 22.9 0.0 0.05 13.9 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.4 NM_001081282.2_2 - 0.00025 21.1 0.0 0.54 10.9 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat DUF3342 PF11822.6 NM_001081282.2_2 - 0.047 13.8 1.0 0.21 11.7 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) PARG_cat PF05028.12 NM_011960.2_3 - 1.2e-132 442.2 0.0 1.8e-132 441.6 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) SNF PF00209.16 NM_009209.3_1 - 1.6e-238 792.5 35.3 1.6e-238 792.5 35.3 1.4 2 0 0 2 2 2 1 Sodium:neurotransmitter symporter family PH PF00169.27 NM_001033391.2_2 - 8.4e-06 26.1 0.2 4.2e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_9 PF15410.4 NM_001033391.2_2 - 0.017 15.4 0.2 0.1 12.9 0.1 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain TMEM171 PF15471.4 NM_001033391.2_2 - 0.34 9.7 4.4 0.49 9.2 4.4 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 Humanin PF15040.4 NM_001033391.2_2 - 0.5 9.8 6.6 4.5 6.8 0.2 2.5 2 0 0 2 2 2 0 Humanin family OATP PF03137.18 NM_001252530.1_2 - 1.3e-192 640.9 9.4 1.6e-192 640.5 9.4 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 NM_001252530.1_2 - 1.5e-15 56.8 17.9 1.5e-15 56.8 17.9 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF3392 PF11872.6 NM_001252530.1_2 - 0.12 12.5 2.0 0.46 10.6 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3392) Kazal_2 PF07648.13 NM_001252530.1_2 - 0.56 10.3 8.3 1.2 9.2 8.3 1.6 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain fn3 PF00041.19 NM_010233.2_1 - 9.9e-260 839.7 84.0 5e-19 68.3 0.2 17.3 17 0 0 17 17 17 17 Fibronectin type III domain fn1 PF00039.16 NM_010233.2_1 - 1.5e-145 473.0 162.2 5.4e-15 55.2 6.4 12.9 13 0 0 13 13 13 12 Fibronectin type I domain fn2 PF00040.17 NM_010233.2_1 - 9.8e-35 118.4 21.9 3.2e-17 62.4 6.6 3.6 2 0 0 2 2 2 2 Fibronectin type II domain DUF2369 PF10179.7 NM_010233.2_1 - 1.9e-33 114.6 8.3 0.0026 18.1 0.0 14.8 15 1 1 16 16 16 8 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.3 NM_010233.2_1 - 5.6e-33 113.3 45.4 0.0036 17.7 0.0 19.0 15 6 0 15 15 15 9 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 NM_010233.2_1 - 1.3e-17 63.8 0.0 1.5 9.1 0.0 13.4 15 0 0 15 15 15 2 Interferon-alpha/beta receptor, fibronectin type III DUF4959 PF16323.3 NM_010233.2_1 - 2.8e-10 40.3 6.0 0.3 11.3 0.0 8.2 8 1 0 8 8 8 2 Domain of unknown function (DUF4959) DUF4912 PF16258.3 NM_010233.2_1 - 3.1e-07 30.5 0.0 0.88 9.7 0.0 6.7 8 0 0 8 8 8 2 Domain of unknown function (DUF4912) DUF1410 PF07198.9 NM_010233.2_1 - 4.1e-06 27.1 6.5 12 6.4 0.0 7.8 8 0 0 8 8 8 1 Protein of unknown function (DUF1410) fn3_2 PF16893.3 NM_010233.2_1 - 0.04 13.9 6.1 23 5.1 0.1 6.1 6 0 0 6 6 6 0 Fibronectin type III domain MHC_II_beta PF00969.17 NM_010382.2_1 - 3.1e-37 126.4 0.6 5.2e-37 125.7 0.6 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 NM_010382.2_1 - 8.1e-25 87.0 1.0 1.7e-24 85.9 0.2 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 NM_010382.2_1 - 1.5e-05 25.4 0.1 3.5e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 NM_010382.2_1 - 0.00014 21.8 0.1 0.00028 20.9 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain DUF1992 PF09350.8 NM_138664.2_1 - 2.6e-21 75.4 0.0 2e-20 72.6 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1992) DnaJ PF00226.29 NM_138664.2_1 - 1.5e-11 44.1 0.1 3.8e-11 42.8 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain Pkinase PF00069.23 NM_013767.6_2 - 2.3e-26 92.6 0.0 3.2e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_013767.6_2 - 3.3e-16 59.2 0.0 4.6e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_013767.6_2 - 0.00084 19.2 0.2 0.0036 17.1 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family FXa_inhibition PF14670.4 NM_001205204.1_1 - 1.8e-09 37.6 33.8 4.8e-08 33.0 3.5 4.2 3 0 0 3 3 3 3 Coagulation Factor Xa inhibitory site Tme5_EGF_like PF09064.8 NM_001205204.1_1 - 0.011 15.5 0.9 0.011 15.5 0.9 3.5 3 0 0 3 3 3 0 Thrombomodulin like fifth domain, EGF-like MACPF PF01823.17 NM_001205204.1_1 - 0.015 15.3 0.1 0.043 13.8 0.0 1.7 2 0 0 2 2 2 0 MAC/Perforin domain Peptidase_C65 PF10275.7 NM_134150.2_2 - 3.6e-86 288.5 2.2 4.9e-86 288.0 2.2 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.17 NM_134150.2_2 - 1.7e-06 28.4 0.2 0.00016 22.1 0.2 2.4 1 1 0 1 1 1 1 OTU-like cysteine protease Lipoprotein_7 PF01540.14 NM_134150.2_2 - 0.046 12.9 0.5 0.087 12.0 0.5 1.3 1 1 0 1 1 1 0 Adhesin lipoprotein Ank_4 PF13637.4 NM_001039553.2_3 - 2.6e-30 104.3 3.2 3.8e-12 46.3 0.1 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_001039553.2_3 - 8.1e-26 90.3 0.8 1.1e-13 51.4 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_001039553.2_3 - 5.3e-25 87.0 0.3 6.1e-13 48.6 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001039553.2_3 - 1.6e-18 64.7 0.8 1.7e-05 24.7 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.28 NM_001039553.2_3 - 2.8e-18 65.4 2.6 0.0002 21.5 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat TPR_12 PF13424.4 NM_001168477.1_1 - 0.99 9.6 2.7 1.8 8.8 2.7 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001168477.1_1 - 4.7 7.4 5.2 50 4.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TMEM72 PF16054.3 NM_001135991.1_1 - 3.6 7.1 6.1 2.4 7.7 4.6 1.4 1 1 0 1 1 1 0 Transmembrane protein family 72 Keratin_B2_2 PF13885.4 NM_001135991.1_2 - 9.7e-25 86.1 346.5 4.7e-09 35.9 69.2 6.5 1 1 5 6 6 6 5 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_001135991.1_2 - 0.016 15.1 198.4 0.037 13.9 57.4 4.3 1 1 1 2 2 2 0 Keratin, high sulfur B2 protein COPIIcoated_ERV PF07970.10 NM_026168.4_2 - 3.4e-47 161.0 0.3 5.1e-47 160.4 0.3 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.4 NM_026168.4_2 - 3e-23 81.8 0.3 5.4e-23 81.0 0.3 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) WD40 PF00400.30 NM_178398.4_2 - 0.001 19.7 0.0 14 6.6 0.0 4.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_178398.4_2 - 0.11 12.7 0.0 2.1 8.6 0.0 2.7 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Uteroglobin PF01099.15 NM_001270542.1_3 - 6.9e-20 70.9 0.9 8.8e-20 70.6 0.9 1.1 1 0 0 1 1 1 1 Uteroglobin family DBB PF14545.4 NM_001310749.1_2 - 3.1e-19 69.2 0.0 6.1e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 Dof, BCAP, and BANK (DBB) motif, Ank_2 PF12796.5 NM_001310749.1_2 - 0.03 14.8 0.1 0.074 13.5 0.1 1.6 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Hom_end PF05204.12 NM_001310749.1_3 - 0.11 12.5 0.2 0.22 11.6 0.2 1.4 1 0 0 1 1 1 0 Homing endonuclease FGF PF00167.16 NM_010204.1_3 - 1.6e-40 138.0 0.0 2.9e-40 137.1 0.0 1.4 1 0 0 1 1 1 1 Fibroblast growth factor MTHFR PF02219.15 NM_001161798.1_3 - 2.2e-117 391.3 0.0 2.8e-117 391.0 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase RSRP PF17069.3 NM_019973.2_1 - 4.5e-05 23.1 84.5 4.5e-05 23.1 84.5 4.6 3 2 1 4 4 4 1 Arginine/Serine-Rich protein 1 LSR PF05624.12 NM_017405.2_3 - 5.1e-24 83.9 37.0 1.1e-23 82.8 37.0 1.6 1 0 0 1 1 1 1 Lipolysis stimulated receptor (LSR) V-set PF07686.15 NM_017405.2_3 - 0.00016 21.6 0.1 0.002 18.1 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain Troponin PF00992.18 NM_011619.3_2 - 1.6e-35 122.2 51.1 2.3e-31 108.8 36.9 3.1 2 1 1 3 3 3 2 Troponin LRR_8 PF13855.4 NM_001290741.1_3 - 1.2e-14 53.6 15.1 1.3e-10 40.7 6.1 3.2 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 NM_001290741.1_3 - 3.4e-11 43.0 12.0 6.8e-07 29.3 1.5 3.1 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) Exo_endo_phos PF03372.21 NM_001290741.1_3 - 6.7e-09 35.9 0.0 1e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_6 PF13516.4 NM_001290741.1_3 - 0.02 14.8 14.4 0.87 9.7 0.3 4.7 4 0 0 4 4 4 0 Leucine Rich repeat GTP_EFTU PF00009.25 NM_001159672.1_1 - 1.6e-61 207.1 0.0 4.3e-61 205.7 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.22 NM_001159672.1_1 - 2.1e-18 66.0 0.0 4.9e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.4 NM_001159672.1_1 - 3.8e-08 33.2 0.0 9.2e-08 31.9 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.23 NM_001159672.1_1 - 3.4e-07 30.4 0.0 1.2e-06 28.7 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.16 NM_001159672.1_1 - 0.0003 20.4 0.2 0.015 15.0 0.0 3.3 4 0 0 4 4 4 1 Elongation factor G, domain IV MMR_HSR1 PF01926.21 NM_001159672.1_1 - 0.022 14.7 0.0 0.054 13.5 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase zf-met PF12874.5 NM_007562.2_1 - 1.4e-08 34.7 24.5 0.0016 18.6 0.1 5.1 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 NM_007562.2_1 - 2e-05 24.9 41.5 0.035 14.8 3.1 8.0 8 0 0 8 8 8 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_007562.2_1 - 2e-05 24.6 20.8 0.039 14.2 1.1 4.1 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.24 NM_007562.2_1 - 4.2e-05 23.6 42.6 0.047 14.0 2.0 7.7 7 1 0 7 7 7 4 Zinc finger, C2H2 type DUF1947 PF09183.8 NM_007562.2_1 - 0.16 12.2 0.2 0.34 11.1 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) zf-C2H2_aberr PF17017.3 NM_007562.2_1 - 0.38 10.7 9.0 2.3 8.2 0.3 3.4 3 0 0 3 3 3 0 Aberrant zinc-finger zf-DNA_Pol PF08996.8 NM_007562.2_1 - 2.6 7.6 16.7 1.4 8.5 0.3 3.4 3 0 0 3 3 3 0 DNA Polymerase alpha zinc finger Myotub-related PF06602.12 NM_172958.3_1 - 3.5e-55 187.2 6.1 1.8e-52 178.3 6.1 2.2 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain 3-PAP PF12578.6 NM_172958.3_1 - 4.7e-39 133.0 0.5 8.6e-39 132.2 0.5 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein Atrophin-1 PF03154.13 NM_172958.3_2 - 0.24 9.5 11.1 0.34 9.0 11.1 1.1 1 0 0 1 1 1 0 Atrophin-1 family Pou PF00157.15 NM_001163555.1_3 - 9e-38 128.0 0.2 1.7e-37 127.1 0.2 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 NM_001163555.1_3 - 1.8e-16 59.5 3.7 3.9e-16 58.5 3.7 1.6 1 0 0 1 1 1 1 Homeobox domain HSF_DNA-bind PF00447.15 NM_027661.2_1 - 6e-21 74.7 0.5 1.1e-20 73.8 0.5 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding 7tm_1 PF00001.19 NM_001287123.1_1 - 2.2e-34 118.8 16.8 3.2e-34 118.2 16.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ni_hydr_CYTB PF01292.18 NM_001287123.1_1 - 0.43 10.0 6.8 16 4.9 6.9 2.7 2 1 1 3 3 3 0 Prokaryotic cytochrome b561 Folate_carrier PF01770.16 NM_031196.3_1 - 1.3e-163 544.4 17.4 1.6e-163 544.1 17.4 1.0 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.14 NM_031196.3_1 - 2.4e-11 43.0 22.5 2.7e-11 42.9 21.3 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily WAPL PF07814.11 NM_001004436.4_3 - 3.1e-116 388.0 7.4 4.7e-116 387.4 7.4 1.3 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin 7tm_4 PF13853.4 NM_001011811.1_1 - 1.7e-49 168.9 20.7 2.1e-49 168.6 20.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011811.1_1 - 1.4e-22 80.1 21.8 3.2e-22 78.9 21.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) WD40 PF00400.30 NM_146016.2_3 - 1.4e-62 206.0 87.5 5.9e-05 23.6 0.0 26.9 31 0 0 31 31 31 14 WD domain, G-beta repeat HELP PF03451.12 NM_146016.2_3 - 2.3e-56 187.4 2.6 1.2e-19 69.8 0.1 3.4 3 0 0 3 3 3 3 HELP motif ANAPC4_WD40 PF12894.5 NM_146016.2_3 - 8.1e-35 118.9 9.6 3.1e-07 30.5 0.0 12.3 8 4 4 12 12 12 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 NM_146016.2_3 - 1.5e-08 33.9 5.1 0.024 13.5 0.0 7.1 4 3 3 8 8 8 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.3 NM_146016.2_3 - 2.1e-06 27.1 1.3 0.72 9.0 0.0 6.4 7 0 0 7 7 7 2 WD40-like domain Nucleoporin_N PF08801.9 NM_146016.2_3 - 2.3e-05 23.2 0.0 0.036 12.7 0.0 4.0 4 0 0 4 4 4 1 Nup133 N terminal like Cytochrom_D1 PF02239.14 NM_146016.2_3 - 3.5e-05 22.4 8.7 0.04 12.3 0.0 5.4 5 1 1 6 6 6 3 Cytochrome D1 heme domain Frtz PF11768.6 NM_146016.2_3 - 5.8e-05 21.5 0.0 0.021 13.0 0.0 3.5 3 1 1 4 4 4 1 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.10 NM_146016.2_3 - 0.00043 20.0 0.4 73 3.3 0.0 6.2 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Nup160 PF11715.6 NM_146016.2_3 - 0.0039 15.7 0.2 9.7 4.5 0.0 4.1 4 0 0 4 4 4 1 Nucleoporin Nup120/160 ANF_receptor PF01094.26 NM_175481.5_3 - 6.5e-60 203.0 0.0 9.7e-60 202.4 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 NM_175481.5_3 - 2.8e-48 163.4 0.1 4.4e-48 162.8 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_175481.5_3 - 3e-44 149.7 0.0 9.6e-44 148.1 0.0 1.8 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_175481.5_3 - 1.1e-19 70.7 0.0 1.8e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Phospholip_A2_1 PF00068.17 NM_001291009.2_2 - 2e-22 79.6 9.2 2e-22 79.6 9.2 1.7 2 0 0 2 2 2 1 Phospholipase A2 Parvo_coat_N PF08398.8 NM_001291009.2_2 - 0.17 11.9 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus coat protein VP1 tRNA_int_end_N2 PF12928.5 NM_029557.1_2 - 6.3e-19 67.8 0.4 1.1e-18 67.0 0.4 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.12 NM_029557.1_2 - 0.0014 18.1 0.0 0.0029 17.1 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain HCO3_cotransp PF00955.19 NM_001136260.1_1 - 1e-229 763.5 8.1 1.4e-229 763.1 8.1 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 NM_001136260.1_1 - 1.8e-98 329.5 0.1 1.8e-98 329.5 0.1 2.0 3 0 0 3 3 3 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 NM_001136260.1_1 - 0.00079 19.2 0.0 0.01 15.6 0.0 2.4 3 0 0 3 3 3 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Fmp27_WPPW PF10359.7 NM_001136260.1_1 - 0.019 13.7 0.1 0.053 12.2 0.1 1.6 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Xan_ur_permease PF00860.18 NM_001136260.1_1 - 4.5 5.7 16.7 0.35 9.4 1.4 2.9 3 0 0 3 3 3 0 Permease family FAM176 PF14851.4 NM_001136260.1_1 - 5.4 6.6 6.3 15 5.1 1.6 2.3 2 0 0 2 2 2 0 FAM176 family SpoIIM PF01944.15 NM_001033250.4_2 - 0.06 13.2 0.0 0.086 12.7 0.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein M LEM PF03020.13 NM_001033250.4_3 - 2.7e-18 65.1 1.1 3.2e-18 64.8 0.2 1.6 2 0 0 2 2 2 1 LEM domain Nore1-SARAH PF16517.3 NM_175445.4_1 - 8.2e-15 54.4 5.6 1.9e-14 53.2 5.6 1.7 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain RA PF00788.21 NM_175445.4_1 - 8.1e-13 48.7 0.0 1.5e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Glyco_transf_29 PF00777.16 NM_001276425.1_3 - 6.3e-34 117.4 0.0 1e-33 116.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) DUF1741 PF08427.8 NM_198296.2_1 - 9.6e-81 270.6 6.9 1.7e-80 269.8 6.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) Herpes_UL37_1 PF03970.11 NM_198296.2_1 - 0.079 12.0 0.6 1.7 7.6 0.1 2.5 2 0 0 2 2 2 0 Herpesvirus UL37 tegument protein Occludin_ELL PF07303.11 NM_198296.2_1 - 0.099 13.2 0.8 0.65 10.6 0.0 2.6 3 0 0 3 3 3 0 Occludin homology domain Defensin_beta PF00711.17 NM_183026.2_3 - 8.7e-10 38.3 13.0 1.1e-09 38.0 13.0 1.1 1 0 0 1 1 1 1 Beta defensin Complex1_LYR PF05347.13 NM_025987.3_1 - 1e-09 38.2 0.0 1.7e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 NM_025987.3_1 - 0.00016 22.2 0.1 0.00025 21.6 0.1 1.3 1 0 0 1 1 1 1 Complex1_LYR-like DUF4252 PF14060.4 NM_025987.3_1 - 0.17 11.7 0.2 0.26 11.0 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) zf-H2C2_2 PF13465.4 NM_001160251.1_2 - 1.9e-15 56.4 26.0 3.1e-06 27.3 0.2 5.4 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001160251.1_2 - 1.4e-08 34.7 32.4 0.015 16.0 3.6 5.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_001160251.1_2 - 2.7e-08 33.7 39.8 0.0054 17.0 0.8 5.3 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_001160251.1_2 - 1.3 8.9 20.1 0.27 11.1 1.3 4.7 4 0 0 4 4 4 0 C2H2-type zinc finger GAGA PF09237.9 NM_001160251.1_2 - 2.3 8.0 7.2 0.35 10.6 1.3 2.5 2 1 0 2 2 2 0 GAGA factor DZR PF12773.5 NM_001160251.1_2 - 4.6 7.2 7.2 15 5.6 2.0 2.5 2 0 0 2 2 2 0 Double zinc ribbon 7tm_4 PF13853.4 NM_001200027.1_1 - 2.9e-109 365.0 27.3 4.4e-109 364.4 27.3 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001200027.1_1 - 5.7e-20 71.5 23.7 1.1e-19 70.6 23.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001200027.1_1 - 1.5e-10 40.8 20.8 3.2e-10 39.7 20.8 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx FGF-BP1 PF06473.10 NM_028263.1_3 - 2.4e-54 184.5 0.0 3.1e-54 184.1 0.0 1.1 1 0 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) Yip1 PF04893.15 NM_207633.2_2 - 2.9e-17 62.8 11.1 5.9e-17 61.8 11.1 1.5 1 0 0 1 1 1 1 Yip1 domain RPE65 PF03055.13 NM_021486.3_2 - 3.3e-110 369.0 0.1 3.9e-110 368.7 0.1 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Linker_histone PF00538.17 NM_138311.3_2 - 6.7e-22 77.5 0.0 1.3e-21 76.6 0.0 1.5 1 0 0 1 1 1 1 linker histone H1 and H5 family Peptidase_M18 PF02127.13 NM_016878.4_2 - 3.4e-196 652.1 0.1 1.4e-195 650.0 0.0 1.8 2 0 0 2 2 2 1 Aminopeptidase I zinc metalloprotease (M18) EOS1 PF12326.6 NM_016878.4_2 - 0.21 11.4 0.1 0.27 11.0 0.1 1.3 1 0 0 1 1 1 0 N-glycosylation protein FAM176 PF14851.4 NM_016878.4_2 - 5.9 6.4 5.8 11 5.6 5.8 1.4 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.17 NM_016878.4_2 - 8.8 5.9 14.0 13 5.3 14.0 1.2 1 0 0 1 1 1 0 Connexin SDF PF00375.16 NM_001077514.3_3 - 1.9e-130 435.3 30.3 2.6e-130 434.8 30.3 1.2 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Rootletin PF15035.4 NM_001145958.1_1 - 6.7e-43 146.8 20.8 6.7e-43 146.8 20.8 16.3 4 3 12 16 16 16 2 Ciliary rootlet component, centrosome cohesion 7tm_1 PF00001.19 NM_008965.2_1 - 6.5e-34 117.3 7.2 8.5e-34 116.9 7.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) NdhL PF10716.7 NM_008965.2_1 - 0.013 15.4 0.8 0.054 13.3 0.0 2.5 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit Abhydrolase_9_N PF15420.4 NM_008965.2_1 - 2.9 7.7 6.4 2.9 7.7 3.4 2.1 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Torus PF16131.3 NM_011746.2_3 - 4.4e-11 43.3 7.6 0.00055 20.5 0.1 3.4 3 0 0 3 3 3 3 Torus domain MKRN1_C PF15815.3 NM_011746.2_3 - 1.1e-08 35.2 0.0 2.4e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase makorin-1, C-terminal zf-CCCH PF00642.22 NM_011746.2_3 - 4.7e-08 32.6 24.3 0.0002 21.1 1.4 3.8 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4 PF00097.23 NM_011746.2_3 - 1.1e-06 28.3 5.0 1.1e-06 28.3 5.0 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_011746.2_3 - 1.4e-05 25.1 6.1 1.4e-05 25.1 6.1 3.6 4 0 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.4 NM_011746.2_3 - 2.6e-05 24.0 5.2 2.6e-05 24.0 5.2 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.5 NM_011746.2_3 - 0.00037 20.6 4.3 0.00037 20.6 4.3 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain Podoplanin PF05808.9 NM_001290822.1_1 - 1.2e-58 197.7 2.6 1.6e-58 197.2 2.6 1.2 1 0 0 1 1 1 1 Podoplanin 7tm_4 PF13853.4 NM_146452.2_1 - 1.6e-46 159.1 14.2 2e-46 158.9 14.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146452.2_1 - 1.6e-23 83.2 16.6 2.2e-23 82.7 15.9 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146452.2_1 - 3.8e-05 23.1 12.2 5.2e-05 22.6 12.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_146452.2_1 - 0.014 14.6 8.7 0.037 13.2 8.5 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx PAP2 PF01569.19 NM_145521.3_3 - 1.1e-13 51.0 4.7 2.3e-13 50.0 4.7 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.4 NM_145521.3_3 - 9.8e-05 22.0 5.2 0.00021 20.9 5.2 1.6 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 NM_145521.3_3 - 0.042 14.2 1.4 0.11 12.9 1.4 1.7 1 0 0 1 1 1 0 PAP2 superfamily C-terminal Cadherin PF00028.15 NM_138661.1_1 - 1e-68 227.7 0.0 6.1e-17 61.7 0.1 6.4 5 1 1 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 NM_138661.1_1 - 3.5e-63 211.7 4.7 7.9e-63 210.6 4.7 1.6 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 NM_138661.1_1 - 1.3e-32 111.3 0.4 9.9e-30 102.1 0.1 3.8 3 0 0 3 3 3 1 Cadherin-like Cadherin_3 PF16184.3 NM_138661.1_1 - 1.5e-06 28.0 4.8 0.49 10.3 0.1 4.9 5 0 0 5 5 5 3 Cadherin-like Cadherin_C_2 PF16492.3 NM_138661.1_1 - 7.6e-06 26.5 0.1 2.9e-05 24.6 0.1 2.1 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal WD40 PF00400.30 NM_008143.3_3 - 6.6e-49 162.7 25.3 9.8e-09 35.6 0.2 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_008143.3_3 - 4.3e-10 39.6 0.7 0.0045 17.1 0.0 4.6 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_008143.3_3 - 8.3e-05 22.4 0.2 0.0096 15.7 0.0 2.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 NM_008143.3_3 - 0.00022 20.2 0.1 0.99 8.2 0.0 3.9 2 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 NM_008143.3_3 - 0.004 15.7 7.8 0.18 10.3 0.1 4.3 3 1 2 5 5 5 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.14 NM_008143.3_3 - 0.0099 14.3 0.0 0.035 12.5 0.1 1.9 1 1 1 2 2 2 1 Cytochrome D1 heme domain WD40_like PF17005.3 NM_008143.3_3 - 0.015 14.5 0.0 4.1 6.5 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain PD40 PF07676.10 NM_008143.3_3 - 0.12 12.2 1.0 21 5.1 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat 7tm_4 PF13853.4 NM_146289.1_1 - 9.8e-46 156.6 15.4 1.3e-45 156.2 15.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146289.1_1 - 4.2e-20 72.0 18.9 8.6e-20 71.0 18.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 NM_146289.1_1 - 9.9e-06 24.9 16.4 1.5e-05 24.3 16.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.7 NM_146289.1_1 - 1.5e-05 24.4 15.9 2.9e-05 23.4 15.9 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V-SNARE PF05008.13 NM_001034059.1_1 - 0.34 11.2 8.1 0.41 10.9 2.7 2.6 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus OmpH PF03938.12 NM_001034059.1_1 - 1.1 9.1 8.6 2.8 7.8 8.6 1.7 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) zf-B_box PF00643.22 NM_030219.2_1 - 1.4e-07 31.4 14.3 3.1e-07 30.3 3.3 6.1 7 0 0 7 7 7 3 B-box zinc finger fn3 PF00041.19 NM_030219.2_1 - 1.5e-06 28.3 0.0 2.8e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_030219.2_1 - 0.0034 17.8 0.0 0.0074 16.7 0.0 1.7 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain CHDCT2 PF08074.9 NM_030219.2_1 - 0.0035 17.4 1.6 0.0075 16.3 1.6 1.5 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF386 PF04074.10 NM_030219.2_1 - 0.063 13.1 0.3 0.13 12.0 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF386) Defensin_beta PF00711.17 NM_139219.2_2 - 8.9e-11 41.5 10.6 8.9e-11 41.5 10.6 1.6 2 0 0 2 2 2 1 Beta defensin Myotoxins PF00819.15 NM_139219.2_2 - 3.6 7.8 16.2 1.2 9.3 3.8 2.9 1 1 1 2 2 2 0 Myotoxin, crotamine EF-hand_8 PF13833.4 NM_009393.2_2 - 1e-27 95.5 15.0 7.2e-15 54.4 0.4 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.4 NM_009393.2_2 - 6.4e-26 90.5 10.8 5.1e-15 55.6 7.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_009393.2_2 - 1.1e-24 84.0 25.5 5.4e-08 31.7 1.0 4.7 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.4 NM_009393.2_2 - 1.1e-19 68.5 16.5 1.9e-07 30.3 0.7 4.9 3 1 2 5 5 5 4 EF-hand domain EF-hand_5 PF13202.4 NM_009393.2_2 - 1.6e-14 52.6 19.9 3e-06 26.4 0.6 4.8 4 1 1 5 5 5 3 EF hand EF-hand_9 PF14658.4 NM_009393.2_2 - 2.3e-12 46.9 1.5 6.2e-06 26.3 0.5 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 NM_009393.2_2 - 3.3e-05 23.6 7.6 0.028 14.2 0.1 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 NM_009393.2_2 - 0.00014 22.0 1.8 0.0029 17.8 1.8 2.2 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.11 NM_009393.2_2 - 0.0025 17.6 0.1 2.5 7.9 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB UPF0154 PF03672.11 NM_009393.2_2 - 0.0095 15.8 0.0 1.6 8.7 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) DUF1707 PF08044.9 NM_009393.2_2 - 0.011 15.7 0.6 1.5 8.8 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1707) EF-hand_10 PF14788.4 NM_009393.2_2 - 0.018 14.8 1.8 0.1 12.4 0.9 2.5 1 1 1 2 2 2 0 EF hand DUF1456 PF07308.11 NM_009393.2_2 - 0.11 12.8 2.2 3.3 8.0 0.3 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF1456) TPR_1 PF00515.26 NM_001163516.3_2 - 1.8e-22 78.0 0.0 4.9e-05 22.8 0.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001163516.3_2 - 5.2e-19 66.6 2.3 0.00063 19.5 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001163516.3_2 - 9.4e-16 56.5 0.4 0.0061 16.6 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001163516.3_2 - 2.9e-12 45.9 0.6 0.0043 16.6 0.0 4.6 3 2 2 5 5 5 3 TPR repeat TPR_17 PF13431.4 NM_001163516.3_2 - 3.6e-11 42.5 3.9 0.19 12.0 0.4 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001163516.3_2 - 1e-10 41.4 3.9 0.0085 16.7 0.5 5.4 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001163516.3_2 - 3.1e-10 40.3 4.0 0.0033 17.8 1.6 4.1 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001163516.3_2 - 8e-10 38.6 1.1 0.0035 17.4 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001163516.3_2 - 4.2e-08 33.2 2.8 2.2 8.5 0.0 4.2 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.4 NM_001163516.3_2 - 4.4e-07 30.0 1.8 0.0013 18.8 0.4 3.7 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001163516.3_2 - 1.1e-06 29.1 12.2 1.3e-05 25.6 0.2 4.1 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001163516.3_2 - 1e-05 25.0 0.8 2.4 8.2 0.1 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001163516.3_2 - 4.7e-05 23.6 0.5 34 5.3 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001163516.3_2 - 8.7e-05 22.5 2.1 0.23 11.6 1.6 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF4248 PF14053.4 NM_001163516.3_2 - 0.037 14.0 0.1 0.089 12.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) SHNi-TPR PF10516.7 NM_001163516.3_2 - 0.19 11.1 5.2 25 4.3 0.8 3.5 3 0 0 3 3 3 0 SHNi-TPR Sulfotransfer_2 PF03567.12 NM_021439.2_3 - 8.5e-67 225.6 6.7 1.2e-66 225.1 6.7 1.2 1 0 0 1 1 1 1 Sulfotransferase family IIGP PF05049.11 NM_001145164.1_2 - 4.1e-175 582.1 0.2 5.1e-175 581.8 0.2 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.21 NM_001145164.1_2 - 2e-06 27.7 0.0 3.7e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 NM_001145164.1_2 - 5.3e-05 23.2 0.1 0.032 14.1 0.1 2.5 1 1 1 2 2 2 2 Dynamin family ABC_tran PF00005.25 NM_001145164.1_2 - 0.0011 19.4 0.0 0.0022 18.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.16 NM_001145164.1_2 - 0.0015 17.8 0.0 0.0025 17.1 0.0 1.2 1 0 0 1 1 1 1 FtsK/SpoIIIE family DUF258 PF03193.14 NM_001145164.1_2 - 0.0016 18.3 0.1 0.0042 16.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 FeoB_N PF02421.16 NM_001145164.1_2 - 0.0056 16.1 0.0 0.0091 15.4 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF87 PF01935.15 NM_001145164.1_2 - 0.0078 16.1 0.3 0.05 13.5 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function DUF87 ArgK PF03308.14 NM_001145164.1_2 - 0.011 14.5 0.1 0.016 14.0 0.1 1.1 1 0 0 1 1 1 0 ArgK protein AAA_22 PF13401.4 NM_001145164.1_2 - 0.014 15.5 0.0 0.044 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.12 NM_001145164.1_2 - 0.016 14.3 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain T2SSE PF00437.18 NM_001145164.1_2 - 0.024 13.5 0.0 0.041 12.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.4 NM_001145164.1_2 - 0.029 13.9 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.11 NM_001145164.1_2 - 0.039 14.1 0.0 0.073 13.2 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.4 NM_001145164.1_2 - 0.062 12.9 0.0 0.097 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.24 NM_001145164.1_2 - 0.098 12.2 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.15 NM_001145164.1_2 - 0.1 12.4 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Septin PF00735.16 NM_001145164.1_2 - 0.12 11.4 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Septin AAA_16 PF13191.4 NM_001145164.1_2 - 0.14 12.4 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.4 NM_001145164.1_2 - 1.1 9.6 4.8 1.9 8.8 3.8 2.1 1 1 0 1 1 1 0 AAA domain Filament PF00038.19 NM_008469.2_2 - 3e-118 394.8 32.0 3.4e-118 394.6 32.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein Atg14 PF10186.7 NM_008469.2_2 - 0.00018 20.6 0.8 0.00018 20.6 0.8 2.4 2 1 1 3 3 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.10 NM_008469.2_2 - 0.0042 17.0 2.8 0.0042 17.0 2.8 3.9 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Bacillus_HBL PF05791.9 NM_008469.2_2 - 0.006 16.2 8.4 0.011 15.4 1.8 2.5 1 1 0 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) DUF4618 PF15397.4 NM_008469.2_2 - 0.009 15.3 8.2 0.009 15.3 8.2 3.0 3 1 1 4 4 4 1 Domain of unknown function (DUF4618) Reo_sigmaC PF04582.10 NM_008469.2_2 - 0.032 13.5 4.7 0.066 12.5 1.2 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein SPATA1_C PF15743.3 NM_008469.2_2 - 0.095 12.6 0.2 0.095 12.6 0.2 3.7 1 1 1 3 3 3 0 Spermatogenesis-associated C-terminus DUF4686 PF15742.3 NM_008469.2_2 - 0.17 10.8 26.9 0.11 11.4 5.3 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4686) Baculo_PEP_C PF04513.10 NM_008469.2_2 - 0.18 11.7 16.2 3.6 7.5 0.7 3.7 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.4 NM_008469.2_2 - 0.29 10.3 15.7 0.31 10.2 6.2 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Jnk-SapK_ap_N PF09744.7 NM_008469.2_2 - 0.31 11.1 25.6 0.96 9.5 6.0 3.4 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 Spc29 PF17082.3 NM_008469.2_2 - 0.33 10.6 9.8 0.85 9.3 0.1 3.3 1 1 1 3 3 3 0 Spindle Pole Component 29 FlxA PF14282.4 NM_008469.2_2 - 0.42 10.5 13.7 4.7 7.1 6.9 2.6 2 0 0 2 2 2 0 FlxA-like protein DUF1664 PF07889.10 NM_008469.2_2 - 0.61 10.0 16.7 0.56 10.1 1.8 4.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) POX PF07526.9 NM_008469.2_2 - 0.74 10.3 6.9 1.8 9.1 1.8 3.1 2 2 1 3 3 3 0 Associated with HOX SlyX PF04102.10 NM_008469.2_2 - 0.77 10.3 25.5 1.8 9.1 0.6 5.1 4 1 1 5 5 5 0 SlyX Fib_alpha PF08702.8 NM_008469.2_2 - 0.99 9.5 18.5 3.5 7.7 5.5 3.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Keratin_2_head PF16208.3 NM_008469.2_2 - 1.4 8.9 56.2 0.073 13.1 48.0 2.2 2 0 0 2 2 2 0 Keratin type II head RasGAP_C PF03836.13 NM_008469.2_2 - 3.8 7.5 17.4 1.2 9.2 0.1 3.7 3 1 1 4 4 4 0 RasGAP C-terminus DUF641 PF04859.10 NM_008469.2_2 - 4.3 7.5 17.2 6.5 7.0 2.0 3.5 2 2 1 3 3 3 0 Plant protein of unknown function (DUF641) Prefoldin_2 PF01920.18 NM_008469.2_2 - 4.8 7.1 22.0 8.5 6.3 0.8 4.4 3 1 0 3 3 3 0 Prefoldin subunit DUF4709 PF15821.3 NM_008469.2_2 - 5.6 7.1 14.0 13 6.0 3.7 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4709) DUF4446 PF14584.4 NM_008469.2_2 - 7.9 6.3 12.7 4.5 7.1 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) Phage_GP20 PF06810.9 NM_008469.2_2 - 8.8 6.0 18.8 3.5 7.3 1.4 3.7 2 2 1 4 4 4 0 Phage minor structural protein GP20 CENP-F_leu_zip PF10473.7 NM_008469.2_2 - 8.8 6.2 28.8 6.8 6.6 2.3 4.2 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.13 NM_008469.2_2 - 9.2 6.0 24.3 4.7 6.9 0.6 4.7 5 0 0 5 5 5 0 Septum formation initiator Pkinase PF00069.23 NM_001112705.2_3 - 5.7e-62 209.3 0.0 9.9e-62 208.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001112705.2_3 - 1.9e-35 122.3 0.0 4.1e-35 121.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Vir_act_alpha_C PF10400.7 NM_001112705.2_3 - 0.081 13.5 6.3 0.52 10.9 0.4 2.8 2 0 0 2 2 2 0 Virulence activator alpha C-term YcaO PF02624.14 NM_001112705.2_3 - 0.12 11.5 0.3 3.1 6.9 0.1 2.2 2 0 0 2 2 2 0 YcaO cyclodehydratase, ATP-ad Mg2+-binding Trefoil PF00088.16 NM_009363.3_2 - 2.7e-26 91.0 19.8 7.9e-14 51.1 5.5 2.5 2 0 0 2 2 2 2 Trefoil (P-type) domain TEX29 PF15839.3 NM_009363.3_2 - 0.2 12.2 7.3 0.64 10.5 0.9 2.3 2 0 0 2 2 2 0 Testis-expressed sequence 29 protein Keratin_2_head PF16208.3 NM_183126.2_1 - 0.058 13.4 3.2 0.086 12.9 3.2 1.2 1 0 0 1 1 1 0 Keratin type II head KRTAP PF11759.6 NM_183126.2_1 - 0.15 12.5 7.2 0.3 11.5 7.2 1.4 1 0 0 1 1 1 0 Keratin-associated matrix FAM219A PF15260.4 NM_027993.3_1 - 1.4e-52 177.2 3.0 1.4e-52 177.2 3.0 1.8 2 0 0 2 2 2 1 Protein family FAM219A PMP22_Claudin PF00822.18 NM_001101560.1_1 - 7.4e-26 90.9 9.1 8.8e-26 90.6 9.1 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001101560.1_1 - 7.8e-06 25.6 9.0 0.00021 21.0 8.6 2.2 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction zf-C4 PF00105.16 NM_145434.4_3 - 6.4e-31 106.5 15.0 1.3e-30 105.5 15.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_145434.4_3 - 9.6e-28 97.0 1.0 1.7e-27 96.2 1.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor tRNA-synt_1c PF00749.19 NM_133794.2_1 - 2.6e-116 387.8 0.0 3.9e-116 387.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.13 NM_133794.2_1 - 1.5e-51 174.5 0.0 2.7e-51 173.6 0.0 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.16 NM_133794.2_1 - 4.5e-45 153.5 0.0 8.2e-45 152.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.13 NM_133794.2_1 - 7.3e-28 97.2 1.1 1.3e-27 96.4 1.1 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 p450 PF00067.20 NM_001105160.1_3 - 1.2e-125 419.8 0.3 1.4e-125 419.6 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1869 PF08956.8 NM_001105160.1_3 - 0.1 12.4 0.0 3 7.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1869) NACHT PF05729.10 NM_001003910.2_3 - 7.1e-09 35.7 0.1 1e-07 31.9 0.0 2.7 2 1 0 2 2 2 1 NACHT domain TPR_12 PF13424.4 NM_001003910.2_3 - 6.7e-07 29.4 0.5 0.26 11.5 0.1 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat AAA_16 PF13191.4 NM_001003910.2_3 - 0.00028 21.2 0.0 0.00084 19.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 NM_001003910.2_3 - 0.00069 19.8 0.0 0.0019 18.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF4062 PF13271.4 NM_001003910.2_3 - 0.0021 18.3 0.0 0.012 15.9 0.0 2.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) TPR_1 PF00515.26 NM_001003910.2_3 - 0.0051 16.4 2.3 1.5 8.6 0.5 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Rad17 PF03215.13 NM_001003910.2_3 - 0.0062 15.4 1.9 0.17 10.6 0.1 2.3 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein ATPase_2 PF01637.16 NM_001003910.2_3 - 0.012 15.4 0.7 0.23 11.2 0.0 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea TPR_8 PF13181.4 NM_001003910.2_3 - 0.044 13.9 5.9 2.5 8.4 1.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat AAA PF00004.27 NM_001003910.2_3 - 0.061 13.6 0.0 0.75 10.1 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.4 NM_001003910.2_3 - 0.07 12.7 0.3 0.22 11.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain TPR_2 PF07719.15 NM_001003910.2_3 - 0.099 12.7 2.5 61 4.0 0.3 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA_14 PF13173.4 NM_001003910.2_3 - 0.1 12.5 0.0 0.31 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.11 NM_001003910.2_3 - 0.11 11.5 0.0 0.22 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) zf-RING_2 PF13639.4 NM_001290501.1_2 - 6.2e-12 45.5 9.7 6.2e-12 45.5 9.7 3.6 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.3 NM_001290501.1_2 - 9.5e-11 41.1 2.2 4.1e-10 39.1 2.2 2.3 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 NM_001290501.1_2 - 2e-07 30.6 8.7 2e-07 30.6 8.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001290501.1_2 - 1.3e-06 28.0 8.1 7e-06 25.7 8.1 2.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 NM_001290501.1_2 - 3.5e-05 23.9 8.0 0.0002 21.5 8.0 2.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.4 NM_001290501.1_2 - 0.00068 19.3 6.7 0.0049 16.6 6.7 2.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001290501.1_2 - 0.00073 19.3 7.4 0.0033 17.2 7.4 2.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 NM_001290501.1_2 - 0.012 15.5 1.7 0.079 12.9 1.7 2.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Syja_N PF02383.16 NM_030692.4_3 - 2.9e-92 309.2 0.6 3.7e-92 308.8 0.6 1.1 1 0 0 1 1 1 1 SacI homology domain FKBP_C PF00254.26 NM_010222.2_1 - 1e-28 99.4 0.0 1.5e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.4 NM_010222.2_1 - 4.5e-09 36.5 0.9 8.2e-09 35.7 0.9 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_010222.2_1 - 6.8e-08 31.4 1.4 0.0023 17.2 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.4 NM_010222.2_1 - 1.1e-07 30.9 0.7 0.00083 18.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_010222.2_1 - 1.2e-07 30.9 2.2 0.014 15.2 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain WBP-1 PF11669.6 NM_001105561.1_2 - 7.6e-09 36.0 6.0 1.4e-08 35.2 6.0 1.4 1 0 0 1 1 1 1 WW domain-binding protein 1 LAT PF15234.4 NM_001105561.1_3 - 0.11 12.1 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells DUF4499 PF14934.4 NM_026679.2_1 - 9.5e-35 118.7 4.0 1.7e-34 117.9 4.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) CUE PF02845.14 NM_001164295.1_1 - 0.0003 20.3 0.0 0.00054 19.5 0.0 1.4 1 0 0 1 1 1 1 CUE domain TGF_beta PF00019.18 NM_001163282.2_1 - 3.1e-28 98.6 0.0 4.9e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 NM_001163282.2_1 - 0.24 11.0 0.0 0.63 9.6 0.0 1.5 1 1 0 1 1 1 0 TGF-beta propeptide TRAM_LAG1_CLN8 PF03798.14 NM_001163282.2_2 - 8.9e-33 113.6 29.2 1.5e-32 112.8 29.2 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.9 NM_001163282.2_2 - 0.1 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 TRAM1-like protein ABM PF03992.14 NM_178617.4_3 - 6.7e-11 42.0 0.1 1.1e-10 41.4 0.1 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase EF-hand_1 PF00036.30 NM_178617.4_3 - 1.9e-07 30.0 3.2 0.0002 20.5 0.8 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 NM_178617.4_3 - 1.3e-06 28.0 1.2 0.0025 17.4 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.4 NM_178617.4_3 - 1.6e-06 28.3 0.6 0.022 15.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_178617.4_3 - 1.6e-05 24.4 2.9 0.086 12.7 0.3 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 NM_178617.4_3 - 7e-05 22.0 2.0 0.0002 20.6 0.6 2.2 1 1 1 2 2 2 1 EF hand RraB PF06877.9 NM_178617.4_3 - 0.12 12.9 0.9 0.23 12.0 0.9 1.4 1 0 0 1 1 1 0 Regulator of ribonuclease activity B MRP-L28 PF09812.7 NM_178617.4_3 - 1.9 8.5 7.7 0.068 13.2 1.4 1.7 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 UPAR_LY6 PF00021.19 NM_001164036.1_1 - 2.5e-14 53.6 12.9 2.5e-14 53.6 12.9 1.9 2 0 0 2 2 2 1 u-PAR/Ly-6 domain Toxin_1 PF00087.19 NM_001164036.1_1 - 5.4e-06 26.4 12.5 5.4e-06 26.4 12.5 1.9 2 0 0 2 2 2 1 Snake toxin RRM_1 PF00076.20 NM_176838.2_1 - 6.9e-09 35.3 0.0 0.0027 17.4 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.22 NM_176838.2_1 - 0.09 13.2 0.0 0.15 12.5 0.0 1.2 1 0 0 1 1 1 0 Exonuclease CAP_N PF01213.17 NM_176838.2_1 - 8.1 5.7 9.4 18 4.5 9.4 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal zf-H2C2_2 PF13465.4 NM_145078.2_1 - 1e-26 92.0 101.9 4.9e-07 29.8 4.8 10.4 11 0 0 11 11 11 7 Zinc-finger double domain KRAB PF01352.25 NM_145078.2_1 - 3.1e-19 68.2 2.9 6e-19 67.3 2.9 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2 PF00096.24 NM_145078.2_1 - 2.5e-12 46.4 108.3 9.2e-05 22.6 6.0 12.4 12 0 0 12 12 12 6 Zinc finger, C2H2 type zf-C2H2_11 PF16622.3 NM_145078.2_1 - 0.0012 18.4 9.7 0.0047 16.5 2.2 9.7 11 0 0 11 11 11 3 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 NM_145078.2_1 - 0.0059 16.4 3.3 0.0059 16.4 3.3 7.0 8 0 0 8 8 8 2 C2H2-type zinc finger Pkinase_Tyr PF07714.15 NM_001199293.1_1 - 3.5e-27 95.2 0.0 7.4e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001199293.1_1 - 2.1e-18 66.5 0.0 4.3e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.5 NM_001199293.1_1 - 1.3e-08 35.1 0.1 4.8e-08 33.4 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001199293.1_1 - 6e-07 29.8 0.0 5.2e-06 26.8 0.0 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001199293.1_1 - 8.8e-05 22.5 0.0 0.014 15.8 0.0 3.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.4 NM_001199293.1_1 - 0.00069 19.8 0.1 0.0027 17.9 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 NM_001199293.1_1 - 0.0021 18.3 0.2 5.9 7.4 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ead_Ea22 PF13935.4 NM_001199293.1_1 - 0.004 17.7 3.5 0.004 17.7 3.5 2.5 2 0 0 2 2 2 1 Ead/Ea22-like protein BLOC1_2 PF10046.7 NM_001199293.1_1 - 3.7 7.8 9.2 0.54 10.5 0.5 3.7 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 7tm_4 PF13853.4 NM_130868.1_1 - 4.2e-46 157.8 15.3 5.1e-46 157.5 15.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_130868.1_1 - 2.8e-23 82.4 17.6 5.7e-23 81.4 17.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Herpes_U15 PF05613.9 NM_130868.1_1 - 0.62 10.7 4.4 0.22 12.1 1.5 1.8 2 0 0 2 2 2 0 Human herpesvirus U15 protein BIR PF00653.19 NM_010870.2_1 - 1e-56 189.4 8.2 4.1e-21 75.3 0.4 3.8 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain NACHT PF05729.10 NM_010870.2_1 - 6.1e-35 120.5 0.2 2.5e-34 118.5 0.1 2.2 2 0 0 2 2 2 1 NACHT domain LRR_4 PF12799.5 NM_010870.2_1 - 0.0088 16.3 0.4 0.0088 16.3 0.4 6.9 8 1 0 9 9 9 1 Leucine Rich repeats (2 copies) AAA_30 PF13604.4 NM_010870.2_1 - 0.055 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.15 NM_010870.2_1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_pol_N PF01194.15 NM_010870.2_1 - 1.7 8.9 10.0 6 7.1 0.1 3.7 4 0 0 4 4 4 0 RNA polymerases N / 8 kDa subunit SR-25 PF10500.7 NM_010870.2_2 - 0.12 11.9 21.0 0.23 10.9 21.0 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein C1q PF00386.19 NM_028331.5_3 - 2e-36 124.9 0.1 2.6e-36 124.5 0.1 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 NM_028331.5_3 - 1.4e-07 31.0 15.8 1.4e-07 31.0 15.8 2.2 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) LPG_synthase_TM PF03706.11 NM_001166620.1_3 - 0.0074 15.7 0.1 0.011 15.2 0.1 1.1 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region CCER1 PF15482.4 NM_001166620.1_3 - 0.025 14.3 0.6 0.025 14.3 0.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing glutamate-rich protein family 1 TMEM100 PF16311.3 NM_001166620.1_3 - 1.9 8.0 4.4 0.49 9.9 0.3 2.0 2 0 0 2 2 2 0 Transmembrane protein 100 HIN PF02760.13 NM_001204910.1_3 - 1.3e-72 242.8 0.2 1.3e-72 242.8 0.2 1.6 2 0 0 2 2 2 1 HIN-200/IF120x domain PYRIN PF02758.14 NM_001204910.1_3 - 9e-09 35.3 0.4 2e-08 34.2 0.2 1.7 2 0 0 2 2 2 1 PAAD/DAPIN/Pyrin domain Ribosomal_S19 PF00203.19 NM_001310726.1_2 - 2.7e-40 136.0 0.4 3.8e-40 135.5 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 MAP65_ASE1 PF03999.10 NM_001310726.1_2 - 0.029 12.9 0.9 0.037 12.6 0.9 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Prok_Ub PF14454.4 NM_001310726.1_2 - 0.031 13.8 0.1 0.073 12.6 0.1 1.5 1 0 0 1 1 1 0 Prokaryotic Ubiquitin LCAT PF02450.13 NM_001310726.1_2 - 0.21 10.6 0.1 0.27 10.2 0.1 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF2722 PF10846.6 NM_008748.3_1 - 0.068 12.0 3.6 0.097 11.5 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.6 NM_008748.3_1 - 0.94 8.9 11.4 1.6 8.2 11.4 1.2 1 0 0 1 1 1 0 Spt20 family DSPc PF00782.18 NM_008748.3_2 - 4.2e-43 146.2 0.0 7.5e-43 145.4 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.18 NM_008748.3_2 - 1.9e-08 34.6 0.0 3.7e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Y_phosphatase PF00102.25 NM_008748.3_2 - 0.0064 16.0 0.1 0.015 14.8 0.0 1.5 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Reprolysin PF01421.17 NM_020330.5_2 - 1.1e-47 162.4 0.2 1.1e-47 162.4 0.2 2.0 2 0 0 2 2 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 NM_020330.5_2 - 3.2e-28 98.3 10.2 3.2e-28 98.3 10.2 3.7 3 2 1 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.21 NM_020330.5_2 - 4.9e-19 68.8 24.0 4.9e-19 68.8 24.0 4.4 4 0 0 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.17 NM_020330.5_2 - 2.5e-18 66.5 0.1 4.2e-18 65.8 0.1 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_020330.5_2 - 3.4e-17 63.1 0.2 6.7e-17 62.2 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 NM_020330.5_2 - 7.5e-13 48.9 0.0 1.4e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_020330.5_2 - 9.7e-08 32.0 0.1 2.2e-07 30.8 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_020330.5_2 - 1.1e-06 28.4 0.9 3.3e-06 26.8 1.0 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.9 NM_020330.5_2 - 0.034 14.0 0.2 0.068 13.0 0.2 1.4 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M57 PF12388.6 NM_020330.5_2 - 0.042 13.3 0.1 0.073 12.5 0.1 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M10 PF00413.22 NM_020330.5_2 - 0.11 12.2 0.1 0.22 11.2 0.1 1.4 1 0 0 1 1 1 0 Matrixin Tme5_EGF_like PF09064.8 NM_029464.2_2 - 0.065 13.0 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like zf-H2C2_2 PF13465.4 NM_009564.2_1 - 2.4e-39 131.9 88.1 2.2e-07 30.9 2.6 11.4 11 1 0 11 11 11 8 Zinc-finger double domain zf-H2C2_5 PF13909.4 NM_009564.2_1 - 1.2e-36 123.9 73.0 7.2e-08 31.9 3.9 10.3 10 0 0 10 10 10 9 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 NM_009564.2_1 - 5.2e-32 108.4 91.5 0.0006 20.0 0.8 11.1 11 0 0 11 11 11 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_009564.2_1 - 3.7e-19 67.6 90.4 0.01 16.4 1.6 11.5 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_009564.2_1 - 6.1e-09 35.5 1.1 6.1e-09 35.5 1.1 10.4 12 0 0 12 12 12 2 C2H2-type zinc finger zf-met PF12874.5 NM_009564.2_1 - 1.1e-05 25.5 8.1 0.00056 20.1 0.4 9.5 11 1 0 11 11 11 5 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 NM_009564.2_1 - 0.012 15.2 0.1 0.012 15.2 0.1 7.7 9 0 0 9 9 9 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 NM_009564.2_1 - 0.38 11.0 57.0 0.87 9.8 0.1 10.2 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding GAGA PF09237.9 NM_009564.2_1 - 0.91 9.2 19.4 7.5 6.3 0.0 6.3 2 1 4 6 6 6 0 GAGA factor zf-C2H2_2 PF12756.5 NM_009564.2_1 - 1.1 9.5 57.1 0.4 10.9 1.7 7.9 2 1 5 7 7 7 0 C2H2 type zinc-finger (2 copies) p450 PF00067.20 NM_007819.4_3 - 1.4e-128 429.4 0.1 1.7e-128 429.1 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 EF-hand_6 PF13405.4 NM_026770.1_3 - 3.6e-07 29.5 0.1 0.00034 20.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.4 NM_026770.1_3 - 4.2e-06 27.0 0.0 8.8e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_026770.1_3 - 2.7e-05 23.2 0.0 0.11 11.9 0.0 2.4 2 0 0 2 2 2 2 EF hand Peptidase_A22B PF04258.11 NM_001159553.1_2 - 6.6e-13 48.7 0.0 1e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 Signal peptide peptidase DUF4345 PF14248.4 NM_001159553.1_2 - 0.1 12.4 0.5 0.21 11.4 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4345) zf-H2C2_2 PF13465.4 NM_020596.2_2 - 2.1e-12 46.7 7.9 3e-07 30.5 0.8 4.6 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_020596.2_2 - 7.7e-11 41.7 13.9 0.004 17.7 2.4 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_020596.2_2 - 4.6e-10 39.2 22.2 0.0009 19.4 3.8 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_020596.2_2 - 0.00014 21.6 5.1 0.36 10.7 0.4 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.3 NM_020596.2_2 - 0.013 15.7 6.3 0.024 14.8 3.2 2.3 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-met PF12874.5 NM_020596.2_2 - 0.037 14.3 11.1 0.24 11.7 1.4 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.4 NM_020596.2_2 - 0.076 12.8 8.7 3.8 7.4 0.5 3.6 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Zf_RING PF16744.3 NM_020596.2_2 - 0.11 12.5 1.5 1.9 8.5 0.1 2.2 1 1 1 2 2 2 0 KIAA1045 RING finger zf-RRN7 PF11781.6 NM_020596.2_2 - 0.39 10.3 3.0 7.1 6.3 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-BED PF02892.13 NM_020596.2_2 - 1.4 8.9 6.5 4.8 7.2 6.2 2.1 1 1 0 1 1 1 0 BED zinc finger WD40 PF00400.30 NM_027963.2_1 - 1e-30 105.2 16.5 0.0062 17.2 0.2 11.3 11 1 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_027963.2_1 - 1.6e-06 28.2 0.6 0.36 11.0 0.0 5.7 3 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_027963.2_1 - 0.00056 19.2 0.1 3.1 6.9 0.0 4.1 3 1 2 5 5 5 2 WD40-like domain Nucleoporin_N PF08801.9 NM_027963.2_1 - 0.058 12.0 1.1 41 2.6 0.0 4.7 3 2 1 5 5 5 0 Nup133 N terminal like Sulfotransfer_1 PF00685.25 NM_026935.4_3 - 3e-93 312.0 0.5 3.9e-93 311.7 0.5 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_026935.4_3 - 5.8e-06 26.7 0.1 0.00087 19.6 0.1 2.2 2 0 0 2 2 2 2 Sulfotransferase family Syntaxin PF00804.23 NM_026935.4_3 - 0.036 13.6 0.1 0.067 12.7 0.1 1.3 1 0 0 1 1 1 0 Syntaxin Rhomboid PF01694.20 NM_144816.1_3 - 2e-35 121.8 8.5 3.4e-35 121.1 8.5 1.4 1 0 0 1 1 1 1 Rhomboid family HPP PF04982.11 NM_144816.1_3 - 0.078 13.1 0.1 0.078 13.1 0.1 2.5 1 1 2 3 3 3 0 HPP family zf-C3HC4_3 PF13920.4 NM_001302801.1_2 - 3.3e-09 36.3 4.7 3.3e-09 36.3 4.7 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RanBP PF00641.16 NM_001302801.1_2 - 4.6e-08 32.1 6.2 4.6e-08 32.1 6.2 2.3 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others SWIB PF02201.16 NM_001302801.1_2 - 1.1e-06 28.3 0.0 2.1e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain HNF-1_N PF04814.11 NM_177338.5_2 - 9.4e-63 212.2 4.3 1.9e-62 211.2 4.3 1.5 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homeobox PF00046.27 NM_177338.5_2 - 3.2e-10 39.5 1.9 5e-10 38.9 0.6 2.1 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 NM_177338.5_2 - 0.00028 20.6 0.6 0.0056 16.4 0.1 2.6 2 0 0 2 2 2 1 Homeobox KN domain HTH_37 PF13744.4 NM_177338.5_2 - 0.0012 18.5 0.3 0.003 17.3 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.20 NM_177338.5_2 - 0.0087 16.0 0.1 0.018 15.0 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.5 NM_177338.5_2 - 0.011 15.6 0.1 0.1 12.6 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain DUF494 PF04361.11 NM_177338.5_2 - 0.045 13.5 0.0 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF494) HTH_24 PF13412.4 NM_177338.5_2 - 0.057 12.8 0.0 0.15 11.5 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_31 PF13560.4 NM_177338.5_2 - 0.11 12.8 1.6 0.21 11.8 0.1 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_23 PF13384.4 NM_177338.5_2 - 0.14 11.8 0.2 0.76 9.5 0.2 2.2 1 0 0 1 1 1 0 Homeodomain-like domain Pex14_N PF04695.11 NM_177338.5_2 - 0.41 11.2 2.6 0.65 10.6 0.9 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PUF PF00806.17 NM_001160219.1_1 - 9.7e-71 229.5 10.4 2.1e-09 36.4 0.0 9.0 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.9 NM_001160219.1_1 - 0.035 14.3 1.2 8.7 6.6 0.1 3.6 1 1 2 3 3 3 0 CPL (NUC119) domain PC4 PF02229.14 NM_001160219.1_1 - 0.14 11.7 0.3 0.31 10.6 0.3 1.5 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) BIR PF00653.19 NM_010871.2_2 - 1.2e-08 35.4 4.9 2.9e-06 27.7 0.0 3.0 3 0 0 3 3 3 2 Inhibitor of Apoptosis domain BIR PF00653.19 NM_010871.2_3 - 8.8e-57 189.6 9.1 1.9e-21 76.4 0.5 3.7 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain NACHT PF05729.10 NM_010871.2_3 - 2.3e-34 118.6 0.2 7.6e-34 116.9 0.1 2.0 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.4 NM_010871.2_3 - 0.012 15.2 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_pol_N PF01194.15 NM_010871.2_3 - 0.37 11.0 6.5 7.7 6.8 0.1 3.4 3 0 0 3 3 3 0 RNA polymerases N / 8 kDa subunit LRR_4 PF12799.5 NM_010871.2_3 - 6 7.3 19.5 0.095 13.0 0.3 6.0 5 1 2 7 7 7 0 Leucine Rich repeats (2 copies) Myc_target_1 PF15179.4 NM_001141924.1_1 - 0.015 15.1 0.8 0.038 13.8 0.8 1.6 1 0 0 1 1 1 0 Myc target protein 1 EphA2_TM PF14575.4 NM_001141924.1_1 - 1.3 9.8 4.1 0.48 11.1 0.5 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TRAM1 PF08390.9 NM_001308481.1_2 - 0.072 12.6 0.1 0.072 12.6 0.1 2.3 2 0 0 2 2 2 0 TRAM1-like protein PWWP PF00855.15 NM_001308481.1_3 - 2e-21 76.1 1.8 2e-21 76.1 1.8 2.3 2 0 0 2 2 2 1 PWWP domain BHD_1 PF10403.7 NM_145563.2_1 - 0.00012 21.8 0.1 38 4.1 0.0 5.8 5 0 0 5 5 5 1 Rad4 beta-hairpin domain 1 zf-H2C2_2 PF13465.4 NM_145563.2_1 - 0.00075 19.7 7.1 0.0024 18.1 0.4 3.3 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.24 NM_145563.2_1 - 5.8 7.4 8.8 19 5.8 8.8 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 NM_145563.2_1 - 6.9 6.6 9.5 34 4.4 9.5 2.1 1 1 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_145563.2_3 - 2.6e-129 416.3 136.2 1.8e-09 37.4 0.3 18.1 17 1 1 18 18 18 17 Zinc-finger double domain zf-C2H2 PF00096.24 NM_145563.2_3 - 2.2e-68 223.0 138.4 2.3e-05 24.5 3.1 15.8 15 0 0 15 15 15 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_145563.2_3 - 3.3e-46 151.8 148.9 0.00086 19.8 0.2 16.4 17 0 0 17 17 15 15 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_145563.2_3 - 7.3e-25 86.3 110.3 0.0041 16.9 0.8 16.3 15 1 0 15 15 15 13 C2H2-type zinc finger KRAB PF01352.25 NM_145563.2_3 - 3.1e-21 74.6 0.2 4.7e-21 74.1 0.2 1.3 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_145563.2_3 - 8.2e-12 45.0 109.0 0.046 13.9 0.6 15.1 15 0 0 15 15 15 11 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_145563.2_3 - 2.2e-11 43.1 73.0 0.15 11.7 0.4 14.4 15 0 0 15 15 14 9 zinc-finger C2H2-type C1_1 PF00130.20 NM_145563.2_3 - 4.2e-10 39.2 67.8 0.018 14.8 5.9 11.5 1 1 13 14 14 14 10 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.8 NM_145563.2_3 - 1.5e-08 34.5 88.7 0.0072 16.3 1.7 11.5 2 2 11 13 13 13 10 Zinc ribbon domain XPA_N PF01286.16 NM_145563.2_3 - 1.2e-05 25.1 65.1 1.2 9.1 0.1 14.7 15 0 0 15 15 15 3 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_145563.2_3 - 8.3e-05 23.1 73.0 0.71 10.5 2.4 8.1 1 1 5 9 9 9 8 zinc-ribbon family C1_4 PF07975.10 NM_145563.2_3 - 0.00025 21.1 89.3 0.6 10.3 6.0 11.6 1 1 12 14 14 14 5 TFIIH C1-like domain DUF3268 PF11672.6 NM_145563.2_3 - 0.00031 20.9 65.3 0.081 13.1 2.5 8.4 2 1 9 12 12 12 7 zinc-finger-containing domain SprT-like PF10263.7 NM_145563.2_3 - 0.00035 20.3 91.5 0.089 12.5 4.9 7.9 1 1 6 7 7 7 3 SprT-like family zf-trcl PF13451.4 NM_145563.2_3 - 0.0032 17.2 73.0 1.3 8.8 3.4 12.7 11 4 1 12 12 12 3 Probable zinc-ribbon domain BDHCT_assoc PF16204.3 NM_145563.2_3 - 2.5 7.6 8.8 13 5.2 0.7 4.2 1 1 6 7 7 7 0 BDHCT-box associated domain on Bloom syndrome protein ZZ PF00569.15 NM_145563.2_3 - 6.2 6.6 75.0 14 5.5 0.1 14.5 16 0 0 16 16 16 0 Zinc finger, ZZ type TMCCDC2 PF15844.3 NM_026300.2_3 - 0.016 15.0 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 Transmembrane and coiled-coil domain-containing protein 2 DUF1180 PF06679.10 NM_026300.2_3 - 0.047 14.0 0.2 0.089 13.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Guanylate_cyc PF00211.18 NM_009624.3_2 - 5.6e-115 381.2 0.8 2.9e-62 209.4 0.2 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF512 PF04459.10 NM_009624.3_2 - 0.066 12.4 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF512) DUF1053 PF06327.12 NM_009624.3_2 - 0.087 13.2 0.2 0.25 11.8 0.2 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) AC_N PF16214.3 NM_009624.3_2 - 0.23 10.4 5.7 0.18 10.8 0.0 3.0 3 0 0 3 3 3 0 Adenylyl cyclase N-terminal extracellular and transmembrane region zf-MYND PF01753.16 NM_001282072.1_2 - 8.8e-10 38.4 15.8 2.3e-09 37.0 15.8 1.8 1 0 0 1 1 1 1 MYND finger SAND PF01342.19 NM_001282072.1_3 - 1.4e-26 91.9 0.0 2.3e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 SAND domain HAGH_C PF16123.3 NM_001271436.1_3 - 5.5e-21 74.8 0.0 9.2e-21 74.0 0.0 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 NM_001271436.1_3 - 1.1e-07 31.9 5.3 2.9e-06 27.3 5.3 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 NM_001271436.1_3 - 0.013 14.9 0.3 0.031 13.7 0.2 1.7 2 0 0 2 2 2 0 Beta-lactamase superfamily domain RBM1CTR PF08081.9 NM_172635.3_1 - 1.2 9.1 4.2 3.1 7.8 4.2 1.6 1 0 0 1 1 1 0 RBM1CTR (NUC064) family PAT1 PF09770.7 NM_172635.3_3 - 2.7e-17 62.3 14.5 3.9e-15 55.1 0.2 3.6 3 1 0 3 3 3 3 Topoisomerase II-associated protein PAT1 SHMT PF00464.17 NM_009171.2_1 - 8.4e-210 696.2 0.0 9.9e-210 696.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.19 NM_009171.2_1 - 0.00066 18.8 0.0 0.001 18.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DZF PF07528.12 NM_001034895.3_1 - 7.1e-57 192.7 0.0 9.9e-57 192.3 0.0 1.2 1 0 0 1 1 1 1 DZF domain zf-met PF12874.5 NM_001034895.3_1 - 1.3e-19 69.8 14.0 1.1e-06 28.7 1.2 3.7 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 NM_001034895.3_1 - 5.1e-13 48.8 6.3 9.5e-05 22.5 0.3 3.5 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 NM_001034895.3_1 - 0.00024 21.2 12.3 0.66 10.2 0.3 3.6 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) V1R PF03402.12 NM_001166725.1_1 - 2.7e-15 56.6 13.0 3.8e-15 56.1 13.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001166725.1_1 - 9.5e-15 54.3 15.8 1.4e-14 53.8 15.8 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001166725.1_1 - 2.1e-06 27.1 13.8 2.7e-06 26.7 13.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Peptidase_M7 PF02031.14 NM_001166725.1_1 - 0.023 14.7 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family PRP8_domainIV PF12134.6 NM_001166725.1_1 - 0.091 12.3 0.2 0.57 9.7 0.0 2.0 2 0 0 2 2 2 0 PRP8 domain IV core Anoctamin PF04547.10 NM_001166725.1_1 - 0.14 10.7 6.7 0.029 13.0 3.1 1.5 1 1 0 1 1 1 0 Calcium-activated chloride channel DUF1700 PF08006.9 NM_001166725.1_1 - 0.28 10.6 6.2 0.28 10.6 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Fer4_4 PF12800.5 NM_001166725.1_3 - 0.53 10.8 0.1 0.53 10.8 0.1 4.8 5 0 0 5 5 5 0 4Fe-4S binding domain CITED PF04487.10 NM_001276466.1_1 - 8.9e-31 107.4 0.1 1.3e-30 106.8 0.1 1.3 1 1 0 1 1 1 1 CITED zf-H2C2_5 PF13909.4 NM_199027.2_3 - 1.1e-33 114.5 70.1 1.5e-07 30.9 4.9 9.9 9 0 0 9 9 9 8 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 NM_199027.2_3 - 2.4e-25 87.4 113.5 0.00047 20.3 0.5 13.4 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_199027.2_3 - 5.6e-25 85.7 104.3 0.00034 21.1 0.5 13.6 13 0 0 13 13 13 12 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_199027.2_3 - 4.3e-23 80.5 97.0 2.2e-06 27.7 1.5 14.2 15 0 0 15 15 15 8 Zinc-finger double domain zf-C2H2_6 PF13912.4 NM_199027.2_3 - 1.4e-07 31.2 2.4 2.2e-05 24.1 0.1 8.6 8 0 0 8 8 8 3 C2H2-type zinc finger ADK_lid PF05191.12 NM_199027.2_3 - 0.0038 17.1 3.2 0.0038 17.1 3.2 4.4 5 0 0 5 5 5 1 Adenylate kinase, active site lid zf-C2H2_2 PF12756.5 NM_199027.2_3 - 0.089 13.0 0.1 0.089 13.0 0.1 10.5 3 2 5 9 9 9 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.6 NM_199027.2_3 - 0.78 10.0 0.0 0.78 10.0 0.0 8.6 9 1 1 10 10 10 0 Zinc-finger double-stranded RNA-binding Arc_PepC_II PF06847.9 NM_029256.3_3 - 6.2 7.3 7.2 0.29 11.6 0.7 2.0 2 1 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II S_100 PF01023.17 NM_009114.3_1 - 1.2e-20 72.7 0.1 2.3e-20 71.9 0.1 1.5 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 NM_009114.3_1 - 4.3e-06 25.7 1.9 0.00012 21.2 0.7 2.4 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.4 NM_009114.3_1 - 0.0011 18.2 0.8 0.03 13.7 0.2 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.4 NM_009114.3_1 - 0.0024 18.2 0.3 0.0036 17.6 0.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.5 NM_009114.3_1 - 0.0024 17.7 0.2 0.0038 17.0 0.2 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_6 PF13405.4 NM_009114.3_1 - 0.0032 17.2 0.2 0.13 12.1 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 NM_009114.3_1 - 0.015 14.9 1.7 0.031 13.9 1.7 1.6 1 1 0 1 1 1 0 EF-hand domain pair Pox_D5 PF03288.14 NM_009114.3_1 - 0.045 14.1 0.1 0.079 13.3 0.1 1.4 1 0 0 1 1 1 0 Poxvirus D5 protein-like DEK_C PF08766.9 NM_009114.3_1 - 0.054 13.3 0.2 0.1 12.4 0.2 1.5 1 0 0 1 1 1 0 DEK C terminal domain Cnd1 PF12717.5 NM_009114.3_1 - 0.076 12.9 0.8 0.1 12.5 0.8 1.2 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Sulfotransfer_3 PF13469.4 NM_001326590.1_2 - 1.6e-58 198.5 0.0 2.4e-58 198.0 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.25 NM_001326590.1_2 - 1.2e-07 31.4 0.0 6.5e-07 29.0 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase domain DAO PF01266.22 NM_001316718.1_1 - 4.9e-11 42.7 0.0 6.5e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 NM_001316718.1_1 - 0.0043 16.2 0.0 0.0069 15.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 NM_001316718.1_1 - 0.0061 16.7 0.3 0.025 14.7 0.1 2.3 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.15 NM_001316718.1_1 - 0.055 12.6 0.1 0.11 11.6 0.0 1.4 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.25 NM_001316718.1_1 - 0.058 13.8 0.1 0.11 12.9 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RRM_1 PF00076.20 NM_001033408.4_2 - 3.6e-08 33.0 0.0 9.9e-08 31.6 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4577 PF15145.4 NM_001033437.2_1 - 9.6e-69 229.2 0.2 1.3e-68 228.8 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) DUF4714 PF15833.3 NM_001033437.2_1 - 0.004 17.0 0.0 0.01 15.7 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4714) CCDC85 PF10226.7 NM_001033437.2_1 - 0.053 13.1 0.2 0.083 12.4 0.2 1.2 1 0 0 1 1 1 0 CCDC85 family PsbT PF01405.15 NM_001033437.2_1 - 5.4 6.8 7.9 13 5.6 7.9 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre T protein 7tm_4 PF13853.4 NM_146747.1_1 - 1.5e-52 178.9 26.8 1.8e-52 178.7 26.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146747.1_1 - 4.8e-20 71.8 25.5 8.5e-20 71.0 25.5 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146747.1_1 - 0.0032 16.7 28.2 0.0053 16.0 28.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Dysbindin PF04440.14 NM_001048227.1_2 - 4.7e-29 101.3 1.4 7.3e-29 100.7 1.4 1.2 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) PLU-1 PF08429.9 NM_152895.2_3 - 1.1e-91 307.4 14.4 2.1e-88 296.5 7.7 3.4 3 1 0 3 3 3 2 PLU-1-like protein JmjC PF02373.20 NM_152895.2_3 - 5.3e-44 149.2 1.5 1.1e-43 148.2 1.5 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.27 NM_152895.2_3 - 7.9e-28 96.0 33.5 1.1e-11 44.3 4.1 4.5 3 0 0 3 3 3 3 PHD-finger ARID PF01388.19 NM_152895.2_3 - 1.4e-16 60.8 0.0 3.8e-16 59.4 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-C5HC2 PF02928.14 NM_152895.2_3 - 1.1e-14 54.3 11.8 1.1e-14 54.3 11.8 3.0 2 0 0 2 2 2 1 C5HC2 zinc finger JmjN PF02375.15 NM_152895.2_3 - 3.1e-14 52.5 0.8 6.4e-14 51.5 0.8 1.6 1 0 0 1 1 1 1 jmjN domain PHD_2 PF13831.4 NM_152895.2_3 - 4.7e-06 25.9 23.4 0.031 13.7 6.1 4.2 3 0 0 3 3 3 3 PHD-finger zf-PHD-like PF15446.4 NM_152895.2_3 - 0.048 13.1 12.9 0.22 11.0 0.6 3.7 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain FYVE_2 PF02318.14 NM_152895.2_3 - 0.059 13.4 30.9 0.051 13.6 2.1 4.8 4 0 0 4 4 4 0 FYVE-type zinc finger Zf_RING PF16744.3 NM_152895.2_3 - 1.9 8.5 10.2 1 9.4 0.7 3.6 3 0 0 3 3 3 0 KIAA1045 RING finger Dynein_IC2 PF11540.6 NM_001198874.1_3 - 9.3e-16 57.3 0.6 2.3e-15 56.1 0.6 1.7 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 NM_001198874.1_3 - 1e-05 26.1 11.6 0.19 12.5 0.6 6.9 7 0 0 7 7 7 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001198874.1_3 - 0.0037 17.4 0.1 0.05 13.8 0.0 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4329 PF14220.4 NM_001198874.1_3 - 0.16 11.8 0.4 21 5.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4329) Ras PF00071.20 NM_016899.4_1 - 1.2e-55 187.4 0.2 1.4e-55 187.1 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_016899.4_1 - 5.6e-31 107.1 0.1 8.8e-31 106.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_016899.4_1 - 9e-12 44.7 0.1 1.2e-11 44.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_016899.4_1 - 6e-07 29.4 0.0 1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_016899.4_1 - 7.1e-05 22.6 0.3 0.023 14.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 NM_016899.4_1 - 0.0012 18.1 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 NM_016899.4_1 - 0.0027 17.0 0.0 0.0051 16.1 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.4 NM_016899.4_1 - 0.0075 16.4 0.1 0.024 14.8 0.1 1.9 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.4 NM_016899.4_1 - 0.023 14.6 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 NM_016899.4_1 - 0.023 14.9 0.1 0.035 14.3 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.4 NM_016899.4_1 - 0.051 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.4 NM_016899.4_1 - 0.06 13.5 0.6 1.4 9.0 0.1 2.2 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.7 NM_016899.4_1 - 0.067 12.8 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.12 NM_016899.4_1 - 0.089 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.25 NM_016899.4_1 - 0.11 12.8 0.1 0.21 12.0 0.1 1.6 1 1 0 1 1 1 0 ABC transporter KAP_NTPase PF07693.12 NM_016899.4_1 - 0.16 11.1 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain TniB PF05621.9 NM_016899.4_1 - 0.16 11.0 0.0 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Septin PF00735.16 NM_016899.4_1 - 0.18 10.9 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Septin RasGEF PF00617.17 NM_001039087.1_2 - 9.2e-52 175.6 0.4 3.8e-51 173.6 0.1 2.0 1 1 1 2 2 2 1 RasGEF domain RasGEF_N PF00618.18 NM_001039087.1_2 - 2.3e-09 37.3 0.2 2.3e-09 37.3 0.2 2.1 3 0 0 3 3 3 1 RasGEF N-terminal motif Med26 PF08711.9 NM_025617.2_3 - 2.4e-11 43.4 0.0 5.6e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain AAA_16 PF13191.4 NM_173437.2_3 - 0.0008 19.7 0.0 0.002 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 NM_173437.2_3 - 0.01 15.9 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.4 NM_173437.2_3 - 0.015 15.4 0.0 0.029 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.15 NM_173437.2_3 - 0.015 14.9 0.0 0.027 14.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.14 NM_173437.2_3 - 0.017 14.4 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA PF00004.27 NM_173437.2_3 - 0.021 15.1 0.0 0.048 14.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.20 NM_173437.2_3 - 0.034 14.4 0.0 0.082 13.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.4 NM_173437.2_3 - 0.066 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.18 NM_173437.2_3 - 0.069 12.1 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.4 NM_173437.2_3 - 0.094 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.12 NM_173437.2_3 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF258 PF03193.14 NM_173437.2_3 - 0.12 12.1 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 CwsA PF10814.6 NM_173437.2_3 - 0.14 12.2 0.4 0.35 10.9 0.4 1.6 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA DUF4407 PF14362.4 NM_173437.2_3 - 4.8 6.3 5.8 8.8 5.4 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Carb_anhydrase PF00194.19 NM_001083957.1_2 - 1.6e-92 309.5 0.0 1.9e-92 309.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Trypsin PF00089.24 NM_010114.2_3 - 1.1e-69 234.5 0.0 1.3e-69 234.3 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_010114.2_3 - 1.1e-06 28.8 0.1 0.00032 20.9 0.3 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_010114.2_3 - 3e-06 28.0 0.0 5.6e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain Cupin_8 PF13621.4 NM_029842.5_3 - 4e-45 154.4 0.1 5.2e-45 154.1 0.1 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.10 NM_029842.5_3 - 4.8e-09 36.0 0.1 8.5e-09 35.2 0.1 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.20 NM_029842.5_3 - 0.0027 18.0 0.0 0.0063 16.8 0.0 1.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.9 NM_029842.5_3 - 0.016 14.8 0.0 0.09 12.4 0.0 2.2 2 1 0 2 2 2 0 Cupin domain DUF4606 PF15379.4 NM_001039220.3_3 - 1.3e-43 147.3 0.1 1.3e-43 147.3 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4606) Cyclin PF08613.9 NM_001039220.3_3 - 0.17 12.1 0.9 0.39 10.9 0.9 1.9 1 1 0 1 1 1 0 Cyclin zf-C2H2 PF00096.24 NM_001291026.1_1 - 1.6e-40 135.2 87.5 1.4e-06 28.3 1.4 10.9 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001291026.1_1 - 1.1e-25 88.7 74.7 9.6e-08 32.0 1.2 12.4 12 0 0 12 12 12 6 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001291026.1_1 - 5.7e-25 85.7 86.3 0.0021 18.6 0.7 11.7 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001291026.1_1 - 3.4e-05 23.9 56.6 0.15 12.3 0.3 10.0 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 NM_001291026.1_1 - 0.00012 21.6 2.4 0.00012 21.6 2.4 8.7 10 0 0 10 10 10 4 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.3 NM_001291026.1_1 - 0.0002 20.9 51.1 0.16 11.6 2.8 8.9 9 0 0 9 9 8 4 zinc-finger C2H2-type SET PF00856.26 NM_001291026.1_1 - 0.0016 18.7 0.0 0.0047 17.2 0.0 1.8 1 0 0 1 1 1 1 SET domain zf-BED PF02892.13 NM_001291026.1_1 - 0.0016 18.3 0.7 0.0016 18.3 0.7 7.2 3 3 5 8 8 8 3 BED zinc finger zf-C2H2_6 PF13912.4 NM_001291026.1_1 - 0.0092 15.8 75.4 0.25 11.2 0.3 10.6 11 0 0 11 11 11 7 C2H2-type zinc finger zf-C2H2_8 PF15909.3 NM_001291026.1_1 - 1 9.5 38.3 1.4 9.2 11.2 4.6 2 1 3 5 5 5 0 C2H2-type zinc ribbon PyrI_C PF02748.13 NM_001291026.1_1 - 4.5 7.1 21.3 1.3 8.8 0.1 5.2 4 1 1 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain OTU PF02338.17 NM_130880.1_1 - 4e-24 85.4 0.0 7.2e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease zf-A20 PF01754.14 NM_130880.1_1 - 9.1e-06 25.4 5.5 1.8e-05 24.4 5.5 1.5 1 0 0 1 1 1 1 A20-like zinc finger UBA_4 PF14555.4 NM_130880.1_1 - 0.00013 21.6 0.0 0.00024 20.7 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.11 NM_130880.1_1 - 0.017 14.6 0.0 0.037 13.5 0.0 1.5 1 0 0 1 1 1 0 TAP C-terminal domain DTW PF03942.13 NM_026981.2_3 - 1.5e-43 148.7 0.0 2.2e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 DTW domain CD225 PF04505.10 NM_001101546.1_2 - 3.1e-20 71.9 1.3 5.5e-20 71.1 1.3 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF4190 PF13828.4 NM_001101546.1_2 - 0.0029 17.2 1.0 0.012 15.2 1.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4190) RRM_1 PF00076.20 NM_026043.3_3 - 5.3e-18 64.5 0.1 3.3e-08 33.1 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_026043.3_3 - 0.02 14.4 0.1 1.5 8.3 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 NM_026043.3_3 - 0.085 12.8 0.0 10 6.1 0.0 2.4 2 0 0 2 2 2 0 Limkain b1 GTF2I PF02946.12 NM_001081467.2_2 - 1.5e-154 502.2 8.3 1.8e-31 107.9 0.1 5.3 5 0 0 5 5 5 5 GTF2I-like repeat KCNQ_channel PF03520.12 NM_010611.3_3 - 4.3e-88 294.0 0.1 5.9e-88 293.6 0.1 1.2 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel KCNQC3-Ank-G_bd PF11956.6 NM_010611.3_3 - 9.2e-46 154.3 0.6 1.7e-45 153.4 0.6 1.4 1 0 0 1 1 1 1 Ankyrin-G binding motif of KCNQ2-3 KCNQ2_u3 PF16642.3 NM_010611.3_3 - 1.1e-35 122.3 11.1 2.5e-35 121.2 11.1 1.6 1 0 0 1 1 1 1 Unstructured region on Potassium channel subunit alpha KvLQT2 Ion_trans PF00520.29 NM_010611.3_3 - 4.4e-29 101.3 7.2 9.2e-29 100.2 7.2 1.5 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 NM_010611.3_3 - 2.5e-12 46.5 3.3 5.5e-12 45.4 3.3 1.6 1 0 0 1 1 1 1 Ion channel Connexin PF00029.17 NM_001159382.1_2 - 4.3e-99 330.7 0.3 7.7e-99 329.9 0.3 1.4 1 0 0 1 1 1 1 Connexin TLP-20 PF06088.9 NM_001159382.1_2 - 0.049 13.4 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Connexin40_C PF16791.3 NM_001159382.1_2 - 1.5 10.0 4.7 0.33 12.1 0.3 2.0 2 0 0 2 2 2 0 Connexin 40 C-terminal domain FAM27 PF15832.3 NM_001291104.1_1 - 5.9e-05 23.4 12.1 0.00015 22.1 12.1 1.6 1 0 0 1 1 1 1 FAM27 D and E protein family Apis_Csd PF11671.6 NM_001291104.1_1 - 0.037 13.9 0.7 0.037 13.9 0.7 1.9 2 0 0 2 2 2 0 Complementary sex determiner protein DUF3915 PF13054.4 NM_001291104.1_1 - 0.053 13.4 3.5 0.1 12.4 3.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FGF PF00167.16 NM_001291104.1_2 - 2.2e-22 79.3 0.0 1.5e-15 57.2 0.0 2.2 1 1 1 2 2 2 2 Fibroblast growth factor FAM27 PF15832.3 NM_001291104.1_2 - 4.1e-06 27.1 6.6 8e-06 26.2 6.6 1.4 1 0 0 1 1 1 1 FAM27 D and E protein family Fascin PF06268.11 NM_001291104.1_2 - 0.0031 17.6 0.0 0.0071 16.4 0.0 1.5 1 1 0 1 1 1 1 Fascin domain Atrophin-1 PF03154.13 NM_001291104.1_2 - 2.6 6.1 6.7 4.2 5.4 6.7 1.2 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 NM_001291104.1_2 - 5.1 7.0 7.1 8.8 6.2 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 NM_001291104.1_3 - 0.0013 19.1 14.7 0.0024 18.2 14.7 1.3 1 0 0 1 1 1 1 FAM27 D and E protein family DUF3915 PF13054.4 NM_001291104.1_3 - 4.2 7.2 7.3 6.8 6.6 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) PAS_3 PF08447.10 NM_001162950.1_2 - 5e-21 74.7 0.0 4.2e-15 55.7 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 NM_001162950.1_2 - 2.3e-18 66.2 0.0 5.4e-15 55.4 0.0 2.4 2 0 0 2 2 2 2 PAS domain HIF-1 PF11413.6 NM_001162950.1_2 - 2.7e-14 52.1 5.9 5.3e-14 51.2 5.9 1.5 1 0 0 1 1 1 1 Hypoxia-inducible factor-1 PAS PF00989.23 NM_001162950.1_2 - 5.7e-14 52.0 0.0 4.5e-06 26.5 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.8 NM_001162950.1_2 - 5.8e-07 29.6 0.0 0.025 14.7 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.5 NM_001162950.1_2 - 8.5e-06 25.9 0.0 0.1 12.7 0.0 2.3 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 NM_001162950.1_2 - 0.049 13.5 0.3 0.088 12.7 0.3 1.4 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain TMEM154 PF15102.4 NM_177260.2_2 - 1.1e-46 158.1 3.7 1.6e-46 157.6 3.7 1.2 1 0 0 1 1 1 1 TMEM154 protein family DUF4448 PF14610.4 NM_177260.2_2 - 0.015 15.0 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF3377 PF11857.6 NM_177260.2_2 - 0.18 11.6 0.5 0.43 10.4 0.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3377) SKG6 PF08693.8 NM_177260.2_2 - 3.8 6.9 6.0 0.26 10.6 0.4 2.0 2 0 0 2 2 2 0 Transmembrane alpha-helix domain IIGP PF05049.11 NM_173434.1_1 - 2e-123 412.0 0.1 3.1e-123 411.4 0.1 1.3 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.21 NM_173434.1_1 - 4.1e-11 42.8 0.0 8e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_173434.1_1 - 3.5e-06 26.9 0.5 9.2e-06 25.5 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Dynamin_N PF00350.21 NM_173434.1_1 - 1.8e-05 24.7 0.1 0.016 15.1 0.2 2.5 1 1 1 2 2 2 2 Dynamin family ABC_tran PF00005.25 NM_173434.1_1 - 7.6e-05 23.1 0.0 0.00019 21.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.4 NM_173434.1_1 - 0.0011 19.3 0.0 0.0044 17.3 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain FeoB_N PF02421.16 NM_173434.1_1 - 0.0073 15.7 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_29 PF13555.4 NM_173434.1_1 - 0.013 15.1 0.1 0.027 14.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DLIC PF05783.9 NM_173434.1_1 - 0.014 14.1 0.1 0.024 13.4 0.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AIG1 PF04548.14 NM_173434.1_1 - 0.026 13.7 0.0 0.044 13.0 0.0 1.4 1 0 0 1 1 1 0 AIG1 family Roc PF08477.11 NM_173434.1_1 - 0.069 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.4 NM_173434.1_1 - 0.39 11.1 0.1 0.39 11.1 0.1 2.0 3 0 0 3 3 3 0 AAA domain HMG_box PF00505.17 NM_011445.4_2 - 1.1e-21 76.9 4.5 2.4e-21 75.8 4.5 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_011445.4_2 - 8.3e-09 35.8 1.1 8.3e-09 35.8 1.1 2.3 2 0 0 2 2 2 1 HMG-box domain MPS2 PF17060.3 NM_011445.4_2 - 0.24 10.5 10.9 0.38 9.8 10.9 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 ING PF12998.5 NM_025454.2_3 - 1.3e-30 105.9 5.8 1.8e-30 105.4 5.8 1.2 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.27 NM_025454.2_3 - 3.1e-05 23.6 13.4 4.3e-05 23.2 8.1 2.8 2 0 0 2 2 2 1 PHD-finger DUF4515 PF14988.4 NM_025454.2_3 - 0.059 13.1 3.2 0.091 12.5 3.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) Spc7 PF08317.9 NM_025454.2_3 - 0.34 9.6 4.7 0.48 9.1 4.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein 7tm_4 PF13853.4 NM_146823.1_1 - 5.9e-47 160.6 19.5 7.7e-47 160.2 19.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146823.1_1 - 2.7e-14 52.9 24.4 7.2e-14 51.5 23.6 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146823.1_1 - 0.56 9.4 28.0 1.1 8.4 26.2 2.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Ribosomal_S28e PF01200.16 NM_016844.2_3 - 8.2e-35 118.5 0.9 1e-34 118.2 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S28e Guanylate_kin PF00625.19 NM_001159320.2_2 - 4.7e-50 169.7 0.9 6.6e-50 169.2 0.3 1.6 2 0 0 2 2 2 1 Guanylate kinase VGCC_beta4Aa_N PF12052.6 NM_001159320.2_2 - 1.8e-22 79.0 6.2 4.3e-22 77.8 6.2 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.26 NM_001159320.2_2 - 0.00065 19.1 0.1 0.0024 17.3 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 NM_001159320.2_2 - 0.056 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain SH3_2 PF07653.15 NM_001159320.2_2 - 0.065 12.8 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Variant SH3 domain DUF2315 PF10231.7 NM_001163388.1_1 - 4e-43 146.4 2.6 5.2e-43 146.0 2.6 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2315) Tctex-1 PF03645.11 NM_025975.5_2 - 2e-24 85.6 2.2 4.3e-24 84.6 1.0 2.1 2 0 0 2 2 2 1 Tctex-1 family Acetyltransf_1 PF00583.23 NM_019870.3_1 - 2.4e-15 56.7 0.0 3.9e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 NM_019870.3_1 - 2.1e-10 40.5 0.0 3.8e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 NM_019870.3_1 - 2.3e-08 34.2 0.0 3.9e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 NM_019870.3_1 - 1.3e-07 31.4 0.0 2.9e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.5 NM_019870.3_1 - 0.0011 18.9 0.1 0.0025 17.8 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.3 NM_019870.3_1 - 0.0016 17.8 0.1 0.003 16.9 0.1 1.3 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_13 PF13880.4 NM_019870.3_1 - 0.0058 16.5 0.1 0.0099 15.7 0.1 1.3 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_3 PF13302.5 NM_019870.3_1 - 0.0079 16.7 0.0 0.022 15.3 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain UPF0193 PF05250.9 NM_138581.2_2 - 3.2e-88 295.0 4.1 4e-88 294.7 4.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) Myb_DNA-bind_5 PF13873.4 NM_138581.2_2 - 0.1 12.5 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain SPATA3 PF15662.3 NM_027029.2_3 - 1.2e-73 247.8 19.9 1.5e-73 247.4 19.9 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated protein 3 family ESP PF16590.3 NM_001244651.1_1 - 3.1e-21 75.3 0.0 4.9e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Exocrine gland-secreting peptide ABC2_membrane PF01061.22 NM_138955.3_1 - 9.7e-47 159.0 25.5 1.5e-46 158.4 25.5 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.25 NM_138955.3_1 - 1.3e-24 87.1 0.0 2e-24 86.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 NM_138955.3_1 - 8.7e-06 25.6 0.0 0.0067 16.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 NM_138955.3_1 - 3.9e-05 23.1 0.1 0.00038 19.8 0.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF258 PF03193.14 NM_138955.3_1 - 0.0046 16.7 0.0 0.0079 16.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_13 PF13166.4 NM_138955.3_1 - 0.031 12.8 0.0 0.095 11.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.4 NM_138955.3_1 - 0.076 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.5 NM_138955.3_1 - 0.079 11.9 22.5 0.019 14.0 18.3 1.8 1 1 1 2 2 2 0 ABC-2 family transporter protein ArgK PF03308.14 NM_138955.3_1 - 0.084 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 ArgK protein MMR_HSR1 PF01926.21 NM_138955.3_1 - 0.087 12.8 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.4 NM_138955.3_1 - 0.18 12.2 0.0 0.31 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Thioredoxin_6 PF13848.4 NM_027943.1_2 - 4.7e-33 114.6 12.8 1e-32 113.5 6.9 3.1 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin PF00085.18 NM_027943.1_2 - 1.6e-23 82.5 0.5 6.7e-14 51.6 0.0 4.0 4 0 0 4 4 4 3 Thioredoxin OST3_OST6 PF04756.11 NM_027943.1_2 - 3.6e-05 23.1 3.5 0.069 12.3 0.5 3.1 2 1 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.4 NM_027943.1_2 - 0.0022 18.1 0.8 0.92 9.7 0.0 3.7 3 2 1 4 4 4 1 Thioredoxin-like Thioredoxin_2 PF13098.4 NM_027943.1_2 - 0.0049 17.2 3.1 1.3 9.4 0.0 3.7 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_7 PF13899.4 NM_027943.1_2 - 0.011 15.8 0.0 0.85 9.7 0.0 3.3 3 0 0 3 3 3 0 Thioredoxin-like ERp29_N PF07912.11 NM_027943.1_2 - 0.012 15.6 0.2 6.1 6.9 0.0 3.2 3 0 0 3 3 3 0 ERp29, N-terminal domain mRNA_cap_enzyme PF01331.17 NM_001305273.1_1 - 4.3e-77 258.2 0.3 5.9e-77 257.8 0.3 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.13 NM_001305273.1_1 - 1.5e-13 51.2 0.0 2.5e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DSPc PF00782.18 NM_001305273.1_1 - 2.6e-10 40.1 0.0 5.8e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DNA_ligase_A_M PF01068.19 NM_001305273.1_1 - 0.0012 18.4 0.0 0.16 11.5 0.0 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain Y_phosphatase PF00102.25 NM_001305273.1_1 - 0.0039 16.7 0.0 0.0068 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase p450 PF00067.20 NM_009995.2_1 - 2e-95 320.1 0.0 2.5e-95 319.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cullin PF00888.20 NM_009995.2_1 - 0.091 11.2 0.1 0.11 10.9 0.1 1.1 1 0 0 1 1 1 0 Cullin family T-box PF00907.20 NM_001290747.1_1 - 1.2e-26 94.0 0.1 1.8e-26 93.4 0.1 1.3 1 0 0 1 1 1 1 T-box T-box PF00907.20 NM_001290747.1_3 - 1.1e-14 54.9 0.0 1.7e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 T-box NDUFA12 PF05071.14 NM_025551.3_1 - 2.8e-29 101.6 5.6 3.6e-29 101.3 5.6 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Longin PF13774.4 NM_001164562.1_2 - 9.1e-10 38.3 0.0 1.5e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Presenilin PF01080.15 NM_001164562.1_3 - 0.0096 14.6 4.6 0.015 13.9 4.6 1.2 1 0 0 1 1 1 1 Presenilin zf-H2C2_2 PF13465.4 NM_172586.4_2 - 2.5e-44 147.6 80.8 1.6e-07 31.3 1.1 12.4 11 1 0 11 11 11 8 Zinc-finger double domain zf-C2H2 PF00096.24 NM_172586.4_2 - 8.1e-37 123.5 75.6 4.1e-05 23.7 0.2 11.1 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_172586.4_2 - 3.6e-10 39.6 93.5 0.006 17.2 0.2 11.5 11 0 0 11 11 11 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_172586.4_2 - 1.9e-05 24.3 44.3 0.0064 16.3 0.7 8.8 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_172586.4_2 - 0.048 13.9 49.3 0.19 11.9 0.2 9.1 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding Pkinase PF00069.23 NM_009863.3_1 - 2.2e-45 154.9 0.0 1.4e-25 90.0 0.2 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 NM_009863.3_1 - 7.3e-16 58.1 0.0 5.4e-13 48.7 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.21 NM_009863.3_1 - 0.03 14.1 0.0 1.6 8.5 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Peptidase_C74 PF12387.6 NM_009863.3_2 - 0.012 15.0 1.2 0.019 14.3 1.2 1.2 1 0 0 1 1 1 0 Pestivirus NS2 peptidase VGPC1_C PF16799.3 NM_001042489.2_2 - 1.3e-26 92.2 7.2 2.6e-26 91.2 7.2 1.6 1 0 0 1 1 1 1 C-terminal membrane-localisation domain of ion-channel, VCN1 Ion_trans PF00520.29 NM_001042489.2_2 - 3.5e-07 29.6 11.8 5e-07 29.1 11.8 1.1 1 0 0 1 1 1 1 Ion transport protein Homeobox PF00046.27 NM_001085348.1_2 - 1.4e-12 47.1 1.1 2.1e-12 46.5 1.1 1.2 1 0 0 1 1 1 1 Homeobox domain YdaS_antitoxin PF15943.3 NM_001085348.1_2 - 0.17 11.7 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Surp PF01805.18 NM_026476.2_1 - 1.4e-18 66.5 0.2 3.8e-18 65.1 0.2 1.8 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.20 NM_026476.2_1 - 9.4e-15 54.1 0.0 1.7e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cwf21 PF08312.10 NM_026476.2_1 - 1.4e-09 37.8 2.6 5.9e-09 35.8 2.6 2.2 1 0 0 1 1 1 1 cwf21 domain CTK3 PF12243.6 NM_026476.2_1 - 0.00013 21.8 0.1 0.0003 20.7 0.1 1.5 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTD_bind PF04818.11 NM_026476.2_1 - 0.006 17.3 0.2 0.016 15.9 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. SET_assoc PF11767.6 NM_026476.2_1 - 0.034 13.6 0.2 0.095 12.2 0.1 1.8 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Glycos_transf_2 PF00535.24 NM_172451.3_1 - 2.3e-33 115.2 0.0 3.5e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 NM_172451.3_1 - 6.3e-24 84.5 0.4 1.2e-23 83.6 0.4 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 NM_172451.3_1 - 2.4e-08 33.4 0.0 6.3e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 NM_172451.3_1 - 0.011 15.1 0.0 0.033 13.5 0.0 1.6 2 0 0 2 2 2 0 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.4 NM_172451.3_1 - 0.048 14.3 0.0 9.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like IIGP PF05049.11 NM_001101475.2_2 - 2.3e-128 428.3 3.0 2.8e-128 428.0 3.0 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.21 NM_001101475.2_2 - 7e-09 35.7 0.0 1.2e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.25 NM_001101475.2_2 - 6.2e-05 23.4 0.0 0.00011 22.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter Dynamin_N PF00350.21 NM_001101475.2_2 - 0.00012 22.0 0.7 0.0086 16.0 0.5 2.5 1 1 1 2 2 2 1 Dynamin family Tox-PLDMTX PF15645.4 NM_001101475.2_2 - 0.00032 20.7 0.0 0.00056 19.9 0.0 1.4 1 0 0 1 1 1 1 Dermonecrotoxin of the Papain-like fold DUF258 PF03193.14 NM_001101475.2_2 - 0.0015 18.3 0.0 0.0033 17.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 NM_001101475.2_2 - 0.0025 17.4 0.1 0.0047 16.5 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Roc PF08477.11 NM_001101475.2_2 - 0.0045 17.1 0.0 0.0086 16.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.16 NM_001101475.2_2 - 0.0066 15.9 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.4 NM_001101475.2_2 - 0.033 14.4 0.0 0.059 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AIG1 PF04548.14 NM_001101475.2_2 - 0.096 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 AIG1 family Ras PF00071.20 NM_001101475.2_2 - 0.098 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Ras family AAA_22 PF13401.4 NM_001101475.2_2 - 0.14 12.3 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.17 NM_001101475.2_2 - 0.16 11.4 0.1 0.3 10.5 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Transposase_22 PF02994.12 NM_001101475.2_3 - 3.4e-32 111.6 7.5 4.3e-32 111.2 7.5 1.1 1 0 0 1 1 1 1 L1 transposable element Abhydrolase_2 PF02230.14 NM_145545.4_1 - 0.0004 20.1 0.0 0.00065 19.4 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_2 PF02230.14 NM_145545.4_2 - 5.5e-11 42.6 0.0 3e-10 40.1 0.0 1.9 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase GBP_C PF02841.12 NM_145545.4_3 - 5.8e-124 413.2 26.7 5.8e-124 413.2 26.7 2.1 2 0 0 2 2 2 1 Guanylate-binding protein, C-terminal domain GBP PF02263.17 NM_145545.4_3 - 6.6e-124 412.2 0.0 1.6e-123 411.0 0.0 1.6 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Abhydrolase_2 PF02230.14 NM_145545.4_3 - 7.1e-07 29.1 0.2 0.0022 17.7 0.0 2.5 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase MMR_HSR1 PF01926.21 NM_145545.4_3 - 0.05 13.6 1.7 0.05 13.6 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF1438 PF07270.9 NM_001039648.3_2 - 4.7e-89 296.1 1.7 6.1e-89 295.7 1.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1438) Ribosomal_L7Ae PF01248.24 NM_001037166.2_2 - 3.5e-27 93.8 2.2 5.1e-27 93.3 2.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ski_Sno PF02437.15 NM_033605.2_1 - 6.2e-37 125.6 0.1 1.8e-36 124.1 0.1 1.8 1 0 0 1 1 1 1 SKI/SNO/DAC family Macoilin PF09726.7 NM_033605.2_1 - 0.00073 18.1 9.4 0.0015 17.1 9.4 1.4 1 0 0 1 1 1 1 Transmembrane protein adh_short PF00106.23 NM_001301367.1_1 - 6.4e-35 120.3 0.3 9.5e-35 119.7 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_001301367.1_1 - 2.4e-30 105.7 0.4 3.7e-30 105.1 0.4 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.15 NM_001301367.1_1 - 4.5e-25 87.9 0.2 8e-25 87.1 0.2 1.4 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.8 NM_001301367.1_1 - 6.6e-05 22.8 0.2 0.00014 21.7 0.2 1.5 1 0 0 1 1 1 1 KR domain Alkyl_sulf_C PF14864.4 NM_001301367.1_1 - 0.0037 17.4 0.0 0.007 16.5 0.0 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal DUF2000 PF09391.8 NM_001301367.1_1 - 0.037 13.8 0.1 0.068 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) NAD_binding_3 PF03447.14 NM_001301367.1_1 - 0.41 11.2 1.5 8.9 6.9 0.2 2.4 1 1 1 2 2 2 0 Homoserine dehydrogenase, NAD binding domain DUF1387 PF07139.9 NM_001301367.1_1 - 1.7 8.1 9.1 2.6 7.5 9.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) FOXP-CC PF16159.3 NM_053242.4_3 - 1.3e-34 118.4 4.2 1.3e-34 118.4 4.2 4.1 2 1 2 4 4 4 1 FOXP coiled-coil domain Forkhead PF00250.16 NM_053242.4_3 - 1.7e-27 95.4 0.2 4.4e-27 94.1 0.2 1.7 1 0 0 1 1 1 1 Forkhead domain Galactosyl_T PF01762.19 NM_016888.5_3 - 2.1e-40 138.5 0.0 2.9e-40 138.1 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 NM_016888.5_3 - 0.011 15.1 0.0 0.017 14.5 0.0 1.1 1 0 0 1 1 1 0 Fringe-like DUF604 PF04646.10 NM_016888.5_3 - 0.035 13.3 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF604 AA_permease_2 PF13520.4 NM_001286385.1_1 - 8.2e-33 113.7 18.3 1e-32 113.4 18.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 NM_001286385.1_1 - 1.2e-07 30.6 17.3 1.4e-07 30.4 17.3 1.1 1 0 0 1 1 1 1 Amino acid permease Fibrinogen_C PF00147.16 NM_010584.3_3 - 3.1e-05 23.7 0.3 5.5e-05 22.9 0.3 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.16 NM_010584.3_3 - 0.014 14.6 0.1 0.022 13.9 0.1 1.2 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain HECT PF00632.23 NM_008395.3_3 - 2.3e-97 326.1 0.1 3.1e-97 325.6 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 NM_008395.3_3 - 4.6e-46 154.3 18.6 1.6e-14 53.4 0.9 4.6 4 0 0 4 4 4 4 WW domain C2 PF00168.28 NM_008395.3_3 - 3.4e-14 52.8 0.4 6.6e-14 51.9 0.4 1.4 1 0 0 1 1 1 1 C2 domain Rad51 PF08423.9 NM_020570.2_1 - 1e-15 57.6 0.0 1.5e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 NM_020570.2_1 - 0.0017 17.8 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain DnaJ PF00226.29 NM_008929.3_2 - 6.5e-22 77.3 3.2 6.5e-22 77.3 3.2 2.5 3 0 0 3 3 2 1 DnaJ domain TPR_1 PF00515.26 NM_008929.3_2 - 1.2e-21 75.4 17.6 4.3e-06 26.2 0.0 7.7 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.4 NM_008929.3_2 - 8.1e-20 71.0 15.6 0.00012 22.4 0.2 6.5 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.15 NM_008929.3_2 - 9.4e-19 65.8 14.4 0.00096 19.0 0.0 8.6 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_16 PF13432.4 NM_008929.3_2 - 1.3e-14 54.4 14.3 0.00011 22.6 0.9 5.7 6 1 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.4 NM_008929.3_2 - 4.8e-14 51.2 12.9 0.0022 18.0 0.0 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.4 NM_008929.3_2 - 1e-11 44.2 10.7 0.0044 16.5 0.3 5.4 4 1 1 5 5 5 3 TPR repeat TPR_9 PF13371.4 NM_008929.3_2 - 3e-11 43.2 3.9 0.00014 21.8 0.1 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_008929.3_2 - 3e-10 39.9 23.2 0.031 14.9 0.8 7.8 5 3 5 10 10 8 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_008929.3_2 - 4.7e-09 36.3 7.3 0.94 9.7 0.1 5.6 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.4 NM_008929.3_2 - 5.5e-09 35.7 7.1 0.044 14.0 0.0 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_21 PF09976.7 NM_008929.3_2 - 4.3e-06 26.5 3.5 4.3e-06 26.5 3.5 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat-like domain ANAPC3 PF12895.5 NM_008929.3_2 - 3.4e-05 23.8 11.3 0.038 14.1 0.2 4.3 2 1 4 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.4 NM_008929.3_2 - 5e-05 23.4 17.1 0.36 11.1 0.3 5.6 3 2 2 5 5 5 2 Tetratricopeptide repeat PRAI PF00697.20 NM_008929.3_2 - 0.016 14.8 0.2 0.026 14.1 0.2 1.2 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase TPR_6 PF13174.4 NM_008929.3_2 - 0.023 15.2 14.3 1.8 9.3 0.0 6.8 8 0 0 8 8 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_008929.3_2 - 0.046 13.6 7.3 9.4 6.3 0.5 4.8 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.4 NM_008929.3_2 - 0.16 11.7 1.9 3.3 7.6 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Ras PF00071.20 NM_028024.2_3 - 1e-24 86.9 0.1 1.3e-24 86.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_028024.2_3 - 3.3e-10 40.1 0.0 5.6e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_028024.2_3 - 1.2e-06 27.9 0.0 1.6e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_028024.2_3 - 0.00017 21.5 0.0 0.00026 20.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 NM_028024.2_3 - 0.00076 18.9 0.1 0.042 13.3 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.21 NM_028024.2_3 - 0.0023 17.9 0.2 0.0054 16.7 0.2 1.5 1 1 0 1 1 1 1 Dynamin family DUF2121 PF09894.7 NM_028024.2_3 - 0.031 13.7 0.1 0.12 11.8 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2121) DUF258 PF03193.14 NM_028024.2_3 - 0.082 12.7 0.2 3.4 7.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 LRR_8 PF13855.4 NM_027413.1_3 - 1.9e-13 49.8 9.5 1.1e-06 28.2 6.0 2.6 1 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 NM_027413.1_3 - 1.5e-10 40.9 6.1 0.00019 21.6 1.2 2.9 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_027413.1_3 - 0.00015 21.6 4.2 1.3 9.7 0.1 5.0 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_9 PF14580.4 NM_027413.1_3 - 0.0015 18.0 1.6 0.0027 17.1 1.2 1.6 1 1 0 1 1 1 1 Leucine-rich repeat G-alpha PF00503.18 NM_008138.4_3 - 1.1e-124 416.1 2.7 1.4e-124 415.8 2.7 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 NM_008138.4_3 - 7e-17 61.3 0.1 2.1e-12 46.7 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_008138.4_3 - 6.6e-05 22.2 1.8 0.062 12.5 0.9 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 NM_008138.4_3 - 0.0006 19.9 0.1 1.2 9.2 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 NM_008138.4_3 - 0.042 14.1 0.0 0.08 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Y_phosphatase PF00102.25 NM_008982.5_1 - 2.5e-82 275.9 0.5 3.7e-82 275.3 0.5 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.19 NM_008982.5_1 - 2.1e-42 143.2 24.3 1.5e-06 28.4 0.1 10.6 10 1 0 10 10 10 8 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_008982.5_1 - 8.4e-09 35.8 12.8 0.024 15.0 0.1 6.7 3 2 2 5 5 5 3 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 NM_008982.5_1 - 1.4e-06 28.6 4.0 1.5 9.2 0.0 5.0 4 1 0 4 4 4 3 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 NM_008982.5_1 - 0.00016 21.8 6.4 4.3 7.6 0.0 5.8 6 1 0 7 7 7 2 Interferon-alpha/beta receptor, fibronectin type III DSPc PF00782.18 NM_008982.5_1 - 0.0031 17.2 0.0 0.0061 16.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 NM_008982.5_1 - 0.0048 16.7 0.0 0.0086 15.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_008982.5_1 - 0.012 15.6 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Ank_2 PF12796.5 NM_023729.3_2 - 1.3e-39 134.5 4.4 2.8e-15 56.5 0.3 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.28 NM_023729.3_2 - 7.6e-25 86.1 0.7 6.3e-07 29.4 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.4 NM_023729.3_2 - 2.4e-24 85.3 0.4 1.2e-11 44.7 0.0 4.6 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_023729.3_2 - 7.9e-24 83.2 1.7 4.7e-10 39.4 0.1 5.0 3 2 3 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_023729.3_2 - 1.1e-20 71.3 0.3 5.5e-05 23.1 0.0 6.4 7 0 0 7 7 7 3 Ankyrin repeat SAM_2 PF07647.15 NM_023729.3_2 - 3.2e-10 39.8 0.2 7.9e-10 38.6 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_023729.3_2 - 2.5e-06 27.7 0.8 6e-06 26.5 0.8 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DASH_Dad4 PF08650.8 NM_023729.3_2 - 0.23 11.3 1.3 0.81 9.6 0.2 2.4 3 0 0 3 3 3 0 DASH complex subunit Dad4 RabGAP-TBC PF00566.16 NM_001252640.1_3 - 1.3e-08 34.7 0.2 2.4e-06 27.3 0.1 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain 7tm_3 PF00003.20 NM_053118.1_1 - 7.7e-25 87.9 32.5 1.1e-24 87.4 32.3 1.3 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR SKG6 PF08693.8 NM_053118.1_1 - 0.12 11.7 3.6 0.53 9.6 3.6 2.2 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF1345 PF07077.9 NM_053118.1_1 - 2 8.0 16.6 0.089 12.3 3.0 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) DnaJ PF00226.29 NM_001253685.1_2 - 1.2e-13 50.8 0.1 1.2e-13 50.8 0.1 2.0 2 0 0 2 2 2 1 DnaJ domain Histone_H2A_C PF16211.3 NM_013549.2_1 - 2.2e-20 71.9 2.4 3.8e-20 71.2 2.4 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 NM_013549.2_1 - 7.8e-17 61.8 0.0 1.1e-16 61.3 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_013549.2_1 - 2.1e-05 24.6 0.0 3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone V1R PF03402.12 NM_030738.2_2 - 5.4e-13 49.0 11.9 8.1e-13 48.5 11.9 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_030738.2_2 - 7e-11 41.7 15.7 1e-10 41.1 15.7 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MRI PF15325.4 NM_199145.2_3 - 2.1e-44 150.9 0.5 4.6e-44 149.8 0.5 1.6 1 0 0 1 1 1 1 Modulator of retrovirus infection zf-H2C2_2 PF13465.4 NM_177359.5_3 - 7e-84 272.7 127.0 3.4e-07 30.3 1.3 17.3 17 0 0 17 17 16 16 Zinc-finger double domain zf-C2H2 PF00096.24 NM_177359.5_3 - 1.4e-52 173.2 136.0 0.00014 22.0 0.1 17.9 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_177359.5_3 - 4.5e-46 151.4 130.6 0.0023 18.5 1.1 17.9 16 0 0 16 16 16 16 C2H2-type zinc finger KRAB PF01352.25 NM_177359.5_3 - 7.9e-18 63.7 0.4 1.4e-17 63.0 0.4 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_177359.5_3 - 3e-17 62.0 109.2 0.011 15.5 2.8 16.9 16 0 0 16 16 16 14 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_177359.5_3 - 9.6e-11 41.5 73.9 0.059 13.4 2.3 10.7 6 3 6 12 12 12 9 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_177359.5_3 - 9.5e-10 38.4 82.6 0.057 13.6 0.2 16.0 16 0 0 16 16 16 7 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 NM_177359.5_3 - 9.4e-06 25.3 67.6 0.012 15.3 0.9 13.4 13 3 0 13 13 13 3 Probable zinc-ribbon domain DUF3268 PF11672.6 NM_177359.5_3 - 0.0017 18.6 55.3 0.17 12.1 0.7 8.6 5 3 6 11 11 11 6 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 NM_177359.5_3 - 0.0036 17.9 63.9 0.19 12.3 1.2 8.5 3 2 5 8 8 8 2 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_177359.5_3 - 2.5 7.8 103.4 0.061 13.0 1.6 14.9 16 0 0 16 16 16 0 zinc-finger C2H2-type AAA_16 PF13191.4 NM_001167883.1_2 - 0.0033 17.7 0.0 0.018 15.3 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.10 NM_001167883.1_2 - 0.26 11.1 1.6 0.4 10.4 0.5 1.9 2 1 0 2 2 2 0 NACHT domain FUN14 PF04930.13 NM_028058.4_2 - 1.5e-27 95.7 2.6 2.3e-27 95.1 2.6 1.3 1 0 0 1 1 1 1 FUN14 family DSPc PF00782.18 NM_175118.3_1 - 9.8e-27 93.2 0.0 1.2e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.10 NM_175118.3_1 - 0.056 13.6 0.0 0.091 12.9 0.0 1.2 1 0 0 1 1 1 0 Rit1 DUSP-like domain TRAM_LAG1_CLN8 PF03798.14 NM_026884.1_2 - 1e-44 152.6 12.8 1.8e-44 151.8 12.8 1.3 1 0 0 1 1 1 1 TLC domain DUF3487 PF11990.6 NM_026884.1_2 - 0.03 14.1 0.2 0.091 12.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) Pkinase PF00069.23 NM_001291778.1_2 - 2.2e-56 191.0 0.0 2.8e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001291778.1_2 - 1.1e-38 132.9 0.0 1.4e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001291778.1_2 - 3e-08 33.2 0.0 4.5e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.9 NM_001291778.1_2 - 0.0029 16.6 0.0 0.0055 15.7 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.21 NM_001291778.1_2 - 0.053 13.3 0.0 0.081 12.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family 7tm_4 PF13853.4 NM_147063.2_1 - 1.3e-58 198.8 24.0 1.6e-58 198.5 24.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147063.2_1 - 4.6e-27 94.8 18.9 8.5e-27 93.9 18.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147063.2_1 - 0.012 14.8 17.2 0.018 14.3 17.2 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx zf-H2C2_2 PF13465.4 NM_001112805.1_3 - 2.5e-73 239.3 98.4 1.3e-08 34.7 2.2 13.4 13 0 0 13 13 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001112805.1_3 - 5.2e-52 171.4 93.2 2.3e-05 24.4 0.7 12.2 12 0 0 12 12 12 11 Zinc finger, C2H2 type KRAB PF01352.25 NM_001112805.1_3 - 3.1e-23 81.0 1.1 2.3e-22 78.2 0.1 2.3 2 0 0 2 2 2 1 KRAB box zf-C2H2_4 PF13894.4 NM_001112805.1_3 - 1.3e-18 65.9 93.9 0.029 15.1 0.5 12.5 12 0 0 12 12 12 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001112805.1_3 - 1.9e-10 40.6 50.6 0.03 14.3 4.0 7.1 4 1 4 8 8 8 8 Zinc ribbon domain XPA_N PF01286.16 NM_001112805.1_3 - 1.1e-06 28.4 42.4 6.8 6.7 0.3 11.3 11 0 0 11 11 11 5 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_001112805.1_3 - 0.00022 21.8 42.9 0.52 11.0 0.8 6.3 1 1 7 8 8 8 6 zinc-ribbon family zf-C2H2_6 PF13912.4 NM_001112805.1_3 - 0.0017 18.1 85.9 0.22 11.4 0.2 12.5 13 0 0 13 13 13 8 C2H2-type zinc finger C1_4 PF07975.10 NM_001112805.1_3 - 0.057 13.6 47.7 2.1 8.5 0.0 7.1 4 1 4 8 8 8 0 TFIIH C1-like domain zf-C2H2_jaz PF12171.6 NM_001112805.1_3 - 0.063 13.5 59.1 0.48 10.7 0.1 10.8 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding Nucleoporin2 PF04096.12 NM_022979.2_1 - 5.6e-41 139.8 0.0 9.4e-41 139.1 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.4 NM_022979.2_1 - 2.2e-06 28.3 195.0 0.00048 20.8 30.5 7.0 2 2 5 7 7 7 5 Nucleoporin FG repeat region HTH_psq PF05225.14 NM_172154.4_2 - 8.9e-14 50.8 0.0 1.6e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Anillin_N PF16018.3 NM_028390.3_1 - 3.8e-46 155.5 7.7 2.7e-37 127.1 1.4 3.5 2 0 0 2 2 2 2 Anillin N-terminus Anillin PF08174.9 NM_028390.3_1 - 2.1e-39 135.1 0.3 2.1e-39 135.1 0.3 1.8 2 0 0 2 2 2 1 Cell division protein anillin PH PF00169.27 NM_028390.3_1 - 1.9e-15 57.1 0.9 5e-15 55.8 0.2 2.2 2 0 0 2 2 2 1 PH domain Dynamin_N PF00350.21 NM_001243040.1_1 - 0.00033 20.6 0.0 0.00033 20.6 0.0 3.4 4 0 0 4 4 4 1 Dynamin family MMR_HSR1 PF01926.21 NM_001243040.1_1 - 0.002 18.0 0.1 0.013 15.4 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Exo_endo_phos PF03372.21 NM_009213.2_3 - 3e-10 40.2 0.0 4.7e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TIR_2 PF13676.4 NM_054096.2_1 - 7.1e-11 42.2 0.0 1.2e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 TIR domain TIR PF01582.18 NM_054096.2_1 - 2.9e-05 23.8 0.1 6e-05 22.8 0.0 1.6 2 0 0 2 2 2 1 TIR domain SRP-alpha_N PF04086.11 NM_054096.2_2 - 3.3 7.4 4.8 5.3 6.7 4.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TPR_1 PF00515.26 NM_008995.2_1 - 6.5e-24 82.6 1.3 4.9e-06 26.0 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.15 NM_008995.2_1 - 4.9e-20 69.8 4.0 0.00091 19.0 0.2 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.4 NM_008995.2_1 - 8.6e-18 63.6 0.3 3.3e-05 23.4 0.1 6.0 3 1 3 6 6 6 3 TPR repeat TPR_8 PF13181.4 NM_008995.2_1 - 2.1e-17 61.7 0.1 0.0013 18.7 0.1 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.4 NM_008995.2_1 - 5.4e-16 57.6 0.5 0.011 16.0 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.4 NM_008995.2_1 - 3.8e-14 52.0 8.5 0.014 16.0 0.2 6.7 4 1 2 6 6 5 4 Tetratricopeptide repeat TPR_16 PF13432.4 NM_008995.2_1 - 4.6e-13 49.5 5.6 1.2e-05 25.8 0.3 4.6 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.4 NM_008995.2_1 - 1.2e-11 44.8 2.5 0.0013 19.1 1.4 3.8 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_008995.2_1 - 1.2e-10 41.4 4.2 9.6e-06 25.7 1.8 3.8 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_008995.2_1 - 2e-09 36.7 0.7 0.031 14.2 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_008995.2_1 - 4.2e-07 29.9 5.0 0.016 15.2 1.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.4 NM_008995.2_1 - 4.6e-06 26.2 2.3 0.019 14.7 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_008995.2_1 - 5.9e-06 26.4 0.8 3.1 8.5 0.1 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_20 PF14561.4 NM_008995.2_1 - 1.1e-05 25.5 0.2 0.14 12.3 0.0 3.8 2 2 2 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_008995.2_1 - 1.6e-05 24.9 1.6 0.02 14.9 0.1 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.4 NM_008995.2_1 - 0.026 13.6 6.5 1 8.4 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1641 PF07849.9 NM_008995.2_1 - 0.14 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) SHNi-TPR PF10516.7 NM_008995.2_1 - 1.4 8.3 4.2 56 3.2 0.0 3.9 4 0 0 4 4 4 0 SHNi-TPR Pkinase_Tyr PF07714.15 NM_001287261.1_2 - 3.4e-89 298.4 0.0 4.3e-89 298.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001287261.1_2 - 3.8e-38 131.2 0.0 5.3e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 NM_001287261.1_2 - 0.0021 17.3 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF1510 PF07423.9 NM_001287261.1_2 - 0.092 12.0 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CD34_antigen PF06365.10 NM_001287261.1_2 - 0.13 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family MAGE PF01454.17 NM_001199997.1_1 - 2.2e-15 56.8 0.1 4.6e-13 49.2 0.0 2.6 2 1 0 2 2 2 1 MAGE family PI3K_1B_p101 PF10486.7 NM_001199997.1_1 - 0.073 10.7 11.0 0.11 10.1 11.0 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF2151 PF10221.7 NM_001199997.1_1 - 0.097 11.0 6.7 0.13 10.6 6.7 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Isy1 PF06246.10 NM_001199997.1_1 - 0.13 11.7 11.8 0.17 11.3 11.8 1.1 1 0 0 1 1 1 0 Isy1-like splicing family Nop14 PF04147.10 NM_001199997.1_1 - 0.17 9.9 21.2 0.24 9.5 21.2 1.1 1 0 0 1 1 1 0 Nop14-like family Lin-8 PF03353.13 NM_001199997.1_1 - 0.41 10.0 12.9 0.62 9.5 12.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SDA1 PF05285.10 NM_001199997.1_1 - 0.68 9.2 20.5 0.93 8.7 20.5 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.12 NM_001199997.1_1 - 0.74 7.9 13.3 1.1 7.4 13.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.8 NM_001199997.1_1 - 1.1 9.5 10.6 1.7 8.8 10.6 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 COPI_C PF06957.9 NM_001199997.1_1 - 1.1 7.8 10.5 1.8 7.2 10.5 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus TFIIF_alpha PF05793.10 NM_001199997.1_1 - 1.8 7.0 22.4 2.6 6.4 22.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF1510 PF07423.9 NM_001199997.1_1 - 2.8 7.2 21.8 4.7 6.5 21.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF913 PF06025.10 NM_001199997.1_1 - 2.9 6.6 6.4 4 6.2 6.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.15 NM_001199997.1_1 - 4.5 5.8 6.8 6.6 5.2 6.8 1.2 1 0 0 1 1 1 0 Presenilin BUD22 PF09073.8 NM_001199997.1_1 - 4.6 6.3 22.4 6.3 5.9 22.4 1.1 1 0 0 1 1 1 0 BUD22 RNA_pol_Rpc4 PF05132.12 NM_001199997.1_1 - 4.6 7.5 8.4 7.8 6.8 8.4 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Tim54 PF11711.6 NM_001199997.1_1 - 5.2 5.6 9.8 8 5.0 9.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Peptidase_S64 PF08192.9 NM_001199997.1_1 - 5.9 5.1 10.7 8.3 4.6 10.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 TRAP_alpha PF03896.14 NM_001199997.1_1 - 6.2 5.8 10.8 10 5.1 10.8 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Macoilin PF09726.7 NM_001199997.1_1 - 8 4.7 9.8 11 4.3 9.8 1.1 1 0 0 1 1 1 0 Transmembrane protein DDRGK PF09756.7 NM_001199997.1_1 - 8.4 5.8 22.3 15 5.0 22.3 1.2 1 0 0 1 1 1 0 DDRGK domain IRF-2BP1_2 PF11261.6 NM_178757.3_1 - 6.1e-34 115.2 0.9 1.2e-33 114.3 0.9 1.5 1 0 0 1 1 1 1 Interferon regulatory factor 2-binding protein zinc finger zf-C3HC4 PF00097.23 NM_178757.3_1 - 0.00015 21.4 2.5 0.00035 20.2 2.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_178757.3_1 - 0.062 13.0 6.9 0.21 11.4 6.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_178757.3_1 - 1.9 8.7 8.4 5 7.3 8.4 1.8 1 0 0 1 1 1 0 Ring finger domain Lipocalin PF00061.21 NM_010694.1_2 - 3.2e-21 75.9 0.0 4e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Reticulon PF02453.15 NM_001271486.1_2 - 2.6e-42 144.3 11.5 4.3e-42 143.6 11.5 1.4 1 0 0 1 1 1 1 Reticulon cNMP_binding PF00027.27 NM_001253890.1_1 - 4.4e-40 135.5 0.0 6.7e-20 70.8 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 NM_001253890.1_1 - 1.8e-13 49.7 0.2 3.7e-13 48.8 0.2 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Oxysterol_BP PF01237.16 NM_001252493.1_2 - 3.4e-152 506.4 0.3 4.4e-152 506.1 0.3 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein PDZ PF00595.22 NM_001199272.1_2 - 2.5e-16 59.7 0.3 4.2e-16 58.9 0.3 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001199272.1_2 - 0.00022 21.3 0.0 0.00049 20.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DUF903 PF06004.10 NM_001199272.1_2 - 0.11 12.3 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) MAGSP PF03082.12 NM_001199272.1_2 - 0.67 9.4 2.8 1.6 8.2 1.1 2.0 2 0 0 2 2 2 0 Male accessory gland secretory protein DUF4140 PF13600.4 NM_001199272.1_2 - 1.2 9.5 6.2 19 5.6 1.7 2.4 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.13 NM_001199272.1_2 - 1.4 8.6 8.1 8.5 6.1 1.8 2.6 2 0 0 2 2 2 0 Septum formation initiator HALZ PF02183.16 NM_001199272.1_2 - 4.1 7.6 9.3 3.6 7.8 0.1 2.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper ST7 PF04184.10 NM_001289627.1_1 - 4.8e-303 1005.4 1.1 8.8e-303 1004.5 1.1 1.3 1 1 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 NM_001289627.1_1 - 0.00064 20.1 0.0 0.0035 17.7 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001289627.1_1 - 0.0062 16.4 0.2 5.2 7.3 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.18 NM_001289627.1_1 - 0.068 12.9 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 NM_001289627.1_1 - 0.15 12.4 4.6 0.43 11.0 0.4 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001289627.1_1 - 0.73 10.7 5.8 16 6.5 0.0 4.4 3 2 1 4 4 4 0 Tetratricopeptide repeat zf-C2H2 PF00096.24 NM_009537.3_1 - 2.1e-16 59.2 24.2 4.7e-05 23.5 0.4 5.0 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_009537.3_1 - 9.9e-12 44.6 5.7 5.9e-07 29.5 0.2 5.0 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_009537.3_1 - 0.046 14.4 0.2 0.046 14.4 0.2 5.6 5 0 0 5 5 5 0 C2H2-type zinc finger zf-CGNR PF11706.6 NM_009537.3_1 - 0.15 11.8 2.7 12 5.7 0.4 3.0 2 1 0 2 2 2 0 CGNR zinc finger IBR PF01485.19 NM_009537.3_1 - 0.17 12.0 6.3 0.12 12.5 2.7 2.4 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain CCAP PF11105.6 NM_009537.3_1 - 0.78 9.6 4.5 3.2 7.6 0.9 2.2 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a SelP_N PF04592.12 NM_009537.3_1 - 3.1 7.0 12.3 6.1 6.0 12.3 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region GRP PF07172.9 NM_009537.3_1 - 9.4 6.9 37.7 0.59 10.7 9.5 2.3 2 0 0 2 2 2 0 Glycine rich protein family RhoGEF PF00621.18 NM_001145452.1_1 - 2e-13 50.9 1.6 2e-13 50.9 1.6 2.3 2 0 0 2 2 2 1 RhoGEF domain Spc7 PF08317.9 NM_001145452.1_1 - 0.012 14.4 14.8 0.018 13.8 14.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Tup_N PF08581.8 NM_001145452.1_1 - 0.018 15.2 0.9 0.018 15.2 0.9 2.5 1 1 1 2 2 2 0 Tup N-terminal ArsR PF09824.7 NM_001145452.1_1 - 0.029 13.8 1.2 0.052 13.0 1.2 1.3 1 0 0 1 1 1 0 ArsR transcriptional regulator Muted PF14942.4 NM_001145452.1_1 - 0.15 12.2 10.7 0.47 10.6 10.7 1.9 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF1664 PF07889.10 NM_001145452.1_1 - 0.21 11.4 3.2 0.41 10.5 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.13 NM_001145452.1_1 - 1.1 8.6 6.4 2.1 7.7 6.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit COG2 PF06148.9 NM_001145452.1_1 - 1.5 8.8 8.7 1.5 8.8 6.3 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Cluap1 PF10234.7 NM_001145452.1_1 - 1.7 7.8 12.8 2.9 7.1 12.8 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 HAUS6_N PF14661.4 NM_001145452.1_1 - 2.2 7.7 12.3 0.27 10.7 7.4 1.9 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 6 N-terminus NEP PF10167.7 NM_001145452.1_1 - 2.4 8.0 12.0 0.59 10.0 7.4 2.3 2 1 0 2 2 2 0 Uncharacterised conserved protein Seryl_tRNA_N PF02403.20 NM_001145452.1_1 - 3.1 7.9 13.6 2.9 8.0 10.9 2.3 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain SR-25 PF10500.7 NM_001099217.1_1 - 1 8.8 21.9 1.4 8.4 21.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.9 NM_001099217.1_1 - 1.8 8.7 16.9 2.4 8.3 16.9 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Med19 PF10278.7 NM_001099217.1_1 - 6.2 6.6 21.4 8.7 6.1 21.4 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 TSGP1 PF07771.9 NM_001099217.1_1 - 6.6 6.8 13.1 9.7 6.2 13.1 1.2 1 0 0 1 1 1 0 Tick salivary peptide group 1 UPAR_LY6 PF00021.19 NM_001099217.1_3 - 2.4e-14 53.7 9.0 4.4e-14 52.8 9.0 1.5 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Toxin_1 PF00087.19 NM_001099217.1_3 - 0.00017 21.6 9.0 0.00037 20.5 9.0 1.6 1 0 0 1 1 1 1 Snake toxin UPAR_LY6_2 PF16975.3 NM_001099217.1_3 - 0.056 13.5 4.4 0.13 12.3 4.4 1.6 1 0 0 1 1 1 0 Ly6/PLAUR domain-containing protein 6, Lypd6 Sec7 PF01369.18 NM_001163548.1_2 - 4.2e-66 222.0 0.1 5.9e-66 221.6 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 NM_001163548.1_2 - 5.5e-28 97.4 0.1 1e-27 96.6 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_001163548.1_2 - 0.00041 20.6 0.1 0.001 19.3 0.1 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain RINGv PF12906.5 NM_001166375.1_2 - 2.4e-15 56.2 16.4 6e-15 55.0 16.4 1.7 1 0 0 1 1 1 1 RING-variant domain CENP-T_C PF15511.4 NM_178208.2_1 - 2.3e-08 34.0 0.1 2.9e-08 33.6 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.15 NM_178208.2_1 - 3.6e-05 23.7 0.1 5.1e-05 23.2 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.4 NM_178208.2_1 - 6.9e-05 23.0 0.1 9.6e-05 22.6 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.22 NM_178208.2_1 - 0.00029 21.1 0.3 0.00034 20.9 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_178208.2_1 - 0.00041 20.4 0.1 0.00069 19.7 0.1 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.13 NM_178208.2_1 - 0.0074 16.2 0.0 0.0088 16.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.11 NM_178208.2_1 - 0.034 14.0 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated SNF PF00209.16 NM_001136087.2_2 - 4.2e-151 504.1 26.4 2.9e-123 412.2 15.7 2.1 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family PAP2 PF01569.19 NM_029425.3_2 - 6.2e-21 74.5 1.2 1.3e-20 73.4 1.2 1.5 1 0 0 1 1 1 1 PAP2 superfamily CDRT4 PF15213.4 NM_025496.1_3 - 5e-58 195.4 0.5 6.9e-58 195.0 0.5 1.2 1 0 0 1 1 1 1 CMT1A duplicated region transcript 4 protein 7tm_1 PF00001.19 NM_020621.4_1 - 5.5e-39 133.9 18.0 5.5e-39 133.9 18.0 2.1 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) DCX PF03607.15 NM_001177964.2_2 - 7.2e-11 41.9 0.0 1.1e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Doublecortin RA PF00788.21 NM_010806.1_2 - 9.3e-48 160.7 0.0 7.1e-24 84.1 0.0 2.7 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain DIL PF01843.17 NM_010806.1_2 - 9.4e-31 106.1 2.0 1.5e-30 105.4 0.5 2.1 2 0 0 2 2 2 1 DIL domain PDZ PF00595.22 NM_010806.1_2 - 8.6e-17 61.1 0.5 1.7e-16 60.2 0.5 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FHA PF00498.24 NM_010806.1_2 - 1.4e-07 31.6 0.0 3.1e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.3 NM_010806.1_2 - 0.0012 19.0 0.0 0.0041 17.3 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain PDZ_2 PF13180.4 NM_010806.1_2 - 0.0017 18.5 0.4 0.0053 16.9 0.4 1.8 1 0 0 1 1 1 1 PDZ domain Cyt-b5 PF00173.26 NM_025797.3_3 - 8.1e-23 80.2 0.1 1.1e-22 79.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Aminotran_1_2 PF00155.19 NM_173866.3_3 - 5.4e-32 111.2 0.0 6.9e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II NmrA PF05368.11 NM_001290763.1_3 - 1.7e-50 171.6 0.0 2.1e-50 171.3 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.4 NM_001290763.1_3 - 4.5e-13 49.4 0.1 6.1e-13 48.9 0.1 1.1 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.8 NM_001290763.1_3 - 0.00043 20.1 0.2 0.00069 19.4 0.2 1.2 1 0 0 1 1 1 1 KR domain TrkA_N PF02254.16 NM_001290763.1_3 - 0.00044 20.4 0.2 0.00087 19.4 0.2 1.4 1 1 0 1 1 1 1 TrkA-N domain Epimerase PF01370.19 NM_001290763.1_3 - 0.0024 17.2 0.1 0.0034 16.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.15 NM_001290763.1_3 - 0.0085 16.5 0.1 0.017 15.6 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.23 NM_001290763.1_3 - 0.013 14.8 1.5 0.013 14.8 0.6 1.4 2 0 0 2 2 2 0 short chain dehydrogenase HTH_3 PF01381.20 NM_001290763.1_3 - 0.034 14.1 0.1 0.061 13.2 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix 3Beta_HSD PF01073.17 NM_001290763.1_3 - 0.037 12.9 0.0 0.049 12.5 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Shikimate_DH PF01488.18 NM_001290763.1_3 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Defensin_beta_2 PF13841.4 NM_183035.1_1 - 2.2e-06 27.9 9.1 3.6e-06 27.2 9.1 1.4 1 0 0 1 1 1 1 Beta defensin 7tm_4 PF13853.4 NM_146739.1_1 - 9.5e-54 182.9 18.5 1.1e-53 182.6 18.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146739.1_1 - 5.2e-23 81.5 19.8 9.3e-23 80.7 19.8 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1517 PF07466.9 NM_146739.1_1 - 0.073 12.1 0.2 0.17 10.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) LRR_4 PF12799.5 NM_001085418.2_1 - 4e-06 26.9 4.8 2.3 8.6 0.0 6.2 5 2 1 6 6 6 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 NM_001085418.2_1 - 0.095 12.7 0.1 11 6.2 0.0 3.8 4 0 0 4 4 4 0 Leucine Rich repeat Galactosyl_T PF01762.19 NM_028189.3_1 - 3.2e-41 141.2 0.0 4.3e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 NM_028189.3_1 - 0.00092 18.6 0.0 0.0017 17.7 0.0 1.4 2 0 0 2 2 2 1 Fringe-like Tektin PF03148.12 NM_027951.1_1 - 3.1e-139 463.8 34.2 3.6e-139 463.7 34.2 1.0 1 0 0 1 1 1 1 Tektin family Med9 PF07544.11 NM_027951.1_1 - 0.00036 20.4 11.8 0.32 11.0 0.3 3.7 3 0 0 3 3 3 2 RNA polymerase II transcription mediator complex subunit 9 NEP PF10167.7 NM_027951.1_1 - 0.0029 17.4 4.6 1.4 8.7 0.1 3.5 3 0 0 3 3 3 1 Uncharacterised conserved protein Mating_N PF12731.5 NM_027951.1_1 - 0.03 14.3 1.5 0.056 13.4 0.2 2.1 2 0 0 2 2 2 0 Mating-type protein beta 1 Baculo_PEP_C PF04513.10 NM_027951.1_1 - 0.052 13.4 5.7 0.088 12.7 0.6 2.6 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus BST2 PF16716.3 NM_027951.1_1 - 0.15 12.5 22.1 0.061 13.8 3.3 4.1 4 0 0 4 4 4 0 Bone marrow stromal antigen 2 DUF445 PF04286.10 NM_027951.1_1 - 0.33 10.6 7.0 0.73 9.5 6.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF445) EBP50_C PF09007.9 NM_027951.1_1 - 1.1 10.1 3.8 5.9 7.8 0.1 2.8 2 1 0 2 2 2 0 EBP50, C-terminal TMF_DNA_bd PF12329.6 NM_027951.1_1 - 1.1 9.2 14.2 0.82 9.6 2.6 3.3 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF2730 PF10805.6 NM_027951.1_1 - 1.2 9.2 4.8 15 5.6 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) ATG16 PF08614.9 NM_027951.1_1 - 1.5 8.8 26.4 0.31 11.1 1.6 3.8 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Spc24 PF08286.9 NM_027951.1_1 - 1.6 8.9 17.6 0.08 13.1 0.8 3.6 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 MitMem_reg PF13012.4 NM_027951.1_1 - 2.6 8.4 6.4 8 6.8 1.9 3.3 2 2 0 2 2 2 0 Maintenance of mitochondrial structure and function Sec2p PF06428.9 NM_027951.1_1 - 5.4 6.9 11.5 2.7 7.8 0.8 3.3 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p Noelin-1 PF12308.6 NM_027951.1_1 - 6.5 6.7 8.6 4.5 7.2 0.5 3.2 3 0 0 3 3 3 0 Neurogenesis glycoprotein TBPIP PF07106.11 NM_027951.1_1 - 8.5 6.0 17.0 0.6 9.7 1.3 3.5 3 1 1 4 4 4 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Myb_DNA-binding PF00249.29 NM_172562.3_2 - 2e-11 43.7 0.1 5.5e-11 42.3 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.15 NM_172562.3_2 - 6e-08 32.8 0.0 2.3e-07 30.9 0.0 1.9 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-bind_6 PF13921.4 NM_172562.3_2 - 1.2e-05 25.4 0.6 4.3e-05 23.5 0.1 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain GHBP PF12772.5 NM_001286370.1_1 - 1.6e-129 431.6 5.1 2.1e-129 431.2 5.1 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.8 NM_001286370.1_1 - 1.5e-10 41.1 1.8 3.3e-09 36.7 1.8 2.7 1 1 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 NM_001286370.1_1 - 0.019 15.2 0.1 0.04 14.1 0.1 1.5 1 0 0 1 1 1 0 Fibronectin type III domain 7tm_2 PF00002.22 NM_011199.2_1 - 1.6e-90 302.6 13.0 2.1e-90 302.2 13.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_011199.2_1 - 3.7e-19 68.7 2.9 7.9e-19 67.6 2.9 1.6 1 0 0 1 1 1 1 Hormone receptor domain An_peroxidase PF03098.13 NM_011198.4_2 - 5.5e-53 180.2 0.0 1.4e-45 155.7 0.0 2.2 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.25 NM_011198.4_2 - 3.7e-05 23.8 13.4 8.7e-05 22.6 13.4 1.7 1 0 0 1 1 1 1 EGF-like domain Filament PF00038.19 NM_172946.2_3 - 3.7e-31 108.7 23.9 3.7e-31 108.7 23.9 1.3 2 0 0 2 2 2 1 Intermediate filament protein BCAS2 PF05700.9 NM_172946.2_3 - 0.065 12.8 10.8 0.11 12.1 10.8 1.3 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) DUF1664 PF07889.10 NM_172946.2_3 - 0.08 12.8 9.3 0.051 13.4 3.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) GBP_C PF02841.12 NM_172946.2_3 - 0.29 10.4 15.1 0.53 9.5 15.1 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Allexi_40kDa PF05549.9 NM_172946.2_3 - 0.33 10.3 2.9 0.52 9.6 2.9 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein Spc7 PF08317.9 NM_172946.2_3 - 0.67 8.6 15.2 1.4 7.6 15.2 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.13 NM_172946.2_3 - 2.9 7.2 8.3 4.6 6.6 8.3 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.10 NM_172946.2_3 - 3.1 7.7 6.1 12 5.8 4.7 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Macoilin PF09726.7 NM_172946.2_3 - 3.5 5.9 17.5 2.5 6.4 16.1 1.3 1 1 0 1 1 1 0 Transmembrane protein IncA PF04156.12 NM_172946.2_3 - 7.8 6.1 24.8 23 4.6 24.5 1.8 1 1 0 1 1 1 0 IncA protein TF_Otx PF03529.11 NM_001286482.1_3 - 6.6e-32 109.7 14.6 6.6e-32 109.7 14.6 2.4 1 1 1 2 2 2 1 Otx1 transcription factor Homeobox PF00046.27 NM_001286482.1_3 - 1.7e-21 75.7 2.2 3.4e-21 74.7 2.2 1.5 1 0 0 1 1 1 1 Homeobox domain NUDE_C PF04880.11 NM_001286482.1_3 - 0.24 11.7 4.0 0.49 10.7 4.0 1.5 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DUF2464 PF10240.7 NM_028617.2_3 - 4.8e-62 209.6 0.0 5.6e-62 209.3 0.0 1.0 1 0 0 1 1 1 1 Multivesicular body subunit 12 PHD PF00628.27 NM_001291125.1_3 - 2.1e-07 30.6 6.4 4.2e-07 29.6 6.4 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.4 NM_001291125.1_3 - 2.4e-06 26.8 2.1 5.5e-06 25.7 2.1 1.6 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.20 NM_001291125.1_3 - 0.0068 16.1 0.5 0.0068 16.1 0.5 2.1 1 1 1 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Ribosomal_60s PF00428.17 NM_001291125.1_3 - 0.086 13.3 4.9 0.22 12.0 4.9 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein Nha1_C PF08619.8 NM_001291125.1_3 - 1.3 8.0 15.5 0.21 10.6 7.5 2.2 2 0 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus EBV-NA3 PF05009.10 NM_001291125.1_3 - 2.6 7.4 4.8 12 5.2 2.3 2.7 3 0 0 3 3 3 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Pox_Ag35 PF03286.12 NM_001291125.1_3 - 7.6 6.1 6.8 0.73 9.5 2.3 1.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein RRM_1 PF00076.20 NM_001290123.1_3 - 5.5e-34 115.7 0.1 3.4e-16 58.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001290123.1_3 - 9.7e-09 34.8 0.1 5.1e-05 22.7 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 NM_001290123.1_3 - 2.1e-07 30.6 3.2 5.6e-07 29.2 3.2 1.8 1 0 0 1 1 1 1 Zinc knuckle RRM_7 PF16367.3 NM_001290123.1_3 - 2.2e-05 24.3 0.0 0.023 14.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif RRM_occluded PF16842.3 NM_001290123.1_3 - 0.00044 19.9 0.0 0.032 13.9 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif zf-CCHC_3 PF13917.4 NM_001290123.1_3 - 0.0047 16.7 0.3 0.01 15.7 0.3 1.5 1 0 0 1 1 1 1 Zinc knuckle Calcipressin PF04847.10 NM_001290123.1_3 - 0.0078 15.8 0.1 4.2 6.9 0.0 2.3 1 1 1 2 2 2 2 Calcipressin DbpA PF03880.13 NM_001290123.1_3 - 0.033 14.0 0.1 11 6.0 0.0 2.3 2 0 0 2 2 2 0 DbpA RNA binding domain zf-CCHC_5 PF14787.4 NM_001290123.1_3 - 0.076 12.6 2.3 0.17 11.4 2.3 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger RNA_bind PF08675.9 NM_001290123.1_3 - 0.11 12.5 0.0 6.2 6.8 0.0 2.4 2 0 0 2 2 2 0 RNA binding domain zf-CCHC_2 PF13696.4 NM_001290123.1_3 - 0.51 10.1 7.4 0.18 11.5 3.8 2.1 2 0 0 2 2 2 0 Zinc knuckle Romo1 PF10247.7 NM_001164217.2_2 - 3.3e-25 88.0 20.9 4.5e-25 87.6 20.9 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.17 NM_001164217.2_2 - 0.0054 16.9 8.2 0.0073 16.5 8.2 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family GRIN_C PF15235.4 NM_183183.2_1 - 3.9e-47 159.7 0.5 1e-46 158.3 0.5 1.7 1 0 0 1 1 1 1 G protein-regulated inducer of neurite outgrowth C-terminus SHIPPO-rpt PF07004.10 NM_183182.3_2 - 0.056 14.2 13.1 11 7.0 0.0 5.3 5 0 0 5 5 5 0 Sperm-tail PG-rich repeat Thioredoxin_6 PF13848.4 NM_026983.2_2 - 6.4e-41 140.2 0.1 7.7e-41 139.9 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like domain BTB PF00651.29 NM_172765.3_3 - 1.5e-28 99.0 0.6 2.4e-28 98.5 0.6 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 NM_172765.3_3 - 5.4e-07 29.6 6.0 0.0002 21.5 1.2 3.3 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.24 NM_172765.3_3 - 7.3e-07 29.2 11.0 0.00074 19.7 0.4 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_172765.3_3 - 1.1e-05 25.7 9.4 0.012 16.3 0.3 3.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_172765.3_3 - 2.3e-05 24.1 6.3 0.0093 15.8 0.1 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_172765.3_3 - 0.00012 21.6 6.9 0.059 13.0 0.3 3.0 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-met PF12874.5 NM_172765.3_3 - 0.001 19.2 10.3 0.052 13.8 0.1 3.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type BEX PF04538.10 NM_025703.3_2 - 3.8e-23 82.3 7.0 5.2e-23 81.9 7.0 1.2 1 0 0 1 1 1 1 Brain expressed X-linked like family Yippee-Mis18 PF03226.12 NM_001005342.2_1 - 8.6e-13 48.3 0.3 8.6e-13 48.3 0.3 1.7 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly ATPgrasp_YheCD PF14398.4 NM_001005342.2_1 - 0.032 13.3 0.0 0.048 12.8 0.0 1.1 1 0 0 1 1 1 0 YheC/D like ATP-grasp Uteroglobin PF01099.15 NM_001310633.1_2 - 2.2e-20 72.5 0.5 2.8e-20 72.2 0.5 1.1 1 0 0 1 1 1 1 Uteroglobin family Chondroitinas_B PF14592.4 NM_001310633.1_2 - 0.051 12.3 0.0 0.051 12.3 0.0 1.1 1 0 0 1 1 1 0 Chondroitinase B 2-oxogl_dehyd_N PF16078.3 NM_001310633.1_2 - 0.19 11.2 0.2 0.4 10.2 0.2 1.5 1 1 0 1 1 1 0 2-oxoglutarate dehydrogenase N-terminus Las1 PF04031.11 NM_152822.3_1 - 4e-42 143.8 0.8 1.3e-41 142.1 0.7 1.9 2 0 0 2 2 2 1 Las1-like TPR_1 PF00515.26 NM_145436.2_1 - 3.2e-44 146.9 10.3 3e-09 36.2 0.2 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_145436.2_1 - 5.1e-31 106.6 23.6 7.3e-23 80.4 5.4 5.4 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.15 NM_145436.2_1 - 8.6e-30 100.3 11.7 1.5e-05 24.6 0.1 9.4 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.4 NM_145436.2_1 - 2.5e-23 80.1 12.4 0.00036 20.4 0.2 9.5 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_12 PF13424.4 NM_145436.2_1 - 4.3e-23 81.3 3.4 1.1e-05 25.5 0.0 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.4 NM_145436.2_1 - 7.1e-23 79.9 9.0 2.2e-06 27.1 0.1 8.1 4 1 5 9 9 9 5 TPR repeat TPR_17 PF13431.4 NM_145436.2_1 - 1.6e-19 68.7 6.1 0.0084 16.3 0.0 9.0 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.4 NM_145436.2_1 - 6.7e-18 65.0 0.0 7.9e-08 32.7 0.0 5.8 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_145436.2_1 - 9.3e-16 58.0 3.9 0.075 13.4 0.0 7.1 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.4 NM_145436.2_1 - 9.6e-14 50.8 0.0 0.016 15.9 0.0 7.7 4 1 4 8 8 7 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_145436.2_1 - 1.2e-10 41.2 0.0 0.00013 21.9 0.0 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_145436.2_1 - 8.9e-10 38.4 8.2 0.4 11.3 0.0 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_145436.2_1 - 4.2e-05 23.1 1.7 11 6.2 0.0 6.6 8 0 0 8 8 7 0 Tetratricopeptide repeat ChAPs PF09295.8 NM_145436.2_1 - 0.00057 18.9 0.9 0.16 10.8 0.0 2.3 1 1 1 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_15 PF13429.4 NM_145436.2_1 - 0.0022 17.1 0.1 2.6 7.0 0.0 3.9 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.4 NM_145436.2_1 - 0.029 14.1 0.0 4.1 7.3 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Cas_Cas02710 PF09670.8 NM_145436.2_1 - 0.17 10.5 0.0 0.35 9.5 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) DUF2225 PF09986.7 NM_145436.2_1 - 0.31 10.6 2.5 2.5 7.7 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Pou PF00157.15 NM_013633.3_3 - 9.7e-38 127.9 1.0 1.9e-37 127.0 1.0 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 NM_013633.3_3 - 2.1e-18 65.7 1.1 3.9e-18 64.9 1.1 1.4 1 0 0 1 1 1 1 Homeobox domain DUF521 PF04412.11 NM_013633.3_3 - 0.15 10.6 0.1 0.22 10.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Homeobox_KN PF05920.9 NM_013633.3_3 - 0.17 11.7 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 Homeobox KN domain Pkinase PF00069.23 NM_001316367.1_2 - 1.8e-59 201.2 0.0 2.3e-59 200.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001316367.1_2 - 2.8e-37 128.3 0.0 4.1e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001316367.1_2 - 5e-06 25.9 0.0 7.7e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.9 NM_001316367.1_2 - 0.0019 17.2 0.1 0.0029 16.6 0.1 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 RBP_receptor PF14752.4 NM_001162476.1_1 - 6.7e-245 814.2 4.2 7.9e-245 814.0 4.2 1.0 1 0 0 1 1 1 1 Retinol binding protein receptor UPF0560 PF10577.7 NM_001162476.1_1 - 1.1 7.5 2.8 1.7 6.9 2.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Vps8 PF12816.5 NM_001285894.1_1 - 4.4e-59 199.2 10.4 1.1e-57 194.7 1.1 2.7 2 1 0 2 2 2 2 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.18 NM_001285894.1_1 - 9.8e-07 28.6 9.7 0.0021 17.8 1.8 3.9 2 1 1 3 3 3 3 Region in Clathrin and VPS zf-RING_11 PF17123.3 NM_001285894.1_1 - 1.7e-05 24.3 2.7 5.4e-05 22.7 2.7 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.4 NM_001285894.1_1 - 0.0046 16.8 5.5 0.0046 16.8 5.5 2.3 2 0 0 2 2 2 1 RING-type zinc-finger PHD PF00628.27 NM_001285894.1_1 - 0.0094 15.7 8.6 0.024 14.4 8.6 1.8 1 0 0 1 1 1 1 PHD-finger zf-C3H2C3 PF17122.3 NM_001285894.1_1 - 0.022 14.7 3.7 0.024 14.6 1.2 2.3 2 0 0 2 2 2 0 Zinc-finger zf-RING_2 PF13639.4 NM_001285894.1_1 - 0.03 14.4 7.2 0.095 12.8 7.2 2.0 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.4 NM_001285894.1_1 - 0.039 13.8 8.1 0.11 12.3 8.1 1.9 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.23 NM_001285894.1_1 - 0.21 11.3 8.1 0.61 9.9 8.1 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) p450 PF00067.20 NM_010009.2_3 - 4.9e-95 318.8 0.0 5.7e-95 318.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SNF2_N PF00176.21 NM_023507.3_1 - 9.8e-54 182.2 0.8 1.5e-53 181.6 0.8 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 NM_023507.3_1 - 2.4e-21 76.0 0.0 1.5e-20 73.4 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_023507.3_1 - 1.7e-11 44.3 0.0 2.6e-10 40.4 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 NM_023507.3_1 - 1.1e-07 31.2 0.0 2.4e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.27 NM_023507.3_1 - 3.1e-07 30.2 0.0 8.6e-07 28.8 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.6 NM_023507.3_1 - 1.1e-05 24.7 0.3 4.9e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 SEC-C PF02810.13 NM_023507.3_1 - 0.36 10.7 9.1 0.76 9.6 9.1 1.6 1 0 0 1 1 1 0 SEC-C motif Myosin_head PF00063.19 NM_001290982.1_3 - 5.7e-265 880.6 5.4 7.6e-265 880.2 5.4 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 NM_001290982.1_3 - 1.3e-42 145.4 3.6 1.3e-42 145.4 3.6 2.6 3 0 0 3 3 3 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 NM_001290982.1_3 - 4.7e-10 38.2 18.5 0.00033 20.0 0.8 4.9 4 0 0 4 4 4 3 IQ calmodulin-binding motif AAA_16 PF13191.4 NM_001290982.1_3 - 0.013 15.8 0.0 0.041 14.1 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain Hpr_kinase_C PF07475.10 NM_001290982.1_3 - 0.033 13.6 0.9 2.9 7.3 0.0 2.6 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.4 NM_001290982.1_3 - 0.046 13.9 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain Peptidase_S8 PF00082.20 NM_153565.2_2 - 3.2e-22 79.0 0.0 5.9e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.14 NM_153565.2_2 - 0.0013 19.2 0.0 0.0021 18.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Ank_2 PF12796.5 NM_133971.3_3 - 9.8e-21 74.0 0.0 1.8e-11 44.3 0.0 2.4 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_133971.3_3 - 5.2e-20 71.4 0.3 6.7e-09 36.0 0.1 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_133971.3_3 - 3e-17 62.1 1.9 0.0036 17.6 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.4 NM_133971.3_3 - 2.3e-16 59.5 4.1 1.6e-07 31.3 0.1 4.4 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_133971.3_3 - 3e-13 48.5 0.7 0.075 13.5 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat APOC4 PF15119.4 NM_172644.4_1 - 0.077 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Apolipoprotein C4 tRNA-synt_2 PF00152.18 NM_172644.4_2 - 9.9e-94 313.8 0.0 1.4e-93 313.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) GAD PF02938.12 NM_172644.4_2 - 8.3e-12 45.1 0.0 1.3e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 GAD domain tRNA_anti-codon PF01336.23 NM_172644.4_2 - 1.1e-08 34.8 0.0 2.3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Glycos_transf_2 PF00535.24 NM_025442.3_1 - 6.6e-24 84.5 0.0 8.5e-24 84.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.4 NM_025442.3_1 - 1.3e-07 31.7 0.0 1.8e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.7 NM_025442.3_1 - 0.0028 17.1 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 BNIP2 PF12496.6 NM_134253.2_3 - 5.5e-37 127.1 0.0 8.1e-37 126.6 0.0 1.2 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 NM_134253.2_3 - 2.6e-32 111.7 0.2 3.5e-32 111.3 0.2 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 NM_134253.2_3 - 4e-09 36.2 0.0 6.8e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain SAM_1 PF00536.28 NM_029489.3_1 - 2.9e-13 49.9 0.0 4.7e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_029489.3_1 - 9.5e-09 35.1 0.0 1.9e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) L51_S25_CI-B8 PF05047.14 NM_053164.3_1 - 2.5e-10 40.0 0.1 4.5e-10 39.2 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Cofilin_ADF PF00241.18 NM_007687.5_2 - 1.9e-30 105.5 2.0 2.9e-30 104.9 2.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein TPT PF03151.14 NM_029875.2_2 - 2.8e-17 62.8 20.6 3.8e-17 62.4 20.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 NM_029875.2_2 - 0.00051 20.1 12.4 0.00051 20.1 12.4 2.3 2 0 0 2 2 2 2 EamA-like transporter family LIM PF00412.20 NM_133754.5_1 - 1.5e-32 111.4 34.7 3.3e-15 55.9 5.6 3.5 3 0 0 3 3 3 3 LIM domain WD40 PF00400.30 NM_027113.2_3 - 1.1e-57 190.6 18.3 5.1e-09 36.5 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_027113.2_3 - 2.2e-20 72.6 0.8 0.0017 18.5 0.0 6.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_027113.2_3 - 1e-09 38.4 0.1 3.8e-07 30.0 0.0 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 NM_027113.2_3 - 1.3e-08 33.8 9.0 0.019 13.5 0.0 5.6 4 2 2 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.3 NM_027113.2_3 - 1.7e-05 24.2 0.0 0.0021 17.3 0.0 2.8 1 1 1 2 2 2 1 WD40-like domain Frtz PF11768.6 NM_027113.2_3 - 0.0002 19.7 0.0 0.27 9.4 0.0 2.2 2 1 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.3 NM_027113.2_3 - 0.001 18.0 12.1 0.023 13.5 1.0 4.1 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein TACC PF05010.12 NM_199323.3_3 - 2.1e-80 269.2 33.7 2.8e-80 268.7 33.7 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) PI3K_P85_iSH2 PF16454.3 NM_199323.3_3 - 4.2 6.8 27.2 18 4.7 27.2 1.8 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain RRM_1 PF00076.20 NM_148917.2_1 - 6.1e-90 294.9 2.9 1.2e-22 79.3 0.3 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.16 NM_148917.2_1 - 2.2e-31 107.8 0.6 8.3e-31 105.9 0.4 2.1 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.4 NM_148917.2_1 - 1.8e-09 37.1 0.5 0.039 13.4 0.1 4.2 1 1 2 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 NM_148917.2_1 - 8.9e-08 31.9 0.1 2.3 8.1 0.0 4.5 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.3 NM_148917.2_1 - 2.5e-05 23.9 0.0 4.3 7.1 0.0 3.8 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_7 PF16367.3 NM_148917.2_1 - 6.6e-05 22.8 0.6 2.6 8.1 0.1 4.9 3 1 1 4 4 4 1 RNA recognition motif Limkain-b1 PF11608.6 NM_148917.2_1 - 0.00018 21.4 1.9 4.2 7.4 0.0 4.3 4 0 0 4 4 4 1 Limkain b1 RRM_3 PF08777.9 NM_148917.2_1 - 0.0019 18.1 6.6 1.4 8.9 0.9 3.7 4 0 0 4 4 4 2 RNA binding motif SET_assoc PF11767.6 NM_148917.2_1 - 0.0038 16.7 0.4 36 4.0 0.0 4.2 4 0 0 4 4 4 0 Histone lysine methyltransferase SET associated OB_RNB PF08206.9 NM_148917.2_1 - 0.015 14.9 2.7 3.6 7.2 0.1 3.3 3 0 0 3 3 3 0 Ribonuclease B OB domain ApbA_C PF08546.9 NM_148917.2_1 - 0.12 12.4 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal PHM7_cyt PF14703.4 NM_148917.2_1 - 0.22 11.6 0.7 26 4.9 0.0 3.8 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter HHV-5_US34A PF17087.3 NM_148917.2_1 - 1.5 8.9 4.0 19 5.4 1.1 2.4 2 0 0 2 2 2 0 Herpesvirus US34A protein family RRM_1 PF00076.20 NM_194055.3_3 - 5.5e-14 51.6 0.0 0.0014 18.2 0.0 3.7 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.22 NM_194055.3_3 - 0.012 16.1 0.0 0.02 15.3 0.0 1.3 1 0 0 1 1 1 0 Exonuclease Ribosomal_S3_C PF00189.18 NM_012052.2_2 - 1.8e-22 79.5 0.5 3.8e-22 78.5 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.15 NM_012052.2_2 - 8.4e-11 41.4 0.1 1.2e-10 40.9 0.1 1.3 1 0 0 1 1 1 1 KH domain 7tm_4 PF13853.4 NM_146914.2_1 - 5.9e-49 167.1 23.9 7.4e-49 166.8 23.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146914.2_1 - 3.7e-18 65.6 26.7 9.9e-18 64.2 26.7 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UPF0197 PF05251.10 NM_146914.2_1 - 0.54 10.2 5.8 1.3 9.0 0.4 3.2 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0197) LRR_9 PF14580.4 NM_001177877.1_1 - 1.2e-17 63.8 3.8 1.5e-17 63.5 1.9 1.8 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 NM_001177877.1_1 - 2e-11 43.8 14.3 0.00028 21.1 2.7 3.5 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_001177877.1_1 - 1.5e-05 24.6 18.6 0.00062 19.3 9.3 3.2 1 1 3 4 4 4 4 Leucine rich repeat LRR_1 PF00560.31 NM_001177877.1_1 - 3.9 8.2 15.4 26 5.7 0.5 5.3 5 2 0 5 5 5 0 Leucine Rich Repeat DUF3246 PF11596.6 NM_001141927.1_2 - 0.12 11.7 3.0 0.17 11.1 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Phospholamban PF04272.12 NM_001141927.1_3 - 7.1e-34 114.9 10.4 7.1e-34 114.9 10.4 2.6 2 0 0 2 2 2 1 Phospholamban Sarcolipin PF05366.9 NM_001141927.1_3 - 0.42 10.2 4.8 1.5 8.4 4.8 2.0 1 0 0 1 1 1 0 Sarcolipin Keratin_B2 PF01500.15 NM_001177537.2_3 - 1.6e-11 44.3 118.9 1.6e-05 24.8 59.6 2.9 2 1 0 2 2 2 2 Keratin, high sulfur B2 protein Keratin_B2_2 PF13885.4 NM_001177537.2_3 - 0.00035 20.3 108.9 0.0013 18.5 56.6 4.8 2 1 3 5 5 5 4 Keratin, high sulfur B2 protein Pkinase PF00069.23 NM_011946.3_1 - 4.4e-65 219.5 0.0 5.8e-65 219.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_011946.3_1 - 3.3e-38 131.3 0.0 4.5e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 NM_011946.3_1 - 1.5e-11 43.9 0.6 2.5e-11 43.2 0.6 1.3 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.4 NM_011946.3_1 - 0.00093 18.5 0.0 0.095 11.9 0.0 2.1 2 0 0 2 2 2 2 Kinase-like PDZ PF00595.22 NM_001159507.1_1 - 5.1e-86 283.0 0.5 1.4e-12 47.6 0.1 7.2 7 0 0 7 7 7 7 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001159507.1_1 - 8.6e-33 112.4 0.5 0.00066 19.8 0.0 7.3 7 0 0 7 7 7 7 PDZ domain GRASP55_65 PF04495.12 NM_001159507.1_1 - 0.017 15.3 0.0 6.6 6.9 0.0 4.1 3 2 2 5 5 5 0 GRASP55/65 PDZ-like domain Uteroglobin PF01099.15 NM_001099329.2_1 - 5.2e-18 64.9 0.9 6.5e-18 64.6 0.9 1.1 1 0 0 1 1 1 1 Uteroglobin family Cas9_REC PF16592.3 NM_001099329.2_1 - 0.067 11.8 0.5 0.087 11.4 0.5 1.0 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 p450 PF00067.20 NM_007815.3_1 - 1.7e-163 544.6 0.0 1.9e-163 544.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAM53 PF15242.4 NM_178390.3_3 - 1.8e-109 366.2 16.0 2.5e-109 365.7 16.0 1.2 1 0 0 1 1 1 1 Family of FAM53 NHS PF15273.4 NM_001290526.1_3 - 3.6e-214 713.4 49.7 3.6e-214 713.4 49.7 2.4 2 1 0 2 2 2 1 NHS-like 7tm_4 PF13853.4 NM_146551.1_1 - 4.4e-49 167.5 22.3 6.1e-49 167.1 22.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146551.1_1 - 1.7e-23 83.1 24.9 3.9e-23 81.9 24.9 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146551.1_1 - 0.1 11.8 30.0 1.2 8.3 29.9 2.2 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4880 PF16220.3 NM_001163762.1_3 - 0.037 13.8 2.5 0.097 12.4 2.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4880) LRR_8 PF13855.4 NM_173418.3_3 - 7.3e-23 80.0 7.3 1.1e-12 47.4 1.4 2.6 1 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 NM_173418.3_3 - 1.6e-13 50.4 4.1 4.4e-06 26.8 0.9 2.9 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) Ig_3 PF13927.4 NM_173418.3_3 - 3.1e-13 50.0 0.0 5.6e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_173418.3_3 - 1.5e-10 40.9 0.0 2.5e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 NM_173418.3_3 - 5.3e-09 36.0 0.0 1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_173418.3_3 - 1.6e-05 25.1 0.0 3.6e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRRNT PF01462.16 NM_173418.3_3 - 0.015 14.8 1.4 0.054 13.0 0.9 2.3 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 NM_173418.3_3 - 0.1 13.0 8.8 21 6.0 0.0 5.7 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.4 NM_173418.3_3 - 0.24 11.4 6.4 12 6.2 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich repeat SelP_N PF04592.12 NM_175403.3_1 - 0.5 9.6 9.9 0.77 9.0 9.9 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Malectin PF11721.6 NM_175403.3_2 - 2e-43 148.2 0.0 3e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 Di-glucose binding within endoplasmic reticulum LysM PF01476.18 NM_153121.2_1 - 7.6e-07 29.0 0.0 1.3e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 LysM domain SRRM_C PF15230.4 NM_026886.3_3 - 5.2e-24 84.5 26.3 5.2e-24 84.5 26.3 8.4 3 3 4 7 7 7 1 Serine/arginine repetitive matrix protein C-terminus PDEase_I PF00233.17 NM_001177982.1_3 - 1.9e-93 312.5 4.8 1.9e-93 312.5 4.8 1.6 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GATA PF00320.25 NM_001310481.1_3 - 2.7e-12 45.9 5.8 1.1e-11 44.0 5.8 2.2 1 0 0 1 1 1 1 GATA zinc finger TMEM232 PF15877.3 NM_001289486.1_2 - 3.1e-228 758.2 7.3 3.1e-228 758.2 7.3 1.8 2 0 0 2 2 2 1 Transmembrane protein family 232 MRC1 PF09444.8 NM_001289486.1_2 - 1.7 9.0 11.0 0.53 10.7 7.9 1.6 2 0 0 2 2 2 0 MRC1-like domain DUF4163 PF13739.4 NM_001289486.1_2 - 3.2 8.7 8.0 1.4 9.8 4.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4163) Reprolysin PF01421.17 NM_001290465.1_2 - 1.5e-12 47.7 0.0 3.2e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease TSP_1 PF00090.17 NM_001290465.1_2 - 1.2e-11 44.5 23.5 1.6e-10 40.9 8.5 8.4 8 1 0 8 8 8 4 Thrombospondin type 1 domain Reprolysin_4 PF13583.4 NM_001290465.1_2 - 4.9e-10 39.3 0.0 8.2e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.4 NM_001290465.1_2 - 8.4e-10 39.1 0.0 1.7e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 NM_001290465.1_2 - 8.6e-06 25.9 0.8 2.1e-05 24.7 0.8 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.4 NM_001290465.1_2 - 0.003 17.4 0.2 0.003 17.4 0.2 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 NM_001290465.1_2 - 0.003 17.3 0.0 0.0052 16.5 0.0 1.3 1 0 0 1 1 1 1 Matrixin Sensor PF13796.4 NM_001290465.1_2 - 0.059 13.3 0.1 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 Putative sensor 7tm_4 PF13853.4 NM_001011808.1_1 - 1.4e-44 152.7 17.6 1.7e-44 152.5 17.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011808.1_1 - 5.9e-19 68.2 18.7 1.2e-18 67.2 18.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PGM_PMM_I PF02878.14 NM_001163746.1_2 - 1e-16 60.7 0.0 3.7e-07 29.8 0.0 2.3 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.18 NM_001163746.1_2 - 6.4e-09 35.7 0.1 1.3e-08 34.7 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.14 NM_001163746.1_2 - 0.002 18.2 0.1 0.0035 17.4 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III RhoGAP PF00620.25 NM_198101.1_2 - 2.9e-47 160.2 0.0 5.8e-47 159.2 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 NM_198101.1_2 - 1.6e-05 24.5 6.9 4.2e-05 23.2 6.9 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Serpin PF00079.18 NM_009250.2_3 - 1.2e-110 370.2 1.6 1.4e-110 370.0 1.6 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-RING_2 PF13639.4 NM_011634.3_2 - 3.7e-09 36.6 7.9 3.7e-09 36.6 7.9 2.6 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.5 NM_011634.3_2 - 6.4e-07 29.4 5.6 2.2e-06 27.7 5.6 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 NM_011634.3_2 - 6.1e-06 25.8 7.5 6.1e-06 25.8 7.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_011634.3_2 - 2.3e-05 24.2 4.9 2.3e-05 24.2 4.9 2.5 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_011634.3_2 - 3.7e-05 23.4 6.2 3.7e-05 23.4 6.2 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_011634.3_2 - 7.7e-05 22.6 8.3 0.00018 21.4 5.0 2.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 NM_011634.3_2 - 0.00015 21.4 3.8 0.00015 21.4 3.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_011634.3_2 - 0.00031 20.5 5.9 0.00031 20.5 5.9 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.3 NM_011634.3_2 - 0.00047 19.7 7.5 0.0013 18.3 7.5 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.5 NM_011634.3_2 - 0.00071 19.5 2.4 0.00071 19.5 2.4 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger BRE1 PF08647.9 NM_011634.3_2 - 0.0011 18.8 9.8 0.0011 18.8 9.8 3.3 2 1 1 3 3 2 1 BRE1 E3 ubiquitin ligase SNARE PF05739.17 NM_011634.3_2 - 0.026 14.4 0.3 0.2 11.5 0.1 2.4 2 0 0 2 2 2 0 SNARE domain HIP1_clath_bdg PF16515.3 NM_011634.3_2 - 0.035 14.6 34.4 0.082 13.4 10.1 3.6 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FANCL_C PF11793.6 NM_011634.3_2 - 0.038 14.0 2.6 0.11 12.6 2.6 1.8 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.9 NM_011634.3_2 - 0.058 13.6 6.5 0.23 11.6 6.5 2.1 1 0 0 1 1 1 0 RING-like domain GAS PF13851.4 NM_011634.3_2 - 0.069 12.4 37.1 2.2 7.4 25.1 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.9 NM_011634.3_2 - 0.07 11.9 33.8 0.036 12.8 12.2 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Zn_ribbon_17 PF17120.3 NM_011634.3_2 - 0.25 10.9 10.4 0.012 15.1 4.2 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type CENP-F_leu_zip PF10473.7 NM_011634.3_2 - 0.26 11.2 38.1 1.7 8.6 12.1 3.2 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RINGv PF12906.5 NM_011634.3_2 - 0.34 10.9 5.8 1.3 9.0 5.8 2.1 1 0 0 1 1 1 0 RING-variant domain Fez1 PF06818.13 NM_011634.3_2 - 0.41 10.9 31.0 1.1 9.5 16.6 2.2 1 1 1 2 2 2 0 Fez1 WEMBL PF05701.9 NM_011634.3_2 - 0.77 8.2 30.4 4.1 5.8 30.1 1.9 1 1 0 1 1 1 0 Weak chloroplast movement under blue light Laminin_II PF06009.10 NM_011634.3_2 - 0.92 9.4 19.9 2 8.3 2.6 2.6 2 0 0 2 2 2 0 Laminin Domain II zf-RING_4 PF14570.4 NM_011634.3_2 - 0.93 9.1 4.2 2.4 7.8 4.2 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Seryl_tRNA_N PF02403.20 NM_011634.3_2 - 2.3 8.3 27.3 1.6 8.9 13.9 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF724 PF05266.12 NM_011634.3_2 - 2.7 7.6 20.3 2.5 7.8 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF724) DUF3450 PF11932.6 NM_011634.3_2 - 3 6.9 28.1 1.7 7.8 6.5 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) TRAF_BIRC3_bd PF16673.3 NM_011634.3_2 - 4.2 7.1 12.1 2 8.1 0.5 3.0 2 1 1 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain DegS PF05384.9 NM_011634.3_2 - 4.2 6.7 24.9 8.8 5.7 13.1 3.4 1 1 1 2 2 2 0 Sensor protein DegS DUF1664 PF07889.10 NM_011634.3_2 - 4.6 7.1 21.2 1.4 8.8 4.1 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) MscS_porin PF12795.5 NM_011634.3_2 - 5.4 6.4 32.8 1.8 7.9 8.7 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain ATPase PF06745.11 NM_011634.3_2 - 6.2 5.9 6.6 28 3.8 6.5 1.9 1 1 0 1 1 1 0 KaiC DUF745 PF05335.11 NM_011634.3_2 - 6.6 6.3 22.9 4.8 6.8 1.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF745) TEX13 PF15186.4 NM_011634.3_2 - 6.9 6.2 21.8 0.53 9.8 3.6 2.6 2 1 0 2 2 2 0 Testis-expressed sequence 13 protein family DUF812 PF05667.9 NM_011634.3_2 - 8.4 5.0 29.0 12 4.5 29.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Reo_sigmaC PF04582.10 NM_011634.3_2 - 8.8 5.5 11.3 9.3 5.4 3.0 2.1 1 1 0 2 2 2 0 Reovirus sigma C capsid protein Sulfotransfer_1 PF00685.25 NM_001253355.1_2 - 2.3e-34 118.9 0.2 3.3e-34 118.5 0.2 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_001253355.1_2 - 4.3e-09 37.0 0.0 8.4e-05 22.9 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family VWD PF00094.23 NM_009347.3_1 - 5.9e-149 491.2 1.8 1.9e-42 145.1 0.0 4.9 5 0 0 5 5 5 4 von Willebrand factor type D domain C8 PF08742.9 NM_009347.3_1 - 3.1e-56 187.5 57.4 2e-16 60.0 4.4 8.0 6 1 1 7 7 7 4 C8 domain Zona_pellucida PF00100.21 NM_009347.3_1 - 5.6e-47 160.5 5.7 1.3e-46 159.3 5.7 1.7 1 0 0 1 1 1 1 Zona pellucida-like domain NIDO PF06119.12 NM_009347.3_1 - 6.2e-27 94.3 0.5 1.5e-26 93.1 0.5 1.7 1 0 0 1 1 1 1 Nidogen-like TIL PF01826.15 NM_009347.3_1 - 7.1e-27 93.3 70.7 9.9e-12 44.8 19.0 12.4 13 1 0 13 13 13 3 Trypsin Inhibitor like cysteine rich domain TILa PF12714.5 NM_009347.3_1 - 9.4e-17 60.6 62.0 1.4e-08 34.4 8.6 11.0 8 3 3 11 11 11 4 TILa domain FXa_inhibition PF14670.4 NM_009347.3_1 - 3.8e-05 23.8 9.6 3.8e-05 23.8 9.6 10.0 11 4 2 13 13 13 1 Coagulation Factor Xa inhibitory site T-box PF00907.20 NM_011533.2_2 - 1.5e-78 263.1 0.0 2e-78 262.7 0.0 1.1 1 0 0 1 1 1 1 T-box Antimicrobial_5 PF08026.9 NM_011533.2_2 - 0.074 12.9 4.2 9.3 6.2 0.0 4.4 4 0 0 4 4 4 0 Bee antimicrobial peptide DUF3446 PF11928.6 NM_011533.2_2 - 8.1 6.7 8.5 1 9.5 1.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3446) Lipase PF00151.17 NM_018874.2_1 - 2.5e-154 513.5 0.0 3e-154 513.2 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 NM_018874.2_1 - 2.2e-14 53.9 0.4 4.5e-14 52.9 0.1 1.7 2 0 0 2 2 2 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 NM_018874.2_1 - 3e-05 24.6 0.0 5.2e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.11 NM_018874.2_1 - 0.02 14.6 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold LIDHydrolase PF10230.7 NM_018874.2_1 - 0.02 14.3 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF900 PF05990.10 NM_018874.2_1 - 0.022 14.2 0.1 0.033 13.6 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF676 PF05057.12 NM_018874.2_1 - 0.027 13.8 0.1 0.045 13.1 0.1 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Lipase_2 PF01674.16 NM_018874.2_1 - 0.051 13.0 0.2 0.084 12.3 0.2 1.2 1 0 0 1 1 1 0 Lipase (class 2) Brr6_like_C_C PF10104.7 NM_018874.2_1 - 0.068 12.8 0.1 0.068 12.8 0.1 1.9 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain Lipase_3 PF01764.23 NM_018874.2_1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Hydrolase_4 PF12146.6 NM_018874.2_1 - 0.18 10.9 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 SAP PF02037.25 NM_178089.2_1 - 1.3e-09 37.4 3.3 1.3e-09 37.4 3.3 1.9 2 0 0 2 2 2 1 SAP domain SPRY PF00622.26 NM_178089.2_1 - 3.1e-08 33.6 0.0 5.7e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 SPRY domain Telomere_Sde2_2 PF13297.4 NM_178089.2_1 - 0.21 11.1 3.0 0.31 10.6 2.1 1.7 2 0 0 2 2 2 0 Telomere stability C-terminal Rox3 PF08633.8 NM_178089.2_1 - 0.62 10.2 6.4 0.15 12.2 2.0 1.9 2 0 0 2 2 2 0 Rox3 mediator complex subunit Tissue_fac PF01108.15 NM_008338.3_1 - 1.7e-26 92.0 0.0 2.9e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.8 NM_008338.3_1 - 2.5e-08 34.0 0.1 4.2e-08 33.3 0.1 1.4 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III DUF2648 PF10855.6 NM_008338.3_1 - 0.075 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2648) Phe_ZIP PF08916.9 NM_008507.4_2 - 2.3e-17 63.3 4.3 4.2e-17 62.5 4.3 1.5 1 0 0 1 1 1 1 Phenylalanine zipper SH2 PF00017.22 NM_008507.4_2 - 1.1e-13 50.9 0.0 1.8e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 NM_008507.4_2 - 5.6e-05 23.5 0.0 0.00013 22.3 0.0 1.5 1 0 0 1 1 1 1 PH domain Rib_recp_KP_reg PF05104.10 NM_024281.2_2 - 5.1e-27 95.7 33.7 5.1e-27 95.7 33.7 9.4 4 3 4 9 9 9 1 Ribosome receptor lysine/proline rich region ABC_export PF16962.3 NM_024281.2_2 - 0.18 10.1 0.2 0.52 8.6 0.2 1.7 1 0 0 1 1 1 0 Putative ABC exporter IncA PF04156.12 NM_024281.2_2 - 4.1 7.0 163.8 0.11 12.2 18.4 8.5 3 2 5 8 8 8 0 IncA protein Pkinase PF00069.23 NM_011785.3_2 - 1.4e-76 257.2 0.0 2.2e-76 256.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_011785.3_2 - 1.1e-35 123.1 0.0 2.5e-35 121.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PH PF00169.27 NM_011785.3_2 - 2.4e-14 53.6 0.1 6.9e-14 52.1 0.1 1.9 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.22 NM_011785.3_2 - 1.7e-08 34.9 3.7 4e-08 33.7 3.7 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_011785.3_2 - 1e-07 31.4 0.0 1.9e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like ArfGap PF01412.16 NM_010472.3_3 - 7.4e-28 96.8 0.4 2e-27 95.4 0.0 1.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf V-set PF07686.15 NM_001160711.1_3 - 1.5e-11 44.3 0.0 3e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 NM_001160711.1_3 - 0.0031 17.5 0.0 0.0086 16.1 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_001160711.1_3 - 0.0032 17.9 0.0 0.0085 16.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Herpes_gE PF02480.14 NM_001160711.1_3 - 0.062 11.9 0.0 0.096 11.3 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E I-set PF07679.14 NM_001160711.1_3 - 0.17 11.8 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain Soyouz_module PF14313.4 NM_001160711.1_3 - 6.7 6.4 5.6 7.6 6.3 0.3 3.0 3 0 0 3 3 3 0 N-terminal region of Paramyxovirinae phosphoprotein (P) Bax1-I PF01027.18 NM_027154.5_3 - 4.1e-31 108.3 31.6 5.2e-31 108.0 31.6 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.5 NM_027154.5_3 - 2.5 7.5 19.3 3.8 6.9 19.3 1.2 1 0 0 1 1 1 0 Bax inhibitor 1 like Ion_trans PF00520.29 NM_001294162.1_2 - 1.6e-35 122.4 3.1 2.2e-35 121.9 3.1 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.27 NM_001294162.1_2 - 7.4e-12 45.0 0.0 1.7e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 NM_001294162.1_2 - 1.7e-11 43.8 0.3 1.7e-11 43.8 0.3 2.1 2 0 0 2 2 2 1 Ion channel Pkinase PF00069.23 NM_001045964.1_1 - 1.5e-61 207.9 1.7 7.4e-61 205.7 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain CNH PF00780.20 NM_001045964.1_1 - 7.4e-58 196.2 0.0 1.1e-57 195.6 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 NM_001045964.1_1 - 1.2e-45 155.7 0.5 1.8e-45 155.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PMP22_Claudin PF00822.18 NM_001165926.1_3 - 2.3e-28 99.0 9.3 3.1e-28 98.6 9.3 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_001165926.1_3 - 9.4e-05 22.1 16.0 0.00021 21.0 12.9 2.2 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.9 NM_001165926.1_3 - 0.17 11.6 9.5 0.19 11.4 8.3 1.8 1 1 1 2 2 2 0 Amastin surface glycoprotein DGF-1_C PF11040.6 NM_001165926.1_3 - 0.18 11.7 1.5 0.37 10.7 1.5 1.4 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus PARP PF00644.18 NM_181402.3_3 - 1.3e-47 162.0 0.1 1.9e-47 161.5 0.1 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.18 NM_181402.3_3 - 8.3e-15 55.0 0.1 1.5e-14 54.1 0.1 1.5 1 0 0 1 1 1 1 WWE domain zf-C4 PF00105.16 NM_001313983.1_3 - 2.7e-29 101.3 18.1 5.6e-29 100.3 18.1 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001313983.1_3 - 1.6e-17 63.7 0.0 3.5e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-3CxxC PF13695.4 NM_153100.2_1 - 3.5e-26 91.4 1.5 1.2e-25 89.7 1.5 2.0 1 0 0 1 1 1 1 Zinc-binding domain ATP-synt_E PF05680.10 NM_007507.2_3 - 1.4e-17 63.6 0.1 1.4e-17 63.6 0.1 2.1 2 0 0 2 2 2 1 ATP synthase E chain DUF4604 PF15377.4 NM_007507.2_3 - 0.077 13.3 17.1 0.088 13.1 17.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Hormone_1 PF00103.18 NM_028477.2_2 - 1.5e-57 194.7 5.1 2.9e-57 193.8 5.1 1.4 1 1 0 1 1 1 1 Somatotropin hormone family Galactosyl_T PF01762.19 NM_001036740.2_3 - 7.3e-30 104.1 0.0 9.2e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase DAGK_acc PF00609.17 NM_177646.3_3 - 8.9e-51 172.3 0.0 1.5e-50 171.5 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 NM_177646.3_3 - 5.6e-27 93.7 0.0 1.2e-26 92.6 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain SAM_2 PF07647.15 NM_177646.3_3 - 2.4e-19 69.1 0.4 6.3e-19 67.7 0.1 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) C1_1 PF00130.20 NM_177646.3_3 - 5.2e-18 64.5 25.1 2.7e-09 36.6 5.6 3.2 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) SAM_1 PF00536.28 NM_177646.3_3 - 4.8e-17 62.0 1.8 7e-17 61.5 0.3 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.27 NM_177646.3_3 - 7e-12 45.7 0.6 1.5e-11 44.6 0.1 1.9 2 0 0 2 2 2 1 PH domain PH_3 PF14593.4 NM_177646.3_3 - 9.1e-07 28.8 0.5 2e-06 27.7 0.5 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 NM_177646.3_3 - 0.0018 18.4 0.1 0.0039 17.3 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain C1_2 PF03107.14 NM_177646.3_3 - 0.0057 16.8 16.2 0.038 14.2 5.7 2.9 2 0 0 2 2 2 2 C1 domain Mcp5_PH PF12814.5 NM_177646.3_3 - 0.037 14.0 0.1 0.088 12.8 0.1 1.6 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology PH_11 PF15413.4 NM_177646.3_3 - 0.069 13.4 0.8 0.58 10.5 0.8 2.7 1 1 0 1 1 1 0 Pleckstrin homology domain Rsc14 PF08586.8 NM_177646.3_3 - 0.11 13.2 0.0 0.42 11.3 0.0 2.0 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit AAA PF00004.27 NM_145488.1_2 - 1.7e-64 216.0 0.0 2.4e-46 157.3 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 NM_145488.1_2 - 3.2e-12 47.0 2.1 4.8e-05 23.7 0.2 3.7 2 1 1 3 3 3 2 AAA ATPase domain AAA_11 PF13086.4 NM_145488.1_2 - 4.6e-08 33.0 0.2 0.00036 20.2 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.4 NM_145488.1_2 - 1.1e-07 32.0 0.0 0.01 15.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.4 NM_145488.1_2 - 3.6e-07 30.4 2.6 0.015 15.5 0.1 3.6 3 2 1 4 4 4 2 AAA domain AAA_5 PF07728.12 NM_145488.1_2 - 4.4e-07 29.8 0.4 0.066 13.1 0.0 3.4 3 1 0 3 3 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.10 NM_145488.1_2 - 4.4e-06 26.0 0.1 0.0055 15.9 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus TsaE PF02367.15 NM_145488.1_2 - 6.3e-06 26.1 0.7 0.12 12.2 0.0 2.6 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.10 NM_145488.1_2 - 6.7e-06 26.0 5.6 0.81 9.5 0.4 3.6 2 1 1 3 3 3 3 NACHT domain AAA_25 PF13481.4 NM_145488.1_2 - 1.3e-05 24.7 0.1 0.041 13.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.11 NM_145488.1_2 - 3.3e-05 22.9 0.1 0.03 13.1 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus AAA_19 PF13245.4 NM_145488.1_2 - 3.4e-05 24.1 0.0 0.057 13.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.4 NM_145488.1_2 - 5.5e-05 22.8 0.3 0.063 12.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.15 NM_145488.1_2 - 0.00011 21.9 0.0 0.039 13.6 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.20 NM_145488.1_2 - 0.00013 22.2 0.0 0.15 12.4 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.4 NM_145488.1_2 - 0.00015 22.2 0.1 0.89 9.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.19 NM_145488.1_2 - 0.00089 18.6 4.6 0.056 12.7 0.1 2.7 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI AAA_17 PF13207.4 NM_145488.1_2 - 0.0017 18.6 0.2 2.5 8.4 0.1 2.5 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.8 NM_145488.1_2 - 0.002 18.0 0.0 0.0048 16.7 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_3 PF07726.9 NM_145488.1_2 - 0.0034 17.1 0.0 1 9.1 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.13 NM_145488.1_2 - 0.0034 17.2 0.2 1.2 8.9 0.0 2.4 2 0 0 2 2 2 1 NTPase Viral_helicase1 PF01443.16 NM_145488.1_2 - 0.0041 16.8 0.0 3 7.4 0.1 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.4 NM_145488.1_2 - 0.0051 16.9 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.4 NM_145488.1_2 - 0.0076 15.8 1.3 0.75 9.4 0.2 2.7 2 1 0 2 2 2 1 P-loop containing region of AAA domain AAA_24 PF13479.4 NM_145488.1_2 - 0.0086 15.7 0.1 5.8 6.5 0.1 2.8 3 0 0 3 3 3 0 AAA domain DUF2075 PF09848.7 NM_145488.1_2 - 0.0088 15.2 0.0 0.54 9.3 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) DUF815 PF05673.11 NM_145488.1_2 - 0.042 12.9 0.0 1.7 7.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.24 NM_145488.1_2 - 0.046 13.3 0.0 2.8 7.5 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_2 PF07724.12 NM_145488.1_2 - 0.046 13.7 0.0 0.24 11.4 0.0 2.0 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) PhoH PF02562.14 NM_145488.1_2 - 0.054 12.8 1.0 0.72 9.1 0.1 2.2 2 0 0 2 2 2 0 PhoH-like protein ATPase PF06745.11 NM_145488.1_2 - 0.058 12.6 0.2 2.7 7.1 0.0 2.1 2 0 0 2 2 2 0 KaiC NB-ARC PF00931.20 NM_145488.1_2 - 0.058 12.3 0.4 2.7 6.8 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain T2SSE PF00437.18 NM_145488.1_2 - 0.1 11.5 2.4 5.5 5.8 0.5 2.7 3 0 0 3 3 3 0 Type II/IV secretion system protein DEAD PF00270.27 NM_145488.1_2 - 0.16 11.6 0.4 5.7 6.5 0.3 2.8 2 1 0 2 2 2 0 DEAD/DEAH box helicase Cytidylate_kin PF02224.16 NM_145488.1_2 - 0.16 11.5 0.4 6.5 6.3 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase cobW PF02492.17 NM_145488.1_2 - 0.53 9.7 2.2 3 7.3 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.25 NM_145488.1_2 - 1.1 9.6 3.0 24 5.3 0.2 2.5 2 0 0 2 2 2 0 ABC transporter Pkinase PF00069.23 NM_001009930.3_3 - 2e-71 240.3 0.0 2.9e-71 239.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001009930.3_3 - 4.3e-39 134.2 0.0 5.6e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_001009930.3_3 - 0.0012 18.7 2.1 0.003 17.4 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_001009930.3_3 - 0.018 14.2 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.18 NM_001009930.3_3 - 0.055 12.9 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.12 NM_001009930.3_3 - 0.074 12.3 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family V1R PF03402.12 NM_134237.1_1 - 1.5e-36 126.3 7.0 2.2e-36 125.7 7.0 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_134237.1_1 - 9.4e-05 21.5 18.8 0.00031 19.8 18.8 1.7 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_134237.1_1 - 0.1 11.6 4.4 0.034 13.3 1.7 1.6 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) Ephrin_lbd PF01404.17 NM_001122889.1_3 - 6e-71 238.0 0.1 1.2e-70 237.1 0.1 1.5 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain fn3 PF00041.19 NM_001122889.1_3 - 3.1e-31 107.4 2.7 6e-16 58.4 1.4 2.7 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_001122889.1_3 - 0.0002 21.7 2.6 0.00056 20.3 0.7 2.4 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.11 NM_001122889.1_3 - 0.00044 19.8 9.0 0.00044 19.8 9.0 3.1 2 1 1 3 3 3 1 Putative ephrin-receptor like Tissue_fac PF01108.15 NM_001122889.1_3 - 0.0023 17.6 0.3 0.14 11.8 0.0 2.6 2 0 0 2 2 2 1 Tissue factor fn3_2 PF16893.3 NM_001122889.1_3 - 0.0042 17.1 1.1 1.6 8.8 0.0 2.5 2 0 0 2 2 2 2 Fibronectin type III domain DUF2318 PF10080.7 NM_001122889.1_3 - 0.0053 16.7 1.7 0.017 15.1 1.7 1.8 1 0 0 1 1 1 1 Predicted membrane protein (DUF2318) Y_Y_Y PF07495.11 NM_001122889.1_3 - 0.018 14.8 0.4 0.36 10.7 0.6 2.5 2 0 0 2 2 2 0 Y_Y_Y domain Interfer-bind PF09294.8 NM_001122889.1_3 - 0.049 13.8 0.2 0.28 11.4 0.1 2.2 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III SusE PF14292.4 NM_001122889.1_3 - 0.12 12.6 0.1 22 5.3 0.1 2.4 2 0 0 2 2 2 0 SusE outer membrane protein EGF_MSP1_1 PF12946.5 NM_001122889.1_3 - 3.2 7.7 9.2 0.38 10.7 1.7 2.7 2 0 0 2 2 2 0 MSP1 EGF domain 1 Cadherin PF00028.15 NM_130878.2_1 - 4e-73 241.8 0.2 7.6e-15 55.0 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Y_Y_Y PF07495.11 NM_130878.2_1 - 0.068 13.0 0.0 59 3.6 0.0 4.0 4 0 0 4 4 4 0 Y_Y_Y domain PMG PF05287.10 NM_183189.1_2 - 8.3e-56 188.7 56.5 1e-55 188.5 56.5 1.1 1 0 0 1 1 1 1 PMG protein Mitoc_L55 PF09776.7 NM_001302334.1_2 - 2.1e-56 188.5 0.7 2.9e-56 188.1 0.7 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 Hydrolase PF00702.24 NM_001271963.1_2 - 1.3e-06 28.7 0.0 1.7e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ion_trans PF00520.29 NM_175130.4_2 - 3.2e-13 49.4 13.2 5.2e-12 45.4 13.2 2.2 1 1 0 1 1 1 1 Ion transport protein zf-H2C2_2 PF13465.4 NM_172919.2_3 - 1.2e-86 281.5 99.2 3e-11 43.1 1.1 14.8 15 0 0 15 15 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_172919.2_3 - 1.2e-65 214.3 108.1 8.7e-07 28.9 0.5 14.5 14 0 0 14 14 14 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_172919.2_3 - 2.3e-52 170.9 99.5 0.00018 21.9 1.2 14.7 14 0 0 14 14 14 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_172919.2_3 - 2.9e-33 113.1 77.4 0.00024 20.9 1.0 13.9 13 0 0 13 13 13 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_172919.2_3 - 2.5e-23 81.7 60.0 0.09 13.0 0.1 14.5 14 0 0 14 14 14 11 Zinc-finger double-stranded RNA-binding KRAB PF01352.25 NM_172919.2_3 - 2.6e-23 81.3 0.4 4.5e-23 80.5 0.4 1.4 1 0 0 1 1 1 1 KRAB box XPA_N PF01286.16 NM_172919.2_3 - 1.9e-17 62.9 50.2 0.07 13.0 0.1 13.6 13 0 0 13 13 13 6 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_172919.2_3 - 5.2e-09 36.6 44.3 0.088 13.4 0.3 7.5 3 3 6 9 9 9 7 zinc-ribbon family zf-H2C2_5 PF13909.4 NM_172919.2_3 - 3.8e-06 26.4 73.6 0.078 12.6 0.1 13.9 15 0 0 15 15 14 5 C2H2-type zinc-finger domain Zn-ribbon_8 PF09723.8 NM_172919.2_3 - 1.1e-05 25.3 64.5 0.1 12.6 2.5 9.7 4 3 6 11 11 10 5 Zinc ribbon domain C1_1 PF00130.20 NM_172919.2_3 - 2.1e-05 24.1 35.3 0.37 10.6 0.1 9.0 2 2 6 9 9 9 3 Phorbol esters/diacylglycerol binding domain (C1 domain) GAGA PF09237.9 NM_172919.2_3 - 0.0018 17.9 18.8 1.1 9.0 0.0 6.9 5 2 1 7 7 6 1 GAGA factor zf-C2H2_11 PF16622.3 NM_172919.2_3 - 0.0071 15.9 0.2 0.0071 15.9 0.2 13.0 13 0 0 13 13 13 3 zinc-finger C2H2-type zf-BED PF02892.13 NM_172919.2_3 - 0.026 14.4 94.5 0.16 11.9 0.6 13.4 6 2 7 13 13 13 0 BED zinc finger HypA PF01155.17 NM_172919.2_3 - 0.087 12.7 39.1 2.4 8.1 3.1 7.5 2 1 5 7 7 7 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-trcl PF13451.4 NM_172919.2_3 - 0.57 10.0 54.8 5.1 6.9 4.3 11.9 11 2 0 11 11 11 0 Probable zinc-ribbon domain zf-C2HE PF16278.3 NM_172919.2_3 - 2.4 8.6 65.8 1.8 8.9 0.1 12.9 2 1 10 12 12 12 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.5 NM_172919.2_3 - 3.6 7.8 51.8 1.3 9.2 1.5 9.4 1 1 6 8 8 8 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.4 NM_172919.2_3 - 3.8 7.4 45.9 2.2 8.2 0.3 9.7 10 0 0 10 10 9 0 zinc-finger of a C2HC-type Tubulin PF00091.23 NM_011655.5_3 - 1.4e-68 230.8 0.0 2e-68 230.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_011655.5_3 - 8.7e-42 142.2 0.1 1.3e-41 141.6 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 NM_011655.5_3 - 2.7e-05 24.3 0.0 6.7e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 NM_011655.5_3 - 0.019 14.6 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 NM_011655.5_3 - 0.043 12.9 0.0 0.074 12.1 0.0 1.3 1 0 0 1 1 1 0 Tubulin like RRM_1 PF00076.20 NM_001270512.1_2 - 6.3e-19 67.4 0.1 1.1e-18 66.6 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 NM_001270512.1_2 - 0.0011 18.9 9.8 0.0011 18.9 9.8 4.9 5 1 1 6 6 6 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 NM_001270512.1_2 - 0.0025 17.8 0.0 0.0055 16.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.4 NM_001270512.1_2 - 0.02 14.4 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.30 NM_029896.1_3 - 1.4e-18 66.8 9.4 9e-05 23.0 0.0 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_029896.1_3 - 1.2e-10 41.4 0.0 0.041 14.0 0.0 4.3 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain MACPF PF01823.17 NM_133882.2_1 - 3.2e-34 118.7 0.1 9.9e-34 117.1 0.1 1.7 2 0 0 2 2 2 1 MAC/Perforin domain TSP_1 PF00090.17 NM_133882.2_1 - 3.8e-11 42.9 19.8 2.1e-06 27.7 8.9 3.2 2 0 0 2 2 2 2 Thrombospondin type 1 domain Ldl_recept_a PF00057.16 NM_133882.2_1 - 1.4e-09 37.9 9.3 5.4e-09 36.0 9.3 2.1 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Avl9 PF09794.7 NM_026437.3_2 - 1.2e-08 34.0 0.0 4.9e-06 25.4 0.0 2.1 1 1 1 2 2 2 2 Transport protein Avl9 SPA PF08616.8 NM_026437.3_2 - 3.6e-08 33.2 0.0 7.3e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis DUF2347 PF09804.7 NM_026437.3_2 - 0.00056 19.4 0.0 0.0013 18.2 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Sushi PF00084.18 NM_008358.2_2 - 0.00028 21.3 0.4 0.00073 20.0 0.4 1.8 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) DUF3180 PF11377.6 NM_008358.2_2 - 0.026 14.5 0.2 0.054 13.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3180) Thioredoxin_8 PF13905.4 NM_008750.5_1 - 5.2e-53 177.2 0.0 1.7e-29 101.9 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.4 NM_008750.5_1 - 2.9e-13 50.1 0.0 3.2e-08 33.8 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.19 NM_008750.5_1 - 3.5e-08 33.3 0.0 1.1e-07 31.6 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin PF00085.18 NM_008750.5_1 - 1.2e-06 28.3 0.0 0.00052 19.8 0.0 3.2 2 1 1 3 3 3 1 Thioredoxin Thioredoxin_6 PF13848.4 NM_008750.5_1 - 2.4e-06 27.5 0.0 7.4e-06 25.9 0.0 1.9 2 1 0 2 2 2 1 Thioredoxin-like domain Redoxin PF08534.8 NM_008750.5_1 - 3.9e-05 23.2 0.0 7.5e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.4 NM_008750.5_1 - 0.0002 21.3 0.0 0.0019 18.2 0.0 2.7 3 1 0 3 3 3 1 Thioredoxin-like Glutaredoxin PF00462.22 NM_008750.5_1 - 0.0037 17.3 0.5 0.016 15.3 0.0 2.3 3 0 0 3 3 3 1 Glutaredoxin SCO1-SenC PF02630.12 NM_008750.5_1 - 0.053 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 SCO1/SenC HyaE PF07449.9 NM_008750.5_1 - 0.055 13.3 0.1 22 4.9 0.0 3.0 4 0 0 4 4 4 0 Hydrogenase-1 expression protein HyaE Trypsin PF00089.24 NM_053260.3_3 - 3.2e-65 219.9 0.1 3.8e-65 219.6 0.1 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_053260.3_3 - 2.9e-08 34.6 0.1 4.9e-08 33.8 0.1 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_053260.3_3 - 0.0023 18.2 0.1 0.0037 17.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Chibby PF14645.4 NM_001164141.1_3 - 3.9e-13 49.7 23.7 1.4e-11 44.7 0.7 4.4 2 2 0 2 2 2 1 Chibby family ZapB PF06005.10 NM_001164141.1_3 - 0.011 16.0 4.8 0.011 16.0 4.8 3.9 3 1 0 3 3 3 0 Cell division protein ZapB bZIP_2 PF07716.13 NM_001164141.1_3 - 0.016 15.2 8.3 0.016 15.2 8.3 3.9 3 0 0 3 3 3 0 Basic region leucine zipper ABATE PF07336.9 NM_001164141.1_3 - 0.53 10.8 5.9 0.33 11.5 0.4 2.3 1 1 1 2 2 2 0 Putative stress-induced transcription regulator Latarcin PF10279.7 NM_001164141.1_3 - 2.7 8.3 9.2 0.11 12.8 0.5 2.6 1 1 1 2 2 2 0 Latarcin precursor betaPIX_CC PF16523.3 NM_001164141.1_3 - 9.7 5.9 16.3 0.26 11.0 1.5 3.7 2 2 2 4 4 4 0 betaPIX coiled coil Carboxyl_trans PF01039.20 NM_001311149.1_1 - 2.9e-167 557.2 0.1 6.8e-122 407.5 0.0 2.0 1 1 1 2 2 2 2 Carboxyl transferase domain Proteasome PF00227.24 NM_008945.3_3 - 8.5e-34 116.6 0.0 1.3e-33 116.0 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Aldo_ket_red PF00248.19 NM_001252655.1_1 - 1.2e-72 244.4 0.0 1.6e-72 244.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family 7tm_4 PF13853.4 NM_146576.1_1 - 2.1e-45 155.5 13.9 2.7e-45 155.1 13.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146576.1_1 - 1.5e-23 83.3 20.8 1.5e-23 83.3 20.8 2.0 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146576.1_1 - 5.6e-06 25.8 21.1 1.2e-05 24.7 21.1 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Baculo_11_kDa PF06143.9 NM_146576.1_1 - 0.066 12.7 0.2 0.066 12.7 0.2 2.1 2 0 0 2 2 2 0 Baculovirus 11 kDa family 7TM_GPCR_Srx PF10328.7 NM_146576.1_1 - 0.086 12.0 23.9 0.11 11.7 23.0 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx SLC3A2_N PF16028.3 NM_146576.1_1 - 0.2 11.1 1.9 0.5 9.8 0.1 2.4 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus WAP PF00095.19 NM_001161806.1_1 - 1.6 9.0 12.3 2.7 8.3 12.3 1.3 1 0 0 1 1 1 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' Ank_2 PF12796.5 NM_172922.3_1 - 1.1e-65 218.1 8.2 1.3e-18 67.2 0.3 6.6 1 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_172922.3_1 - 4e-59 196.1 12.2 1.1e-09 38.5 0.0 7.9 4 3 4 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.28 NM_172922.3_1 - 7.3e-58 190.5 26.6 0.00011 22.3 0.2 12.0 12 0 0 12 12 12 11 Ankyrin repeat Ank_3 PF13606.4 NM_172922.3_1 - 1.3e-52 169.5 15.2 0.0017 18.5 0.0 11.9 12 0 0 12 12 12 11 Ankyrin repeat Pkinase_Tyr PF07714.15 NM_172922.3_1 - 6.9e-46 156.5 0.3 1.4e-45 155.5 0.1 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Ank_5 PF13857.4 NM_172922.3_1 - 5.6e-45 150.5 35.7 1.4e-08 34.7 2.1 8.5 3 2 7 10 10 10 10 Ankyrin repeats (many copies) Pkinase PF00069.23 NM_172922.3_1 - 6.9e-43 146.8 0.0 1e-42 146.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SKA2 PF16740.3 NM_025377.3_3 - 2.3e-34 117.4 6.6 2.9e-34 117.0 6.6 1.1 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 GAS PF13851.4 NM_025377.3_3 - 0.4 9.9 6.9 0.55 9.4 6.9 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding zf-RING_2 PF13639.4 NM_134064.2_2 - 2.6e-13 49.8 6.3 9.2e-13 48.1 6.3 2.1 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.5 NM_134064.2_2 - 1.2e-08 35.0 5.7 3.9e-08 33.3 5.7 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 NM_134064.2_2 - 2.6e-08 33.5 5.6 7e-08 32.1 5.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_134064.2_2 - 4.6e-08 32.7 4.9 1.1e-07 31.4 4.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 NM_134064.2_2 - 7e-08 31.9 3.4 7e-08 31.9 3.4 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.4 NM_134064.2_2 - 9e-07 28.5 3.6 2.9e-06 26.9 3.6 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_134064.2_2 - 1.2e-06 28.2 3.9 3.2e-06 26.9 3.9 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 NM_134064.2_2 - 0.00011 22.0 2.7 0.00041 20.2 2.7 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 NM_134064.2_2 - 0.0022 17.9 1.1 0.0022 17.9 1.1 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.3 NM_134064.2_2 - 0.15 11.5 4.5 0.33 10.5 4.5 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.5 NM_134064.2_2 - 0.95 9.5 5.4 2.1 8.4 5.4 1.7 1 0 0 1 1 1 0 RING-variant domain Calreticulin PF00262.16 NM_001285898.1_2 - 1.7e-76 257.4 13.9 8.9e-58 195.8 4.5 2.2 1 1 1 2 2 2 2 Calreticulin family Nucleo_P87 PF07267.9 NM_001285898.1_2 - 4.5 5.9 7.2 6.8 5.3 7.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Peptidase_S8 PF00082.20 NM_001081454.2_1 - 7.5e-49 166.4 5.5 1e-48 166.0 5.5 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.18 NM_001081454.2_1 - 4.1e-29 100.3 0.0 7.2e-29 99.5 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.3 NM_001081454.2_1 - 5.9e-25 87.8 1.9 1.1e-24 86.9 1.9 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain Furin-like_2 PF15913.3 NM_001081454.2_1 - 0.012 15.6 1.1 0.012 15.6 1.1 2.0 1 1 1 2 2 2 0 Furin-like repeat, cysteine-rich VSP PF03302.11 NM_001081454.2_1 - 0.085 11.6 17.9 0.22 10.2 6.1 2.3 1 1 0 2 2 2 0 Giardia variant-specific surface protein DUF357 PF04010.11 NM_001081454.2_1 - 0.091 12.7 0.2 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF357) GF_recep_IV PF14843.4 NM_001081454.2_1 - 0.16 11.6 19.0 1.7 8.3 19.0 2.3 1 1 0 1 1 1 0 Growth factor receptor domain IV HAGH_C PF16123.3 NM_024284.2_2 - 1.4e-27 95.9 0.2 2.5e-27 95.1 0.2 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 NM_024284.2_2 - 9.7e-12 45.2 3.2 2.8e-09 37.1 3.2 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 NM_024284.2_2 - 0.002 17.6 1.0 0.0033 16.8 0.4 1.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain DUF1899 PF08953.9 NM_011778.2_2 - 1.2e-33 114.6 0.1 2.3e-33 113.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 NM_011778.2_2 - 5.1e-20 71.0 0.9 8.8e-20 70.2 0.1 1.8 2 0 0 2 2 2 1 Type of WD40 repeat WD40 PF00400.30 NM_011778.2_2 - 3.8e-13 49.5 8.7 9.9e-05 22.9 0.2 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_011778.2_2 - 1.9e-06 27.9 0.1 0.0021 18.2 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Trimer_CC PF08954.9 NM_011778.2_2 - 0.007 15.8 4.1 0.91 9.0 3.9 2.5 2 0 0 2 2 2 2 Trimerisation motif RRM_1 PF00076.20 NM_028364.2_2 - 3.6e-44 148.3 0.1 1.4e-18 66.3 0.0 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_028364.2_2 - 0.00037 20.4 0.4 1.2 9.1 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif OB_RNB PF08206.9 NM_028364.2_2 - 0.086 12.4 0.1 6.5 6.4 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain PP2C PF00481.19 NM_001159498.1_1 - 3e-83 279.3 0.0 3.8e-83 278.9 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.11 NM_001159498.1_1 - 2e-32 111.3 0.0 3.4e-32 110.6 0.0 1.4 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain PP2C_2 PF13672.4 NM_001159498.1_1 - 0.0072 15.8 0.0 0.017 14.6 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C Tetraspannin PF00335.18 NM_001111050.1_2 - 6.7e-50 169.7 13.0 9.5e-50 169.2 13.0 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF4199 PF13858.4 NM_001111050.1_2 - 8.3e-06 26.2 1.1 1.7e-05 25.2 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) CD20 PF04103.13 NM_001111050.1_2 - 8.3e-05 22.6 8.0 0.00016 21.7 7.7 1.7 1 1 0 1 1 1 1 CD20-like family SUR7 PF06687.10 NM_001111050.1_2 - 0.0032 17.0 4.1 0.0064 16.0 4.1 1.5 1 0 0 1 1 1 1 SUR7/PalI family DUF2569 PF10754.7 NM_001111050.1_2 - 0.14 12.4 6.5 0.31 11.3 6.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) DUF373 PF04123.11 NM_001111050.1_2 - 1.8 7.8 5.5 3.2 7.0 5.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF308 PF03729.11 NM_001111050.1_2 - 1.9 8.7 17.2 0.32 11.2 7.4 2.7 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) NfeD PF01957.16 NM_001111050.1_2 - 3.6 7.9 5.9 1.7 8.9 3.2 1.8 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding Rubi_NSP_C PF12601.6 NM_001111050.1_3 - 0.04 13.9 0.3 0.18 11.8 0.2 2.0 2 0 0 2 2 2 0 Rubivirus non-structural protein MAM PF00629.21 NM_001287103.1_3 - 1.1e-20 73.9 0.0 2.7e-20 72.7 0.0 1.6 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu EGF_CA PF07645.13 NM_001287103.1_3 - 1.4e-20 73.0 35.3 1.8e-10 40.7 9.6 6.4 6 1 1 7 7 7 3 Calcium-binding EGF domain cEGF PF12662.5 NM_001287103.1_3 - 3.5e-20 71.5 36.5 3.3e-08 33.2 0.4 5.8 5 0 0 5 5 5 5 Complement Clr-like EGF-like EGF_3 PF12947.5 NM_001287103.1_3 - 6.5e-08 32.5 19.1 8.8e-08 32.1 10.5 6.1 6 0 0 6 6 6 3 EGF domain FXa_inhibition PF14670.4 NM_001287103.1_3 - 4.8e-06 26.6 74.3 0.00017 21.6 5.7 5.9 4 1 1 5 5 5 4 Coagulation Factor Xa inhibitory site C_tripleX PF02363.17 NM_001287103.1_3 - 0.0092 16.0 9.8 0.084 13.0 9.8 2.9 1 0 0 1 1 1 1 Cysteine rich repeat hEGF PF12661.5 NM_001287103.1_3 - 1.5 9.4 49.0 0.9 10.2 1.2 6.5 5 0 0 5 5 5 0 Human growth factor-like EGF EGF PF00008.25 NM_001287103.1_3 - 6.2 7.1 87.0 0.17 12.1 8.4 7.2 7 1 0 7 7 7 0 EGF-like domain Iso_dh PF00180.18 NM_173011.2_3 - 6.5e-76 255.6 0.0 7.7e-76 255.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Spore-coat_CotZ PF10612.7 NM_001081012.1_1 - 4.9 7.1 11.7 1.2 9.2 0.5 4.0 3 1 0 3 3 3 0 Spore coat protein Z Apyrase PF06079.9 NM_001025617.2_2 - 2.6e-131 437.0 0.1 3.2e-131 436.8 0.1 1.1 1 0 0 1 1 1 1 Apyrase Cpn10 PF00166.19 NM_008303.4_2 - 1e-29 102.3 0.1 1.4e-29 101.8 0.1 1.2 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Mcm10 PF09332.9 NM_027290.3_3 - 4.9e-143 476.7 11.2 4.9e-143 476.7 11.2 2.7 2 1 1 3 3 3 1 Mcm10 replication factor zf-primase PF09329.9 NM_027290.3_3 - 2.9e-18 65.3 2.2 6.8e-18 64.1 2.2 1.7 1 0 0 1 1 1 1 Primase zinc finger TPD52 PF04201.13 NM_027290.3_3 - 1.3 8.5 6.8 1.8 8.1 0.1 2.5 2 0 0 2 2 2 0 Tumour protein D52 family SlyX PF04102.10 NM_027290.3_3 - 8.8 6.9 10.7 0.3 11.6 3.2 2.5 2 0 0 2 2 2 0 SlyX Smoothelin PF12510.6 NM_001159284.1_2 - 2.1e-48 162.0 27.3 4.3e-21 74.6 0.8 3.9 4 0 0 4 4 4 3 Smoothelin cytoskeleton protein CH PF00307.29 NM_001159284.1_2 - 3.6e-24 84.9 0.0 3.4e-22 78.6 0.0 2.5 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_001159284.1_2 - 1.5e-05 24.6 0.0 3e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain Peptidase_M3_N PF08439.8 NM_001159284.1_2 - 0.13 12.4 8.9 4.2 7.6 1.3 3.3 3 0 0 3 3 3 0 Oligopeptidase F EBP PF05241.10 NM_026598.3_2 - 4.2e-61 205.3 11.3 6.5e-61 204.7 11.3 1.3 1 0 0 1 1 1 1 Emopamil binding protein HisKA_4TM PF16926.3 NM_026598.3_2 - 0.03 13.8 1.0 1.6 8.1 0.2 2.3 2 0 0 2 2 2 0 Archaeal 4TM region of histidine kinase HEAT PF02985.20 NM_027741.3_1 - 2.4e-07 30.3 1.5 0.1 12.7 0.0 4.0 4 0 0 4 4 4 3 HEAT repeat HEAT_EZ PF13513.4 NM_027741.3_1 - 7.5e-05 23.0 0.1 0.062 13.6 0.0 2.7 3 0 0 3 3 3 2 HEAT-like repeat HEAT_2 PF13646.4 NM_027741.3_1 - 0.07 13.4 0.0 5.2 7.4 0.0 2.4 2 1 0 2 2 2 0 HEAT repeats Cnd1 PF12717.5 NM_027741.3_1 - 0.11 12.4 0.0 0.48 10.3 0.0 1.9 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 AT_hook PF02178.17 NM_001166542.1_2 - 7.2 6.7 39.0 6.7 6.8 10.1 3.9 3 0 0 3 3 3 0 AT hook motif IPP-2 PF04979.12 NM_001316698.1_1 - 7.9e-28 97.7 3.0 7.9e-28 97.7 3.0 2.0 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) Zip PF02535.20 NM_001135151.1_1 - 5.4e-66 222.9 8.6 9.7e-66 222.1 8.6 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter ANAPC4_WD40 PF12894.5 NM_134126.3_2 - 1.1e-07 31.9 0.4 0.018 15.2 0.0 4.1 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.18 NM_134126.3_2 - 1.2e-05 25.1 27.8 0.013 15.3 0.1 7.1 5 1 3 8 8 8 4 Region in Clathrin and VPS Coatomer_WDAD PF04053.12 NM_134126.3_2 - 0.00017 20.7 29.4 0.21 10.5 0.0 6.8 6 2 3 9 9 9 3 Coatomer WD associated region Exo84_C PF16528.3 NM_134126.3_2 - 0.016 14.9 0.3 0.042 13.5 0.3 1.7 1 0 0 1 1 1 0 Exocyst component 84 C-terminal RNase_HII PF01351.16 NM_134126.3_2 - 0.019 14.7 0.7 0.038 13.7 0.7 1.4 1 0 0 1 1 1 0 Ribonuclease HII tRNA_int_end_N2 PF12928.5 NM_134126.3_2 - 0.02 14.9 0.0 0.11 12.5 0.0 2.3 2 0 0 2 2 2 0 tRNA-splicing endonuclease subunit sen54 N-term WD40 PF00400.30 NM_134126.3_2 - 0.021 15.5 2.2 8.3 7.3 0.0 5.2 6 0 0 6 6 6 0 WD domain, G-beta repeat TPR_7 PF13176.4 NM_134126.3_2 - 0.024 14.5 26.8 1.5 8.9 0.1 10.2 7 3 4 11 11 11 0 Tetratricopeptide repeat SGL PF08450.10 NM_134126.3_2 - 0.13 11.7 0.1 26 4.2 0.0 3.6 3 1 1 4 4 4 0 SMP-30/Gluconolaconase/LRE-like region PPR PF01535.18 NM_134126.3_2 - 0.47 10.7 8.9 13 6.2 0.1 5.8 6 0 0 6 6 6 0 PPR repeat 7tm_4 PF13853.4 NM_146820.2_1 - 1.1e-93 313.9 24.1 1.2e-93 313.7 24.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146820.2_1 - 5.6e-16 58.4 21.8 1.6e-15 56.9 21.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146820.2_1 - 3.8e-09 36.2 16.3 1e-08 34.8 16.3 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx MHC_I PF00129.16 NM_010380.3_3 - 4.5e-90 299.9 2.4 5.8e-90 299.5 2.4 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_010380.3_3 - 1.1e-15 57.7 0.0 2.1e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 NM_010380.3_3 - 4.2e-05 23.3 1.4 0.0001 22.0 1.4 1.7 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 NM_010380.3_3 - 0.00015 22.2 0.1 0.032 14.7 0.1 2.5 1 1 1 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_010380.3_3 - 0.0012 18.8 0.0 0.0022 18.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_010380.3_3 - 0.0033 17.6 0.0 0.0079 16.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 NM_010380.3_3 - 0.01 15.8 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Marek_A PF02124.13 NM_010380.3_3 - 0.089 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A zf-RING_2 PF13639.4 NM_198251.2_3 - 4.7e-13 49.0 7.2 8.7e-13 48.2 7.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.3 NM_198251.2_3 - 1.2e-07 31.2 5.7 2.3e-07 30.3 5.7 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.5 NM_198251.2_3 - 1.5e-07 31.4 5.9 3.5e-07 30.3 5.9 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 NM_198251.2_3 - 2.1e-07 30.5 7.2 3.7e-07 29.7 7.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_198251.2_3 - 4.3e-07 29.5 7.6 7.5e-07 28.8 7.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.20 NM_198251.2_3 - 4.6e-07 29.7 0.1 8.8e-07 28.8 0.1 1.4 1 0 0 1 1 1 1 PA domain zf-RING_5 PF14634.4 NM_198251.2_3 - 1.3e-06 28.1 9.3 2.5e-06 27.2 9.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 NM_198251.2_3 - 0.00049 19.8 7.0 0.00078 19.1 7.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_198251.2_3 - 0.0028 17.3 8.2 0.0049 16.6 8.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.4 NM_198251.2_3 - 0.0057 16.5 9.5 0.013 15.4 9.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 NM_198251.2_3 - 0.012 15.5 6.5 0.046 13.6 6.5 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_16 PF17034.3 NM_198251.2_3 - 0.041 14.0 1.7 0.073 13.2 1.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon like family Zn_ribbon_17 PF17120.3 NM_198251.2_3 - 0.07 12.6 5.5 0.13 11.8 5.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.3 NM_198251.2_3 - 0.13 12.2 2.9 0.35 10.8 2.9 1.8 1 0 0 1 1 1 0 Zinc-finger PHD PF00628.27 NM_198251.2_3 - 0.99 9.2 7.7 2 8.3 7.7 1.5 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.3 NM_198251.2_3 - 1.6 8.8 5.9 0.71 9.9 2.9 2.0 2 0 0 2 2 2 0 KIAA1045 RING finger RINGv PF12906.5 NM_198251.2_3 - 2 8.5 8.0 4.2 7.4 8.0 1.5 1 0 0 1 1 1 0 RING-variant domain Mito_carr PF00153.25 NM_001085497.2_2 - 3.4e-63 209.5 3.0 8.5e-23 80.0 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3429 PF11911.6 NM_177670.4_1 - 8.3e-32 110.3 7.8 1.2e-31 109.8 7.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) SAA PF00277.16 NM_011314.2_1 - 1.4e-46 157.1 3.5 1.9e-46 156.7 3.5 1.2 1 0 0 1 1 1 1 Serum amyloid A protein DDHD PF02862.15 NM_001034103.1_1 - 1.2 9.1 14.9 1.3 9.0 14.9 1.2 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.10 NM_001034103.1_1 - 2.7 6.7 11.3 3.1 6.5 11.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Neur_chan_memb PF02932.14 NM_001034103.1_1 - 2.8 7.8 11.3 2.9 7.7 11.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AAA_11 PF13086.4 NM_001034103.1_2 - 0.022 14.4 21.2 0.03 13.9 21.2 1.2 1 0 0 1 1 1 0 AAA domain zf-C3HC4 PF00097.23 NM_001034103.1_2 - 0.055 13.2 2.1 0.059 13.1 0.1 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF913 PF06025.10 NM_001034103.1_2 - 0.85 8.4 10.9 0.88 8.3 10.9 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SpoIIP PF07454.9 NM_001034103.1_2 - 2.7 7.2 26.5 4.4 6.5 26.5 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RNA_pol_Rpc4 PF05132.12 NM_001034103.1_3 - 0.0023 18.3 17.6 0.0027 18.1 17.6 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 EOS1 PF12326.6 NM_001034103.1_3 - 5.1 6.9 13.0 7 6.4 13.0 1.4 1 0 0 1 1 1 0 N-glycosylation protein Chorein_N PF12624.5 NM_001080769.1_2 - 1e-15 57.8 0.1 4.4e-15 55.7 0.0 2.1 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 Connexin PF00029.17 NM_001160012.1_1 - 4.3e-79 265.3 8.2 6.3e-79 264.8 8.2 1.3 1 0 0 1 1 1 1 Connexin Pkinase PF00069.23 NM_001286066.1_1 - 2.4e-51 174.5 0.0 3e-51 174.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001286066.1_1 - 1.3e-25 90.1 0.0 1.6e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001286066.1_1 - 0.00012 21.3 0.0 0.00019 20.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RGS PF00615.17 NM_001286066.1_2 - 1.1e-18 67.4 0.0 2.9e-18 66.1 0.0 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain Pkinase PF00069.23 NM_001286066.1_2 - 9.9e-08 31.5 0.9 1.3e-07 31.1 0.9 1.1 1 0 0 1 1 1 1 Protein kinase domain 7tm_4 PF13853.4 NM_146909.1_1 - 1e-49 169.7 24.0 1.2e-49 169.5 24.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146909.1_1 - 6.9e-26 90.9 25.8 2.6e-25 89.0 25.8 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1669 PF07894.10 NM_001045518.1_1 - 5.1e-106 354.1 0.2 5.1e-106 354.1 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1669) PLDc_2 PF13091.4 NM_001045518.1_1 - 5.1e-10 39.2 0.3 1.2e-09 38.1 0.3 1.7 1 0 0 1 1 1 1 PLD-like domain Regulator_TrmB PF11495.6 NM_001045518.1_1 - 0.046 12.8 0.0 0.083 11.9 0.0 1.3 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB Cript PF10235.7 NM_019936.3_1 - 9e-35 119.0 6.7 9e-35 119.0 6.7 1.6 2 0 0 2 2 2 1 Microtubule-associated protein CRIPT DUF2757 PF10955.6 NM_019936.3_1 - 0.12 12.6 0.1 0.12 12.6 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2757) DUF2039 PF10217.7 NM_019936.3_1 - 0.25 11.6 14.0 2 8.7 14.0 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) Gin PF10764.7 NM_019936.3_1 - 1.2 9.0 6.9 5.4 6.9 0.1 2.5 2 1 0 2 2 2 0 Inhibitor of sigma-G Gin Smg4_UPF3 PF03467.13 NM_025924.2_1 - 3.2e-51 173.7 0.2 3.2e-51 173.7 0.2 2.5 2 1 0 2 2 2 1 Smg-4/UPF3 family SH2 PF00017.22 NM_013748.3_3 - 2.9e-15 56.0 0.1 6.2e-15 54.9 0.1 1.6 1 0 0 1 1 1 1 SH2 domain Fibrinogen_C PF00147.16 NM_007995.3_1 - 3e-74 249.4 6.5 3.7e-74 249.1 6.5 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Collagen PF01391.16 NM_007995.3_1 - 1.2e-08 34.4 28.2 1.2e-08 34.4 28.2 1.7 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) DAG_kinase_N PF14513.4 NM_007995.3_1 - 0.0097 16.0 0.1 0.014 15.5 0.1 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus Pkinase PF00069.23 NM_008927.3_2 - 2.3e-61 207.3 0.0 3.2e-61 206.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_008927.3_2 - 9.6e-34 116.7 0.0 2.4e-32 112.1 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.9 NM_008927.3_2 - 0.038 12.9 0.0 0.057 12.3 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.4 NM_008927.3_2 - 0.076 12.2 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF3216 PF11505.6 NM_008927.3_2 - 0.14 12.3 0.3 0.28 11.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) DUF1356 PF07092.10 NM_027992.3_3 - 7.4e-117 388.5 4.3 1.2e-116 387.8 4.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) P2X_receptor PF00864.17 NM_011027.3_2 - 9.6e-155 515.0 6.1 1.2e-154 514.7 6.1 1.1 1 0 0 1 1 1 1 ATP P2X receptor Keratin_matx PF04579.10 NM_011027.3_2 - 0.00054 20.1 1.8 0.00054 20.1 1.8 3.0 3 0 0 3 3 3 1 Keratin, high-sulphur matrix protein Troponin PF00992.18 NM_001130176.1_3 - 6.2e-35 120.3 52.9 1.3e-30 106.3 38.7 3.5 3 1 1 4 4 4 2 Troponin SRCR PF00530.16 NM_028903.2_3 - 5.9e-31 106.8 3.4 5.9e-31 106.8 3.4 1.9 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Collagen PF01391.16 NM_028903.2_3 - 1.3e-13 50.4 56.6 2.3e-08 33.6 22.2 2.6 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) SRCR_2 PF15494.4 NM_028903.2_3 - 6.1e-05 23.3 1.6 8.6e-05 22.9 0.1 2.0 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain IncA PF04156.12 NM_028903.2_3 - 0.81 9.3 6.0 1.4 8.5 6.0 1.4 1 0 0 1 1 1 0 IncA protein Mpv17_PMP22 PF04117.10 NM_001294322.1_1 - 3.1e-13 49.6 4.5 7e-13 48.4 4.5 1.6 1 1 0 1 1 1 1 Mpv17 / PMP22 family DDE_Tnp_1_7 PF13843.4 NM_001012311.2_1 - 5.4e-47 160.7 1.7 2.2e-41 142.2 0.3 2.1 2 0 0 2 2 2 2 Transposase IS4 DDE_Tnp_1_7 PF13843.4 NM_001012311.2_2 - 6.5e-12 45.3 0.0 9.4e-12 44.8 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 KIND PF16474.3 NM_194355.2_2 - 2.2e-27 96.1 0.4 2.2e-27 96.1 0.4 1.8 2 0 0 2 2 2 1 Kinase non-catalytic C-lobe domain FYVE PF01363.19 NM_194355.2_2 - 0.012 15.6 9.5 0.035 14.1 9.5 1.8 1 0 0 1 1 1 0 FYVE zinc finger HAT_KAT11 PF08214.9 NM_001025432.1_2 - 4.1e-68 230.1 0.5 4.1e-68 230.1 0.5 2.4 3 0 0 3 3 3 1 Histone acetylation protein KIX PF02172.14 NM_001025432.1_2 - 3.6e-39 132.8 0.4 7.8e-39 131.7 0.4 1.6 1 0 0 1 1 1 1 KIX domain Creb_binding PF09030.8 NM_001025432.1_2 - 9.6e-35 119.4 17.2 9.6e-35 119.4 17.2 11.8 10 1 2 12 12 12 1 Creb binding zf-TAZ PF02135.14 NM_001025432.1_2 - 2.5e-28 98.2 71.7 6.5e-19 68.1 20.6 3.8 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.11 NM_001025432.1_2 - 8e-22 77.3 9.1 8e-22 77.3 9.1 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.23 NM_001025432.1_2 - 8.5e-17 60.9 0.1 2.3e-16 59.5 0.1 1.7 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.15 NM_001025432.1_2 - 1.4e-15 56.7 14.4 1.4e-15 56.7 14.4 3.1 3 0 0 3 3 3 1 Zinc finger, ZZ type KIX_2 PF16987.3 NM_001025432.1_2 - 5.1e-05 23.1 0.1 5.1e-05 23.1 0.1 2.6 2 0 0 2 2 2 1 KIX domain Npa1 PF11707.6 NM_001025432.1_2 - 0.0048 16.2 0.0 0.0084 15.4 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal Serglycin PF04360.10 NM_011157.2_3 - 3.4e-65 218.4 0.1 4.2e-65 218.1 0.1 1.1 1 0 0 1 1 1 1 Serglycin DUF4041 PF13250.4 NM_172535.3_3 - 0.013 15.3 0.0 0.036 13.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) IQ PF00612.25 NM_172535.3_3 - 0.033 13.8 0.4 0.13 12.0 0.4 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif Serpin PF00079.18 NM_009253.2_1 - 1.5e-122 409.4 4.1 1.8e-122 409.1 4.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF531 PF04407.10 NM_009253.2_1 - 0.044 13.7 0.1 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF531) LRR_8 PF13855.4 NM_026668.2_3 - 2.8e-48 161.4 57.2 6.1e-09 35.4 1.6 8.4 6 2 1 8 8 8 7 Leucine rich repeat LRR_4 PF12799.5 NM_026668.2_3 - 3.1e-33 113.0 67.0 1.1e-05 25.5 1.4 11.3 5 1 6 13 13 13 13 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_026668.2_3 - 1.2e-12 47.6 26.1 0.00025 20.5 0.1 5.3 3 1 2 5 5 5 5 Leucine-rich repeat IQ PF00612.25 NM_026668.2_3 - 0.0004 19.8 0.4 0.0011 18.4 0.4 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif LRR_1 PF00560.31 NM_026668.2_3 - 0.0037 17.4 72.5 0.58 10.7 0.2 16.0 16 3 1 17 17 17 4 Leucine Rich Repeat RsmF_methylt_CI PF17126.3 NM_026668.2_3 - 0.013 15.4 4.3 39 4.3 0.0 5.8 6 0 0 6 6 6 0 RsmF rRNA methyltransferase first C-terminal domain Aldolase_II PF00596.19 NM_001271860.1_1 - 7.9e-37 126.9 0.1 1.2e-36 126.2 0.1 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Occludin_ELL PF07303.11 NM_001271860.1_1 - 0.1 13.2 0.1 0.21 12.2 0.1 1.4 1 0 0 1 1 1 0 Occludin homology domain Oxidored-like PF09791.7 NM_009681.5_2 - 0.22 11.1 3.2 0.88 9.1 3.2 2.0 1 0 0 1 1 1 0 Oxidoreductase-like protein, N-terminal Clat_adaptor_s PF01217.18 NM_009681.5_3 - 4.5e-53 178.9 2.0 6.4e-53 178.4 2.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DNA_methylase PF00145.15 NM_001199433.1_3 - 2.2e-47 161.9 2.3 7e-47 160.2 0.0 2.7 2 2 0 2 2 2 1 C-5 cytosine-specific DNA methylase DNMT1-RFD PF12047.6 NM_001199433.1_3 - 3.1e-45 153.6 0.0 1.6e-44 151.3 0.0 2.2 2 0 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain BAH PF01426.16 NM_001199433.1_3 - 8.9e-43 144.9 0.3 1.1e-20 73.6 0.1 2.9 3 0 0 3 3 3 2 BAH domain zf-CXXC PF02008.18 NM_001199433.1_3 - 5.3e-15 55.0 21.1 1.8e-14 53.3 21.1 2.0 1 0 0 1 1 1 1 CXXC zinc finger domain DMAP_binding PF06464.9 NM_001199433.1_3 - 5.7e-15 56.0 2.2 5.7e-15 56.0 2.2 3.0 3 0 0 3 3 3 1 DMAP1-binding Domain DUF4770 PF15994.3 NM_001199433.1_3 - 8.5 6.4 7.3 11 6.0 5.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4770) Ldl_recept_a PF00057.16 NM_172631.3_2 - 1.5e-07 31.3 9.4 3.9e-07 30.0 9.4 1.7 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF2615 PF11027.6 NM_172631.3_2 - 0.047 13.7 0.1 0.09 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) SP_C-Propep PF08999.8 NM_172631.3_2 - 0.25 11.0 2.9 0.7 9.6 2.9 1.7 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide IPK PF03770.14 NM_181593.2_3 - 2e-39 135.4 0.0 5.5e-39 133.9 0.0 1.8 2 1 0 2 2 2 1 Inositol polyphosphate kinase HIN PF02760.13 NM_011940.2_3 - 5.2e-124 410.0 16.5 7.1e-65 217.6 10.2 2.1 2 0 0 2 2 2 2 HIN-200/IF120x domain tRNA_anti-codon PF01336.23 NM_011940.2_3 - 0.021 14.7 1.4 5.3 7.0 0.1 3.8 4 0 0 4 4 4 0 OB-fold nucleic acid binding domain EKR PF10371.7 NM_011940.2_3 - 0.062 13.0 0.0 0.27 10.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function I-set PF07679.14 NM_001171512.2_1 - 0 2385.3 67.7 1.5e-21 76.1 0.0 59.9 58 2 2 60 60 60 58 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001171512.2_1 - 0 1640.5 63.1 3.4e-13 49.9 0.0 58.4 59 0 0 59 59 59 55 Immunoglobulin domain ig PF00047.23 NM_001171512.2_1 - 0 1179.9 107.0 6.9e-09 35.6 0.6 55.2 55 0 0 55 55 55 51 Immunoglobulin domain Ig_2 PF13895.4 NM_001171512.2_1 - 0 1032.3 52.3 1.2e-08 35.0 0.0 53.3 52 3 2 55 55 54 49 Immunoglobulin domain V-set PF07686.15 NM_001171512.2_1 - 9.3e-138 450.4 155.1 0.0022 18.0 0.1 76.0 53 39 0 53 53 53 38 Immunoglobulin V-set domain Pkinase PF00069.23 NM_001171512.2_1 - 3e-106 354.5 0.0 1.1e-61 208.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_5 PF16681.3 NM_001171512.2_1 - 5.4e-57 190.0 73.8 0.021 15.1 0.3 40.9 44 0 0 44 44 42 9 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pkinase_Tyr PF07714.15 NM_001171512.2_1 - 1e-56 192.0 0.0 2.5e-29 102.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Ig_4 PF16680.3 NM_001171512.2_1 - 3.2e-44 149.0 71.0 0.13 12.5 0.2 39.3 41 0 0 41 41 38 4 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 NM_001171512.2_1 - 8.6e-39 131.3 88.6 0.14 12.1 0.1 44.3 49 0 0 49 49 48 4 Izumo-like Immunoglobulin domain C1-set PF07654.13 NM_001171512.2_1 - 2e-36 124.2 35.3 0.39 11.1 0.0 31.3 32 0 0 32 32 30 2 Immunoglobulin C1-set domain C2-set_2 PF08205.10 NM_001171512.2_1 - 3.2e-31 107.1 95.0 0.15 12.0 0.0 34.3 37 0 0 37 37 35 6 CD80-like C2-set immunoglobulin domain fn3 PF00041.19 NM_001171512.2_1 - 3.6e-24 84.8 0.0 3.9e-12 46.2 0.0 4.1 3 0 0 3 3 3 2 Fibronectin type III domain BiPBP_C PF06832.10 NM_001171512.2_1 - 5.1e-23 80.8 13.3 1.4 8.9 0.0 24.9 27 0 0 27 27 25 1 Penicillin-Binding Protein C-terminus Family RhoGEF PF00621.18 NM_001171512.2_1 - 4.4e-19 69.3 0.4 7.9e-19 68.5 0.4 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 NM_001171512.2_1 - 6.1e-06 26.6 0.1 3e-05 24.3 0.1 2.3 1 0 0 1 1 1 1 PH domain 1-cysPrx_C PF10417.7 NM_001171512.2_1 - 2.7e-05 23.8 0.3 1.7 8.4 0.0 7.2 9 0 0 9 9 9 1 C-terminal domain of 1-Cys peroxiredoxin IQ PF00612.25 NM_001171512.2_1 - 0.0001 21.6 0.1 0.00031 20.2 0.1 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif APH PF01636.21 NM_001171512.2_1 - 0.00068 19.5 3.1 0.25 11.1 0.1 3.3 3 0 0 3 3 2 2 Phosphotransferase enzyme family PKD_3 PF16820.3 NM_001171512.2_1 - 0.0013 18.3 0.8 30 4.3 0.0 8.3 6 0 0 6 6 6 0 PKD-like domain ACAS_N PF16177.3 NM_001171512.2_1 - 0.012 15.4 14.5 20 5.1 0.0 11.8 17 0 0 17 17 15 0 Acetyl-coenzyme A synthetase N-terminus CBM_15 PF03426.12 NM_001171512.2_1 - 0.02 14.4 28.0 31 4.0 0.1 12.0 9 2 1 11 11 11 0 Carbohydrate binding domain (family 15) Kdo PF06293.12 NM_001171512.2_1 - 0.023 13.9 0.1 4.7 6.4 0.0 2.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family TOBE_2 PF08402.8 NM_001171512.2_1 - 0.034 14.2 6.8 5.2e+02 0.8 0.0 9.6 10 0 0 10 10 10 0 TOBE domain zf-RRN7 PF11781.6 NM_001171512.2_1 - 0.11 12.1 4.6 0.87 9.2 0.2 4.7 4 0 0 4 4 4 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 RasGEF PF00617.17 NM_009231.2_3 - 8.5e-48 162.6 0.3 1.4e-47 161.9 0.3 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 NM_009231.2_3 - 5.6e-31 106.8 0.0 1.6e-30 105.3 0.0 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif RhoGEF PF00621.18 NM_009231.2_3 - 3.6e-14 53.3 0.0 1.2e-13 51.6 0.0 1.9 1 0 0 1 1 1 1 RhoGEF domain Histone PF00125.22 NM_009231.2_3 - 2.9e-12 47.0 0.1 6e-12 46.0 0.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PH PF00169.27 NM_009231.2_3 - 9.6e-12 45.2 0.0 3.4e-11 43.4 0.0 2.0 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.3 NM_009231.2_3 - 0.0048 16.8 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 NM_009231.2_3 - 0.008 16.3 0.2 0.023 14.8 0.2 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.3 NM_009231.2_3 - 0.043 13.5 0.1 0.12 12.1 0.1 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain TFR_dimer PF04253.13 NM_016770.3_1 - 2.9e-34 117.6 0.0 5.2e-34 116.8 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.15 NM_016770.3_1 - 2.5e-16 59.8 0.0 6.2e-16 58.5 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.20 NM_016770.3_1 - 1.8e-11 43.8 0.0 3.8e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 PA domain DUF1049 PF06305.9 NM_016770.3_1 - 0.76 9.5 2.0 1.7 8.4 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) SNF PF00209.16 NM_139142.2_3 - 2.9e-175 583.8 31.9 3.8e-175 583.4 31.9 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family LRR_8 PF13855.4 NM_212484.2_3 - 1.5e-14 53.3 15.1 1.4e-10 40.6 6.1 3.2 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 NM_212484.2_3 - 4.2e-11 42.7 12.0 7.4e-07 29.2 1.5 3.0 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) Exo_endo_phos PF03372.21 NM_212484.2_3 - 7.3e-09 35.7 0.0 1.2e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_6 PF13516.4 NM_212484.2_3 - 0.026 14.4 14.4 0.93 9.6 0.3 4.7 4 0 0 4 4 4 0 Leucine Rich repeat Pkinase PF00069.23 NM_010019.3_2 - 5.2e-74 248.8 0.0 6.8e-74 248.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_010019.3_2 - 4.8e-35 120.9 0.0 6.4e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.20 NM_010019.3_2 - 0.00015 21.3 0.1 0.00027 20.4 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 NM_010019.3_2 - 0.001 18.3 0.0 0.0022 17.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Glycos_trans_3N PF02885.15 NM_010019.3_2 - 0.16 11.6 0.5 0.74 9.6 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain zf-H2C2_2 PF13465.4 NM_181650.3_1 - 2.5e-24 84.4 55.4 2.4e-07 30.7 0.8 7.8 8 1 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_181650.3_1 - 5.1e-19 67.5 62.6 2e-05 24.7 1.8 8.4 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_181650.3_1 - 5.7e-15 54.6 63.9 0.0015 19.1 1.6 9.1 9 0 0 9 9 9 6 C2H2-type zinc finger zf-met PF12874.5 NM_181650.3_1 - 9.5e-09 35.2 41.5 0.0003 20.9 1.3 7.3 7 0 0 7 7 7 4 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 NM_181650.3_1 - 0.0023 17.5 8.5 0.005 16.4 1.2 5.8 6 0 0 6 6 6 3 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 NM_181650.3_1 - 0.01 16.0 49.3 0.064 13.5 0.1 7.7 8 0 0 8 8 8 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_181650.3_1 - 0.18 11.7 35.1 0.39 10.6 0.5 6.5 6 0 0 6 6 6 0 C2H2-type zinc finger Mu-like_Com PF10122.7 NM_181650.3_1 - 0.21 10.9 5.4 0.14 11.5 2.8 2.1 2 1 0 2 2 2 0 Mu-like prophage protein Com HypA PF01155.17 NM_181650.3_1 - 1.5 8.7 13.9 0.27 11.1 0.8 3.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3220 PF11516.6 NM_028120.2_1 - 0.042 13.9 0.2 0.43 10.7 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3120) Reo_sigmaC PF04582.10 NM_028120.2_1 - 3 7.0 15.2 2.7 7.1 1.0 3.5 2 1 1 3 3 3 0 Reovirus sigma C capsid protein 7tm_4 PF13853.4 NM_146835.1_1 - 1e-53 182.8 20.2 1.2e-53 182.6 20.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146835.1_1 - 9.2e-23 80.7 24.3 1.9e-22 79.6 24.3 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146835.1_1 - 0.00079 18.8 22.7 0.0023 17.2 22.7 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx IL1 PF00340.17 NM_001146087.1_3 - 6.5e-21 74.1 0.0 1e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 PDGF PF00341.15 NM_001271705.1_3 - 1.1e-24 86.4 2.4 1.9e-24 85.6 2.4 1.4 1 0 0 1 1 1 1 PDGF/VEGF domain UPF0172 PF03665.11 NM_033146.1_2 - 4e-56 190.0 0.0 4.6e-56 189.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) TAFII55_N PF04658.11 NM_028958.4_3 - 2.6e-55 186.4 0.0 2.6e-55 186.4 0.0 1.7 2 0 0 2 2 2 1 TAFII55 protein conserved region Sigma70_ner PF04546.11 NM_028958.4_3 - 0.0094 15.7 7.9 0.017 14.9 7.9 1.4 1 0 0 1 1 1 1 Sigma-70, non-essential region CDC45 PF02724.12 NM_028958.4_3 - 0.77 7.9 9.8 1.1 7.3 9.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.11 NM_028958.4_3 - 2.1 6.2 17.8 3 5.7 17.8 1.3 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.9 NM_028958.4_3 - 7.1 4.9 10.0 9.5 4.5 10.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pyridoxal_deC PF00282.17 NM_008077.5_2 - 4.9e-151 502.6 0.0 6.1e-151 502.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 NM_008077.5_2 - 2.4e-05 23.3 0.0 0.00015 20.7 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 NM_008077.5_2 - 8e-05 21.9 0.0 0.00016 21.0 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.11 NM_008077.5_2 - 0.037 12.6 0.0 0.059 11.9 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DegT_DnrJ_EryC1 PF01041.15 NM_008077.5_2 - 0.05 12.8 0.0 0.071 12.3 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family OKR_DC_1 PF01276.18 NM_008077.5_2 - 0.067 11.8 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain RnaseA PF00074.18 NM_029145.3_3 - 1e-17 64.7 4.8 1.6e-17 64.0 4.8 1.2 1 0 0 1 1 1 1 Pancreatic ribonuclease CCDC74_C PF14917.4 NM_001166164.1_2 - 1.5e-45 154.4 3.4 1.5e-45 154.4 3.4 2.1 2 1 0 2 2 2 1 Coiled coil protein 74, C terminal CCDC92 PF14916.4 NM_001166164.1_2 - 7.5e-21 73.5 9.0 1.7e-20 72.4 9.0 1.6 1 0 0 1 1 1 1 Coiled-coil domain of unknown function LCD1 PF09798.7 NM_001166164.1_2 - 0.15 10.4 6.2 0.19 10.1 6.2 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein ACCA PF03255.12 NM_001166164.1_2 - 1 9.1 4.5 0.34 10.7 1.4 1.8 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF1658 PF07871.9 NM_001166164.1_2 - 3.1 7.8 7.0 1.5 8.8 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1658) SlyX PF04102.10 NM_001166164.1_2 - 4.2 7.9 7.5 2.4 8.7 2.1 2.9 2 0 0 2 2 2 0 SlyX GIT_CC PF16559.3 NM_001166164.1_2 - 8.6 6.4 9.1 7.9 6.5 1.6 2.7 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor GYF PF02213.14 NM_146112.4_2 - 7.3e-21 73.5 0.4 1.8e-20 72.3 0.4 1.7 1 0 0 1 1 1 1 GYF domain DUF4339 PF14237.4 NM_146112.4_2 - 0.0019 17.8 0.1 0.0063 16.2 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4339) PRTase_3 PF15610.4 NM_146112.4_2 - 0.036 13.2 0.2 0.078 12.1 0.2 1.5 1 0 0 1 1 1 0 PRTase ComF-like TPR_12 PF13424.4 NM_172526.3_3 - 7.6e-24 83.7 26.4 8.7e-08 32.2 1.1 5.7 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.26 NM_172526.3_3 - 1.4e-19 68.9 15.8 2.4e-05 23.8 2.0 7.7 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_10 PF13374.4 NM_172526.3_3 - 1.1e-12 47.3 10.7 0.011 15.4 1.5 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.15 NM_172526.3_3 - 2.1e-11 42.9 29.7 0.00017 21.3 3.3 8.4 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_172526.3_3 - 2.6e-10 39.5 12.3 0.0018 18.1 0.3 6.6 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_8 PF13181.4 NM_172526.3_3 - 9.1e-10 37.9 11.2 0.06 13.5 0.7 7.8 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_172526.3_3 - 1.6e-06 27.5 1.7 0.11 12.1 0.2 4.9 5 0 0 5 5 5 2 TPR repeat TPR_14 PF13428.4 NM_172526.3_3 - 0.00047 20.6 27.1 0.0047 17.5 1.1 7.3 6 2 1 7 7 7 2 Tetratricopeptide repeat TPR_4 PF07721.12 NM_172526.3_3 - 0.0023 18.2 26.4 0.4 11.3 0.2 6.4 6 1 0 6 6 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_172526.3_3 - 0.019 14.9 0.9 3.9 7.5 0.1 3.2 3 0 0 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_5 PF12688.5 NM_172526.3_3 - 0.039 14.0 6.4 1.1 9.3 0.7 2.9 3 0 0 3 3 2 0 Tetratrico peptide repeat TPR_16 PF13432.4 NM_172526.3_3 - 0.065 13.8 28.5 0.15 12.7 3.8 5.5 4 1 1 5 5 5 0 Tetratricopeptide repeat Wzy_C_2 PF11846.6 NM_172526.3_3 - 1.5 8.6 9.7 0.25 11.1 0.7 3.2 3 1 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal TPR_19 PF14559.4 NM_172526.3_3 - 4.1 7.8 18.3 3.5 8.1 0.6 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.16 NM_172526.3_3 - 4.1 7.4 10.5 2.9 7.9 0.2 4.8 6 1 1 7 7 7 0 MIT (microtubule interacting and transport) domain NuA4 PF09340.8 NM_027310.4_2 - 2.5e-27 94.4 2.3 2.5e-27 94.4 2.3 1.9 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 BBS2_C PF14782.4 NM_027310.4_2 - 0.13 10.9 0.2 0.23 10.1 0.2 1.4 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Pkinase PF00069.23 NM_009435.2_1 - 4.6e-66 222.7 0.1 5.6e-66 222.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_009435.2_1 - 6.3e-39 133.7 0.0 8.4e-39 133.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_009435.2_1 - 4.5e-10 39.2 0.0 7e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.7 NM_009435.2_1 - 0.0011 18.4 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.12 NM_009435.2_1 - 0.0022 17.3 0.0 0.0035 16.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Herpes_UL49_2 PF04823.10 NM_009435.2_2 - 0.069 13.1 1.1 0.15 12.0 1.1 1.5 1 0 0 1 1 1 0 Herpesvirus UL49 tegument protein Folliculin PF11704.6 NM_175491.4_3 - 4e-08 33.2 0.1 7.2e-08 32.4 0.1 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport C9orf72-like PF15019.4 NM_175491.4_3 - 0.023 14.1 0.0 0.56 9.6 0.0 2.3 2 0 0 2 2 2 0 C9orf72-like protein family CD20 PF04103.13 NM_010656.2_1 - 2.3e-28 99.1 17.0 3.6e-28 98.5 17.0 1.3 1 0 0 1 1 1 1 CD20-like family Reticulon PF02453.15 NM_019419.2_2 - 0.00067 19.5 2.1 0.0011 18.8 2.1 1.3 1 0 0 1 1 1 1 Reticulon PP1_inhibitor PF05361.10 NM_025746.2_2 - 2.1e-28 99.0 1.3 3.8e-28 98.1 1.3 1.3 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor HSBP1 PF06825.10 NM_001136181.1_1 - 8.3e-15 54.3 2.2 1.5e-14 53.5 2.2 1.3 1 0 0 1 1 1 1 Heat shock factor binding protein 1 7tm_4 PF13853.4 NM_146807.1_1 - 7.4e-48 163.5 17.5 9.1e-48 163.3 17.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146807.1_1 - 1.2e-24 86.8 19.1 2.4e-24 85.9 19.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146807.1_1 - 0.0031 16.8 19.4 0.0066 15.7 19.3 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_146807.1_1 - 1 8.5 16.3 3.8 6.6 16.3 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx CH PF00307.29 NM_153406.3_2 - 3.4e-20 72.1 0.1 9.7e-20 70.7 0.1 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 NM_153406.3_2 - 0.00037 20.1 0.0 0.0008 19.1 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain Baculo_PEP_C PF04513.10 NM_153406.3_2 - 4.4 7.2 26.9 0.27 11.1 1.4 5.2 3 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.10 NM_153406.3_2 - 5.7 6.9 86.2 0.033 14.1 14.0 6.0 5 1 0 5 5 5 0 TPR/MLP1/MLP2-like protein ENTH PF01417.18 NM_027984.3_2 - 1e-49 167.6 0.0 1.6e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.14 NM_027984.3_2 - 3.4e-05 22.8 0.0 5e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 ANTH domain UIM PF02809.18 NM_027984.3_2 - 3.9e-05 23.2 17.9 0.0095 15.7 2.8 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif VHS PF00790.17 NM_027984.3_2 - 0.039 13.7 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 VHS domain Glyco_transf_6 PF03414.11 NM_001308300.1_1 - 6.3e-160 531.1 4.0 8.5e-160 530.6 4.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 6 DUF4629 PF15442.4 NM_177890.3_1 - 1.6e-60 203.6 12.2 1.6e-60 203.6 12.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4629) PPP1R32 PF15691.3 NM_133689.1_2 - 4.4e-196 651.9 9.5 5e-196 651.7 9.5 1.0 1 0 0 1 1 1 1 Protein phosphatase 1 regulatory subunit 32 Pkinase PF00069.23 NM_010633.3_1 - 1.9e-38 132.2 0.0 2.5e-38 131.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_010633.3_1 - 2.8e-20 72.6 0.0 3.9e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.20 NM_010633.3_1 - 1.1e-06 28.2 0.0 2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinase-like PF14531.4 NM_010633.3_1 - 3.7e-06 26.3 0.0 5.2e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_010633.3_1 - 8.7e-05 21.8 0.0 0.00016 21.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_010633.3_1 - 0.00084 19.2 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.20 NM_010633.3_1 - 0.0064 16.0 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Tmemb_9 PF05434.9 NM_025439.3_3 - 5e-54 182.0 0.1 7.1e-54 181.5 0.1 1.2 1 0 0 1 1 1 1 TMEM9 Defensin_propep PF00879.16 NM_001012640.2_3 - 4.9e-21 74.7 0.3 6.3e-21 74.3 0.3 1.1 1 0 0 1 1 1 1 Defensin propeptide DUF544 PF04424.11 NM_199475.1_2 - 2.2e-38 130.7 0.0 3.9e-38 129.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF544) DUF371 PF04027.11 NM_199475.1_2 - 0.034 14.0 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF371) DUF4519 PF15012.4 NM_001277893.1_2 - 0.39 10.8 1.0 0.65 10.1 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) FKBP_C PF00254.26 NM_001277893.1_3 - 8.9e-18 64.3 0.0 1.4e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.15 NM_001277893.1_3 - 6.6e-07 28.8 4.0 0.014 15.4 0.1 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001277893.1_3 - 5.7e-05 23.2 4.1 0.0012 18.9 0.9 1.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001277893.1_3 - 0.0069 16.7 0.6 0.013 15.9 0.6 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001277893.1_3 - 0.018 14.7 0.7 2 8.2 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001277893.1_3 - 0.056 13.6 0.2 7.7 6.9 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_001277893.1_3 - 0.13 12.3 1.7 1.7 8.7 0.2 2.2 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Pkinase_Tyr PF07714.15 NM_172821.3_1 - 5.5e-64 215.8 0.0 7.5e-64 215.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_172821.3_1 - 3.2e-59 200.3 0.0 4.8e-59 199.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF737 PF05300.9 NM_172821.3_1 - 1 9.5 6.1 0.062 13.5 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF737) CARMIL_C PF16000.3 NM_001033320.2_2 - 4.4e-62 210.3 0.1 3.2e-61 207.5 0.0 2.2 2 0 0 2 2 2 1 CARMIL C-terminus Homeobox PF00046.27 NM_001205274.1_2 - 1.7e-10 40.4 1.0 1.7e-10 40.4 1.0 1.8 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 NM_001205274.1_2 - 0.00093 18.9 0.5 0.0019 17.9 0.1 1.7 2 0 0 2 2 2 1 Homeobox KN domain Slx4 PF09494.8 NM_177472.5_3 - 7.6e-15 54.5 0.0 1.5e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Slx4 endonuclease BTB PF00651.29 NM_177472.5_3 - 1.5e-13 50.8 0.0 2.8e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain LRR_9 PF14580.4 NM_001162973.1_1 - 2.3e-12 46.6 0.0 2e-11 43.6 0.0 2.0 1 1 1 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.4 NM_001162973.1_1 - 1.3e-06 28.0 11.9 6e-06 25.8 1.3 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 NM_001162973.1_1 - 2.9e-06 27.4 2.9 0.00081 19.6 0.1 3.4 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001162973.1_1 - 4.6 8.0 7.2 99 3.9 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat zf-H2C2_2 PF13465.4 NM_001081382.1_1 - 6.7e-50 165.3 73.4 2.2e-08 34.0 2.8 11.2 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001081382.1_1 - 1.9e-38 128.6 90.5 1.2e-06 28.5 2.9 9.5 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001081382.1_1 - 1.1e-20 72.4 83.8 0.00015 22.1 2.3 9.6 9 0 0 9 9 9 8 C2H2-type zinc finger KRAB PF01352.25 NM_001081382.1_1 - 1.1e-19 69.7 0.5 2.8e-19 68.4 0.5 1.7 1 0 0 1 1 1 1 KRAB box DUF3669 PF12417.6 NM_001081382.1_1 - 4.3e-09 36.3 0.1 1.2e-08 34.9 0.1 1.8 1 0 0 1 1 1 1 Zinc finger protein zf-C2H2_6 PF13912.4 NM_001081382.1_1 - 2.3e-08 33.6 63.3 0.45 10.4 1.3 9.6 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001081382.1_1 - 7.3e-06 26.0 52.3 0.15 12.2 0.2 9.7 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding DZR PF12773.5 NM_001081382.1_1 - 0.00085 19.2 36.1 0.2 11.6 2.6 5.2 3 2 1 4 4 4 4 Double zinc ribbon zf-met PF12874.5 NM_001081382.1_1 - 0.00096 19.3 0.9 0.00096 19.3 0.9 9.2 10 0 0 10 10 10 2 Zinc-finger of C2H2 type CpXC PF14353.4 NM_001081382.1_1 - 0.0012 18.8 33.8 0.41 10.6 1.7 8.6 5 2 2 7 7 7 3 CpXC protein Zn-ribbon_8 PF09723.8 NM_001081382.1_1 - 0.003 17.5 43.1 0.21 11.6 2.5 5.9 4 2 1 5 5 5 4 Zinc ribbon domain C1_4 PF07975.10 NM_001081382.1_1 - 0.01 15.9 1.3 0.01 15.9 1.3 5.4 4 1 1 5 5 5 0 TFIIH C1-like domain DUF3268 PF11672.6 NM_001081382.1_1 - 0.094 12.9 16.5 5.7 7.2 0.1 4.7 4 1 1 5 5 5 0 zinc-finger-containing domain ADK_lid PF05191.12 NM_001081382.1_1 - 0.3 11.0 17.5 3.4 7.6 0.1 5.8 3 1 2 5 5 5 0 Adenylate kinase, active site lid PRP38 PF03371.13 NM_172697.3_1 - 4e-61 205.8 0.9 5.2e-61 205.4 0.9 1.1 1 0 0 1 1 1 1 PRP38 family PRP38_assoc PF12871.5 NM_172697.3_1 - 6.3e-07 29.7 38.1 6.3e-07 29.7 38.1 2.2 1 1 1 2 2 2 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF2457 PF10446.7 NM_172697.3_1 - 0.75 8.8 34.1 1.3 8.0 34.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Hyd_WA PF06462.10 NM_027410.1_2 - 3.5e-68 225.1 61.1 7.9e-12 44.8 1.8 10.6 12 0 0 12 12 12 8 Propeller Pex24p PF06398.9 NM_027410.1_2 - 1.7e-18 66.6 18.3 1.3e-09 37.3 3.2 2.2 2 0 0 2 2 2 2 Integral peroxisomal membrane peroxin PH PF00169.27 NM_027410.1_2 - 0.0033 17.8 0.1 0.01 16.2 0.0 1.8 2 0 0 2 2 2 1 PH domain Macro PF01661.19 NM_001039530.3_3 - 5.1e-62 207.0 6.1 2.8e-32 111.1 0.2 4.0 4 0 0 4 4 4 3 Macro domain PARP PF00644.18 NM_001039530.3_3 - 2.5e-27 95.7 2.4 1.3e-26 93.4 2.4 2.2 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SLS PF14611.4 NM_001039530.3_3 - 0.007 16.1 11.0 3.2 7.4 0.0 4.5 4 1 1 5 5 5 3 Mitochondrial inner-membrane-bound regulator WWE PF02825.18 NM_001039530.3_3 - 0.029 14.8 0.3 0.14 12.6 0.3 2.2 1 0 0 1 1 1 0 WWE domain Nudix_N PF12535.6 NM_001039530.3_3 - 0.16 11.5 0.0 0.41 10.1 0.0 1.7 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal MEA1 PF06910.9 NM_001277312.1_3 - 7.8e-109 360.9 10.0 9.8e-109 360.5 10.0 1.1 1 0 0 1 1 1 1 Male enhanced antigen 1 (MEA1) RRM_1 PF00076.20 NM_001166410.2_1 - 3.4e-24 84.3 0.0 5.3e-24 83.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001166410.2_1 - 0.0025 17.8 0.0 0.005 16.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif 6PGD PF00393.17 NM_001081274.1_3 - 3.8e-131 436.6 0.0 4.9e-131 436.2 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.13 NM_001081274.1_3 - 1.7e-49 167.9 0.0 2.7e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.4 NM_001081274.1_3 - 0.016 15.3 0.1 0.062 13.4 0.0 2.0 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.15 NM_001081274.1_3 - 0.082 13.4 0.1 0.19 12.2 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Mcl1_mid PF12341.6 NM_172598.3_3 - 4.5e-100 334.6 0.0 1.7e-99 332.7 0.0 2.0 3 0 0 3 3 3 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.30 NM_172598.3_3 - 2.6e-18 65.9 8.3 3.4e-08 33.9 0.1 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_172598.3_3 - 3.5e-11 43.1 0.5 6.4e-05 23.0 0.1 3.8 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain HMG_box PF00505.17 NM_172598.3_3 - 4e-06 27.0 0.2 8.7e-06 25.9 0.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box eIF2A PF08662.9 NM_172598.3_3 - 0.0001 22.1 0.7 0.0016 18.2 0.0 2.5 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.4 NM_172598.3_3 - 0.11 12.4 0.0 2.2 8.2 0.0 2.6 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Hira PF07569.9 NM_172598.3_3 - 0.75 9.3 4.7 6.2 6.4 0.0 2.8 3 0 0 3 3 3 0 TUP1-like enhancer of split FOP_dimer PF09398.8 NM_025345.2_3 - 6.1e-17 61.5 0.2 1e-16 60.8 0.2 1.3 1 0 0 1 1 1 1 FOP N terminal dimerisation domain LisH_2 PF16045.3 NM_025345.2_3 - 2.5e-05 23.1 0.0 4.3e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 LisH DUF4505 PF14956.4 NM_145472.2_3 - 1.8e-79 265.5 0.0 2.3e-79 265.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4505) Tom37 PF10568.7 NM_016804.4_1 - 5.7e-29 100.9 0.0 1e-28 100.1 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.2 NM_016804.4_1 - 2.1e-24 86.0 0.0 4.1e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.2 NM_016804.4_1 - 5.3e-24 83.7 0.1 1.1e-23 82.7 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 NM_016804.4_1 - 1.1e-05 25.1 0.0 2.4e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TRADD_N PF09034.8 NM_016804.4_1 - 0.038 13.9 0.0 0.094 12.6 0.0 1.6 1 0 0 1 1 1 0 TRADD, N-terminal domain GST_C_3 PF14497.4 NM_016804.4_1 - 0.063 13.3 0.2 0.17 11.9 0.1 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Thyroglobulin_1 PF00086.16 NM_022316.2_1 - 4.1e-37 125.5 14.9 2.1e-18 65.6 5.0 2.7 2 0 0 2 2 2 2 Thyroglobulin type-1 repeat Thyroglob_assoc PF16597.3 NM_022316.2_1 - 1.2e-23 83.0 0.7 2.3e-23 82.1 0.7 1.5 1 0 0 1 1 1 1 Thyroglobulin_1 repeat associated disordered domain SPARC_Ca_bdg PF10591.7 NM_022316.2_1 - 3.2e-08 33.8 0.0 6e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_2 PF07648.13 NM_022316.2_1 - 6.3e-07 29.4 1.4 6.3e-07 29.4 1.4 2.9 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.4 NM_022316.2_1 - 0.0022 18.3 0.0 0.004 17.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair Kazal_1 PF00050.19 NM_022316.2_1 - 0.012 15.4 2.7 0.012 15.4 2.7 3.0 3 0 0 3 3 3 0 Kazal-type serine protease inhibitor domain Sec7 PF01369.18 NM_015791.3_3 - 3.1e-35 121.4 0.1 4.7e-35 120.8 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain F-box-like PF12937.5 NM_015791.3_3 - 1.8e-06 27.6 0.5 4.5e-06 26.3 0.5 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_015791.3_3 - 0.015 15.0 0.8 0.04 13.7 0.1 2.1 2 0 0 2 2 2 0 F-box domain Myosin_head PF00063.19 NM_001039545.2_3 - 8.4e-287 952.8 7.4 8.4e-287 952.8 7.4 3.4 3 1 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 NM_001039545.2_3 - 2.1e-163 545.6 266.4 2.6e-163 545.3 266.4 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 NM_001039545.2_3 - 1.1e-12 47.4 2.0 3.1e-12 45.9 2.0 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 NM_001039545.2_3 - 3.5e-06 26.5 67.8 0.024 13.9 1.4 9.1 1 1 8 10 10 10 9 Reovirus sigma C capsid protein TSNAXIP1_N PF15739.3 NM_001039545.2_3 - 0.0024 18.1 7.8 0.0024 18.1 7.8 15.0 3 3 11 16 16 16 2 Translin-associated factor X-interacting N-terminus IQ PF00612.25 NM_001039545.2_3 - 0.0036 16.8 1.9 0.02 14.5 0.3 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif AAA_22 PF13401.4 NM_001039545.2_3 - 0.11 12.7 0.0 0.11 12.7 0.0 5.8 4 2 1 5 5 5 0 AAA domain AAA_16 PF13191.4 NM_001039545.2_3 - 0.47 10.7 0.0 0.47 10.7 0.0 6.2 3 2 0 5 5 5 0 AAA ATPase domain CUE PF02845.14 NM_007517.4_2 - 2e-09 36.8 0.0 4.4e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 CUE domain 4HBT PF03061.20 NM_001146057.1_2 - 1e-31 108.9 5.8 3.8e-16 59.1 0.3 2.7 3 0 0 3 3 3 2 Thioesterase superfamily NINJA_B PF16136.3 NM_001146057.1_2 - 0.0027 17.9 0.3 0.0027 17.9 0.3 2.4 3 0 0 3 3 3 1 Putative nuclear localisation signal tRNA_anti-codon PF01336.23 NM_001146057.1_2 - 0.0031 17.4 0.0 0.025 14.4 0.0 2.3 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain TBCC PF07986.10 NM_001146057.1_2 - 0.19 11.4 2.6 1.2 8.8 0.1 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor C CH_2 PF06294.9 NM_027641.2_3 - 3.1e-32 110.4 0.0 5.5e-32 109.6 0.0 1.4 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.6 NM_027641.2_3 - 3.9e-14 52.1 0.0 6.6e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.29 NM_027641.2_3 - 0.043 13.9 0.0 0.084 12.9 0.0 1.4 1 0 0 1 1 1 0 Calponin homology (CH) domain DUF641 PF04859.10 NM_027641.2_3 - 0.13 12.5 1.6 0.22 11.7 1.6 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) 7tm_1 PF00001.19 NM_198192.2_1 - 9.7e-55 185.5 17.8 1.2e-54 185.2 17.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_198192.2_1 - 1e-05 25.0 20.1 1.6e-05 24.3 20.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx T4SS_CagC PF16943.3 NM_198192.2_1 - 0.042 13.9 0.1 0.042 13.9 0.1 2.1 2 1 0 2 2 2 0 Cag pathogenicity island, type IV secretory system Herpes_US9 PF06072.9 NM_198192.2_1 - 0.51 10.1 2.7 0.56 10.0 0.4 2.3 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 ERM PF00769.17 NM_001104616.1_3 - 1e-74 251.3 52.1 1e-74 251.3 52.1 2.3 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_M PF00373.16 NM_001104616.1_3 - 2.1e-28 99.0 1.2 2.1e-28 99.0 1.2 3.0 3 1 0 3 3 3 1 FERM central domain FERM_C PF09380.8 NM_001104616.1_3 - 1.4e-27 95.8 0.0 4.1e-27 94.3 0.0 1.9 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_001104616.1_3 - 2e-14 53.2 1.1 4.3e-14 52.1 0.1 2.1 2 0 0 2 2 2 1 FERM N-terminal domain 7tm_4 PF13853.4 NM_146481.2_1 - 6.2e-48 163.8 24.3 8e-48 163.4 24.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146481.2_1 - 1.8e-24 86.3 23.6 3.2e-24 85.5 23.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146481.2_1 - 0.0026 17.1 25.0 0.004 16.4 25.0 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx RGS PF00615.17 NM_001291210.1_2 - 3.9e-34 117.3 0.1 5.3e-34 116.9 0.1 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Latrophilin PF02354.14 NM_198702.2_1 - 8e-117 390.3 20.3 1.7e-85 287.2 4.2 2.2 1 1 1 2 2 2 2 Latrophilin Cytoplasmic C-terminal region OLF PF02191.14 NM_198702.2_1 - 5.3e-84 281.5 5.1 9.1e-84 280.8 5.1 1.4 1 0 0 1 1 1 1 Olfactomedin-like domain 7tm_2 PF00002.22 NM_198702.2_1 - 1.2e-69 234.2 19.3 1.7e-69 233.7 19.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.3 NM_198702.2_1 - 1.4e-54 184.6 2.9 2.1e-54 184.0 2.9 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.16 NM_198702.2_1 - 2.2e-23 82.4 0.7 2.2e-23 82.4 0.7 2.0 2 0 0 2 2 2 1 Galactose binding lectin domain GPS PF01825.19 NM_198702.2_1 - 5.3e-15 55.7 6.7 1.6e-14 54.2 6.7 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 NM_198702.2_1 - 4e-06 26.9 0.5 1.2e-05 25.4 0.5 1.9 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.9 NM_198702.2_1 - 0.00051 19.1 10.9 0.00097 18.2 10.9 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Pox_A14 PF05767.10 NM_198702.2_1 - 1.9 8.6 5.0 3.4 7.7 1.7 2.6 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 PSI PF01437.23 NM_028199.3_2 - 0.00019 21.8 15.2 0.00019 21.8 15.2 2.6 2 0 0 2 2 2 1 Plexin repeat MGC-24 PF05283.9 NM_028199.3_2 - 0.0032 17.8 0.8 0.0032 17.8 0.8 1.7 2 0 0 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin Gla PF00594.18 NM_001303028.1_1 - 6.4e-19 67.7 9.2 1.2e-18 66.9 9.2 1.5 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Ank_2 PF12796.5 NM_175270.4_3 - 6.1e-09 36.2 0.0 1.2e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 NM_175270.4_3 - 2.4e-08 33.9 0.9 1.7e-05 24.9 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 NM_175270.4_3 - 7e-08 32.5 0.2 4.1e-06 26.9 0.0 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_175270.4_3 - 2.5e-06 27.8 0.1 6e-06 26.6 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_175270.4_3 - 3.5e-05 23.7 0.3 0.076 13.5 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeat 7tm_4 PF13853.4 NM_146533.1_1 - 7.3e-54 183.2 9.4 9.1e-54 182.9 9.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146533.1_1 - 4.8e-25 88.2 16.0 1.2e-24 86.9 16.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146533.1_1 - 6.4e-06 25.6 5.9 6.4e-06 25.6 5.9 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx HAUS2 PF15003.4 NM_001290807.1_2 - 1.8e-63 213.6 5.5 2.5e-63 213.1 5.5 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 Wtap PF17098.3 NM_001290807.1_2 - 0.055 13.3 2.4 0.056 13.3 0.1 2.0 3 0 0 3 3 3 0 WTAP/Mum2p family SH3_9 PF14604.4 NM_001159510.1_2 - 1.8e-16 59.6 0.3 9.8e-15 54.0 0.3 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 NM_001159510.1_2 - 1.2e-15 56.6 0.1 2.7e-15 55.6 0.1 1.6 1 0 0 1 1 1 1 SH3 domain FCH PF00611.21 NM_001159510.1_2 - 2.3e-15 56.5 0.2 2.3e-15 56.5 0.2 2.4 3 1 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.15 NM_001159510.1_2 - 4.8e-07 29.2 0.0 1.1e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain NPF PF16601.3 NM_001159510.1_2 - 9.4e-05 22.8 4.5 9.4e-05 22.8 4.5 1.6 2 0 0 2 2 2 1 Rabosyn-5 repeating NPF sequence-motif Exonuc_VII_L PF02601.13 NM_001159510.1_2 - 0.17 11.3 5.7 5.4 6.3 5.7 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit VGCC_alpha2 PF08473.9 NM_001110846.1_3 - 4.9e-214 710.8 1.1 6.8e-214 710.4 1.1 1.2 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.9 NM_001110846.1_3 - 5.1e-39 133.4 0.1 1e-38 132.4 0.1 1.5 1 0 0 1 1 1 1 VWA N-terminal VWA PF00092.26 NM_001110846.1_3 - 1.1e-20 74.5 0.8 1.7e-20 73.8 0.8 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 NM_001110846.1_3 - 5.4e-15 55.5 0.0 8.2e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.16 NM_001110846.1_3 - 2.5e-11 43.7 9.7 4.2e-10 39.7 0.1 3.6 4 0 0 4 4 4 2 Cache domain VWA_2 PF13519.4 NM_001110846.1_3 - 4.9e-10 39.9 0.9 1e-09 38.9 0.4 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain Cache_3-Cache_2 PF17201.2 NM_001110846.1_3 - 0.0067 15.6 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain SLAC1 PF03595.15 NM_001195189.1_3 - 0.053 12.7 2.4 1.5 8.0 0.4 2.1 2 0 0 2 2 2 0 Voltage-dependent anion channel Cytochrom_C_asm PF01578.18 NM_001195189.1_3 - 0.13 11.9 6.3 0.15 11.7 0.1 2.5 3 0 0 3 3 3 0 Cytochrome C assembly protein SelK_SelG PF10961.6 NM_001195189.1_3 - 0.14 12.7 0.4 0.14 12.7 0.4 2.6 3 0 0 3 3 3 0 Selenoprotein SelK_SelG SieB PF14163.4 NM_001195189.1_3 - 3.6 6.9 7.4 5.8 6.3 0.1 3.0 3 0 0 3 3 3 0 Super-infection exclusion protein B PKD_channel PF08016.10 NM_053177.1_1 - 5.4e-10 38.4 13.1 8.2e-10 37.8 13.1 1.2 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.29 NM_053177.1_1 - 0.035 13.2 22.1 0.093 11.8 22.2 1.6 1 1 0 1 1 1 0 Ion transport protein DUF1866 PF08952.9 NM_053177.1_1 - 0.042 13.6 0.4 0.73 9.5 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) G-gamma PF00631.20 NM_022422.5_3 - 8.9e-14 51.1 0.2 1.2e-13 50.7 0.2 1.2 1 0 0 1 1 1 1 GGL domain Pkinase PF00069.23 NM_001200041.1_2 - 2e-28 99.4 0.0 2.8e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001200041.1_2 - 2.4e-15 56.4 0.0 3.6e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001200041.1_2 - 0.00011 21.4 0.0 0.00018 20.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.9 NM_001200041.1_2 - 0.11 11.3 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.12 NM_001200041.1_2 - 0.21 10.8 0.0 0.35 10.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M14 PF00246.22 NM_023328.3_3 - 1.3e-11 44.8 0.0 2.2e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase V-ATPase_H_N PF03224.12 NM_023328.3_3 - 0.0011 18.2 0.2 0.0031 16.7 0.2 1.7 1 1 0 1 1 1 1 V-ATPase subunit H AstE_AspA PF04952.12 NM_023328.3_3 - 0.0012 17.9 0.0 0.002 17.1 0.0 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family RIX1 PF08167.10 NM_023328.3_3 - 0.14 11.8 2.2 0.24 11.0 0.7 2.0 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis Ig_3 PF13927.4 NM_007727.2_1 - 7.5e-70 231.4 0.0 1e-11 45.1 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 NM_007727.2_1 - 7.1e-59 195.7 0.1 3.5e-12 46.1 0.0 7.7 7 1 0 7 7 7 6 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_007727.2_1 - 1.9e-45 153.0 0.1 1.2e-08 35.0 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 NM_007727.2_1 - 3.7e-43 145.5 0.0 1.6e-09 37.7 0.0 7.3 6 1 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.19 NM_007727.2_1 - 4.6e-40 135.7 6.0 3.1e-13 49.7 0.0 4.6 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.15 NM_007727.2_1 - 4.1e-22 78.3 6.6 0.01 15.9 0.0 9.8 6 4 3 9 9 9 5 Immunoglobulin V-set domain Ig_4 PF16680.3 NM_007727.2_1 - 2.9e-07 30.6 0.2 1.1 9.5 0.0 5.5 6 0 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain Pur_ac_phosph_N PF16656.3 NM_007727.2_1 - 1.5e-06 28.6 0.7 0.0046 17.4 0.1 2.9 3 0 0 3 3 2 2 Purple acid Phosphatase, N-terminal domain Izumo-Ig PF16706.3 NM_007727.2_1 - 1.1e-05 25.2 0.0 5.4 7.0 0.0 5.5 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 NM_007727.2_1 - 0.0018 18.2 0.0 0.77 9.7 0.0 2.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Tissue_fac PF01108.15 NM_007727.2_1 - 0.056 13.1 0.1 4.2 7.1 0.0 3.5 4 0 0 4 4 4 0 Tissue factor Big_3_4 PF13754.4 NM_007727.2_1 - 0.083 12.5 0.2 0.33 10.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function Pkinase PF00069.23 NM_001113389.1_3 - 3.3e-49 167.5 0.0 4.5e-49 167.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001113389.1_3 - 3.6e-21 75.5 0.0 5.4e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase G-patch PF01585.21 NM_001128597.1_3 - 3.4e-13 49.1 0.5 7.4e-13 48.1 0.5 1.6 1 0 0 1 1 1 1 G-patch domain Ank_2 PF12796.5 NM_001128597.1_3 - 6.2e-06 26.6 0.0 1e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_001128597.1_3 - 8.3e-05 22.7 0.8 0.0032 17.7 0.7 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_001128597.1_3 - 0.00012 22.4 0.0 0.00025 21.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001128597.1_3 - 0.00031 20.8 0.0 0.0066 16.7 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat G-patch_2 PF12656.5 NM_001128597.1_3 - 0.08 12.9 0.2 0.24 11.4 0.2 1.8 1 0 0 1 1 1 0 G-patch domain SPT6_acidic PF14632.4 NM_001128597.1_3 - 0.22 12.0 1.7 0.23 12.0 0.1 1.7 2 0 0 2 2 2 0 Acidic N-terminal SPT6 zf-DBF PF07535.10 NM_001128597.1_3 - 0.28 11.2 1.1 0.44 10.5 1.1 1.2 1 0 0 1 1 1 0 DBF zinc finger ETC_C1_NDUFA4 PF04800.10 NM_010887.2_3 - 2.7e-38 130.0 2.1 4.1e-38 129.4 2.1 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region NDUF_B5 PF09781.7 NM_025316.2_2 - 5.3e-87 290.1 0.0 6.2e-87 289.9 0.0 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit DUF3749 PF12568.6 NM_025316.2_2 - 0.064 12.9 0.0 2.6 7.7 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain V-set PF07686.15 NM_001039149.1_3 - 1.8e-08 34.4 0.1 2.9e-08 33.7 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001039149.1_3 - 3.1e-07 30.8 0.2 6.1e-07 29.8 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 NM_001039149.1_3 - 0.00047 20.0 0.0 0.00096 19.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001039149.1_3 - 0.00051 20.2 0.2 0.0022 18.2 0.2 2.0 1 1 0 1 1 1 1 Immunoglobulin domain stn_TNFRSF12A PF12191.6 NM_001039149.1_3 - 0.0099 16.0 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain TMEM154 PF15102.4 NM_001039149.1_3 - 0.026 14.3 0.8 0.045 13.5 0.8 1.3 1 0 0 1 1 1 0 TMEM154 protein family ig PF00047.23 NM_001039149.1_3 - 0.029 14.4 0.1 0.093 12.8 0.1 1.8 1 1 0 1 1 1 0 Immunoglobulin domain LAX PF15681.3 NM_001039149.1_3 - 0.036 12.6 0.1 0.058 11.9 0.1 1.2 1 0 0 1 1 1 0 Lymphocyte activation family X Syndecan PF01034.18 NM_001039149.1_3 - 0.1 12.4 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Syndecan domain Adeno_E3_CR2 PF02439.13 NM_001039149.1_3 - 0.16 11.7 1.5 0.33 10.6 1.5 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Lamp PF01299.15 NM_001039149.1_3 - 0.27 10.6 2.3 0.42 10.0 2.3 1.2 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) SMN PF06003.10 NM_172429.2_3 - 3.4e-15 55.9 1.4 3.4e-15 55.9 1.4 2.1 2 0 0 2 2 2 1 Survival motor neuron protein (SMN) TUDOR PF00567.22 NM_172429.2_3 - 0.0068 16.3 0.0 0.018 15.0 0.0 1.7 2 0 0 2 2 2 1 Tudor domain PWWP PF00855.15 NM_001025383.2_1 - 2.4e-06 27.8 0.0 0.044 14.1 0.1 2.7 2 0 0 2 2 2 2 PWWP domain FAM27 PF15832.3 NM_011415.2_1 - 0.00092 19.6 12.8 0.00092 19.6 12.8 2.4 3 0 0 3 3 3 1 FAM27 D and E protein family zf-C2H2 PF00096.24 NM_011415.2_2 - 6.6e-18 64.0 58.1 8.3e-06 25.8 1.3 6.6 7 0 0 7 7 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_011415.2_2 - 3.7e-17 61.4 38.4 0.00015 22.2 1.1 6.5 6 0 0 6 6 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_011415.2_2 - 2.1e-15 56.2 38.2 1.8e-07 31.2 0.5 6.6 6 0 0 6 6 5 4 Zinc-finger double domain zf-C2H2_6 PF13912.4 NM_011415.2_2 - 4.9e-09 35.8 32.7 0.0082 15.9 0.7 6.1 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_011415.2_2 - 3.7e-08 33.4 35.9 0.0013 18.9 0.1 6.5 7 0 0 7 7 6 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 NM_011415.2_2 - 2.8e-06 27.4 17.1 0.016 15.3 3.0 4.0 3 0 0 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding FAM27 PF15832.3 NM_011415.2_2 - 0.0007 19.9 18.1 0.0007 19.9 18.1 2.7 2 0 0 2 2 1 1 FAM27 D and E protein family zf-BED PF02892.13 NM_011415.2_2 - 0.00088 19.1 25.3 0.97 9.4 0.3 5.7 2 1 2 5 5 5 4 BED zinc finger zf-met PF12874.5 NM_011415.2_2 - 0.0029 17.8 2.1 0.014 15.6 0.7 6.5 7 0 0 7 7 5 4 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 NM_011415.2_2 - 0.027 15.1 1.2 0.027 15.1 1.2 3.6 4 1 0 4 4 2 0 zinc-ribbon family zf-C2HC_2 PF13913.4 NM_011415.2_2 - 0.051 13.4 19.1 2.9 7.8 1.1 5.1 5 0 0 5 5 5 0 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.8 NM_011415.2_2 - 1.6 8.8 21.4 1.6 8.8 2.1 4.4 3 1 1 4 4 4 0 Zinc ribbon domain ASH PF15780.3 NM_027556.1_1 - 1.9e-17 63.1 1.0 1.4e-05 25.1 0.0 7.3 6 2 0 6 6 6 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.6 NM_027556.1_1 - 1.4e-09 37.8 0.6 0.17 11.9 0.0 5.8 5 1 0 5 5 5 3 Transmembrane protein 131-like MYCBPAP PF14646.4 NM_027556.1_1 - 1.6e-08 33.8 0.0 0.00093 18.1 0.0 4.2 4 0 0 4 4 4 3 MYCBP-associated protein family Motile_Sperm PF00635.24 NM_027556.1_1 - 0.0047 16.6 0.1 1 9.1 0.0 4.4 4 0 0 4 4 4 1 MSP (Major sperm protein) domain WD40 PF00400.30 NM_028112.2_3 - 7.9e-13 48.6 33.3 0.00027 21.5 1.9 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_028112.2_3 - 8e-07 29.1 7.0 0.04 14.1 0.2 3.6 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 NM_028112.2_3 - 3.1e-06 26.2 1.4 0.45 9.3 0.0 3.3 3 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Apo-CIII PF05778.10 NM_001289755.1_3 - 2e-34 116.9 0.2 2.9e-34 116.4 0.2 1.2 1 0 0 1 1 1 1 Apolipoprotein CIII (Apo-CIII) TIG PF01833.22 NM_153179.3_2 - 2.9e-63 209.8 30.2 7.1e-09 35.5 0.1 14.1 13 2 1 14 14 14 10 IPT/TIG domain G8 PF10162.7 NM_153179.3_2 - 3.4e-54 182.0 0.0 5.6e-29 100.6 0.0 3.3 3 0 0 3 3 3 2 G8 domain Beta_helix PF13229.4 NM_153179.3_2 - 5.4e-19 68.5 14.4 7.7e-08 32.2 0.0 4.0 4 1 1 5 5 5 3 Right handed beta helix region NosD PF05048.11 NM_153179.3_2 - 1.2e-06 27.9 13.5 0.00075 18.7 2.8 4.0 3 1 1 4 4 4 3 Periplasmic copper-binding protein (NosD) PA14 PF07691.10 NM_153179.3_2 - 0.014 15.1 0.0 0.037 13.7 0.0 1.7 1 0 0 1 1 1 0 PA14 domain Glyco_transf_7N PF13733.4 NM_017377.5_2 - 6.5e-56 187.5 0.0 1e-55 186.9 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 NM_017377.5_2 - 1.1e-30 104.9 0.3 2.2e-30 104.0 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 NM_017377.5_2 - 0.0072 15.7 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 COX6B PF02297.15 NM_001289848.1_2 - 1.9e-17 63.1 3.8 2.7e-17 62.6 3.8 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.3 NM_001289848.1_2 - 0.024 14.5 1.4 0.045 13.6 1.4 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, BTG PF07742.10 NM_009770.3_1 - 5.1e-43 145.5 0.1 8.1e-43 144.8 0.1 1.3 1 0 0 1 1 1 1 BTG family SRI PF08236.9 NM_009770.3_1 - 0.093 12.8 2.6 0.067 13.2 1.0 1.6 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain Resistin PF06954.9 NM_022984.4_1 - 6.7e-35 119.4 12.2 1.3e-34 118.5 12.2 1.5 1 0 0 1 1 1 1 Resistin zf-C2H2 PF00096.24 NM_001081473.1_2 - 3.6e-28 96.3 73.6 9.3e-05 22.5 0.9 11.3 11 0 0 11 11 11 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001081473.1_2 - 1.5e-19 69.3 54.4 0.00023 21.3 0.4 9.9 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001081473.1_2 - 3.1e-14 52.3 93.5 0.0025 18.4 0.7 11.6 12 0 0 12 12 12 9 C2H2-type zinc finger zf-C2H2_8 PF15909.3 NM_001081473.1_2 - 2.5e-08 34.0 30.3 0.0012 19.0 5.5 6.0 1 1 6 7 7 7 6 C2H2-type zinc ribbon zf-C2H2_6 PF13912.4 NM_001081473.1_2 - 2.2e-06 27.4 30.3 0.012 15.4 0.5 6.6 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_aberr PF17017.3 NM_001081473.1_2 - 7.8e-05 22.7 28.3 2.9 7.9 0.8 7.1 1 1 4 7 7 7 5 Aberrant zinc-finger FOXP-CC PF16159.3 NM_001081473.1_2 - 0.035 14.6 0.2 0.035 14.6 0.2 5.3 5 1 1 6 6 6 0 FOXP coiled-coil domain zf-C2H2_11 PF16622.3 NM_001081473.1_2 - 8.1 6.2 19.0 4.8 6.9 0.4 6.0 6 0 0 6 6 6 0 zinc-finger C2H2-type C2 PF00168.28 NM_001256382.1_3 - 9.7e-37 125.3 0.0 4.7e-19 68.5 0.0 2.6 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 NM_001256382.1_3 - 5.6e-15 55.5 13.2 1.2e-14 54.4 13.2 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger PDZ PF00595.22 NM_001256382.1_3 - 1.1e-05 25.5 0.0 2.3e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Copine PF07002.14 NM_025815.2_1 - 2.7e-88 295.0 0.0 3.6e-88 294.5 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.28 NM_025815.2_1 - 1.6e-29 102.0 0.1 3.5e-14 52.8 0.0 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 NM_025815.2_1 - 7.3e-06 26.1 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VCBS PF13517.4 NM_025815.2_1 - 0.17 12.4 0.2 0.44 11.0 0.2 1.7 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Pkinase PF00069.23 NM_001253888.1_1 - 1e-58 198.7 0.0 1.4e-58 198.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001253888.1_1 - 2.3e-34 118.8 0.0 4.8e-34 117.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001253888.1_1 - 0.0069 15.6 0.1 0.18 10.9 0.0 2.7 3 0 0 3 3 3 1 Kinase-like Glyco_hydro_47 PF01532.18 NM_001029983.2_1 - 2.2e-163 544.3 0.0 2.7e-163 544.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Tetraspannin PF00335.18 NM_019634.2_1 - 1.8e-46 158.5 8.9 3.1e-46 157.7 8.9 1.3 1 0 0 1 1 1 1 Tetraspanin family A2M_comp PF07678.12 NM_001001179.3_2 - 1.8e-68 230.6 1.3 2.8e-68 229.9 1.3 1.3 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_N_2 PF07703.12 NM_001001179.3_2 - 2.1e-29 102.5 2.5 1.2e-26 93.6 0.0 4.5 4 2 0 4 4 4 1 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 NM_001001179.3_2 - 9.5e-25 86.1 1.5 9.5e-25 86.1 1.5 3.2 3 0 0 3 3 3 1 Alpha-2-macroglobulin family A2M_recep PF07677.12 NM_001001179.3_2 - 1.4e-18 67.3 1.6 3.9e-18 65.9 0.5 2.4 2 0 0 2 2 2 1 A-macroglobulin receptor A2M_N PF01835.17 NM_001001179.3_2 - 1.1e-14 54.5 0.1 4e-14 52.7 0.1 2.0 1 0 0 1 1 1 1 MG2 domain Thiol-ester_cl PF10569.7 NM_001001179.3_2 - 1.6e-14 53.2 0.6 4.4e-14 51.7 0.6 1.9 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region SVA PF05326.9 NM_001001179.3_2 - 0.037 13.9 0.9 0.26 11.2 0.9 2.6 1 0 0 1 1 1 0 Seminal vesicle autoantigen (SVA) Yae1_N PF09811.7 NM_027629.3_1 - 0.37 10.4 5.3 0.68 9.5 5.3 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal PGM_PMM_I PF02878.14 NM_027629.3_3 - 4e-33 113.9 0.0 6.4e-33 113.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.14 NM_027629.3_3 - 1.8e-23 83.0 0.0 4.3e-23 81.7 0.0 1.7 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.14 NM_027629.3_3 - 7.8e-13 48.5 0.0 1.3e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.18 NM_027629.3_3 - 1.8e-07 31.1 0.0 6.5e-06 26.1 0.0 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Yae1_N PF09811.7 NM_027629.3_3 - 0.68 9.5 7.2 1.5 8.5 7.2 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Thioredoxin PF00085.18 NM_172054.4_1 - 4.3e-09 36.1 0.0 7.8e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.14 NM_172054.4_1 - 0.0028 16.5 0.1 0.0045 15.8 0.1 1.2 1 0 0 1 1 1 1 Phosducin SAM_1 PF00536.28 NM_001290288.1_1 - 6.8e-13 48.7 0.0 1e-10 41.8 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 NM_001290288.1_1 - 2.5e-10 40.2 0.0 1.4e-09 37.8 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Taxilin PF09728.7 NM_001005506.3_1 - 1.1e-116 389.3 78.3 1.4e-116 389.0 78.3 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein FlaC_arch PF05377.9 NM_001005506.3_1 - 0.42 10.9 15.6 2.1 8.7 1.4 3.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Metallophos PF00149.26 NM_029837.1_2 - 2.6e-10 41.0 0.8 3.8e-10 40.5 0.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 NM_029837.1_2 - 0.013 15.6 0.0 0.13 12.3 0.0 2.1 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain DUF4504 PF14953.4 NM_001160359.1_1 - 1.4e-70 237.6 0.0 1.8e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4504) CLASP_N PF12348.6 NM_001114347.1_2 - 6e-52 176.3 11.1 3.6e-39 134.5 0.1 4.2 4 0 0 4 4 4 3 CLASP N terminal HEAT PF02985.20 NM_001114347.1_2 - 1.8e-13 49.3 9.5 0.0055 16.7 0.0 8.4 8 0 0 8 8 8 3 HEAT repeat HEAT_EZ PF13513.4 NM_001114347.1_2 - 2.8e-10 40.3 0.2 0.077 13.3 0.0 5.7 5 0 0 5 5 5 2 HEAT-like repeat Cnd1 PF12717.5 NM_001114347.1_2 - 6.9e-07 29.3 7.3 0.0066 16.3 0.7 5.3 4 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.7 NM_001114347.1_2 - 0.0001 22.3 2.7 0.059 13.4 0.2 3.8 3 1 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 TFCD_C PF12612.6 NM_001114347.1_2 - 0.0007 19.4 0.3 0.069 12.9 0.1 3.7 4 0 0 4 4 4 1 Tubulin folding cofactor D C terminal MMS19_N PF14500.4 NM_001114347.1_2 - 0.0043 16.5 4.0 10 5.5 0.1 3.7 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II Ipi1_N PF12333.6 NM_001114347.1_2 - 0.0079 16.7 0.9 1 9.9 0.0 3.5 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation TAN PF11640.6 NM_001114347.1_2 - 0.0088 16.1 2.2 0.16 12.0 0.1 3.8 3 1 1 4 4 4 1 Telomere-length maintenance and DNA damage repair Vac14_Fab1_bd PF12755.5 NM_001114347.1_2 - 0.015 15.7 1.9 42 4.7 0.0 5.3 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region ParcG PF10274.7 NM_001114347.1_2 - 0.021 14.8 0.8 0.099 12.6 0.1 2.5 3 0 0 3 3 3 0 Parkin co-regulated protein MMS19_C PF12460.6 NM_001114347.1_2 - 0.031 13.3 6.7 0.27 10.2 0.7 3.3 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal PhzC-PhzF PF02567.14 NM_026085.2_1 - 3.2e-60 203.9 0.0 4.1e-60 203.5 0.0 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein RHD_DNA_bind PF00554.20 NM_009044.2_3 - 6.5e-75 250.6 0.0 9.6e-75 250.0 0.0 1.3 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 NM_009044.2_3 - 1.5e-36 124.4 0.0 2.5e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain SSF PF00474.15 NM_001177624.1_1 - 9.7e-45 153.0 24.0 1.3e-44 152.6 24.0 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family Glyco_transf_6 PF03414.11 NM_010283.4_1 - 8.9e-162 537.2 3.6 1.1e-161 536.8 3.6 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 6 DNA_pol3_delta2 PF13177.4 NM_027009.2_3 - 6e-12 45.5 0.3 6e-12 45.5 0.3 1.6 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA PF00004.27 NM_027009.2_3 - 2.8e-07 30.9 0.0 5.8e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.13 NM_027009.2_3 - 1.2e-06 27.6 0.1 1.7e-06 27.1 0.1 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.4 NM_027009.2_3 - 0.0089 16.3 0.2 0.037 14.3 0.1 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 NM_027009.2_3 - 0.017 15.3 0.6 0.073 13.2 0.1 2.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.25 NM_027009.2_3 - 0.026 14.9 0.0 0.046 14.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter ATPgrasp_ST PF14397.4 NM_027009.2_3 - 0.052 12.7 0.1 0.15 11.2 0.2 1.6 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp DNA_pol3_delta PF06144.11 NM_027009.2_3 - 0.068 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Sigma54_activ_2 PF14532.4 NM_027009.2_3 - 0.072 13.1 0.2 0.24 11.4 0.1 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF2247 PF10004.7 NM_027009.2_3 - 0.077 12.6 0.2 0.13 11.9 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) CHB_HEX PF03173.11 NM_027009.2_3 - 0.099 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative carbohydrate binding domain HTH_Tnp_Mu_2 PF09039.9 NM_027009.2_3 - 0.099 12.6 0.7 16 5.5 0.0 3.0 3 0 0 3 3 3 0 Mu DNA binding, I gamma subdomain AAA_5 PF07728.12 NM_027009.2_3 - 0.13 12.2 0.1 0.28 11.1 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Furin-like_2 PF15913.3 NM_172815.3_1 - 4e-47 158.7 25.5 8.4e-47 157.6 25.5 1.6 1 0 0 1 1 1 1 Furin-like repeat, cysteine-rich ADIP PF11559.6 NM_138744.3_3 - 7.9e-43 146.0 18.6 7.9e-43 146.0 18.6 3.3 3 1 0 3 3 3 1 Afadin- and alpha -actinin-Binding DUF3605 PF12239.6 NM_138744.3_3 - 0.14 12.3 2.9 0.39 10.9 2.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3605) HSP70 PF00012.18 NM_011020.3_3 - 3.3e-190 633.1 4.3 2.1e-189 630.5 0.9 2.4 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.11 NM_011020.3_3 - 1.3e-07 30.6 0.0 4.4e-07 28.9 0.0 1.7 2 0 0 2 2 2 1 MreB/Mbl protein TCRP1 PF14944.4 NM_178764.3_2 - 1.9e-107 358.6 52.6 2.6e-107 358.2 52.6 1.2 1 0 0 1 1 1 1 Tongue Cancer Chemotherapy Resistant Protein 1 TLE_N PF03920.13 NM_001252401.1_1 - 5.2e-61 204.3 7.5 8.2e-61 203.7 7.5 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.30 NM_001252401.1_1 - 3.2e-18 65.6 22.8 0.0089 16.7 0.3 7.9 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001252401.1_1 - 8.4e-07 29.1 0.0 0.53 10.5 0.0 3.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_001252401.1_1 - 0.0046 16.2 0.0 1.4 8.0 0.1 2.4 2 1 0 2 2 2 2 WD40-like domain HALZ PF02183.16 NM_001252401.1_1 - 0.04 14.0 0.3 0.084 13.0 0.3 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper EGF_CA PF07645.13 NM_024237.4_1 - 4.1e-19 68.4 44.8 1.7e-11 43.9 7.9 4.8 5 0 0 5 5 5 3 Calcium-binding EGF domain cEGF PF12662.5 NM_024237.4_1 - 6.4e-16 57.8 29.3 2.8e-10 39.8 2.5 5.5 5 0 0 5 5 5 4 Complement Clr-like EGF-like EGF PF00008.25 NM_024237.4_1 - 2.3e-11 43.6 22.7 1.1e-08 35.1 11.5 5.2 5 0 0 5 5 5 2 EGF-like domain Sushi PF00084.18 NM_024237.4_1 - 4.8e-10 39.8 0.6 4.8e-10 39.8 0.6 2.8 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) hEGF PF12661.5 NM_024237.4_1 - 2.1e-09 37.5 39.8 9.5e-06 26.0 9.1 5.6 5 0 0 5 5 5 3 Human growth factor-like EGF FXa_inhibition PF14670.4 NM_024237.4_1 - 1.1e-08 35.0 4.0 1.1e-08 35.0 4.0 4.8 4 0 0 4 4 4 2 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 NM_024237.4_1 - 0.069 13.2 34.3 0.026 14.6 1.7 5.1 5 0 0 5 5 5 0 EGF domain Prominin PF05478.9 NM_001163585.1_2 - 5.2e-293 973.8 10.1 6.8e-293 973.4 10.1 1.1 1 0 0 1 1 1 1 Prominin Tweety PF04906.11 NM_001163585.1_2 - 9.9e-08 30.9 11.4 9.3e-06 24.4 2.9 3.2 3 0 0 3 3 3 2 Tweety DUF2207 PF09972.7 NM_001163585.1_2 - 0.0017 17.1 0.0 0.0017 17.1 0.0 3.5 4 1 1 5 5 5 1 Predicted membrane protein (DUF2207) Baculo_PEP_C PF04513.10 NM_001163585.1_2 - 0.0051 16.7 28.8 0.065 13.1 0.9 4.7 3 1 1 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus FliD_N PF02465.16 NM_001163585.1_2 - 0.023 15.3 1.2 0.023 15.3 1.2 3.1 4 1 0 4 4 3 0 Flagellar hook-associated protein 2 N-terminus DUF1664 PF07889.10 NM_001163585.1_2 - 0.041 13.7 0.4 0.041 13.7 0.4 4.5 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) Collagen_mid PF15984.3 NM_001163585.1_2 - 0.059 13.0 0.5 0.15 11.7 0.2 1.7 1 1 0 1 1 1 0 Bacterial collagen, middle region Sipho_Gp157 PF05565.9 NM_001163585.1_2 - 0.062 13.2 0.4 0.39 10.6 0.1 2.3 1 1 1 2 2 2 0 Siphovirus Gp157 Fez1 PF06818.13 NM_001163585.1_2 - 0.11 12.7 1.3 0.34 11.2 1.2 1.8 1 1 0 1 1 1 0 Fez1 MCPsignal PF00015.19 NM_001163585.1_2 - 0.11 12.1 10.2 0.22 11.1 2.5 3.0 3 1 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Phasin PF05597.9 NM_001163585.1_2 - 0.13 12.2 0.1 31 4.5 0.0 2.9 2 1 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) CENP-Q PF13094.4 NM_001163585.1_2 - 0.2 11.7 5.8 0.21 11.6 0.5 2.8 3 1 0 3 3 2 0 CENP-Q, a CENPA-CAD centromere complex subunit MscS_porin PF12795.5 NM_001163585.1_2 - 0.36 10.2 10.3 0.93 8.9 4.3 2.9 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain ApoLp-III PF07464.9 NM_001163585.1_2 - 0.36 10.8 18.0 0.16 11.9 1.0 3.7 2 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Exonuc_VII_L PF02601.13 NM_001163585.1_2 - 0.37 10.2 6.1 0.036 13.5 1.4 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit Uso1_p115_C PF04871.11 NM_001163585.1_2 - 0.4 10.9 2.7 16 5.7 0.6 2.6 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4404 PF14357.4 NM_001163585.1_2 - 0.9 10.1 4.7 1.9 9.1 0.4 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) LXG PF04740.10 NM_001163585.1_2 - 1.4 8.5 6.3 2.8 7.5 1.1 2.8 2 0 0 2 2 2 0 LXG domain of WXG superfamily ZapB PF06005.10 NM_001163585.1_2 - 1.4 9.2 5.8 2.6 8.4 1.0 2.7 2 0 0 2 2 2 0 Cell division protein ZapB CLZ PF16526.3 NM_001163585.1_2 - 1.7 8.9 5.8 15 5.9 0.4 3.3 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4131 PF13567.4 NM_001163585.1_2 - 1.9 7.9 10.0 7.2 6.0 0.5 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Fzo_mitofusin PF04799.11 NM_001163585.1_2 - 2.1 7.7 11.5 1 8.7 0.4 4.0 4 0 0 4 4 4 0 fzo-like conserved region DUF848 PF05852.9 NM_001163585.1_2 - 2.7 8.0 6.0 6.3 6.8 0.5 3.0 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) YojJ PF10372.7 NM_001163585.1_2 - 4.1 7.4 7.3 20 5.2 0.0 4.1 4 0 0 4 4 3 0 Bacterial membrane-spanning protein N-terminus DUF4795 PF16043.3 NM_001163585.1_2 - 5.5 6.4 7.9 2.4 7.6 0.1 3.3 4 0 0 4 4 3 0 Domain of unknown function (DUF4795) Reo_sigmaC PF04582.10 NM_001163585.1_2 - 5.9 6.1 18.1 4.2 6.5 6.8 2.7 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Laminin_II PF06009.10 NM_001163585.1_2 - 6.7 6.6 18.8 0.19 11.6 2.1 3.6 4 0 0 4 4 3 0 Laminin Domain II FimP PF09766.7 NM_001163585.1_2 - 8 5.5 13.0 2.2 7.4 2.2 3.1 3 0 0 3 3 3 0 Fms-interacting protein HIP1_clath_bdg PF16515.3 NM_001163585.1_2 - 8.1 7.0 6.6 0.97 9.9 1.0 2.4 3 0 0 3 3 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF16 PF01519.14 NM_001163585.1_2 - 8.3 6.8 11.2 6.9 7.1 0.6 3.7 4 0 0 4 4 3 0 Protein of unknown function DUF16 Antimicrobial24 PF16049.3 NM_001163585.1_2 - 9 6.3 6.2 1.7 8.5 0.8 2.4 2 0 0 2 2 2 0 Frog antimicrobial peptide Rif1_N PF12231.6 NM_175238.5_2 - 8.8e-74 248.6 4.2 8.8e-74 248.6 4.2 1.8 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal NICE-1 PF15845.3 NM_175238.5_2 - 0.25 12.0 7.9 0.022 15.4 1.9 2.4 2 0 0 2 2 2 0 Cysteine-rich C-terminal 1 family TBD PF12845.5 NM_198100.2_1 - 1.6e-17 63.0 0.1 7e-17 60.9 0.1 2.2 1 0 0 1 1 1 1 TBD domain CT_C_D PF02682.14 NM_198100.2_1 - 0.29 10.7 2.4 0.7 9.5 0.3 2.2 2 0 0 2 2 2 0 Carboxyltransferase domain, subdomain C and D Seryl_tRNA_N PF02403.20 NM_198100.2_1 - 0.59 10.3 11.7 0.2 11.8 1.7 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.12 NM_198100.2_1 - 2.2 7.9 25.8 0.012 15.3 3.5 2.7 2 1 0 2 2 2 0 IncA protein APG6 PF04111.10 NM_198100.2_1 - 2.3 7.4 15.8 2.7 7.2 3.1 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 Cor1 PF04803.10 NM_198100.2_1 - 3.1 7.9 14.2 0.21 11.7 8.3 1.8 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Mod_r PF07200.11 NM_198100.2_1 - 5.2 7.0 16.3 0.067 13.2 4.8 2.3 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Pkinase PF00069.23 NM_001291152.1_1 - 1.1e-67 228.0 0.0 1.5e-67 227.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001291152.1_1 - 6.7e-33 113.9 0.0 9.3e-33 113.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001291152.1_1 - 4.4e-05 22.8 0.0 8.2e-05 21.9 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.22 NM_001291152.1_1 - 0.0002 21.8 0.1 0.00043 20.8 0.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.12 NM_001291152.1_1 - 0.0054 16.0 0.0 0.0084 15.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DEAD PF00270.27 NM_001110826.1_1 - 3e-42 144.2 0.7 1.6e-41 141.9 0.4 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001110826.1_1 - 7e-27 93.9 0.8 2.5e-26 92.1 0.5 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.4 NM_001110826.1_1 - 0.0027 16.9 0.2 0.0047 16.2 0.2 1.2 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit WD40 PF00400.30 NM_028866.3_3 - 1.1e-30 105.0 14.5 2.8e-06 27.8 0.0 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_028866.3_3 - 3.2e-10 40.0 1.6 0.64 10.2 0.1 5.3 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Collagen PF01391.16 NM_028866.3_3 - 4.9e-05 22.9 40.4 4.9e-05 22.9 40.4 8.3 4 1 2 6 6 6 2 Collagen triple helix repeat (20 copies) eIF2A PF08662.9 NM_028866.3_3 - 5.1e-05 23.1 3.2 0.085 12.6 0.7 2.8 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 NM_028866.3_3 - 0.0019 17.1 0.1 0.019 13.8 0.1 2.3 1 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein 7tm_1 PF00001.19 NM_008285.4_3 - 3.7e-67 226.3 0.4 5.1e-67 225.8 0.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_008285.4_3 - 9e-07 28.4 12.2 0.0001 21.7 4.3 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_008285.4_3 - 3.4e-05 23.6 12.6 5e-05 23.0 6.3 2.7 2 1 0 2 2 2 1 Olfactory receptor LIM PF00412.20 NM_008505.4_2 - 9.9e-27 92.8 20.7 9.5e-15 54.4 9.0 2.3 2 0 0 2 2 2 2 LIM domain CAP_N PF01213.17 NM_008505.4_2 - 2.7 7.3 6.1 3.9 6.7 6.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal LON_substr_bdg PF02190.14 NM_001029878.1_1 - 5.2e-23 81.9 0.0 7.7e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.4 NM_001029878.1_1 - 1.5e-08 34.2 15.7 1.5e-08 34.2 15.7 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001029878.1_1 - 9.5e-08 31.6 9.1 4.1e-07 29.6 9.1 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001029878.1_1 - 1.9e-05 24.3 13.8 1.9e-05 24.3 13.8 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001029878.1_1 - 2.2e-05 24.2 9.3 2.2e-05 24.2 9.3 2.8 2 1 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_001029878.1_1 - 4e-05 23.6 14.3 4e-05 23.6 14.3 2.8 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_4 PF15227.4 NM_001029878.1_1 - 0.00022 21.2 13.5 0.00022 21.2 13.5 3.2 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 NM_001029878.1_1 - 0.00041 20.1 12.2 0.00041 20.1 12.2 2.8 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.4 NM_001029878.1_1 - 0.00054 19.6 11.0 0.00054 19.6 11.0 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 NM_001029878.1_1 - 0.0057 16.6 7.5 0.0057 16.6 7.5 2.0 2 0 0 2 2 1 1 zinc RING finger of MSL2 U-box PF04564.13 NM_001029878.1_1 - 0.021 14.9 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 U-box domain zf-rbx1 PF12678.5 NM_001029878.1_1 - 0.17 12.0 15.5 0.025 14.7 8.7 2.8 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-C4H2 PF10146.7 NM_001029878.1_1 - 1.5 9.0 6.2 2.8 8.0 6.2 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein UBD PF16455.3 NM_145500.3_3 - 1.4e-36 124.7 0.0 2.1e-36 124.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.21 NM_145500.3_3 - 1.3e-14 53.6 0.1 1.9e-14 53.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 NM_145500.3_3 - 6.4e-06 25.8 0.0 8.8e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DMRT-like PF15791.3 NM_001038616.2_2 - 3.5e-41 140.2 7.1 3.5e-41 140.2 7.1 1.4 2 0 0 2 2 2 1 Doublesex-and mab-3-related transcription factor C1 and C2 Lamp PF01299.15 NM_010684.3_1 - 1.2e-118 396.1 11.0 2.7e-114 381.8 3.5 2.0 1 1 1 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.10 NM_010684.3_1 - 4.3e-07 29.7 2.4 5.4e-05 22.9 0.0 2.4 2 0 0 2 2 2 2 Vacuolar ATP synthase subunit S1 (ATP6S1) DUF4597 PF15366.4 NM_001308449.1_3 - 3.4e-39 132.3 0.6 3.4e-39 132.3 0.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4597) UPF0172 PF03665.11 NM_001308449.1_3 - 3.5e-23 82.5 0.1 5e-23 82.0 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Guanylate_kin PF00625.19 NM_011807.3_3 - 5.6e-65 218.3 0.1 8.1e-65 217.8 0.1 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 NM_011807.3_3 - 2.6e-64 213.4 8.4 3.9e-21 75.0 0.1 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) MAGUK_N_PEST PF10608.7 NM_011807.3_3 - 3.6e-32 111.2 5.0 9.7e-19 67.9 0.2 2.6 1 1 1 2 2 2 2 Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_assoc PF10600.7 NM_011807.3_3 - 6.4e-24 84.4 7.4 6.4e-24 84.4 7.4 2.4 2 0 0 2 2 2 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 NM_011807.3_3 - 1.5e-15 57.1 2.4 0.00038 20.6 0.0 3.4 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.15 NM_011807.3_3 - 2.3e-08 33.4 0.0 5.1e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_011807.3_3 - 4.2e-08 32.5 0.0 8.2e-08 31.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_011807.3_3 - 0.0064 16.2 0.0 0.017 14.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain TAS2R PF05296.11 NM_001167167.1_1 - 1.4e-15 57.1 19.2 1.8e-15 56.7 19.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 NM_001167167.1_1 - 4.4e-14 52.6 13.8 6e-14 52.2 13.8 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 NM_001167167.1_1 - 6.5e-07 28.7 16.7 8.4e-07 28.3 16.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PRP8_domainIV PF12134.6 NM_001167167.1_1 - 0.012 15.2 0.8 0.11 12.0 0.1 2.5 2 1 1 3 3 3 0 PRP8 domain IV core DUF1700 PF08006.9 NM_001167167.1_1 - 0.11 11.9 8.5 0.082 12.3 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Anoctamin PF04547.10 NM_001167167.1_1 - 0.78 8.3 10.0 0.7 8.5 9.2 1.5 1 1 0 1 1 1 0 Calcium-activated chloride channel RITA PF17066.3 NM_029096.3_1 - 5.9e-102 340.7 24.0 5.9e-102 340.7 24.0 1.7 2 0 0 2 2 2 1 RBPJ-interacting and tubulin associated protein GYF PF02213.14 NM_001285906.1_1 - 5.7e-18 64.3 1.3 1.3e-17 63.1 1.3 1.6 1 0 0 1 1 1 1 GYF domain BRICHOS PF04089.12 NM_001310655.1_2 - 3.2e-19 68.6 0.0 5.5e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain Defensin_propep PF00879.16 NM_007850.2_2 - 5.9e-23 80.8 0.3 7.9e-23 80.4 0.3 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 NM_007850.2_2 - 5.1e-10 39.6 16.7 7e-10 39.1 16.7 1.2 1 0 0 1 1 1 1 Mammalian defensin MF_alpha_N PF05436.9 NM_007850.2_2 - 0.015 15.1 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus Rdx PF10262.7 NM_009156.2_2 - 2.3e-06 27.6 0.0 3.9e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Rdx family PMP22_Claudin PF00822.18 NM_021719.4_2 - 7.9e-33 113.5 9.0 1.1e-32 113.0 9.0 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_021719.4_2 - 3e-06 27.0 6.8 3.5e-06 26.8 5.9 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction SUR7 PF06687.10 NM_021719.4_2 - 0.023 14.2 2.1 0.04 13.4 2.1 1.3 1 0 0 1 1 1 0 SUR7/PalI family TMEM238 PF15125.4 NM_021719.4_2 - 9.1 6.4 8.7 0.78 9.8 2.3 2.3 2 0 0 2 2 2 0 TMEM238 protein family SCAMP PF04144.11 NM_001310016.1_1 - 3.4e-67 226.0 16.4 5e-67 225.4 16.4 1.2 1 0 0 1 1 1 1 SCAMP family Pkinase PF00069.23 NM_001310016.1_1 - 4.2e-42 144.2 0.1 6e-42 143.7 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001310016.1_1 - 4.1e-20 72.0 0.0 5.9e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AAA_23 PF13476.4 NM_001310016.1_1 - 0.24 11.8 0.6 31 4.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain Phage_holin_3_6 PF07332.9 NM_001310016.1_1 - 6.6 6.7 10.0 0.71 9.8 5.2 1.8 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Tantalus PF15386.4 NM_194340.2_3 - 4.1e-24 84.3 2.1 8.4e-24 83.3 2.1 1.5 1 0 0 1 1 1 1 Drosophila Tantalus-like IBN_N PF03810.17 NM_029665.3_1 - 3e-19 68.6 0.7 2.9e-18 65.4 0.0 3.0 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.10 NM_029665.3_1 - 0.00093 19.2 4.0 0.042 13.8 0.0 4.2 4 0 0 4 4 4 1 Exportin 1-like protein HEAT_2 PF13646.4 NM_029665.3_1 - 0.028 14.6 0.0 0.18 12.0 0.0 2.4 2 1 1 3 3 3 0 HEAT repeats V-set PF07686.15 NM_007962.4_1 - 1.5e-20 73.2 0.0 2.4e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 NM_007962.4_1 - 4.5e-08 33.0 0.0 9.4e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_007962.4_1 - 0.0033 17.9 0.0 0.0069 16.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_007962.4_1 - 0.023 14.9 0.2 0.31 11.3 0.0 2.6 2 1 0 2 2 2 0 Immunoglobulin domain I-set PF07679.14 NM_007962.4_1 - 0.057 13.4 0.0 0.17 11.8 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin I-set domain EphA2_TM PF14575.4 NM_007962.4_1 - 0.12 13.0 0.0 0.23 12.2 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.4 NM_007962.4_1 - 0.15 11.8 0.1 0.23 11.2 0.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family Pyridoxal_deC PF00282.17 NM_008230.6_2 - 5.7e-171 568.2 0.0 7.2e-171 567.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.19 NM_008230.6_2 - 0.00075 18.7 0.0 0.0011 18.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.19 NM_008230.6_2 - 0.0019 17.3 0.0 0.0031 16.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4638 PF15472.4 NM_177901.3_2 - 1.7e-121 405.1 16.2 1.9e-121 404.9 16.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4638) V_ATPase_I PF01496.17 NM_177901.3_2 - 0.55 7.9 5.1 0.64 7.7 5.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family 7tm_1 PF00001.19 NM_008041.2_1 - 1e-33 116.6 28.7 1e-33 116.6 28.7 2.3 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Gelsolin PF00626.20 NM_001271415.1_2 - 4.2e-57 189.8 0.0 2.7e-19 68.7 0.0 3.2 3 0 0 3 3 3 3 Gelsolin repeat eIF3_N PF09440.8 NM_008388.2_3 - 8.7e-47 158.8 3.9 3e-46 157.0 3.9 2.0 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.25 NM_008388.2_3 - 6.4e-20 71.5 0.0 2.7e-19 69.5 0.0 2.1 1 0 0 1 1 1 1 PCI domain CSN8_PSD8_EIF3K PF10075.7 NM_008388.2_3 - 0.025 14.4 0.6 0.11 12.4 0.0 2.3 3 0 0 3 3 3 0 CSN8/PSMD8/EIF3K family SPESP1 PF15754.3 NM_008388.2_3 - 0.044 12.8 0.3 6.9 5.6 0.1 2.2 2 0 0 2 2 2 0 Sperm equatorial segment protein 1 HD_assoc PF13286.4 NM_008388.2_3 - 0.084 13.3 1.3 3.1 8.3 0.2 2.5 2 0 0 2 2 2 0 Phosphohydrolase-associated domain CTNNB1_binding PF08347.9 NM_001276403.1_1 - 1.1e-50 172.5 7.7 1.1e-50 172.5 7.7 1.8 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 NM_001276403.1_1 - 1.8e-21 76.2 0.7 1.8e-21 76.2 0.7 2.5 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_001276403.1_1 - 2.4e-08 34.3 2.1 5.9e-08 33.1 0.8 2.1 2 0 0 2 2 2 1 HMG-box domain NDK PF00334.17 NM_008705.5_1 - 8.6e-56 187.5 0.0 1.1e-55 187.2 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase OTU PF02338.17 NM_173443.3_2 - 2.5e-11 44.1 0.0 4.6e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease p450 PF00067.20 NM_001004141.2_3 - 3e-131 438.2 0.1 3.5e-131 438.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Laminin_G_2 PF02210.22 NM_130457.2_3 - 1.6e-87 290.4 1.0 1.4e-23 83.7 0.0 4.4 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.21 NM_130457.2_3 - 1.6e-58 196.5 0.0 1.3e-16 60.9 0.0 4.3 4 0 0 4 4 4 4 Laminin G domain F5_F8_type_C PF00754.23 NM_130457.2_3 - 1.1e-28 99.8 0.4 4.4e-28 97.8 0.1 2.2 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_3 PF13385.4 NM_130457.2_3 - 1.6e-09 37.9 0.0 0.0013 18.7 0.0 3.6 4 0 0 4 4 4 2 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 NM_130457.2_3 - 2.3e-05 24.5 35.5 0.00054 20.1 9.4 3.6 3 0 0 3 3 3 2 EGF-like domain COLFI PF01410.16 NM_130457.2_3 - 0.003 16.8 0.4 0.046 12.9 0.4 2.3 1 1 0 1 1 1 1 Fibrillar collagen C-terminal domain LIM PF00412.20 NM_001083127.1_3 - 2.3e-29 101.2 19.2 1e-14 54.3 3.0 3.4 3 0 0 3 3 3 2 LIM domain Homeobox PF00046.27 NM_001083127.1_3 - 3.7e-19 68.1 1.6 6.5e-19 67.4 1.6 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_001083127.1_3 - 0.00057 19.6 0.2 0.0014 18.4 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain zf-dskA_traR PF01258.15 NM_001083127.1_3 - 0.017 14.9 0.7 1.6 8.6 0.0 2.8 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger Syja_N PF02383.16 NM_001113352.2_1 - 2.3e-65 220.8 0.0 3.2e-65 220.3 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain DUF1866 PF08952.9 NM_001113352.2_1 - 1.1e-59 200.3 0.1 1.8e-59 199.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.21 NM_001113352.2_1 - 2.5e-07 30.8 0.0 6e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.30 NM_177267.4_3 - 1.4e-17 63.6 9.6 0.0017 19.0 0.1 6.3 5 0 0 5 5 5 5 WD domain, G-beta repeat Frtz PF11768.6 NM_177267.4_3 - 0.091 10.9 0.0 0.14 10.3 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Herpes_pp85 PF04637.10 NM_177267.4_3 - 3.9 5.6 6.2 5.8 5.1 6.2 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) 2OG-FeII_Oxy_2 PF13532.4 NM_025538.3_2 - 5.3e-12 46.2 0.0 9.3e-11 42.2 0.0 2.1 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.4 NM_026303.1_1 - 3.2e-22 79.6 0.0 9.5e-22 78.1 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Methyltransf_11 PF08241.10 NM_026303.1_1 - 2.8e-15 56.6 0.1 5.5e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF1891 PF09004.8 NM_026303.1_1 - 6.1e-15 54.4 1.4 1.4e-14 53.3 1.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) Methyltransf_25 PF13649.4 NM_026303.1_1 - 1.1e-13 51.5 0.1 2.3e-13 50.5 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain RRM_1 PF00076.20 NM_026303.1_1 - 5.1e-08 32.5 0.0 1.2e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_23 PF13489.4 NM_026303.1_1 - 2.1e-06 27.6 0.0 5.7e-06 26.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_026303.1_1 - 5.5e-06 26.1 0.0 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_026303.1_1 - 9.2e-06 26.2 0.0 2.1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.13 NM_026303.1_1 - 2.4e-05 24.2 0.0 4.2e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Ubie_methyltran PF01209.16 NM_026303.1_1 - 0.0058 15.9 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family RRM_occluded PF16842.3 NM_026303.1_1 - 0.069 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif Vasculin PF15337.4 NM_026303.1_1 - 0.086 13.6 0.6 0.25 12.0 0.1 2.0 2 0 0 2 2 1 0 Vascular protein family Vasculin-like 1 MetW PF07021.10 NM_026303.1_1 - 0.09 12.2 0.1 0.16 11.4 0.1 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW 2OG-FeII_Oxy PF03171.18 NM_026303.1_1 - 0.1 12.9 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily UQ_con PF00179.24 NM_001284314.1_1 - 5.9e-18 64.7 0.1 9.2e-18 64.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Integrin_alpha2 PF08441.10 NM_001253873.1_3 - 2.6e-43 148.5 0.0 3.8e-43 147.9 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 NM_001253873.1_3 - 1.4e-30 106.8 1.0 1.9e-30 106.3 1.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 NM_001253873.1_3 - 1.2e-14 54.0 7.9 2.3e-07 30.7 0.1 4.0 4 0 0 4 4 4 3 FG-GAP repeat VWA_2 PF13519.4 NM_001253873.1_3 - 3.9e-08 33.8 0.0 7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 NM_001253873.1_3 - 5.3e-05 23.6 0.0 0.019 15.4 0.0 2.8 2 1 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 NM_001253873.1_3 - 0.00011 22.3 9.2 0.038 14.1 0.3 4.5 4 0 0 4 4 4 2 FG-GAP repeat Integrin_alpha PF00357.18 NM_001253873.1_3 - 0.00044 19.9 0.4 0.00044 19.9 0.4 1.9 2 0 0 2 2 2 1 Integrin alpha cytoplasmic region INSIG PF07281.10 NM_178082.3_3 - 4e-46 157.2 6.3 1.3e-45 155.5 6.3 1.8 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) DUF478 PF04334.10 NM_001177402.1_3 - 0.25 11.3 1.9 3.4 7.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF478) Ribonuc_P_40 PF08584.9 NM_145938.4_1 - 6.1e-93 311.1 0.0 7.7e-93 310.7 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit NHL PF01436.19 NM_018880.3_1 - 5.2e-50 164.9 22.5 1.1e-09 37.7 0.2 6.7 6 0 0 6 6 6 6 NHL repeat Filamin PF00630.17 NM_018880.3_1 - 8.9e-18 64.9 0.0 2.7e-17 63.3 0.0 1.9 2 0 0 2 2 1 1 Filamin/ABP280 repeat DUF5128 PF17170.2 NM_018880.3_1 - 9.5e-16 57.7 2.8 5.1e-07 29.0 0.1 3.6 1 1 3 4 4 4 4 6-bladed beta-propeller SGL PF08450.10 NM_018880.3_1 - 5.2e-14 52.3 4.3 5.6e-05 22.7 0.0 5.0 1 1 3 4 4 4 3 SMP-30/Gluconolaconase/LRE-like region zf-B_box PF00643.22 NM_018880.3_1 - 1.3e-10 41.1 2.5 1.3e-10 41.1 2.5 2.8 2 1 0 2 2 1 1 B-box zinc finger zf-RING_UBOX PF13445.4 NM_018880.3_1 - 1.1e-07 31.6 11.8 1.1e-07 31.6 9.8 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_018880.3_1 - 2.7e-06 27.0 12.6 2.7e-06 27.0 12.6 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_018880.3_1 - 3.3e-06 26.7 10.6 3.3e-06 26.7 10.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_018880.3_1 - 4.8e-06 26.3 10.9 4.8e-06 26.3 10.9 2.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_018880.3_1 - 7.2e-06 26.0 12.7 7.2e-06 26.0 12.7 2.3 2 0 0 2 2 1 1 Ring finger domain DUF4934 PF16288.3 NM_018880.3_1 - 1.8e-05 24.5 1.6 0.14 12.0 0.3 3.3 2 1 1 3 3 3 3 Domain of unknown function (DUF4934) zf-C3HC4_2 PF13923.4 NM_018880.3_1 - 2.1e-05 24.1 12.7 2.1e-05 24.1 12.7 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) SBBP PF06739.9 NM_018880.3_1 - 6.2e-05 22.8 1.8 0.69 9.8 0.4 3.4 3 0 0 3 3 3 1 Beta-propeller repeat Prok-RING_4 PF14447.4 NM_018880.3_1 - 0.0026 17.5 11.3 0.0026 17.5 11.3 2.2 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 Invasin_D3 PF09134.8 NM_018880.3_1 - 0.08 12.6 0.0 0.22 11.1 0.0 1.7 1 0 0 1 1 1 0 Invasin, domain 3 zf-RING_11 PF17123.3 NM_018880.3_1 - 0.11 12.1 4.5 0.41 10.3 4.5 2.1 1 0 0 1 1 1 0 RING-like zinc finger Apolipoprotein PF01442.16 NM_018880.3_1 - 0.12 12.1 7.3 0.22 11.3 7.3 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain CENP-F_leu_zip PF10473.7 NM_018880.3_1 - 0.13 12.1 2.4 0.23 11.3 2.4 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YojJ PF10372.7 NM_018880.3_1 - 0.25 11.3 1.6 1.3 9.1 0.7 2.2 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus VCBS PF13517.4 NM_018880.3_1 - 0.36 11.3 6.9 10 6.6 0.2 4.3 3 2 2 5 5 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Baculo_PEP_C PF04513.10 NM_018880.3_1 - 0.41 10.5 2.2 1 9.3 2.2 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-ANAPC11 PF12861.5 NM_018880.3_1 - 0.62 10.0 9.3 0.023 14.6 3.1 1.8 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 NM_018880.3_1 - 6.8 6.8 25.2 0.025 14.6 14.9 2.4 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING Neur_chan_LBD PF02931.21 NM_183427.4_2 - 4.7e-53 179.7 0.0 6.2e-53 179.3 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_183427.4_2 - 8.4e-38 130.6 5.1 7.3e-33 114.5 1.7 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region VGCC_alpha2 PF08473.9 NM_009785.1_2 - 3.8e-37 128.0 2.4 6.7e-37 127.2 2.4 1.3 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.9 NM_009785.1_2 - 5.1e-37 127.0 0.1 1.1e-36 125.9 0.1 1.6 1 0 0 1 1 1 1 VWA N-terminal VWA_3 PF13768.4 NM_009785.1_2 - 3.5e-14 52.8 0.0 6.5e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.16 NM_009785.1_2 - 9.4e-14 51.7 2.3 2.9e-10 40.3 0.1 3.6 3 1 0 3 3 3 2 Cache domain VWA PF00092.26 NM_009785.1_2 - 4.2e-12 46.5 0.1 8.5e-12 45.5 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 NM_009785.1_2 - 2.2e-09 37.8 0.1 4.8e-09 36.7 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_2 PF08269.9 NM_009785.1_2 - 0.00046 19.3 0.1 0.0047 16.0 0.1 2.3 2 0 0 2 2 2 1 Cache domain RNase_Zc3h12a_2 PF14626.4 NM_009785.1_2 - 0.015 15.2 0.1 28 4.7 0.0 4.0 3 1 1 4 4 4 0 Zc3h12a-like Ribonuclease NYN domain Cache_3-Cache_2 PF17201.2 NM_009785.1_2 - 0.019 14.2 0.0 0.052 12.7 0.0 1.6 2 0 0 2 2 2 0 Cache 3/Cache 2 fusion domain VWA_CoxE PF05762.12 NM_009785.1_2 - 0.029 13.6 0.0 0.057 12.7 0.0 1.4 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Ceramidase_alk PF04734.11 NM_018830.1_3 - 3e-218 725.4 0.0 3.7e-218 725.1 0.0 1.1 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.3 NM_018830.1_3 - 4e-46 156.8 0.0 5.6e-46 156.3 0.0 1.2 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal EMP70 PF02990.14 NM_133352.2_1 - 1.5e-158 528.5 20.1 2e-158 528.1 20.1 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 GAS2 PF02187.15 NM_001190408.1_2 - 3.8e-32 110.1 0.1 6.6e-32 109.3 0.1 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.29 NM_001190408.1_2 - 9.1e-15 54.7 0.0 1.3e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Spectrin PF00435.19 NM_001199136.1_1 - 1.1e-202 658.9 438.5 5.2e-17 62.1 4.0 43.1 41 3 1 43 43 42 33 Spectrin repeat Plectin PF00681.18 NM_001199136.1_1 - 3.7e-109 356.2 26.8 5.4e-15 54.9 0.0 17.0 12 5 5 17 17 17 14 Plectin repeat CH PF00307.29 NM_001199136.1_1 - 3.3e-46 155.8 2.6 1.2e-21 76.8 0.5 4.8 4 0 0 4 4 4 2 Calponin homology (CH) domain GAS2 PF02187.15 NM_001199136.1_1 - 8.2e-31 105.8 0.3 2.6e-30 104.2 0.3 2.0 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_1 PF00036.30 NM_001199136.1_1 - 1.8e-11 42.6 2.2 0.00014 21.0 0.7 3.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 NM_001199136.1_1 - 6.5e-11 42.4 0.9 9.7e-10 38.7 0.9 3.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_001199136.1_1 - 1.9e-10 39.7 1.6 0.00071 19.2 0.4 3.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 NM_001199136.1_1 - 5.8e-08 32.3 0.2 2.7e-07 30.1 0.2 2.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 NM_001199136.1_1 - 1.3e-07 30.6 4.1 4.1e-05 22.8 1.4 3.0 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.6 NM_001199136.1_1 - 7.7e-06 25.5 0.8 0.0051 16.5 0.0 3.9 3 0 0 3 3 3 1 CAMSAP CH domain Laminin_II PF06009.10 NM_001199136.1_1 - 0.0015 18.4 3.6 0.0015 18.4 3.6 23.0 22 4 3 25 25 23 3 Laminin Domain II CcdA PF07362.10 NM_001199136.1_1 - 6.2 7.2 7.8 21 5.5 2.3 4.9 3 0 0 3 3 2 0 Post-segregation antitoxin CcdA DUF19 PF01579.16 NM_001199136.1_1 - 9 5.9 12.5 0.31 10.7 0.9 4.7 3 0 0 3 3 3 0 Domain of unknown function (DUF19) BAF PF02961.12 NM_011793.3_2 - 7.1e-43 144.8 0.0 9.9e-43 144.4 0.0 1.2 1 0 0 1 1 1 1 Barrier to autointegration factor IMS_HHH PF11798.6 NM_011793.3_2 - 0.018 15.2 0.6 0.23 11.8 0.0 2.8 2 1 1 3 3 3 0 IMS family HHH motif CPSase_L_D2 PF02786.15 NM_001080809.2_1 - 1.3e-116 387.3 0.7 6.3e-84 280.6 0.1 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.20 NM_001080809.2_1 - 6e-44 148.8 0.0 1.9e-43 147.2 0.0 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.26 NM_001080809.2_1 - 5.3e-39 133.8 0.0 1e-38 132.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.17 NM_001080809.2_1 - 9.1e-39 132.4 0.2 1.9e-38 131.4 0.2 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.20 NM_001080809.2_1 - 9.6e-20 70.7 0.5 1e-10 41.3 0.1 2.3 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.20 NM_001080809.2_1 - 2.3e-19 69.2 0.0 1.6e-18 66.5 0.0 2.4 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.11 NM_001080809.2_1 - 9.7e-14 51.2 0.6 4.4e-06 26.2 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.4 NM_001080809.2_1 - 2.1e-11 43.0 0.0 3.4e-06 25.9 0.0 3.4 3 1 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.12 NM_001080809.2_1 - 2.5e-05 24.2 0.5 0.097 12.6 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain DJ-1_PfpI PF01965.22 NM_001080809.2_1 - 0.022 14.4 0.1 0.23 11.1 0.0 2.6 3 0 0 3 3 3 0 DJ-1/PfpI family ATP-grasp_5 PF13549.4 NM_001080809.2_1 - 0.097 12.0 0.0 7 5.9 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain Peptidase_C26 PF07722.11 NM_001080809.2_1 - 0.15 11.7 0.0 0.4 10.3 0.0 1.8 1 1 0 1 1 1 0 Peptidase C26 Keratin_B2_2 PF13885.4 NM_001162944.1_1 - 2.1e-21 75.4 283.0 6.5e-06 25.9 58.2 5.7 1 1 3 5 5 5 5 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_001162944.1_1 - 0.23 11.3 206.6 1.8 8.4 73.3 4.3 1 1 2 3 3 3 0 Keratin, high sulfur B2 protein ARID PF01388.19 NM_001252622.1_2 - 1.3e-19 70.5 0.0 2.1e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-C2H2 PF00096.24 NM_144789.2_1 - 1.2e-41 138.7 138.8 1.4e-05 25.2 1.1 17.6 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_144789.2_1 - 3.6e-38 126.8 134.4 0.0022 18.5 1.1 18.1 18 0 0 18 18 17 16 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_144789.2_1 - 1.7e-25 88.1 114.7 2.4e-05 24.4 0.5 17.0 17 0 0 17 17 17 9 Zinc-finger double domain zf-C2H2_jaz PF12171.6 NM_144789.2_1 - 2e-11 43.8 95.7 0.01 16.0 0.1 16.7 18 0 0 18 18 18 9 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_144789.2_1 - 5.2e-09 36.1 108.7 0.098 12.9 0.4 16.4 17 0 0 17 17 17 9 Zinc-finger of C2H2 type SET PF00856.26 NM_144789.2_1 - 0.022 15.0 0.1 0.1 12.8 0.0 2.2 3 0 0 3 3 3 0 SET domain zf-C2HC_2 PF13913.4 NM_144789.2_1 - 0.046 13.5 0.2 0.046 13.5 0.2 10.8 12 0 0 12 12 12 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.4 NM_144789.2_1 - 0.1 12.5 111.1 0.79 9.6 0.9 16.7 17 0 0 17 17 17 0 C2H2-type zinc finger GAGA PF09237.9 NM_144789.2_1 - 0.52 10.0 3.1 18 5.1 0.0 3.6 3 0 0 3 3 3 0 GAGA factor Vps36-NZF-N PF16988.3 NM_144789.2_1 - 2 7.7 11.4 4.6 6.6 0.0 5.0 4 0 0 4 4 4 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zinc_ribbon_15 PF17032.3 NM_144789.2_1 - 4 8.1 67.7 1.8 9.2 1.6 8.9 6 2 4 10 10 9 0 zinc-ribbon family V-set PF07686.15 NM_001111094.1_2 - 4.2e-16 58.9 0.0 1.3e-15 57.4 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.14 NM_001111094.1_2 - 1e-09 38.2 0.0 1.1e-05 25.2 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001111094.1_2 - 3.1e-09 37.2 0.0 2.1e-05 24.9 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain SPRY PF00622.26 NM_001111094.1_2 - 3.5e-07 30.2 0.0 6.1e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 SPRY domain ig PF00047.23 NM_001111094.1_2 - 0.00035 20.5 0.0 0.0088 16.1 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 NM_001111094.1_2 - 0.00069 19.5 0.1 0.0025 17.7 0.0 2.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.9 NM_001111094.1_2 - 0.049 13.5 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain Rad51 PF08423.9 NM_011235.4_2 - 7.9e-25 87.4 0.1 1.2e-24 86.9 0.1 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 NM_011235.4_2 - 1.8e-10 40.6 0.5 2.8e-10 40.0 0.5 1.2 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.13 NM_011235.4_2 - 3.1e-09 36.4 0.2 7.9e-09 35.0 0.2 1.5 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.11 NM_011235.4_2 - 2.6e-08 33.4 0.1 4.5e-08 32.6 0.1 1.3 1 0 0 1 1 1 1 KaiC RecA PF00154.19 NM_011235.4_2 - 0.0013 18.1 1.5 0.096 12.0 0.1 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein HHH_5 PF14520.4 NM_011235.4_2 - 0.0053 17.2 0.5 4.6 7.8 0.1 2.4 2 0 0 2 2 2 2 Helix-hairpin-helix domain AAA_24 PF13479.4 NM_011235.4_2 - 0.006 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 NM_011235.4_2 - 0.0084 16.2 0.1 0.015 15.4 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.12 NM_011235.4_2 - 0.012 15.5 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.4 NM_011235.4_2 - 0.016 15.4 0.1 0.027 14.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain SIT PF15330.4 NM_019436.3_1 - 4.7e-05 23.6 0.0 0.00018 21.7 0.0 1.9 1 1 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT V-set PF07686.15 NM_054059.1_1 - 4.1e-61 203.8 0.0 2.8e-10 40.2 0.0 6.9 6 1 0 6 6 6 6 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_054059.1_1 - 7.3e-36 122.5 0.1 1.9e-09 37.8 0.1 6.6 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 NM_054059.1_1 - 4.4e-29 100.3 0.0 3.1e-09 36.7 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin I-set domain ig PF00047.23 NM_054059.1_1 - 1.1e-21 76.7 7.6 4.5e-10 39.4 0.2 6.5 6 0 0 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.4 NM_054059.1_1 - 4.9e-18 65.1 2.2 1.5e-07 31.5 0.3 7.2 7 3 0 7 7 7 5 Immunoglobulin domain Receptor_2B4 PF11465.6 NM_054059.1_1 - 1.8e-10 40.8 0.1 1.1 9.3 0.0 6.1 6 0 0 6 6 6 3 Natural killer cell receptor 2B4 Herpes_gE PF02480.14 NM_054059.1_1 - 1.1e-05 24.3 0.6 6.4 5.3 0.0 5.0 5 0 0 5 5 5 2 Alphaherpesvirus glycoprotein E Izumo-Ig PF16706.3 NM_054059.1_1 - 0.00041 20.2 0.8 0.02 14.8 0.0 3.7 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain CreA PF05981.10 NM_054059.1_1 - 0.012 15.5 0.0 7.2 6.5 0.0 2.8 3 0 0 3 3 3 0 CreA protein VWA_N PF08399.9 NM_054059.1_1 - 0.084 13.2 0.1 94 3.4 0.0 3.6 4 0 0 4 4 4 0 VWA N-terminal Pkinase PF00069.23 NM_020021.2_2 - 6.7e-42 143.5 0.0 9.6e-42 143.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_020021.2_2 - 1.1e-39 136.1 0.0 1.4e-39 135.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ion_trans PF00520.29 NM_177866.4_2 - 7.5e-32 110.4 25.2 9.4e-32 110.0 25.2 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.10 NM_177866.4_2 - 1.2e-05 24.1 9.8 1.2e-05 24.1 9.8 2.0 1 1 1 2 2 2 1 Polycystin cation channel TNFR_c6 PF00020.16 NM_011609.4_2 - 1.1e-21 76.8 58.6 1.5e-08 34.8 8.1 4.6 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Death PF00531.20 NM_011609.4_2 - 3.2e-14 52.7 0.0 5.2e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Death domain MAGE PF01454.17 NM_028025.1_1 - 4e-13 49.4 0.1 2.4e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 MAGE family DUF3098 PF11297.6 NM_028025.1_1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) Spore_coat_CotO PF14153.4 NM_028025.1_1 - 0.15 11.8 2.1 0.24 11.2 2.1 1.3 1 0 0 1 1 1 0 Spore coat protein CotO C2 PF00168.28 NM_001289586.1_3 - 6.8e-36 122.6 0.7 1.4e-20 73.4 0.6 2.2 2 0 0 2 2 2 2 C2 domain DSPc PF00782.18 NM_001166389.1_2 - 7.3e-06 25.7 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 NM_001166389.1_2 - 1.3e-05 24.7 0.0 1.9e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Tubulin PF00091.23 NM_001199047.1_2 - 2.2e-58 197.6 0.4 3e-58 197.2 0.4 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.4 NM_001199047.1_2 - 0.002 17.2 0.0 0.0032 16.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Glycos_transf_2 PF00535.24 NM_008081.3_3 - 2.3e-17 63.2 0.0 4.2e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Herpes_gE PF02480.14 NM_177648.3_3 - 0.022 13.4 0.0 0.036 12.7 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Dynein_light PF01221.16 NM_001168472.1_2 - 4.5e-42 142.1 2.1 7.7e-42 141.4 2.1 1.4 1 0 0 1 1 1 1 Dynein light chain type 1 7tm_4 PF13853.4 NM_146497.1_1 - 2.8e-49 168.2 20.0 3.4e-49 167.9 20.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146497.1_1 - 6.9e-19 68.0 22.1 1.3e-18 67.1 22.1 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Phage_holin_3_7 PF05449.9 NM_146497.1_1 - 0.11 12.3 4.0 5.8 6.8 0.4 2.7 2 1 0 2 2 2 0 Putative 3TM holin, Phage_holin_3 Pyr_redox_dim PF02852.20 NM_001178060.1_2 - 7.4e-29 100.1 0.0 1.6e-28 99.0 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.12 NM_001178060.1_2 - 2.5e-26 92.5 0.3 4.3e-12 45.7 0.1 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Glutaredoxin PF00462.22 NM_001178060.1_2 - 1e-15 57.5 0.1 3.3e-15 55.9 0.1 1.9 1 0 0 1 1 1 1 Glutaredoxin FAD_binding_2 PF00890.22 NM_001178060.1_2 - 8.8e-07 28.2 0.1 1.6e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.12 NM_001178060.1_2 - 0.0001 21.0 0.2 0.0007 18.3 0.2 2.1 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.22 NM_001178060.1_2 - 0.00014 21.4 0.1 0.00065 19.3 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.15 NM_001178060.1_2 - 0.00019 20.7 0.0 0.00031 19.9 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.5 NM_001178060.1_2 - 0.0025 17.1 0.1 0.0036 16.6 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.4 NM_001178060.1_2 - 0.0026 16.9 1.6 0.071 12.2 0.7 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 NM_001178060.1_2 - 0.0057 16.7 0.3 0.014 15.5 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.20 NM_001178060.1_2 - 0.0058 15.6 0.6 0.0086 15.1 0.6 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.19 NM_001178060.1_2 - 0.0091 15.2 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.25 NM_001178060.1_2 - 0.023 15.1 0.2 0.055 13.9 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.10 NM_001178060.1_2 - 0.13 11.1 0.2 0.19 10.6 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein SPATA6 PF14909.4 NM_026470.3_3 - 4.1e-53 179.2 0.0 5.9e-53 178.6 0.0 1.2 1 0 0 1 1 1 1 Spermatogenesis-assoc protein 6 Ribosomal_S16 PF00886.17 NM_025440.2_3 - 6e-23 80.5 0.0 1.7e-22 79.1 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S16 FtsK_4TM PF13491.4 NM_025440.2_3 - 0.066 12.8 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 4TM region of DNA translocase FtsK/SpoIIIE Cor1 PF04803.10 NM_031493.1_1 - 6.3e-30 104.0 7.9 6.3e-30 104.0 7.9 1.6 2 0 0 2 2 2 1 Cor1/Xlr/Xmr conserved region PLC-beta_C PF08703.8 NM_031493.1_1 - 0.049 13.5 0.4 0.049 13.5 0.4 3.2 3 1 1 4 4 4 0 PLC-beta C terminal APG17 PF04108.10 NM_031493.1_1 - 0.12 11.4 7.2 0.69 8.8 6.9 2.3 1 1 1 2 2 2 0 Autophagy protein Apg17 Pkinase PF00069.23 NM_001112711.2_2 - 2.3e-68 230.3 0.0 2.9e-68 229.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001112711.2_2 - 3.7e-35 121.3 0.0 6e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 NM_001112711.2_2 - 2.2e-18 66.5 0.1 4.9e-18 65.4 0.0 1.6 2 0 0 2 2 2 1 Regulator of G protein signaling domain Kinase-like PF14531.4 NM_001112711.2_2 - 0.0002 20.7 0.0 0.00033 19.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Integrin_alpha2 PF08441.10 NM_001253874.1_3 - 1e-42 146.5 0.0 1.5e-42 145.9 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 NM_001253874.1_3 - 1.4e-30 106.8 1.0 1.9e-30 106.3 1.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 NM_001253874.1_3 - 1.2e-14 54.0 7.9 2.3e-07 30.7 0.1 4.0 4 0 0 4 4 4 3 FG-GAP repeat VWA_2 PF13519.4 NM_001253874.1_3 - 3.9e-08 33.8 0.0 7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 NM_001253874.1_3 - 5.3e-05 23.6 0.0 0.019 15.4 0.0 2.8 2 1 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 NM_001253874.1_3 - 0.00011 22.3 9.2 0.038 14.1 0.3 4.5 4 0 0 4 4 4 2 FG-GAP repeat Integrin_alpha PF00357.18 NM_001253874.1_3 - 0.00044 19.9 0.4 0.00044 19.9 0.4 1.9 2 0 0 2 2 2 1 Integrin alpha cytoplasmic region Xlink PF00193.15 NM_053247.4_2 - 7.7e-19 67.8 0.1 1.3e-18 67.0 0.1 1.4 1 0 0 1 1 1 1 Extracellular link domain DUF2664 PF10867.6 NM_053247.4_3 - 0.08 13.3 0.8 0.93 9.8 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2664) G-patch PF01585.21 NM_026367.4_3 - 2.4e-16 59.2 1.6 4.4e-16 58.4 1.6 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 NM_026367.4_3 - 1.4e-07 31.4 0.2 3.6e-07 30.0 0.2 1.6 1 0 0 1 1 1 1 G-patch domain LCE PF14672.4 NM_027137.2_1 - 1.8e-12 47.6 126.2 4.8e-06 27.0 66.5 4.7 2 1 1 3 3 3 2 Late cornified envelope JmjC PF02373.20 NM_001205044.1_2 - 3.5e-34 117.6 1.7 6.8e-34 116.6 0.5 2.2 2 0 0 2 2 2 1 JmjC domain, hydroxylase ARID PF01388.19 NM_001205044.1_2 - 3.3e-13 50.0 0.0 8.5e-13 48.6 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.15 NM_001205044.1_2 - 4.5e-13 48.8 0.1 1.3e-12 47.3 0.1 1.8 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.14 NM_001205044.1_2 - 2.9e-08 33.8 8.8 6.7e-08 32.6 7.0 2.6 2 0 0 2 2 2 1 C5HC2 zinc finger fn3 PF00041.19 NM_001083934.1_3 - 5.8e-80 263.6 1.3 3.9e-17 62.3 0.1 6.2 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.14 NM_001083934.1_3 - 2.8e-76 251.5 7.5 1.9e-22 79.0 0.0 7.8 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001083934.1_3 - 5.2e-48 161.4 4.3 1e-10 41.9 0.1 7.8 7 0 0 7 7 7 6 Immunoglobulin domain Ig_2 PF13895.4 NM_001083934.1_3 - 2.8e-37 126.8 7.1 4.2e-09 36.5 0.0 7.9 8 0 0 8 8 8 5 Immunoglobulin domain ig PF00047.23 NM_001083934.1_3 - 3.2e-22 78.4 12.9 0.00036 20.5 0.1 8.3 8 0 0 8 8 8 6 Immunoglobulin domain V-set PF07686.15 NM_001083934.1_3 - 9.7e-19 67.4 19.4 0.0024 17.9 0.0 10.8 7 4 2 9 9 9 5 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.3 NM_001083934.1_3 - 6.4e-12 45.8 6.7 0.14 12.6 0.0 6.9 6 0 0 6 6 5 4 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.10 NM_001083934.1_3 - 8.1e-11 41.7 3.9 0.016 15.1 0.0 5.1 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain Tissue_fac PF01108.15 NM_001083934.1_3 - 2.3e-08 33.7 0.0 0.18 11.5 0.0 4.5 4 0 0 4 4 4 3 Tissue factor C1-set PF07654.13 NM_001083934.1_3 - 4.1e-07 30.2 5.0 0.23 11.8 0.0 5.6 6 0 0 6 6 6 2 Immunoglobulin C1-set domain BiPBP_C PF06832.10 NM_001083934.1_3 - 0.03 14.2 0.1 12 5.8 0.0 4.3 4 0 0 4 4 4 0 Penicillin-Binding Protein C-terminus Family Izumo-Ig PF16706.3 NM_001083934.1_3 - 0.032 14.2 0.3 15 5.6 0.0 4.9 6 0 0 6 6 6 0 Izumo-like Immunoglobulin domain Jun PF03957.11 NM_008416.3_2 - 1.6e-77 260.4 3.0 2.6e-77 259.7 3.0 1.3 1 0 0 1 1 1 1 Jun-like transcription factor bZIP_1 PF00170.19 NM_008416.3_2 - 6.5e-18 64.5 12.8 1e-17 63.9 12.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_008416.3_2 - 2.3e-08 33.8 10.4 4.1e-08 33.0 10.4 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_008416.3_2 - 6.6e-08 32.8 6.3 1.2e-07 32.0 6.3 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Jnk-SapK_ap_N PF09744.7 NM_008416.3_2 - 0.021 14.9 0.7 0.033 14.3 0.7 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ZapB PF06005.10 NM_008416.3_2 - 0.026 14.8 0.9 0.026 14.8 0.9 1.7 2 0 0 2 2 2 0 Cell division protein ZapB MAD PF05557.11 NM_008416.3_2 - 0.12 10.6 3.9 0.16 10.1 3.9 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein 7tm_3 PF00003.20 NM_001104550.1_1 - 2.4e-57 194.3 24.7 4.1e-57 193.5 24.7 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001104550.1_1 - 2.1e-33 115.7 0.0 3.3e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001104550.1_1 - 2e-18 66.0 11.7 3.9e-18 65.0 11.7 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF3810 PF12725.5 NM_001104550.1_1 - 0.051 12.8 5.1 0.18 10.9 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) PQ-loop PF04193.12 NM_001164423.1_2 - 5.4e-11 42.0 1.3 1.5e-10 40.6 0.0 2.5 2 0 0 2 2 2 1 PQ loop repeat LPAM_1 PF08139.10 NM_001164423.1_2 - 1.5 9.3 8.1 0.13 12.7 1.1 2.7 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site LIM PF00412.20 NM_144862.3_1 - 5.7e-60 199.3 55.5 2.7e-14 53.0 5.0 5.4 5 0 0 5 5 5 5 LIM domain APOBEC_N PF08210.9 NM_001160415.1_2 - 3.9e-85 284.1 11.8 1.1e-54 184.9 3.9 2.2 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 NM_001160415.1_2 - 2.1e-52 174.8 0.8 2.1e-26 91.5 0.2 2.4 2 0 0 2 2 2 2 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 NM_001160415.1_2 - 6e-07 29.1 0.2 0.0044 16.7 0.1 2.3 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Toxin-deaminase PF14424.4 NM_001160415.1_2 - 0.0075 16.2 0.1 3.1 7.8 0.0 2.2 2 0 0 2 2 2 2 The BURPS668_1122 family of deaminases Hairy_orange PF07527.11 NM_001160415.1_2 - 0.068 13.3 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Hairy Orange MafB19-deam PF14437.4 NM_001160415.1_2 - 0.16 11.6 0.0 3.2 7.4 0.0 2.2 2 0 0 2 2 2 0 MafB19-like deaminase MFS_1 PF07690.14 NM_146232.1_3 - 6.7e-27 94.2 23.8 3.2e-15 55.8 5.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 NM_146232.1_3 - 8.7e-22 77.5 9.7 1.4e-21 76.8 9.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter SPC12 PF06645.11 NM_146232.1_3 - 1.1 9.3 5.5 2.4 8.2 0.4 3.3 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) AIG1 PF04548.14 NM_001243200.1_1 - 1.4e-16 60.4 14.0 1e-13 51.0 1.0 2.9 2 1 1 3 3 3 2 AIG1 family HAUS6_N PF14661.4 NM_001243200.1_1 - 0.0062 16.1 6.0 0.0062 16.1 6.0 1.5 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus AAA_16 PF13191.4 NM_001243200.1_1 - 0.081 13.2 0.5 0.2 11.9 0.5 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 NM_001243200.1_1 - 0.091 12.9 2.6 0.26 11.4 2.4 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.25 NM_001243200.1_1 - 0.34 11.3 2.1 0.87 10.0 2.1 1.7 1 1 0 1 1 1 0 ABC transporter AAA_17 PF13207.4 NM_001243200.1_1 - 2.8 8.2 5.8 5.9 7.2 4.0 2.0 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.23 NM_146087.2_2 - 7.8e-27 94.1 0.0 1e-26 93.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_146087.2_2 - 7.3e-14 51.5 0.0 9e-14 51.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Abhydrolase_3 PF07859.11 NM_001085504.1_1 - 7.4e-40 136.9 0.0 1.7e-27 96.6 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_001085504.1_1 - 0.074 12.4 0.0 0.27 10.6 0.0 1.8 2 0 0 2 2 2 0 Prolyl oligopeptidase family D123 PF07065.12 NM_133837.4_2 - 3.7e-106 354.6 0.3 4.3e-106 354.4 0.3 1.0 1 0 0 1 1 1 1 D123 DUF4343 PF14243.4 NM_133837.4_2 - 0.0014 18.7 0.0 0.0024 18.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4343) Reg_prop PF07494.9 NM_133837.4_2 - 0.15 12.2 0.1 0.54 10.5 0.1 2.0 1 0 0 1 1 1 0 Two component regulator propeller ADP_ribosyl_GH PF03747.12 NM_007414.3_3 - 3.3e-54 184.5 2.5 4e-54 184.2 2.5 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase API5 PF05918.9 NM_007466.3_3 - 2.1e-196 653.6 0.6 2.7e-196 653.3 0.6 1.0 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) HEAT_2 PF13646.4 NM_007466.3_3 - 0.00062 20.0 0.2 0.0017 18.6 0.1 1.7 2 0 0 2 2 2 1 HEAT repeats MMS19_N PF14500.4 NM_007466.3_3 - 0.028 13.9 0.8 0.066 12.6 0.8 1.7 1 1 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Dak2 PF02734.15 NM_007466.3_3 - 0.072 12.9 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 DAK2 domain Tektin PF03148.12 NM_027630.1_1 - 7e-16 57.8 10.6 9e-16 57.5 10.6 1.1 1 0 0 1 1 1 1 Tektin family CENP-K PF11802.6 NM_027630.1_1 - 7.7 5.9 13.8 0.96 8.8 3.5 2.1 1 1 0 2 2 2 0 Centromere-associated protein K Cation_efflux PF01545.19 NM_178651.4_3 - 4.1e-31 108.2 6.3 5.5e-31 107.7 6.3 1.2 1 0 0 1 1 1 1 Cation efflux family XPA_C PF05181.10 NM_178651.4_3 - 0.0022 17.8 0.0 0.0051 16.6 0.0 1.6 1 0 0 1 1 1 1 XPA protein C-terminus RapA_C PF12137.6 NM_178651.4_3 - 0.034 13.0 0.3 0.053 12.4 0.3 1.3 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal IncA PF04156.12 NM_178651.4_3 - 0.094 12.4 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 IncA protein ZT_dimer PF16916.3 NM_178651.4_3 - 0.14 12.1 0.9 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Dimerisation domain of Zinc Transporter EGF PF00008.25 NM_010415.2_2 - 0.00062 19.9 6.1 0.00062 19.9 6.1 2.5 3 0 0 3 3 3 1 EGF-like domain F-box-like PF12937.5 NM_001014395.2_2 - 7.2e-11 41.7 0.4 1.8e-10 40.4 0.4 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_001014395.2_2 - 8e-08 31.8 0.1 2.3e-07 30.4 0.1 1.9 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.3 NM_001014395.2_2 - 0.0025 17.5 0.3 0.0068 16.1 0.3 1.7 1 0 0 1 1 1 1 F-box Ras PF00071.20 NM_133685.2_2 - 4.9e-54 182.2 0.0 6.4e-54 181.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_133685.2_2 - 6.1e-34 116.7 0.0 1e-33 116.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_133685.2_2 - 1.3e-11 44.2 0.0 1.8e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 NM_133685.2_2 - 0.00017 21.4 0.0 0.72 9.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 NM_133685.2_2 - 0.0027 17.6 0.0 0.0042 17.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_133685.2_2 - 0.085 12.1 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Homeobox PF00046.27 NM_010057.2_2 - 1.7e-20 72.4 2.4 3e-20 71.6 2.4 1.4 1 0 0 1 1 1 1 Homeobox domain RskA PF10099.7 NM_010057.2_2 - 0.0035 17.5 5.8 0.0058 16.8 4.1 2.0 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Homeobox_KN PF05920.9 NM_010057.2_2 - 0.0061 16.3 0.0 0.018 14.8 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain PRIMA1 PF16101.3 NM_010057.2_2 - 0.2 11.6 13.2 0.56 10.1 13.2 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SARAF PF06682.10 NM_010057.2_2 - 0.7 9.4 13.7 1.1 8.7 13.7 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis CAP_N PF01213.17 NM_010057.2_2 - 1.9 7.8 20.0 0.064 12.6 12.6 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Cytochrom_B558a PF05038.11 NM_010057.2_2 - 9.4 5.6 7.7 15 4.9 7.7 1.2 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit DUF4603 PF15376.4 NM_010057.2_3 - 0.64 7.2 13.9 0.85 6.8 13.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) CCDC106 PF15794.3 NM_010057.2_3 - 0.75 9.3 7.4 1.2 8.7 7.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 FAM198 PF15051.4 NM_133187.3_1 - 2.8e-151 502.9 0.1 3.6e-151 502.5 0.1 1.1 1 0 0 1 1 1 1 FAM198 protein ARID PF01388.19 NM_001290726.1_1 - 4.9e-15 55.8 0.0 9.3e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Homeobox PF00046.27 NM_001177538.1_3 - 3.7e-31 106.6 9.3 2.1e-17 62.5 1.2 2.4 2 0 0 2 2 2 2 Homeobox domain Homeobox_KN PF05920.9 NM_001177538.1_3 - 2.2e-07 30.5 1.4 0.007 16.1 0.2 2.9 2 0 0 2 2 2 2 Homeobox KN domain CENP-B_N PF04218.11 NM_001177538.1_3 - 8.7e-05 21.9 0.6 0.0034 16.8 0.3 2.6 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain YdaS_antitoxin PF15943.3 NM_001177538.1_3 - 0.0027 17.4 0.0 0.26 11.0 0.0 2.3 2 0 0 2 2 2 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Phage_CII PF05269.9 NM_001177538.1_3 - 0.04 14.0 0.1 7.6 6.7 0.0 2.3 2 0 0 2 2 2 0 Bacteriophage CII protein HTH_23 PF13384.4 NM_001177538.1_3 - 0.052 13.2 0.9 1.9 8.2 0.1 2.5 2 0 0 2 2 2 0 Homeodomain-like domain HTH_26 PF13443.4 NM_001177538.1_3 - 0.054 13.8 0.0 5.2 7.4 0.0 2.3 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain Phage_CI_repr PF07022.11 NM_001177538.1_3 - 0.11 12.4 0.0 4.7 7.3 0.0 2.3 2 0 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain WD40 PF00400.30 NM_001170742.1_1 - 7.2e-12 45.5 22.0 0.00016 22.2 0.4 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat Zn_ribbon_17 PF17120.3 NM_001170742.1_1 - 4.7e-11 42.0 15.6 4.7e-11 42.0 15.6 2.6 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.3 NM_001170742.1_1 - 5.7e-07 29.7 6.9 5.7e-07 29.7 6.9 2.1 1 1 1 2 2 2 1 Zinc-ribbon like family RWD PF05773.20 NM_001170742.1_1 - 0.015 15.5 0.3 0.027 14.6 0.3 1.4 1 0 0 1 1 1 0 RWD domain HMG_box PF00505.17 NM_145711.4_2 - 4.9e-17 62.0 0.4 4.9e-17 62.0 0.4 2.1 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_145711.4_2 - 2.1e-11 44.1 0.6 4.2e-11 43.1 0.6 1.4 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.11 NM_145711.4_2 - 0.036 14.5 0.1 0.074 13.5 0.1 1.6 1 0 0 1 1 1 0 YABBY protein Mitofilin PF09731.7 NM_145711.4_2 - 0.28 9.8 5.0 0.39 9.3 5.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein adh_short PF00106.23 NM_027534.2_2 - 1.3e-56 191.0 0.1 1.7e-56 190.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_027534.2_2 - 2.5e-28 99.1 0.0 3.7e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_027534.2_2 - 1e-12 48.2 0.2 1.7e-12 47.5 0.2 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.4 NM_027534.2_2 - 0.012 15.4 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding Polysacc_synt_2 PF02719.13 NM_027534.2_2 - 0.062 12.3 0.4 0.088 11.8 0.4 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Cas9-BH PF16593.3 NM_001110100.2_1 - 1.1 8.9 6.1 2.5 7.8 6.1 1.6 1 0 0 1 1 1 0 Bridge helix of CRISPR-associated endonuclease Cas9 BEN PF10523.7 NM_001110100.2_2 - 2.9e-07 30.5 0.0 8.7e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 BEN domain DUF1845 PF08900.9 NM_001110100.2_2 - 0.03 13.9 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1845) IHABP4_N PF16174.3 NM_001113564.1_2 - 1.9e-37 129.3 8.5 1.9e-37 129.3 8.5 1.7 2 0 0 2 2 2 1 Intracellular hyaluronan-binding protein 4 N-terminal HABP4_PAI-RBP1 PF04774.13 NM_001113564.1_2 - 2.9e-32 111.8 9.9 2.9e-32 111.8 9.9 2.2 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family S36_mt PF10937.6 NM_025369.3_2 - 4.3e-06 28.2 0.2 8.7e-06 27.2 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial Amino_oxidase PF01593.22 NM_001177840.1_1 - 3.4e-30 105.6 2.4 9.6e-22 77.7 0.3 2.1 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 NM_001177840.1_1 - 7.8e-17 61.2 0.7 1.7e-16 60.1 0.7 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 NM_001177840.1_1 - 1.8e-07 31.0 0.1 2e-07 30.9 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 NM_001177840.1_1 - 2.7e-06 26.6 1.2 3.8e-06 26.1 1.2 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.5 NM_001177840.1_1 - 0.0004 19.7 1.0 0.00048 19.5 1.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 NM_001177840.1_1 - 0.00048 19.3 0.0 0.00069 18.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.17 NM_001177840.1_1 - 0.00049 19.4 0.7 0.00065 18.9 0.7 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.25 NM_001177840.1_1 - 0.00075 19.9 0.2 0.0025 18.2 0.4 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.15 NM_001177840.1_1 - 0.00095 18.3 0.1 0.0015 17.7 0.1 1.2 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.12 NM_001177840.1_1 - 0.0022 16.7 0.3 0.003 16.2 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.4 NM_001177840.1_1 - 0.003 16.7 0.1 0.0043 16.2 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 NM_001177840.1_1 - 0.0037 16.4 0.1 0.0053 15.9 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.20 NM_001177840.1_1 - 0.0067 15.4 0.3 0.0083 15.1 0.3 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Glu_dehyd_C PF16912.3 NM_001177840.1_1 - 0.009 15.4 0.0 0.012 14.9 0.0 1.1 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Shikimate_DH PF01488.18 NM_001177840.1_1 - 0.011 15.7 0.1 0.02 14.8 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.4 NM_001177840.1_1 - 0.027 14.4 0.4 0.041 13.8 0.4 1.2 1 0 0 1 1 1 0 FAD-NAD(P)-binding FMO-like PF00743.17 NM_001177840.1_1 - 0.029 12.7 0.0 0.039 12.3 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Lycopene_cycl PF05834.10 NM_001177840.1_1 - 0.061 12.2 0.6 0.084 11.8 0.6 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein MCRA PF06100.9 NM_001177840.1_1 - 0.067 11.8 0.0 0.083 11.5 0.0 1.2 1 0 0 1 1 1 0 MCRA family Trp_halogenase PF04820.12 NM_001177840.1_1 - 0.22 10.2 0.5 0.28 9.8 0.5 1.1 1 0 0 1 1 1 0 Tryptophan halogenase 7tm_4 PF13853.4 NM_001011754.2_1 - 4.3e-49 167.6 23.7 5.6e-49 167.2 23.7 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011754.2_1 - 9.6e-21 74.1 25.2 5.3e-20 71.6 25.3 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_001011754.2_1 - 0.21 11.0 4.7 8.4 5.9 1.6 2.8 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus DUF4592 PF15262.4 NM_138648.2_1 - 0.67 10.7 4.1 2 9.2 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4592) Lectin_C PF00059.19 NM_138648.2_2 - 4.7e-14 52.9 0.7 1.1e-13 51.8 0.0 2.0 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 NM_138648.2_2 - 1.7e-05 24.4 0.0 5.5e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Ly49 PF08391.8 NM_138648.2_2 - 0.001 19.2 17.0 0.014 15.6 5.2 2.6 2 0 0 2 2 2 2 Ly49-like protein, N-terminal region Snapin_Pallidin PF14712.4 NM_138648.2_2 - 0.056 13.8 32.2 0.2 12.0 5.1 3.4 1 1 2 3 3 3 0 Snapin/Pallidin HemX PF04375.12 NM_138648.2_2 - 0.057 12.6 33.6 0.59 9.2 14.9 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Oleosin PF01277.15 NM_138648.2_2 - 0.064 12.9 0.0 0.19 11.3 0.0 1.8 1 0 0 1 1 1 0 Oleosin Nup88 PF10168.7 NM_138648.2_2 - 4.1 4.9 33.9 7.1 4.2 33.9 1.3 1 0 0 1 1 1 0 Nuclear pore component DUF1664 PF07889.10 NM_138648.2_2 - 4.7 7.1 26.3 1.5 8.7 6.3 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) EF-hand_1 PF00036.30 NM_001004025.4_3 - 1.1e-23 80.8 12.2 8.8e-06 24.8 0.3 4.5 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.4 NM_001004025.4_3 - 7.4e-19 66.2 10.9 7.5e-05 22.0 0.5 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 NM_001004025.4_3 - 7.4e-18 64.7 6.2 2.3e-10 40.6 1.1 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 NM_001004025.4_3 - 9.7e-18 62.4 7.8 0.00021 20.9 0.3 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.4 NM_001004025.4_3 - 3.5e-11 42.6 10.4 0.029 14.0 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_001004025.4_3 - 0.0016 18.6 0.0 3 8.1 0.0 2.5 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_001004025.4_3 - 0.01 15.6 4.1 1.4 8.7 0.1 3.0 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF2363 PF10155.7 NM_028043.2_2 - 1.4e-54 183.5 6.3 2e-54 182.9 6.3 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2363) Fructosamin_kin PF03881.12 NM_181420.3_1 - 2.2e-76 256.7 0.0 4.1e-76 255.8 0.0 1.4 1 1 0 1 1 1 1 Fructosamine kinase APH PF01636.21 NM_181420.3_1 - 4.2e-10 39.8 0.0 6.6e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family PPTA PF01239.20 NM_008033.3_1 - 2.1e-47 157.5 19.1 1.3e-11 43.8 0.3 5.8 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat TPR_14 PF13428.4 NM_008033.3_1 - 0.14 12.9 0.9 5 8.1 0.3 3.5 2 1 2 4 4 4 0 Tetratricopeptide repeat CAP_N PF01213.17 NM_008033.3_1 - 0.18 11.1 8.9 0.39 10.0 8.9 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal MoaC PF01967.19 NM_028464.1_1 - 4.7e-47 159.2 3.5 6.9e-47 158.7 3.5 1.3 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.11 NM_028464.1_1 - 2.1e-41 140.7 0.0 3.2e-41 140.1 0.0 1.3 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.19 NM_028464.1_1 - 1.7e-31 109.7 0.1 2.7e-31 109.1 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.4 NM_028464.1_1 - 3e-07 30.7 0.0 5.6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.4 NM_028464.1_1 - 0.00034 20.6 0.0 0.00083 19.3 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain CH PF00307.29 NM_001247984.1_1 - 9.2e-89 292.8 2.7 1.6e-24 86.0 0.1 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.30 NM_001247984.1_1 - 4.5e-13 47.6 1.2 3e-06 26.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 NM_001247984.1_1 - 1.2e-09 38.3 0.1 3e-09 37.1 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_001247984.1_1 - 1.8e-09 36.7 0.7 5.3e-05 22.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 NM_001247984.1_1 - 1e-08 34.6 1.0 0.0022 17.6 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_001247984.1_1 - 1.3e-08 33.8 0.7 0.0032 16.8 0.1 2.8 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.6 NM_001247984.1_1 - 0.00025 20.7 0.0 0.00075 19.2 0.0 1.8 1 0 0 1 1 1 1 CAMSAP CH domain SPARC_Ca_bdg PF10591.7 NM_001247984.1_1 - 0.075 13.2 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region HpcH_HpaI PF03328.12 NM_029556.3_3 - 1.2e-48 165.0 0.0 1.6e-48 164.6 0.0 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.4 NM_029556.3_3 - 3.2e-11 42.8 0.1 1e-06 28.0 0.0 2.2 1 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold RRM_1 PF00076.20 NM_001270515.1_2 - 1.9e-18 65.9 0.1 3.4e-18 65.1 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 NM_001270515.1_2 - 0.0011 18.9 9.8 0.0011 18.9 9.8 5.0 5 1 1 6 6 6 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 NM_001270515.1_2 - 0.0029 17.6 0.0 0.0064 16.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.4 NM_001270515.1_2 - 0.014 14.8 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PX PF00787.22 NM_080557.2_3 - 3.7e-23 81.5 0.2 7.6e-23 80.5 0.2 1.5 1 0 0 1 1 1 1 PX domain Vps5 PF09325.8 NM_080557.2_3 - 6.9e-05 22.4 10.6 0.0078 15.6 10.6 2.1 1 1 0 1 1 1 1 Vps5 C terminal like FlgM PF04316.11 NM_080557.2_3 - 0.098 12.9 0.2 0.23 11.7 0.2 1.6 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM Peptidase_C1 PF00112.21 NM_009982.5_2 - 5e-60 203.2 0.1 7.3e-60 202.7 0.1 1.2 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.9 NM_009982.5_2 - 2.8e-45 153.4 0.6 4.5e-45 152.7 0.6 1.3 1 0 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.13 NM_009982.5_2 - 0.0018 17.0 0.1 0.0085 14.8 0.0 1.8 2 0 0 2 2 2 1 Peptidase C1-like family BTB PF00651.29 NM_030251.3_1 - 6.1e-40 135.8 0.0 2.9e-19 69.2 0.0 3.2 2 1 1 3 3 3 3 BTB/POZ domain Ank_2 PF12796.5 NM_030251.3_1 - 1.8e-09 37.9 0.0 4.8e-09 36.5 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_030251.3_1 - 1.4e-07 31.8 0.0 4e-07 30.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_030251.3_1 - 1.9e-07 31.1 0.1 4.9e-07 29.8 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_030251.3_1 - 1.7e-06 27.8 0.1 0.0029 17.8 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.28 NM_030251.3_1 - 0.00038 20.6 0.0 0.007 16.6 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat BACK PF07707.13 NM_030251.3_1 - 0.00088 19.2 0.1 0.0025 17.7 0.1 1.8 1 0 0 1 1 1 1 BTB And C-terminal Kelch Lectin_C PF00059.19 NM_175526.3_1 - 1.2e-13 51.6 1.6 1.2e-13 51.6 1.6 2.2 2 0 0 2 2 2 1 Lectin C-type domain IncA PF04156.12 NM_175526.3_1 - 0.035 13.8 1.3 0.063 12.9 1.3 1.3 1 0 0 1 1 1 0 IncA protein Ly49 PF08391.8 NM_175526.3_1 - 0.044 14.0 7.2 0.26 11.5 7.2 2.1 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region DAG1 PF05454.9 NM_001276492.1_2 - 1.2e-155 517.0 6.3 1.7e-155 516.5 6.3 1.2 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) TMEM154 PF15102.4 NM_001276492.1_2 - 0.0024 17.7 0.0 0.0057 16.4 0.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family Ion_trans PF00520.29 NM_001168564.1_1 - 9.8e-46 155.8 0.4 1.4e-45 155.3 0.4 1.3 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_001168564.1_1 - 4.9e-31 106.8 1.4 1.2e-30 105.6 0.2 2.2 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_001168564.1_1 - 2.5e-11 43.3 3.9 6.9e-11 41.8 3.9 1.8 1 0 0 1 1 1 1 Ion channel BTB_3 PF16017.3 NM_001168564.1_1 - 0.047 13.7 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain 7tm_4 PF13853.4 NM_147046.2_1 - 1.1e-96 323.7 24.9 1.4e-96 323.4 24.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147046.2_1 - 2.7e-13 49.6 24.3 6.6e-13 48.4 24.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147046.2_1 - 2.8e-11 43.1 15.9 2.8e-11 43.1 15.9 1.8 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_147046.2_1 - 0.00032 20.0 15.0 0.00032 20.0 15.0 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2618 PF10940.6 NM_147046.2_3 - 0.06 13.0 2.6 0.13 12.0 2.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2618) dCMP_cyt_deam_1 PF00383.21 NM_025748.4_3 - 3.1e-20 71.8 2.3 5.1e-20 71.1 2.3 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 NM_025748.4_3 - 5.7e-20 71.3 0.1 8.3e-20 70.8 0.1 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.4 NM_025748.4_3 - 0.023 14.6 2.8 0.13 12.2 2.8 1.9 1 1 0 1 1 1 0 Bd3614-like deaminase XOO_2897-deam PF14440.4 NM_025748.4_3 - 0.065 13.2 0.3 0.16 11.9 0.1 1.7 2 0 0 2 2 2 0 Xanthomonas XOO_2897-like deaminase ATP-synt_C PF00137.19 NM_175015.3_2 - 3.5e-11 43.1 12.4 6.1e-11 42.4 12.4 1.4 1 0 0 1 1 1 1 ATP synthase subunit C DUF3499 PF12005.6 NM_175015.3_2 - 0.1 13.0 0.2 0.18 12.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) V1R PF03402.12 NM_134210.1_1 - 4.5e-29 101.8 22.3 4.5e-29 101.8 22.3 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_134210.1_1 - 4.4e-10 39.0 26.8 5.7e-10 38.7 26.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2985 PF11204.6 NM_134210.1_1 - 4.9 7.2 9.5 9.3 6.4 0.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2985) NTR PF01759.19 NM_001033356.3_3 - 4.3e-23 81.0 0.0 7.1e-23 80.3 0.0 1.4 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Laminin_EGF PF00053.22 NM_001033356.3_3 - 3.3e-11 43.0 44.4 1.2e-08 34.8 14.3 3.2 3 0 0 3 3 3 2 Laminin EGF domain Laminin_N PF00055.15 NM_001033356.3_3 - 0.0045 16.5 0.1 0.024 14.1 0.0 2.2 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) VPS9 PF02204.16 NM_001310661.1_2 - 3.8e-25 88.0 0.2 6.2e-24 84.1 0.0 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain MIT PF04212.16 NM_001310661.1_2 - 1.3e-05 25.1 0.1 4.9e-05 23.2 0.1 2.1 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Transglut_C PF00927.20 NM_001289747.1_1 - 2e-41 140.3 0.4 2e-20 72.8 0.0 2.4 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.18 NM_001289747.1_1 - 3.4e-31 107.9 0.0 9.2e-31 106.5 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.17 NM_001289747.1_1 - 2.6e-16 59.9 0.3 4.9e-16 59.0 0.3 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Pkinase PF00069.23 NM_146244.4_3 - 5e-27 94.8 0.0 8.3e-25 87.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain MIT PF04212.16 NM_146244.4_3 - 4.4e-15 55.4 0.1 7.5e-15 54.6 0.1 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Pkinase_Tyr PF07714.15 NM_146244.4_3 - 7.1e-11 41.7 0.0 1.2e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_146244.4_3 - 0.082 12.1 0.1 0.12 11.5 0.1 1.2 1 0 0 1 1 1 0 Kinase-like KAR9 PF08580.8 NM_146244.4_3 - 0.54 8.6 1.2 0.75 8.1 1.2 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 V1R PF03402.12 NM_134193.2_1 - 1.8e-29 103.1 14.1 2.6e-29 102.5 14.1 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_134193.2_1 - 7.1e-07 28.5 18.6 9.6e-07 28.1 18.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_134193.2_1 - 9.3e-07 28.2 14.3 1.4e-06 27.6 14.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2304 PF10066.7 NM_134193.2_1 - 0.03 14.4 11.6 0.35 11.0 0.1 4.0 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2304) DUF4131 PF13567.4 NM_134193.2_1 - 0.68 9.4 4.5 6.5 6.2 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) HMG_box_2 PF09011.8 NM_178277.1_1 - 2.2e-11 44.0 0.3 4.5e-11 43.1 0.3 1.5 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.17 NM_178277.1_1 - 1.2e-10 41.5 0.4 3.2e-10 40.2 0.4 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box DUF4712 PF15830.3 NM_053216.2_1 - 9.3e-134 444.8 1.7 1.1e-133 444.6 1.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4712) PAX PF00292.16 NM_008782.2_3 - 1.9e-74 247.4 0.7 3.3e-74 246.6 0.7 1.4 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 NM_008782.2_3 - 3.3e-50 168.8 14.4 3.3e-50 168.8 14.4 1.9 2 0 0 2 2 2 1 Paired-box protein 2 C terminal HTH_32 PF13565.4 NM_008782.2_3 - 3.9e-06 27.2 0.2 0.0028 18.1 0.0 2.4 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.4 NM_008782.2_3 - 7.2e-05 22.3 0.0 0.00023 20.7 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.4 NM_008782.2_3 - 0.015 15.3 0.0 0.033 14.2 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Ribosomal_S13_N PF08069.10 NM_008782.2_3 - 0.053 13.4 0.1 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain HTH_Tnp_IS1 PF12759.5 NM_008782.2_3 - 0.065 12.7 0.2 0.19 11.2 0.0 1.9 2 0 0 2 2 2 0 InsA C-terminal domain Homeobox PF00046.27 NM_008782.2_3 - 0.11 12.2 0.1 0.28 10.9 0.1 1.7 1 0 0 1 1 1 0 Homeobox domain Zona_pellucida PF00100.21 NM_177465.4_3 - 5.7e-40 137.5 5.4 5.7e-40 137.5 5.4 2.1 2 0 0 2 2 2 1 Zona pellucida-like domain EGF_CA PF07645.13 NM_177465.4_3 - 1.2e-14 54.1 45.3 3e-07 30.4 4.0 4.2 4 0 0 4 4 4 3 Calcium-binding EGF domain SEA PF01390.18 NM_177465.4_3 - 1.1e-10 41.6 4.0 0.00021 21.4 0.2 2.9 3 0 0 3 3 3 2 SEA domain fn3 PF00041.19 NM_177465.4_3 - 1.5e-09 37.9 0.3 0.00083 19.5 0.0 3.1 2 0 0 2 2 2 2 Fibronectin type III domain WAP PF00095.19 NM_177465.4_3 - 9e-07 29.1 8.4 9e-07 29.1 8.4 3.7 4 0 0 4 4 4 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' EGF_3 PF12947.5 NM_177465.4_3 - 1.1e-06 28.6 27.0 0.00013 22.0 5.1 3.8 3 0 0 3 3 3 3 EGF domain hEGF PF12661.5 NM_177465.4_3 - 0.00071 20.0 22.9 0.024 15.2 2.2 4.0 3 0 0 3 3 3 2 Human growth factor-like EGF fn3_2 PF16893.3 NM_177465.4_3 - 0.0014 18.6 0.2 0.097 12.7 0.0 3.5 3 0 0 3 3 3 1 Fibronectin type III domain TPR_2 PF07719.15 NM_026213.3_1 - 2.2e-08 33.5 0.3 0.0026 17.6 0.2 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_026213.3_1 - 1e-05 25.8 0.9 0.16 12.7 0.1 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 NM_026213.3_1 - 1.4e-05 24.6 0.1 0.15 11.8 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 NM_026213.3_1 - 3.1e-05 23.4 0.0 0.0012 18.4 0.1 2.3 2 0 0 2 2 2 1 TPR repeat TPR_16 PF13432.4 NM_026213.3_1 - 8.3e-05 23.1 0.1 0.042 14.4 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_026213.3_1 - 9.9e-05 22.3 0.2 0.0031 17.5 0.0 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_026213.3_1 - 0.00084 19.7 0.1 0.31 11.5 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_026213.3_1 - 0.014 15.6 0.6 1.5 9.2 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat ChAPs PF09295.8 NM_026213.3_1 - 0.018 13.9 0.2 0.026 13.4 0.2 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) Fox-1_C PF12414.6 NM_001039167.1_2 - 9.9e-36 121.8 22.7 2.8e-19 69.1 4.3 2.9 2 0 0 2 2 2 2 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 NM_001039167.1_2 - 2.6e-18 65.5 0.1 4.4e-18 64.7 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001039167.1_2 - 0.089 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) THAP PF05485.10 NM_001145929.1_1 - 7.3e-17 62.0 4.7 1.4e-16 61.1 4.7 1.5 1 0 0 1 1 1 1 THAP domain GlcNAc_2-epim PF07221.9 NM_023132.3_3 - 2.3e-44 151.9 0.0 3.7e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) WD40 PF00400.30 NM_013530.1_3 - 4.4e-39 131.6 25.0 1.3e-07 32.0 0.1 7.7 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_013530.1_3 - 6.7e-14 51.8 0.0 0.0019 18.3 0.1 5.5 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_013530.1_3 - 5.3e-06 26.3 0.0 0.34 10.6 0.0 3.0 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.3 NM_013530.1_3 - 0.00024 20.4 0.0 0.0013 18.0 0.0 2.1 2 1 0 2 2 2 1 WD40-like domain Toxin_GhoT_OrtT PF10753.7 NM_001172095.1_1 - 0.012 15.7 1.9 0.027 14.6 1.9 1.6 1 0 0 1 1 1 0 Toxin GhoT_OrtT JmjC PF02373.20 NM_001172095.1_3 - 6.9e-44 148.8 0.1 1.6e-43 147.6 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.4 NM_001172095.1_3 - 3.6e-35 120.3 8.3 3.6e-35 120.3 8.3 2.4 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 NM_001172095.1_3 - 6.2e-18 64.7 2.4 6.2e-18 64.7 2.4 3.5 3 1 1 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.4 NM_001172095.1_3 - 1.1e-12 47.1 7.6 1.1e-12 47.1 7.6 2.7 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.15 NM_001172095.1_3 - 5.6e-12 45.3 0.0 1.5e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 jmjN domain LBR_tudor PF09465.8 NM_001172095.1_3 - 1.4e-05 24.7 1.8 0.0055 16.4 0.2 2.6 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain PHD PF00628.27 NM_001172095.1_3 - 7.1e-05 22.5 2.8 7.1e-05 22.5 2.8 3.1 3 0 0 3 3 3 2 PHD-finger 53-BP1_Tudor PF09038.8 NM_001172095.1_3 - 0.0058 16.4 0.3 3.7 7.4 0.0 2.5 1 1 1 2 2 2 2 Tumour suppressor p53-binding protein-1 Tudor G-patch_2 PF12656.5 NM_173747.3_3 - 1.8e-20 72.7 0.3 3.8e-20 71.6 0.3 1.5 1 0 0 1 1 1 1 G-patch domain KOW PF00467.27 NM_173747.3_3 - 5.8e-10 38.7 0.8 3.3e-05 23.6 0.1 2.4 2 0 0 2 2 2 2 KOW motif G-patch PF01585.21 NM_173747.3_3 - 0.00017 21.3 1.1 0.00031 20.5 1.1 1.5 1 0 0 1 1 1 1 G-patch domain zf-H2C2_2 PF13465.4 NM_019941.2_3 - 1.6e-114 369.5 114.6 4.5e-10 39.4 0.5 17.0 16 0 0 16 16 16 15 Zinc-finger double domain zf-C2H2 PF00096.24 NM_019941.2_3 - 3.9e-76 247.3 123.5 4.2e-06 26.8 0.3 16.0 15 0 0 15 15 15 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_019941.2_3 - 4.8e-41 135.7 123.7 0.004 17.7 0.8 16.0 15 0 0 15 15 15 15 C2H2-type zinc finger KRAB PF01352.25 NM_019941.2_3 - 1.1e-18 66.5 0.2 2e-18 65.6 0.2 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_019941.2_3 - 3.2e-15 55.9 75.0 0.0021 18.2 0.1 14.7 15 0 0 15 15 14 7 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_019941.2_3 - 9e-11 41.6 83.2 0.0063 16.5 2.0 10.7 2 1 9 12 12 12 11 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_019941.2_3 - 2.9e-10 39.7 96.1 0.33 10.8 0.7 15.4 15 0 0 15 15 14 11 C2H2-type zinc finger zf-met PF12874.5 NM_019941.2_3 - 5.8e-07 29.6 113.8 0.005 17.1 0.6 15.0 15 0 0 15 15 15 10 Zinc-finger of C2H2 type XPA_N PF01286.16 NM_019941.2_3 - 0.0042 16.9 73.4 0.81 9.6 0.3 14.5 15 0 0 15 15 15 5 XPA protein N-terminal zf-trcl PF13451.4 NM_019941.2_3 - 0.061 13.1 0.1 0.061 13.1 0.1 12.6 9 3 3 12 12 12 0 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 NM_019941.2_3 - 0.09 13.4 62.5 0.52 11.0 1.8 8.5 1 1 10 11 11 11 0 zinc-ribbon family Scramblase PF03803.13 NM_019941.2_3 - 4.1 6.5 9.8 1.5 8.0 1.0 3.5 1 1 2 4 4 4 0 Scramblase SNCAIP_SNCA_bd PF16700.3 NM_001199151.1_1 - 3.5e-24 84.1 8.7 8.4e-24 82.9 8.7 1.7 1 0 0 1 1 1 1 Synphilin-1 alpha-Synuclein-binding domain Ank_2 PF12796.5 NM_001199151.1_1 - 2.5e-16 59.9 1.2 6.4e-07 29.7 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001199151.1_1 - 4.3e-15 55.7 0.4 3.1e-05 24.3 0.0 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 NM_001199151.1_1 - 1.1e-13 50.9 0.9 0.0012 19.1 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_001199151.1_1 - 1.1e-06 28.7 1.4 0.036 14.4 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 NM_001199151.1_1 - 7.7e-05 22.7 0.3 1 10.0 0.2 4.1 4 0 0 4 4 4 2 Ankyrin repeat Methyltransf_32 PF13679.4 NM_026231.2_3 - 9.5e-10 38.5 4.5 1.6e-08 34.6 4.5 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_026231.2_3 - 3.8e-08 33.1 0.0 2.2e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain TRM13 PF05206.12 NM_026231.2_3 - 1.2e-05 24.9 0.4 0.16 11.3 0.6 2.6 1 1 1 2 2 2 2 Methyltransferase TRM13 GidB PF02527.13 NM_026231.2_3 - 1.6e-05 24.2 0.0 2.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G GST_C_3 PF14497.4 NM_026231.2_3 - 6.4e-05 23.0 0.1 0.00023 21.1 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain MTS PF05175.12 NM_026231.2_3 - 0.00061 19.2 0.0 0.0012 18.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain GST_C_2 PF13410.4 NM_026231.2_3 - 0.0016 18.2 0.0 0.0045 16.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Methyltransf_25 PF13649.4 NM_026231.2_3 - 0.002 18.7 0.0 0.005 17.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 NM_026231.2_3 - 0.0086 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family GST_C PF00043.23 NM_026231.2_3 - 0.011 15.8 0.0 0.027 14.6 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Methyltransf_4 PF02390.15 NM_026231.2_3 - 0.011 15.1 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_16 PF10294.7 NM_026231.2_3 - 0.026 14.1 0.0 0.052 13.2 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Ion_trans PF00520.29 NM_001252060.1_3 - 5.9e-247 814.8 78.1 7e-68 228.3 0.5 4.2 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 NM_001252060.1_3 - 1.1e-37 127.6 0.0 3.8e-37 125.8 0.0 2.0 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 NM_001252060.1_3 - 7.8e-31 106.1 0.5 2.1e-30 104.7 0.5 1.8 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 NM_001252060.1_3 - 6.6e-06 24.9 7.6 6.6e-06 24.9 7.6 10.0 6 4 4 10 10 10 5 Polycystin cation channel Kinesin PF00225.21 NM_001109040.2_1 - 2.8e-108 361.6 0.3 2.8e-108 361.6 0.3 3.0 2 1 2 4 4 4 1 Kinesin motor domain WD40 PF00400.30 NM_001109040.2_1 - 1.5e-27 95.1 11.0 1.2e-05 25.8 0.4 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat Microtub_bd PF16796.3 NM_001109040.2_1 - 9.8e-25 87.1 0.0 9.8e-25 87.1 0.0 2.7 2 0 0 2 2 2 1 Microtubule binding Trypsin PF00089.24 NM_015779.2_3 - 2e-59 200.9 0.0 2.4e-59 200.7 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_015779.2_3 - 0.00063 20.5 0.1 0.001 19.8 0.1 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_015779.2_3 - 0.0043 17.3 0.0 0.0071 16.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Ank_2 PF12796.5 NM_145633.3_3 - 5.9e-65 215.7 20.1 3.1e-17 62.8 2.7 6.1 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.28 NM_145633.3_3 - 1.8e-49 163.9 21.8 1.1e-06 28.6 1.5 8.8 8 0 0 8 8 8 8 Ankyrin repeat Ank_4 PF13637.4 NM_145633.3_3 - 8e-46 153.7 18.2 1.2e-10 41.6 0.7 9.2 3 3 6 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_145633.3_3 - 7.1e-43 139.5 8.1 5.4e-05 23.2 0.2 9.8 9 0 0 9 9 9 9 Ankyrin repeat Ank_5 PF13857.4 NM_145633.3_3 - 8.5e-41 137.2 15.1 2.3e-09 37.2 0.1 9.1 3 2 6 9 9 9 8 Ankyrin repeats (many copies) VPS9 PF02204.16 NM_145633.3_3 - 4.9e-23 81.2 0.2 1.2e-22 79.9 0.2 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain PEGA PF08308.9 NM_145633.3_3 - 0.091 12.5 0.0 1.9 8.3 0.0 3.0 3 0 0 3 3 3 0 PEGA domain Ribonuc_red_sm PF00268.19 NM_145633.3_3 - 0.11 11.9 0.6 0.18 11.1 0.6 1.2 1 0 0 1 1 1 0 Ribonucleotide reductase, small chain KCNQ_channel PF03520.12 NM_001006674.2_3 - 2.3e-62 210.1 0.1 3.9e-62 209.3 0.1 1.3 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel Ion_trans PF00520.29 NM_001006674.2_3 - 1.5e-29 102.8 7.2 1.5e-29 102.8 7.2 1.5 2 0 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.14 NM_001006674.2_3 - 1.3e-12 47.4 3.3 1.3e-12 47.4 3.3 1.9 2 0 0 2 2 2 1 Ion channel YbhQ PF11076.6 NM_001006674.2_3 - 3.1 7.7 9.4 9.8 6.1 1.0 2.7 3 0 0 3 3 3 0 Putative inner membrane protein YbhQ Homeobox PF00046.27 NM_001039688.3_2 - 3.6e-10 39.4 8.1 5.5e-10 38.8 8.1 1.3 1 0 0 1 1 1 1 Homeobox domain YdaS_antitoxin PF15943.3 NM_001039688.3_2 - 0.087 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_Tnp_ISL3 PF13542.4 NM_001039688.3_2 - 0.1 11.9 0.4 0.24 10.7 0.4 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Helicase_C_2 PF13307.4 NM_001003919.1_1 - 3.8e-54 183.3 0.0 9.3e-54 182.0 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.13 NM_001003919.1_1 - 5.9e-52 175.7 0.1 1.2e-51 174.7 0.1 1.5 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.9 NM_001003919.1_1 - 0.0005 19.7 0.0 0.0014 18.2 0.0 1.7 1 0 0 1 1 1 1 Helical and beta-bridge domain ResIII PF04851.13 NM_001003919.1_1 - 0.0033 17.3 0.0 1.7 8.5 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.27 NM_001003919.1_1 - 0.0043 16.7 0.0 0.33 10.6 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.4 NM_001003919.1_1 - 0.12 12.6 0.9 2 8.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain p450 PF00067.20 NM_001252539.1_1 - 4.7e-17 61.8 0.1 6e-17 61.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 NM_001252539.1_3 - 1.7e-96 323.6 0.1 7e-95 318.3 0.1 2.0 1 1 0 1 1 1 1 Cytochrome P450 Ipi1_N PF12333.6 NM_172304.3_1 - 1.5e-21 76.7 0.6 1.5e-21 76.7 0.6 4.3 5 1 1 6 6 6 1 Rix1 complex component involved in 60S ribosome maturation Vac14_Fab1_bd PF12755.5 NM_172304.3_1 - 0.011 16.2 0.0 0.046 14.2 0.0 2.2 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region Sp38 PF07354.10 NM_001166495.1_3 - 4.3e-138 458.5 3.7 5.1e-138 458.3 3.7 1.0 1 0 0 1 1 1 1 Zona-pellucida-binding protein (Sp38) NCD3G PF07562.12 NM_001166495.1_3 - 0.16 11.9 4.9 0.34 10.8 4.9 1.6 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR IP_trans PF02121.16 NM_019640.5_1 - 3.9e-117 390.0 1.1 5.6e-117 389.5 1.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein RBD-FIP PF09457.8 NM_001003955.2_2 - 8.9e-10 38.2 2.8 1.7e-09 37.3 2.8 1.5 1 0 0 1 1 1 1 FIP domain C2 PF00168.28 NM_001003955.2_2 - 1.1e-09 38.4 0.0 6.9e-09 35.8 0.0 2.1 1 1 0 1 1 1 1 C2 domain Ets PF00178.20 NM_001302154.1_2 - 7.5e-36 122.3 0.5 1.5e-35 121.4 0.5 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 NM_001302154.1_2 - 2.8e-25 87.9 0.0 5.4e-25 87.0 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Crystall PF00030.17 NM_153076.2_1 - 7.1e-65 215.1 2.1 4.2e-32 110.1 0.1 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 NM_153076.2_1 - 9.3e-07 28.6 0.2 0.0075 16.1 0.0 2.7 2 1 1 3 3 3 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 NM_153076.2_1 - 0.058 13.4 0.5 0.8 9.8 0.1 2.5 3 0 0 3 3 3 0 Beta/Gamma crystallin Macro PF01661.19 NM_207000.2_1 - 5.2e-26 90.9 0.1 8.2e-26 90.2 0.1 1.3 1 0 0 1 1 1 1 Macro domain Histone_H2A_C PF16211.3 NM_207000.2_1 - 1.1e-16 60.1 0.8 1.1e-16 60.1 0.8 1.9 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.22 NM_207000.2_1 - 1.5e-12 47.9 8.5 1.5e-12 47.9 0.0 2.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_207000.2_1 - 0.003 17.7 0.0 0.0079 16.3 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Forkhead PF00250.16 NM_021899.3_1 - 1e-34 118.6 0.2 2.1e-34 117.5 0.2 1.5 1 0 0 1 1 1 1 Forkhead domain Neur_chan_memb PF02932.14 NM_145129.2_1 - 1.5e-92 309.8 3.4 2e-92 309.5 3.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 NM_145129.2_1 - 8.8e-75 250.7 4.6 1.2e-74 250.3 4.6 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF4772 PF15997.3 NM_199029.2_1 - 3e-27 95.4 0.0 5.6e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4772) PMG PF05287.10 NM_001113406.1_1 - 6.2e-26 91.4 48.6 6.2e-26 91.4 48.6 2.1 2 0 0 2 2 2 1 PMG protein WBP-1 PF11669.6 NM_001030296.4_2 - 8.3e-05 23.0 0.3 8.3e-05 23.0 0.3 3.0 3 0 0 3 3 3 1 WW domain-binding protein 1 HemY_N PF07219.11 NM_001030296.4_2 - 0.25 11.4 0.5 0.43 10.6 0.5 1.3 1 0 0 1 1 1 0 HemY protein N-terminus TMEM52 PF14979.4 NM_001030296.4_2 - 5.5 6.8 6.2 3.5 7.4 0.4 2.6 2 0 0 2 2 2 0 Transmembrane 52 DUF4722 PF15849.3 NM_026315.1_3 - 1.4e-92 307.8 0.1 1.9e-92 307.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4722) Trypsin PF00089.24 NM_027097.1_1 - 5e-68 229.1 1.5 5.8e-68 228.9 1.5 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_027097.1_1 - 4.8e-06 26.8 0.3 2.8e-05 24.3 0.3 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_027097.1_1 - 1.8e-05 25.5 0.1 2.9e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain PX PF00787.22 NM_001025612.2_1 - 5.3e-14 52.0 0.2 8e-14 51.5 0.2 1.2 1 0 0 1 1 1 1 PX domain FTO_NTD PF12933.5 NM_011936.2_1 - 7.5e-120 399.3 0.0 9.8e-120 399.0 0.0 1.1 1 0 0 1 1 1 1 FTO catalytic domain FTO_CTD PF12934.5 NM_011936.2_1 - 1.8e-62 209.9 0.5 3.1e-62 209.1 0.5 1.4 1 0 0 1 1 1 1 FTO C-terminal domain PRY PF13765.4 NM_001079932.3_2 - 1.8e-10 40.1 0.1 3.3e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 SPRY-associated domain zf-RING_UBOX PF13445.4 NM_001079932.3_2 - 4.9e-10 39.1 2.6 1.1e-09 38.0 2.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 NM_001079932.3_2 - 5.6e-10 39.1 9.0 5.6e-10 39.1 9.0 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 NM_001079932.3_2 - 4.1e-09 36.3 0.5 4.1e-09 36.3 0.5 2.8 4 0 0 4 4 2 1 B-box zinc finger SPRY PF00622.26 NM_001079932.3_2 - 1.5e-08 34.7 0.0 2.5e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 NM_001079932.3_2 - 1.8e-07 30.8 6.5 4e-07 29.7 6.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001079932.3_2 - 5.4e-06 26.0 8.5 1.6e-05 24.5 8.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_001079932.3_2 - 4.1e-05 23.6 8.2 4.1e-05 23.6 8.2 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 NM_001079932.3_2 - 0.00017 21.3 6.9 0.00017 21.3 6.9 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001079932.3_2 - 0.00034 20.4 7.4 0.00034 20.4 7.4 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-Nse PF11789.6 NM_001079932.3_2 - 0.0012 18.5 2.7 0.0022 17.6 2.7 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 NM_001079932.3_2 - 0.094 12.5 2.3 0.19 11.5 2.3 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein K-box PF01486.15 NM_001079932.3_2 - 0.13 12.3 4.0 0.21 11.6 4.0 1.3 1 0 0 1 1 1 0 K-box region Prok-RING_4 PF14447.4 NM_001079932.3_2 - 0.16 11.8 8.7 1.6 8.6 8.8 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 NM_001079932.3_2 - 0.31 10.7 6.7 1.2 8.8 6.7 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain HrpB7 PF09486.8 NM_001079932.3_2 - 0.55 10.5 6.6 1.7 8.9 6.6 1.7 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Spc7 PF08317.9 NM_001079932.3_2 - 3.3 6.4 5.7 5.3 5.7 5.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein zf-RING_10 PF16685.3 NM_001079932.3_2 - 8.4 6.5 11.7 0.27 11.3 4.4 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 DUF4713 PF15831.3 NM_001162998.1_3 - 0.015 15.6 0.0 0.023 15.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) CIMR PF00878.16 NM_010515.2_3 - 0 1309.3 82.2 2.3e-57 193.0 0.0 16.3 16 0 0 16 16 16 16 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.8 NM_010515.2_3 - 1.3e-61 208.7 72.0 7.5e-08 32.4 1.7 16.9 2 1 12 14 14 14 14 Autophagy-related protein 27 fn2 PF00040.17 NM_010515.2_3 - 1.5e-16 60.2 3.7 5.9e-16 58.3 3.7 2.2 1 0 0 1 1 1 1 Fibronectin type II domain Man-6-P_recep PF02157.13 NM_010515.2_3 - 2.2e-05 23.7 5.6 0.0015 17.7 0.2 4.0 4 0 0 4 4 4 2 Mannose-6-phosphate receptor PRKCSH_1 PF13015.4 NM_010515.2_3 - 0.00013 21.5 39.1 0.23 11.0 0.0 10.9 12 0 0 12 12 12 4 Glucosidase II beta subunit-like protein SRP-alpha_N PF04086.11 NM_026130.1_3 - 1.6e-65 221.8 2.6 2.2e-65 221.4 2.6 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.20 NM_026130.1_3 - 3.1e-47 160.6 0.5 1.3e-46 158.6 0.5 1.9 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.17 NM_026130.1_3 - 2.3e-08 34.0 0.1 6.8e-08 32.5 0.1 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain ArgK PF03308.14 NM_026130.1_3 - 1.4e-07 30.7 0.0 2.7e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 ArgK protein CbiA PF01656.21 NM_026130.1_3 - 0.0014 18.5 0.5 1.1 9.2 0.0 2.5 2 0 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.4 NM_026130.1_3 - 0.0086 16.3 0.1 0.023 15.0 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.4 NM_026130.1_3 - 0.021 14.4 0.1 0.039 13.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain PfkB PF00294.22 NM_026130.1_3 - 0.026 13.7 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 pfkB family carbohydrate kinase Fer4_NifH PF00142.16 NM_026130.1_3 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Mlf1IP PF10248.7 NM_001039543.2_3 - 1.7e-73 246.0 8.4 2.8e-73 245.3 8.4 1.3 1 0 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein IL8 PF00048.18 NM_021704.3_2 - 5e-07 29.6 1.4 1.3e-06 28.4 1.4 1.7 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like DC_STAMP PF07782.11 NM_001289508.1_1 - 8e-39 133.3 2.3 1.3e-33 116.3 0.3 2.8 1 1 1 2 2 2 2 DC-STAMP-like protein PAX PF00292.16 NM_011040.4_1 - 5.7e-72 239.4 0.4 8.6e-72 238.8 0.4 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 NM_011040.4_1 - 1.5e-54 182.8 16.7 3.3e-54 181.7 16.7 1.6 1 0 0 1 1 1 1 Paired-box protein 2 C terminal HTH_23 PF13384.4 NM_011040.4_1 - 0.00013 21.5 0.0 0.00024 20.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.4 NM_011040.4_1 - 0.072 13.1 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_32 PF13565.4 NM_011040.4_1 - 0.2 12.2 7.2 0.41 11.2 0.0 3.0 3 1 1 4 4 4 0 Homeodomain-like domain DUF4639 PF15479.4 NM_027948.1_2 - 2.1e-262 872.2 23.4 2.5e-262 871.9 23.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4639) Luteo_Vpg PF01659.14 NM_001270431.1_1 - 0.039 14.1 0.1 0.057 13.6 0.1 1.3 1 0 0 1 1 1 0 Luteovirus putative VPg genome linked protein Pkinase PF00069.23 NM_001201364.1_2 - 8.8e-70 234.9 0.0 1.2e-69 234.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001201364.1_2 - 8.2e-44 149.7 0.0 1.3e-43 149.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001201364.1_2 - 1.6e-06 27.5 0.1 5.4e-06 25.8 0.0 2.0 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.20 NM_001201364.1_2 - 0.00016 21.2 0.2 0.00031 20.3 0.2 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 NM_001201364.1_2 - 0.0012 18.1 0.2 0.0021 17.3 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.7 NM_001201364.1_2 - 0.012 15.0 0.2 0.044 13.2 0.1 1.7 1 1 1 2 2 2 0 PhoP regulatory network protein YrbL Dynein_heavy PF03028.13 NM_133365.3_1 - 5.3e-250 831.4 0.5 2.9e-249 828.9 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.10 NM_133365.3_1 - 1.2e-171 572.0 13.4 1.2e-171 572.0 13.4 3.5 4 0 0 4 4 4 2 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.11 NM_133365.3_1 - 2.3e-130 435.2 9.0 2.3e-130 435.2 9.0 3.6 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 NM_133365.3_1 - 6.8e-94 313.8 0.0 1.5e-93 312.6 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.5 NM_133365.3_1 - 1.2e-85 286.0 3.9 1.2e-85 286.0 3.9 3.5 4 0 0 4 4 3 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 NM_133365.3_1 - 1.5e-70 237.3 0.0 3.7e-70 236.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 NM_133365.3_1 - 3e-53 180.8 0.0 5.9e-53 179.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.5 NM_133365.3_1 - 5.9e-45 153.6 12.7 1.2e-44 152.7 12.7 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 NM_133365.3_1 - 1.1e-21 77.1 0.1 1.2e-07 31.7 0.0 6.1 6 1 0 6 6 6 4 AAA domain (dynein-related subfamily) AAA PF00004.27 NM_133365.3_1 - 4e-07 30.4 0.1 1.4 9.2 0.0 4.7 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 NM_133365.3_1 - 0.00015 22.1 2.9 6 7.1 0.0 5.6 5 1 0 5 5 4 1 AAA ATPase domain AAA_29 PF13555.4 NM_133365.3_1 - 0.00092 18.7 0.7 0.76 9.4 0.0 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_22 PF13401.4 NM_133365.3_1 - 0.0014 18.8 3.3 10 6.3 0.0 5.2 5 0 0 5 5 5 0 AAA domain AAA_18 PF13238.4 NM_133365.3_1 - 0.0057 17.0 0.1 3.1 8.2 0.0 4.0 3 0 0 3 3 3 1 AAA domain FtsK_SpoIIIE PF01580.16 NM_133365.3_1 - 0.021 14.0 0.2 0.13 11.4 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Roc PF08477.11 NM_133365.3_1 - 0.022 14.9 0.1 12 6.0 0.0 3.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.4 NM_133365.3_1 - 0.022 14.8 1.9 0.52 10.3 0.0 3.6 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.20 NM_133365.3_1 - 0.092 13.0 0.3 4.4 7.6 0.0 3.5 3 0 0 3 3 3 0 RNA helicase Mg_chelatase PF01078.19 NM_133365.3_1 - 0.34 10.1 1.7 14 4.9 0.2 3.7 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI DUF4407 PF14362.4 NM_133365.3_1 - 1.3 8.2 17.3 2.4 7.3 2.8 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) ABC_tran PF00005.25 NM_133365.3_1 - 2.1 8.7 11.8 4.7 7.6 0.0 4.9 6 0 0 6 6 3 0 ABC transporter IL7 PF01415.14 NM_008371.5_2 - 5.1e-45 152.7 8.2 7.8e-45 152.1 8.2 1.3 1 0 0 1 1 1 1 Interleukin 7/9 family RNase_PH PF01138.19 NM_027869.1_2 - 3.8e-39 134.1 0.1 7.5e-21 74.9 0.0 2.4 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 NM_027869.1_2 - 1.9e-16 59.7 0.8 3.2e-11 42.9 0.1 2.7 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 PNPase PF03726.12 NM_027869.1_2 - 1.1e-07 32.0 1.3 1.1e-07 32.0 1.3 1.9 2 0 0 2 2 2 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain KH_1 PF00013.27 NM_027869.1_2 - 1.8e-07 30.7 0.0 2.7e-06 27.0 0.0 2.4 2 0 0 2 2 2 1 KH domain S1 PF00575.21 NM_027869.1_2 - 2.6e-06 27.6 0.0 1.7e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 S1 RNA binding domain Innexin PF00876.16 NM_001002005.2_1 - 4.3e-14 52.5 0.5 7.3e-14 51.7 0.0 1.5 2 0 0 2 2 2 1 Innexin Ribophorin_II PF05817.12 NM_019642.4_1 - 1.9e-223 743.4 14.3 2.3e-223 743.2 14.3 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II PI3K_rbd PF00794.16 NM_019642.4_1 - 0.011 15.7 0.0 4.6 7.3 0.0 2.7 2 0 0 2 2 2 0 PI3-kinase family, ras-binding domain Thioredoxin PF00085.18 NM_029582.2_3 - 2.1e-21 75.7 0.0 1.3e-09 37.8 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.4 NM_029582.2_3 - 2.3e-07 30.8 0.0 0.0051 16.7 0.0 3.6 3 1 0 3 3 3 2 Thioredoxin-like domain ATG16 PF08614.9 NM_029582.2_3 - 0.00058 20.0 7.4 0.00058 20.0 7.4 1.6 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Thioredoxin_8 PF13905.4 NM_029582.2_3 - 0.0046 17.1 0.1 0.052 13.8 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.4 NM_029582.2_3 - 0.026 14.6 4.7 2.1 8.4 0.3 3.0 3 0 0 3 3 3 0 Thioredoxin-like DUF836 PF05768.12 NM_029582.2_3 - 0.053 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) COG6 PF06419.9 NM_029582.2_3 - 0.54 8.3 3.3 0.83 7.7 3.3 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Macoilin PF09726.7 NM_029582.2_3 - 2.2 6.6 4.6 3.2 6.1 4.6 1.1 1 0 0 1 1 1 0 Transmembrane protein Nup54 PF13874.4 NM_029582.2_3 - 5.3 7.0 11.7 9.8 6.1 11.7 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Spec3 PF15795.3 NM_001081227.2_2 - 1.1e-24 86.6 10.2 2.2e-24 85.7 10.2 1.5 1 0 0 1 1 1 1 Ectodermal ciliogenesis protein TPD52 PF04201.13 NM_025741.2_1 - 1.1e-60 203.8 0.2 1.5e-60 203.4 0.2 1.1 1 0 0 1 1 1 1 Tumour protein D52 family EGF PF00008.25 NM_008714.3_1 - 1.3e-194 629.5 603.8 1.5e-08 34.7 6.5 38.6 39 0 0 39 39 37 35 EGF-like domain hEGF PF12661.5 NM_008714.3_1 - 3.2e-119 385.9 491.9 1.3e-06 28.7 7.6 39.5 38 0 0 38 38 36 33 Human growth factor-like EGF EGF_CA PF07645.13 NM_008714.3_1 - 8.3e-51 169.8 576.7 4e-11 42.8 5.3 37.4 20 10 18 38 38 33 22 Calcium-binding EGF domain Ank_2 PF12796.5 NM_008714.3_1 - 1.4e-27 95.9 18.7 1.5e-11 44.5 1.7 4.2 1 1 3 5 5 5 4 Ankyrin repeats (3 copies) Notch PF00066.15 NM_008714.3_1 - 1e-25 89.8 56.7 2.3e-12 47.0 13.8 15.2 17 1 1 18 18 6 3 LNR domain DUF3454 PF11936.6 NM_008714.3_1 - 1e-25 89.8 23.3 3.7e-25 88.0 23.3 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3454) Ank PF00023.28 NM_008714.3_1 - 1.4e-25 88.5 6.7 0.0002 21.5 0.0 6.9 6 0 0 6 6 6 6 Ankyrin repeat NOD PF06816.11 NM_008714.3_1 - 3.1e-25 87.4 0.0 5e-25 86.7 0.0 1.3 1 0 0 1 1 1 1 NOTCH protein NODP PF07684.10 NM_008714.3_1 - 4.4e-23 81.0 0.1 4.4e-23 81.0 0.1 4.0 4 0 0 4 4 3 1 NOTCH protein EGF_2 PF07974.11 NM_008714.3_1 - 2.4e-22 78.8 676.7 0.00095 19.4 6.1 39.7 40 1 0 40 40 35 28 EGF-like domain Ank_5 PF13857.4 NM_008714.3_1 - 2.3e-20 72.2 11.5 3e-08 33.7 0.1 6.0 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_008714.3_1 - 1.4e-17 63.6 2.3 7.3e-06 26.3 0.0 4.8 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_008714.3_1 - 4.8e-17 60.2 3.0 0.0039 17.4 0.0 7.7 7 0 0 7 7 7 3 Ankyrin repeat LRR_8 PF13855.4 NM_001122594.2_2 - 2e-40 136.2 61.6 4e-09 36.0 2.7 9.1 8 1 1 9 9 9 6 Leucine rich repeat LRR_4 PF12799.5 NM_001122594.2_2 - 2.2e-25 88.1 69.6 7.3e-08 32.4 2.5 12.0 6 3 6 14 14 14 12 Leucine Rich repeats (2 copies) PP2C PF00481.19 NM_001122594.2_2 - 1.3e-24 87.1 0.0 1.9e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PH PF00169.27 NM_001122594.2_2 - 0.038 14.4 0.0 0.095 13.1 0.0 1.7 1 0 0 1 1 1 0 PH domain LRR_1 PF00560.31 NM_001122594.2_2 - 0.12 12.8 51.5 15 6.4 0.1 15.6 14 3 1 15 15 15 0 Leucine Rich Repeat LRR_6 PF13516.4 NM_001122594.2_2 - 2.2 8.4 59.5 0.31 11.1 0.7 14.5 16 0 0 16 16 16 0 Leucine Rich repeat Astacin PF01400.22 NM_008585.2_2 - 5.1e-66 221.8 0.0 7.4e-66 221.3 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) MAM PF00629.21 NM_008585.2_2 - 1.1e-38 132.4 0.0 2e-38 131.6 0.0 1.4 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu EGF PF00008.25 NM_008585.2_2 - 9.6e-09 35.3 5.0 2.3e-08 34.1 5.0 1.7 1 0 0 1 1 1 1 EGF-like domain EGF_CA PF07645.13 NM_008585.2_2 - 0.22 11.6 7.1 0.6 10.2 7.1 1.7 1 0 0 1 1 1 0 Calcium-binding EGF domain hEGF PF12661.5 NM_008585.2_2 - 0.67 10.6 4.6 2 9.1 4.6 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_3 PF12947.5 NM_008585.2_2 - 4.3 7.5 7.9 10 6.3 7.9 1.7 1 0 0 1 1 1 0 EGF domain EGF_2 PF07974.11 NM_008585.2_2 - 5.3 7.4 13.1 0.81 10.0 7.8 2.4 2 0 0 2 2 2 0 EGF-like domain Pkinase PF00069.23 NM_177589.3_1 - 6.4e-49 166.5 0.0 1.3e-48 165.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_177589.3_1 - 4.2e-24 85.1 0.0 6.7e-13 48.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase RICTOR_V PF14668.4 NM_177589.3_1 - 0.0014 18.6 2.9 27 4.9 0.1 5.0 4 1 1 5 5 5 0 Rapamycin-insensitive companion of mTOR, domain 5 HEAT PF02985.20 NM_177589.3_1 - 0.0038 17.2 6.7 5.7 7.3 0.0 6.1 6 0 0 6 6 6 1 HEAT repeat DUF3385 PF11865.6 NM_177589.3_1 - 0.0039 16.9 0.1 0.017 14.8 0.1 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3385) DUF3361 PF11841.6 NM_177589.3_1 - 0.013 15.3 11.5 0.27 11.0 0.3 5.3 5 0 0 5 5 5 0 Domain of unknown function (DUF3361) Arm PF00514.21 NM_177589.3_1 - 0.054 13.4 3.3 8 6.5 0.0 4.9 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat DUF3730 PF12530.6 NM_177589.3_1 - 2.6 7.4 9.3 0.13 11.7 0.5 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3730) V-set PF07686.15 NM_021610.1_1 - 4.9e-19 68.4 7.0 1.5e-18 66.8 0.5 3.2 2 1 1 3 3 3 1 Immunoglobulin V-set domain ig PF00047.23 NM_021610.1_1 - 5e-16 58.5 3.7 8.4e-09 35.4 0.2 3.3 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_021610.1_1 - 1.8e-14 53.9 6.6 4.5e-08 33.5 1.1 3.1 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_021610.1_1 - 1.8e-11 43.8 0.6 8.9e-05 22.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_021610.1_1 - 1.2e-10 41.5 5.8 6e-07 29.6 0.5 3.5 2 1 0 2 2 2 2 Immunoglobulin domain Shisa PF13908.4 NM_021610.1_1 - 4e-05 23.8 0.0 6.9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Ig_5 PF16681.3 NM_021610.1_1 - 0.00017 21.8 1.2 0.023 15.0 0.0 3.0 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain IncA PF04156.12 NM_021610.1_1 - 0.047 13.3 0.0 0.072 12.7 0.0 1.2 1 0 0 1 1 1 0 IncA protein Izumo-Ig PF16706.3 NM_021610.1_1 - 0.063 13.2 0.0 0.62 10.0 0.0 2.2 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Glyco_hydro_56 PF01630.16 NM_029848.1_2 - 2.3e-134 447.5 1.3 2.8e-134 447.2 1.3 1.1 1 0 0 1 1 1 1 Hyaluronidase EGF PF00008.25 NM_029848.1_2 - 0.012 15.7 3.0 2.1 8.6 0.1 2.6 2 0 0 2 2 2 0 EGF-like domain EGF_2 PF07974.11 NM_029848.1_2 - 1.9 8.8 10.0 1.4 9.3 1.3 2.5 2 0 0 2 2 2 0 EGF-like domain 7tm_4 PF13853.4 NM_146547.1_1 - 2.3e-47 161.9 23.7 3.1e-47 161.5 23.7 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146547.1_1 - 3.2e-22 78.9 30.3 8.9e-22 77.5 30.3 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) RRM_1 PF00076.20 NM_001284195.1_1 - 6.8e-19 67.3 0.0 1e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 NM_001284195.1_1 - 0.00011 21.9 0.0 0.00022 21.0 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif PID PF00640.21 NM_001253887.1_2 - 2e-47 160.6 0.0 4.9e-39 133.4 0.0 2.4 2 1 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.24 NM_001253887.1_2 - 6.4e-06 25.9 3.0 6.4e-06 25.9 3.0 2.0 2 0 0 2 2 2 1 WW domain PTB PF08416.11 NM_001253887.1_2 - 8.9e-06 25.8 0.0 0.00011 22.2 0.0 2.2 2 0 0 2 2 2 1 Phosphotyrosine-binding domain PID_2 PF14719.4 NM_001253887.1_2 - 0.014 15.2 0.0 5.5 6.7 0.0 2.2 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) Arf PF00025.19 NM_206935.1_1 - 2.7e-29 101.7 0.0 3.2e-29 101.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 NM_206935.1_1 - 4.5e-10 39.7 0.0 6.2e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 NM_206935.1_1 - 3e-08 33.2 0.0 3.5e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 NM_206935.1_1 - 1.4e-07 31.1 0.0 1.9e-07 30.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.10 NM_206935.1_1 - 0.00058 19.2 0.0 0.00093 18.5 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 NM_206935.1_1 - 0.0013 18.7 0.0 0.0021 18.0 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 NM_206935.1_1 - 0.0065 16.6 0.0 0.063 13.4 0.0 1.9 1 1 1 2 2 2 1 AAA domain G-alpha PF00503.18 NM_206935.1_1 - 0.034 13.2 0.0 0.85 8.6 0.0 2.0 1 1 1 2 2 2 0 G-protein alpha subunit AAA_18 PF13238.4 NM_206935.1_1 - 0.035 14.5 0.0 0.043 14.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.4 NM_206935.1_1 - 0.088 12.2 0.0 0.13 11.7 0.0 1.4 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.25 NM_206935.1_1 - 0.095 13.1 0.0 0.13 12.7 0.0 1.2 1 0 0 1 1 1 0 ABC transporter DLIC PF05783.9 NM_206935.1_1 - 0.11 11.2 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) DUF258 PF03193.14 NM_206935.1_1 - 0.15 11.8 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 PduV-EutP PF10662.7 NM_206935.1_1 - 0.17 11.5 0.0 1.1 8.9 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.4 NM_206935.1_1 - 0.17 12.1 0.1 0.3 11.3 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain Bowman-Birk_leg PF00228.18 NM_206935.1_3 - 0.3 11.3 6.7 1.6 9.0 0.8 2.5 2 0 0 2 2 2 0 Bowman-Birk serine protease inhibitor family Mito_carr PF00153.25 NM_178766.5_2 - 2.1e-61 203.8 0.4 2.8e-21 75.1 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein S-antigen PF05756.9 NM_178766.5_2 - 3.6 7.7 4.9 0.37 10.9 0.2 1.7 2 0 0 2 2 2 0 S-antigen protein Homeobox PF00046.27 NM_008178.2_3 - 1.1e-21 76.3 4.4 1.7e-21 75.6 4.4 1.3 1 0 0 1 1 1 1 Homeobox domain Terminase_5 PF06056.10 NM_008178.2_3 - 0.2 11.4 0.2 0.41 10.4 0.2 1.4 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Ada3 PF10198.7 NM_008178.2_3 - 0.22 11.5 0.0 0.34 10.9 0.0 1.2 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 Voltage_CLC PF00654.18 NM_001146307.1_1 - 8.3e-73 245.5 24.7 8.3e-73 245.5 24.7 1.7 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.26 NM_001146307.1_1 - 2.4e-10 40.6 0.0 9.9e-08 32.2 0.1 2.8 3 0 0 3 3 3 2 CBS domain RGS12_us1 PF16613.3 NM_173402.2_3 - 1.3e-57 193.1 14.1 1.3e-57 193.1 14.1 3.7 4 0 0 4 4 3 1 Unstructured region of RGS12 RGS12_usC PF16612.3 NM_173402.2_3 - 2.2e-45 154.4 13.2 2.2e-45 154.4 13.2 2.5 2 0 0 2 2 2 1 C-terminal unstructured region of RGS12 RGS12_us2 PF16611.3 NM_173402.2_3 - 6.5e-34 116.1 7.8 6.5e-34 116.1 7.8 2.1 2 0 0 2 2 1 1 Unstructured region between RBD and GoLoco RBD PF02196.13 NM_173402.2_3 - 7.9e-33 112.3 0.0 3.1e-20 71.9 0.0 2.5 2 0 0 2 2 2 2 Raf-like Ras-binding domain RGS PF00615.17 NM_173402.2_3 - 9.5e-27 93.5 3.5 1.6e-26 92.8 3.5 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain PDZ PF00595.22 NM_173402.2_3 - 5.2e-13 49.0 0.0 1.4e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) GoLoco PF02188.15 NM_173402.2_3 - 6.8e-09 34.9 0.3 1.5e-08 33.8 0.3 1.6 1 0 0 1 1 1 1 GoLoco motif PID PF00640.21 NM_173402.2_3 - 0.00091 19.1 0.0 0.002 18.0 0.0 1.6 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) DUF1388 PF07142.10 NM_173402.2_3 - 0.0014 18.4 1.4 0.003 17.4 1.4 1.6 1 0 0 1 1 1 1 Repeat of unknown function (DUF1388) PDZ_2 PF13180.4 NM_173402.2_3 - 0.003 17.7 0.0 0.0098 16.1 0.0 1.8 1 0 0 1 1 1 1 PDZ domain TUG-UBL1 PF11470.6 NM_173402.2_3 - 0.011 15.9 0.0 0.12 12.5 0.0 2.5 2 0 0 2 2 2 0 TUG ubiquitin-like domain zf-H2C2_2 PF13465.4 NM_023750.2_3 - 2.8e-78 255.0 98.1 5.9e-09 35.9 0.5 13.3 13 0 0 13 13 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_023750.2_3 - 5.6e-38 127.2 101.6 6.1e-05 23.1 2.7 12.4 12 0 0 12 12 12 10 Zinc finger, C2H2 type KRAB PF01352.25 NM_023750.2_3 - 1.5e-22 78.8 0.3 3e-22 77.9 0.3 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_023750.2_3 - 2.1e-19 68.4 97.8 0.04 14.6 1.8 12.9 12 0 0 12 12 12 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_023750.2_3 - 0.00017 21.5 66.3 0.046 13.7 2.8 7.8 4 2 5 9 9 9 8 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_023750.2_3 - 0.00026 20.7 70.6 1.2 9.0 0.1 12.0 12 0 0 12 12 12 8 C2H2-type zinc finger Homeobox PF00046.27 NM_001080549.2_3 - 5.2e-10 38.9 1.9 0.0004 20.0 0.0 2.6 2 0 0 2 2 2 2 Homeobox domain PPV_E1_N PF00524.16 NM_001080549.2_3 - 0.12 12.7 3.0 0.28 11.5 3.0 1.6 1 0 0 1 1 1 0 E1 Protein, N terminal domain Apyrase PF06079.9 NM_001267591.1_1 - 2.3e-131 437.2 0.1 2.8e-131 436.9 0.1 1.1 1 0 0 1 1 1 1 Apyrase SRCR PF00530.16 NM_001160366.1_1 - 6.6e-117 382.6 29.0 6.5e-30 103.5 1.5 4.3 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 NM_001160366.1_1 - 6.8e-14 52.0 16.7 0.003 17.9 0.7 4.7 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SCA7 PF08313.10 NM_139227.4_2 - 3e-26 91.0 2.2 3e-26 91.0 2.2 2.3 2 0 0 2 2 2 1 SCA7, zinc-binding domain zf-H2C2_2 PF13465.4 NM_009557.3_3 - 1.4e-84 274.9 88.4 7.4e-09 35.5 1.4 13.7 13 0 0 13 13 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_009557.3_3 - 1.2e-70 230.1 100.1 5.1e-07 29.7 1.9 13.3 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_009557.3_3 - 6.8e-38 125.9 94.0 0.0011 19.5 0.4 13.4 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_009557.3_3 - 5.5e-24 83.5 83.7 1.6e-05 24.6 0.3 12.7 12 0 0 12 12 12 12 C2H2-type zinc finger KRAB PF01352.25 NM_009557.3_3 - 6.2e-23 80.1 0.2 1.4e-22 79.0 0.2 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_009557.3_3 - 2.2e-13 50.0 59.6 0.011 15.9 0.1 12.4 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_009557.3_3 - 1.3e-09 37.9 57.6 0.0048 16.8 1.9 7.9 5 3 2 7 7 7 7 Zinc ribbon domain XPA_N PF01286.16 NM_009557.3_3 - 1.5e-05 24.8 45.2 3.6 7.6 0.3 11.9 12 0 0 12 12 12 3 XPA protein N-terminal zinc_ribbon_15 PF17032.3 NM_009557.3_3 - 0.00049 20.7 44.3 0.23 12.1 1.0 6.5 1 1 5 6 6 6 3 zinc-ribbon family HTH_18 PF12833.5 NM_009557.3_3 - 5.7 7.1 6.4 89 3.3 0.0 5.0 6 3 0 6 6 6 0 Helix-turn-helix domain COesterase PF00135.26 NM_001272045.1_1 - 1.7e-164 548.4 0.0 1.9e-164 548.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 NM_001272045.1_1 - 8.9e-10 38.6 0.3 4.3e-09 36.4 0.3 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_001272045.1_1 - 1.5e-06 27.8 0.0 2.2e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.7 NM_001272045.1_1 - 0.042 12.6 0.0 0.066 11.9 0.0 1.3 1 0 0 1 1 1 0 Steryl acetyl hydrolase DnaJ_C PF01556.16 NM_026400.5_3 - 2.5e-33 115.1 0.1 3.7e-33 114.6 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 NM_026400.5_3 - 4.1e-28 97.2 1.2 6.3e-28 96.6 1.2 1.3 1 0 0 1 1 1 1 DnaJ domain Pkinase PF00069.23 NM_152804.2_2 - 2.6e-70 236.7 0.0 3.7e-70 236.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_152804.2_2 - 1.5e-38 132.5 0.0 2.5e-38 131.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.16 NM_152804.2_2 - 8e-34 115.5 1.5 2.8e-16 59.3 0.0 2.6 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.4 NM_152804.2_2 - 0.00062 19.0 0.0 0.003 16.8 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Filament PF00038.19 NM_001159374.2_1 - 3.2e-104 348.7 32.1 3.7e-104 348.5 32.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 NM_001159374.2_1 - 0.00066 19.6 25.3 0.027 14.4 6.0 3.5 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein DUF2312 PF10073.7 NM_001159374.2_1 - 0.005 16.3 0.3 0.016 14.7 0.3 1.9 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2312) Lzipper-MIP1 PF14389.4 NM_001159374.2_1 - 0.019 15.1 0.8 0.019 15.1 0.8 4.3 3 2 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 DUF5082 PF16888.3 NM_001159374.2_1 - 0.084 13.1 15.0 0.13 12.5 0.3 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.10 NM_001159374.2_1 - 0.1 12.5 14.2 0.015 15.2 4.5 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Jnk-SapK_ap_N PF09744.7 NM_001159374.2_1 - 0.13 12.4 26.2 0.18 11.9 4.5 3.7 2 2 2 4 4 4 0 JNK_SAPK-associated protein-1 Cob_adeno_trans PF01923.16 NM_001159374.2_1 - 0.2 11.6 2.9 1.6 8.7 2.4 2.6 1 1 0 1 1 1 0 Cobalamin adenosyltransferase ERM PF00769.17 NM_001159374.2_1 - 0.53 9.9 16.9 0.064 12.9 11.6 1.9 1 1 1 2 2 2 0 Ezrin/radixin/moesin family TRAF_BIRC3_bd PF16673.3 NM_001159374.2_1 - 1.7 8.3 6.2 0.27 10.9 0.8 2.5 3 0 0 3 3 2 0 TNF receptor-associated factor BIRC3 binding domain NYD-SP28_assoc PF14775.4 NM_001159374.2_1 - 1.9 8.5 10.5 1.3 9.1 0.7 4.1 3 1 1 4 4 4 0 Sperm tail C-terminal domain DUF3251 PF11622.6 NM_001159374.2_1 - 2 7.9 4.6 0.5 9.9 0.5 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3251) DUF1664 PF07889.10 NM_001159374.2_1 - 2.1 8.2 18.7 1.9 8.3 1.4 4.3 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) SKA1 PF07160.10 NM_001159374.2_1 - 2.7 7.6 13.4 0.04 13.6 4.0 2.4 1 1 1 3 3 3 0 Spindle and kinetochore-associated protein 1 Bacillus_HBL PF05791.9 NM_001159374.2_1 - 3.7 7.1 14.6 0.042 13.4 2.8 3.1 3 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DUF4600 PF15372.4 NM_001159374.2_1 - 4.9 7.5 19.9 15 5.9 0.2 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4600) Fib_alpha PF08702.8 NM_001159374.2_1 - 5.8 7.0 18.0 3.2 7.8 7.0 3.3 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family IncA PF04156.12 NM_001159374.2_1 - 6.2 6.4 30.5 1.6e+04 -10.5 30.5 3.2 1 1 0 1 1 0 0 IncA protein Spore_GerAC PF05504.9 NM_001159374.2_1 - 7.2 6.8 9.1 29 4.8 6.4 2.9 1 1 0 2 2 2 0 Spore germination B3/ GerAC like, C-terminal DivIC PF04977.13 NM_001159374.2_1 - 8.2 6.1 22.7 13 5.5 1.0 5.0 5 0 0 5 5 5 0 Septum formation initiator MFS_1 PF07690.14 NM_183116.2_3 - 9.1e-47 159.5 46.3 1.4e-24 86.5 18.4 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily LEM PF03020.13 NM_001253814.1_3 - 5.8e-09 35.2 0.0 1.8e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 LEM domain Ank_5 PF13857.4 NM_001253814.1_3 - 8.1e-08 32.3 0.0 0.025 14.8 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_001253814.1_3 - 5.6e-05 23.5 0.0 0.0014 19.0 0.0 2.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001253814.1_3 - 0.00048 20.5 0.0 0.002 18.5 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Cauli_VI PF01693.14 NM_001253814.1_3 - 0.0066 16.6 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin Ank_3 PF13606.4 NM_001253814.1_3 - 0.017 15.5 0.1 0.15 12.6 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat Ank PF00023.28 NM_001253814.1_3 - 0.1 12.9 0.1 0.49 10.8 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeat Homeobox PF00046.27 NM_178245.3_1 - 7.5e-22 76.8 1.8 1.1e-21 76.2 1.8 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_178245.3_1 - 0.027 14.2 0.0 0.081 12.7 0.0 1.8 1 0 0 1 1 1 0 Homeobox KN domain FAT PF02259.21 NM_020009.2_1 - 2.5e-131 437.9 13.5 2.5e-131 437.9 13.5 2.3 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.25 NM_020009.2_1 - 9.1e-77 258.1 0.1 1.7e-76 257.2 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.6 NM_020009.2_1 - 1.4e-59 200.5 6.7 5.8e-58 195.2 0.1 4.8 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) FRB_dom PF08771.9 NM_020009.2_1 - 2.6e-46 155.9 0.4 2.6e-46 155.9 0.4 3.9 5 0 0 5 5 3 1 FKBP12-rapamycin binding domain FATC PF02260.18 NM_020009.2_1 - 4.9e-17 61.3 0.5 1.3e-16 60.0 0.5 1.8 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.4 NM_020009.2_1 - 3.9e-09 36.6 10.4 0.2 11.9 0.0 8.2 10 0 0 10 10 9 3 HEAT repeats HEAT PF02985.20 NM_020009.2_1 - 1.7e-05 24.5 16.1 10 6.6 0.1 12.5 15 0 0 15 15 14 1 HEAT repeat V-ATPase_H_N PF03224.12 NM_020009.2_1 - 0.0014 17.9 0.2 0.97 8.5 0.1 3.4 3 0 0 3 3 3 2 V-ATPase subunit H HEAT_EZ PF13513.4 NM_020009.2_1 - 0.0026 18.0 27.8 0.1 12.9 0.0 12.4 15 0 0 15 15 15 1 HEAT-like repeat UME PF08064.11 NM_020009.2_1 - 0.0056 16.5 7.9 0.42 10.4 0.4 5.4 5 1 0 5 5 5 1 UME (NUC010) domain EPSP_synthase PF00275.18 NM_020009.2_1 - 0.029 12.9 0.0 0.053 12.1 0.0 1.3 1 0 0 1 1 1 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) TPR_19 PF14559.4 NM_020009.2_1 - 0.039 14.3 0.1 6.6 7.2 0.0 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat ParcG PF10274.7 NM_020009.2_1 - 1.3 8.9 5.1 19 5.2 0.2 4.3 3 1 1 4 4 3 0 Parkin co-regulated protein MH2 PF03166.12 NM_001164041.1_1 - 9.2e-75 250.8 1.6 1.3e-74 250.3 1.6 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 NM_001164041.1_1 - 2.6e-41 139.9 0.3 4.8e-41 139.0 0.3 1.5 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 NM_001164041.1_1 - 0.0036 17.0 0.0 0.0063 16.2 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 HLH PF00010.24 NM_001164151.1_2 - 3.7e-10 39.5 0.8 7.6e-10 38.5 0.8 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Sulfotransfer_1 PF00685.25 NM_013873.3_3 - 2e-57 194.6 0.0 3e-57 194.0 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_013873.3_3 - 4.7e-09 36.8 0.1 2.8e-07 31.0 0.2 2.2 2 0 0 2 2 2 1 Sulfotransferase family FdsD PF11390.6 NM_013873.3_3 - 0.011 16.0 0.1 3.6 7.8 0.1 2.4 2 0 0 2 2 2 0 NADH-dependant formate dehydrogenase delta subunit FdsD TPR_1 PF00515.26 NM_016737.2_1 - 2e-55 182.3 45.0 8.7e-08 31.5 0.3 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.15 NM_016737.2_1 - 4.2e-45 148.1 36.5 2.2e-06 27.2 0.4 9.6 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.4 NM_016737.2_1 - 3.3e-28 97.0 23.5 1.4e-08 34.2 0.1 7.2 5 2 2 7 7 7 5 TPR repeat TPR_8 PF13181.4 NM_016737.2_1 - 9.2e-25 84.6 36.0 0.0012 18.7 0.4 9.8 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.4 NM_016737.2_1 - 3.4e-22 78.4 22.4 1.6e-10 41.0 0.1 8.0 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.4 NM_016737.2_1 - 1.1e-17 63.1 6.1 0.14 12.9 0.0 8.3 4 3 4 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.4 NM_016737.2_1 - 1.3e-17 64.1 10.9 0.00078 19.9 0.0 6.5 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.4 NM_016737.2_1 - 3.7e-14 51.9 16.3 0.00017 21.6 0.5 7.5 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_016737.2_1 - 1.1e-13 51.4 20.6 0.012 16.0 0.1 6.7 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_9 PF13371.4 NM_016737.2_1 - 8.4e-13 48.2 0.5 0.007 16.4 0.0 4.9 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.4 NM_016737.2_1 - 1.9e-12 46.1 22.5 0.025 14.5 0.0 9.5 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_10 PF13374.4 NM_016737.2_1 - 1.9e-07 30.6 18.6 1 9.2 0.0 8.8 9 0 0 9 9 9 2 Tetratricopeptide repeat NARP1 PF12569.6 NM_016737.2_1 - 8.6e-07 28.1 24.1 0.0014 17.4 0.1 4.9 2 2 3 5 5 5 4 NMDA receptor-regulated protein 1 TPR_6 PF13174.4 NM_016737.2_1 - 2.4e-05 24.6 23.4 3 8.5 0.0 8.7 9 0 0 9 9 8 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_016737.2_1 - 0.0006 19.8 25.2 0.073 13.2 0.3 5.2 3 3 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.4 NM_016737.2_1 - 0.00081 19.3 24.8 1.1 9.3 0.4 7.7 7 1 1 8 8 7 2 Fis1 C-terminal tetratricopeptide repeat DnaI_N PF07319.9 NM_016737.2_1 - 0.0026 18.2 1.1 1.7 9.3 0.2 3.5 1 1 2 3 3 3 1 Primosomal protein DnaI N-terminus TPR_3 PF07720.10 NM_016737.2_1 - 0.0048 16.7 27.6 0.57 10.1 0.1 7.5 7 0 0 7 7 7 1 Tetratricopeptide repeat DREPP PF05558.10 NM_016737.2_1 - 0.11 12.3 5.2 1.8 8.2 0.1 3.2 3 0 0 3 3 3 0 DREPP plasma membrane polypeptide MIT PF04212.16 NM_016737.2_1 - 0.19 11.7 38.0 0.41 10.6 1.1 8.1 7 1 1 8 8 8 0 MIT (microtubule interacting and transport) domain DUF5113 PF17140.2 NM_016737.2_1 - 0.25 11.0 11.7 2.1 8.0 0.2 4.7 4 1 0 4 4 4 0 Domain of unknown function (DUF5113) Wtap PF17098.3 NM_016737.2_1 - 0.26 11.1 6.2 0.34 10.7 0.1 3.0 3 0 0 3 3 3 0 WTAP/Mum2p family Alkyl_sulf_dimr PF14863.4 NM_016737.2_1 - 0.28 11.5 5.3 1.5 9.1 0.1 3.7 3 1 0 3 3 3 0 Alkyl sulfatase dimerisation TPR_20 PF14561.4 NM_016737.2_1 - 0.3 11.3 10.7 0.58 10.4 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat MAS20 PF02064.13 NM_016737.2_1 - 0.65 10.0 7.2 9.6 6.2 0.3 4.2 3 1 2 5 5 4 0 MAS20 protein import receptor TOM20_plant PF06552.10 NM_016737.2_1 - 0.75 9.4 4.8 6.6 6.3 0.2 3.6 3 1 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 Sel1 PF08238.10 NM_016737.2_1 - 1 10.0 6.0 40 4.9 0.2 5.1 6 0 0 6 6 4 0 Sel1 repeat DUF3391 PF11871.6 NM_016737.2_1 - 2.5 8.5 5.4 1.3 9.4 0.7 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF3391) MOZART1 PF12554.6 NM_175245.4_2 - 4.8e-24 83.7 1.3 7.9e-24 83.0 1.3 1.4 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated zf-HC5HC2H_2 PF13832.4 NM_001282127.1_2 - 3.2e-37 126.9 7.4 3.2e-37 126.9 7.4 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.7 NM_001282127.1_2 - 1.7e-35 122.6 7.9 1.7e-35 122.6 7.9 3.1 3 0 0 3 3 3 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.4 NM_001282127.1_2 - 4.9e-26 90.6 6.1 4.9e-26 90.6 6.1 3.9 4 0 0 4 4 4 1 PHD-like zinc-binding domain Bromodomain PF00439.23 NM_001282127.1_2 - 1.2e-22 79.7 0.6 2.6e-22 78.5 0.6 1.6 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.15 NM_001282127.1_2 - 1.2e-14 54.4 1.2 2.7e-14 53.2 0.0 2.4 2 0 0 2 2 2 1 PWWP domain PHD_2 PF13831.4 NM_001282127.1_2 - 1.4e-14 53.1 3.3 1.4e-14 53.1 3.3 3.0 3 1 0 3 3 3 1 PHD-finger PHD PF00628.27 NM_001282127.1_2 - 5.4e-07 29.3 12.6 5.4e-07 29.3 12.6 3.6 3 0 0 3 3 3 2 PHD-finger PGA2 PF07543.10 NM_001282127.1_2 - 0.57 10.0 8.2 0.8 9.6 1.2 3.3 2 0 0 2 2 2 0 Protein trafficking PGA2 UDPGT PF00201.16 NM_145079.3_3 - 1.3e-229 762.9 0.0 1.6e-229 762.7 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 NM_145079.3_3 - 8.9e-07 28.9 0.0 1.5e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain PH PF00169.27 NM_001177796.1_2 - 1.3e-19 70.5 1.0 1.5e-08 35.0 0.0 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.4 NM_001177796.1_2 - 1.5e-05 25.2 4.2 0.024 14.9 0.1 3.1 3 1 0 3 3 3 2 Pleckstrin homology domain Mod_r PF07200.11 NM_001177796.1_2 - 0.0089 16.0 5.2 0.024 14.6 5.2 1.6 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein CENP-Q PF13094.4 NM_001177796.1_2 - 0.02 14.9 5.6 0.049 13.7 5.6 1.7 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit APG6 PF04111.10 NM_001177796.1_2 - 1.5 8.0 4.6 2.8 7.1 4.6 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.9 NM_001177796.1_2 - 1.6 7.4 8.1 2.7 6.7 8.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein tRNA-synt_2b PF00587.23 NM_001163617.1_2 - 9.3e-30 103.8 0.0 1.8e-29 102.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.18 NM_001163617.1_2 - 8.3e-18 64.2 0.4 1.5e-17 63.4 0.4 1.4 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.19 NM_001163617.1_2 - 1.4e-12 47.3 0.0 2.5e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.12 NM_001163617.1_2 - 1.3e-10 41.1 0.0 3.5e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain SNF2_N PF00176.21 NM_001081345.2_3 - 6.1e-67 225.7 0.4 9.8e-67 225.0 0.4 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.22 NM_001081345.2_3 - 4.6e-34 116.0 12.9 5e-23 80.6 0.0 4.2 3 1 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.4 NM_001081345.2_3 - 7.8e-26 90.2 1.1 4e-25 88.0 1.1 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) Helicase_C PF00271.29 NM_001081345.2_3 - 1.3e-19 70.5 0.0 2.9e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_001081345.2_3 - 1.6e-09 37.8 0.9 6.5e-08 32.6 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.9 NM_001081345.2_3 - 0.0072 16.4 0.0 0.093 12.8 0.0 2.5 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain Myb_DNA-binding PF00249.29 NM_001081345.2_3 - 0.051 13.6 0.1 0.85 9.7 0.1 2.6 2 0 0 2 2 2 0 Myb-like DNA-binding domain C2 PF00168.28 NM_001029873.2_3 - 1.5e-53 179.3 9.5 3.7e-26 91.3 0.3 4.0 4 0 0 4 4 4 3 C2 domain Membr_traf_MHD PF10540.7 NM_001029873.2_3 - 1.9e-51 174.1 1.8 4.3e-51 172.9 1.8 1.7 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain DUF1041 PF06292.15 NM_001029873.2_3 - 1.8e-35 121.3 0.1 1.8e-35 121.3 0.1 2.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1041) C1_1 PF00130.20 NM_001029873.2_3 - 5.2e-11 42.1 6.2 1.3e-10 40.8 6.2 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Sulfotransfer_1 PF00685.25 NM_010474.2_1 - 1e-38 133.2 0.0 1.4e-38 132.8 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_010474.2_1 - 1.2e-14 55.1 0.1 1.5e-09 38.4 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.12 NM_010474.2_1 - 0.0019 18.1 0.1 0.0072 16.1 0.0 1.8 2 0 0 2 2 2 1 Sulfotransferase family Cpn60_TCP1 PF00118.22 NM_001008502.2_1 - 7.6e-20 70.9 0.1 1e-10 40.8 0.0 2.5 3 0 0 3 3 3 2 TCP-1/cpn60 chaperonin family GFO_IDH_MocA PF01408.20 NM_027903.3_1 - 1.3e-22 80.7 1.0 1.9e-22 80.2 0.2 1.7 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.14 NM_027903.3_1 - 0.029 14.9 0.1 0.054 14.0 0.1 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.15 NM_027903.3_1 - 0.076 13.5 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.18 NM_027903.3_1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF4615 PF15393.4 NM_054099.2_2 - 1.7e-37 128.5 0.2 3.1e-37 127.7 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4615) Pou PF00157.15 NM_010127.3_1 - 4.8e-29 100.1 0.1 8.3e-29 99.3 0.1 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 NM_010127.3_1 - 2.3e-18 65.6 0.8 4.5e-18 64.7 0.8 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_010127.3_1 - 0.0062 16.3 0.1 0.021 14.6 0.0 1.8 2 0 0 2 2 2 1 Homeobox KN domain Serpin PF00079.18 NM_001199940.1_3 - 1.1e-116 390.0 0.8 1.3e-116 389.8 0.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Mei4 PF13971.4 NM_175213.3_3 - 1.5e-88 297.4 4.2 2.2e-88 296.9 4.2 1.2 1 0 0 1 1 1 1 Meiosis-specific protein Mei4 Bcl-2 PF00452.17 NM_007536.2_3 - 1.2e-24 86.6 0.1 1.9e-24 86.0 0.1 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family KH_1 PF00013.27 NM_011865.3_2 - 3.7e-51 170.7 14.5 1.3e-17 63.3 0.9 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 NM_011865.3_2 - 2.6e-15 55.9 4.9 0.0005 19.7 0.6 3.2 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 NM_011865.3_2 - 2.9e-07 30.2 2.9 0.057 13.2 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.4 NM_011865.3_2 - 0.00053 19.9 8.8 1.2 9.1 0.2 3.3 3 0 0 3 3 3 3 NusA-like KH domain Bac_chlorC PF02043.15 NM_011865.3_2 - 0.054 13.4 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 Bacteriochlorophyll C binding protein Abhydrolase_1 PF00561.18 NM_026334.3_3 - 3.9e-25 88.8 0.0 1.4e-24 87.0 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.14 NM_026334.3_3 - 1.3e-24 85.4 0.0 2.5e-24 84.5 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.6 NM_026334.3_3 - 4.2e-06 26.1 0.0 0.00042 19.5 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Esterase PF00756.18 NM_026334.3_3 - 0.023 14.2 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Hexapep PF00132.22 NM_001293757.1_1 - 1.2e-06 27.9 4.1 7.9e-05 22.1 0.7 3.1 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) amfpi-1 PF12190.6 NM_001293757.1_1 - 0.029 14.9 1.3 0.071 13.6 1.3 1.6 1 0 0 1 1 1 0 Fungal protease inhibitor KBP_C PF12309.6 NM_028197.2_3 - 9.4e-120 400.2 3.6 9.4e-120 400.2 3.6 2.5 2 1 0 2 2 2 1 KIF-1 binding protein C terminal TPR_12 PF13424.4 NM_028197.2_3 - 0.056 13.6 6.2 4.7 7.5 0.9 3.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.4 NM_028197.2_3 - 0.067 13.1 3.9 3.7 7.7 0.3 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 NM_028197.2_3 - 0.073 12.8 7.8 0.09 12.5 0.6 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_028197.2_3 - 2.4 8.4 10.8 0.91 9.7 0.6 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat PNMA PF14893.4 NM_153169.2_3 - 2.1e-135 451.3 1.2 2.6e-135 450.9 1.2 1.1 1 0 0 1 1 1 1 PNMA zf-CCHC PF00098.21 NM_153169.2_3 - 0.12 12.4 3.8 0.34 10.9 3.8 1.9 1 0 0 1 1 1 0 Zinc knuckle LRR_8 PF13855.4 NM_001285956.1_2 - 1.6e-74 245.4 49.5 1.7e-16 59.6 4.2 9.1 7 3 1 9 9 9 9 Leucine rich repeat LRR_4 PF12799.5 NM_001285956.1_2 - 4.8e-43 144.1 46.9 4.8e-06 26.7 1.2 11.8 5 2 10 15 15 15 15 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001285956.1_2 - 1e-19 67.7 42.2 0.84 10.2 0.2 15.8 14 2 2 16 16 16 6 Leucine Rich Repeat LRR_9 PF14580.4 NM_001285956.1_2 - 2.7e-12 46.4 17.2 0.013 14.9 0.8 6.5 1 1 5 7 7 7 6 Leucine-rich repeat LRR_5 PF13306.4 NM_001285956.1_2 - 5.8e-12 45.6 0.0 0.054 13.3 0.0 4.7 3 1 1 4 4 4 4 Leucine rich repeats (6 copies) LRR_6 PF13516.4 NM_001285956.1_2 - 4.7e-09 35.4 35.9 1.3 9.1 0.3 14.0 15 0 0 15 15 15 5 Leucine Rich repeat FNIP PF05725.10 NM_001285956.1_2 - 0.00027 20.9 8.5 8.4 6.5 0.1 6.3 4 2 1 5 5 5 2 FNIP Repeat LRRNT PF01462.16 NM_001285956.1_2 - 0.002 17.6 2.0 0.002 17.6 2.0 4.7 6 0 0 6 6 6 1 Leucine rich repeat N-terminal domain PAXX PF15384.4 NM_153557.1_1 - 1.2e-88 295.7 0.0 1.5e-88 295.4 0.0 1.1 1 0 0 1 1 1 1 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 MAPEG PF01124.16 NM_025569.1_1 - 2.4e-24 85.5 0.8 3.3e-24 85.1 0.8 1.2 1 0 0 1 1 1 1 MAPEG family AlbA_2 PF04326.12 NM_011407.1_3 - 4.2e-16 59.2 1.7 1.6e-13 51.0 0.2 2.6 3 0 0 3 3 3 2 Putative DNA-binding domain B3R PF17057.3 NM_011407.1_3 - 1.5e-06 28.2 0.0 3.5e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Poxviridae B3 protein CTP_transf_like PF01467.24 NM_009981.4_2 - 6e-31 107.4 0.0 1.1e-30 106.6 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like DUF1664 PF07889.10 NM_009981.4_2 - 0.19 11.6 1.2 0.33 10.8 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) YtxH PF12732.5 NM_009981.4_2 - 1.3 9.4 3.4 2.5 8.6 3.4 1.3 1 0 0 1 1 1 0 YtxH-like protein HLH PF00010.24 NM_001253865.1_1 - 1.8e-10 40.5 1.2 8.8e-10 38.3 1.3 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Ras PF00071.20 NM_001278447.1_3 - 1.1e-52 177.8 0.1 1.5e-52 177.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001278447.1_3 - 2.4e-33 114.8 0.0 3.5e-33 114.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001278447.1_3 - 2e-13 50.1 0.1 2.9e-13 49.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001278447.1_3 - 5.6e-05 23.1 0.0 0.00014 21.8 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 NM_001278447.1_3 - 0.0054 16.1 0.1 0.013 15.0 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 NM_001278447.1_3 - 0.012 15.4 0.1 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 NM_001278447.1_3 - 0.019 14.2 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_24 PF13479.4 NM_001278447.1_3 - 0.046 13.3 0.0 0.066 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 NM_001278447.1_3 - 0.054 13.7 0.0 0.09 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 NM_001278447.1_3 - 0.11 12.7 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 NM_001278447.1_3 - 0.14 11.7 0.1 0.27 10.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain PRP1_N PF06424.10 NM_133701.2_2 - 1.6e-59 200.2 6.2 3.7e-59 199.0 6.2 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.4 NM_133701.2_2 - 4e-30 101.8 25.2 0.0017 18.9 0.1 13.6 6 3 9 15 15 14 8 Tetratricopeptide repeat TPR_19 PF14559.4 NM_133701.2_2 - 9.3e-23 80.4 7.9 5.9e-07 29.8 0.3 9.0 6 2 3 10 10 10 5 Tetratricopeptide repeat TPR_17 PF13431.4 NM_133701.2_2 - 3.9e-11 42.4 0.2 0.13 12.5 0.0 8.1 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_133701.2_2 - 3.7e-08 32.8 10.8 0.79 9.9 0.0 9.8 11 1 1 12 12 11 1 Tetratricopeptide repeat TPR_16 PF13432.4 NM_133701.2_2 - 2.3e-07 31.3 15.0 0.012 16.2 0.0 7.9 8 1 0 8 8 7 1 Tetratricopeptide repeat Suf PF05843.12 NM_133701.2_2 - 1.4e-06 28.3 0.4 0.11 12.3 0.0 5.3 6 0 0 6 6 6 1 Suppressor of forked protein (Suf) TPR_8 PF13181.4 NM_133701.2_2 - 1.5e-06 27.8 0.0 1.3 9.3 0.0 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat FAT PF02259.21 NM_133701.2_2 - 0.00029 20.0 14.1 0.055 12.5 6.4 4.4 1 1 1 3 3 3 1 FAT domain TPR_1 PF00515.26 NM_133701.2_2 - 0.00031 20.3 0.1 1.6 8.5 0.0 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.4 NM_133701.2_2 - 0.001 19.1 3.3 25 5.0 0.0 5.6 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_133701.2_2 - 0.0015 18.9 4.8 97 3.8 0.0 8.2 11 0 0 11 11 8 0 Tetratricopeptide repeat AD PF09793.7 NM_133701.2_2 - 4 7.5 7.0 2.6 8.1 0.1 2.7 2 1 0 2 2 2 0 Anticodon-binding domain Cyclin_N PF00134.21 NM_001290422.1_1 - 1.3e-12 47.5 3.4 8.3e-12 44.9 0.8 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.3 NM_001290422.1_1 - 4.4e-06 26.9 0.1 9.3e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.17 NM_001290422.1_1 - 0.16 11.9 0.1 0.72 9.8 0.0 1.9 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Macscav_rec PF03523.11 NM_031195.2_2 - 5.1e-25 87.0 4.3 1.2e-24 85.8 4.3 1.7 1 0 0 1 1 1 1 Macrophage scavenger receptor Collagen PF01391.16 NM_031195.2_2 - 6.9e-13 48.0 66.3 4.2e-08 32.7 26.1 2.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) EI24 PF07264.9 NM_031195.2_2 - 0.039 14.1 1.4 4.4 7.4 0.0 2.6 3 0 0 3 3 3 0 Etoposide-induced protein 2.4 (EI24) Reo_sigmaC PF04582.10 NM_031195.2_2 - 0.041 13.1 8.6 0.065 12.5 8.6 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF16 PF01519.14 NM_031195.2_2 - 0.8 10.1 14.0 8.9 6.7 10.5 3.1 2 1 0 2 2 2 0 Protein of unknown function DUF16 SKA2 PF16740.3 NM_031195.2_2 - 1.6 8.4 11.6 8.3 6.1 0.5 2.7 1 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 MCPsignal PF00015.19 NM_031195.2_2 - 6.5 6.3 11.1 1.9 8.1 3.9 2.1 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Dynein_heavy PF03028.13 NM_010060.3_2 - 6.1e-235 781.6 0.0 1.3e-234 780.5 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.10 NM_010060.3_2 - 2.7e-161 537.9 4.4 2.7e-161 537.9 4.4 2.6 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 MT PF12777.5 NM_010060.3_2 - 9.4e-160 531.1 8.7 1.7e-159 530.3 8.7 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_6 PF12774.5 NM_010060.3_2 - 8.6e-142 470.5 0.0 2.4e-141 469.1 0.0 1.8 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.5 NM_010060.3_2 - 1.9e-135 450.1 0.0 3.9e-135 449.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 NM_010060.3_2 - 1.3e-132 441.0 0.5 1e-130 434.8 0.2 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 DHC_N2 PF08393.11 NM_010060.3_2 - 7.9e-122 407.1 15.4 7.9e-122 407.1 15.4 3.3 2 1 1 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.5 NM_010060.3_2 - 2e-84 282.0 0.6 2e-84 282.0 0.6 2.9 3 1 1 4 4 4 1 ATP-binding dynein motor region D5 AAA_5 PF07728.12 NM_010060.3_2 - 4.8e-26 91.3 0.0 4.5e-11 42.8 0.0 5.4 4 0 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 NM_010060.3_2 - 5.5e-08 33.2 1.7 0.11 12.7 0.0 6.0 5 1 1 6 6 5 2 AAA ATPase domain AAA_22 PF13401.4 NM_010060.3_2 - 2.7e-07 30.8 0.0 0.81 9.8 0.0 5.3 4 0 0 4 4 4 2 AAA domain AAA PF00004.27 NM_010060.3_2 - 3.9e-05 24.0 0.1 1.7 8.9 0.0 5.1 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.4 NM_010060.3_2 - 5.6e-05 23.4 0.7 1.8 8.7 0.0 4.1 3 0 0 3 3 3 2 AAA domain Laminin_II PF06009.10 NM_010060.3_2 - 0.00024 21.0 2.0 0.00024 21.0 2.0 3.5 4 0 0 4 4 1 1 Laminin Domain II AAA_30 PF13604.4 NM_010060.3_2 - 0.00032 20.4 0.6 0.49 10.0 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.4 NM_010060.3_2 - 0.00075 19.9 0.2 2.4 8.5 0.0 4.5 4 0 0 4 4 4 1 AAA domain NACHT PF05729.10 NM_010060.3_2 - 0.00095 19.0 1.7 0.28 10.9 0.0 4.7 6 0 0 6 6 4 1 NACHT domain RNA_helicase PF00910.20 NM_010060.3_2 - 0.0039 17.4 0.4 32 4.9 0.0 4.6 5 0 0 5 5 4 0 RNA helicase Sigma54_activat PF00158.24 NM_010060.3_2 - 0.0079 15.8 0.0 1.3 8.6 0.0 3.2 3 0 0 3 3 3 1 Sigma-54 interaction domain DUF2075 PF09848.7 NM_010060.3_2 - 0.012 14.8 0.0 3.1 6.8 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Roc PF08477.11 NM_010060.3_2 - 0.02 15.0 0.0 8.4 6.5 0.0 3.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.15 NM_010060.3_2 - 0.021 14.7 0.4 4.3 7.2 0.0 3.5 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.4 NM_010060.3_2 - 0.036 13.6 0.2 36 3.9 0.0 3.6 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.25 NM_010060.3_2 - 0.043 14.2 0.0 11 6.4 0.0 3.8 3 0 0 3 3 2 0 ABC transporter Pox_A32 PF04665.10 NM_010060.3_2 - 0.096 12.0 0.1 1.8 7.8 0.1 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_25 PF13481.4 NM_010060.3_2 - 0.11 11.9 0.6 0.65 9.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain Mg_chelatase PF01078.19 NM_010060.3_2 - 0.23 10.7 2.0 6.5 5.9 0.0 3.8 5 0 0 5 5 5 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.4 NM_010060.3_2 - 0.27 11.2 1.6 44 4.1 0.0 3.9 4 0 0 4 4 3 0 AAA domain Reo_sigmaC PF04582.10 NM_010060.3_2 - 3.1 7.0 6.0 3.2 6.9 0.1 2.8 3 0 0 3 3 2 0 Reovirus sigma C capsid protein 7tm_4 PF13853.4 NM_207572.1_1 - 1.2e-45 156.3 13.2 1.9e-45 155.7 13.2 1.2 1 1 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_207572.1_1 - 7.3e-20 71.2 14.3 3.7e-19 68.9 14.3 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_207572.1_1 - 6.3e-05 22.3 15.0 0.0078 15.5 15.0 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx MNE1 PF13762.4 NM_207572.1_1 - 0.03 14.2 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial splicing apparatus component Glycos_transf_2 PF00535.24 NM_001161767.1_2 - 2.3e-33 115.2 0.0 3.5e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 NM_001161767.1_2 - 6.2e-24 84.5 0.4 1.2e-23 83.6 0.4 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 NM_001161767.1_2 - 2.4e-08 33.4 0.0 6.3e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 NM_001161767.1_2 - 0.011 15.1 0.0 0.033 13.5 0.0 1.6 2 0 0 2 2 2 0 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.4 NM_001161767.1_2 - 0.048 14.3 0.0 9.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like MOZ_SAS PF01853.16 NM_001195003.1_3 - 2.5e-85 284.5 1.4 3.7e-85 283.9 1.4 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-C2HC PF01530.16 NM_001195003.1_3 - 2.5e-13 49.8 5.9 2.5e-13 49.8 5.9 2.6 2 0 0 2 2 2 1 Zinc finger, C2HC type Acetyltransf_7 PF13508.5 NM_001195003.1_3 - 0.13 12.6 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Mem_trans PF03547.16 NM_001190297.2_1 - 1.3e-17 63.1 17.7 3.2e-12 45.4 4.9 2.4 1 1 1 2 2 2 2 Membrane transport protein DEP PF00610.19 NM_001190297.2_1 - 4.1e-13 49.1 0.5 8.3e-13 48.1 0.0 1.8 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PP1c_bdg PF10488.7 NM_008654.2_2 - 1.2e-11 44.5 0.1 1.2e-11 44.5 0.1 3.4 3 1 0 4 4 4 1 Phosphatase-1 catalytic subunit binding region Asp_protease PF09668.8 NM_001017966.2_1 - 3.3e-61 204.4 0.6 4.9e-61 203.9 0.6 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.4 NM_001017966.2_1 - 6.7e-25 87.3 0.0 1.3e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.4 NM_001017966.2_1 - 2.5e-09 37.5 0.0 4.7e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease ubiquitin PF00240.21 NM_001017966.2_1 - 1.6e-06 27.6 0.0 3.2e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family RVP PF00077.18 NM_001017966.2_1 - 6.1e-05 23.1 0.0 0.00014 22.0 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.9 NM_001017966.2_1 - 8e-05 22.5 0.0 0.00014 21.7 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease UBA PF00627.29 NM_001017966.2_3 - 0.071 12.9 0.1 8.4 6.3 0.0 2.6 2 0 0 2 2 2 0 UBA/TS-N domain Cadherin PF00028.15 NM_009865.3_1 - 1.6e-78 259.1 6.4 2.8e-19 69.2 0.2 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 NM_009865.3_1 - 3.3e-54 182.6 0.1 6.5e-54 181.7 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 NM_009865.3_1 - 1.4e-07 31.4 4.5 0.0033 17.3 0.2 5.1 5 0 0 5 5 5 2 Cadherin-like Cadherin_2 PF08266.10 NM_009865.3_1 - 0.00027 20.6 0.0 2.5 7.8 0.0 4.0 4 1 0 4 4 4 2 Cadherin-like ASFV_J13L PF05568.9 NM_009865.3_1 - 0.051 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein Cadherin_pro PF08758.9 NM_009865.3_1 - 0.086 12.9 0.0 2.1 8.4 0.0 2.8 2 0 0 2 2 2 0 Cadherin prodomain like KASH_CCD PF14662.4 NM_201374.2_1 - 7.6e-65 218.2 35.0 1.1e-64 217.7 35.0 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH EF-hand_9 PF14658.4 NM_201374.2_1 - 1.1e-27 95.9 0.0 3.1e-27 94.5 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain FlxA PF14282.4 NM_201374.2_1 - 0.0043 16.9 20.7 0.23 11.4 0.8 2.5 2 0 0 2 2 2 2 FlxA-like protein DUF812 PF05667.9 NM_201374.2_1 - 0.005 15.7 21.7 0.0085 14.9 21.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Borrelia_lipo_1 PF05714.9 NM_201374.2_1 - 0.0077 15.9 4.9 0.15 11.6 0.1 2.2 1 1 0 2 2 2 1 Borrelia burgdorferi virulent strain associated lipoprotein Leu_zip PF15294.4 NM_201374.2_1 - 0.011 15.2 25.6 0.19 11.1 9.1 2.2 1 1 1 2 2 2 0 Leucine zipper Fez1 PF06818.13 NM_201374.2_1 - 0.026 14.9 25.0 0.058 13.7 25.0 1.6 1 0 0 1 1 1 0 Fez1 ZapB PF06005.10 NM_201374.2_1 - 0.058 13.7 40.9 1 9.8 1.5 4.8 1 1 3 4 4 4 0 Cell division protein ZapB HMMR_N PF15905.3 NM_201374.2_1 - 0.12 11.7 31.6 0.093 12.0 29.9 1.6 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal IMD PF08397.9 NM_201374.2_1 - 0.12 11.6 15.4 0.21 10.8 15.4 1.3 1 0 0 1 1 1 0 IRSp53/MIM homology domain EF-hand_7 PF13499.4 NM_201374.2_1 - 0.14 12.5 0.0 0.37 11.2 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair DUF3450 PF11932.6 NM_201374.2_1 - 0.18 10.9 30.1 3.2 6.8 23.2 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF5082 PF16888.3 NM_201374.2_1 - 0.21 11.8 17.9 1.4 9.1 10.2 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) TonB_N PF16031.3 NM_201374.2_1 - 0.42 11.0 12.6 1 9.7 12.6 1.6 1 0 0 1 1 1 0 TonB N-terminal region MPS2 PF17060.3 NM_201374.2_1 - 0.42 9.7 7.7 0.72 8.9 7.7 1.3 1 0 0 1 1 1 0 Monopolar spindle protein 2 HAP1_N PF04849.11 NM_201374.2_1 - 0.47 9.5 34.4 1.3 8.1 34.4 1.7 1 0 0 1 1 1 0 HAP1 N-terminal conserved region GldM_N PF12081.6 NM_201374.2_1 - 0.51 10.3 7.3 0.34 10.8 5.2 1.7 1 1 1 2 2 2 0 GldM N-terminal domain DUF4618 PF15397.4 NM_201374.2_1 - 0.62 9.3 25.3 46 3.2 25.3 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) DUF1664 PF07889.10 NM_201374.2_1 - 0.73 9.7 15.5 4.6 7.1 1.4 2.9 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Lebercilin PF15619.4 NM_201374.2_1 - 1 8.8 40.2 1.3 8.5 30.1 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF724 PF05266.12 NM_201374.2_1 - 1 9.0 25.1 5.4 6.7 10.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF2353 PF09789.7 NM_201374.2_1 - 1.2 8.4 27.2 0.016 14.5 10.1 2.1 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) RNase_E_G PF10150.7 NM_201374.2_1 - 1.3 8.2 9.1 2.2 7.5 9.1 1.3 1 0 0 1 1 1 0 Ribonuclease E/G family Rootletin PF15035.4 NM_201374.2_1 - 1.9 8.4 37.7 0.39 10.6 3.7 3.4 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion DUF972 PF06156.11 NM_201374.2_1 - 1.9 9.0 26.8 2.5 8.6 3.0 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF972) AAA_13 PF13166.4 NM_201374.2_1 - 2 6.9 21.0 5.2 5.5 21.0 1.6 1 1 0 1 1 1 0 AAA domain HAUS-augmin3 PF14932.4 NM_201374.2_1 - 2.3 7.5 35.4 0.18 11.2 2.4 3.2 1 1 1 2 2 1 0 HAUS augmin-like complex subunit 3 THOC7 PF05615.11 NM_201374.2_1 - 2.9 8.1 36.4 1.1 9.4 9.3 3.1 1 1 2 3 3 3 0 Tho complex subunit 7 GAS PF13851.4 NM_201374.2_1 - 3 7.0 31.3 9.9 5.3 19.6 2.8 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF342 PF03961.11 NM_201374.2_1 - 3.9 5.8 21.0 1.5 7.2 12.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Spc7 PF08317.9 NM_201374.2_1 - 4 6.1 35.1 5.9 5.5 20.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein MAD PF05557.11 NM_201374.2_1 - 4.2 5.4 33.5 5.7 5.0 11.2 2.2 1 1 1 2 2 2 0 Mitotic checkpoint protein APG6 PF04111.10 NM_201374.2_1 - 5.1 6.3 37.9 0.76 9.0 22.1 3.0 1 1 2 3 3 3 0 Autophagy protein Apg6 XRCC4 PF06632.10 NM_201374.2_1 - 5.2 5.7 23.6 0.066 11.9 12.4 2.2 1 1 1 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF948 PF06103.9 NM_201374.2_1 - 5.4 7.2 6.5 29 4.9 0.0 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4200 PF13863.4 NM_201374.2_1 - 7.7 6.8 33.6 9.5 6.5 9.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Reo_sigmaC PF04582.10 NM_201374.2_1 - 8 5.6 7.9 9.8 5.3 0.2 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein BLOC1_2 PF10046.7 NM_201374.2_1 - 9.7 6.4 20.5 2.3 8.4 5.1 3.2 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 fn3 PF00041.19 NM_008368.4_3 - 0.024 14.8 0.3 0.039 14.2 0.3 1.4 1 0 0 1 1 1 0 Fibronectin type III domain Taxilin PF09728.7 NM_001199695.1_3 - 9.8e-117 389.5 78.3 1.2e-116 389.1 78.3 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein FlaC_arch PF05377.9 NM_001199695.1_3 - 0.33 11.2 15.6 2 8.8 1.4 3.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Bax1-I PF01027.18 NM_078478.5_3 - 8.4e-39 133.4 16.6 8.4e-39 133.4 16.6 1.7 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 VHL PF01847.14 NM_009507.3_1 - 5.8e-39 131.7 0.0 9.9e-39 131.0 0.0 1.4 1 0 0 1 1 1 1 VHL beta domain VHL_C PF17211.1 NM_009507.3_1 - 6.9e-31 105.9 2.5 1.1e-30 105.3 2.5 1.3 1 0 0 1 1 1 1 VHL box domain Lectin_N PF03954.12 NM_010796.3_1 - 2.7e-51 172.6 10.5 2.6e-48 163.0 10.5 2.3 1 1 0 1 1 1 1 Hepatic lectin, N-terminal domain Lectin_C PF00059.19 NM_010796.3_1 - 2.5e-23 82.7 0.5 5.3e-23 81.7 0.5 1.6 1 0 0 1 1 1 1 Lectin C-type domain AIP3 PF03915.11 NM_010796.3_1 - 3.1e-06 26.4 1.3 4.1e-06 26.0 1.3 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 IncA PF04156.12 NM_010796.3_1 - 2.9e-05 23.8 7.6 4.7e-05 23.1 7.6 1.2 1 0 0 1 1 1 1 IncA protein TPR_MLP1_2 PF07926.10 NM_010796.3_1 - 0.00084 19.3 6.7 0.16 11.9 0.1 2.3 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.10 NM_010796.3_1 - 0.00099 19.0 7.6 0.014 15.3 7.6 2.3 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.6 NM_010796.3_1 - 0.0014 16.1 2.7 0.0019 15.7 2.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Atg14 PF10186.7 NM_010796.3_1 - 0.0024 16.9 0.7 0.0034 16.4 0.7 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 APG6 PF04111.10 NM_010796.3_1 - 0.0025 17.1 2.1 0.0034 16.7 2.1 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 KASH_CCD PF14662.4 NM_010796.3_1 - 0.0032 17.2 3.4 0.0057 16.4 3.4 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Seryl_tRNA_N PF02403.20 NM_010796.3_1 - 0.0034 17.5 4.0 0.04 14.0 1.5 2.3 1 1 1 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Fzo_mitofusin PF04799.11 NM_010796.3_1 - 0.0052 16.2 5.1 0.031 13.7 2.7 2.3 1 1 1 2 2 2 1 fzo-like conserved region Reo_sigmaC PF04582.10 NM_010796.3_1 - 0.007 15.7 3.0 0.012 14.9 3.0 1.3 1 0 0 1 1 1 1 Reovirus sigma C capsid protein DASH_Dad2 PF08654.8 NM_010796.3_1 - 0.0076 16.5 2.7 0.041 14.2 0.2 2.7 2 1 1 3 3 2 1 DASH complex subunit Dad2 Apolipoprotein PF01442.16 NM_010796.3_1 - 0.0083 15.9 5.1 0.015 15.1 5.1 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Spc7 PF08317.9 NM_010796.3_1 - 0.011 14.5 2.7 0.019 13.7 2.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.7 NM_010796.3_1 - 0.012 15.8 1.9 0.049 13.8 0.4 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF342 PF03961.11 NM_010796.3_1 - 0.013 14.0 0.7 0.018 13.5 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) bZIP_1 PF00170.19 NM_010796.3_1 - 0.014 15.4 2.4 11 6.1 1.4 3.2 2 1 1 3 3 3 0 bZIP transcription factor Fez1 PF06818.13 NM_010796.3_1 - 0.016 15.5 2.3 0.026 14.9 2.3 1.2 1 0 0 1 1 1 0 Fez1 Leu_zip PF15294.4 NM_010796.3_1 - 0.017 14.5 6.5 0.036 13.5 4.6 2.0 2 0 0 2 2 2 0 Leucine zipper APG17 PF04108.10 NM_010796.3_1 - 0.018 14.1 1.1 0.024 13.6 1.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 Uso1_p115_C PF04871.11 NM_010796.3_1 - 0.018 15.3 5.9 1.5 9.1 0.1 2.2 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Exonuc_VII_L PF02601.13 NM_010796.3_1 - 0.032 13.7 1.5 0.043 13.2 1.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit NPV_P10 PF05531.10 NM_010796.3_1 - 0.033 14.5 1.7 0.033 14.5 1.7 2.4 2 1 2 4 4 2 0 Nucleopolyhedrovirus P10 protein Prefoldin_2 PF01920.18 NM_010796.3_1 - 0.034 14.0 5.3 1.6 8.6 2.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit Tropomyosin_1 PF12718.5 NM_010796.3_1 - 0.036 14.1 6.2 0.079 13.0 5.3 1.8 1 1 1 2 2 2 0 Tropomyosin like IFT57 PF10498.7 NM_010796.3_1 - 0.044 12.6 2.8 0.063 12.1 2.8 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Golgin_A5 PF09787.7 NM_010796.3_1 - 0.045 13.1 4.5 0.065 12.5 4.5 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 FPP PF05911.9 NM_010796.3_1 - 0.048 11.8 5.0 0.11 10.6 5.0 1.5 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil Myosin_tail_1 PF01576.17 NM_010796.3_1 - 0.052 11.2 4.8 0.07 10.8 4.8 1.1 1 0 0 1 1 1 0 Myosin tail CCDC144C PF14915.4 NM_010796.3_1 - 0.053 12.5 5.8 0.093 11.7 5.8 1.3 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region HMMR_N PF15905.3 NM_010796.3_1 - 0.062 12.6 4.4 0.089 12.1 4.4 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Cnn_1N PF07989.9 NM_010796.3_1 - 0.066 13.2 6.6 2.3 8.3 2.0 3.0 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 GAS PF13851.4 NM_010796.3_1 - 0.072 12.3 5.2 5 6.3 1.9 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding RasGAP_C PF03836.13 NM_010796.3_1 - 0.08 13.0 1.4 0.46 10.5 0.7 2.1 1 1 1 2 2 2 0 RasGAP C-terminus Tup_N PF08581.8 NM_010796.3_1 - 0.089 13.0 1.7 0.27 11.4 1.4 2.0 1 1 1 2 2 2 0 Tup N-terminal DUF5082 PF16888.3 NM_010796.3_1 - 0.092 13.0 2.8 2 8.6 1.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) FH2 PF02181.21 NM_010796.3_1 - 0.1 11.6 4.9 0.82 8.6 4.9 2.0 1 1 0 1 1 1 0 Formin Homology 2 Domain CENP-F_leu_zip PF10473.7 NM_010796.3_1 - 0.1 12.5 7.4 1.4 8.8 5.3 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ly49 PF08391.8 NM_010796.3_1 - 0.1 12.8 1.0 6.1 7.1 0.0 2.4 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region DUF4618 PF15397.4 NM_010796.3_1 - 0.12 11.7 3.3 6.7 5.9 2.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) TMF_TATA_bd PF12325.6 NM_010796.3_1 - 0.12 12.4 3.5 0.22 11.6 3.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding UL45 PF05473.10 NM_010796.3_1 - 0.14 11.7 2.8 0.34 10.4 1.4 2.3 2 1 0 2 2 1 0 UL45 protein, carbohydrate-binding C-type lectin-like FUSC PF04632.10 NM_010796.3_1 - 0.14 10.5 0.2 0.19 10.1 0.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family AAA_13 PF13166.4 NM_010796.3_1 - 0.15 10.5 1.8 0.2 10.1 1.8 1.1 1 0 0 1 1 1 0 AAA domain Jnk-SapK_ap_N PF09744.7 NM_010796.3_1 - 0.16 12.1 6.1 0.4 10.8 6.1 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Fib_alpha PF08702.8 NM_010796.3_1 - 0.2 11.7 4.0 0.56 10.3 3.7 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family HAP1_N PF04849.11 NM_010796.3_1 - 0.21 10.6 6.0 0.16 11.0 3.9 1.7 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Filament PF00038.19 NM_010796.3_1 - 0.22 11.0 4.2 0.43 10.0 4.2 1.4 1 1 0 1 1 1 0 Intermediate filament protein CLZ PF16526.3 NM_010796.3_1 - 0.22 11.8 5.6 2.7 8.3 0.3 2.7 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4164 PF13747.4 NM_010796.3_1 - 0.22 11.7 6.5 0.27 11.4 2.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) ApoO PF09769.7 NM_010796.3_1 - 0.22 11.3 0.7 5.3 6.9 0.7 2.4 1 1 0 1 1 1 0 Apolipoprotein O TBPIP PF07106.11 NM_010796.3_1 - 0.23 11.1 8.1 1.6 8.3 3.1 2.4 2 1 1 3 3 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF1664 PF07889.10 NM_010796.3_1 - 0.24 11.3 4.2 1.2 9.0 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PspA_IM30 PF04012.10 NM_010796.3_1 - 0.24 10.8 4.4 0.67 9.4 4.3 1.6 1 1 0 1 1 1 0 PspA/IM30 family FlaC_arch PF05377.9 NM_010796.3_1 - 0.28 11.5 2.2 19 5.6 2.0 3.0 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) TolA_bind_tri PF16331.3 NM_010796.3_1 - 0.36 10.8 5.6 1.7 8.6 1.3 2.6 2 1 0 2 2 2 0 TolA binding protein trimerisation bZIP_2 PF07716.13 NM_010796.3_1 - 0.38 10.7 1.4 2.6 8.1 0.5 2.8 3 0 0 3 3 1 0 Basic region leucine zipper Bacillus_HBL PF05791.9 NM_010796.3_1 - 0.39 10.3 6.9 0.84 9.2 2.3 2.0 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Mnd1 PF03962.13 NM_010796.3_1 - 0.43 10.3 6.0 1.4 8.6 6.3 1.6 1 1 0 1 1 1 0 Mnd1 family ADIP PF11559.6 NM_010796.3_1 - 0.44 10.5 9.7 6.8 6.6 5.5 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Gp58 PF07902.9 NM_010796.3_1 - 0.45 8.8 3.6 0.66 8.2 3.6 1.1 1 0 0 1 1 1 0 gp58-like protein ECM11 PF15463.4 NM_010796.3_1 - 0.47 10.9 3.4 1.6 9.1 0.7 2.7 2 1 1 3 3 2 0 Extracellular mutant protein 11 ACCA PF03255.12 NM_010796.3_1 - 0.48 10.1 2.9 1.7 8.4 0.9 2.5 2 1 1 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CorA PF01544.16 NM_010796.3_1 - 0.56 9.3 3.0 1 8.4 3.0 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF4200 PF13863.4 NM_010796.3_1 - 0.67 10.2 3.2 1 9.6 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Spc24 PF08286.9 NM_010796.3_1 - 0.69 10.0 4.3 1.5 9.0 0.5 2.4 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF2968 PF11180.6 NM_010796.3_1 - 0.71 9.4 4.2 1.2 8.7 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF1640 PF07798.9 NM_010796.3_1 - 0.72 9.7 6.2 10 6.0 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) LPP PF04728.11 NM_010796.3_1 - 0.75 10.1 6.8 1.6 9.0 0.4 3.4 1 1 2 3 3 3 0 Lipoprotein leucine-zipper DivIC PF04977.13 NM_010796.3_1 - 0.85 9.3 4.3 6.3 6.5 0.7 2.7 1 1 2 3 3 3 0 Septum formation initiator DUF4600 PF15372.4 NM_010796.3_1 - 0.85 9.9 5.0 5 7.5 5.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4600) Syntaxin-6_N PF09177.9 NM_010796.3_1 - 1 9.8 5.4 6.3 7.3 1.9 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal HemX PF04375.12 NM_010796.3_1 - 1.1 8.4 7.2 4.5 6.3 7.2 1.8 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase ATG16 PF08614.9 NM_010796.3_1 - 1.1 9.3 8.0 2.2 8.3 8.0 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF2730 PF10805.6 NM_010796.3_1 - 1.2 9.2 3.3 4.6 7.3 2.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DUF3450 PF11932.6 NM_010796.3_1 - 1.4 8.0 5.3 2.9 7.0 4.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) HalX PF08663.8 NM_010796.3_1 - 1.5 9.0 8.4 13 6.1 0.1 2.6 1 1 2 3 3 3 0 HalX domain Fmp27_WPPW PF10359.7 NM_010796.3_1 - 1.8 7.2 5.2 0.55 8.9 1.3 1.8 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Laminin_II PF06009.10 NM_010796.3_1 - 1.9 8.4 5.5 6.5 6.6 5.5 1.8 1 1 0 1 1 1 0 Laminin Domain II PRKG1_interact PF15898.3 NM_010796.3_1 - 2.2 9.1 5.8 22 5.9 0.5 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Phlebovirus_NSM PF07246.9 NM_010796.3_1 - 3.1 7.0 7.8 0.64 9.2 3.1 1.9 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M Bap31 PF05529.10 NM_010796.3_1 - 3.2 7.2 4.9 8 5.9 4.9 1.6 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like TMF_DNA_bd PF12329.6 NM_010796.3_1 - 5.9 6.8 8.1 17 5.3 0.1 2.8 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Syntaxin_2 PF14523.4 NM_010796.3_1 - 9.1 6.6 8.4 4.7 7.5 2.7 2.3 1 1 1 2 2 2 0 Syntaxin-like protein PXA PF02194.13 NM_178623.3_1 - 0.031 14.0 0.2 0.072 12.9 0.0 1.6 2 0 0 2 2 2 0 PXA domain MMR_HSR1 PF01926.21 NM_178623.3_1 - 0.032 14.2 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase ARL2_Bind_BART PF11527.6 NM_024269.4_1 - 5.2e-33 113.5 6.5 7e-33 113.1 6.5 1.2 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART BTB PF00651.29 NM_025991.3_1 - 3.2e-25 88.4 2.1 5.8e-25 87.5 2.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.4 NM_025991.3_1 - 1e-17 63.6 1.0 1.5e-05 25.0 0.0 4.8 3 1 1 4 4 4 3 Kelch motif BACK PF07707.13 NM_025991.3_1 - 1.2e-11 44.5 1.0 8.4e-10 38.5 0.2 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.13 NM_025991.3_1 - 2.7e-08 33.3 0.4 0.0014 18.3 0.2 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.23 NM_025991.3_1 - 3.3e-06 26.4 1.4 0.023 14.2 0.0 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.4 NM_025991.3_1 - 0.0018 18.0 1.0 0.38 10.6 0.0 3.6 3 0 0 3 3 3 1 Galactose oxidase, central domain MMR_HSR1_Xtn PF16897.3 NM_021354.1_1 - 1.4e-46 156.7 0.1 2.5e-46 156.0 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.19 NM_021354.1_1 - 3.6e-24 84.5 0.0 6e-24 83.7 0.0 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.21 NM_021354.1_1 - 3e-19 69.0 0.0 5.9e-19 68.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 NM_021354.1_1 - 2.6e-09 36.6 0.0 4.4e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.21 NM_021354.1_1 - 0.085 12.8 0.3 3.7 7.4 0.0 2.4 1 1 1 2 2 2 0 Dynamin family TPR_12 PF13424.4 NM_001267622.1_1 - 2.5e-113 370.4 113.6 1.6e-12 47.4 1.1 15.3 13 2 2 15 15 15 13 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001267622.1_1 - 9.4e-88 281.7 90.9 4.3e-07 29.4 0.8 25.6 26 0 0 26 26 25 19 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001267622.1_1 - 3.3e-79 257.6 109.9 2.1e-07 30.4 1.9 25.3 25 0 0 25 25 25 22 Tetratricopeptide repeat CHAT PF12770.5 NM_001267622.1_1 - 8.8e-71 238.5 0.2 1.6e-70 237.7 0.2 1.4 1 0 0 1 1 1 1 CHAT domain TPR_2 PF07719.15 NM_001267622.1_1 - 1.4e-47 155.8 108.1 2.5e-06 27.0 1.6 25.3 26 0 0 26 26 26 12 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001267622.1_1 - 1.4e-46 152.6 85.5 7.7e-08 31.8 1.1 24.9 27 0 0 27 27 25 11 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001267622.1_1 - 1e-38 130.0 99.6 6.7e-05 22.5 0.2 24.1 25 0 0 25 25 25 15 Tetratricopeptide repeat Rapsyn_N PF10579.7 NM_001267622.1_1 - 2.9e-12 46.4 19.9 0.22 11.5 0.0 11.7 9 3 3 12 12 11 3 Rapsyn N-terminal myristoylation and linker region TPR_14 PF13428.4 NM_001267622.1_1 - 1.1e-11 44.4 69.6 0.15 12.8 0.5 19.9 21 3 3 24 24 19 3 Tetratricopeptide repeat RPN7 PF10602.7 NM_001267622.1_1 - 3.1e-08 33.4 30.0 0.1 12.1 0.8 8.6 5 2 1 7 7 7 2 26S proteasome subunit RPN7 TPR_11 PF13414.4 NM_001267622.1_1 - 5.4e-08 32.3 57.9 0.00037 20.0 0.1 16.0 15 4 1 16 16 16 2 TPR repeat TPR_19 PF14559.4 NM_001267622.1_1 - 1.3e-05 25.5 64.8 0.26 11.7 0.9 12.1 11 2 2 13 13 12 5 Tetratricopeptide repeat TPR_4 PF07721.12 NM_001267622.1_1 - 1.7e-05 24.9 41.6 2.8 8.7 0.8 15.1 17 0 0 17 17 14 1 Tetratricopeptide repeat TPR_6 PF13174.4 NM_001267622.1_1 - 4.6e-05 23.7 39.7 0.023 15.2 0.1 14.5 15 0 0 15 15 13 1 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001267622.1_1 - 0.0015 18.5 0.1 0.0015 18.5 0.1 10.5 9 4 1 11 11 9 3 Tetratricopeptide repeat TPR_16 PF13432.4 NM_001267622.1_1 - 0.0029 18.1 0.2 0.0029 18.1 0.2 12.3 13 2 1 14 14 12 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001267622.1_1 - 0.0078 16.4 55.4 0.57 10.6 0.9 15.4 17 0 0 17 17 15 2 Tetratricopeptide repeat ANAPC5 PF12862.5 NM_001267622.1_1 - 0.063 13.2 20.6 0.66 9.9 0.2 7.3 6 2 1 7 7 7 0 Anaphase-promoting complex subunit 5 TRAPPC9-Trs120 PF08626.9 NM_001267622.1_1 - 5.1 4.2 5.8 17 2.4 0.3 3.0 1 1 0 3 3 3 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit HisKA_3 PF07730.11 NM_001267622.1_1 - 6.1 7.3 6.0 7.9 7.0 0.0 4.0 4 0 0 4 4 3 0 Histidine kinase WAP PF00095.19 NM_026323.2_2 - 1.5e-18 66.8 40.7 1.8e-10 40.9 16.2 2.4 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' FGF PF00167.16 NM_010202.5_3 - 1.1e-35 122.3 0.0 1.7e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor RUN PF02759.17 NM_001037709.2_2 - 3.6e-21 75.4 0.0 5.5e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 RUN domain SH3_9 PF14604.4 NM_001037709.2_2 - 1e-07 31.5 0.0 2e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_001037709.2_2 - 6.8e-07 28.8 0.0 1.5e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001037709.2_2 - 0.00059 19.3 0.0 0.0011 18.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain LRR_8 PF13855.4 NM_178725.6_1 - 6.1e-53 176.3 59.2 6.3e-14 51.3 2.8 5.3 2 2 5 7 7 7 7 Leucine rich repeat LRR_5 PF13306.4 NM_178725.6_1 - 7.6e-22 77.5 0.0 4.8e-14 52.3 0.1 2.6 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_178725.6_1 - 1.4e-19 69.7 26.7 5e-06 26.6 1.0 6.1 3 1 4 7 7 7 7 Leucine Rich repeats (2 copies) I-set PF07679.14 NM_178725.6_1 - 2e-14 53.2 0.2 4.2e-14 52.2 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_178725.6_1 - 1.2e-11 45.0 2.2 5.8e-11 42.7 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 NM_178725.6_1 - 1.9e-11 43.8 0.2 1.9e-11 43.8 0.2 2.0 2 0 0 2 2 2 1 Immunoglobulin domain LRR_9 PF14580.4 NM_178725.6_1 - 7.2e-08 32.0 9.9 3.4e-06 26.5 1.2 3.0 1 1 2 3 3 3 3 Leucine-rich repeat V-set PF07686.15 NM_178725.6_1 - 2.2e-07 30.9 1.2 1.2e-05 25.3 1.2 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 NM_178725.6_1 - 2.9e-07 30.6 0.2 8.5e-07 29.1 0.2 1.8 1 0 0 1 1 1 1 Immunoglobulin domain LRRNT PF01462.16 NM_178725.6_1 - 0.0016 17.9 2.7 0.0081 15.7 2.7 2.4 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain Podoplanin PF05808.9 NM_178725.6_1 - 0.042 13.9 8.5 0.077 13.0 8.5 1.3 1 0 0 1 1 1 0 Podoplanin LRR_1 PF00560.31 NM_178725.6_1 - 0.55 10.8 32.5 2.9 8.6 0.1 8.5 7 2 1 8 8 8 0 Leucine Rich Repeat KASH PF10541.7 NM_178725.6_1 - 2.3 8.4 9.7 6.9 6.9 0.6 2.8 2 0 0 2 2 2 0 Nuclear envelope localisation domain LRR_6 PF13516.4 NM_178725.6_1 - 6.8 6.9 25.3 4 7.6 0.3 6.9 7 0 0 7 7 7 0 Leucine Rich repeat MFS_1 PF07690.14 NM_001080934.1_2 - 1.9e-38 132.2 29.2 6.7e-29 100.8 19.8 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily ART PF01129.16 NM_001291354.1_3 - 4.4e-93 310.5 0.0 5.5e-93 310.2 0.0 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase V1R PF03402.12 NM_001166836.1_1 - 4.1e-14 52.7 12.5 5.5e-14 52.3 12.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001166836.1_1 - 1.1e-13 50.9 15.7 2e-13 50.0 15.7 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001166836.1_1 - 8.7e-07 28.3 13.8 1.2e-06 27.9 13.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1700 PF08006.9 NM_001166836.1_1 - 0.03 13.7 6.5 0.046 13.1 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Peptidase_M7 PF02031.14 NM_001166836.1_1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family PRP8_domainIV PF12134.6 NM_001166836.1_1 - 0.17 11.4 0.6 0.71 9.3 0.0 2.1 2 1 1 3 3 3 0 PRP8 domain IV core Fer4_4 PF12800.5 NM_001166836.1_3 - 0.67 10.5 0.1 0.67 10.5 0.1 4.2 4 0 0 4 4 4 0 4Fe-4S binding domain Fer4 PF00037.25 NM_001166836.1_3 - 1.2 9.0 8.9 0.58 9.9 1.2 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain BROMI PF14961.4 NM_001033385.3_1 - 0 2336.3 22.3 0 2336.1 22.3 1.0 1 0 0 1 1 1 1 Broad-minded protein ETRAMP PF09716.8 NM_170730.2_1 - 0.011 15.6 0.5 0.99 9.4 0.2 2.8 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) ZU5 PF00791.18 NM_170730.2_2 - 2.4e-33 114.2 0.9 3.7e-27 94.4 0.0 2.4 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 NM_170730.2_2 - 2.5e-21 75.5 0.0 5e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 Death domain NT5C PF06941.10 NM_134029.2_1 - 5.5e-26 91.4 0.0 6.9e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) LBP_BPI_CETP PF01273.23 NM_194357.1_3 - 1.8e-33 115.4 1.1 1.8e-33 115.4 1.1 2.0 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.15 NM_194357.1_3 - 3.7e-20 72.3 2.2 6.2e-20 71.5 2.2 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain TPR_1 PF00515.26 NM_001290563.1_1 - 4e-25 86.4 14.7 7.7e-06 25.4 0.4 8.7 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001290563.1_1 - 6.6e-25 85.1 17.4 0.00013 21.6 0.2 9.5 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_11 PF13414.4 NM_001290563.1_1 - 9.6e-16 57.1 2.7 0.00041 19.9 0.1 7.0 5 3 3 8 8 8 3 TPR repeat TPR_16 PF13432.4 NM_001290563.1_1 - 7.9e-13 48.7 9.3 0.14 12.8 0.1 6.8 5 1 2 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001290563.1_1 - 1.5e-10 41.0 18.8 1.6e-05 24.9 0.2 6.5 4 2 1 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001290563.1_1 - 1.1e-09 37.6 4.4 0.041 14.0 0.0 6.9 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001290563.1_1 - 8.1e-09 35.7 21.1 0.011 16.0 0.3 6.8 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_001290563.1_1 - 9.8e-09 35.1 9.8 0.14 12.2 0.0 5.6 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001290563.1_1 - 3.2e-06 26.7 3.1 0.21 11.6 0.1 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001290563.1_1 - 1.1e-05 25.4 7.6 1.1e-05 25.4 7.6 4.4 4 2 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.4 NM_001290563.1_1 - 2.6e-05 23.4 1.0 0.17 10.9 0.0 4.2 1 1 3 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_001290563.1_1 - 9.1e-05 22.8 10.9 3.9 8.4 0.1 7.2 4 3 3 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001290563.1_1 - 0.38 11.1 13.5 95 3.6 0.0 7.6 7 1 1 8 8 8 0 Tetratricopeptide repeat Cor1 PF04803.10 NM_001290563.1_1 - 0.59 10.2 3.2 0.3 11.2 0.3 2.0 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region TPR_6 PF13174.4 NM_001290563.1_1 - 0.64 10.7 4.9 2.1e+02 2.7 0.0 5.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.7 NM_001290563.1_1 - 0.99 9.0 5.8 3.8 7.1 0.1 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat-like domain AP1AR PF15745.3 NM_145964.2_1 - 3.7e-147 489.1 13.9 4.4e-147 488.9 13.9 1.1 1 0 0 1 1 1 1 AP-1 complex-associated regulatory protein HD PF01966.20 NM_001139520.1_2 - 2.4e-17 63.2 0.0 5.5e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 HD domain SAM_2 PF07647.15 NM_001139520.1_2 - 1.1e-15 57.3 0.0 2.2e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 NM_001139520.1_2 - 2.4e-09 37.4 0.1 6.7e-09 35.9 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF3911 PF13050.4 NM_001139520.1_2 - 0.021 14.8 0.2 8 6.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3911) PDEase_I PF00233.17 NM_001139520.1_2 - 0.028 14.0 0.0 0.057 13.0 0.0 1.5 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase Sec7 PF01369.18 NM_028195.3_2 - 4e-63 212.3 0.0 5.5e-63 211.9 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 NM_028195.3_2 - 3.1e-26 91.8 0.1 5.4e-26 91.0 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_028195.3_2 - 5e-05 23.5 0.1 0.00012 22.3 0.1 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain Syntaxin-6_N PF09177.9 NM_028195.3_2 - 0.0027 18.1 0.8 1.5 9.3 0.0 2.3 2 0 0 2 2 2 2 Syntaxin 6, N-terminal PH_3 PF14593.4 NM_028195.3_2 - 0.022 14.8 0.0 0.054 13.5 0.0 1.6 2 0 0 2 2 2 0 PH domain PH_6 PF15406.4 NM_028195.3_2 - 0.12 12.6 0.1 4 7.6 0.1 2.3 1 1 1 2 2 2 0 Pleckstrin homology domain SLC3A2_N PF16028.3 NM_028195.3_2 - 0.14 11.6 0.0 0.36 10.3 0.0 1.7 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus UQ_con PF00179.24 NM_001302337.1_3 - 8.3e-23 80.5 0.0 1.4e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Collagen PF01391.16 NM_009160.2_3 - 1.7e-30 104.4 102.6 8.4e-09 34.9 27.8 4.4 1 1 1 2 2 2 1 Collagen triple helix repeat (20 copies) Surfac_D-trimer PF09006.9 NM_009160.2_3 - 3.3e-25 87.6 0.1 6.3e-25 86.7 0.1 1.5 1 0 0 1 1 1 1 Lung surfactant protein D coiled-coil trimerisation Lectin_C PF00059.19 NM_009160.2_3 - 1.8e-22 80.0 0.1 2.5e-22 79.5 0.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain DSHCT PF08148.10 NM_021337.2_2 - 1.5e-42 144.9 0.0 3.2e-42 143.8 0.0 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.4 NM_021337.2_2 - 1.7e-37 129.6 0.0 2.3e-37 129.2 0.0 1.2 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.27 NM_021337.2_2 - 4.8e-17 62.2 0.0 8.8e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_021337.2_2 - 7e-06 26.3 0.0 1.4e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_021337.2_2 - 8e-05 22.6 0.0 0.00016 21.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3516 PF12029.6 NM_021337.2_2 - 0.079 11.9 0.1 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) PhoH PF02562.14 NM_021337.2_2 - 0.15 11.4 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein HAS-barrel PF09378.8 NM_021337.2_2 - 0.16 12.0 0.1 0.58 10.2 0.1 1.9 2 0 0 2 2 2 0 HAS barrel domain Reprolysin PF01421.17 NM_001290464.1_2 - 1.5e-12 47.7 0.0 3.3e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease TSP_1 PF00090.17 NM_001290464.1_2 - 1.2e-11 44.5 23.4 1.6e-10 40.9 8.5 8.4 8 1 0 8 8 8 4 Thrombospondin type 1 domain Reprolysin_4 PF13583.4 NM_001290464.1_2 - 4.9e-10 39.3 0.0 8.3e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.4 NM_001290464.1_2 - 8.3e-10 39.1 0.0 1.7e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 NM_001290464.1_2 - 8.6e-06 25.9 0.8 2.1e-05 24.6 0.8 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12 ADAM_spacer1 PF05986.12 NM_001290464.1_2 - 0.0027 17.6 0.0 0.0052 16.7 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin_2 PF13574.4 NM_001290464.1_2 - 0.003 17.4 0.2 0.003 17.4 0.2 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 NM_001290464.1_2 - 0.003 17.3 0.0 0.0053 16.5 0.0 1.3 1 0 0 1 1 1 1 Matrixin Sensor PF13796.4 NM_001290464.1_2 - 0.14 12.0 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Putative sensor Thymosin PF01290.18 NM_001080967.4_3 - 1.4e-18 66.2 8.6 2.1e-18 65.6 8.6 1.3 1 0 0 1 1 1 1 Thymosin beta-4 family bZIP_Maf PF03131.15 NM_001130451.1_2 - 3.7e-17 62.5 7.5 7.1e-17 61.6 7.5 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.19 NM_001130451.1_2 - 4.6e-06 26.5 10.5 9.5e-06 25.5 10.5 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001130451.1_2 - 7.5e-05 22.6 10.8 0.00032 20.6 10.9 2.1 1 1 0 1 1 1 1 Basic region leucine zipper Macoilin PF09726.7 NM_001130451.1_2 - 0.44 8.9 6.2 0.77 8.1 6.2 1.3 1 0 0 1 1 1 0 Transmembrane protein Homeobox PF00046.27 NM_010461.2_3 - 5.6e-21 74.0 5.5 1e-20 73.1 5.5 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_010461.2_3 - 0.028 14.2 0.1 0.057 13.2 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain Hormone_1 PF00103.18 NM_011165.3_3 - 5.5e-69 232.1 5.1 7.1e-69 231.7 5.1 1.1 1 0 0 1 1 1 1 Somatotropin hormone family HATPase_c_4 PF13749.4 NM_011165.3_3 - 0.023 14.7 0.0 0.048 13.7 0.0 1.5 1 0 0 1 1 1 0 Putative ATP-dependent DNA helicase recG C-terminal CUB PF00431.18 NM_029620.2_2 - 5.5e-59 197.2 0.0 2.4e-29 101.8 0.0 2.2 2 0 0 2 2 2 2 CUB domain NTR PF01759.19 NM_029620.2_2 - 6.1e-17 61.2 0.3 1.4e-16 60.0 0.0 1.8 2 0 0 2 2 2 1 UNC-6/NTR/C345C module CUB_2 PF02408.18 NM_029620.2_2 - 4.4e-06 26.3 0.2 0.0095 15.6 0.0 2.6 2 0 0 2 2 2 2 CUB-like domain TIMP PF00965.15 NM_029620.2_2 - 0.047 13.4 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Tissue inhibitor of metalloproteinase Sec23_trunk PF04811.13 NM_001252545.1_1 - 4.4e-80 268.6 0.0 6.2e-80 268.1 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.10 NM_001252545.1_1 - 7.4e-31 106.6 0.0 1.7e-30 105.5 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.13 NM_001252545.1_1 - 1e-25 89.3 0.2 3.3e-25 87.7 0.1 1.9 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Gelsolin PF00626.20 NM_001252545.1_1 - 9.3e-17 60.6 0.0 2.4e-16 59.2 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.13 NM_001252545.1_1 - 5.6e-15 55.0 6.3 1e-14 54.1 6.3 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger APP_E2 PF12925.5 NM_001252545.1_1 - 0.11 12.1 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein DUF3913 PF13052.4 NM_001033786.2_1 - 0.096 12.8 0.1 0.14 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3913) G-gamma PF00631.20 NM_001285910.1_1 - 1.2e-17 63.5 0.0 2e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 GGL domain Lamprin PF06403.9 NM_001285910.1_1 - 0.38 10.6 2.1 0.65 9.8 2.1 1.2 1 0 0 1 1 1 0 Lamprin Lamprin PF06403.9 NM_001285910.1_2 - 0.059 13.2 3.8 0.1 12.4 3.8 1.3 1 0 0 1 1 1 0 Lamprin Lamprin PF06403.9 NM_001285910.1_3 - 0.38 10.6 4.5 0.65 9.8 4.5 1.3 1 0 0 1 1 1 0 Lamprin Ski_Sno PF02437.15 NM_011386.3_3 - 5e-43 145.2 1.8 1e-42 144.2 1.8 1.5 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.8 NM_011386.3_3 - 4e-36 123.0 5.1 1e-35 121.7 5.1 1.8 1 0 0 1 1 1 1 c-SKI Smad4 binding domain DUF489 PF04356.10 NM_011386.3_3 - 0.22 11.4 9.1 0.37 10.6 9.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF489) DUF4407 PF14362.4 NM_011386.3_3 - 5.2 6.2 17.6 10 5.3 17.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF342 PF03961.11 NM_011386.3_3 - 6.2 5.2 14.4 11 4.4 14.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Dynein_IC2 PF11540.6 NM_001191026.1_2 - 1e-14 54.0 0.1 2.2e-14 52.9 0.1 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 NM_001191026.1_2 - 1.6e-06 28.6 9.1 0.16 12.8 0.3 6.4 7 0 0 7 7 7 2 WD domain, G-beta repeat AviRa PF11599.6 NM_001191026.1_2 - 0.13 11.7 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Aa_trans PF01490.16 NM_177074.2_3 - 4e-64 216.7 32.7 4.8e-64 216.4 32.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.11 NM_177074.2_3 - 0.00063 18.8 13.5 0.00063 18.8 13.5 2.1 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family YrhK PF14145.4 NM_177074.2_3 - 0.0021 17.9 0.2 0.0084 16.0 0.2 2.1 1 0 0 1 1 1 1 YrhK-like protein zf-HC5HC2H_2 PF13832.4 NM_001252561.1_2 - 6.7e-31 106.6 19.8 7.7e-30 103.2 11.6 2.5 2 0 0 2 2 2 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 NM_001252561.1_2 - 4.9e-22 77.8 21.1 1.9e-21 75.9 10.6 3.0 3 0 0 3 3 3 2 PHD-like zinc-binding domain PHD_2 PF13831.4 NM_001252561.1_2 - 5.6e-13 48.1 4.2 5.6e-13 48.1 4.2 2.8 2 0 0 2 2 2 1 PHD-finger PHD PF00628.27 NM_001252561.1_2 - 4.7e-08 32.7 9.6 4.7e-08 32.7 9.6 3.6 3 0 0 3 3 3 1 PHD-finger DUF872 PF05915.10 NM_001078649.1_1 - 9.7e-48 161.0 0.1 1.3e-47 160.6 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) DUF308 PF03729.11 NM_001078649.1_1 - 0.16 12.2 6.2 0.31 11.3 6.2 1.4 1 0 0 1 1 1 0 Short repeat of unknown function (DUF308) IncA PF04156.12 NM_001078649.1_1 - 0.22 11.1 5.7 0.33 10.6 5.7 1.2 1 0 0 1 1 1 0 IncA protein DUF3040 PF11239.6 NM_001078649.1_1 - 5.8 7.1 8.0 15 5.8 6.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) DUF4219 PF13961.4 NM_023371.3_1 - 3 7.6 4.3 15 5.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) Rotamase PF00639.19 NM_023371.3_2 - 7.9e-22 77.9 0.0 1.2e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.4 NM_023371.3_2 - 1.2e-19 70.9 0.0 1.8e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.24 NM_023371.3_2 - 2.5e-14 52.8 0.1 7.4e-14 51.3 0.1 1.9 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.4 NM_023371.3_2 - 0.017 15.9 0.0 0.025 15.3 0.0 1.2 1 0 0 1 1 1 0 PPIC-type PPIASE domain PMP22_Claudin PF00822.18 NM_019815.3_2 - 1.7e-25 89.6 14.5 1.7e-25 89.6 14.5 2.3 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 NM_019815.3_2 - 4.1e-08 33.1 14.9 4.1e-08 33.1 14.9 2.6 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Ank_2 PF12796.5 NM_001010836.3_2 - 1.4e-12 47.8 0.2 3.7e-12 46.5 0.2 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) SH3_9 PF14604.4 NM_001010836.3_2 - 2.6e-12 46.2 0.7 4.9e-12 45.4 0.7 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_3 PF13606.4 NM_001010836.3_2 - 3.2e-10 39.2 1.3 0.00041 20.4 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.28 NM_001010836.3_2 - 4e-10 39.6 3.2 0.0002 21.5 0.5 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.4 NM_001010836.3_2 - 1.1e-09 38.4 0.6 1.1e-07 32.1 0.2 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) SH3_1 PF00018.26 NM_001010836.3_2 - 1.2e-09 37.5 0.5 2e-09 36.8 0.5 1.4 1 0 0 1 1 1 1 SH3 domain Ank_5 PF13857.4 NM_001010836.3_2 - 4.1e-09 36.4 3.0 2.2e-05 24.6 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_2 PF07653.15 NM_001010836.3_2 - 2.1e-07 30.4 0.1 3.9e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF2360 PF10152.7 NM_001010836.3_2 - 5.1 7.4 6.2 4.7 7.5 0.7 2.7 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) LELP1 PF15042.4 NM_027042.1_1 - 3.3e-30 104.5 76.6 4.6e-29 100.8 76.6 2.4 1 1 0 1 1 1 1 Late cornified envelope-like proline-rich protein 1 Peptidase_M8 PF01457.14 NM_172823.2_2 - 1.6e-65 221.7 3.3 4e-50 170.9 0.2 3.0 3 0 0 3 3 3 3 Leishmanolysin Acetyltransf_3 PF13302.5 NM_172823.2_2 - 0.13 12.8 0.0 0.28 11.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Eaf7 PF07904.11 NM_028479.1_3 - 7.6e-14 51.8 0.0 1.6e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Chromatin modification-related protein EAF7 Med8 PF10232.7 NM_001290688.1_2 - 2.3e-59 200.7 0.1 3e-59 200.3 0.1 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Med8 PF10232.7 NM_001290688.1_3 - 7.2e-11 42.0 0.1 9.4e-11 41.6 0.1 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Fzo_mitofusin PF04799.11 NM_001285922.1_1 - 9.9e-75 249.3 9.6 7.8e-74 246.4 3.7 2.4 2 0 0 2 2 2 2 fzo-like conserved region Dynamin_N PF00350.21 NM_001285922.1_1 - 5e-23 81.9 0.0 1.2e-22 80.6 0.0 1.7 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.21 NM_001285922.1_1 - 1.5e-06 28.1 0.0 5.2e-06 26.4 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase FXR_C1 PF16096.3 NM_001285922.1_3 - 5.8 7.1 6.1 10 6.3 6.1 1.3 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 DUF3697 PF12478.6 NM_026872.1_3 - 8.7e-17 60.8 4.7 2.8e-15 56.0 0.8 3.0 2 0 0 2 2 2 2 Ubiquitin-associated protein 2 UBA_4 PF14555.4 NM_026872.1_3 - 0.00044 19.9 0.0 0.00079 19.1 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain DUF1296 PF06972.9 NM_026872.1_3 - 0.0044 17.0 0.2 0.01 15.8 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) UBA PF00627.29 NM_026872.1_3 - 0.13 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain HOIP-UBA PF16678.3 NM_026872.1_3 - 0.16 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase DUF1510 PF07423.9 NM_026872.1_3 - 0.87 8.9 5.5 0.1 11.9 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1510) API5 PF05918.9 NM_026872.1_3 - 5.8 5.5 7.1 8.3 5.0 7.1 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Bax1-I PF01027.18 NM_001171035.1_2 - 8.5e-41 139.9 19.1 1.2e-40 139.5 19.1 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 7TMR-DISM_7TM PF07695.9 NM_001171035.1_2 - 1.1 8.9 22.8 0.37 10.5 6.1 2.3 1 1 1 2 2 2 0 7TM diverse intracellular signalling PRY PF13765.4 NM_013483.3_2 - 4.2e-23 80.6 0.4 9.5e-23 79.4 0.4 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 NM_013483.3_2 - 3.3e-18 65.8 0.0 5.5e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 SPRY domain V-set PF07686.15 NM_013483.3_2 - 2.1e-15 56.7 0.0 2.5e-12 46.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_013483.3_2 - 1.2e-11 44.9 0.1 4.2e-05 23.9 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_013483.3_2 - 5.8e-10 39.0 0.0 0.00084 19.2 0.1 2.5 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 NM_013483.3_2 - 1.1e-08 34.9 0.0 7.1e-05 22.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 NM_013483.3_2 - 3.2e-08 33.4 1.0 1.8e-07 31.0 0.3 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 NM_013483.3_2 - 5.4e-05 23.3 0.0 0.012 15.8 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.3 NM_013483.3_2 - 0.12 12.3 0.0 0.36 10.8 0.0 1.7 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Glyco_hydro_15 PF00723.19 NM_199446.1_1 - 2e-108 363.0 0.0 2.5e-108 362.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 A_deamin PF02137.16 NM_001289530.1_2 - 9.4e-92 307.8 0.0 1.4e-91 307.2 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 NM_001289530.1_2 - 7.2e-22 77.7 2.3 7.7e-11 42.4 0.0 3.4 3 0 0 3 3 3 2 Double-stranded RNA binding motif A_deamin PF02137.16 NM_001289530.1_3 - 1.6e-06 27.7 0.0 2.3e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Abhydrolase_1 PF00561.18 NM_001110272.1_1 - 2.8e-09 36.8 0.1 0.00019 21.0 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_001110272.1_1 - 9e-06 26.3 2.2 0.0055 17.2 0.0 2.4 1 1 1 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 NM_001110272.1_1 - 0.00013 21.2 0.1 0.6 9.2 0.0 2.9 1 1 1 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.11 NM_001110272.1_1 - 0.0031 17.1 0.1 0.0068 16.0 0.0 1.5 2 0 0 2 2 2 1 Serine hydrolase (FSH1) DLH PF01738.16 NM_001110272.1_1 - 0.18 11.2 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family RRM_1 PF00076.20 NM_001172147.1_3 - 1.2e-07 31.3 0.0 2.3e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RPA_interact_N PF14766.4 NM_027186.2_2 - 5.1e-18 64.4 2.0 5.1e-18 64.4 2.0 2.0 2 0 0 2 2 2 1 Replication protein A interacting N-terminal RPA_interact_C PF14768.4 NM_027186.2_2 - 7.2e-18 64.8 5.0 1.5e-17 63.8 5.0 1.5 1 0 0 1 1 1 1 Replication protein A interacting C-terminal RPA_interact_M PF14767.4 NM_027186.2_2 - 2.4e-11 43.9 10.0 4.1e-11 43.2 10.0 1.4 1 0 0 1 1 1 1 Replication protein A interacting middle eIF-5a PF01287.18 NM_001166596.1_1 - 4.4e-25 87.4 0.2 6.5e-25 86.9 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.10 NM_001166596.1_1 - 0.02 14.8 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain TCL1_MTCP1 PF01840.15 NM_013775.1_1 - 1.6e-32 111.4 0.2 2.2e-32 111.0 0.2 1.2 1 0 0 1 1 1 1 TCL1/MTCP1 family Pkinase PF00069.23 NM_009974.3_2 - 5.5e-70 235.6 0.9 7e-70 235.3 0.9 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_009974.3_2 - 1.1e-19 70.6 0.1 1.6e-19 70.1 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_009974.3_2 - 6.2e-09 36.0 0.0 6.5e-06 26.1 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 NM_009974.3_2 - 0.027 13.7 0.1 0.046 12.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.18 NM_009974.3_2 - 0.12 11.8 0.3 0.22 11.0 0.3 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase COX7a PF02238.13 NM_009944.3_1 - 5.3e-09 36.2 0.0 8.6e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Methyltransf_23 PF13489.4 NM_080462.2_2 - 6.3e-16 58.6 0.0 9.5e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 NM_080462.2_2 - 4.5e-05 24.0 0.0 8.2e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain YAF2_RYBP PF17219.1 NM_019743.3_1 - 1.4e-19 69.1 1.2 2.5e-19 68.3 1.2 1.4 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif zf-RanBP PF00641.16 NM_019743.3_1 - 2e-07 30.0 4.4 3.2e-07 29.4 2.4 2.4 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others IQ PF00612.25 NM_198026.2_3 - 0.001 18.6 0.3 0.0022 17.5 0.3 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif Pkinase PF00069.23 NM_001277898.1_2 - 6.1e-72 242.0 0.0 7.4e-72 241.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001277898.1_2 - 1.8e-33 115.8 0.0 2.5e-33 115.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001277898.1_2 - 4.6e-08 32.6 0.0 6.3e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Apolipo_F PF15148.4 NM_133996.3_1 - 6.4e-72 241.1 0.0 8.3e-72 240.8 0.0 1.1 1 0 0 1 1 1 1 Apolipoprotein F IGR PF09597.8 NM_133996.3_1 - 0.021 14.8 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 IGR protein motif DUF4683 PF15735.3 NM_011264.3_1 - 8.5e-159 529.3 11.4 8.5e-159 529.3 11.4 4.6 4 1 1 5 5 5 1 Domain of unknown function (DUF4683) DNA_pol_B PF00136.19 NM_011264.3_1 - 2.5e-101 339.5 0.0 4e-101 338.9 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.17 NM_011264.3_1 - 4.5e-28 98.2 0.1 6.6e-16 58.2 0.1 2.6 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.4 NM_011264.3_1 - 1.9e-13 50.5 6.2 1.9e-13 50.5 6.2 4.0 4 1 1 5 5 5 1 C4-type zinc-finger of DNA polymerase delta SH3_1 PF00018.26 NM_010815.3_3 - 1.6e-28 97.9 0.1 1.1e-13 50.4 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 NM_010815.3_3 - 1.1e-26 92.3 0.1 8.1e-13 47.9 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.22 NM_010815.3_3 - 2.2e-20 72.4 0.1 3.5e-20 71.7 0.1 1.3 1 0 0 1 1 1 1 SH2 domain SH3_2 PF07653.15 NM_010815.3_3 - 1.1e-16 60.1 0.0 8.6e-09 34.8 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH2_2 PF14633.4 NM_010815.3_3 - 0.0066 15.7 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 SH2 domain 7tm_4 PF13853.4 NM_206822.1_1 - 1.8e-47 162.3 8.9 2.3e-47 161.9 8.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_206822.1_1 - 3.6e-23 82.0 10.9 7.8e-23 80.9 10.9 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_206822.1_1 - 3.8e-06 26.3 3.3 3.8e-06 26.3 3.3 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 NM_206822.1_1 - 0.0085 15.5 5.4 0.015 14.7 5.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc ABC_tran PF00005.25 NM_026458.4_3 - 4.2e-58 195.6 0.0 4.4e-31 108.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.5 NM_026458.4_3 - 4.4e-56 190.3 51.0 1.3e-34 119.7 25.2 2.6 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.4 NM_026458.4_3 - 4e-20 72.7 2.0 4.9e-06 26.4 0.0 4.4 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 NM_026458.4_3 - 9.2e-06 26.2 1.2 0.0074 16.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.17 NM_026458.4_3 - 7.3e-05 22.2 0.0 0.88 8.8 0.0 3.4 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 NM_026458.4_3 - 0.00065 19.2 0.7 0.094 12.3 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF258 PF03193.14 NM_026458.4_3 - 0.0019 18.0 0.1 0.068 12.9 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 SRP54 PF00448.20 NM_026458.4_3 - 0.002 17.6 3.2 0.088 12.3 0.1 2.3 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_30 PF13604.4 NM_026458.4_3 - 0.013 15.0 0.1 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC2_membrane PF01061.22 NM_026458.4_3 - 0.033 13.5 53.6 0.0068 15.7 19.5 4.4 4 0 0 4 4 4 0 ABC-2 type transporter Pheromone PF08015.9 NM_026458.4_3 - 0.1 13.5 0.1 0.3 12.0 0.1 1.7 1 0 0 1 1 1 0 Fungal mating-type pheromone Arf PF00025.19 NM_026458.4_3 - 0.11 11.8 0.5 2.6 7.3 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_15 PF13175.4 NM_026458.4_3 - 0.73 9.2 11.5 0.49 9.8 0.1 4.0 5 0 0 5 5 5 0 AAA ATPase domain PDE6_gamma PF04868.10 NM_001310716.1_3 - 0.76 9.9 2.9 1.7 8.8 2.9 1.6 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit Ribosomal_60s PF00428.17 NM_001310716.1_3 - 6.7 7.2 11.4 11 6.5 11.4 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein zf-CW PF07496.13 NM_029413.4_3 - 4e-16 58.7 3.6 4e-16 58.7 3.6 2.1 2 0 0 2 2 2 1 CW-type Zinc Finger HATPase_c_3 PF13589.4 NM_029413.4_3 - 1.4e-15 57.2 0.0 3.7e-15 55.8 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 NM_029413.4_3 - 1.4e-07 32.0 0.0 2.6e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CENP-F_leu_zip PF10473.7 NM_029413.4_3 - 0.0036 17.2 18.3 0.0036 17.2 18.3 1.9 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6 PF04111.10 NM_029413.4_3 - 0.026 13.8 15.8 0.058 12.6 15.8 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 V_ATPase_I PF01496.17 NM_029413.4_3 - 0.12 10.1 6.2 0.22 9.2 6.2 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-H2C2_2 PF13465.4 NM_011760.2_2 - 4.1e-74 241.8 144.6 5.3e-09 36.0 0.8 16.3 16 0 0 16 16 16 15 Zinc-finger double domain zf-C2H2 PF00096.24 NM_011760.2_2 - 1.6e-56 185.6 138.6 1.2e-06 28.5 1.4 14.6 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_011760.2_2 - 1.2e-28 97.2 142.7 0.0032 18.0 1.0 14.6 16 0 0 16 16 16 13 C2H2-type zinc finger KRAB PF01352.25 NM_011760.2_2 - 1.2e-22 79.2 1.7 2.3e-22 78.2 1.7 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_011760.2_2 - 8.6e-18 63.7 111.2 0.0012 18.6 2.7 14.4 14 1 0 14 14 14 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_011760.2_2 - 7.5e-09 35.4 67.1 0.036 14.0 3.3 10.4 5 3 5 11 11 11 6 Zinc ribbon domain BolA PF01722.16 NM_011760.2_2 - 0.002 18.2 21.6 1.1 9.4 0.0 6.8 5 2 1 6 6 6 1 BolA-like protein zf-C2H2_jaz PF12171.6 NM_011760.2_2 - 0.013 15.7 2.5 0.09 13.0 0.2 13.4 12 1 1 13 13 13 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 NM_011760.2_2 - 0.014 15.0 1.7 0.014 15.0 1.7 14.2 14 3 0 14 14 14 0 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.3 NM_011760.2_2 - 0.27 10.9 93.7 0.1 12.2 0.6 13.5 14 0 0 14 14 14 0 zinc-finger C2H2-type Baculo_LEF-11 PF06385.10 NM_011760.2_3 - 0.13 12.6 20.6 0.6 10.5 1.1 5.4 3 1 1 5 5 5 0 Baculovirus LEF-11 protein EIF4E-T PF10477.7 NM_001166549.1_1 - 5.2e-168 560.7 11.1 5.2e-168 560.7 11.1 2.2 2 0 0 2 2 2 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E COesterase PF00135.26 NM_133960.5_1 - 1.2e-164 548.9 0.0 1.4e-164 548.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 NM_133960.5_1 - 7.9e-10 38.8 0.2 3.4e-09 36.7 0.2 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_133960.5_1 - 5.6e-06 25.8 0.0 8.5e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Defensin_beta PF00711.17 NM_183039.3_1 - 4.2e-11 42.6 9.3 4.2e-11 42.6 9.3 1.9 2 0 0 2 2 2 1 Beta defensin Herpes_UL49_1 PF03117.12 NM_183039.3_2 - 0.18 10.9 2.3 0.23 10.6 1.9 1.4 1 1 1 2 2 2 0 UL49 family Pkinase_Tyr PF07714.15 NM_001111030.1_1 - 3.3e-31 108.4 0.1 4.5e-31 107.9 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001111030.1_1 - 1.3e-29 103.2 0.0 1.9e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 NM_001111030.1_1 - 1e-14 53.6 0.1 2e-14 52.6 0.1 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Ldl_recept_a PF00057.16 NM_001033979.1_1 - 1.4e-05 25.1 5.4 3.8e-05 23.7 5.4 1.7 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A 7tm_1 PF00001.19 NM_010935.3_3 - 2.2e-49 167.9 23.5 3.3e-49 167.4 23.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Peptidase_A22B PF04258.11 NM_010935.3_3 - 0.0044 16.4 8.5 0.0044 16.4 8.5 2.1 2 1 0 2 2 2 1 Signal peptide peptidase Ras PF00071.20 NM_029781.3_3 - 9.6e-44 148.7 0.3 1.3e-43 148.3 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_029781.3_3 - 4.5e-28 97.8 0.1 6.6e-28 97.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_029781.3_3 - 1.5e-14 53.7 0.0 2.4e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_029781.3_3 - 1.7e-05 24.7 0.0 2.7e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_029781.3_3 - 0.0034 16.7 0.0 0.0046 16.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Myb_DNA-bind_4 PF13837.4 NM_146222.2_1 - 2.2e-21 75.9 0.0 4.5e-21 74.9 0.0 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain F-112 PF09645.8 NM_146222.2_1 - 0.085 13.0 0.1 6.7 7.0 0.2 2.3 2 0 0 2 2 2 0 F-112 protein MADF_DNA_bdg PF10545.7 NM_146222.2_1 - 0.09 13.0 0.1 0.09 13.0 0.1 2.3 4 0 0 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF4525 PF15027.4 NM_175098.6_3 - 1.7e-71 238.2 1.1 2.6e-71 237.6 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4525) TCR_zetazeta PF11628.6 NM_031162.4_2 - 9.5e-18 63.4 1.5 1.6e-17 62.7 1.5 1.4 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain ITAM PF02189.13 NM_031162.4_2 - 5.9e-11 42.0 4.8 0.00013 22.1 0.8 3.0 3 0 0 3 3 3 2 Immunoreceptor tyrosine-based activation motif Thiolase_N PF00108.21 NM_145558.2_3 - 9.5e-89 297.1 0.2 1.4e-88 296.5 0.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 NM_145558.2_3 - 1.2e-49 166.9 0.0 2.4e-49 166.0 0.0 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 NM_145558.2_3 - 4e-09 36.3 0.7 2.8e-08 33.5 0.2 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.8 NM_145558.2_3 - 0.046 13.4 1.4 0.39 10.5 0.3 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SpoVAD PF07451.9 NM_145558.2_3 - 0.074 11.6 0.1 0.15 10.6 0.1 1.4 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) MoCF_biosynth PF00994.22 NM_177041.3_1 - 8e-29 100.0 0.0 1.3e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain PAPS_reduct PF01507.17 NM_177041.3_1 - 3.1e-25 89.1 0.0 6.5e-23 81.5 0.0 2.3 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family 14-3-3 PF00244.18 NM_018871.3_2 - 6.2e-105 349.5 10.7 7.8e-105 349.1 10.7 1.1 1 0 0 1 1 1 1 14-3-3 protein Bromodomain PF00439.23 NM_001081251.1_3 - 1.3e-111 364.8 25.7 9.3e-23 80.0 0.1 6.5 6 0 0 6 6 6 6 Bromodomain BAH PF01426.16 NM_001081251.1_3 - 4.3e-50 168.5 3.2 2.8e-28 98.0 1.3 2.7 2 0 0 2 2 2 2 BAH domain HMG_box PF00505.17 NM_001081251.1_3 - 2.8e-14 53.1 0.6 2.8e-14 53.1 0.6 2.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_001081251.1_3 - 4.1e-10 40.0 2.0 1.2e-09 38.4 2.0 1.8 1 0 0 1 1 1 1 HMG-box domain PLDc_3 PF13918.4 NM_011116.2_2 - 1.7e-41 141.7 0.0 3e-40 137.6 0.0 2.1 2 0 0 2 2 2 1 PLD-like domain PLDc_2 PF13091.4 NM_011116.2_2 - 5.2e-28 97.4 0.0 1.2e-17 63.9 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.20 NM_011116.2_2 - 2.7e-10 39.9 6.0 2.1e-08 33.9 0.5 2.7 3 0 0 3 3 3 2 Phospholipase D Active site motif DUF1241 PF06840.9 NM_019745.4_3 - 2.3e-62 209.0 3.4 3.2e-62 208.5 3.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Syntaxin_2 PF14523.4 NM_019745.4_3 - 0.59 10.4 4.6 1.2 9.4 4.6 1.5 1 1 0 1 1 1 0 Syntaxin-like protein p450 PF00067.20 NM_001011707.1_2 - 4.4e-156 520.1 0.0 5e-156 519.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CRF PF00473.15 NM_205769.3_2 - 5.5e-16 58.3 1.1 1.1e-15 57.3 1.1 1.6 1 0 0 1 1 1 1 Corticotropin-releasing factor family Neuropep_like PF15161.4 NM_205769.3_2 - 0.13 11.8 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 Neuropeptide-like FYVE_2 PF02318.14 NM_001039364.2_1 - 3e-10 40.2 6.7 7e-10 39.0 6.7 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger ECH_1 PF00378.18 NM_011868.3_2 - 4.1e-40 137.6 0.0 5.8e-40 137.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ACBP PF00887.17 NM_011868.3_2 - 4.4e-30 103.6 0.0 9.3e-30 102.6 0.0 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein ECH_2 PF16113.3 NM_011868.3_2 - 6.9e-19 68.4 0.0 9.6e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase FAM131 PF15010.4 NM_001286584.1_1 - 1.6e-110 369.5 5.6 2.4e-110 368.9 5.6 1.3 1 0 0 1 1 1 1 Putative cell signalling 7tm_4 PF13853.4 NM_146578.2_1 - 1.7e-48 165.7 17.6 2.5e-48 165.1 17.6 1.3 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146578.2_1 - 9.3e-20 70.8 15.8 9.3e-20 70.8 15.8 2.0 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) FAM91_C PF14648.4 NM_145959.3_2 - 4.7e-178 592.3 0.0 6.8e-178 591.8 0.0 1.2 1 0 0 1 1 1 1 FAM91 C-terminus FAM91_N PF14647.4 NM_145959.3_2 - 2.6e-145 483.4 0.8 3.4e-145 483.0 0.8 1.1 1 0 0 1 1 1 1 FAM91 N-terminus Peptidase_M24 PF00557.22 NM_133216.3_2 - 1.5e-49 168.4 0.0 2.2e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.3 NM_133216.3_2 - 1.7e-45 154.8 0.0 2.8e-45 154.1 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.3 NM_133216.3_2 - 3.5e-23 81.3 0.1 1.1e-22 79.7 0.1 2.0 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.16 NM_133216.3_2 - 2.3e-14 54.0 0.0 1e-11 45.4 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain 7tm_3 PF00003.20 NM_001104632.1_1 - 1.2e-55 188.7 34.1 1.2e-55 188.7 34.1 1.7 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001104632.1_1 - 8.1e-34 117.1 0.0 1.1e-33 116.6 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001104632.1_1 - 3.1e-20 71.7 10.9 3.1e-20 71.7 10.9 1.7 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR PGG PF13962.4 NM_001104632.1_1 - 0.011 15.4 0.4 0.011 15.4 0.4 2.9 2 1 1 3 3 3 0 Domain of unknown function COPI_C PF06957.9 NM_001104632.1_1 - 0.092 11.4 1.2 0.15 10.7 1.2 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus UDPGT PF00201.16 NM_152811.1_3 - 3.4e-257 854.0 0.1 4.2e-257 853.7 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 NM_152811.1_3 - 4.3e-05 23.4 0.0 7.1e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Peptidase_S8 PF00082.20 NM_008792.4_2 - 7.7e-41 140.2 1.6 9.9e-41 139.8 1.6 1.1 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.18 NM_008792.4_2 - 4e-25 87.5 0.1 7e-25 86.8 0.1 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.3 NM_008792.4_2 - 2.4e-18 66.6 2.9 5.8e-18 65.4 2.9 1.7 1 0 0 1 1 1 1 Peptidase S8 pro-domain Peptidase_S8_N PF16361.3 NM_008792.4_2 - 0.15 12.4 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 N-terminal of Subtilase family Connexin PF00029.17 NM_010291.3_2 - 7e-77 258.1 8.4 3.3e-76 255.9 8.4 1.8 1 1 0 1 1 1 1 Connexin DUF35_N PF12172.6 NM_010291.3_2 - 0.013 15.2 0.1 0.044 13.5 0.1 1.8 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF912 PF06024.10 NM_010291.3_2 - 0.09 13.0 0.8 0.35 11.1 0.1 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) zf-piccolo PF05715.11 NM_011995.4_2 - 7e-57 189.3 32.7 1.1e-29 102.2 12.6 2.5 2 0 0 2 2 2 2 Piccolo Zn-finger C2 PF00168.28 NM_011995.4_2 - 4e-37 126.5 0.5 1.4e-22 79.8 0.1 2.6 2 0 0 2 2 2 2 C2 domain PDZ PF00595.22 NM_011995.4_2 - 2.7e-07 30.7 0.3 8.3e-07 29.1 0.3 1.9 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FYVE_2 PF02318.14 NM_011995.4_2 - 3.2e-05 24.0 13.2 0.00013 22.0 3.4 4.2 5 0 0 5 5 5 2 FYVE-type zinc finger zf-Dof PF02701.13 NM_011995.4_2 - 6.5 6.9 8.3 0.66 10.0 0.8 2.5 2 0 0 2 2 2 0 Dof domain, zinc finger Filament PF00038.19 NM_010666.2_1 - 9.3e-101 337.4 21.4 1.2e-100 336.9 21.4 1.2 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 NM_010666.2_1 - 0.00021 21.2 1.8 0.00021 21.2 1.8 4.2 3 1 1 4 4 4 3 TPR/MLP1/MLP2-like protein ATG16 PF08614.9 NM_010666.2_1 - 0.01 15.9 28.6 0.25 11.4 2.8 4.5 4 1 1 5 5 5 0 Autophagy protein 16 (ATG16) IncA PF04156.12 NM_010666.2_1 - 0.014 15.1 25.9 0.54 9.9 0.0 4.2 2 1 2 4 4 4 0 IncA protein DUF2312 PF10073.7 NM_010666.2_1 - 0.066 12.7 0.1 1 8.9 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) DUF4407 PF14362.4 NM_010666.2_1 - 0.28 10.4 18.5 1.4 8.1 1.0 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) DUF1664 PF07889.10 NM_010666.2_1 - 0.87 9.4 17.6 0.41 10.5 0.8 5.0 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.10 NM_010666.2_1 - 1.2 8.4 9.6 0.5 9.6 3.1 2.6 2 1 0 3 3 3 0 Reovirus sigma C capsid protein Bacillus_HBL PF05791.9 NM_010666.2_1 - 1.7 8.2 14.0 0.033 13.8 2.8 3.1 3 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DUF4446 PF14584.4 NM_010666.2_1 - 1.7 8.4 10.7 1.8 8.4 0.0 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) Mod_r PF07200.11 NM_010666.2_1 - 2.1 8.3 25.5 1.9 8.4 0.0 4.2 3 1 1 4 4 4 0 Modifier of rudimentary (Mod(r)) protein Lectin_N PF03954.12 NM_010666.2_1 - 3.7 7.2 13.2 72 3.0 7.8 4.1 3 1 1 4 4 4 0 Hepatic lectin, N-terminal domain DivIC PF04977.13 NM_010666.2_1 - 5.8 6.6 24.3 0.81 9.4 0.2 5.2 5 1 1 6 6 6 0 Septum formation initiator Phage_Mu_Gam PF07352.10 NM_010666.2_1 - 6 6.6 23.1 1.2 8.8 2.9 4.0 3 1 0 4 4 4 0 Bacteriophage Mu Gam like protein Prefoldin_2 PF01920.18 NM_010666.2_1 - 7 6.6 30.9 2.1 8.2 2.5 5.6 5 1 0 5 5 5 0 Prefoldin subunit 7tm_3 PF00003.20 NM_001105061.1_1 - 1.9e-55 188.0 27.4 4e-55 187.0 27.4 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001105061.1_1 - 5.2e-41 140.8 0.1 7.5e-41 140.3 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001105061.1_1 - 3.1e-20 71.7 12.9 6.2e-20 70.8 12.9 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DctQ PF04290.10 NM_001105061.1_1 - 5.5 6.8 11.1 0.25 11.1 0.3 3.0 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component EGF PF00008.25 NM_010929.2_2 - 6.4e-130 422.7 439.5 3.9e-08 33.3 3.7 30.6 30 0 0 30 30 28 28 EGF-like domain hEGF PF12661.5 NM_010929.2_2 - 5.7e-76 248.7 379.0 1.3e-06 28.7 7.1 33.2 31 1 0 31 31 28 27 Human growth factor-like EGF EGF_CA PF07645.13 NM_010929.2_2 - 5.7e-40 135.1 358.5 3.9e-09 36.4 4.1 30.3 15 8 15 30 30 25 16 Calcium-binding EGF domain Ank PF00023.28 NM_010929.2_2 - 6e-28 95.9 0.5 0.0023 18.2 0.0 6.8 6 0 0 6 6 6 6 Ankyrin repeat Ank_2 PF12796.5 NM_010929.2_2 - 8.8e-28 96.6 0.2 1.3e-13 51.2 0.1 4.3 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_010929.2_2 - 7.7e-27 92.8 16.2 1.2e-07 31.8 0.1 5.8 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Notch PF00066.15 NM_010929.2_2 - 2.1e-22 79.1 47.7 1.1e-10 41.6 13.4 10.5 10 1 0 10 10 3 3 LNR domain Ank_3 PF13606.4 NM_010929.2_2 - 1.4e-21 74.1 0.1 0.00028 20.9 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.4 NM_010929.2_2 - 4.7e-20 71.6 0.2 2.9e-07 30.7 0.0 4.2 1 1 1 3 3 3 3 Ankyrin repeats (many copies) EGF_2 PF07974.11 NM_010929.2_2 - 8.4e-12 45.1 488.5 0.002 18.3 12.2 32.1 32 1 0 32 32 29 18 EGF-like domain NODP PF07684.10 NM_010929.2_2 - 5.8e-11 42.2 0.0 4e-10 39.5 0.0 2.7 1 0 0 1 1 1 1 NOTCH protein NOD PF06816.11 NM_010929.2_2 - 0.00064 19.2 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 NOTCH protein EGF_3 PF12947.5 NM_010929.2_2 - 0.0026 17.8 1.1 0.0026 17.8 1.1 30.8 28 2 2 30 30 29 14 EGF domain cEGF PF12662.5 NM_010929.2_2 - 0.0078 16.0 0.6 0.0078 16.0 0.6 29.5 29 1 0 29 29 26 6 Complement Clr-like EGF-like Kunitz_BPTI PF00014.21 NM_001276431.1_2 - 3.3e-19 68.7 6.2 3.3e-19 68.7 6.2 2.8 3 1 0 3 3 3 1 Kunitz/Bovine pancreatic trypsin inhibitor domain WAP PF00095.19 NM_001276431.1_2 - 4.1e-13 49.4 36.1 1.1e-07 32.0 14.3 3.7 4 2 1 5 5 5 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' Peptidase_C50 PF03568.15 NM_001014976.2_1 - 5.1e-90 302.3 0.0 1.1e-89 301.2 0.0 1.6 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.5 NM_001014976.2_1 - 0.00085 18.7 2.0 0.57 9.4 0.4 2.6 1 1 0 2 2 2 2 CHAT domain TPR_2 PF07719.15 NM_001014976.2_1 - 0.68 10.1 5.2 24 5.2 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.10 NM_001014976.2_1 - 0.89 9.5 3.3 8 6.4 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat MAS20 PF02064.13 NM_029227.1_3 - 1.6e-31 108.9 0.0 2.8e-31 108.2 0.0 1.3 1 0 0 1 1 1 1 MAS20 protein import receptor Trp_oprn_chp PF09534.8 NM_029227.1_3 - 0.16 11.6 0.2 0.21 11.2 0.2 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) EOS1 PF12326.6 NM_009787.2_1 - 0.14 11.9 0.2 0.19 11.5 0.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein Zip PF02535.20 NM_009787.2_1 - 0.58 9.2 1.7 0.78 8.8 1.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter 7tm_1 PF00001.19 NM_009787.2_1 - 1.6 7.8 5.1 2.5 7.1 5.1 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Thioredoxin PF00085.18 NM_009787.2_2 - 1.5e-98 323.6 0.2 2e-31 107.8 0.0 3.8 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.4 NM_009787.2_2 - 7.2e-25 87.9 6.3 3.7e-17 62.8 1.9 4.7 4 0 0 4 4 4 3 Thioredoxin-like domain OST3_OST6 PF04756.11 NM_009787.2_2 - 2.3e-15 56.6 0.0 6.4e-05 22.3 0.0 3.7 3 0 0 3 3 3 3 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.4 NM_009787.2_2 - 9.7e-15 54.6 0.3 0.0063 16.7 0.0 6.5 4 2 2 6 6 6 3 Thioredoxin-like Thioredoxin_2 PF13098.4 NM_009787.2_2 - 2.1e-14 53.8 2.0 0.0014 18.9 0.0 4.7 3 1 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_7 PF13899.4 NM_009787.2_2 - 3.2e-13 49.5 0.1 0.013 15.5 0.0 4.5 5 0 0 5 5 4 3 Thioredoxin-like Calsequestrin PF01216.15 NM_009787.2_2 - 2.2e-11 43.3 3.3 7.1e-09 35.0 0.0 3.2 1 1 1 3 3 3 2 Calsequestrin AhpC-TSA PF00578.19 NM_009787.2_2 - 1.7e-08 34.3 0.1 0.065 13.0 0.0 3.8 4 0 0 4 4 3 2 AhpC/TSA family Redoxin PF08534.8 NM_009787.2_2 - 3.6e-05 23.3 1.1 3.6 7.1 0.0 4.4 5 0 0 5 5 5 1 Redoxin Ribosomal_60s PF00428.17 NM_009787.2_2 - 0.0036 17.7 3.6 0.0036 17.7 3.6 3.7 2 1 0 2 2 1 1 60s Acidic ribosomal protein HyaE PF07449.9 NM_009787.2_2 - 0.016 15.0 0.0 12 5.8 0.0 3.7 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE TraF PF13728.4 NM_009787.2_2 - 0.045 13.5 29.6 0.073 12.8 0.0 5.1 5 0 0 5 5 4 0 F plasmid transfer operon protein EOS1 PF12326.6 NM_009787.2_2 - 0.14 12.0 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 N-glycosylation protein CPSF100_C PF13299.4 NM_009787.2_2 - 0.28 11.2 10.7 2.6 8.1 7.9 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Afi1 PF07792.10 NM_009787.2_2 - 0.46 10.8 8.8 0.14 12.5 0.7 2.5 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PMC2NT PF08066.10 NM_009787.2_2 - 0.59 10.7 4.6 0.9 10.1 0.0 3.3 3 0 0 3 3 3 0 PMC2NT (NUC016) domain Connexin PF00029.17 NM_009787.2_3 - 0.0088 15.7 5.2 0.013 15.2 5.2 1.2 1 0 0 1 1 1 1 Connexin DUF4834 PF16118.3 NM_009787.2_3 - 0.12 13.3 8.3 0.19 12.6 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Zip PF02535.20 NM_009787.2_3 - 0.13 11.4 1.1 0.17 10.9 1.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Eapp_C PF10238.7 NM_009787.2_3 - 7.2 6.5 14.6 11 6.0 14.6 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF4515 PF14988.4 NM_146059.2_3 - 1.9e-22 80.0 24.6 1.9e-22 80.0 24.6 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4515) 7tm_1 PF00001.19 NM_001122595.1_3 - 8.4e-34 116.9 21.7 8.4e-34 116.9 21.7 2.1 3 0 0 3 3 3 1 7 transmembrane receptor (rhodopsin family) EF-hand_6 PF13405.4 NM_010859.2_2 - 1.6e-08 33.6 0.1 0.0069 16.1 0.0 3.6 3 1 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 NM_010859.2_2 - 1.9e-05 23.7 1.4 0.037 13.4 0.0 4.0 4 0 0 4 4 4 1 EF hand EF-hand_7 PF13499.4 NM_010859.2_2 - 0.003 17.9 0.2 0.014 15.7 0.0 2.1 2 1 1 3 3 3 1 EF-hand domain pair Cas9_REC PF16592.3 NM_010859.2_2 - 0.083 11.5 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 DED PF01335.19 NM_010859.2_2 - 0.13 12.5 0.4 6.7 6.9 0.0 2.6 2 1 0 2 2 2 0 Death effector domain ENT PF03735.12 NM_172280.2_1 - 4.6e-27 93.8 1.7 9.1e-27 92.8 1.7 1.5 1 0 0 1 1 1 1 ENT domain RhlB PF12300.6 NM_172280.2_1 - 0.0002 21.5 0.6 0.0002 21.5 0.6 2.8 3 0 0 3 3 3 1 ATP-dependent RNA helicase RhlB Proteasome PF00227.24 NM_001310583.1_1 - 1.3e-53 181.2 0.2 1.5e-53 180.9 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Connexin PF00029.17 NM_001001496.2_1 - 4.4e-87 291.4 7.3 4.4e-87 291.4 7.3 1.8 2 0 0 2 2 2 1 Connexin DUF912 PF06024.10 NM_001001496.2_1 - 2 8.6 4.3 5.7 7.2 0.0 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) AMP-binding PF00501.26 NM_001177978.1_1 - 1.1e-67 228.3 0.0 1.5e-67 227.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 NM_001177978.1_1 - 4.7e-21 75.4 0.6 7.7e-21 74.7 0.6 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain V1R PF03402.12 NM_001166756.1_1 - 2.3e-15 56.8 13.0 3.3e-15 56.3 13.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001166756.1_1 - 1.1e-14 54.1 15.6 1.6e-14 53.6 15.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001166756.1_1 - 2.6e-06 26.7 13.9 3.5e-06 26.3 13.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Peptidase_M7 PF02031.14 NM_001166756.1_1 - 0.021 14.8 0.0 0.034 14.1 0.0 1.3 1 0 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family Anoctamin PF04547.10 NM_001166756.1_1 - 0.096 11.3 6.2 0.037 12.7 3.7 1.5 1 1 0 1 1 1 0 Calcium-activated chloride channel PRP8_domainIV PF12134.6 NM_001166756.1_1 - 0.098 12.2 0.1 0.57 9.7 0.0 2.0 2 0 0 2 2 2 0 PRP8 domain IV core DUF1700 PF08006.9 NM_001166756.1_1 - 0.34 10.3 6.4 0.28 10.6 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Fer4_4 PF12800.5 NM_001166756.1_3 - 0.53 10.8 0.1 0.53 10.8 0.1 4.9 5 0 0 5 5 5 0 4Fe-4S binding domain Perilipin PF03036.14 NM_025836.3_1 - 2.8e-163 543.5 19.6 4.3e-163 542.8 19.6 1.3 1 0 0 1 1 1 1 Perilipin family Baculo_PEP_C PF04513.10 NM_025836.3_1 - 0.0072 16.2 4.3 0.84 9.5 0.0 3.1 3 0 0 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.16 NM_025836.3_1 - 0.078 12.8 17.7 9.3e+02 -0.5 17.7 2.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Nup54 PF13874.4 NM_025836.3_1 - 2.1 8.3 12.9 19 5.2 11.1 2.6 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 WXG100 PF06013.10 NM_025836.3_1 - 3 8.0 8.9 1.1 9.4 0.9 3.3 2 1 0 2 2 2 0 Proteins of 100 residues with WXG DUF1993 PF09351.8 NM_025836.3_1 - 4.6 7.2 10.6 1.7 8.6 0.6 3.7 2 2 0 3 3 3 0 Domain of unknown function (DUF1993) ApoLp-III PF07464.9 NM_025836.3_1 - 8.3 6.4 14.8 2 8.4 2.5 3.2 2 2 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Serpin PF00079.18 NM_177920.5_1 - 3.7e-105 352.1 0.7 4.4e-105 351.9 0.7 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SLD5_C PF16922.3 NM_024240.6_2 - 6.5e-18 64.5 0.1 1.3e-17 63.6 0.1 1.5 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.9 NM_024240.6_2 - 2.9e-06 27.6 1.2 5.6e-06 26.7 1.2 1.4 1 0 0 1 1 1 1 GINS complex protein GETHR PF05671.9 NM_144809.2_1 - 5.8e-09 35.0 21.4 43 3.5 0.0 11.1 11 0 0 11 11 11 11 GETHR pentapeptide repeat (5 copies) Herpes_TK_C PF08465.8 NM_144809.2_1 - 0.014 15.0 9.9 1.1e+02 2.5 0.0 8.6 11 0 0 11 11 11 0 Thymidine kinase from Herpesvirus C-terminal rve_3 PF13683.4 NM_144809.2_1 - 0.031 13.9 0.0 1.2e+02 2.4 0.0 4.8 4 1 1 5 5 5 0 Integrase core domain zf-H2C2_2 PF13465.4 NM_144809.2_2 - 2.4e-78 255.2 70.5 1.1e-06 28.7 0.3 13.8 14 0 0 14 14 13 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_144809.2_2 - 5.2e-70 228.1 94.3 1.1e-06 28.6 0.9 14.3 15 0 0 15 15 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_144809.2_2 - 1.9e-37 124.5 92.7 0.0036 17.9 0.4 14.3 15 0 0 15 15 13 13 C2H2-type zinc finger SSXRD PF09514.8 NM_144809.2_2 - 2.6e-17 62.0 2.2 5.1e-17 61.0 2.2 1.5 1 0 0 1 1 1 1 SSXRD motif zf-C2H2_11 PF16622.3 NM_144809.2_2 - 9.5e-17 60.3 54.6 0.19 11.4 1.1 12.6 12 0 0 12 12 12 11 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 NM_144809.2_2 - 4.4e-11 42.6 49.8 0.052 13.5 1.5 8.0 2 1 10 12 12 12 10 Zinc ribbon domain zf-C2H2_6 PF13912.4 NM_144809.2_2 - 5.4e-10 38.8 58.8 1.1 9.1 0.3 12.6 12 0 0 12 12 12 7 C2H2-type zinc finger zf-trcl PF13451.4 NM_144809.2_2 - 1e-08 34.8 37.7 20 5.0 0.1 12.1 12 0 0 12 12 12 0 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 NM_144809.2_2 - 1.7e-08 34.9 38.7 0.37 11.4 0.8 7.6 2 1 5 7 7 7 6 zinc-ribbon family KRAB PF01352.25 NM_144809.2_2 - 1.5e-07 30.9 0.0 3.1e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 KRAB box ADK_lid PF05191.12 NM_144809.2_2 - 2.1e-07 30.7 35.1 0.11 12.4 0.1 7.7 3 1 8 11 11 10 9 Adenylate kinase, active site lid zf-C2H2_jaz PF12171.6 NM_144809.2_2 - 5e-05 23.4 44.1 1.9 8.8 0.2 12.6 14 0 0 14 14 13 1 Zinc-finger double-stranded RNA-binding SET PF00856.26 NM_144809.2_2 - 5.2e-05 23.6 1.4 0.00011 22.6 0.1 1.9 2 1 0 2 2 2 1 SET domain PHD PF00628.27 NM_144809.2_2 - 0.00011 21.9 46.1 0.79 9.5 1.8 7.7 2 1 5 9 9 9 6 PHD-finger XPA_N PF01286.16 NM_144809.2_2 - 0.00015 21.6 31.3 78 3.3 0.0 12.1 13 0 0 13 13 12 0 XPA protein N-terminal DUF3268 PF11672.6 NM_144809.2_2 - 0.0018 18.5 38.7 3 8.1 1.1 7.8 1 1 10 11 11 11 6 zinc-finger-containing domain zf-met PF12874.5 NM_144809.2_2 - 1.7 9.0 69.1 6.2 7.2 0.7 12.5 13 0 0 13 13 12 0 Zinc-finger of C2H2 type PsaD PF02531.14 NM_144809.2_3 - 2.5e-07 30.2 31.6 20 4.5 0.1 10.9 11 0 0 11 11 11 11 PsaD Utp21 PF04192.10 NM_001110016.1_2 - 2.6e-60 203.7 1.1 3.8e-60 203.2 1.1 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.30 NM_001110016.1_2 - 4.7e-20 71.4 10.8 2.3e-08 34.4 0.2 8.9 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001110016.1_2 - 2e-11 43.9 0.0 0.00024 21.2 0.0 5.8 4 2 4 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_001110016.1_2 - 1.1e-05 24.7 0.0 0.031 13.5 0.0 3.1 2 1 1 3 3 3 2 WD40-like domain RnaseA PF00074.18 NM_007895.2_3 - 6.4e-33 113.7 5.8 8.6e-33 113.3 5.8 1.2 1 0 0 1 1 1 1 Pancreatic ribonuclease Nup160 PF11715.6 NM_021512.2_1 - 6.3e-129 430.9 0.0 8.2e-129 430.5 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_2 PF07719.15 NM_021512.2_1 - 0.075 13.1 0.1 0.63 10.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PCI PF01399.25 NM_011991.1_2 - 1.3e-19 70.5 1.1 4.3e-19 68.9 0.2 2.2 2 0 0 2 2 2 1 PCI domain RasGEF PF00617.17 NM_011991.1_2 - 0.006 16.7 0.3 0.46 10.5 0.1 2.9 3 0 0 3 3 3 1 RasGEF domain TPR_1 PF00515.26 NM_011991.1_2 - 0.013 15.2 2.7 0.021 14.5 0.9 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 NM_011991.1_2 - 0.092 12.8 2.2 0.2 11.7 0.9 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.10 NM_011991.1_2 - 0.094 13.3 1.0 0.22 12.1 1.0 1.7 1 0 0 1 1 1 0 Sel1 repeat TPR_8 PF13181.4 NM_011991.1_2 - 0.36 11.0 3.5 2 8.7 0.4 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 NM_011991.1_2 - 0.4 10.5 1.3 1.8 8.5 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat PRKCSH-like PF12999.5 NM_008925.2_3 - 5.5e-42 143.4 5.2 5.5e-42 143.4 5.2 2.2 2 1 1 3 3 3 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.4 NM_008925.2_3 - 3.7e-20 72.0 0.0 6.7e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.11 NM_008925.2_3 - 1.6e-10 41.7 0.5 7.4e-10 39.6 0.5 2.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein EF-hand_5 PF13202.4 NM_008925.2_3 - 1e-08 34.1 0.2 0.00076 18.8 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.30 NM_008925.2_3 - 6e-06 25.3 0.0 0.15 11.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_008925.2_3 - 2.1e-05 24.0 0.1 0.25 11.2 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain Ldl_recept_a PF00057.16 NM_008925.2_3 - 0.00022 21.3 9.5 0.03 14.4 2.8 2.6 1 1 1 2 2 2 2 Low-density lipoprotein receptor domain class A EF-hand_7 PF13499.4 NM_008925.2_3 - 0.00055 20.2 0.2 1.3 9.4 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 NM_008925.2_3 - 0.0047 16.5 0.2 1.8 8.3 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair DUF3450 PF11932.6 NM_008925.2_3 - 0.4 9.8 14.6 2.4 7.2 8.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Sec34 PF04136.13 NM_008925.2_3 - 3 7.6 5.8 20 4.9 0.1 2.2 2 0 0 2 2 2 0 Sec34-like family 7tm_4 PF13853.4 NM_001011868.1_1 - 6.9e-49 166.9 18.8 8.7e-49 166.6 18.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011868.1_1 - 8.5e-20 71.0 18.7 2.1e-19 69.7 18.7 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_001011868.1_1 - 0.99 8.9 2.9 3.7 7.0 2.9 2.0 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus RabGAP-TBC PF00566.16 NM_001285993.1_3 - 1.8e-24 86.5 12.5 1.8e-24 86.5 12.5 3.4 2 1 0 2 2 2 1 Rab-GTPase-TBC domain TFIIA PF03153.11 NM_001285993.1_3 - 0.0012 18.8 16.4 0.0019 18.2 16.4 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF3452 PF11934.6 NM_001285993.1_3 - 0.045 13.2 0.1 0.045 13.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) Spt20 PF12090.6 NM_001285993.1_3 - 0.31 10.5 27.5 0.54 9.7 27.5 1.3 1 0 0 1 1 1 0 Spt20 family eIF-3_zeta PF05091.10 NM_001285993.1_3 - 0.37 9.6 6.0 0.58 8.9 6.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PAT1 PF09770.7 NM_001285993.1_3 - 0.47 8.5 17.3 0.66 8.0 17.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.14 NM_001285993.1_3 - 0.57 10.1 2.7 1.1 9.1 2.7 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Apt1 PF10351.7 NM_001285993.1_3 - 0.7 8.6 12.0 1.2 7.8 12.0 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Suf PF05843.12 NM_001285993.1_3 - 1.3 8.8 8.2 2.2 8.0 8.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) 7tm_1 PF00001.19 NM_010101.4_1 - 1.7e-35 122.4 21.2 1.7e-35 122.4 21.2 2.7 3 0 0 3 3 3 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_010101.4_1 - 6.2e-09 35.5 21.0 6.2e-09 35.5 21.0 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_010101.4_1 - 0.0013 18.4 16.1 0.078 12.6 1.6 2.6 2 0 0 2 2 2 2 Olfactory receptor GLTP PF08718.9 NM_001164361.1_1 - 4.9e-42 143.6 0.0 8.7e-42 142.8 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) PH PF00169.27 NM_001164361.1_1 - 5.6e-11 42.7 0.0 1.2e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 NM_001164361.1_1 - 0.00059 19.9 0.0 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 NM_001164361.1_1 - 0.0017 18.6 0.1 0.0049 17.1 0.1 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain FAM178 PF14816.4 NM_201365.2_2 - 5.4e-117 390.8 9.6 6.6e-116 387.2 7.6 2.1 1 1 1 2 2 2 2 Family of unknown function, FAM178 Ephrin PF00812.15 NM_001162425.1_2 - 5.2e-35 120.3 2.6 7.7e-35 119.8 2.6 1.2 1 0 0 1 1 1 1 Ephrin Ras PF00071.20 NM_001128090.1_3 - 1e-27 96.6 0.0 1.2e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001128090.1_3 - 1.5e-05 25.1 0.0 2.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF220 PF02713.12 NM_001128090.1_3 - 0.089 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF220 SNF5 PF04855.10 NM_001128090.1_3 - 0.13 11.8 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 SNF5 / SMARCB1 / INI1 Peptidase_M1 PF01433.18 NM_145417.3_2 - 6.2e-82 275.8 0.0 8.2e-82 275.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.9 NM_145417.3_2 - 2.1e-37 128.1 0.3 3.2e-37 127.6 0.3 1.3 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.4 NM_145417.3_2 - 0.037 13.6 0.1 0.1 12.1 0.0 1.7 2 0 0 2 2 2 0 Peptidase MA superfamily BTB PF00651.29 NM_001163730.2_1 - 7.1e-28 96.9 0.1 1.5e-27 95.9 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 NM_001163730.2_1 - 0.018 15.0 0.1 0.088 12.8 0.1 2.1 2 0 0 2 2 2 0 BTB And C-terminal Kelch p450 PF00067.20 NM_021282.2_2 - 3.9e-146 487.3 0.0 4.5e-146 487.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SNARE_assoc PF09335.9 NM_153525.5_2 - 5.4e-21 75.2 9.4 5.7e-21 75.1 6.2 2.4 2 0 0 2 2 2 1 SNARE associated Golgi protein HLH PF00010.24 NM_001083967.1_3 - 1.6e-11 43.9 1.0 5.1e-11 42.2 1.0 2.0 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 NM_001083967.1_3 - 3.4 5.7 6.9 7.1 4.7 6.9 1.4 1 0 0 1 1 1 0 CDC45-like protein HSR PF03172.11 NM_175219.3_2 - 7.8e-38 128.5 3.3 1.2e-37 127.9 3.3 1.3 1 0 0 1 1 1 1 HSR domain Lbh PF15317.4 NM_175219.3_2 - 0.0065 17.2 0.4 0.0065 17.2 0.4 2.3 2 1 1 3 3 3 1 Cardiac transcription factor regulator, Developmental protein Fer2_BFD PF04324.13 NM_175219.3_2 - 0.024 14.9 0.2 0.054 13.7 0.2 1.6 1 0 0 1 1 1 0 BFD-like [2Fe-2S] binding domain V-set PF07686.15 NM_080419.2_2 - 1.8e-24 85.8 0.0 8.2e-08 32.2 0.0 5.1 4 2 0 4 4 4 4 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_080419.2_2 - 1.5e-17 63.8 0.0 0.0017 18.8 0.0 5.9 5 3 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 NM_080419.2_2 - 1.5e-14 53.7 0.0 0.014 15.3 0.0 6.2 6 1 0 6 6 6 4 Immunoglobulin I-set domain ig PF00047.23 NM_080419.2_2 - 4.9e-09 36.1 0.1 0.11 12.5 0.0 6.4 6 2 0 6 6 6 1 Immunoglobulin domain Ig_2 PF13895.4 NM_080419.2_2 - 2e-07 31.1 2.5 2.7 8.3 0.1 6.8 7 2 1 8 8 8 2 Immunoglobulin domain Izumo-Ig PF16706.3 NM_080419.2_2 - 0.002 18.0 0.1 6.5 6.7 0.0 4.3 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain Ion_trans PF00520.29 NM_001159535.2_2 - 3.8e-254 838.3 91.0 6.7e-71 238.2 18.1 5.2 6 0 0 6 6 6 4 Ion transport protein CAC1F_C PF16885.3 NM_001159535.2_2 - 3.2e-37 128.9 3.9 3.2e-37 128.9 3.9 2.7 2 1 0 2 2 2 1 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 NM_001159535.2_2 - 5.7e-36 122.0 0.0 1.2e-35 120.9 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 NM_001159535.2_2 - 5.7e-30 103.3 0.1 1.1e-29 102.3 0.1 1.5 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 NM_001159535.2_2 - 7e-09 34.7 78.2 2.2e-07 29.8 9.2 7.8 7 1 0 7 7 7 3 Polycystin cation channel Etmic-2 PF06670.9 NM_001159535.2_2 - 0.0087 14.9 1.0 0.014 14.2 1.0 1.2 1 0 0 1 1 1 1 Microneme protein Etmic-2 TBD PF12845.5 NM_001164072.1_3 - 2.8e-25 87.9 0.3 5.9e-25 86.8 0.3 1.6 1 0 0 1 1 1 1 TBD domain DUF5082 PF16888.3 NM_001164072.1_3 - 0.0084 16.3 1.1 0.017 15.3 1.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) OEP PF02321.16 NM_001164072.1_3 - 0.59 9.8 6.4 0.89 9.2 6.4 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein Jnk-SapK_ap_N PF09744.7 NM_001164072.1_3 - 3.8 7.6 9.6 1.9 8.5 2.7 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 IncA PF04156.12 NM_001164072.1_3 - 7.1 6.2 10.2 6.6 6.3 8.8 1.5 1 1 0 1 1 1 0 IncA protein Glyco_transf_29 PF00777.16 NM_016973.3_1 - 7.2e-34 117.2 0.0 1e-33 116.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) SPAR_C PF11881.6 NM_001081028.1_2 - 4.3e-94 314.8 4.8 1e-93 313.5 4.8 1.7 1 0 0 1 1 1 1 C-terminal domain of SPAR protein Rap_GAP PF02145.13 NM_001081028.1_2 - 1e-66 224.0 0.1 1.6e-66 223.3 0.1 1.3 1 0 0 1 1 1 1 Rap/ran-GAP PDZ PF00595.22 NM_001081028.1_2 - 0.0003 21.0 0.0 0.00051 20.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) CCDC168_N PF15804.3 NM_001081028.1_2 - 0.0073 16.1 1.6 0.015 15.0 1.6 1.5 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 168 IncA PF04156.12 NM_001081028.1_2 - 0.025 14.2 4.2 0.044 13.4 4.2 1.3 1 0 0 1 1 1 0 IncA protein HAUS-augmin3 PF14932.4 NM_001081028.1_2 - 0.62 9.4 5.3 0.98 8.8 5.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 CENP-K PF11802.6 NM_001081028.1_2 - 0.74 9.2 7.1 1.6 8.1 7.1 1.5 1 0 0 1 1 1 0 Centromere-associated protein K TMF_TATA_bd PF12325.6 NM_001081028.1_2 - 0.8 9.8 6.6 1.5 8.9 6.6 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.13 NM_001081028.1_2 - 6 6.6 5.1 12 5.6 5.1 1.4 1 0 0 1 1 1 0 Septum formation initiator Lipocalin PF00061.21 NM_008647.4_2 - 2.9e-31 108.5 0.1 3.6e-31 108.2 0.1 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family ELH PF02323.13 NM_008647.4_2 - 0.054 12.7 0.0 0.079 12.2 0.0 1.2 1 0 0 1 1 1 0 Egg-laying hormone precursor CEP63 PF17045.3 NM_181816.2_1 - 2.2e-88 296.6 39.4 2.2e-88 296.6 39.4 2.7 3 1 0 3 3 3 1 Centrosomal protein of 63 kDa DASH_Dad2 PF08654.8 NM_181816.2_1 - 0.075 13.3 10.5 0.098 13.0 0.9 3.3 2 1 0 2 2 2 0 DASH complex subunit Dad2 HALZ PF02183.16 NM_181816.2_1 - 0.078 13.1 16.9 1.2 9.3 0.1 4.5 4 0 0 4 4 4 0 Homeobox associated leucine zipper OCIA PF07051.9 NM_023429.4_3 - 4.5e-35 119.4 0.1 7.9e-35 118.6 0.1 1.4 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) AIG1 PF04548.14 NM_001270430.1_2 - 1.3e-28 99.7 0.0 1.8e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.21 NM_001270430.1_2 - 2.8e-06 27.2 0.0 1.1e-05 25.4 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.16 NM_001270430.1_2 - 0.00021 20.6 0.3 0.00068 18.9 0.0 1.9 2 0 0 2 2 2 1 FtsK/SpoIIIE family Dynamin_N PF00350.21 NM_001270430.1_2 - 0.019 14.9 0.2 0.34 10.8 0.2 2.3 2 0 0 2 2 2 0 Dynamin family GEP5 PF17053.3 NM_001270430.1_2 - 0.037 13.8 0.0 0.046 13.4 0.0 1.2 1 0 0 1 1 1 0 Genetic interactor of prohibitin 5 Ig_3 PF13927.4 NM_026103.1_2 - 5.2e-12 46.1 0.1 8.3e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_026103.1_2 - 1e-09 38.4 0.0 7.9e-07 29.1 0.0 3.0 2 1 1 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.14 NM_026103.1_2 - 5.5e-09 35.8 0.0 0.00029 20.7 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 NM_026103.1_2 - 1.7e-07 31.2 0.0 0.0018 18.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_026103.1_2 - 6.1e-06 26.4 0.2 0.00058 20.0 0.2 2.4 2 0 0 2 2 2 1 Immunoglobulin domain NESP55 PF06390.10 NM_026103.1_2 - 0.0091 15.5 8.1 0.015 14.7 8.1 1.3 1 0 0 1 1 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) Gly-zipper_Omp PF13488.4 NM_026103.1_2 - 0.017 15.0 0.9 0.032 14.1 0.9 1.3 1 0 0 1 1 1 0 Glycine zipper Gly-zipper_YMGG PF13441.4 NM_026103.1_2 - 0.028 14.0 0.1 0.053 13.1 0.1 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper Trypan_PARP PF05887.9 NM_026103.1_2 - 0.033 14.1 45.0 0.19 11.6 44.9 2.0 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Rick_17kDa_Anti PF05433.13 NM_026103.1_2 - 0.041 13.6 1.2 0.075 12.8 1.2 1.3 1 0 0 1 1 1 0 Glycine zipper 2TM domain Ax_dynein_light PF10211.7 NM_175223.4_3 - 2.1e-92 308.1 16.1 2.6e-92 307.8 16.1 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain RIB43A PF05914.10 NM_175223.4_3 - 0.027 13.1 11.8 0.038 12.6 11.8 1.2 1 0 0 1 1 1 0 RIB43A APG6 PF04111.10 NM_175223.4_3 - 0.052 12.8 8.9 0.072 12.3 8.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 PRKG1_interact PF15898.3 NM_175223.4_3 - 0.17 12.7 12.4 0.4 11.5 12.4 1.6 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF3373 PF11853.6 NM_175223.4_3 - 1.1 7.8 3.1 1.6 7.3 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Jnk-SapK_ap_N PF09744.7 NM_175223.4_3 - 3.4 7.7 18.8 0.76 9.9 14.6 1.9 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Mnd1 PF03962.13 NM_175223.4_3 - 4.4 7.0 14.6 7.8 6.2 14.6 1.3 1 0 0 1 1 1 0 Mnd1 family ADIP PF11559.6 NM_175223.4_3 - 5.4 7.0 15.3 9.4 6.2 15.3 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TSNAXIP1_N PF15739.3 NM_175223.4_3 - 6.8 7.0 15.5 1.4 9.2 5.1 2.3 1 1 1 2 2 2 0 Translin-associated factor X-interacting N-terminus DUF724 PF05266.12 NM_175223.4_3 - 8 6.1 11.8 6.1 6.5 9.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Mto2_bdg PF12808.5 NM_175223.4_3 - 9.7 6.4 14.4 2.9 8.1 4.1 2.5 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Annexin PF00191.18 NM_001110794.1_1 - 9.2e-98 320.2 8.0 3.4e-26 91.0 0.4 4.2 4 0 0 4 4 4 4 Annexin V-set PF07686.15 NM_029612.4_3 - 1.3e-10 41.3 0.1 9.3e-10 38.5 0.0 2.2 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_029612.4_3 - 9.6e-09 35.6 2.6 0.00043 20.7 1.7 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_029612.4_3 - 2.1e-06 27.7 0.5 0.024 14.7 0.4 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_029612.4_3 - 9.7e-06 25.7 3.3 0.011 15.9 0.8 2.5 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_029612.4_3 - 0.0001 22.2 0.1 0.0021 18.0 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin I-set domain Syndecan PF01034.18 NM_029612.4_3 - 0.046 13.5 0.1 0.095 12.5 0.1 1.5 1 0 0 1 1 1 0 Syndecan domain DUF2810 PF10928.6 NM_011014.3_1 - 0.056 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2810) ERG2_Sigma1R PF04622.10 NM_011014.3_3 - 1.6e-64 216.9 0.4 2.5e-64 216.4 0.4 1.2 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein TRP_2 PF08344.9 NM_011643.3_1 - 1.1e-24 86.3 2.2 2.2e-24 85.3 2.2 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ion_trans PF00520.29 NM_011643.3_1 - 2.8e-16 59.4 13.6 5.1e-16 58.5 13.6 1.4 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.5 NM_011643.3_1 - 1.7e-05 25.2 1.1 0.00068 20.0 0.2 2.6 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_011643.3_1 - 0.00052 20.4 0.1 1.3 9.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ldh_1_N PF00056.21 NM_013580.4_2 - 3e-46 156.9 0.7 4.2e-46 156.4 0.7 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 NM_013580.4_2 - 1.6e-23 83.3 0.0 2.6e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain ThiF PF00899.19 NM_013580.4_2 - 0.008 15.4 0.2 0.015 14.6 0.2 1.3 1 0 0 1 1 1 1 ThiF family Glyco_hydro_4 PF02056.14 NM_013580.4_2 - 0.065 12.7 0.2 0.4 10.1 0.0 2.0 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase Pyr_redox_2 PF07992.12 NM_013580.4_2 - 0.09 11.9 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.12 NM_013580.4_2 - 0.091 12.2 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain zf-RING_UBOX PF13445.4 NM_001220499.2_3 - 5.1e-08 32.7 0.4 5.1e-08 32.7 0.4 2.4 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_001220499.2_3 - 8.2e-08 32.3 4.2 8.2e-08 32.3 4.2 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 NM_001220499.2_3 - 4.7e-06 26.3 4.5 4.7e-06 26.3 4.5 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 NM_001220499.2_3 - 4.8e-06 26.2 3.0 1.4e-05 24.7 3.0 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001220499.2_3 - 6.5e-06 25.8 3.6 1.8e-05 24.4 3.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_001220499.2_3 - 0.00082 19.3 5.8 0.0028 17.6 5.8 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 NM_001220499.2_3 - 0.0028 17.3 3.3 0.01 15.5 3.3 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.4 NM_001220499.2_3 - 0.85 9.3 4.3 2.3 7.9 4.3 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.4 NM_001220499.2_3 - 3.1 7.6 11.1 0.17 11.7 4.8 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.3 NM_001220499.2_3 - 5.6 6.6 14.0 0.23 11.1 5.5 2.7 2 0 0 2 2 2 0 RING-like zinc finger IL8 PF00048.18 NM_009138.3_2 - 3.6e-15 55.7 0.3 7.2e-15 54.8 0.3 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like CiPC PF15800.3 NM_001289432.1_2 - 5.9e-96 322.0 15.3 7.6e-96 321.7 15.3 1.1 1 0 0 1 1 1 1 Clock interacting protein circadian PID_2 PF14719.4 NM_001003948.2_3 - 2.3e-17 63.3 0.2 3.7e-17 62.6 0.2 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) MA3 PF02847.15 NM_011050.4_3 - 8.5e-48 160.9 2.0 4e-25 87.9 0.6 3.0 3 0 0 3 3 3 2 MA3 domain HABP4_PAI-RBP1 PF04774.13 NM_011050.4_3 - 0.016 15.9 2.1 0.036 14.8 0.0 2.1 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family PCI PF01399.25 NM_011050.4_3 - 0.15 12.4 0.0 0.57 10.6 0.0 1.9 1 0 0 1 1 1 0 PCI domain Cyclin_N PF00134.21 NM_001081636.1_1 - 4.7e-34 116.8 0.9 6.5e-34 116.3 0.9 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 NM_001081636.1_1 - 7.2e-17 61.4 0.1 1.8e-16 60.1 0.0 1.7 2 0 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.8 NM_001081636.1_1 - 0.018 15.3 0.3 0.031 14.5 0.3 1.4 1 0 0 1 1 1 0 K cyclin, C terminal Pes-10 PF07149.9 NM_001244654.1_2 - 0.0059 15.6 1.0 13 4.6 0.1 4.3 3 2 2 5 5 5 2 Pes-10 DUF853 PF05872.10 NM_001244654.1_2 - 0.0089 14.5 4.2 1.1e+02 1.0 0.0 8.8 9 1 1 10 10 10 0 Bacterial protein of unknown function (DUF853) Epiglycanin_C PF14654.4 NM_001244654.1_3 - 9.8e-19 67.2 0.0 2.3e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Mucin, catalytic, TM and cytoplasmic tail region PXA PF02194.13 NM_207213.2_1 - 5.8e-28 97.7 6.3 2.8e-27 95.5 2.3 3.0 2 1 0 2 2 2 1 PXA domain Nexin_C PF08628.10 NM_207213.2_1 - 2.6e-26 92.2 2.3 7.3e-26 90.8 1.0 2.6 2 0 0 2 2 2 1 Sorting nexin C terminal RGS PF00615.17 NM_207213.2_1 - 4.5e-19 68.7 2.0 1e-18 67.6 1.2 2.2 2 0 0 2 2 2 1 Regulator of G protein signaling domain PX PF00787.22 NM_207213.2_1 - 4.7e-17 61.9 0.1 4.7e-17 61.9 0.1 2.2 3 0 0 3 3 3 1 PX domain VirE PF05272.9 NM_207213.2_1 - 0.0093 15.6 0.1 2.2 7.8 0.1 2.5 2 0 0 2 2 2 2 Virulence-associated protein E Isy1 PF06246.10 NM_207213.2_1 - 0.012 15.1 0.2 0.012 15.1 0.2 2.0 2 0 0 2 2 2 0 Isy1-like splicing family Macro PF01661.19 NM_207219.4_1 - 7.5e-06 25.9 0.0 1.3e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Macro domain PSII_Pbs27 PF13326.4 NM_207219.4_1 - 0.15 12.2 0.0 0.24 11.6 0.0 1.2 1 0 0 1 1 1 0 Photosystem II Pbs27 Ig_3 PF13927.4 NM_001122680.1_1 - 2.3e-20 72.9 0.1 6.9e-08 32.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_001122680.1_1 - 8.1e-19 67.7 0.0 7e-15 55.0 0.0 3.2 4 0 0 4 4 4 2 Immunoglobulin V-set domain ig PF00047.23 NM_001122680.1_1 - 2.4e-17 62.7 0.0 2.7e-05 24.1 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.10 NM_001122680.1_1 - 1.8e-16 59.9 1.0 8.9e-15 54.4 0.2 2.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 NM_001122680.1_1 - 1.6e-15 56.8 0.0 8.4e-05 22.4 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001122680.1_1 - 7.2e-12 45.4 0.1 4.1e-05 23.7 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin domain Protocadherin PF08374.9 NM_001122680.1_1 - 0.0028 17.5 0.0 0.0047 16.8 0.0 1.2 1 0 0 1 1 1 1 Protocadherin DUF1191 PF06697.10 NM_001122680.1_1 - 0.01 15.0 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) TMEM154 PF15102.4 NM_001122680.1_1 - 0.036 13.8 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.4 NM_001122680.1_1 - 0.049 14.3 0.1 0.049 14.3 0.1 2.9 3 0 0 3 3 1 0 Ephrin type-A receptor 2 transmembrane domain ABC_membrane_3 PF13748.4 NM_001122680.1_1 - 0.06 12.5 0.4 0.095 11.8 0.4 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region Ctr PF04145.13 NM_001122680.1_1 - 0.092 13.2 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Ctr copper transporter family Chordopox_A13L PF05961.9 NM_001122680.1_1 - 0.094 12.8 0.0 0.094 12.8 0.0 2.2 2 0 0 2 2 1 0 Chordopoxvirus A13L protein Glycos_transf_2 PF00535.24 NM_134189.2_1 - 4.1e-35 120.9 0.0 6e-35 120.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 NM_134189.2_1 - 1e-26 93.6 1.2 1.6e-26 92.9 1.2 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 NM_134189.2_1 - 2.2e-05 23.9 0.2 4.4e-05 22.9 0.2 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 NM_134189.2_1 - 0.0072 15.7 0.0 0.013 14.8 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 STAT_bind PF02864.13 NM_019963.1_2 - 3.1e-64 217.1 0.1 7.5e-64 215.9 0.0 1.7 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 NM_019963.1_2 - 2.5e-45 154.4 8.3 2.5e-45 154.4 8.3 1.9 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 NM_019963.1_2 - 6.8e-28 97.5 5.2 6.8e-28 97.5 5.2 2.4 2 0 0 2 2 2 1 STAT protein, protein interaction domain STAT2_C PF12188.6 NM_019963.1_2 - 3.8e-23 81.1 2.6 4.8e-23 80.7 1.4 1.8 2 0 0 2 2 2 1 Signal transducer and activator of transcription 2 C terminal SH2 PF00017.22 NM_019963.1_2 - 9.6e-11 41.5 0.3 3.8e-10 39.6 0.0 2.1 2 0 0 2 2 2 1 SH2 domain RAP PF08373.8 NM_019963.1_2 - 9.4 6.3 6.3 1.9 8.5 1.1 2.4 2 0 0 2 2 2 0 RAP domain SAICAR_synt PF01259.16 NM_025939.2_2 - 9.1e-56 189.1 0.0 1.2e-55 188.7 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase AIRC PF00731.18 NM_025939.2_2 - 1.5e-37 128.3 0.0 2.5e-37 127.6 0.0 1.3 1 0 0 1 1 1 1 AIR carboxylase BAR PF03114.16 NM_001277955.1_2 - 4.7e-30 104.9 5.4 6.3e-30 104.4 5.4 1.1 1 0 0 1 1 1 1 BAR domain SH3_2 PF07653.15 NM_001277955.1_2 - 4.7e-13 48.5 0.2 1.4e-12 46.9 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 NM_001277955.1_2 - 7.1e-13 47.8 0.2 1.6e-12 46.7 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 NM_001277955.1_2 - 3.6e-12 45.8 0.2 7e-12 44.9 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.7 NM_001277955.1_2 - 0.024 13.6 2.4 0.033 13.2 2.4 1.1 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF310 PF03750.11 NM_001277955.1_2 - 0.062 14.0 0.5 0.12 13.1 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF310) BAR PF03114.16 NM_001277955.1_3 - 1e-17 64.5 0.2 1.2e-17 64.2 0.2 1.1 1 0 0 1 1 1 1 BAR domain Tub PF01167.16 NM_001290998.2_3 - 3.7e-83 278.4 0.0 4.7e-83 278.0 0.0 1.1 1 0 0 1 1 1 1 Tub family Reprolysin_5 PF13688.4 NM_001277266.1_3 - 1.1e-31 110.4 0.0 2.2e-31 109.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.4 NM_001277266.1_3 - 7.4e-31 107.4 0.0 1.3e-30 106.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM17_MPD PF16698.3 NM_001277266.1_3 - 9.4e-20 70.6 15.7 9.4e-20 70.6 15.7 3.6 2 1 1 3 3 3 1 Membrane-proximal domain, switch, for ADAM17 Disintegrin PF00200.21 NM_001277266.1_3 - 5.9e-15 55.7 23.9 5.9e-15 55.7 23.9 3.4 3 0 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.4 NM_001277266.1_3 - 3.5e-12 46.8 0.0 7.3e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.17 NM_001277266.1_3 - 1.2e-08 35.0 0.1 2.2e-06 27.6 0.2 3.0 2 1 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 NM_001277266.1_3 - 1.9e-07 31.3 0.0 3.9e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_4 PF13583.4 NM_001277266.1_3 - 1.3e-05 24.8 0.1 2.1e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like 7tm_4 PF13853.4 NM_146722.2_2 - 3.6e-65 220.3 16.2 4.4e-65 220.1 16.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146722.2_2 - 1.8e-23 83.0 15.3 4e-23 81.9 15.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1151 PF06625.9 NM_183187.3_1 - 6.4e-38 129.1 16.7 9.2e-38 128.6 16.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1151) KIAA1328 PF15369.4 NM_183187.3_1 - 0.76 9.4 10.1 1.1 8.8 10.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Hormone_recep PF00104.28 NM_013920.2_3 - 2.5e-40 138.2 0.3 3.8e-40 137.5 0.3 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_013920.2_3 - 4.4e-28 97.4 20.5 4.4e-28 97.4 20.5 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) DUF3246 PF11596.6 NM_023129.5_1 - 0.11 11.7 3.0 0.16 11.2 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Phospholamban PF04272.12 NM_023129.5_2 - 6.6e-34 115.0 10.4 6.6e-34 115.0 10.4 2.6 2 0 0 2 2 2 1 Phospholamban Sarcolipin PF05366.9 NM_023129.5_2 - 0.39 10.3 4.8 1.5 8.5 4.8 2.0 1 0 0 1 1 1 0 Sarcolipin Pkinase PF00069.23 NM_001199352.1_1 - 2.2e-75 253.3 0.0 2.7e-75 253.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001199352.1_1 - 8.9e-35 120.1 0.0 1.1e-34 119.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001199352.1_1 - 2.4e-06 26.9 0.0 3.4e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001199352.1_1 - 0.0014 17.9 0.0 0.0024 17.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001199352.1_1 - 0.064 13.0 0.0 1.4 8.7 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.20 NM_001199352.1_1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 RIO1 family DALR_1 PF05746.13 NM_026378.3_2 - 3.4e-22 78.7 0.0 5.4e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 DALR anticodon binding domain DUF1180 PF06679.10 NM_027207.2_2 - 1.4e-08 35.2 1.5 4.2e-08 33.7 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1180) DUF378 PF04070.10 NM_027207.2_2 - 0.036 13.8 0.2 0.055 13.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF378) Gly_acyl_tr_N PF06021.9 NM_145935.3_2 - 3.3e-87 291.7 3.0 4.5e-87 291.2 3.0 1.2 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.8 NM_145935.3_2 - 3.4e-43 145.7 1.9 8.4e-43 144.4 1.9 1.7 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region FR47 PF08445.8 NM_145935.3_2 - 0.11 12.4 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein YtxH PF12732.5 NM_001286546.1_1 - 0.011 16.1 5.1 0.068 13.6 4.8 2.5 2 0 0 2 2 2 0 YtxH-like protein DUF4366 PF14283.4 NM_001286546.1_1 - 0.017 14.5 0.0 0.017 14.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) PLAC8 PF04749.15 NM_027072.1_2 - 2.1e-11 44.5 13.4 3.9e-11 43.7 13.4 1.5 1 0 0 1 1 1 1 PLAC8 family gag-asp_proteas PF13975.4 NM_199468.1_2 - 0.0048 17.3 0.0 0.016 15.6 0.0 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.9 NM_199468.1_2 - 0.096 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.4 NM_199468.1_2 - 0.099 13.2 0.0 0.22 12.1 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease DUF4939 PF16297.3 NM_199468.1_3 - 1e-06 28.4 0.0 2.1e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 NM_199468.1_3 - 2e-05 24.6 0.0 4.5e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.21 NM_199468.1_3 - 0.00025 20.8 1.2 0.00055 19.8 1.2 1.6 1 0 0 1 1 1 1 Zinc knuckle SSXT PF05030.10 NM_199468.1_3 - 0.014 14.9 0.3 0.031 13.8 0.3 1.5 1 0 0 1 1 1 0 SSXT protein (N-terminal region) zf-CCHC_2 PF13696.4 NM_199468.1_3 - 0.068 12.9 3.5 0.14 11.9 3.5 1.5 1 0 0 1 1 1 0 Zinc knuckle V-set PF07686.15 NM_030181.3_2 - 5.3e-17 61.8 0.1 3.3e-14 52.8 0.0 3.0 2 1 1 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_030181.3_2 - 3.9e-16 59.3 0.3 9.3e-08 32.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_030181.3_2 - 4.6e-11 42.5 0.0 0.00032 20.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 NM_030181.3_2 - 1.3e-09 37.9 0.0 1.9e-05 24.6 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_030181.3_2 - 1.7e-08 34.5 0.5 0.00065 19.9 0.2 2.8 2 1 0 2 2 2 2 Immunoglobulin domain NESP55 PF06390.10 NM_030181.3_2 - 0.01 15.3 8.2 0.018 14.6 8.2 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Gly-zipper_Omp PF13488.4 NM_030181.3_2 - 0.019 14.8 0.9 0.036 14.0 0.9 1.3 1 0 0 1 1 1 0 Glycine zipper Trypan_PARP PF05887.9 NM_030181.3_2 - 0.029 14.3 44.5 0.16 11.9 44.5 1.9 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Gly-zipper_YMGG PF13441.4 NM_030181.3_2 - 0.032 13.8 0.1 0.059 13.0 0.1 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.13 NM_030181.3_2 - 0.046 13.5 1.2 0.083 12.7 1.2 1.3 1 0 0 1 1 1 0 Glycine zipper 2TM domain Pkinase PF00069.23 NM_153785.4_3 - 9.2e-74 248.0 0.0 1.3e-73 247.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_153785.4_3 - 1.8e-37 128.9 0.0 5.9e-37 127.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_153785.4_3 - 1.6e-06 27.5 0.0 2.7e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 NM_153785.4_3 - 0.00024 20.6 0.1 0.00043 19.8 0.1 1.3 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.4 NM_153785.4_3 - 0.00057 19.4 0.4 0.22 11.0 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 NM_153785.4_3 - 0.00075 18.8 0.4 0.0014 17.9 0.4 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MdcG PF10620.7 NM_153785.4_3 - 0.013 15.1 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl-dephospho-CoA transferase MdcG APH PF01636.21 NM_153785.4_3 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PX PF00787.22 NM_029721.2_3 - 1.9e-18 66.4 0.1 3.7e-18 65.4 0.1 1.5 1 0 0 1 1 1 1 PX domain PDZ PF00595.22 NM_029721.2_3 - 1.3e-14 54.1 0.4 2.1e-14 53.5 0.4 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RA PF00788.21 NM_029721.2_3 - 8.7e-11 42.2 0.0 1.7e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ_2 PF13180.4 NM_029721.2_3 - 0.00028 21.0 0.6 0.0016 18.6 0.0 2.1 2 0 0 2 2 2 1 PDZ domain USP7_C2 PF14533.4 NM_029721.2_3 - 0.0036 16.9 0.0 0.0057 16.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal SSrecog PF03531.12 NM_029721.2_3 - 0.01 15.1 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) UBX PF00789.18 NM_029721.2_3 - 0.061 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 UBX domain FERM_N PF09379.8 NM_029721.2_3 - 0.083 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 FERM N-terminal domain RBD PF02196.13 NM_029721.2_3 - 0.15 12.1 0.0 0.42 10.6 0.0 1.7 1 0 0 1 1 1 0 Raf-like Ras-binding domain CTNNBL PF08216.9 NM_025680.4_1 - 7.6e-41 138.4 0.8 1.5e-40 137.4 0.8 1.6 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.21 NM_025680.4_1 - 0.24 11.4 5.0 9.9 6.2 0.1 3.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat wnt PF00110.17 NM_011720.3_1 - 2.1e-94 316.4 19.5 2.9e-94 315.9 19.5 1.1 1 0 0 1 1 1 1 wnt family MEF2_binding PF09047.8 NM_011720.3_3 - 1 9.1 4.2 0.39 10.5 1.2 1.8 2 0 0 2 2 2 0 MEF2 binding NLPC_P60 PF00877.17 NM_001193274.1_1 - 0.0002 21.2 0.0 0.00029 20.7 0.0 1.3 1 0 0 1 1 1 1 NlpC/P60 family LRAT PF04970.11 NM_001193274.1_1 - 0.00087 19.5 0.2 0.0072 16.5 0.2 2.0 1 1 0 1 1 1 1 Lecithin retinol acyltransferase CHAP PF05257.14 NM_001193274.1_1 - 0.025 15.0 0.0 0.1 13.1 0.0 1.9 2 0 0 2 2 2 0 CHAP domain DUF1175 PF06672.9 NM_001193274.1_1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1175) Peptidase_M44 PF03410.11 NM_001193274.1_1 - 0.21 10.0 0.0 0.27 9.6 0.0 1.0 1 0 0 1 1 1 0 Metallopeptidase from vaccinia pox Dapper PF15268.4 NM_001190466.1_2 - 1.1e-237 791.7 34.0 1.4e-236 788.1 34.0 1.9 1 1 0 1 1 1 1 Dapper LURAP PF14854.4 NM_001190466.1_2 - 0.0053 16.6 0.7 0.013 15.3 0.7 1.6 1 0 0 1 1 1 1 Leucine rich adaptor protein DUF4530 PF15039.4 NM_001190466.1_2 - 0.033 14.2 0.5 0.078 13.0 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) Anillin PF08174.9 NM_133641.2_3 - 9.2e-44 149.2 0.0 1.4e-43 148.6 0.0 1.3 1 0 0 1 1 1 1 Cell division protein anillin HR1 PF02185.14 NM_133641.2_3 - 0.00099 19.0 2.5 0.0028 17.6 2.5 1.7 1 0 0 1 1 1 1 Hr1 repeat PH PF00169.27 NM_133641.2_3 - 0.012 16.0 0.0 0.029 14.7 0.0 1.6 1 0 0 1 1 1 0 PH domain G_glu_transpept PF01019.19 NM_008116.3_1 - 1.1e-181 605.0 0.0 1.2e-181 604.8 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase TIR PF01582.18 NM_008365.2_3 - 4.3e-36 124.2 0.0 8.1e-36 123.3 0.0 1.4 1 0 0 1 1 1 1 TIR domain Ig_2 PF13895.4 NM_008365.2_3 - 5.9e-16 58.4 5.7 1.1e-05 25.5 0.1 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 NM_008365.2_3 - 2.4e-08 34.3 3.0 0.0012 19.3 0.1 3.7 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 NM_008365.2_3 - 7.5e-07 29.2 3.9 0.25 11.4 0.0 4.6 3 2 1 4 4 4 3 Immunoglobulin V-set domain I-set PF07679.14 NM_008365.2_3 - 1.2e-05 25.2 1.2 0.28 11.1 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.23 NM_008365.2_3 - 3.2e-05 23.9 14.0 0.03 14.3 0.1 4.3 4 0 0 4 4 4 3 Immunoglobulin domain TIR_2 PF13676.4 NM_008365.2_3 - 0.00066 19.8 0.0 0.0013 18.9 0.0 1.4 1 0 0 1 1 1 1 TIR domain HLH PF00010.24 NM_001001714.1_3 - 7.2e-05 22.5 0.1 0.00014 21.6 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain YL1 PF05764.11 NM_009336.2_3 - 3e-53 181.3 15.7 3.8e-53 181.0 15.7 1.1 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.9 NM_009336.2_3 - 2.2e-12 46.3 0.6 4.1e-12 45.5 0.6 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Roc PF08477.11 NM_001042499.1_1 - 6.5e-15 55.3 0.0 1.8e-14 53.9 0.0 1.7 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_001042499.1_1 - 6.6e-13 48.4 0.0 1.7e-12 47.1 0.0 1.6 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.21 NM_001042499.1_1 - 2.1e-05 24.4 0.0 3.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_001042499.1_1 - 6.1e-05 22.4 0.0 0.00011 21.5 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.19 NM_001042499.1_1 - 0.00043 19.6 0.0 0.001 18.4 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 NM_001042499.1_1 - 0.0044 16.8 0.2 0.014 15.2 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.4 NM_001042499.1_1 - 0.0092 16.2 0.0 0.031 14.5 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain IIGP PF05049.11 NM_001042499.1_1 - 0.033 13.1 0.1 0.06 12.3 0.1 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.4 NM_001042499.1_1 - 0.067 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.12 NM_001042499.1_1 - 0.07 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.25 NM_001042499.1_1 - 0.14 12.6 0.0 0.25 11.7 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.24 NM_001042499.1_1 - 0.21 11.2 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.11 NM_001042499.1_1 - 0.23 10.5 0.2 0.36 9.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) FixP_N PF14715.4 NM_001042499.1_1 - 8.7 6.1 7.5 18 5.1 7.5 1.5 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP SMAP PF15477.4 NM_019772.2_3 - 2.4e-11 44.3 1.5 2.4e-11 44.3 1.5 1.7 2 0 0 2 2 2 1 Small acidic protein family RNA_polI_A34 PF08208.9 NM_019772.2_3 - 0.094 12.7 6.5 0.14 12.1 6.5 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 BUD22 PF09073.8 NM_019772.2_3 - 0.37 10.0 16.9 0.49 9.6 16.9 1.1 1 0 0 1 1 1 0 BUD22 DUF3408 PF11888.6 NM_019772.2_3 - 7.2 6.6 7.4 0.5 10.4 2.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) MBOAT PF03062.17 NM_001083341.1_3 - 2.4e-30 105.9 13.6 3.5e-30 105.4 13.6 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family L27 PF02828.14 NM_011699.3_2 - 6.4e-22 76.9 0.2 1.1e-21 76.2 0.2 1.4 1 0 0 1 1 1 1 L27 domain PDZ PF00595.22 NM_011699.3_2 - 1.1e-19 70.4 0.6 1.6e-19 69.9 0.6 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_011699.3_2 - 0.059 13.6 0.0 0.099 12.8 0.0 1.2 1 0 0 1 1 1 0 PDZ domain DUF4821 PF16092.3 NM_175280.3_1 - 4.1e-77 259.3 0.3 5.1e-77 259.0 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4821) Chisel PF15355.4 NM_001252591.2_3 - 5.3e-43 145.0 3.9 7.7e-43 144.5 3.9 1.2 1 0 0 1 1 1 1 Stretch-responsive small skeletal muscle X protein, Chisel Ank_2 PF12796.5 NM_023773.2_3 - 1.4e-18 67.2 4.3 1.6e-10 41.3 0.7 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_023773.2_3 - 1.2e-16 60.4 1.8 1.5e-07 31.4 0.0 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_023773.2_3 - 6e-14 52.1 0.9 2.6e-06 27.8 0.0 3.6 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Chromo PF00385.22 NM_023773.2_3 - 4.8e-13 48.7 1.0 4.8e-13 48.7 1.0 2.6 3 0 0 3 3 3 1 Chromo (CHRromatin Organisation MOdifier) domain Ank_3 PF13606.4 NM_023773.2_3 - 6.3e-12 44.4 0.8 1.5e-05 24.8 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.28 NM_023773.2_3 - 6.3e-09 35.8 0.7 0.00038 20.6 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat COesterase PF00135.26 NM_198171.2_2 - 4.3e-169 563.6 0.0 4.9e-169 563.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 NM_198171.2_2 - 1.1e-09 38.4 2.1 2.1e-09 37.4 0.5 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_198171.2_2 - 9e-06 25.2 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF3498 PF12004.6 NM_177644.5_1 - 2.6e-198 660.4 51.3 2.6e-198 660.4 51.3 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3498) RasGAP PF00616.17 NM_177644.5_1 - 6.9e-26 91.1 9.8 2.4e-16 59.9 0.7 3.2 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.28 NM_177644.5_1 - 1e-08 35.3 0.1 1.8e-08 34.5 0.1 1.4 1 0 0 1 1 1 1 C2 domain PH PF00169.27 NM_177644.5_1 - 0.00056 20.3 0.0 0.97 9.9 0.0 3.2 2 0 0 2 2 2 2 PH domain Bacillus_HBL PF05791.9 NM_177644.5_1 - 0.19 11.3 8.4 0.43 10.2 8.4 1.5 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) FAM76 PF16046.3 NM_177644.5_1 - 0.3 10.3 16.1 0.66 9.1 16.1 1.5 1 0 0 1 1 1 0 FAM76 protein XLF PF09302.9 NM_177644.5_1 - 0.66 10.0 9.9 1.5 8.9 9.9 1.5 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component NAD_kinase PF01513.19 NM_001159637.1_3 - 2.9e-65 220.2 0.0 3.8e-65 219.8 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.22 NM_001159637.1_3 - 0.13 11.7 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain RF-1 PF00472.18 NM_028310.3_1 - 8.2e-09 35.3 0.0 1.4e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 RF-1 domain Acetyltransf_1 PF00583.23 NM_001291865.1_2 - 2e-13 50.4 0.0 3.2e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 NM_001291865.1_2 - 2.4e-06 27.7 0.0 3.9e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 NM_001291865.1_2 - 0.00013 21.7 0.0 0.00019 21.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 NM_001291865.1_2 - 0.098 12.5 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 FR47-like protein DUF4564 PF15169.4 NM_001252548.1_1 - 1.3e-82 275.8 0.0 2.1e-82 275.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) SR-25 PF10500.7 NM_001252548.1_2 - 1.7 8.1 18.2 2.3 7.6 18.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.23 NM_023058.3_3 - 1.9e-46 158.4 0.0 2.5e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_023058.3_3 - 4.6e-21 75.1 0.0 6e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_023058.3_3 - 1.1e-08 34.6 0.0 3.5e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.4 NM_023058.3_3 - 0.015 14.8 0.0 2 7.8 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Methyltr_RsmB-F PF01189.15 NM_145354.5_3 - 5.2e-38 130.6 0.0 3.7e-37 127.8 0.0 2.0 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.17 NM_145354.5_3 - 0.048 13.6 0.0 0.096 12.7 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase RPEL PF02755.13 NM_001082536.1_3 - 6.1e-24 82.8 8.1 4.2e-08 32.5 0.1 3.8 3 0 0 3 3 3 3 RPEL repeat SAP PF02037.25 NM_001082536.1_3 - 1.2e-12 47.2 0.5 3.1e-12 45.8 0.5 1.8 1 0 0 1 1 1 1 SAP domain MPS2 PF17060.3 NM_001082536.1_3 - 0.27 10.3 1.1 0.4 9.7 0.0 1.8 2 0 0 2 2 2 0 Monopolar spindle protein 2 Homeobox PF00046.27 NM_001042438.2_2 - 5.1e-33 112.6 14.6 2.8e-07 30.1 0.0 5.4 5 0 0 5 5 5 5 Homeobox domain Homez PF11569.6 NM_001042438.2_2 - 7.6e-19 66.8 5.6 5.7e-11 41.6 0.3 5.4 5 0 0 5 5 5 5 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.9 NM_001042438.2_2 - 9.8e-18 63.6 6.3 0.0011 18.7 0.1 5.6 5 0 0 5 5 5 5 Homeobox KN domain BPS PF08947.8 NM_016719.1_3 - 7.7e-29 99.1 0.1 1.7e-28 98.0 0.1 1.6 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 NM_016719.1_3 - 1.4e-15 56.9 0.0 2.6e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 NM_016719.1_3 - 2.2e-15 56.9 0.2 8.7e-15 55.0 0.2 2.0 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 NM_016719.1_3 - 2.6e-12 47.0 0.0 2.4e-11 43.9 0.0 2.4 2 0 0 2 2 2 1 PH domain Peptidase_C1 PF00112.21 NM_022326.3_2 - 3.3e-69 233.2 0.3 4.1e-69 232.9 0.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 NM_022326.3_2 - 7.9e-14 51.7 0.3 7.9e-14 51.7 0.3 1.6 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 NM_022326.3_2 - 0.00044 19.0 1.0 0.0014 17.4 0.2 1.9 2 0 0 2 2 2 1 Peptidase C1-like family CD34_antigen PF06365.10 NM_001111059.1_2 - 2.7e-66 223.0 6.8 1.5e-48 165.0 0.5 2.2 2 0 0 2 2 2 2 CD34/Podocalyxin family BTB PF00651.29 NM_001163731.1_1 - 1.4e-28 99.2 0.1 3e-28 98.1 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain MATH PF00917.24 NM_001163731.1_1 - 0.0044 17.0 0.2 0.03 14.3 0.1 2.1 2 0 0 2 2 2 1 MATH domain BACK PF07707.13 NM_001163731.1_1 - 0.011 15.7 0.1 0.26 11.3 0.1 2.3 2 0 0 2 2 2 0 BTB And C-terminal Kelch DUF2650 PF10853.6 NM_173742.3_3 - 0.029 14.0 1.5 0.048 13.3 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2650) TEA PF01285.16 NM_001098226.3_3 - 1.6e-26 93.3 0.3 3.3e-26 92.3 0.1 1.5 2 0 0 2 2 2 1 TEA/ATTS domain family AAA_5 PF07728.12 NM_173758.3_2 - 1.6e-104 345.5 0.0 3.7e-42 143.5 0.0 3.5 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 NM_173758.3_2 - 4.8e-07 30.2 2.1 0.37 11.0 0.0 5.4 5 1 1 6 6 5 2 AAA ATPase domain CbbQ_C PF08406.8 NM_173758.3_2 - 6.7e-07 29.4 0.0 0.066 13.3 0.1 2.9 2 0 0 2 2 2 2 CbbQ/NirQ/NorQ C-terminal AAA_22 PF13401.4 NM_173758.3_2 - 2.7e-05 24.3 0.7 0.55 10.4 0.0 4.4 3 2 1 4 4 4 2 AAA domain AAA PF00004.27 NM_173758.3_2 - 3.2e-05 24.2 0.1 0.029 14.7 0.0 3.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.4 NM_173758.3_2 - 4.1e-05 23.5 0.0 0.018 15.0 0.0 3.2 2 1 1 3 3 3 1 AAA domain AAA_3 PF07726.9 NM_173758.3_2 - 6.5e-05 22.7 0.0 0.034 13.9 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.19 NM_173758.3_2 - 0.00014 21.2 0.2 1.3 8.2 0.0 3.7 4 0 0 4 4 4 2 Magnesium chelatase, subunit ChlI TniB PF05621.9 NM_173758.3_2 - 0.003 16.7 0.0 3.1 6.8 0.0 2.7 2 0 0 2 2 2 2 Bacterial TniB protein TsaE PF02367.15 NM_173758.3_2 - 0.0072 16.2 0.0 0.33 10.8 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.25 NM_173758.3_2 - 0.0079 16.6 0.0 8 6.8 0.0 3.0 2 0 0 2 2 2 1 ABC transporter AAA_2 PF07724.12 NM_173758.3_2 - 0.0098 15.9 0.0 7.1 6.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_28 PF13521.4 NM_173758.3_2 - 0.011 15.9 0.0 0.026 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Roc PF08477.11 NM_173758.3_2 - 0.014 15.5 0.2 1 9.5 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.23 NM_173758.3_2 - 0.031 13.8 0.0 1.8 8.0 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.4 NM_173758.3_2 - 0.058 13.8 0.0 0.66 10.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.4 NM_173758.3_2 - 0.061 13.3 0.0 10 6.1 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_29 PF13555.4 NM_173758.3_2 - 0.18 11.4 0.0 6.2 6.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain RNA_helicase PF00910.20 NM_173758.3_2 - 0.19 12.0 0.0 1.6 9.0 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_19 PF13245.4 NM_173758.3_2 - 0.21 11.8 1.9 11 6.2 0.0 3.3 2 1 0 2 2 2 0 AAA domain Collagen PF01391.16 NM_007741.2_3 - 8.1e-93 304.0 354.1 2.1e-09 36.9 35.0 12.4 3 3 9 12 12 12 12 Collagen triple helix repeat (20 copies) WD40 PF00400.30 NM_175180.3_2 - 1.2e-23 82.7 8.7 0.00034 21.2 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_175180.3_2 - 1.2e-05 25.4 0.1 0.76 10.0 0.0 4.4 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_C1 PF00112.21 NM_012033.3_1 - 8e-50 169.8 3.2 8e-50 169.8 3.2 1.6 2 0 0 2 2 2 1 Papain family cysteine protease Somatomedin_B PF01033.15 NM_012033.3_1 - 6e-06 26.4 21.3 6e-06 26.4 21.3 2.8 3 0 0 3 3 3 1 Somatomedin B domain Pacifastin_I PF05375.11 NM_012033.3_1 - 6.3e-06 25.7 1.6 2.6e-05 23.7 1.6 2.1 1 0 0 1 1 1 1 Pacifastin inhibitor (LCMII) Peptidase_C1_2 PF03051.13 NM_012033.3_1 - 0.0065 15.1 0.1 0.016 13.9 0.1 1.7 1 0 0 1 1 1 1 Peptidase C1-like family Propeptide_C1 PF08127.11 NM_012033.3_1 - 0.018 14.8 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Peptidase family C1 propeptide RRM_1 PF00076.20 NM_001163397.1_2 - 6.5e-64 211.6 0.1 2.5e-20 71.9 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001163397.1_2 - 2e-12 46.6 0.0 9.1e-05 21.9 0.0 3.3 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_001163397.1_2 - 0.046 13.4 0.0 7 6.5 0.0 3.1 3 0 0 3 3 3 0 Occluded RNA-recognition motif Frag1 PF10277.7 NM_026013.3_2 - 2.6e-51 174.1 14.9 2.6e-51 174.1 14.9 1.6 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family Bac_export_2 PF01312.17 NM_026013.3_2 - 1.7 7.7 7.4 2.6 7.0 7.4 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Urm1 PF09138.9 NM_026615.4_1 - 5.5e-38 129.1 0.0 7.6e-38 128.6 0.0 1.2 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.18 NM_026615.4_1 - 0.069 13.7 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 ThiS family Thiolase_N PF00108.21 NM_146230.3_1 - 2.4e-87 292.4 1.0 3.8e-87 291.8 1.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 NM_146230.3_1 - 6.2e-51 171.1 0.3 1.4e-50 170.0 0.3 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.8 NM_146230.3_1 - 8.8e-05 22.5 0.0 0.00025 21.0 0.0 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.24 NM_146230.3_1 - 0.0023 17.4 2.5 0.019 14.5 0.1 3.0 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.8 NM_146230.3_1 - 0.019 14.7 0.7 5.8 6.7 0.1 2.8 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SPDY PF03771.14 NM_146230.3_1 - 0.093 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF317) RanGAP1_C PF07834.9 NM_011241.4_1 - 2.8e-72 242.0 0.1 5.1e-72 241.1 0.1 1.5 1 0 0 1 1 1 1 RanGAP1 C-terminal domain LRR_6 PF13516.4 NM_011241.4_1 - 2.3e-14 52.0 4.4 0.29 11.1 0.0 9.0 9 0 0 9 9 9 3 Leucine Rich repeat LRR_4 PF12799.5 NM_011241.4_1 - 4.6e-05 23.5 2.7 3.6 8.0 0.0 5.0 4 2 1 5 5 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_011241.4_1 - 0.00032 20.3 0.0 0.71 9.6 0.0 4.3 4 1 0 4 4 4 1 Leucine rich repeat SDA1 PF05285.10 NM_011241.4_1 - 0.0029 17.0 12.4 0.0051 16.2 12.4 1.3 1 0 0 1 1 1 1 SDA1 LRR_1 PF00560.31 NM_011241.4_1 - 0.0043 17.2 0.4 51 4.8 0.0 5.4 5 0 0 5 5 5 0 Leucine Rich Repeat CPSF100_C PF13299.4 NM_011241.4_1 - 0.013 15.6 4.9 0.025 14.6 4.9 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Nop14 PF04147.10 NM_011241.4_1 - 0.04 12.0 18.3 0.057 11.5 18.3 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.11 NM_011241.4_1 - 0.15 10.0 25.7 0.24 9.3 25.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi BUD22 PF09073.8 NM_011241.4_1 - 0.3 10.2 15.5 0.49 9.5 15.5 1.3 1 0 0 1 1 1 0 BUD22 Mpp10 PF04006.10 NM_011241.4_1 - 0.4 9.0 18.6 0.6 8.4 18.6 1.1 1 0 0 1 1 1 0 Mpp10 protein PI3K_1B_p101 PF10486.7 NM_011241.4_1 - 0.73 7.4 4.3 1 6.9 4.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CobT PF06213.10 NM_011241.4_1 - 0.95 8.7 25.0 0.36 10.0 22.3 1.6 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT RNA_pol_Rpc4 PF05132.12 NM_011241.4_1 - 1 9.7 4.0 1.8 8.8 4.0 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC27 PF09507.8 NM_011241.4_1 - 1.1 8.4 10.9 1.8 7.7 10.9 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 NOA36 PF06524.10 NM_011241.4_1 - 1.3 8.2 21.8 2.4 7.3 21.8 1.3 1 0 0 1 1 1 0 NOA36 protein Roughex PF06020.9 NM_011241.4_1 - 1.9 7.4 13.9 3 6.7 13.9 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF1510 PF07423.9 NM_011241.4_1 - 2.5 7.4 18.0 4.7 6.5 18.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Tim54 PF11711.6 NM_011241.4_1 - 2.7 6.6 5.5 3.9 6.0 5.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Cnd2 PF05786.12 NM_011241.4_1 - 3.3 6.1 12.7 4.9 5.5 12.7 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 CDC45 PF02724.12 NM_011241.4_1 - 5.4 5.1 17.1 8.1 4.5 17.1 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.10 NM_011241.4_1 - 5.8 6.5 9.4 11 5.6 9.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.10 NM_011241.4_1 - 7.6 5.2 7.1 10 4.8 5.8 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) XAP5 PF04921.12 NM_011241.4_1 - 8.3 6.1 7.2 14 5.3 7.2 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator UPF0544 PF15749.3 NM_011241.4_1 - 9.3 6.9 6.2 23 5.6 6.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0544 Paf1 PF03985.11 NM_011241.4_1 - 9.5 5.0 21.0 13 4.5 21.0 1.1 1 0 0 1 1 1 0 Paf1 Thymosin PF01290.18 NM_011241.4_2 - 4.7 6.9 5.9 8.7 6.0 5.9 1.3 1 0 0 1 1 1 0 Thymosin beta-4 family 7tm_1 PF00001.19 NM_008106.2_3 - 4.5e-39 134.2 14.8 6e-39 133.7 14.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srt PF10321.7 NM_008106.2_3 - 1e-05 24.5 20.1 0.0049 15.7 6.9 2.2 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srt 7TM_GPCR_Srw PF10324.7 NM_008106.2_3 - 0.00039 19.7 9.1 0.00083 18.6 9.0 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 NM_008106.2_3 - 0.00056 19.2 11.6 0.00087 18.6 11.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 NM_008106.2_3 - 0.0043 16.3 8.5 0.29 10.4 4.2 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Cytochrom_B_N_2 PF13631.4 NM_008106.2_3 - 0.0048 16.8 1.3 0.011 15.6 0.2 2.0 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB DUF898 PF05987.11 NM_008106.2_3 - 6 5.7 14.4 0.24 10.3 4.4 2.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF898) Mtp PF03821.14 NM_010686.3_1 - 8.2e-114 378.9 12.7 1.1e-113 378.5 12.7 1.1 1 0 0 1 1 1 1 Golgi 4-transmembrane spanning transporter FAM47 PF14642.4 NM_010686.3_1 - 0.00023 20.6 29.7 0.064 12.6 13.2 2.3 1 1 1 2 2 2 2 FAM47 family DUF4728 PF15860.3 NM_010686.3_1 - 0.35 11.4 18.7 0.2 12.1 1.3 3.0 2 1 0 3 3 3 0 Domain of unknown function (DUF4728) FAM47 PF14642.4 NM_010686.3_2 - 2.3e-05 23.9 29.0 0.011 15.2 10.6 2.2 1 1 1 2 2 2 2 FAM47 family Drf_FH1 PF06346.10 NM_010686.3_2 - 0.0049 16.4 44.2 0.27 10.8 23.0 2.2 1 1 1 2 2 2 2 Formin Homology Region 1 PRAS PF15798.3 NM_001290695.1_2 - 2.5e-48 163.6 1.3 3.5e-48 163.1 1.3 1.2 1 0 0 1 1 1 1 Proline-rich AKT1 substrate 1 Pro_isomerase PF00160.19 NM_134084.1_3 - 1.9e-47 161.3 0.1 2.5e-47 161.0 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pou PF00157.15 NM_008899.2_2 - 1.6e-37 127.2 0.2 2.9e-37 126.4 0.2 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 NM_008899.2_2 - 5.7e-18 64.3 0.3 1.4e-17 63.1 0.3 1.7 1 0 0 1 1 1 1 Homeobox domain DUF2722 PF10846.6 NM_008899.2_2 - 0.00044 19.2 6.7 0.00068 18.6 6.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Homeobox_KN PF05920.9 NM_008899.2_2 - 0.069 12.9 0.0 0.2 11.4 0.0 1.8 1 0 0 1 1 1 0 Homeobox KN domain Spt20 PF12090.6 NM_008899.2_2 - 0.25 10.8 20.7 0.45 10.0 20.7 1.3 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.6 NM_008899.2_2 - 6.5 5.7 12.1 11 5.0 12.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Suf PF05843.12 NM_008899.2_2 - 7 6.4 9.9 12 5.6 9.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SARAF PF06682.10 NM_008899.2_2 - 8.4 5.8 15.4 25 4.3 0.1 2.4 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4659 PF15558.4 NM_001033547.2_2 - 8.1e-117 390.1 74.3 1.1e-116 389.6 74.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4659) Peptidase_C12 PF01088.19 NM_016723.2_2 - 6.7e-68 228.4 0.1 7.7e-68 228.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 IF3_C PF00707.20 NM_029581.4_1 - 6.2e-11 42.0 0.2 1.3e-10 41.0 0.2 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.14 NM_029581.4_1 - 2.6e-10 40.3 0.1 2.6e-10 40.3 0.1 1.9 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain LRR_4 PF12799.5 NM_028938.2_1 - 9.8e-10 38.4 11.5 2.4e-06 27.6 3.5 2.8 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_028938.2_1 - 4.5e-06 26.1 0.4 4.5e-06 26.1 0.4 2.3 2 0 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.4 NM_028938.2_1 - 2.8e-05 23.7 2.1 7.4e-05 22.3 2.1 1.7 1 0 0 1 1 1 1 Leucine rich repeat IQ PF00612.25 NM_028938.2_1 - 0.00077 18.9 0.7 0.0026 17.3 0.7 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif adh_short PF00106.23 NM_001122683.1_3 - 6.3e-41 139.8 0.0 9.2e-41 139.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 NM_001122683.1_3 - 3.2e-24 85.7 0.0 4.9e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 NM_001122683.1_3 - 1.9e-06 27.8 0.0 3.2e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.8 NM_001122683.1_3 - 3.7e-06 26.4 0.0 1.6e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) V-set PF07686.15 NM_001103199.1_1 - 3.1e-13 49.7 0.0 8.8e-13 48.2 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001103199.1_1 - 8.8e-10 38.9 0.7 1.1e-05 25.8 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 NM_001103199.1_1 - 9.6e-05 22.2 0.0 0.033 14.1 0.0 3.4 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 NM_001103199.1_1 - 0.00015 21.7 0.0 0.0038 17.2 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 NM_001103199.1_1 - 0.013 15.4 0.0 0.051 13.5 0.0 2.0 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF1539 PF07560.9 NM_001103199.1_1 - 0.21 11.6 71.4 1.4 8.9 3.8 10.1 3 2 4 8 8 8 0 Domain of Unknown Function (DUF1539) P53_C PF11619.6 NM_001103199.1_1 - 3.5 7.6 41.7 35 4.4 0.0 14.7 8 4 9 19 19 19 0 Transcription factor P53 - C terminal domain DUF1979 PF09322.8 NM_001103199.1_3 - 0.032 14.0 0.5 1.4e+02 2.3 0.0 5.6 7 0 0 7 7 7 0 Domain of unknown function (DUF1979) SLBP_RNA_bind PF15247.4 NM_001103199.1_3 - 1.7 8.7 14.2 24 5.0 0.0 6.9 8 1 1 9 9 9 0 Histone RNA hairpin-binding protein RNA-binding domain zf-H2C2_2 PF13465.4 NM_028538.1_1 - 8.2e-131 421.0 194.1 3.2e-07 30.4 0.5 25.0 23 1 1 24 24 24 24 Zinc-finger double domain zf-C2H2 PF00096.24 NM_028538.1_1 - 4.6e-87 281.8 180.0 9.2e-07 28.9 1.5 23.2 24 0 0 24 24 23 21 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_028538.1_1 - 2.4e-46 152.2 172.3 0.0007 20.1 0.4 22.6 22 0 0 22 22 21 21 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_028538.1_1 - 7.5e-26 89.4 154.5 0.00081 19.1 0.1 22.2 22 0 0 22 22 22 15 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_028538.1_1 - 4.6e-15 55.3 116.4 0.042 13.8 1.2 14.6 7 4 4 14 14 14 11 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_028538.1_1 - 2.2e-07 30.8 121.1 0.0022 18.1 0.0 20.4 21 0 0 21 21 21 8 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_028538.1_1 - 0.00022 21.4 0.3 0.00022 21.4 0.3 13.6 15 0 0 15 15 15 2 Zinc-finger of C2H2 type Gag_p30 PF02093.14 NM_028538.1_1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Gag P30 core shell protein zinc_ribbon_15 PF17032.3 NM_028538.1_1 - 0.38 11.4 95.3 0.39 11.4 1.2 11.6 3 3 5 11 11 11 0 zinc-ribbon family Zn_Tnp_IS1595 PF12760.5 NM_028538.1_1 - 2.1 8.3 121.1 0.3 11.0 1.3 14.6 11 4 5 16 16 16 0 Transposase zinc-ribbon domain Cys_rich_CPXG PF14255.4 NM_028538.1_1 - 3.7 7.4 13.6 0.1 12.4 0.1 5.2 3 2 2 5 5 5 0 Cysteine-rich CPXCG zf-H2C2_2 PF13465.4 NM_028538.1_2 - 2.2e-07 30.9 10.6 1.5e-05 25.0 1.7 2.8 2 0 0 2 2 2 2 Zinc-finger double domain Zn-ribbon_8 PF09723.8 NM_028538.1_2 - 0.022 14.8 1.6 4.9 7.2 0.1 2.5 2 0 0 2 2 2 0 Zinc ribbon domain IncA PF04156.12 NM_007654.2_1 - 0.00038 20.2 18.0 0.00098 18.8 18.0 1.6 1 1 0 1 1 1 1 IncA protein Exonuc_VII_L PF02601.13 NM_007654.2_1 - 0.00087 18.8 3.2 0.0014 18.1 3.2 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit Lectin_C PF00059.19 NM_007654.2_1 - 0.0016 19.1 10.8 0.12 13.0 0.1 3.0 2 2 1 3 3 3 2 Lectin C-type domain OmpH PF03938.12 NM_007654.2_1 - 0.012 15.5 9.3 0.019 14.8 9.3 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HemX PF04375.12 NM_007654.2_1 - 0.038 13.2 7.6 0.066 12.4 7.6 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4446 PF14584.4 NM_007654.2_1 - 0.061 13.2 0.3 0.061 13.2 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF342 PF03961.11 NM_007654.2_1 - 0.11 10.9 4.9 0.16 10.4 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) MAD PF05557.11 NM_007654.2_1 - 0.15 10.3 14.4 0.23 9.6 14.4 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein AAA_11 PF13086.4 NM_007654.2_1 - 0.17 11.4 7.5 0.3 10.7 7.5 1.3 1 0 0 1 1 1 0 AAA domain Macoilin PF09726.7 NM_007654.2_1 - 0.18 10.2 13.8 0.25 9.7 13.8 1.1 1 0 0 1 1 1 0 Transmembrane protein TACC PF05010.12 NM_007654.2_1 - 0.2 11.3 14.2 0.13 11.9 11.0 1.9 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) V_ATPase_I PF01496.17 NM_007654.2_1 - 0.2 9.4 3.5 0.28 8.9 3.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ATG16 PF08614.9 NM_007654.2_1 - 0.22 11.5 17.5 0.45 10.5 17.5 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.10 NM_007654.2_1 - 0.32 10.8 2.8 0.59 10.0 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IFT20 PF14931.4 NM_007654.2_1 - 0.39 10.8 12.0 0.61 10.1 11.1 1.7 2 0 0 2 2 1 0 Intraflagellar transport complex B, subunit 20 Ly49 PF08391.8 NM_007654.2_1 - 0.47 10.7 9.1 0.38 11.0 5.5 2.3 2 1 0 2 2 2 0 Ly49-like protein, N-terminal region APG6 PF04111.10 NM_007654.2_1 - 0.56 9.4 12.2 0.99 8.6 12.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.9 NM_007654.2_1 - 0.97 8.1 14.5 1.6 7.4 14.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Peptidase_S64 PF08192.9 NM_007654.2_1 - 0.99 7.7 4.9 3.6 5.8 0.0 2.1 2 0 0 2 2 2 0 Peptidase family S64 CENP-K PF11802.6 NM_007654.2_1 - 1.4 8.3 12.7 0.91 8.9 10.7 1.5 2 0 0 2 2 2 0 Centromere-associated protein K DUF4398 PF14346.4 NM_007654.2_1 - 1.5 9.4 13.4 2.8 8.5 13.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) DegS PF05384.9 NM_007654.2_1 - 1.6 8.1 14.2 3.1 7.1 14.2 1.4 1 0 0 1 1 1 0 Sensor protein DegS HIP1_clath_bdg PF16515.3 NM_007654.2_1 - 2.8 8.5 19.5 0.32 11.5 13.7 2.3 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.4 NM_007654.2_1 - 5.1 6.2 14.4 7.5 5.7 14.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.14 NM_007654.2_1 - 5.5 5.6 7.6 11 4.6 7.6 1.5 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF3391 PF11871.6 NM_007654.2_1 - 6.1 7.3 9.5 12 6.3 9.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Cupin_4 PF08007.10 NM_023633.3_1 - 9.2e-82 274.9 0.1 1.1e-81 274.6 0.1 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.4 NM_023633.3_1 - 1.3e-06 28.3 0.0 0.0002 21.1 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain Cupin_1 PF00190.20 NM_023633.3_1 - 0.056 12.9 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 Cupin Cupin_2 PF07883.9 NM_023633.3_1 - 0.15 11.6 0.0 0.62 9.7 0.0 1.9 2 0 0 2 2 2 0 Cupin domain Med19 PF10278.7 NM_025885.3_2 - 5.6e-83 277.1 14.0 7.6e-83 276.7 14.0 1.2 1 0 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 RNA_polI_A34 PF08208.9 NM_025885.3_2 - 4.5 7.2 23.7 7.7 6.4 23.7 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Myelin_MBP PF01669.15 NM_001025245.1_1 - 1.4e-17 64.5 0.4 3.1e-17 63.5 0.4 1.5 1 0 0 1 1 1 1 Myelin basic protein Ank_5 PF13857.4 NM_017375.3_2 - 2.4e-20 72.2 2.3 5.2e-08 32.9 0.5 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 NM_017375.3_2 - 3.6e-16 59.4 0.3 1.3e-15 57.6 0.2 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) SH3_1 PF00018.26 NM_017375.3_2 - 3e-15 55.4 0.0 6.8e-15 54.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain Ank_4 PF13637.4 NM_017375.3_2 - 4e-14 52.6 0.2 1.7e-06 28.4 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) SH3_9 PF14604.4 NM_017375.3_2 - 4.3e-14 52.0 0.0 7.8e-14 51.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 NM_017375.3_2 - 6.9e-13 48.0 0.0 1.8e-12 46.6 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.28 NM_017375.3_2 - 4.8e-12 45.6 0.2 2.6e-05 24.3 0.2 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 NM_017375.3_2 - 3.3e-08 33.0 0.0 0.054 13.9 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat S1-like PF14444.4 NM_027700.1_3 - 5.2e-18 64.7 0.0 1.2e-07 31.5 0.0 3.1 3 0 0 3 3 3 2 S1-like SSXRD PF09514.8 NM_001134226.1_2 - 2.8e-15 55.5 3.6 8.3e-15 53.9 3.6 1.9 1 0 0 1 1 1 1 SSXRD motif KRAB PF01352.25 NM_001134226.1_2 - 1.2e-06 27.9 0.1 2.1e-06 27.1 0.1 1.4 1 0 0 1 1 1 1 KRAB box ELO PF01151.16 NM_001134226.1_2 - 0.00055 19.4 0.0 0.00056 19.4 0.0 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family N_BRCA1_IG PF16158.3 NM_001044719.2_2 - 2.6e-32 111.4 0.1 4.3e-32 110.7 0.1 1.4 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene UBA_4 PF14555.4 NM_001044719.2_2 - 7.2e-10 38.4 0.1 1.2e-09 37.7 0.1 1.3 1 0 0 1 1 1 1 UBA-like domain Spin-Ssty PF02513.15 NM_009220.2_3 - 3.9e-64 212.1 8.8 5.5e-22 77.1 0.0 3.3 3 0 0 3 3 3 3 Spin/Ssty Family GATA PF00320.25 NM_026033.2_3 - 7.6e-05 22.1 4.2 0.0002 20.8 4.2 1.8 1 0 0 1 1 1 1 GATA zinc finger zf-HC3 PF16827.3 NM_026033.2_3 - 0.15 12.2 1.6 0.39 10.8 1.1 1.9 2 0 0 2 2 2 0 zinc-finger CHCH PF06747.11 NM_001190322.2_3 - 0.004 17.1 3.8 0.0059 16.6 3.8 1.2 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.8 NM_001190322.2_3 - 0.0046 17.0 1.2 0.0071 16.4 1.2 1.3 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type zf-HC5HC2H_2 PF13832.4 NM_001130184.1_2 - 4.1e-32 110.5 2.6 4.1e-32 110.5 2.6 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 NM_001130184.1_2 - 1.1e-27 96.0 2.0 1.1e-27 96.0 2.0 3.6 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.4 NM_001130184.1_2 - 1.5e-12 46.7 6.4 1.5e-12 46.7 6.4 3.5 3 0 0 3 3 3 1 PHD-finger PHD PF00628.27 NM_001130184.1_2 - 8.6e-10 38.2 9.4 8.6e-10 38.2 9.4 3.5 4 0 0 4 4 4 2 PHD-finger EPL1 PF10513.7 NM_001130184.1_2 - 1.7e-06 28.4 0.8 4.6e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 Enhancer of polycomb-like C1_1 PF00130.20 NM_001130184.1_2 - 0.0034 17.1 2.9 0.0034 17.1 2.9 3.3 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.14 NM_001130184.1_2 - 0.058 13.6 19.5 0.29 11.3 4.8 3.8 3 0 0 3 3 3 0 C1 domain Prok-RING_1 PF14446.4 NM_001130184.1_2 - 0.23 11.3 14.6 2.2 8.2 7.6 3.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.9 NM_001130184.1_2 - 7.2 6.9 17.0 0.15 12.3 4.0 3.1 2 0 0 2 2 2 0 RING-like domain Arf PF00025.19 NM_025404.3_2 - 7.9e-57 191.4 0.0 1e-56 191.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 NM_025404.3_2 - 1.7e-15 56.9 0.0 2.1e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_025404.3_2 - 2.6e-15 56.6 0.0 3.4e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 NM_025404.3_2 - 3e-10 39.7 0.0 4.5e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 NM_025404.3_2 - 7.1e-07 29.2 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_025404.3_2 - 0.00015 21.1 0.0 0.00022 20.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.18 NM_025404.3_2 - 0.00017 20.8 0.0 0.0003 20.0 0.0 1.4 1 1 0 1 1 1 1 G-protein alpha subunit GTP_EFTU PF00009.25 NM_025404.3_2 - 0.00046 19.7 0.0 0.0028 17.1 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain NTPase_1 PF03266.13 NM_025404.3_2 - 0.045 13.5 0.0 0.064 13.0 0.0 1.2 1 0 0 1 1 1 0 NTPase Acyltransf_C PF16076.3 NM_026644.2_3 - 7.1e-26 90.0 0.4 1.3e-25 89.2 0.4 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.19 NM_026644.2_3 - 2e-15 56.4 0.0 5.2e-15 55.1 0.0 1.6 2 0 0 2 2 2 1 Acyltransferase Mpv17_PMP22 PF04117.10 NM_001289565.1_2 - 1.6e-17 63.3 1.9 1.6e-17 63.3 1.9 2.2 2 0 0 2 2 2 1 Mpv17 / PMP22 family RRM_1 PF00076.20 NM_001038696.1_3 - 2.3e-17 62.5 0.1 6.7e-08 32.1 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001038696.1_3 - 0.069 12.6 0.1 3 7.3 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DEAD PF00270.27 NM_001293783.1_1 - 2.9e-16 59.6 0.0 7.3e-16 58.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.13 NM_001293783.1_1 - 1.2e-10 41.6 1.4 6.1e-10 39.2 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.29 NM_001293783.1_1 - 2e-08 34.5 0.1 7.7e-08 32.6 0.1 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Keratin_B2_2 PF13885.4 NM_001205034.1_1 - 2.4e-20 72.1 282.4 4.1e-06 26.5 36.1 6.9 1 1 6 7 7 7 6 Keratin, high sulfur B2 protein PMG PF05287.10 NM_001205034.1_1 - 3.6e-08 33.5 65.2 3.6e-08 33.5 65.2 3.3 1 1 1 2 2 2 1 PMG protein Keratin_B2 PF01500.15 NM_001205034.1_1 - 0.5 10.2 208.3 8.3 6.2 54.8 4.7 1 1 2 3 3 3 0 Keratin, high sulfur B2 protein PITH PF06201.11 NM_016792.4_1 - 5.6e-40 136.9 0.1 8e-40 136.4 0.1 1.2 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.18 NM_016792.4_1 - 2.4e-16 59.4 0.0 4.1e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin FERM_M PF00373.16 NM_028127.3_3 - 1e-17 64.5 0.5 2.2e-17 63.4 0.5 1.5 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.8 NM_028127.3_3 - 7.5e-14 51.8 0.0 1.6e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 NM_028127.3_3 - 4.9e-08 32.7 0.1 9.3e-08 31.8 0.1 1.5 1 0 0 1 1 1 1 FERM N-terminal domain SH2_2 PF14633.4 NM_009297.2_1 - 9.7e-86 286.5 0.2 2.4e-85 285.2 0.2 1.8 1 0 0 1 1 1 1 SH2 domain YqgF PF14639.4 NM_009297.2_1 - 1.2e-70 236.0 0.0 3.2e-70 234.6 0.0 1.8 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.4 NM_009297.2_1 - 1.4e-52 176.3 0.0 2.6e-52 175.4 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif DLD PF14878.4 NM_009297.2_1 - 8.6e-36 122.7 0.6 8.6e-36 122.7 0.6 3.1 3 0 0 3 3 3 1 Death-like domain of SPT6 HTH_44 PF14641.4 NM_009297.2_1 - 4.3e-26 91.5 1.2 1.4e-25 89.9 1.2 1.9 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.4 NM_009297.2_1 - 2.3e-14 53.6 31.1 2.3e-14 53.6 31.1 7.8 6 1 3 9 9 6 1 Acidic N-terminal SPT6 HHH_3 PF12836.5 NM_009297.2_1 - 1.6e-07 31.3 0.0 5.1e-07 29.7 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif Tex_N PF09371.8 NM_009297.2_1 - 2.1e-07 30.5 0.0 0.027 13.8 0.0 2.8 2 1 0 2 2 2 2 Tex-like protein N-terminal domain S1 PF00575.21 NM_009297.2_1 - 7.6e-07 29.2 0.1 1.7e-06 28.2 0.1 1.6 1 0 0 1 1 1 1 S1 RNA binding domain Tex_YqgF PF16921.3 NM_009297.2_1 - 5.9e-05 23.4 0.0 0.00012 22.4 0.0 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain SH2 PF00017.22 NM_009297.2_1 - 8.1e-05 22.5 0.0 0.0002 21.2 0.0 1.7 1 0 0 1 1 1 1 SH2 domain DUF5118 PF17162.2 NM_009297.2_2 - 0.1 12.3 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) ALS2CR11 PF15729.3 NM_175200.4_2 - 1.6e-176 587.4 4.6 2e-176 587.1 4.6 1.1 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 candidate 11 DUF4713 PF15831.3 NM_001253803.1_3 - 1.9e-25 88.9 13.7 2.3e-25 88.6 13.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4713) Shisa PF13908.4 NM_001253803.1_3 - 0.00021 21.5 0.1 0.00023 21.3 0.1 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Comm PF15957.3 NM_001253803.1_3 - 0.011 15.9 2.3 0.015 15.5 2.3 1.2 1 0 0 1 1 1 0 Commissureless Rhabdo_glycop PF00974.16 NM_001253803.1_3 - 0.019 13.3 0.0 0.021 13.1 0.0 1.0 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein TMEM52 PF14979.4 NM_001253803.1_3 - 0.1 12.4 4.5 0.13 12.0 4.5 1.1 1 0 0 1 1 1 0 Transmembrane 52 IncA PF04156.12 NM_001253803.1_3 - 0.12 12.0 0.2 0.12 12.0 0.2 1.7 2 0 0 2 2 2 0 IncA protein CamS PF07537.9 NM_001253803.1_3 - 0.23 10.5 0.0 0.25 10.3 0.0 1.0 1 0 0 1 1 1 0 CamS sex pheromone cAM373 precursor Mucin PF01456.15 NM_001253803.1_3 - 0.23 11.3 6.8 0.31 10.9 6.8 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein TMIE PF16038.3 NM_001253803.1_3 - 0.8 9.5 4.8 1.4 8.7 4.8 1.4 1 0 0 1 1 1 0 TMIE protein Arm PF00514.21 NM_008467.4_2 - 1.7e-87 285.0 19.8 4.4e-13 48.6 0.2 9.0 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.3 NM_008467.4_2 - 1.1e-24 85.5 2.3 4.8e-23 80.3 3.3 2.3 2 0 0 2 2 2 1 Atypical Arm repeat IBB PF01749.18 NM_008467.4_2 - 1e-22 80.1 4.4 2.5e-22 78.9 4.4 1.7 1 0 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.4 NM_008467.4_2 - 8.3e-21 73.9 3.3 6.2e-09 36.0 0.1 5.7 4 1 1 5 5 5 3 HEAT-like repeat HEAT_2 PF13646.4 NM_008467.4_2 - 7.9e-17 61.3 0.6 7.2e-06 26.2 0.0 5.9 3 2 1 5 5 5 3 HEAT repeats HEAT PF02985.20 NM_008467.4_2 - 2.2e-16 58.4 1.9 0.0087 16.1 0.0 6.4 6 0 0 6 6 6 3 HEAT repeat V-ATPase_H_C PF11698.6 NM_008467.4_2 - 1.9e-05 24.6 1.2 0.16 11.9 0.2 4.0 4 0 0 4 4 4 2 V-ATPase subunit H Cnd1 PF12717.5 NM_008467.4_2 - 2.6e-05 24.2 1.2 0.11 12.4 0.1 3.3 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.12 NM_008467.4_2 - 0.00016 20.9 1.0 0.003 16.8 0.4 2.3 1 1 0 2 2 2 1 V-ATPase subunit H Arm_2 PF04826.11 NM_008467.4_2 - 0.0032 16.8 1.1 0.54 9.5 0.3 3.2 2 1 2 4 4 4 2 Armadillo-like Atx10homo_assoc PF09759.7 NM_008467.4_2 - 0.0086 16.0 3.3 0.47 10.4 0.0 4.2 4 1 2 6 6 5 1 Spinocerebellar ataxia type 10 protein domain CTNNBL PF08216.9 NM_008467.4_2 - 0.86 9.7 3.4 20 5.3 0.2 3.3 3 0 0 3 3 3 0 Catenin-beta-like, Arm-motif containing nuclear DUF4503 PF14951.4 NM_146068.4_3 - 1.2e-175 583.5 6.4 1.7e-175 583.1 6.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4503) DUF4502 PF14950.4 NM_146068.4_3 - 1.1e-173 577.9 5.8 1.4e-173 577.5 5.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4502) Peptidase_M10 PF00413.22 NM_008608.4_2 - 1.2e-58 197.3 0.0 1.9e-58 196.7 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 NM_008608.4_2 - 1.2e-54 181.9 17.5 1.1e-13 50.7 0.8 4.8 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.6 NM_008608.4_2 - 3.2e-24 84.5 0.0 6.4e-24 83.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.16 NM_008608.4_2 - 5.7e-10 39.1 0.2 1.1e-09 38.2 0.2 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 NM_008608.4_2 - 0.0051 16.3 0.6 0.8 9.2 0.0 2.2 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) Peptidase_M54 PF07998.9 NM_008608.4_2 - 0.026 14.4 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 Metallopep PF12044.6 NM_008608.4_2 - 0.048 12.2 0.0 0.078 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family DUF4953 PF16313.3 NM_008608.4_2 - 0.048 12.7 0.1 0.074 12.1 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_3 PF13582.4 NM_008608.4_2 - 0.091 13.1 0.1 0.17 12.3 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.7 NM_008608.4_2 - 0.3 9.9 0.8 0.44 9.3 0.0 1.6 2 0 0 2 2 2 0 Peptidase M66 Eapp_C PF10238.7 NM_008608.4_2 - 1.1 9.2 3.9 1.9 8.4 3.9 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein SKG6 PF08693.8 NM_008608.4_2 - 1.3 8.3 5.6 3.2 7.1 5.6 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DDRGK PF09756.7 NM_008608.4_2 - 3.2 7.2 18.3 5.1 6.5 18.3 1.2 1 0 0 1 1 1 0 DDRGK domain DUF4366 PF14283.4 NM_008608.4_2 - 4.3 6.6 5.0 22 4.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) OATP PF03137.18 NM_008608.4_2 - 4.4 5.4 4.9 6.4 4.8 4.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Connexin PF00029.17 NM_008608.4_2 - 8.2 6.0 6.4 14 5.3 6.4 1.2 1 0 0 1 1 1 0 Connexin Rrn6 PF10214.7 NM_008608.4_3 - 0.18 10.0 11.4 0.22 9.8 10.2 1.6 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor E2F_CC-MB PF16421.3 NM_001305399.1_2 - 2.8e-34 117.3 0.3 3.9e-34 116.8 0.3 1.2 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain Ribosomal_L31e PF01198.17 NM_001258458.1_2 - 5.9e-53 176.9 1.2 8e-53 176.5 1.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e Vsr PF03852.13 NM_001258458.1_2 - 0.011 15.4 0.1 0.023 14.4 0.1 1.5 1 0 0 1 1 1 0 DNA mismatch endonuclease Vsr Headcase PF16002.3 NM_001033432.3_1 - 2e-82 275.3 4.0 3.9e-82 274.4 4.0 1.4 1 0 0 1 1 1 1 Headcase protein HECA PF15353.4 NM_001033432.3_1 - 9.5e-39 131.6 10.6 1.8e-38 130.7 10.6 1.5 1 0 0 1 1 1 1 Headcase protein family homologue SNF PF00209.16 NM_133987.2_3 - 1.1e-238 793.0 37.9 1.3e-238 792.8 37.9 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF4260 PF14079.4 NM_133987.2_3 - 1.4 8.8 4.6 0.49 10.3 0.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4260) SNAPc19 PF15497.4 NM_183316.2_2 - 1.1e-22 80.1 17.5 1.8e-22 79.4 17.5 1.4 1 0 0 1 1 1 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 DUF4724 PF15852.3 NM_183316.2_2 - 0.0043 17.2 0.1 0.0073 16.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4724) Bcl-2_BAD PF10514.7 NM_001285453.1_3 - 7.9e-89 296.3 9.0 9.8e-89 296.0 9.0 1.1 1 0 0 1 1 1 1 Pro-apoptotic Bcl-2 protein, BAD Bclx_interact PF08945.8 NM_001285453.1_3 - 0.00042 19.9 0.2 0.00088 18.9 0.2 1.6 1 0 0 1 1 1 1 Bcl-x interacting, BH3 domain EF-hand_2 PF09068.9 NM_007886.2_2 - 3.6e-35 120.6 1.5 7.1e-35 119.7 1.5 1.5 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.9 NM_007886.2_2 - 1.5e-30 105.3 0.1 3.5e-30 104.1 0.1 1.6 1 0 0 1 1 1 1 EF-hand ZZ PF00569.15 NM_007886.2_2 - 1.6e-08 34.1 12.6 3.7e-08 32.9 12.6 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF342 PF03961.11 NM_007886.2_2 - 0.023 13.2 2.5 0.036 12.6 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) CRISPR_Cse2 PF09485.8 NM_007886.2_2 - 0.026 14.9 3.1 0.056 13.8 3.1 1.6 1 0 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Mnd1 PF03962.13 NM_007886.2_2 - 0.059 13.1 9.0 0.12 12.1 9.0 1.5 1 0 0 1 1 1 0 Mnd1 family Seryl_tRNA_N PF02403.20 NM_007886.2_2 - 0.06 13.4 7.7 0.14 12.3 7.7 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain SOGA PF11365.6 NM_007886.2_2 - 0.16 13.0 9.2 0.48 11.5 9.2 1.9 1 0 0 1 1 1 0 Protein SOGA APG6 PF04111.10 NM_007886.2_2 - 0.43 9.8 5.7 0.72 9.0 5.7 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 MerR-DNA-bind PF09278.9 NM_007886.2_2 - 2.6 8.5 11.9 3.4 8.1 10.3 2.1 1 1 1 2 2 2 0 MerR, DNA binding ZapB PF06005.10 NM_007886.2_2 - 3.7 7.9 18.9 3.9 7.9 16.2 2.5 2 1 0 2 2 2 0 Cell division protein ZapB I-set PF07679.14 NM_182809.2_2 - 9.2e-20 70.4 0.0 5.1e-10 39.1 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain TPKR_C2 PF16920.3 NM_182809.2_2 - 9.4e-19 67.1 6.4 2.3e-18 65.9 6.4 1.7 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain Ig_3 PF13927.4 NM_182809.2_2 - 6.6e-17 61.8 2.0 1.1e-09 38.6 0.9 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_182809.2_2 - 1.4e-16 60.3 0.5 4.5e-15 55.5 0.3 2.4 2 0 0 2 2 2 1 Immunoglobulin domain LRR_8 PF13855.4 NM_182809.2_2 - 1.1e-12 47.4 2.7 1.1e-12 47.4 2.7 2.1 2 0 0 2 2 2 1 Leucine rich repeat Ig_2 PF13895.4 NM_182809.2_2 - 2.3e-11 43.7 1.5 5.8e-07 29.6 0.3 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 NM_182809.2_2 - 9.2e-08 31.9 0.2 0.00092 19.1 0.1 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain LRRNT PF01462.16 NM_182809.2_2 - 1.6e-06 27.5 2.2 6e-06 25.6 2.2 2.1 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.4 NM_182809.2_2 - 0.00018 21.3 0.4 0.0004 20.2 0.4 1.5 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_182809.2_2 - 0.00029 21.0 9.2 0.0024 18.1 1.8 2.3 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 NM_182809.2_2 - 0.13 12.3 0.3 0.52 10.4 0.3 2.1 1 0 0 1 1 1 0 Leucine Rich repeat LRR_1 PF00560.31 NM_182809.2_2 - 0.52 10.8 5.9 10 6.9 0.2 5.0 4 0 0 4 4 4 0 Leucine Rich Repeat zf-C4 PF00105.16 NM_009504.4_3 - 5.2e-28 97.2 15.0 9.6e-28 96.3 15.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_009504.4_3 - 2.4e-22 79.4 0.0 4e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-RRPl_C4 PF17026.3 NM_009504.4_3 - 0.44 10.5 3.9 1 9.4 3.1 1.9 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type RasGEF PF00617.17 NM_001290572.1_2 - 9.7e-49 165.7 2.0 3e-48 164.1 1.3 1.9 1 1 1 2 2 2 1 RasGEF domain PH PF00169.27 NM_001290572.1_2 - 1.2e-10 41.7 0.0 2.3e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 PH domain NID PF07292.11 NM_001141949.1_2 - 3.4e-62 207.0 4.1 4.9e-30 103.9 0.3 3.1 3 0 0 3 3 3 2 Nmi/IFP 35 domain (NID) IFP_35_N PF07334.11 NM_001141949.1_2 - 5.5e-38 128.8 5.7 1.9e-37 127.1 4.3 2.2 2 0 0 2 2 2 1 Interferon-induced 35 kDa protein (IFP 35) N-terminus M PF02370.14 NM_001141949.1_2 - 0.73 10.5 3.5 2.3 9.0 3.5 1.9 1 0 0 1 1 1 0 M protein repeat Taxilin PF09728.7 NM_001290776.1_1 - 2.9e-114 381.4 77.2 3.8e-114 381.0 77.2 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein FlaC_arch PF05377.9 NM_001290776.1_1 - 0.83 9.9 13.4 7.3 6.9 0.4 4.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF3627 PF12299.6 NM_001290776.1_1 - 8.4 6.4 14.6 0.11 12.5 5.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3627) WD40 PF00400.30 NM_023120.5_1 - 5.8e-15 55.3 2.4 0.00064 20.4 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_023120.5_1 - 5e-06 26.6 0.0 0.39 10.9 0.0 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain KH_1 PF00013.27 NM_183029.2_1 - 1.2e-54 181.9 15.7 6.1e-15 54.7 0.4 4.4 4 0 0 4 4 4 4 KH domain RRM_1 PF00076.20 NM_183029.2_1 - 1.1e-16 60.2 0.0 4.6e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_2 PF07650.15 NM_183029.2_1 - 8.2e-16 57.5 4.9 0.0039 16.9 0.1 4.6 4 0 0 4 4 4 4 KH domain KH_4 PF13083.4 NM_183029.2_1 - 8.6e-13 47.8 0.5 0.0027 17.4 0.0 4.7 4 0 0 4 4 4 4 KH domain KH_5 PF13184.4 NM_183029.2_1 - 0.00028 20.8 8.0 1.7 8.7 0.1 4.3 4 0 0 4 4 4 3 NusA-like KH domain RRM_5 PF13893.4 NM_183029.2_1 - 0.006 16.0 0.0 1.1 8.7 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MOEP19 PF16005.3 NM_183029.2_1 - 0.0082 16.0 0.0 0.51 10.3 0.0 3.1 3 0 0 3 3 3 1 KH-like RNA-binding domain VPEP PF07589.9 NM_001111286.2_2 - 0.032 14.2 0.0 0.094 12.7 0.0 1.9 1 0 0 1 1 1 0 PEP-CTERM motif HIF-1a_CTAD PF08778.8 NM_001313688.1_1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain SH2 PF00017.22 NM_001313688.1_3 - 2e-12 46.9 0.0 3.8e-12 46.0 0.0 1.6 1 1 0 1 1 1 1 SH2 domain Claudin_2 PF13903.4 NM_001199311.1_1 - 6.5e-06 25.9 9.1 1.1e-05 25.2 9.1 1.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 NM_001199311.1_1 - 0.0011 18.7 14.0 0.0055 16.5 14.0 2.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family CTV_P13 PF06922.9 NM_001199311.1_1 - 0.024 14.6 0.1 0.041 13.8 0.1 1.3 1 0 0 1 1 1 0 Citrus tristeza virus P13 protein Vinculin PF01044.17 NM_001109764.1_2 - 0 1039.5 44.8 1.6e-210 701.8 28.3 2.8 1 1 1 2 2 2 2 Vinculin family CorA PF01544.16 NM_001109764.1_2 - 1.5 8.0 4.8 1.1 8.4 0.1 2.7 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein SAWADEE PF16719.3 NM_001109764.1_2 - 2.2 8.1 5.2 0.91 9.4 0.1 2.9 3 1 1 4 4 4 0 SAWADEE domain Rotamase PF00639.19 NM_001109764.1_2 - 3.6 8.5 10.1 6.4 7.7 0.1 4.9 6 0 0 6 6 6 0 PPIC-type PPIASE domain 7tm_1 PF00001.19 NM_013461.4_2 - 2e-78 263.2 5.3 3.8e-78 262.3 5.3 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_013461.4_2 - 7.9e-16 58.1 6.2 1.7e-15 56.9 6.2 1.6 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_013461.4_2 - 0.00015 21.5 5.2 0.00021 21.0 2.6 2.0 2 0 0 2 2 2 1 Olfactory receptor Phage_holin_2_1 PF04971.10 NM_013461.4_3 - 0.14 12.1 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage P21 holin S RRM_1 PF00076.20 NM_001270516.1_2 - 1.9e-18 65.9 0.1 3.4e-18 65.1 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 NM_001270516.1_2 - 0.0011 18.9 9.8 0.0011 18.9 9.8 5.0 5 1 1 6 6 6 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 NM_001270516.1_2 - 0.0029 17.6 0.0 0.0064 16.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.4 NM_001270516.1_2 - 0.014 14.8 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTNNB1_binding PF08347.9 NM_010703.4_3 - 7e-84 280.9 4.7 7e-84 280.9 4.7 1.8 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 NM_010703.4_3 - 3.2e-21 75.4 0.7 3.2e-21 75.4 0.7 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_010703.4_3 - 9e-08 32.5 2.8 1e-07 32.3 0.8 2.0 2 0 0 2 2 2 1 HMG-box domain GMC_oxred_N PF00732.17 NM_172264.2_3 - 2.3e-95 319.2 0.0 3.2e-95 318.8 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.11 NM_172264.2_3 - 3.4e-40 137.7 0.1 5.2e-40 137.2 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.10 NM_172264.2_3 - 2.2e-05 23.6 0.0 3.4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.4 NM_172264.2_3 - 0.0002 21.4 0.0 0.0007 19.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.22 NM_172264.2_3 - 0.0022 17.0 0.1 0.24 10.3 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.22 NM_172264.2_3 - 0.01 15.4 0.5 0.025 14.1 0.5 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 NM_172264.2_3 - 0.082 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 NM_172264.2_3 - 0.17 10.4 0.0 0.24 9.9 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Trypsin PF00089.24 NM_172880.2_2 - 4.5e-67 226.0 0.2 6.3e-67 225.5 0.2 1.2 1 0 0 1 1 1 1 Trypsin SEA PF01390.18 NM_172880.2_2 - 3.1e-20 72.3 0.8 5e-20 71.6 0.1 1.7 2 0 0 2 2 2 1 SEA domain Trypsin_2 PF13365.4 NM_172880.2_2 - 1.9e-05 25.5 0.0 3.5e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_172880.2_2 - 0.00036 20.8 0.0 0.00073 19.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) LYRIC PF15686.3 NM_026002.4_3 - 3.8e-140 468.0 24.4 3.8e-140 468.0 24.4 2.3 1 1 1 2 2 2 1 Lysine-rich CEACAM1 co-isolated protein family Na_K-ATPase PF00287.16 NM_013415.5_1 - 6.4e-110 366.6 0.9 8.4e-110 366.3 0.9 1.1 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain EF-hand_8 PF13833.4 NM_145523.3_2 - 1.5e-09 37.3 0.0 6e-07 29.0 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_145523.3_2 - 2.2e-09 36.1 0.0 0.012 15.0 0.0 3.8 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 NM_145523.3_2 - 1.9e-06 27.2 0.0 0.63 10.0 0.0 3.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 NM_145523.3_2 - 1.2e-05 25.5 0.0 0.19 12.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_145523.3_2 - 0.0022 17.3 0.0 3.5 7.2 0.0 2.7 2 0 0 2 2 2 2 EF hand Kelch_4 PF13418.4 NM_001033039.2_3 - 2.9e-14 52.6 5.3 0.0013 18.5 0.0 6.2 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_3 PF13415.4 NM_001033039.2_3 - 3.4e-13 49.4 20.6 0.0019 18.3 0.7 7.8 8 0 0 8 8 8 5 Galactose oxidase, central domain Kelch_5 PF13854.4 NM_001033039.2_3 - 9.6e-13 47.7 0.5 0.00012 21.8 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.13 NM_001033039.2_3 - 1e-12 47.3 8.3 0.0016 18.2 0.1 6.2 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.4 NM_001033039.2_3 - 2e-10 40.4 3.0 0.26 11.5 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.23 NM_001033039.2_3 - 2.9e-09 36.2 10.3 0.0077 15.7 0.1 6.2 6 0 0 6 6 6 3 Kelch motif Nbas_N PF15492.4 NM_001033039.2_3 - 0.011 15.0 0.1 0.017 14.3 0.1 1.2 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal TPR_1 PF00515.26 NM_145931.2_2 - 0.0011 18.6 1.5 1.5 8.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat zf-C2H2_jaz PF12171.6 NM_145931.2_2 - 0.0013 18.9 7.7 0.0046 17.1 7.7 2.0 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_145931.2_2 - 0.015 15.5 5.4 0.05 13.9 5.4 2.0 1 0 0 1 1 1 0 Zinc-finger of C2H2 type TPR_2 PF07719.15 NM_145931.2_2 - 0.018 15.0 1.2 1.2 9.3 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-CCCH PF00642.22 NM_145931.2_2 - 0.057 13.2 24.7 0.027 14.3 2.1 4.2 4 0 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TMEM132 PF16070.3 NM_133804.2_1 - 1.3e-105 353.5 0.0 1.7e-105 353.1 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_N PF15705.3 NM_133804.2_1 - 2e-32 111.6 0.0 3.2e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term TMEM132D_C PF15706.3 NM_133804.2_1 - 3.7e-28 97.0 0.0 7.3e-28 96.1 0.0 1.4 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF2207 PF09972.7 NM_133804.2_1 - 0.032 12.9 0.0 0.061 12.0 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Fox-1_C PF12414.6 NM_001286417.1_1 - 1.2e-10 41.4 7.5 2.4e-10 40.5 7.5 1.4 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal Fox-1_C PF12414.6 NM_001286417.1_2 - 4e-22 78.2 2.8 1.2e-21 76.7 1.9 2.2 2 0 0 2 2 2 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 NM_001286417.1_2 - 1.3e-17 63.3 0.1 1.9e-17 62.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001286417.1_2 - 0.33 10.4 1.3 0.35 10.3 0.0 1.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPD PF14811.4 NM_207264.4_2 - 8e-52 174.6 0.0 1.3e-51 174.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function TPD sequence-motif Peptidase_M10 PF00413.22 NM_001320216.1_1 - 5.8e-39 133.3 0.0 8.3e-39 132.8 0.0 1.2 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.16 NM_001320216.1_1 - 5.2e-11 42.5 0.0 1.1e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Hemopexin PF00045.17 NM_001320216.1_1 - 1.1e-05 25.1 2.2 1.1e-05 25.1 2.2 2.4 2 0 0 2 2 2 1 Hemopexin Metallopep PF12044.6 NM_001320216.1_1 - 0.00075 18.1 0.0 0.0011 17.5 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family DUF4953 PF16313.3 NM_001320216.1_1 - 0.013 14.6 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 Met-zincin Astacin PF01400.22 NM_001320216.1_1 - 0.02 14.3 0.0 0.52 9.7 0.1 2.1 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 NM_001320216.1_1 - 0.049 14.0 0.4 0.073 13.4 0.4 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.9 NM_001320216.1_1 - 0.06 13.2 0.1 0.12 12.2 0.1 1.4 1 1 0 1 1 1 0 Peptidase family M54 Peptidase_M7 PF02031.14 NM_001320216.1_1 - 0.1 12.6 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family Peptidase_M66 PF10462.7 NM_001320216.1_1 - 0.14 10.9 0.0 0.21 10.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_5 PF13688.4 NM_001320216.1_1 - 0.2 11.7 0.0 0.32 11.0 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 Hemopexin PF00045.17 NM_001320216.1_2 - 6.5e-06 25.9 0.4 0.00064 19.5 0.2 2.5 2 0 0 2 2 2 2 Hemopexin V1R PF03402.12 NM_001244031.1_1 - 7.1e-12 45.4 17.0 1.2e-11 44.7 17.0 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001244031.1_1 - 1.7e-07 30.6 19.4 2.4e-07 30.0 19.4 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) HLH PF00010.24 NM_010495.3_1 - 1.6e-12 47.0 0.0 3.2e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Dsl1_N PF11988.6 NM_010495.3_1 - 0.063 12.1 0.1 0.083 11.7 0.1 1.1 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal IL6Ra-bind PF09240.8 NM_013563.4_3 - 1.2e-10 41.6 3.2 2.4e-10 40.6 3.2 1.5 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.19 NM_013563.4_3 - 3.8e-08 33.4 0.1 1e-07 32.1 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain EpoR_lig-bind PF09067.8 NM_013563.4_3 - 0.0002 21.4 1.1 0.00036 20.6 1.1 1.4 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding IL4Ra_N PF09238.8 NM_013563.4_3 - 0.014 15.6 1.4 0.026 14.7 1.4 1.4 1 0 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal Interfer-bind PF09294.8 NM_013563.4_3 - 0.27 11.5 2.9 0.54 10.5 0.3 2.4 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III Mito_carr PF00153.25 NM_001317241.1_1 - 4.8e-14 51.9 0.1 5.6e-09 35.7 0.0 3.1 3 0 0 3 3 3 2 Mitochondrial carrier protein Myosin_tail_1 PF01576.17 NM_026599.5_2 - 9.1e-45 152.8 175.9 2.2e-34 118.4 55.5 2.1 1 1 1 2 2 2 2 Myosin tail 7tm_4 PF13853.4 NM_146303.1_1 - 1.3e-52 179.1 23.5 1.6e-52 178.9 23.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146303.1_1 - 5.8e-20 71.5 24.9 1.1e-19 70.7 24.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146303.1_1 - 0.0036 16.6 25.6 0.0095 15.2 25.6 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF3402 PF11882.6 NM_001037740.1_3 - 6.3e-77 259.5 17.5 4.6e-34 118.2 3.1 4.1 1 1 3 4 4 4 4 Domain of unknown function (DUF3402) N1221 PF07923.11 NM_001037740.1_3 - 1.3e-52 178.6 0.1 2e-52 178.1 0.1 1.2 1 0 0 1 1 1 1 N1221-like protein LRR_8 PF13855.4 NM_001290758.1_1 - 1.2e-69 229.8 102.7 9.3e-12 44.4 3.2 14.6 11 3 3 14 14 14 13 Leucine rich repeat LRR_4 PF12799.5 NM_001290758.1_1 - 1e-35 120.9 97.8 6.5e-06 26.2 1.7 16.2 10 5 7 18 18 18 12 Leucine Rich repeats (2 copies) TIR PF01582.18 NM_001290758.1_1 - 3e-14 53.1 0.6 4.7e-14 52.4 0.6 1.3 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.4 NM_001290758.1_1 - 2.3e-11 43.6 15.2 0.0013 18.6 0.2 6.9 4 2 3 7 7 7 3 Leucine rich repeats (6 copies) LRR_1 PF00560.31 NM_001290758.1_1 - 5.3e-10 38.2 82.1 0.16 12.4 0.1 21.4 20 6 2 22 22 22 6 Leucine Rich Repeat LRR_9 PF14580.4 NM_001290758.1_1 - 2.2e-09 36.9 43.1 0.0017 17.7 4.4 7.3 4 3 2 6 6 6 5 Leucine-rich repeat LRR_6 PF13516.4 NM_001290758.1_1 - 1e-05 25.0 64.4 0.46 10.5 0.3 16.7 17 0 0 17 17 17 4 Leucine Rich repeat TIR_2 PF13676.4 NM_001290758.1_1 - 0.00059 20.0 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 TIR domain LRRNT PF01462.16 NM_001290758.1_1 - 0.07 12.7 2.3 1.1 8.8 0.0 4.1 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain RPA_interact_N PF14766.4 NM_001252413.1_2 - 4.3e-18 64.6 2.0 4.3e-18 64.6 2.0 2.0 2 0 0 2 2 2 1 Replication protein A interacting N-terminal RPA_interact_M PF14767.4 NM_001252413.1_2 - 2.1e-11 44.1 10.0 3.3e-11 43.5 10.0 1.3 1 0 0 1 1 1 1 Replication protein A interacting middle RPA_interact_C PF14768.4 NM_001252413.1_2 - 0.0004 20.8 2.3 0.00095 19.6 2.3 1.6 1 0 0 1 1 1 1 Replication protein A interacting C-terminal 7tm_4 PF13853.4 NM_146738.1_1 - 1.1e-53 182.7 21.4 1.3e-53 182.4 21.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146738.1_1 - 7e-20 71.2 24.0 1.6e-19 70.0 24.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FAT PF02259.21 NM_001081362.1_1 - 8.9e-67 225.6 9.3 2.2e-66 224.3 9.3 1.7 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.25 NM_001081362.1_1 - 1.8e-19 70.4 0.0 4.7e-19 69.0 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.18 NM_001081362.1_1 - 2.2e-05 24.0 0.1 9.1e-05 22.1 0.1 2.2 1 0 0 1 1 1 1 FATC domain DEC-1_N PF04625.11 NM_001081362.1_1 - 0.00012 21.1 4.4 0.00024 20.1 4.4 1.4 1 0 0 1 1 1 1 DEC-1 protein, N-terminal region HEAT_EZ PF13513.4 NM_001081362.1_1 - 0.031 14.6 2.4 0.47 10.8 0.2 4.3 4 0 0 4 4 3 0 HEAT-like repeat BP28CT PF08146.10 NM_001081362.1_1 - 0.037 13.9 10.9 0.93 9.4 0.2 5.9 5 0 0 5 5 5 0 BP28CT (NUC211) domain BALF1 PF06861.9 NM_001081362.1_1 - 0.045 13.2 0.0 0.12 11.8 0.0 1.8 1 0 0 1 1 1 0 BALF1 protein DUF3361 PF11841.6 NM_001081362.1_1 - 0.27 11.0 2.7 0.87 9.4 0.3 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) TPR_2 PF07719.15 NM_001081362.1_1 - 1 9.5 5.3 5.6 7.2 0.8 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001081362.1_1 - 5.5 7.3 5.1 29 5.1 0.3 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat FAP PF07174.9 NM_001081362.1_1 - 7.6 5.8 17.6 14 4.9 17.6 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) LRR_8 PF13855.4 NM_177250.2_1 - 6.4e-51 169.8 17.6 2.6e-15 55.8 3.0 6.3 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 NM_177250.2_1 - 3.9e-16 58.7 18.5 9.9e-05 22.5 0.4 7.6 4 1 6 10 10 10 6 Leucine Rich repeats (2 copies) I-set PF07679.14 NM_177250.2_1 - 2.9e-12 46.3 0.0 4.8e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_177250.2_1 - 5.2e-11 42.9 0.0 9.3e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.4 NM_177250.2_1 - 6.7e-09 35.7 0.0 0.0001 22.1 0.0 3.0 1 1 1 3 3 3 3 Leucine rich repeats (6 copies) ig PF00047.23 NM_177250.2_1 - 4.8e-06 26.5 0.0 1.4e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.4 NM_177250.2_1 - 0.0002 20.7 1.3 0.19 11.1 0.0 3.4 2 2 2 4 4 4 2 Leucine-rich repeat LRR_1 PF00560.31 NM_177250.2_1 - 0.00021 21.2 27.6 0.13 12.7 0.0 10.3 13 1 0 13 13 11 2 Leucine Rich Repeat Ig_2 PF13895.4 NM_177250.2_1 - 0.00022 21.4 0.0 0.00047 20.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 NM_177250.2_1 - 0.00089 19.3 0.0 0.036 14.1 0.0 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRRNT PF01462.16 NM_177250.2_1 - 0.002 17.6 2.7 0.0091 15.5 2.7 2.3 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain SET PF00856.26 NM_026796.1_1 - 6.7e-14 52.5 0.1 1.5e-13 51.4 0.0 1.6 2 0 0 2 2 2 1 SET domain zf-MYND PF01753.16 NM_026796.1_1 - 7.6e-10 38.6 14.8 7.6e-10 38.6 14.8 2.1 2 0 0 2 2 2 1 MYND finger TPR_12 PF13424.4 NM_026796.1_1 - 9.4e-05 22.5 0.0 0.0071 16.5 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.4 NM_026796.1_1 - 0.0042 17.1 1.9 0.0058 16.6 0.7 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.4 NM_026796.1_1 - 0.005 16.6 0.0 0.017 14.9 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 NM_026796.1_1 - 0.014 15.3 1.7 0.98 9.6 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat RPN7 PF10602.7 NM_026796.1_1 - 0.13 11.8 0.6 1.9 8.0 0.0 2.6 2 1 1 3 3 3 0 26S proteasome subunit RPN7 Syja_N PF02383.16 NM_011523.2_2 - 1.3e-65 221.6 0.0 1.9e-65 221.1 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain DUF1866 PF08952.9 NM_011523.2_2 - 6.7e-60 201.0 0.1 1.2e-59 200.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.21 NM_011523.2_2 - 9.5e-08 32.2 0.0 3.5e-07 30.3 0.0 2.0 1 1 1 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DMRT-like PF15791.3 NM_027732.2_1 - 1.1e-51 174.2 6.8 1.1e-51 174.2 6.8 2.5 3 0 0 3 3 3 1 Doublesex-and mab-3-related transcription factor C1 and C2 DM PF00751.16 NM_027732.2_1 - 2.7e-20 71.8 10.2 4.6e-20 71.1 10.2 1.4 1 0 0 1 1 1 1 DM DNA binding domain zf-C2H2 PF00096.24 NM_024467.3_1 - 1.1e-50 167.2 140.4 6.8e-06 26.1 0.9 17.4 18 0 0 18 18 18 14 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_024467.3_1 - 3.9e-49 162.9 134.7 2.8e-11 43.2 1.1 16.9 16 0 0 16 16 16 14 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_024467.3_1 - 2.3e-32 108.7 132.3 0.0035 17.9 0.8 17.2 18 0 0 18 18 18 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_024467.3_1 - 9.1e-21 73.5 78.6 0.0018 18.4 1.4 15.2 16 0 0 16 16 16 11 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_024467.3_1 - 3.5e-13 49.4 87.7 0.017 15.3 0.2 14.6 14 0 0 14 14 14 9 Zinc-finger of C2H2 type zf-Di19 PF05605.10 NM_024467.3_1 - 6.1e-06 26.3 88.7 0.0037 17.4 3.3 10.2 6 3 3 10 10 10 7 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 NM_024467.3_1 - 0.004 16.9 0.3 0.004 16.9 0.3 15.4 16 0 0 16 16 16 7 C2H2-type zinc finger BolA PF01722.16 NM_024467.3_1 - 1.5 9.0 28.6 18 5.6 0.1 7.8 5 3 3 9 9 9 0 BolA-like protein zf-C2H2_9 PF16293.3 NM_024467.3_1 - 2 8.2 31.3 5.8 6.7 0.1 8.8 8 0 0 8 8 8 0 C2H2 type zinc-finger (1 copy) IQ PF00612.25 NM_029408.2_2 - 3.1e-05 23.2 0.6 9.2e-05 21.8 0.6 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif BssS PF13991.4 NM_029408.2_2 - 0.54 10.2 2.8 1 9.3 0.0 2.7 3 0 0 3 3 3 0 BssS protein family Wound_ind PF08186.9 NM_029408.2_2 - 4.5 7.7 8.6 11 6.5 8.6 1.6 1 0 0 1 1 1 0 Wound-inducible basic protein family Nucleoporin_FG2 PF15967.3 NM_029408.2_2 - 6.1 5.1 4.8 9.8 4.4 4.8 1.3 1 0 0 1 1 1 0 Nucleoporin FG repeated region LRR_9 PF14580.4 NM_001163579.1_3 - 2.2e-10 40.2 2.1 3.6e-07 29.7 1.9 2.8 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.4 NM_001163579.1_3 - 1.3e-09 37.5 20.7 2.4e-05 23.9 3.3 4.2 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_001163579.1_3 - 1.1e-08 35.1 31.7 3.7e-05 23.8 5.0 5.7 4 1 2 7 7 7 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 NM_001163579.1_3 - 0.24 11.4 18.9 0.67 10.0 0.7 4.7 3 1 1 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.31 NM_001163579.1_3 - 2 9.1 17.9 5.2 7.8 2.4 6.3 5 1 0 5 5 5 0 Leucine Rich Repeat Archease PF01951.14 NM_001163579.1_3 - 3.3 7.8 7.3 3.3 7.8 5.1 2.1 1 1 0 1 1 1 0 Archease protein family (MTH1598/TM1083) ArfGap PF01412.16 NM_172133.1_1 - 6e-32 110.0 0.0 1e-31 109.3 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.27 NM_172133.1_1 - 1.1e-20 73.9 0.2 3.1e-09 37.1 0.0 2.5 2 0 0 2 2 2 2 PH domain PH_11 PF15413.4 NM_172133.1_1 - 1.1e-06 28.8 3.7 0.034 14.4 0.2 4.2 3 2 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.4 NM_172133.1_1 - 3e-06 27.3 0.3 0.13 12.4 0.0 2.8 3 0 0 3 3 3 2 Pleckstrin homology domain Mcp5_PH PF12814.5 NM_172133.1_1 - 0.0072 16.3 0.0 0.03 14.3 0.0 2.0 1 1 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology CCDC92 PF14916.4 NM_198605.3_1 - 0.11 12.1 0.2 0.21 11.2 0.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain of unknown function MARVEL PF01284.21 NM_028052.4_2 - 3.7e-42 143.6 7.4 5.8e-42 143.0 7.4 1.3 1 0 0 1 1 1 1 Membrane-associating domain Tim17 PF02466.17 NM_021534.3_3 - 6.9e-11 42.3 0.7 1.2e-10 41.5 0.7 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family WD40 PF00400.30 NM_001081191.1_1 - 5.3e-60 197.8 87.6 2.2e-05 25.0 0.2 26.2 29 0 0 29 29 29 15 WD domain, G-beta repeat HELP PF03451.12 NM_001081191.1_1 - 4.7e-55 183.2 0.5 1.7e-18 66.1 0.1 3.4 3 0 0 3 3 3 3 HELP motif ANAPC4_WD40 PF12894.5 NM_001081191.1_1 - 7.4e-33 112.6 5.2 1.8e-07 31.2 0.0 12.3 8 3 4 13 13 13 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 NM_001081191.1_1 - 2e-05 23.6 1.1 0.23 10.3 0.0 5.3 4 3 2 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.14 NM_001081191.1_1 - 0.014 13.8 8.8 1 7.7 0.0 5.5 7 1 1 8 8 8 0 Cytochrome D1 heme domain RGS PF00615.17 NM_019958.4_1 - 8.3e-35 119.5 1.5 2.1e-34 118.2 1.5 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF2681 PF10883.6 NM_019958.4_1 - 2.9 8.2 10.5 6.1 7.2 10.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) FBA PF04300.11 NM_001310687.1_2 - 2.6e-44 151.1 0.0 3.9e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 F-box associated region F-box-like PF12937.5 NM_001310687.1_2 - 9.6e-10 38.1 1.9 1.9e-09 37.1 1.9 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_001310687.1_2 - 8.8e-09 34.9 1.1 1.8e-08 33.9 1.1 1.4 1 0 0 1 1 1 1 F-box domain RhlB PF12300.6 NM_001025605.1_2 - 0.16 12.1 19.6 0.23 11.5 19.6 1.1 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Defensin_beta_2 PF13841.4 NM_176950.3_1 - 4e-06 27.1 12.1 7.2e-06 26.3 12.1 1.5 1 0 0 1 1 1 1 Beta defensin Carn_acyltransf PF00755.18 NM_009948.2_1 - 8.9e-194 645.2 0.0 1e-193 645.0 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 NM_009948.2_1 - 1.5e-26 91.9 0.0 3.4e-26 90.8 0.0 1.6 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus DUF3128 PF11326.6 NM_009948.2_1 - 0.00075 19.6 0.3 0.012 15.8 0.6 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3128) Topoisom_bac PF01131.18 NM_009410.2_1 - 1.2e-112 376.9 0.0 3.2e-112 375.4 0.0 1.6 2 0 0 2 2 2 1 DNA topoisomerase zf-GRF PF06839.10 NM_009410.2_1 - 8.4e-39 131.3 19.9 2.4e-20 72.2 4.3 3.1 3 0 0 3 3 3 2 GRF zinc finger Toprim PF01751.20 NM_009410.2_1 - 1.1e-18 67.2 0.0 2.1e-17 63.1 0.0 2.3 2 0 0 2 2 2 1 Toprim domain zf-C4_Topoisom PF01396.17 NM_009410.2_1 - 6.7e-13 48.1 1.9 6.7e-13 48.1 1.9 3.3 4 0 0 4 4 4 1 Topoisomerase DNA binding C4 zinc finger zf-C2H2_10 PF16588.3 NM_009410.2_1 - 0.00021 20.8 2.4 0.0007 19.1 2.4 1.9 1 0 0 1 1 1 1 C2H2 zinc-finger 7tm_4 PF13853.4 NM_001011737.2_1 - 9.1e-50 169.8 16.6 1.2e-49 169.4 16.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011737.2_1 - 7.9e-24 84.2 21.8 1.7e-23 83.1 21.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011737.2_1 - 6.1e-10 38.8 17.2 9.7e-10 38.1 17.2 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx BolA PF01722.16 NM_175277.4_3 - 3.6e-11 43.0 0.0 6.7e-11 42.2 0.1 1.4 1 1 0 1 1 1 1 BolA-like protein RNA_binding PF01877.15 NM_175277.4_3 - 0.053 13.7 0.1 0.082 13.1 0.1 1.2 1 0 0 1 1 1 0 RNA binding Meis_PKNOX_N PF16493.3 NM_010825.3_3 - 6.1e-45 151.4 0.2 1.1e-44 150.6 0.2 1.4 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.9 NM_010825.3_3 - 3.8e-20 71.4 1.0 7.1e-20 70.5 1.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 NM_010825.3_3 - 1.1e-07 31.4 0.4 2.4e-07 30.3 0.4 1.5 1 0 0 1 1 1 1 Homeobox domain Ig_3 PF13927.4 NM_023061.2_3 - 5.2e-36 123.0 3.0 1.8e-09 37.9 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 NM_023061.2_3 - 3.4e-25 88.1 0.7 1.3e-06 28.5 0.0 4.9 5 0 0 5 5 5 4 Immunoglobulin domain ig PF00047.23 NM_023061.2_3 - 2.3e-24 85.2 2.1 3.2e-07 30.3 0.0 6.0 5 1 0 5 5 5 4 Immunoglobulin domain C2-set_2 PF08205.10 NM_023061.2_3 - 5.3e-24 84.0 11.2 2.1e-18 66.0 0.0 5.4 5 1 0 5 5 5 3 CD80-like C2-set immunoglobulin domain I-set PF07679.14 NM_023061.2_3 - 1.8e-22 79.0 1.9 2.1e-05 24.4 1.3 6.9 5 2 0 5 5 5 4 Immunoglobulin I-set domain V-set PF07686.15 NM_023061.2_3 - 4.3e-18 65.3 2.8 3.8e-06 26.9 0.0 5.8 5 2 2 7 7 7 4 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_023061.2_3 - 1.9e-05 24.9 1.5 1.6 9.1 0.0 3.8 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 NM_023061.2_3 - 0.0011 19.2 0.1 4.7 7.5 0.0 3.8 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain DUF4366 PF14283.4 NM_023061.2_3 - 0.078 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Pkinase PF00069.23 NM_011938.4_2 - 1.1e-68 231.3 0.0 1.4e-68 230.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_011938.4_2 - 2.3e-35 122.0 0.0 3e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 NM_011938.4_2 - 1.1e-18 67.5 0.1 2.9e-18 66.1 0.0 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain Kinase-like PF14531.4 NM_011938.4_2 - 0.00012 21.4 0.0 0.00019 20.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Filament PF00038.19 NM_133730.1_3 - 1.2e-97 327.1 18.4 1.6e-97 326.7 18.4 1.2 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 NM_133730.1_3 - 0.0072 16.3 2.0 0.0072 16.3 2.0 4.1 4 1 0 4 4 4 2 TPR/MLP1/MLP2-like protein Phage_Mu_Gam PF07352.10 NM_133730.1_3 - 0.013 15.2 1.2 0.013 15.2 1.2 3.9 3 1 0 4 4 4 0 Bacteriophage Mu Gam like protein V_ATPase_I PF01496.17 NM_133730.1_3 - 1.3 6.7 9.3 0.17 9.6 4.7 1.7 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Reo_sigmaC PF04582.10 NM_133730.1_3 - 1.7 7.8 10.0 0.23 10.7 3.1 2.4 2 1 0 3 3 3 0 Reovirus sigma C capsid protein Bacillus_HBL PF05791.9 NM_133730.1_3 - 7.7 6.1 13.5 0.12 11.9 2.8 3.1 3 1 1 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) PX PF00787.22 NM_172468.2_1 - 5.7e-22 77.7 2.2 1.1e-21 76.8 2.2 1.4 1 0 0 1 1 1 1 PX domain BAR PF03114.16 NM_172468.2_1 - 9.4e-07 28.6 0.1 1.4e-06 28.0 0.1 1.2 1 0 0 1 1 1 1 BAR domain Vps5 PF09325.8 NM_172468.2_1 - 4.6e-05 22.9 0.1 0.084 12.3 0.0 2.2 1 1 1 2 2 2 2 Vps5 C terminal like Bromodomain PF00439.23 NM_145076.4_1 - 2e-20 72.5 0.2 3.7e-20 71.6 0.2 1.5 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.22 NM_145076.4_1 - 2.4e-10 40.3 22.1 2.9e-09 36.8 7.3 5.0 5 0 0 5 5 5 2 B-box zinc finger PHD PF00628.27 NM_145076.4_1 - 2.6e-08 33.5 10.1 2.6e-08 33.5 10.1 4.9 5 0 0 5 5 5 1 PHD-finger zf-RING_UBOX PF13445.4 NM_145076.4_1 - 8.9e-05 22.3 4.5 8.9e-05 22.3 4.5 3.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.4 NM_145076.4_1 - 0.0023 17.7 8.8 0.0023 17.7 8.8 4.9 4 2 1 5 5 5 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_145076.4_1 - 0.003 17.6 2.8 0.003 17.6 2.8 6.1 6 0 0 6 6 6 1 Ring finger domain zf-C3HC4 PF00097.23 NM_145076.4_1 - 0.0067 16.2 4.1 0.0067 16.2 4.1 4.3 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) DUF4649 PF15507.4 NM_145076.4_1 - 0.042 13.7 0.3 0.21 11.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4649) Imm68 PF15583.4 NM_145076.4_1 - 0.96 9.5 3.0 1.7 8.7 3.0 1.3 1 0 0 1 1 1 0 Immunity protein 68 TP53IP5 PF15331.4 NM_001271575.1_3 - 5.5e-94 314.2 16.5 8e-94 313.7 16.5 1.2 1 0 0 1 1 1 1 Cellular tumour antigen p53-inducible 5 Cas_Csn2 PF09711.8 NM_001271575.1_3 - 0.038 13.5 1.4 0.043 13.3 0.3 1.6 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csn2) zf-H2C2_2 PF13465.4 NM_133204.2_2 - 8e-26 89.2 39.9 9.6e-08 32.0 0.3 6.5 6 0 0 6 6 6 5 Zinc-finger double domain SCAN PF02023.15 NM_133204.2_2 - 1.8e-23 82.1 0.5 4.3e-23 80.8 0.5 1.7 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 NM_133204.2_2 - 2.8e-19 68.3 38.3 1.3e-05 25.2 3.0 5.8 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_133204.2_2 - 2.4e-11 43.3 42.6 0.00041 20.8 2.0 6.0 6 0 0 6 6 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_133204.2_2 - 1.6e-07 31.3 15.1 0.018 15.2 0.8 4.7 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_133204.2_2 - 0.013 15.3 1.7 0.013 15.3 1.7 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger zf-met PF12874.5 NM_133204.2_2 - 0.25 11.6 32.0 0.79 10.1 1.1 5.6 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-AN1 PF01428.14 NM_133204.2_2 - 1.1 9.4 23.5 0.12 12.4 1.5 5.1 5 0 0 5 5 5 0 AN1-like Zinc finger zf-trcl PF13451.4 NM_133204.2_2 - 1.2 9.0 19.1 1.5 8.6 1.3 4.8 4 1 0 4 4 4 0 Probable zinc-ribbon domain DUF3268 PF11672.6 NM_133204.2_2 - 1.3 9.2 8.5 7.7 6.7 0.6 2.5 2 0 0 2 2 2 0 zinc-finger-containing domain ADK_lid PF05191.12 NM_133204.2_2 - 3.2 7.7 10.8 20 5.2 0.1 3.7 2 1 2 4 4 4 0 Adenylate kinase, active site lid DUF4428 PF14471.4 NM_133204.2_2 - 3.4 7.5 11.4 2 8.3 1.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) C1_4 PF07975.10 NM_133204.2_2 - 6.3 7.0 23.7 5.7 7.2 4.0 4.1 1 1 2 4 4 4 0 TFIIH C1-like domain zf-LYAR PF08790.9 NM_133204.2_2 - 7.2 6.5 22.5 2.5 8.0 0.3 5.0 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger Trypsin PF00089.24 NM_010640.2_2 - 5.6e-73 245.3 0.1 6.4e-73 245.1 0.1 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 NM_010640.2_2 - 9e-07 29.1 0.0 0.00016 21.9 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_010640.2_2 - 1.2e-05 26.1 0.0 2.2e-05 25.3 0.0 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.13 NM_010640.2_2 - 0.0059 16.1 0.0 1.2 8.5 0.0 2.1 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 Pkinase_Tyr PF07714.15 NM_001130409.1_3 - 2.3e-93 312.1 0.0 3.4e-93 311.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001130409.1_3 - 7.4e-46 156.5 0.0 1.1e-45 155.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 NM_001130409.1_3 - 3.9e-11 43.2 0.5 1.4e-10 41.4 0.3 2.0 2 0 0 2 2 2 1 FERM central domain Kinase-like PF14531.4 NM_001130409.1_3 - 0.0066 15.7 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like p450 PF00067.20 NM_001163472.1_1 - 1.6e-136 455.6 0.0 1.9e-136 455.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Lebercilin PF15619.4 NM_029434.3_3 - 2.1e-63 213.3 45.6 2.9e-63 212.9 45.6 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Tantalus PF15386.4 NM_029434.3_3 - 0.13 12.3 3.7 0.32 11.0 3.7 1.7 1 0 0 1 1 1 0 Drosophila Tantalus-like Sec8_exocyst PF04048.12 NM_029434.3_3 - 4.7 7.0 13.6 0.042 13.6 3.1 2.7 1 1 3 4 4 4 0 Sec8 exocyst complex component specific domain RRM_1 PF00076.20 NM_198102.2_3 - 1.5e-19 69.4 0.1 3.8e-19 68.1 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Apt1 PF10351.7 NM_198102.2_3 - 0.14 10.9 11.6 0.18 10.5 11.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.15 NM_198102.2_3 - 2.7 6.5 8.4 3.9 6.0 8.4 1.1 1 0 0 1 1 1 0 Presenilin DUF1777 PF08648.10 NM_198102.2_3 - 7.8 6.6 46.8 0.45 10.6 1.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) PH PF00169.27 NM_001305190.1_1 - 1.7e-18 66.9 0.4 4.6e-18 65.5 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.4 NM_001305190.1_1 - 4.1e-08 33.5 0.0 9.7e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 NM_001305190.1_1 - 3.5e-05 23.9 0.0 0.02 15.0 0.0 2.5 1 1 1 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.4 NM_001305190.1_1 - 0.064 13.5 0.7 0.19 12.0 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain OGG_N PF07934.10 NM_001305190.1_1 - 0.097 12.6 1.3 0.26 11.3 1.3 1.7 1 0 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain ABC1 PF03109.14 NM_001277297.1_1 - 1.5e-39 134.7 0.1 2.2e-39 134.1 0.1 1.3 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.23 NM_001277297.1_1 - 1.6e-06 27.5 0.1 0.00014 21.2 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.21 NM_001277297.1_1 - 0.00053 19.9 0.1 0.15 11.8 0.1 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family Keratin_B2_2 PF13885.4 NM_029613.1_1 - 2.2e-26 91.4 286.8 1.7e-11 43.7 68.0 5.8 2 1 4 6 6 6 4 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_029613.1_1 - 7.7e-07 29.1 181.5 0.0006 19.7 62.3 4.2 1 1 1 2 2 2 2 Keratin, high sulfur B2 protein Rad51 PF08423.9 NM_010059.3_2 - 7.3e-109 362.8 0.0 9.5e-109 362.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.19 NM_010059.3_2 - 2.9e-10 39.9 0.0 4.2e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.11 NM_010059.3_2 - 1.4e-05 24.4 0.1 2.4e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.4 NM_010059.3_2 - 3.5e-05 23.3 0.0 6.2e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.4 NM_010059.3_2 - 0.00011 22.6 0.4 0.00025 21.5 0.4 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF128 PF01995.14 NM_010059.3_2 - 0.015 14.5 0.1 0.026 13.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF128 DnaB_C PF03796.13 NM_010059.3_2 - 0.12 11.5 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain PDEase_I PF00233.17 NM_001008548.4_1 - 6.7e-78 261.6 7.2 1.1e-77 260.8 7.2 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 NM_001008548.4_1 - 1.4e-26 93.5 1.3 1.3e-15 58.0 0.0 3.5 3 0 0 3 3 3 3 GAF domain GAF_2 PF13185.4 NM_001008548.4_1 - 4.4e-22 78.7 0.2 6.2e-09 36.2 0.0 3.6 3 0 0 3 3 3 3 GAF domain GAF_3 PF13492.4 NM_001008548.4_1 - 1.6e-10 41.3 0.1 3.2e-06 27.3 0.0 3.1 3 0 0 3 3 3 2 GAF domain DUF3819 PF12842.5 NM_001008548.4_1 - 0.27 11.0 1.7 17 5.2 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3819) NTF2 PF02136.18 NM_001080796.2_1 - 5e-32 110.8 0.1 7.6e-32 110.2 0.1 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.20 NM_001080796.2_1 - 2.9e-13 49.3 0.1 5.7e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001080796.2_1 - 3.1e-05 23.9 0.0 6.2e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif tRNA-synt_2c PF01411.17 NM_146217.4_3 - 3.5e-226 751.9 0.0 4.8e-226 751.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.12 NM_146217.4_3 - 3.7e-17 62.0 0.1 7.9e-17 60.9 0.1 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.17 NM_146217.4_3 - 2.1e-12 46.8 0.0 7.7e-12 44.9 0.0 2.0 1 0 0 1 1 1 1 DHHA1 domain BST2 PF16716.3 NM_146217.4_3 - 0.3 11.5 1.7 0.56 10.7 0.7 1.9 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 tRNA-synt_1 PF00133.20 NM_134137.2_1 - 3.3e-40 137.8 0.0 1.2e-26 93.1 0.0 2.5 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.11 NM_134137.2_1 - 3.4e-18 65.9 0.0 9.5e-18 64.5 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.9 NM_134137.2_1 - 9.3e-18 64.0 0.1 7.1e-09 34.8 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.17 NM_134137.2_1 - 1.2e-06 28.0 0.0 2.3e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.16 NM_134137.2_1 - 0.019 13.8 0.0 0.051 12.3 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class I (K) Abhydrolase_1 PF00561.18 NM_134130.1_3 - 1.4e-11 44.4 0.0 7.8e-09 35.4 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_134130.1_3 - 3.7e-08 34.1 0.0 5.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 NM_134130.1_3 - 5.4e-06 25.7 0.0 8.3e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 7tm_1 PF00001.19 NM_175669.3_3 - 8.6e-21 74.2 17.7 8.6e-21 74.2 17.7 2.3 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) COX14 PF14880.4 NM_175669.3_3 - 0.24 11.1 1.8 1.9 8.2 0.2 2.9 2 0 0 2 2 2 0 Cytochrome oxidase c assembly SpoIIE PF07228.10 NM_177242.4_2 - 1.5e-13 50.9 0.0 2.4e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.4 NM_177242.4_2 - 0.00026 20.6 0.2 0.00098 18.7 0.2 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.19 NM_177242.4_2 - 0.0024 17.4 0.0 0.077 12.5 0.0 2.1 2 0 0 2 2 2 1 Protein phosphatase 2C Actin PF00022.17 NM_146243.2_1 - 3e-116 388.2 0.0 1.1e-115 386.4 0.0 1.7 1 1 0 1 1 1 1 Actin FERM_C PF09380.8 NM_145506.4_3 - 4.9e-21 74.8 0.0 8.5e-21 74.0 0.0 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 NM_145506.4_3 - 4.3e-19 68.9 0.3 9.6e-19 67.8 0.3 1.6 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.8 NM_145506.4_3 - 4.3e-14 52.1 0.1 1e-13 50.9 0.1 1.6 1 0 0 1 1 1 1 FERM N-terminal domain FA PF08736.9 NM_145506.4_3 - 1.2e-13 50.7 13.0 2.4e-13 49.8 13.0 1.5 1 0 0 1 1 1 1 FERM adjacent (FA) ApoL PF05461.9 NM_145506.4_3 - 0.024 13.9 0.6 0.034 13.4 0.6 1.1 1 0 0 1 1 1 0 Apolipoprotein L ABC_membrane PF00664.21 NM_009592.1_2 - 1.6e-36 126.3 11.2 2.3e-36 125.7 11.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 NM_009592.1_2 - 1.1e-33 116.5 0.0 1.9e-33 115.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 NM_009592.1_2 - 0.00016 21.0 0.1 0.018 14.3 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 NM_009592.1_2 - 0.004 17.4 0.0 0.0079 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.4 NM_009592.1_2 - 0.0054 16.3 0.2 0.014 15.0 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF87 PF01935.15 NM_009592.1_2 - 0.034 14.0 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 Amidohydro_1 PF01979.18 NM_001136086.2_1 - 7e-39 134.0 0.1 8.8e-39 133.6 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 NM_001136086.2_1 - 4.4e-14 52.7 0.1 4.5e-07 29.6 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Prokineticin PF06607.9 NM_001037539.2_1 - 1.7e-46 156.3 5.9 2.7e-46 155.7 5.9 1.3 1 0 0 1 1 1 1 Prokineticin THAP PF05485.10 NM_026909.2_2 - 8.9e-15 55.3 0.1 2.3e-14 54.0 0.1 1.7 1 0 0 1 1 1 1 THAP domain Tho2 PF11262.6 NM_026909.2_2 - 0.76 8.8 3.8 1 8.4 3.8 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 HECT PF00632.23 NM_029438.3_3 - 8.8e-102 340.6 0.0 1.1e-101 340.2 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 NM_029438.3_3 - 1.6e-16 59.8 3.4 4.4e-08 32.8 0.1 2.9 2 0 0 2 2 2 2 WW domain C2 PF00168.28 NM_029438.3_3 - 9.4e-16 57.8 0.0 1.8e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 C2 domain HPS3_N PF14761.4 NM_029438.3_3 - 0.11 11.9 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 PTRF_SDPR PF15237.4 NM_001081353.1_1 - 0.089 12.3 1.1 0.1 12.0 0.0 1.5 2 0 0 2 2 2 0 PTRF/SDPR family Sacchrp_dh_C PF16653.3 NM_013930.4_2 - 3e-85 286.3 0.0 4.7e-85 285.7 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain AlaDh_PNT_N PF05222.13 NM_013930.4_2 - 1.4e-25 90.1 0.1 3e-25 89.0 0.0 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain Sacchrp_dh_NADP PF03435.16 NM_013930.4_2 - 1.1e-23 83.7 0.0 2e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.19 NM_013930.4_2 - 5e-06 25.8 0.0 0.00048 19.4 0.0 3.2 3 1 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain DUF2325 PF10087.7 NM_013930.4_2 - 0.029 14.4 0.0 0.061 13.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) Shikimate_DH PF01488.18 NM_013930.4_2 - 0.11 12.4 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase PUF PF00806.17 NM_001160222.1_2 - 1.1e-71 232.5 10.0 2e-09 36.5 0.0 9.1 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.9 NM_001160222.1_2 - 0.066 13.4 1.0 15 5.7 0.0 3.6 1 1 3 4 4 4 0 CPL (NUC119) domain PC4 PF02229.14 NM_001160222.1_2 - 0.13 11.8 0.3 0.29 10.7 0.3 1.5 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) COesterase PF00135.26 NM_009738.3_2 - 3.6e-173 577.0 0.0 4.3e-173 576.8 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.8 NM_009738.3_2 - 1.3e-21 75.8 8.0 3.2e-21 74.6 8.0 1.7 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.11 NM_009738.3_2 - 4.1e-05 23.4 0.0 7.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ion_trans PF00520.29 NM_013838.2_3 - 2.7e-35 121.6 17.0 4.2e-35 121.0 17.0 1.2 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.9 NM_013838.2_3 - 1e-26 92.7 1.0 2.1e-26 91.8 1.0 1.5 1 0 0 1 1 1 1 Transient receptor ion channel II PKD_channel PF08016.10 NM_013838.2_3 - 4.7e-14 51.8 14.0 7.6e-14 51.1 14.0 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.5 NM_013838.2_3 - 2.6e-11 43.8 0.5 1.3e-07 32.0 0.4 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_013838.2_3 - 7.8e-06 26.0 1.4 0.062 13.6 0.2 4.4 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_013838.2_3 - 1.5e-05 25.3 0.4 0.00045 20.6 0.1 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_013838.2_3 - 0.0004 20.5 2.9 10 6.9 0.0 5.0 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.28 NM_013838.2_3 - 0.017 15.5 1.1 14 6.2 0.0 3.6 3 0 0 3 3 3 0 Ankyrin repeat ING PF12998.5 NM_013838.2_3 - 1.3 9.5 10.4 0.13 12.7 1.5 3.0 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Baculo_11_kDa PF06143.9 NM_013838.2_3 - 9.7 5.7 6.9 2.1 7.8 0.8 2.5 2 0 0 2 2 2 0 Baculovirus 11 kDa family Lectin_C PF00059.19 NM_144943.3_2 - 6.9e-23 81.3 2.4 1.1e-22 80.7 2.4 1.3 1 0 0 1 1 1 1 Lectin C-type domain Phage_GP20 PF06810.9 NM_144943.3_2 - 0.0089 15.7 1.6 0.017 14.8 1.6 1.4 1 0 0 1 1 1 1 Phage minor structural protein GP20 IncA PF04156.12 NM_144943.3_2 - 0.0093 15.6 0.1 0.021 14.5 0.1 1.5 1 0 0 1 1 1 1 IncA protein NPV_P10 PF05531.10 NM_144943.3_2 - 0.021 15.1 1.9 0.021 15.1 1.9 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein FPP PF05911.9 NM_144943.3_2 - 0.029 12.5 2.8 0.04 12.0 2.8 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil DUF4225 PF13988.4 NM_144943.3_2 - 0.084 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) Tropomyosin_1 PF12718.5 NM_144943.3_2 - 0.099 12.6 1.9 0.16 11.9 1.9 1.3 1 0 0 1 1 1 0 Tropomyosin like Reo_sigmaC PF04582.10 NM_144943.3_2 - 0.13 11.5 3.9 0.24 10.6 3.9 1.5 1 1 0 1 1 1 0 Reovirus sigma C capsid protein TMF_TATA_bd PF12325.6 NM_144943.3_2 - 0.13 12.4 3.0 0.22 11.6 3.0 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Spectrin PF00435.19 NM_144943.3_2 - 0.23 11.8 1.4 6.6 7.2 0.1 2.3 1 1 0 2 2 2 0 Spectrin repeat Seryl_tRNA_N PF02403.20 NM_144943.3_2 - 0.35 11.0 3.8 1.2 9.3 1.8 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.10 NM_144943.3_2 - 0.51 10.3 2.7 0.97 9.4 0.8 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein CALCOCO1 PF07888.9 NM_144943.3_2 - 0.61 8.5 3.2 0.87 7.9 3.2 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Med9 PF07544.11 NM_144943.3_2 - 1.6 8.7 4.7 11 6.1 1.4 2.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 zf-H2C2_2 PF13465.4 NM_172482.1_3 - 1.2e-79 259.3 126.9 7.1e-09 35.6 3.1 17.8 18 0 0 18 18 18 14 Zinc-finger double domain zf-C2H2 PF00096.24 NM_172482.1_3 - 2.1e-61 201.0 141.5 1.6e-06 28.1 3.7 16.8 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_172482.1_3 - 5.2e-28 95.2 136.7 0.0069 17.0 4.2 17.1 17 0 0 17 17 17 14 C2H2-type zinc finger KRAB PF01352.25 NM_172482.1_3 - 2.5e-22 78.2 0.6 5.6e-22 77.0 0.6 1.7 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 NM_172482.1_3 - 8.7e-12 44.8 64.0 0.035 14.1 1.1 9.9 4 2 6 11 11 11 10 Zinc ribbon domain DUF3268 PF11672.6 NM_172482.1_3 - 0.00059 20.0 45.1 0.62 10.3 0.7 7.9 6 2 0 7 7 7 5 zinc-finger-containing domain DZR PF12773.5 NM_172482.1_3 - 0.0068 16.3 77.7 4.9e+02 0.7 12.5 9.1 4 2 1 5 5 5 0 Double zinc ribbon zinc_ribbon_15 PF17032.3 NM_172482.1_3 - 0.12 13.1 67.6 0.58 10.8 0.7 9.0 2 1 7 9 9 9 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 NM_172482.1_3 - 1.1 9.5 0.0 1.1 9.5 0.0 14.5 16 0 0 16 16 16 0 Zinc-finger double-stranded RNA-binding SMAP PF15477.4 NM_023197.3_1 - 5.4e-10 39.9 0.4 5.4e-10 39.9 0.4 2.5 3 0 0 3 3 3 1 Small acidic protein family Tweety PF04906.11 NM_001001454.4_3 - 9.8e-162 538.1 1.5 1.3e-161 537.7 1.5 1.0 1 0 0 1 1 1 1 Tweety Prominin PF05478.9 NM_001001454.4_3 - 0.38 8.5 6.0 0.73 7.6 1.8 2.3 1 1 1 2 2 2 0 Prominin DUF4131 PF13567.4 NM_001001454.4_3 - 2.6 7.5 19.4 0.05 13.1 3.0 2.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4131) 7tm_1 PF00001.19 NM_007538.3_3 - 1.7e-41 142.1 14.9 2.4e-41 141.6 14.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 NM_007538.3_3 - 2e-07 30.5 13.3 3.9e-07 29.6 13.3 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 NM_007538.3_3 - 5.5e-05 22.9 16.0 0.0011 18.7 16.0 2.2 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 NM_007538.3_3 - 0.0054 15.9 14.2 0.011 15.0 14.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx WBP-1 PF11669.6 NM_007538.3_3 - 0.046 14.2 1.0 0.11 13.0 1.0 1.6 1 0 0 1 1 1 0 WW domain-binding protein 1 Ets PF00178.20 NM_001322265.1_3 - 1.7e-33 114.8 2.7 3e-33 114.0 2.7 1.4 1 0 0 1 1 1 1 Ets-domain Nebulin PF00880.16 NM_008733.4_3 - 2.4e-198 640.6 126.1 9.2e-09 35.0 0.1 41.6 42 0 0 42 42 42 39 Nebulin repeat LIM PF00412.20 NM_008733.4_3 - 6e-09 35.9 9.9 1.9e-08 34.2 9.9 1.9 1 0 0 1 1 1 1 LIM domain c-SKI_SMAD_bind PF08782.8 NM_008733.4_3 - 0.06 13.5 4.3 0.25 11.5 4.3 2.1 1 0 0 1 1 1 0 c-SKI Smad4 binding domain Lectin_C PF00059.19 NM_001204253.1_2 - 3.9e-11 43.5 0.6 3.9e-11 43.5 0.6 1.7 2 0 0 2 2 2 1 Lectin C-type domain NACHT PF05729.10 NM_001243760.2_1 - 4.3e-43 147.0 0.1 4e-42 143.8 0.0 2.4 2 0 0 2 2 2 1 NACHT domain LRR_6 PF13516.4 NM_001243760.2_1 - 2.9e-12 45.5 3.3 0.015 15.2 0.1 5.1 4 1 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.5 NM_001243760.2_1 - 0.00027 21.1 2.4 0.0084 16.4 1.3 3.4 2 1 2 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_001243760.2_1 - 0.0016 18.0 3.3 0.028 14.1 0.1 3.5 1 1 2 3 3 3 2 Leucine rich repeat LRR_9 PF14580.4 NM_001243760.2_1 - 0.017 14.5 0.0 0.04 13.3 0.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.31 NM_001243760.2_1 - 0.12 12.8 0.4 48 4.9 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat G-gamma PF00631.20 NM_001284393.1_2 - 6.4e-13 48.4 0.0 9.9e-13 47.8 0.0 1.3 1 0 0 1 1 1 1 GGL domain Myc-LZ PF02344.13 NM_001284393.1_2 - 0.11 12.5 3.7 0.22 11.5 3.7 1.4 1 0 0 1 1 1 0 Myc leucine zipper domain Bax1-I PF01027.18 NM_001171034.1_2 - 9.5e-41 139.8 19.1 1.3e-40 139.3 19.1 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 7TMR-DISM_7TM PF07695.9 NM_001171034.1_2 - 1.3 8.8 22.7 0.4 10.4 6.1 2.2 1 1 1 2 2 2 0 7TM diverse intracellular signalling zf-C2H2_4 PF13894.4 NM_016889.3_3 - 2.7e-14 52.5 34.7 0.013 16.2 1.5 5.9 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_016889.3_3 - 3.7e-14 52.2 37.3 0.0053 17.0 2.0 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 NM_016889.3_3 - 0.00027 21.0 17.1 0.34 11.1 1.9 5.4 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_016889.3_3 - 0.00097 18.9 32.6 0.77 9.6 0.5 5.6 5 0 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.5 NM_016889.3_3 - 0.082 13.2 18.4 1.1 9.6 0.3 4.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type IATP PF04568.10 NM_016889.3_3 - 0.37 11.1 1.4 1 9.7 1.4 1.7 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP zf-Di19 PF05605.10 NM_016889.3_3 - 3.8 7.7 27.1 0.093 12.9 0.6 4.6 4 1 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Pkinase_Tyr PF07714.15 NM_001289612.1_1 - 1e-91 306.7 0.0 1.2e-91 306.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001289612.1_1 - 4.3e-45 154.0 0.0 6.6e-45 153.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.12 NM_001289612.1_1 - 0.0029 16.9 0.1 0.0048 16.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EPTP PF03736.15 NM_001289612.1_1 - 0.079 12.8 1.2 2.2 8.2 0.1 2.4 2 0 0 2 2 2 0 EPTP domain Inositol_P PF00459.23 NM_018864.6_2 - 2.2e-82 276.5 0.0 3e-82 276.1 0.0 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family NUDIX PF00293.26 NM_153136.4_1 - 2.9e-18 66.0 0.1 5.9e-18 65.1 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain Ig_2 PF13895.4 NM_029025.3_3 - 0.0087 16.3 0.0 0.016 15.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Histone PF00125.22 NM_001085517.2_2 - 5.4e-08 33.2 0.2 8.9e-08 32.5 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 NM_001085517.2_2 - 0.00014 22.0 0.0 0.00019 21.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.4 NM_001085517.2_2 - 0.0067 16.4 0.0 0.011 15.7 0.0 1.3 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-18kDa PF02269.14 NM_001085517.2_2 - 0.0093 15.8 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-S PF15630.4 NM_001085517.2_2 - 0.021 15.1 0.0 0.036 14.3 0.0 1.4 1 0 0 1 1 1 0 CENP-S protein UPF0688 PF15772.3 NM_001163019.1_3 - 6.4e-77 258.8 14.3 7.5e-77 258.6 14.3 1.0 1 0 0 1 1 1 1 UPF0688 family W_rich_C PF07483.9 NM_001167588.1_2 - 0.088 12.8 0.0 0.096 12.7 0.0 1.1 1 0 0 1 1 1 0 Tryptophan-rich Synechocystis species C-terminal domain V-set PF07686.15 NM_027403.4_2 - 2.1e-38 130.7 0.3 3.7e-12 46.2 0.0 5.1 4 1 0 4 4 4 4 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_027403.4_2 - 4.1e-23 81.7 0.4 7.7e-09 35.9 0.1 4.7 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 NM_027403.4_2 - 1.3e-21 76.3 0.0 6.8e-10 38.8 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.23 NM_027403.4_2 - 1.8e-16 59.9 4.8 3.4e-09 36.6 0.5 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.4 NM_027403.4_2 - 1.8e-11 44.1 0.8 2.1e-06 27.8 0.3 4.7 4 3 0 4 4 4 2 Immunoglobulin domain Receptor_2B4 PF11465.6 NM_027403.4_2 - 4.3e-06 26.8 0.1 0.031 14.3 0.0 3.7 4 0 0 4 4 4 2 Natural killer cell receptor 2B4 Herpes_gE PF02480.14 NM_027403.4_2 - 3e-05 22.8 0.1 0.45 9.1 0.0 3.5 3 1 1 4 4 4 2 Alphaherpesvirus glycoprotein E Izumo-Ig PF16706.3 NM_027403.4_2 - 0.13 12.2 0.2 2 8.4 0.0 3.1 5 0 0 5 5 5 0 Izumo-like Immunoglobulin domain 7tm_2 PF00002.22 NM_008101.2_2 - 2.6e-79 265.8 16.2 3.7e-79 265.3 16.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 NM_008101.2_2 - 6.6e-16 58.2 6.0 1.7e-15 56.9 6.0 1.8 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.9 NM_008101.2_2 - 0.059 12.4 13.4 0.1 11.5 13.4 1.3 1 1 0 1 1 1 0 Slime mold cyclic AMP receptor VSP PF03302.11 NM_008101.2_2 - 0.18 10.5 0.6 0.26 10.0 0.6 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein SARAF PF06682.10 NM_026432.3_1 - 3.6e-94 316.0 0.1 4.7e-94 315.6 0.1 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Pkinase PF00069.23 NM_001310452.1_3 - 3.6e-62 210.0 0.0 4.5e-62 209.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001310452.1_3 - 1.3e-29 103.2 0.0 1.8e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_001310452.1_3 - 2.2e-06 27.1 0.2 3.4e-06 26.4 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_001310452.1_3 - 0.0011 18.2 0.0 0.0017 17.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 NM_001310452.1_3 - 0.0043 16.5 0.4 0.0075 15.8 0.4 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 NM_001310452.1_3 - 0.0046 16.8 0.0 0.0073 16.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.23 NM_028126.3_3 - 2.9e-35 121.8 0.0 3.7e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_028126.3_3 - 2.1e-24 86.1 0.0 1.8e-22 79.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Transglut_C PF00927.20 NM_001166391.1_3 - 1.2e-43 147.4 0.1 8.8e-23 80.3 0.2 2.3 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.18 NM_001166391.1_3 - 2.6e-33 114.7 0.1 1.8e-32 112.0 0.0 2.4 3 0 0 3 3 3 1 Transglutaminase family Transglut_core PF01841.17 NM_001166391.1_3 - 5.5e-17 62.1 0.1 1.1e-16 61.1 0.1 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily PB1 PF00564.22 NM_001252443.1_1 - 6.9e-11 41.8 0.3 1e-10 41.2 0.3 1.2 1 0 0 1 1 1 1 PB1 domain MucBP PF06458.10 NM_001252443.1_1 - 0.7 10.8 4.4 7.3 7.6 0.0 3.1 2 1 1 3 3 3 0 MucBP domain Ski_Sno PF02437.15 NM_001163755.1_3 - 1.8e-38 130.5 0.1 3.2e-38 129.7 0.1 1.4 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.8 NM_001163755.1_3 - 6.9e-31 106.2 1.1 6.9e-31 106.2 1.1 1.7 2 0 0 2 2 2 1 c-SKI Smad4 binding domain Bcl-2 PF00452.17 NM_001142960.1_2 - 0.016 15.6 0.0 0.03 14.7 0.0 1.5 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family V1R PF03402.12 NM_145847.1_1 - 1.2e-34 120.0 15.5 1.7e-34 119.5 15.5 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_145847.1_1 - 7.3e-16 58.0 22.4 8.7e-16 57.7 22.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MNSV_P7B PF06692.9 NM_145847.1_1 - 0.01 15.7 3.0 13 5.8 0.1 3.7 3 0 0 3 3 3 0 Melon necrotic spot virus P7B protein 7tm_1 PF00001.19 NM_145847.1_1 - 0.17 10.9 18.9 0.37 9.9 18.8 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) MKRN1_C PF15815.3 NM_018810.2_3 - 6.2e-41 138.6 3.4 1.2e-40 137.7 3.4 1.4 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase makorin-1, C-terminal Torus PF16131.3 NM_018810.2_3 - 6.7e-18 65.2 15.4 6.1e-05 23.5 0.6 4.4 3 1 1 4 4 4 4 Torus domain zf-CCCH PF00642.22 NM_018810.2_3 - 6.7e-17 60.8 34.5 3.1e-05 23.6 4.5 4.9 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4 PF00097.23 NM_018810.2_3 - 9.4e-07 28.5 7.3 9.4e-07 28.5 7.3 3.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_3 PF15663.3 NM_018810.2_3 - 9e-06 25.8 3.3 9e-06 25.8 3.3 3.1 3 0 0 3 3 3 1 Zinc-finger containing family zf-RING_UBOX PF13445.4 NM_018810.2_3 - 6.1e-05 22.8 2.8 6.1e-05 22.8 2.8 2.5 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 NM_018810.2_3 - 0.00016 21.8 6.0 0.00016 21.8 6.0 4.6 5 0 0 5 5 4 1 Ring finger domain zf-RING_5 PF14634.4 NM_018810.2_3 - 0.00023 20.9 6.3 0.00023 20.9 6.3 3.4 3 0 0 3 3 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 NM_018810.2_3 - 0.0017 18.2 2.7 0.0017 18.2 2.7 3.7 4 0 0 4 4 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 NM_018810.2_3 - 0.0019 18.3 5.2 0.0019 18.3 5.2 3.9 5 0 0 5 5 3 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.4 NM_018810.2_3 - 0.0053 16.8 3.9 0.0053 16.8 3.9 3.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-CCCH_2 PF14608.4 NM_018810.2_3 - 0.0067 16.7 34.5 0.23 11.9 3.9 5.4 5 0 0 5 5 5 3 RNA-binding, Nab2-type zinc finger DUF4929 PF16283.3 NM_018810.2_3 - 0.18 10.7 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4929) zf-C3HC4_2 PF13923.4 NM_018810.2_3 - 1.4 8.7 19.9 0.098 12.4 7.4 4.4 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF3915 PF13054.4 NM_011595.2_1 - 0.24 11.3 5.7 0.084 12.7 2.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) TIMP PF00965.15 NM_011595.2_2 - 3.1e-64 216.0 7.3 4.4e-64 215.5 7.3 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Guanylate_cyc PF00211.18 NM_009622.1_1 - 4.4e-128 423.9 0.5 2.3e-65 219.5 0.1 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.3 NM_009622.1_1 - 2.3e-27 96.0 0.1 2.3e-27 96.0 0.1 2.2 2 1 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.12 NM_009622.1_1 - 0.068 13.6 0.4 0.11 12.9 0.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) PBC PF03792.11 NM_008783.3_3 - 3.8e-94 313.7 0.7 5.7e-94 313.1 0.7 1.3 1 0 0 1 1 1 1 PBC domain Homeobox PF00046.27 NM_008783.3_3 - 4.1e-19 68.0 0.9 9.6e-19 66.8 0.9 1.7 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_008783.3_3 - 2.2e-16 59.3 0.0 4.4e-15 55.2 0.0 2.8 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.3 NM_008783.3_3 - 0.014 15.1 0.0 0.034 13.9 0.0 1.6 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_3 PF01381.20 NM_008783.3_3 - 0.041 13.8 0.0 0.087 12.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix PrmA PF06325.11 NM_001252094.1_3 - 1.4e-10 41.0 0.1 2e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.7 NM_001252094.1_3 - 6.5e-08 32.4 0.0 1.3e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.12 NM_001252094.1_3 - 8.8e-06 25.2 0.0 1.3e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.14 NM_001252094.1_3 - 0.00087 18.9 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.4 NM_001252094.1_3 - 0.0048 16.7 0.0 0.011 15.5 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_001252094.1_3 - 0.017 15.7 0.0 0.028 15.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001252094.1_3 - 0.19 11.4 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Hormone_2 PF00123.18 NM_001315504.1_1 - 9.8e-24 82.9 1.0 1.1e-11 44.3 0.2 2.4 2 0 0 2 2 2 2 Peptide hormone VWD PF00094.23 NM_080457.3_3 - 1.1e-27 97.1 0.0 1.1e-27 97.1 0.0 8.5 10 2 2 12 12 12 1 von Willebrand factor type D domain NIDO PF06119.12 NM_080457.3_3 - 8e-14 52.3 0.0 8e-14 52.3 0.0 7.3 6 1 1 7 7 7 1 Nidogen-like EGF PF00008.25 NM_080457.3_3 - 0.59 10.4 30.5 0.22 11.7 9.8 3.4 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.5 NM_080457.3_3 - 1.6 9.4 23.1 0.81 10.3 6.3 3.1 2 0 0 2 2 2 0 Human growth factor-like EGF Pkinase PF00069.23 NM_007659.3_2 - 5.5e-76 255.3 0.0 6.7e-76 255.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_007659.3_2 - 2.1e-33 115.6 0.0 3.1e-33 115.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_007659.3_2 - 0.012 14.9 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.21 NM_007659.3_2 - 0.024 14.5 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 NM_007659.3_2 - 0.046 12.9 0.0 0.098 11.9 0.0 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GMP_PDE_delta PF05351.9 NM_001313988.1_3 - 8.3e-76 253.2 0.7 1e-75 252.9 0.7 1.1 1 0 0 1 1 1 1 GMP-PDE, delta subunit IIGP PF05049.11 NM_001313988.1_3 - 0.19 10.6 0.1 0.27 10.1 0.1 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Kinesin PF00225.21 NM_010616.3_1 - 5.7e-89 298.2 0.0 7.8e-89 297.7 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 NM_010616.3_1 - 5.8e-14 52.2 0.0 9.9e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding Herpes_BLRF2 PF05812.10 NM_010616.3_1 - 2.4 8.2 6.9 1.6 8.7 0.3 2.8 2 1 1 3 3 3 0 Herpesvirus BLRF2 protein bZIP_2 PF07716.13 NM_010616.3_1 - 9.2 6.3 14.7 3.6 7.6 1.4 3.5 2 1 1 3 3 3 0 Basic region leucine zipper Amino_oxidase PF01593.22 NM_001167818.1_2 - 8e-14 51.6 0.0 3.7e-12 46.1 0.0 2.1 1 1 1 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 NM_001167818.1_2 - 1.6e-09 37.8 0.3 4.6e-09 36.2 0.1 2.0 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.12 NM_001167818.1_2 - 0.00067 18.9 0.0 0.75 8.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.14 NM_001167818.1_2 - 0.006 16.1 0.5 0.5 9.9 0.0 2.3 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.25 NM_001167818.1_2 - 0.21 12.0 0.1 21 5.6 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase EF-hand_7 PF13499.4 NM_027031.3_1 - 7.7e-07 29.4 5.4 0.0027 18.0 1.5 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 NM_027031.3_1 - 0.00036 20.1 1.6 0.27 10.9 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_027031.3_1 - 0.0025 17.1 5.0 0.013 14.9 0.3 3.2 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 NM_027031.3_1 - 0.02 14.7 7.5 0.38 10.7 0.7 4.0 4 0 0 4 4 4 0 EF-hand domain EmrE PF13536.4 NM_027031.3_1 - 0.14 11.6 0.1 0.2 11.1 0.1 1.1 1 0 0 1 1 1 0 Putative multidrug resistance efflux transporter DUF3915 PF13054.4 NM_027031.3_1 - 0.33 10.8 2.8 0.44 10.4 1.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) VHS PF00790.17 NM_001159328.1_3 - 1.5e-47 160.9 1.5 1.5e-47 160.9 1.5 1.8 2 0 0 2 2 2 1 VHS domain Hrs_helical PF12210.6 NM_001159328.1_3 - 5.1e-38 129.4 2.9 5.1e-38 129.4 2.9 2.5 2 0 0 2 2 2 1 Hepatocyte growth factor-regulated tyrosine kinase substrate FYVE PF01363.19 NM_001159328.1_3 - 5.6e-18 64.7 9.5 1.4e-17 63.4 9.5 1.6 1 0 0 1 1 1 1 FYVE zinc finger DUF3361 PF11841.6 NM_001159328.1_3 - 0.0022 17.8 0.9 0.0022 17.8 0.9 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) FYVE_2 PF02318.14 NM_001159328.1_3 - 0.0041 17.2 3.8 0.0041 17.2 3.8 3.0 2 1 0 2 2 2 1 FYVE-type zinc finger UIM PF02809.18 NM_001159328.1_3 - 0.091 12.6 7.7 0.24 11.3 7.7 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif DZR PF12773.5 NM_001159328.1_3 - 4.2 7.3 10.0 4.5e+02 0.8 10.0 2.7 1 1 0 1 1 1 0 Double zinc ribbon Arf PF00025.19 NM_007477.5_2 - 7.1e-78 259.9 0.1 1e-77 259.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 NM_007477.5_2 - 2.1e-13 50.0 0.0 2.9e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 NM_007477.5_2 - 9e-13 48.4 0.0 1.3e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_007477.5_2 - 5.6e-11 42.2 0.0 7.5e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.10 NM_007477.5_2 - 1.4e-10 40.8 0.0 1.9e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.18 NM_007477.5_2 - 2.1e-10 40.2 1.1 3.2e-07 29.7 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 NM_007477.5_2 - 0.00025 21.0 0.0 0.00039 20.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 NM_007477.5_2 - 0.094 11.9 0.4 0.14 11.3 0.1 1.3 2 0 0 2 2 2 0 6-phosphofructo-2-kinase Carn_acyltransf PF00755.18 NM_009891.2_1 - 1.3e-195 651.3 0.0 1.5e-195 651.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase 7tm_4 PF13853.4 NM_146925.1_1 - 1.2e-49 169.4 15.8 1.6e-49 169.0 15.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146925.1_1 - 2.4e-18 66.2 18.0 2.4e-18 66.2 18.0 2.2 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_146925.1_1 - 0.11 11.9 0.3 0.31 10.5 0.2 1.7 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus DUF2842 PF11003.6 NM_146925.1_1 - 6.1 7.0 8.8 0.28 11.4 1.4 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2842) SH2 PF00017.22 NM_029983.5_3 - 1.3e-19 69.9 0.0 2e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.4 NM_029983.5_3 - 3.7e-06 26.6 0.0 2.2e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 NM_029983.5_3 - 4.4e-05 22.9 0.0 0.0001 21.7 0.0 1.7 1 0 0 1 1 1 1 SH3 domain C2-set_2 PF08205.10 NM_008990.3_2 - 4.8e-19 68.1 0.0 1.5e-18 66.5 0.0 1.9 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 NM_008990.3_2 - 1.2e-16 60.5 0.0 2.4e-07 30.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 NM_008990.3_2 - 7e-15 55.3 0.2 0.00023 21.6 0.1 3.7 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_008990.3_2 - 1.1e-10 41.5 0.0 6.7e-10 39.0 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 NM_008990.3_2 - 3e-06 27.4 0.0 0.02 15.1 0.0 3.6 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 NM_008990.3_2 - 0.0011 18.8 0.0 0.7 9.9 0.0 3.4 3 1 0 3 3 3 1 Immunoglobulin I-set domain PDDEXK_1 PF12705.5 NM_001289631.1_3 - 1e-06 28.7 0.0 3.4e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily AKNA PF12443.6 NM_001305432.1_1 - 8.9e-34 115.9 2.8 8.9e-34 115.9 2.8 3.3 3 0 0 3 3 3 1 AT-hook-containing transcription factor Metal_resist PF13801.4 NM_001305432.1_1 - 9.6 6.3 14.5 5 7.2 4.0 3.7 3 0 0 3 3 3 0 Heavy-metal resistance Ig_2 PF13895.4 NM_001160215.1_2 - 1.1e-19 70.4 0.0 3.9e-09 36.6 0.0 2.7 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.4 NM_001160215.1_2 - 2.6e-16 59.9 0.0 1.1e-07 32.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001160215.1_2 - 2.1e-08 34.1 0.2 5.6e-05 23.1 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_001160215.1_2 - 1.8e-06 27.9 0.1 0.17 11.9 0.0 3.7 2 2 1 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.14 NM_001160215.1_2 - 0.00028 20.8 0.0 1.3 9.0 0.0 3.2 2 2 0 2 2 2 2 Immunoglobulin I-set domain Izumo-Ig PF16706.3 NM_001160215.1_2 - 0.1 12.5 0.1 11 6.0 0.0 2.8 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 NM_001160215.1_2 - 0.15 12.3 0.0 0.63 10.3 0.0 2.0 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Fibrinogen_C PF00147.16 NM_001286062.1_1 - 4.1e-69 232.6 6.1 5.7e-69 232.2 6.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4239 PF14023.4 NM_001286062.1_1 - 0.41 10.2 6.6 0.34 10.5 5.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4239) DUF3504 PF12012.6 NM_001142731.1_1 - 1.4e-29 102.9 0.6 5.9e-29 100.9 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3504) BTB_2 PF02214.20 NM_001142731.1_1 - 1.4e-16 60.4 0.1 2.9e-16 59.4 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain Phage_int_SAM_1 PF02899.15 NM_001142731.1_1 - 0.095 12.9 0.7 0.22 11.7 0.7 1.6 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain DUF3915 PF13054.4 NM_001142731.1_1 - 4.3 7.2 10.6 0.055 13.3 2.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 NM_001142731.1_3 - 0.15 11.9 11.1 0.29 11.0 11.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) PH PF00169.27 NM_001177898.1_1 - 1.6e-19 70.2 0.9 2.5e-19 69.6 0.9 1.3 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 NM_001177898.1_1 - 1.5e-05 25.2 0.3 0.00019 21.6 0.3 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 NM_001177898.1_1 - 0.00012 22.3 1.8 0.00042 20.6 1.8 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 NM_001177898.1_1 - 0.00013 21.9 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.26 NM_001177898.1_1 - 0.0038 16.7 0.0 0.0099 15.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_001177898.1_1 - 0.0071 15.9 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 NM_001177898.1_1 - 0.029 14.1 0.0 0.077 12.7 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain PH_12 PF16457.3 NM_001177898.1_1 - 0.098 13.1 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Flavodoxin_1 PF00258.23 NM_178897.4_3 - 2.4e-24 86.0 0.0 3.3e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin Pyridoxal_deC PF00282.17 NM_144942.4_1 - 7.6e-111 370.3 0.0 9.3e-111 370.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 NM_144942.4_1 - 1.4e-05 24.1 0.0 2.6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 NM_144942.4_1 - 0.001 18.3 0.0 0.0014 17.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase EGF_CA PF07645.13 NM_021474.3_3 - 3.3e-48 161.5 85.0 3.1e-11 43.2 5.8 8.2 8 0 0 8 8 8 6 Calcium-binding EGF domain cEGF PF12662.5 NM_021474.3_3 - 2.3e-36 123.2 53.2 4e-10 39.3 0.4 7.7 8 0 0 8 8 8 6 Complement Clr-like EGF-like FXa_inhibition PF14670.4 NM_021474.3_3 - 2.1e-13 50.2 92.6 1.4e-06 28.3 7.6 8.8 8 1 0 8 8 8 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 NM_021474.3_3 - 1e-07 31.9 63.9 8.3e-05 22.6 6.2 7.3 7 1 0 7 7 7 5 EGF domain EGF PF00008.25 NM_021474.3_3 - 0.00016 21.7 88.0 0.0013 18.9 7.9 8.2 8 0 0 8 8 8 4 EGF-like domain hEGF PF12661.5 NM_021474.3_3 - 0.0027 18.2 84.8 0.0054 17.2 4.0 9.9 11 0 0 11 11 11 5 Human growth factor-like EGF SNARE PF05739.17 NM_001102423.1_2 - 5.4e-18 64.6 2.3 5.4e-18 64.6 2.3 2.7 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.23 NM_001102423.1_2 - 1.1e-06 28.4 11.4 3.3e-06 26.8 11.4 1.7 1 1 0 1 1 1 1 Syntaxin MCPsignal PF00015.19 NM_001102423.1_2 - 0.087 12.5 1.2 0.4 10.3 0.1 2.1 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Synaptobrevin PF00957.19 NM_001102423.1_2 - 0.18 11.5 2.7 0.59 9.8 2.7 1.9 1 0 0 1 1 1 0 Synaptobrevin Syntaxin_2 PF14523.4 NM_001102423.1_2 - 0.32 11.2 7.3 0.27 11.5 1.7 2.3 2 0 0 2 2 2 0 Syntaxin-like protein ThiF PF00899.19 NM_001136085.2_3 - 3.6e-123 409.5 0.0 2.4e-74 249.6 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.7 NM_001136085.2_3 - 3.1e-97 325.3 0.0 4.5e-97 324.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.8 NM_001136085.2_3 - 9.7e-37 125.5 0.0 1.8e-36 124.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.3 NM_001136085.2_3 - 8.9e-34 115.4 0.1 1.6e-33 114.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.3 NM_001136085.2_3 - 8.1e-25 86.7 0.3 2.2e-24 85.3 0.3 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle ATG16 PF08614.9 NM_145688.2_1 - 0.0067 16.5 19.7 0.02 14.9 14.5 2.2 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) YjcZ PF13990.4 NM_145688.2_1 - 0.028 13.7 6.1 0.038 13.2 6.1 1.3 1 0 0 1 1 1 0 YjcZ-like protein CLZ PF16526.3 NM_145688.2_1 - 0.15 12.3 0.3 0.15 12.3 0.3 3.1 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF641 PF04859.10 NM_145688.2_1 - 0.22 11.8 15.8 0.073 13.3 10.3 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) betaPIX_CC PF16523.3 NM_145688.2_1 - 0.46 10.2 9.8 3.7 7.3 5.8 2.4 2 0 0 2 2 2 0 betaPIX coiled coil DUF4200 PF13863.4 NM_145688.2_1 - 0.63 10.3 26.0 2.1 8.6 0.2 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) FCH PF00611.21 NM_145688.2_1 - 0.8 9.9 7.9 6.2 7.0 3.1 2.7 2 1 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Leu_zip PF15294.4 NM_145688.2_1 - 0.89 8.9 19.6 1.5 8.1 19.2 1.6 1 1 0 1 1 1 0 Leucine zipper Exonuc_VII_L PF02601.13 NM_145688.2_1 - 0.99 8.8 14.4 1.4 8.3 14.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.10 NM_145688.2_1 - 2.2 8.2 11.5 7 6.6 0.3 2.2 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.4 NM_145688.2_1 - 3 7.0 20.1 5.2 6.2 15.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF3574 PF12098.6 NM_145688.2_1 - 5.1 6.8 7.0 24 4.6 0.6 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3574) Caudo_TAP PF02413.15 NM_145688.2_1 - 5.2 7.2 12.8 1.3 9.1 4.2 2.6 1 1 2 3 3 3 0 Caudovirales tail fibre assembly protein, lambda gpK 5_nucleotid PF05761.12 NM_145688.2_1 - 8.6 5.0 11.1 12 4.6 10.8 1.3 1 1 0 1 1 1 0 5' nucleotidase family LIM PF00412.20 NM_001142336.1_3 - 9.1e-27 92.9 20.7 9.2e-15 54.5 9.0 2.3 2 0 0 2 2 2 2 LIM domain CAP_N PF01213.17 NM_001142336.1_3 - 2.6 7.3 6.1 3.8 6.8 6.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRKCSH-like PF12999.5 NM_001293650.1_3 - 5.2e-42 143.5 4.9 5.2e-42 143.5 4.9 2.2 2 1 1 3 3 3 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.4 NM_001293650.1_3 - 3.7e-20 72.0 0.0 6.8e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.11 NM_001293650.1_3 - 7.5e-10 39.6 0.5 7.5e-10 39.6 0.5 2.3 2 0 0 2 2 1 1 Glucosidase II beta subunit-like protein EF-hand_5 PF13202.4 NM_001293650.1_3 - 1.1e-08 34.1 0.2 0.00077 18.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.30 NM_001293650.1_3 - 6.2e-06 25.3 0.0 0.15 11.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_001293650.1_3 - 2.1e-05 23.9 0.1 0.26 11.2 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain Ldl_recept_a PF00057.16 NM_001293650.1_3 - 0.00022 21.2 9.5 0.031 14.4 2.8 2.6 1 1 1 2 2 2 2 Low-density lipoprotein receptor domain class A EF-hand_7 PF13499.4 NM_001293650.1_3 - 0.00053 20.3 0.2 1.3 9.4 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 NM_001293650.1_3 - 0.0048 16.5 0.2 1.8 8.2 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair DUF3450 PF11932.6 NM_001293650.1_3 - 0.41 9.8 14.6 2.5 7.2 8.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Sec34 PF04136.13 NM_001293650.1_3 - 3.1 7.6 5.8 20 4.9 0.1 2.2 2 0 0 2 2 2 0 Sec34-like family Pyr_redox_3 PF13738.4 NM_145950.4_1 - 3e-07 29.9 0.0 0.00046 19.4 0.0 3.1 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Cadherin PF00028.15 NM_181682.2_3 - 3.9e-53 177.7 2.2 4e-19 68.7 0.0 4.5 4 0 0 4 4 4 4 Cadherin domain Cadherin_C PF01049.15 NM_181682.2_3 - 3.5e-08 33.7 0.0 6.3e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 NM_181682.2_3 - 0.0011 18.9 1.0 0.047 13.6 0.2 2.6 2 0 0 2 2 2 1 Cadherin-like NHL PF01436.19 NM_001271726.1_1 - 2.7e-48 159.5 18.1 2.9e-09 36.3 0.2 6.6 6 0 0 6 6 6 6 NHL repeat DUF5128 PF17170.2 NM_001271726.1_1 - 6.5e-17 61.6 8.9 1.7e-07 30.6 0.6 4.1 2 2 1 3 3 3 3 6-bladed beta-propeller Filamin PF00630.17 NM_001271726.1_1 - 1.4e-16 61.0 0.0 3.1e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-B_box PF00643.22 NM_001271726.1_1 - 3.1e-10 39.9 3.3 3.1e-10 39.9 3.3 3.4 3 0 0 3 3 2 1 B-box zinc finger SGL PF08450.10 NM_001271726.1_1 - 4.6e-09 36.1 2.6 0.00049 19.6 0.1 4.6 2 2 3 5 5 5 2 SMP-30/Gluconolaconase/LRE-like region zf-RING_UBOX PF13445.4 NM_001271726.1_1 - 2.2e-08 33.8 11.0 2.2e-08 33.8 11.0 3.1 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_001271726.1_1 - 2.1e-07 30.5 10.7 2.1e-07 30.5 10.7 4.0 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_001271726.1_1 - 2.4e-07 30.3 10.0 2.4e-07 30.3 10.0 4.0 5 0 0 5 5 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001271726.1_1 - 6.6e-07 29.0 8.1 6.6e-07 29.0 8.1 3.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001271726.1_1 - 1.4e-06 28.0 9.0 1.4e-06 28.0 9.0 3.9 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_001271726.1_1 - 2e-06 27.8 9.7 2e-06 27.8 9.7 5.0 4 0 0 4 4 4 1 Ring finger domain Prok-RING_4 PF14447.4 NM_001271726.1_1 - 2.4e-05 24.0 8.9 2.4e-05 24.0 8.9 3.5 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 DUF4934 PF16288.3 NM_001271726.1_1 - 0.00011 21.9 1.0 0.24 11.2 0.2 2.9 2 1 1 3 3 3 2 Domain of unknown function (DUF4934) zf-C3HC4_4 PF15227.4 NM_001271726.1_1 - 0.00097 19.1 11.5 0.00097 19.1 11.5 3.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Caskin-tail PF16632.3 NM_001271726.1_1 - 0.045 14.0 0.7 0.091 13.1 0.7 1.5 1 0 0 1 1 1 0 C-terminal region of Caskin zf-ANAPC11 PF12861.5 NM_001271726.1_1 - 0.082 12.8 3.9 0.062 13.2 1.4 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 NM_001271726.1_1 - 0.15 11.6 7.0 0.37 10.4 4.4 2.9 2 0 0 2 2 2 0 RING-like zinc finger SBBP PF06739.9 NM_001271726.1_1 - 0.16 11.8 1.2 1.8 8.5 0.4 2.5 2 0 0 2 2 2 0 Beta-propeller repeat Dzip-like_N PF13815.4 NM_001271726.1_1 - 4.4 7.2 7.5 11 5.9 6.1 2.2 2 0 0 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal Sugar_tr PF00083.22 NM_172776.2_2 - 1.3e-23 83.4 18.5 2e-23 82.8 18.5 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 NM_172776.2_2 - 6.2e-22 77.9 30.9 9e-12 44.4 14.3 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3099 PF11298.6 NM_172776.2_2 - 0.21 11.6 6.1 0.089 12.8 1.9 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3099) LIM PF00412.20 NM_033652.5_2 - 1.5e-29 101.8 26.3 2.5e-15 56.3 7.9 2.5 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 NM_033652.5_2 - 2.8e-17 62.2 2.3 5.5e-17 61.2 2.3 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_033652.5_2 - 0.00041 20.1 0.0 0.00089 19.0 0.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain MITF_TFEB_C_3_N PF15951.3 NM_001324471.1_1 - 0.033 14.7 0.0 0.05 14.1 0.0 1.1 1 0 0 1 1 1 0 MITF/TFEB/TFEC/TFE3 N-terminus LRR_4 PF12799.5 NM_001324471.1_1 - 0.21 11.9 17.6 4.4 7.7 0.3 4.7 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) Trypsin PF00089.24 NM_023182.2_3 - 1e-72 244.4 4.3 1.2e-72 244.2 4.3 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 NM_023182.2_3 - 2.8e-07 31.4 0.4 4.9e-07 30.6 0.4 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 NM_023182.2_3 - 5.5e-06 26.6 0.1 2.1e-05 24.7 0.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) DUF316 PF03761.13 NM_023182.2_3 - 0.0017 17.9 0.0 0.014 14.9 0.0 2.3 1 1 0 1 1 1 1 Chymotrypsin family Peptidase-S1 Peptidase_C37 PF05416.10 NM_023182.2_3 - 0.044 12.2 0.4 0.078 11.4 0.4 1.4 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Pico_P2A PF00947.17 NM_023182.2_3 - 0.087 12.7 0.6 0.16 11.9 0.6 1.4 1 0 0 1 1 1 0 Picornavirus core protein 2A CC2-LZ PF16516.3 NM_001161422.1_1 - 3.1e-28 98.0 18.1 3.1e-28 98.0 18.1 3.3 1 1 2 3 3 3 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator NEMO PF11577.6 NM_001161422.1_1 - 1.1e-27 95.6 12.4 1.1e-27 95.6 12.4 3.6 3 1 1 4 4 4 1 NF-kappa-B essential modulator NEMO LLC1 PF14945.4 NM_001161422.1_1 - 0.33 11.4 2.7 0.42 11.1 0.1 2.2 2 0 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Filament PF00038.19 NM_001161422.1_1 - 1.9 7.8 48.1 2.9 7.3 48.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein CorA PF01544.16 NM_001161422.1_1 - 9.1 5.4 20.0 0.12 11.6 12.2 1.7 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein AP3D1 PF06375.9 NM_153144.2_1 - 2.4 8.3 10.2 1.4 9.1 1.8 2.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 DUF4710 PF15828.3 NM_153144.2_1 - 8.1 6.5 14.6 1.4 8.9 3.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Aquarius_N PF16399.3 NM_001290788.1_3 - 0 1077.3 0.3 0 1076.9 0.3 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.4 NM_001290788.1_3 - 3.5e-29 102.2 0.0 9.6e-29 100.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.4 NM_001290788.1_3 - 1.8e-25 89.6 0.0 9.3e-25 87.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.4 NM_001290788.1_3 - 3.4e-08 33.8 0.0 1.8e-07 31.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.4 NM_001290788.1_3 - 4.8e-06 26.3 0.0 0.0026 17.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain ResIII PF04851.13 NM_001290788.1_3 - 1e-05 25.5 0.0 2.6e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Parvo_NS1 PF01057.15 NM_001290788.1_3 - 0.00082 18.4 0.0 0.0015 17.6 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 DUF2075 PF09848.7 NM_001290788.1_3 - 0.0019 17.4 0.1 0.023 13.8 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.27 NM_001290788.1_3 - 0.0027 17.4 0.0 0.0053 16.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD_C_2 PF13538.4 NM_001290788.1_3 - 0.0033 17.1 0.3 0.0068 16.1 0.3 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.4 NM_001290788.1_3 - 0.0045 17.2 0.4 0.021 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.27 NM_001290788.1_3 - 0.0061 16.8 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.19 NM_001290788.1_3 - 0.008 15.6 0.1 0.024 14.0 0.0 1.9 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain DnaB_C PF03796.13 NM_001290788.1_3 - 0.0087 15.2 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain DUF4088 PF13317.4 NM_001290788.1_3 - 0.032 13.7 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) PhoH PF02562.14 NM_001290788.1_3 - 0.035 13.4 0.0 0.069 12.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein CRS1_YhbY PF01985.19 NM_001290788.1_3 - 0.056 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 CRS1 / YhbY (CRM) domain AAA_22 PF13401.4 NM_001290788.1_3 - 0.096 12.8 0.2 0.61 10.2 0.1 2.3 1 1 1 2 2 2 0 AAA domain RecA PF00154.19 NM_001290788.1_3 - 0.17 11.2 0.0 0.3 10.4 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein ATPase PF06745.11 NM_001290788.1_3 - 0.19 10.9 0.0 0.39 9.9 0.0 1.4 1 0 0 1 1 1 0 KaiC PROL5-SMR PF15621.4 NM_001252679.1_1 - 9.2e-07 29.2 0.1 2e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 Proline-rich submaxillary gland androgen-regulated family PROL5-SMR PF15621.4 NM_001252679.1_3 - 6.2e-32 110.0 9.9 8.8e-32 109.6 9.9 1.3 1 0 0 1 1 1 1 Proline-rich submaxillary gland androgen-regulated family HSP70 PF00012.18 NM_001327998.1_2 - 4.7e-06 24.9 0.0 0.084 10.9 0.0 2.9 3 0 0 3 3 3 3 Hsp70 protein RRM_1 PF00076.20 NM_133188.2_1 - 3.1e-36 122.9 0.2 1.8e-17 62.8 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_133188.2_1 - 3.4e-14 52.6 0.2 2.2e-07 30.7 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 NM_133188.2_1 - 8.6e-06 25.5 0.1 0.029 14.2 0.1 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.4 NM_133188.2_1 - 0.0016 18.6 0.1 1.3 9.1 0.0 2.8 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter CSD PF00313.20 NM_133188.2_1 - 0.11 12.2 1.4 2.5 7.9 0.1 2.4 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain APOBEC_N PF08210.9 NM_009645.2_1 - 2.9e-62 209.6 1.0 4.6e-62 209.0 1.0 1.3 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 NM_009645.2_1 - 2e-27 94.8 0.0 3.8e-27 93.9 0.0 1.5 1 0 0 1 1 1 1 APOBEC-like C-terminal domain RcbX PF02341.13 NM_009645.2_1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 RbcX protein Glyco_hydro_47 PF01532.18 NM_207237.3_3 - 7.6e-144 479.9 0.0 9.3e-144 479.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Interferon PF00143.17 NM_001161610.1_1 - 5.4e-27 94.8 0.0 7e-27 94.4 0.0 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain NAGLU_N PF12971.5 NM_001161610.1_1 - 0.063 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain EamA PF00892.18 NM_029529.3_3 - 3.3e-05 23.9 33.6 0.0063 16.6 15.0 2.4 2 0 0 2 2 2 2 EamA-like transporter family NAC PF01849.16 NM_145455.3_2 - 3.4e-26 90.9 0.8 6.7e-26 89.9 0.2 1.8 2 0 0 2 2 2 1 NAC domain Tubulin PF00091.23 NM_009450.2_2 - 1.8e-68 230.5 0.0 2.7e-68 229.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_009450.2_2 - 3.6e-43 146.7 0.1 5.7e-43 146.0 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 NM_009450.2_2 - 1.4e-05 25.2 0.0 3.5e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 NM_009450.2_2 - 0.022 14.3 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 NM_009450.2_2 - 0.023 13.8 0.0 0.045 12.8 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Vasohibin PF14822.4 NM_144879.2_2 - 4.3e-120 399.3 0.1 5.5e-120 399.0 0.1 1.1 1 0 0 1 1 1 1 Vasohibin DicB PF05358.9 NM_144879.2_2 - 0.14 12.2 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 DicB protein 7tm_1 PF00001.19 NM_001010837.1_1 - 5.6e-55 186.3 15.4 7.3e-55 185.9 15.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001010837.1_1 - 1.6e-12 47.2 18.0 2e-12 46.9 18.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001010837.1_1 - 1.1e-05 24.8 12.5 1.1e-05 24.8 12.5 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 NM_001010837.1_1 - 0.031 13.9 14.8 0.15 11.6 10.7 2.3 2 1 0 2 2 2 0 Olfactory receptor RRM_1 PF00076.20 NM_001195487.1_2 - 4.5e-16 58.3 0.0 6.7e-16 57.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 NM_001195487.1_2 - 0.0021 17.5 0.0 0.0034 16.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 NM_001195487.1_2 - 0.0041 17.0 7.7 0.0041 17.0 7.7 2.3 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_3 PF13917.4 NM_001195487.1_2 - 0.0045 16.8 2.6 0.01 15.7 2.6 1.6 1 0 0 1 1 1 1 Zinc knuckle 7tm_4 PF13853.4 NM_146598.2_2 - 1.3e-47 162.8 14.1 1.6e-47 162.5 14.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146598.2_2 - 6.9e-21 74.5 13.7 6.9e-21 74.5 13.7 1.8 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146598.2_2 - 1.6e-06 27.5 11.9 2.2e-06 27.1 11.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_146598.2_2 - 0.018 14.3 7.3 0.05 12.8 7.3 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Trypsin_2 PF13365.4 NM_026640.2_2 - 1.7e-18 67.8 0.0 3.6e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.24 NM_026640.2_2 - 2.7e-05 24.0 0.0 6.8e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Trypsin Peptidase_S7 PF00949.19 NM_026640.2_2 - 0.0052 16.5 0.1 0.013 15.2 0.1 1.6 1 0 0 1 1 1 1 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S46 PF10459.7 NM_026640.2_2 - 0.066 11.7 0.5 0.23 9.9 0.0 1.8 2 0 0 2 2 2 0 Peptidase S46 IRS PF02174.15 NM_177798.3_2 - 2.6e-24 84.9 0.1 4.6e-24 84.1 0.1 1.3 1 0 0 1 1 1 1 PTB domain (IRS-1 type) Dynamin_N PF00350.21 NM_175347.4_1 - 2.3e-12 47.1 0.0 3.1e-11 43.5 0.0 2.4 1 1 0 1 1 1 1 Dynamin family EHD_N PF16880.3 NM_175347.4_1 - 3.5e-10 39.4 0.0 6.9e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.21 NM_175347.4_1 - 4.5e-08 33.1 0.0 8.5e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 NM_175347.4_1 - 0.0071 16.1 0.0 0.13 12.1 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function, DUF258 Transferrin PF00405.15 NM_008522.3_2 - 1.6e-259 859.0 7.3 3.2e-174 578.6 0.0 2.1 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 NM_008522.3_2 - 1.6e-09 37.6 0.0 0.0024 17.4 0.0 3.2 4 0 0 4 4 4 2 ABC transporter, phosphonate, periplasmic substrate-binding protein FCH PF00611.21 NM_001289678.1_3 - 4.9e-16 58.6 1.7 4.9e-16 58.6 0.1 1.9 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.4 NM_001289678.1_3 - 1.1e-14 53.9 0.1 2.3e-14 52.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001289678.1_3 - 2.1e-12 46.3 1.3 3.4e-12 45.6 0.0 2.1 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 NM_001289678.1_3 - 1.3e-06 27.8 0.0 3.6e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain GrpE PF01025.17 NM_001289678.1_3 - 0.17 11.4 8.6 0.027 14.0 3.7 1.9 1 1 1 2 2 2 0 GrpE Tho2 PF11262.6 NM_001289678.1_3 - 0.18 10.9 5.1 0.26 10.3 5.1 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 SHE3 PF17078.3 NM_001289678.1_3 - 0.44 10.1 9.3 0.69 9.5 9.3 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF3450 PF11932.6 NM_001289678.1_3 - 1.1 8.4 9.6 1.7 7.7 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Exonuc_VII_L PF02601.13 NM_001289678.1_3 - 2.1 7.7 5.3 3 7.2 5.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mnd1 PF03962.13 NM_001289678.1_3 - 2.5 7.8 10.4 5.2 6.7 10.4 1.4 1 0 0 1 1 1 0 Mnd1 family APG6 PF04111.10 NM_001289678.1_3 - 8.2 5.6 11.9 12 5.0 11.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Ifi-6-16 PF06140.11 NM_194066.2_2 - 3.8e-26 90.7 24.7 3.8e-26 90.7 24.7 3.1 4 0 0 4 4 4 2 Interferon-induced 6-16 family Pkinase_Tyr PF07714.15 NM_001289766.1_1 - 3.3e-91 305.1 0.0 4.2e-91 304.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001289766.1_1 - 1.4e-44 152.3 0.0 2.2e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 NM_001289766.1_1 - 1.1e-39 134.2 0.1 2.1e-20 72.4 0.1 2.4 2 0 0 2 2 2 2 SH2 domain Kdo PF06293.12 NM_001289766.1_1 - 0.0055 16.0 0.1 0.011 15.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EPTP PF03736.15 NM_001289766.1_1 - 0.23 11.4 1.2 4 7.4 0.1 2.4 2 0 0 2 2 2 0 EPTP domain ATP1G1_PLM_MAT8 PF02038.14 NM_033648.1_1 - 3.7e-24 83.7 0.1 3.7e-24 83.7 0.1 1.8 2 0 0 2 2 2 1 ATP1G1/PLM/MAT8 family Nop10p PF04135.10 NM_025403.4_3 - 5.9e-23 80.5 0.6 8.8e-23 80.0 0.6 1.3 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family R3H PF01424.20 NM_001301651.1_2 - 1.1e-15 57.3 0.1 2.2e-15 56.3 0.1 1.6 1 0 0 1 1 1 1 R3H domain NCBP3 PF10309.7 NM_001301651.1_2 - 5e-06 26.1 0.0 9.4e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 Nop14 PF04147.10 NM_001301651.1_2 - 0.086 10.9 20.0 0.11 10.6 20.0 1.2 1 0 0 1 1 1 0 Nop14-like family Dicty_REP PF05086.10 NM_001301651.1_2 - 0.85 7.4 5.3 1.2 6.9 5.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4366 PF14283.4 NM_001114328.2_3 - 0.011 15.1 4.4 0.012 15.0 0.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) YtxH PF12732.5 NM_001114328.2_3 - 0.011 16.1 5.2 0.068 13.6 4.8 2.6 2 0 0 2 2 2 0 YtxH-like protein C2 PF00168.28 NM_001311085.1_2 - 7.9e-09 35.6 0.1 1.2e-06 28.6 0.1 2.4 2 0 0 2 2 2 1 C2 domain ArgJ PF01960.16 NM_001311085.1_2 - 0.072 11.7 0.0 0.13 10.8 0.0 1.4 1 0 0 1 1 1 0 ArgJ family PEP-utilisers_N PF05524.11 NM_001311085.1_2 - 2 8.5 8.5 1.3 9.1 0.6 2.7 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal Pox_A_type_inc PF04508.10 NM_001311085.1_2 - 3.4 7.6 12.1 0.35 10.7 0.8 3.3 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat V1R PF03402.12 NM_134213.1_1 - 1.1e-31 110.4 8.9 1.1e-31 110.4 8.9 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_134213.1_1 - 2.1e-05 23.6 15.9 3.5e-05 23.0 15.9 1.3 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) PAS_3 PF08447.10 NM_153553.4_3 - 2.3e-16 59.7 0.1 1.1e-11 44.8 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 NM_153553.4_3 - 2.5e-07 30.7 0.0 2.5e-06 27.4 0.0 2.1 2 0 0 2 2 2 1 PAS domain PAS PF00989.23 NM_153553.4_3 - 0.00012 21.9 0.0 0.67 9.8 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 NM_153553.4_3 - 0.0007 19.4 0.5 0.0014 18.4 0.5 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain 7tm_3 PF00003.20 NM_022420.2_3 - 6.8e-35 120.8 24.5 1.1e-34 120.2 24.5 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR 7tm_4 PF13853.4 NM_001011738.1_1 - 8.3e-48 163.4 16.6 1e-47 163.1 16.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011738.1_1 - 1.7e-19 70.0 17.1 3.8e-19 68.8 17.1 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011738.1_1 - 0.0071 15.6 17.0 0.011 15.0 16.9 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SLC3A2_N PF16028.3 NM_001011738.1_1 - 7.8 6.0 6.4 1.3 8.4 0.2 2.6 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus tRNA-synt_2b PF00587.23 NM_001083887.2_2 - 4e-33 114.8 0.0 5.6e-33 114.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.18 NM_001083887.2_2 - 2.1e-08 34.1 0.0 3.6e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Anticodon binding domain G-patch PF01585.21 NM_025630.3_3 - 2.3e-13 49.7 6.5 4.9e-13 48.6 6.5 1.5 1 0 0 1 1 1 1 G-patch domain FHA PF00498.24 NM_025630.3_3 - 5.5e-13 48.9 0.0 1.2e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 FHA domain G-patch_2 PF12656.5 NM_025630.3_3 - 2.1e-05 24.4 2.7 5.8e-05 23.0 2.7 1.8 1 0 0 1 1 1 1 G-patch domain Yop-YscD_cpl PF16697.3 NM_025630.3_3 - 6.9e-05 22.9 0.1 0.00025 21.2 0.0 1.9 2 0 0 2 2 1 1 Inner membrane component of T3SS, cytoplasmic domain CENP-F_leu_zip PF10473.7 NM_025630.3_3 - 0.0034 17.3 5.6 0.0078 16.1 5.6 1.6 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF745 PF05335.11 NM_025630.3_3 - 0.0094 15.6 2.0 0.0094 15.6 2.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF745) Pox_A_type_inc PF04508.10 NM_025630.3_3 - 0.019 14.6 4.2 0.068 12.9 4.2 2.0 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Spc7 PF08317.9 NM_025630.3_3 - 0.032 13.0 4.2 0.054 12.2 4.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Uds1 PF15456.4 NM_025630.3_3 - 0.076 13.0 0.0 0.076 13.0 0.0 2.7 3 0 0 3 3 2 0 Up-regulated During Septation HCMV_UL139 PF12507.6 NM_025630.3_3 - 0.12 12.7 1.0 0.33 11.2 1.0 1.7 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein Jnk-SapK_ap_N PF09744.7 NM_025630.3_3 - 0.12 12.5 6.1 0.28 11.3 6.1 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Laminin_II PF06009.10 NM_025630.3_3 - 0.16 11.9 0.9 0.35 10.8 0.9 1.5 1 0 0 1 1 1 0 Laminin Domain II IncA PF04156.12 NM_025630.3_3 - 0.17 11.5 5.9 0.35 10.5 5.9 1.4 1 0 0 1 1 1 0 IncA protein FH2 PF02181.21 NM_025630.3_3 - 0.17 10.8 0.9 0.27 10.2 0.9 1.2 1 0 0 1 1 1 0 Formin Homology 2 Domain FlaC_arch PF05377.9 NM_025630.3_3 - 0.83 10.0 3.0 3.3 8.1 1.2 2.3 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF3450 PF11932.6 NM_025630.3_3 - 1.7 7.7 4.2 3 7.0 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Radial_spoke PF04712.10 NM_001159671.1_2 - 8.1e-69 232.7 4.8 1.3e-53 182.5 3.3 3.1 1 1 2 3 3 3 2 Radial spokehead-like protein Spc97_Spc98 PF04130.11 NM_133755.2_1 - 1.2e-120 403.7 13.0 3.5e-120 402.2 13.0 1.8 1 1 0 1 1 1 1 Spc97 / Spc98 family zf-Tim10_DDP PF02953.13 NM_133755.2_1 - 0.018 14.5 2.7 0.042 13.4 2.7 1.6 1 0 0 1 1 1 0 Tim10/DDP family zinc finger DUF2894 PF11445.6 NM_133755.2_1 - 0.058 13.7 1.8 0.17 12.2 1.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) BNIP2 PF12496.6 NM_016787.4_3 - 2.3e-32 112.1 0.8 3.6e-32 111.5 0.8 1.3 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 NM_016787.4_3 - 7e-30 103.8 0.1 1.1e-29 103.2 0.1 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 NM_016787.4_3 - 1.1e-06 28.4 0.0 2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain Cofilin_ADF PF00241.18 NM_001146309.1_3 - 5.6e-18 65.2 0.0 9.9e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_9 PF14604.4 NM_001146309.1_3 - 3e-10 39.6 0.2 6.4e-10 38.6 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_001146309.1_3 - 3.8e-10 39.1 0.4 9.9e-10 37.7 0.2 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 NM_001146309.1_3 - 2.1e-05 24.0 0.0 4.9e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain RR_TM4-6 PF06459.10 NM_001146309.1_3 - 1.8 8.2 12.2 2.8 7.6 12.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neuregulin PF02158.13 NM_178591.2_1 - 1.9e-190 633.3 20.5 3.2e-190 632.6 20.5 1.4 1 0 0 1 1 1 1 Neuregulin family EGF PF00008.25 NM_178591.2_1 - 0.00073 19.7 2.9 0.0019 18.3 2.9 1.8 1 0 0 1 1 1 1 EGF-like domain DUF973 PF06157.9 NM_178591.2_1 - 0.083 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF973) Cyt_b-c1_8 PF10890.6 NM_178591.2_1 - 0.1 12.8 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 Pkinase PF00069.23 NM_001164200.1_3 - 8.4e-72 241.6 0.0 1.1e-71 241.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001164200.1_3 - 2.6e-33 115.3 0.0 3.7e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001164200.1_3 - 2.4e-07 30.3 0.1 6e-07 28.9 0.0 1.6 2 0 0 2 2 2 1 Kinase-like RRM_1 PF00076.20 NM_001160292.1_3 - 7.1e-37 124.9 0.0 2.6e-14 52.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 NM_001160292.1_3 - 0.00017 21.4 0.0 0.59 10.1 0.0 2.6 2 0 0 2 2 2 2 RNA binding domain RRM_7 PF16367.3 NM_001160292.1_3 - 0.011 15.7 0.0 1.4 8.9 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.4 NM_001160292.1_3 - 0.057 13.5 1.3 4.5 7.3 0.0 3.4 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Pkinase PF00069.23 NM_009870.3_3 - 4.7e-64 216.2 0.0 5.6e-64 215.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_009870.3_3 - 3e-30 105.3 0.0 4.3e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_009870.3_3 - 5.6e-08 32.9 0.3 0.00011 22.1 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 NM_009870.3_3 - 0.00092 18.5 0.0 0.0014 17.9 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_009870.3_3 - 0.051 12.8 0.0 0.088 12.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like PCI PF01399.25 NM_001285512.1_1 - 2.5e-25 88.9 1.8 2.5e-25 88.9 1.8 2.1 2 0 0 2 2 2 1 PCI domain IQ PF00612.25 NM_001146701.1_1 - 2.4e-13 48.5 25.6 4.5e-05 22.7 0.2 4.3 4 0 0 4 4 4 4 IQ calmodulin-binding motif Asp-B-Hydro_N PF05279.9 NM_001177856.1_1 - 1.4e-47 162.7 5.7 1.9e-47 162.3 5.7 1.1 1 0 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region ATG27 PF09451.8 NM_001177856.1_1 - 0.028 14.2 0.1 0.043 13.5 0.1 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 SR-25 PF10500.7 NM_001177856.1_1 - 4.7 6.6 6.9 7.1 6.0 6.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RasGEF PF00617.17 NM_009058.2_2 - 1.5e-55 187.9 0.2 3e-55 186.9 0.2 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 NM_009058.2_2 - 2.8e-21 75.6 0.0 1.4e-20 73.4 0.0 2.2 2 0 0 2 2 2 1 RasGEF N-terminal motif RA PF00788.21 NM_009058.2_2 - 5.1e-16 59.0 0.0 3.7e-15 56.2 0.1 2.3 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain UQ_con PF00179.24 NM_001313696.1_3 - 1.5e-48 163.9 0.0 2.1e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 NM_001313696.1_3 - 0.0013 18.9 0.1 0.0022 18.1 0.1 1.3 1 0 0 1 1 1 1 RWD domain fn3 PF00041.19 NM_178790.4_3 - 1.9e-16 60.0 4.3 4.7e-10 39.5 0.4 3.4 4 0 0 4 4 4 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_178790.4_3 - 5.5e-06 26.7 1.0 0.082 13.3 0.0 3.0 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 NM_178790.4_3 - 0.00069 19.8 0.0 0.39 10.9 0.0 2.9 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III Beach PF02138.16 NM_001146022.2_3 - 1.3e-120 401.9 0.1 2e-120 401.2 0.1 1.3 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.30 NM_001146022.2_3 - 4.1e-08 33.6 10.6 0.0023 18.6 0.0 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat PH_BEACH PF14844.4 NM_001146022.2_3 - 4.5e-07 29.8 0.1 1.1e-06 28.5 0.1 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4704 PF15787.3 NM_001146022.2_3 - 0.00024 20.3 0.7 0.00024 20.3 0.7 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.4 NM_001146022.2_3 - 0.0034 17.4 0.0 0.0081 16.2 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Fanconi_A PF03511.12 NM_001146022.2_3 - 0.29 10.9 3.7 13 5.6 0.0 3.4 3 0 0 3 3 3 0 Fanconi anaemia group A protein CENP-M PF11111.6 NM_001080158.1_2 - 3.6e-69 231.3 1.1 5.1e-69 230.8 1.1 1.2 1 0 0 1 1 1 1 Centromere protein M (CENP-M) LCE PF14672.4 NM_001281499.1_2 - 1.2e-07 32.1 55.6 1.2e-07 32.1 55.6 5.4 2 1 2 4 4 4 2 Late cornified envelope FA_desaturase PF00487.22 NM_001281499.1_3 - 9.7 5.8 8.0 2.3 7.9 0.5 2.0 2 0 0 2 2 2 0 Fatty acid desaturase BNR_2 PF13088.4 NM_016720.2_2 - 2.6e-35 121.9 0.0 6.7e-35 120.6 0.0 1.6 1 1 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 NM_016720.2_2 - 1.6e-05 24.3 0.0 2.1e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 NM_016720.2_2 - 0.018 14.8 2.1 0.14 12.1 0.3 2.8 3 0 0 3 3 3 0 BNR/Asp-box repeat NACHT PF05729.10 NM_001042612.1_3 - 1.8e-29 102.6 0.1 4.1e-29 101.5 0.1 1.6 1 0 0 1 1 1 1 NACHT domain PYRIN PF02758.14 NM_001042612.1_3 - 5.6e-19 68.0 2.9 2.7e-18 65.8 2.9 2.3 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain LRR_6 PF13516.4 NM_001042612.1_3 - 2e-05 24.1 37.2 0.0022 17.8 0.8 9.1 11 0 0 11 11 11 3 Leucine Rich repeat AAA_16 PF13191.4 NM_001042612.1_3 - 0.015 15.6 0.0 0.15 12.3 0.0 2.4 1 1 0 1 1 1 0 AAA ATPase domain LRR_4 PF12799.5 NM_001042612.1_3 - 0.18 12.1 27.9 0.63 10.4 1.2 6.5 7 0 0 7 7 7 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001042612.1_3 - 0.47 11.0 24.4 46 4.9 0.2 8.6 8 0 0 8 8 8 0 Leucine Rich Repeat THOC7 PF05615.11 NM_001285780.1_3 - 4e-40 137.0 4.5 4e-39 133.8 0.2 2.1 1 1 1 2 2 2 2 Tho complex subunit 7 UPF0193 PF05250.9 NM_001285780.1_3 - 0.0065 16.2 5.8 0.01 15.5 5.8 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) DASH_Dad2 PF08654.8 NM_001285780.1_3 - 0.094 13.0 0.9 0.23 11.8 1.0 1.6 2 0 0 2 2 2 0 DASH complex subunit Dad2 EcoEI_R_C PF08463.8 NM_001285780.1_3 - 0.19 11.7 4.3 0.31 11.0 4.3 1.2 1 0 0 1 1 1 0 EcoEI R protein C-terminal COG2 PF06148.9 NM_001285780.1_3 - 1.1 9.3 6.1 0.93 9.4 0.6 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.9 NM_001285780.1_3 - 1.2 7.8 14.0 1.2 7.9 3.0 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein FAM165 PF14981.4 NM_138743.2_2 - 1.1e-24 85.8 2.9 2.2e-24 84.9 2.9 1.4 1 0 0 1 1 1 1 FAM165 family CCDC-167 PF15188.4 NM_001163741.2_1 - 8.1e-31 106.1 2.5 1.3e-30 105.5 2.5 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 IncA PF04156.12 NM_001163741.2_1 - 0.055 13.1 5.6 0.12 12.1 5.6 1.4 1 0 0 1 1 1 0 IncA protein E1_dh PF00676.18 NM_001252282.1_1 - 3.7e-99 331.3 0.0 4.9e-99 330.9 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.22 NM_001252282.1_1 - 9.2e-66 220.8 0.0 2.2e-65 219.5 0.0 1.7 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.3 NM_001252282.1_1 - 2.7e-56 189.3 0.0 4.3e-56 188.7 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.3 NM_001252282.1_1 - 1.4e-18 66.1 0.9 4.6e-18 64.4 0.1 2.2 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus CCER1 PF15482.4 NM_001252282.1_1 - 0.13 12.0 1.3 0.31 10.8 1.3 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 RabGAP-TBC PF00566.16 NM_025768.2_2 - 1.6e-55 188.0 0.0 2e-55 187.6 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Mito_carr PF00153.25 NM_001114179.1_3 - 2.3e-22 78.6 0.4 1.2e-07 31.4 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein 7tm_4 PF13853.4 NM_146992.2_1 - 1.8e-48 165.6 17.4 2.1e-48 165.4 17.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146992.2_1 - 1.7e-20 73.3 17.6 3.6e-20 72.2 17.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146992.2_1 - 1.7e-08 34.0 18.1 5.3e-08 32.4 18.1 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx zf-H2C2_2 PF13465.4 NM_009566.5_1 - 3.8e-44 147.1 42.7 7.7e-08 32.3 0.1 10.7 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2 PF00096.24 NM_009566.5_1 - 3.8e-42 140.3 47.9 3.4e-06 27.1 0.3 11.0 9 0 0 9 9 9 8 Zinc finger, C2H2 type KRAB PF01352.25 NM_009566.5_1 - 2.7e-21 74.8 0.6 5.7e-21 73.8 0.6 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_009566.5_1 - 9.7e-17 60.1 68.6 0.029 15.0 0.3 11.4 11 0 0 11 11 9 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_009566.5_1 - 2.7e-15 55.8 38.5 0.0067 16.2 0.2 8.3 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_009566.5_1 - 7.5e-10 38.7 13.6 0.54 10.5 0.0 7.5 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_009566.5_1 - 2e-07 30.9 32.0 0.023 14.7 1.3 6.4 4 1 3 7 7 7 4 Zinc ribbon domain XPA_N PF01286.16 NM_009566.5_1 - 0.0022 17.9 27.9 5.1 7.1 0.2 8.3 8 0 0 8 8 8 1 XPA protein N-terminal DZR PF12773.5 NM_009566.5_1 - 0.031 14.2 26.4 2.9 7.8 4.2 5.3 3 1 1 4 4 3 0 Double zinc ribbon ADK_lid PF05191.12 NM_009566.5_1 - 0.41 10.6 16.9 0.51 10.3 0.9 5.2 5 1 1 6 6 6 0 Adenylate kinase, active site lid PknG_rubred PF16919.3 NM_009566.5_1 - 0.42 10.6 13.5 0.87 9.6 0.1 4.7 3 1 1 5 5 4 0 Protein kinase G rubredoxin domain zf-met PF12874.5 NM_009566.5_1 - 1 9.7 28.6 9.6 6.6 0.2 7.9 7 0 0 7 7 7 0 Zinc-finger of C2H2 type FYVE PF01363.19 NM_009566.5_1 - 3.1 7.9 21.7 43 4.2 9.2 5.1 2 1 1 3 3 2 0 FYVE zinc finger zf-C2HE PF16278.3 NM_009566.5_1 - 6.9 7.1 34.9 35 4.8 2.9 8.3 3 2 3 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3268 PF11672.6 NM_009566.5_1 - 7.5 6.8 10.6 5.6 7.2 0.1 3.7 4 0 0 4 4 4 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 NM_009566.5_1 - 8.7 7.0 29.0 0.92 10.2 0.7 5.5 4 2 2 6 6 4 0 zinc-ribbon family EGF_CA PF07645.13 NM_001037906.2_1 - 7.1e-23 80.4 54.4 1.5e-09 37.8 3.4 10.5 10 1 1 11 11 6 4 Calcium-binding EGF domain VWC PF00093.16 NM_001037906.2_1 - 1.5e-17 63.5 75.7 9.6e-10 38.5 14.1 9.9 6 1 0 7 7 6 5 von Willebrand factor type C domain EGF_3 PF12947.5 NM_001037906.2_1 - 1.6e-11 44.0 36.2 7.6e-09 35.5 15.2 10.6 10 1 0 10 10 8 5 EGF domain cEGF PF12662.5 NM_001037906.2_1 - 3.7e-09 36.2 82.1 3e-06 26.9 3.7 10.6 10 0 0 10 10 10 5 Complement Clr-like EGF-like TILa PF12714.5 NM_001037906.2_1 - 1.3e-06 28.2 5.4 1.3e-06 28.2 5.4 10.8 6 2 7 13 13 7 4 TILa domain Laminin_G_2 PF02210.22 NM_001037906.2_1 - 5e-06 27.0 0.0 8.8e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.4 NM_001037906.2_1 - 3.6e-05 23.8 0.0 5.8e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 NM_001037906.2_1 - 0.00018 21.6 25.7 0.0019 18.3 11.2 11.7 13 0 0 13 13 8 5 EGF-like domain Plasmod_Pvs28 PF06247.9 NM_001037906.2_1 - 0.0007 19.7 18.4 0.0021 18.2 9.3 8.6 7 1 1 8 8 7 4 Pvs28 EGF domain Laminin_G_1 PF00054.21 NM_001037906.2_1 - 0.0012 18.9 0.0 0.0023 18.0 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain EGF_2 PF07974.11 NM_001037906.2_1 - 0.002 18.4 13.7 0.002 18.4 13.7 12.2 11 1 1 12 12 9 3 EGF-like domain hEGF PF12661.5 NM_001037906.2_1 - 0.019 15.5 5.1 0.019 15.5 5.1 12.7 13 1 1 14 14 10 0 Human growth factor-like EGF Telomere_reg-2 PF10193.7 NM_027880.2_1 - 4.4e-35 120.3 0.3 9.8e-35 119.1 0.3 1.6 1 0 0 1 1 1 1 Telomere length regulation protein Tetraspannin PF00335.18 NM_026815.2_2 - 1.4e-25 90.2 6.5 1.8e-25 89.9 6.5 1.1 1 0 0 1 1 1 1 Tetraspanin family zf-H2C2_2 PF13465.4 NM_001005343.2_2 - 9.8e-15 54.1 21.7 1.7e-08 34.4 1.1 4.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001005343.2_2 - 9.9e-13 47.7 28.1 1.2e-05 25.4 1.0 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001005343.2_2 - 6.4e-06 26.4 9.1 0.00016 22.0 1.8 4.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-Di19 PF05605.10 NM_001005343.2_2 - 0.0016 18.6 1.4 0.0016 18.6 1.4 2.4 2 1 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 NM_001005343.2_2 - 0.0085 16.3 4.0 0.95 9.7 0.8 3.5 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001005343.2_2 - 0.0087 15.9 11.0 0.025 14.4 0.7 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.5 NM_001005343.2_2 - 0.011 16.0 8.3 0.089 13.1 1.2 3.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 NM_080433.3_3 - 5.1e-29 99.3 46.6 6.4e-06 26.3 0.2 7.7 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 NM_080433.3_3 - 2.1e-22 78.1 66.0 7.6e-06 26.0 2.1 7.1 7 0 0 7 7 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_080433.3_3 - 6.6e-15 54.4 56.9 0.0049 17.5 0.7 7.1 7 0 0 7 7 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_080433.3_3 - 0.00016 21.4 38.6 0.021 14.6 2.7 6.6 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_080433.3_3 - 0.00019 21.5 38.9 0.56 10.5 1.4 6.5 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_080433.3_3 - 0.17 12.5 17.5 0.99 10.1 0.9 3.5 1 1 1 3 3 3 0 zinc-ribbon family Zn-ribbon_8 PF09723.8 NM_080433.3_3 - 0.38 10.8 26.6 1.1 9.4 2.1 5.2 4 1 1 5 5 5 0 Zinc ribbon domain zf-Di19 PF05605.10 NM_080433.3_3 - 0.83 9.9 31.0 0.19 11.9 6.0 4.5 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.9 NM_080433.3_3 - 0.89 9.3 7.7 21 4.9 0.0 3.8 2 1 2 4 4 4 0 GAGA factor Rep_fac-A_C PF08646.8 NM_080433.3_3 - 5.8 6.5 12.8 3 7.4 1.2 3.0 2 1 1 3 3 3 0 Replication factor-A C terminal domain zf-Sec23_Sec24 PF04810.13 NM_080433.3_3 - 6.5 6.8 23.7 0.88 9.5 2.6 5.3 3 3 2 5 5 5 0 Sec23/Sec24 zinc finger TPR_1 PF00515.26 NM_019795.4_1 - 1.9e-39 131.8 30.0 2.3e-06 27.0 4.3 8.9 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.15 NM_019795.4_1 - 8.1e-38 125.4 23.4 3.6e-06 26.5 1.9 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat DnaJ PF00226.29 NM_019795.4_1 - 9e-24 83.3 2.2 9e-24 83.3 2.2 2.3 2 0 0 2 2 2 1 DnaJ domain TPR_8 PF13181.4 NM_019795.4_1 - 6.9e-22 75.7 17.5 0.0012 18.7 1.4 8.6 8 1 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.4 NM_019795.4_1 - 1.5e-16 59.6 22.4 6.3e-07 28.8 4.4 7.3 5 1 2 7 7 7 4 TPR repeat TPR_19 PF14559.4 NM_019795.4_1 - 2.1e-15 56.8 13.2 0.017 15.5 0.3 6.3 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.4 NM_019795.4_1 - 3.2e-15 55.2 14.0 4e-05 23.6 0.1 7.6 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_12 PF13424.4 NM_019795.4_1 - 6.5e-14 51.9 18.9 1.6e-05 25.0 0.9 6.7 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.4 NM_019795.4_1 - 3.6e-13 49.8 6.5 0.0094 16.5 0.5 6.2 4 2 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_019795.4_1 - 7.7e-11 41.7 6.2 1.1 10.1 0.0 8.3 6 2 3 9 9 8 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_019795.4_1 - 1.6e-08 34.4 9.5 0.89 9.6 0.0 5.6 3 3 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_019795.4_1 - 3.8e-07 29.5 11.5 0.26 11.3 0.2 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_019795.4_1 - 1e-06 28.7 27.0 0.064 13.3 0.2 6.1 1 1 5 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 NM_019795.4_1 - 4.7e-05 23.6 16.6 0.53 10.9 0.5 6.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_10 PF13374.4 NM_019795.4_1 - 0.00011 21.9 17.0 0.92 9.3 0.4 6.4 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_4 PF07721.12 NM_019795.4_1 - 0.041 14.4 0.1 24 5.8 0.0 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat RPT PF13446.4 NM_019795.4_1 - 0.095 12.5 0.0 0.35 10.7 0.0 1.9 1 0 0 1 1 1 0 A repeated domain in UCH-protein Sel1 PF08238.10 NM_019795.4_1 - 0.51 11.0 4.2 4.9 7.8 0.4 3.7 3 0 0 3 3 3 0 Sel1 repeat MIT PF04212.16 NM_019795.4_1 - 0.73 9.8 21.6 0.54 10.3 1.1 5.3 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain RPN7 PF10602.7 NM_019795.4_1 - 0.82 9.2 12.5 0.43 10.1 3.3 2.8 2 1 0 2 2 2 0 26S proteasome subunit RPN7 TPR_3 PF07720.10 NM_019795.4_1 - 3.1 7.8 11.9 0.8 9.6 4.5 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat BTAD PF03704.15 NM_019795.4_1 - 3.9 7.8 10.5 46 4.3 0.1 4.1 1 1 2 4 4 4 0 Bacterial transcriptional activator domain SHNi-TPR PF10516.7 NM_019795.4_1 - 4.2 6.8 7.1 6.9 6.1 0.1 4.5 6 0 0 6 6 5 0 SHNi-TPR V-set PF07686.15 NM_007677.2_3 - 4.4e-36 123.2 0.3 1.5e-09 37.8 0.0 5.1 4 1 1 5 5 5 4 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_007677.2_3 - 8.7e-26 90.2 0.2 9.7e-09 35.6 0.1 4.5 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 NM_007677.2_3 - 9.1e-23 80.0 0.0 6.5e-09 35.6 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.23 NM_007677.2_3 - 2.3e-16 59.6 6.0 1.7e-09 37.6 0.2 4.3 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 NM_007677.2_3 - 3.8e-14 52.7 2.5 7e-07 29.4 0.1 5.0 4 3 0 4 4 4 3 Immunoglobulin domain Receptor_2B4 PF11465.6 NM_007677.2_3 - 6e-05 23.1 0.0 1 9.5 0.0 4.1 4 0 0 4 4 4 2 Natural killer cell receptor 2B4 Invasin_D3 PF09134.8 NM_007677.2_3 - 0.079 12.6 1.0 0.33 10.6 0.1 2.3 2 0 0 2 2 2 0 Invasin, domain 3 FAM27 PF15832.3 NM_001039188.1_1 - 8.8e-05 22.8 2.8 0.00028 21.3 2.8 1.8 1 0 0 1 1 1 1 FAM27 D and E protein family DUF3915 PF13054.4 NM_001039188.1_1 - 0.14 12.0 3.9 0.23 11.3 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 NM_001039188.1_2 - 1.3 8.9 9.3 2.5 8.0 9.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) zf-C2H2 PF00096.24 NM_001039188.1_3 - 3.1e-30 102.8 93.5 9.8e-05 22.5 2.6 12.8 12 0 0 12 12 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001039188.1_3 - 3.1e-27 92.7 88.9 0.0005 20.5 1.0 13.1 12 0 0 12 12 12 11 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_001039188.1_3 - 1.1e-17 63.5 80.2 7.5e-07 29.2 0.1 14.5 14 1 0 14 14 14 6 Zinc-finger double domain zf-H2C2_5 PF13909.4 NM_001039188.1_3 - 4.7e-08 32.5 50.8 4e-07 29.5 0.0 8.7 9 0 0 9 9 9 4 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 NM_001039188.1_3 - 0.001 18.8 0.0 0.001 18.8 0.0 11.6 12 0 0 12 12 12 5 C2H2-type zinc finger FAM27 PF15832.3 NM_001039188.1_3 - 0.0029 18.0 2.2 0.011 16.2 2.2 1.9 1 0 0 1 1 1 1 FAM27 D and E protein family DUF3915 PF13054.4 NM_001039188.1_3 - 0.0051 16.7 1.7 0.011 15.6 1.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) zf-C2H2_8 PF15909.3 NM_001039188.1_3 - 0.0094 16.1 1.1 0.0094 16.1 1.1 4.7 4 0 0 4 4 4 2 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.6 NM_001039188.1_3 - 0.05 13.8 44.1 0.06 13.5 2.0 9.9 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding DUF629 PF04780.10 NM_001039188.1_3 - 0.08 11.3 9.5 1.3 7.3 2.7 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF629) Pkinase_Tyr PF07714.15 NM_001003817.1_3 - 4e-86 288.4 0.0 5.5e-86 287.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 NM_001003817.1_3 - 9.2e-53 177.0 0.0 1.4e-29 102.3 0.0 2.3 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 NM_001003817.1_3 - 5.8e-42 142.5 85.3 4.2e-41 139.7 29.9 3.8 3 1 1 4 4 4 2 Growth factor receptor domain IV Pkinase PF00069.23 NM_001003817.1_3 - 1.4e-36 126.1 0.0 2e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 NM_001003817.1_3 - 1.2e-24 86.7 90.6 1.7e-24 86.3 37.5 4.1 3 1 0 3 3 3 2 Furin-like cysteine rich region APH PF01636.21 NM_001003817.1_3 - 0.015 15.1 0.1 0.032 14.0 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Lamp PF01299.15 NM_001003817.1_3 - 0.053 12.9 1.2 0.087 12.2 1.2 1.2 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) EphA2_TM PF14575.4 NM_001003817.1_3 - 0.13 12.9 0.2 0.3 11.8 0.2 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain BAG PF02179.14 NM_013863.5_1 - 3.7e-18 65.6 3.9 5.6e-18 65.0 3.9 1.3 1 0 0 1 1 1 1 BAG domain WW PF00397.24 NM_013863.5_1 - 3.4e-10 39.6 1.7 7e-10 38.5 1.7 1.6 1 0 0 1 1 1 1 WW domain Borealin PF10512.7 NM_026560.4_2 - 6.6e-27 93.7 0.3 1.4e-26 92.6 0.3 1.6 1 0 0 1 1 1 1 Cell division cycle-associated protein 8 Nbl1_Borealin_N PF10444.7 NM_026560.4_2 - 3e-18 65.1 0.4 4.6e-17 61.3 0.3 2.3 2 0 0 2 2 2 1 Nbl1 / Borealin N terminal CoaE PF01121.18 NM_026551.3_2 - 1.5e-60 203.8 0.0 1.9e-60 203.4 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.4 NM_026551.3_2 - 0.00086 19.7 0.3 0.0024 18.3 0.3 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.4 NM_026551.3_2 - 0.058 13.4 0.0 0.18 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain Beta_helix PF13229.4 NM_001033162.2_1 - 6.5e-13 48.7 5.3 3.5e-12 46.3 5.3 1.9 1 1 0 1 1 1 1 Right handed beta helix region NosD PF05048.11 NM_001033162.2_1 - 1.1e-08 34.5 1.1 2.3e-08 33.5 1.1 1.4 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) PRY PF13765.4 NM_013848.2_3 - 3.6e-23 80.8 0.3 9.4e-23 79.5 0.3 1.8 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 NM_013848.2_3 - 5.6e-16 58.6 0.1 9.9e-16 57.8 0.1 1.3 1 0 0 1 1 1 1 SPRY domain V-set PF07686.15 NM_013848.2_3 - 1.1e-08 35.1 0.0 3.1e-08 33.6 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.14 NM_013848.2_3 - 4.3e-05 23.4 0.0 0.00092 19.1 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_013848.2_3 - 6.6e-05 23.3 0.0 0.0022 18.4 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 NM_013848.2_3 - 0.0024 18.1 0.0 0.012 15.8 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 NM_013848.2_3 - 0.01 15.9 0.0 0.033 14.2 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin domain FGGY_C PF02782.14 NM_001199568.1_1 - 2.9e-19 69.5 0.0 4.7e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.19 NM_001199568.1_1 - 2.3e-06 27.2 0.0 4.8e-05 22.9 0.0 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, N-terminal domain COX8 PF02285.13 NM_001199568.1_3 - 0.41 10.4 1.8 0.42 10.4 0.1 1.9 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIII Peptidase_C1 PF00112.21 NM_001312649.1_1 - 1.4e-79 267.2 2.6 1.8e-79 266.8 2.6 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.13 NM_001312649.1_1 - 4.4e-05 22.3 3.2 0.0037 16.0 0.3 2.3 2 1 0 2 2 2 2 Peptidase C1-like family DENN PF02141.19 NM_001081066.1_1 - 2.3e-50 171.0 3.4 4.9e-50 169.9 3.4 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.17 NM_001081066.1_1 - 1.5e-05 24.8 1.0 3.7e-05 23.5 1.0 1.7 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.16 NM_001081066.1_1 - 0.00042 20.9 0.0 0.0019 18.8 0.0 2.1 1 0 0 1 1 1 1 uDENN domain Avl9 PF09794.7 NM_001081066.1_1 - 0.0067 15.0 0.0 0.024 13.2 0.0 1.7 1 1 1 2 2 2 1 Transport protein Avl9 WD40 PF00400.30 NM_001081066.1_1 - 0.052 14.3 3.4 2.3 9.1 0.1 4.7 4 0 0 4 4 4 0 WD domain, G-beta repeat Reg_prop PF07494.9 NM_001081066.1_1 - 0.15 12.2 0.2 12 6.4 0.0 3.3 3 0 0 3 3 3 0 Two component regulator propeller DUF4401 PF14351.4 NM_001081066.1_1 - 3.3 6.8 7.0 0.11 11.6 1.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4401) 5-nucleotidase PF06189.10 NM_001085502.1_3 - 4.3e-107 356.9 0.0 9.6e-106 352.4 0.0 2.0 1 1 1 2 2 2 2 5'-nucleotidase SPRY PF00622.26 NM_011791.3_1 - 4.2e-13 49.4 0.2 1.8e-05 24.7 0.0 2.5 2 0 0 2 2 2 2 SPRY domain PHD20L1_u1 PF16660.3 NM_011791.3_1 - 0.51 11.0 2.2 1.3 9.7 2.2 1.6 1 0 0 1 1 1 0 PHD finger protein 20-like protein 1 DCX PF03607.15 NM_001195730.1_1 - 1.1e-37 127.8 0.0 2.3e-19 69.1 0.0 2.3 2 0 0 2 2 2 2 Doublecortin RRM_1 PF00076.20 NM_001271447.1_1 - 2e-08 33.8 0.0 4.2e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001271447.1_1 - 0.045 13.7 0.2 0.33 11.0 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif Proteasome PF00227.24 NM_011967.3_1 - 1.6e-55 187.4 0.1 2e-55 187.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 NM_011967.3_1 - 1.3e-13 50.2 0.0 2.4e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature E2F_CC-MB PF16421.3 NM_033270.2_1 - 4.4e-31 107.1 0.4 7.5e-31 106.3 0.4 1.4 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.18 NM_033270.2_1 - 2.4e-23 81.8 0.2 1.3e-22 79.5 0.1 2.3 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.17 NM_033270.2_1 - 0.092 12.5 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB FerA PF08165.9 NM_033270.2_1 - 0.19 11.5 2.2 1.9 8.4 0.6 2.3 2 0 0 2 2 2 0 FerA (NUC095) domain F-box-like PF12937.5 NM_199036.2_3 - 9.2e-11 41.3 0.4 9.2e-11 41.3 0.4 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 NM_199036.2_3 - 4.7e-07 29.4 0.1 1.1e-06 28.2 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.3 NM_199036.2_3 - 0.0085 15.8 0.6 0.0085 15.8 0.6 2.2 4 0 0 4 4 4 1 F-box Cadherin PF00028.15 NM_009959.1_1 - 1e-72 240.5 0.0 9.9e-16 57.8 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 NM_009959.1_1 - 4e-63 211.5 4.7 7.7e-63 210.6 4.7 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 NM_009959.1_1 - 1.5e-31 107.9 4.8 5.4e-29 99.7 0.1 4.4 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 NM_009959.1_1 - 4.6e-06 27.2 0.2 2.1e-05 25.1 0.1 2.2 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal ARID PF01388.19 NM_001288626.1_3 - 8.3e-20 71.1 0.0 1.5e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain TRAP_alpha PF03896.14 NM_001288626.1_3 - 1.2 8.1 2.7 2.5 7.1 2.7 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.10 NM_001288626.1_3 - 5 5.1 9.7 9 4.2 9.7 1.3 1 0 0 1 1 1 0 Nop14-like family TFIIA PF03153.11 NM_001288626.1_3 - 5.1 6.8 13.8 5.3 6.8 3.4 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RNA_pol_3_Rpc31 PF11705.6 NM_001288626.1_3 - 8.1 6.5 15.8 0.057 13.5 7.4 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 PQ-loop PF04193.12 NM_001301710.1_1 - 8.8e-13 47.7 0.4 1.6e-12 46.8 0.4 1.4 1 0 0 1 1 1 1 PQ loop repeat RPS31 PF17067.3 NM_001301710.1_2 - 5.1 7.2 8.4 6 7.0 2.1 2.9 2 2 0 2 2 2 0 Ribosomal protein S31e PQ-loop PF04193.12 NM_001301710.1_3 - 9.7e-06 25.1 0.0 1.8e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 PQ loop repeat DUF3915 PF13054.4 NM_178893.4_1 - 0.5 10.2 9.4 0.85 9.5 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 NM_178893.4_2 - 0.039 13.8 4.9 0.068 13.0 4.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF1899 PF08953.9 NM_178893.4_3 - 4.5e-30 103.2 0.1 7.6e-30 102.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 NM_178893.4_3 - 6e-20 70.7 0.0 1.1e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 NM_178893.4_3 - 2.1e-12 47.2 7.9 0.0001 22.9 0.1 4.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_178893.4_3 - 0.00035 20.7 0.0 0.048 13.8 0.0 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF3915 PF13054.4 NM_178893.4_3 - 0.00078 19.3 2.1 0.0015 18.4 2.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) SPRY PF00622.26 NM_001306052.1_1 - 9.1e-19 67.6 0.0 1.3e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 SPRY domain SOCS_box PF07525.14 NM_001306052.1_1 - 5.2e-12 45.8 3.2 1.1e-11 44.8 3.2 1.5 1 0 0 1 1 1 1 SOCS box YEATS PF03366.14 NM_001145931.1_1 - 2.6e-24 84.9 1.8 4.8e-24 84.0 0.8 2.0 2 0 0 2 2 2 1 YEATS family Fe_hyd_lg_C PF02906.12 NM_026272.3_3 - 3.8e-67 226.4 0.0 5.5e-67 225.8 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.15 NM_026272.3_3 - 3.7e-08 33.2 0.0 7.2e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Iron hydrogenase small subunit Per1 PF04080.11 NM_001033537.2_3 - 7e-92 307.6 14.5 9.3e-92 307.2 14.5 1.2 1 0 0 1 1 1 1 Per1-like PIG-P PF08510.10 NM_001159617.1_1 - 5.1e-40 136.0 2.5 6.5e-40 135.7 2.5 1.1 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.10 NM_001159617.1_1 - 0.0017 18.5 6.5 0.0028 17.8 6.5 1.3 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Phage_holin_3_6 PF07332.9 NM_001159617.1_1 - 0.18 11.7 0.6 0.29 11.1 0.6 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Toxin_22 PF08092.9 NM_001159617.1_2 - 0.14 12.1 1.2 0.41 10.6 1.2 1.8 1 0 0 1 1 1 0 Magi peptide toxin family Pyridoxal_deC PF00282.17 NM_016672.4_2 - 2e-171 569.6 0.0 2.5e-171 569.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.19 NM_016672.4_2 - 9.3e-07 28.3 0.0 2.3e-06 27.0 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.19 NM_016672.4_2 - 0.01 14.9 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II SWIM PF04434.15 NM_172503.3_3 - 0.29 10.7 2.7 0.77 9.4 2.7 1.8 1 0 0 1 1 1 0 SWIM zinc finger Cadherin PF00028.15 NM_053142.3_1 - 4.8e-79 260.8 0.1 3.5e-17 62.5 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_053142.3_1 - 6.9e-36 121.8 3.7 8.8e-34 115.0 0.1 4.5 5 1 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 NM_053142.3_1 - 1.4e-25 89.8 0.2 2.9e-25 88.7 0.2 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Takusan PF04822.11 NM_001281516.1_1 - 2.6e-23 81.6 9.1 2.6e-23 81.6 9.1 1.9 2 0 0 2 2 2 1 Takusan DUF3473 PF11959.6 NM_001281516.1_1 - 0.0067 16.3 0.3 0.011 15.6 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3473) RFX_DNA_binding PF02257.13 NM_001145660.1_3 - 1.1e-28 99.5 1.2 3.3e-28 98.0 0.0 2.2 2 0 0 2 2 2 1 RFX DNA-binding domain zf-DHHC PF01529.18 NM_175358.4_2 - 1.1e-33 116.0 20.9 1.1e-33 116.0 20.9 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Neur_chan_LBD PF02931.21 NM_146017.3_1 - 2.8e-47 160.8 0.0 4.3e-47 160.2 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 NM_146017.3_1 - 8.4e-24 84.8 5.1 9.5e-22 78.1 1.8 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Pkinase PF00069.23 NM_001310704.1_1 - 1.5e-24 86.6 0.0 2.3e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001310704.1_1 - 6.3e-14 51.7 0.0 2e-13 50.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase 7tm_4 PF13853.4 NM_146327.2_3 - 2.3e-55 188.2 9.8 3.3e-55 187.7 9.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146327.2_3 - 1e-21 77.3 16.7 1.3e-20 73.7 16.7 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146327.2_3 - 6.4e-05 22.3 14.2 0.00012 21.4 14.2 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 NM_146327.2_3 - 0.0024 17.1 2.0 0.0024 17.1 2.0 2.5 2 2 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv Mito_carr PF00153.25 NM_177809.4_1 - 2.6e-58 193.8 3.9 2.4e-21 75.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.17 NM_177809.4_1 - 3.8 7.8 6.2 27 5.0 0.3 3.2 2 1 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family ANF_receptor PF01094.26 NM_013540.2_3 - 7.5e-59 199.5 0.0 1.2e-58 198.8 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 NM_013540.2_3 - 5.5e-58 194.9 0.1 1.2e-57 193.8 0.1 1.6 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 NM_013540.2_3 - 3e-45 152.9 0.2 7.2e-45 151.7 0.1 1.7 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 NM_013540.2_3 - 8.6e-24 84.1 0.0 1.4e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 zf-AN1 PF01428.14 NM_148926.2_2 - 1.8e-07 31.0 7.9 1.8e-07 31.0 7.9 2.6 2 0 0 2 2 2 1 AN1-like Zinc finger zf-A20 PF01754.14 NM_148926.2_2 - 2.2e-05 24.1 6.5 6.8e-05 22.6 6.5 1.9 1 0 0 1 1 1 1 A20-like zinc finger LRR_8 PF13855.4 NM_199065.2_3 - 6.1e-45 150.7 37.5 6.1e-13 48.2 2.3 6.6 2 2 4 6 6 6 6 Leucine rich repeat LRR_5 PF13306.4 NM_199065.2_3 - 8.4e-15 54.7 0.1 1.9e-06 27.7 0.1 2.4 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 NM_199065.2_3 - 5e-12 45.6 51.1 0.015 15.5 7.5 8.6 5 2 2 9 9 9 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_199065.2_3 - 0.00015 21.2 19.6 0.016 14.6 1.0 4.2 2 2 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.31 NM_199065.2_3 - 0.95 10.1 37.1 10 6.9 2.7 10.4 11 1 0 11 11 11 0 Leucine Rich Repeat LRRNT PF01462.16 NM_199065.2_3 - 6 6.5 17.8 0.54 9.8 2.9 3.6 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain IRK PF01007.18 NM_001039056.2_1 - 1.4e-135 451.4 2.7 1.9e-135 451.0 2.7 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 NM_001039056.2_1 - 0.016 15.0 3.8 0.046 13.6 3.8 1.8 1 0 0 1 1 1 0 Ion channel DUF2182 PF09948.7 NM_001039056.2_1 - 0.069 12.9 0.4 0.17 11.6 0.4 1.6 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) HD-ZIP_N PF04618.10 NM_001039056.2_1 - 0.16 12.4 0.3 7.9 6.9 0.0 2.5 2 0 0 2 2 2 0 HD-ZIP protein N terminus HD-ZIP_N PF04618.10 NM_001039056.2_2 - 1.3 9.4 9.5 6.2 7.3 0.1 3.5 3 0 0 3 3 3 0 HD-ZIP protein N terminus INCENP_ARK-bind PF03941.13 NM_016692.3_3 - 9.6e-20 70.1 0.1 2.3e-19 68.9 0.1 1.7 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region INCENP_N PF12178.6 NM_016692.3_3 - 1.2e-15 57.0 0.1 3.5e-15 55.5 0.1 1.9 1 0 0 1 1 1 1 Chromosome passenger complex (CPC) protein INCENP N terminal Ion_trans PF00520.29 NM_008418.2_1 - 4.2e-52 176.7 5.5 5.5e-52 176.3 5.5 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_008418.2_1 - 6.7e-28 96.8 0.0 1.1e-27 96.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 NM_008418.2_1 - 1.3e-13 50.6 5.2 1.3e-13 50.6 5.2 2.3 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.10 NM_008418.2_1 - 0.0067 15.0 0.7 0.011 14.3 0.7 1.3 1 0 0 1 1 1 1 Polycystin cation channel FoP_duplication PF13865.4 NM_008418.2_2 - 9.9 6.7 6.9 23 5.5 6.9 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 COMM_domain PF07258.12 NM_001033132.3_3 - 5.8e-16 58.2 0.0 8.8e-16 57.7 0.0 1.3 1 0 0 1 1 1 1 COMM domain SF3a60_bindingd PF12108.6 NM_001033132.3_3 - 0.16 11.7 2.1 0.39 10.5 2.1 1.6 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain UCH PF00443.27 NM_133758.3_2 - 8.1e-49 166.3 0.5 8.1e-49 166.3 0.5 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_133758.3_2 - 7.1e-30 104.5 0.2 7.1e-30 104.5 0.2 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_2 PF14560.4 NM_133758.3_2 - 3.1e-05 24.2 0.0 1.1 9.6 0.0 4.0 3 0 0 3 3 3 2 Ubiquitin-like domain ubiquitin PF00240.21 NM_133758.3_2 - 0.0011 18.6 0.0 0.19 11.4 0.0 3.5 3 0 0 3 3 3 1 Ubiquitin family Sad1_UNC PF07738.11 NM_133758.3_2 - 0.099 12.5 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal HLH PF00010.24 NM_008213.2_2 - 3.1e-16 59.0 0.1 5.1e-16 58.2 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Steroid_dh PF02544.14 NM_020611.4_2 - 8.6e-20 71.1 10.4 8.6e-20 71.1 10.4 1.7 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase I-set PF07679.14 NM_029967.3_3 - 1e-47 160.0 0.0 1.2e-13 50.8 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_029967.3_3 - 4.1e-46 155.4 0.1 2.7e-13 50.2 0.0 5.1 5 0 0 5 5 5 4 Immunoglobulin domain TSP_1 PF00090.17 NM_029967.3_3 - 9.2e-40 134.5 161.8 1e-05 25.5 1.7 15.6 13 1 1 14 14 14 11 Thrombospondin type 1 domain Ig_2 PF13895.4 NM_029967.3_3 - 2.1e-31 108.0 0.0 1.2e-07 31.8 0.0 5.1 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 NM_029967.3_3 - 2.9e-25 88.1 0.0 7.5e-08 32.3 0.2 4.6 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 NM_029967.3_3 - 2.5e-12 46.8 1.3 0.0038 17.2 0.2 6.4 5 2 1 6 6 6 2 Immunoglobulin V-set domain PLAC PF08686.9 NM_029967.3_3 - 1.3e-06 28.8 11.9 1.9e-06 28.3 8.9 3.2 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain ADAM_spacer1 PF05986.12 NM_029967.3_3 - 0.0022 17.9 0.0 0.0038 17.1 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Adeno_E3_CR1 PF02440.13 NM_029967.3_3 - 0.016 14.9 1.1 0.067 12.9 0.0 2.5 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 Peptidase_M19 PF01244.19 NM_176913.4_3 - 5.7e-102 341.0 0.0 8.9e-102 340.4 0.0 1.3 1 1 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Pyr_excise PF03013.12 NM_176913.4_3 - 0.092 12.6 0.0 20 5.0 0.0 3.3 3 0 0 3 3 3 0 Pyrimidine dimer DNA glycosylase NEMP PF10225.7 NM_173732.3_1 - 4.8e-60 203.3 16.6 9.7e-60 202.2 16.6 1.5 1 0 0 1 1 1 1 NEMP family DUF2207 PF09972.7 NM_173732.3_1 - 9.2 4.8 7.6 4.1 5.9 5.5 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) 7tm_4 PF13853.4 NM_001011807.2_1 - 1.2e-46 159.6 21.0 1.4e-46 159.4 21.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011807.2_1 - 1.1e-15 57.4 20.7 2.1e-15 56.5 20.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MBOAT_2 PF13813.4 NM_001011807.2_1 - 0.33 11.1 6.2 3.1 8.0 0.0 3.7 2 1 2 4 4 4 0 Membrane bound O-acyl transferase family Arm_2 PF04826.11 NM_001166397.1_1 - 4.6e-106 353.8 8.8 5.7e-106 353.5 8.8 1.1 1 0 0 1 1 1 1 Armadillo-like Atx10homo_assoc PF09759.7 NM_001166397.1_1 - 0.00012 22.0 0.4 0.00048 20.0 0.4 1.9 1 1 1 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.21 NM_001166397.1_1 - 0.00068 19.5 0.1 0.15 12.0 0.0 2.6 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat V-ATPase_H_C PF11698.6 NM_001166397.1_1 - 0.0053 16.7 0.1 0.012 15.6 0.1 1.6 1 0 0 1 1 1 1 V-ATPase subunit H Cnd1 PF12717.5 NM_001166397.1_1 - 0.01 15.7 1.0 0.017 15.0 1.0 1.3 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 NM_001166397.1_1 - 0.071 13.3 0.0 0.89 9.8 0.0 2.5 2 0 0 2 2 2 0 HEAT repeat CDC37_M PF08565.9 NM_016742.4_2 - 5.8e-27 93.8 1.1 9.9e-27 93.1 0.8 1.6 1 1 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.8 NM_016742.4_2 - 4.4e-15 55.5 0.0 4.4e-15 55.5 0.0 3.0 3 1 0 3 3 3 1 Cdc37 C terminal domain CDC37_N PF03234.12 NM_016742.4_2 - 7.1e-14 52.7 16.4 7.1e-14 52.7 16.4 2.4 2 1 1 3 3 3 1 Cdc37 N terminal kinase binding Med4 PF10018.7 NM_016742.4_2 - 0.044 13.3 11.2 0.038 13.5 2.0 2.4 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Atg14 PF10186.7 NM_016742.4_2 - 1.9 7.4 10.0 3 6.7 10.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TBPIP PF07106.11 NM_016742.4_2 - 4.3 6.9 16.3 0.23 11.1 10.0 2.0 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) CRT10 PF08728.8 NM_016742.4_2 - 4.6 5.2 8.7 6.9 4.6 8.7 1.1 1 0 0 1 1 1 0 CRT10 Abhydrolase_6 PF12697.5 NM_028292.2_2 - 2.3e-26 93.6 0.0 5e-26 92.5 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 NM_028292.2_2 - 1.3e-14 54.4 0.0 1.9e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 NM_028292.2_2 - 1.5e-10 40.7 0.1 2.5e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.18 NM_028292.2_2 - 3.1e-05 24.1 0.0 5.1e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.18 NM_028292.2_2 - 0.0052 16.3 0.1 0.012 15.1 0.1 1.5 1 1 0 1 1 1 1 Putative esterase PGAP1 PF07819.11 NM_028292.2_2 - 0.0061 16.2 0.1 0.0098 15.5 0.1 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_3 PF07859.11 NM_028292.2_2 - 0.027 14.2 0.1 0.047 13.4 0.1 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.14 NM_028292.2_2 - 0.087 12.5 0.8 10 5.7 0.1 2.7 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.23 NM_028292.2_2 - 0.12 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) NACHT PF05729.10 NM_175532.3_2 - 1.2e-34 119.4 0.0 2e-34 118.8 0.0 1.3 1 0 0 1 1 1 1 NACHT domain PYRIN PF02758.14 NM_175532.3_2 - 3.7e-16 58.9 0.6 8.4e-16 57.8 0.6 1.6 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain NB-ARC PF00931.20 NM_175532.3_2 - 0.0057 15.6 0.0 0.02 13.8 0.0 1.8 1 1 0 1 1 1 1 NB-ARC domain AAA_30 PF13604.4 NM_175532.3_2 - 0.0063 16.1 0.0 0.0097 15.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 NM_175532.3_2 - 0.0088 16.3 0.0 0.043 14.1 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.4 NM_175532.3_2 - 0.074 13.1 0.2 0.14 12.2 0.2 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.4 NM_175532.3_2 - 0.084 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.15 NM_175532.3_2 - 0.089 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.27 NM_175532.3_2 - 0.12 12.7 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.20 NM_175532.3_2 - 0.13 12.5 0.3 0.44 10.8 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_19 PF13245.4 NM_175532.3_2 - 0.15 12.2 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.17 NM_175532.3_2 - 0.18 11.2 0.1 0.32 10.4 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain zf-3CxxC PF13695.4 NM_174877.3_1 - 2.4e-08 34.2 15.4 3.7e-08 33.6 15.4 1.3 1 0 0 1 1 1 1 Zinc-binding domain zf-3CxxC_2 PF17180.2 NM_174877.3_1 - 6.9e-05 23.3 17.9 0.00019 22.0 17.9 1.8 1 1 0 1 1 1 1 Zinc-binding domain Zfx_Zfy_act PF04704.11 NM_001044386.1_3 - 2.7e-150 499.9 20.2 4e-150 499.4 20.2 1.2 1 0 0 1 1 1 1 Zfx / Zfy transcription activation region zf-C2H2 PF00096.24 NM_001044386.1_3 - 5.1e-36 121.0 113.0 3e-05 24.1 2.1 13.9 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001044386.1_3 - 3.5e-30 103.0 123.2 9.7e-08 32.0 1.3 14.0 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001044386.1_3 - 1.2e-23 81.6 112.2 0.00041 20.8 0.9 14.3 14 0 0 14 14 14 12 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_001044386.1_3 - 2.8e-23 81.2 95.9 4.2e-06 26.3 4.8 12.3 12 0 0 12 12 12 8 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 NM_001044386.1_3 - 2.8e-08 33.7 73.1 0.099 12.8 0.1 12.0 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_001044386.1_3 - 4.9e-05 23.9 46.9 0.1 13.2 2.2 7.6 5 1 2 7 7 7 4 zinc-ribbon family zf-C2H2_11 PF16622.3 NM_001044386.1_3 - 0.00018 21.1 53.7 0.061 13.0 0.3 9.1 9 0 0 9 9 9 6 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 NM_001044386.1_3 - 5.7 6.9 67.2 0.042 13.7 3.1 9.4 9 0 0 9 9 9 0 C2H2-type zinc finger zf-met PF12874.5 NM_001044386.1_3 - 7.3 7.0 66.8 1.1 9.6 0.0 11.0 11 1 0 11 11 11 0 Zinc-finger of C2H2 type GST_N_3 PF13417.4 NM_026619.2_2 - 4.3e-17 62.1 0.1 8.5e-17 61.2 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 NM_026619.2_2 - 3.6e-12 46.3 0.0 6e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 NM_026619.2_2 - 4.8e-12 45.9 0.0 4.8e-12 45.9 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.22 NM_026619.2_2 - 1.9e-05 24.7 0.0 4.4e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_C_2 PF13410.4 NM_026619.2_2 - 8.7e-05 22.3 0.0 0.00018 21.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_026619.2_2 - 0.013 15.6 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_010357.3_3 - 2.2e-19 69.4 0.0 3.9e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 NM_010357.3_3 - 4.7e-18 65.1 0.0 7.7e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 NM_010357.3_3 - 8.6e-18 64.3 0.0 1.5e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 NM_010357.3_3 - 0.0042 16.9 0.0 0.016 15.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 NM_010357.3_3 - 0.0052 17.0 0.0 0.017 15.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain LRR_8 PF13855.4 NM_008340.3_1 - 9.7e-93 303.8 62.1 3.2e-17 61.9 0.2 9.5 2 2 7 9 9 9 9 Leucine rich repeat LRR_4 PF12799.5 NM_008340.3_1 - 8.1e-38 127.6 52.7 9.4e-05 22.6 0.0 12.2 9 3 2 11 11 11 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 NM_008340.3_1 - 3.1e-22 78.8 0.0 1.5e-05 24.8 0.0 4.1 1 1 2 4 4 4 4 Leucine rich repeats (6 copies) LRR_9 PF14580.4 NM_008340.3_1 - 4.2e-15 55.5 8.4 0.0064 15.9 0.1 6.4 1 1 7 8 8 8 8 Leucine-rich repeat LRR_1 PF00560.31 NM_008340.3_1 - 2.6e-11 42.2 58.4 1.9 9.2 0.5 18.5 17 2 1 18 18 18 2 Leucine Rich Repeat LRRNT PF01462.16 NM_008340.3_1 - 3.9e-09 35.8 4.6 3.9e-09 35.8 1.3 2.8 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain VIR_N PF15912.3 NM_008340.3_1 - 0.088 12.4 0.8 4.7 6.7 0.0 3.1 4 0 0 4 4 4 0 Virilizer, N-terminal Herpes_BTRF1 PF04682.10 NM_008340.3_1 - 0.19 10.9 0.1 0.41 9.8 0.1 1.5 1 0 0 1 1 1 0 Herpesvirus BTRF1 protein conserved region SWIM PF04434.15 NM_008340.3_1 - 4.2 7.0 5.4 6 6.5 0.0 2.5 2 0 0 2 2 2 0 SWIM zinc finger Homeobox PF00046.27 NM_001004193.2_1 - 2.1e-18 65.8 5.2 3.1e-18 65.2 5.2 1.3 1 0 0 1 1 1 1 Homeobox domain Collagen PF01391.16 NM_001004193.2_1 - 0.0018 17.9 14.0 0.0018 17.9 14.0 2.8 3 0 0 3 3 3 1 Collagen triple helix repeat (20 copies) Homeobox_KN PF05920.9 NM_001004193.2_1 - 0.009 15.8 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.3 NM_001004193.2_1 - 0.051 13.3 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DUF902 PF06001.11 NM_001004193.2_3 - 0.12 12.7 1.8 0.24 11.8 0.2 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF902) Pkinase PF00069.23 NM_133741.2_3 - 6.7e-73 245.2 0.0 9.4e-73 244.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_133741.2_3 - 8.4e-40 136.5 0.0 1.2e-39 136.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_133741.2_3 - 7.6e-09 35.2 0.0 2.6e-08 33.4 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 NM_133741.2_3 - 0.036 13.3 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ATP1G1_PLM_MAT8 PF02038.14 NM_052991.4_1 - 1.8e-27 94.3 0.2 2.6e-27 93.8 0.2 1.2 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family Glypican PF01153.17 NM_175500.4_1 - 1.9e-171 571.5 0.0 2.5e-171 571.1 0.0 1.0 1 0 0 1 1 1 1 Glypican 7tm_1 PF00001.19 NM_010323.2_2 - 1.2e-38 132.8 13.8 1.9e-38 132.1 13.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) bZIP_1 PF00170.19 NM_001271503.1_1 - 4.3e-20 71.5 10.5 7.3e-20 70.7 10.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.15 NM_001271503.1_1 - 5.7e-18 64.0 2.3 1.1e-17 63.1 2.3 1.4 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.13 NM_001271503.1_1 - 9.8e-07 28.6 11.2 1.7e-06 27.9 11.2 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001271503.1_1 - 0.47 10.9 11.7 0.031 14.7 6.4 1.6 2 0 0 2 2 2 0 bZIP Maf transcription factor Prokineticin PF06607.9 NM_001170419.1_1 - 1.1e-11 44.7 3.4 1.3e-10 41.3 1.0 2.2 1 1 1 2 2 2 2 Prokineticin Sec7 PF01369.18 NM_001114664.2_2 - 9.8e-56 188.2 0.0 1.7e-55 187.5 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain IQ_SEC7_PH PF16453.3 NM_001114664.2_2 - 1.8e-51 173.6 0.4 4.1e-51 172.5 0.2 1.8 2 0 0 2 2 2 1 PH domain SlyX PF04102.10 NM_001114664.2_2 - 0.25 11.8 5.3 1.4 9.5 5.3 2.4 1 0 0 1 1 1 0 SlyX Atg14 PF10186.7 NM_001114664.2_2 - 1.2 8.0 5.2 2.7 6.8 5.2 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3338 PF11819.6 NM_172475.3_3 - 1.4e-58 196.6 5.2 1.4e-58 196.6 5.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3338) FERM_C PF09380.8 NM_172475.3_3 - 2.3e-23 82.2 0.4 4.6e-23 81.3 0.4 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 NM_172475.3_3 - 5.4e-20 71.8 1.2 1.7e-19 70.2 0.1 2.4 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.8 NM_172475.3_3 - 1.2e-13 50.7 0.4 2.7e-13 49.5 0.4 1.6 1 0 0 1 1 1 1 FERM N-terminal domain p450 PF00067.20 NM_019792.2_3 - 3.7e-127 424.7 0.3 4.3e-127 424.5 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1869 PF08956.8 NM_019792.2_3 - 0.11 12.3 0.0 3.8 7.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1869) DEAD PF00270.27 NM_138669.1_3 - 5.5e-42 143.4 0.2 8.7e-42 142.7 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_138669.1_3 - 8.7e-32 109.7 0.0 3.4e-31 107.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_138669.1_3 - 0.00028 20.8 0.0 0.00057 19.8 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 NM_138669.1_3 - 0.00031 21.0 0.0 0.0027 17.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 NM_138669.1_3 - 0.00032 20.3 0.0 0.00052 19.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain UTP25 PF06862.10 NM_138669.1_3 - 0.011 14.4 0.0 1.6 7.2 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.4 NM_138669.1_3 - 0.07 13.3 0.1 0.47 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Flavi_DEAD PF07652.12 NM_138669.1_3 - 0.13 12.1 0.1 0.36 10.6 0.1 1.9 1 1 0 1 1 1 0 Flavivirus DEAD domain Clathrin PF00637.18 NM_172120.4_1 - 6.9e-27 93.9 1.3 6.9e-27 93.9 1.3 2.6 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_1 PF10366.7 NM_172120.4_1 - 0.00018 21.6 6.3 0.0016 18.6 0.1 3.1 2 1 1 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.7 NM_172120.4_1 - 0.0011 19.2 0.3 0.0042 17.3 0.3 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 ANAPC4_WD40 PF12894.5 NM_172120.4_1 - 0.0012 18.9 0.1 0.72 10.1 0.0 3.0 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_5 PF14634.4 NM_172120.4_1 - 0.0033 17.2 4.0 0.01 15.6 4.0 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.5 NM_172120.4_1 - 0.16 12.2 2.9 0.61 10.3 2.9 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.4 NM_172120.4_1 - 0.19 11.9 10.8 0.032 14.4 6.0 2.4 2 0 0 2 2 2 0 Ring finger domain PHD PF00628.27 NM_172120.4_1 - 0.41 10.4 2.9 1.4 8.7 2.9 2.0 1 0 0 1 1 1 0 PHD-finger zf-RING_11 PF17123.3 NM_172120.4_1 - 1.7 8.3 8.3 0.45 10.2 4.4 2.2 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_UBOX PF13445.4 NM_172120.4_1 - 2 8.4 5.8 4.3 7.3 4.8 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3H2C3 PF17122.3 NM_172120.4_1 - 2.7 8.0 7.1 0.19 11.7 1.2 2.2 2 0 0 2 2 2 0 Zinc-finger zf-C3HC4_2 PF13923.4 NM_172120.4_1 - 5.1 6.9 8.7 1.1 9.0 3.1 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Arf PF00025.19 NM_007478.3_1 - 3.6e-77 257.6 0.1 5.1e-77 257.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 NM_007478.3_1 - 2.4e-13 49.8 0.0 3.2e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 NM_007478.3_1 - 9.7e-13 48.3 0.0 1.4e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 NM_007478.3_1 - 1.9e-11 43.7 0.0 2.5e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 NM_007478.3_1 - 1.4e-09 37.5 1.2 1.3e-06 27.7 0.2 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 NM_007478.3_1 - 1.9e-09 37.1 0.0 2.7e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 NM_007478.3_1 - 0.0005 20.0 0.0 0.00071 19.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 NM_007478.3_1 - 0.16 11.1 0.4 0.27 10.4 0.1 1.4 2 0 0 2 2 2 0 6-phosphofructo-2-kinase zf-RING_4 PF14570.4 NM_001164411.1_2 - 2.2e-19 68.8 12.2 2.2e-19 68.8 12.2 2.3 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.20 NM_001164411.1_2 - 3e-05 23.6 0.0 5.8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-UDP PF14569.4 NM_001164411.1_2 - 0.4 10.7 6.0 0.54 10.3 4.5 2.0 1 1 0 1 1 1 0 Zinc-binding RING-finger Ribosomal_L29 PF00831.21 NM_025592.3_1 - 1.6e-20 72.7 2.2 1.6e-20 72.7 2.2 2.5 2 1 1 3 3 3 1 Ribosomal L29 protein XFP_N PF09364.8 NM_025592.3_1 - 0.12 11.0 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 XFP N-terminal domain zf-H2C2_2 PF13465.4 NM_153063.3_1 - 1.1e-66 218.4 115.8 2.4e-09 37.1 0.3 14.1 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2 PF00096.24 NM_153063.3_1 - 8.3e-28 95.1 124.4 6e-05 23.1 3.9 14.1 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_153063.3_1 - 3.1e-27 92.7 119.3 0.00084 19.8 2.6 13.6 13 0 0 13 13 13 12 C2H2-type zinc finger KRAB PF01352.25 NM_153063.3_1 - 2e-20 72.0 0.0 3.5e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_153063.3_1 - 2.8e-09 36.6 73.7 0.0007 19.4 0.5 12.9 12 0 0 12 12 12 7 C2H2-type zinc finger zf-trcl PF13451.4 NM_153063.3_1 - 7.1e-07 28.9 71.7 0.17 11.7 0.2 12.4 12 2 0 12 12 12 6 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.8 NM_153063.3_1 - 8.4e-06 25.7 62.4 0.011 15.7 1.5 8.1 2 1 8 10 10 10 8 Zinc ribbon domain DUF3268 PF11672.6 NM_153063.3_1 - 7.1e-05 23.0 52.9 0.014 15.6 1.4 7.3 1 1 2 7 7 7 4 zinc-finger-containing domain XPA_N PF01286.16 NM_153063.3_1 - 7.5e-05 22.6 48.5 4.8 7.2 0.3 12.3 12 0 0 12 12 12 2 XPA protein N-terminal ADK_lid PF05191.12 NM_153063.3_1 - 0.00016 21.5 1.1 0.00016 21.5 1.1 7.7 5 1 3 8 8 8 3 Adenylate kinase, active site lid zf-C2H2_11 PF16622.3 NM_153063.3_1 - 0.015 14.9 0.9 0.015 14.9 0.9 11.6 13 0 0 13 13 13 0 zinc-finger C2H2-type C1_4 PF07975.10 NM_153063.3_1 - 0.44 10.7 69.3 0.075 13.2 5.7 9.0 3 1 5 9 9 8 0 TFIIH C1-like domain zf-C2H2_jaz PF12171.6 NM_153063.3_1 - 0.83 9.9 69.9 0.36 11.1 1.2 12.6 12 1 0 12 12 12 0 Zinc-finger double-stranded RNA-binding 7tm_4 PF13853.4 NM_146806.2_1 - 1.1e-48 166.3 21.7 1.4e-48 165.9 21.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146806.2_1 - 5.8e-19 68.2 29.4 1.3e-18 67.0 29.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Phage_holin_3_2 PF04550.10 NM_146806.2_1 - 0.34 11.2 3.2 0.52 10.6 1.6 2.0 2 0 0 2 2 2 0 Phage holin family 2 7TM_GPCR_Srsx PF10320.7 NM_146806.2_1 - 0.46 9.7 29.0 0.95 8.7 29.0 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Takusan PF04822.11 NM_001310449.1_2 - 6.9e-29 99.4 7.8 1.7e-28 98.1 7.8 1.7 1 0 0 1 1 1 1 Takusan DUF3473 PF11959.6 NM_001310449.1_2 - 0.024 14.5 0.2 0.039 13.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3473) APG6 PF04111.10 NM_001310449.1_2 - 1.9 7.7 19.4 6.4 5.9 19.4 1.7 1 1 0 1 1 1 0 Autophagy protein Apg6 bZIP_1 PF00170.19 NM_029870.2_3 - 0.0032 17.4 2.2 0.0096 15.9 1.3 2.3 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.13 NM_029870.2_3 - 0.03 14.3 1.7 0.073 13.0 1.7 1.6 1 0 0 1 1 1 0 Basic region leucine zipper CAMSAP_CKK PF08683.9 NM_001276360.1_3 - 7.6e-55 184.1 0.0 1.3e-54 183.4 0.0 1.4 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH PF11971.6 NM_001276360.1_3 - 1.1e-34 117.9 0.2 2.7e-34 116.7 0.2 1.7 1 0 0 1 1 1 1 CAMSAP CH domain CAMSAP_CC1 PF17095.3 NM_001276360.1_3 - 6.6e-26 89.8 3.7 6.6e-26 89.8 3.7 2.9 2 1 0 2 2 2 1 Spectrin-binding region of Ca2+-Calmodulin Clat_adaptor_s PF01217.18 NM_019877.2_2 - 3.2e-35 121.0 0.4 3.9e-35 120.7 0.4 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_hydro_2_C PF02836.15 NM_010368.1_1 - 2.5e-114 381.3 0.0 3.2e-114 381.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.16 NM_010368.1_1 - 6.8e-20 71.5 0.0 1.3e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.19 NM_010368.1_1 - 1.2e-08 35.4 0.1 2.1e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 ADH_zinc_N PF00107.24 NM_010368.1_1 - 0.19 11.5 0.0 2 8.2 0.0 2.2 2 0 0 2 2 2 0 Zinc-binding dehydrogenase zf-C4 PF00105.16 NM_001177303.1_1 - 4.9e-32 110.1 16.0 4.9e-32 110.1 16.0 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001177303.1_1 - 1.2e-22 80.4 0.0 1.9e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Pkr1 PF08636.8 NM_001177303.1_3 - 0.23 11.5 4.7 0.47 10.5 4.7 1.4 1 0 0 1 1 1 0 ER protein Pkr1 Asparaginase_2 PF01112.16 NM_001205054.1_2 - 8.5e-73 244.9 0.0 1.3e-72 244.3 0.0 1.2 1 0 0 1 1 1 1 Asparaginase MBT PF02820.16 NM_177278.5_1 - 5.3e-88 289.3 2.2 7.3e-29 99.8 0.1 3.4 3 0 0 3 3 3 3 mbt repeat SAM_1 PF00536.28 NM_177278.5_1 - 5.1e-14 52.3 0.0 8.6e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C2HC PF01530.16 NM_177278.5_1 - 1.5e-12 47.3 9.1 3.8e-12 46.1 9.1 1.7 1 0 0 1 1 1 1 Zinc finger, C2HC type SAM_2 PF07647.15 NM_177278.5_1 - 4e-05 23.5 0.0 6.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ste50p-SAM PF09235.8 NM_177278.5_1 - 0.15 12.2 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 Ste50p, sterile alpha motif TGS PF02824.19 NM_001163619.1_2 - 2.1e-12 46.8 0.0 3.7e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.12 NM_001163619.1_2 - 2.1e-10 40.4 0.0 5e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain UQ_con PF00179.24 NM_001168469.2_3 - 3.3e-39 133.6 0.0 4.3e-39 133.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme zf-CCCH PF00642.22 NM_001081016.1_2 - 3.9e-11 42.4 28.5 6.1e-05 22.7 3.1 4.6 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TPR_1 PF00515.26 NM_001081016.1_2 - 1.7e-07 30.6 6.2 0.00022 20.8 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001081016.1_2 - 1.1e-06 28.7 3.2 0.00023 21.2 0.6 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_001081016.1_2 - 1.2e-05 25.0 0.7 0.073 13.2 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_001081016.1_2 - 0.0005 20.1 4.0 0.0006 19.8 1.6 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.15 NM_001081016.1_2 - 0.0011 18.8 6.2 0.21 11.6 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat zf-C2H2_2 PF12756.5 NM_001081016.1_2 - 0.0043 17.2 0.2 0.011 16.0 0.2 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.6 NM_001081016.1_2 - 1.4 9.2 13.2 0.095 12.9 7.6 2.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_001081016.1_2 - 1.6 9.1 5.2 5.6 7.4 5.2 2.0 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.24 NM_001081016.1_2 - 3.6 8.1 6.4 3 8.3 1.3 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type Peptidase_M54 PF07998.9 NM_173405.2_3 - 0.0027 17.6 4.0 0.0044 16.9 4.0 1.3 1 0 0 1 1 1 1 Peptidase family M54 Cupin_8 PF13621.4 NM_001114637.1_1 - 1.8e-79 267.0 0.0 2.2e-79 266.7 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.20 NM_001114637.1_1 - 0.014 15.7 0.1 0.029 14.7 0.1 1.4 1 0 0 1 1 1 0 JmjC domain, hydroxylase ODC_AZ PF02100.15 NM_001301307.1_2 - 7.3e-20 71.0 0.0 1.2e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Anoctamin PF04547.10 NM_001291042.1_1 - 0.076 11.7 1.2 0.11 11.2 1.2 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel TMEM220 PF15071.4 NM_001291042.1_2 - 3.5e-28 98.4 3.2 3.5e-28 98.4 3.2 2.4 2 0 0 2 2 2 1 Transmembrane family 220, helix DUF4713 PF15831.3 NM_001206849.1_2 - 3.9e-19 68.7 7.7 7.1e-19 67.9 7.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4713) EVC2_like PF12297.6 NM_001206849.1_2 - 0.059 11.9 0.0 0.067 11.7 0.0 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Kunitz_BPTI PF00014.21 NM_001177401.1_3 - 1e-19 70.4 6.7 1.9e-19 69.5 6.7 1.5 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Ion_trans PF00520.29 NM_001025581.1_2 - 6.3e-44 149.9 13.5 1.7e-43 148.5 13.5 1.8 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 NM_001025581.1_2 - 4.3e-22 78.1 0.0 1.5e-15 57.1 0.0 2.4 2 0 0 2 2 2 2 BTB/POZ domain Ion_trans_2 PF07885.14 NM_001025581.1_2 - 2.4e-10 40.1 2.8 2.4e-10 40.1 2.8 2.7 2 0 0 2 2 2 1 Ion channel Methyltransf_9 PF08003.9 NM_001025581.1_3 - 0.14 10.9 0.1 0.21 10.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) GHMP_kinases_N PF00288.24 NM_023556.3_2 - 3.6e-23 81.4 0.1 1.1e-22 79.9 0.1 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.11 NM_023556.3_2 - 9.6e-05 22.5 0.1 0.00027 21.1 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.7 NM_023556.3_2 - 0.00039 19.8 0.0 0.00075 18.9 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature G_glu_transpept PF01019.19 NM_011820.4_3 - 6.1e-161 536.5 0.0 7.3e-161 536.3 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF59 PF01883.17 NM_026635.3_3 - 5e-08 32.9 0.0 8.9e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF59 Cullin_binding PF03556.13 NM_001163703.1_3 - 6.9e-31 107.0 0.3 1.3e-30 106.2 0.3 1.4 1 0 0 1 1 1 1 Cullin binding V1R PF03402.12 NM_134234.1_1 - 6.7e-27 94.6 19.6 9.2e-27 94.2 19.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 NM_134234.1_1 - 4.9e-05 22.6 16.6 7.4e-05 22.0 16.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3915 PF13054.4 NM_023814.4_1 - 0.23 11.3 1.5 0.45 10.4 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) T-box PF00907.20 NM_023814.4_3 - 3.6e-79 265.1 0.0 7.1e-79 264.2 0.0 1.5 2 0 0 2 2 2 1 T-box Amidase_2 PF01510.23 NM_207263.2_2 - 4.5e-25 88.3 0.0 7.9e-13 48.8 0.0 2.2 2 0 0 2 2 2 2 N-acetylmuramoyl-L-alanine amidase BAR PF03114.16 NM_175007.2_2 - 1.2e-55 188.7 9.1 1.8e-55 188.1 9.1 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 NM_175007.2_2 - 1.1e-07 31.5 0.1 2.7e-07 30.2 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_175007.2_2 - 4.7e-05 22.8 0.1 0.00043 19.7 0.1 2.3 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_175007.2_2 - 0.00019 20.9 0.0 0.00037 20.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain HD_3 PF13023.4 NM_175007.2_2 - 0.079 12.7 4.8 0.15 11.8 0.3 2.4 2 0 0 2 2 2 0 HD domain BAR_3 PF16746.3 NM_175007.2_2 - 0.26 10.8 9.3 0.18 11.3 6.2 2.0 1 1 1 2 2 2 0 BAR domain of APPL family EzrA PF06160.10 NM_175007.2_2 - 0.83 7.6 6.5 1.9 6.4 0.8 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Jnk-SapK_ap_N PF09744.7 NM_175007.2_2 - 1.1 9.3 11.3 0.4 10.8 2.3 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF3584 PF12128.6 NM_175007.2_2 - 1.4 6.2 9.1 4.1 4.6 9.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) IFT57 PF10498.7 NM_175007.2_2 - 3.1 6.5 8.5 0.52 9.1 2.4 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 OmpH PF03938.12 NM_175007.2_2 - 5.9 6.7 13.4 5.1 6.9 0.4 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) SH2 PF00017.22 NM_001159523.1_2 - 1.4e-14 53.7 0.0 2.1e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 SH2 domain Pkinase PF00069.23 NM_001252448.1_3 - 3.2e-35 121.6 0.0 4.1e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001252448.1_3 - 2.4e-24 85.9 0.0 1.9e-22 79.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Cystatin PF00031.19 NM_028623.5_1 - 1.2e-15 57.4 0.0 1.7e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 NM_028623.5_1 - 0.00014 22.0 0.0 0.00026 21.2 0.0 1.3 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor FAST_2 PF08368.10 NM_134011.2_1 - 7.3e-24 84.3 0.2 3.6e-23 82.0 0.0 2.4 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.13 NM_134011.2_1 - 3.1e-21 74.9 6.6 2.2e-20 72.2 0.3 3.7 3 1 0 3 3 3 1 FAST kinase-like protein, subdomain 1 RAP PF08373.8 NM_134011.2_1 - 6.4e-10 38.9 0.0 1.3e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 RAP domain TRADD_N PF09034.8 NM_134011.2_1 - 0.12 12.3 2.2 0.14 12.1 0.6 1.9 2 0 0 2 2 2 0 TRADD, N-terminal domain Rap_GAP PF02145.13 NM_001033348.3_1 - 6.5e-46 156.1 0.0 1.2e-45 155.3 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP TF_AP-2 PF03299.12 NM_011547.4_2 - 5.4e-86 287.4 0.0 7.5e-86 287.0 0.0 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 Serpin PF00079.18 NM_009776.3_2 - 1.8e-71 241.3 2.1 2.1e-71 241.0 2.1 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) TPK_catalytic PF04263.14 NM_013861.4_3 - 6.6e-39 132.5 0.0 9.1e-39 132.1 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.12 NM_013861.4_3 - 3.1e-23 81.1 0.2 5e-23 80.5 0.2 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain C2 PF00168.28 NM_030725.4_3 - 1.1e-19 70.5 0.0 3.1e-11 43.3 0.0 2.3 2 0 0 2 2 2 2 C2 domain DUF4599 PF15371.4 NM_001277167.1_3 - 4.2e-23 81.6 4.8 4.2e-23 81.6 4.8 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4599) FAM75 PF14650.4 NM_001277167.1_3 - 2.3e-19 70.1 62.1 4.5e-10 39.5 9.4 6.3 5 2 1 7 7 7 4 FAM75 family SUZ PF12752.5 NM_001277195.1_1 - 1e-12 48.5 0.2 4.1e-12 46.5 0.2 2.1 1 0 0 1 1 1 1 SUZ domain SUZ-C PF12901.5 NM_001277195.1_1 - 6.5e-09 35.5 2.1 1.8e-08 34.1 2.1 1.8 1 0 0 1 1 1 1 SUZ-C motif Acyltransferase PF01553.19 NM_145376.5_1 - 4.9e-17 61.7 0.0 7.7e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase EF-hand_8 PF13833.4 NM_145376.5_1 - 4.1e-14 52.0 2.3 9.5e-11 41.2 0.6 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.4 NM_145376.5_1 - 9.8e-11 41.9 0.2 1.3e-06 28.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 NM_145376.5_1 - 6.3e-08 31.5 1.1 0.033 13.6 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 NM_145376.5_1 - 7.6e-08 31.6 0.3 0.14 12.0 0.2 3.6 3 0 0 3 3 3 2 EF-hand domain JmjN PF02375.15 NM_145376.5_1 - 0.13 12.1 0.1 0.51 10.2 0.0 2.0 2 0 0 2 2 2 0 jmjN domain WBP-1 PF11669.6 NM_146168.1_2 - 0.00078 19.9 2.6 0.00078 19.9 2.6 2.3 2 0 0 2 2 2 1 WW domain-binding protein 1 Homeobox PF00046.27 NM_019446.4_2 - 1.5e-21 75.8 5.6 2.3e-21 75.2 5.6 1.3 1 0 0 1 1 1 1 Homeobox domain DUF498 PF04430.12 NM_183251.3_1 - 3.7e-20 71.9 0.0 5e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Indigoidine_A PF04227.10 NM_183251.3_1 - 0.011 15.0 0.0 0.014 14.6 0.0 1.1 1 0 0 1 1 1 0 Indigoidine synthase A like protein DoxX_2 PF13564.4 NM_026239.2_1 - 1.3e-05 25.1 1.8 3e-05 23.9 1.8 1.6 1 0 0 1 1 1 1 DoxX-like family DUF4131 PF13567.4 NM_026239.2_1 - 0.065 12.7 1.0 3.8 7.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) ArfGap PF01412.16 NM_001290683.1_2 - 4.9e-33 113.5 1.0 8.5e-33 112.7 0.1 1.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf GAGA_bind PF06217.10 NM_001290683.1_2 - 0.64 10.1 5.0 0.98 9.5 5.0 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family PcfK PF14058.4 NM_001290683.1_2 - 1.5 9.0 12.2 3 8.0 12.2 1.5 1 0 0 1 1 1 0 PcfK-like protein Cadherin PF00028.15 NM_001008420.2_2 - 1e-76 253.3 1.1 3.2e-18 65.8 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 NM_001008420.2_2 - 1.6e-53 180.4 1.2 2.6e-53 179.7 1.2 1.3 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.10 NM_001008420.2_2 - 5.2e-06 26.1 0.0 0.01 15.5 0.0 3.3 3 0 0 3 3 3 2 Cadherin-like TRAP_beta PF05753.12 NM_025448.3_3 - 1.8e-69 232.6 0.0 2.5e-69 232.1 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) Glyco_hydro_15 PF00723.19 NM_173021.3_2 - 1e-192 640.8 0.0 1.2e-192 640.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 7tm_4 PF13853.4 NM_146798.2_1 - 5.4e-46 157.4 20.1 7.1e-46 157.0 20.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146798.2_1 - 1.2e-19 70.4 26.8 2.2e-19 69.6 26.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Phage_holin_3_2 PF04550.10 NM_146798.2_1 - 0.65 10.3 3.7 0.26 11.6 0.6 1.9 2 0 0 2 2 2 0 Phage holin family 2 DnaB PF00772.19 NM_001319203.1_1 - 0.0017 18.3 1.0 14 5.7 0.0 5.6 3 1 3 6 6 6 2 DnaB-like helicase N terminal domain zf-H2C2_2 PF13465.4 NM_001319203.1_3 - 9.3e-149 477.7 141.1 3.2e-09 36.7 0.2 20.8 21 0 0 21 21 20 19 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001319203.1_3 - 1.1e-77 252.2 147.6 8.6e-07 29.0 0.7 20.3 20 0 0 20 20 20 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001319203.1_3 - 3.6e-57 185.9 159.9 0.00029 21.3 1.6 20.8 21 0 0 21 21 20 19 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001319203.1_3 - 6.9e-37 124.6 139.1 0.0015 18.3 1.1 20.9 21 0 0 21 21 21 18 C2H2-type zinc finger KRAB PF01352.25 NM_001319203.1_3 - 9.6e-21 73.1 0.1 1.5e-20 72.4 0.1 1.3 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 NM_001319203.1_3 - 6.3e-19 67.7 82.8 0.0038 17.4 0.1 18.6 17 1 1 18 18 18 7 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001319203.1_3 - 8.5e-08 32.1 107.5 0.12 12.4 2.2 14.3 3 1 15 18 18 18 11 Zinc ribbon domain DUF3268 PF11672.6 NM_001319203.1_3 - 4.4e-06 26.9 81.3 0.11 12.8 0.9 10.8 5 2 5 12 12 12 10 zinc-finger-containing domain C1_4 PF07975.10 NM_001319203.1_3 - 6.6e-05 23.0 91.5 0.046 13.9 6.4 12.3 3 2 13 17 17 17 6 TFIIH C1-like domain BDHCT_assoc PF16204.3 NM_001319203.1_3 - 0.0012 18.5 14.4 3.4 7.2 0.4 6.1 2 2 2 5 5 5 2 BDHCT-box associated domain on Bloom syndrome protein XPA_N PF01286.16 NM_001319203.1_3 - 0.0016 18.3 77.2 26 4.8 0.2 19.4 20 0 0 20 20 20 0 XPA protein N-terminal zf-C2H2_11 PF16622.3 NM_001319203.1_3 - 0.017 14.8 0.8 0.23 11.1 0.1 17.9 19 0 0 19 19 18 0 zinc-finger C2H2-type RyR PF02026.14 NM_001319203.1_3 - 0.02 14.9 4.0 7.2 6.7 0.0 4.4 4 0 0 4 4 4 0 RyR domain zf-LYAR PF08790.9 NM_001319203.1_3 - 0.36 10.6 85.4 2.4 8.0 0.2 17.9 19 0 0 19 19 19 0 LYAR-type C2HC zinc finger zinc_ribbon_15 PF17032.3 NM_001319203.1_3 - 6.7 7.4 95.6 0.59 10.8 2.5 10.7 1 1 11 13 13 12 0 zinc-ribbon family ATP-gua_Ptrans PF00217.17 NM_198415.2_1 - 2.7e-93 311.9 0.0 3.4e-93 311.6 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 NM_198415.2_1 - 1.2e-32 112.0 0.0 1.9e-32 111.3 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain 2-Hacid_dh_C PF02826.17 NM_016966.3_3 - 2e-58 196.5 0.0 3.5e-58 195.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 NM_016966.3_3 - 1.5e-39 134.6 0.0 2e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain WD40 PF00400.30 NM_021448.2_2 - 3.1e-34 116.3 31.5 5.6e-05 23.7 1.4 12.2 12 1 0 12 12 12 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_021448.2_2 - 1.3e-07 31.7 3.1 4.1 7.6 0.0 7.8 8 1 0 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.4 NM_021448.2_2 - 0.0011 18.2 0.0 0.025 13.6 0.0 2.2 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus eIF2A PF08662.9 NM_021448.2_2 - 0.3 10.8 4.9 6.2 6.5 0.1 3.9 5 0 0 5 5 5 0 Eukaryotic translation initiation factor eIF2A Phtf-FEM1B_bdg PF12129.6 NM_001163468.1_1 - 1.8e-31 108.9 8.5 3.3e-23 82.1 1.8 2.6 1 1 1 2 2 2 2 Male germ-cell putative homeodomain transcription factor 7tm_4 PF13853.4 NM_147081.2_1 - 3.9e-105 351.4 24.3 4.6e-105 351.2 24.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147081.2_1 - 8.9e-22 77.5 18.6 1.6e-21 76.6 18.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147081.2_1 - 1.5e-09 37.5 17.6 4.3e-09 36.0 17.6 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx GST_N PF02798.18 NM_008184.3_3 - 1.7e-20 73.0 0.0 7.3e-20 71.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 NM_008184.3_3 - 4.5e-17 61.9 0.0 7.8e-17 61.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_008184.3_3 - 1.7e-16 60.1 0.0 3.3e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 NM_008184.3_3 - 1.1e-05 25.0 0.2 3.3e-05 23.5 0.2 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 NM_008184.3_3 - 0.00042 20.1 0.2 0.0013 18.5 0.2 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 NM_008184.3_3 - 0.13 12.5 0.0 2.7 8.3 0.0 2.3 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain zf-H2C2_2 PF13465.4 NM_173364.5_3 - 9.6e-36 120.5 123.0 5.9e-07 29.5 0.1 16.8 15 2 0 15 15 15 9 Zinc-finger double domain SCAN PF02023.15 NM_173364.5_3 - 8.5e-35 118.3 2.1 2e-34 117.2 2.1 1.7 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 NM_173364.5_3 - 2.9e-34 115.5 119.7 8.7e-05 22.6 0.7 13.9 13 0 0 13 13 13 11 Zinc finger, C2H2 type KRAB PF01352.25 NM_173364.5_3 - 3.3e-21 74.6 0.2 8.3e-21 73.3 0.2 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 NM_173364.5_3 - 4.7e-19 67.3 117.8 0.014 16.0 0.9 14.5 14 0 0 14 14 14 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_173364.5_3 - 0.0046 16.7 96.3 0.18 11.7 0.2 12.7 12 1 0 12 12 12 6 C2H2-type zinc finger GAGA PF09237.9 NM_173364.5_3 - 0.062 13.0 15.6 0.91 9.2 0.7 4.0 3 0 0 3 3 3 0 GAGA factor zf-C2H2_jaz PF12171.6 NM_173364.5_3 - 0.067 13.4 63.3 0.55 10.5 0.1 10.1 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_173364.5_3 - 0.096 12.7 49.6 0.1 12.6 1.8 8.9 7 2 2 9 9 9 0 Zinc ribbon domain zinc_ribbon_15 PF17032.3 NM_173364.5_3 - 1.9 9.2 44.9 2.8 8.6 2.1 6.9 6 0 0 6 6 6 0 zinc-ribbon family WD40 PF00400.30 NM_001305675.1_3 - 8.1e-24 83.3 8.7 0.00033 21.3 0.1 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001305675.1_3 - 9.6e-06 25.7 0.1 0.73 10.0 0.0 4.4 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain LRR_8 PF13855.4 NM_011412.3_3 - 6.1e-113 368.5 96.6 1.1e-15 57.0 0.7 11.4 4 4 7 11 11 11 11 Leucine rich repeat LRR_5 PF13306.4 NM_011412.3_3 - 6.1e-43 145.7 6.8 2e-10 40.6 0.4 5.5 4 1 1 5 5 5 5 Leucine rich repeats (6 copies) EGF PF00008.25 NM_011412.3_3 - 9.7e-43 143.9 146.3 7.8e-08 32.4 5.1 12.2 13 0 0 13 13 10 9 EGF-like domain LRR_4 PF12799.5 NM_011412.3_3 - 2.7e-40 135.4 70.8 5.6e-05 23.3 1.1 13.4 9 4 4 14 14 14 14 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_011412.3_3 - 6.2e-25 87.5 33.0 6.4e-06 25.6 2.9 6.5 4 3 1 6 6 6 6 Leucine-rich repeat Laminin_G_2 PF02210.22 NM_011412.3_3 - 2.7e-23 82.8 0.0 4.3e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.5 NM_011412.3_3 - 3.9e-23 81.1 128.0 1.4e-06 28.6 5.3 13.6 13 1 0 13 13 11 9 Human growth factor-like EGF LRRNT PF01462.16 NM_011412.3_3 - 3.9e-21 74.1 67.8 5.1e-09 35.4 2.8 9.0 10 0 0 10 10 9 4 Leucine rich repeat N-terminal domain Laminin_G_1 PF00054.21 NM_011412.3_3 - 6.6e-20 71.5 0.0 1.1e-19 70.9 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain LRRCT PF01463.22 NM_011412.3_3 - 2.6e-14 52.4 22.3 0.0026 18.0 0.1 6.8 6 0 0 6 6 5 4 Leucine rich repeat C-terminal domain LRR_1 PF00560.31 NM_011412.3_3 - 3e-05 23.7 48.4 5.5 7.7 0.0 16.9 19 3 1 20 20 16 1 Leucine Rich Repeat Laminin_G_3 PF13385.4 NM_011412.3_3 - 0.0052 16.8 0.0 0.0089 16.1 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EGF_3 PF12947.5 NM_011412.3_3 - 0.0053 16.8 1.9 0.0053 16.8 1.9 12.4 13 1 0 13 13 9 6 EGF domain GST_C_2 PF13410.4 NM_027085.3_1 - 2.4e-11 43.3 0.0 4.7e-11 42.3 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 NM_027085.3_1 - 4.2e-08 33.3 0.0 8.9e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 NM_027085.3_1 - 1.3e-06 28.5 0.0 3.8e-06 27.0 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 NM_027085.3_1 - 0.044 13.9 0.0 0.077 13.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.22 NM_027085.3_1 - 0.052 13.6 0.0 0.34 11.0 0.0 2.3 3 0 0 3 3 3 0 Glutaredoxin GST_N_4 PF17172.2 NM_027085.3_1 - 0.11 13.1 0.0 0.31 11.7 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain PGM_PMM_I PF02878.14 NM_025700.2_2 - 1.2e-34 118.8 0.0 2.2e-34 118.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.14 NM_025700.2_2 - 2.1e-23 82.8 0.1 5.9e-23 81.3 0.1 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.14 NM_025700.2_2 - 4.2e-13 49.4 0.0 1.2e-12 47.9 0.0 1.8 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.18 NM_025700.2_2 - 3.8e-06 26.8 0.0 8.7e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain zf-H2C2_2 PF13465.4 NM_001289838.1_2 - 8.4e-69 225.0 145.7 3.3e-08 33.5 0.2 21.0 20 1 1 21 21 21 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001289838.1_2 - 2.6e-61 200.7 147.0 1.1e-05 25.5 1.5 18.4 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001289838.1_2 - 3.1e-24 83.4 156.5 0.011 16.4 2.4 18.8 19 0 0 19 19 19 13 C2H2-type zinc finger KRAB PF01352.25 NM_001289838.1_2 - 4.2e-06 26.2 3.7 9.2e-06 25.1 3.7 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001289838.1_2 - 0.0019 17.9 115.5 0.29 11.0 2.9 17.5 17 2 0 17 17 17 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001289838.1_2 - 0.085 12.9 96.3 0.014 15.4 3.4 12.7 6 3 8 15 15 15 0 Zinc ribbon domain BolA PF01722.16 NM_001289838.1_2 - 0.37 11.0 29.9 0.19 11.9 0.4 6.5 6 1 0 6 6 6 0 BolA-like protein BHD_1 PF10403.7 NM_001289838.1_2 - 2.1 8.1 5.1 55 3.6 0.0 5.0 4 2 0 4 4 4 0 Rad4 beta-hairpin domain 1 7tm_4 PF13853.4 NM_001011528.2_3 - 9.3e-49 166.5 18.1 1.1e-48 166.2 18.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011528.2_3 - 1.1e-21 77.2 21.1 2e-21 76.3 21.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1641 PF07849.9 NM_001011528.2_3 - 0.031 14.0 0.2 0.42 10.4 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1641) HbrB PF08539.9 NM_146061.4_3 - 9.1e-15 54.9 0.4 1.9e-13 50.6 0.1 2.2 1 1 1 2 2 2 2 HbrB-like Tetraspannin PF00335.18 NM_025982.4_1 - 3.5e-17 62.8 15.4 6.3e-17 62.0 15.4 1.4 1 0 0 1 1 1 1 Tetraspanin family YrzO PF14142.4 NM_025982.4_1 - 0.012 15.3 0.7 0.036 13.8 0.7 1.8 1 0 0 1 1 1 0 YrzO-like protein PHO4 PF01384.18 NM_025982.4_1 - 0.28 10.1 2.6 0.68 8.8 2.6 1.6 2 0 0 2 2 2 0 Phosphate transporter family Herpes_LMP1 PF05297.9 NM_025982.4_1 - 10 5.1 10.2 15 4.5 10.2 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) FCH PF00611.21 NM_019406.3_3 - 4.4e-18 65.2 2.8 4.4e-18 65.2 2.8 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Ig_2 PF13895.4 NM_001271373.1_2 - 1.1e-06 28.7 0.2 2.3e-06 27.7 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 NM_001271373.1_2 - 0.00024 21.5 0.6 0.0006 20.2 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 NM_001271373.1_2 - 0.0069 16.4 0.1 0.021 14.9 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 NM_001271373.1_2 - 0.032 14.3 0.6 3.9 7.5 0.1 2.4 1 1 1 2 2 2 0 Immunoglobulin V-set domain Orthopox_A43R PF06517.9 NM_001271373.1_2 - 0.056 13.1 0.0 6.8 6.3 0.0 2.1 2 0 0 2 2 2 0 Orthopoxvirus A43R protein I-set PF07679.14 NM_001271373.1_2 - 0.13 12.2 0.0 0.32 11.0 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin I-set domain Trypsin PF00089.24 NM_001030297.2_1 - 3.8e-69 232.7 0.1 6e-69 232.1 0.1 1.3 1 0 0 1 1 1 1 Trypsin SEA PF01390.18 NM_001030297.2_1 - 7.8e-23 80.6 1.3 1.2e-22 80.0 1.3 1.3 1 0 0 1 1 1 1 SEA domain Trypsin_2 PF13365.4 NM_001030297.2_1 - 1.7e-05 25.6 0.0 2.8e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.13 NM_001030297.2_1 - 4.9e-05 22.9 0.9 0.13 11.6 0.2 3.1 2 1 1 3 3 3 2 Chymotrypsin family Peptidase-S1 DUF1986 PF09342.9 NM_001030297.2_1 - 0.013 15.8 0.4 0.03 14.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1986) DEAD PF00270.27 NM_001142734.1_1 - 5.3e-42 143.4 0.2 8.1e-42 142.8 0.2 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001142734.1_1 - 1.6e-30 105.6 0.0 6.3e-30 103.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.4 NM_001142734.1_1 - 0.00024 21.3 0.0 0.0039 17.4 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 NM_001142734.1_1 - 0.00035 20.2 0.1 0.00056 19.6 0.1 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.13 NM_001142734.1_1 - 0.00091 19.1 0.0 0.0016 18.3 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.10 NM_001142734.1_1 - 0.014 14.0 0.0 1.9 7.1 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Fanconi_A PF03511.12 NM_001142734.1_1 - 0.053 13.3 0.2 0.31 10.8 0.1 2.2 2 0 0 2 2 2 0 Fanconi anaemia group A protein XK-related PF09815.7 NM_183319.2_1 - 2e-66 224.2 26.2 2e-66 224.2 26.2 2.1 2 0 0 2 2 2 1 XK-related protein Trypan_PARP PF05887.9 NM_183319.2_3 - 0.00038 20.4 54.7 0.0019 18.1 25.4 2.2 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) SET PF00856.26 NM_018877.3_1 - 8.4e-38 130.3 4.3 1.8e-37 129.2 0.8 2.8 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.14 NM_018877.3_1 - 1.3e-15 57.8 10.3 3.3e-15 56.5 10.3 1.8 1 0 0 1 1 1 1 Pre-SET motif MBD PF01429.17 NM_018877.3_1 - 1.2e-12 47.2 0.0 2.3e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Methyl-CpG binding domain DUF4537 PF15057.4 NM_018877.3_1 - 0.0057 16.5 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Agenet PF05641.10 NM_018877.3_1 - 0.35 11.3 1.7 13 6.2 0.0 3.3 3 0 0 3 3 3 0 Agenet domain EF-hand_7 PF13499.4 NM_001170868.1_3 - 9.2e-26 90.0 4.1 3.8e-17 62.4 0.0 3.6 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.30 NM_001170868.1_3 - 6.4e-23 78.4 4.3 3.2e-06 26.1 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.4 NM_001170868.1_3 - 9.1e-21 72.3 2.8 1.1e-06 27.7 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_001170868.1_3 - 1.1e-19 68.5 1.8 1.9e-05 24.1 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 NM_001170868.1_3 - 1.3e-16 59.9 1.1 2.6e-06 26.9 0.0 3.6 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_001170868.1_3 - 0.00023 21.3 0.1 0.056 13.6 0.0 3.0 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_001170868.1_3 - 0.0033 17.2 0.3 2 8.3 0.0 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand CPSase_L_D2 PF02786.15 NM_001162946.1_1 - 7.2e-75 251.0 0.0 1.2e-74 250.2 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.16 NM_001162946.1_1 - 2.8e-68 229.5 0.0 4.9e-68 228.7 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.20 NM_001162946.1_1 - 4.1e-43 146.3 0.0 8.7e-43 145.2 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.17 NM_001162946.1_1 - 5.3e-35 119.6 0.0 1.3e-34 118.4 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.17 NM_001162946.1_1 - 1.7e-26 93.2 0.0 3.7e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.20 NM_001162946.1_1 - 5.5e-19 67.6 2.6 5.5e-19 67.6 2.6 2.5 3 0 0 3 3 2 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.4 NM_001162946.1_1 - 3.1e-12 45.7 0.0 1.4e-11 43.5 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.11 NM_001162946.1_1 - 1.5e-09 37.6 0.0 2.7e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.4 NM_001162946.1_1 - 1.2e-05 25.0 0.1 0.0056 16.4 0.1 3.2 2 1 1 3 3 3 1 Biotin-lipoyl like ATP-grasp_3 PF02655.12 NM_001162946.1_1 - 0.0017 18.3 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain RnfC_N PF13375.4 NM_001162946.1_1 - 0.013 15.3 0.6 0.033 14.0 0.1 1.9 2 0 0 2 2 1 0 RnfC Barrel sandwich hybrid domain NQRA PF05896.9 NM_001162946.1_1 - 0.03 13.6 0.2 0.054 12.8 0.2 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) ATPgrasp_YheCD PF14398.4 NM_001162946.1_1 - 0.045 12.8 0.0 5.8 5.9 0.0 2.2 2 0 0 2 2 2 0 YheC/D like ATP-grasp HlyD_D23 PF16576.3 NM_001162946.1_1 - 0.06 12.4 0.1 2 7.4 0.0 2.3 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion PTS_EIIA_1 PF00358.18 NM_001162946.1_1 - 0.11 12.1 0.9 0.55 9.9 0.3 2.4 2 1 0 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 UCH PF00443.27 NM_001168371.2_3 - 1.8e-76 256.9 0.0 2.4e-76 256.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP19_linker PF16602.3 NM_001168371.2_3 - 4.3e-58 195.0 7.9 4.3e-58 195.0 7.9 2.4 2 0 0 2 2 2 1 Linker region of USP19 deubiquitinase UCH_1 PF13423.4 NM_001168371.2_3 - 2e-19 70.2 0.0 7.9e-09 35.4 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase CS PF04969.14 NM_001168371.2_3 - 2.1e-17 63.8 0.0 4.2e-13 50.0 0.0 2.5 2 0 0 2 2 2 2 CS domain zf-MYND PF01753.16 NM_001168371.2_3 - 2.3e-07 30.6 16.5 2.3e-07 30.6 16.5 3.1 5 0 0 5 5 5 1 MYND finger USP7_C2 PF14533.4 NM_001168371.2_3 - 0.013 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal Macro PF01661.19 NM_030253.3_2 - 7.7e-48 161.3 0.1 6.4e-30 103.5 0.0 2.4 2 0 0 2 2 2 2 Macro domain PARP PF00644.18 NM_030253.3_2 - 0.00022 20.8 0.2 0.00055 19.5 0.2 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ABC_tran_Xtn PF12848.5 NM_030253.3_2 - 0.069 13.0 0.3 0.16 11.8 0.3 1.6 1 0 0 1 1 1 0 ABC transporter Spectrin PF00435.19 NM_026319.3_3 - 0.0098 16.2 9.1 0.0098 16.2 9.1 5.9 2 2 4 6 6 6 1 Spectrin repeat Spc7 PF08317.9 NM_026319.3_3 - 0.21 10.3 92.3 0.076 11.8 10.1 4.7 1 1 3 4 4 4 0 Spc7 kinetochore protein LAGLIDADG_3 PF14528.4 NM_026319.3_3 - 4.3 7.7 5.6 1.1 9.7 0.1 2.7 2 1 0 2 2 2 0 LAGLIDADG-like domain APG6 PF04111.10 NM_026319.3_3 - 4.7 6.4 87.4 0.12 11.6 21.2 4.3 1 1 3 4 4 4 0 Autophagy protein Apg6 HLH PF00010.24 NM_011527.3_2 - 2.5e-15 56.0 0.2 4.4e-15 55.3 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.3 NM_011527.3_2 - 0.1 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain TFIIS_M PF07500.12 NM_001291433.1_3 - 5.8e-29 100.6 2.1 1.1e-28 99.8 2.1 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.11 NM_001291433.1_3 - 1.2e-25 90.1 0.0 4.9e-25 88.1 0.0 2.0 2 0 0 2 2 2 1 SPOC domain PHD PF00628.27 NM_001291433.1_3 - 7.4e-11 41.6 8.0 7.4e-11 41.6 8.0 2.9 2 0 0 2 2 2 1 PHD-finger RAG2_PHD PF13341.4 NM_001291433.1_3 - 0.11 12.5 3.3 0.94 9.4 0.3 2.8 2 0 0 2 2 2 0 RAG2 PHD domain zf-PHD-like PF15446.4 NM_001291433.1_3 - 0.16 11.5 9.7 0.09 12.3 5.7 2.2 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain MIS13 PF08202.9 NM_025853.3_1 - 1.4e-63 214.9 7.7 1.9e-63 214.4 7.7 1.2 1 0 0 1 1 1 1 Mis12-Mtw1 protein family DUF4604 PF15377.4 NM_144935.1_2 - 0.15 12.4 17.2 0.23 11.8 17.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) AP3D1 PF06375.9 NM_144935.1_2 - 2 8.6 22.1 2.9 8.0 22.1 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 PAP2 PF01569.19 NM_144935.1_3 - 2.1e-14 53.3 2.4 4e-14 52.4 2.4 1.4 1 0 0 1 1 1 1 PAP2 superfamily PDZ PF00595.22 NM_080795.4_1 - 2.3e-63 210.4 0.7 7e-15 55.0 0.0 4.3 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_080795.4_1 - 1.6e-20 73.1 0.1 2.3e-06 27.7 0.0 4.4 4 0 0 4 4 4 4 PDZ domain zf-C3HC4_2 PF13923.4 NM_080795.4_1 - 2.1e-07 30.5 9.9 2.1e-07 30.5 9.9 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_080795.4_1 - 3.9e-07 29.7 8.0 3.9e-07 29.7 8.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_080795.4_1 - 1.2e-06 28.2 9.3 1.2e-06 28.2 9.3 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.4 NM_080795.4_1 - 2.9e-06 27.0 6.5 1.1e-05 25.2 6.5 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_080795.4_1 - 3e-06 27.3 7.6 3e-06 27.3 7.6 2.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.4 NM_080795.4_1 - 1.9e-05 24.3 4.5 1.9e-05 24.3 4.5 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_080795.4_1 - 0.00021 21.2 7.5 0.00021 21.2 7.5 2.4 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.5 NM_080795.4_1 - 0.0048 17.0 6.5 0.019 15.1 6.5 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-Nse PF11789.6 NM_080795.4_1 - 0.11 12.2 2.2 0.36 10.5 2.2 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.4 NM_080795.4_1 - 1.4 8.7 11.8 0.15 11.8 6.8 2.1 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 DZR PF12773.5 NM_080795.4_1 - 1.5 8.8 9.2 2.7 7.9 5.2 2.9 2 1 0 2 2 2 0 Double zinc ribbon OLF PF02191.14 NM_019498.2_1 - 1.7e-87 293.0 6.0 2.4e-87 292.5 6.0 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.6 NM_019498.2_1 - 1.2e-47 159.8 9.6 6.3e-47 157.5 5.4 2.6 3 0 0 3 3 2 1 Neurogenesis glycoprotein EzrA PF06160.10 NM_019498.2_1 - 0.0011 17.2 5.9 0.0018 16.4 5.9 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Helo_like_N PF17111.3 NM_019498.2_1 - 0.0023 17.2 0.3 0.0023 17.2 0.3 2.3 1 1 0 2 2 2 1 Fungal N-terminal domain of STAND proteins APG17 PF04108.10 NM_019498.2_1 - 0.003 16.6 4.7 0.0049 15.9 4.7 1.2 1 0 0 1 1 1 1 Autophagy protein Apg17 zf-C4H2 PF10146.7 NM_019498.2_1 - 0.007 16.5 0.7 0.011 15.9 0.7 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein Baculo_PEP_C PF04513.10 NM_019498.2_1 - 0.013 15.4 1.0 0.096 12.6 1.0 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lipoprotein_7 PF01540.14 NM_019498.2_1 - 0.042 13.0 1.9 0.062 12.4 1.9 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein CENP-Q PF13094.4 NM_019498.2_1 - 0.055 13.5 8.1 0.1 12.6 8.1 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Reo_sigmaC PF04582.10 NM_019498.2_1 - 0.077 12.2 0.2 0.12 11.7 0.2 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein FtsZ_C PF12327.6 NM_019498.2_1 - 0.15 12.2 0.2 0.32 11.2 0.2 1.4 1 0 0 1 1 1 0 FtsZ family, C-terminal domain IncA PF04156.12 NM_019498.2_1 - 0.16 11.6 16.0 0.37 10.4 16.0 1.5 1 1 0 1 1 1 0 IncA protein DUF4795 PF16043.3 NM_019498.2_1 - 0.23 10.9 11.0 0.83 9.1 10.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Atg14 PF10186.7 NM_019498.2_1 - 0.24 10.3 9.4 0.37 9.7 9.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BLOC1_2 PF10046.7 NM_019498.2_1 - 0.39 10.9 10.3 0.41 10.9 1.9 3.2 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.10 NM_019498.2_1 - 0.42 11.0 3.9 7.2 7.0 3.3 2.8 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein AAA_13 PF13166.4 NM_019498.2_1 - 0.46 8.9 4.9 0.76 8.2 4.9 1.3 1 0 0 1 1 1 0 AAA domain Nup54 PF13874.4 NM_019498.2_1 - 0.67 9.9 7.7 1.5 8.8 7.7 1.6 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Exonuc_VII_L PF02601.13 NM_019498.2_1 - 1 8.8 6.4 1.6 8.1 6.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.10 NM_019498.2_1 - 1 9.2 9.4 6.9 6.6 4.8 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin_2 PF14523.4 NM_019498.2_1 - 1.1 9.6 9.5 18 5.6 9.5 2.3 1 1 0 1 1 1 0 Syntaxin-like protein CLZ PF16526.3 NM_019498.2_1 - 1.8 8.9 13.8 0.99 9.7 2.7 3.1 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TBCC_N PF16752.3 NM_019498.2_1 - 2.1 8.7 11.0 1.1 9.6 7.6 2.0 1 1 2 3 3 3 0 Tubulin-specific chaperone C N-terminal domain H-kinase_dim PF02895.12 NM_019498.2_1 - 3.2 8.1 6.7 63 3.9 6.7 2.5 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain Laminin_II PF06009.10 NM_019498.2_1 - 3.8 7.4 7.0 3.2 7.6 4.2 2.1 1 1 1 2 2 2 0 Laminin Domain II CorA PF01544.16 NM_019498.2_1 - 4.1 6.5 5.2 6.2 5.9 5.2 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein HSBP1 PF06825.10 NM_019498.2_1 - 4.4 7.2 6.2 53 3.7 0.4 3.5 3 0 0 3 3 3 0 Heat shock factor binding protein 1 AAA_23 PF13476.4 NM_019498.2_1 - 8.8 6.7 6.5 20 5.5 6.5 1.6 1 0 0 1 1 1 0 AAA domain V-set PF07686.15 NM_001113556.1_3 - 4.5e-14 52.4 0.5 7.1e-14 51.8 0.5 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001113556.1_3 - 0.12 12.9 0.2 0.24 11.9 0.2 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Pkinase_Tyr PF07714.15 NM_001284258.1_3 - 4.2e-81 271.9 0.0 5.7e-81 271.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001284258.1_3 - 2e-27 96.1 0.0 3e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain WIF PF02019.16 NM_001284258.1_3 - 3.5e-21 75.1 0.2 6.5e-21 74.3 0.2 1.4 1 0 0 1 1 1 1 WIF domain A2M_comp PF07678.12 NM_153098.3_1 - 8e-63 212.1 0.0 1.2e-62 211.5 0.0 1.3 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_N_2 PF07703.12 NM_153098.3_1 - 3.6e-27 95.3 1.0 4e-25 88.6 0.1 3.0 2 0 0 2 2 2 1 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 NM_153098.3_1 - 2e-26 91.5 0.1 6.6e-26 89.8 0.1 2.0 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.12 NM_153098.3_1 - 6.2e-22 78.1 0.2 1.8e-21 76.6 0.2 1.9 1 0 0 1 1 1 1 A-macroglobulin receptor Thiol-ester_cl PF10569.7 NM_153098.3_1 - 7.2e-18 63.8 0.8 1.4e-17 62.9 0.8 1.5 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region A2M_N PF01835.17 NM_153098.3_1 - 6.6e-15 55.2 0.0 4.4e-14 52.6 0.1 2.5 2 0 0 2 2 2 1 MG2 domain UCH PF00443.27 NM_001033528.1_2 - 3.9e-48 164.1 1.4 7.8e-48 163.1 1.4 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_001033528.1_2 - 5.8e-22 78.5 0.0 1e-21 77.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase EMP24_GP25L PF01105.22 NM_010744.4_2 - 5.2e-43 147.0 0.0 6.6e-43 146.6 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Calx-beta PF03160.12 NM_001112798.2_3 - 5.9e-63 209.2 8.3 8e-35 118.9 0.9 2.3 2 0 0 2 2 2 2 Calx-beta domain Na_Ca_ex PF01699.22 NM_001112798.2_3 - 3e-57 192.7 29.7 1.1e-34 119.5 10.8 4.1 4 0 0 4 4 4 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.3 NM_001112798.2_3 - 6.2e-50 168.8 5.9 1e-49 168.1 5.9 1.4 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain DnaG_DnaB_bind PF08278.9 NM_001112798.2_3 - 0.35 11.3 1.9 0.64 10.5 1.9 1.3 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding 7tm_4 PF13853.4 NM_146607.1_1 - 2.2e-53 181.6 26.7 2.6e-53 181.4 26.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146607.1_1 - 3e-23 82.3 26.4 3e-23 82.3 26.4 1.9 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF4476 PF14771.4 NM_173382.1_1 - 9e-31 105.9 1.1 5.8e-23 80.9 0.1 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) Cep57_CLD PF14073.4 NM_029132.2_3 - 7.6e-61 205.1 38.6 7.6e-61 205.1 38.6 2.3 2 0 0 2 2 2 1 Centrosome localisation domain of Cep57 Cep57_MT_bd PF06657.11 NM_029132.2_3 - 7.4e-17 61.4 6.1 7.4e-17 61.4 6.1 4.2 3 1 1 4 4 4 2 Centrosome microtubule-binding domain of Cep57 Vac_Fusion PF02346.14 NM_029132.2_3 - 3.2 7.3 9.8 0.79 9.3 0.3 3.5 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 FAM117 PF15388.4 NM_133236.3_3 - 9.2e-128 425.8 17.9 9.2e-128 425.8 17.9 2.6 2 1 0 2 2 2 1 Protein Family FAM117 Pro_isomerase PF00160.19 NM_026352.3_1 - 3e-47 160.7 0.1 4.1e-47 160.3 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.26 NM_026352.3_1 - 1.9e-16 58.9 2.0 8.6e-05 22.1 0.4 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 NM_026352.3_1 - 1.8e-13 49.3 0.2 0.0012 18.7 0.5 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.4 NM_026352.3_1 - 1.8e-07 30.6 0.0 0.0071 16.2 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 NM_026352.3_1 - 4.7e-06 26.7 0.2 1.3 9.2 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 NM_026352.3_1 - 2.1e-05 24.0 1.0 0.76 9.4 0.0 3.4 3 0 0 3 3 3 2 TPR repeat TPR_8 PF13181.4 NM_026352.3_1 - 0.002 18.1 1.7 0.48 10.6 0.2 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.4 NM_026352.3_1 - 0.005 17.4 0.2 4.3 8.3 1.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.4 NM_026352.3_1 - 0.045 13.8 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.4 NM_026352.3_1 - 0.045 14.3 0.0 0.49 11.0 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.4 NM_026352.3_1 - 0.11 12.8 2.2 0.44 10.9 2.1 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_026352.3_1 - 0.31 11.6 3.3 30 5.4 0.5 3.5 4 0 0 4 4 3 0 Tetratricopeptide repeat Adaptin_N PF01602.18 NM_001303502.1_1 - 2.1e-53 181.5 0.0 2.6e-53 181.2 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 NM_001303502.1_1 - 0.0032 17.4 0.0 0.005 16.7 0.0 1.3 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.18 NM_001303502.1_2 - 4e-83 279.6 3.3 5.1e-83 279.3 3.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.18 NM_001303502.1_2 - 1.3e-29 102.6 0.1 2.8e-29 101.5 0.1 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Kinetochor_Ybp2 PF08568.8 NM_001303502.1_2 - 0.0046 15.4 0.5 0.0071 14.7 0.5 1.2 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin Cnd1 PF12717.5 NM_001303502.1_2 - 0.045 13.6 0.7 0.38 10.6 0.4 2.4 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HCO3_cotransp PF00955.19 NM_001033270.2_2 - 6.4e-243 807.1 8.8 8.3e-243 806.7 8.8 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 NM_001033270.2_2 - 8.5e-108 360.1 0.0 1.6e-107 359.2 0.0 1.5 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Arm PF00514.21 NM_001081393.1_2 - 3.5e-51 169.6 28.9 3.7e-06 26.7 0.0 13.8 14 0 0 14 14 14 12 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 NM_001081393.1_2 - 6.7e-19 67.9 7.8 2.5e-06 27.6 0.1 7.3 3 1 4 8 8 8 5 HEAT repeats HEAT_EZ PF13513.4 NM_001081393.1_2 - 3e-12 46.6 9.7 0.001 19.3 0.3 8.8 7 3 3 10 10 10 4 HEAT-like repeat HEAT PF02985.20 NM_001081393.1_2 - 9.2e-09 34.7 15.8 0.5 10.6 0.1 9.3 10 0 0 10 10 9 3 HEAT repeat Arm_2 PF04826.11 NM_001081393.1_2 - 3.2e-08 33.2 5.7 0.081 12.2 0.1 5.7 2 2 4 6 6 6 4 Armadillo-like V-ATPase_H_C PF11698.6 NM_001081393.1_2 - 2.8e-07 30.5 8.6 2.8 7.9 0.3 6.8 3 3 4 7 7 7 3 V-ATPase subunit H KAP PF05804.10 NM_001081393.1_2 - 2.9e-07 28.9 0.3 0.12 10.3 0.0 3.2 3 0 0 3 3 3 3 Kinesin-associated protein (KAP) UNC45-central PF11701.6 NM_001081393.1_2 - 6.5e-07 29.3 2.5 0.27 11.0 0.1 4.5 3 1 1 4 4 4 2 Myosin-binding striated muscle assembly central Cnd1 PF12717.5 NM_001081393.1_2 - 4e-06 26.8 12.4 0.061 13.2 0.1 5.6 4 1 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 RasGEF_N_2 PF14663.4 NM_001081393.1_2 - 0.00073 19.7 9.1 11 6.3 0.0 6.4 6 1 1 7 7 7 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Vac14_Fab1_bd PF12755.5 NM_001081393.1_2 - 0.057 13.9 0.1 22 5.6 0.0 3.8 4 1 0 4 4 4 0 Vacuolar 14 Fab1-binding region V-ATPase_H_N PF03224.12 NM_001081393.1_2 - 1.3 8.1 5.2 5.9 5.9 0.1 3.5 3 2 2 5 5 5 0 V-ATPase subunit H ApoL PF05461.9 NM_001168660.1_2 - 1.4e-111 372.7 10.9 1.6e-111 372.5 10.9 1.0 1 0 0 1 1 1 1 Apolipoprotein L COG5 PF10392.7 NM_001168660.1_2 - 0.046 13.8 0.3 16 5.5 0.0 2.9 3 0 0 3 3 3 0 Golgi transport complex subunit 5 AAA PF00004.27 NM_016962.2_3 - 2.5e-38 131.3 0.0 4.2e-38 130.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 NM_016962.2_3 - 6e-06 26.0 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.10 NM_016962.2_3 - 4.3e-05 22.8 0.0 0.00011 21.4 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus MIT PF04212.16 NM_016962.2_3 - 0.00015 21.6 0.6 0.00029 20.7 0.6 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_5 PF07728.12 NM_016962.2_3 - 0.001 18.9 0.1 0.0053 16.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.11 NM_016962.2_3 - 0.0024 16.7 0.0 0.0042 16.0 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus TniB PF05621.9 NM_016962.2_3 - 0.003 16.7 0.1 3.2 6.7 0.0 2.8 1 1 1 2 2 2 2 Bacterial TniB protein AAA_22 PF13401.4 NM_016962.2_3 - 0.0051 16.9 0.2 0.11 12.6 0.0 2.6 2 1 1 3 3 3 1 AAA domain AAA_2 PF07724.12 NM_016962.2_3 - 0.0088 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.19 NM_016962.2_3 - 0.011 15.0 0.3 0.027 13.7 0.3 1.6 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.4 NM_016962.2_3 - 0.02 14.8 0.0 0.21 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.15 NM_016962.2_3 - 0.041 13.5 0.0 0.069 12.8 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.11 NM_016962.2_3 - 0.048 12.7 0.0 0.081 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.4 NM_016962.2_3 - 0.082 12.5 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 NM_016962.2_3 - 0.094 13.0 0.2 0.37 11.0 0.2 2.0 1 1 0 1 1 1 0 AAA ATPase domain LRR_8 PF13855.4 NM_001013758.2_2 - 9.7e-68 223.7 51.5 2.3e-16 59.1 1.1 6.6 1 1 7 8 8 8 8 Leucine rich repeat LRR_4 PF12799.5 NM_001013758.2_2 - 2.1e-19 69.1 23.0 4.3e-05 23.6 1.3 6.8 4 1 1 6 6 6 4 Leucine Rich repeats (2 copies) I-set PF07679.14 NM_001013758.2_2 - 1e-16 60.6 0.0 1.5e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001013758.2_2 - 1.6e-15 57.3 0.1 4.2e-15 56.0 0.0 1.8 2 0 0 2 2 1 1 Immunoglobulin domain ig PF00047.23 NM_001013758.2_2 - 4.2e-10 39.5 0.0 1e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 NM_001013758.2_2 - 5.1e-08 33.0 0.0 1.3e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 NM_001013758.2_2 - 6.5e-05 22.7 25.9 16 6.3 0.0 10.5 10 1 0 10 10 10 0 Leucine Rich Repeat LRR_9 PF14580.4 NM_001013758.2_2 - 8.6e-05 22.0 7.1 0.26 10.6 0.2 3.5 1 1 3 4 4 4 3 Leucine-rich repeat LRRNT PF01462.16 NM_001013758.2_2 - 0.00029 20.3 1.6 0.00029 20.3 1.6 3.9 4 0 0 4 4 4 1 Leucine rich repeat N-terminal domain V-set PF07686.15 NM_001013758.2_2 - 0.00073 19.5 0.1 0.0046 17.0 0.1 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRR_6 PF13516.4 NM_001013758.2_2 - 0.062 13.2 26.8 0.65 10.1 0.1 8.5 10 0 0 10 10 9 0 Leucine Rich repeat TAS2R PF05296.11 NM_001166745.1_1 - 7.2e-14 51.5 19.4 8.4e-14 51.2 19.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 NM_001166745.1_1 - 2.5e-13 50.1 13.1 3.5e-13 49.7 13.1 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 NM_001166745.1_1 - 8.3e-07 28.4 16.8 1e-06 28.1 16.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PRP8_domainIV PF12134.6 NM_001166745.1_1 - 0.0061 16.1 0.8 0.1 12.1 0.1 2.6 2 1 1 3 3 3 1 PRP8 domain IV core DUF1700 PF08006.9 NM_001166745.1_1 - 0.24 10.8 8.6 0.17 11.3 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Anoctamin PF04547.10 NM_001166745.1_1 - 0.79 8.3 9.4 0.38 9.4 7.3 1.5 1 1 0 1 1 1 0 Calcium-activated chloride channel OB_NTP_bind PF07717.14 NM_007839.3_2 - 5.2e-27 94.1 0.1 1.1e-26 93.0 0.1 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 NM_007839.3_2 - 3.3e-24 85.1 0.2 3.3e-24 85.1 0.2 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.29 NM_007839.3_2 - 1.9e-12 47.4 0.0 4.1e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 NM_007839.3_2 - 1.5e-06 28.0 0.0 3.3e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.4 NM_007839.3_2 - 0.00011 22.5 0.0 0.00023 21.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 NM_007839.3_2 - 0.00066 19.8 0.1 0.0038 17.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.20 NM_007839.3_2 - 0.0035 16.9 0.0 0.0082 15.7 0.0 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain ResIII PF04851.13 NM_007839.3_2 - 0.0044 16.9 0.0 0.62 9.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.4 NM_007839.3_2 - 0.0072 15.9 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.4 NM_007839.3_2 - 0.023 14.2 0.0 0.05 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.12 NM_007839.3_2 - 0.024 14.5 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_29 PF13555.4 NM_007839.3_2 - 0.027 14.1 0.0 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Atrophin-1 PF03154.13 NM_007839.3_2 - 0.089 10.9 9.6 0.13 10.4 9.6 1.2 1 0 0 1 1 1 0 Atrophin-1 family DUF1777 PF08648.10 NM_007839.3_2 - 0.16 12.1 19.3 0.26 11.4 19.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) AAA_23 PF13476.4 NM_007839.3_2 - 0.23 11.8 1.2 0.53 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain GKAP PF03359.11 NM_144553.2_1 - 7.2e-32 111.2 1.3 7.2e-32 111.2 1.3 3.3 4 0 0 4 4 4 1 Guanylate-kinase-associated protein (GKAP) protein Jun PF03957.11 NM_010592.5_2 - 2.2e-77 259.9 14.3 3.6e-77 259.2 14.3 1.3 1 0 0 1 1 1 1 Jun-like transcription factor bZIP_1 PF00170.19 NM_010592.5_2 - 1.4e-16 60.2 17.1 3.1e-16 59.1 17.1 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.15 NM_010592.5_2 - 1.6e-08 34.8 8.6 3.5e-08 33.7 8.6 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.13 NM_010592.5_2 - 2.7e-07 30.4 13.2 2.7e-07 30.4 13.2 1.8 2 0 0 2 2 1 1 Basic region leucine zipper PspA_IM30 PF04012.10 NM_010592.5_2 - 0.021 14.3 2.5 0.036 13.5 2.5 1.3 1 0 0 1 1 1 0 PspA/IM30 family DUF737 PF05300.9 NM_010592.5_2 - 0.058 13.6 3.9 0.15 12.3 3.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF737) TSC22 PF01166.16 NM_010592.5_2 - 0.13 12.4 0.5 0.26 11.5 0.5 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family Jnk-SapK_ap_N PF09744.7 NM_010592.5_2 - 0.34 11.0 6.4 0.6 10.2 6.4 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF3450 PF11932.6 NM_010592.5_2 - 0.64 9.1 3.1 0.94 8.6 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) ZapB PF06005.10 NM_010592.5_2 - 0.75 10.2 9.0 0.062 13.6 4.1 1.7 2 0 0 2 2 2 0 Cell division protein ZapB Mnd1 PF03962.13 NM_010592.5_2 - 3 7.5 5.7 4.7 6.9 5.7 1.2 1 0 0 1 1 1 0 Mnd1 family Ofd1_CTDD PF10637.7 NM_001093757.1_2 - 8e-41 139.9 0.1 8.2e-38 130.1 0.0 2.5 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.4 NM_001093757.1_2 - 1.7e-25 89.3 0.1 1.8e-21 76.5 0.0 2.4 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.4 NM_001093757.1_2 - 8.1e-10 39.3 0.0 4.2e-08 33.8 0.0 2.3 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily LIM PF00412.20 NM_026148.3_2 - 1.1e-60 201.6 59.4 8.5e-14 51.4 3.0 5.8 5 0 0 5 5 5 5 LIM domain Fascin PF06268.11 NM_172802.4_2 - 4.6e-114 374.4 0.0 7.5e-32 109.7 0.1 4.1 4 0 0 4 4 4 4 Fascin domain FRG1 PF06229.10 NM_172802.4_2 - 1.5e-13 50.8 0.0 4.1e-05 23.2 0.0 6.5 2 1 6 8 8 8 5 FRG1-like domain FGF PF00167.16 NM_172802.4_2 - 3e-07 30.4 0.0 0.00068 19.6 0.0 2.7 2 0 0 2 2 2 2 Fibroblast growth factor DUF569 PF04601.11 NM_172802.4_2 - 0.021 14.4 0.0 0.8 9.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF569) Sulfotransfer_1 PF00685.25 NM_001101534.1_1 - 1.5e-80 270.4 0.1 1.9e-80 270.1 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_001101534.1_1 - 1e-08 35.7 0.0 1.5e-07 31.9 0.0 2.2 1 1 0 2 2 2 1 Sulfotransferase family ESR1_C PF12743.5 NM_178614.4_1 - 2.2 7.9 4.5 16 5.2 0.4 2.5 2 0 0 2 2 2 0 Oestrogen-type nuclear receptor final C-terminal Bac_surface_Ag PF01103.21 NM_178614.4_3 - 1.1e-64 218.9 0.7 1.3e-64 218.6 0.7 1.1 1 0 0 1 1 1 1 Surface antigen V-set PF07686.15 NM_011927.4_3 - 5.7e-20 71.4 1.2 4.5e-12 46.0 0.1 3.2 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_011927.4_3 - 1.1e-18 67.4 0.1 5.4e-12 46.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 NM_011927.4_3 - 4.1e-16 58.7 0.0 2.3e-10 40.2 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 NM_011927.4_3 - 7.9e-15 54.7 0.8 1.1e-10 41.3 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 NM_011927.4_3 - 6.4e-10 39.1 0.1 8.8e-08 32.3 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Receptor_2B4 PF11465.6 NM_011927.4_3 - 2.8e-05 24.1 0.0 0.046 13.8 0.0 2.3 2 0 0 2 2 2 2 Natural killer cell receptor 2B4 Izumo-Ig PF16706.3 NM_011927.4_3 - 0.029 14.3 0.1 0.27 11.2 0.0 2.3 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 NM_011927.4_3 - 0.093 13.0 0.0 0.42 10.9 0.0 2.2 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Cadherin PF00028.15 NM_001271800.1_1 - 2.5e-99 325.8 11.9 7.9e-20 71.0 0.2 7.3 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.9 NM_001271800.1_1 - 4.7e-82 275.1 0.5 7.5e-82 274.4 0.5 1.3 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.10 NM_001271800.1_1 - 1.2e-17 63.4 0.1 2.7e-08 33.4 0.0 5.8 6 0 0 6 6 6 3 Cadherin-like Cadherin_3 PF16184.3 NM_001271800.1_1 - 6.4e-07 29.2 17.2 0.82 9.6 0.0 5.9 6 0 0 6 6 6 4 Cadherin-like EphA2_TM PF14575.4 NM_001271800.1_1 - 0.01 16.5 0.3 0.026 15.2 0.3 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain He_PIG PF05345.10 NM_001271800.1_1 - 0.014 15.4 8.5 1.5 8.9 0.0 5.0 5 0 0 5 5 5 0 Putative Ig domain DUF1510 PF07423.9 NM_001271800.1_1 - 0.029 13.7 0.2 0.054 12.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) AP3D1 PF06375.9 NM_001271800.1_1 - 0.067 13.3 0.8 0.15 12.2 0.8 1.5 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 PI3Ka PF00613.18 NM_029094.3_1 - 2.9e-64 215.8 0.5 8.5e-64 214.2 0.2 1.8 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.25 NM_029094.3_1 - 5.8e-62 209.6 0.0 1.2e-61 208.6 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_p85B PF02192.14 NM_029094.3_1 - 1.1e-31 108.2 0.2 3e-31 106.8 0.2 1.8 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain PI3K_rbd PF00794.16 NM_029094.3_1 - 1.3e-30 105.6 0.1 2.8e-30 104.5 0.1 1.6 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.22 NM_029094.3_1 - 7.8e-20 71.2 0.0 1.7e-19 70.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 RWD PF05773.20 NM_029094.3_1 - 0.037 14.2 0.2 4.4 7.5 0.1 2.7 2 0 0 2 2 2 0 RWD domain DUF4135 PF13575.4 NM_029094.3_1 - 0.12 11.6 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Tom37_C PF11801.6 NM_029094.3_1 - 0.13 12.0 0.0 0.37 10.6 0.0 1.7 1 0 0 1 1 1 0 Tom37 C-terminal domain TAS2R PF05296.11 NM_001166844.1_1 - 1.3e-14 53.9 15.4 1.6e-14 53.6 15.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 NM_001166844.1_1 - 1.8e-14 53.9 11.9 2.4e-14 53.5 11.9 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 NM_001166844.1_1 - 2.9e-06 26.6 14.9 3.8e-06 26.2 14.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1700 PF08006.9 NM_001166844.1_1 - 0.093 12.1 5.5 0.14 11.6 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) PTEN_C2 PF10409.7 NM_008960.2_2 - 5.3e-46 155.6 2.5 8e-46 155.0 2.5 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.18 NM_008960.2_2 - 9.6e-07 28.5 0.0 2.1e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 NM_008960.2_2 - 0.0021 17.5 0.0 0.0036 16.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 NM_008960.2_2 - 0.025 14.4 0.0 0.04 13.7 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.4 NM_008960.2_2 - 0.059 13.4 0.0 0.096 12.7 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate 7tm_4 PF13853.4 NM_001011756.1_1 - 4.2e-49 167.6 26.1 5.5e-49 167.3 26.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011756.1_1 - 2e-21 76.3 27.1 4.1e-21 75.3 27.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Glycoprotein_G PF00802.17 NM_001011756.1_1 - 0.063 12.5 0.7 0.097 11.9 0.7 1.2 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G 7TM_GPCR_Srv PF10323.7 NM_001011756.1_1 - 0.076 12.2 25.7 0.024 13.8 17.6 2.4 1 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv Laminin_EGF PF00053.22 NM_001032413.1_1 - 9.5e-33 112.0 266.7 0.00021 21.2 14.4 16.2 5 4 10 15 15 15 11 Laminin EGF domain EGF_2 PF07974.11 NM_001032413.1_1 - 9.9e-07 28.9 310.6 0.003 17.8 15.2 22.6 18 9 0 18 18 18 10 EGF-like domain hEGF PF12661.5 NM_001032413.1_1 - 0.0001 22.7 52.1 0.0014 19.1 2.0 22.0 21 4 3 24 24 24 11 Human growth factor-like EGF EGF PF00008.25 NM_001032413.1_1 - 0.0048 17.0 14.9 0.0048 17.0 14.9 20.2 19 1 0 19 19 19 7 EGF-like domain Mito_carr PF00153.25 NM_001007570.2_3 - 4.9e-69 228.2 0.5 7.6e-24 83.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3915 PF13054.4 NM_001159297.1_2 - 0.89 9.4 3.3 2 8.3 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) HGAL PF15666.3 NM_001159297.1_3 - 9e-37 124.9 0.8 1.9e-36 123.9 0.8 1.6 1 0 0 1 1 1 1 Germinal center-associated lymphoma DUF3915 PF13054.4 NM_001159297.1_3 - 1.5 8.7 6.7 2.6 7.9 6.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) SHIPPO-rpt PF07004.10 NM_030189.3_1 - 3.5e-12 46.5 19.8 0.052 14.4 1.6 7.2 6 0 0 6 6 6 5 Sperm-tail PG-rich repeat Piwi PF02171.15 NM_153403.3_1 - 1e-108 363.0 0.0 1.4e-108 362.5 0.0 1.1 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 NM_153403.3_1 - 4.5e-34 116.4 0.1 9.5e-34 115.4 0.1 1.6 1 0 0 1 1 1 1 Mid domain of argonaute PAZ PF02170.20 NM_153403.3_1 - 2.7e-29 101.6 1.4 4.3e-29 101.0 1.4 1.3 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.3 NM_153403.3_1 - 1.5e-26 93.5 0.0 2.6e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 NM_153403.3_1 - 4.1e-23 80.6 0.0 7.6e-23 79.8 0.0 1.5 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.3 NM_153403.3_1 - 1.5e-15 57.1 0.1 2.9e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 Argonaute linker 2 domain SASRP1 PF15160.4 NM_027649.3_2 - 1.2e-136 453.7 2.4 1.5e-136 453.4 2.4 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated serine-rich protein 1 FlaC_arch PF05377.9 NM_001290721.1_1 - 0.00071 19.8 1.5 0.00071 19.8 1.5 12.0 5 3 6 13 13 13 2 Flagella accessory protein C (FlaC) Pox_A3L PF05288.9 NM_001290721.1_1 - 0.0011 18.8 6.9 0.03 14.2 0.2 4.5 3 0 0 3 3 3 1 Poxvirus A3L Protein ERM PF00769.17 NM_001290721.1_1 - 0.0024 17.6 28.3 0.0024 17.6 28.3 7.5 1 1 7 8 8 8 3 Ezrin/radixin/moesin family DUF1664 PF07889.10 NM_001290721.1_1 - 0.0096 15.8 6.5 0.0096 15.8 6.5 9.5 3 2 7 10 10 10 4 Protein of unknown function (DUF1664) DUF972 PF06156.11 NM_001290721.1_1 - 0.015 15.8 6.5 0.015 15.8 6.5 10.7 3 3 5 11 11 11 0 Protein of unknown function (DUF972) APG6 PF04111.10 NM_001290721.1_1 - 0.093 12.0 127.8 0.032 13.5 18.0 6.3 2 1 4 6 6 6 0 Autophagy protein Apg6 Reo_sigmaC PF04582.10 NM_001290721.1_1 - 2.6 7.2 46.2 0.076 12.3 6.2 6.5 2 1 4 7 7 7 0 Reovirus sigma C capsid protein Fez1 PF06818.13 NM_001290721.1_1 - 2.9 8.2 120.9 0.6 10.4 22.6 7.0 1 1 4 5 5 5 0 Fez1 DUF211 PF02680.12 NM_001290721.1_1 - 8 6.6 8.0 20 5.3 0.0 4.0 4 1 0 4 4 4 0 Uncharacterized ArCR, COG1888 LIM PF00412.20 NM_021459.4_3 - 1.6e-26 92.2 19.1 1.6e-13 50.5 1.9 2.5 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 NM_021459.4_3 - 2.2e-14 52.8 0.2 2.2e-14 52.8 0.2 1.9 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 NM_021459.4_3 - 0.0001 22.0 0.0 0.00027 20.6 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain Ig_3 PF13927.4 NM_178899.5_3 - 1.5e-22 79.8 1.7 2.5e-13 50.3 0.3 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_178899.5_3 - 3e-18 65.6 0.1 1.7e-10 40.7 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 NM_178899.5_3 - 1.2e-14 54.1 0.2 7e-08 32.4 0.1 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_178899.5_3 - 2e-13 50.3 1.3 8.1e-09 35.6 0.1 2.8 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 NM_178899.5_3 - 5.5e-11 42.4 0.1 0.00017 21.5 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin V-set domain C2-set PF05790.13 NM_178899.5_3 - 0.13 12.3 0.0 0.65 10.1 0.0 2.2 2 1 0 2 2 2 0 Immunoglobulin C2-set domain PgaD PF13994.4 NM_178899.5_3 - 0.28 11.0 0.0 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 PgaD-like protein Forkhead PF00250.16 NM_001033469.2_1 - 0.00011 22.3 0.0 0.0002 21.5 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain bZIP_Maf PF03131.15 NM_001304832.1_1 - 3e-32 110.9 10.2 4.4e-32 110.3 10.2 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.19 NM_001304832.1_1 - 0.003 17.5 14.3 0.0092 15.9 14.3 1.7 1 1 0 1 1 1 1 bZIP transcription factor DivIC PF04977.13 NM_001304832.1_1 - 0.091 12.4 4.8 0.046 13.4 2.0 1.8 1 1 1 2 2 2 0 Septum formation initiator bZIP_2 PF07716.13 NM_001304832.1_1 - 0.092 12.7 12.3 0.2 11.6 12.3 1.6 1 0 0 1 1 1 0 Basic region leucine zipper DUF1192 PF06698.9 NM_001304832.1_1 - 5.1 7.1 7.2 0.49 10.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DSPc PF00782.18 NM_019637.3_3 - 5.8e-37 126.3 0.0 8.2e-37 125.9 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain 7tm_4 PF13853.4 NM_011001.2_1 - 8.6e-51 173.2 23.1 1.1e-50 172.9 23.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_011001.2_1 - 6e-22 78.0 23.8 2.1e-21 76.2 23.8 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_011001.2_1 - 5.3e-07 29.1 21.9 8.8e-07 28.4 21.9 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SLC3A2_N PF16028.3 NM_011001.2_1 - 0.021 14.2 0.1 0.063 12.7 0.1 1.8 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus Alpha-amylase_C PF02806.16 NM_001110505.1_3 - 3.3e-16 59.4 0.2 7.8e-16 58.2 0.2 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.22 NM_001110505.1_3 - 1.8e-14 54.0 0.0 2.7e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain LSR PF05624.12 NM_001110505.1_3 - 0.047 13.5 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) Sulfotransfer_1 PF00685.25 NM_016803.3_2 - 6.7e-54 183.0 0.0 9e-54 182.6 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 NM_016803.3_2 - 2.5e-08 34.4 0.0 5.2e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Sulfotransferase family DUF443 PF04276.10 NM_016803.3_2 - 1.3 8.6 3.4 2 8.0 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF443) TMEM144 PF07857.10 NM_027495.4_3 - 1.9e-137 457.6 12.1 2.3e-137 457.3 12.1 1.1 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.10 NM_027495.4_3 - 3.3e-09 36.4 4.0 3.3e-09 36.4 4.0 2.3 2 0 0 2 2 2 2 Sugar transport protein EPO_TPO PF00758.16 NM_007942.2_3 - 3.8e-66 221.9 0.0 4.9e-66 221.5 0.0 1.1 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin Ig_2 PF13895.4 NM_001029984.2_1 - 2.6e-23 82.0 0.1 8.5e-11 41.9 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 NM_001029984.2_1 - 1.2e-09 38.5 1.2 0.006 17.0 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 NM_001029984.2_1 - 0.0055 16.7 0.7 3 8.0 0.1 4.4 3 2 0 3 3 3 1 Immunoglobulin domain 3Beta_HSD PF01073.17 NM_001040684.1_1 - 1.1e-95 319.7 0.0 1.5e-95 319.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 NM_001040684.1_1 - 9.1e-22 77.5 0.0 1.4e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 NM_001040684.1_1 - 1.8e-14 53.4 0.1 1.3e-12 47.3 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 NM_001040684.1_1 - 2.4e-13 50.0 0.0 4.3e-13 49.2 0.0 1.4 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 NM_001040684.1_1 - 5.7e-11 42.5 0.0 8.3e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.13 NM_001040684.1_1 - 6.2e-10 38.6 0.1 1.1e-09 37.8 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.15 NM_001040684.1_1 - 6.8e-07 28.5 0.0 1.1e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 NM_001040684.1_1 - 2.4e-06 27.4 0.0 4.5e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 KR domain NmrA PF05368.11 NM_001040684.1_1 - 5.6e-06 25.9 0.0 8e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.23 NM_001040684.1_1 - 0.0019 17.5 0.1 0.0034 16.7 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.16 NM_001040684.1_1 - 0.004 17.3 0.1 0.053 13.6 0.1 2.1 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain His_Phos_2 PF00328.20 NM_019800.4_2 - 8.3e-26 91.1 0.0 2.7e-17 63.0 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) BTB PF00651.29 NM_025788.3_2 - 5.8e-24 84.3 0.1 9.1e-24 83.7 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain BEN PF10523.7 NM_025788.3_2 - 9.6e-09 35.2 0.1 2.2e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 BEN domain Cystatin PF00031.19 NM_001001332.2_1 - 1e-22 80.1 0.2 1.4e-22 79.6 0.2 1.2 1 0 0 1 1 1 1 Cystatin domain RPEL PF02755.13 NM_028806.2_3 - 1.5e-19 68.9 21.1 3.4e-06 26.4 3.2 4.5 4 0 0 4 4 4 4 RPEL repeat Sod_Ni PF09055.9 NM_028806.2_3 - 0.065 13.7 1.0 0.12 12.7 1.0 1.3 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase Tropomodulin PF03250.12 NM_001038710.1_2 - 8.9e-58 194.2 5.2 1.3e-57 193.7 5.2 1.2 1 0 0 1 1 1 1 Tropomodulin LRR_6 PF13516.4 NM_001038710.1_2 - 1.1 9.4 3.0 0.62 10.1 0.1 2.3 2 0 0 2 2 2 0 Leucine Rich repeat Fox-1_C PF12414.6 NM_021477.5_1 - 4.2e-41 139.0 21.1 8.9e-41 138.0 21.1 1.6 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 NM_021477.5_1 - 1.3e-17 63.2 0.1 2.3e-17 62.5 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Auts2 PF15336.4 NM_028596.2_2 - 1.6e-73 247.3 9.6 1.6e-73 247.3 9.6 4.0 3 1 0 3 3 3 2 Autism susceptibility gene 2 protein LRR_8 PF13855.4 NM_001289475.1_3 - 5.4e-36 122.0 32.7 1.2e-08 34.4 1.9 7.2 4 2 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 NM_001289475.1_3 - 1.7e-24 85.2 45.2 0.00034 20.8 0.0 10.6 6 2 6 13 13 13 10 Leucine Rich repeats (2 copies) PDZ PF00595.22 NM_001289475.1_3 - 1.5e-13 50.7 0.0 3.1e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LRR_5 PF13306.4 NM_001289475.1_3 - 0.00012 21.9 4.8 0.015 15.1 0.3 3.8 3 1 1 4 4 4 1 Leucine rich repeats (6 copies) PDZ_2 PF13180.4 NM_001289475.1_3 - 0.00053 20.1 0.0 0.0014 18.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain LRR_1 PF00560.31 NM_001289475.1_3 - 0.43 11.1 23.7 10 6.9 0.1 10.0 9 3 0 9 9 9 0 Leucine Rich Repeat LRR_6 PF13516.4 NM_001289475.1_3 - 1.2 9.3 19.3 13 6.0 0.1 7.0 7 0 0 7 7 7 0 Leucine Rich repeat CART PF06373.9 NM_001081493.2_2 - 9.5e-39 131.3 4.0 1.8e-38 130.4 4.0 1.5 1 0 0 1 1 1 1 Cocaine and amphetamine regulated transcript protein (CART) Spore_Cse60 PF10957.6 NM_001081493.2_2 - 0.025 14.5 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Sporulation protein Cse60 DUF2114 PF09887.7 NM_001081493.2_2 - 0.13 10.6 0.0 0.17 10.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2114) Ion_trans PF00520.29 NM_018732.3_2 - 3.8e-256 844.9 110.4 3e-82 275.4 14.6 4.8 5 0 0 5 5 5 4 Ion transport protein Na_trans_assoc PF06512.11 NM_018732.3_2 - 2.2e-55 187.7 1.7 2.2e-55 187.7 1.7 2.8 3 1 0 3 3 3 1 Sodium ion transport-associated Na_trans_cytopl PF11933.6 NM_018732.3_2 - 6.9e-45 153.4 13.8 4.1e-38 131.3 7.4 2.7 1 1 1 2 2 2 2 Cytoplasmic domain of voltage-gated Na+ ion channel GPHH PF16905.3 NM_018732.3_2 - 6e-05 22.6 0.0 0.00013 21.6 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.10 NM_018732.3_2 - 0.00012 20.8 87.6 0.00019 20.1 0.2 10.1 7 4 4 11 11 11 5 Polycystin cation channel ATP-synt_B PF00430.16 NM_018732.3_2 - 0.0014 18.6 5.2 0.0051 16.8 5.2 2.0 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) Tmemb_9 PF05434.9 NM_018732.3_2 - 0.14 11.9 1.8 19 4.9 0.1 3.0 2 0 0 2 2 2 0 TMEM9 IQ PF00612.25 NM_018732.3_2 - 0.15 11.8 0.4 0.4 10.5 0.4 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif SieB PF14163.4 NM_018732.3_2 - 2.2 7.6 8.3 0.45 9.9 0.5 3.2 3 0 0 3 3 3 0 Super-infection exclusion protein B AAA_33 PF13671.4 NM_201369.3_2 - 1.8e-14 54.0 0.0 2.6e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 NM_201369.3_2 - 0.00019 20.6 0.0 0.0003 20.0 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.4 NM_201369.3_2 - 0.00093 19.6 0.0 0.0018 18.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 NM_201369.3_2 - 0.031 13.6 0.0 0.052 12.8 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 IncA PF04156.12 NM_201369.3_2 - 0.032 13.9 1.7 0.053 13.2 1.7 1.2 1 0 0 1 1 1 0 IncA protein AAA_16 PF13191.4 NM_201369.3_2 - 0.04 14.1 0.0 0.07 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Mis12 PF05859.10 NM_025993.2_1 - 1.7e-26 92.7 1.7 2.6e-26 92.1 1.7 1.3 1 0 0 1 1 1 1 Mis12 protein G0-G1_switch_2 PF15103.4 NM_008059.3_1 - 1.9e-41 140.6 0.4 1.9e-41 140.6 0.4 1.7 2 0 0 2 2 2 1 G0/G1 switch protein 2 Ceramidase PF05875.10 NM_139306.3_1 - 1e-53 182.4 13.4 1.4e-53 181.9 13.4 1.1 1 0 0 1 1 1 1 Ceramidase CLTH PF10607.7 NM_021500.2_3 - 1.4e-30 106.0 0.1 2.2e-30 105.3 0.1 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Mic1 PF07035.10 NM_021500.2_3 - 0.00086 19.0 0.3 0.0023 17.6 0.1 1.8 2 0 0 2 2 2 1 Colon cancer-associated protein Mic1-like LisH PF08513.9 NM_021500.2_3 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 LisH zf-H2C2_2 PF13465.4 NM_001285797.1_3 - 7.7e-133 427.4 136.5 7.1e-09 35.6 1.1 24.2 25 0 0 25 25 24 21 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001285797.1_3 - 4.5e-111 357.4 152.0 7.6e-07 29.1 0.5 24.4 24 0 0 24 24 24 21 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001285797.1_3 - 4.7e-52 170.0 146.0 0.0091 16.6 0.3 23.9 24 0 0 24 24 23 20 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001285797.1_3 - 8.8e-21 73.6 82.8 0.0037 17.2 0.7 14.1 8 4 5 14 14 14 12 Zinc ribbon domain KRAB PF01352.25 NM_001285797.1_3 - 5.7e-20 70.6 0.3 1e-19 69.8 0.3 1.5 1 0 0 1 1 1 1 KRAB box DZR PF12773.5 NM_001285797.1_3 - 7.1e-06 25.8 93.8 2 8.4 4.0 12.2 4 2 2 6 6 2 1 Double zinc ribbon zinc_ribbon_15 PF17032.3 NM_001285797.1_3 - 1.9e-05 25.2 75.0 0.18 12.5 1.2 11.4 2 2 11 14 14 14 8 zinc-ribbon family C1_4 PF07975.10 NM_001285797.1_3 - 0.00011 22.2 88.5 0.24 11.5 1.6 13.4 7 4 7 14 14 13 5 TFIIH C1-like domain zf-C2H2_jaz PF12171.6 NM_001285797.1_3 - 0.0008 19.5 82.6 1.1 9.6 0.2 16.4 19 0 0 19 19 17 5 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_001285797.1_3 - 0.00095 19.4 73.0 0.49 10.6 1.1 11.8 4 3 4 13 13 13 9 zinc-finger-containing domain ADK_lid PF05191.12 NM_001285797.1_3 - 0.011 15.6 0.3 0.011 15.6 0.3 12.0 8 4 7 15 15 15 0 Adenylate kinase, active site lid zf-C2H2_11 PF16622.3 NM_001285797.1_3 - 0.04 13.6 0.2 0.24 11.0 0.1 19.8 22 0 0 22 22 21 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 NM_001285797.1_3 - 0.11 12.4 112.6 0.16 11.8 0.7 19.7 21 0 0 21 21 21 0 C2H2-type zinc finger XPA_N PF01286.16 NM_001285797.1_3 - 0.95 9.4 67.6 13 5.8 0.0 18.9 21 0 0 21 21 21 0 XPA protein N-terminal Zn_ribbon_recom PF13408.4 NM_001285797.1_3 - 2 8.9 97.1 2.3 8.7 1.2 14.2 6 5 9 15 15 14 0 Recombinase zinc beta ribbon domain Zwint PF15556.4 NM_001293683.1_2 - 9e-81 270.9 31.5 1.2e-80 270.5 31.5 1.1 1 0 0 1 1 1 1 ZW10 interactor Noelin-1 PF12308.6 NM_001293683.1_2 - 6.6 6.7 9.5 11 5.9 2.6 2.4 1 1 1 2 2 2 0 Neurogenesis glycoprotein DUF2524 PF10732.7 NM_001293683.1_2 - 7.1 6.9 17.4 11 6.3 12.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) HSR PF03172.11 NM_001271556.1_1 - 3.5e-24 84.7 0.0 4.8e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 HSR domain PHD PF00628.27 NM_001271556.1_1 - 6.3e-09 35.5 10.7 6.3e-09 35.5 10.7 2.0 2 0 0 2 2 2 1 PHD-finger SAND PF01342.19 NM_001271556.1_1 - 2.1e-06 27.2 0.0 4.3e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 SAND domain PHD_2 PF13831.4 NM_001271556.1_1 - 0.04 13.3 5.0 0.11 11.9 5.0 1.8 1 0 0 1 1 1 0 PHD-finger zf-PHD-like PF15446.4 NM_001271556.1_1 - 0.28 10.6 7.1 0.15 11.5 2.8 2.2 1 1 1 2 2 2 0 PHD/FYVE-zinc-finger like domain Myosin_head PF00063.19 NM_015742.2_3 - 6.1e-214 712.0 16.1 2.4e-182 607.6 2.7 2.5 3 0 0 3 3 3 2 Myosin head (motor domain) RhoGAP PF00620.25 NM_015742.2_3 - 1.1e-45 155.0 0.1 4.7e-45 153.0 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain RA PF00788.21 NM_015742.2_3 - 3.2e-18 66.0 2.8 3.1e-17 62.8 0.0 3.4 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain IQ PF00612.25 NM_015742.2_3 - 2.4e-16 57.8 22.9 0.00012 21.4 2.3 5.0 4 0 0 4 4 4 4 IQ calmodulin-binding motif C1_1 PF00130.20 NM_015742.2_3 - 1.3e-05 24.9 9.9 3e-05 23.7 9.9 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) AAA_22 PF13401.4 NM_015742.2_3 - 0.014 15.5 1.2 0.39 10.9 0.1 3.4 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.18 NM_015742.2_3 - 0.089 11.7 0.0 0.18 10.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.4 NM_015742.2_3 - 0.12 12.6 0.2 1 9.6 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain Zf_RING PF16744.3 NM_015742.2_3 - 0.19 11.7 5.9 0.46 10.5 5.9 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger zf-RING_9 PF13901.4 NM_015742.2_3 - 1.5 8.6 11.8 0.3 10.9 4.9 3.1 3 0 0 3 3 3 0 Putative zinc-RING and/or ribbon PDCD2_C PF04194.11 NM_015742.2_3 - 4.9 7.1 12.2 0.036 14.0 2.1 2.6 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain GPCR_chapero_1 PF11904.6 NM_172945.2_1 - 1.4e-101 339.8 0.0 1.8e-101 339.6 0.0 1.1 1 0 0 1 1 1 1 GPCR-chaperone Ank_2 PF12796.5 NM_172945.2_1 - 2.1e-17 63.4 0.0 7e-10 39.2 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 NM_172945.2_1 - 8.3e-11 41.8 0.2 1.7e-08 34.5 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_172945.2_1 - 5.3e-09 36.3 0.0 2.4e-08 34.2 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 NM_172945.2_1 - 1.4e-07 31.5 0.2 7.7e-06 26.0 0.1 3.3 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.4 NM_172945.2_1 - 1.2e-05 25.1 0.1 0.0037 17.5 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Pkinase_Tyr PF07714.15 NM_172891.2_3 - 2.6e-57 193.9 0.0 3.4e-57 193.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_172891.2_3 - 7.1e-29 100.8 0.0 1e-28 100.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 NM_172891.2_3 - 0.13 11.5 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like EF_assoc_2 PF08356.10 NM_001163355.1_2 - 3.2e-35 119.8 0.0 1.9e-34 117.4 0.0 2.4 2 0 0 2 2 2 1 EF hand associated EF_assoc_1 PF08355.10 NM_001163355.1_2 - 3.8e-29 100.0 1.7 1.2e-28 98.4 0.9 2.1 2 0 0 2 2 2 1 EF hand associated Ras PF00071.20 NM_001163355.1_2 - 8.5e-27 93.6 0.0 4.9e-19 68.4 0.0 2.5 2 0 0 2 2 2 2 Ras family Roc PF08477.11 NM_001163355.1_2 - 6.1e-11 42.5 0.0 4.9e-08 33.1 0.0 3.1 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001163355.1_2 - 1.1e-06 28.1 0.0 0.0005 19.4 0.0 3.1 3 0 0 3 3 3 1 ADP-ribosylation factor family EF-hand_7 PF13499.4 NM_001163355.1_2 - 1.3e-05 25.5 0.1 0.025 14.9 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair DUF258 PF03193.14 NM_001163355.1_2 - 4.2e-05 23.4 0.5 0.78 9.5 0.1 4.1 4 0 0 4 4 4 1 Protein of unknown function, DUF258 SRPRB PF09439.8 NM_001163355.1_2 - 4.5e-05 22.8 0.8 0.0005 19.4 0.0 2.4 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit EF-hand_1 PF00036.30 NM_001163355.1_2 - 6.3e-05 22.1 2.9 0.17 11.3 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 NM_001163355.1_2 - 8.6e-05 22.0 2.6 0.035 13.9 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain PduV-EutP PF10662.7 NM_001163355.1_2 - 0.00029 20.5 0.2 0.16 11.5 0.0 2.8 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.4 NM_001163355.1_2 - 0.003 17.7 0.0 1.5 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.4 NM_001163355.1_2 - 0.0038 17.5 0.0 0.54 10.5 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.21 NM_001163355.1_2 - 0.0052 16.7 0.1 0.062 13.3 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase Rad4 PF03835.13 NM_001163355.1_2 - 0.0068 15.9 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain RNA_helicase PF00910.20 NM_001163355.1_2 - 0.012 15.8 0.0 6.2 7.1 0.0 3.2 3 0 0 3 3 3 0 RNA helicase Septin PF00735.16 NM_001163355.1_2 - 0.016 14.3 0.0 4.1 6.4 0.0 2.3 2 0 0 2 2 2 0 Septin ABC_tran PF00005.25 NM_001163355.1_2 - 0.031 14.6 0.0 13 6.1 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_14 PF13173.4 NM_001163355.1_2 - 0.036 14.0 0.0 6.2 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain EF-hand_8 PF13833.4 NM_001163355.1_2 - 0.11 12.1 0.6 2.3 7.9 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain pair AAA PF00004.27 NM_001163355.1_2 - 0.14 12.5 0.0 4.3 7.6 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 NM_001163355.1_2 - 0.15 11.9 0.2 3.8 7.4 0.0 2.5 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Dynamin_N PF00350.21 NM_001163355.1_2 - 0.17 11.8 0.1 15 5.5 0.0 2.4 2 0 0 2 2 2 0 Dynamin family EF-hand_5 PF13202.4 NM_001163355.1_2 - 0.4 10.2 2.5 4.4 6.9 0.1 2.5 2 0 0 2 2 2 0 EF hand Bcl-2 PF00452.17 NM_009741.5_1 - 5.1e-31 107.1 0.1 8.3e-31 106.4 0.1 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.15 NM_009741.5_1 - 6.4e-13 48.1 0.3 1.4e-12 47.0 0.3 1.6 1 0 0 1 1 1 1 Bcl-2 homology region 4 Bcl-2_3 PF15286.4 NM_009741.5_1 - 0.078 13.5 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like COesterase PF00135.26 NM_001190330.1_1 - 1.4e-151 505.8 0.0 9e-101 338.2 0.1 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.11 NM_001190330.1_1 - 8.9e-10 38.6 0.3 4.2e-09 36.4 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 NM_001190330.1_1 - 1.7e-05 24.2 0.1 2.8e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family HECT PF00632.23 NM_001001883.3_2 - 3.7e-104 348.4 0.0 5.1e-104 347.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HECW_N PF16562.3 NM_001001883.3_2 - 2.2e-58 195.1 0.0 3.4e-58 194.5 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 WW PF00397.24 NM_001001883.3_2 - 1.8e-17 62.8 0.4 1.4e-09 37.6 0.3 2.5 2 0 0 2 2 2 2 WW domain C2 PF00168.28 NM_001001883.3_2 - 2.2e-11 43.8 0.0 4.6e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain Cep57_CLD PF14073.4 NM_001001883.3_2 - 0.049 13.5 0.2 0.12 12.2 0.2 1.6 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 PAP2 PF01569.19 NM_001170935.1_1 - 5.7e-14 51.9 6.0 1.1e-13 51.0 6.0 1.4 1 0 0 1 1 1 1 PAP2 superfamily Pkinase PF00069.23 NM_001159631.1_2 - 9.7e-64 215.1 0.0 1.4e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001159631.1_2 - 5e-46 157.0 0.0 7e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001159631.1_2 - 0.00012 21.4 0.0 0.00022 20.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_001159631.1_2 - 0.017 14.3 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IBN_N PF03810.17 NM_181517.3_1 - 7.6e-23 80.1 0.1 3.1e-21 74.9 0.0 3.6 3 1 1 4 4 4 1 Importin-beta N-terminal domain Cse1 PF08506.8 NM_181517.3_1 - 5.1e-09 35.2 1.5 5.1e-09 35.2 1.5 2.5 2 1 0 2 2 2 1 Cse1 Xpo1 PF08389.10 NM_181517.3_1 - 0.0018 18.2 8.9 0.0032 17.4 1.4 4.2 4 1 1 5 5 5 1 Exportin 1-like protein RIX1 PF08167.10 NM_181517.3_1 - 0.0065 16.1 0.3 2.2 7.9 0.1 4.0 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis RRN3 PF05327.9 NM_181517.3_1 - 0.0073 14.8 10.0 0.57 8.5 0.0 3.2 3 0 0 3 3 3 2 RNA polymerase I specific transcription initiation factor RRN3 DUF3730 PF12530.6 NM_181517.3_1 - 0.013 14.9 0.2 0.013 14.9 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3730) DUF2457 PF10446.7 NM_181517.3_1 - 4.6 6.2 15.9 6.6 5.6 15.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) 7tm_4 PF13853.4 NM_146608.1_1 - 3.7e-42 144.9 16.5 4.5e-42 144.6 16.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146608.1_1 - 8.3e-20 71.0 16.2 2.4e-19 69.5 16.2 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146608.1_1 - 0.00059 19.2 16.8 0.00098 18.4 16.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SK_channel PF03530.12 NM_146608.1_1 - 0.021 14.6 1.2 0.021 14.6 1.2 2.5 2 1 0 2 2 2 0 Calcium-activated SK potassium channel zf-H2C2_2 PF13465.4 NM_001085546.2_2 - 2.1e-29 100.5 23.9 3e-10 40.0 1.2 5.3 5 0 0 5 5 5 4 Zinc-finger double domain KRAB PF01352.25 NM_001085546.2_2 - 5.7e-22 77.0 0.1 8.2e-22 76.5 0.1 1.3 1 0 0 1 1 1 1 KRAB box zf-C2H2 PF00096.24 NM_001085546.2_2 - 2.2e-18 65.4 23.1 6.4e-07 29.4 0.6 4.5 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001085546.2_2 - 2.5e-13 49.5 22.2 7.8e-05 23.0 0.4 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001085546.2_2 - 3.4e-10 39.5 25.8 4.3e-06 26.4 0.3 4.7 4 1 0 4 4 4 3 C2H2-type zinc finger GATA PF00320.25 NM_001085546.2_2 - 0.0017 17.8 5.6 2.4 7.7 0.1 3.6 3 0 0 3 3 3 2 GATA zinc finger zf-LYAR PF08790.9 NM_001085546.2_2 - 0.0034 17.1 12.3 1.5 8.7 0.2 4.9 4 0 0 4 4 4 1 LYAR-type C2HC zinc finger zf-C2H2_jaz PF12171.6 NM_001085546.2_2 - 0.0056 16.8 21.8 0.17 12.1 0.4 4.0 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001085546.2_2 - 0.0079 16.2 15.2 0.18 11.8 6.0 3.4 2 1 1 3 3 3 3 Zinc ribbon domain XPA_N PF01286.16 NM_001085546.2_2 - 0.013 15.4 11.7 2.1 8.3 0.2 4.1 4 0 0 4 4 4 0 XPA protein N-terminal DUF3268 PF11672.6 NM_001085546.2_2 - 0.016 15.4 0.8 0.016 15.4 0.8 2.3 1 1 2 3 3 3 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 NM_001085546.2_2 - 0.032 14.9 2.9 0.032 14.9 2.9 2.4 1 1 1 2 2 2 0 zinc-ribbon family Vitellogenin_N PF01347.20 NM_001085546.2_2 - 0.067 11.4 0.9 0.077 11.2 0.9 1.1 1 0 0 1 1 1 0 Lipoprotein amino terminal region zf-ribbon_3 PF13248.4 NM_001085546.2_2 - 0.084 12.2 9.0 0.59 9.5 0.1 3.8 4 0 0 4 4 3 0 zinc-ribbon domain RNA_POL_M_15KD PF02150.14 NM_001085546.2_2 - 0.11 12.3 7.4 21 4.9 0.0 4.2 4 0 0 4 4 4 0 RNA polymerases M/15 Kd subunit Ribosomal_L37ae PF01780.17 NM_001085546.2_2 - 0.13 12.2 12.3 4.7 7.2 4.8 2.9 1 1 1 2 2 2 0 Ribosomal L37ae protein family zf-BED PF02892.13 NM_001085546.2_2 - 0.55 10.2 15.1 7.4 6.6 1.0 3.8 1 1 2 3 3 3 0 BED zinc finger BolA PF01722.16 NM_001085546.2_2 - 0.56 10.4 5.5 7.4 6.8 1.3 2.4 2 0 0 2 2 2 0 BolA-like protein DUF2256 PF10013.7 NM_001085546.2_2 - 0.58 10.2 5.1 21 5.2 0.1 3.8 4 0 0 4 4 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2HC_2 PF13913.4 NM_001085546.2_2 - 0.58 10.0 12.8 1.8 8.4 0.1 4.5 4 0 0 4 4 4 0 zinc-finger of a C2HC-type YhfH PF14149.4 NM_001085546.2_2 - 0.77 9.6 9.9 29 4.6 0.3 3.9 4 0 0 4 4 4 0 YhfH-like protein zf-AN1 PF01428.14 NM_001085546.2_2 - 1.7 8.7 16.6 6.9 6.8 0.2 3.8 3 1 0 3 3 3 0 AN1-like Zinc finger CpXC PF14353.4 NM_001085546.2_2 - 1.9 8.4 11.0 3.2 7.7 1.2 3.3 3 0 0 3 3 3 0 CpXC protein RIG-I_C-RD PF11648.6 NM_001085546.2_2 - 2.4 8.3 11.8 7.1 6.8 0.1 4.1 4 0 0 4 4 4 0 C-terminal domain of RIG-I C1_4 PF07975.10 NM_001085546.2_2 - 2.7 8.2 15.7 1.7 8.8 3.9 2.7 1 1 2 3 3 3 0 TFIIH C1-like domain zf-CHY PF05495.10 NM_001085546.2_2 - 3.7 8.0 21.6 1.2 9.6 6.6 2.6 1 1 1 2 2 2 0 CHY zinc finger zf-met PF12874.5 NM_001085546.2_2 - 5.1 7.5 15.1 8.7 6.7 0.3 3.8 3 1 0 3 3 3 0 Zinc-finger of C2H2 type zf-trcl PF13451.4 NM_001085546.2_2 - 6.2 6.7 14.5 6.1 6.7 0.3 3.9 3 1 0 3 3 3 0 Probable zinc-ribbon domain HypA PF01155.17 NM_001085546.2_2 - 7.4 6.5 13.3 7e+02 0.1 13.2 2.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_11 PF16622.3 NM_001085546.2_2 - 7.7 6.2 13.7 5.8 6.6 0.0 4.0 4 0 0 4 4 4 0 zinc-finger C2H2-type PknG_rubred PF16919.3 NM_001085546.2_2 - 8.2 6.4 10.8 4.7 7.2 2.3 2.5 1 1 1 2 2 2 0 Protein kinase G rubredoxin domain zf-C2HE PF16278.3 NM_001085546.2_2 - 8.3 6.8 16.9 2.6 8.4 1.3 3.6 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Phosducin PF02114.14 NM_026176.3_1 - 9.3e-158 522.9 1.4 1.2e-157 522.6 1.4 1.1 1 0 0 1 1 1 1 Phosducin CSD PF00313.20 NM_001310693.1_2 - 1e-68 226.9 15.7 3e-17 62.1 0.2 9.1 9 0 0 9 9 9 7 'Cold-shock' DNA-binding domain S1-like PF14444.4 NM_001310693.1_2 - 8.5e-12 44.8 9.9 0.071 13.0 0.0 6.2 6 0 0 6 6 6 4 S1-like SUZ-C PF12901.5 NM_001310693.1_2 - 2e-10 40.3 0.5 9.4e-10 38.2 0.0 2.2 2 0 0 2 2 2 1 SUZ-C motif CusF_Ec PF11604.6 NM_001310693.1_2 - 1.8e-05 24.5 10.0 0.13 12.1 0.0 6.8 7 0 0 7 7 7 1 Copper binding periplasmic protein CusF RsgA_N PF16745.3 NM_001310693.1_2 - 0.054 13.1 6.7 6 6.6 0.0 5.2 6 0 0 6 6 6 0 RsgA N-terminal domain HasA PF06438.10 NM_001310693.1_2 - 0.099 12.1 0.1 1 8.8 0.1 2.4 2 1 1 3 3 3 0 Heme-binding protein A (HasA) PAP2 PF01569.19 NM_008903.2_1 - 6e-27 93.9 0.6 1.2e-26 93.0 0.6 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 NM_008903.2_1 - 0.005 17.2 2.2 0.014 15.7 2.2 1.8 1 0 0 1 1 1 1 PAP2 superfamily C-terminal ACC_central PF08326.10 NM_133904.2_1 - 6.2e-285 946.8 4.5 7.8e-285 946.5 4.5 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.20 NM_133904.2_1 - 4.9e-178 592.7 0.0 6.4e-178 592.3 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.15 NM_133904.2_1 - 2.6e-50 170.7 0.0 5.2e-50 169.8 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.20 NM_133904.2_1 - 6.2e-31 107.1 0.0 1.4e-30 105.9 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.17 NM_133904.2_1 - 3.1e-23 81.8 0.0 2.3e-22 79.0 0.0 2.5 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.20 NM_133904.2_1 - 3.4e-16 58.7 0.2 8.4e-16 57.4 0.2 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.20 NM_133904.2_1 - 0.004 16.6 0.0 0.0081 15.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.11 NM_133904.2_1 - 0.022 14.2 0.0 0.081 12.3 0.0 1.9 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.4 NM_133904.2_1 - 0.027 14.2 0.0 0.28 10.9 0.0 2.5 2 0 0 2 2 2 0 Biotin-lipoyl like ATP-grasp_3 PF02655.12 NM_133904.2_1 - 0.066 13.1 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain Integrin_beta PF00362.16 NM_008405.3_1 - 4.1e-62 210.0 0.1 6.7e-49 166.7 0.0 2.2 1 1 1 2 2 2 2 Integrin beta chain VWA domain PSI_integrin PF17205.1 NM_008405.3_1 - 8.6e-15 54.2 8.1 8.6e-15 54.2 8.1 3.4 2 0 0 2 2 2 1 Integrin plexin domain EGF_2 PF07974.11 NM_008405.3_1 - 7.5e-08 32.5 82.2 0.0002 21.5 10.3 6.5 4 2 1 5 5 5 4 EGF-like domain Tmemb_9 PF05434.9 NM_008405.3_1 - 0.74 9.5 0.0 0.74 9.5 0.0 3.6 3 1 1 4 4 4 0 TMEM9 CN_hydrolase PF00795.20 NM_025295.4_3 - 2.3e-14 53.2 0.0 3.6e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Sel1 PF08238.10 NM_027250.4_1 - 1.1e-09 38.5 5.2 0.16 12.6 0.0 4.6 4 0 0 4 4 4 4 Sel1 repeat Ras PF00071.20 NM_080726.3_2 - 1.5e-28 99.3 0.0 1.9e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_080726.3_2 - 9.4e-09 35.4 0.0 1.3e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF258 PF03193.14 NM_080726.3_2 - 0.00012 21.9 0.0 0.069 12.9 0.2 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_5 PF07728.12 NM_080726.3_2 - 0.0033 17.3 0.0 0.0058 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Septin PF00735.16 NM_080726.3_2 - 0.0054 15.9 0.0 0.0075 15.4 0.0 1.1 1 0 0 1 1 1 1 Septin Arf PF00025.19 NM_080726.3_2 - 0.0058 16.0 0.0 0.0093 15.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family ABC_tran PF00005.25 NM_080726.3_2 - 0.016 15.6 0.0 0.029 14.8 0.0 1.3 1 0 0 1 1 1 0 ABC transporter FeoB_N PF02421.16 NM_080726.3_2 - 0.032 13.6 0.0 1.5 8.2 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_16 PF13191.4 NM_080726.3_2 - 0.039 14.2 0.4 0.1 12.8 0.4 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.4 NM_080726.3_2 - 0.048 13.3 0.2 0.13 11.9 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.4 NM_080726.3_2 - 0.052 13.7 0.1 0.2 11.8 0.1 2.0 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.21 NM_080726.3_2 - 0.096 12.7 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.4 NM_080726.3_2 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Homeobox PF00046.27 NM_027802.2_3 - 1.7e-17 62.8 2.1 2.7e-17 62.2 2.1 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 NM_027802.2_3 - 0.098 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Homeobox KN domain Gram_pos_anchor PF00746.19 NM_009704.4_2 - 0.31 10.9 2.2 0.53 10.2 2.2 1.3 1 0 0 1 1 1 0 Gram positive anchor FtsL PF04999.11 NM_009704.4_3 - 0.0084 15.9 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Cell division protein FtsL Rieske PF00355.24 NM_009704.4_3 - 0.021 14.6 1.3 0.036 13.9 1.3 1.3 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain EGF PF00008.25 NM_009704.4_3 - 0.41 10.9 5.1 0.78 10.0 5.1 1.5 1 0 0 1 1 1 0 EGF-like domain Ion_trans PF00520.29 NM_029772.4_3 - 1.6e-28 99.5 21.3 4e-28 98.2 21.4 1.6 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.10 NM_029772.4_3 - 6.1e-05 21.7 8.9 6.1e-05 21.7 8.9 2.3 1 1 0 2 2 2 2 Polycystin cation channel Ribosomal_S24e PF01282.17 NM_029772.4_3 - 0.11 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S24e Tetraspannin PF00335.18 NM_029772.4_3 - 9 5.9 9.3 4.6 6.9 6.0 2.2 2 1 0 2 2 2 0 Tetraspanin family Ank_2 PF12796.5 NM_001310521.1_1 - 2.9e-37 127.0 7.8 3e-14 53.2 0.1 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_001310521.1_1 - 7.4e-24 83.7 2.4 7e-11 42.3 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_001310521.1_1 - 5.2e-22 77.1 8.6 6.2e-06 26.3 0.1 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.4 NM_001310521.1_1 - 6.2e-22 77.2 5.9 6.7e-11 42.1 0.2 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 NM_001310521.1_1 - 2.5e-21 73.3 5.1 0.00049 20.2 0.1 5.4 5 0 0 5 5 5 4 Ankyrin repeat SAM_1 PF00536.28 NM_175021.3_3 - 2e-10 40.8 0.2 3.8e-10 39.9 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PHAT PF09246.8 NM_175021.3_3 - 1.2e-07 31.4 0.0 0.0088 15.7 0.0 3.3 3 0 0 3 3 3 3 PHAT SAM_2 PF07647.15 NM_175021.3_3 - 0.00019 21.4 0.1 0.00043 20.2 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Syndecan PF01034.18 NM_174992.4_1 - 0.021 14.6 0.1 0.033 14.0 0.1 1.2 1 0 0 1 1 1 0 Syndecan domain SUIM_assoc PF16619.3 NM_028317.2_1 - 1.8 8.6 5.6 1.6 8.8 2.9 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF4584 PF15223.4 NM_028317.2_3 - 1.3e-180 601.1 7.8 1.3e-180 601.1 7.8 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4584) Ski_Sno PF02437.15 NM_028317.2_3 - 3.8e-14 52.2 0.0 7.1e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 SKI/SNO/DAC family Nop14 PF04147.10 NM_028317.2_3 - 0.19 9.8 11.8 0.29 9.2 11.8 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.10 NM_028317.2_3 - 2.3 7.5 17.1 0.11 11.8 11.6 1.5 2 0 0 2 2 2 0 SDA1 BUD22 PF09073.8 NM_028317.2_3 - 3.6 6.7 16.1 6.3 5.9 16.1 1.3 1 0 0 1 1 1 0 BUD22 zf-AN1 PF01428.14 NM_026846.3_1 - 1.4e-21 76.2 25.6 1.7e-10 40.7 7.0 2.8 2 0 0 2 2 2 2 AN1-like Zinc finger Transp_Tc5_C PF04236.13 NM_026846.3_1 - 0.00018 21.7 13.1 0.015 15.5 1.9 2.6 2 0 0 2 2 2 2 Tc5 transposase C-terminal domain UIM PF02809.18 NM_026846.3_1 - 0.00078 19.1 5.4 0.00078 19.1 5.4 2.8 2 0 0 2 2 2 1 Ubiquitin interaction motif zf-C5HC2 PF02928.14 NM_026846.3_1 - 2.2 8.6 11.9 3.1 8.1 2.2 2.8 2 0 0 2 2 2 0 C5HC2 zinc finger HLH PF00010.24 NM_016968.4_1 - 4.7e-12 45.6 0.5 9.5e-12 44.6 0.5 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF1283 PF06932.9 NM_016968.4_1 - 0.058 13.5 0.1 0.1 12.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1283) Ig_3 PF13927.4 NM_207676.2_1 - 8.9e-27 93.4 0.2 1.4e-11 44.7 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_207676.2_1 - 4.7e-24 84.4 0.4 6.8e-09 35.8 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_207676.2_1 - 8.2e-23 80.2 0.2 3.9e-10 39.5 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 NM_207676.2_1 - 1.1e-19 70.3 1.4 6.3e-08 32.6 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_207676.2_1 - 1.3e-14 54.2 3.3 5.1e-07 29.7 0.1 4.3 3 1 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_207676.2_1 - 9.9e-14 51.1 0.0 6.7e-13 48.4 0.0 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 NM_207676.2_1 - 0.00043 20.1 0.2 1.6 8.7 0.0 3.0 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain C1-set PF07654.13 NM_207676.2_1 - 0.001 19.4 0.3 0.028 14.8 0.1 2.9 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Adeno_E3_CR1 PF02440.13 NM_207676.2_1 - 0.18 11.4 2.2 13 5.5 0.0 3.3 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 OAD_gamma PF04277.11 NM_207676.2_1 - 3.4 8.2 0.0 3.4 8.2 0.0 3.1 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Zip PF02535.20 NM_026244.2_1 - 9.5e-36 123.5 23.8 1e-26 93.9 10.9 2.5 1 1 1 2 2 2 2 ZIP Zinc transporter SOXp PF12336.6 NM_009233.3_3 - 3e-31 108.2 3.8 1.3e-30 106.2 3.8 2.1 1 1 0 1 1 1 1 SOX transcription factor HMG_box PF00505.17 NM_009233.3_3 - 1.7e-26 92.2 4.1 2.8e-26 91.6 4.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_009233.3_3 - 3.4e-10 40.3 3.4 3.4e-10 40.3 3.4 1.6 2 0 0 2 2 2 1 HMG-box domain Zwint PF15556.4 NM_001293684.1_2 - 1.1e-80 270.6 31.9 1.5e-80 270.2 31.9 1.1 1 0 0 1 1 1 1 ZW10 interactor DUF2524 PF10732.7 NM_001293684.1_2 - 7 6.9 17.4 11 6.3 12.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) Noelin-1 PF12308.6 NM_001293684.1_2 - 7.2 6.5 9.5 11 5.9 2.6 2.3 1 1 1 2 2 2 0 Neurogenesis glycoprotein SRTM1 PF15872.3 NM_177854.4_3 - 2e-53 178.7 13.0 4.3e-53 177.6 13.0 1.5 1 0 0 1 1 1 1 Serine-rich and transmembrane domain-containing protein 1 TLE_N PF03920.13 NM_001285530.1_1 - 3.1e-71 237.4 4.6 4.8e-71 236.8 4.6 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.30 NM_001285530.1_1 - 3.2e-11 43.5 18.7 0.086 13.6 0.8 7.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001285530.1_1 - 5.8e-05 23.2 0.0 0.8 9.9 0.0 3.2 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain HMGL-like PF00682.17 NM_173731.2_3 - 1.1e-64 218.4 0.0 1.4e-64 218.1 0.0 1.1 1 0 0 1 1 1 1 HMGL-like TMEM173 PF15009.4 NM_001289592.1_3 - 9.9e-102 339.9 1.1 3.5e-97 325.0 0.0 2.3 1 1 1 2 2 2 2 Transmembrane protein 173 Proteasome PF00227.24 NM_013585.2_1 - 1.6e-42 145.0 0.1 2e-42 144.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Ctf8 PF09696.8 NM_145412.3_1 - 1.7e-06 28.3 0.1 1.9e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Ctf8 GST_N_3 PF13417.4 NM_010362.3_3 - 1.2e-19 70.3 0.0 3.5e-19 68.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 NM_010362.3_3 - 2.3e-14 53.4 0.0 5e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 NM_010362.3_3 - 1.2e-13 51.1 0.0 2.4e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 NM_010362.3_3 - 1.4e-08 34.7 0.1 2.5e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 NM_010362.3_3 - 1.2e-07 31.4 0.0 2e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_010362.3_3 - 0.00014 21.9 0.0 0.00033 20.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.22 NM_010362.3_3 - 0.0036 17.3 0.0 0.0078 16.3 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin 6PF2K PF01591.16 NM_133232.3_1 - 1.2e-106 354.9 0.2 1.7e-106 354.4 0.2 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 NM_133232.3_1 - 1.5e-39 135.6 0.0 2.1e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 NM_133232.3_1 - 7.9e-07 29.2 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 NM_133232.3_1 - 8.6e-05 22.0 0.1 0.00014 21.2 0.1 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Glyco_hydro_18 PF00704.26 NM_001142681.1_1 - 2.6e-18 66.7 0.0 3.3e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Peptidase_C1 PF00112.21 NM_027344.3_3 - 2e-84 283.0 1.9 2.8e-84 282.5 1.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 NM_027344.3_3 - 1.2e-10 41.6 4.8 2e-10 40.8 4.8 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 NM_027344.3_3 - 3.2e-07 29.4 1.0 5e-05 22.1 0.3 2.2 2 0 0 2 2 2 2 Peptidase C1-like family KH_1 PF00013.27 NM_057172.3_1 - 1.9e-67 222.9 14.4 8.6e-18 63.8 0.1 4.2 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 NM_057172.3_1 - 1.2e-20 73.0 9.3 1.9e-05 24.3 0.0 4.2 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.8 NM_057172.3_1 - 2.5e-11 42.7 20.1 4.3e-07 29.2 3.7 3.6 3 0 0 3 3 3 2 Domain of unknown function (DUF1897) KH_4 PF13083.4 NM_057172.3_1 - 2e-06 27.5 11.0 0.15 11.8 0.1 4.2 4 0 0 4 4 4 3 KH domain Secretin_N PF03958.15 NM_057172.3_1 - 0.035 14.4 0.5 0.54 10.6 0.4 2.5 2 1 0 2 2 2 0 Bacterial type II/III secretion system short domain KH_5 PF13184.4 NM_057172.3_1 - 2.4 8.2 10.9 18 5.4 0.1 4.0 4 0 0 4 4 4 0 NusA-like KH domain Hist_deacetyl PF00850.17 NM_001204277.1_1 - 1.2e-77 261.3 0.0 1.7e-77 260.8 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain DUF1041 PF06292.15 NM_001252106.1_3 - 3e-37 127.0 0.6 7.5e-37 125.7 0.6 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) PH PF00169.27 NM_001252106.1_3 - 1.5e-05 25.3 0.1 3.3e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 PH domain WD40 PF00400.30 NM_026550.3_3 - 3.7e-19 68.6 20.1 1.1e-05 26.0 0.3 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_026550.3_3 - 4.6e-09 36.3 0.9 0.007 16.5 0.3 3.8 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_026550.3_3 - 5.4e-05 23.0 0.1 0.013 15.3 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.3 NM_026550.3_3 - 0.0006 19.1 0.0 0.073 12.3 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.3 NM_026550.3_3 - 0.0027 16.6 0.5 1.9 7.3 0.1 2.9 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-HC5HC2H_2 PF13832.4 NM_001033274.3_3 - 6.4e-37 126.0 4.1 6.4e-37 126.0 4.1 2.7 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.7 NM_001033274.3_3 - 8.6e-34 117.1 1.3 8.6e-34 117.1 1.3 1.9 2 0 0 2 2 2 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.4 NM_001033274.3_3 - 4e-26 90.9 2.5 4e-26 90.9 2.5 3.7 3 0 0 3 3 3 1 PHD-like zinc-binding domain Bromodomain PF00439.23 NM_001033274.3_3 - 2.9e-25 88.0 0.2 5.8e-25 87.1 0.2 1.5 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.15 NM_001033274.3_3 - 6.1e-14 52.1 0.5 2.1e-13 50.4 0.0 2.2 2 0 0 2 2 2 1 PWWP domain PHD_2 PF13831.4 NM_001033274.3_3 - 2.9e-13 49.0 4.4 2.9e-13 49.0 4.4 2.8 2 0 0 2 2 2 1 PHD-finger PHD PF00628.27 NM_001033274.3_3 - 1.9e-06 27.6 27.9 5e-06 26.2 13.5 2.9 2 0 0 2 2 2 2 PHD-finger AAA_23 PF13476.4 NM_001033274.3_3 - 0.43 10.9 4.7 0.52 10.7 1.0 2.4 2 0 0 2 2 2 0 AAA domain DNA_topoisoIV PF00521.18 NM_001033274.3_3 - 0.82 8.3 3.5 1.3 7.6 3.5 1.3 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A C1_2 PF03107.14 NM_001033274.3_3 - 7.8 6.8 20.1 5.5 7.3 4.4 3.0 2 0 0 2 2 2 0 C1 domain Cadherin PF00028.15 NM_001024478.1_3 - 4.6e-51 171.1 2.3 7e-14 51.9 0.1 6.6 6 1 0 6 6 6 6 Cadherin domain Cadherin_3 PF16184.3 NM_001024478.1_3 - 2.4e-06 27.4 0.8 0.048 13.5 0.0 3.8 4 0 0 4 4 4 2 Cadherin-like Cadherin_2 PF08266.10 NM_001024478.1_3 - 2.7e-05 23.7 0.0 0.00082 19.0 0.0 3.1 3 1 0 3 3 3 1 Cadherin-like PQQ PF01011.19 NM_001024478.1_3 - 0.025 14.4 0.1 0.089 12.6 0.0 2.1 2 0 0 2 2 2 0 PQQ enzyme repeat DUF4212 PF13937.4 NM_001085501.2_1 - 0.12 12.7 0.3 0.21 11.8 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) CBM_21 PF03370.11 NM_001085501.2_2 - 2.5e-26 91.9 0.0 3.6e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 NM_001085501.2_2 - 8.2e-12 45.4 0.0 1.4e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Clat_adaptor_s PF01217.18 NM_007457.2_3 - 1.1e-60 203.5 1.9 1.4e-60 203.2 1.9 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SR-25 PF10500.7 NM_175279.3_2 - 0.025 14.1 4.8 0.044 13.3 4.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RA PF00788.21 NM_175279.3_2 - 0.08 13.5 0.0 0.91 10.1 0.0 2.3 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain FliJ PF02050.14 NM_175279.3_2 - 0.73 9.9 18.2 0.033 14.3 2.0 3.2 3 1 0 3 3 3 0 Flagellar FliJ protein FUSC PF04632.10 NM_175279.3_2 - 9.5 4.5 9.7 6.8 5.0 7.6 1.6 1 1 0 1 1 1 0 Fusaric acid resistance protein family ubiquitin PF00240.21 NM_001171739.1_3 - 4.3e-07 29.4 2.5 4.7e-07 29.3 0.0 2.4 3 0 0 3 3 3 1 Ubiquitin family BAG PF02179.14 NM_001171739.1_3 - 1.5e-05 25.2 4.8 1.5e-05 25.2 4.8 1.9 2 0 0 2 2 2 1 BAG domain YbgS PF13985.4 NM_001171739.1_3 - 0.49 10.6 3.8 1.6 8.9 3.4 1.9 1 1 0 1 1 1 0 YbgS-like protein DUF4614 PF15391.4 NM_001171739.1_3 - 8.3 6.2 12.4 13 5.6 12.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4614) Porin_3 PF01459.20 NM_001109748.1_2 - 1.4e-77 260.7 0.2 1.7e-77 260.4 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin ACBP PF00887.17 NM_021294.2_2 - 2.7e-22 78.7 0.4 3.6e-22 78.2 0.4 1.2 1 0 0 1 1 1 1 Acyl CoA binding protein MCM_bind PF09739.7 NM_021294.2_2 - 0.072 11.4 0.0 0.096 11.0 0.0 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor F-box-like PF12937.5 NM_001303004.1_2 - 2.5e-12 46.3 0.3 4.9e-12 45.4 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_001303004.1_2 - 6.2e-09 35.4 0.2 1.6e-08 34.1 0.1 1.8 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.3 NM_001303004.1_2 - 0.0028 17.4 0.4 0.0028 17.4 0.4 2.1 3 0 0 3 3 3 1 F-box 7tm_4 PF13853.4 NM_147070.2_1 - 5.1e-120 400.3 19.7 5.9e-120 400.1 19.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147070.2_1 - 5e-16 58.6 22.2 1.5e-15 57.1 22.2 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147070.2_1 - 1.4e-09 37.6 11.7 1.4e-09 37.6 11.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CUB PF00431.18 NM_001190313.1_1 - 1.9e-52 176.1 0.0 3.1e-27 95.0 0.0 2.3 2 0 0 2 2 2 2 CUB domain C1q PF00386.19 NM_001190313.1_1 - 1.3e-35 122.3 0.0 1.8e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 C1q domain Fz PF01392.20 NM_001190313.1_1 - 1.3e-21 77.3 2.8 1.3e-21 77.3 2.8 2.3 2 0 0 2 2 2 1 Fz domain Collagen PF01391.16 NM_001190313.1_1 - 4.5e-10 39.0 59.9 4.5e-07 29.4 27.7 3.0 2 1 1 3 3 3 2 Collagen triple helix repeat (20 copies) Ldl_recept_a PF00057.16 NM_001190313.1_1 - 2.6e-08 33.8 8.1 2.6e-08 33.8 8.1 3.4 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A CUB_2 PF02408.18 NM_001190313.1_1 - 4.6e-06 26.3 0.1 0.02 14.5 0.0 2.7 2 0 0 2 2 2 2 CUB-like domain Phage_holin_3_6 PF07332.9 NM_001190313.1_1 - 0.077 12.9 0.2 0.15 12.0 0.2 1.4 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III TB2_DP1_HVA22 PF03134.17 NM_007874.3_2 - 8e-30 102.5 1.8 1.7e-29 101.4 1.8 1.6 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Phage_holin_3_6 PF07332.9 NM_007874.3_2 - 0.066 13.1 0.2 0.14 12.1 0.2 1.4 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III HSBP1 PF06825.10 NM_024219.1_3 - 3.4e-27 94.0 8.0 5.5e-27 93.3 8.0 1.3 1 0 0 1 1 1 1 Heat shock factor binding protein 1 CLZ PF16526.3 NM_024219.1_3 - 0.1 12.9 0.1 0.17 12.2 0.1 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Pep_M12B_propep PF01562.17 NM_001326351.1_1 - 4.7e-37 127.2 0.1 1.5e-36 125.5 0.0 1.9 2 0 0 2 2 2 1 Reprolysin family propeptide ADAM_spacer1 PF05986.12 NM_001326351.1_1 - 4.2e-34 116.9 0.0 6.7e-34 116.2 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.17 NM_001326351.1_1 - 5e-32 109.8 121.4 1.7e-07 31.2 10.9 11.0 11 0 0 11 11 11 8 Thrombospondin type 1 domain Reprolysin PF01421.17 NM_001326351.1_1 - 1.3e-25 90.4 0.0 2.2e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 NM_001326351.1_1 - 8.1e-15 55.4 0.0 1.6e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 NM_001326351.1_1 - 1.1e-09 38.7 0.1 2.1e-09 37.8 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_001326351.1_1 - 2.2e-06 27.6 0.0 3.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 NM_001326351.1_1 - 0.0016 18.0 0.0 0.0027 17.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.9 NM_001326351.1_1 - 0.057 14.0 4.5 0.38 11.4 4.5 2.6 1 0 0 1 1 1 0 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.22 NM_001326351.1_1 - 0.13 12.0 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 Matrixin SAM_decarbox PF01536.14 NM_001326351.1_1 - 0.16 10.8 0.2 0.26 10.1 0.2 1.2 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase Serpin PF00079.18 NM_025429.2_2 - 1.9e-132 442.0 0.4 2.2e-132 441.7 0.4 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Jnk-SapK_ap_N PF09744.7 NM_001163448.1_1 - 1.4e-56 190.9 24.2 1.4e-56 190.9 24.2 3.0 3 1 0 3 3 3 1 JNK_SAPK-associated protein-1 JIP_LZII PF16471.3 NM_001163448.1_1 - 1.5e-28 98.6 9.7 1.5e-28 98.6 9.7 3.8 3 1 2 5 5 5 1 JNK-interacting protein leucine zipper II Golgin_A5 PF09787.7 NM_001163448.1_1 - 0.0092 15.3 31.0 0.0066 15.8 6.7 2.4 2 0 0 2 2 2 2 Golgin subfamily A member 5 ERM PF00769.17 NM_001163448.1_1 - 0.049 13.3 30.2 0.66 9.6 11.1 2.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Atg14 PF10186.7 NM_001163448.1_1 - 0.75 8.7 28.1 0.31 10.0 12.8 2.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 XhlA PF10779.7 NM_001163448.1_1 - 8.2 6.6 9.7 6.8 6.8 1.4 2.7 2 0 0 2 2 2 0 Haemolysin XhlA DUF1664 PF07889.10 NM_001163448.1_1 - 8.6 6.2 14.5 14 5.5 4.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4407 PF14362.4 NM_001163448.1_1 - 9.9 5.3 16.9 7.2 5.7 2.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) Synaptobrevin PF00957.19 NM_009498.4_1 - 3e-33 113.4 3.5 4.9e-33 112.6 3.5 1.4 1 0 0 1 1 1 1 Synaptobrevin SecE PF00584.18 NM_001109971.1_2 - 4.7e-14 51.9 0.1 6.7e-14 51.4 0.1 1.2 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex GST_N_3 PF13417.4 NM_133783.2_2 - 8.2e-11 42.0 0.0 4.1e-10 39.8 0.1 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.22 NM_133783.2_2 - 7.9e-08 32.3 0.2 1.6e-07 31.3 0.2 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.4 NM_133783.2_2 - 1.2e-07 31.8 0.0 5.4e-07 29.7 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.2 NM_133783.2_2 - 3.8e-05 24.2 0.0 8.6e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.4 NM_133783.2_2 - 0.00065 19.5 0.0 0.0014 18.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 NM_133783.2_2 - 0.075 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 NM_133783.2_2 - 0.085 13.1 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain 7tm_4 PF13853.4 NM_147059.1_1 - 2.1e-102 342.5 23.3 2.5e-102 342.2 23.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147059.1_1 - 6.4e-18 64.8 26.9 1.3e-17 63.8 26.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147059.1_1 - 3.2e-09 36.4 13.9 3.2e-09 36.4 13.9 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx EF-hand_7 PF13499.4 NM_016677.4_3 - 1.5e-26 92.5 6.4 3e-17 62.7 0.1 3.9 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.30 NM_016677.4_3 - 1.4e-24 83.6 4.5 1e-06 27.7 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 NM_016677.4_3 - 4.3e-21 72.9 2.7 2.2e-05 23.9 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.4 NM_016677.4_3 - 5.4e-20 69.8 2.4 9.2e-07 28.0 0.3 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 NM_016677.4_3 - 6.4e-17 60.9 5.2 1.5e-07 30.9 0.1 3.9 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 NM_016677.4_3 - 7.2e-06 26.2 0.4 0.0093 16.1 0.1 3.3 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_016677.4_3 - 8.7e-05 22.3 0.8 0.35 10.7 0.0 3.2 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.4 NM_016677.4_3 - 0.035 13.8 0.2 14 5.5 0.1 2.6 2 0 0 2 2 2 0 EF hand EF-hand_9 PF14658.4 NM_016677.4_3 - 0.065 13.4 0.1 5.4 7.3 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain zf-C3HC4_3 PF13920.4 NM_025999.3_2 - 1.9e-09 37.1 10.6 1.9e-09 37.1 10.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_025999.3_2 - 5.4e-09 36.0 14.4 5.4e-09 36.0 14.4 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 NM_025999.3_2 - 1.8e-08 33.9 13.6 1.8e-08 33.9 13.6 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_025999.3_2 - 2.5e-06 27.2 6.2 2.5e-06 27.2 6.2 2.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_025999.3_2 - 5e-06 26.2 13.2 5e-06 26.2 13.2 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_025999.3_2 - 2.5e-05 23.9 10.8 2.5e-05 23.9 10.8 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 NM_025999.3_2 - 0.0013 18.9 13.2 0.0013 18.9 13.2 2.0 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 NM_025999.3_2 - 0.0054 16.5 14.6 0.0054 16.5 14.6 2.7 2 1 1 3 3 3 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 NM_025999.3_2 - 0.62 10.0 8.7 1.8 8.5 8.6 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 NM_025999.3_2 - 1.6 8.4 15.7 3.5 7.3 12.6 2.8 2 1 0 2 2 2 0 RING-like zinc finger zf-C3HC4_5 PF17121.3 NM_025999.3_2 - 2.8 7.7 8.5 82 3.1 0.0 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 NM_025999.3_2 - 3 7.9 18.0 0.15 12.1 11.3 2.4 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF4559 PF15112.4 NM_175141.6_3 - 6.8e-100 334.6 0.1 9.1e-100 334.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4559) SK_channel PF03530.12 NM_032397.2_3 - 1e-46 157.5 0.3 1e-46 157.5 0.3 1.8 2 0 0 2 2 2 1 Calcium-activated SK potassium channel CaMBD PF02888.14 NM_032397.2_3 - 5.3e-34 116.2 6.3 9.4e-34 115.4 6.3 1.4 1 0 0 1 1 1 1 Calmodulin binding domain Ion_trans_2 PF07885.14 NM_032397.2_3 - 2.1e-12 46.7 3.0 2.1e-12 46.7 3.0 1.7 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.29 NM_032397.2_3 - 0.0042 16.2 1.6 0.0074 15.4 1.6 1.4 1 0 0 1 1 1 1 Ion transport protein DALR_1 PF05746.13 NM_032397.2_3 - 0.032 14.3 1.9 0.057 13.5 1.9 1.3 1 0 0 1 1 1 0 DALR anticodon binding domain Ribosomal_60s PF00428.17 NM_032397.2_3 - 0.19 12.2 2.8 0.47 10.9 2.8 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Seryl_tRNA_N PF02403.20 NM_032397.2_3 - 0.28 11.3 2.1 0.54 10.4 2.1 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF4140 PF13600.4 NM_032397.2_3 - 0.43 10.9 3.4 0.81 10.0 3.4 1.4 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) NAT PF04768.11 NM_145829.2_3 - 1.7e-47 161.1 0.0 2.4e-47 160.6 0.0 1.2 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase AA_kinase PF00696.26 NM_145829.2_3 - 0.00031 20.3 0.0 0.0005 19.6 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family UPF0197 PF05251.10 NM_001163431.1_3 - 1.3e-39 133.9 6.3 1.6e-39 133.6 6.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0197) Phage_holin_3_3 PF16083.3 NM_001163431.1_3 - 0.0099 15.9 0.7 0.015 15.3 0.7 1.3 1 0 0 1 1 1 1 LydA holin phage, holin superfamily III PGK PF00162.17 NM_008828.3_2 - 1.8e-149 497.7 0.3 2.1e-149 497.5 0.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF3172 PF11371.6 NM_008828.3_2 - 0.099 12.2 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3172) 7tm_4 PF13853.4 NM_146963.1_1 - 7.3e-50 170.1 14.7 9.5e-50 169.7 14.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146963.1_1 - 4.2e-21 75.3 18.6 7.4e-21 74.4 18.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146963.1_1 - 8.1e-07 28.5 5.7 8.1e-07 28.5 5.7 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx SLC3A2_N PF16028.3 NM_146963.1_1 - 0.13 11.7 0.6 0.28 10.6 0.1 1.8 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus AMP-binding PF00501.26 NM_001081426.2_2 - 6.1e-98 328.0 0.0 1e-74 251.5 0.0 2.5 2 1 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.9 NM_001081426.2_2 - 2.4e-36 124.8 1.1 4e-36 124.1 1.1 1.3 1 0 0 1 1 1 1 DMAP1-binding Domain GvpG PF05120.10 NM_001081426.2_2 - 0.003 17.4 0.1 0.0062 16.4 0.1 1.4 1 0 0 1 1 1 1 Gas vesicle protein G TPR_1 PF00515.26 NM_029321.2_1 - 3.1e-16 58.3 1.3 2e-08 33.5 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_029321.2_1 - 1.7e-13 49.4 2.9 1.6e-08 33.9 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.4 NM_029321.2_1 - 7.5e-11 41.4 2.2 0.0018 17.8 0.0 4.2 3 1 1 4 4 4 2 TPR repeat TPR_8 PF13181.4 NM_029321.2_1 - 1.1e-08 34.4 0.4 1.9e-05 24.4 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.4 NM_029321.2_1 - 5.7e-07 29.5 1.1 4.7e-05 23.3 0.0 2.4 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 NM_029321.2_1 - 6.6e-07 29.4 0.4 0.064 13.4 0.0 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.4 NM_029321.2_1 - 1.6e-06 28.3 2.2 0.052 14.2 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_029321.2_1 - 5.7e-05 23.6 4.3 0.11 13.1 0.1 2.5 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_19 PF14559.4 NM_029321.2_1 - 0.00015 22.0 0.4 0.31 11.4 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 NM_029321.2_1 - 0.00025 20.7 1.4 0.076 12.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.4 NM_029321.2_1 - 0.00081 19.5 0.4 5.1 7.6 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.7 NM_029321.2_1 - 0.00089 18.5 0.2 0.16 11.3 0.1 2.4 2 0 0 2 2 2 1 SHNi-TPR TPR_4 PF07721.12 NM_029321.2_1 - 0.0021 18.4 0.6 0.91 10.2 0.4 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.4 NM_029321.2_1 - 0.032 14.0 3.9 3.3 7.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 NM_029321.2_1 - 0.035 14.0 0.8 0.11 12.4 0.2 2.0 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.4 NM_029321.2_1 - 0.036 14.6 4.9 7.5 7.3 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Nup192 PF11894.6 NM_027513.1_2 - 0 1351.6 2.9 0 1351.2 2.9 1.1 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 An_peroxidase PF03098.13 NM_009417.3_2 - 1e-179 598.4 0.0 1.3e-179 598.0 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase EGF_CA PF07645.13 NM_009417.3_2 - 7e-11 42.0 6.3 7e-11 42.0 6.3 2.9 4 0 0 4 4 4 1 Calcium-binding EGF domain EGF_3 PF12947.5 NM_009417.3_2 - 1.4e-06 28.2 3.4 4.9e-06 26.5 3.4 1.9 1 0 0 1 1 1 1 EGF domain Sushi PF00084.18 NM_009417.3_2 - 5.3e-06 26.8 3.5 5.3e-06 26.8 3.5 2.2 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) Plasmod_Pvs28 PF06247.9 NM_009417.3_2 - 0.016 15.3 6.5 0.042 14.0 6.5 1.8 1 0 0 1 1 1 0 Pvs28 EGF domain cEGF PF12662.5 NM_009417.3_2 - 0.058 13.2 7.6 2.3 8.1 0.4 3.3 3 0 0 3 3 3 0 Complement Clr-like EGF-like DUF751 PF05421.9 NM_009417.3_2 - 0.75 10.4 3.9 1 9.9 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF751) hEGF PF12661.5 NM_009417.3_2 - 0.92 10.2 3.6 4.1 8.1 3.6 2.2 1 0 0 1 1 1 0 Human growth factor-like EGF Lectin_C PF00059.19 NM_001083322.2_3 - 1.3e-17 64.3 3.4 3e-17 63.2 3.4 1.6 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 NM_001083322.2_3 - 0.035 13.6 0.6 0.061 12.8 0.6 1.4 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like PARM PF17061.3 NM_145562.2_3 - 2.1e-115 385.8 32.9 2.7e-115 385.5 32.9 1.1 1 0 0 1 1 1 1 PARM Sulfatase PF00884.21 NM_009712.3_1 - 8.3e-75 251.9 0.0 1.1e-74 251.5 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.20 NM_009712.3_1 - 0.03 13.8 0.0 1.8 8.0 0.0 2.0 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4994 PF16385.3 NM_009712.3_1 - 0.16 11.8 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function Trypan_PARP PF05887.9 NM_009712.3_2 - 0.11 12.3 9.9 0.19 11.6 9.9 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MT-A70 PF05063.12 NM_019721.2_3 - 1.2e-60 204.2 0.0 2.1e-60 203.4 0.0 1.4 1 0 0 1 1 1 1 MT-A70 DUF445 PF04286.10 NM_019721.2_3 - 0.099 12.3 2.2 0.27 10.9 1.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF445) Phosphodiest PF01663.20 NM_020035.3_3 - 2e-15 57.1 0.1 3.8e-15 56.2 0.1 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.16 NM_020035.3_3 - 0.00015 21.1 0.2 0.00024 20.4 0.2 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.21 NM_020035.3_3 - 0.00041 19.7 0.0 0.0012 18.2 0.0 1.5 1 1 0 2 2 2 1 Sulfatase DUF1501 PF07394.10 NM_020035.3_3 - 0.16 10.9 0.4 0.26 10.2 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) PglZ PF08665.10 NM_020035.3_3 - 0.23 11.4 0.2 22 4.9 0.1 2.2 2 0 0 2 2 2 0 PglZ domain MAGE PF01454.17 NM_020018.1_2 - 5e-14 52.4 0.0 1e-11 44.8 0.0 2.5 2 1 0 2 2 2 1 MAGE family MAGE_N PF12440.6 NM_020018.1_2 - 6.5e-06 26.6 5.2 1.1e-05 25.9 5.2 1.3 1 0 0 1 1 1 1 Melanoma associated antigen family N terminal Pkinase_Tyr PF07714.15 NM_021099.3_2 - 9.5e-102 339.6 0.0 1.3e-101 339.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_021099.3_2 - 1.6e-42 145.6 0.0 8.7e-30 103.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 NM_021099.3_2 - 1.9e-26 92.4 11.6 4.7e-09 36.6 0.2 4.5 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 NM_021099.3_2 - 6.4e-15 54.9 6.2 6.3e-07 29.3 0.1 4.5 5 0 0 5 5 4 3 Immunoglobulin I-set domain ig PF00047.23 NM_021099.3_2 - 4.3e-13 49.1 0.7 4.3e-13 49.1 0.7 4.2 5 0 0 5 5 5 1 Immunoglobulin domain Ig_2 PF13895.4 NM_021099.3_2 - 5.9e-08 32.8 6.0 0.018 15.2 0.2 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Ig_5 PF16681.3 NM_021099.3_2 - 0.00052 20.3 0.2 1.5 9.1 0.0 2.7 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 NM_021099.3_2 - 0.0014 18.8 0.3 0.95 9.7 0.1 2.8 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain V-set PF07686.15 NM_021099.3_2 - 0.017 15.1 11.1 0.019 15.0 0.3 4.1 4 1 1 5 5 5 0 Immunoglobulin V-set domain APH PF01636.21 NM_021099.3_2 - 0.18 11.6 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family C1-set PF07654.13 NM_021099.3_2 - 1.1 9.6 6.5 0.11 12.8 0.5 2.5 3 0 0 3 3 3 0 Immunoglobulin C1-set domain PUF PF00806.17 NM_001160221.1_2 - 1.6e-71 232.0 10.0 2e-09 36.5 0.0 9.1 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.9 NM_001160221.1_2 - 0.085 13.1 1.2 8.6 6.6 0.1 3.5 1 1 1 2 2 2 0 CPL (NUC119) domain PC4 PF02229.14 NM_001160221.1_2 - 0.13 11.8 0.3 0.3 10.6 0.3 1.5 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) Cornifin PF02389.13 NM_027304.2_1 - 0.54 10.3 16.0 6.3 6.9 16.0 2.3 1 1 0 1 1 1 0 Cornifin (SPRR) family Pkinase PF00069.23 NM_010432.2_2 - 9.5e-50 169.3 0.0 1.4e-49 168.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_010432.2_2 - 1.3e-23 83.4 0.0 2e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_010432.2_2 - 0.00012 21.3 0.0 0.00023 20.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_010432.2_2 - 0.056 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Trypsin PF00089.24 NM_173864.2_1 - 7.6e-59 199.1 0.0 1.1e-58 198.6 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 NM_173864.2_1 - 7.6e-42 142.0 0.1 6.2e-23 81.1 0.0 2.4 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 NM_173864.2_1 - 7.2e-14 52.0 8.6 2.4e-06 27.9 0.6 3.1 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 NM_173864.2_1 - 7e-09 35.7 6.0 3.3e-08 33.6 6.0 2.3 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 NM_173864.2_1 - 9.4e-06 25.6 8.5 4.8e-05 23.3 8.5 2.3 1 0 0 1 1 1 1 Calcium-binding EGF domain CUB_2 PF02408.18 NM_173864.2_1 - 0.00078 19.1 0.6 0.43 10.2 0.1 2.5 2 0 0 2 2 2 2 CUB-like domain Trypsin_2 PF13365.4 NM_173864.2_1 - 0.0026 18.5 0.0 0.0048 17.6 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain EGF PF00008.25 NM_173864.2_1 - 0.081 13.1 8.5 0.41 10.9 8.5 2.3 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.5 NM_173864.2_1 - 0.59 10.8 7.4 0.22 12.1 3.1 2.8 2 0 0 2 2 2 0 Human growth factor-like EGF HRM PF02793.20 NM_173864.2_1 - 1.3 9.2 14.5 0.27 11.4 0.7 3.6 4 0 0 4 4 4 0 Hormone receptor domain C2 PF00168.28 NM_183370.2_3 - 9.8e-34 115.6 0.0 5.6e-18 65.0 0.0 2.4 2 0 0 2 2 2 2 C2 domain DUF3697 PF12478.6 NM_001165983.1_1 - 3e-15 55.9 0.2 7e-15 54.7 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin-associated protein 2 UBA_4 PF14555.4 NM_001165983.1_1 - 0.00037 20.1 0.0 0.00069 19.3 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain Comm PF15957.3 NM_001165983.1_1 - 0.027 14.7 0.2 0.14 12.4 0.2 2.2 1 0 0 1 1 1 0 Commissureless DUF1296 PF06972.9 NM_001165983.1_1 - 0.027 14.5 0.1 0.056 13.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) CUE PF02845.14 NM_001165983.1_1 - 0.29 10.8 2.1 0.38 10.4 0.2 2.1 2 0 0 2 2 2 0 CUE domain Hydrolase PF00702.24 NM_010165.3_3 - 1.3e-06 28.7 0.0 1.7e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Trypsin_2 PF13365.4 NM_001272090.1_1 - 1.1e-10 42.4 4.3 2.5e-06 28.3 0.2 2.7 3 0 0 3 3 3 2 Trypsin-like peptidase domain Trypsin PF00089.24 NM_001272090.1_1 - 0.086 12.5 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Trypsin Trypsin_2 PF13365.4 NM_001272090.1_2 - 4.5e-07 30.7 1.2 7.8e-07 29.9 1.2 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Nucleoplasmin PF03066.13 NM_181345.3_3 - 4.6e-34 116.8 0.0 9.7e-34 115.8 0.0 1.6 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain Mif2_N PF15624.4 NM_181345.3_3 - 0.015 15.8 2.5 0.028 15.0 2.5 1.4 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal CENP-B_dimeris PF09026.8 NM_181345.3_3 - 0.033 14.4 9.2 0.055 13.7 9.2 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain YL1 PF05764.11 NM_181345.3_3 - 5.8 6.9 17.2 6.5 6.7 16.8 1.3 1 1 0 1 1 1 0 YL1 nuclear protein Keratin_matx PF04579.10 NM_023511.1_3 - 1.8e-48 162.7 42.0 2.7e-48 162.1 42.0 1.3 1 0 0 1 1 1 1 Keratin, high-sulphur matrix protein Bim_N PF06773.9 NM_207681.2_1 - 6.6e-21 73.6 8.0 1.7e-20 72.3 8.0 1.8 1 0 0 1 1 1 1 Bim protein N-terminus Bclx_interact PF08945.8 NM_207681.2_1 - 4.8e-19 67.7 3.2 1e-18 66.7 3.2 1.5 1 0 0 1 1 1 1 Bcl-x interacting, BH3 domain LRR_8 PF13855.4 NM_001290756.1_3 - 1.1e-69 229.9 102.7 9.3e-12 44.4 3.2 14.6 11 3 3 14 14 14 13 Leucine rich repeat LRR_4 PF12799.5 NM_001290756.1_3 - 1.1e-35 120.7 98.0 6.5e-06 26.2 1.7 16.2 10 5 7 18 18 18 12 Leucine Rich repeats (2 copies) TIR PF01582.18 NM_001290756.1_3 - 2.7e-14 53.2 0.6 4.7e-14 52.4 0.6 1.4 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.4 NM_001290756.1_3 - 2.2e-11 43.7 15.2 0.0013 18.6 0.2 6.9 4 2 3 7 7 7 3 Leucine rich repeats (6 copies) LRR_1 PF00560.31 NM_001290756.1_3 - 4.7e-10 38.3 82.0 0.16 12.4 0.1 21.4 20 6 2 22 22 22 6 Leucine Rich Repeat LRR_9 PF14580.4 NM_001290756.1_3 - 2.2e-09 36.9 43.2 0.0017 17.7 4.4 7.3 4 3 2 6 6 6 5 Leucine-rich repeat LRR_6 PF13516.4 NM_001290756.1_3 - 9.5e-06 25.1 64.4 0.46 10.5 0.3 16.7 17 0 0 17 17 17 4 Leucine Rich repeat TIR_2 PF13676.4 NM_001290756.1_3 - 0.00057 20.0 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 TIR domain LRRNT PF01462.16 NM_001290756.1_3 - 0.068 12.7 2.3 1.1 8.8 0.0 4.1 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain FYVE_2 PF02318.14 NM_176846.3_1 - 0.0032 17.5 0.7 0.0077 16.3 0.7 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger V-set PF07686.15 NM_001161356.1_2 - 4.8e-09 36.2 0.0 9.5e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 NM_001161356.1_2 - 0.022 14.8 0.1 0.11 12.5 0.1 2.0 1 1 0 1 1 1 0 Immunoglobulin domain I-set PF07679.14 NM_001161356.1_2 - 0.077 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain Serpin PF00079.18 NM_001310472.1_1 - 7.7e-74 249.1 0.0 9.8e-74 248.7 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) 7tm_1 PF00001.19 NM_001304955.1_3 - 2.6e-58 197.2 28.0 2.6e-58 197.2 28.0 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001304955.1_3 - 1.4e-08 34.4 26.6 1.8e-08 34.0 26.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_001304955.1_3 - 4.5e-05 22.8 27.8 4.5e-05 22.8 27.8 1.5 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Guanylate_cyc PF00211.18 NM_001037723.3_2 - 1.5e-119 396.1 0.0 5.3e-62 208.6 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.12 NM_001037723.3_2 - 1e-32 112.6 0.0 1.8e-32 111.9 0.0 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) AC_N PF16214.3 NM_001037723.3_2 - 1.3e-16 60.7 11.0 1.3e-16 60.7 11.0 2.0 3 0 0 3 3 3 1 Adenylyl cyclase N-terminal extracellular and transmembrane region ubiquitin PF00240.21 NM_016694.4_2 - 1.2e-19 69.6 0.0 1.9e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family IBR PF01485.19 NM_016694.4_2 - 6.8e-13 48.5 23.9 6.4e-09 35.8 1.4 4.8 4 1 0 4 4 4 2 IBR domain, a half RING-finger domain Rad60-SLD PF11976.6 NM_016694.4_2 - 4.4e-07 29.5 0.0 6.4e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.4 NM_016694.4_2 - 0.046 13.7 0.0 0.087 12.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 NM_016694.4_2 - 0.055 13.9 0.0 0.096 13.1 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain BING4CT PF08149.9 NM_020603.2_1 - 3.3e-36 122.8 0.0 1.3e-32 111.3 0.0 3.6 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.30 NM_020603.2_1 - 3.5e-05 24.4 3.7 0.019 15.7 0.0 4.7 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_020603.2_1 - 0.0028 17.8 0.0 19 5.5 0.0 4.4 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain AP3D1 PF06375.9 NM_020603.2_2 - 4.8 7.3 17.4 0.02 15.0 8.5 1.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Methyltransf_25 PF13649.4 NM_001252477.1_1 - 1.3e-06 28.9 0.1 3.5e-06 27.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.11 NM_001252477.1_1 - 2.4e-06 27.0 0.1 3.7e-06 26.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.4 NM_001252477.1_1 - 6.6e-06 26.0 0.0 3.8e-05 23.5 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.10 NM_001252477.1_1 - 5e-05 23.7 0.1 0.00015 22.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.4 NM_001252477.1_1 - 0.00032 20.4 0.1 0.00051 19.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 NM_001252477.1_1 - 0.00059 19.3 0.0 0.00093 18.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain DOT1 PF08123.11 NM_001252477.1_1 - 0.0014 18.1 0.4 0.0039 16.6 0.1 1.8 1 1 1 2 2 2 1 Histone methylation protein DOT1 Met_10 PF02475.14 NM_001252477.1_1 - 0.0017 18.0 0.1 0.0023 17.6 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_9 PF08003.9 NM_001252477.1_1 - 0.0042 15.9 0.0 0.0066 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.18 NM_001252477.1_1 - 0.0076 15.4 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.17 NM_001252477.1_1 - 0.012 15.2 0.1 0.022 14.4 0.1 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.7 NM_001252477.1_1 - 0.077 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase DUF3508 PF12018.6 NM_027041.4_3 - 7.5e-105 350.2 5.8 1.2e-104 349.6 5.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3508) SRP-alpha_N PF04086.11 NM_183321.1_2 - 3.3 7.4 32.0 4.6 6.9 32.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Vfa1 PF08432.8 NM_183321.1_2 - 5.8 7.1 36.5 8.6 6.5 36.5 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 GNT-I PF03071.13 NM_026651.2_1 - 3.2e-48 164.5 0.0 5.2e-48 163.7 0.0 1.2 1 0 0 1 1 1 1 GNT-I family ILEI PF15711.3 NM_026651.2_1 - 3.1e-25 88.3 0.0 5.8e-25 87.5 0.0 1.5 1 0 0 1 1 1 1 Interleukin-like EMT inducer Peptidase_M1 PF01433.18 NM_001289924.1_2 - 4.2e-24 85.4 0.0 9.6e-13 48.0 0.0 2.5 3 0 0 3 3 3 2 Peptidase family M1 Leuk-A4-hydro_C PF09127.9 NM_001289924.1_2 - 1.1e-23 83.7 1.7 2.1e-23 82.8 1.1 1.8 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal Radical_SAM PF04055.19 NM_025966.3_2 - 0.013 15.8 0.0 0.017 15.4 0.0 1.1 1 0 0 1 1 1 0 Radical SAM superfamily zf-C2H2 PF00096.24 NM_010636.3_3 - 7.8e-14 51.1 23.1 3.3e-05 24.0 2.9 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_010636.3_3 - 1.8e-10 40.6 20.8 1.1e-06 28.7 1.5 4.6 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_010636.3_3 - 0.05 14.3 28.8 0.33 11.8 1.9 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-met PF12874.5 NM_010636.3_3 - 0.11 12.7 5.9 2.3 8.6 0.4 3.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type FH2 PF02181.21 NM_019445.2_3 - 1.6e-99 333.4 10.7 1.6e-99 333.4 10.7 1.6 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH1 PF06346.10 NM_019445.2_3 - 5.3e-18 65.0 327.5 5.7e-11 42.2 107.3 7.4 4 1 4 8 8 8 4 Formin Homology Region 1 IFN-gamma PF00714.15 NM_019445.2_3 - 0.023 14.4 0.1 0.072 12.8 0.1 1.8 1 1 0 1 1 1 0 Interferon gamma DEP PF00610.19 NM_019445.2_3 - 0.085 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DnaJ_C PF01556.16 NM_001308227.1_3 - 1e-41 142.3 0.1 1.3e-41 142.0 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain UPF0515 PF15135.4 NM_175687.2_2 - 1.3e-123 411.4 3.6 1.6e-123 411.1 3.6 1.1 1 0 0 1 1 1 1 Uncharacterised protein UPF0515 zf-3CxxC_2 PF17180.2 NM_175687.2_2 - 0.00084 19.9 10.7 0.045 14.3 0.7 2.7 1 1 1 2 2 2 2 Zinc-binding domain DUF3915 PF13054.4 NM_175687.2_2 - 0.0025 17.6 2.7 0.0084 16.0 2.7 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 NM_175687.2_2 - 0.0097 14.1 11.2 0.012 13.8 9.0 1.9 2 0 0 2 2 2 1 Atrophin-1 family Zn-ribbon_8 PF09723.8 NM_175687.2_2 - 0.045 13.8 10.4 0.24 11.4 1.9 2.8 2 1 1 3 3 3 0 Zinc ribbon domain zf-RING_4 PF14570.4 NM_175687.2_2 - 0.16 11.6 4.4 7.5 6.2 0.0 2.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zinc_ribbon_4 PF13717.4 NM_175687.2_2 - 0.25 11.1 13.2 0.76 9.6 0.1 3.4 2 1 1 3 3 3 0 zinc-ribbon domain zinc-ribbons_6 PF07191.10 NM_175687.2_2 - 1.3 8.9 5.4 5 7.1 4.2 2.2 1 1 1 2 2 2 0 zinc-ribbons FAM27 PF15832.3 NM_175687.2_2 - 1.6 9.2 7.4 0.54 10.7 3.3 2.3 2 0 0 2 2 2 0 FAM27 D and E protein family HypA PF01155.17 NM_175687.2_2 - 7.6 6.5 6.1 7.4 6.5 3.7 2.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3915 PF13054.4 NM_175687.2_3 - 0.0074 16.1 8.2 0.019 14.8 8.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) LRR_4 PF12799.5 NM_001309233.1_1 - 3.2e-16 59.0 28.1 0.003 17.8 0.1 8.5 4 1 3 9 9 9 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 NM_001309233.1_1 - 3.7e-13 48.3 32.7 0.07 13.1 0.1 12.8 13 0 0 13 13 13 6 Leucine Rich repeat LRR_1 PF00560.31 NM_001309233.1_1 - 2.9e-11 42.0 29.9 7.1 7.4 0.7 12.7 13 0 0 13 13 13 1 Leucine Rich Repeat LRR_8 PF13855.4 NM_001309233.1_1 - 2.1e-06 27.2 31.3 0.041 13.5 0.6 9.0 4 1 4 9 9 9 6 Leucine rich repeat DNA_pol_B_thumb PF14791.4 NM_001309233.1_1 - 0.15 12.1 0.0 0.43 10.6 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase beta thumb ANAPC5 PF12862.5 NM_001289518.1_1 - 4e-31 106.8 11.8 8.3e-31 105.8 1.2 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 5 TPR_12 PF13424.4 NM_001289518.1_1 - 6.3e-10 39.1 14.2 1.6e-05 24.9 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.4 NM_001289518.1_1 - 9.7e-05 22.0 9.2 0.025 14.3 2.2 3.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.15 NM_001289518.1_1 - 0.032 14.2 16.3 0.9 9.7 2.2 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.4 NM_001289518.1_1 - 0.048 13.6 8.0 0.11 12.4 0.7 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001289518.1_1 - 0.12 12.1 8.6 2.7 7.8 1.3 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001289518.1_1 - 3.3 8.1 18.2 12 6.4 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.4 NM_001289518.1_1 - 8 7.0 8.3 1.1e+02 3.3 0.4 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat RIIa PF02197.15 NM_001033345.2_3 - 0.027 14.0 0.4 0.051 13.1 0.4 1.4 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit DUF809 PF05663.9 NM_001033345.2_3 - 0.097 12.7 9.9 0.18 11.8 9.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF809) DUF1682 PF07946.12 NM_001033345.2_3 - 4.2 6.4 5.7 6.3 5.8 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Tmemb_cc2 PF10267.7 NM_001126488.2_2 - 2.9e-67 227.4 20.7 4.4e-42 144.5 11.7 2.0 1 1 1 2 2 2 2 Predicted transmembrane and coiled-coil 2 protein DUF2207 PF09972.7 NM_001126488.2_2 - 0.089 11.4 0.2 0.16 10.6 0.2 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Ino80_Iec3 PF14612.4 NM_001126488.2_2 - 0.23 12.0 11.1 0.036 14.6 5.7 2.0 2 1 1 3 3 3 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling CP12 PF02672.13 NM_001126488.2_2 - 0.66 10.7 4.9 2 9.1 0.8 3.1 3 0 0 3 3 3 0 CP12 domain DUF3915 PF13054.4 NM_001033366.3_1 - 0.11 12.4 9.0 0.2 11.5 9.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 NM_001033366.3_2 - 0.00024 20.9 5.7 0.00045 20.0 5.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) DUF3915 PF13054.4 NM_001033366.3_3 - 0.094 12.6 9.8 0.19 11.6 9.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) MORN PF02493.18 NM_021566.2_1 - 8.6e-33 110.2 62.8 2.5e-06 26.9 0.2 8.9 8 0 0 8 8 8 8 MORN repeat p450 PF00067.20 NM_023623.2_1 - 8.2e-96 321.4 0.5 6.7e-93 311.8 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 WD40 PF00400.30 NM_001163766.1_2 - 3e-34 116.3 47.6 0.00019 22.0 0.2 19.4 20 1 1 21 21 21 9 WD domain, G-beta repeat DUF667 PF05018.11 NM_001163766.1_2 - 1.4e-31 109.5 0.0 7.1e-23 81.1 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF667) ANAPC4_WD40 PF12894.5 NM_001163766.1_2 - 6.4e-19 67.9 0.0 0.088 13.0 0.0 10.6 8 4 3 11 11 11 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_001163766.1_2 - 1.3e-06 27.3 1.0 0.00032 19.3 0.0 4.2 4 1 1 5 5 5 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 NM_001163766.1_2 - 0.0004 19.3 0.4 6.4 5.5 0.0 4.6 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein HELP PF03451.12 NM_001163766.1_2 - 0.014 15.1 0.0 1.5 8.6 0.0 2.6 2 0 0 2 2 2 0 HELP motif Ribosomal_L22e PF01776.15 NM_026517.2_1 - 1.3e-48 163.7 2.4 1.7e-48 163.4 2.4 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family RasGEF PF00617.17 NM_029004.1_2 - 4e-52 176.7 0.2 6.1e-52 176.1 0.2 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 NM_029004.1_2 - 3.2e-12 46.5 0.0 6.3e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 RasGEF N-terminal motif PDZ PF00595.22 NM_001013580.3_2 - 1.3e-37 127.8 6.3 4.4e-16 58.9 0.2 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_001013580.3_2 - 2.5e-14 53.2 0.3 8.7e-06 25.8 0.1 3.7 3 1 1 4 4 4 3 PDZ domain PHD PF00628.27 NM_027927.4_3 - 1.3e-09 37.7 9.9 2.5e-09 36.8 9.9 1.5 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.20 NM_027927.4_3 - 9.7e-05 22.1 3.0 9.7e-05 22.1 3.0 2.0 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.4 NM_027927.4_3 - 0.00043 19.8 2.7 0.00069 19.1 2.7 1.3 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain PHD_4 PF16866.3 NM_027927.4_3 - 0.0037 17.2 6.2 0.0086 16.0 6.2 1.6 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.4 NM_027927.4_3 - 0.0045 16.8 3.8 0.01 15.6 3.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 PHD_2 PF13831.4 NM_027927.4_3 - 0.005 16.2 5.4 0.014 14.7 5.4 1.9 1 0 0 1 1 1 1 PHD-finger zf-4CXXC_R1 PF10497.7 NM_027927.4_3 - 0.14 12.3 5.5 0.27 11.4 5.5 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Peptidase_S24 PF00717.21 NM_025468.2_3 - 4.8e-11 42.3 0.2 7.7e-11 41.7 0.2 1.3 1 0 0 1 1 1 1 Peptidase S24-like Mito_carr PF00153.25 NM_133668.3_2 - 2.9e-48 161.6 7.0 3.2e-19 68.5 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein EGF_CA PF07645.13 NM_001310678.1_3 - 2.5e-120 392.4 206.9 2.6e-10 40.2 2.1 16.7 17 0 0 17 17 17 15 Calcium-binding EGF domain cEGF PF12662.5 NM_001310678.1_3 - 1.7e-83 273.9 123.4 2.8e-09 36.6 1.9 17.0 17 0 0 17 17 17 15 Complement Clr-like EGF-like EGF_3 PF12947.5 NM_001310678.1_3 - 1.4e-21 76.2 172.0 7.7e-05 22.7 6.6 17.3 14 2 2 17 17 17 11 EGF domain FXa_inhibition PF14670.4 NM_001310678.1_3 - 1.2e-18 66.9 247.5 5.8e-05 23.2 7.0 18.6 15 3 3 19 19 19 14 Coagulation Factor Xa inhibitory site EGF PF00008.25 NM_001310678.1_3 - 2.2e-17 62.9 247.3 0.0025 17.9 5.7 18.8 18 1 0 18 18 18 12 EGF-like domain hEGF PF12661.5 NM_001310678.1_3 - 4.5e-17 61.9 239.5 0.0034 17.9 6.2 21.9 23 2 0 23 23 23 13 Human growth factor-like EGF TB PF00683.15 NM_001310678.1_3 - 2.3e-16 59.1 20.5 2e-12 46.5 4.1 4.6 3 0 0 3 3 3 2 TB domain EGF_2 PF07974.11 NM_001310678.1_3 - 0.00039 20.6 4.2 0.00039 20.6 4.2 17.3 16 1 1 17 17 17 8 EGF-like domain Plasmod_Pvs28 PF06247.9 NM_001310678.1_3 - 0.00093 19.3 114.3 0.024 14.8 2.5 14.4 14 0 0 14 14 14 6 Pvs28 EGF domain Trypan_PARP PF05887.9 NM_001310678.1_3 - 0.58 10.0 42.0 0.015 15.2 34.7 2.2 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Trypsin PF00089.24 NM_008198.2_1 - 1.6e-44 152.2 0.1 2.7e-44 151.5 0.1 1.4 1 0 0 1 1 1 1 Trypsin VWA PF00092.26 NM_008198.2_1 - 8.4e-36 123.7 0.0 1.3e-35 123.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Sushi PF00084.18 NM_008198.2_1 - 5.5e-26 90.8 15.6 1.1e-12 48.2 1.7 4.1 4 0 0 4 4 4 3 Sushi repeat (SCR repeat) VWA_2 PF13519.4 NM_008198.2_1 - 5.4e-11 43.0 0.0 1.9e-10 41.2 0.0 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain HRM PF02793.20 NM_008198.2_1 - 2.8e-05 24.2 8.5 0.66 10.2 0.7 3.5 2 1 1 3 3 3 3 Hormone receptor domain DUF1986 PF09342.9 NM_008198.2_1 - 0.00012 22.3 0.0 0.00022 21.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 NM_008198.2_1 - 0.014 16.2 0.0 0.04 14.7 0.0 1.8 1 1 0 1 1 1 0 Trypsin-like peptidase domain V-set PF07686.15 NM_007543.4_1 - 1.8e-15 56.9 0.1 5.3e-09 36.1 0.0 3.4 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_007543.4_1 - 6.3e-15 55.4 0.2 9.3e-10 38.9 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_007543.4_1 - 6.7e-14 51.7 7.1 4.9e-12 45.7 0.1 2.8 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 NM_007543.4_1 - 5.5e-11 42.3 0.3 4.2e-07 29.8 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_007543.4_1 - 4e-07 30.1 0.1 4e-07 30.1 0.1 2.6 3 0 0 3 3 3 1 Immunoglobulin domain Izumo-Ig PF16706.3 NM_007543.4_1 - 0.0012 18.7 0.1 2.4 8.1 0.0 2.4 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 NM_007543.4_1 - 0.0019 18.3 0.1 0.13 12.4 0.0 2.4 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 AA_permease_2 PF13520.4 NM_011990.2_2 - 1e-57 195.8 37.8 1.9e-57 194.9 37.8 1.4 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 NM_011990.2_2 - 5.4e-31 107.6 33.9 9.7e-31 106.7 33.9 1.3 1 0 0 1 1 1 1 Amino acid permease zf-C2H2 PF00096.24 NM_173429.2_2 - 4e-48 159.1 113.4 1.2e-05 25.4 2.6 12.6 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_173429.2_2 - 3.6e-44 147.2 86.5 8.9e-08 32.1 4.0 13.4 13 0 0 13 13 13 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_173429.2_2 - 1.9e-28 96.5 95.4 0.0017 18.9 1.5 12.3 11 0 0 11 11 11 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_173429.2_2 - 1.3e-10 41.0 40.4 0.004 17.1 1.5 7.5 5 2 0 6 6 6 4 Zinc ribbon domain MBD PF01429.17 NM_173429.2_2 - 6.8e-06 25.6 1.1 0.14 11.8 0.0 4.6 3 2 1 4 4 4 1 Methyl-CpG binding domain zf-C2H2_11 PF16622.3 NM_173429.2_2 - 1.7e-05 24.3 3.9 0.0016 18.0 0.3 11.6 12 0 0 12 12 12 4 zinc-finger C2H2-type DUF3268 PF11672.6 NM_173429.2_2 - 0.0034 17.6 27.0 0.18 12.1 0.3 5.4 4 2 1 6 6 6 3 zinc-finger-containing domain zf-C2H2_6 PF13912.4 NM_173429.2_2 - 0.016 15.1 87.8 0.034 14.0 3.9 12.0 12 0 0 12 12 12 0 C2H2-type zinc finger HypA PF01155.17 NM_173429.2_2 - 0.28 11.1 33.9 0.48 10.3 1.2 5.8 4 2 1 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA KTI12 PF08433.8 NM_001039534.1_2 - 9.5e-22 77.6 0.1 2.1e-15 56.8 0.3 2.1 2 0 0 2 2 2 2 Chromatin associated protein KTI12 AAA_33 PF13671.4 NM_001039534.1_2 - 1.7e-10 41.1 0.0 1.5e-08 34.8 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.4 NM_001039534.1_2 - 1.1e-05 25.8 0.0 0.015 15.7 0.0 2.7 3 0 0 3 3 3 2 AAA domain APS_kinase PF01583.18 NM_001039534.1_2 - 0.00056 19.7 0.0 0.49 10.1 0.0 2.5 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_16 PF13191.4 NM_001039534.1_2 - 0.00069 19.9 0.1 0.0027 18.0 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain ArgK PF03308.14 NM_001039534.1_2 - 0.012 14.5 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 ArgK protein AAA_22 PF13401.4 NM_001039534.1_2 - 0.019 15.1 0.0 0.12 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.4 NM_001039534.1_2 - 0.04 13.4 0.0 0.094 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain DEAD_assoc PF08494.9 NM_001039534.1_2 - 0.067 12.9 0.1 2.1 8.0 0.0 2.2 2 0 0 2 2 2 0 DEAD/H associated ParA PF10609.7 NM_001039534.1_2 - 0.077 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase Zeta_toxin PF06414.10 NM_001039534.1_2 - 0.1 11.7 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.21 NM_001039534.1_2 - 0.17 11.8 0.0 0.69 9.9 0.0 2.2 2 1 0 2 2 2 0 50S ribosome-binding GTPase LMBR1 PF04791.14 NM_001039534.1_2 - 0.79 8.4 2.8 0.95 8.2 2.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein RGS PF00615.17 NM_001291207.1_1 - 4.7e-34 117.1 0.1 6.2e-34 116.7 0.1 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Cyclin_N PF00134.21 NM_001122982.2_1 - 1.2e-13 50.9 3.3 2.3e-12 46.7 0.8 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.3 NM_001122982.2_1 - 1.1e-06 28.8 0.2 3.2e-06 27.3 0.2 1.8 1 1 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.17 NM_001122982.2_1 - 0.026 14.4 0.2 0.23 11.4 0.0 2.2 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Cyclin_C PF02984.17 NM_001122982.2_1 - 0.061 13.3 0.1 0.43 10.5 0.0 2.3 2 1 1 3 3 3 0 Cyclin, C-terminal domain 7tm_4 PF13853.4 NM_146784.1_1 - 3.5e-45 154.8 25.8 4.4e-45 154.4 25.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146784.1_1 - 1.9e-22 79.7 28.2 2.8e-22 79.1 28.2 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146784.1_1 - 0.00023 20.5 29.2 0.00033 20.0 29.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Ank_2 PF12796.5 NM_026853.2_1 - 3.6e-28 97.8 5.7 2.5e-11 43.9 3.0 4.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_026853.2_1 - 6.5e-25 84.4 6.6 0.0069 16.7 0.0 6.7 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.4 NM_026853.2_1 - 4.5e-24 84.0 10.6 3.3e-07 30.4 0.1 5.9 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_026853.2_1 - 2.8e-23 81.8 12.0 7.5e-09 35.8 0.2 5.5 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 NM_026853.2_1 - 2.9e-20 71.6 11.5 0.00017 21.8 0.2 7.2 7 0 0 7 7 7 5 Ankyrin repeat SOCS_box PF07525.14 NM_026853.2_1 - 1.4e-08 34.8 2.9 3.7e-08 33.5 2.9 1.7 1 0 0 1 1 1 1 SOCS box DUF4787 PF16029.3 NM_026853.2_1 - 0.088 12.8 0.4 0.31 11.0 0.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4787) Yae1_N PF09811.7 NM_025904.3_1 - 1.5e-11 43.7 1.2 2.2e-11 43.1 1.2 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Alk_phosphatase PF00245.18 NM_001287172.1_2 - 8.5e-180 598.0 1.1 1.1e-179 597.6 1.1 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.16 NM_001287172.1_2 - 0.00078 18.7 0.2 0.0016 17.7 0.2 1.6 1 1 0 1 1 1 1 Metalloenzyme superfamily Forkhead PF00250.16 NM_008022.2_2 - 4.7e-36 122.8 0.0 8.9e-36 121.9 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain Peptidase_S8 PF00082.20 NM_001167910.1_2 - 3.1e-39 134.9 0.0 4.5e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Subtilase family DUF4350 PF14258.4 NM_001167910.1_2 - 0.084 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) Linker_histone PF00538.17 NM_001285479.1_1 - 5.1e-50 167.6 0.3 5.1e-17 61.9 0.1 3.4 3 0 0 3 3 3 3 linker histone H1 and H5 family SDA1 PF05285.10 NM_001285479.1_1 - 0.027 13.8 22.7 0.36 10.1 13.7 2.1 2 0 0 2 2 2 0 SDA1 YL1 PF05764.11 NM_001285479.1_1 - 0.096 12.7 27.7 0.045 13.8 9.5 2.2 2 0 0 2 2 2 0 YL1 nuclear protein Cadherin PF00028.15 NM_053141.3_3 - 2.9e-77 255.1 0.0 2.4e-18 66.2 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_053141.3_3 - 1.8e-34 117.3 2.1 6.4e-32 109.1 0.6 3.6 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 NM_053141.3_3 - 1.3e-27 96.3 0.1 3.6e-27 94.8 0.1 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 NM_053141.3_3 - 0.00063 19.6 0.8 0.036 13.9 0.1 3.6 4 0 0 4 4 4 1 Cadherin-like DUF4958 PF16319.3 NM_053141.3_3 - 0.016 13.2 0.0 0.026 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4958) Cystatin PF00031.19 NM_001083905.1_1 - 1.5e-21 76.3 0.0 3.6e-12 46.3 0.0 2.2 2 0 0 2 2 2 2 Cystatin domain Cathelicidins PF00666.15 NM_001083905.1_1 - 0.017 15.3 0.1 3.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Cathelicidin zf-Sec23_Sec24 PF04810.13 NM_001083905.1_2 - 0.03 14.2 0.4 0.079 12.9 0.4 1.8 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Takusan PF04822.11 NM_173069.3_1 - 5.8e-26 90.1 9.4 5.8e-26 90.1 9.4 1.8 2 0 0 2 2 2 1 Takusan Mo-nitro_C PF06967.9 NM_173069.3_1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Mo-dependent nitrogenase C-terminus TcdB_N PF12918.5 NM_173069.3_1 - 0.19 11.9 4.8 0.092 12.9 1.8 2.0 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain Roughex PF06020.9 NM_173069.3_1 - 2.6 6.9 9.2 0.09 11.7 3.4 1.5 2 0 0 2 2 2 0 Drosophila roughex protein Ldl_recept_b PF00058.15 NM_008514.4_1 - 1.8e-147 479.4 41.8 2.1e-12 47.2 0.2 20.9 21 0 0 21 21 21 20 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 NM_008514.4_1 - 2.6e-41 139.4 53.3 6.9e-12 45.3 4.9 5.4 5 0 0 5 5 5 4 Coagulation Factor Xa inhibitory site Ldl_recept_a PF00057.16 NM_008514.4_1 - 7.7e-29 99.5 49.8 2.2e-10 40.4 12.1 4.1 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A DUF5050 PF16472.3 NM_008514.4_1 - 2.4e-18 66.3 0.0 2.1e-05 23.8 0.0 5.8 4 2 2 6 6 6 5 Domain of unknown function (DUF5050) SGL PF08450.10 NM_008514.4_1 - 8.1e-15 54.9 21.6 0.0054 16.2 0.0 10.7 4 4 3 9 9 9 6 SMP-30/Gluconolaconase/LRE-like region EGF PF00008.25 NM_008514.4_1 - 0.00054 20.1 53.8 0.032 14.4 3.5 6.2 5 0 0 5 5 5 4 EGF-like domain cEGF PF12662.5 NM_008514.4_1 - 0.00068 19.4 19.6 0.029 14.2 0.7 4.8 4 0 0 4 4 4 3 Complement Clr-like EGF-like NHL PF01436.19 NM_008514.4_1 - 0.068 13.1 0.2 53 4.0 0.0 4.8 3 0 0 3 3 3 0 NHL repeat DUF1041 PF06292.15 NM_001252110.1_3 - 1.2e-32 112.2 2.4 3e-32 111.0 2.4 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) PH PF00169.27 NM_001252110.1_3 - 4.7e-09 36.6 0.0 9.8e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 PH domain WD40 PF00400.30 NM_030732.3_2 - 6.1e-47 156.5 24.9 2.2e-09 37.6 0.2 9.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_030732.3_2 - 8.5e-25 86.8 1.3 3.5e-07 30.3 0.1 5.8 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.9 NM_030732.3_2 - 6e-09 35.4 0.1 2.5e-08 33.5 0.1 2.2 1 0 0 1 1 1 1 LisH eIF2A PF08662.9 NM_030732.3_2 - 1.1e-08 35.1 0.7 0.0024 17.7 0.1 2.9 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.12 NM_030732.3_2 - 0.0032 16.5 0.0 0.031 13.2 0.0 2.0 2 0 0 2 2 2 1 Coatomer WD associated region WD40_like PF17005.3 NM_030732.3_2 - 0.019 14.2 0.0 2.9 7.0 0.0 2.3 2 0 0 2 2 2 0 WD40-like domain PH_13 PF16652.3 NM_010587.2_1 - 7.1e-73 243.5 0.1 7.1e-73 243.5 0.1 2.4 3 0 0 3 3 1 1 Pleckstrin homology domain SH3_9 PF14604.4 NM_010587.2_1 - 2e-65 216.3 8.6 9.9e-16 57.2 0.1 5.7 5 0 0 5 5 5 5 Variant SH3 domain SH3_1 PF00018.26 NM_010587.2_1 - 3.7e-60 199.2 13.7 1.1e-15 56.8 0.2 5.5 5 0 0 5 5 5 5 SH3 domain SH3_2 PF07653.15 NM_010587.2_1 - 7.4e-54 179.1 2.6 5.4e-13 48.3 0.0 5.6 5 0 0 5 5 5 5 Variant SH3 domain INTAP PF16617.3 NM_010587.2_1 - 1.2e-52 177.1 12.6 1.2e-52 177.1 12.6 2.8 2 0 0 2 2 1 1 Intersectin and clathrin adaptor AP2 binding region RhoGEF PF00621.18 NM_010587.2_1 - 7.5e-45 153.3 1.5 7.5e-45 153.3 1.5 2.2 2 0 0 2 2 2 1 RhoGEF domain EF-hand_4 PF12763.5 NM_010587.2_1 - 3.9e-29 100.5 0.0 2.5e-14 52.9 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand C2 PF00168.28 NM_010587.2_1 - 8.5e-21 74.0 0.0 2e-20 72.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain EF-hand_1 PF00036.30 NM_010587.2_1 - 9.9e-08 30.9 0.0 0.0066 15.8 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 NM_010587.2_1 - 4.9e-05 22.8 0.0 0.73 9.8 0.0 3.7 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.4 NM_010587.2_1 - 0.0012 19.1 0.0 0.068 13.5 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain pair PH PF00169.27 NM_010587.2_1 - 0.0019 18.5 0.0 0.0047 17.3 0.0 1.6 1 0 0 1 1 1 1 PH domain GSH_synthase PF03199.13 NM_010587.2_1 - 0.067 13.5 0.0 0.25 11.7 0.0 2.0 1 0 0 1 1 1 0 Eukaryotic glutathione synthase EF-hand_5 PF13202.4 NM_010587.2_1 - 0.097 12.1 0.2 1.7 8.2 0.0 2.4 2 0 0 2 2 2 0 EF hand UBZ_FAAP20 PF15750.3 NM_001177360.1_1 - 3.5 7.5 6.4 4.8 7.1 2.0 2.5 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger zf-B_box PF00643.22 NM_001024134.2_3 - 3e-08 33.6 1.2 3e-08 33.6 1.2 4.0 4 1 0 4 4 2 1 B-box zinc finger zf-C3HC4_2 PF13923.4 NM_001024134.2_3 - 4.7e-06 26.2 9.2 1.2e-05 24.9 9.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_001024134.2_3 - 4.8e-06 26.3 5.1 4.8e-06 26.3 5.1 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 NM_001024134.2_3 - 1.1e-05 25.3 8.5 1.1e-05 25.3 8.5 2.8 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 NM_001024134.2_3 - 6.8e-05 22.5 6.4 0.00023 20.9 6.4 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_001024134.2_3 - 0.00014 21.5 6.3 0.00014 21.5 6.3 2.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001024134.2_3 - 0.00043 20.1 7.4 0.002 18.0 7.4 2.3 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 NM_001024134.2_3 - 0.00051 19.7 6.7 0.00051 19.7 6.7 2.1 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 Lipoprotein_7 PF01540.14 NM_001024134.2_3 - 0.045 12.9 1.4 0.064 12.4 1.4 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein Apolipoprotein PF01442.16 NM_001024134.2_3 - 0.046 13.5 13.9 0.091 12.5 13.9 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF2935 PF11155.6 NM_001024134.2_3 - 0.078 13.2 0.1 0.17 12.1 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) CorA PF01544.16 NM_001024134.2_3 - 0.083 12.1 10.5 0.11 11.7 10.2 1.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein AAA_13 PF13166.4 NM_001024134.2_3 - 0.34 9.4 7.8 0.49 8.9 7.8 1.1 1 0 0 1 1 1 0 AAA domain LMBR1 PF04791.14 NM_001024134.2_3 - 0.43 9.3 4.1 0.63 8.7 4.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_32 PF13654.4 NM_001024134.2_3 - 0.48 9.0 9.1 0.72 8.4 9.1 1.2 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.9 NM_001024134.2_3 - 0.49 9.1 13.5 0.83 8.3 13.5 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.6 NM_001024134.2_3 - 0.61 7.4 14.4 0.75 7.1 14.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) COG5 PF10392.7 NM_001024134.2_3 - 0.83 9.7 6.6 2.4 8.2 0.8 2.6 1 1 1 2 2 2 0 Golgi transport complex subunit 5 ABC_tran_CTD PF16326.3 NM_001024134.2_3 - 1.4 9.1 14.5 1.2 9.3 2.7 2.8 2 1 0 2 2 2 0 ABC transporter C-terminal domain Fib_alpha PF08702.8 NM_001024134.2_3 - 2.6 8.1 15.6 1.2 9.2 12.7 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF745 PF05335.11 NM_001024134.2_3 - 3 7.4 7.9 0.78 9.3 4.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF745) LPP PF04728.11 NM_001024134.2_3 - 3.5 7.9 5.3 0.76 10.1 0.4 2.2 2 0 0 2 2 2 0 Lipoprotein leucine-zipper 7tm_3 PF00003.20 NM_009489.2_2 - 2.4e-58 197.5 24.9 2.4e-58 197.5 24.9 1.8 3 0 0 3 3 3 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_009489.2_2 - 1.3e-31 109.8 0.0 2.3e-31 109.1 0.0 1.3 1 1 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_009489.2_2 - 9.6e-14 51.0 6.9 2.3e-13 49.7 6.9 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR ErmC PF06308.9 NM_009489.2_2 - 0.11 12.8 0.2 0.54 10.6 0.2 2.2 1 0 0 1 1 1 0 23S rRNA methylase leader peptide (ErmC) C2-C2_1 PF11618.6 NM_023879.3_1 - 2.4e-56 189.6 0.0 2.7e-49 166.7 0.0 3.8 4 0 0 4 4 4 2 First C2 domain of RPGR-interacting protein 1 C2 PF00168.28 NM_023879.3_1 - 1.6e-05 25.0 0.0 0.00013 22.1 0.0 2.6 2 0 0 2 2 2 1 C2 domain TNFR_c6 PF00020.16 NM_001164155.1_1 - 5.6e-07 29.7 27.5 0.00011 22.4 6.0 3.7 3 0 0 3 3 3 2 TNFR/NGFR cysteine-rich region Reprolysin PF01421.17 NM_001291066.2_2 - 2.9e-71 239.4 0.0 2.9e-71 239.4 0.0 1.8 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 NM_001291066.2_2 - 9.8e-31 106.7 0.2 1.8e-30 105.9 0.2 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 NM_001291066.2_2 - 7.9e-21 75.0 0.0 1.6e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 NM_001291066.2_2 - 2.1e-19 69.9 31.7 2.1e-19 69.9 31.7 3.7 2 1 1 3 3 3 1 Disintegrin Reprolysin_3 PF13582.4 NM_001291066.2_2 - 7.2e-17 61.9 0.7 1.2e-16 61.2 0.7 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 NM_001291066.2_2 - 1.4e-12 47.8 0.0 2.4e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR PF08516.10 NM_001291066.2_2 - 2.2e-09 37.7 5.8 2.2e-09 37.7 5.8 4.3 3 2 0 3 3 3 1 ADAM cysteine-rich Reprolysin_4 PF13583.4 NM_001291066.2_2 - 4.6e-09 36.1 0.7 1.6e-08 34.3 0.7 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 NM_001291066.2_2 - 0.01 15.5 0.1 0.019 14.7 0.1 1.3 1 0 0 1 1 1 0 Matrixin DUF3810 PF12725.5 NM_001291066.2_2 - 0.45 9.7 2.5 2.9 7.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) SMN PF06003.10 NM_001252629.1_2 - 1.1e-104 349.2 8.1 1.6e-104 348.7 8.1 1.2 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.22 NM_001252629.1_2 - 0.0024 17.8 0.1 0.004 17.0 0.1 1.2 1 0 0 1 1 1 1 Tudor domain bZIP_1 PF00170.19 NM_001284376.1_3 - 2.6e-12 46.5 6.5 4.3e-12 45.8 6.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_001284376.1_3 - 2e-08 34.1 6.8 4e-08 33.1 6.8 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001284376.1_3 - 0.02 15.3 6.6 0.038 14.4 6.6 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor ATG16 PF08614.9 NM_001284376.1_3 - 0.75 9.8 9.7 1.5 8.8 9.7 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) ArfGap PF01412.16 NM_139153.2_1 - 7.1e-37 125.9 0.0 1.4e-36 125.0 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ras PF00071.20 NM_139153.2_1 - 1.1e-16 60.7 0.0 1.8e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Ras family PH PF00169.27 NM_139153.2_1 - 3.4e-11 43.4 0.0 0.00041 20.7 0.0 2.8 2 0 0 2 2 2 2 PH domain Ank_2 PF12796.5 NM_139153.2_1 - 8.5e-07 29.3 0.0 1.7e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 NM_139153.2_1 - 2.9e-05 24.4 0.0 0.021 15.3 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 NM_139153.2_1 - 4.4e-05 23.6 0.0 0.11 12.8 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 NM_139153.2_1 - 0.00097 19.3 0.2 0.023 15.0 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) PH_6 PF15406.4 NM_139153.2_1 - 0.0098 16.0 0.1 0.019 15.1 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Roc PF08477.11 NM_139153.2_1 - 0.012 15.7 0.0 0.031 14.4 0.0 1.7 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase HlyIII PF03006.18 NM_175217.6_2 - 2.5e-17 63.2 19.9 3.5e-17 62.7 19.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related RRM_1 PF00076.20 NM_172592.2_3 - 7.3e-13 48.0 0.1 1.2e-12 47.3 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mem_trans PF03547.16 NM_172592.2_3 - 0.015 13.6 0.1 0.015 13.6 0.1 2.2 2 0 0 2 2 2 0 Membrane transport protein RRM_5 PF13893.4 NM_172592.2_3 - 0.016 14.7 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TRAP-gamma PF07074.10 NM_026155.3_2 - 1.8e-82 274.8 7.8 2.5e-82 274.4 7.8 1.2 1 0 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) TFIIF_alpha PF05793.10 NM_133801.2_1 - 4.9e-197 655.6 48.1 5.8e-197 655.3 48.1 1.0 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PH PF00169.27 NM_001163182.1_3 - 7.8e-08 32.6 0.0 1.2e-07 32.1 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_001163182.1_3 - 4.1e-05 23.8 0.2 9e-05 22.7 0.2 1.5 1 1 0 1 1 1 1 Pleckstrin homology domain TRAPPC9-Trs120 PF08626.9 NM_001164641.1_2 - 5.2e-43 146.6 0.0 1.5e-18 65.6 0.0 4.8 2 1 1 4 4 4 4 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Vps23_core PF09454.8 NM_001164641.1_2 - 0.056 13.3 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Vps23 core domain RIC3 PF15361.4 NM_001037913.2_1 - 8.2e-06 26.1 2.5 1.5e-05 25.2 2.5 1.6 1 1 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 IncA PF04156.12 NM_001037913.2_1 - 1e-05 25.3 3.5 1e-05 25.3 3.5 1.5 2 0 0 2 2 2 1 IncA protein RskA PF10099.7 NM_001037913.2_1 - 0.00041 20.6 0.5 0.00062 20.0 0.5 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF948 PF06103.9 NM_001037913.2_1 - 0.0031 17.6 1.2 0.006 16.7 1.2 1.4 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) Med30 PF11315.6 NM_001037913.2_1 - 0.005 17.0 3.1 3.6 7.7 3.0 2.1 1 1 1 2 2 2 2 Mediator complex subunit 30 GAS PF13851.4 NM_001037913.2_1 - 0.0079 15.5 4.8 0.011 14.9 4.8 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF1043 PF06295.10 NM_001037913.2_1 - 0.02 14.7 2.4 0.035 14.0 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF3638 PF12340.6 NM_001037913.2_1 - 0.031 13.5 0.1 0.043 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) YihI PF04220.10 NM_001037913.2_1 - 0.05 13.2 2.3 0.087 12.4 2.3 1.3 1 0 0 1 1 1 0 Der GTPase activator (YihI) Baculo_PEP_C PF04513.10 NM_001037913.2_1 - 0.078 12.9 2.7 0.11 12.4 2.7 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus RecA_dep_nuc PF16786.3 NM_001037913.2_3 - 0.026 14.5 0.1 0.054 13.5 0.1 1.5 1 0 0 1 1 1 0 Recombination enhancement, RecA-dependent nuclease SRCR PF00530.16 NM_001113326.1_2 - 2.3e-30 104.9 3.9 5.6e-30 103.7 3.9 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Macscav_rec PF03523.11 NM_001113326.1_2 - 1.5e-25 88.7 4.3 3.8e-25 87.4 4.3 1.7 1 0 0 1 1 1 1 Macrophage scavenger receptor Collagen PF01391.16 NM_001113326.1_2 - 8.4e-14 50.9 64.2 1.2e-08 34.4 26.0 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) SRCR_2 PF15494.4 NM_001113326.1_2 - 5.2e-06 26.8 2.0 1.4e-05 25.4 0.1 2.6 2 1 0 2 2 2 1 Scavenger receptor cysteine-rich domain Reo_sigmaC PF04582.10 NM_001113326.1_2 - 0.0076 15.6 8.5 0.013 14.8 8.5 1.3 1 0 0 1 1 1 1 Reovirus sigma C capsid protein DUF16 PF01519.14 NM_001113326.1_2 - 0.03 14.7 13.7 2.4 8.6 10.6 3.2 2 1 0 2 2 2 0 Protein of unknown function DUF16 SKA2 PF16740.3 NM_001113326.1_2 - 0.23 11.1 12.3 2.4 7.8 0.4 2.7 2 1 0 3 3 2 0 Spindle and kinetochore-associated protein 2 Uds1 PF15456.4 NM_001113326.1_2 - 0.39 10.7 8.0 0.37 10.8 6.4 1.8 1 1 0 1 1 1 0 Up-regulated During Septation MCPsignal PF00015.19 NM_001113326.1_2 - 0.61 9.7 11.1 0.51 9.9 2.9 2.2 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain NPV_P10 PF05531.10 NM_001113326.1_2 - 0.77 10.1 10.2 4.8 7.6 0.7 3.1 3 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein Spectrin PF00435.19 NM_001113326.1_2 - 0.97 9.8 10.5 1.9 8.9 0.2 2.9 3 0 0 3 3 3 0 Spectrin repeat V_ATPase_I PF01496.17 NM_001113326.1_2 - 1.6 6.4 12.5 6.3 4.4 12.0 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Seryl_tRNA_N PF02403.20 NM_001113326.1_2 - 1.6 8.8 10.9 0.12 12.5 2.5 2.8 2 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Laminin_II PF06009.10 NM_001113326.1_2 - 2 8.3 12.7 0.7 9.8 7.6 2.6 1 1 1 2 2 2 0 Laminin Domain II HAUS6_N PF14661.4 NM_001113326.1_2 - 2.2 7.7 9.7 0.64 9.5 5.4 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Exonuc_VII_L PF02601.13 NM_001113326.1_2 - 3.3 7.1 9.5 5 6.5 9.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit TBPIP PF07106.11 NM_001113326.1_2 - 3.8 7.1 15.1 2.4 7.8 10.3 2.6 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF2408 PF10303.7 NM_001113326.1_2 - 7.3 7.0 12.6 2.3e+02 2.2 12.3 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) MitMem_reg PF13012.4 NM_001113326.1_2 - 8.8 6.7 9.7 60 4.0 1.6 2.7 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function DUF342 PF03961.11 NM_001113326.1_2 - 9.4 4.6 12.4 1.7 7.0 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF342) STT3 PF02516.12 NM_008408.4_3 - 6.7e-165 549.6 42.2 5e-160 533.5 37.6 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.4 NM_008408.4_3 - 4.7e-06 26.8 14.4 4.7e-06 26.8 14.4 2.5 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF2985 PF11204.6 NM_008408.4_3 - 0.26 11.3 4.7 0.57 10.3 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2985) 7tm_4 PF13853.4 NM_147079.2_1 - 1.3e-104 349.8 22.1 1.5e-104 349.5 22.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147079.2_1 - 7.1e-20 71.2 18.7 1.3e-19 70.4 18.7 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147079.2_1 - 1e-08 34.8 18.0 1.6e-08 34.1 18.0 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CBX7_C PF17218.1 NM_028763.3_3 - 2.5e-14 52.6 1.3 5.1e-14 51.6 1.3 1.6 1 0 0 1 1 1 1 CBX family C-terminal motif Chromo PF00385.22 NM_028763.3_3 - 3e-14 52.5 0.4 5.8e-14 51.6 0.4 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.4 NM_028763.3_3 - 0.12 12.4 0.3 0.28 11.3 0.3 1.7 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Y_phosphatase PF00102.25 NM_011203.2_3 - 2.1e-80 269.6 0.4 2.9e-80 269.1 0.4 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 NM_011203.2_3 - 0.00045 20.1 0.0 0.00076 19.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 NM_011203.2_3 - 0.02 14.6 0.0 0.042 13.5 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain KRAB PF01352.25 NM_001168502.1_3 - 5.6e-19 67.4 0.6 9e-19 66.7 0.6 1.3 1 0 0 1 1 1 1 KRAB box zf-C2H2 PF00096.24 NM_001168502.1_3 - 1.1e-13 50.7 45.2 8.6e-05 22.7 1.6 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001168502.1_3 - 5.2e-10 39.1 41.4 0.0025 18.4 0.7 6.6 6 0 0 6 6 6 4 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_001168502.1_3 - 0.0018 18.5 46.9 0.019 15.3 1.2 7.3 6 1 0 6 6 6 2 Zinc-finger double domain zf-Di19 PF05605.10 NM_001168502.1_3 - 0.073 13.2 23.0 3.2 8.0 1.8 4.0 2 2 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 NM_001168502.1_3 - 0.34 11.1 23.0 2.7 8.3 0.0 5.8 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding Rad50_zn_hook PF04423.12 NM_001168502.1_3 - 3.1 7.6 6.1 9.5 6.0 0.1 3.7 4 0 0 4 4 4 0 Rad50 zinc hook motif zf-C2H2_9 PF16293.3 NM_001168502.1_3 - 5.6 6.8 13.8 4.1 7.2 0.4 3.6 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_9 PF14369.4 NM_001168502.1_3 - 7.9 6.7 14.1 5.6 7.2 0.1 4.5 4 0 0 4 4 4 0 zinc-ribbon Aldo_ket_red PF00248.19 NM_010598.3_2 - 1.2e-72 244.4 0.0 1.6e-72 244.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family AbLIM_anchor PF16182.3 NM_001252665.1_2 - 5.1e-76 256.8 15.0 3.9e-56 191.4 10.2 2.2 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 NM_001252665.1_2 - 1.8e-14 53.3 0.8 3.7e-14 52.4 0.8 1.6 1 0 0 1 1 1 1 Villin headpiece domain STAT1_TAZ2bind PF12162.6 NM_001252665.1_2 - 2.3 7.8 5.1 10 5.7 0.0 2.8 3 0 0 3 3 3 0 STAT1 TAZ2 binding domain NUDIX PF00293.26 NM_145360.2_3 - 1.1e-22 80.4 0.0 1.7e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain PID PF00640.21 NM_023118.5_2 - 1e-07 31.9 0.0 1.5e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PQ-loop PF04193.12 NM_001164422.1_3 - 3.2e-31 106.8 0.2 2.7e-17 62.1 0.0 3.0 2 1 1 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.16 NM_001164422.1_3 - 0.00066 20.4 3.7 0.31 11.8 0.1 2.4 2 0 0 2 2 2 2 ER lumen protein retaining receptor LPAM_1 PF08139.10 NM_001164422.1_3 - 0.017 15.5 0.8 0.055 13.9 0.8 1.9 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site AA_permease PF00324.19 NM_009195.3_2 - 2.6e-64 217.5 37.6 1.4e-38 132.6 8.1 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 NM_009195.3_2 - 5.1e-47 160.7 3.5 1.2e-29 103.5 2.1 3.0 1 1 1 2 2 2 2 Solute carrier family 12 RasGEF PF00617.17 NM_001204165.1_1 - 2.1e-50 171.2 1.8 3.8e-50 170.3 1.8 1.5 1 0 0 1 1 1 1 RasGEF domain cNMP_binding PF00027.27 NM_001204165.1_1 - 7e-34 115.6 0.0 1.2e-15 57.1 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DEP PF00610.19 NM_001204165.1_1 - 5.2e-20 71.2 3.3 7.4e-20 70.7 1.5 2.1 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RasGEF_N PF00618.18 NM_001204165.1_1 - 1.8e-13 50.5 0.0 4.9e-13 49.1 0.0 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif 7tm_4 PF13853.4 NM_146604.1_1 - 6.5e-57 193.2 18.9 8.2e-57 192.9 18.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146604.1_1 - 3.2e-26 92.0 23.2 1.1e-25 90.2 23.2 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.3 NM_146604.1_1 - 0.6 9.5 4.9 1.8 8.1 4.9 1.7 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus DUF2371 PF10177.7 NM_146604.1_1 - 1.5 8.9 4.5 3.6 7.6 2.0 2.7 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) V1R PF03402.12 NM_134224.1_1 - 3e-42 144.9 17.0 3.8e-42 144.6 17.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_134224.1_1 - 1.7e-09 37.1 23.0 2.3e-09 36.7 23.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) GP4 PF03010.12 NM_134224.1_1 - 0.0067 16.2 0.1 0.016 15.0 0.1 1.7 1 1 0 1 1 1 1 GP4 7tm_1 PF00001.19 NM_134224.1_1 - 0.19 10.8 16.3 0.4 9.7 16.3 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Ndc1_Nup PF09531.8 NM_134224.1_1 - 1.8 7.0 12.9 2.8 6.4 12.9 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RCC1 PF00415.16 NM_027764.2_3 - 1.5e-57 191.8 25.3 4.6e-14 52.6 2.1 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 NM_027764.2_3 - 9.2e-29 98.5 29.1 1.2e-09 37.5 1.3 6.8 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.29 NM_027764.2_3 - 3.9e-20 72.0 0.3 5.2e-19 68.4 0.1 2.2 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.13 NM_027764.2_3 - 3.1e-05 23.9 0.8 0.011 15.7 0.1 3.0 2 1 1 3 3 3 2 BTB And C-terminal Kelch ETRAMP PF09716.8 NM_027764.2_3 - 0.19 11.7 2.9 0.42 10.6 2.9 1.7 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Pkinase PF00069.23 NM_001177974.1_3 - 5e-39 134.1 0.0 7.5e-39 133.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001177974.1_3 - 2.4e-36 125.2 0.0 2.4e-35 121.9 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Death PF00531.20 NM_001177974.1_3 - 9.2e-11 41.6 1.2 1.6e-10 40.9 1.2 1.4 1 0 0 1 1 1 1 Death domain RAMP PF04901.11 NM_001177974.1_3 - 0.006 16.4 0.1 0.012 15.4 0.1 1.4 1 0 0 1 1 1 1 Receptor activity modifying family APH PF01636.21 NM_001177974.1_3 - 0.012 15.4 0.9 0.025 14.4 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.9 NM_001177974.1_3 - 0.25 10.2 0.0 0.53 9.2 0.0 1.4 2 0 0 2 2 2 0 Seadornavirus VP7 Cadherin PF00028.15 NM_009957.1_1 - 3.6e-69 229.1 0.0 6.7e-16 58.4 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 NM_009957.1_1 - 3.9e-63 211.6 4.7 7.7e-63 210.6 4.7 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 NM_009957.1_1 - 2.8e-31 107.0 1.6 3.8e-29 100.2 0.1 4.0 5 0 0 5 5 5 1 Cadherin-like Cadherin_C_2 PF16492.3 NM_009957.1_1 - 1.5e-05 25.5 0.0 4.9e-05 23.9 0.0 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Tektin PF03148.12 NM_011569.3_3 - 1.7e-147 491.1 39.9 1.9e-147 490.9 39.9 1.0 1 0 0 1 1 1 1 Tektin family DUF1664 PF07889.10 NM_011569.3_3 - 0.18 11.7 18.6 0.11 12.3 0.6 4.0 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) RsbRD_N PF14361.4 NM_011569.3_3 - 2.9 8.5 10.7 4.1 8.0 0.3 3.3 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain DUF4140 PF13600.4 NM_011569.3_3 - 4.5 7.6 22.8 1.5 9.2 2.2 4.5 3 2 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Exonuc_VII_L PF02601.13 NM_011569.3_3 - 6.4 6.1 26.9 1.6e+04 -8.8 26.9 2.2 1 1 0 1 1 1 0 Exonuclease VII, large subunit BCOR PF15808.3 NM_029510.3_2 - 1.1e-74 251.3 19.2 4.6e-74 249.2 19.2 2.2 1 0 0 1 1 1 1 BCL-6 co-repressor, non-ankyrin-repeat region PUFD PF16553.3 NM_029510.3_2 - 6.2e-51 171.2 1.2 1.3e-50 170.2 1.2 1.5 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain Ank_2 PF12796.5 NM_029510.3_2 - 7.7e-16 58.3 0.6 3.7e-15 56.1 0.4 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 NM_029510.3_2 - 8.4e-14 50.2 1.4 9.1e-05 22.5 0.2 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.4 NM_029510.3_2 - 1.5e-12 47.3 4.5 2.8e-09 36.9 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 NM_029510.3_2 - 3.1e-11 43.4 7.2 1.6e-06 28.4 0.5 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 NM_029510.3_2 - 1e-09 38.2 1.2 0.0017 18.6 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeat Ras PF00071.20 NM_021411.4_1 - 7.5e-59 197.8 0.1 9.6e-59 197.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_021411.4_1 - 2.3e-31 108.4 0.1 3.4e-31 107.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_021411.4_1 - 1.3e-13 50.7 0.0 1.9e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 NM_021411.4_1 - 1.9e-05 24.0 0.0 2.6e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 NM_021411.4_1 - 0.026 14.5 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF258 PF03193.14 NM_021411.4_1 - 0.038 13.8 0.2 10 5.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DAP3 PF10236.7 NM_021411.4_1 - 0.14 11.1 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Rtf2 PF04641.10 NM_025542.2_1 - 5e-96 321.0 5.3 6.4e-96 320.6 5.3 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.3 NM_025542.2_1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Proteasome PF00227.24 NM_175204.4_3 - 1.5e-38 132.1 0.0 1.9e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit AAA PF00004.27 NM_001310473.1_2 - 1.9e-91 303.2 0.0 4.5e-45 153.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.10 NM_001310473.1_2 - 2.8e-13 49.6 0.1 6e-07 28.8 0.0 2.7 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.4 NM_001310473.1_2 - 3.5e-10 40.4 0.3 0.00018 21.8 0.1 4.2 2 2 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.12 NM_001310473.1_2 - 9.5e-10 38.5 0.1 0.001 18.9 0.0 3.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.11 NM_001310473.1_2 - 3.3e-09 36.1 0.0 0.00028 19.8 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus AAA_2 PF07724.12 NM_001310473.1_2 - 5.4e-08 33.0 0.0 0.0091 16.0 0.0 2.9 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.4 NM_001310473.1_2 - 2.3e-07 30.9 0.0 0.011 15.8 0.0 3.3 4 0 0 4 4 2 2 AAA domain AAA_22 PF13401.4 NM_001310473.1_2 - 4e-07 30.3 0.6 0.023 14.8 0.0 4.3 3 2 2 5 5 5 1 AAA domain Mg_chelatase PF01078.19 NM_001310473.1_2 - 5.4e-07 29.1 0.3 0.013 14.7 0.1 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.4 NM_001310473.1_2 - 4.5e-06 26.2 0.3 0.82 9.1 0.0 4.0 3 1 0 3 3 3 2 AAA domain IstB_IS21 PF01695.15 NM_001310473.1_2 - 1.8e-05 24.5 0.0 0.062 12.9 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.4 NM_001310473.1_2 - 3e-05 24.2 0.0 0.048 13.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.20 NM_001310473.1_2 - 4.6e-05 23.6 0.0 0.2 11.9 0.0 2.5 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.4 NM_001310473.1_2 - 0.00023 21.6 0.0 0.12 12.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.15 NM_001310473.1_2 - 0.00024 20.2 0.1 0.064 12.2 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_3 PF07726.9 NM_001310473.1_2 - 0.00025 20.8 0.0 0.5 10.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.4 NM_001310473.1_2 - 0.00044 20.1 0.0 0.43 10.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain TsaE PF02367.15 NM_001310473.1_2 - 0.00044 20.1 0.0 0.74 9.7 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.4 NM_001310473.1_2 - 0.0014 18.6 0.0 1.3 9.0 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain Rad17 PF03215.13 NM_001310473.1_2 - 0.0015 17.4 0.0 0.084 11.6 0.0 2.2 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein ATPase PF06745.11 NM_001310473.1_2 - 0.0029 16.9 0.0 0.23 10.6 0.0 2.3 2 0 0 2 2 2 1 KaiC AAA_24 PF13479.4 NM_001310473.1_2 - 0.0049 16.5 0.0 0.21 11.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.10 NM_001310473.1_2 - 0.0055 15.9 0.1 2.1 7.4 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin CDC48_N PF02359.16 NM_001310473.1_2 - 0.0091 16.0 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_11 PF13086.4 NM_001310473.1_2 - 0.012 15.2 0.0 1.2 8.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.11 NM_001310473.1_2 - 0.016 14.3 0.0 5.1 6.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.24 NM_001310473.1_2 - 0.018 14.6 0.0 2.4 7.7 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.10 NM_001310473.1_2 - 0.023 14.5 0.2 2 8.2 0.0 2.9 3 0 0 3 3 3 0 NACHT domain AAA_17 PF13207.4 NM_001310473.1_2 - 0.057 13.7 0.0 9.9 6.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.25 NM_001310473.1_2 - 0.1 13.0 0.0 28 5.1 0.0 2.8 2 1 1 3 3 3 0 ABC transporter SKI PF01202.20 NM_001310473.1_2 - 0.14 12.1 0.0 24 4.9 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase Pkinase PF00069.23 NM_001081309.1_3 - 1.6e-18 66.9 0.0 3e-17 62.7 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain WD40 PF00400.30 NM_001081309.1_3 - 2e-11 44.1 14.1 9.1e-05 23.0 0.1 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat HEAT PF02985.20 NM_001081309.1_3 - 2.9e-07 30.0 2.2 0.39 10.9 0.0 5.1 5 0 0 5 5 5 2 HEAT repeat Pkinase_Tyr PF07714.15 NM_001081309.1_3 - 2e-05 23.9 0.0 0.0002 20.6 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase ANAPC4_WD40 PF12894.5 NM_001081309.1_3 - 0.0017 18.4 0.3 1.8 8.8 0.0 4.1 1 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 PF13646.4 NM_001081309.1_3 - 0.011 16.0 0.1 0.23 11.8 0.1 2.9 2 2 1 3 3 3 0 HEAT repeats Adaptin_N PF01602.18 NM_001081309.1_3 - 0.14 10.6 0.7 2.1 6.7 0.3 2.2 1 1 1 2 2 2 0 Adaptin N terminal region IFRD PF05004.11 NM_001081309.1_3 - 0.23 10.4 0.9 0.63 9.0 0.2 2.0 1 1 1 2 2 2 0 Interferon-related developmental regulator (IFRD) V1R PF03402.12 NM_001166722.1_1 - 4.3e-19 69.0 7.5 5.9e-19 68.6 7.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_001166722.1_1 - 8.9e-12 44.6 8.7 1.1e-11 44.3 8.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_001166722.1_1 - 7.9e-06 25.2 9.9 1.1e-05 24.8 9.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Hormone_recep PF00104.28 NM_013839.4_1 - 4.2e-30 104.8 1.2 6.9e-30 104.1 1.2 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 NM_013839.4_1 - 9.4e-27 93.1 14.3 1.6e-26 92.4 14.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) 2Fe-2S_Ferredox PF11591.6 NM_013839.4_2 - 0.03 14.1 1.0 0.03 14.1 1.0 2.9 2 0 0 2 2 2 0 Ferredoxin chloroplastic transit peptide FAM183 PF14886.4 NM_001145360.1_1 - 0.041 14.5 0.1 0.13 12.8 0.0 1.8 2 0 0 2 2 2 0 FAM183A and FAM183B related LLC1 PF14945.4 NM_001145360.1_1 - 0.11 12.9 0.5 0.66 10.4 0.3 2.0 2 0 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Pkinase PF00069.23 NM_021606.3_1 - 9.6e-64 215.1 0.0 1.4e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_021606.3_1 - 5e-46 157.0 0.0 7e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_021606.3_1 - 0.00012 21.4 0.0 0.00022 20.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_021606.3_1 - 0.017 14.3 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GRAM PF02893.18 NM_029066.1_3 - 2.3e-08 33.7 0.0 3.5e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 GRAM domain WW PF00397.24 NM_018765.3_1 - 4e-18 64.9 12.9 2.7e-09 36.7 2.7 2.9 3 0 0 3 3 3 2 WW domain zf-U1 PF06220.10 NM_018765.3_1 - 2e-15 56.1 0.6 2e-15 56.1 0.6 2.2 2 0 0 2 2 2 1 U1 zinc finger PQQ PF01011.19 NM_018765.3_1 - 0.0004 20.0 0.4 0.03 14.1 0.0 2.5 2 0 0 2 2 2 1 PQQ enzyme repeat Pkinase PF00069.23 NM_001161845.2_3 - 2e-69 233.7 0.0 3.1e-69 233.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001161845.2_3 - 4e-35 121.2 0.0 5.9e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001161845.2_3 - 1.8e-06 27.4 0.0 4.3e-06 26.1 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 NM_001161845.2_3 - 7.1e-06 26.5 0.1 1.7e-05 25.2 0.1 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain PX PF00787.22 NM_001161845.2_3 - 0.0099 15.7 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 1 PX domain Kdo PF06293.12 NM_001161845.2_3 - 0.011 14.9 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 NM_001161845.2_3 - 0.03 13.8 0.1 2.6 7.5 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Latexin PF06907.10 NM_001164763.1_1 - 1.8e-99 331.5 0.0 2.3e-99 331.1 0.0 1.1 1 0 0 1 1 1 1 Latexin PX PF00787.22 NM_145458.3_1 - 1.3e-18 66.8 0.0 4.5e-18 65.2 0.0 1.9 1 0 0 1 1 1 1 PX domain Pkinase PF00069.23 NM_145458.3_1 - 3.1e-09 36.4 0.0 5.8e-08 32.3 0.0 2.6 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_145458.3_1 - 1.3e-07 31.1 0.0 1.1e-05 24.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase WH2 PF02205.18 NM_145458.3_1 - 2.8e-07 30.0 0.2 8.6e-07 28.5 0.1 1.9 2 0 0 2 2 2 1 WH2 motif Rrn6 PF10214.7 NM_145458.3_1 - 0.0053 15.1 3.8 0.0071 14.7 3.8 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Carb_anhydrase PF00194.19 NM_011797.2_2 - 9.2e-92 307.0 0.1 1.1e-91 306.7 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Mis12 PF05859.10 NM_001001495.2_1 - 0.06 13.3 4.3 0.11 12.4 4.3 1.4 1 0 0 1 1 1 0 Mis12 protein KASH_CCD PF14662.4 NM_001001495.2_1 - 0.092 12.4 19.5 0.16 11.7 19.5 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH APG6 PF04111.10 NM_001001495.2_1 - 0.64 9.2 16.6 0.93 8.7 16.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Exonuc_VII_L PF02601.13 NM_001001495.2_1 - 1.9 7.9 11.0 2.7 7.4 11.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Vac_Fusion PF02346.14 NM_001001495.2_1 - 4.3 6.9 6.2 11 5.6 2.1 2.5 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 IncA PF04156.12 NM_001001495.2_1 - 4.9 6.8 17.3 21 4.7 17.3 1.9 1 1 0 1 1 1 0 IncA protein DUF4407 PF14362.4 NM_001001495.2_1 - 9 5.4 9.6 14 4.8 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BTB PF00651.29 NM_001302550.1_1 - 7.1e-24 84.0 0.5 1.4e-23 83.1 0.5 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 NM_001302550.1_1 - 5.7e-13 48.5 46.0 1.4e-06 28.4 6.0 7.3 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001302550.1_1 - 8.3e-10 38.5 52.4 0.044 14.5 0.3 7.0 6 0 0 6 6 6 5 C2H2-type zinc finger zf-met PF12874.5 NM_001302550.1_1 - 1.6e-06 28.2 6.4 0.00021 21.4 0.6 7.0 6 1 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2 PF00096.24 NM_001302550.1_1 - 1.1e-05 25.5 57.1 0.03 14.6 0.2 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 NM_001302550.1_1 - 0.0006 19.9 0.9 0.0006 19.9 0.9 6.6 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 NM_001302550.1_1 - 0.0043 16.8 43.1 0.59 10.0 0.1 6.8 6 0 0 6 6 6 3 C2H2-type zinc finger Phage_lysis PF03245.11 NM_001302550.1_1 - 0.2 11.6 0.7 0.39 10.7 0.7 1.4 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein zf-AD PF07776.13 NM_001302550.1_1 - 1.5 9.0 11.3 3.4 7.9 0.2 3.5 3 1 1 4 4 4 0 Zinc-finger associated domain (zf-AD) zinc_ribbon_15 PF17032.3 NM_001302550.1_1 - 3.9 8.1 18.6 11 6.7 1.4 3.6 2 1 1 3 3 3 0 zinc-ribbon family ENTH PF01417.18 NM_183137.2_2 - 9.6e-08 32.0 0.0 1.6e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 ENTH domain ETAA1 PF15350.4 NM_026576.3_1 - 0 1076.5 40.3 0 1076.3 40.3 1.0 1 0 0 1 1 1 1 Ewing's tumour-associated antigen 1 homologue Ephrin_lbd PF01404.17 NM_177671.5_1 - 4e-66 222.3 0.0 5.1e-66 222.0 0.0 1.1 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Tubulin-binding PF00418.17 NM_001205330.1_1 - 1.5e-53 178.3 29.9 8.6e-15 54.3 5.4 4.5 4 0 0 4 4 4 4 Tau and MAP protein, tubulin-binding repeat bZIP_1 PF00170.19 NM_001110859.2_1 - 4.9e-20 71.3 10.5 8.3e-20 70.5 10.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.15 NM_001110859.2_1 - 6.4e-18 63.8 2.3 1.2e-17 62.9 2.3 1.4 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.13 NM_001110859.2_1 - 1.1e-06 28.4 11.2 1.9e-06 27.7 11.2 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_001110859.2_1 - 0.55 10.7 11.7 0.035 14.5 6.4 1.6 2 0 0 2 2 2 0 bZIP Maf transcription factor DnaJ PF00226.29 NM_001190817.1_1 - 5.1e-22 77.6 1.4 9.8e-22 76.7 1.4 1.5 1 0 0 1 1 1 1 DnaJ domain Myb_DNA-binding PF00249.29 NM_001190817.1_1 - 9e-13 48.0 0.5 5.2e-08 32.8 0.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 NM_001190817.1_1 - 0.00011 22.3 0.2 0.062 13.4 0.5 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain XRCC4 PF06632.10 NM_001190817.1_1 - 0.2 10.4 11.7 0.44 9.2 11.7 1.5 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF1443 PF07280.9 NM_001190817.1_2 - 0.48 10.1 2.1 8.1 6.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1443) Tubulin PF00091.23 NM_009449.3_2 - 1.7e-67 227.3 0.0 2.2e-67 226.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 NM_009449.3_2 - 2.4e-51 173.1 0.0 3.8e-51 172.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 NM_009449.3_2 - 0.0017 17.9 0.0 0.0032 17.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Membr_traf_MHD PF10540.7 NM_021468.3_3 - 3.2e-53 179.9 1.6 7.1e-53 178.7 1.6 1.6 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.28 NM_021468.3_3 - 6.6e-53 177.2 10.2 7.4e-27 93.5 0.4 4.1 4 0 0 4 4 4 3 C2 domain DUF1041 PF06292.15 NM_021468.3_3 - 1.9e-34 118.0 0.1 1.9e-34 118.0 0.1 2.0 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1041) C1_1 PF00130.20 NM_021468.3_3 - 1.8e-11 43.6 6.0 4.7e-11 42.3 6.0 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Lectin_leg-like PF03388.11 NM_025828.3_3 - 5.2e-100 333.4 0.0 7.1e-100 333.0 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family RhoGAP PF00620.25 NM_181416.3_3 - 2.2e-32 111.8 0.1 4.1e-32 111.0 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain DUF3511 PF12023.6 NM_181416.3_3 - 0.62 9.8 4.1 0.25 11.1 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3511) Peptidase_S8 PF00082.20 NM_019709.4_1 - 3.3e-39 134.8 0.0 4.7e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 Subtilase family DUF4350 PF14258.4 NM_019709.4_1 - 0.087 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) DUF4195 PF13836.4 NM_001166648.1_3 - 1.6e-57 194.4 29.4 1.6e-57 194.4 29.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4195) zf-Di19 PF05605.10 NM_001166648.1_3 - 0.015 15.4 0.6 0.015 15.4 0.6 6.8 6 3 2 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding SelR PF01641.16 NM_001166648.1_3 - 0.063 13.2 0.0 0.063 13.2 0.0 3.7 4 0 0 4 4 4 0 SelR domain Cadherin PF00028.15 NM_001310608.1_2 - 7.8e-106 346.7 8.5 6.5e-20 71.3 0.1 8.3 8 0 0 8 8 8 8 Cadherin domain Protocadherin PF08374.9 NM_001310608.1_2 - 3.6e-88 295.0 4.4 6.5e-88 294.2 4.4 1.4 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.10 NM_001310608.1_2 - 1.4e-15 56.7 0.6 8.4e-07 28.6 0.0 4.9 5 0 0 5 5 5 3 Cadherin-like TMEM154 PF15102.4 NM_001310608.1_2 - 0.0028 17.4 0.2 0.0059 16.4 0.2 1.5 1 0 0 1 1 1 1 TMEM154 protein family Mid2 PF04478.10 NM_001310608.1_2 - 0.016 14.9 0.2 0.038 13.7 0.2 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Cadherin_pro PF08758.9 NM_001310608.1_2 - 0.022 14.8 0.1 0.09 12.8 0.0 2.0 2 0 0 2 2 2 0 Cadherin prodomain like DUF1510 PF07423.9 NM_001310608.1_2 - 0.038 13.3 0.0 0.064 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) MLANA PF14991.4 NM_001310608.1_2 - 0.096 12.8 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein melan-A DUF3827 PF12877.5 NM_001310608.1_2 - 3.2 5.9 7.7 0.14 10.4 0.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3827) Adeno_E3_CR2 PF02439.13 NM_001310608.1_2 - 6.3 6.5 9.1 0.46 10.1 3.5 2.1 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 DP PF08781.8 NM_001184706.1_2 - 1.9e-60 202.6 3.1 2.9e-60 202.0 3.1 1.3 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.18 NM_001184706.1_2 - 5e-26 90.4 0.3 9.2e-26 89.5 0.3 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain Cation_efflux PF01545.19 NM_001033286.2_1 - 3.1e-41 141.2 0.1 5.3e-41 140.4 0.1 1.4 1 0 0 1 1 1 1 Cation efflux family TMEM240 PF15207.4 NM_001101506.1_2 - 3.1e-106 352.5 1.3 3.9e-106 352.2 1.3 1.1 1 0 0 1 1 1 1 TMEM240 family Ebp2 PF05890.10 NM_026932.4_2 - 4.9e-85 285.2 20.6 6e-85 284.9 20.6 1.1 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 Sec39 PF08314.9 NM_026932.4_2 - 0.0013 17.1 0.7 0.0018 16.7 0.7 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 OmpH PF03938.12 NM_026932.4_2 - 6.2 6.7 16.1 11 5.8 16.1 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SecY PF00344.18 NM_021305.3_1 - 3.3e-77 259.6 12.8 4.3e-77 259.2 12.8 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.7 NM_021305.3_1 - 9.8e-19 66.8 0.2 3.7e-18 64.9 0.2 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p NUDE_C PF04880.11 NM_001285503.1_1 - 6e-47 160.3 0.3 6e-47 160.3 0.3 2.4 2 0 0 2 2 2 1 NUDE protein, C-terminal conserved region TPR_MLP1_2 PF07926.10 NM_001285503.1_1 - 0.098 12.6 34.1 0.13 12.2 10.6 3.1 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF972 PF06156.11 NM_001285503.1_1 - 0.25 11.8 20.8 1.7 9.2 4.5 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Pepsin-I3 PF06394.11 NM_001285503.1_1 - 0.31 11.1 2.4 0.81 9.8 2.4 1.6 1 0 0 1 1 1 0 Pepsin inhibitor-3-like repeated domain ATG16 PF08614.9 NM_001285503.1_1 - 0.62 10.1 38.1 0.73 9.9 19.5 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Lectin_N PF03954.12 NM_001285503.1_1 - 2 8.0 8.4 0.33 10.6 2.9 2.4 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain Phage_GPO PF05929.9 NM_001285503.1_1 - 2.4 7.6 18.5 0.088 12.3 6.1 2.1 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase HALZ PF02183.16 NM_001285503.1_1 - 7.6 6.7 16.1 1.9 8.7 3.1 4.0 4 0 0 4 4 4 0 Homeobox associated leucine zipper PRKG1_interact PF15898.3 NM_001285503.1_1 - 8.1 7.3 28.7 0.03 15.1 10.2 2.7 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF148 PF02520.15 NM_001285503.1_1 - 9.4 6.3 13.5 0.46 10.5 4.4 2.3 1 1 0 2 2 2 0 Domain of unknown function DUF148 Topoisom_bac PF01131.18 NM_001326576.1_3 - 1.2e-117 393.3 0.0 1.5e-117 393.0 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.20 NM_001326576.1_3 - 1.8e-19 69.7 0.0 5e-19 68.3 0.0 1.8 1 0 0 1 1 1 1 Toprim domain FlxA PF14282.4 NM_001277315.1_1 - 0.078 12.8 1.4 0.23 11.3 1.4 1.7 1 0 0 1 1 1 0 FlxA-like protein TBP PF00352.19 NM_199059.2_1 - 2.8e-63 209.7 0.5 9e-31 105.5 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.6 NM_199059.2_1 - 9.9e-07 28.6 0.0 0.044 13.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Plasmodium_HRP PF05403.9 NM_013779.2_1 - 0.048 13.3 5.6 0.072 12.7 5.6 1.1 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) Collagen PF01391.16 NM_013779.2_2 - 2.3e-05 23.9 27.0 2.3e-05 23.9 27.0 5.0 4 1 1 5 5 5 2 Collagen triple helix repeat (20 copies) MAGE PF01454.17 NM_013779.2_3 - 1.6e-15 57.2 0.0 9.6e-14 51.4 0.0 2.2 1 1 0 1 1 1 1 MAGE family Lpp-LpqN PF10738.7 NM_013779.2_3 - 0.39 10.0 3.7 1 8.6 3.7 1.7 1 0 0 1 1 1 0 Probable lipoprotein LpqN LRR_8 PF13855.4 NM_001252132.1_2 - 2.5e-22 78.2 8.7 3.3e-09 36.3 1.2 3.4 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 NM_001252132.1_2 - 7.1e-13 48.4 12.6 0.00071 19.8 1.9 5.3 3 2 2 5 5 5 5 Leucine Rich repeats (2 copies) CH PF00307.29 NM_001252132.1_2 - 2.7e-10 40.3 0.0 4.8e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain LRR_1 PF00560.31 NM_001252132.1_2 - 0.00065 19.7 13.8 2.2 8.9 0.4 5.9 6 0 0 6 6 6 2 Leucine Rich Repeat CAMSAP_CH PF11971.6 NM_001252132.1_2 - 0.038 13.7 0.0 0.092 12.5 0.0 1.6 1 0 0 1 1 1 0 CAMSAP CH domain LRR_6 PF13516.4 NM_001252132.1_2 - 0.059 13.3 9.0 3.1 8.0 0.6 4.6 4 0 0 4 4 4 0 Leucine Rich repeat SelP_N PF04592.12 NM_001252132.1_2 - 2.5 7.3 6.0 5 6.3 6.0 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region MCM PF00493.21 NM_025676.4_2 - 1.8e-125 418.3 0.0 2.3e-125 418.0 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 NM_025676.4_2 - 3.7e-25 88.1 0.4 6.2e-25 87.4 0.4 1.3 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.19 NM_025676.4_2 - 7.7e-08 31.8 0.0 0.00013 21.3 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 NM_025676.4_2 - 2.5e-07 30.6 0.0 6.1e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.9 NM_025676.4_2 - 5.1e-05 23.0 0.0 0.00021 21.0 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 NM_025676.4_2 - 0.045 14.0 0.0 0.2 11.9 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.13 NM_025676.4_2 - 0.045 13.5 1.1 1.3 8.7 0.1 2.9 3 0 0 3 3 3 0 NTPase AAA PF00004.27 NM_025676.4_2 - 0.057 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.16 NM_025676.4_2 - 0.098 11.9 0.0 0.31 10.2 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Prothymosin PF03247.12 NM_026988.2_1 - 4e-13 49.6 46.8 5.1e-13 49.3 46.8 1.1 1 0 0 1 1 1 1 Prothymosin/parathymosin family CDC27 PF09507.8 NM_026988.2_1 - 0.0015 17.9 13.8 0.0019 17.6 13.8 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 TFIIA PF03153.11 NM_026988.2_1 - 0.13 12.1 9.9 0.16 11.8 9.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Drc1-Sld2 PF11719.6 NM_026988.2_1 - 0.17 11.3 13.9 0.22 10.9 13.9 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein Paf1 PF03985.11 NM_026988.2_1 - 1.5 7.6 21.2 1.8 7.3 21.2 1.1 1 0 0 1 1 1 0 Paf1 CDC45 PF02724.12 NM_026988.2_1 - 4.1 5.5 20.2 5.3 5.1 20.2 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.4 NM_026988.2_1 - 5.8 6.7 9.7 8.5 6.2 9.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Sulfate_transp PF00916.18 NM_001289788.1_1 - 4.5e-18 65.0 4.3 7.8e-18 64.3 4.3 1.3 1 1 0 1 1 1 1 Sulfate permease family Sulfate_transp PF00916.18 NM_001289788.1_3 - 4.8e-57 193.3 3.6 7.1e-57 192.7 3.6 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 NM_001289788.1_3 - 1.1e-24 86.2 0.0 1.8e-24 85.5 0.0 1.3 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.4 NM_001289788.1_3 - 0.011 15.9 0.0 0.024 14.8 0.0 1.5 1 0 0 1 1 1 0 STAS domain Cadherin PF00028.15 NM_033575.3_1 - 4.5e-78 257.7 0.0 4.3e-18 65.4 0.2 6.2 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_033575.3_1 - 7.8e-32 108.8 0.0 5.2e-28 96.5 0.0 3.9 4 0 0 4 4 4 2 Cadherin-like Cadherin_tail PF15974.3 NM_033575.3_1 - 1.7e-25 89.8 2.8 1.7e-25 89.8 2.8 3.4 2 1 0 2 2 2 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 NM_033575.3_1 - 1.8e-23 83.0 0.4 1.8e-23 83.0 0.4 2.0 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal DUF4958 PF16319.3 NM_033575.3_1 - 0.011 13.8 0.1 0.019 13.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4958) tRNA-synt_1 PF00133.20 NM_153168.2_1 - 1e-45 156.0 0.2 8.4e-25 86.9 2.4 6.1 3 1 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.9 NM_153168.2_1 - 4.9e-29 101.2 0.0 9.7e-19 67.3 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.11 NM_153168.2_1 - 1.6e-11 44.2 0.0 3.1e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.4 NM_153168.2_1 - 1.7e-09 37.3 0.0 2.6e-07 30.2 0.0 2.3 1 1 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.17 NM_153168.2_1 - 0.0029 16.9 0.0 2.1 7.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.16 NM_153168.2_1 - 0.049 12.4 0.0 1.8 7.2 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (K) R3H PF01424.20 NM_001177619.1_1 - 4.8e-13 48.8 1.2 4.4e-12 45.7 0.1 2.9 3 0 0 3 3 3 1 R3H domain SUZ PF12752.5 NM_001177619.1_1 - 7.4e-13 48.9 4.7 7.4e-13 48.9 4.7 2.9 3 1 0 3 3 3 1 SUZ domain PPARgamma_N PF12577.6 NM_001308354.1_2 - 1e-32 112.5 0.5 4.2e-32 110.5 1.1 1.8 2 0 0 2 2 2 1 PPAR gamma N-terminal region zf-C4 PF00105.16 NM_001308354.1_2 - 2.2e-27 95.2 15.0 3.6e-27 94.5 15.0 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001308354.1_2 - 2.2e-15 56.7 0.1 5.4e-15 55.4 0.1 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 NM_001308354.1_2 - 0.023 13.7 2.7 0.037 13.0 2.7 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A 7tm_3 PF00003.20 NM_001104579.1_1 - 1.3e-59 201.7 28.4 3.2e-59 200.4 28.4 1.7 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 NM_001104579.1_1 - 2.2e-29 102.6 0.9 8.3e-29 100.6 0.9 1.8 1 1 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 NM_001104579.1_1 - 1.7e-16 59.8 10.5 5.5e-16 58.1 10.5 1.9 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Cytochrom_C1 PF02167.13 NM_001104579.1_1 - 0.094 12.3 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C1 family G-gamma PF00631.20 NM_001177559.1_2 - 1.1e-15 57.3 0.0 1.8e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 GGL domain K_channel_TID PF07941.9 NM_001177559.1_2 - 0.86 10.0 7.3 1.2 9.5 3.9 2.2 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain CH PF00307.29 NM_178598.2_2 - 3.2e-23 81.9 0.0 5e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.16 NM_178598.2_2 - 2.1e-13 49.5 6.1 4.3e-13 48.5 6.1 1.5 1 0 0 1 1 1 1 Calponin family repeat CDC24 PF06395.9 NM_178598.2_2 - 0.0023 18.1 0.0 0.0037 17.4 0.0 1.2 1 0 0 1 1 1 1 CDC24 Calponin CAMSAP_CH PF11971.6 NM_178598.2_2 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain Hormone_1 PF00103.18 NM_029355.2_1 - 9.1e-58 195.4 0.5 1.1e-57 195.1 0.5 1.1 1 0 0 1 1 1 1 Somatotropin hormone family KIAA1430 PF13879.4 NM_029355.2_1 - 0.027 15.1 0.0 0.059 14.0 0.0 1.5 2 0 0 2 2 2 0 KIAA1430 homologue DUF851 PF05867.9 NM_029355.2_1 - 0.082 12.2 0.1 0.15 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF851) TYW3 PF02676.12 NM_001168358.1_1 - 1.1e-37 129.3 0.1 1.1e-37 129.3 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase TYW3 RRXRR PF14239.4 NM_001168358.1_1 - 0.085 12.6 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 RRXRR protein DAGK_cat PF00781.22 NM_001172472.1_2 - 1.3e-25 89.3 0.0 3.3e-25 88.0 0.0 1.7 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain 7tm_1 PF00001.19 NM_134438.3_1 - 1.6e-23 83.2 9.6 2.6e-23 82.5 9.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_2 PF00002.22 NM_018882.3_1 - 5.4e-27 94.5 17.8 8e-27 94.0 17.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 NM_018882.3_1 - 3.8e-14 52.9 4.9 3.8e-14 52.9 4.9 2.7 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif Rad52_Rad22 PF04098.13 NM_001166383.1_2 - 4.3e-48 163.0 0.8 6.8e-48 162.3 0.0 1.6 2 0 0 2 2 2 1 Rad52/22 family double-strand break repair protein BTB PF00651.29 NM_001115130.1_3 - 1.6e-28 99.0 0.6 2.4e-28 98.5 0.6 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 NM_001115130.1_3 - 5.5e-07 29.6 6.0 0.0002 21.5 1.2 3.3 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001115130.1_3 - 7.4e-07 29.2 11.0 0.00075 19.7 0.4 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001115130.1_3 - 1.1e-05 25.7 9.4 0.012 16.3 0.3 3.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001115130.1_3 - 2.3e-05 24.1 6.3 0.0093 15.8 0.1 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.3 NM_001115130.1_3 - 0.00012 21.6 6.9 0.06 13.0 0.3 3.0 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-met PF12874.5 NM_001115130.1_3 - 0.001 19.2 10.3 0.053 13.8 0.1 3.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type GAS PF13851.4 NM_018855.2_2 - 7.7e-79 263.6 28.0 7.7e-79 263.6 28.0 2.5 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Virulence_fact PF13769.4 NM_018855.2_2 - 0.013 15.5 0.6 0.013 15.5 0.6 4.8 3 1 1 5 5 5 0 Virulence factor Methyltrn_RNA_4 PF09936.7 NM_018855.2_2 - 0.13 12.0 5.9 0.055 13.2 1.1 2.6 1 1 2 3 3 3 0 SAM-dependent RNA methyltransferase WD40 PF00400.30 NM_026399.2_3 - 4e-32 109.6 11.8 5.4e-06 26.9 0.3 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_026399.2_3 - 1.4e-07 31.6 0.0 0.29 11.3 0.0 4.5 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_026399.2_3 - 0.00046 19.5 0.0 0.001 18.3 0.0 1.6 1 0 0 1 1 1 1 WD40-like domain PQQ_2 PF13360.4 NM_026399.2_3 - 0.0027 17.2 0.3 0.018 14.5 0.3 2.2 1 1 0 1 1 1 1 PQQ-like domain Nup160 PF11715.6 NM_026399.2_3 - 0.11 11.0 0.3 11 4.4 0.0 3.0 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Cadherin PF00028.15 NM_007667.3_3 - 3e-78 258.2 1.3 5.8e-17 61.8 0.0 5.4 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 NM_007667.3_3 - 5.1e-53 178.8 0.1 1.1e-52 177.6 0.0 1.6 2 0 0 2 2 2 1 Cadherin cytoplasmic region Cadherin_2 PF08266.10 NM_007667.3_3 - 0.0028 17.3 0.0 2.2 8.0 0.0 3.4 3 0 0 3 3 3 2 Cadherin-like DUF761 PF05553.9 NM_007667.3_3 - 0.067 12.6 1.1 0.7 9.4 0.2 2.5 2 0 0 2 2 2 0 Cotton fibre expressed protein AbLIM_anchor PF16182.3 NM_001164491.1_1 - 2.4e-149 498.1 24.8 3.1e-149 497.7 24.8 1.1 1 0 0 1 1 1 1 Putative adherens-junction anchoring region of AbLIM LIM PF00412.20 NM_001164491.1_1 - 2e-40 136.7 48.6 4.1e-14 52.4 4.9 4.7 4 1 0 4 4 4 4 LIM domain VHP PF02209.17 NM_001164491.1_1 - 9.4e-16 57.5 0.4 5e-15 55.1 1.2 1.9 2 0 0 2 2 2 1 Villin headpiece domain FYVE PF01363.19 NM_024413.2_2 - 2.8e-17 62.5 6.5 7.2e-17 61.2 6.5 1.7 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.27 NM_024413.2_2 - 3e-09 37.2 0.1 5.2e-09 36.4 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_13 PF16652.3 NM_024413.2_2 - 0.00091 19.0 1.5 0.023 14.5 1.5 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain FYVE_2 PF02318.14 NM_024413.2_2 - 0.017 15.2 7.5 0.04 14.0 7.5 1.7 1 1 0 1 1 1 0 FYVE-type zinc finger IQ_SEC7_PH PF16453.3 NM_024413.2_2 - 0.021 14.7 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 PH domain PH_6 PF15406.4 NM_024413.2_2 - 0.094 12.9 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain C1_2 PF03107.14 NM_024413.2_2 - 1.1 9.4 8.6 2.2 8.5 4.8 2.8 3 0 0 3 3 3 0 C1 domain WD40 PF00400.30 NM_144824.2_3 - 4.6e-19 68.3 11.8 5e-05 23.8 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_144824.2_3 - 0.0002 21.4 0.0 28 5.0 0.0 5.0 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.23 NM_001310703.1_1 - 9.2e-71 238.1 0.0 1.2e-70 237.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001310703.1_1 - 1.7e-38 132.3 0.0 2.4e-38 131.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 NM_001310703.1_1 - 3e-09 36.5 0.0 4.9e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 NM_001310703.1_1 - 1.5e-07 31.1 0.1 2.7e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 NM_001310703.1_1 - 4.7e-06 26.6 0.0 1.1e-05 25.3 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.12 NM_001310703.1_1 - 0.00015 21.1 0.1 0.00024 20.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.9 NM_001310703.1_1 - 0.0039 16.2 0.1 0.006 15.5 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Choline_kinase PF01633.18 NM_001310703.1_1 - 0.011 15.2 0.1 0.017 14.6 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase YukC PF10140.7 NM_001310703.1_1 - 0.14 10.9 0.1 0.2 10.3 0.1 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC YrbL-PhoP_reg PF10707.7 NM_001310703.1_1 - 0.15 11.5 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL 7tm_4 PF13853.4 NM_001011779.1_3 - 1.1e-50 172.8 12.2 1.5e-50 172.4 12.2 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011779.1_3 - 1.8e-22 79.8 17.6 4e-22 78.6 17.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1772 PF08592.9 NM_001011779.1_3 - 0.065 13.4 0.1 0.065 13.4 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) EMP70 PF02990.14 NM_001011779.1_3 - 7.3 5.0 18.3 0.18 10.3 11.6 1.5 2 0 0 2 2 2 0 Endomembrane protein 70 JAB PF01398.19 NM_026530.5_2 - 6.1e-09 35.7 0.0 1.2e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 NM_026530.5_2 - 1.1e-07 31.5 0.0 2.3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Histone PF00125.22 NM_001081019.1_2 - 8e-53 178.2 0.7 1.1e-52 177.8 0.7 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.4 NM_001081019.1_2 - 0.0008 19.6 0.0 0.0014 18.9 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.4 NM_001081019.1_2 - 0.0014 18.5 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Ig_2 PF13895.4 NM_177915.4_3 - 8.8e-15 54.7 0.1 6.3e-07 29.5 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_177915.4_3 - 0.00073 19.5 0.3 0.43 10.7 0.3 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 NM_177915.4_3 - 0.0012 19.2 0.2 1.6 9.3 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 NM_177915.4_3 - 0.0014 18.6 0.0 2.6 8.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain zf-UBP PF02148.17 NM_183199.3_2 - 2.6e-19 69.2 9.8 6.5e-19 67.9 9.8 1.7 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.27 NM_183199.3_2 - 2.1e-10 40.4 0.0 2.5e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase 7tm_1 PF00001.19 NM_175490.4_3 - 5.1e-17 61.9 16.7 7.7e-17 61.3 16.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 NM_146280.1_1 - 1.1e-53 182.7 15.1 1.3e-53 182.4 15.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146280.1_1 - 3.4e-22 78.8 16.8 7e-22 77.8 16.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146280.1_1 - 7.1e-05 22.2 14.0 0.00015 21.1 14.0 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TRH PF05438.10 NM_009426.3_1 - 2.7e-30 105.6 5.9 1e-16 61.2 1.2 2.2 2 0 0 2 2 2 2 Thyrotropin-releasing hormone (TRH) Y_phosphatase PF00102.25 NM_001127177.1_1 - 1e-76 257.5 0.1 1.4e-76 257.0 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase zf-H2C2_2 PF13465.4 NM_001310742.1_3 - 4.6e-67 219.5 88.6 1.7e-09 37.5 1.0 13.6 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001310742.1_3 - 1.4e-51 170.1 88.2 2.7e-06 27.4 3.2 12.7 12 0 0 12 12 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001310742.1_3 - 7.5e-33 110.2 83.6 0.00078 19.9 2.7 12.6 12 0 0 12 12 11 11 C2H2-type zinc finger KRAB PF01352.25 NM_001310742.1_3 - 1.2e-23 82.4 0.6 2.3e-23 81.5 0.6 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 NM_001310742.1_3 - 1.7e-19 69.2 72.8 0.0036 17.1 1.4 12.3 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 NM_001310742.1_3 - 8.5e-07 29.0 57.9 0.22 11.8 1.4 11.4 12 0 0 12 12 12 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 NM_001310742.1_3 - 1.1e-06 28.5 53.5 0.018 15.0 0.4 8.3 5 2 3 9 9 9 5 Zinc ribbon domain zf-trcl PF13451.4 NM_001310742.1_3 - 0.00024 20.8 45.8 6.8 6.5 0.2 11.1 10 1 0 10 10 10 2 Probable zinc-ribbon domain zf-C2H2_11 PF16622.3 NM_001310742.1_3 - 0.0013 18.4 0.2 0.0013 18.4 0.2 10.8 11 0 0 11 11 11 3 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 NM_001310742.1_3 - 0.0028 18.2 46.9 0.32 11.6 4.3 6.5 1 1 8 9 9 9 6 zinc-ribbon family XPA_N PF01286.16 NM_001310742.1_3 - 0.0055 16.6 52.0 2.5 8.1 0.1 11.8 12 0 0 12 12 12 3 XPA protein N-terminal zf-met PF12874.5 NM_001310742.1_3 - 0.016 15.4 2.3 0.016 15.4 2.3 10.1 10 0 0 10 10 10 0 Zinc-finger of C2H2 type DUF3268 PF11672.6 NM_001310742.1_3 - 1.7 8.8 41.0 0.033 14.4 1.7 6.1 2 2 2 7 7 7 0 zinc-finger-containing domain 7tm_4 PF13853.4 NM_001011863.1_1 - 1e-55 189.3 19.2 1.2e-55 189.1 19.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011863.1_1 - 3.3e-27 95.3 23.4 8.8e-27 93.9 23.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011863.1_1 - 0.0064 15.8 20.4 0.011 15.0 20.4 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Arm PF00514.21 NM_001011863.1_1 - 0.045 13.7 0.2 0.14 12.1 0.2 1.9 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat 7TM_GPCR_Srx PF10328.7 NM_001011863.1_1 - 0.059 12.5 17.0 0.017 14.3 13.9 1.7 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Oxysterol_BP PF01237.16 NM_001302631.1_2 - 2.3e-142 474.1 0.1 2.9e-142 473.8 0.1 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein zf-C2H2 PF00096.24 NM_001081098.1_1 - 7.4e-26 89.0 51.7 5e-05 23.4 1.2 6.8 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_001081098.1_1 - 1.4e-21 75.7 61.9 8.5e-07 29.0 1.0 8.3 8 0 0 8 8 8 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 NM_001081098.1_1 - 7.9e-13 47.9 62.7 0.0041 17.7 2.3 7.5 8 0 0 8 8 6 6 C2H2-type zinc finger zf-C2HC_2 PF13913.4 NM_001081098.1_1 - 1.8e-05 24.3 5.1 0.0082 15.9 0.6 4.8 4 0 0 4 4 4 1 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.4 NM_001081098.1_1 - 8.4e-05 22.3 41.1 0.031 14.1 3.3 6.6 6 0 0 6 6 6 3 C2H2-type zinc finger zf-Di19 PF05605.10 NM_001081098.1_1 - 0.0066 16.6 37.4 0.0094 16.1 9.7 4.6 2 1 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 NM_001081098.1_1 - 0.019 15.2 0.4 0.019 15.2 0.4 6.0 6 1 1 7 7 6 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 NM_001081098.1_1 - 0.064 12.9 17.0 0.11 12.2 1.9 4.4 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-met PF12874.5 NM_001081098.1_1 - 1.5 9.2 44.4 0.56 10.5 2.0 5.9 6 0 0 6 6 6 0 Zinc-finger of C2H2 type NMD3 PF04981.11 NM_001081098.1_1 - 2 7.7 7.7 1.9 7.7 1.7 2.3 2 0 0 2 2 2 0 NMD3 family zf-C2HE PF16278.3 NM_001081098.1_1 - 6.6 7.1 21.4 1.6 9.1 1.2 3.6 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger dCMP_cyt_deam_1 PF00383.21 NM_178788.4_1 - 2.4e-27 94.6 0.1 3.8e-27 94.0 0.1 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 NM_178788.4_1 - 2e-13 50.1 0.0 2.8e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Mito_carr PF00153.25 NM_172577.3_3 - 1.5e-57 191.4 1.2 1.8e-21 75.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Trypsin PF00089.24 NM_001313938.1_3 - 1.9e-66 223.9 0.0 2.5e-66 223.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 NM_001313938.1_3 - 2.5e-19 69.1 5.4 5.2e-19 68.0 5.4 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 NM_001313938.1_3 - 3.8e-11 42.9 27.2 2.2e-10 40.5 9.2 2.9 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site EGF PF00008.25 NM_001313938.1_3 - 5.4e-07 29.7 23.9 0.00023 21.3 11.1 2.7 2 0 0 2 2 2 2 EGF-like domain Trypsin_2 PF13365.4 NM_001313938.1_3 - 4.4e-06 27.5 0.0 7.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain hEGF PF12661.5 NM_001313938.1_3 - 3.6e-05 24.1 18.1 0.00062 20.2 6.6 3.3 2 0 0 2 2 2 2 Human growth factor-like EGF DUF1986 PF09342.9 NM_001313938.1_3 - 5e-05 23.5 0.5 0.00016 21.9 0.1 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF1986) EGF_2 PF07974.11 NM_001313938.1_3 - 0.0086 16.3 15.9 0.0086 16.3 15.9 3.0 2 0 0 2 2 2 1 EGF-like domain cEGF PF12662.5 NM_001313938.1_3 - 0.011 15.5 0.4 0.011 15.5 0.4 3.0 3 0 0 3 3 3 0 Complement Clr-like EGF-like EGF_CA PF07645.13 NM_001313938.1_3 - 7.1 6.8 30.8 0.2 11.7 13.9 3.5 2 1 1 3 3 3 0 Calcium-binding EGF domain DUF3498 PF12004.6 NM_001290637.1_3 - 2.3e-194 647.3 9.5 2.3e-194 647.3 9.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3498) RasGAP PF00616.17 NM_001290637.1_3 - 5.1e-27 94.8 5.6 1.5e-14 54.1 0.0 3.1 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.28 NM_001290637.1_3 - 3.8e-08 33.4 0.0 6.7e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 C2 domain Bacillus_HBL PF05791.9 NM_001290637.1_3 - 0.00018 21.1 5.0 0.00036 20.2 5.0 1.4 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) PH_2 PF08458.8 NM_001290637.1_3 - 0.015 15.5 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH PF00169.27 NM_001290637.1_3 - 0.018 15.4 0.3 0.061 13.7 0.0 2.1 2 0 0 2 2 2 0 PH domain Med4 PF10018.7 NM_001290637.1_3 - 0.5 9.9 6.7 1.1 8.7 6.7 1.6 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 EMP24_GP25L PF01105.22 NM_001290637.1_3 - 1.3 8.8 4.3 2.4 7.9 4.3 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Gly_acyl_tr_N PF06021.9 NM_001290637.1_3 - 1.6 8.7 5.2 3.1 7.7 5.2 1.3 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase DUF4407 PF14362.4 NM_001290637.1_3 - 1.9 7.6 6.9 3.5 6.8 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.13 NM_001290637.1_3 - 2 7.8 5.4 3.5 7.0 5.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit XLF PF09302.9 NM_001290637.1_3 - 6.2 6.8 7.1 15 5.6 7.1 1.6 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component TMCO5 PF14992.4 NM_026104.4_3 - 6.6e-110 366.9 20.0 8.2e-110 366.6 20.0 1.1 1 0 0 1 1 1 1 TMCO5 family Vac_Fusion PF02346.14 NM_026104.4_3 - 0.011 15.2 11.3 0.89 9.1 0.1 3.5 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 VGPC1_C PF16799.3 NM_026104.4_3 - 0.055 13.3 8.7 0.2 11.5 0.8 3.2 3 0 0 3 3 3 0 C-terminal membrane-localisation domain of ion-channel, VCN1 TMEM191C PF15194.4 NM_026104.4_3 - 0.089 12.8 0.3 0.18 11.8 0.3 1.5 1 0 0 1 1 1 0 TMEM191C family Synaptobrevin PF00957.19 NM_026104.4_3 - 0.1 12.3 1.7 0.22 11.2 1.7 1.6 1 0 0 1 1 1 0 Synaptobrevin V_ATPase_I PF01496.17 NM_026104.4_3 - 0.12 10.1 12.0 0.21 9.3 12.0 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-5_eIF-2B PF01873.15 NM_026104.4_3 - 0.22 11.3 5.3 0.051 13.3 0.7 2.2 2 1 1 3 3 3 0 Domain found in IF2B/IF5 Syntaxin_2 PF14523.4 NM_026104.4_3 - 0.82 9.9 13.0 1.1 9.5 10.8 2.3 1 1 1 2 2 2 0 Syntaxin-like protein DUF2852 PF11014.6 NM_026104.4_3 - 2.2 8.3 5.9 0.42 10.6 2.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) DUF3037 PF11236.6 NM_026104.4_3 - 2.2 8.6 7.1 32 4.8 4.6 3.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) CENP-H PF05837.10 NM_026104.4_3 - 4.8 7.5 28.4 2.4 8.5 10.6 3.0 1 1 2 3 3 3 0 Centromere protein H (CENP-H) CENP-F_leu_zip PF10473.7 NM_026104.4_3 - 6.6 6.6 43.5 3.7 7.4 24.2 2.7 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V-set PF07686.15 NM_001004152.2_2 - 1.5e-41 140.8 2.1 9e-11 41.8 0.0 5.0 4 1 1 5 5 5 4 Immunoglobulin V-set domain Ig_3 PF13927.4 NM_001004152.2_2 - 4.5e-25 87.9 0.3 8.9e-09 35.7 0.1 4.5 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 NM_001004152.2_2 - 8.5e-22 76.9 0.1 3.1e-09 36.6 0.0 4.5 4 1 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.23 NM_001004152.2_2 - 1.8e-16 59.9 5.6 9.7e-09 35.2 0.3 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 NM_001004152.2_2 - 2.4e-16 59.7 2.2 2.3e-07 30.9 0.3 5.0 4 3 0 4 4 4 4 Immunoglobulin domain Receptor_2B4 PF11465.6 NM_001004152.2_2 - 6.9e-08 32.5 0.7 1 9.5 0.1 4.2 4 0 0 4 4 4 3 Natural killer cell receptor 2B4 Izumo-Ig PF16706.3 NM_001004152.2_2 - 0.054 13.4 0.2 1.5 8.8 0.0 3.1 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain UPAR_LY6 PF00021.19 NM_026730.1_1 - 0.00015 22.3 17.4 0.0002 21.8 17.4 1.2 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Toxin_1 PF00087.19 NM_026730.1_1 - 0.0086 16.2 16.0 0.012 15.7 16.0 1.2 1 0 0 1 1 1 1 Snake toxin Calreticulin PF00262.16 NM_001110499.1_2 - 4.8e-167 555.3 13.1 4.8e-167 555.3 13.1 1.4 2 0 0 2 2 2 1 Calreticulin family DUF1510 PF07423.9 NM_001110499.1_2 - 4.4e-06 26.2 3.5 9.4e-06 25.1 3.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) MAP17 PF15807.3 NM_001110499.1_2 - 0.072 13.2 2.1 0.16 12.0 2.1 1.5 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TRAP_alpha PF03896.14 NM_001110499.1_2 - 0.14 11.2 5.8 0.19 10.8 3.0 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.4 NM_001110499.1_2 - 0.16 11.5 2.3 0.51 9.9 2.3 1.8 1 0 0 1 1 1 0 FAM176 family Astro_capsid_p PF12226.6 NM_001110499.1_2 - 0.23 10.4 2.7 0.49 9.3 2.7 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Roughex PF06020.9 NM_001110499.1_2 - 1.9 7.4 11.1 4.8 6.1 11.1 1.6 1 0 0 1 1 1 0 Drosophila roughex protein CDC45 PF02724.12 NM_001110499.1_2 - 3 5.9 10.0 4.5 5.3 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein PAS_3 PF08447.10 NM_001313919.1_1 - 3.6e-27 94.3 0.2 3.3e-21 75.2 0.1 2.4 2 0 0 2 2 2 2 PAS fold HIF-1a_CTAD PF08778.8 NM_001313919.1_1 - 6.1e-22 76.8 0.5 1.2e-21 75.9 0.5 1.5 1 0 0 1 1 1 1 HIF-1 alpha C terminal transactivation domain PAS_11 PF14598.4 NM_001313919.1_1 - 1.3e-21 76.7 1.0 1.6e-19 70.0 0.1 2.7 3 0 0 3 3 3 1 PAS domain HIF-1 PF11413.6 NM_001313919.1_1 - 3e-15 55.2 6.3 5.6e-15 54.3 6.3 1.5 1 0 0 1 1 1 1 Hypoxia-inducible factor-1 PAS PF00989.23 NM_001313919.1_1 - 3e-15 56.1 0.0 7.6e-07 29.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.5 NM_001313919.1_1 - 3.6e-09 36.7 0.0 0.0012 18.9 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 NM_001313919.1_1 - 1.2e-06 28.6 0.0 0.019 15.1 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 NM_001313919.1_1 - 0.07 13.0 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain AAA PF00004.27 NM_009503.4_3 - 3.1e-96 318.7 0.0 6.9e-47 159.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.16 NM_009503.4_3 - 2.1e-21 75.8 0.3 7.7e-21 73.9 0.3 2.1 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.10 NM_009503.4_3 - 5e-13 48.7 0.0 2.4e-05 23.6 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.4 NM_009503.4_3 - 1.4e-12 48.2 5.1 5.4e-05 23.5 0.1 4.7 4 2 1 5 5 4 2 AAA ATPase domain CDC48_2 PF02933.15 NM_009503.4_3 - 1.9e-12 46.6 0.0 3.7e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.4 NM_009503.4_3 - 2.7e-10 40.4 0.0 8.6e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.12 NM_009503.4_3 - 3.5e-10 40.1 0.0 5.4e-05 23.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.12 NM_009503.4_3 - 4.4e-10 39.6 0.1 6.8e-05 22.7 0.0 3.1 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 NM_009503.4_3 - 6.8e-09 36.0 0.9 0.02 15.1 0.1 4.0 3 2 0 3 3 2 2 AAA domain Vps4_C PF09336.8 NM_009503.4_3 - 1.8e-08 34.1 1.0 4.5e-05 23.2 0.1 2.6 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain TIP49 PF06068.11 NM_009503.4_3 - 1.9e-08 33.6 0.0 0.0015 17.4 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus AAA_18 PF13238.4 NM_009503.4_3 - 3.7e-07 30.6 0.0 0.031 14.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.20 NM_009503.4_3 - 4.6e-07 30.1 0.0 0.0089 16.3 0.0 2.9 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.19 NM_009503.4_3 - 6.9e-07 28.7 0.1 0.026 13.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.15 NM_009503.4_3 - 7.6e-07 28.9 0.1 0.055 13.1 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.4 NM_009503.4_3 - 1.1e-06 28.5 0.0 0.034 14.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.15 NM_009503.4_3 - 6.3e-06 25.3 0.1 0.046 12.7 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_28 PF13521.4 NM_009503.4_3 - 1.2e-05 25.5 0.0 0.25 11.4 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.4 NM_009503.4_3 - 1.2e-05 24.8 0.5 2.1 7.7 0.0 3.6 2 1 0 3 3 3 1 AAA domain ATPase PF06745.11 NM_009503.4_3 - 1.7e-05 24.1 0.1 0.63 9.2 0.0 3.4 3 0 0 3 3 3 2 KaiC ATPase_2 PF01637.16 NM_009503.4_3 - 2.2e-05 24.4 0.2 0.32 10.7 0.0 3.6 2 2 1 4 4 3 1 ATPase domain predominantly from Archaea Bac_DnaA PF00308.16 NM_009503.4_3 - 2.4e-05 24.2 0.0 0.12 12.0 0.0 2.9 3 0 0 3 3 2 2 Bacterial dnaA protein ABC_tran PF00005.25 NM_009503.4_3 - 2.5e-05 24.7 0.1 0.015 15.7 0.0 3.3 2 1 0 2 2 2 1 ABC transporter DUF815 PF05673.11 NM_009503.4_3 - 3.3e-05 23.1 0.0 0.017 14.1 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.4 NM_009503.4_3 - 9.6e-05 22.0 0.2 0.12 12.0 0.0 2.6 2 1 0 2 2 2 2 AAA domain TsaE PF02367.15 NM_009503.4_3 - 0.00014 21.8 0.0 0.4 10.5 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.16 NM_009503.4_3 - 0.00016 21.4 0.0 0.0025 17.4 0.0 2.6 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.24 NM_009503.4_3 - 0.00023 20.7 0.0 0.6 9.7 0.0 2.7 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.4 NM_009503.4_3 - 0.0003 21.1 0.1 1.5 9.1 0.0 3.0 3 0 0 3 3 2 2 AAA domain NACHT PF05729.10 NM_009503.4_3 - 0.00037 20.3 0.1 0.41 10.4 0.0 3.3 3 1 1 4 4 4 1 NACHT domain Zeta_toxin PF06414.10 NM_009503.4_3 - 0.0011 18.2 0.0 0.56 9.3 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.20 NM_009503.4_3 - 0.0013 17.7 0.0 0.32 9.9 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain DUF2075 PF09848.7 NM_009503.4_3 - 0.0015 17.7 0.0 0.54 9.3 0.0 2.5 3 0 0 3 3 2 1 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.9 NM_009503.4_3 - 0.0016 18.2 0.0 2.1 8.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ResIII PF04851.13 NM_009503.4_3 - 0.0016 18.3 0.0 0.12 12.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.4 NM_009503.4_3 - 0.0021 18.1 0.1 3.4 7.6 0.0 2.9 3 0 0 3 3 2 1 Sigma-54 interaction domain PhoH PF02562.14 NM_009503.4_3 - 0.0024 17.2 0.5 2.3 7.5 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein TniB PF05621.9 NM_009503.4_3 - 0.0044 16.1 0.2 13 4.7 0.1 4.2 4 0 0 4 4 4 0 Bacterial TniB protein AAA_11 PF13086.4 NM_009503.4_3 - 0.0054 16.4 0.0 3 7.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.4 NM_009503.4_3 - 0.0056 16.9 0.4 3.7 7.7 0.2 3.1 2 1 1 3 3 2 0 AAA domain AAA_30 PF13604.4 NM_009503.4_3 - 0.038 13.6 0.4 3.9 7.0 0.1 2.6 2 0 0 2 2 2 0 AAA domain SKI PF01202.20 NM_009503.4_3 - 0.069 13.1 0.0 7.7 6.5 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase NTPase_1 PF03266.13 NM_009503.4_3 - 0.085 12.6 0.2 7 6.4 0.0 2.9 3 0 0 3 3 2 0 NTPase Cytidylate_kin PF02224.16 NM_009503.4_3 - 0.098 12.2 0.0 12 5.4 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase UFD1 PF03152.12 NM_009503.4_3 - 0.1 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 DUF3944 PF13099.4 NM_009503.4_3 - 0.13 12.0 0.0 0.41 10.4 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) Cnn_1N PF07989.9 NM_001289702.1_2 - 5.8e-23 80.7 8.1 5.8e-23 80.7 8.1 17.3 17 4 4 21 21 21 3 Centrosomin N-terminal motif 1 DUF1220 PF06758.11 NM_001289702.1_2 - 2.4e-14 53.3 2.1 1.1e-13 51.2 2.1 2.3 1 0 0 1 1 1 1 Repeat of unknown function (DUF1220) ATG16 PF08614.9 NM_001289702.1_2 - 0.00014 22.0 21.3 0.00014 22.0 21.3 15.0 8 3 5 13 13 13 3 Autophagy protein 16 (ATG16) PH PF00169.27 NM_001163183.1_3 - 7.4e-08 32.7 0.0 1.2e-07 32.1 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_001163183.1_3 - 3.8e-05 23.9 0.2 8.7e-05 22.8 0.2 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain Myelin_PLP PF01275.17 NM_001177960.1_1 - 2.3e-100 335.2 20.7 3e-100 334.8 20.7 1.1 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) DUF1777 PF08648.10 NM_001177960.1_1 - 0.0064 16.6 6.9 0.0086 16.2 6.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) DUF1777 PF08648.10 NM_001177960.1_2 - 0.0061 16.7 10.2 0.011 15.9 10.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) MIP-T3 PF10243.7 NM_001177960.1_2 - 0.43 9.1 6.8 0.59 8.6 6.8 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1777 PF08648.10 NM_001177960.1_3 - 0.0043 17.2 7.2 0.006 16.7 7.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) 6PF2K PF01591.16 NM_001177754.1_1 - 1.2e-106 354.9 0.2 1.7e-106 354.4 0.2 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 NM_001177754.1_1 - 1.5e-39 135.6 0.0 2.1e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 NM_001177754.1_1 - 7.7e-07 29.2 0.0 1.3e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 NM_001177754.1_1 - 8.9e-05 21.9 0.1 0.00014 21.2 0.1 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AA_permease_2 PF13520.4 NM_001301424.1_3 - 3.8e-48 164.2 25.3 3.8e-48 164.2 25.3 2.2 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.19 NM_001301424.1_3 - 3.8e-39 134.5 24.0 3.8e-39 134.5 24.0 2.0 2 0 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.4 NM_001301424.1_3 - 6.2e-26 90.1 7.7 3.5e-25 87.7 7.7 2.5 1 0 0 1 1 1 1 C-terminus of AA_permease NHL PF01436.19 NM_030706.3_1 - 2.9e-48 159.4 18.1 3e-09 36.3 0.2 6.6 6 0 0 6 6 6 6 NHL repeat DUF5128 PF17170.2 NM_030706.3_1 - 6.9e-17 61.5 8.9 1.7e-07 30.6 0.6 4.1 2 2 1 3 3 3 3 6-bladed beta-propeller Filamin PF00630.17 NM_030706.3_1 - 1.4e-16 61.0 0.0 3.1e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-B_box PF00643.22 NM_030706.3_1 - 3.1e-10 39.9 3.3 3.1e-10 39.9 3.3 3.4 3 0 0 3 3 2 1 B-box zinc finger SGL PF08450.10 NM_030706.3_1 - 4.7e-09 36.0 2.6 0.00051 19.6 0.1 4.5 2 2 3 5 5 5 2 SMP-30/Gluconolaconase/LRE-like region zf-RING_UBOX PF13445.4 NM_030706.3_1 - 2.3e-08 33.8 11.1 2.3e-08 33.8 11.1 3.1 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 NM_030706.3_1 - 2.1e-07 30.5 10.7 2.1e-07 30.5 10.7 4.0 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 NM_030706.3_1 - 2.4e-07 30.3 10.0 2.4e-07 30.3 10.0 4.0 5 0 0 5 5 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 NM_030706.3_1 - 6.7e-07 28.9 8.1 6.7e-07 28.9 8.1 3.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 NM_030706.3_1 - 1.4e-06 28.0 9.0 1.4e-06 28.0 9.0 3.9 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_030706.3_1 - 2e-06 27.8 9.7 2e-06 27.8 9.7 5.0 4 0 0 4 4 4 1 Ring finger domain Prok-RING_4 PF14447.4 NM_030706.3_1 - 2.4e-05 24.0 8.9 2.4e-05 24.0 8.9 3.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 DUF4934 PF16288.3 NM_030706.3_1 - 0.00012 21.8 1.0 0.24 11.2 0.2 2.9 2 1 1 3 3 3 2 Domain of unknown function (DUF4934) zf-C3HC4_4 PF15227.4 NM_030706.3_1 - 0.00097 19.1 11.5 0.00097 19.1 11.5 3.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Caskin-tail PF16632.3 NM_030706.3_1 - 0.046 14.0 0.7 0.092 13.0 0.7 1.5 1 0 0 1 1 1 0 C-terminal region of Caskin zf-ANAPC11 PF12861.5 NM_030706.3_1 - 0.084 12.8 3.9 0.063 13.2 1.4 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 NM_030706.3_1 - 0.16 11.6 7.0 0.37 10.4 4.4 2.9 2 0 0 2 2 2 0 RING-like zinc finger SBBP PF06739.9 NM_030706.3_1 - 0.17 11.8 1.2 1.9 8.5 0.4 2.5 2 0 0 2 2 2 0 Beta-propeller repeat Dzip-like_N PF13815.4 NM_030706.3_1 - 4.5 7.1 7.5 11 5.9 6.1 2.2 2 0 0 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal Tetraspannin PF00335.18 NM_001111049.1_1 - 8e-50 169.4 13.0 1.1e-49 169.0 13.0 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF4199 PF13858.4 NM_001111049.1_1 - 9.5e-06 26.0 1.1 1.9e-05 25.0 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) CD20 PF04103.13 NM_001111049.1_1 - 7.3e-05 22.8 7.6 0.00015 21.7 7.6 1.6 1 1 0 1 1 1 1 CD20-like family SUR7 PF06687.10 NM_001111049.1_1 - 0.0028 17.2 3.7 0.0054 16.3 3.7 1.4 1 0 0 1 1 1 1 SUR7/PalI family DUF2569 PF10754.7 NM_001111049.1_1 - 0.18 12.1 6.6 0.39 11.0 6.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) DUF373 PF04123.11 NM_001111049.1_1 - 1.6 8.0 5.1 2.8 7.2 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF308 PF03729.11 NM_001111049.1_1 - 2.4 8.4 17.3 0.36 11.0 7.4 2.6 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) Rubi_NSP_C PF12601.6 NM_001111049.1_2 - 0.046 13.7 0.3 0.19 11.7 0.2 2.0 2 0 0 2 2 2 0 Rubivirus non-structural protein SLC35F PF06027.10 NM_178675.4_2 - 1.9e-147 490.4 22.9 2.8e-147 489.9 22.9 1.2 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.18 NM_178675.4_2 - 1.9e-11 44.1 30.9 1.9e-06 28.0 13.1 2.5 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.8 NM_178675.4_2 - 1.8e-09 36.9 5.8 1.8e-09 36.9 5.8 1.6 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like DUF3915 PF13054.4 NM_178675.4_3 - 1.5 8.7 4.7 2.8 7.8 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Peptidase_S49_N PF08496.8 NM_178675.4_3 - 3 7.8 8.6 5.3 7.0 8.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PKI PF02827.14 NM_001039052.1_1 - 3.1e-25 88.0 0.5 3.1e-25 88.0 0.5 1.9 2 0 0 2 2 2 1 cAMP-dependent protein kinase inhibitor ABC2_membrane PF01061.22 NM_001286005.1_1 - 6.6e-34 117.0 14.0 6.6e-34 117.0 14.0 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.25 NM_001286005.1_1 - 7e-20 71.8 0.0 1.2e-19 71.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 NM_001286005.1_1 - 0.008 15.9 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system EF-hand_2 PF09068.9 NM_001314036.1_2 - 9.6e-41 138.6 1.3 1.7e-40 137.8 1.3 1.4 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.9 NM_001314036.1_2 - 2.4e-39 133.5 0.0 4.5e-39 132.6 0.0 1.5 1 0 0 1 1 1 1 EF-hand ZZ PF00569.15 NM_001314036.1_2 - 1.8e-19 69.2 4.2 4.8e-19 67.8 4.2 1.8 1 0 0 1 1 1 1 Zinc finger, ZZ type Miff PF05644.9 NM_001314036.1_2 - 0.0012 18.5 3.2 0.002 17.7 3.2 1.3 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff DUF972 PF06156.11 NM_001314036.1_2 - 0.0093 16.4 4.7 2.8 8.5 1.5 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF972) bZIP_1 PF00170.19 NM_001314036.1_2 - 0.12 12.4 8.2 1.7 8.6 0.8 2.6 2 0 0 2 2 2 0 bZIP transcription factor LRRFIP PF09738.7 NM_001314036.1_2 - 0.15 11.4 7.9 0.65 9.3 1.4 2.2 2 0 0 2 2 2 0 LRRFIP family SOGA PF11365.6 NM_001314036.1_2 - 0.27 12.3 9.7 1.3 10.1 1.9 2.5 1 1 1 2 2 2 0 Protein SOGA Nnf1 PF03980.12 NM_001314036.1_2 - 0.67 10.2 10.8 4 7.7 2.5 2.5 1 1 1 2 2 2 0 Nnf1 CEP63 PF17045.3 NM_001314036.1_2 - 0.74 9.5 8.7 4.9 6.8 0.9 2.4 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa IncA PF04156.12 NM_001314036.1_2 - 1.6 8.4 12.0 5.9 6.5 1.8 2.6 2 0 0 2 2 2 0 IncA protein Rootletin PF15035.4 NM_001314036.1_2 - 3.9 7.4 11.0 7.8 6.4 1.6 2.3 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion ERG2_Sigma1R PF04622.10 NM_001286551.1_1 - 2.8e-27 95.3 0.1 4.4e-27 94.7 0.1 1.2 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein DUF2810 PF10928.6 NM_001286551.1_2 - 0.055 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2810) ERG2_Sigma1R PF04622.10 NM_001286551.1_3 - 4.7e-18 65.2 0.1 6.9e-18 64.6 0.1 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein FA_FANCE PF11510.6 NM_001163819.1_1 - 1.5e-107 358.7 14.0 1.5e-107 358.7 14.0 1.5 2 0 0 2 2 2 1 Fanconi Anaemia group E protein FANCE Bystin PF05291.9 NM_001163819.1_1 - 2.2e-05 23.8 0.2 3.3e-05 23.2 0.2 1.1 1 0 0 1 1 1 1 Bystin DUF3944 PF13099.4 NM_001163819.1_1 - 0.14 11.9 0.9 0.31 10.8 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3944) UCH PF00443.27 NM_011669.3_1 - 1.1e-59 201.8 2.2 1.4e-59 201.5 2.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_011669.3_1 - 4.6e-33 115.0 2.2 6e-33 114.6 2.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SprT-like PF10263.7 NM_011669.3_1 - 0.11 12.2 0.7 0.21 11.3 0.7 1.4 1 0 0 1 1 1 0 SprT-like family zf-RING_6 PF14835.4 NM_011669.3_3 - 0.084 12.6 2.4 0.27 11.0 2.4 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Mre11_DNA_bind PF04152.12 NM_001310728.1_3 - 6.3e-29 101.3 4.5 4.8e-23 82.2 0.0 2.9 2 1 1 3 3 3 2 Mre11 DNA-binding presumed domain Metallophos PF00149.26 NM_001310728.1_3 - 3.6e-15 56.9 0.9 5.4e-15 56.3 0.9 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase GDA1_CD39 PF01150.15 NM_053103.5_3 - 1.3e-102 343.5 0.0 1.7e-102 343.1 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family PilX_N PF14341.4 NM_053103.5_3 - 0.14 12.0 1.0 0.35 10.7 1.0 1.7 1 0 0 1 1 1 0 PilX N-terminal BPS PF08947.8 NM_010345.4_2 - 1e-27 95.5 0.5 1.9e-27 94.7 0.5 1.4 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 NM_010345.4_2 - 1.6e-13 50.3 0.0 3.1e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 NM_010345.4_2 - 4.8e-10 39.8 1.7 6.9e-10 39.3 0.3 2.0 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 NM_010345.4_2 - 2.3e-08 34.4 0.1 4.4e-08 33.5 0.1 1.5 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.15 NM_009068.3_2 - 8.3e-51 172.6 0.0 1.2e-50 172.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_009068.3_2 - 3e-49 167.6 0.2 4.9e-49 166.9 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Death PF00531.20 NM_009068.3_2 - 2e-21 75.8 0.5 3.9e-21 74.9 0.5 1.5 1 0 0 1 1 1 1 Death domain RHIM PF12721.5 NM_009068.3_2 - 7.5e-07 29.4 0.3 2.9e-06 27.5 0.3 2.1 1 0 0 1 1 1 1 RIP homotypic interaction motif Kinase-like PF14531.4 NM_009068.3_2 - 0.00027 20.2 0.0 0.00045 19.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 NM_009068.3_2 - 0.034 13.4 0.1 0.065 12.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 NM_009068.3_2 - 0.077 12.4 0.4 0.14 11.6 0.4 1.3 1 0 0 1 1 1 0 RIO1 family Lectin_C PF00059.19 NM_001033122.3_1 - 5.1e-11 43.1 6.4 9.9e-11 42.2 6.4 1.5 1 0 0 1 1 1 1 Lectin C-type domain DUF1242 PF06842.10 NM_025335.3_1 - 3.3e-18 65.0 2.7 9.5e-18 63.6 2.7 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Tropomodulin PF03250.12 NM_016711.3_1 - 8.8e-58 194.2 5.2 1.3e-57 193.7 5.2 1.2 1 0 0 1 1 1 1 Tropomodulin LRR_6 PF13516.4 NM_016711.3_1 - 1.1 9.3 3.0 0.62 10.1 0.1 2.3 2 0 0 2 2 2 0 Leucine Rich repeat TMEM72 PF16054.3 NM_178768.4_2 - 3.1e-79 264.8 1.2 4.4e-79 264.3 1.2 1.2 1 0 0 1 1 1 1 Transmembrane protein family 72 Exo_endo_phos PF03372.21 NM_001195537.1_1 - 7.4e-05 22.8 0.0 0.00011 22.3 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Cadherin PF00028.15 NM_001098171.1_1 - 1e-82 272.6 0.1 2.4e-18 66.2 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_001098171.1_1 - 9.9e-35 118.1 0.2 2.1e-31 107.4 0.1 4.0 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 NM_001098171.1_1 - 1e-23 83.7 2.6 3.2e-23 82.2 0.5 2.9 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 NM_001098171.1_1 - 0.0093 15.8 1.0 3.5 7.5 0.0 4.3 5 0 0 5 5 5 1 Cadherin-like Tetraspannin PF00335.18 NM_173007.3_1 - 5.8e-34 117.6 11.9 5.8e-34 117.6 11.9 1.5 2 0 0 2 2 2 1 Tetraspanin family Herpes_LMP1 PF05297.9 NM_173007.3_1 - 0.76 8.8 10.2 1.2 8.1 10.2 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) NHR2 PF08788.9 NM_001290798.1_2 - 0.021 14.5 0.6 0.2 11.3 0.2 2.4 2 0 0 2 2 2 0 NHR2 domain like Ribosomal_L1 PF00687.19 NM_011287.2_3 - 1.7e-43 148.6 4.3 2.2e-43 148.2 4.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3671 PF12420.6 NM_011287.2_3 - 0.075 13.0 2.3 0.13 12.2 2.3 1.4 1 1 0 1 1 1 0 Protein of unknown function LRR_8 PF13855.4 NM_001113379.1_1 - 2.7e-63 209.5 59.9 9.1e-11 41.2 1.7 10.5 5 2 6 11 11 11 11 Leucine rich repeat LRR_4 PF12799.5 NM_001113379.1_1 - 6.2e-40 134.3 55.2 1.3e-06 28.4 1.4 12.5 9 3 4 13 13 13 11 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 NM_001113379.1_1 - 3.4e-15 54.0 53.1 1.2 9.8 1.2 19.3 18 2 2 20 20 20 4 Leucine Rich Repeat LRR_9 PF14580.4 NM_001113379.1_1 - 4.2e-07 29.5 14.6 0.012 15.0 0.2 5.6 3 2 3 6 6 6 4 Leucine-rich repeat LRR_6 PF13516.4 NM_001113379.1_1 - 1.9e-06 27.3 57.9 1.6 8.8 0.1 16.9 18 0 0 18 18 18 4 Leucine Rich repeat LRR_5 PF13306.4 NM_001113379.1_1 - 0.0011 18.9 0.0 0.028 14.2 0.0 2.6 3 0 0 3 3 3 1 Leucine rich repeats (6 copies) HTH_25 PF13413.4 NM_001113379.1_1 - 0.074 12.8 0.0 2.2 8.1 0.0 2.9 2 1 1 3 3 3 0 Helix-turn-helix domain PAG PF15347.4 NM_001195031.1_1 - 5e-203 674.8 12.8 6.2e-203 674.5 12.8 1.1 1 0 0 1 1 1 1 Phosphoprotein associated with glycosphingolipid-enriched Cadherin_C_2 PF16492.3 NM_001195031.1_1 - 0.0015 19.2 0.0 0.004 17.8 0.0 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal AAA PF00004.27 NM_001267847.1_1 - 2.6e-24 86.0 0.0 3.7e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 NM_001267847.1_1 - 4.9e-06 26.3 0.0 9.5e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.12 NM_001267847.1_1 - 0.002 18.0 0.0 0.0038 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 NM_001267847.1_1 - 0.0073 16.6 0.0 0.016 15.5 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 NM_001267847.1_1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.11 NM_001267847.1_1 - 0.14 10.9 0.0 0.22 10.3 0.0 1.1 1 0 0 1 1 1 0 TIP49 C-terminus IspD PF01128.17 NM_001289503.1_3 - 1.1e-24 87.3 0.0 1.7e-24 86.7 0.0 1.2 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Pecanex_C PF05041.13 NM_144868.3_1 - 5e-113 376.1 0.0 6.8e-113 375.7 0.0 1.2 1 0 0 1 1 1 1 Pecanex protein (C-terminus) LRR_8 PF13855.4 NM_025817.4_3 - 5.9e-63 208.4 42.5 6.1e-18 64.2 2.3 5.5 3 1 3 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 NM_025817.4_3 - 2.7e-17 62.4 31.5 0.00013 22.2 0.5 6.8 6 1 1 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_025817.4_3 - 1.2e-10 41.1 1.1 0.013 14.9 0.1 4.2 1 1 5 6 6 6 6 Leucine-rich repeat LRR_1 PF00560.31 NM_025817.4_3 - 9.8e-07 28.3 31.7 0.71 10.4 0.1 11.7 10 1 0 10 10 10 2 Leucine Rich Repeat LRR_5 PF13306.4 NM_025817.4_3 - 1.3e-06 28.2 0.0 1.1 9.1 0.0 3.2 1 1 0 3 3 3 3 Leucine rich repeats (6 copies) LRRCT PF01463.22 NM_025817.4_3 - 3.6e-05 23.9 0.2 0.00019 21.6 0.2 2.4 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain fn3 PF00041.19 NM_025817.4_3 - 0.12 12.7 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III domain CopD PF05425.11 NM_025817.4_3 - 0.13 12.5 1.8 0.27 11.5 1.8 1.4 1 0 0 1 1 1 0 Copper resistance protein D Bromodomain PF00439.23 NM_172836.3_1 - 5.9e-05 22.9 0.2 0.00029 20.7 0.0 2.1 2 0 0 2 2 2 1 Bromodomain NEXCaM_BD PF16644.3 NM_172836.3_1 - 0.53 10.4 7.5 1.8 8.7 7.5 2.0 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Pacs-1 PF10254.7 NM_153129.2_1 - 1.5e-188 626.8 0.0 1.5e-188 626.8 0.0 2.3 3 0 0 3 3 3 1 PACS-1 cytosolic sorting protein Urotensin_II PF02083.13 NM_001278788.1_1 - 0.0054 16.2 3.2 0.018 14.5 3.2 1.9 1 0 0 1 1 1 1 Urotensin II 7tm_4 PF13853.4 NM_001278788.1_2 - 1.3e-51 175.8 21.3 1.6e-51 175.6 21.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001278788.1_2 - 1.7e-18 66.7 27.3 3.9e-18 65.5 26.2 2.1 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF456 PF04306.11 NM_001278788.1_2 - 0.0082 16.3 4.4 0.015 15.5 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF456) SLC3A2_N PF16028.3 NM_001278788.1_2 - 4.8 6.7 6.7 6.7 6.2 0.5 3.2 4 0 0 4 4 4 0 Solute carrier family 3 member 2 N-terminus MRAP PF15183.4 NM_029844.3_1 - 1.5e-43 146.5 0.1 2.2e-43 146.0 0.1 1.2 1 0 0 1 1 1 1 Melanocortin-2 receptor accessory protein family EF-hand_6 PF13405.4 NM_172259.1_3 - 4e-10 38.7 0.3 0.00015 21.3 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 NM_172259.1_3 - 2.9e-09 35.7 0.3 0.011 15.1 0.1 3.6 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.4 NM_172259.1_3 - 5.2e-07 29.9 0.1 0.0033 17.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.4 NM_172259.1_3 - 0.00015 21.9 0.0 0.038 14.2 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 NM_172259.1_3 - 0.00023 20.7 1.8 1.4 8.6 0.0 3.6 2 1 1 3 3 3 2 EF-hand domain pair Lipocalin PF00061.21 NM_010695.1_1 - 6.8e-18 65.1 0.0 8.3e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family DUF4972 PF16342.3 NM_010695.1_1 - 0.15 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4972) MHC_I PF00129.16 NM_153760.2_3 - 2.7e-32 111.6 0.0 3.8e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_3 PF16497.3 NM_153760.2_3 - 9.6e-13 47.9 0.0 2.1e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 NM_153760.2_3 - 6.8e-08 32.7 0.3 2e-07 31.2 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 NM_153760.2_3 - 0.0072 16.8 0.8 0.035 14.6 0.0 2.5 2 1 1 3 3 3 1 Immunoglobulin domain BiPBP_C PF06832.10 NM_153760.2_3 - 0.028 14.3 0.2 0.42 10.6 0.0 2.6 3 0 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family C2-set_2 PF08205.10 NM_153760.2_3 - 0.16 12.0 2.3 0.27 11.2 0.0 2.4 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain MBD PF01429.17 NM_054078.2_3 - 3.7e-20 71.3 0.4 8.9e-20 70.1 0.4 1.7 1 0 0 1 1 1 1 Methyl-CpG binding domain Bromodomain PF00439.23 NM_054078.2_3 - 1.8e-19 69.5 0.0 3.9e-19 68.4 0.0 1.5 1 0 0 1 1 1 1 Bromodomain WSD PF15613.4 NM_054078.2_3 - 9.8e-13 48.3 12.1 4.6e-07 30.1 0.0 3.8 4 0 0 4 4 4 2 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD PF00628.27 NM_054078.2_3 - 1.7e-10 40.4 8.9 4e-10 39.3 8.9 1.7 1 0 0 1 1 1 1 PHD-finger DDT PF02791.15 NM_054078.2_3 - 2.2e-09 37.4 0.8 7.6e-09 35.6 0.8 2.1 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.4 NM_054078.2_3 - 5.6e-06 25.6 0.0 1.4e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 CUB PF00431.18 NM_001077405.1_1 - 2.9e-57 191.6 0.0 3.3e-28 98.1 0.0 2.6 2 0 0 2 2 2 2 CUB domain F5_F8_type_C PF00754.23 NM_001077405.1_1 - 3.1e-56 188.8 0.4 1.4e-28 99.4 0.0 2.4 2 0 0 2 2 2 2 F5/8 type C domain DUF3481 PF11980.6 NM_001077405.1_1 - 7.9e-39 131.1 0.6 7.9e-39 131.1 0.6 2.6 3 0 0 3 3 3 1 C-terminal domain of neuropilin glycoprotein MAM PF00629.21 NM_001077405.1_1 - 3.9e-29 101.4 0.0 7e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu 7tm_1 PF00001.19 NM_007721.4_3 - 1.3e-41 142.5 0.0 3.5e-41 141.1 0.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cor1 PF04803.10 NM_001126317.1_1 - 5.1e-35 120.4 21.6 9.2e-35 119.6 21.6 1.4 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region DUF3198 PF11433.6 NM_001126317.1_1 - 2.1 8.2 8.1 0.5 10.1 4.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3198) DUF922 PF06037.9 NM_001126317.1_1 - 8.3 6.0 12.2 7 6.3 3.2 2.8 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF922) Granulin PF00396.16 NM_008175.4_2 - 6.3e-93 304.8 240.4 6.4e-16 58.3 21.5 12.7 12 3 3 15 15 15 10 Granulin Lustrin_cystein PF14625.4 NM_008175.4_2 - 0.0057 16.9 19.2 0.0078 16.5 4.3 15.7 13 2 2 15 15 15 3 Lustrin, cysteine-rich repeated domain GDNF PF02351.14 NM_001271002.1_1 - 4.8e-34 117.1 17.0 1.5e-22 80.2 3.2 2.3 2 0 0 2 2 2 2 GDNF/GAS1 domain Mob1_phocein PF03637.15 NM_172457.2_1 - 4e-81 270.8 0.0 5.7e-81 270.4 0.0 1.2 1 0 0 1 1 1 1 Mob1/phocein family SNF2_N PF00176.21 NM_001081221.1_3 - 4.2e-74 249.2 0.1 2.8e-73 246.5 0.0 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.29 NM_001081221.1_3 - 1.1e-17 64.3 0.0 3.3e-17 62.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 NM_001081221.1_3 - 0.039 13.8 0.0 0.039 13.8 0.0 3.2 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit DUF342 PF03961.11 NM_001081221.1_3 - 0.22 9.9 2.7 0.48 8.8 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) fn3 PF00041.19 NM_001290315.1_2 - 8.6e-65 215.0 11.2 9.2e-16 57.8 0.4 5.5 5 0 0 5 5 5 5 Fibronectin type III domain Ig_3 PF13927.4 NM_001290315.1_2 - 3.3e-48 162.1 0.1 4.5e-13 49.5 0.0 5.1 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 NM_001290315.1_2 - 1.5e-47 159.5 0.0 6e-15 55.0 0.0 5.2 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_001290315.1_2 - 1.1e-27 96.0 0.0 1.4e-06 28.4 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 NM_001290315.1_2 - 7.2e-26 90.0 0.0 7.2e-06 25.9 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 NM_001290315.1_2 - 1.4e-22 79.9 1.3 4.9e-06 26.9 0.0 5.5 5 0 0 5 5 5 4 Purple acid Phosphatase, N-terminal domain V-set PF07686.15 NM_001290315.1_2 - 4.1e-17 62.2 0.5 0.0019 18.2 0.0 7.4 6 2 1 7 7 7 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001290315.1_2 - 7.6e-08 32.2 0.3 4.1 7.4 0.0 4.7 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 NM_001290315.1_2 - 0.031 14.2 0.0 17 5.4 0.0 3.0 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Cadherin PF00028.15 NM_001290315.1_2 - 0.033 14.5 0.0 2.5 8.5 0.0 2.5 2 0 0 2 2 2 0 Cadherin domain V1R PF03402.12 NM_207546.2_2 - 1.7e-12 47.4 15.8 3.2e-12 46.5 15.8 1.4 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_207546.2_2 - 2.9e-10 39.6 17.7 4.1e-10 39.1 17.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_207546.2_2 - 4e-06 26.1 16.8 4.5e-06 26.0 16.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pkinase_Tyr PF07714.15 NM_001163216.2_2 - 1.1e-102 342.7 0.0 1.5e-102 342.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001163216.2_2 - 5.6e-44 150.4 0.0 7.6e-44 149.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 NM_001163216.2_2 - 5e-35 119.3 0.0 3.1e-15 55.9 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001163216.2_2 - 3.9e-34 117.0 0.0 2.2e-12 47.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 NM_001163216.2_2 - 3.5e-24 84.8 0.0 1e-09 38.5 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 NM_001163216.2_2 - 2e-22 79.0 0.1 3.5e-08 33.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 NM_001163216.2_2 - 5.4e-12 45.7 1.1 0.0015 18.5 0.0 5.3 3 3 1 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001163216.2_2 - 0.00027 20.8 0.1 0.046 13.7 0.0 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 NM_001163216.2_2 - 0.021 14.7 0.0 28 4.7 0.0 3.4 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Peptidase_M14 PF00246.22 NM_030231.3_1 - 1.3e-25 90.7 0.0 5.5e-25 88.6 0.0 1.9 1 1 0 1 1 1 1 Zinc carboxypeptidase Vezatin PF12632.5 NM_172538.5_2 - 1e-90 303.8 4.2 1e-90 303.8 4.2 1.9 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes FYVE_2 PF02318.14 NM_001291159.1_1 - 5.2e-18 65.3 0.3 1e-17 64.3 0.3 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger Ras PF00071.20 NM_001293654.1_1 - 4.7e-57 192.0 0.1 6.5e-57 191.5 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_001293654.1_1 - 3e-31 108.0 0.0 5.2e-31 107.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_001293654.1_1 - 2.2e-12 46.7 0.0 3.5e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_001293654.1_1 - 1.9e-06 27.8 0.0 3.3e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 NM_001293654.1_1 - 5.2e-05 22.6 0.0 8.1e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 NM_001293654.1_1 - 5.3e-05 23.0 0.0 0.011 15.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_001293654.1_1 - 0.00071 19.0 0.0 0.014 14.8 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Septin PF00735.16 NM_001293654.1_1 - 0.037 13.1 0.2 0.11 11.5 0.1 1.8 2 0 0 2 2 2 0 Septin cobW PF02492.17 NM_001293654.1_1 - 0.038 13.4 0.0 0.08 12.4 0.0 1.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.4 NM_001293654.1_1 - 0.045 13.9 0.0 0.093 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 NM_001293654.1_1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.7 NM_001293654.1_1 - 0.12 12.0 0.1 0.59 9.7 0.1 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.8 NM_001293654.1_1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.4 NM_001293654.1_1 - 0.12 12.6 0.0 0.27 11.5 0.0 1.5 2 0 0 2 2 1 0 AAA ATPase domain Gastrin PF00918.15 NM_031161.4_1 - 2.5e-38 131.7 0.0 3.5e-38 131.3 0.0 1.2 1 0 0 1 1 1 1 Gastrin/cholecystokinin family Endosulfine PF04667.15 NM_001142655.1_3 - 7.6e-09 35.5 1.4 1.2e-08 34.8 1.4 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region DEAD PF00270.27 NM_001190786.1_2 - 1.3e-27 96.6 0.0 1.9e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 NM_001190786.1_2 - 1.1e-25 90.1 0.0 1.9e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 NM_001291432.1_2 - 4.5e-11 42.3 8.0 4.5e-11 42.3 8.0 2.3 3 0 0 3 3 3 1 PHD-finger Xpo1 PF08389.10 NM_028198.2_1 - 3.6e-32 111.4 8.8 5.1e-32 110.9 6.6 2.4 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.17 NM_028198.2_1 - 0.00024 20.8 0.0 0.00081 19.1 0.0 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain IMD PF08397.9 NM_028198.2_1 - 0.048 12.9 0.6 0.14 11.4 0.6 1.7 1 0 0 1 1 1 0 IRSp53/MIM homology domain UCH PF00443.27 NM_028198.2_1 - 0.26 10.6 0.6 0.79 9.0 0.6 1.8 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase CTNNB1_binding PF08347.9 NM_001313981.1_1 - 3.1e-29 102.5 1.7 3.1e-29 102.5 1.7 1.9 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 NM_001313981.1_1 - 1.8e-21 76.2 1.1 1.8e-21 76.2 1.1 2.2 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.8 NM_001313981.1_1 - 4.7e-08 33.4 1.3 9.9e-08 32.3 1.3 1.5 1 0 0 1 1 1 1 HMG-box domain EF1G PF00647.17 NM_026007.4_3 - 3e-53 178.3 0.3 5.3e-53 177.5 0.3 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.18 NM_026007.4_3 - 4.2e-23 81.3 0.0 8.9e-23 80.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 NM_026007.4_3 - 1.1e-19 70.2 1.9 2.5e-19 69.2 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 NM_026007.4_3 - 1.1e-09 38.0 0.0 3.5e-09 36.3 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_026007.4_3 - 4.9e-07 29.7 0.3 1.5e-06 28.2 0.0 2.0 2 1 1 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 NM_026007.4_3 - 2.3e-06 27.7 0.0 5.1e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 NM_026007.4_3 - 0.0017 18.5 0.0 0.004 17.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain SAPS PF04499.13 NM_026007.4_3 - 0.22 10.1 0.2 0.29 9.8 0.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NUC194 PF08163.10 NM_026007.4_3 - 0.24 10.4 1.1 0.67 9.0 0.3 1.8 2 0 0 2 2 2 0 NUC194 domain Pkinase PF00069.23 NM_001003920.3_3 - 5.2e-73 245.5 0.0 6.7e-73 245.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001003920.3_3 - 6e-39 133.8 0.0 8e-39 133.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 NM_001003920.3_3 - 0.00011 22.0 0.0 0.0031 17.4 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.4 NM_001003920.3_3 - 0.018 14.2 0.0 0.027 13.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.18 NM_001003920.3_3 - 0.02 14.4 0.1 0.035 13.5 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.12 NM_001003920.3_3 - 0.027 13.7 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family cIII PF08134.9 NM_001003920.3_3 - 0.14 11.8 0.1 0.47 10.1 0.1 1.9 1 0 0 1 1 1 0 cIII protein family Hydrolase_4 PF12146.6 NM_001166250.1_1 - 6.3e-08 32.0 0.3 9e-08 31.5 0.3 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Taxilin PF09728.7 NM_001290777.1_1 - 3.4e-53 180.8 23.8 4.4e-53 180.4 23.8 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein HOOK PF05622.10 NM_001290777.1_1 - 0.43 8.5 24.8 0.53 8.2 23.3 1.6 1 1 1 2 2 2 0 HOOK protein Cas_DxTHG PF09455.8 NM_001290777.1_1 - 1.9 7.9 9.7 2.6 7.4 9.7 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family APG6 PF04111.10 NM_001290777.1_1 - 2 7.6 23.2 2.9 7.1 23.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 7tm_4 PF13853.4 NM_146451.1_1 - 6.2e-49 167.1 20.8 8.1e-49 166.7 20.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146451.1_1 - 9.2e-24 84.0 19.9 1.7e-23 83.1 19.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146451.1_1 - 3.1e-07 29.9 22.2 5.6e-07 29.1 22.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SSF PF00474.15 NM_133254.3_1 - 1.6e-167 557.4 19.1 2e-167 557.0 19.1 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family C2 PF00168.28 NM_011286.3_1 - 2.2e-48 162.6 0.0 7.5e-24 83.9 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 NM_011286.3_1 - 3.1e-36 124.0 6.8 6.5e-36 123.0 6.8 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger PI3K_C2 PF00792.22 NM_011286.3_1 - 0.0053 16.7 0.0 0.54 10.2 0.0 2.4 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 zf-piccolo PF05715.11 NM_011286.3_1 - 0.0057 16.6 12.6 0.018 15.0 12.6 1.9 1 0 0 1 1 1 1 Piccolo Zn-finger C1_1 PF00130.20 NM_011286.3_1 - 1.1 9.1 9.0 2.8 7.8 9.0 1.7 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Draxin PF15550.4 NM_027426.3_1 - 2.5e-133 444.7 5.1 3.7e-133 444.2 5.1 1.2 1 0 0 1 1 1 1 Draxin Aminotran_1_2 PF00155.19 NM_009653.3_1 - 1.2e-76 258.1 0.0 1.5e-76 257.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Preseq_ALAS PF09029.8 NM_009653.3_1 - 2e-11 44.3 1.0 1.9e-07 31.4 0.4 2.7 1 1 1 2 2 2 2 5-aminolevulinate synthase presequence Aminotran_5 PF00266.17 NM_009653.3_1 - 5.5e-09 35.3 0.0 9.1e-09 34.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.18 NM_009653.3_1 - 5.6e-06 25.0 0.0 1.1e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.15 NM_009653.3_1 - 0.0082 15.4 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Mustang PF15682.3 NM_009653.3_1 - 0.17 11.8 0.0 0.49 10.4 0.0 1.8 1 1 0 1 1 1 0 Musculoskeletal, temporally activated-embryonic nuclear protein 1 BIR PF00653.19 NM_001163247.1_2 - 3.9e-21 75.4 0.3 1e-20 74.1 0.3 1.8 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.4 NM_001163247.1_2 - 5e-10 38.9 15.6 5e-10 38.9 15.6 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 NM_001163247.1_2 - 7.2e-07 28.8 21.1 0.0003 20.4 16.0 2.5 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 NM_001163247.1_2 - 3.3e-05 23.6 8.7 3.3e-05 23.6 8.7 2.9 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.4 NM_001163247.1_2 - 6.5e-05 23.0 18.5 0.0034 17.5 10.3 3.0 3 0 0 3 3 3 2 Ring finger domain DUF2039 PF10217.7 NM_001163247.1_2 - 0.0012 19.0 3.0 0.002 18.3 3.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) zf-C3HC4_2 PF13923.4 NM_001163247.1_2 - 0.0018 17.9 16.6 0.01 15.6 10.0 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_001163247.1_2 - 0.0023 17.6 14.9 0.006 16.3 9.0 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_001163247.1_2 - 0.028 14.3 4.2 0.028 14.3 4.2 3.5 3 0 0 3 3 3 0 RING-type zinc-finger ArfGap PF01412.16 NM_001163247.1_2 - 0.044 13.7 0.9 0.073 13.0 0.9 1.3 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf Mito_carr PF00153.25 NM_001252394.1_2 - 2.3e-20 72.2 0.0 3.6e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial carrier protein Mito_carr PF00153.25 NM_001252394.1_3 - 1.3e-26 92.2 0.1 2e-17 62.8 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein Sugar_tr PF00083.22 NM_145559.2_3 - 3.8e-72 243.5 23.6 3.7e-38 131.4 8.0 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 NM_145559.2_3 - 4.2e-17 62.0 29.5 1.7e-08 33.6 11.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily C2 PF00168.28 NM_053270.1_1 - 1.8e-38 130.8 0.0 1.4e-18 66.9 0.1 2.7 2 0 0 2 2 2 2 C2 domain PDZ PF00595.22 NM_053270.1_1 - 5.1e-10 39.4 0.0 1.1e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FYVE_2 PF02318.14 NM_053270.1_1 - 1.2e-09 38.3 12.2 5.5e-07 29.7 7.7 2.8 2 0 0 2 2 2 2 FYVE-type zinc finger Nudix_N_2 PF14803.4 NM_053270.1_1 - 0.011 15.5 1.0 0.044 13.6 1.0 2.2 1 0 0 1 1 1 0 Nudix N-terminal zf-piccolo PF05715.11 NM_053270.1_1 - 7.5 6.7 10.5 18 5.5 10.5 1.7 1 0 0 1 1 1 0 Piccolo Zn-finger FYVE PF01363.19 NM_053270.1_1 - 7.7 6.6 12.7 19 5.3 12.7 1.6 1 0 0 1 1 1 0 FYVE zinc finger Ribosomal_L22 PF00237.17 NM_001002239.3_3 - 1.5e-42 144.0 0.1 2.5e-42 143.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e TB2_DP1_HVA22 PF03134.17 NM_180588.2_1 - 1e-27 95.7 10.1 2.2e-27 94.6 10.1 1.6 1 0 0 1 1 1 1 TB2/DP1, HVA22 family FlgD PF03963.12 NM_180588.2_1 - 0.0031 17.6 0.2 0.007 16.5 0.2 1.6 1 0 0 1 1 1 1 Flagellar hook capping protein - N-terminal region DUF2306 PF10067.7 NM_180588.2_1 - 0.55 10.3 8.4 0.051 13.7 3.6 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2306) Nodulin PF02451.13 NM_180588.2_3 - 4.7 6.5 10.1 0.57 9.5 5.5 1.8 2 0 0 2 2 2 0 Nodulin GDNF PF02351.14 NM_001136063.2_1 - 4.6e-34 117.1 17.0 1.6e-22 80.1 3.2 2.4 2 0 0 2 2 2 2 GDNF/GAS1 domain CD225 PF04505.10 NM_001136063.2_2 - 0.16 12.0 1.6 0.39 10.8 1.6 1.6 1 0 0 1 1 1 0 Interferon-induced transmembrane protein Fox-1_C PF12414.6 NM_001136063.2_3 - 0.12 12.5 1.3 0.32 11.2 1.3 1.6 1 0 0 1 1 1 0 Calcitonin gene-related peptide regulator C terminal NIF PF03031.16 NM_001290991.1_3 - 1.5e-54 183.8 1.0 2.4e-54 183.2 1.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Ribosomal_L27A PF00828.17 NM_025300.4_2 - 4.5e-27 95.0 0.0 6.2e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A CAML PF14963.4 NM_007596.2_3 - 1.7e-138 461.1 0.0 2e-138 460.9 0.0 1.0 1 0 0 1 1 1 1 Calcium signal-modulating cyclophilin ligand ERGIC_N PF13850.4 NM_007596.2_3 - 0.09 13.0 0.1 0.65 10.3 0.0 2.1 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Galactosyl_T PF01762.19 NM_001169114.1_3 - 2e-40 138.6 0.0 2.6e-40 138.2 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 NM_001169114.1_3 - 0.01 15.2 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Fringe-like DUF604 PF04646.10 NM_001169114.1_3 - 0.033 13.4 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF604 Cpn60_TCP1 PF00118.22 NM_001286981.1_1 - 8.6e-87 291.7 0.0 2e-46 158.5 0.0 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family IFT43 PF15305.4 NM_029601.3_3 - 1.4e-48 164.4 2.4 1.4e-48 164.4 2.4 1.6 2 0 0 2 2 2 1 Intraflagellar transport protein 43 BTB_2 PF02214.20 NM_026214.3_2 - 1.9e-17 63.2 0.0 3.8e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Lipase PF00151.17 NM_001252513.1_1 - 1.4e-80 271.0 0.0 1.8e-80 270.6 0.0 1.1 1 0 0 1 1 1 1 Lipase WSC PF01822.17 NM_177618.4_2 - 3.3e-30 104.0 18.3 3.3e-18 65.5 8.9 2.7 2 0 0 2 2 2 2 WSC domain Sulfotransfer_1 PF00685.25 NM_177618.4_2 - 1.9e-06 27.4 0.1 3.9e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 Sulfotransferase domain HIN PF02760.13 NM_001033450.4_2 - 2.9e-73 244.9 1.2 4.2e-73 244.4 1.2 1.2 1 0 0 1 1 1 1 HIN-200/IF120x domain PYRIN PF02758.14 NM_001033450.4_2 - 1.6e-08 34.5 1.4 1.9e-08 34.2 0.1 1.9 2 0 0 2 2 2 1 PAAD/DAPIN/Pyrin domain Agouti PF05039.10 NM_001033450.4_2 - 0.071 13.7 2.8 0.2 12.2 2.8 1.8 1 0 0 1 1 1 0 Agouti protein DUF4551 PF15087.4 NM_001033450.4_2 - 3.3 6.3 9.3 4.6 5.8 9.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Mago_nashi PF02792.12 NM_001282737.1_2 - 1.1e-79 265.3 0.2 1.3e-79 265.1 0.2 1.1 1 0 0 1 1 1 1 Mago nashi protein DUF3498 PF12004.6 NM_001281491.1_1 - 8.5e-184 612.4 10.9 8.5e-184 612.4 10.9 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3498) RasGAP PF00616.17 NM_001281491.1_1 - 1.6e-27 96.5 4.8 5e-15 55.6 0.0 3.2 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.28 NM_001281491.1_1 - 3.9e-08 33.4 0.0 8.9e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 C2 domain PH PF00169.27 NM_001281491.1_1 - 7e-05 23.2 0.1 0.055 13.9 0.1 2.7 2 0 0 2 2 2 2 PH domain PH_2 PF08458.8 NM_001281491.1_1 - 0.026 14.7 0.0 0.053 13.7 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Exonuc_VII_L PF02601.13 NM_001281491.1_1 - 0.032 13.7 6.1 0.06 12.8 6.1 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit PH_6 PF15406.4 NM_001281491.1_1 - 0.11 12.7 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain Spc7 PF08317.9 NM_001281491.1_1 - 2.7 6.6 15.1 6.6 5.4 15.0 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein IncA PF04156.12 NM_001281491.1_1 - 2.8 7.5 10.9 7.2 6.2 10.9 1.6 1 0 0 1 1 1 0 IncA protein V_ATPase_I PF01496.17 NM_001281491.1_1 - 3.6 5.2 6.6 5.3 4.7 6.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tropomyosin_1 PF12718.5 NM_001281491.1_1 - 3.6 7.6 17.7 2.1 8.3 1.9 2.4 1 1 1 2 2 2 0 Tropomyosin like APP_E2 PF12925.5 NM_001102455.1_2 - 1.7e-68 229.9 16.7 2e-68 229.7 15.6 1.7 2 0 0 2 2 2 1 E2 domain of amyloid precursor protein APP_N PF02177.14 NM_001102455.1_2 - 2.5e-40 136.7 0.5 2.5e-40 136.7 0.5 1.9 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding APP_amyloid PF10515.7 NM_001102455.1_2 - 3.9e-25 88.0 0.2 1.7e-24 86.0 0.2 2.2 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus APP_Cu_bd PF12924.5 NM_001102455.1_2 - 3.6e-23 81.9 4.6 3.6e-23 81.9 4.6 2.4 3 0 0 3 3 3 1 Copper-binding of amyloid precursor, CuBD Kunitz_BPTI PF00014.21 NM_001102455.1_2 - 1.4e-19 69.9 4.2 1.4e-19 69.9 4.2 2.2 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Activator-TraM PF11657.6 NM_001102455.1_2 - 3.8 7.2 6.0 7.3 6.3 6.0 1.4 1 0 0 1 1 1 0 Transcriptional activator TraM Interferon PF00143.17 NM_001098841.3_2 - 4.9e-26 91.7 0.0 7.6e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Interferon alpha/beta domain 7tm_4 PF13853.4 NM_001011794.1_1 - 3.9e-51 174.3 19.2 4.8e-51 174.0 19.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011794.1_1 - 1.5e-18 66.9 25.0 3.7e-18 65.6 25.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Hormone_1 PF00103.18 NM_031191.1_2 - 2.5e-73 246.3 1.8 2.9e-73 246.0 1.8 1.0 1 0 0 1 1 1 1 Somatotropin hormone family PMC2NT PF08066.10 NM_031191.1_2 - 0.14 12.7 0.3 0.26 11.8 0.3 1.5 1 0 0 1 1 1 0 PMC2NT (NUC016) domain Pkinase PF00069.23 NM_001291037.1_1 - 2.9e-58 197.2 0.0 3.9e-58 196.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001291037.1_1 - 7e-28 97.5 0.0 1.1e-27 96.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_001291037.1_1 - 0.00024 20.4 0.1 0.00046 19.5 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_001291037.1_1 - 0.02 14.1 0.0 0.033 13.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.21 NM_001291037.1_1 - 0.065 13.0 0.0 0.065 13.0 0.0 2.6 2 1 0 2 2 2 0 Phosphotransferase enzyme family F-box PF00646.31 NM_025386.3_3 - 1.1e-07 31.4 1.3 2e-07 30.6 1.3 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 NM_025386.3_3 - 1.4e-06 27.9 1.2 3.5e-06 26.7 1.2 1.8 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.3 NM_025386.3_3 - 0.012 15.4 0.1 0.023 14.5 0.1 1.5 1 0 0 1 1 1 0 F-box 7tm_1 PF00001.19 NM_009218.3_2 - 5.3e-57 193.0 17.5 7.7e-57 192.4 17.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_009218.3_2 - 5.8e-12 45.4 8.7 7.4e-12 45.1 8.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_009218.3_2 - 3.2e-05 23.2 6.1 4.5e-05 22.8 6.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 NM_009218.3_2 - 0.00034 19.9 2.8 0.00034 19.9 2.8 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 NM_009218.3_2 - 0.0075 15.9 3.8 0.016 14.8 3.8 1.5 1 1 0 1 1 1 1 Olfactory receptor Serpentine_r_xa PF03383.13 NM_009218.3_2 - 2.7 7.8 5.8 0.34 10.8 0.1 2.1 2 0 0 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa Spin-Ssty PF02513.15 NM_001160131.1_3 - 1.1e-57 191.4 10.5 3e-22 77.9 0.1 3.3 3 0 0 3 3 3 3 Spin/Ssty Family RRM_1 PF00076.20 NM_178660.4_2 - 3.6e-30 103.5 0.0 1.7e-15 56.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PARP PF00644.18 NM_009632.2_3 - 3e-74 249.0 0.0 6.8e-74 247.8 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.12 NM_009632.2_3 - 2.7e-47 160.1 0.1 5.4e-47 159.1 0.1 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.13 NM_009632.2_3 - 1.1e-27 95.7 1.9 1.1e-27 95.7 1.9 2.0 2 0 0 2 2 2 1 WGR domain Trypsin_2 PF13365.4 NM_001081187.3_2 - 1.7e-31 110.0 0.1 3.7e-31 108.9 0.1 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.24 NM_001081187.3_2 - 8.4e-13 48.5 0.0 1.3e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin IGFBP PF00219.16 NM_001081187.3_2 - 3.4e-10 40.3 22.7 3.4e-10 40.3 22.7 1.8 2 0 0 2 2 2 1 Insulin-like growth factor binding protein PDZ_2 PF13180.4 NM_001081187.3_2 - 4.3e-09 36.4 0.0 9.7e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.22 NM_001081187.3_2 - 7.8e-08 32.4 0.1 1.6e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Kazal_2 PF07648.13 NM_001081187.3_2 - 4.7e-07 29.8 0.5 1.1e-06 28.6 0.5 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Peptidase_S46 PF10459.7 NM_001081187.3_2 - 2.9e-05 22.8 0.7 0.07 11.6 0.0 2.1 2 0 0 2 2 2 2 Peptidase S46 Peptidase_S32 PF05579.11 NM_001081187.3_2 - 0.0028 16.8 0.1 2 7.4 0.2 2.2 2 0 0 2 2 2 2 Equine arteritis virus serine endopeptidase S32 Kazal_1 PF00050.19 NM_001081187.3_2 - 0.0037 17.1 0.1 0.012 15.4 0.1 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain LSM PF01423.20 NM_001081187.3_2 - 0.054 13.1 0.2 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 LSM domain PDZ_1 PF12812.5 NM_001081187.3_2 - 0.093 12.7 0.3 0.26 11.3 0.1 1.8 2 0 0 2 2 2 0 PDZ-like domain V1R PF03402.12 NM_053235.2_1 - 1.8e-56 191.6 22.4 2.2e-56 191.3 22.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 NM_053235.2_1 - 0.00019 20.6 23.3 0.00027 20.1 23.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) H_PPase PF03030.14 NM_053235.2_1 - 0.02 13.4 8.8 0.025 13.1 8.8 1.3 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase TctB PF07331.9 NM_053235.2_1 - 0.027 14.6 1.3 0.027 14.6 1.3 2.9 1 1 2 3 3 3 0 Tripartite tricarboxylate transporter TctB family I-set PF07679.14 NM_019413.2_2 - 1.2e-89 294.3 0.0 3.3e-23 81.4 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_019413.2_2 - 2.3e-83 274.7 0.5 1.6e-16 60.5 0.1 6.2 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 NM_019413.2_2 - 1.8e-51 172.3 0.1 1.1e-09 38.4 0.0 6.1 6 0 0 6 6 6 5 Immunoglobulin domain ig PF00047.23 NM_019413.2_2 - 1.2e-47 159.9 0.0 5.8e-10 39.1 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.19 NM_019413.2_2 - 1.5e-34 118.1 8.5 5.8e-12 45.7 0.4 3.8 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.15 NM_019413.2_2 - 4.8e-27 94.1 8.7 2.7e-09 37.0 0.1 9.1 6 4 0 6 6 6 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_019413.2_2 - 3.2e-17 62.3 0.6 0.022 14.7 0.0 6.3 6 0 0 6 6 6 5 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 NM_019413.2_2 - 5.7e-08 33.0 0.0 1.9 8.8 0.0 5.2 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pur_ac_phosph_N PF16656.3 NM_019413.2_2 - 0.00067 20.1 2.2 0.51 10.8 0.0 3.6 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Big_4 PF07532.9 NM_019413.2_2 - 1.4 8.5 4.6 1.2 8.8 0.1 2.8 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 4) BTB PF00651.29 NM_178744.2_2 - 3e-19 69.1 1.5 7e-19 68.0 1.5 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 NM_178744.2_2 - 2.4e-08 34.0 59.6 0.16 12.8 0.3 10.2 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2 PF00096.24 NM_178744.2_2 - 5.4e-07 29.6 55.7 0.067 13.5 0.1 10.0 9 0 0 9 9 9 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 NM_178744.2_2 - 0.00045 20.4 43.1 0.00061 20.0 2.8 8.8 8 0 0 8 8 8 3 Zinc-finger double domain zf-C2H2_jaz PF12171.6 NM_178744.2_2 - 0.038 14.2 0.2 0.038 14.2 0.2 7.3 8 0 0 8 8 8 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 NM_178744.2_2 - 0.5 10.3 19.3 1.7 8.5 1.8 5.1 3 1 1 5 5 5 0 CpXC protein Homeobox PF00046.27 NM_199449.2_3 - 1.5e-23 82.2 13.5 2.3e-06 27.2 0.5 4.4 4 0 0 4 4 4 4 Homeobox domain Homeobox_KN PF05920.9 NM_199449.2_3 - 4.7e-14 51.9 6.8 0.0031 17.3 0.0 4.5 4 0 0 4 4 4 4 Homeobox KN domain zf-H2C2_5 PF13909.4 NM_199449.2_3 - 0.052 13.2 7.0 0.21 11.2 0.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.5 NM_199449.2_3 - 0.057 13.6 0.2 0.057 13.6 0.2 3.0 3 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) BNR_2 PF13088.4 NM_001310769.1_1 - 8.6e-31 107.1 0.0 7.2e-26 91.0 0.0 2.1 2 0 0 2 2 2 2 BNR repeat-like domain BNR_3 PF13859.4 NM_001310769.1_1 - 9.6e-06 25.0 0.0 1.3e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 NM_001310769.1_1 - 0.3 11.1 6.1 0.15 12.0 0.9 3.2 4 0 0 4 4 4 0 BNR/Asp-box repeat zf-H2C2_2 PF13465.4 NM_181322.3_1 - 2.8e-48 160.1 93.2 1.7e-08 34.4 0.7 11.7 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 NM_181322.3_1 - 5e-31 105.3 102.1 0.00015 21.9 1.1 11.8 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_181322.3_1 - 1.7e-23 81.1 96.5 0.0091 16.6 2.7 11.8 11 0 0 11 11 11 10 C2H2-type zinc finger zf-H2C2_5 PF13909.4 NM_181322.3_1 - 6.2e-16 57.7 81.0 1.8e-06 27.4 0.6 10.4 10 0 0 10 10 10 5 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 NM_181322.3_1 - 4.4e-06 26.7 61.7 0.041 14.1 0.2 11.7 10 1 2 12 12 12 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 NM_181322.3_1 - 0.013 15.7 2.5 0.013 15.7 2.5 10.3 12 0 0 12 12 12 0 Zinc-finger of C2H2 type Actin_micro PF17003.3 NM_181322.3_1 - 0.77 8.7 35.5 1.3 8.0 0.5 6.6 1 1 3 4 4 4 0 Putative actin-like family Mt_ATP-synt_D PF05873.10 NM_001177659.1_1 - 0.00061 19.5 7.1 0.00061 19.5 7.1 5.4 4 2 3 7 7 7 1 ATP synthase D chain, mitochondrial (ATP5H) NAT PF04768.11 NM_001177659.1_1 - 0.018 14.6 2.7 1.3 8.5 0.1 3.1 2 0 0 2 2 2 0 NAT, N-acetyltransferase, of N-acetylglutamate synthase Invasin_D3 PF09134.8 NM_001177659.1_1 - 0.14 11.8 0.0 0.81 9.3 0.0 2.2 2 0 0 2 2 2 0 Invasin, domain 3 Pkinase PF00069.23 NM_027260.3_1 - 3.3e-17 62.6 0.0 1.5e-16 60.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_027260.3_1 - 4.4e-12 45.7 0.0 1e-09 38.0 0.0 3.2 3 1 0 3 3 3 1 Protein tyrosine kinase DUF347 PF03988.10 NM_027260.3_1 - 0.84 9.7 2.8 57 3.9 0.0 2.4 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) Aldo_ket_red PF00248.19 NM_027582.4_2 - 1.1e-57 195.3 0.0 1.3e-57 195.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family 7tm_4 PF13853.4 NM_001011525.1_1 - 3.6e-53 181.0 21.2 4.4e-53 180.7 21.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011525.1_1 - 6.4e-17 61.5 29.5 3.5e-16 59.1 29.5 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011525.1_1 - 0.042 13.1 24.8 0.19 10.9 24.8 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Rtf2 PF04641.10 NM_011104.3_1 - 0.0025 17.1 2.5 0.0038 16.5 2.5 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Orthoreo_P10 PF07204.9 NM_011104.3_1 - 0.071 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Pkinase PF00069.23 NM_011104.3_2 - 4.6e-65 219.5 0.0 6.7e-65 218.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_011104.3_2 - 8.3e-37 126.7 0.0 1.2e-36 126.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 NM_011104.3_2 - 1.1e-31 108.3 22.4 4.9e-16 58.2 5.0 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.28 NM_011104.3_2 - 2.9e-12 46.6 0.0 4.9e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.22 NM_011104.3_2 - 2.7e-08 34.2 0.0 6.5e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 NM_011104.3_2 - 0.02 14.1 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.4 NM_011104.3_2 - 0.023 14.2 0.1 0.86 9.1 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 NM_011104.3_2 - 0.084 12.1 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3915 PF13054.4 NM_011104.3_2 - 1 9.2 4.5 2.5 8.0 4.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Zf_RING PF16744.3 NM_011104.3_2 - 9.6 6.3 14.5 6.2 6.9 4.8 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger Serinc PF03348.13 NM_019760.3_3 - 1.3e-173 577.8 15.6 1.6e-173 577.4 15.6 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) zf-H2C2_2 PF13465.4 NM_028543.3_2 - 1.2e-79 259.4 138.6 8.6e-08 32.2 1.2 14.9 15 0 0 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 NM_028543.3_2 - 9.5e-40 132.7 136.1 1.2e-05 25.3 1.3 14.0 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_028543.3_2 - 6.7e-25 85.5 128.5 0.0049 17.5 1.5 14.1 13 0 0 13 13 13 12 C2H2-type zinc finger KRAB PF01352.25 NM_028543.3_2 - 1.2e-21 75.9 0.0 2.3e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 KRAB box zf-trcl PF13451.4 NM_028543.3_2 - 1.7e-11 43.7 56.2 0.36 10.6 0.8 12.5 11 2 0 11 11 11 8 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.8 NM_028543.3_2 - 5.4e-07 29.5 64.9 0.069 13.1 0.6 8.9 3 3 5 9 9 9 6 Zinc ribbon domain DUF3268 PF11672.6 NM_028543.3_2 - 1.6e-05 25.1 65.6 0.21 11.8 1.1 7.3 5 1 3 8 8 8 6 zinc-finger-containing domain XPA_N PF01286.16 NM_028543.3_2 - 0.00012 21.9 52.4 1.5 8.8 0.4 13.0 13 0 0 13 13 13 1 XPA protein N-terminal zf-C2H2_6 PF13912.4 NM_028543.3_2 - 0.00077 19.2 92.9 1.8 8.5 1.1 14.0 14 0 0 14 14 14 8 C2H2-type zinc finger ADK_lid PF05191.12 NM_028543.3_2 - 0.32 10.9 52.7 0.13 12.2 0.8 8.2 5 3 4 9 9 9 0 Adenylate kinase, active site lid ribosomal_L24 PF17136.2 NM_028543.3_2 - 5.2 7.4 20.6 14 6.0 0.9 5.5 5 1 0 5 5 5 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 zinc_ribbon_15 PF17032.3 NM_028543.3_2 - 6.6 7.4 63.7 3.4 8.4 2.1 7.2 1 1 11 12 12 12 0 zinc-ribbon family LRR_8 PF13855.4 NM_153074.3_1 - 2.2e-06 27.2 0.2 4e-06 26.4 0.2 1.3 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.5 NM_153074.3_1 - 0.00022 21.4 0.2 0.00045 20.4 0.2 1.5 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) DUF4381 PF14316.4 NM_153074.3_1 - 0.029 14.5 0.0 0.078 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) HAP1_N PF04849.11 NM_001080808.1_1 - 2.4 7.2 73.0 0.43 9.6 50.3 4.2 1 1 2 3 3 3 0 HAP1 N-terminal conserved region CENP-F_leu_zip PF10473.7 NM_001080808.1_1 - 3.8 7.4 78.0 0.56 10.1 12.4 4.6 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_tail_1 PF01576.17 NM_001271538.1_1 - 0 1506.8 283.6 0 1506.6 283.6 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 NM_001271538.1_1 - 5.8e-283 940.1 0.0 1.5e-282 938.8 0.0 1.8 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.17 NM_001271538.1_1 - 0.0001 21.9 0.0 0.00021 20.9 0.0 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ADIP PF11559.6 NM_001271538.1_1 - 0.00058 19.8 17.6 0.00058 19.8 17.6 13.4 2 2 9 13 13 13 2 Afadin- and alpha -actinin-Binding IQ PF00612.25 NM_001271538.1_1 - 0.00088 18.7 0.3 0.0032 17.0 0.3 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_22 PF13401.4 NM_001271538.1_1 - 0.12 12.5 0.0 0.12 12.5 0.0 6.5 6 2 1 7 7 7 0 AAA domain Aurora-A_bind PF09041.8 NM_001141975.1_3 - 1.2e-36 124.4 0.7 2.6e-36 123.3 0.7 1.6 1 0 0 1 1 1 1 Aurora-A binding TPX2_importin PF12214.6 NM_001141975.1_3 - 1.4e-35 122.9 77.4 1.1e-31 110.2 11.2 7.1 3 2 3 7 7 7 4 Cell cycle regulated microtubule associated protein TPX2 PF06886.9 NM_001141975.1_3 - 2.6e-11 43.4 17.4 2.6e-11 43.4 17.4 7.8 9 0 0 9 9 9 1 Targeting protein for Xklp2 (TPX2) ASC PF00858.22 NM_021370.2_3 - 2.9e-99 332.7 6.9 3.4e-99 332.4 6.9 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Glyco_transf_22 PF03901.15 NM_018889.3_1 - 1.5e-118 396.6 33.6 1.8e-118 396.3 33.6 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PMT_2 PF13231.4 NM_018889.3_1 - 0.0011 19.1 7.3 0.0011 19.1 7.3 2.4 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase SOCS_box PF07525.14 NM_018889.3_3 - 0.0059 16.8 0.2 0.034 14.4 0.0 2.5 2 0 0 2 2 2 1 SOCS box CSF-1 PF05337.9 NM_007778.4_2 - 3.3e-91 302.6 9.0 4.6e-91 302.1 9.0 1.2 1 0 0 1 1 1 1 Macrophage colony stimulating factor-1 (CSF-1) TCL1_MTCP1 PF01840.15 NM_001289468.1_2 - 3.3e-35 120.1 3.1 5.2e-35 119.4 3.1 1.2 1 0 0 1 1 1 1 TCL1/MTCP1 family Doppel PF11466.6 NM_001289468.1_2 - 6.1 6.5 6.5 0.21 11.1 0.3 1.8 2 0 0 2 2 2 0 Prion-like protein Doppel RWD PF05773.20 NM_001145969.1_1 - 3.5e-13 49.7 0.1 6e-13 49.0 0.1 1.4 1 0 0 1 1 1 1 RWD domain DUF1115 PF06544.10 NM_001145969.1_1 - 1.1e-12 48.1 0.2 1.1e-11 44.9 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) PRA1 PF03208.17 NM_138602.4_2 - 1.7e-30 105.4 2.7 2.1e-30 105.1 2.7 1.1 1 0 0 1 1 1 1 PRA1 family protein zf-C2H2 PF00096.24 NM_008817.2_3 - 4.2e-39 130.7 78.3 9.3e-05 22.5 0.8 14.3 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_008817.2_3 - 2.6e-24 83.7 81.7 0.056 14.2 0.3 14.6 15 0 0 15 15 15 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_008817.2_3 - 2.1e-11 43.3 85.9 0.012 15.4 2.0 13.6 14 0 0 14 14 14 11 C2H2-type zinc finger zf-H2C2_2 PF13465.4 NM_008817.2_3 - 0.0031 17.8 88.7 0.39 11.1 1.5 17.5 18 1 0 18 18 18 5 Zinc-finger double domain Yippee-Mis18 PF03226.12 NM_008817.2_3 - 0.061 13.4 19.6 0.72 9.9 0.4 6.5 6 1 0 6 6 6 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Zn-ribbon_8 PF09723.8 NM_008817.2_3 - 0.55 10.3 54.8 2.6 8.1 0.2 11.9 12 0 0 12 12 12 0 Zinc ribbon domain zf-H2C2_2 PF13465.4 NM_001080964.1_2 - 9.1e-11 41.6 6.1 3e-06 27.3 0.5 5.4 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001080964.1_2 - 1.2e-10 41.1 34.1 4.4e-05 23.6 1.1 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001080964.1_2 - 0.018 15.7 36.7 0.021 15.5 1.0 4.5 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_8 PF15909.3 NM_001080964.1_2 - 0.047 13.9 7.9 0.46 10.7 2.8 2.7 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.4 NM_001080964.1_2 - 0.54 10.1 15.2 0.087 12.7 3.2 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger Hormone_2 PF00123.18 NM_011328.3_3 - 1.7e-05 24.6 0.0 2.6e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Peptide hormone TPR_2 PF07719.15 NM_152817.4_1 - 6.8e-16 56.9 16.6 0.00015 21.5 0.0 7.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.4 NM_152817.4_1 - 3.5e-12 45.9 0.8 0.03 15.0 0.0 7.4 5 2 3 8 8 7 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_152817.4_1 - 6.6e-12 44.5 4.9 0.00033 20.5 0.0 6.2 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_1 PF00515.26 NM_152817.4_1 - 1.5e-11 43.5 13.7 0.00068 19.2 0.0 6.3 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_9 PF13371.4 NM_152817.4_1 - 2.6e-10 40.2 0.0 5.1e-06 26.4 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.4 NM_152817.4_1 - 7.8e-09 35.2 0.1 0.00029 20.9 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.4 NM_152817.4_1 - 2.4e-08 34.4 0.1 0.0004 20.9 0.0 4.6 3 1 1 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_152817.4_1 - 4.8e-08 33.3 0.1 0.0024 18.2 0.0 5.4 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_11 PF13414.4 NM_152817.4_1 - 2.5e-07 30.1 0.0 0.0058 16.2 0.1 4.4 3 1 1 4 4 4 2 TPR repeat TPR_12 PF13424.4 NM_152817.4_1 - 1.1e-05 25.5 9.1 1.1 9.4 0.1 6.6 3 1 2 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.4 NM_152817.4_1 - 5.1e-05 22.9 2.2 12 6.1 0.0 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.5 NM_152817.4_1 - 0.00012 22.1 9.7 0.028 14.5 0.4 4.0 2 1 2 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 NM_152817.4_1 - 0.0011 19.3 0.2 14 6.4 0.0 5.7 6 0 0 6 6 5 0 Tetratricopeptide repeat ChAPs PF09295.8 NM_152817.4_1 - 0.0079 15.1 0.0 1.5 7.6 0.1 2.4 1 1 1 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) Fis1_TPR_C PF14853.4 NM_152817.4_1 - 0.055 13.4 0.8 6.6 6.8 0.0 4.1 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.4 NM_152817.4_1 - 0.061 12.4 0.7 0.36 9.9 0.2 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat Hexokinase_1 PF00349.19 NM_152817.4_1 - 0.15 11.9 0.4 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Hexokinase BTK PF00779.17 NM_152817.4_3 - 0.0042 16.7 0.4 0.0042 16.7 0.4 2.2 2 0 0 2 2 2 1 BTK motif CUE PF02845.14 NM_001172099.1_2 - 9.4e-14 50.7 0.2 1.6e-13 49.9 0.2 1.4 1 0 0 1 1 1 1 CUE domain JIP_LZII PF16471.3 NM_001199205.1_2 - 7.3e-29 99.6 11.9 7.3e-29 99.6 11.9 2.8 3 0 0 3 3 3 1 JNK-interacting protein leucine zipper II DUF972 PF06156.11 NM_001199205.1_2 - 0.45 11.0 6.0 1.8 9.1 4.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF972) RasGAP_C PF03836.13 NM_001199205.1_2 - 0.5 10.4 9.0 0.077 13.0 4.2 2.0 2 0 0 2 2 2 0 RasGAP C-terminus RILP PF11461.6 NM_001199205.1_2 - 0.51 10.5 6.6 0.071 13.2 0.4 2.5 2 0 0 2 2 2 0 Rab interacting lysosomal protein SOGA PF11365.6 NM_001199205.1_2 - 4.5 8.4 15.3 0.17 12.9 8.2 2.4 2 0 0 2 2 2 0 Protein SOGA LAP2alpha PF11560.6 NM_011605.3_1 - 1.1e-150 499.4 1.9 1.5e-150 498.9 1.9 1.2 1 0 0 1 1 1 1 Lamina-associated polypeptide 2 alpha Thymopoietin PF08198.9 NM_011605.3_1 - 7.9e-29 98.9 0.5 1.5e-28 98.0 0.5 1.5 1 0 0 1 1 1 1 Thymopoietin protein LEM PF03020.13 NM_011605.3_1 - 2.8e-18 65.0 1.7 3.8e-18 64.6 0.7 1.8 2 0 0 2 2 2 1 LEM domain PD-C2-AF1 PF09310.8 NM_011136.2_1 - 5.2e-139 461.6 14.9 6.9e-139 461.2 14.9 1.1 1 0 0 1 1 1 1 POU domain, class 2, associating factor 1 UPAR_LY6 PF00021.19 NM_001164039.1_3 - 2.2e-14 53.8 12.9 2.2e-14 53.8 12.9 1.8 2 0 0 2 2 2 1 u-PAR/Ly-6 domain Toxin_1 PF00087.19 NM_001164039.1_3 - 4.7e-06 26.6 12.5 4.7e-06 26.6 12.5 1.9 2 0 0 2 2 2 1 Snake toxin PfkB PF00294.22 NM_001243041.1_1 - 3.4e-78 262.9 0.1 4e-78 262.6 0.1 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase UBN_AB PF14075.4 NM_177185.4_3 - 1.1e-79 267.0 2.3 1.1e-79 267.0 2.3 1.7 2 0 0 2 2 2 1 Ubinuclein conserved middle domain HUN PF08729.8 NM_177185.4_3 - 9.3e-19 67.1 0.3 2e-18 66.0 0.3 1.6 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Lipocalin PF00061.21 NM_011016.2_3 - 4.1e-21 75.6 0.0 5.4e-21 75.2 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family EamA PF00892.18 NM_175434.3_1 - 1.3e-06 28.5 11.3 1.3e-06 28.5 11.3 2.9 2 1 0 2 2 2 1 EamA-like transporter family SLC35F PF06027.10 NM_175434.3_1 - 1e-05 25.1 23.0 1.7e-05 24.4 23.0 1.3 1 0 0 1 1 1 1 Solute carrier family 35 7tm_4 PF13853.4 NM_146457.2_2 - 8.2e-54 183.1 15.8 1e-53 182.8 15.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146457.2_2 - 1.1e-21 77.2 17.6 1.9e-21 76.4 17.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146457.2_2 - 6.8e-05 22.2 12.8 6.8e-05 22.2 12.8 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Rad51 PF08423.9 NM_001277941.1_2 - 1e-13 51.0 0.5 2.9e-06 26.6 0.0 2.2 1 1 1 2 2 2 2 Rad51 ATPase PF06745.11 NM_001277941.1_2 - 0.00016 21.0 2.7 0.00025 20.4 1.0 1.9 1 1 0 2 2 2 1 KaiC DnaB_C PF03796.13 NM_001277941.1_2 - 0.00018 20.8 0.2 0.004 16.3 0.0 2.0 1 1 0 2 2 2 1 DnaB-like helicase C terminal domain HHH_5 PF14520.4 NM_001277941.1_2 - 0.00089 19.7 0.7 0.68 10.5 0.1 2.4 2 0 0 2 2 2 2 Helix-hairpin-helix domain RecA PF00154.19 NM_001277941.1_2 - 2.8 7.2 6.1 8.7 5.6 0.3 2.1 1 1 1 2 2 2 0 recA bacterial DNA recombination protein ETRAMP PF09716.8 NM_001277941.1_3 - 0.19 11.7 0.0 0.19 11.7 0.0 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) 7tm_4 PF13853.4 NM_146975.1_1 - 5.2e-51 173.9 18.1 6.3e-51 173.6 18.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_146975.1_1 - 9.9e-26 90.4 18.9 2.3e-25 89.2 18.9 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_146975.1_1 - 4.4e-05 22.9 20.1 0.00015 21.1 20.1 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 NM_146975.1_1 - 0.04 13.1 21.5 0.64 9.1 21.5 2.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx SLC3A2_N PF16028.3 NM_146975.1_1 - 0.11 12.0 0.4 20 4.7 0.0 2.8 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus Troponin PF00992.18 NM_001163667.1_2 - 2.6e-33 115.1 34.7 2.6e-33 115.1 34.7 3.2 2 1 1 3 3 3 2 Troponin zf-C4 PF00105.16 NM_015743.3_1 - 8.9e-31 106.0 18.3 2.4e-30 104.7 18.3 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_015743.3_1 - 6e-22 78.1 0.5 9.9e-22 77.4 0.5 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor SelP_N PF04592.12 NM_015743.3_1 - 0.66 9.2 10.1 1.1 8.4 10.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PARP PF00644.18 NM_029922.3_3 - 9.6e-13 48.1 0.2 1.8e-12 47.2 0.2 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain 7tm_1 PF00001.19 NM_175493.4_1 - 1.9e-39 135.4 10.5 3.2e-39 134.6 10.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 NM_175493.4_1 - 0.0017 17.6 2.8 0.0017 17.6 2.8 1.8 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.7 NM_175493.4_1 - 0.0019 17.5 2.4 0.023 13.9 2.4 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Ig_3 PF13927.4 NM_028236.1_2 - 7.5e-13 48.8 1.9 7.7e-08 32.7 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 NM_028236.1_2 - 7e-10 38.7 0.0 0.00036 20.4 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 NM_028236.1_2 - 1.7e-09 37.7 1.4 7.1e-09 35.8 0.1 2.6 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.15 NM_028236.1_2 - 9.8e-09 35.2 0.4 4.1e-05 23.6 0.1 3.3 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_5 PF16681.3 NM_028236.1_2 - 0.00029 21.1 0.0 0.067 13.5 0.0 3.3 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain ig PF00047.23 NM_028236.1_2 - 0.00047 20.1 6.5 0.0057 16.7 0.1 3.5 4 1 0 4 4 4 1 Immunoglobulin domain Izumo-Ig PF16706.3 NM_028236.1_2 - 0.032 14.1 0.0 3.5 7.6 0.0 3.1 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 NM_028236.1_2 - 0.18 11.7 4.1 2.7 8.0 0.0 3.4 3 1 1 4 4 4 0 CD80-like C2-set immunoglobulin domain FEZ PF07763.11 NM_183171.4_1 - 6.1e-83 278.1 21.1 8.2e-83 277.7 21.1 1.2 1 0 0 1 1 1 1 FEZ-like protein DUF5102 PF17104.3 NM_183171.4_1 - 0.0066 16.4 10.8 0.014 15.3 3.5 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF5102) EURL PF06937.9 NM_183171.4_1 - 0.0094 15.3 3.5 0.014 14.7 2.6 1.8 1 1 0 1 1 1 1 EURL protein 4_1_CTD PF05902.11 NM_001006664.3_2 - 6.1e-32 109.9 5.1 1.6e-31 108.5 5.1 1.7 1 1 0 1 1 1 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.8 NM_001006664.3_2 - 1.9e-24 85.7 0.0 3.3e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain SAB PF04382.11 NM_001006664.3_2 - 4.3e-22 77.8 3.2 1.1e-21 76.5 3.2 1.7 1 0 0 1 1 1 1 SAB domain FERM_N PF09379.8 NM_001006664.3_2 - 5.2e-20 71.0 0.1 1.4e-19 69.7 0.1 1.7 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.16 NM_001006664.3_2 - 7.5e-20 71.4 0.0 1.7e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 FERM central domain FA PF08736.9 NM_001006664.3_2 - 1.1e-17 63.7 2.6 2.6e-17 62.5 2.6 1.7 1 0 0 1 1 1 1 FERM adjacent (FA) bZIP_1 PF00170.19 NM_013498.3_1 - 1.1e-18 66.9 13.0 2e-18 66.1 13.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.15 NM_013498.3_1 - 6.3e-18 63.8 2.3 1.2e-17 62.9 2.3 1.5 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.13 NM_013498.3_1 - 6.7e-07 29.2 13.6 1.3e-06 28.3 13.6 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_013498.3_1 - 1.2 9.6 12.0 0.077 13.4 6.7 1.7 2 0 0 2 2 2 0 bZIP Maf transcription factor bZIP_1 PF00170.19 NM_013498.3_2 - 2.5e-15 56.2 4.4 4.9e-15 55.2 4.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 NM_013498.3_2 - 3.6e-05 23.6 5.1 5.9e-05 22.9 5.1 1.3 1 0 0 1 1 1 1 Basic region leucine zipper FUN14 PF04930.13 NM_001313745.1_2 - 1.7e-09 37.8 13.1 5.8e-08 32.9 6.3 2.3 1 1 1 2 2 2 2 FUN14 family MgtE PF01769.14 NM_177388.3_2 - 6.8e-50 168.4 14.1 2e-29 102.4 1.3 4.6 5 0 0 5 5 5 2 Divalent cation transporter DUF4083 PF13314.4 NM_177388.3_2 - 1.3 8.9 6.2 4.8 7.1 6.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) TMEM173 PF15009.4 NM_001289591.1_3 - 2e-120 401.3 0.4 2.9e-120 400.7 0.4 1.2 1 0 0 1 1 1 1 Transmembrane protein 173 Integrin_alpha2 PF08441.10 NM_008400.3_3 - 2.5e-43 148.5 0.0 3.7e-43 147.9 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 NM_008400.3_3 - 1.4e-30 106.8 1.0 1.9e-30 106.3 1.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 NM_008400.3_3 - 1.2e-14 54.0 7.9 2.3e-07 30.7 0.1 4.0 4 0 0 4 4 4 3 FG-GAP repeat VWA_2 PF13519.4 NM_008400.3_3 - 3.9e-08 33.8 0.0 7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 NM_008400.3_3 - 5.3e-05 23.6 0.0 0.019 15.4 0.0 2.8 2 1 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 NM_008400.3_3 - 0.0001 22.3 9.2 0.038 14.1 0.3 4.5 4 0 0 4 4 4 2 FG-GAP repeat Integrin_alpha PF00357.18 NM_008400.3_3 - 0.00044 19.9 0.4 0.00044 19.9 0.4 1.9 2 0 0 2 2 2 1 Integrin alpha cytoplasmic region Ldl_recept_b PF00058.15 NM_010113.4_2 - 2.4e-46 155.8 6.2 2.2e-09 37.5 0.0 9.3 10 0 0 10 10 10 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 NM_010113.4_2 - 2.2e-29 101.3 125.2 1e-09 38.3 6.4 9.6 9 0 0 9 9 9 6 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 NM_010113.4_2 - 2.3e-20 72.3 38.4 2.2e-09 37.2 7.0 9.1 9 0 0 9 9 9 4 Calcium-binding EGF domain cEGF PF12662.5 NM_010113.4_2 - 3.4e-19 68.3 63.8 1.4e-05 24.8 1.7 9.3 9 0 0 9 9 9 7 Complement Clr-like EGF-like EGF PF00008.25 NM_010113.4_2 - 1.2e-16 60.6 107.8 1.1e-05 25.5 5.8 9.5 9 0 0 9 9 9 6 EGF-like domain EGF_3 PF12947.5 NM_010113.4_2 - 4.6e-09 36.2 106.2 3.2e-05 23.9 6.6 9.0 9 1 1 10 10 10 6 EGF domain EGF_MSP1_1 PF12946.5 NM_010113.4_2 - 0.0049 16.8 6.1 0.0049 16.8 6.1 8.1 6 1 2 8 8 8 3 MSP1 EGF domain 1 hEGF PF12661.5 NM_010113.4_2 - 0.018 15.6 1.6 0.018 15.6 1.6 9.1 8 0 0 8 8 8 0 Human growth factor-like EGF Plasmod_Pvs28 PF06247.9 NM_010113.4_2 - 0.33 11.1 58.7 0.092 12.9 5.8 7.8 8 0 0 8 8 8 0 Pvs28 EGF domain PT PF04886.10 NM_001253369.1_1 - 0.00042 19.7 8.7 0.0015 17.9 8.7 1.9 1 0 0 1 1 1 1 PT repeat PT PF04886.10 NM_001253369.1_2 - 0.00093 18.6 4.0 0.0018 17.6 4.0 1.5 1 0 0 1 1 1 1 PT repeat BK_channel_a PF03493.16 NM_001253369.1_3 - 1.1e-32 112.0 0.2 2.3e-32 111.0 0.2 1.6 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.29 NM_001253369.1_3 - 9.8e-18 64.1 20.1 2.5e-17 62.8 20.1 1.6 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 NM_001253369.1_3 - 1.1e-13 50.8 4.1 1.1e-13 50.8 4.1 2.6 2 0 0 2 2 2 1 Ion channel TrkA_N PF02254.16 NM_001253369.1_3 - 4e-05 23.7 0.0 0.00023 21.2 0.0 2.1 2 0 0 2 2 2 1 TrkA-N domain Lig_chan PF00060.24 NM_001253369.1_3 - 0.26 11.0 3.9 0.88 9.3 1.1 2.5 2 0 0 2 2 2 0 Ligand-gated ion channel Peptidase_M14 PF00246.22 NM_007753.2_2 - 1.1e-89 300.9 0.1 1.5e-89 300.5 0.1 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.14 NM_007753.2_2 - 6.1e-18 64.9 2.9 1.2e-17 63.9 2.9 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide GATase1_like PF07090.9 NM_007753.2_2 - 0.0069 15.8 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 Putative glutamine amidotransferase DUF1642 PF07852.9 NM_007753.2_2 - 0.024 15.1 2.1 0.024 15.1 2.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1642) FAM180 PF15173.4 NM_007753.2_2 - 0.041 13.7 0.4 0.094 12.5 0.3 1.6 1 1 0 1 1 1 0 FAM180 family QIL1 PF15884.3 NM_007753.2_2 - 0.11 13.0 0.2 0.4 11.1 0.1 2.1 2 0 0 2 2 2 0 Protein QIL1 ATP-gua_Ptrans PF00217.17 NM_009897.2_3 - 1.2e-95 319.6 0.0 1.5e-95 319.3 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 NM_009897.2_3 - 2.3e-31 107.9 0.0 3.6e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain L_HMGIC_fpl PF10242.7 NM_001081231.2_1 - 4.9e-68 228.8 15.4 7.5e-68 228.2 15.4 1.3 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.4 NM_001081231.2_1 - 9.2e-05 22.1 7.6 0.00023 20.8 7.6 1.6 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 NM_001081231.2_1 - 0.0098 15.6 11.2 0.018 14.8 11.2 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF3496 PF12001.6 NM_178418.4_3 - 2.3e-37 127.6 4.3 2.3e-37 127.6 4.3 5.0 2 1 3 6 6 6 1 Domain of unknown function (DUF3496) Ig_2 PF13895.4 NM_172900.3_2 - 2.9e-25 88.3 4.3 1.1e-10 41.6 0.0 5.6 5 1 0 5 5 5 4 Immunoglobulin domain Ig_3 PF13927.4 NM_172900.3_2 - 3.5e-24 85.1 6.2 5e-10 39.7 0.0 5.5 5 0 0 5 5 5 3 Immunoglobulin domain I-set PF07679.14 NM_172900.3_2 - 2.4e-23 81.9 0.0 2.7e-12 46.5 0.0 5.1 5 0 0 5 5 5 2 Immunoglobulin I-set domain V-set PF07686.15 NM_172900.3_2 - 3.4e-17 62.5 5.5 4.5e-09 36.3 0.0 6.2 5 2 2 7 7 7 3 Immunoglobulin V-set domain ig PF00047.23 NM_172900.3_2 - 1.8e-16 59.9 4.3 2.4e-09 37.1 0.1 4.9 4 1 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.10 NM_172900.3_2 - 2.2e-07 30.7 14.0 0.061 13.3 0.1 5.3 4 1 0 4 4 4 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 NM_172900.3_2 - 0.021 15.1 0.0 0.75 10.1 0.0 2.5 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain 7tm_4 PF13853.4 NM_001011819.2_1 - 1.6e-52 178.9 12.5 1.9e-52 178.6 12.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_001011819.2_1 - 1.2e-18 67.2 16.7 1.7e-18 66.7 16.7 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001011819.2_1 - 5.5e-08 32.4 17.4 1.2e-07 31.3 17.4 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx UCH PF00443.27 NM_016808.2_1 - 3.8e-72 242.7 0.0 5.4e-72 242.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 NM_016808.2_1 - 1.9e-18 67.0 0.0 2.8e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C2H2_4 PF13894.4 NM_001130169.1_3 - 1.1 10.1 8.1 5.2 8.0 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger SOG2 PF10428.7 NM_001130169.1_3 - 7.1 5.6 11.9 9.9 5.2 11.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein HLH PF00010.24 NM_010419.4_2 - 1.1e-14 54.0 1.8 1.9e-14 53.2 1.8 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.11 NM_010419.4_2 - 4.9e-08 32.9 0.1 9.5e-08 32.0 0.1 1.4 1 0 0 1 1 1 1 Hairy Orange ZU5 PF00791.18 NM_178655.3_1 - 4.9e-35 119.6 0.4 1.4e-26 92.5 0.0 2.5 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 NM_178655.3_1 - 4.2e-22 78.0 0.9 7.7e-22 77.1 0.9 1.5 1 0 0 1 1 1 1 Death domain HTH_23 PF13384.4 NM_178655.3_1 - 0.073 12.8 0.0 0.29 10.8 0.0 2.1 1 0 0 1 1 1 0 Homeodomain-like domain Thioredoxin PF00085.18 NM_025868.4_1 - 7.3e-11 41.8 0.0 1.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin MFS_1 PF07690.14 NM_001038653.1_3 - 2.2e-30 105.7 35.4 1.2e-29 103.3 35.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DDE_Tnp_4 PF13359.4 NM_178724.4_2 - 1.1e-36 125.8 0.0 1.6e-36 125.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.12 NM_178724.4_2 - 4.2e-05 23.1 0.0 0.00095 18.7 0.0 2.1 1 1 0 1 1 1 1 Plant transposon protein HlyIII PF03006.18 NM_198422.2_1 - 9.6e-49 166.0 22.7 1.3e-48 165.6 22.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related Bromodomain PF00439.23 NM_053170.3_2 - 3.6e-20 71.7 1.0 7.4e-20 70.7 1.0 1.5 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.22 NM_053170.3_2 - 2.1e-10 40.4 19.8 5.7e-09 35.8 6.7 4.6 4 0 0 4 4 4 2 B-box zinc finger PHD PF00628.27 NM_053170.3_2 - 3.6e-07 29.8 10.0 3.6e-07 29.8 10.0 5.3 5 0 0 5 5 5 1 PHD-finger zf-RING_UBOX PF13445.4 NM_053170.3_2 - 9e-07 28.7 1.4 9e-07 28.7 1.4 5.2 4 1 1 5 5 5 1 RING-type zinc-finger Spc7 PF08317.9 NM_053170.3_2 - 0.29 9.8 8.3 0.51 9.0 8.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Spectrin PF00435.19 NM_053170.3_2 - 2 8.8 6.6 0.64 10.4 2.2 2.3 2 0 0 2 2 2 0 Spectrin repeat Reprolysin PF01421.17 NM_009619.5_1 - 4.1e-62 209.5 0.1 9.8e-62 208.3 0.1 1.7 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 NM_009619.5_1 - 1.7e-20 73.5 0.0 3.3e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.10 NM_009619.5_1 - 5.9e-18 65.2 8.8 5.9e-18 65.2 8.8 3.7 3 2 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 NM_009619.5_1 - 2.7e-16 60.0 28.6 2.7e-16 60.0 28.6 4.0 4 0 0 4 4 4 1 Disintegrin Reprolysin_5 PF13688.4 NM_009619.5_1 - 3.1e-07 30.6 0.1 1.6e-06 28.3 0.1 2.2 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 NM_009619.5_1 - 1e-06 29.1 0.0 2.5e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.11 NM_009619.5_1 - 7.3e-05 22.9 11.2 7.3e-05 22.9 11.2 5.6 7 0 0 7 7 7 1 EGF-like domain DUF4752 PF15944.3 NM_009619.5_1 - 0.092 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) XK-related PF09815.7 NM_176951.5_2 - 6e-83 278.5 25.9 7.7e-83 278.1 25.9 1.1 1 0 0 1 1 1 1 XK-related protein DUF2101 PF09874.7 NM_176951.5_2 - 1.1 8.8 2.8 1.7 8.1 2.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) Abhydrolase_1 PF00561.18 NM_008590.2_3 - 1.1e-15 57.8 0.1 9.8e-14 51.5 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 NM_008590.2_3 - 6.4e-09 36.6 0.0 6.4e-09 36.6 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF1057 PF06342.10 NM_008590.2_3 - 6.6e-05 22.0 0.0 9.4e-05 21.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Hydrolase_4 PF12146.6 NM_008590.2_3 - 0.00098 18.3 0.0 0.0036 16.5 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 REV PF00424.16 NM_008590.2_3 - 0.014 15.2 0.0 0.32 10.9 0.0 2.3 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Cupin_4 PF08007.10 NM_025910.3_2 - 3e-97 325.8 0.0 3.7e-97 325.5 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.4 NM_025910.3_2 - 3.2e-05 23.7 0.0 0.038 13.6 0.0 2.3 1 1 1 2 2 2 2 Cupin-like domain Cupin_2 PF07883.9 NM_025910.3_2 - 0.0017 17.9 0.0 0.038 13.6 0.0 2.3 1 1 0 1 1 1 1 Cupin domain AraC_binding PF02311.17 NM_025910.3_2 - 0.071 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 AraC-like ligand binding domain Furin-like_2 PF15913.3 NM_138683.2_3 - 7.7e-47 157.8 20.8 1.7e-46 156.6 20.8 1.6 1 0 0 1 1 1 1 Furin-like repeat, cysteine-rich TSP_1 PF00090.17 NM_138683.2_3 - 4.4e-05 23.5 8.0 4.4e-05 23.5 8.0 3.1 2 1 1 3 3 3 1 Thrombospondin type 1 domain DUF4700 PF15771.3 NM_138683.2_3 - 4.9 5.6 4.7 7 5.1 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4700) ACBP PF00887.17 NM_001102437.1_1 - 3e-26 91.3 0.1 5.5e-26 90.5 0.1 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein SBF PF01758.14 NM_173403.2_2 - 7.5e-35 120.2 16.9 1.5e-34 119.2 16.9 1.4 1 0 0 1 1 1 1 Sodium Bile acid symporter family OST3_OST6 PF04756.11 NM_173403.2_2 - 0.39 9.9 2.1 0.76 8.9 2.1 1.4 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family 7tm_4 PF13853.4 NM_147039.2_1 - 2.9e-51 174.7 21.0 3.6e-51 174.4 21.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147039.2_1 - 6.3e-15 55.0 28.0 3.8e-14 52.5 28.0 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sugar_tr PF00083.22 NM_001085529.1_1 - 2.4e-118 395.7 19.4 2.9e-118 395.5 19.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 NM_001085529.1_1 - 1.1e-19 70.5 32.6 1.5e-14 53.5 12.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RDD PF06271.10 NM_001085529.1_1 - 0.018 15.1 2.4 0.018 15.1 2.4 3.3 3 2 0 3 3 3 0 RDD family Phage_holin_2_1 PF04971.10 NM_001085529.1_1 - 2.5 8.0 7.6 11 5.9 0.1 3.2 3 0 0 3 3 3 0 Bacteriophage P21 holin S DUF719 PF05334.11 NM_001168668.1_3 - 3.7e-67 226.1 6.9 6.7e-67 225.3 1.7 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF719) Ets PF00178.20 NM_012051.4_3 - 6.8e-33 112.9 2.6 1.2e-32 112.1 2.6 1.4 1 0 0 1 1 1 1 Ets-domain Sel1 PF08238.10 NM_026278.3_2 - 1.5e-24 85.7 17.2 1.4e-06 28.6 1.2 5.7 5 0 0 5 5 5 4 Sel1 repeat TPR_2 PF07719.15 NM_026278.3_2 - 8.9e-05 22.2 14.7 0.001 18.9 1.7 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.4 NM_026278.3_2 - 0.00013 21.8 11.5 0.019 15.0 0.5 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.26 NM_026278.3_2 - 0.012 15.3 13.1 0.13 12.0 0.7 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.4 NM_026278.3_2 - 0.022 15.2 0.7 0.65 10.4 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.4 NM_026278.3_2 - 0.31 11.6 11.6 20 6.0 0.4 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.4 NM_026278.3_2 - 0.36 10.4 9.1 1.2 8.7 1.6 3.5 3 0 0 3 3 3 0 TPR repeat TPR_16 PF13432.4 NM_026278.3_2 - 0.59 10.8 11.8 0.039 14.5 1.5 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Gp_dh_C PF02800.18 NM_008084.3_1 - 2.5e-70 235.0 0.0 3.5e-70 234.5 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 NM_008084.3_1 - 5.2e-39 132.5 0.2 9.3e-39 131.7 0.2 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.18 NM_008084.3_1 - 0.037 14.0 0.1 0.09 12.8 0.1 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus PS_Dcarbxylase PF02666.13 NM_177298.3_2 - 8e-68 227.8 0.0 1.1e-67 227.4 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Cystatin PF00031.19 NM_001102411.1_1 - 1.8e-68 226.7 0.3 2.8e-26 91.5 0.0 3.4 3 0 0 3 3 3 3 Cystatin domain Cathelicidins PF00666.15 NM_001102411.1_1 - 7.5e-14 51.7 3.9 8e-05 22.8 0.1 3.4 3 0 0 3 3 3 3 Cathelicidin SQAPI PF16845.3 NM_001102411.1_1 - 3.2e-05 24.1 0.1 1.3 9.3 0.0 3.2 3 0 0 3 3 3 2 Aspartic acid proteinase inhibitor Spp-24 PF07448.9 NM_001102411.1_1 - 6e-05 23.0 2.9 0.82 9.8 0.3 3.7 3 0 0 3 3 3 2 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Keratin_2_head PF16208.3 NM_001102411.1_1 - 0.18 11.9 4.3 0.32 11.0 4.3 1.3 1 0 0 1 1 1 0 Keratin type II head V1R PF03402.12 NM_053236.2_1 - 2.6e-54 184.5 19.5 3.1e-54 184.2 19.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 NM_053236.2_1 - 0.00027 20.2 21.3 0.00035 19.8 21.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TctB PF07331.9 NM_053236.2_1 - 3.1 7.9 13.5 0.067 13.3 2.6 2.6 1 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family GATA PF00320.25 NM_008091.3_1 - 2.1e-28 97.5 19.6 4.3e-14 51.7 5.3 2.7 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 NM_008091.3_1 - 0.00013 21.3 8.3 0.056 12.8 0.7 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.8 NM_008091.3_1 - 0.1 12.6 2.1 6.8 6.8 0.1 2.7 2 0 0 2 2 2 0 Zinc ribbon domain Auto_anti-p27 PF06677.10 NM_008091.3_1 - 0.5 10.4 5.2 3.2 7.8 0.4 2.6 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.5 NM_008091.3_1 - 1.3 9.0 9.6 8.7 6.3 1.3 3.2 1 1 0 2 2 2 0 Double zinc ribbon Pkinase PF00069.23 NM_001301304.1_3 - 9.2e-50 169.3 0.0 1.4e-49 168.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_001301304.1_3 - 1.3e-23 83.5 0.0 2e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 NM_001301304.1_3 - 0.00012 21.3 0.0 0.00022 20.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 NM_001301304.1_3 - 0.056 13.2 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family BCL9 PF11502.6 NM_030256.2_2 - 5.3e-15 54.8 1.3 5.3e-15 54.8 1.3 2.6 2 0 0 2 2 2 1 B-cell lymphoma 9 protein Ten1_2 PF15490.4 NM_027107.1_2 - 5.6e-40 135.6 0.0 7.2e-40 135.3 0.0 1.1 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit DUF4677 PF15726.3 NM_177716.3_1 - 2.2e-107 357.4 5.3 3.2e-107 356.9 5.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4677) Reo_sigmaC PF04582.10 NM_177716.3_1 - 0.052 12.8 0.0 0.075 12.3 0.0 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Pkinase_Tyr PF07714.15 NM_001079909.2_1 - 5.1e-104 347.0 0.0 8.6e-104 346.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_001079909.2_1 - 1.2e-45 155.8 0.0 1.9e-45 155.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 NM_001079909.2_1 - 1e-28 99.1 0.0 1.2e-13 50.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001079909.2_1 - 1.3e-24 86.5 0.1 1.6e-11 44.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 NM_001079909.2_1 - 4e-19 68.4 0.1 1.1e-08 35.0 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 NM_001079909.2_1 - 1.7e-18 66.6 0.2 9e-10 38.6 0.1 3.0 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 NM_001079909.2_1 - 1.3e-09 38.0 0.1 0.00038 20.4 0.0 3.4 3 1 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 NM_001079909.2_1 - 0.0052 16.7 0.0 0.59 10.1 0.0 2.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain DUF4611 PF15387.4 NM_001079909.2_1 - 0.14 12.2 1.4 0.29 11.3 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Cyclin_N PF00134.21 NM_197989.1_2 - 5e-13 48.8 0.0 3.9e-12 45.9 0.0 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Lipocalin PF00061.21 NM_178036.4_1 - 1.2e-05 25.4 0.0 1.7e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Cnd1 PF12717.5 NM_178113.3_2 - 4.2e-32 111.2 21.2 4.2e-26 91.8 0.1 6.7 6 1 1 7 7 7 4 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 NM_178113.3_2 - 5.6e-10 38.4 13.8 0.22 11.7 0.0 8.5 9 0 0 9 9 9 4 HEAT repeat Adaptin_N PF01602.18 NM_178113.3_2 - 1e-07 30.8 15.6 0.00078 18.0 2.4 4.5 4 1 0 4 4 4 2 Adaptin N terminal region HEAT_2 PF13646.4 NM_178113.3_2 - 1.2e-05 25.5 0.2 0.39 11.0 0.0 3.9 2 1 1 3 3 3 3 HEAT repeats RTP1_C1 PF10363.7 NM_178113.3_2 - 7.2e-05 22.8 6.1 2.9 7.9 0.1 6.5 5 1 1 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.5 NM_178113.3_2 - 8.5e-05 21.8 0.2 8.5e-05 21.8 0.2 4.0 4 1 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain DUF3013 PF11217.6 NM_178113.3_2 - 0.0087 15.8 0.2 0.017 14.9 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3013) Cohesin_HEAT PF12765.5 NM_178113.3_2 - 0.021 14.9 0.3 2.4 8.3 0.0 3.8 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion DUF1043 PF06295.10 NM_178113.3_2 - 0.033 14.0 0.0 0.098 12.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Rad60-SLD PF11976.6 NM_001301673.1_3 - 2.9e-24 84.5 0.1 4.2e-24 84.0 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 NM_001301673.1_3 - 2.5e-10 39.8 0.1 3.6e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family WD40 PF00400.30 NM_134015.3_1 - 1.3e-36 123.8 19.2 1.9e-06 28.4 0.2 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat Beta-TrCP_D PF12125.6 NM_134015.3_1 - 6.6e-25 86.6 2.0 6.6e-25 86.6 2.0 1.8 2 0 0 2 2 2 1 D domain of beta-TrCP ANAPC4_WD40 PF12894.5 NM_134015.3_1 - 2.3e-09 37.3 2.3 0.024 14.8 0.1 4.2 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.5 NM_134015.3_1 - 2.8e-09 36.6 0.1 7.4e-09 35.2 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 NM_134015.3_1 - 5.6e-06 26.0 0.0 1.5e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.3 NM_134015.3_1 - 2.2e-05 23.8 0.2 0.036 13.3 0.5 2.4 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.6 NM_134015.3_1 - 0.0063 15.0 10.3 0.28 9.6 0.2 3.8 3 2 1 4 4 4 2 Nucleoporin Nup120/160 CAP_N PF01213.17 NM_134015.3_1 - 2.2 7.5 5.8 3.5 6.9 5.8 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Sarcoglycan_1 PF04790.11 NM_011891.4_2 - 8.7e-78 261.1 0.0 1.1e-77 260.8 0.0 1.1 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.7 NM_011891.4_2 - 0.012 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2345) SCAN PF02023.15 NM_001251834.1_2 - 3.6e-37 125.9 4.2 5.1e-37 125.5 4.2 1.2 1 0 0 1 1 1 1 SCAN domain AIF_C PF14721.4 NM_001290364.1_1 - 1.5e-57 193.4 0.0 2.3e-57 192.8 0.0 1.3 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox_2 PF07992.12 NM_001290364.1_1 - 2.5e-40 138.4 0.0 3.9e-40 137.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 NM_001290364.1_1 - 5.7e-13 49.1 0.2 6.6e-11 42.5 0.1 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AIF-MLS PF14962.4 NM_001290364.1_1 - 2.6e-10 40.5 0.3 2.6e-10 40.5 0.3 1.6 2 0 0 2 2 2 1 Mitochondria Localisation Sequence Pyr_redox_3 PF13738.4 NM_001290364.1_1 - 5.1e-06 25.8 0.0 0.00013 21.2 0.0 2.6 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 NM_001290364.1_1 - 0.00031 19.4 0.3 0.37 9.3 0.0 3.1 3 0 0 3 3 3 2 HI0933-like protein NAD_binding_9 PF13454.4 NM_001290364.1_1 - 0.001 18.9 0.4 2.3 8.1 0.0 4.0 3 1 1 4 4 4 1 FAD-NAD(P)-binding Amino_oxidase PF01593.22 NM_001290364.1_1 - 0.0059 15.8 0.3 0.3 10.2 0.0 2.1 1 1 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 NM_001290364.1_1 - 0.11 12.7 2.3 8.8 6.5 0.0 3.0 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.4 NM_001290364.1_1 - 0.14 11.2 0.1 0.4 9.6 0.0 1.7 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) C2 PF00168.28 NM_198614.3_2 - 1.2e-06 28.6 0.0 2.1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 C2 domain SNAP-25 PF00835.17 NM_011428.3_1 - 1.6e-20 73.0 0.2 3e-20 72.1 0.2 1.5 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.3 NM_011428.3_1 - 2e-05 24.4 4.9 2e-05 24.4 4.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF5089) DUF3450 PF11932.6 NM_011428.3_1 - 0.55 9.4 7.8 0.22 10.7 3.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) IncA PF04156.12 NM_011428.3_1 - 0.59 9.8 3.3 1 9.0 1.6 1.9 2 0 0 2 2 2 0 IncA protein V-SNARE_C PF12352.6 NM_011428.3_1 - 0.68 10.1 5.5 0.31 11.2 0.7 2.7 2 1 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Exonuc_VII_L PF02601.13 NM_011428.3_1 - 1.4 8.3 6.5 6.3 6.1 6.7 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.9 NM_011428.3_1 - 1.9 7.1 8.4 0.28 9.9 1.8 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.4 NM_011428.3_1 - 3.6 8.0 9.7 4.8 7.6 4.2 2.4 2 0 0 2 2 2 0 Snapin/Pallidin Alanine_zipper PF11839.6 NM_011428.3_1 - 4.7 7.4 7.0 7.4 6.8 0.1 3.1 2 1 1 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein SNARE PF05739.17 NM_011428.3_1 - 8.6 6.3 5.7 5.7 6.9 0.5 2.5 2 0 0 2 2 2 0 SNARE domain PET PF06297.12 NM_001134461.1_2 - 2.6e-37 126.9 0.7 5.5e-37 125.8 0.7 1.6 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 NM_001134461.1_2 - 2.6e-22 78.7 53.7 1.3e-09 38.0 13.8 4.8 4 0 0 4 4 4 3 LIM domain Cadherin PF00028.15 NM_053128.2_2 - 2e-77 255.6 0.0 1.4e-16 60.5 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 NM_053128.2_2 - 2.9e-34 116.6 1.6 1.5e-32 111.1 0.1 3.3 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 NM_053128.2_2 - 4.1e-25 88.3 0.0 1.1e-24 86.9 0.0 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 NM_053128.2_2 - 1.4e-09 37.8 3.7 0.0017 18.2 0.1 4.6 4 0 0 4 4 4 3 Cadherin-like SusE PF14292.4 NM_053128.2_2 - 0.027 14.7 1.3 1.2 9.5 0.2 2.8 1 1 2 3 3 3 0 SusE outer membrane protein GEMIN8 PF15348.4 NM_001310724.1_2 - 6.1e-84 281.9 5.7 8.1e-84 281.5 5.7 1.1 1 0 0 1 1 1 1 Gemini of Cajal bodies-associated protein 8 PX PF00787.22 NM_022656.2_3 - 4e-18 65.3 0.2 9.6e-18 64.1 0.2 1.6 1 0 0 1 1 1 1 PX domain LRR_8 PF13855.4 NM_022656.2_3 - 5.6e-12 45.1 15.2 7.3e-05 22.3 0.0 4.1 3 1 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 NM_022656.2_3 - 1.1e-11 44.6 23.3 1.9e-06 27.9 1.1 5.3 3 1 2 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_022656.2_3 - 9.5e-09 34.9 1.3 3.3e-05 23.3 0.2 2.8 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.4 NM_022656.2_3 - 0.013 15.3 10.7 8.5 6.6 0.1 5.3 5 0 0 5 5 5 0 Leucine Rich repeat F_actin_bind PF08919.8 NM_022656.2_3 - 0.048 13.6 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 F-actin binding LRR_1 PF00560.31 NM_022656.2_3 - 0.13 12.6 18.4 20 6.0 0.0 7.2 6 1 0 6 6 6 0 Leucine Rich Repeat ERG4_ERG24 PF01222.15 NM_007856.2_1 - 6.6e-91 305.1 19.0 8.9e-91 304.6 19.0 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Ribosomal_L14 PF00238.17 NM_022891.3_3 - 9.1e-34 116.0 0.2 9.1e-34 116.0 0.2 1.5 2 0 0 2 2 2 1 Ribosomal protein L14p/L23e Myosin_tail_1 PF01576.17 NM_022410.3_2 - 0 1668.9 311.1 0 1668.6 311.1 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 NM_022410.3_2 - 0 1023.0 0.6 0 1023.0 0.6 3.6 4 1 0 4 4 4 1 Myosin head (motor domain) Myosin_N PF02736.17 NM_022410.3_2 - 3.4e-10 39.4 1.7 8.2e-10 38.2 1.7 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 NM_022410.3_2 - 0.00046 19.6 0.1 0.0014 18.1 0.1 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif CC2-LZ PF16516.3 NM_022410.3_2 - 0.00048 20.3 21.4 0.00048 20.3 21.4 16.9 3 2 10 14 14 14 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Reo_sigmaC PF04582.10 NM_022410.3_2 - 0.0011 18.4 1.8 0.0011 18.4 1.8 8.7 2 2 3 8 8 8 5 Reovirus sigma C capsid protein ADIP PF11559.6 NM_022410.3_2 - 0.0022 17.9 20.2 0.0022 17.9 20.2 14.8 1 1 13 15 15 15 2 Afadin- and alpha -actinin-Binding AAA_22 PF13401.4 NM_022410.3_2 - 0.12 12.5 0.0 0.12 12.5 0.0 5.8 5 1 1 6 6 6 0 AAA domain DnaJ_C PF01556.16 NM_025926.4_1 - 4.5e-42 143.5 0.0 5.9e-42 143.1 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 NM_025926.4_1 - 4.4e-27 93.9 4.0 7.4e-27 93.1 4.0 1.4 1 0 0 1 1 1 1 DnaJ domain RWD PF05773.20 NM_027100.2_3 - 4.1e-13 49.5 0.1 6.9e-13 48.8 0.1 1.4 1 0 0 1 1 1 1 RWD domain DUF1115 PF06544.10 NM_027100.2_3 - 1.4e-12 47.8 0.2 1.2e-11 44.7 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) Pkinase_Tyr PF07714.15 NM_009759.4_3 - 7.4e-94 313.7 0.1 1.1e-93 313.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_009759.4_3 - 1e-46 159.3 0.0 1.6e-46 158.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 NM_009759.4_3 - 6.2e-21 74.1 0.3 1.3e-20 73.1 0.3 1.6 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 NM_009759.4_3 - 9.6e-18 64.5 1.3 2.3e-17 63.3 1.3 1.7 1 0 0 1 1 1 1 PH domain BTK PF00779.17 NM_009759.4_3 - 1.2e-12 47.2 3.7 2.7e-12 46.1 3.7 1.6 1 0 0 1 1 1 1 BTK motif PH_8 PF15409.4 NM_009759.4_3 - 0.024 14.8 4.8 1.1 9.5 3.5 2.9 2 2 0 2 2 2 0 Pleckstrin homology domain Kinase-like PF14531.4 NM_009759.4_3 - 0.027 13.6 0.0 0.051 12.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like PH_11 PF15413.4 NM_009759.4_3 - 0.19 12.0 3.1 1.2 9.5 3.1 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain ISK_Channel PF02060.13 NM_134110.3_1 - 3.7e-15 55.6 0.3 6.5e-15 54.8 0.3 1.4 1 0 0 1 1 1 1 Slow voltage-gated potassium channel DUF4604 PF15377.4 NM_025609.2_1 - 1.4 9.2 16.9 2 8.7 16.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) SR-25 PF10500.7 NM_025609.2_2 - 0.11 12.0 20.8 0.18 11.3 20.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PP2C PF00481.19 NM_025609.2_3 - 1.2e-39 136.4 0.0 1.7e-39 135.9 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C bZIP_2 PF07716.13 NM_001290183.1_3 - 7.2e-05 22.7 10.7 0.00017 21.5 10.7 1.6 1 0 0 1 1 1 1 Basic region leucine zipper GAS PF13851.4 NM_001290183.1_3 - 0.0014 17.9 7.6 0.0028 16.9 7.6 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding bZIP_1 PF00170.19 NM_001290183.1_3 - 0.0063 16.5 12.9 0.014 15.3 12.9 1.6 1 0 0 1 1 1 1 bZIP transcription factor DivIC PF04977.13 NM_001290183.1_3 - 0.037 13.6 6.6 0.084 12.5 6.6 1.5 1 0 0 1 1 1 0 Septum formation initiator GIT_CC PF16559.3 NM_001290183.1_3 - 0.071 13.0 1.5 0.15 12.0 1.5 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CLZ PF16526.3 NM_001290183.1_3 - 0.089 13.0 6.4 0.21 11.8 6.4 1.6 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels RR_TM4-6 PF06459.10 NM_001290183.1_3 - 0.65 9.6 8.2 0.89 9.2 8.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MAJIN PF15077.4 NM_001290183.1_3 - 0.78 9.5 7.3 1.1 9.0 7.3 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF1003 PF06210.9 NM_001290183.1_3 - 1.6 8.8 4.7 3.3 7.8 4.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) IncA PF04156.12 NM_001290183.1_3 - 2 8.1 9.9 1 9.0 7.4 1.8 2 0 0 2 2 2 0 IncA protein HemX PF04375.12 NM_001290183.1_3 - 2.6 7.1 7.9 3.8 6.6 7.9 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase CDC45 PF02724.12 NM_001290183.1_3 - 2.9 6.0 8.4 3.3 5.8 8.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4407 PF14362.4 NM_001290183.1_3 - 9.4 5.4 11.6 4.5 6.4 7.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) RasGEF PF00617.17 NM_145149.4_3 - 5.2e-39 134.0 0.0 1e-38 133.1 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 NM_145149.4_3 - 4.8e-11 42.2 15.3 1.3e-10 40.9 15.3 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_7 PF13499.4 NM_145149.4_3 - 0.00087 19.6 0.0 0.18 12.2 0.0 2.7 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 NM_145149.4_3 - 0.098 12.5 0.0 0.58 10.1 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.30 NM_145149.4_3 - 0.14 11.7 0.0 0.53 9.8 0.0 2.0 2 0 0 2 2 2 0 EF hand SAMP PF05924.9 NM_145149.4_3 - 0.94 8.7 2.8 2.2 7.5 2.8 1.7 1 0 0 1 1 1 0 SAMP Motif Filament PF00038.19 NM_023485.3_2 - 2.3e-14 53.6 46.9 4e-14 52.8 46.9 1.3 1 0 0 1 1 1 1 Intermediate filament protein DUF2935 PF11155.6 NM_023485.3_2 - 0.012 15.8 10.3 7 6.9 1.3 4.2 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) Hanta_nucleocap PF00846.16 NM_023485.3_2 - 0.083 11.2 2.7 0.13 10.5 2.7 1.2 1 0 0 1 1 1 0 Hantavirus nucleocapsid protein DUF3584 PF12128.6 NM_023485.3_2 - 4.2 4.6 44.7 5.6 4.2 44.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) NAD_binding_1 PF00175.19 NM_023485.3_2 - 8 7.0 6.4 1.6 9.3 1.7 2.2 2 1 1 3 3 3 0 Oxidoreductase NAD-binding domain AAA_13 PF13166.4 NM_023485.3_2 - 9 4.7 26.2 0.14 10.7 15.7 2.1 1 1 1 2 2 2 0 AAA domain ERM PF00769.17 NM_023485.3_2 - 9.4 5.8 55.9 1.6 8.4 31.6 2.9 1 1 1 2 2 2 0 Ezrin/radixin/moesin family BicD PF09730.7 NM_009753.4_2 - 0 1155.0 65.8 0 1155.0 65.8 1.9 2 0 0 2 2 2 1 Microtubule-associated protein Bicaudal-D PK PF00224.19 NM_001099779.1_3 - 1e-161 537.5 0.4 1.2e-161 537.2 0.4 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 NM_001099779.1_3 - 1.6e-30 105.6 0.0 3.6e-30 104.4 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain IMPDH PF00478.23 NM_001099779.1_3 - 0.0085 15.0 0.2 0.03 13.2 0.0 1.9 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Reo_sigmaC PF04582.10 NM_001201378.1_1 - 0.0052 16.1 1.8 0.0052 16.1 1.8 3.9 1 1 2 4 4 4 1 Reovirus sigma C capsid protein IncA PF04156.12 NM_001201378.1_1 - 0.0076 15.9 3.9 0.0076 15.9 3.9 8.9 3 2 4 7 7 7 3 IncA protein Ras PF00071.20 NM_011227.1_1 - 1.7e-31 108.9 0.0 5.4e-31 107.2 0.0 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.11 NM_011227.1_1 - 3.6e-23 81.9 0.0 6.1e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_011227.1_1 - 1.8e-12 47.0 0.0 2.7e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 NM_011227.1_1 - 0.00046 20.1 0.0 0.00096 19.1 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.8 NM_011227.1_1 - 0.073 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.9 NM_011227.1_1 - 0.13 11.3 0.0 0.28 10.2 0.0 1.5 2 0 0 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.7 NM_011227.1_1 - 0.15 11.7 0.0 0.45 10.1 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Med12-LCEWAV PF12145.6 NM_021521.2_3 - 2.9e-182 606.6 0.0 2.9e-182 606.6 0.0 2.3 2 0 0 2 2 2 1 Eukaryotic Mediator 12 subunit domain Med12-PQL PF12144.6 NM_021521.2_3 - 1e-83 280.2 34.9 1e-83 280.2 34.9 3.7 3 1 1 4 4 4 1 Eukaryotic Mediator 12 catenin-binding domain Med12 PF09497.8 NM_021521.2_3 - 3.2e-14 52.8 0.1 7.1e-14 51.7 0.1 1.6 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 PA26 PF04636.11 NM_021521.2_3 - 3.9 6.2 24.4 6.7 5.4 24.4 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) EF-hand_7 PF13499.4 NM_011870.5_3 - 9.1e-11 41.9 6.8 1.7e-10 41.1 2.1 2.7 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 NM_011870.5_3 - 1.3e-10 39.9 4.3 0.0001 21.4 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 NM_011870.5_3 - 3.1e-08 32.8 6.2 0.00012 21.6 0.4 3.7 4 1 1 5 5 5 2 EF-hand domain EF-hand_8 PF13833.4 NM_011870.5_3 - 3.5e-07 29.8 4.8 0.0048 16.5 1.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 NM_011870.5_3 - 6.9e-07 28.4 4.1 0.0071 15.7 0.5 3.0 2 1 1 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.7 NM_011870.5_3 - 0.019 15.1 0.3 0.12 12.6 0.3 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 NM_011870.5_3 - 0.099 12.5 2.8 0.54 10.1 0.2 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand BORG_CEP PF14957.4 NM_020006.2_3 - 1.2e-20 74.7 1.3 1.2e-20 74.7 1.3 1.8 2 0 0 2 2 2 1 Cdc42 effector PBD PF00786.26 NM_020006.2_3 - 2.9e-11 43.4 0.0 5.8e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain GGACT PF06094.10 NM_145466.2_3 - 4.2e-23 82.1 0.0 5.5e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.4 NM_145466.2_3 - 0.041 14.1 0.0 0.069 13.4 0.0 1.3 1 0 0 1 1 1 0 AIG2-like family Lactamase_B PF00753.25 NM_028372.1_2 - 5.3e-19 68.9 0.4 8.2e-19 68.2 0.4 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily TMEM174 PF15029.4 NM_026685.2_1 - 4.4e-117 389.7 0.2 6.7e-117 389.1 0.2 1.3 1 0 0 1 1 1 1 Transmembrane protein 174 HAUS2 PF15003.4 NM_001290808.1_2 - 1.6e-41 142.0 2.0 2.2e-41 141.5 2.0 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 HAUS2 PF15003.4 NM_001290808.1_3 - 9.1e-10 38.4 0.1 1.2e-09 38.0 0.1 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 START PF01852.17 NM_001289649.1_3 - 3.8e-26 91.7 0.0 5.6e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 START domain PMG PF05287.10 NM_027173.1_3 - 3.1e-50 170.6 54.0 4.3e-50 170.1 54.0 1.2 1 0 0 1 1 1 1 PMG protein bZIP_1 PF00170.19 NM_007497.3_3 - 1.6e-20 72.8 9.4 3e-20 71.9 9.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.15 NM_007497.3_3 - 6e-18 63.9 1.9 6e-18 63.9 1.9 2.6 3 0 0 3 3 3 1 pKID domain bZIP_2 PF07716.13 NM_007497.3_3 - 3.2e-08 33.4 8.4 5.4e-08 32.7 8.4 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 NM_007497.3_3 - 0.0012 19.2 5.3 0.0026 18.1 5.3 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor ASD2 PF08687.9 NM_007497.3_3 - 0.041 13.4 2.6 0.072 12.6 2.6 1.3 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Mtc PF03820.15 NM_001178013.1_1 - 9e-125 415.7 0.4 8.6e-106 353.4 0.1 2.2 1 1 1 2 2 2 2 Tricarboxylate carrier TRAF_BIRC3_bd PF16673.3 NM_028384.1_1 - 1.7 8.3 25.0 0.26 11.0 0.6 5.3 5 0 0 5 5 5 0 TNF receptor-associated factor BIRC3 binding domain SPO22 PF08631.8 NM_001167997.1_3 - 2.8e-62 210.5 5.7 1e-58 198.9 1.9 2.4 2 0 0 2 2 2 2 Meiosis protein SPO22/ZIP4 like TPR_2 PF07719.15 NM_001167997.1_3 - 0.0002 21.1 5.0 3 8.1 0.1 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.4 NM_001167997.1_3 - 0.00036 20.9 0.2 0.0017 18.7 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 NM_001167997.1_3 - 0.028 14.6 1.7 7.5 6.8 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 NM_001167997.1_3 - 0.078 12.7 7.2 6.2 6.7 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat SPOB_a PF14689.4 NM_001167997.1_3 - 0.095 12.3 0.6 2.6 7.7 0.0 3.3 3 0 0 3 3 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_8 PF13181.4 NM_001167997.1_3 - 0.86 9.9 3.3 7.7 6.9 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat V1R PF03402.12 NM_207544.1_1 - 5.2e-18 65.5 13.1 6.7e-18 65.1 13.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_207544.1_1 - 1.4e-11 44.0 17.2 2e-11 43.4 17.2 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) PID PF00640.21 NM_021921.3_2 - 6.1e-32 110.4 0.0 9.4e-32 109.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH3_9 PF14604.4 NM_021921.3_2 - 1e-13 50.7 0.1 2.2e-13 49.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_021921.3_2 - 8.2e-06 25.2 0.0 1.5e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_021921.3_2 - 0.093 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain Myc_N PF01056.16 NM_021921.3_2 - 0.2 11.4 8.3 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 Myc amino-terminal region FAM176 PF14851.4 NM_021921.3_2 - 0.67 9.5 10.5 1.5 8.3 0.4 2.6 2 0 0 2 2 2 0 FAM176 family RXT2_N PF08595.9 NM_021921.3_2 - 2.1 8.2 7.0 13 5.6 0.3 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal PBP1_TM PF14812.4 NM_021921.3_2 - 2.8 8.3 10.9 16 5.8 4.2 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sigma70_ner PF04546.11 NM_021921.3_2 - 3.5 7.3 10.6 6.9 6.3 3.1 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region Chromo_shadow PF01393.17 NM_001076789.1_2 - 5.7e-28 96.6 0.8 8.4e-26 89.6 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.22 NM_001076789.1_2 - 2.8e-17 62.2 0.7 3.1e-16 58.9 0.5 2.3 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.4 NM_001076789.1_2 - 0.07 13.2 0.2 0.14 12.2 0.2 1.5 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 I-set PF07679.14 NM_001293769.1_3 - 0.00016 21.6 0.0 0.00028 20.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 NM_001293769.1_3 - 0.00094 19.6 0.0 0.0021 18.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 NM_001293769.1_3 - 0.085 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain Polyketide_cyc PF03364.18 NM_001039710.1_1 - 1.1e-20 74.1 0.0 1.4e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sema PF01403.17 NM_009154.2_2 - 1.3e-131 439.2 0.0 1.7e-131 438.8 0.0 1.1 1 0 0 1 1 1 1 Sema domain TSP_1 PF00090.17 NM_009154.2_2 - 4.5e-42 141.9 99.9 5e-11 42.5 8.3 7.7 7 0 0 7 7 7 6 Thrombospondin type 1 domain Zip PF02535.20 NM_139143.3_1 - 1e-102 343.7 41.7 2.5e-101 339.1 17.1 3.1 2 1 0 2 2 2 2 ZIP Zinc transporter Period_C PF12114.6 NM_011065.4_1 - 3.7e-76 254.9 3.4 3.7e-76 254.9 3.4 3.2 3 0 0 3 3 3 1 Period protein 2/3C-terminal region PAS_3 PF08447.10 NM_011065.4_1 - 3.3e-11 43.2 0.0 7.3e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.4 NM_011065.4_1 - 4.9e-08 33.0 0.0 9.3e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS PF00989.23 NM_011065.4_1 - 5.6e-06 26.2 0.0 0.00027 20.8 0.0 2.4 2 0 0 2 2 2 1 PAS fold DUF4698 PF15769.3 NM_011065.4_1 - 2.2 7.1 8.0 1.7 7.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4698) CwfJ_C_1 PF04677.13 NM_027545.2_2 - 1.3e-37 128.3 1.4 2.7e-37 127.2 1.4 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.12 NM_027545.2_2 - 3.4e-30 104.7 0.0 3.4e-30 104.7 0.0 3.9 4 0 0 4 4 4 1 Protein similar to CwfJ C-terminus 2 RRM_1 PF00076.20 NM_019711.2_1 - 5.5e-30 102.9 0.0 6.1e-15 54.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spin-Ssty PF02513.15 NM_001160135.2_3 - 3.2e-59 196.3 10.8 3e-22 77.9 0.1 3.2 3 0 0 3 3 3 3 Spin/Ssty Family FAM24 PF15193.4 NM_183272.2_2 - 2.6e-31 108.0 7.0 3.2e-31 107.7 7.0 1.1 1 0 0 1 1 1 1 FAM24 family RUN PF02759.17 NM_028964.4_3 - 1.8e-24 86.1 0.2 4.4e-24 84.8 0.2 1.7 1 0 0 1 1 1 1 RUN domain PX PF00787.22 NM_028964.4_3 - 3.8e-19 68.6 0.2 1.3e-18 66.9 0.2 1.9 1 0 0 1 1 1 1 PX domain TSC22 PF01166.16 NM_028964.4_3 - 0.00026 21.1 9.8 0.055 13.7 0.5 2.7 1 1 1 2 2 2 2 TSC-22/dip/bun family Rootletin PF15035.4 NM_028964.4_3 - 0.00035 20.6 1.5 0.0012 18.8 1.0 2.2 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 NM_028964.4_3 - 0.11 12.2 12.7 0.34 10.6 12.7 1.8 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF972 PF06156.11 NM_028964.4_3 - 1.3 9.6 9.9 1.7 9.2 6.4 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF972) DUF1664 PF07889.10 NM_028964.4_3 - 1.5 8.7 4.4 2.1 8.2 2.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3022 PF11226.6 NM_028964.4_3 - 2.4 8.5 4.5 30 5.0 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3022) RhoGAP PF00620.25 NM_198018.2_2 - 1.6e-47 161.0 0.0 4.4e-47 159.6 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain RhoGEF PF00621.18 NM_198018.2_2 - 8e-32 110.8 2.3 1.5e-31 109.9 2.3 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 NM_198018.2_2 - 1e-09 38.7 4.6 5.9e-09 36.3 1.5 3.1 2 1 0 2 2 2 1 PH domain C2 PF00168.28 NM_198018.2_2 - 1.2e-06 28.6 0.1 2.4e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 C2 domain PH_10 PF15411.4 NM_198018.2_2 - 0.055 13.6 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Phage_antiter_Q PF06323.9 NM_198018.2_2 - 0.16 11.3 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Phage antitermination protein Q 7tm_1 PF00001.19 NM_001010828.1_1 - 6.7e-56 189.3 12.9 6.7e-56 189.3 12.9 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_001010828.1_1 - 7.8e-11 41.7 16.7 9.8e-11 41.4 16.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 NM_001010828.1_1 - 0.0013 18.4 12.3 0.002 17.8 7.3 2.4 2 1 0 2 2 2 1 Olfactory receptor Phage_holin_3_6 PF07332.9 NM_001010828.1_1 - 1 9.3 8.7 1.5 8.7 0.1 2.9 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Kelch_1 PF01344.23 NM_054102.2_1 - 4.2e-85 279.0 14.5 1.3e-15 56.5 0.1 6.9 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 NM_054102.2_1 - 9.3e-46 152.6 5.7 8.3e-10 38.5 0.0 6.8 1 1 5 6 6 6 6 Kelch motif Kelch_3 PF13415.4 NM_054102.2_1 - 5.8e-35 118.8 11.1 4.9e-08 32.9 0.1 7.0 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_2 PF07646.13 NM_054102.2_1 - 7.5e-35 117.5 3.9 5.4e-05 22.9 0.0 6.8 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.4 NM_054102.2_1 - 2.3e-31 107.3 2.7 3.2e-07 30.1 0.1 6.1 5 1 1 6 6 6 5 Galactose oxidase, central domain BTB PF00651.29 NM_054102.2_1 - 3.2e-27 94.8 0.2 5.8e-27 94.0 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 NM_054102.2_1 - 2.1e-12 46.9 0.5 4.5e-12 45.9 0.2 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_5 PF13854.4 NM_054102.2_1 - 6e-12 45.1 14.1 0.0031 17.3 0.0 6.1 7 0 0 7 7 7 4 Kelch motif PQQ_3 PF13570.4 NM_054102.2_1 - 0.031 14.6 2.9 15 6.1 0.1 4.0 4 0 0 4 4 4 0 PQQ-like domain XPA_C PF05181.10 NM_054102.2_1 - 0.12 12.2 0.4 52 3.8 0.0 3.7 3 0 0 3 3 3 0 XPA protein C-terminus Serpin PF00079.18 NM_011340.3_1 - 3.9e-83 279.7 0.0 4.5e-83 279.5 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) AMOP PF03782.15 NM_001276489.1_1 - 1.7e-26 92.9 3.7 3.2e-26 92.0 3.7 1.4 1 0 0 1 1 1 1 AMOP domain TSP_1 PF00090.17 NM_001276489.1_1 - 2e-06 27.8 9.5 2e-06 27.8 9.5 2.2 2 0 0 2 2 2 1 Thrombospondin type 1 domain SEP PF08059.11 NM_026257.3_1 - 3.8e-17 62.5 0.0 9e-17 61.3 0.0 1.7 1 0 0 1 1 1 1 SEP domain UBX PF00789.18 NM_026257.3_1 - 5.6e-06 26.3 0.0 1.9e-05 24.6 0.0 2.0 1 0 0 1 1 1 1 UBX domain FAM76 PF16046.3 NM_026257.3_1 - 0.00049 19.4 0.8 0.00075 18.8 0.8 1.2 1 0 0 1 1 1 1 FAM76 protein IncA PF04156.12 NM_026257.3_1 - 0.0041 16.8 4.7 0.0075 15.9 4.7 1.4 1 0 0 1 1 1 1 IncA protein DUF1635 PF07795.9 NM_026257.3_1 - 0.011 15.5 3.6 0.02 14.8 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) MnmE_helical PF12631.5 NM_026257.3_1 - 0.032 14.3 0.2 0.055 13.5 0.2 1.3 1 0 0 1 1 1 0 MnmE helical domain TMPIT PF07851.11 NM_026257.3_1 - 0.53 9.3 4.9 0.79 8.8 4.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein OmpH PF03938.12 NM_026257.3_1 - 0.56 10.1 12.8 1.1 9.1 12.8 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Mnd1 PF03962.13 NM_026257.3_1 - 4.2 7.1 10.1 7.9 6.2 10.1 1.4 1 0 0 1 1 1 0 Mnd1 family UPF0242 PF06785.9 NM_026257.3_1 - 5.3 5.5 5.6 8.3 4.9 5.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) Galactosyl_T PF01762.19 NM_019420.2_2 - 4.6e-64 215.7 0.0 5.8e-64 215.4 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 NM_019420.2_2 - 0.014 14.7 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Fringe-like GatB_N PF02934.13 NM_144896.4_1 - 2e-100 335.5 0.0 2.8e-100 335.1 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.16 NM_144896.4_1 - 5.2e-45 152.8 1.9 7.8e-45 152.2 1.9 1.3 1 0 0 1 1 1 1 GatB domain Proteasome PF00227.24 NM_011968.3_2 - 1.4e-53 181.1 0.2 1.8e-53 180.7 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 NM_011968.3_2 - 6e-15 54.5 0.1 1e-14 53.7 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature BAAT_C PF08840.9 NM_134188.3_3 - 7.6e-83 277.5 0.0 1e-82 277.1 0.0 1.2 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Bile_Hydr_Trans PF04775.12 NM_134188.3_3 - 4.2e-42 143.0 0.0 6.9e-42 142.3 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region DLH PF01738.16 NM_134188.3_3 - 1.2e-06 28.2 0.3 3.1e-05 23.5 0.3 2.7 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.19 NM_134188.3_3 - 0.014 14.8 0.0 0.03 13.7 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family FSH1 PF03959.11 NM_134188.3_3 - 0.032 13.8 0.0 0.032 13.8 0.0 1.6 2 0 0 2 2 2 0 Serine hydrolase (FSH1) DTW PF03942.13 NM_026854.3_1 - 2.3e-42 144.8 0.6 3e-42 144.4 0.6 1.1 1 0 0 1 1 1 1 DTW domain WD40 PF00400.30 NM_013531.4_2 - 1.8e-39 132.9 22.9 1.9e-06 28.4 0.1 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_013531.4_2 - 4.1e-11 42.9 0.0 0.0046 17.1 0.0 5.3 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 NM_013531.4_2 - 0.038 13.2 0.0 0.45 9.7 0.0 2.2 1 1 1 2 2 2 0 WD40-like domain zf-C4 PF00105.16 NM_001159548.1_3 - 6.2e-28 96.9 18.1 1.3e-27 95.9 18.1 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 NM_001159548.1_3 - 2.1e-18 66.6 4.1 3.7e-18 65.7 4.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor MFS_1 PF07690.14 NM_008246.2_2 - 5.7e-32 110.9 37.1 2.3e-31 108.9 36.4 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.5 NM_008246.2_2 - 3e-10 39.4 20.6 1e-08 34.3 20.6 2.6 1 1 0 1 1 1 1 MFS_1 like family RELT PF12606.6 NM_177073.6_2 - 3.9e-18 64.4 0.4 9.1e-18 63.2 0.4 1.6 1 0 0 1 1 1 1 Tumour necrosis factor receptor superfamily member 19 TNFR_c6 PF00020.16 NM_177073.6_2 - 5.5e-06 26.6 2.2 5.5e-06 26.6 2.2 4.4 5 0 0 5 5 5 1 TNFR/NGFR cysteine-rich region BAH PF01426.16 NM_011842.3_1 - 5.2e-28 97.2 0.2 1.6e-27 95.7 0.2 1.9 1 1 0 1 1 1 1 BAH domain ELM2 PF01448.22 NM_011842.3_1 - 3.8e-16 59.5 0.1 1.1e-15 57.9 0.1 1.9 1 0 0 1 1 1 1 ELM2 domain GATA PF00320.25 NM_011842.3_1 - 1e-10 40.9 8.6 1e-10 40.9 8.6 1.9 2 0 0 2 2 2 1 GATA zinc finger Myb_DNA-binding PF00249.29 NM_011842.3_1 - 0.00023 21.1 0.0 0.00043 20.2 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Pkinase PF00069.23 NM_172928.5_2 - 1e-79 267.5 0.0 1.3e-79 267.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 NM_172928.5_2 - 3.8e-34 118.0 0.0 5.2e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DCX PF03607.15 NM_172928.5_2 - 4.1e-15 55.5 0.0 1.4e-14 53.7 0.0 2.0 2 0 0 2 2 2 1 Doublecortin Kdo PF06293.12 NM_172928.5_2 - 0.0013 18.0 0.1 0.0023 17.2 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 NM_172928.5_2 - 0.0035 16.6 0.0 0.0053 16.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.7 NM_172928.5_2 - 0.041 13.3 0.4 0.14 11.6 0.0 1.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL RIO1 PF01163.20 NM_172928.5_2 - 0.075 12.5 0.7 0.14 11.6 0.7 1.3 1 0 0 1 1 1 0 RIO1 family FAM76 PF16046.3 NM_199038.3_2 - 0.3 10.2 12.0 0.58 9.3 12.0 1.4 1 0 0 1 1 1 0 FAM76 protein IncA PF04156.12 NM_199038.3_2 - 1.3 8.6 22.4 1.6e+02 1.8 22.4 2.2 1 1 0 1 1 1 0 IncA protein Keratin_B2_2 PF13885.4 NM_001205009.1_1 - 1.1e-24 86.0 300.2 0.0001 22.1 51.9 6.7 1 1 4 5 5 5 4 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 NM_001205009.1_1 - 0.012 15.5 217.2 1.2 9.0 56.4 4.7 1 1 2 3 3 3 0 Keratin, high sulfur B2 protein MHC_I_2 PF14586.4 NM_001177775.1_1 - 2.3e-05 24.2 1.0 2.3e-05 24.2 1.0 2.1 1 1 1 2 2 2 1 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 ATP-synt_I PF03899.13 NM_001177775.1_1 - 0.038 14.2 0.9 0.076 13.2 0.9 1.4 1 0 0 1 1 1 0 ATP synthase I chain Tmemb_9 PF05434.9 NM_001177775.1_1 - 0.075 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 TMEM9 Thiolase_N PF00108.21 NM_130864.3_3 - 1.5e-85 286.6 0.5 2.3e-85 286.0 0.5 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 NM_130864.3_3 - 7.6e-51 170.8 0.3 1.5e-50 169.8 0.3 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.8 NM_130864.3_3 - 9.6e-05 22.4 0.0 0.00027 20.9 0.0 1.8 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.24 NM_130864.3_3 - 0.0045 16.5 0.4 0.042 13.3 0.1 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.8 NM_130864.3_3 - 0.0089 15.7 0.7 2.3 8.0 0.1 2.7 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Rsm22 PF09243.8 NM_001099917.1_1 - 0.05 12.7 1.6 0.064 12.4 1.6 1.1 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 MAP17 PF15807.3 NM_001099917.1_3 - 2e-47 160.4 0.4 2.5e-47 160.1 0.4 1.1 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 LYRIC PF15686.3 NM_001099917.1_3 - 0.00035 20.1 0.5 0.00048 19.7 0.5 1.1 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family DUF1510 PF07423.9 NM_001099917.1_3 - 0.001 18.4 0.3 0.0013 18.1 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) Zip PF02535.20 NM_001099917.1_3 - 0.02 14.0 0.0 0.022 13.9 0.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1772 PF08592.9 NM_001099917.1_3 - 0.034 14.3 0.0 0.053 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) MotB_plug PF13677.4 NM_001099917.1_3 - 0.086 12.3 0.0 0.086 12.3 0.0 1.9 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB Conotoxin PF02950.15 NM_001099917.1_3 - 0.11 13.3 0.5 8.7 7.3 0.2 2.6 2 1 0 2 2 2 0 Conotoxin Fer4_5 PF12801.5 NM_001099917.1_3 - 4.3 7.2 9.7 0.54 10.1 5.4 1.7 2 0 0 2 2 2 0 4Fe-4S binding domain Rep_fac-A_C PF08646.8 NM_026653.2_3 - 6.9e-57 191.2 8.1 1.4e-54 183.7 6.1 2.4 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.3 NM_026653.2_3 - 6.9e-35 118.8 1.1 1.6e-33 114.4 0.5 2.4 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.10 NM_026653.2_3 - 8.7e-32 109.0 0.4 1.4e-31 108.3 0.4 1.3 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.23 NM_026653.2_3 - 8.4e-11 41.6 0.0 3.1e-10 39.8 0.0 2.0 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain IBR PF01485.19 NM_026653.2_3 - 0.037 14.1 2.7 0.12 12.5 2.7 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain SUIM_assoc PF16619.3 NM_026653.2_3 - 0.15 12.1 4.4 0.32 11.0 4.4 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PX PF00787.22 NM_001127349.1_3 - 5.6e-24 84.2 1.9 8.6e-24 83.6 1.9 1.3 1 0 0 1 1 1 1 PX domain CATSPERG PF15064.4 NM_029714.3_1 - 0 1919.4 15.3 0 1919.1 15.3 1.0 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit gamma SRTM1 PF15872.3 NM_029714.3_1 - 0.06 13.4 1.7 0.15 12.1 1.7 1.6 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 DUF4501 PF14946.4 NM_177205.1_3 - 6.4e-89 296.6 0.0 9.2e-89 296.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4501) Tweety PF04906.11 NM_175274.5_1 - 4.5e-179 595.2 0.9 5.8e-179 594.8 0.9 1.1 1 0 0 1 1 1 1 Tweety Prominin PF05478.9 NM_175274.5_1 - 0.0025 15.7 0.1 0.0025 15.7 0.1 2.4 3 0 0 3 3 3 1 Prominin DUF4131 PF13567.4 NM_175274.5_1 - 0.07 12.6 4.2 0.18 11.3 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) FHA PF00498.24 NM_001168615.1_3 - 0.00044 20.4 0.0 0.00082 19.5 0.0 1.5 1 0 0 1 1 1 1 FHA domain Pribosyl_synth PF14572.4 NM_001164244.1_1 - 3.3e-101 336.8 1.4 4.6e-101 336.4 1.4 1.2 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.4 NM_001164244.1_1 - 4.2e-29 100.7 0.2 8.5e-29 99.7 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.25 NM_001164244.1_1 - 2.1e-06 27.2 0.2 5.8e-06 25.8 0.1 1.6 2 0 0 2 2 2 1 Phosphoribosyl transferase domain MHC_I PF00129.16 NM_010189.3_1 - 4e-57 192.5 0.0 5.3e-57 192.1 0.0 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 NM_010189.3_1 - 1.5e-10 41.3 0.0 2.9e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 NM_010189.3_1 - 0.00016 21.1 0.1 0.00022 20.6 0.1 1.2 1 0 0 1 1 1 1 MHC-I family domain Ig_3 PF13927.4 NM_010189.3_1 - 0.0013 19.1 0.1 0.0065 16.9 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Cytochrome_B PF00033.17 NM_010189.3_1 - 0.052 13.2 0.1 0.092 12.4 0.1 1.3 1 0 0 1 1 1 0 Cytochrome b/b6/petB MHC_II_beta PF00969.17 NM_010189.3_1 - 0.13 12.2 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Class II histocompatibility antigen, beta domain tRNA_U5-meth_tr PF05958.9 NM_001081000.2_3 - 5.6e-17 61.6 0.0 1.2e-16 60.5 0.0 1.5 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.4 NM_001081000.2_3 - 9.6e-11 41.6 0.0 1.6e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 NM_001081000.2_3 - 4.8e-10 39.9 0.1 1e-09 38.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 NM_001081000.2_3 - 7.8e-07 28.9 0.0 4.2e-06 26.5 0.0 1.9 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.10 NM_001081000.2_3 - 2.6e-06 27.8 0.1 1.4e-05 25.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.12 NM_001081000.2_3 - 2.9e-05 23.5 0.0 5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.15 NM_001081000.2_3 - 0.00032 20.1 0.0 0.00057 19.3 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Cons_hypoth95 PF03602.13 NM_001081000.2_3 - 0.00044 19.8 0.0 0.00076 19.0 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Ubie_methyltran PF01209.16 NM_001081000.2_3 - 0.00052 19.3 0.0 0.0008 18.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.4 NM_001081000.2_3 - 0.0006 19.6 0.0 0.0014 18.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.11 NM_001081000.2_3 - 0.0011 18.4 0.0 0.0017 17.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.4 NM_001081000.2_3 - 0.0013 18.6 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.8 NM_001081000.2_3 - 0.02 14.6 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase RRM_1 PF00076.20 NM_001081000.2_3 - 0.028 14.1 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CMAS PF02353.18 NM_001081000.2_3 - 0.032 13.4 0.0 0.05 12.8 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase NodS PF05401.9 NM_001081000.2_3 - 0.043 13.3 0.1 0.075 12.5 0.1 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) TPMT PF05724.9 NM_001081000.2_3 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) MetW PF07021.10 NM_001081000.2_3 - 0.11 11.9 0.1 0.19 11.2 0.1 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW N6_N4_Mtase PF01555.16 NM_001081000.2_3 - 0.12 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 DNA methylase Methyltransf_18 PF12847.5 NM_001081000.2_3 - 0.16 11.7 0.0 0.5 10.1 0.0 1.7 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_12 PF08242.10 NM_001081000.2_3 - 0.18 12.4 0.0 0.38 11.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain fn3 PF00041.19 NM_173182.2_3 - 1.8e-87 287.6 0.0 3.5e-10 40.0 0.0 10.0 10 1 0 10 10 10 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 NM_173182.2_3 - 2.2e-20 72.9 3.0 0.42 11.1 0.1 8.6 9 0 0 9 9 9 6 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 NM_173182.2_3 - 5.5e-10 39.5 0.0 2.6 8.5 0.0 6.2 6 0 0 6 6 6 3 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 NM_173182.2_3 - 2.4e-06 27.7 6.4 17 5.6 0.0 7.5 8 0 0 8 8 8 2 Interferon-alpha/beta receptor, fibronectin type III I-set PF07679.14 NM_173182.2_3 - 0.015 15.2 0.1 2.3 8.2 0.0 3.0 3 0 0 3 3 3 0 Immunoglobulin I-set domain PAX PF00292.16 NM_011037.4_1 - 1.5e-74 247.8 0.5 2.3e-74 247.2 0.5 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 NM_011037.4_1 - 1.8e-54 182.5 15.1 3.6e-54 181.6 15.1 1.5 1 0 0 1 1 1 1 Paired-box protein 2 C terminal HTH_32 PF13565.4 NM_011037.4_1 - 5.9e-05 23.5 0.1 0.055 14.0 0.0 3.6 2 1 1 3 3 3 2 Homeodomain-like domain HTH_23 PF13384.4 NM_011037.4_1 - 0.00034 20.2 0.0 0.00074 19.1 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Homeobox PF00046.27 NM_011037.4_1 - 0.025 14.2 0.1 0.055 13.2 0.1 1.5 1 0 0 1 1 1 0 Homeobox domain HTH_28 PF13518.4 NM_011037.4_1 - 0.049 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain PyrBI_leader PF08052.9 NM_011037.4_3 - 0.39 10.6 7.9 0.92 9.4 0.4 3.3 3 0 0 3 3 3 0 PyrBI operon leader peptide GRAM PF02893.18 NM_172611.4_1 - 1.6e-21 76.1 0.0 2.7e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 GRAM domain PRT_C PF08372.8 NM_172611.4_1 - 0.0015 18.2 1.2 0.0024 17.5 0.0 1.9 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal PDZ PF00595.22 NM_018884.2_1 - 3.1e-31 107.4 2.0 2.4e-16 59.7 0.3 2.4 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 NM_018884.2_1 - 1.2e-15 57.5 0.1 4.4e-07 30.0 0.0 3.0 3 0 0 3 3 3 2 PDZ domain zf-C3HC4_2 PF13923.4 NM_018884.2_1 - 6.9e-09 35.3 8.1 6.9e-09 35.3 8.1 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 NM_018884.2_1 - 3.3e-06 26.7 5.8 3.3e-06 26.7 5.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 NM_018884.2_1 - 3.4e-06 26.8 7.0 1.3e-05 25.0 7.0 2.1 1 0 0 1 1 1 1 RING-type zinc-finger Sina PF03145.14 NM_018884.2_1 - 4.3e-06 26.7 0.8 1.1e-05 25.4 0.8 1.6 1 0 0 1 1 1 1 Seven in absentia protein family zf-C3HC4_3 PF13920.4 NM_018884.2_1 - 1.2e-05 24.9 4.4 1.2e-05 24.9 4.4 2.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 NM_018884.2_1 - 1.5e-05 25.0 7.9 1.5e-05 25.0 7.9 2.3 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_4 PF15227.4 NM_018884.2_1 - 7.3e-05 22.7 6.9 0.00025 21.0 6.9 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.4 NM_018884.2_1 - 0.00017 21.2 6.0 0.00017 21.2 6.0 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 NM_018884.2_1 - 0.00019 21.2 5.5 0.00019 21.2 5.5 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-TRAF PF02176.16 NM_018884.2_1 - 0.00025 21.6 3.6 0.00025 21.6 3.6 3.4 2 1 1 3 3 3 1 TRAF-type zinc finger Tricorn_PDZ PF14685.4 NM_018884.2_1 - 0.023 14.5 0.1 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 Tricorn protease PDZ domain zf-rbx1 PF12678.5 NM_018884.2_1 - 0.27 11.4 8.2 0.17 12.1 5.3 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_6 PF14835.4 NM_018884.2_1 - 0.32 10.8 2.8 1 9.2 2.8 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-TRAF_2 PF15965.3 NM_018884.2_1 - 0.99 9.8 7.5 3.1 8.2 3.8 2.8 1 1 1 2 2 2 0 TRAF-like zinc-finger Rib_recp_KP_reg PF05104.10 NM_001293636.1_1 - 6e-05 24.0 29.9 6e-05 24.0 29.9 2.1 2 1 0 2 2 2 1 Ribosome receptor lysine/proline rich region DUF1510 PF07423.9 NM_001293636.1_1 - 0.011 15.1 4.5 0.028 13.7 4.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1510) Chromosome_seg PF13889.4 NM_001113283.1_1 - 6.6e-19 67.7 2.6 7e-19 67.6 0.3 2.3 2 0 0 2 2 2 1 Chromosome segregation during meiosis DUF4210 PF13915.4 NM_001113283.1_1 - 9.4e-14 51.6 0.0 2.6e-13 50.2 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) KA1 PF02149.17 NM_001113283.1_1 - 0.14 11.8 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Kinase associated domain 1 DUF1394 PF07159.10 NM_001146119.1_1 - 6.6e-146 485.2 1.8 8.2e-146 484.9 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Ras PF00071.20 NM_019491.5_1 - 8.9e-55 184.6 0.4 1.2e-54 184.2 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 NM_019491.5_1 - 2.6e-18 66.3 0.0 3.9e-18 65.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 NM_019491.5_1 - 2.5e-09 36.7 0.0 3.6e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 NM_019491.5_1 - 2e-07 30.9 0.1 0.00046 20.0 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 NM_019491.5_1 - 0.0012 18.3 0.1 0.0019 17.6 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 NM_019491.5_1 - 0.025 14.5 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.4 NM_019491.5_1 - 0.18 11.2 0.0 0.41 10.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain NumbF PF06311.10 NM_010950.2_1 - 7.9e-29 100.0 0.2 7.9e-29 100.0 0.2 2.7 3 0 0 3 3 3 1 NUMB domain PID PF00640.21 NM_010950.2_1 - 6.6e-28 97.4 0.1 6.6e-28 97.4 0.1 1.8 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 NM_010950.2_1 - 7.2e-07 29.3 0.0 1.3e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.4 NM_010950.2_1 - 2.3e-05 24.2 0.1 2.3e-05 24.2 0.1 1.8 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) DUF1932 PF09130.9 NM_010950.2_1 - 0.043 13.7 0.1 0.12 12.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1932) Interferon PF00143.17 NM_001161608.1_1 - 1.6e-26 93.3 0.0 2.2e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Interferon alpha/beta domain NAGLU_N PF12971.5 NM_001161608.1_1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain WAP PF00095.19 NM_001045554.1_3 - 5.6e-07 29.7 11.4 5.6e-07 29.7 11.4 2.3 3 0 0 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Myb_DNA-bind_5 PF13873.4 NM_001256142.1_1 - 1.8e-20 72.7 0.4 7.8e-20 70.6 0.1 2.1 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Hydrolase_4 PF12146.6 NM_026185.4_2 - 1.4e-05 24.3 0.0 2.3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 NIPSNAP PF07978.11 NM_028529.1_3 - 2.9e-50 168.6 0.4 5e-27 94.0 0.1 2.2 2 0 0 2 2 2 2 NIPSNAP Pkinase_Tyr PF07714.15 NM_145608.2_3 - 7e-63 212.2 0.0 9.4e-63 211.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_145608.2_3 - 1.1e-58 198.6 0.0 1.6e-58 198.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH3_9 PF14604.4 NM_145608.2_3 - 2.7e-13 49.4 0.1 5.2e-13 48.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_145608.2_3 - 6.2e-11 41.6 0.0 1.3e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_145608.2_3 - 8.6e-10 38.0 0.0 1.7e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain ABC1 PF03109.14 NM_145608.2_3 - 0.017 15.1 0.0 0.037 14.1 0.0 1.5 1 0 0 1 1 1 0 ABC1 family DUF3552 PF12072.6 NM_145608.2_3 - 0.097 11.9 10.5 0.16 11.2 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) OmpH PF03938.12 NM_145608.2_3 - 3.5 7.5 11.6 6 6.7 11.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Sema PF01403.17 NM_001308374.1_2 - 7.5e-86 288.4 0.0 1e-85 287.9 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 NM_001308374.1_2 - 2.8e-06 27.6 3.3 2.8e-06 27.6 3.3 3.1 3 0 0 3 3 3 1 Plexin repeat CcmD PF04995.12 NM_001308374.1_2 - 0.13 12.2 3.5 0.27 11.2 3.5 1.5 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Sema PF01403.17 NM_001308374.1_3 - 1.1e-24 86.8 0.0 1.5e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 Sema domain E1-E2_ATPase PF00122.18 NM_001164366.1_3 - 1.7e-37 128.8 0.0 1.7e-37 128.8 0.0 1.5 2 0 0 2 2 2 1 E1-E2 ATPase P5-ATPase PF12409.6 NM_001164366.1_3 - 5.8e-24 84.5 0.1 9.9e-24 83.7 0.1 1.4 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.24 NM_001164366.1_3 - 1e-18 68.3 0.0 8.7e-13 48.9 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.4 NM_001164366.1_3 - 0.0018 18.2 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 NM_001164366.1_3 - 0.0026 17.3 0.0 0.0057 16.2 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 NM_001164366.1_3 - 0.21 11.2 0.1 7.4 6.1 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase zf-H2C2_2 PF13465.4 NM_001289641.1_3 - 5.4e-93 301.5 91.7 1.2e-08 34.9 0.5 13.5 13 0 0 13 13 12 12 Zinc-finger double domain zf-C2H2 PF00096.24 NM_001289641.1_3 - 1.6e-68 223.4 101.2 1e-06 28.7 2.6 13.3 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_001289641.1_3 - 3.1e-33 111.4 114.1 0.001 19.5 2.5 14.0 13 0 0 13 13 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 NM_001289641.1_3 - 8e-24 83.0 76.5 0.0015 18.3 0.9 12.9 12 0 0 12 12 12 10 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 NM_001289641.1_3 - 7.7e-15 54.6 49.0 0.01 15.8 0.7 8.5 3 3 7 10 10 10 9 Zinc ribbon domain zf-C2H2_jaz PF12171.6 NM_001289641.1_3 - 2.3e-06 27.6 71.1 0.57 10.4 0.8 12.4 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 NM_001289641.1_3 - 4.5e-06 26.9 38.8 0.18 12.0 0.6 6.5 6 0 0 6 6 6 4 zinc-finger-containing domain CpXC PF14353.4 NM_001289641.1_3 - 6.9e-06 26.0 44.1 0.93 9.4 0.1 10.6 10 2 1 11 11 11 5 CpXC protein XPA_N PF01286.16 NM_001289641.1_3 - 0.00057 19.7 54.7 1.6 8.7 0.1 12.1 12 0 0 12 12 12 5 XPA protein N-terminal Csm1 PF12539.6 NM_001289641.1_3 - 0.0079 16.7 8.0 27 5.3 0.0 5.7 5 1 2 7 7 7 0 Chromosome segregation protein Csm1/Pcs1 zf-AN1 PF01428.14 NM_001289641.1_3 - 0.078 13.0 57.6 12 6.1 0.3 12.7 11 1 1 12 12 12 0 AN1-like Zinc finger zf-trcl PF13451.4 NM_001289641.1_3 - 0.086 12.6 42.8 8 6.3 0.1 11.5 11 1 1 12 12 12 0 Probable zinc-ribbon domain LRRNT PF01462.16 NM_001001999.1_3 - 1.1e-05 24.8 4.5 4.8e-05 22.8 1.5 3.0 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRRCT PF01463.22 NM_001001999.1_3 - 0.001 19.3 0.4 0.0051 17.1 0.4 2.3 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_8 PF13855.4 NM_001001999.1_3 - 0.019 14.6 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Leucine rich repeat Sugar_tr PF00083.22 NM_001164634.1_3 - 1.7e-30 106.1 16.3 2.6e-30 105.6 16.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 NM_001164634.1_3 - 5e-26 91.3 25.3 5e-26 91.3 25.3 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Staufen_C PF16482.3 NM_001291160.1_2 - 1.7e-49 166.5 0.0 1.7e-47 160.0 0.0 2.9 3 0 0 3 3 3 1 Staufen C-terminal domain dsrm PF00035.24 NM_001291160.1_2 - 5.6e-26 90.9 1.7 1e-11 45.2 0.0 3.0 3 0 0 3 3 3 2 Double-stranded RNA binding motif DND1_DSRM PF14709.5 NM_001291160.1_2 - 0.0053 16.9 0.0 0.32 11.1 0.0 2.9 2 0 0 2 2 2 1 double strand RNA binding domain from DEAD END PROTEIN 1 LPP20 PF02169.14 NM_001291160.1_2 - 0.085 13.1 0.1 1 9.6 0.0 2.2 2 0 0 2 2 2 0 LPP20 lipoprotein ATG16 PF08614.9 NM_001111111.1_2 - 4.6e-35 121.5 27.0 4.6e-35 121.5 27.0 2.1 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) WD40 PF00400.30 NM_001111111.1_2 - 1.3e-25 89.0 17.0 2.2e-06 28.1 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_001111111.1_2 - 2.4e-06 27.6 0.7 1.5 9.0 0.0 4.7 2 1 3 5 5 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 NM_001111111.1_2 - 0.0049 16.6 0.0 3.2 7.4 0.0 3.4 4 0 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 NM_001111111.1_2 - 0.011 14.3 0.7 6.4 5.1 0.0 3.4 1 1 2 3 3 3 0 Nucleoporin Nup120/160 IFT57 PF10498.7 NM_001111111.1_2 - 0.037 12.9 12.0 0.058 12.2 12.0 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Atg14 PF10186.7 NM_001111111.1_2 - 0.29 10.0 17.4 0.023 13.6 12.0 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 P4Ha_N PF08336.9 NM_001111111.1_2 - 0.61 10.0 12.4 0.18 11.7 9.2 1.7 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Phage_GP20 PF06810.9 NM_001111111.1_2 - 2.7 7.7 10.0 2.6 7.7 8.3 1.8 1 1 0 1 1 1 0 Phage minor structural protein GP20 GBP_C PF02841.12 NM_001111111.1_2 - 7 5.8 20.7 12 5.1 20.7 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain IncA PF04156.12 NM_001111111.1_2 - 7.6 6.1 22.5 16 5.0 22.5 1.6 1 0 0 1 1 1 0 IncA protein Cofilin_ADF PF00241.18 NM_001177371.1_3 - 2.8e-17 62.9 0.0 4.8e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein PNISR PF15996.3 NM_001177371.1_3 - 0.46 10.5 32.0 0.014 15.5 25.4 1.8 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR CC2-LZ PF16516.3 NM_001271456.1_3 - 4.6e-07 30.0 21.8 4.6e-07 30.0 21.8 5.3 3 2 2 5 5 5 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FlxA PF14282.4 NM_001271456.1_3 - 0.0064 16.3 15.3 0.0064 16.3 15.3 4.2 3 1 0 4 4 4 1 FlxA-like protein NPV_P10 PF05531.10 NM_001271456.1_3 - 1.7 9.1 15.8 8.7 6.8 0.4 4.3 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein G-gamma PF00631.20 NM_001285908.1_1 - 1.1e-17 63.6 0.0 1.9e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 GGL domain Fibrillarin PF01269.15 NM_007991.3_2 - 9.4e-109 361.7 0.0 1.2e-108 361.4 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.8 NM_007991.3_2 - 0.00022 20.9 0.0 0.00032 20.3 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.17 NM_007991.3_2 - 0.0025 17.5 0.0 0.004 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.17 NM_007991.3_2 - 0.025 14.6 0.1 0.063 13.3 0.1 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.15 NM_007991.3_2 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F An_peroxidase PF03098.13 NM_007946.2_3 - 9.1e-182 605.2 0.0 1.1e-181 604.9 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase zf-DHHC PF01529.18 NM_178395.3_1 - 9.4e-36 122.7 12.1 9.4e-36 122.7 12.1 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Alpha_GJ PF03229.11 NM_178395.3_1 - 0.39 11.1 9.6 0.62 10.5 9.6 1.3 1 0 0 1 1 1 0 Alphavirus glycoprotein J KRAB PF01352.25 NM_022981.4_2 - 2.2e-39 132.7 5.1 6.3e-20 70.4 0.1 2.6 2 0 0 2 2 2 2 KRAB box SCAN PF02023.15 NM_022981.4_2 - 5.9e-37 125.2 3.0 1.2e-36 124.2 3.0 1.6 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 NM_022981.4_2 - 1.2e-30 104.4 29.5 8.9e-09 35.3 1.4 6.6 5 1 1 6 6 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 NM_022981.4_2 - 9.4e-21 72.9 36.8 0.0002 21.5 5.5 6.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 NM_022981.4_2 - 1.8e-13 49.9 33.7 0.00089 19.8 0.3 6.4 5 0 0 5 5 5 5 C2H2-type zinc finger XPA_N PF01286.16 NM_022981.4_2 - 0.00049 19.9 13.6 9.2 6.3 0.0 5.5 5 0 0 5 5 5 0 XPA protein N-terminal zf-C2H2_jaz PF12171.6 NM_022981.4_2 - 0.0015 18.6 19.0 0.043 14.0 0.0 6.3 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 NM_022981.4_2 - 0.0021 18.6 14.2 0.16 12.6 0.5 3.6 1 1 2 3 3 3 3 zinc-ribbon family Zn-ribbon_8 PF09723.8 NM_022981.4_2 - 0.0025 17.8 15.5 0.83 9.7 4.4 4.5 2 2 2 4 4 4 3 Zinc ribbon domain zf-UBP PF02148.17 NM_022981.4_2 - 0.012 15.8 14.5 4.5 7.6 2.9 4.1 2 1 1 3 3 2 0 Zn-finger in ubiquitin-hydrolases and other protein HypA PF01155.17 NM_022981.4_2 - 0.077 12.9 10.2 0.79 9.6 1.9 3.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYDLN_acid PF09538.8 NM_022981.4_2 - 0.26 11.8 3.3 29 5.3 0.0 4.3 1 1 1 3 3 3 0 Protein of unknown function (FYDLN_acid) zf-C2H2_6 PF13912.4 NM_022981.4_2 - 0.28 11.1 26.8 0.22 11.4 0.2 5.6 5 0 0 5 5 5 0 C2H2-type zinc finger ADK_lid PF05191.12 NM_022981.4_2 - 0.89 9.5 7.0 3.9 7.4 0.9 3.5 2 1 1 3 3 3 0 Adenylate kinase, active site lid LIM PF00412.20 NM_022981.4_2 - 1.1 9.4 13.7 11 6.3 0.8 4.1 1 1 0 3 3 3 0 LIM domain zf-LYAR PF08790.9 NM_022981.4_2 - 1.5 8.6 14.0 4 7.3 0.2 5.3 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger zf-C2HE PF16278.3 NM_022981.4_2 - 8.2 6.8 16.1 10 6.5 0.2 5.1 1 1 3 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3268 PF11672.6 NM_022981.4_2 - 9.1 6.5 10.8 19 5.5 1.3 3.1 2 1 1 3 3 3 0 zinc-finger-containing domain Hormone_1 PF00103.18 NM_023741.2_3 - 1e-53 182.2 1.5 1.2e-53 181.9 1.5 1.0 1 0 0 1 1 1 1 Somatotropin hormone family DSPc PF00782.18 NM_001289554.1_1 - 1.9e-20 72.9 0.2 3e-20 72.3 0.2 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.18 NM_001289554.1_1 - 0.00029 21.2 0.1 0.0011 19.4 0.1 1.9 1 1 0 1 1 1 1 Rhodanese-like domain Init_tRNA_PT PF04179.10 NM_001289554.1_1 - 0.0094 16.1 0.0 0.024 14.8 0.0 1.6 1 0 0 1 1 1 1 Rit1 DUSP-like domain Takusan PF04822.11 NM_001242945.1_1 - 2.6e-19 68.7 9.5 2.6e-19 68.7 9.5 1.6 2 0 0 2 2 2 1 Takusan DUF2551 PF10826.6 NM_001242945.1_1 - 0.085 13.0 0.8 0.14 12.2 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2551) NTP_transf_2 PF01909.21 NM_001169131.1_1 - 3e-17 62.6 0.0 5.8e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.17 NM_001169131.1_1 - 1.5e-15 57.0 0.0 2.8e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase PH PF00169.27 NM_001291336.1_3 - 3.3e-05 24.2 0.0 5.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 NM_001291336.1_3 - 0.00032 21.0 0.0 0.00052 20.3 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain LRR_8 PF13855.4 NM_173415.4_1 - 1.2e-62 207.3 38.2 2.1e-14 52.9 2.5 5.0 2 1 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.5 NM_173415.4_1 - 7.1e-17 61.1 5.9 0.00079 19.6 0.1 5.6 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 NM_173415.4_1 - 2.5e-07 30.2 0.5 0.24 10.8 0.0 4.0 1 1 2 4 4 4 4 Leucine-rich repeat LRRNT PF01462.16 NM_173415.4_1 - 7.4e-06 25.3 4.7 2.1e-05 23.9 4.7 1.8 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 NM_173415.4_1 - 0.002 18.2 8.4 3.7 8.2 0.2 6.6 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_6 PF13516.4 NM_173415.4_1 - 9.8 6.4 12.4 12 6.1 0.0 4.6 6 0 0 6 6 6 0 Leucine Rich repeat ATG13 PF10033.7 NM_145528.3_3 - 6.8e-14 51.9 0.0 2e-07 30.8 0.1 2.6 1 1 1 2 2 2 2 Autophagy-related protein 13 PI3Ka PF00613.18 NM_020272.2_1 - 2.9e-64 215.8 0.9 5.4e-64 214.9 0.9 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.25 NM_020272.2_1 - 5.4e-58 196.6 0.3 1.2e-57 195.5 0.3 1.6 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_rbd PF00794.16 NM_020272.2_1 - 5.5e-29 100.3 1.6 7.7e-29 99.9 0.0 2.1 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.22 NM_020272.2_1 - 2.9e-15 56.4 0.0 6e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.4 NM_020272.2_1 - 0.0025 17.1 0.0 0.01 15.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4135) DUF3244 PF11589.6 NM_020272.2_1 - 0.11 12.4 0.4 2.4 8.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3244) Pkinase_Tyr PF07714.15 NM_022012.3_2 - 8.7e-63 211.9 0.0 1.3e-62 211.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_022012.3_2 - 1.8e-58 197.9 0.0 1.8e-58 197.9 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain SH3_9 PF14604.4 NM_022012.3_2 - 2.3e-14 52.8 0.1 4.6e-14 51.9 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 NM_022012.3_2 - 4.8e-12 45.1 0.1 8.3e-12 44.4 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 NM_022012.3_2 - 1.5e-11 43.6 0.0 4.3e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain RRM_1 PF00076.20 NM_001277123.1_1 - 2.1e-41 139.4 0.5 7.7e-15 54.3 0.3 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 NM_001277123.1_1 - 8.9e-08 32.0 0.0 0.14 12.1 0.0 3.6 2 1 1 3 3 3 2 RNA recognition motif RRM_5 PF13893.4 NM_001277123.1_1 - 0.0001 21.8 0.0 0.00022 20.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_001277123.1_1 - 0.039 13.7 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif Folate_rec PF03024.12 NM_001303231.1_3 - 1.1e-60 204.3 24.8 1.4e-60 204.0 24.8 1.1 1 0 0 1 1 1 1 Folate receptor family LRR_4 PF12799.5 NM_026431.2_2 - 7e-11 42.0 1.6 0.0004 20.6 0.0 3.3 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 NM_026431.2_2 - 8.4e-06 25.3 0.7 0.0061 16.2 0.1 2.9 1 1 1 2 2 2 2 Leucine rich repeat LRR_9 PF14580.4 NM_026431.2_2 - 2.5e-05 23.7 0.2 0.00011 21.6 0.2 1.8 1 1 1 2 2 2 1 Leucine-rich repeat 7tm_1 PF00001.19 NM_194057.2_1 - 1.3e-17 63.7 0.0 2.7e-17 62.7 0.0 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cytochrome_B PF00033.17 NM_194057.2_1 - 0.013 15.2 0.2 0.029 14.1 0.1 1.7 1 1 1 2 2 2 0 Cytochrome b/b6/petB F-box PF00646.31 NM_025785.2_3 - 0.0029 17.3 0.1 0.0084 15.8 0.1 1.9 2 0 0 2 2 2 1 F-box domain Elongin_A PF06881.9 NM_025785.2_3 - 0.0029 17.9 0.1 0.0029 17.9 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Cadherin PF00028.15 NM_198656.2_1 - 6.3e-52 173.9 0.0 2.1e-14 53.6 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_3 PF16184.3 NM_198656.2_1 - 2.1e-09 37.3 0.7 0.031 14.2 0.0 4.5 4 0 0 4 4 4 3 Cadherin-like 7tm_4 PF13853.4 NM_147076.2_2 - 7.7e-105 350.5 27.9 1e-104 350.1 27.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 NM_147076.2_2 - 2.9e-19 69.2 24.8 6e-19 68.2 24.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 NM_147076.2_2 - 5.6e-09 35.6 26.4 6.2e-09 35.5 25.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4561 PF15120.4 NM_147076.2_2 - 0.14 11.8 0.2 0.23 11.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4561) RRM_1 PF00076.20 NM_001114079.2_3 - 5.4e-90 295.1 2.5 1e-23 82.7 0.1 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.16 NM_001114079.2_3 - 1.9e-23 82.3 1.8 2.2e-23 82.1 0.5 1.9 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.4 NM_001114079.2_3 - 2.1e-17 62.8 1.4 2.7e-06 26.9 0.2 4.2 1 1 2 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 NM_001114079.2_3 - 6.8e-07 28.9 0.0 0.31 10.8 0.0 3.7 4 0 0 4 4 4 2 Occluded RNA-recognition motif SET_assoc PF11767.6 NM_001114079.2_3 - 7.9e-07 28.5 0.4 0.37 10.3 0.0 4.3 4 0 0 4 4 4 2 Histone lysine methyltransferase SET associated Nup35_RRM_2 PF14605.4 NM_001114079.2_3 - 4.6e-06 26.4 0.3 0.57 10.1 0.0 4.3 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.6 NM_001114079.2_3 - 7.7e-06 25.8 2.2 0.19 11.7 0.3 4.3 4 0 0 4 4 4 1 Limkain b1 RRM_7 PF16367.3 NM_001114079.2_3 - 1.1e-05 25.3 0.7 7.3 6.7 0.0 4.7 4 2 0 4 4 4 2 RNA recognition motif RRM_3 PF08777.9 NM_001114079.2_3 - 2e-05 24.4 3.4 0.79 9.7 0.9 3.9 4 0 0 4 4 4 3 RNA binding motif OB_RNB PF08206.9 NM_001114079.2_3 - 0.042 13.4 2.9 26 4.5 0.1 3.4 3 0 0 3 3 3 0 Ribonuclease B OB domain Cas_Cas2CT1978 PF09707.8 NM_001114079.2_3 - 0.11 12.4 0.1 4.6 7.2 0.0 3.1 4 0 0 4 4 4 0 CRISPR-associated protein (Cas_Cas2CT1978) Sod_Cu PF00080.18 NM_016892.3_1 - 1.9e-39 134.9 0.2 2.7e-39 134.4 0.2 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) HMA PF00403.24 NM_016892.3_1 - 4e-10 39.9 0.2 6.4e-10 39.2 0.2 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain Guanylate_cyc PF00211.18 NM_001159536.1_2 - 2.5e-127 421.5 0.1 8.6e-66 220.9 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.3 NM_001159536.1_2 - 1.6e-31 109.8 6.6 1.6e-31 109.8 6.6 1.9 3 0 0 3 3 3 1 Adenylyl cyclase N-terminal extracellular and transmembrane region HNOBA PF07701.12 NM_001159536.1_2 - 0.0063 15.9 1.2 0.49 9.7 0.7 2.4 2 0 0 2 2 2 2 Heme NO binding associated Peptidase_S49_N PF08496.8 NM_001159536.1_2 - 0.14 12.1 3.9 0.12 12.3 1.8 2.0 1 1 1 2 2 2 0 Peptidase family S49 N-terminal fn3_4 PF16794.3 NM_001159536.1_2 - 0.15 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Fibronectin-III type domain C2 PF00168.28 NM_001100395.1_3 - 2.1e-77 255.9 7.8 3.1e-17 62.6 0.0 9.3 7 2 0 8 8 8 7 C2 domain FerB PF08150.10 NM_001100395.1_3 - 2.2e-31 108.1 0.2 9e-31 106.2 0.0 2.2 2 0 0 2 2 2 1 FerB (NUC096) domain Ferlin_C PF16165.3 NM_001100395.1_3 - 7.3e-31 107.1 2.4 1.9e-27 96.0 0.1 4.0 2 2 2 4 4 4 2 Ferlin C-terminus FerI PF08151.10 NM_001100395.1_3 - 3.5e-20 71.7 1.1 3.5e-20 71.7 1.1 2.0 2 0 0 2 2 2 1 FerI (NUC094) domain DUF4674 PF15719.3 NM_001100395.1_3 - 0.18 11.6 3.4 0.43 10.4 3.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) DUF1018 PF06252.10 NM_001100395.1_3 - 1.6 9.7 5.6 1.4 9.8 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1018) Gly_acyl_tr_N PF06021.9 NM_001145060.1_1 - 2e-78 263.0 0.0 3.2e-78 262.3 0.0 1.3 1 1 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.8 NM_001145060.1_1 - 2.3e-11 43.6 0.0 4.3e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region FR47 PF08445.8 NM_001145060.1_1 - 7.2e-07 29.0 0.0 1.2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.23 NM_001145060.1_1 - 0.0045 17.1 0.0 0.0077 16.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family TPR_1 PF00515.26 NM_177368.4_2 - 6.1e-35 117.5 30.4 1.4e-06 27.7 0.2 9.7 8 1 1 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.15 NM_177368.4_2 - 1.3e-33 112.3 25.8 3.2e-07 29.8 0.2 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat DUF1736 PF08409.9 NM_177368.4_2 - 3.3e-30 103.8 1.5 1.3e-29 101.8 1.5 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_8 PF13181.4 NM_177368.4_2 - 9.7e-30 100.1 24.4 7.2e-05 22.6 0.3 9.6 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_12 PF13424.4 NM_177368.4_2 - 5.5e-23 80.9 25.6 2.9e-09 37.0 0.0 6.0 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.4 NM_177368.4_2 - 1.4e-22 79.9 17.0 6.6e-05 23.4 0.0 6.1 3 2 2 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.4 NM_177368.4_2 - 9e-19 66.8 20.8 4.4e-05 22.9 0.2 7.4 3 3 4 7 7 7 5 TPR repeat TPR_17 PF13431.4 NM_177368.4_2 - 1.3e-14 53.3 21.9 0.033 14.4 0.8 9.8 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_10 PF13374.4 NM_177368.4_2 - 7.2e-13 47.8 35.4 1.5e-05 24.6 0.1 8.6 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_7 PF13176.4 NM_177368.4_2 - 1.3e-12 46.6 18.3 2.5e-05 23.9 0.1 8.3 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.4 NM_177368.4_2 - 1.6e-10 41.2 14.2 0.038 14.4 0.0 5.1 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.4 NM_177368.4_2 - 1.2e-09 38.0 15.5 0.2 12.5 0.1 8.2 5 3 4 9 9 8 2 Tetratricopeptide repeat TPR_4 PF07721.12 NM_177368.4_2 - 4.3e-08 32.9 0.1 0.018 15.5 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_9 PF13371.4 NM_177368.4_2 - 1.5e-07 31.3 4.6 0.018 15.1 2.3 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.4 NM_177368.4_2 - 2.8e-07 30.6 4.4 0.0047 17.3 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat NARP1 PF12569.6 NM_177368.4_2 - 2.3e-06 26.7 2.5 0.063 12.0 0.4 3.2 2 1 1 3 3 3 3 NMDA receptor-regulated protein 1 ANAPC3 PF12895.5 NM_177368.4_2 - 1.8e-05 24.7 15.1 0.038 14.1 1.0 4.6 2 1 4 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.10 NM_177368.4_2 - 2.3e-05 24.2 8.4 0.27 11.2 0.1 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat PMT_2 PF13231.4 NM_177368.4_2 - 0.00011 22.3 6.1 0.00011 22.3 6.1 3.1 4 0 0 4 4 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase TPR_21 PF09976.7 NM_177368.4_2 - 0.0069 16.0 2.1 3.2 7.4 0.0 4.0 2 1 2 4 4 4 1 Tetratricopeptide repeat-like domain TPR_15 PF13429.4 NM_177368.4_2 - 0.0089 15.1 9.6 0.067 12.3 0.3 4.0 1 1 2 4 4 4 1 Tetratricopeptide repeat RPN7 PF10602.7 NM_177368.4_2 - 0.076 12.5 0.9 0.46 10.0 0.1 2.7 2 1 1 3 3 3 0 26S proteasome subunit RPN7 Coatomer_E PF04733.12 NM_177368.4_2 - 0.11 11.8 0.8 2.4 7.3 0.0 2.8 3 0 0 3 3 3 0 Coatomer epsilon subunit SNAP PF14938.4 NM_177368.4_2 - 0.22 10.8 4.3 6.6 5.9 0.4 2.9 2 1 1 3 3 3 0 Soluble NSF attachment protein, SNAP PPR PF01535.18 NM_177368.4_2 - 1 9.6 3.6 40 4.6 0.0 3.5 4 0 0 4 4 2 0 PPR repeat MIT PF04212.16 NM_177368.4_2 - 1.4 9.0 10.5 2.4 8.2 0.0 4.1 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain Mtf2_C PF14061.4 NM_013827.3_3 - 9e-27 92.9 0.1 1.7e-26 92.0 0.1 1.5 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 PHD PF00628.27 NM_013827.3_3 - 1.1e-15 57.1 28.6 1.4e-11 44.0 8.8 2.7 2 0 0 2 2 2 2 PHD-finger Prok-RING_1 PF14446.4 NM_013827.3_3 - 0.00078 19.2 4.1 0.00078 19.2 4.1 3.2 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 DUF4537 PF15057.4 NM_013827.3_3 - 0.0042 16.9 0.0 0.019 14.8 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4537) DUF1325 PF07039.9 NM_013827.3_3 - 0.03 14.3 0.0 0.5 10.3 0.0 2.3 2 0 0 2 2 2 0 SGF29 tudor-like domain C1_1 PF00130.20 NM_013827.3_3 - 3.5 7.5 21.6 0.048 13.4 1.4 3.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) WD40 PF00400.30 NM_013625.4_1 - 1.1e-58 193.7 16.4 6e-08 33.1 0.3 8.8 8 1 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 NM_013625.4_1 - 6.2e-12 45.5 3.9 0.12 12.5 0.1 5.6 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 NM_013625.4_1 - 4.9e-09 35.2 9.9 0.043 12.3 0.0 5.5 2 2 5 7 7 7 4 Nucleoporin Nup120/160 LisH PF08513.9 NM_013625.4_1 - 4.6e-08 32.6 0.4 9.1e-08 31.7 0.4 1.5 1 0 0 1 1 1 1 LisH Pox_A_type_inc PF04508.10 NM_013625.4_1 - 0.008 15.9 0.1 0.019 14.7 0.1 1.6 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat Nucleoporin_N PF08801.9 NM_013625.4_1 - 0.029 13.0 1.4 2.5 6.6 0.0 3.4 2 1 2 4 4 4 0 Nup133 N terminal like LisH_2 PF16045.3 NM_013625.4_1 - 0.074 12.0 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 LisH Guanylate_cyc PF00211.18 NM_145067.3_2 - 2.1e-65 219.7 0.0 3.2e-65 219.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.15 NM_145067.3_2 - 7.2e-31 107.3 0.0 1.6e-30 106.1 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 NM_145067.3_2 - 1.6e-24 86.6 0.1 2.9e-24 85.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain ANF_receptor PF01094.26 NM_145067.3_2 - 2.6e-07 29.9 0.0 5.4e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Receptor family ligand binding region DUF1049 PF06305.9 NM_145067.3_2 - 0.38 10.5 5.8 0.71 9.6 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) GST_N PF02798.18 NM_010360.2_2 - 1.9e-21 76.0 0.0 4.4e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 NM_010360.2_2 - 8.1e-18 64.3 0.3 2e-17 63.1 0.1 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 NM_010360.2_2 - 3.1e-17 62.5 0.4 1.1e-16 60.7 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 NM_010360.2_2 - 0.049 13.9 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 NM_010360.2_2 - 0.11 12.4 0.7 0.33 10.8 0.2 2.1 3 1 0 3 3 3 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 NM_010360.2_2 - 0.58 9.9 3.5 0.88 9.3 1.0 2.5 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF2181 PF10223.7 NM_001163627.1_2 - 3.2e-98 327.9 0.2 4.1e-98 327.5 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) Xlink PF00193.15 NM_001177786.1_2 - 8.5e-19 67.6 0.0 1.7e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 Extracellular link domain UbiA PF01040.16 NM_027873.2_2 - 2.7e-40 138.1 10.5 4.1e-40 137.6 10.5 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Peptidase_C1 PF00112.21 NM_023476.3_2 - 5.3e-52 177.0 0.0 7.1e-52 176.5 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Pacifastin_I PF05375.11 NM_023476.3_2 - 3.7e-05 23.2 3.6 0.00013 21.5 3.6 1.9 1 0 0 1 1 1 1 Pacifastin inhibitor (LCMII) Somatomedin_B PF01033.15 NM_023476.3_2 - 0.0047 17.2 15.3 0.0047 17.2 15.3 2.7 2 1 1 3 3 3 1 Somatomedin B domain Propeptide_C1 PF08127.11 NM_023476.3_2 - 0.02 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C1 propeptide CwfJ_C_1 PF04677.13 NM_001081077.1_2 - 7.9e-34 116.0 0.0 1.6e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.12 NM_001081077.1_2 - 2.2e-16 60.4 0.1 3.9e-16 59.6 0.1 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Metallophos_3 PF14582.4 NM_001081077.1_2 - 0.011 15.0 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily V1R PF03402.12 NM_030737.2_2 - 3.2e-17 62.9 6.6 3.2e-17 62.9 6.6 1.5 2 0 0 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 NM_030737.2_2 - 5.9e-12 45.2 9.8 8.4e-12 44.7 9.8 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 NM_030737.2_2 - 2e-05 23.9 11.5 3e-05 23.3 11.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Mob1_phocein PF03637.15 NM_178061.5_1 - 1.3e-77 259.5 0.3 1.8e-77 259.0 0.3 1.2 1 0 0 1 1 1 1 Mob1/phocein family Vpu PF00558.17 NM_007587.2_1 - 0.14 11.8 0.8 0.25 11.0 0.8 1.4 1 0 0 1 1 1 0 Vpu protein DUF4366 PF14283.4 NM_007587.2_1 - 0.17 11.2 1.7 0.23 10.8 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) OAD_gamma PF04277.11 NM_007587.2_1 - 0.22 12.0 4.9 0.38 11.3 4.9 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Calc_CGRP_IAPP PF00214.17 NM_007587.2_3 - 1.1e-30 106.3 0.0 1.7e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family RNase_T PF00929.22 NM_001291221.1_1 - 3.5e-16 60.1 0.0 4.6e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.18 NM_001291221.1_1 - 0.021 14.4 0.2 0.16 11.5 0.2 2.4 1 1 0 1 1 1 0 3'-5' exonuclease WD40 PF00400.30 NM_021312.5_1 - 3.4e-30 103.5 37.1 4.5e-05 24.0 0.6 8.4 8 0 0 8 8 8 7 WD domain, G-beta repeat NLE PF08154.10 NM_021312.5_1 - 8e-17 61.4 0.1 1.5e-16 60.5 0.1 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain DUF676 PF05057.12 NM_026604.4_2 - 9e-62 208.3 0.0 1.5e-61 207.6 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3657 PF12394.6 NM_026604.4_2 - 7.6e-17 61.5 0.7 4.3e-16 59.1 0.7 2.5 1 0 0 1 1 1 1 Protein FAM135 PGAP1 PF07819.11 NM_026604.4_2 - 6.6e-05 22.6 0.0 0.00016 21.3 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.13 NM_026604.4_2 - 0.0033 16.5 0.1 0.006 15.7 0.1 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase GvpD PF07088.9 NM_026604.4_2 - 0.067 11.7 0.0 0.11 11.0 0.0 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein UQ_con PF00179.24 NM_009454.2_1 - 6.1e-46 155.4 0.0 9e-46 154.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 NM_009454.2_1 - 0.043 13.4 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.20 NM_009454.2_1 - 0.058 13.6 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 RWD domain # # Program: hmmscan # Version: 3.1b2 (February 2015) # Pipeline mode: SCAN # Query file: /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/refseq_mouse/wd/refseq_mouse_5000.p.fa # Target file: /home/yduan/database/Pfam/Pfam-A.hmm # Option settings: hmmscan -o /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/refseq_mouse/hmmscan.outm --tblout /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/refseq_mouse/hmmscan.t.out /home/yduan/database/Pfam/Pfam-A.hmm /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/random5k/refseq_mouse/wd/refseq_mouse_5000.p.fa # Current dir: /home/yduan/work_file/lncRNAdb/methods_assement # Date: Sat Jun 30 11:17:12 2018 # [ok]